locus-tag	class	description
EXW53_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW53_00010	COG0592	DNA-directed DNA polymerase activity
EXW53_00015	COG2501	S4 domain
EXW53_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW53_00025	COG0187	DNA topoisomerase II activity
EXW53_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW53_00065	COG0516	GMP reductase activity
EXW53_00065	COG0517	IMP dehydrogenase activity
EXW53_00070	COG1686	Belongs to the peptidase S11 family
EXW53_00100	COG1428	Deoxynucleoside kinase
EXW53_00105	COG1428	Deoxynucleoside kinase
EXW53_00110	COG1335	isochorismatase
EXW53_00115	COG0590	tRNA wobble adenosine to inosine editing
EXW53_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW53_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW53_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW53_00180	COG1982	Orn Lys Arg decarboxylase major
EXW53_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW53_00190	COG0470	DNA polymerase III
EXW53_00195	COG1774	PSP1 C-terminal conserved region
EXW53_00200	COG4467	Involved in initiation control of chromosome replication
EXW53_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW53_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW53_00220	COG2002	toxin-antitoxin pair type II binding
EXW53_00230	COG0084	hydrolase, TatD family'
EXW53_00240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW53_00250	COG4466	Protein conserved in bacteria
EXW53_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW53_00270	COG0251	oxidation-reduction process
EXW53_00275	COG2088	sporulation resulting in formation of a cellular spore
EXW53_00280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW53_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW53_00305	COG2002	toxin-antitoxin pair type II binding
EXW53_00310	COG2244	polysaccharide biosynthetic process
EXW53_00315	COG3956	TIGRFAM MazG family protein
EXW53_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW53_00340	COG1098	S1 RNA binding domain
EXW53_00355	COG2208	phosphoserine phosphatase activity
EXW53_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW53_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW53_00375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW53_00380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW53_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW53_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW53_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW53_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW53_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW53_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW53_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW53_00420	COG1396	sequence-specific DNA binding
EXW53_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW53_00430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW53_00515	COG3880	PFAM UvrB UvrC protein
EXW53_00520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW53_00525	COG0542	response to heat
EXW53_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW53_00535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW53_00540	COG4956	integral membrane protein (PIN domain superfamily)
EXW53_00545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW53_00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW53_00560	COG1045	serine acetyltransferase
EXW53_00565	COG0215	cysteine-tRNA ligase activity
EXW53_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW53_00580	COG3688	RNA-binding protein containing a PIN domain
EXW53_00590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW53_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW53_00600	COG0250	Participates in transcription elongation, termination and antitermination
EXW53_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW53_00610	COG0081	regulation of translation
EXW53_00615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW53_00620	COG0222	ribosome binding
EXW53_00625	COG2813	Specifically methylates the guanine in position
EXW53_00630	COG0085	RNA polymerase activity
EXW53_00635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW53_00640	COG1358	cellular component organization or biogenesis
EXW53_00645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW53_00655	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW53_00660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW53_00665	COG0051	transcription antitermination factor activity, RNA binding
EXW53_00670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW53_00675	COG0088	Forms part of the polypeptide exit tunnel
EXW53_00680	COG0089	rRNA binding
EXW53_00685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW53_00695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW53_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW53_00725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW53_00730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW53_00740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW53_00750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW53_00760	COG1841	ribosomal large subunit assembly
EXW53_00765	COG0200	Binds to the 23S rRNA
EXW53_00770	COG0201	protein transport
EXW53_00775	COG0563	adenylate kinase activity
EXW53_00780	COG0024	Methionine aminopeptidase
EXW53_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW53_00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW53_00800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW53_00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW53_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW53_00855	COG0489	protein tyrosine kinase activity
EXW53_00865	COG2194	sulfuric ester hydrolase activity
EXW53_00870	COG0726	polysaccharide deacetylase
EXW53_00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW53_00955	COG4856	YbbR-like protein
EXW53_00995	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_01000	COG2011	ABC-type metal ion transport system permease component
EXW53_01010	COG1464	Belongs to the NlpA lipoprotein family
EXW53_01020	COG0277	FAD linked oxidase domain protein
EXW53_01025	COG2271	Major facilitator Superfamily
EXW53_01035	COG2814	Major facilitator Superfamily
EXW53_01055	COG0601	transmembrane transport
EXW53_01060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW53_01065	COG0444	Belongs to the ABC transporter superfamily
EXW53_01070	COG4608	Belongs to the ABC transporter superfamily
EXW53_01075	COG4166	transmembrane transport
EXW53_01085	COG2207	Transcriptional regulator
EXW53_01100	COG4166	transmembrane transport
EXW53_01105	COG4166	transmembrane transport
EXW53_01110	COG0656	L-ascorbic acid biosynthetic process
EXW53_01115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW53_01125	COG4149	molybdate abc transporter
EXW53_01130	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW53_01135	COG1910	domain protein
EXW53_01150	COG0697	spore germination
EXW53_01165	COG0204	Acyl-transferase
EXW53_01175	COG1609	Transcriptional regulator
EXW53_01185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_01205	COG5298	Protein conserved in bacteria
EXW53_01230	COG0488	(ABC) transporter
EXW53_01235	COG4585	Histidine kinase
EXW53_01240	COG2197	response regulator
EXW53_01245	COG1131	(ABC) transporter
EXW53_01250	COG1511	domain protein
EXW53_01250	COG0842	Transport permease protein
EXW53_01255	COG0842	Transport permease protein
EXW53_01265	COG0747	negative chemotaxis
EXW53_01275	COG0601	transmembrane transport
EXW53_01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW53_01285	COG0444	Belongs to the ABC transporter superfamily
EXW53_01290	COG4608	Belongs to the ABC transporter superfamily
EXW53_01295	COG0561	phosphatase activity
EXW53_01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW53_01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW53_01340	COG0531	amino acid
EXW53_01345	COG2814	Major facilitator Superfamily
EXW53_01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW53_01365	COG4294	response to UV
EXW53_01370	COG0705	Rhomboid family
EXW53_01375	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW53_01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW53_01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW53_01390	COG0864	Transcriptional regulator
EXW53_01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW53_01400	COG2183	response to ionizing radiation
EXW53_01500	COG0802	atpase or kinase
EXW53_01505	COG1214	PFAM Peptidase M22, glycoprotease
EXW53_01510	COG0456	acetyltransferase
EXW53_01520	COG0488	(ABC) transporter
EXW53_01525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW53_01535	COG1266	CAAX protease self-immunity
EXW53_01540	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW53_01545	COG0459	protein refolding
EXW53_01550	COG0519	Catalyzes the synthesis of GMP from XMP
EXW53_01550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW53_01555	COG2252	PERMEase
EXW53_01565	COG5002	protein histidine kinase activity
EXW53_01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW53_01680	COG0697	spore germination
EXW53_01705	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW53_01710	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW53_01715	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW53_01725	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW53_01730	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW53_01735	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW53_01740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW53_01750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW53_01755	COG0138	bifunctional purine biosynthesis protein purh
EXW53_01760	COG0151	Belongs to the GarS family
EXW53_01780	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW53_01785	COG0210	DNA helicase
EXW53_01790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW53_01795	COG4851	CamS sex pheromone cAM373 precursor
EXW53_01805	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_01810	COG1335	isochorismatase
EXW53_01820	COG2011	ABC-type metal ion transport system permease component
EXW53_01825	COG1464	Belongs to the NlpA lipoprotein family
EXW53_01835	COG0003	Pfam Anion-transporting ATPase
EXW53_01840	COG1846	Transcriptional regulator
EXW53_01845	COG4682	membrane
EXW53_01860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW53_01865	COG1597	lipid kinase activity
EXW53_01880	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW53_01890	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_01895	COG2076	Multidrug Resistance protein
EXW53_01905	COG2309	aminopeptidase activity
EXW53_01920	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_01930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW53_01935	COG5002	protein histidine kinase activity
EXW53_01945	COG4807	Protein conserved in bacteria
EXW53_01970	COG1757	Na H antiporter
EXW53_01975	COG1473	amidohydrolase
EXW53_01990	COG0450	alkyl hydroperoxide reductase
EXW53_02000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW53_02010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_02015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_02020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW53_02025	COG0492	ferredoxin-NADP+ reductase activity
EXW53_02035	COG0166	Belongs to the GPI family
EXW53_02060	COG5002	protein histidine kinase activity
EXW53_02075	COG3541	Predicted nucleotidyltransferase
EXW53_02080	COG0723	plastoquinol--plastocyanin reductase activity
EXW53_02080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW53_02090	COG0765	amino acid transport
EXW53_02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW53_02100	COG1126	abc transporter atp-binding protein
EXW53_02105	COG0840	transmembrane signaling receptor activity
EXW53_02110	COG0277	FAD linked oxidase domain protein
EXW53_02115	COG0366	Alpha amylase catalytic
EXW53_02120	COG1263	PTS System
EXW53_02120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW53_02120	COG2190	(PTS) system
EXW53_02140	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW53_02145	COG0352	thiamine-phosphate diphosphorylase activity
EXW53_02150	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW53_02170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW53_02180	COG1116	anion transmembrane transporter activity
EXW53_02185	COG0488	(ABC) transporter
EXW53_02225	COG2270	Major facilitator Superfamily
EXW53_02255	COG2310	stress, protein
EXW53_02260	COG2310	stress, protein
EXW53_02265	COG2310	stress, protein
EXW53_02270	COG0861	Integral membrane protein TerC family
EXW53_02280	COG3853	Toxic anion resistance protein (TelA)
EXW53_02290	COG4840	Belongs to the UPF0435 family
EXW53_02295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW53_02305	COG1295	ribonuclease BN
EXW53_02310	COG2217	Heavy metal translocating P-type atpase
EXW53_02315	COG0697	spore germination
EXW53_02335	COG0586	Pfam SNARE associated Golgi protein
EXW53_02350	COG3871	stress protein (general stress protein 26)
EXW53_02355	COG0387	Pfam Sodium calcium exchanger
EXW53_02365	COG0535	radical SAM domain protein
EXW53_02385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW53_02405	COG3829	transcription factor binding
EXW53_02415	COG0833	amino acid
EXW53_02420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW53_02445	COG1263	PTS System
EXW53_02445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW53_02450	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW53_02470	COG1215	transferase activity, transferring glycosyl groups
EXW53_02480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW53_02480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW53_02500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW53_02505	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW53_02520	COG1228	amidohydrolase
EXW53_02525	COG1090	epimerase
EXW53_02530	COG2137	regulation of response to DNA damage stimulus
EXW53_02555	COG1988	membrane-bound metal-dependent
EXW53_02560	COG1194	a g-specific adenine glycosylase
EXW53_02580	COG3557	Belongs to the UPF0374 family
EXW53_02585	COG1132	(ABC) transporter
EXW53_02590	COG4129	membrane
EXW53_02595	COG0067	glutamate synthase
EXW53_02595	COG0069	glutamate synthase activity
EXW53_02595	COG0070	glutamate synthase
EXW53_02600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW53_02605	COG4555	ABC transporter
EXW53_02625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW53_02630	COG0735	belongs to the Fur family
EXW53_02745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW53_02750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW53_02770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW53_02780	COG2766	serine protein kinase
EXW53_02785	COG2718	Belongs to the UPF0229 family
EXW53_02800	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW53_02805	COG2268	Band 7 protein
EXW53_02810	COG3290	protein histidine kinase activity
EXW53_02815	COG4565	transcriptional regulatory protein
EXW53_02820	COG2851	Citrate transporter
EXW53_02845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW53_02850	COG0745	RESPONSE REGULATOR receiver
EXW53_02855	COG5002	protein histidine kinase activity
EXW53_02865	COG4990	cell redox homeostasis
EXW53_02870	COG3290	protein histidine kinase activity
EXW53_02875	COG4565	transcriptional regulatory protein
EXW53_02880	COG3493	citrate carrier protein
EXW53_02885	COG0281	malic enzyme
EXW53_02895	COG0697	spore germination
EXW53_02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_02910	COG5002	protein histidine kinase activity
EXW53_02915	COG0745	RESPONSE REGULATOR receiver
EXW53_02920	COG0456	acetyltransferase
EXW53_02925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW53_02930	COG3383	formate dehydrogenase (NAD+) activity
EXW53_02935	COG2427	Protein of unknown function (DUF1641)
EXW53_02950	COG0531	amino acid
EXW53_02960	COG0640	Transcriptional regulator
EXW53_02965	COG2217	Heavy metal translocating P-type atpase
EXW53_02970	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW53_02985	COG3227	Zinc metalloprotease (Elastase)
EXW53_03005	COG2720	vancomycin resistance protein
EXW53_03010	COG1316	TRANSCRIPTIONal
EXW53_03015	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_03020	COG0346	lactoylglutathione lyase activity
EXW53_03025	COG1253	flavin adenine dinucleotide binding
EXW53_03030	COG1027	Aspartate ammonia-lyase
EXW53_03035	COG1620	l-lactate permease
EXW53_03040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW53_03055	COG3104	oligopeptide transport
EXW53_03060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW53_03065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_03085	COG0156	8-amino-7-oxononanoate synthase activity
EXW53_03090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW53_03095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXW53_03105	COG4548	von Willebrand factor, type A
EXW53_03110	COG0714	Associated with various cellular activities
EXW53_03135	COG0531	amino acid
EXW53_03140	COG2188	Transcriptional regulator
EXW53_03145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW53_03145	COG1263	PTS System
EXW53_03150	COG0366	Alpha amylase catalytic
