locus-tag	class	description
EXW59_00045	COG2002	toxin-antitoxin pair type II binding
EXW59_00075	COG0457	Tetratricopeptide repeat
EXW59_00085	COG0582	viral genome integration into host DNA
EXW59_00105	COG0741	lytic transglycosylase activity
EXW59_00105	COG0791	NLP P60 protein
EXW59_00110	COG5644	endopeptidase inhibitor activity
EXW59_00120	COG0433	COG0433 Predicted ATPase
EXW59_00180	COG1136	(ABC) transporter
EXW59_00300	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_00365	COG5002	protein histidine kinase activity
EXW59_00370	COG0745	RESPONSE REGULATOR receiver
EXW59_00385	COG3335	DDE superfamily endonuclease
EXW59_00395	COG0577	efflux transmembrane transporter activity
EXW59_00400	COG1136	(ABC) transporter
EXW59_00415	COG2801	Transposase and inactivated derivatives
EXW59_00420	COG2801	Transposase and inactivated derivatives
EXW59_00435	COG0582	viral genome integration into host DNA
EXW59_00455	COG2002	toxin-antitoxin pair type II binding
EXW59_00585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_00595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW59_00600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_00610	COG0697	spore germination
EXW59_00620	COG2002	toxin-antitoxin pair type II binding
EXW59_00655	COG1114	Component of the transport system for branched-chain amino acids
EXW59_00660	COG1115	amino acid carrier protein
EXW59_00710	COG3209	COG3209 Rhs family protein
EXW59_00765	COG2002	toxin-antitoxin pair type II binding
EXW59_00770	COG1923	regulation of RNA biosynthetic process
EXW59_00950	COG0697	spore germination
EXW59_00970	COG4644	lycopene metabolic process
EXW59_01065	COG3344	reverse transcriptase
EXW59_01170	COG3344	reverse transcriptase
EXW59_01235	COG1192	Involved in chromosome partitioning
EXW59_01445	COG2323	membrane
EXW59_01485	COG0673	inositol 2-dehydrogenase activity
EXW59_01490	COG0673	inositol 2-dehydrogenase activity
EXW59_01495	COG2169	Transcriptional regulator
EXW59_01525	COG1674	ftsk spoiiie
EXW59_01525	COG4980	gas vesicle protein
EXW59_01755	COG2311	Membrane
EXW59_01825	COG3344	reverse transcriptase
EXW59_01860	COG0463	Glycosyl transferase, family 2
EXW59_01865	COG0463	Glycosyl transferase, family 2
EXW59_01870	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW59_01875	COG1086	Polysaccharide biosynthesis protein
EXW59_01880	COG1088	dTDP-glucose 4,6-dehydratase activity
EXW59_01885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_01890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXW59_01905	COG2089	acid synthase
EXW59_01910	COG4641	Protein conserved in bacteria
EXW59_01970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_01970	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_01990	COG1136	(ABC) transporter
EXW59_02020	COG0662	Cupin 2, conserved barrel domain protein
EXW59_02085	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_02090	COG3711	transcriptional antiterminator
EXW59_02095	COG2190	(PTS) system
EXW59_02095	COG1263	PTS System
EXW59_02095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_02100	COG2723	6-phospho-beta-galactosidase activity
EXW59_02120	COG2239	Acts as a magnesium transporter
EXW59_02130	COG0772	Belongs to the SEDS family
EXW59_02160	COG0697	spore germination
EXW59_02170	COG1252	NADH dehydrogenase
EXW59_02175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_02175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_02180	COG2002	toxin-antitoxin pair type II binding
EXW59_02195	COG1923	regulation of RNA biosynthetic process
EXW59_02235	COG2814	Major facilitator Superfamily
EXW59_02265	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_02310	COG2002	toxin-antitoxin pair type II binding
EXW59_02325	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXW59_02405	COG1923	regulation of RNA biosynthetic process
EXW59_02435	COG4974	Belongs to the 'phage' integrase family
EXW59_02440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW59_02455	COG2076	Multidrug Resistance protein
EXW59_02460	COG2076	Multidrug Resistance protein
EXW59_02465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW59_02470	COG1073	alpha beta
EXW59_02475	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW59_02485	COG0772	Belongs to the SEDS family
EXW59_02490	COG2239	Acts as a magnesium transporter
EXW59_02500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW59_02510	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW59_02530	COG0745	RESPONSE REGULATOR receiver
EXW59_02565	COG1846	Transcriptional regulator
EXW59_02570	COG2814	Major facilitator Superfamily
EXW59_02590	COG4974	Belongs to the 'phage' integrase family
EXW59_02610	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_02695	COG0745	RESPONSE REGULATOR receiver
EXW59_02705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_02730	COG2040	homocysteine
EXW59_02735	COG0833	amino acid
EXW59_02750	COG1942	4-Oxalocrotonate Tautomerase
EXW59_02755	COG0583	DNA-binding transcription factor activity
EXW59_02765	COG1846	Transcriptional regulator
EXW59_02775	COG1136	(ABC) transporter
EXW59_02780	COG0577	efflux transmembrane transporter activity
EXW59_02790	COG0741	lytic transglycosylase activity
EXW59_02810	COG1674	ftsk spoiiie
EXW59_02825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW59_02850	COG1533	DNA photolyase activity
EXW59_02885	COG2155	Conserved Protein
EXW59_02910	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW59_02975	COG0756	dUTP diphosphatase activity
EXW59_03030	COG1329	Transcriptional regulator
EXW59_03060	COG2814	Major facilitator Superfamily
EXW59_03065	COG0583	DNA-binding transcription factor activity
EXW59_03085	COG0577	efflux transmembrane transporter activity
EXW59_03090	COG1136	(ABC) transporter
EXW59_03110	COG0463	Glycosyl transferase, family 2
EXW59_03115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EXW59_03120	COG0745	RESPONSE REGULATOR receiver
EXW59_03125	COG5002	protein histidine kinase activity
EXW59_03155	COG0640	Transcriptional regulator
EXW59_03185	COG1329	Transcriptional regulator
EXW59_03195	COG0456	acetyltransferase
EXW59_03220	COG4176	ABC-type proline glycine betaine transport system permease component
EXW59_03225	COG0517	IMP dehydrogenase activity
EXW59_03225	COG4175	Glycine betaine
EXW59_03300	COG0457	Tetratricopeptide repeat
EXW59_03430	COG0697	spore germination
EXW59_03460	COG0457	Tetratricopeptide repeat
EXW59_03535	COG1396	sequence-specific DNA binding
EXW59_03575	COG0326	Molecular chaperone. Has ATPase activity
EXW59_03600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW59_03625	COG2801	Transposase and inactivated derivatives
EXW59_03685	COG0367	asparagine synthase
EXW59_03745	COG0542	response to heat
EXW59_03750	COG3397	chitin binding
EXW59_03835	COG1404	Belongs to the peptidase S8 family
EXW59_03855	COG2814	Major facilitator Superfamily
EXW59_03860	COG2234	aminopeptidase activity
EXW59_03870	COG0363	glucosamine-6-phosphate deaminase activity
EXW59_03885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_03890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_03895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_03905	COG0456	acetyltransferase
EXW59_03940	COG1278	Cold shock
EXW59_03965	COG1695	Transcriptional regulator
EXW59_04035	COG2002	toxin-antitoxin pair type II binding
EXW59_04040	COG1923	regulation of RNA biosynthetic process
EXW59_04095	COG0697	spore germination
EXW59_04110	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_04150	COG0659	secondary active sulfate transmembrane transporter activity
EXW59_04155	COG0288	reversible hydration of carbon dioxide
EXW59_04295	COG0457	Tetratricopeptide repeat
EXW59_04380	COG0791	NLP P60 protein
EXW59_04380	COG0741	lytic transglycosylase activity
EXW59_04500	COG0457	Tetratricopeptide repeat
EXW59_04505	COG0457	Tetratricopeptide repeat
EXW59_04580	COG1923	regulation of RNA biosynthetic process
EXW59_04600	COG2368	4-hydroxyphenylacetate
EXW59_04620	COG2873	o-acetylhomoserine
EXW59_04710	COG0433	COG0433 Predicted ATPase
EXW59_04720	COG5644	endopeptidase inhibitor activity
EXW59_04725	COG0741	lytic transglycosylase activity
EXW59_04725	COG0791	NLP P60 protein
EXW59_04745	COG0582	viral genome integration into host DNA
EXW59_04755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW59_04760	COG0592	DNA-directed DNA polymerase activity
EXW59_04765	COG2501	S4 domain
EXW59_04770	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW59_04775	COG0187	DNA topoisomerase II activity
EXW59_04780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW59_04815	COG0516	GMP reductase activity
EXW59_04815	COG0517	IMP dehydrogenase activity
EXW59_04820	COG1686	Belongs to the peptidase S11 family
EXW59_04825	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW59_04830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW59_04850	COG1428	Deoxynucleoside kinase
EXW59_04855	COG1428	Deoxynucleoside kinase
EXW59_04860	COG1335	isochorismatase
EXW59_04865	COG0590	tRNA wobble adenosine to inosine editing
EXW59_04875	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW59_04880	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW59_04885	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW59_04930	COG1982	Orn Lys Arg decarboxylase major
EXW59_04935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW59_04940	COG0470	DNA polymerase III
EXW59_04945	COG1774	PSP1 C-terminal conserved region
EXW59_04950	COG4467	Involved in initiation control of chromosome replication
EXW59_04955	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW59_04965	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW59_04970	COG2002	toxin-antitoxin pair type II binding
EXW59_04980	COG0084	hydrolase, TatD family'
EXW59_04990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW59_05000	COG4466	Protein conserved in bacteria
EXW59_05010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW59_05015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW59_05020	COG0251	oxidation-reduction process
EXW59_05025	COG2088	sporulation resulting in formation of a cellular spore
EXW59_05030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW59_05050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW59_05055	COG2002	toxin-antitoxin pair type II binding