EXW53_03170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW53_03175	COG1115	amino acid carrier protein
EXW53_03180	COG1126	abc transporter atp-binding protein
EXW53_03185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW53_03190	COG0765	amino acid transport
EXW53_03195	COG0765	amino acid transport
EXW53_03200	COG0833	amino acid
EXW53_03225	COG2378	regulation of single-species biofilm formation
EXW53_03230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW53_03235	COG5002	protein histidine kinase activity
EXW53_03250	COG0659	secondary active sulfate transmembrane transporter activity
EXW53_03265	COG0747	negative chemotaxis
EXW53_03275	COG0601	transmembrane transport
EXW53_03280	COG4608	Belongs to the ABC transporter superfamily
EXW53_03290	COG2271	Major facilitator Superfamily
EXW53_03295	COG1846	Transcriptional regulator
EXW53_03300	COG0477	Major facilitator Superfamily
EXW53_03305	COG1609	Transcriptional regulator
EXW53_03310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW53_03315	COG1869	D-ribose catabolic process
EXW53_03325	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW53_03330	COG1879	ABC-type sugar transport system periplasmic component
EXW53_03360	COG1063	alcohol dehydrogenase
EXW53_03410	COG0840	transmembrane signaling receptor activity
EXW53_03415	COG1388	LysM domain
EXW53_03415	COG3584	3D domain protein
EXW53_03420	COG1476	TRANSCRIPTIONal
EXW53_03440	COG3104	oligopeptide transport
EXW53_03445	COG1114	Component of the transport system for branched-chain amino acids
EXW53_03460	COG1113	amino acid transport
EXW53_03465	COG2252	PERMEase
EXW53_03480	COG2153	protein acetylation
EXW53_03490	COG0475	glutathione-regulated potassium exporter activity
EXW53_03490	COG0569	domain protein
EXW53_03500	COG1845	cytochrome c oxidase, subunit III
EXW53_03505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW53_03510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EXW53_03515	COG0833	amino acid
EXW53_03520	COG4990	cell redox homeostasis
EXW53_03535	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW53_03540	COG0697	spore germination
EXW53_03545	COG0531	amino acid
EXW53_03560	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW53_03565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW53_03575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW53_03580	COG0573	inorganic phosphate transmembrane transporter activity
EXW53_03585	COG0581	inorganic phosphate transmembrane transporter activity
EXW53_03595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW53_03640	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW53_03720	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW53_03735	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW53_03735	COG3103	Sh3 type 3 domain protein
EXW53_03735	COG4991	sh3 domain protein
EXW53_03740	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW53_03745	COG1116	anion transmembrane transporter activity
EXW53_03750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW53_03755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW53_03760	COG0352	thiamine-phosphate diphosphorylase activity
EXW53_03765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW53_03770	COG2104	thiamine diphosphate biosynthetic process
EXW53_03780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW53_03785	COG0351	phosphomethylpyrimidine kinase
EXW53_03815	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW53_03820	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW53_03825	COG2205	protein histidine kinase activity
EXW53_03860	COG1136	(ABC) transporter
EXW53_03870	COG2252	PERMEase
EXW53_03875	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_03935	COG0778	Nitroreductase
EXW53_03940	COG2719	SpoVR family
EXW53_03970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW53_03980	COG1937	Protein conserved in bacteria
EXW53_03985	COG0425	Belongs to the sulfur carrier protein TusA family
EXW53_03985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW53_03990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW53_03990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_03995	COG0425	Belongs to the sulfur carrier protein TusA family
EXW53_04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW53_04005	COG2210	Belongs to the sulfur carrier protein TusA family
EXW53_04010	COG0730	response to heat
EXW53_04020	COG1316	TRANSCRIPTIONal
EXW53_04025	COG0604	alcohol dehydrogenase
EXW53_04030	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW53_04040	COG2814	Major facilitator Superfamily
EXW53_04050	COG3711	transcriptional antiterminator
EXW53_04050	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW53_04055	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW53_04060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW53_04085	COG1388	LysM domain
EXW53_04085	COG3584	3D domain protein
EXW53_04090	COG1396	sequence-specific DNA binding
EXW53_04100	COG4824	toxin secretion phage lysis holin
EXW53_04110	COG0791	NLP P60 protein
EXW53_04110	COG1388	LysM domain
EXW53_04115	COG3584	3D domain protein
EXW53_04115	COG3583	domain protein
EXW53_04120	COG0577	efflux transmembrane transporter activity
EXW53_04125	COG1136	(ABC) transporter
EXW53_04135	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW53_04150	COG1114	Component of the transport system for branched-chain amino acids
EXW53_04155	COG3546	catalase activity
EXW53_04185	COG0586	Pfam SNARE associated Golgi protein
EXW53_04215	COG0531	amino acid
EXW53_04220	COG0475	glutathione-regulated potassium exporter activity
EXW53_04230	COG1737	Transcriptional regulator
EXW53_04235	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW53_04240	COG1263	PTS System
EXW53_04240	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW53_04250	COG2259	Doxx family
EXW53_04285	COG0531	amino acid
EXW53_04295	COG0351	phosphomethylpyrimidine kinase
EXW53_04300	COG1757	Na H antiporter
EXW53_04305	COG4496	protein, YerC YecD
EXW53_04320	COG1522	sequence-specific DNA binding
EXW53_04330	COG0300	oxidoreductase activity
EXW53_04345	COG2076	Multidrug Resistance protein
EXW53_04350	COG1309	transcriptional regulator
EXW53_04355	COG2814	Major facilitator Superfamily
EXW53_04360	COG1733	regulation of RNA biosynthetic process
EXW53_04370	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW53_04380	COG4533	DNA binding
EXW53_04385	COG2211	Major facilitator Superfamily
EXW53_04395	COG4473	ABC transporter
EXW53_04400	COG0531	amino acid
EXW53_04410	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_04415	COG1132	(ABC) transporter
EXW53_04420	COG1132	(ABC) transporter
EXW53_04425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW53_04430	COG0765	amino acid transport
EXW53_04435	COG1126	abc transporter atp-binding protein
EXW53_04450	COG0189	ligase activity
EXW53_04460	COG4399	Belongs to the UPF0754 family
EXW53_04465	COG3679	Belongs to the UPF0342 family
EXW53_04470	COG0463	Glycosyl transferase, family 2
EXW53_04475	COG1216	Glycosyl transferase, family 2
EXW53_04480	COG2094	Belongs to the DNA glycosylase MPG family
EXW53_04485	COG0561	phosphatase activity
EXW53_04490	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW53_04490	COG3409	Peptidoglycan-binding domain 1 protein
EXW53_04495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW53_04500	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_04510	COG0586	Pfam SNARE associated Golgi protein
EXW53_04520	COG0789	Transcriptional regulator
EXW53_04520	COG4978	Transcriptional regulator
EXW53_04530	COG0659	secondary active sulfate transmembrane transporter activity
EXW53_04535	COG2244	polysaccharide biosynthetic process
EXW53_04555	COG1024	Enoyl-CoA hydratase
EXW53_04570	COG1363	Peptidase, m42
EXW53_04595	COG1113	amino acid transport
EXW53_04600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW53_04620	COG0579	oxidoreductase
EXW53_04625	COG2226	methyltransferase
EXW53_04630	COG3829	transcription factor binding
EXW53_04630	COG3290	protein histidine kinase activity
EXW53_04640	COG1301	dicarboxylic acid transport
EXW53_04660	COG0601	transmembrane transport
EXW53_04665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW53_04670	COG0444	Belongs to the ABC transporter superfamily
EXW53_04675	COG4608	Belongs to the ABC transporter superfamily
EXW53_04780	COG3181	Tripartite tricarboxylate transporter family receptor
EXW53_04785	COG0519	Catalyzes the synthesis of GMP from XMP
EXW53_04800	COG0582	viral genome integration into host DNA
EXW53_04835	COG1002	Type II restriction enzyme, methylase subunits
EXW53_04840	COG1061	Type III restriction enzyme res subunit
EXW53_04845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW53_04860	COG0305	Participates in initiation and elongation during chromosome replication
EXW53_04890	COG1842	Phage shock protein A
EXW53_04900	COG0477	Major facilitator Superfamily
EXW53_04945	COG1183	phosphatidylcholine synthase activity
EXW53_04950	COG0586	Pfam SNARE associated Golgi protein
EXW53_04965	COG2814	Major facilitator Superfamily
EXW53_04970	COG0640	Transcriptional regulator
EXW53_05000	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW53_05055	COG2376	Dihydroxyacetone kinase
EXW53_05075	COG2376	Dihydroxyacetone kinase
EXW53_05100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW53_05100	COG2755	lipolytic protein G-D-S-L family
EXW53_05115	COG1335	isochorismatase
EXW53_05120	COG2373	Large extracellular alpha-helical protein
EXW53_05125	COG0596	Alpha beta hydrolase
EXW53_05160	COG2807	transmembrane transport
EXW53_05165	COG2186	Transcriptional regulator
EXW53_05180	COG4585	Histidine kinase
EXW53_05185	COG2197	response regulator
EXW53_05210	COG0420	3'-5' exonuclease activity
EXW53_05215	COG4717	serine-type aminopeptidase activity
EXW53_05220	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW53_05225	COG0346	lactoylglutathione lyase activity
EXW53_05230	COG2267	carboxylic ester hydrolase activity
EXW53_05240	COG2140	Oxalate decarboxylase
EXW53_05245	COG3620	sequence-specific DNA binding
EXW53_05250	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW53_05255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW53_05260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW53_05265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW53_05270	COG1595	DNA-templated transcription, initiation
EXW53_05285	COG1309	transcriptional regulator
EXW53_05290	COG2814	Major facilitator Superfamily
EXW53_05295	COG3973	AAA domain
EXW53_05325	COG0537	adenosine 5'-monophosphoramidase activity
EXW53_05330	COG1131	(ABC) transporter
EXW53_05335	COG4473	ABC transporter
EXW53_05350	COG0247	lactate metabolic process
EXW53_05355	COG1139	Iron-sulfur cluster binding protein
EXW53_05360	COG1556	Lactate utilization protein
EXW53_05375	COG3402	PFAM membrane-flanked domain
EXW53_05380	COG3428	Bacterial PH domain
EXW53_05405	COG3402	PFAM membrane-flanked domain
EXW53_05410	COG3428	Bacterial PH domain
EXW53_05415	COG2329	Antibiotic biosynthesis monooxygenase
EXW53_05420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW53_05430	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW53_05435	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW53_05470	COG1309	transcriptional regulator
EXW53_05475	COG1511	domain protein
EXW53_05480	COG1216	Glycosyl transferase, family 2
EXW53_05480	COG0438	transferase activity, transferring glycosyl groups
EXW53_05500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_05510	COG2378	regulation of single-species biofilm formation
EXW53_05515	COG1609	Transcriptional regulator
EXW53_05525	COG1234	tRNA 3'-trailer cleavage
EXW53_05530	COG0095	Lipoate-protein ligase
EXW53_05540	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_05550	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW53_05560	COG4208	sulfate ABC transporter
EXW53_05590	COG1408	metallophosphoesterase
EXW53_05595	COG1078	dGTPase activity
EXW53_05610	COG1595	DNA-templated transcription, initiation
EXW53_05615	COG2207	Transcriptional regulator
EXW53_05615	COG3708	Transcriptional regulator
EXW53_05620	COG2205	protein histidine kinase activity
EXW53_05625	COG0745	RESPONSE REGULATOR receiver
EXW53_05650	COG0501	Belongs to the peptidase M48B family
EXW53_05655	COG0697	spore germination
EXW53_05670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW53_05675	COG2224	Isocitrate lyase
EXW53_05685	COG1278	Cold shock
EXW53_05700	COG4903	ComK protein
EXW53_05705	COG0398	Pfam SNARE associated Golgi protein
EXW53_05715	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW53_05720	COG1074	ATP-dependent DNA helicase activity
EXW53_05775	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW53_05800	COG0367	asparagine synthase
EXW53_05810	COG0753	catalase activity
EXW53_05815	COG0004	ammonium transporteR
EXW53_05830	COG1666	GTP binding
EXW53_05835	COG2996	Protein conserved in bacteria
EXW53_05840	COG3209	COG3209 Rhs family protein
EXW53_05890	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW53_05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_05915	COG0561	phosphatase activity
EXW53_05935	COG2267	carboxylic ester hydrolase activity
EXW53_05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW53_05955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW53_05960	COG5504	Zn-dependent protease
EXW53_05970	COG0180	Tryptophanyl-tRNA synthetase
EXW53_05980	COG4166	transmembrane transport
EXW53_05985	COG0601	transmembrane transport
EXW53_05990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW53_05995	COG0444	Belongs to the ABC transporter superfamily
EXW53_06000	COG4608	Belongs to the ABC transporter superfamily
EXW53_06005	COG0534	Mate efflux family protein
EXW53_06010	COG4166	transmembrane transport
EXW53_06025	COG0861	Integral membrane protein TerC family
EXW53_06030	COG4862	establishment of competence for transformation
EXW53_06035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW53_06045	COG1164	Oligoendopeptidase f
EXW53_06060	COG2346	COG2346, Truncated hemoglobins
EXW53_06065	COG4116	CYTH
EXW53_06075	COG2357	RelA SpoT domain protein
EXW53_06085	COG0564	pseudouridine synthase activity
EXW53_06095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW53_06100	COG0772	Belongs to the SEDS family
EXW53_06110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW53_06125	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW53_06170	COG2153	protein acetylation
EXW53_06175	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW53_06180	COG2382	esterase
EXW53_06205	COG5492	domain, Protein
EXW53_06210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW53_06220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW53_06220	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW53_06225	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW53_06230	COG0134	indole-3-glycerol-phosphate synthase activity
EXW53_06235	COG0135	phosphoribosylanthranilate isomerase activity
EXW53_06240	COG0133	tryptophan synthase activity
EXW53_06245	COG0159	tryptophan synthase activity
EXW53_06255	COG1620	l-lactate permease
EXW53_06260	COG5634	Uncharacterized conserved protein (DUF2278)
EXW53_06295	COG2226	methyltransferase
EXW53_06315	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW53_06320	COG0567	Dehydrogenase, E1 component
EXW53_06325	COG1476	TRANSCRIPTIONal
EXW53_06370	COG4581	dead DEAH box helicase
EXW53_06390	COG1686	Belongs to the peptidase S11 family
EXW53_06395	COG0681	Belongs to the peptidase S26 family
EXW53_06430	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_06440	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW53_06445	COG1177	transmembrane transport
EXW53_06450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW53_06460	COG2409	Drug exporters of the RND superfamily
EXW53_06470	COG0564	pseudouridine synthase activity
EXW53_06480	COG2340	Cysteine-rich secretory protein family
EXW53_06485	COG0247	lactate metabolic process
EXW53_06490	COG0277	FAD linked oxidase domain protein
EXW53_06495	COG3835	regulator
EXW53_06505	COG0745	RESPONSE REGULATOR receiver
EXW53_06510	COG3850	Histidine kinase
EXW53_06510	COG5002	protein histidine kinase activity
EXW53_06515	COG2186	Transcriptional regulator
EXW53_06530	COG1556	Lactate utilization protein
EXW53_06535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW53_06550	COG0583	DNA-binding transcription factor activity
EXW53_06565	COG0825	malonyl-CoA metabolic process
EXW53_06585	COG2116	formate transmembrane transporter activity
EXW53_06590	COG0861	Integral membrane protein TerC family
EXW53_06595	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW53_06605	COG2030	dehydratase
EXW53_06625	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_06630	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW53_06640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW53_06655	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW53_06660	COG3842	ATPase activity
EXW53_06670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW53_06675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW53_06685	COG1349	DNA-binding transcription factor activity
EXW53_06695	COG0235	Class ii aldolase
EXW53_06705	COG2861	carbohydrate metabolic process
EXW53_06715	COG3852	Histidine kinase
EXW53_06720	COG1846	Transcriptional regulator
EXW53_06730	COG2318	DinB family
EXW53_06740	COG5002	protein histidine kinase activity
EXW53_06750	COG0720	synthase
EXW53_06765	COG4873	Protein conserved in bacteria
EXW53_06780	COG0456	acetyltransferase
EXW53_06795	COG1780	Probably involved in ribonucleotide reductase function
EXW53_06810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW53_06815	COG0531	amino acid
EXW53_06830	COG2204	response regulator
EXW53_06835	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_06845	COG1725	Transcriptional regulator
EXW53_06850	COG1131	(ABC) transporter
EXW53_06860	COG1131	(ABC) transporter
EXW53_06865	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW53_06870	COG1266	CAAX protease self-immunity
EXW53_06880	COG1522	sequence-specific DNA binding
EXW53_06890	COG1335	isochorismatase
EXW53_06900	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW53_06905	COG2070	2-Nitropropane dioxygenase
EXW53_06910	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW53_06915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW53_06920	COG1696	Membrane protein involved in D-alanine export
EXW53_06945	COG0716	FMN binding
EXW53_06960	COG3173	Aminoglycoside phosphotransferase
EXW53_06980	COG0534	Mate efflux family protein
EXW53_07005	COG1846	Transcriptional regulator
EXW53_07020	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW53_07030	COG3874	Sporulation protein YtfJ
EXW53_07050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW53_07055	COG0028	Belongs to the TPP enzyme family
EXW53_07060	COG0440	acetolactate synthase activity
EXW53_07070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW53_07080	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW53_07090	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW53_07095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW53_07105	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW53_07110	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW53_07115	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW53_07120	COG0107	imidazoleglycerol-phosphate synthase activity
EXW53_07135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW53_07150	COG1183	phosphatidylcholine synthase activity
EXW53_07155	COG1368	sulfuric ester hydrolase activity
EXW53_07165	COG0019	diaminopimelate decarboxylase activity
EXW53_07180	COG2046	Belongs to the sulfate adenylyltransferase family
EXW53_07185	COG0529	Catalyzes the synthesis of activated sulfate
EXW53_07190	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW53_07210	COG1648	precorrin-2 dehydrogenase activity
EXW53_07215	COG0733	neurotransmitter:sodium symporter activity
EXW53_07240	COG1757	Na H antiporter
EXW53_07255	COG4758	membrane
EXW53_07260	COG4585	Histidine kinase
EXW53_07265	COG2197	response regulator
EXW53_07275	COG1114	Component of the transport system for branched-chain amino acids
EXW53_07325	COG0730	response to heat
EXW53_07330	COG0306	phosphate transporter
EXW53_07335	COG1392	Phosphate transport regulator
EXW53_07340	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW53_07355	COG3852	Histidine kinase
EXW53_07360	COG1801	Protein of unknown function DUF72
EXW53_07370	COG0582	viral genome integration into host DNA
EXW53_07375	COG5002	protein histidine kinase activity
EXW53_07390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW53_07390	COG0392	lysyltransferase activity
EXW53_07405	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW53_07410	COG1686	Belongs to the peptidase S11 family
EXW53_07415	COG2715	membrane protein required for spore maturation
EXW53_07420	COG0700	Nucleoside recognition
EXW53_07425	COG1187	pseudouridine synthase activity
EXW53_07435	COG1333	cytochrome c biogenesis protein
EXW53_07440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW53_07445	COG0745	RESPONSE REGULATOR receiver
EXW53_07450	COG5002	protein histidine kinase activity
EXW53_07455	COG2096	Adenosyltransferase
EXW53_07460	COG4942	peptidase
EXW53_07470	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW53_07475	COG1141	Ferredoxin
EXW53_07480	COG4955	Helix-turn-helix domain
EXW53_07485	COG0514	ATP-dependent DNA helicase (RecQ)
EXW53_07490	COG1266	CAAX protease self-immunity
EXW53_07500	COG1408	metallophosphoesterase
EXW53_07515	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW53_07530	COG0492	ferredoxin-NADP+ reductase activity
EXW53_07535	COG0252	asparaginase activity
EXW53_07545	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW53_07555	COG1304	FMN binding
EXW53_07590	COG1160	GTP binding
EXW53_07615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW53_07630	COG0142	geranyltranstransferase activity
EXW53_07635	COG2226	methyltransferase
EXW53_07640	COG0142	geranyltranstransferase activity
EXW53_07655	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW53_07665	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW53_07670	COG0457	Tetratricopeptide repeat
EXW53_07675	COG5582	Belongs to the UPF0302 family
EXW53_07690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW53_07695	COG2010	Cytochrome c
EXW53_07695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW53_07700	COG4347	Protein of unknown function (DUF1405)
EXW53_07715	COG2738	Putative neutral zinc metallopeptidase
EXW53_07725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_07735	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW53_07740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW53_07745	COG1803	Methylglyoxal synthase
EXW53_07750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW53_07755	COG0438	transferase activity, transferring glycosyl groups
EXW53_07760	COG0617	tRNA 3'-terminal CCA addition
EXW53_07770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW53_07775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW53_07785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW53_07785	COG1199	ATP-dependent helicase activity
EXW53_07805	COG3935	DnaD domain protein
EXW53_07810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW53_07820	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW53_07820	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW53_07825	COG3331	DNA recombination
EXW53_07860	COG4474	Belongs to the UPF0398 family
EXW53_07865	COG3599	regulation of cell shape
EXW53_07875	COG0116	Belongs to the methyltransferase superfamily
EXW53_07885	COG1199	ATP-dependent helicase activity
EXW53_07890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW53_07900	COG0024	Methionine aminopeptidase
EXW53_07910	COG2233	PERMEase
EXW53_07915	COG2311	Membrane
EXW53_07925	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW53_07935	COG0456	acetyltransferase
EXW53_07945	COG2897	thiosulfate sulfurtransferase activity
EXW53_07985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW53_08005	COG0454	-acetyltransferase
EXW53_08025	COG0328	RNA-DNA hybrid ribonuclease activity
EXW53_08060	COG3403	YqcI/YcgG family
EXW53_08065	COG1280	lysine exporter protein (LysE YggA)
EXW53_08080	COG3162	membrane
EXW53_08085	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW53_08090	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW53_08100	COG0475	glutathione-regulated potassium exporter activity
EXW53_08105	COG0789	Transcriptional regulator
EXW53_08105	COG4978	Transcriptional regulator
EXW53_08110	COG0534	Mate efflux family protein
EXW53_08115	COG2323	membrane
EXW53_08120	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW53_08140	COG1609	Transcriptional regulator
EXW53_08150	COG1175	transmembrane transport
EXW53_08155	COG0395	ABC-type sugar transport system, permease component
EXW53_08160	COG5578	integral membrane protein
EXW53_08170	COG1486	melibiose metabolic process
EXW53_08185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EXW53_08190	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EXW53_08195	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW53_08230	COG1923	regulation of RNA biosynthetic process
EXW53_08240	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW53_08245	COG1360	Flagellar Motor Protein
EXW53_08250	COG2201	protein-glutamate methylesterase activity
EXW53_08255	COG0643	Histidine kinase
EXW53_08255	COG2198	Histidine kinase
EXW53_08260	COG1776	CheC inhibitor of MCP methylation
EXW53_08260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW53_08275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW53_08295	COG1256	bacterial-type flagellum assembly
EXW53_08305	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EXW53_08320	COG1815	bacterial-type flagellum-dependent cell motility
EXW53_08325	COG1558	bacterial-type flagellum-dependent cell motility
EXW53_08335	COG1766	The M ring may be actively involved in energy transduction
EXW53_08340	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW53_08350	COG1157	protein secretion by the type III secretion system
EXW53_08370	COG1749	Flagellar hook protein flgE
EXW53_08385	COG0835	chemotaxis
EXW53_08385	COG0784	Response regulator, receiver
EXW53_08395	COG0861	Integral membrane protein TerC family
EXW53_08405	COG3383	formate dehydrogenase (NAD+) activity
EXW53_08410	COG2427	Protein of unknown function (DUF1641)
EXW53_08415	COG5609	conserved protein (DUF2294)
EXW53_08420	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW53_08430	COG2116	formate transmembrane transporter activity
EXW53_08435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW53_08440	COG0303	'Molybdopterin
EXW53_08445	COG0314	molybdopterin synthase activity
EXW53_08450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW53_08460	COG0489	protein tyrosine kinase activity
EXW53_08465	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW53_08470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW53_08475	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW53_08480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW53_08485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW53_08490	COG0741	lytic transglycosylase activity
EXW53_08500	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW53_08505	COG1776	CheC inhibitor of MCP methylation
EXW53_08505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW53_08515	COG1338	Plays a role in the flagellum-specific transport system
EXW53_08520	COG1987	bacterial-type flagellum assembly
EXW53_08530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW53_08535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW53_08540	COG1419	protein localization to endoplasmic reticulum
EXW53_08545	COG4786	Flagellar basal body rod
EXW53_08580	COG0412	Dienelactone hydrolase
EXW53_08585	COG2329	Antibiotic biosynthesis monooxygenase
EXW53_08600	COG3764	Sortase (surface protein transpeptidase)
EXW53_08605	COG3764	Sortase (surface protein transpeptidase)
EXW53_08630	COG0583	DNA-binding transcription factor activity
EXW53_08635	COG3842	ATPase activity
EXW53_08695	COG1846	Transcriptional regulator
EXW53_08705	COG0367	asparagine synthase
EXW53_08735	COG1757	Na H antiporter
EXW53_08745	COG0277	FAD linked oxidase domain protein
EXW53_08765	COG0534	Mate efflux family protein
EXW53_08770	COG3340	Belongs to the peptidase S51 family
EXW53_08790	COG0785	Cytochrome C biogenesis protein
EXW53_08810	COG3048	D-serine ammonia-lyase activity
EXW53_08815	COG2733	membrane
EXW53_08850	COG1131	(ABC) transporter
EXW53_08870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW53_08880	COG0457	Tetratricopeptide repeat
EXW53_08890	COG3157	Type VI secretion system effector, Hcp
EXW53_08910	COG0528	UMP kinase activity
EXW53_08920	COG1027	Aspartate ammonia-lyase
EXW53_08925	COG0281	malic enzyme
EXW53_08930	COG4191	Histidine kinase
EXW53_08935	COG0784	Response regulator, receiver
EXW53_08940	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW53_08950	COG2502	aspartate--ammonia ligase
EXW53_09015	COG1595	DNA-templated transcription, initiation
EXW53_09035	COG0477	Major facilitator Superfamily
EXW53_09055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW53_09060	COG2223	nitrite transmembrane transporter activity
EXW53_09065	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW53_09080	COG2244	polysaccharide biosynthetic process
EXW53_09085	COG0733	neurotransmitter:sodium symporter activity
EXW53_09095	COG5566	PFAM Mor transcription activator
EXW53_09100	COG2323	membrane
EXW53_09115	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW53_09130	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW53_09140	COG1811	Na channel or pump
EXW53_09150	COG2814	Major facilitator Superfamily
EXW53_09155	COG3384	dioxygenase
EXW53_09210	COG4166	transmembrane transport
EXW53_09215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_09225	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW53_09230	COG1054	Belongs to the UPF0176 family
EXW53_09240	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW53_09245	COG0531	amino acid
EXW53_09265	COG1280	lysine exporter protein (LysE YggA)
EXW53_09280	COG2390	Transcriptional regulator
EXW53_09285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW53_09290	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_09295	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW53_09310	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW53_09320	COG0006	proline dipeptidase activity
EXW53_09325	COG2132	Multicopper oxidase
EXW53_09335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW53_09345	COG0583	DNA-binding transcription factor activity
EXW53_09365	COG1114	Component of the transport system for branched-chain amino acids
EXW53_09375	COG1276	copper resistance
EXW53_09375	COG2372	response to copper ion
EXW53_09380	COG4549	nuclear export factor GLE1
EXW53_09385	COG0697	spore germination
EXW53_09390	COG0583	DNA-binding transcription factor activity
EXW53_09395	COG1959	2 iron, 2 sulfur cluster binding
EXW53_09400	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW53_09405	COG0778	Nitroreductase
EXW53_09415	COG0628	permease
EXW53_09430	COG1231	oxidoreductase activity
EXW53_09435	COG0523	cobalamin synthesis protein
EXW53_09450	COG2030	dehydratase
EXW53_09455	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW53_09470	COG0411	ABC transporter
EXW53_09490	COG0583	DNA-binding transcription factor activity
EXW53_09500	COG1942	4-Oxalocrotonate Tautomerase
EXW53_09515	COG0346	lactoylglutathione lyase activity
EXW53_09525	COG1271	oxidase subunit
EXW53_09530	COG1294	oxidase, subunit
EXW53_09535	COG4988	ABC transporter
EXW53_09540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW53_09570	COG1686	Belongs to the peptidase S11 family
EXW53_09585	COG0791	NLP P60 protein
EXW53_09585	COG1388	LysM domain
EXW53_09595	COG1132	(ABC) transporter
EXW53_09600	COG0745	RESPONSE REGULATOR receiver
EXW53_09605	COG5002	protein histidine kinase activity
EXW53_09615	COG0300	oxidoreductase activity
EXW53_09620	COG4122	O-methyltransferase activity
EXW53_09650	COG0460	homoserine dehydrogenase
EXW53_09660	COG0083	homoserine kinase activity
EXW53_09675	COG1316	TRANSCRIPTIONal
EXW53_09690	COG1285	pathogenesis
EXW53_09695	COG1247	-acetyltransferase
EXW53_09715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW53_09725	COG1082	Xylose isomerase domain protein TIM barrel
EXW53_09735	COG2814	Major facilitator Superfamily
EXW53_09740	COG1279	arginine transmembrane transporter activity
EXW53_09745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_09755	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW53_09790	COG0577	efflux transmembrane transporter activity
EXW53_09795	COG2002	toxin-antitoxin pair type II binding
EXW53_09800	COG1404	Belongs to the peptidase S8 family
EXW53_09810	COG3842	ATPase activity
EXW53_09815	COG2508	Transcriptional regulator
EXW53_09825	COG1653	transport
EXW53_09830	COG1175	transmembrane transport
EXW53_09835	COG0395	ABC-type sugar transport system, permease component
EXW53_09840	COG5426	von Willebrand factor, type A
EXW53_09850	COG1940	carbohydrate kinase activity
EXW53_09855	COG2222	sugar isomerase
EXW53_09865	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW53_09870	COG3684	Belongs to the aldolase LacD family
EXW53_09875	COG0366	Alpha amylase catalytic
EXW53_09880	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
EXW53_09925	COG3949	Membrane
EXW53_09930	COG0783	Belongs to the Dps family
EXW53_09945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW53_09955	COG1231	oxidoreductase activity
EXW53_09960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_09965	COG4989	oxidoreductase activity
EXW53_09970	COG0523	cobalamin synthesis protein
EXW53_09975	COG0456	acetyltransferase
EXW53_09980	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW53_09990	COG0702	epimerase
EXW53_10000	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW53_10010	COG4166	transmembrane transport
EXW53_10015	COG0346	lactoylglutathione lyase activity
EXW53_10025	COG0406	alpha-ribazole phosphatase activity
EXW53_10035	COG5337	Spore coat protein CotH
EXW53_10040	COG1051	belongs to the nudix hydrolase family
EXW53_10045	COG0586	Pfam SNARE associated Golgi protein
EXW53_10050	COG2244	polysaccharide biosynthetic process
EXW53_10060	COG0701	Predicted permease