EXW59_05060	COG2244	polysaccharide biosynthetic process
EXW59_05065	COG3956	TIGRFAM MazG family protein
EXW59_05070	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW59_05090	COG1098	S1 RNA binding domain
EXW59_05105	COG2208	phosphoserine phosphatase activity
EXW59_05115	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW59_05120	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW59_05125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW59_05130	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW59_05135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_05140	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW59_05145	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW59_05150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW59_05155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW59_05160	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW59_05165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW59_05170	COG1396	sequence-specific DNA binding
EXW59_05175	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW59_05180	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW59_05270	COG3880	PFAM UvrB UvrC protein
EXW59_05275	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW59_05280	COG0542	response to heat
EXW59_05285	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW59_05290	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW59_05295	COG4956	integral membrane protein (PIN domain superfamily)
EXW59_05300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW59_05310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW59_05315	COG1045	serine acetyltransferase
EXW59_05320	COG0215	cysteine-tRNA ligase activity
EXW59_05330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW59_05335	COG3688	RNA-binding protein containing a PIN domain
EXW59_05345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW59_05350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW59_05355	COG0250	Participates in transcription elongation, termination and antitermination
EXW59_05360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW59_05365	COG0081	regulation of translation
EXW59_05370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW59_05375	COG0222	ribosome binding
EXW59_05380	COG2813	Specifically methylates the guanine in position
EXW59_05385	COG0085	RNA polymerase activity
EXW59_05390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW59_05395	COG1358	cellular component organization or biogenesis
EXW59_05400	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW59_05410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW59_05415	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW59_05420	COG0051	transcription antitermination factor activity, RNA binding
EXW59_05425	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW59_05430	COG0088	Forms part of the polypeptide exit tunnel
EXW59_05435	COG0089	rRNA binding
EXW59_05440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW59_05445	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW59_05450	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW59_05465	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW59_05470	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW59_05480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW59_05485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW59_05495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW59_05505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW59_05515	COG1841	ribosomal large subunit assembly
EXW59_05520	COG0200	Binds to the 23S rRNA
EXW59_05525	COG0201	protein transport
EXW59_05530	COG0563	adenylate kinase activity
EXW59_05535	COG0024	Methionine aminopeptidase
EXW59_05545	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW59_05550	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW59_05555	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW59_05580	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW59_05590	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW59_05595	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW59_05605	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_05610	COG0489	protein tyrosine kinase activity
EXW59_05620	COG2194	sulfuric ester hydrolase activity
EXW59_05625	COG0726	polysaccharide deacetylase
EXW59_05705	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW59_05710	COG4856	YbbR-like protein
EXW59_05715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW59_05730	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_05730	COG4946	Tricorn protease homolog
EXW59_05730	COG1506	peptidase
EXW59_05740	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_05745	COG2011	ABC-type metal ion transport system permease component
EXW59_05755	COG1464	Belongs to the NlpA lipoprotein family
EXW59_05760	COG0604	alcohol dehydrogenase
EXW59_05770	COG0277	FAD linked oxidase domain protein
EXW59_05775	COG2271	Major facilitator Superfamily
EXW59_05785	COG2814	Major facilitator Superfamily
EXW59_05800	COG0601	transmembrane transport
EXW59_05805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_05810	COG0444	Belongs to the ABC transporter superfamily