EXW53_10065	COG3689	TIGRFAM TIGR03943 family protein
EXW53_10070	COG1607	acyl-coa hydrolase
EXW53_10080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW53_10095	COG0702	epimerase
EXW53_10100	COG2839	Protein conserved in bacteria
EXW53_10105	COG1253	flavin adenine dinucleotide binding
EXW53_10120	COG1114	Component of the transport system for branched-chain amino acids
EXW53_10125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW53_10140	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW53_10150	COG1876	peptidase activity
EXW53_10180	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW53_10190	COG0561	phosphatase activity
EXW53_10200	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW53_10215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_10220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_10245	COG0456	acetyltransferase
EXW53_10280	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW53_10420	COG3874	Sporulation protein YtfJ
EXW53_10445	COG2226	methyltransferase
EXW53_10465	COG0346	lactoylglutathione lyase activity
EXW53_10475	COG0604	alcohol dehydrogenase
EXW53_10480	COG1595	DNA-templated transcription, initiation
EXW53_10515	COG0386	Belongs to the glutathione peroxidase family
EXW53_10520	COG1305	Transglutaminase-like
EXW53_10525	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW53_10530	COG0714	Associated with various cellular activities
EXW53_10545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW53_10550	COG1140	nitrate reductase beta subunit
EXW53_10555	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW53_10560	COG2181	nitrate reductase activity
EXW53_10565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW53_10570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW53_10575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW53_10580	COG0303	'Molybdopterin
EXW53_10585	COG0314	molybdopterin synthase activity
EXW53_10595	COG2223	nitrite transmembrane transporter activity
EXW53_10605	COG1648	precorrin-2 dehydrogenase activity
EXW53_10615	COG1587	Uroporphyrinogen-III synthase
EXW53_10615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW53_10620	COG2146	nitrite reductase [NAD(P)H] activity
EXW53_10625	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW53_10630	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW53_10660	COG2359	stage V sporulation protein S
EXW53_10695	COG0582	viral genome integration into host DNA
EXW53_10720	COG1418	mRNA catabolic process
EXW53_10725	COG0488	(ABC) transporter
EXW53_10745	COG1413	lyase activity
EXW53_10760	COG2136	Putative SAM-dependent methyltransferase
EXW53_10760	COG2521	methyltransferase
EXW53_10765	COG0018	arginyl-trna synthetase
EXW53_10815	COG0017	Asparaginyl-tRNA synthetase
EXW53_10850	COG0733	neurotransmitter:sodium symporter activity
EXW53_10875	COG2610	gluconate transmembrane transporter activity
EXW53_10890	COG0456	acetyltransferase
EXW53_10895	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW53_10900	COG1131	(ABC) transporter
EXW53_10905	COG4473	ABC transporter
EXW53_10915	COG0546	phosphoglycolate phosphatase activity
EXW53_10940	COG0671	phosphoesterase, PA-phosphatase related
EXW53_10960	COG0768	penicillin binding
EXW53_10975	COG1272	protein, Hemolysin III
EXW53_10980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW53_10985	COG0805	protein transport
EXW53_10995	COG1307	EDD domain protein, DegV family
EXW53_11000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW53_11005	COG1999	signal sequence binding
EXW53_11010	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW53_11015	COG0367	asparagine synthase
EXW53_11030	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW53_11035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW53_11040	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW53_11060	COG1335	isochorismatase
EXW53_11065	COG1051	belongs to the nudix hydrolase family
EXW53_11070	COG0668	transmembrane transport
EXW53_11075	COG4585	Histidine kinase
EXW53_11075	COG2203	Gaf domain
EXW53_11080	COG2197	response regulator
EXW53_11085	COG1737	Transcriptional regulator
EXW53_11090	COG1064	alcohol dehydrogenase
EXW53_11105	COG1070	Carbohydrate kinase
EXW53_11115	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW53_11135	COG1125	glycine betaine transport
EXW53_11135	COG0517	IMP dehydrogenase activity
EXW53_11140	COG1174	glycine betaine transport
EXW53_11175	COG1253	flavin adenine dinucleotide binding
EXW53_11180	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_11185	COG5506	Protein of unknown function (DUF1694)
EXW53_11200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW53_11205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW53_11210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW53_11215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW53_11220	COG0456	acetyltransferase
EXW53_11225	COG3829	transcription factor binding
EXW53_11230	COG1509	lysine 2,3-aminomutase activity
EXW53_11240	COG4479	Belongs to the UPF0346 family
EXW53_11265	COG0515	serine threonine protein kinase
EXW53_11265	COG3064	Membrane
EXW53_11265	COG4991	sh3 domain protein
EXW53_11275	COG0671	phosphoesterase, PA-phosphatase related
EXW53_11280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW53_11285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW53_11350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW53_11380	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_11400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW53_11400	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW53_11410	COG2814	Major facilitator Superfamily
EXW53_11420	COG0372	Belongs to the citrate synthase family
EXW53_11425	COG2079	MmgE PrpD family protein
EXW53_11430	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW53_11435	COG1960	acyl-CoA dehydrogenase activity
EXW53_11440	COG2084	Dehydrogenase
EXW53_11445	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_11450	COG1280	lysine exporter protein (LysE YggA)
EXW53_11455	COG1024	Enoyl-CoA hydratase
EXW53_11470	COG0420	3'-5' exonuclease activity
EXW53_11495	COG2223	nitrite transmembrane transporter activity
EXW53_11500	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_11505	COG1169	isochorismate synthase
EXW53_11510	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW53_11515	COG1535	isochorismatase
EXW53_11515	COG3433	isochorismatase activity
EXW53_11520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW53_11525	COG3251	PFAM MbtH domain protein
EXW53_11530	COG2814	Major facilitator Superfamily
EXW53_11545	COG0776	regulation of translation
EXW53_11555	COG2318	DinB family
EXW53_11560	COG1115	amino acid carrier protein
EXW53_11575	COG2329	Antibiotic biosynthesis monooxygenase
EXW53_11585	COG1187	pseudouridine synthase activity
EXW53_11590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW53_11605	COG1136	(ABC) transporter
EXW53_11615	COG0596	Alpha beta hydrolase
EXW53_11635	COG0028	Belongs to the TPP enzyme family
EXW53_11645	COG4974	Belongs to the 'phage' integrase family
EXW53_11665	COG1253	flavin adenine dinucleotide binding
EXW53_11685	COG2267	carboxylic ester hydrolase activity
EXW53_11710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_11715	COG1309	transcriptional regulator
EXW53_11725	COG0697	spore germination
EXW53_11730	COG0531	amino acid
EXW53_11750	COG1247	-acetyltransferase
EXW53_11785	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW53_11805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_11830	COG0561	phosphatase activity
EXW53_11840	COG0583	DNA-binding transcription factor activity
EXW53_11845	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW53_11880	COG0583	DNA-binding transcription factor activity
EXW53_11885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW53_11890	COG2258	MOSC domain
EXW53_11905	COG1132	(ABC) transporter
EXW53_11910	COG1132	(ABC) transporter
EXW53_11915	COG0582	viral genome integration into host DNA
EXW53_11925	COG0189	ligase activity
EXW53_11945	COG1396	sequence-specific DNA binding
EXW53_12030	COG0500	methyltransferase
EXW53_12030	COG3615	Tellurite resistance protein tehB
EXW53_12040	COG0693	protein deglycase activity
EXW53_12050	COG0588	phosphoglycerate mutase activity
EXW53_12070	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW53_12105	COG1686	Belongs to the peptidase S11 family
EXW53_12150	COG0768	penicillin binding
EXW53_12155	COG1595	DNA-templated transcription, initiation
EXW53_12165	COG0768	penicillin binding
EXW53_12170	COG0768	penicillin binding
EXW53_12190	COG0697	spore germination
EXW53_12195	COG1408	metallophosphoesterase
EXW53_12205	COG1131	(ABC) transporter
EXW53_12215	COG1309	transcriptional regulator
EXW53_12220	COG1960	acyl-CoA dehydrogenase activity
EXW53_12225	COG0439	Biotin carboxylase
EXW53_12230	COG0511	ligase activity, forming carbon-carbon bonds
EXW53_12235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW53_12240	COG1024	Enoyl-CoA hydratase
EXW53_12245	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW53_12250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW53_12305	COG2318	DinB family
EXW53_12310	COG1686	Belongs to the peptidase S11 family
EXW53_12345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW53_12375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW53_12400	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_12405	COG1733	regulation of RNA biosynthetic process
EXW53_12430	COG1309	transcriptional regulator
EXW53_12460	COG0697	spore germination
EXW53_12465	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_12495	COG2323	membrane
EXW53_12500	COG2132	Multicopper oxidase
EXW53_12515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_12520	COG0697	spore germination
EXW53_12525	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW53_12530	COG0201	protein transport
EXW53_12540	COG0737	Belongs to the 5'-nucleotidase family
EXW53_12545	COG3227	Zinc metalloprotease (Elastase)
EXW53_12550	COG1523	belongs to the glycosyl hydrolase 13 family
EXW53_12555	COG1073	alpha beta
EXW53_12565	COG0577	efflux transmembrane transporter activity
EXW53_12570	COG1136	(ABC) transporter
EXW53_12590	COG5002	protein histidine kinase activity
EXW53_12595	COG0745	RESPONSE REGULATOR receiver
EXW53_12600	COG1011	Hydrolase
EXW53_12625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW53_12630	COG1183	phosphatidylcholine synthase activity
EXW53_12635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW53_12650	COG1132	(ABC) transporter
EXW53_12660	COG3961	Belongs to the TPP enzyme family
EXW53_12680	COG0322	excinuclease ABC activity
EXW53_12705	COG2318	DinB family
EXW53_12720	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW53_12740	COG3878	Protein conserved in bacteria
EXW53_12750	COG0406	alpha-ribazole phosphatase activity
EXW53_12775	COG0592	DNA-directed DNA polymerase activity
EXW53_12790	COG2223	nitrite transmembrane transporter activity
EXW53_12800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW53_12810	COG0494	nUDIX hydrolase
EXW53_12840	COG0584	glycerophosphoryl diester phosphodiesterase
EXW53_12855	COG2814	Major facilitator Superfamily
EXW53_12905	COG0768	penicillin binding
EXW53_12910	COG0671	phosphoesterase, PA-phosphatase related
EXW53_12915	COG0604	alcohol dehydrogenase
EXW53_12920	COG5002	protein histidine kinase activity
EXW53_12925	COG0745	RESPONSE REGULATOR receiver
EXW53_12935	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW53_12945	COG2205	protein histidine kinase activity
EXW53_12965	COG4720	Psort location CytoplasmicMembrane, score
EXW53_12970	COG1794	racemase activity, acting on amino acids and derivatives
EXW53_12975	COG1819	glycosyl
EXW53_12985	COG0768	penicillin binding
EXW53_12990	COG5002	protein histidine kinase activity
EXW53_12995	COG0561	phosphatase activity
EXW53_13030	COG2124	cytochrome p450
EXW53_13060	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW53_13070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_13075	COG0460	homoserine dehydrogenase
EXW53_13095	COG0577	efflux transmembrane transporter activity
EXW53_13100	COG1136	(ABC) transporter
EXW53_13115	COG0488	(ABC) transporter
EXW53_13120	COG0667	Aldo Keto reductase
EXW53_13125	COG0583	DNA-binding transcription factor activity
EXW53_13130	COG2205	protein histidine kinase activity
EXW53_13135	COG0745	RESPONSE REGULATOR receiver
EXW53_13145	COG3773	Cell wall hydrolase
EXW53_13150	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW53_13190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_13205	COG2959	enzyme of heme biosynthesis
EXW53_13230	COG3483	tryptophan 2,3-dioxygenase activity
EXW53_13240	COG3844	kynureninase activity
EXW53_13245	COG1309	transcriptional regulator
EXW53_13280	COG1349	DNA-binding transcription factor activity
EXW53_13305	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_13310	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW53_13310	COG0456	acetyltransferase
EXW53_13345	COG4176	ABC-type proline glycine betaine transport system permease component
EXW53_13350	COG4175	Glycine betaine
EXW53_13350	COG0517	IMP dehydrogenase activity
EXW53_13375	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW53_13380	COG2153	protein acetylation
EXW53_13385	COG1132	(ABC) transporter
EXW53_13390	COG1819	glycosyl
EXW53_13410	COG2205	protein histidine kinase activity
EXW53_13415	COG2315	Protein conserved in bacteria
EXW53_13470	COG3973	AAA domain
EXW53_13475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW53_13495	COG0514	ATP-dependent DNA helicase (RecQ)
EXW53_13525	COG4637	Psort location Cytoplasmic, score
EXW53_13535	COG1227	inorganic diphosphatase activity
EXW53_13540	COG2318	DinB family
EXW53_13555	COG1162	GTPase activity
EXW53_13565	COG1115	amino acid carrier protein
EXW53_13570	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_13575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW53_13585	COG3938	Belongs to the proline racemase family
EXW53_13590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW53_13630	COG0586	Pfam SNARE associated Golgi protein
EXW53_13645	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW53_13650	COG4166	transmembrane transport
EXW53_13660	COG4948	Mandelate Racemase Muconate Lactonizing
EXW53_13675	COG0667	Aldo Keto reductase
EXW53_13720	COG2936	dipeptidyl-peptidase activity
EXW53_13725	COG5002	protein histidine kinase activity
EXW53_13730	COG0745	RESPONSE REGULATOR receiver
EXW53_13770	COG1164	Oligoendopeptidase f
EXW53_13795	COG1307	EDD domain protein, DegV family
EXW53_13835	COG2814	Major facilitator Superfamily
EXW53_13845	COG1664	Polymer-forming cytoskeletal
EXW53_13850	COG0789	Transcriptional regulator
EXW53_13855	COG4533	DNA binding
EXW53_13860	COG0477	Major facilitator Superfamily
EXW53_13860	COG2814	Major facilitator Superfamily
EXW53_13875	COG2261	transglycosylase associated protein
EXW53_13890	COG2226	methyltransferase
EXW53_13925	COG0436	Aminotransferase
EXW53_13930	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW53_13940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW53_13955	COG1131	(ABC) transporter
EXW53_13995	COG0628	permease
EXW53_14020	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW53_14035	COG0697	spore germination
EXW53_14080	COG2814	Major facilitator Superfamily
EXW53_14085	COG1368	sulfuric ester hydrolase activity
EXW53_14090	COG0488	(ABC) transporter
EXW53_14095	COG1033	growth of symbiont in host cell
EXW53_14095	COG2409	Drug exporters of the RND superfamily
EXW53_14100	COG1309	transcriptional regulator
EXW53_14115	COG0287	Prephenate dehydrogenase
EXW53_14130	COG1605	Chorismate mutase
EXW53_14130	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW53_14175	COG0346	lactoylglutathione lyase activity
EXW53_14185	COG0277	FAD linked oxidase domain protein
EXW53_14205	COG2610	gluconate transmembrane transporter activity
EXW53_14210	COG1024	Enoyl-CoA hydratase
EXW53_14220	COG3829	transcription factor binding
EXW53_14220	COG3290	protein histidine kinase activity
EXW53_14230	COG0579	oxidoreductase
EXW53_14235	COG1879	ABC-type sugar transport system periplasmic component
EXW53_14245	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW53_14250	COG1129	ABC transporter
EXW53_14255	COG2390	Transcriptional regulator
EXW53_14260	COG1070	Carbohydrate kinase
EXW53_14275	COG2226	methyltransferase
EXW53_14300	COG0346	lactoylglutathione lyase activity
EXW53_14305	COG2329	Antibiotic biosynthesis monooxygenase
EXW53_14325	COG1472	Belongs to the glycosyl hydrolase 3 family
EXW53_14330	COG2207	Transcriptional regulator
EXW53_14335	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_14340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW53_14345	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW53_14350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW53_14355	COG3239	Fatty acid desaturase
EXW53_14380	COG3842	ATPase activity
EXW53_14405	COG1175	transmembrane transport
EXW53_14410	COG1349	DNA-binding transcription factor activity
EXW53_14420	COG3655	Transcriptional regulator
EXW53_14435	COG4377	Putative membrane peptidase family (DUF2324)
EXW53_14445	COG3279	Response regulator of the LytR AlgR family
EXW53_14460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_14465	COG0346	lactoylglutathione lyase activity
EXW53_14495	COG0714	Associated with various cellular activities
EXW53_14515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW53_14520	COG0753	catalase activity
EXW53_14535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW53_14550	COG0714	Associated with various cellular activities
EXW53_14620	COG0778	Nitroreductase
EXW53_14625	COG1846	Transcriptional regulator
EXW53_14645	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW53_14655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW53_14660	COG0824	Thioesterase
EXW53_14665	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_14670	COG0183	Belongs to the thiolase family
EXW53_14675	COG1024	Enoyl-CoA hydratase
EXW53_14680	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW53_14685	COG2723	6-phospho-beta-galactosidase activity
EXW53_14690	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW53_14695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW53_14710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW53_14720	COG2508	Transcriptional regulator
EXW53_14725	COG2814	Major facilitator Superfamily
EXW53_14740	COG4884	unkown
EXW53_14740	COG3831	ATPase activity
EXW53_14760	COG2814	Major facilitator Superfamily
EXW53_14765	COG0577	efflux transmembrane transporter activity
EXW53_14765	COG1136	(ABC) transporter
EXW53_14780	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_14785	COG1309	transcriptional regulator
EXW53_14805	COG0456	acetyltransferase
EXW53_14820	COG0697	spore germination
EXW53_14825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_14845	COG0642	Histidine kinase
EXW53_14850	COG0745	RESPONSE REGULATOR receiver
EXW53_14855	COG0596	Alpha beta hydrolase
EXW53_14885	COG0730	response to heat
EXW53_14895	COG0833	amino acid
EXW53_14905	COG4335	DNA alkylation repair
EXW53_14930	COG0768	penicillin binding
EXW53_14940	COG3104	oligopeptide transport
EXW53_14950	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW53_14965	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW53_14970	COG1984	allophanate hydrolase subunit 2
EXW53_14975	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW53_14980	COG1414	Transcriptional regulator
EXW53_14995	COG1960	acyl-CoA dehydrogenase activity
EXW53_15030	COG0640	Transcriptional regulator
EXW53_15035	COG3314	Sporulation integral membrane protein YlbJ
EXW53_15055	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW53_15085	COG0574	Belongs to the PEP-utilizing enzyme family
EXW53_15085	COG3848	Pyruvate phosphate dikinase
EXW53_15130	COG0798	PFAM Bile acid sodium symporter
EXW53_15135	COG0346	lactoylglutathione lyase activity
EXW53_15140	COG0640	Transcriptional regulator
EXW53_15155	COG1309	transcriptional regulator
EXW53_15160	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_15165	COG1522	sequence-specific DNA binding
EXW53_15200	COG0346	lactoylglutathione lyase activity
EXW53_15215	COG0457	Tetratricopeptide repeat
EXW53_15230	COG0745	RESPONSE REGULATOR receiver
EXW53_15235	COG3850	Histidine kinase
EXW53_15235	COG5002	protein histidine kinase activity
EXW53_15270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW53_15275	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW53_15285	COG2309	aminopeptidase activity
EXW53_15290	COG2226	methyltransferase
EXW53_15305	COG1690	Belongs to the RtcB family
EXW53_15330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW53_15345	COG1136	(ABC) transporter
EXW53_15350	COG0577	efflux transmembrane transporter activity
EXW53_15365	COG5002	protein histidine kinase activity
EXW53_15365	COG3850	Histidine kinase
EXW53_15380	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_15400	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW53_15415	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW53_15435	COG1595	DNA-templated transcription, initiation
EXW53_15480	COG2814	Major facilitator Superfamily
EXW53_15575	COG2849	repeat protein
EXW53_15725	COG1876	peptidase activity
EXW53_15730	COG2843	Capsule synthesis protein
EXW53_15745	COG0477	Major facilitator Superfamily
EXW53_15760	COG1846	Transcriptional regulator
EXW53_15765	COG2814	Major facilitator Superfamily
EXW53_15780	COG0076	glutamate decarboxylase activity
EXW53_15795	COG0561	phosphatase activity
EXW53_15865	COG1696	Membrane protein involved in D-alanine export
EXW53_15885	COG1595	DNA-templated transcription, initiation
EXW53_15915	COG1329	Transcriptional regulator
EXW53_16115	COG4187	Peptidase family M20/M25/M40
EXW53_16120	COG1414	Transcriptional regulator
EXW53_16125	COG0833	amino acid
EXW53_16140	COG2031	fatty acid transporter
EXW53_16150	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW53_16200	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW53_16205	COG2356	endonuclease I
EXW53_16210	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW53_16215	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW53_16225	COG2197	response regulator
EXW53_16240	COG0469	pyruvate kinase activity
EXW53_16245	COG1785	Belongs to the alkaline phosphatase family
EXW53_16260	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_16270	COG1131	(ABC) transporter
EXW53_16290	COG0494	nUDIX hydrolase
EXW53_16300	COG1011	Hydrolase
EXW53_16305	COG2365	Tyrosine phosphatase family
EXW53_16335	COG0628	permease
EXW53_16355	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW53_16360	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW53_16370	COG1253	flavin adenine dinucleotide binding
EXW53_16375	COG0789	Transcriptional regulator
EXW53_16380	COG0697	spore germination
EXW53_16390	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW53_16395	COG3813	Protein conserved in bacteria
EXW53_16400	COG4702	Belongs to the UPF0303 family
EXW53_16410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_16415	COG0494	nUDIX hydrolase
EXW53_16420	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW53_16430	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_16440	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW53_16445	COG1733	regulation of RNA biosynthetic process
EXW53_16460	COG1191	sigma factor activity
EXW53_16485	COG0814	amino acid
EXW53_16505	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_16510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW53_16515	COG3800	Transcriptional regulator
EXW53_16515	COG1396	sequence-specific DNA binding
EXW53_16540	COG1151	hydroxylamine reductase activity
EXW53_16570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW53_16580	COG2072	flavoprotein involved in K transport
EXW53_16630	COG1695	Transcriptional regulator
EXW53_16635	COG0604	alcohol dehydrogenase
EXW53_16640	COG1113	amino acid transport
EXW53_16665	COG0745	RESPONSE REGULATOR receiver
EXW53_16670	COG5002	protein histidine kinase activity
EXW53_16680	COG2814	Major facilitator Superfamily
EXW53_16690	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW53_16695	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_16705	COG0534	Mate efflux family protein
EXW53_16710	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_16715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW53_16730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW53_16735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW53_16755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW53_16760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_16765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_16770	COG3739	integral membrane protein
EXW53_16790	COG0583	DNA-binding transcription factor activity
EXW53_16815	COG1193	negative regulation of DNA recombination
EXW53_16825	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW53_16830	COG1164	Oligoendopeptidase f
EXW53_16855	COG3781	membrane
EXW53_16870	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW53_16885	COG0640	Transcriptional regulator
EXW53_16890	COG0604	alcohol dehydrogenase
EXW53_16895	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW53_16900	COG0457	Tetratricopeptide repeat
EXW53_16910	COG2808	Putative FMN-binding domain
EXW53_16915	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW53_16925	COG0277	FAD linked oxidase domain protein
EXW53_16955	COG2514	catechol 2,3-dioxygenase activity
EXW53_16960	COG2720	vancomycin resistance protein
EXW53_16985	COG1278	Cold shock
EXW53_16995	COG0716	FMN binding
EXW53_17025	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_17035	COG0165	Argininosuccinate lyase
EXW53_17050	COG4145	pantothenate transmembrane transporter activity
EXW53_17060	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_17065	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_17075	COG1657	PFAM Prenyltransferase squalene oxidase
EXW53_17080	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW53_17085	COG2962	Rard protein
EXW53_17090	COG3326	Membrane
EXW53_17095	COG0531	amino acid
EXW53_17125	COG2226	methyltransferase
EXW53_17130	COG4166	transmembrane transport
EXW53_17135	COG4166	transmembrane transport
EXW53_17140	COG4166	transmembrane transport
EXW53_17150	COG1131	(ABC) transporter
EXW53_17160	COG0673	inositol 2-dehydrogenase activity
EXW53_17165	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW53_17170	COG0187	DNA topoisomerase II activity
EXW53_17175	COG1832	CoA-binding protein
EXW53_17180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW53_17185	COG0745	RESPONSE REGULATOR receiver
EXW53_17195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW53_17195	COG1328	CTP reductase activity
EXW53_17205	COG4841	protein insertion into membrane
EXW53_17210	COG0824	Thioesterase
EXW53_17235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW53_17255	COG1266	CAAX protease self-immunity
EXW53_17260	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW53_17290	COG2211	Major facilitator Superfamily
EXW53_17300	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW53_17315	COG0183	Belongs to the thiolase family
EXW53_17320	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_17325	COG1268	BioY protein
EXW53_17330	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_17370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_17380	COG5002	protein histidine kinase activity
EXW53_17390	COG0400	carboxylic ester hydrolase activity
EXW53_17400	COG0069	glutamate synthase activity
EXW53_17405	COG1902	pentaerythritol trinitrate reductase activity
EXW53_17410	COG1329	Transcriptional regulator
EXW53_17415	COG0010	Belongs to the arginase family
EXW53_17425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW53_17430	COG2986	histidine ammonia-lyase
EXW53_17440	COG2226	methyltransferase
EXW53_17465	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW53_17470	COG0785	Cytochrome C biogenesis protein
EXW53_17480	COG1473	amidohydrolase
EXW53_17490	COG1131	(ABC) transporter
EXW53_17505	COG0583	DNA-binding transcription factor activity
EXW53_17515	COG1346	cytolysis
EXW53_17550	COG1132	(ABC) transporter
EXW53_17555	COG1132	(ABC) transporter
EXW53_17560	COG3763	UPF0154 protein
EXW53_17575	COG3639	organic phosphonate transmembrane transporter activity
EXW53_17580	COG3639	organic phosphonate transmembrane transporter activity
EXW53_17590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW53_17595	COG0737	Belongs to the 5'-nucleotidase family
EXW53_17605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW53_17610	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW53_17625	COG1695	Transcriptional regulator
EXW53_17630	COG1132	(ABC) transporter
EXW53_17665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW53_17670	COG0110	maltose O-acetyltransferase activity
EXW53_17675	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW53_17685	COG3420	alginic acid biosynthetic process
EXW53_17685	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW53_17690	COG1216	Glycosyl transferase, family 2
EXW53_17690	COG1442	glycosyl transferase family 8
EXW53_17695	COG0438	transferase activity, transferring glycosyl groups
EXW53_17725	COG1216	Glycosyl transferase, family 2
EXW53_17745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW53_17745	COG0463	Glycosyl transferase, family 2
EXW53_17750	COG0438	transferase activity, transferring glycosyl groups
EXW53_17755	COG0438	transferase activity, transferring glycosyl groups
EXW53_17760	COG1086	Polysaccharide biosynthesis protein
EXW53_17765	COG0489	protein tyrosine kinase activity
EXW53_17770	COG3944	biosynthesis protein
EXW53_17775	COG0174	glutamine synthetase
EXW53_17780	COG0789	Transcriptional regulator
EXW53_17785	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW53_17790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW53_17795	COG2860	membrane
EXW53_17805	COG0464	growth
EXW53_17825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW53_17835	COG1388	LysM domain
EXW53_17835	COG3584	3D domain protein
EXW53_17840	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW53_17840	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW53_17840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW53_17845	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW53_17850	COG1349	DNA-binding transcription factor activity
EXW53_17855	COG1979	alcohol dehydrogenase
EXW53_17860	COG2322	membrane
EXW53_17870	COG1473	amidohydrolase
EXW53_17875	COG1408	metallophosphoesterase
EXW53_17890	COG2217	Heavy metal translocating P-type atpase
EXW53_17895	COG2608	mercury ion transmembrane transporter activity
EXW53_17900	COG1937	Protein conserved in bacteria
EXW53_17930	COG2819	hydrolase of the alpha beta superfamily
EXW53_17935	COG1120	ATPase activity
EXW53_17940	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_17945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_17950	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW53_17955	COG0708	Exodeoxyribonuclease III
EXW53_17960	COG2169	Transcriptional regulator
EXW53_17965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW53_17970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW53_17975	COG2706	6-phosphogluconolactonase activity
EXW53_17980	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW53_17995	COG0346	lactoylglutathione lyase activity
EXW53_18000	COG3300	MHYT domain
EXW53_18000	COG5001	Diguanylate cyclase
EXW53_18035	COG1346	cytolysis
EXW53_18045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_18050	COG0596	Alpha beta hydrolase
EXW53_18050	COG2945	thiolester hydrolase activity
EXW53_18055	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW53_18065	COG2188	Transcriptional regulator
EXW53_18070	COG2723	6-phospho-beta-galactosidase activity
EXW53_18080	COG3773	Cell wall hydrolase
EXW53_18090	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW53_18115	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW53_18120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW53_18125	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW53_18130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW53_18130	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW53_18140	COG2359	stage V sporulation protein S
EXW53_18145	COG1692	metallophosphoesterase
EXW53_18150	COG1418	mRNA catabolic process
EXW53_18155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW53_18170	COG1546	Belongs to the CinA family
EXW53_18170	COG1058	Belongs to the CinA family
EXW53_18175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW53_18180	COG1426	Protein conserved in bacteria
EXW53_18195	COG0300	oxidoreductase activity
EXW53_18200	COG0612	Peptidase, M16
EXW53_18205	COG0612	Peptidase, M16
EXW53_18210	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW53_18215	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW53_18220	COG3845	ABC transporter
EXW53_18225	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW53_18230	COG2188	Transcriptional regulator
EXW53_18240	COG1674	ftsk spoiiie
EXW53_18250	COG0740	serine-type endopeptidase activity
EXW53_18255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW53_18265	COG0527	aspartate kinase activity
EXW53_18270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW53_18275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW53_18280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW53_18285	COG1873	PFAM PRC-barrel domain
EXW53_18290	COG0612	Peptidase, M16
EXW53_18295	COG0726	polysaccharide deacetylase
EXW53_18300	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW53_18310	COG0196	riboflavin kinase activity
EXW53_18320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW53_18325	COG1550	Protein conserved in bacteria
EXW53_18330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW53_18335	COG1358	cellular component organization or biogenesis
EXW53_18340	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW53_18345	COG0195	Participates in both transcription termination and antitermination
EXW53_18360	COG0442	prolyl-tRNA aminoacylation
EXW53_18365	COG0750	zinc metalloprotease
EXW53_18375	COG4589	Belongs to the CDS family
EXW53_18385	COG0233	cytoplasmic translational termination
EXW53_18390	COG0528	UMP kinase activity
EXW53_18395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW53_18405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW53_18410	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW53_18415	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW53_18420	COG4974	Belongs to the 'phage' integrase family
EXW53_18425	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW53_18430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW53_18435	COG0758	DNA mediated transformation
EXW53_18440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW53_18445	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW53_18450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW53_18465	COG0335	large ribosomal subunit rRNA binding
EXW53_18470	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW53_18475	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW53_18480	COG1837	Belongs to the UPF0109 family
EXW53_18490	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW53_18500	COG0552	protein localization to endoplasmic reticulum
EXW53_18505	COG1196	nuclear chromosome segregation
EXW53_18510	COG0571	ribonuclease III activity
EXW53_18515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW53_18520	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_18525	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW53_18530	COG0416	fatty acid biosynthetic process
EXW53_18540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW53_18545	COG1461	Dihydroxyacetone kinase
EXW53_18550	COG1302	Protein conserved in bacteria
EXW53_18565	COG1564	THIamine pyrophosphokinase
EXW53_18570	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW53_18580	COG2815	serine threonine protein kinase
EXW53_18580	COG0515	serine threonine protein kinase
EXW53_18585	COG0631	protein serine/threonine phosphatase activity
EXW53_18590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW53_18595	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW53_18595	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW53_18600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW53_18605	COG0242	peptide deformylase activity
EXW53_18610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW53_18615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW53_18620	COG1758	RNA polymerase activity
EXW53_18635	COG1561	YicC-like family, N-terminal region
EXW53_18640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW53_18655	COG0006	proline dipeptidase activity
EXW53_18675	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW53_18700	COG0167	dihydroorotate dehydrogenase activity
EXW53_18705	COG0543	2 iron, 2 sulfur cluster binding
EXW53_18710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW53_18720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW53_18725	COG0540	Belongs to the ATCase OTCase family
EXW53_18735	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW53_18740	COG0564	pseudouridine synthase activity
EXW53_18760	COG3599	regulation of cell shape
EXW53_18765	COG2302	S4 RNA-binding domain
EXW53_18770	COG0762	integral membrane protein
EXW53_18775	COG1799	cell septum assembly
EXW53_18780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW53_18790	COG1873	PFAM PRC-barrel domain
EXW53_18795	COG1191	sigma factor activity
EXW53_18800	COG1191	sigma factor activity
EXW53_18810	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW53_18815	COG0849	cell division
EXW53_18820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW53_18835	COG0772	Belongs to the SEDS family
EXW53_18840	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW53_18845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW53_18850	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW53_18855	COG0768	penicillin binding
EXW53_18860	COG0768	penicillin binding
EXW53_18870	COG0275	rRNA processing
EXW53_18875	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW53_18880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW53_18885	COG0454	-acetyltransferase
EXW53_18895	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW53_18900	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW53_18905	COG1323	Belongs to the UPF0348 family
EXW53_18910	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW53_18915	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW53_18920	COG3314	Sporulation integral membrane protein YlbJ
EXW53_18930	COG0742	ribosomal rna small subunit methyltransferase
EXW53_18940	COG4471	UPF0298 protein
EXW53_18945	COG3679	Belongs to the UPF0342 family
EXW53_18950	COG0406	alpha-ribazole phosphatase activity
EXW53_18965	COG2340	Cysteine-rich secretory protein family
EXW53_18975	COG3336	cytochrome c oxidase
EXW53_19000	COG0109	protoheme IX farnesyltransferase activity
EXW53_19005	COG1612	heme a metabolic process
EXW53_19010	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW53_19015	COG0772	Belongs to the SEDS family
EXW53_19020	COG4838	Belongs to the UPF0358 family
EXW53_19025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW53_19030	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW53_19040	COG4896	Protein conserved in bacteria
EXW53_19055	COG1217	gtp-binding protein TYPA
EXW53_19065	COG0483	inositol monophosphate 1-phosphatase activity
EXW53_19075	COG4493	Belongs to the UPF0637 family
EXW53_19080	COG4476	Belongs to the UPF0223 family
EXW53_19085	COG1982	Orn Lys Arg decarboxylase major
EXW53_19140	COG0022	dehydrogenase e1 component
EXW53_19145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW53_19160	COG0561	phosphatase activity
EXW53_19165	COG5503	Protein of unknown function (DUF1447)
EXW53_19170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW53_19175	COG0569	domain protein
EXW53_19185	COG1473	amidohydrolase
EXW53_19190	COG2171	N-acyltransferase activity
EXW53_19195	COG0583	DNA-binding transcription factor activity
EXW53_19200	COG0517	IMP dehydrogenase activity
EXW53_19210	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW53_19220	COG4703	Protein of unknown function (DUF1797)
EXW53_19235	COG2200	EAL domain
EXW53_19240	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_19245	COG1408	metallophosphoesterase
EXW53_19290	COG2814	Major facilitator Superfamily
EXW53_19300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW53_19310	COG3209	COG3209 Rhs family protein
EXW53_19320	COG2205	protein histidine kinase activity
EXW53_19330	COG0436	Aminotransferase
EXW53_19335	COG1609	Transcriptional regulator
EXW53_19340	COG3833	ABC-type maltose transport systems, permease component
EXW53_19345	COG1175	transmembrane transport
EXW53_19350	COG2182	Extracellular solute-binding protein
EXW53_19360	COG0366	Alpha amylase catalytic
EXW53_19365	COG3842	ATPase activity
EXW53_19410	COG0183	Belongs to the thiolase family
EXW53_19445	COG1695	Transcriptional regulator
EXW53_19450	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_19460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW53_19465	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW53_19470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW53_19475	COG0436	Aminotransferase
EXW53_19480	COG1850	ribulose-bisphosphate carboxylase activity
EXW53_19485	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW53_19490	COG0235	Class ii aldolase
EXW53_19495	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW53_19510	COG2084	Dehydrogenase
EXW53_19520	COG2199	diguanylate cyclase activity
EXW53_19525	COG0778	Nitroreductase
EXW53_19550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW53_19550	COG2190	(PTS) system
EXW53_19550	COG1263	PTS System
EXW53_19555	COG3711	transcriptional antiterminator
EXW53_19565	COG2188	Transcriptional regulator
EXW53_19570	COG0363	glucosamine-6-phosphate deaminase activity
EXW53_19575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW53_19585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW53_19590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW53_19600	COG1547	Domain of unknown function (DUF309)
EXW53_19610	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW53_19615	COG4086	secreted protein
EXW53_19620	COG0561	phosphatase activity
EXW53_19625	COG0697	spore germination
EXW53_19640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW53_19680	COG1686	Belongs to the peptidase S11 family
EXW53_19685	COG1725	Transcriptional regulator
EXW53_19690	COG1131	(ABC) transporter
EXW53_19715	COG1846	Transcriptional regulator
EXW53_19730	COG0598	Magnesium transport protein CorA
EXW53_19745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW53_19755	COG4974	Belongs to the 'phage' integrase family
EXW53_19765	COG0735	belongs to the Fur family
EXW53_19770	COG1300	Membrane
EXW53_19790	COG0667	Aldo Keto reductase
EXW53_19795	COG0656	L-ascorbic acid biosynthetic process
EXW53_19800	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW53_19800	COG0456	acetyltransferase
EXW53_19810	COG0737	Belongs to the 5'-nucleotidase family
EXW53_19810	COG1525	nuclease
EXW53_19810	COG4085	toxin activity
EXW53_19815	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW53_19825	COG0596	Alpha beta hydrolase
EXW53_19830	COG2056	Na+-H+ antiporter family
EXW53_19835	COG1609	Transcriptional regulator
EXW53_19840	COG0456	acetyltransferase
EXW53_19845	COG1073	alpha beta
EXW53_19860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW53_19860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW53_19865	COG0307	riboflavin synthase, alpha
EXW53_19870	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW53_19870	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW53_19885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW53_19895	COG2226	methyltransferase
EXW53_19895	COG1073	alpha beta
EXW53_19900	COG0156	8-amino-7-oxononanoate synthase activity
EXW53_19910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW53_19920	COG1757	Na H antiporter
EXW53_19925	COG0737	Belongs to the 5'-nucleotidase family
EXW53_19935	COG1522	sequence-specific DNA binding
EXW53_19955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW53_19960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXW53_19970	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW53_19980	COG0300	oxidoreductase activity
EXW53_19985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_19990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW53_19995	COG1760	l-serine dehydratase
EXW53_20000	COG1760	l-serine dehydratase
EXW53_20010	COG1234	tRNA 3'-trailer cleavage
EXW53_20025	COG1285	pathogenesis
EXW53_20040	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW53_20045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_20060	COG1376	ErfK ybiS ycfS ynhG family protein
EXW53_20065	COG4129	membrane
EXW53_20070	COG1126	abc transporter atp-binding protein
EXW53_20075	COG0765	amino acid transport
EXW53_20080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW53_20095	COG2816	NAD+ diphosphatase activity
EXW53_20100	COG2323	membrane
EXW53_20105	COG0772	Belongs to the SEDS family
EXW53_20110	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW53_20115	COG0022	dehydrogenase e1 component
EXW53_20120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW53_20125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW53_20130	COG3426	butyrate kinase activity
EXW53_20140	COG0280	phosphate acetyltransferase
EXW53_20145	COG3290	protein histidine kinase activity
EXW53_20145	COG3829	transcription factor binding
EXW53_20155	COG0584	glycerophosphoryl diester phosphodiesterase
EXW53_20160	COG3093	addiction module antidote protein HigA
EXW53_20170	COG0745	RESPONSE REGULATOR receiver
EXW53_20175	COG0750	zinc metalloprotease
EXW53_20180	COG0497	DNA recombination
EXW53_20185	COG1438	arginine binding
EXW53_20190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW53_20195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW53_20200	COG0142	geranyltranstransferase activity
EXW53_20205	COG1722	exodeoxyribonuclease VII activity
EXW53_20215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW53_20220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW53_20225	COG1302	Protein conserved in bacteria
EXW53_20230	COG0439	Biotin carboxylase
EXW53_20235	COG0511	ligase activity, forming carbon-carbon bonds
EXW53_20280	COG3854	ATPases associated with a variety of cellular activities
EXW53_20300	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW53_20305	COG0006	proline dipeptidase activity
EXW53_20320	COG3872	metal-dependent enzyme
EXW53_20330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW53_20365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW53_20375	COG1609	Transcriptional regulator
EXW53_20385	COG2076	Multidrug Resistance protein
EXW53_20390	COG2076	Multidrug Resistance protein
EXW53_20425	COG1725	Transcriptional regulator
EXW53_20440	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW53_20445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW53_20450	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW53_20455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW53_20485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW53_20510	COG4970	Tfp pilus assembly protein FimT
EXW53_20515	COG4537	Required for transformation and DNA binding
EXW53_20520	COG1459	type II secretion system
EXW53_20525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW53_20580	COG1410	methionine synthase
EXW53_20580	COG0646	methionine synthase
EXW53_20585	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW53_20585	COG0646	methionine synthase
EXW53_20590	COG0626	cystathionine gamma-synthase activity
EXW53_20595	COG0626	cystathionine gamma-synthase activity
EXW53_20615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_20625	COG1940	carbohydrate kinase activity
EXW53_20630	COG4483	Protein conserved in bacteria
EXW53_20635	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW53_20640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW53_20645	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW53_20650	COG0704	Plays a role in the regulation of phosphate uptake
EXW53_20660	COG0581	inorganic phosphate transmembrane transporter activity
EXW53_20665	COG0573	inorganic phosphate transmembrane transporter activity
EXW53_20670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW53_20675	COG0768	penicillin binding
EXW53_20680	COG0477	Major facilitator Superfamily
EXW53_20685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW53_20705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW53_20710	COG0735	belongs to the Fur family
EXW53_20715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW53_20720	COG1121	(ABC) transporter
EXW53_20725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_20735	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW53_20755	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW53_20760	COG2384	SAM-dependent methyltransferase
EXW53_20765	COG2010	Cytochrome c
EXW53_20770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW53_20775	COG0358	DNA primase activity
EXW53_20785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW53_20790	COG0517	IMP dehydrogenase activity
EXW53_20795	COG1381	Involved in DNA repair and RecF pathway recombination
EXW53_20805	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW53_20810	COG0295	cytidine deaminase activity
EXW53_20815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW53_20820	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW53_20825	COG1480	7TM receptor with intracellular HD hydrolase
EXW53_20830	COG1702	phosphate starvation-inducible protein PhoH
EXW53_20845	COG1610	YqeY-like protein
EXW53_20850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW53_20860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW53_20865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW53_20875	COG0484	heat shock protein binding
EXW53_20880	COG0443	Heat shock 70 kDa protein
EXW53_20890	COG1420	regulation of RNA biosynthetic process
EXW53_20895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW53_20900	COG1733	regulation of RNA biosynthetic process
EXW53_20905	COG0481	GTPase activity
EXW53_20915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW53_20920	COG0268	Binds directly to 16S ribosomal RNA
EXW53_20925	COG1466	dna polymerase III delta subunit
EXW53_20935	COG0658	competence protein
EXW53_20935	COG2333	competence protein COMEC
EXW53_20940	COG2131	deaminase
EXW53_20945	COG1555	photosystem II stabilization
EXW53_20945	COG1596	polysaccharide export
EXW53_20950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW53_20955	COG2226	methyltransferase
EXW53_20960	COG0799	negative regulation of ribosome biogenesis
EXW53_20965	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW53_20970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW53_20975	COG1534	Rna-binding protein
EXW53_20980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW53_20985	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW53_20990	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW53_21000	COG0688	phosphatidylethanolamine metabolic process
EXW53_21020	COG2357	RelA SpoT domain protein
EXW53_21030	COG1785	Belongs to the alkaline phosphatase family
EXW53_21040	COG2267	carboxylic ester hydrolase activity
EXW53_21075	COG1404	Belongs to the peptidase S8 family
EXW53_21080	COG3186	Phenylalanine-4-hydroxylase
EXW53_21090	COG2514	catechol 2,3-dioxygenase activity
EXW53_21095	COG2259	Doxx family
EXW53_21135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW53_21145	COG1454	alcohol dehydrogenase
EXW53_21145	COG1012	belongs to the aldehyde dehydrogenase family
EXW53_21155	COG0626	cystathionine gamma-synthase activity
EXW53_21160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW53_21165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW53_21170	COG2226	methyltransferase
EXW53_21185	COG0768	penicillin binding
EXW53_21190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW53_21195	COG0572	uridine kinase
EXW53_21200	COG0826	peptidase U32
EXW53_21205	COG0826	peptidase U32
EXW53_21210	COG4122	O-methyltransferase activity
EXW53_21215	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW53_21225	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW53_21240	COG0628	permease
EXW53_21260	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW53_21270	COG0482	sulfurtransferase activity
EXW53_21275	COG1104	cysteine desulfurase activity
EXW53_21280	COG1959	2 iron, 2 sulfur cluster binding
EXW53_21285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW53_21295	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW53_21300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW53_21320	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW53_21325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW53_21330	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW53_21330	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW53_21335	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW53_21340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW53_21340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW53_21350	COG2244	polysaccharide biosynthetic process
EXW53_21355	COG2323	membrane
EXW53_21365	COG1862	Preprotein translocase
EXW53_21370	COG0343	queuine tRNA-ribosyltransferase activity
EXW53_21375	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW53_21385	COG2255	four-way junction helicase activity
EXW53_21390	COG0632	four-way junction helicase activity
EXW53_21395	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW53_21420	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW53_21425	COG0157	Belongs to the NadC ModD family
EXW53_21430	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW53_21435	COG1104	cysteine desulfurase activity
EXW53_21440	COG1827	regulation of RNA biosynthetic process
EXW53_21445	COG2258	MOSC domain
EXW53_21450	COG0077	Prephenate dehydratase
EXW53_21455	COG0577	efflux transmembrane transporter activity
EXW53_21460	COG0577	efflux transmembrane transporter activity
EXW53_21465	COG1136	(ABC) transporter
EXW53_21470	COG5002	protein histidine kinase activity
EXW53_21475	COG0745	RESPONSE REGULATOR receiver
EXW53_21480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW53_21485	COG3290	protein histidine kinase activity
EXW53_21495	COG2868	ribosomal protein
EXW53_21505	COG1530	ribonuclease E activity
EXW53_21510	COG1994	Peptidase M50
EXW53_21515	COG0739	heme binding
EXW53_21520	COG2894	cell division
EXW53_21525	COG0850	regulation of cytokinetic process
EXW53_21540	COG1077	Cell shape determining protein MreB Mrl
EXW53_21545	COG2003	Belongs to the UPF0758 family
EXW53_21550	COG0424	maF-like protein
EXW53_21560	COG0285	dihydrofolate synthase activity
EXW53_21575	COG1388	LysM domain
EXW53_21580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW53_21585	COG0113	porphobilinogen synthase activity
EXW53_21590	COG1587	Uroporphyrinogen-III synthase
EXW53_21595	COG0181	hydroxymethylbilane synthase activity
EXW53_21600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW53_21605	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW53_21610	COG1846	Transcriptional regulator
EXW53_21615	COG1764	response to oxidative stress
EXW53_21620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW53_21630	COG1067	ATP-dependent peptidase activity
EXW53_21630	COG0470	DNA polymerase III
EXW53_21640	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW53_21675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW53_21690	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW53_21720	COG0622	Phosphoesterase
EXW53_21730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW53_21735	COG5401	PFAM Sporulation and spore germination
EXW53_21745	COG2197	response regulator
EXW53_21750	COG2233	PERMEase
EXW53_21755	COG0402	S-adenosylhomocysteine deaminase activity
EXW53_21760	COG1983	PspC domain protein
EXW53_21765	COG1396	sequence-specific DNA binding
EXW53_21770	COG0697	spore germination
EXW53_21780	COG1959	2 iron, 2 sulfur cluster binding
EXW53_21785	COG1668	transmembrane transport
EXW53_21790	COG4152	abc transporter atp-binding protein
EXW53_21795	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW53_21800	COG1360	Flagellar Motor Protein
EXW53_21805	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW53_21810	COG1876	peptidase activity
EXW53_21815	COG0824	Thioesterase
EXW53_21820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW53_21825	COG1053	succinate dehydrogenase
EXW53_21830	COG2009	succinate dehydrogenase
EXW53_21835	COG1719	4-vinyl reductase, 4VR
EXW53_21840	COG0322	excinuclease ABC activity
EXW53_21845	COG3118	belongs to the thioredoxin family
EXW53_21850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW53_21855	COG2086	electron transfer activity
EXW53_21860	COG1024	Enoyl-CoA hydratase
EXW53_21865	COG1309	transcriptional regulator
EXW53_21870	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_21910	COG1131	(ABC) transporter
EXW53_21915	COG2205	protein histidine kinase activity
EXW53_21920	COG0745	RESPONSE REGULATOR receiver
EXW53_21930	COG4895	conserved protein (DUF2196)
EXW53_21935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW53_21945	COG4509	Sortase family
EXW53_21950	COG1120	ATPase activity
EXW53_21965	COG5386	Cell surface protein
EXW53_21975	COG5386	Cell surface protein
EXW53_21980	COG1114	Component of the transport system for branched-chain amino acids
EXW53_21985	COG1187	pseudouridine synthase activity
EXW53_21990	COG1193	negative regulation of DNA recombination
EXW53_21995	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW53_21995	COG1796	DNA polymerase
EXW53_22000	COG1286	toxin biosynthetic process
EXW53_22005	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW53_22010	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW53_22035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW53_22040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW53_22050	COG1418	mRNA catabolic process
EXW53_22070	COG2814	Major facilitator Superfamily
EXW53_22075	COG1566	PFAM secretion protein HlyD family protein
EXW53_22080	COG1309	transcriptional regulator
EXW53_22085	COG1363	Peptidase, m42
EXW53_22095	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW53_22110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW53_22120	COG1484	DNA-dependent DNA replication
EXW53_22125	COG3611	Membrane attachment protein
EXW53_22130	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW53_22135	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW53_22140	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW53_22145	COG0237	dephospho-CoA kinase activity
EXW53_22150	COG1971	Probably functions as a manganese efflux pump
EXW53_22160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW53_22160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW53_22165	COG5002	protein histidine kinase activity
EXW53_22170	COG0745	RESPONSE REGULATOR receiver
EXW53_22190	COG0538	isocitrate dehydrogenase activity
EXW53_22195	COG0372	Belongs to the citrate synthase family
EXW53_22205	COG0628	permease
EXW53_22210	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW53_22220	COG0205	6-phosphofructokinase activity
EXW53_22235	COG1725	Transcriptional regulator
EXW53_22240	COG0281	malic enzyme
EXW53_22245	COG0587	DNA-directed DNA polymerase activity
EXW53_22260	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW53_22275	COG4109	DRTGG domain
EXW53_22285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW53_22290	COG0006	proline dipeptidase activity
EXW53_22325	COG0662	Cupin 2, conserved barrel domain protein
EXW53_22335	COG1476	TRANSCRIPTIONal
EXW53_22350	COG1028	Short-chain dehydrogenase reductase Sdr
EXW53_22355	COG0589	response to stress
EXW53_22375	COG0165	Argininosuccinate lyase
EXW53_22380	COG0137	argininosuccinate synthase activity
EXW53_22395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_22415	COG0827	DNA restriction-modification system
EXW53_22420	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW53_22425	COG3874	Sporulation protein YtfJ
EXW53_22440	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW53_22450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW53_22465	COG1104	cysteine desulfurase activity
EXW53_22470	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW53_22475	COG0583	DNA-binding transcription factor activity
EXW53_22480	COG0697	spore germination
EXW53_22485	COG1309	transcriptional regulator
EXW53_22490	COG1956	GAF domain-containing protein
EXW53_22495	COG0626	cystathionine gamma-synthase activity
EXW53_22500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW53_22510	COG5444	nuclease activity
EXW53_22545	COG1595	DNA-templated transcription, initiation
EXW53_22555	COG0110	maltose O-acetyltransferase activity
EXW53_22560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW53_22565	COG0454	-acetyltransferase
EXW53_22570	COG0517	IMP dehydrogenase activity
EXW53_22575	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW53_22590	COG0745	RESPONSE REGULATOR receiver
EXW53_22595	COG5002	protein histidine kinase activity
EXW53_22600	COG0666	response to abiotic stimulus
EXW53_22630	COG1609	Transcriptional regulator
EXW53_22635	COG4851	CamS sex pheromone cAM373 precursor
EXW53_22640	COG3118	belongs to the thioredoxin family
EXW53_22650	COG2309	aminopeptidase activity
EXW53_22675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW53_22685	COG1674	ftsk spoiiie
EXW53_22700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW53_22705	COG4848	Belongs to the UPF0354 family
EXW53_22710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW53_22715	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW53_22720	COG1363	Peptidase, m42
EXW53_22730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_22735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW53_22745	COG0510	thiamine kinase activity
EXW53_22750	COG1523	belongs to the glycosyl hydrolase 13 family
EXW53_22760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW53_22765	COG1349	DNA-binding transcription factor activity
EXW53_22770	COG1187	pseudouridine synthase activity
EXW53_22775	COG2244	polysaccharide biosynthetic process
EXW53_22780	COG2081	HI0933 family
EXW53_22785	COG2814	Major facilitator Superfamily
EXW53_22795	COG3832	glyoxalase III activity
EXW53_22815	COG1329	Transcriptional regulator
EXW53_22830	COG0314	molybdopterin synthase activity
EXW53_22835	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW53_22840	COG0303	'Molybdopterin
EXW53_22845	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW53_22850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW53_22855	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW53_22875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW53_22885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW53_22920	COG0495	leucyl-tRNA aminoacylation
EXW53_22925	COG2814	Major facilitator Superfamily
EXW53_22930	COG0475	glutathione-regulated potassium exporter activity
EXW53_22935	COG0490	domain, Protein
EXW53_22940	COG0582	viral genome integration into host DNA
EXW53_22955	COG1136	(ABC) transporter
EXW53_22970	COG1242	4 iron, 4 sulfur cluster binding
EXW53_22975	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW53_22980	COG1794	racemase activity, acting on amino acids and derivatives
EXW53_23000	COG2267	carboxylic ester hydrolase activity
EXW53_23005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW53_23010	COG0671	phosphoesterase, PA-phosphatase related
EXW53_23015	COG0438	transferase activity, transferring glycosyl groups
EXW53_23025	COG1404	Belongs to the peptidase S8 family
EXW53_23030	COG1404	Belongs to the peptidase S8 family
EXW53_23035	COG1404	Belongs to the peptidase S8 family
EXW53_23040	COG2197	response regulator
EXW53_23045	COG4585	Histidine kinase
EXW53_23070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW53_23075	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW53_23105	COG5002	protein histidine kinase activity
EXW53_23110	COG3852	Histidine kinase
EXW53_23115	COG0753	catalase activity
EXW53_23120	COG2267	carboxylic ester hydrolase activity
EXW53_23125	COG1368	sulfuric ester hydrolase activity
EXW53_23135	COG4895	conserved protein (DUF2196)
EXW53_23150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW53_23155	COG1116	anion transmembrane transporter activity
EXW53_23160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW53_23180	COG0494	nUDIX hydrolase
EXW53_23210	COG2723	6-phospho-beta-galactosidase activity
EXW53_23215	COG2723	6-phospho-beta-galactosidase activity
EXW53_23220	COG2190	(PTS) system
EXW53_23220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW53_23220	COG1263	PTS System
EXW53_23225	COG3711	transcriptional antiterminator
EXW53_23230	COG1854	S-ribosylhomocysteine lyase activity
EXW53_23240	COG0288	reversible hydration of carbon dioxide
EXW53_23245	COG1271	oxidase subunit
EXW53_23250	COG1294	oxidase, subunit
EXW53_23265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_23290	COG1842	Phage shock protein A
EXW53_23315	COG3859	Proton-coupled thiamine transporter YuaJ
EXW53_23320	COG5002	protein histidine kinase activity
EXW53_23325	COG0745	RESPONSE REGULATOR receiver
EXW53_23350	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW53_23355	COG1597	lipid kinase activity
EXW53_23370	COG1136	(ABC) transporter
EXW53_23385	COG5002	protein histidine kinase activity
EXW53_23395	COG0586	Pfam SNARE associated Golgi protein
EXW53_23400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW53_23405	COG0577	efflux transmembrane transporter activity
EXW53_23410	COG1136	(ABC) transporter
EXW53_23415	COG3708	Transcriptional regulator
EXW53_23415	COG2207	Transcriptional regulator
EXW53_23425	COG1131	(ABC) transporter
EXW53_23435	COG5658	integral membrane protein
EXW53_23440	COG0640	Transcriptional regulator
EXW53_23445	COG0745	RESPONSE REGULATOR receiver
EXW53_23450	COG2205	protein histidine kinase activity
EXW53_23455	COG0577	efflux transmembrane transporter activity
EXW53_23460	COG0577	efflux transmembrane transporter activity
EXW53_23465	COG1136	(ABC) transporter
EXW53_23470	COG0577	efflux transmembrane transporter activity
EXW53_23480	COG2188	Transcriptional regulator
EXW53_23500	COG3964	amidohydrolase
EXW53_23525	COG4948	Mandelate Racemase Muconate Lactonizing
EXW53_23530	COG0318	PFAM AMP-dependent synthetase and ligase
EXW53_23535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW53_23540	COG0596	Alpha beta hydrolase
EXW53_23545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW53_23550	COG1169	isochorismate synthase
EXW53_23555	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW53_23560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW53_23565	COG1278	Cold shock
EXW53_23575	COG1051	belongs to the nudix hydrolase family
EXW53_23585	COG0058	SHG alpha-glucan phosphorylase activity
EXW53_23595	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW53_23600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW53_23605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW53_23710	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW53_23745	COG1285	pathogenesis
EXW53_23750	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW53_23760	COG0166	Belongs to the GPI family
EXW53_23765	COG2155	Conserved Protein
EXW53_23770	COG1098	S1 RNA binding domain
EXW53_23775	COG0436	Aminotransferase
EXW53_23780	COG1522	sequence-specific DNA binding
EXW53_23785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW53_23790	COG2267	carboxylic ester hydrolase activity
EXW53_23800	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW53_23820	COG5018	Exonuclease
EXW53_23825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW53_23845	COG2050	protein possibly involved in aromatic compounds catabolism
EXW53_23855	COG1268	BioY protein
EXW53_23860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW53_23865	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW53_23875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW53_23890	COG2076	Multidrug Resistance protein
EXW53_23895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EXW53_23900	COG3584	3D domain protein
EXW53_23915	COG1252	NADH dehydrogenase
EXW53_23920	COG0492	ferredoxin-NADP+ reductase activity
EXW53_23925	COG3708	Transcriptional regulator
EXW53_23940	COG1683	Conserved Protein
EXW53_23950	COG0316	Belongs to the HesB IscA family
EXW53_23955	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW53_23960	COG4844	belongs to the
EXW53_23965	COG1252	NADH dehydrogenase
EXW53_23975	COG2274	protein secretion by the type I secretion system
EXW53_23980	COG0390	transport system, permease component
EXW53_23985	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW53_24005	COG4837	Protein of unknown function (DUF1462)
EXW53_24010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW53_24020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW53_24025	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW53_24040	COG0577	efflux transmembrane transporter activity
EXW53_24040	COG1136	(ABC) transporter
EXW53_24045	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW53_24055	COG0647	UMP catabolic process
EXW53_24065	COG2445	Protein of unknown function DUF86
EXW53_24070	COG1494	fructose-1,6-bisphosphatase
EXW53_24090	COG4470	Protein conserved in bacteria
EXW53_24100	COG0789	Transcriptional regulator
EXW53_24105	COG4377	Putative membrane peptidase family (DUF2324)
EXW53_24130	COG0739	heme binding
EXW53_24140	COG3377	Domain of unknown function (DUF1805)
EXW53_24145	COG0737	Belongs to the 5'-nucleotidase family
EXW53_24150	COG0719	Fe-S assembly protein
EXW53_24155	COG0822	iron-sulfur transferase activity
EXW53_24160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW53_24165	COG0719	Fe-S assembly protein
EXW53_24170	COG0396	ATPase activity
EXW53_24175	COG1464	Belongs to the NlpA lipoprotein family
EXW53_24180	COG1464	Belongs to the NlpA lipoprotein family
EXW53_24185	COG2011	ABC-type metal ion transport system permease component
EXW53_24200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW53_24205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW53_24210	COG0509	glycine decarboxylation via glycine cleavage system
EXW53_24215	COG1393	Belongs to the ArsC family
EXW53_24255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW53_24260	COG1960	acyl-CoA dehydrogenase activity
EXW53_24265	COG0183	Belongs to the thiolase family
EXW53_24270	COG1024	Enoyl-CoA hydratase
EXW53_24270	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW53_24280	COG1686	Belongs to the peptidase S11 family
EXW53_24285	COG0506	proline dehydrogenase activity
EXW53_24295	COG0011	TIGRFAM Protein of
EXW53_24300	COG0840	transmembrane signaling receptor activity
EXW53_24310	COG2814	Major facilitator Superfamily
EXW53_24315	COG0531	amino acid
EXW53_24335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW53_24365	COG0586	Pfam SNARE associated Golgi protein
EXW53_24375	COG1376	ErfK ybiS ycfS ynhG family protein
EXW53_24380	COG0745	RESPONSE REGULATOR receiver
EXW53_24385	COG5002	protein histidine kinase activity
EXW53_24395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW53_24405	COG0840	transmembrane signaling receptor activity
EXW53_24410	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW53_24415	COG3227	Zinc metalloprotease (Elastase)
EXW53_24435	COG0586	Pfam SNARE associated Golgi protein
EXW53_24440	COG0475	glutathione-regulated potassium exporter activity
EXW53_24445	COG0490	domain, Protein
EXW53_24450	COG1115	amino acid carrier protein
EXW53_24455	COG0783	Belongs to the Dps family
EXW53_24465	COG2318	DinB family
EXW53_24475	COG1611	Belongs to the LOG family
EXW53_24485	COG1528	Iron-storage protein
EXW53_24490	COG2311	Membrane
EXW53_24495	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_24500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_24505	COG1115	amino acid carrier protein
EXW53_24510	COG1115	amino acid carrier protein
EXW53_24515	COG2910	NAD(P)H-binding
EXW53_24525	COG0656	L-ascorbic acid biosynthetic process
EXW53_24530	COG2814	Major facilitator Superfamily
EXW53_24535	COG1733	regulation of RNA biosynthetic process
EXW53_24545	COG1252	NADH dehydrogenase
EXW53_24570	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXW53_24590	COG3655	Transcriptional regulator
EXW53_24605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW53_24615	COG1733	regulation of RNA biosynthetic process
EXW53_24620	COG1522	sequence-specific DNA binding
EXW53_24625	COG0288	reversible hydration of carbon dioxide
EXW53_24630	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW53_24635	COG2233	PERMEase
EXW53_24675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW53_24680	COG0557	exoribonuclease II activity
EXW53_24685	COG1647	Serine aminopeptidase, S33
EXW53_24690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW53_24695	COG1346	cytolysis
EXW53_24720	COG0149	triose-phosphate isomerase activity
EXW53_24725	COG0126	phosphoglycerate kinase activity
EXW53_24730	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW53_24745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW53_24770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW53_24785	COG2323	membrane
EXW53_24795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW53_24800	COG1481	regulation of sporulation
EXW53_24805	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW53_24810	COG1660	Displays ATPase and GTPase activities
EXW53_24815	COG1051	belongs to the nudix hydrolase family
EXW53_24825	COG0492	ferredoxin-NADP+ reductase activity
EXW53_24830	COG0457	Tetratricopeptide repeat
EXW53_24835	COG0110	maltose O-acetyltransferase activity
EXW53_24840	COG0546	phosphoglycolate phosphatase activity
EXW53_24845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW53_24850	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW53_24855	COG1950	PFAM Membrane protein of
EXW53_24875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW53_24895	COG0789	Transcriptional regulator
EXW53_24925	COG0583	DNA-binding transcription factor activity
EXW53_24930	COG0789	Transcriptional regulator
EXW53_24935	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW53_24940	COG0488	(ABC) transporter
EXW53_24950	COG1132	(ABC) transporter
EXW53_24955	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW53_24960	COG0583	DNA-binding transcription factor activity
EXW53_24965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW53_24970	COG3409	Peptidoglycan-binding domain 1 protein
EXW53_24970	COG0793	Belongs to the peptidase S41A family
EXW53_24975	COG2177	Part of the ABC transporter FtsEX involved in
EXW53_24980	COG2884	Cell division ATP-binding protein ftsE
EXW53_25015	COG1278	Cold shock
EXW53_25020	COG1040	competence protein
EXW53_25025	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW53_25030	COG0791	NLP P60 protein
EXW53_25030	COG1388	LysM domain
EXW53_25035	COG1733	regulation of RNA biosynthetic process
EXW53_25040	COG1307	EDD domain protein, DegV family
EXW53_25045	COG1739	Uncharacterized protein family UPF0029
EXW53_25050	COG1316	TRANSCRIPTIONal
EXW53_25055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW53_25060	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW53_25065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW53_25075	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW53_25075	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW53_25095	COG1486	melibiose metabolic process
EXW53_25100	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW53_25105	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW53_25130	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW53_25140	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW53_25145	COG1301	dicarboxylic acid transport
EXW53_25155	COG0346	lactoylglutathione lyase activity
EXW53_25160	COG1511	domain protein
EXW53_25165	COG0583	DNA-binding transcription factor activity
EXW53_25170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW53_25180	COG1271	oxidase subunit
EXW53_25185	COG1294	oxidase, subunit
EXW53_25195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW53_25200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW53_25205	COG1620	l-lactate permease
EXW53_25215	COG2389	metal-binding protein
EXW53_25225	COG1368	sulfuric ester hydrolase activity
EXW53_25235	COG1388	LysM domain
EXW53_25235	COG0791	NLP P60 protein
EXW53_25240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW53_25250	COG1215	transferase activity, transferring glycosyl groups
EXW53_25255	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW53_25260	COG3584	3D domain protein
EXW53_25260	COG1388	LysM domain
EXW53_25270	COG4715	Zinc finger, swim domain protein
EXW53_25275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW53_25315	COG0577	efflux transmembrane transporter activity
EXW53_25320	COG1136	(ABC) transporter
EXW53_25345	COG3850	Histidine kinase
EXW53_25345	COG5002	protein histidine kinase activity
EXW53_25350	COG0745	RESPONSE REGULATOR receiver
EXW53_25355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW53_25360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW53_25385	COG0463	Glycosyl transferase, family 2
EXW53_25395	COG1216	Glycosyl transferase, family 2
EXW53_25410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW53_25415	COG4464	protein tyrosine phosphatase activity
EXW53_25420	COG0489	protein tyrosine kinase activity
EXW53_25425	COG3944	biosynthesis protein
EXW53_25430	COG0489	protein tyrosine kinase activity
EXW53_25445	COG1609	Transcriptional regulator
EXW53_25455	COG0739	heme binding
EXW53_25470	COG3279	Response regulator of the LytR AlgR family
EXW53_25475	COG2385	sporulation resulting in formation of a cellular spore
EXW53_25490	COG4836	Membrane
EXW53_25495	COG1007	ATP synthesis coupled electron transport
EXW53_25500	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW53_25505	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW53_25510	COG0713	ATP synthesis coupled electron transport
EXW53_25515	COG0839	Belongs to the complex I subunit 6 family
EXW53_25525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW53_25530	COG0649	NAD binding
EXW53_25535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW53_25540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW53_25545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW53_25550	COG5001	Diguanylate cyclase
EXW53_25550	COG3300	MHYT domain
EXW53_25565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW53_25570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW53_25575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW53_25580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW53_25590	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW53_25600	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW53_25625	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW53_25635	COG0698	ribose 5-phosphate isomerase
EXW53_25645	COG2190	(PTS) system
EXW53_25650	COG2259	Doxx family
EXW53_25655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW53_25665	COG1971	Probably functions as a manganese efflux pump
EXW53_25670	COG0009	L-threonylcarbamoyladenylate synthase
EXW53_25690	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW53_25695	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW53_25700	COG1435	thymidine kinase activity
EXW53_25710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW53_25715	COG1494	fructose-1,6-bisphosphatase
EXW53_25735	COG4821	SIS domain
EXW53_25740	COG0504	CTP synthase activity
EXW53_25755	COG1960	acyl-CoA dehydrogenase activity
EXW53_25760	COG1960	acyl-CoA dehydrogenase activity
EXW53_25765	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW53_25770	COG0183	Belongs to the thiolase family
EXW53_25775	COG2181	nitrate reductase activity
EXW53_25775	COG0247	lactate metabolic process
EXW53_25780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW53_25785	COG4294	response to UV
EXW53_25790	COG3300	MHYT domain
EXW53_25790	COG5001	Diguanylate cyclase
EXW53_25805	COG3227	Zinc metalloprotease (Elastase)
EXW53_25810	COG2197	response regulator
EXW53_25815	COG4585	Histidine kinase
EXW53_25820	COG0842	Transport permease protein
EXW53_25825	COG1131	(ABC) transporter
EXW53_25830	COG0024	Methionine aminopeptidase
EXW53_25835	COG2234	aminopeptidase activity
EXW53_25850	COG4506	Protein conserved in bacteria
EXW53_25855	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW53_25870	COG0010	Belongs to the arginase family
EXW53_25880	COG2814	Major facilitator Superfamily
EXW53_25885	COG0789	Transcriptional regulator
EXW53_25890	COG0584	glycerophosphoryl diester phosphodiesterase
EXW53_25895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW53_25905	COG1994	Peptidase M50
EXW53_25915	COG1078	dGTPase activity
EXW53_25920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW53_25925	COG1120	ATPase activity
EXW53_25930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_25935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW53_25940	COG4844	belongs to the
EXW53_25955	COG0280	phosphate acetyltransferase
EXW53_25960	COG3253	May function as heme-dependent peroxidase
EXW53_25970	COG3773	Cell wall hydrolase
EXW53_25980	COG2363	Small membrane protein
EXW53_25990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW53_25995	COG2233	PERMEase
EXW53_26000	COG0561	phosphatase activity
EXW53_26005	COG2814	Major facilitator Superfamily
EXW53_26010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW53_26015	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW53_26020	COG1131	(ABC) transporter
EXW53_26025	COG2755	lipolytic protein G-D-S-L family
EXW53_26030	COG1609	Transcriptional regulator
EXW53_26040	COG0460	homoserine dehydrogenase
EXW53_26045	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW53_26050	COG2873	o-acetylhomoserine
EXW53_26060	COG1011	Hydrolase
EXW53_26065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW53_26075	COG2197	response regulator
EXW53_26080	COG4585	Histidine kinase
EXW53_26080	COG2203	Gaf domain
EXW53_26085	COG0351	phosphomethylpyrimidine kinase
EXW53_26090	COG3706	GGDEF domain
EXW53_26095	COG2879	small protein
EXW53_26100	COG1966	Carbon starvation protein
EXW53_26105	COG3279	Response regulator of the LytR AlgR family
EXW53_26110	COG0477	Major facilitator Superfamily
EXW53_26135	COG0840	transmembrane signaling receptor activity
EXW53_26145	COG1607	acyl-coa hydrolase
EXW53_26150	COG1216	Glycosyl transferase, family 2
EXW53_26160	COG1216	Glycosyl transferase, family 2
EXW53_26180	COG0488	(ABC) transporter
EXW53_26185	COG1309	transcriptional regulator
EXW53_26190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW53_26195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW53_26195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW53_26200	COG0628	permease
EXW53_26210	COG1380	Effector of murein hydrolase LrgA
EXW53_26215	COG3279	Response regulator of the LytR AlgR family
EXW53_26220	COG3275	phosphorelay sensor kinase activity
EXW53_26225	COG2814	Major facilitator Superfamily
EXW53_26230	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW53_26235	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW53_26280	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW53_26285	COG1272	protein, Hemolysin III
EXW53_26310	COG1164	Oligoendopeptidase f
EXW53_26325	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW53_26335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW53_26340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW53_26345	COG4853	Protein conserved in bacteria
EXW53_26355	COG5002	protein histidine kinase activity
EXW53_26360	COG0745	RESPONSE REGULATOR receiver
EXW53_26390	COG0305	Participates in initiation and elongation during chromosome replication
EXW53_26400	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW53_26405	COG4241	membrane
EXW53_26415	COG0629	single-stranded DNA binding
EXW53_26425	COG0012	GTP binding
EXW53_26430	COG4481	Protein conserved in bacteria
EXW53_26435	COG0668	transmembrane transport
EXW53_26445	COG1475	DNA binding
EXW53_26450	COG1192	Involved in chromosome partitioning
EXW53_26455	COG1475	DNA binding
EXW53_26465	COG0445	tRNA wobble uridine modification
EXW53_26470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW53_26475	COG1847	R3H domain protein
EXW53_26480	COG0706	membrane insertase activity
EXW53_26485	COG0594	ribonuclease P activity
EXW53_26490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW53_26595	COG2732	(Barnase) inhibitor
EXW53_26665	COG5002	protein histidine kinase activity
EXW53_26680	COG1279	arginine transmembrane transporter activity
EXW53_26685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW53_26705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW53_26725	COG0531	amino acid
EXW53_26730	COG3338	carbonate dehydratase activity
EXW53_26745	COG5002	protein histidine kinase activity
EXW53_26760	COG5002	protein histidine kinase activity
EXW53_26860	COG4565	transcriptional regulatory protein
EXW53_26865	COG3290	protein histidine kinase activity
EXW53_26900	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EXW53_26920	COG1686	Belongs to the peptidase S11 family
EXW53_27005	COG1476	TRANSCRIPTIONal
EXW53_27065	COG0745	RESPONSE REGULATOR receiver
EXW53_27070	COG5002	protein histidine kinase activity
EXW53_27120	COG0697	spore germination
EXW53_27125	COG0814	amino acid
EXW53_27155	COG1329	Transcriptional regulator
EXW53_27205	COG0494	nUDIX hydrolase
EXW53_27295	COG1192	Involved in chromosome partitioning
EXW53_27320	COG1278	Cold shock
EXW53_27325	COG0662	Cupin 2, conserved barrel domain protein
EXW53_27335	COG2323	membrane