EXW59_05815	COG4608	Belongs to the ABC transporter superfamily
EXW59_05820	COG4166	transmembrane transport
EXW59_05830	COG2207	Transcriptional regulator
EXW59_05845	COG4166	transmembrane transport
EXW59_05850	COG4166	transmembrane transport
EXW59_05855	COG0656	L-ascorbic acid biosynthetic process
EXW59_05860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_05875	COG4149	molybdate abc transporter
EXW59_05880	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW59_05885	COG1910	domain protein
EXW59_05900	COG0697	spore germination
EXW59_05915	COG0204	Acyl-transferase
EXW59_05925	COG1609	Transcriptional regulator
EXW59_05935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_05950	COG5298	Protein conserved in bacteria
EXW59_05975	COG0488	(ABC) transporter
EXW59_05985	COG0747	negative chemotaxis
EXW59_05995	COG0601	transmembrane transport
EXW59_06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_06005	COG0444	Belongs to the ABC transporter superfamily
EXW59_06010	COG4608	Belongs to the ABC transporter superfamily
EXW59_06015	COG0561	phosphatase activity
EXW59_06045	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW59_06050	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW59_06060	COG0531	amino acid
EXW59_06065	COG2814	Major facilitator Superfamily
EXW59_06075	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW59_06085	COG4294	response to UV
EXW59_06090	COG0705	Rhomboid family
EXW59_06095	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW59_06100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW59_06105	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW59_06110	COG0864	Transcriptional regulator
EXW59_06115	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW59_06120	COG2183	response to ionizing radiation
EXW59_06220	COG0802	atpase or kinase
EXW59_06225	COG1214	PFAM Peptidase M22, glycoprotease
EXW59_06230	COG0456	acetyltransferase
EXW59_06240	COG0488	(ABC) transporter
EXW59_06245	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW59_06255	COG1266	CAAX protease self-immunity
EXW59_06260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW59_06265	COG0459	protein refolding
EXW59_06270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW59_06270	COG0519	Catalyzes the synthesis of GMP from XMP
EXW59_06275	COG2252	PERMEase
EXW59_06285	COG5002	protein histidine kinase activity
EXW59_06315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW59_06345	COG2226	methyltransferase
EXW59_06365	COG1215	transferase activity, transferring glycosyl groups
EXW59_06390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_06395	COG0506	proline dehydrogenase activity
EXW59_06420	COG0697	spore germination
EXW59_06450	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW59_06455	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW59_06460	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW59_06465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW59_06470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW59_06475	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW59_06480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW59_06485	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW59_06490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW59_06495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW59_06500	COG0138	bifunctional purine biosynthesis protein purh
EXW59_06505	COG0151	Belongs to the GarS family
EXW59_06530	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW59_06535	COG0210	DNA helicase
EXW59_06540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW59_06545	COG4851	CamS sex pheromone cAM373 precursor
EXW59_06555	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_06560	COG1335	isochorismatase
EXW59_06570	COG2011	ABC-type metal ion transport system permease component
EXW59_06575	COG1464	Belongs to the NlpA lipoprotein family
EXW59_06590	COG0003	Pfam Anion-transporting ATPase
EXW59_06595	COG1846	Transcriptional regulator
EXW59_06600	COG4682	membrane
EXW59_06610	COG0154	amidase activity
EXW59_06615	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW59_06620	COG1597	lipid kinase activity
EXW59_06630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW59_06645	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_06650	COG2076	Multidrug Resistance protein
EXW59_06655	COG2309	aminopeptidase activity
EXW59_06670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_06680	COG0582	viral genome integration into host DNA
EXW59_06815	COG0582	viral genome integration into host DNA
EXW59_06935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW59_06940	COG5002	protein histidine kinase activity
EXW59_06945	COG4807	Protein conserved in bacteria
EXW59_06970	COG1757	Na H antiporter
EXW59_06975	COG1473	amidohydrolase
EXW59_06990	COG0450	alkyl hydroperoxide reductase
EXW59_07000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW59_07010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_07015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_07020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_07030	COG0492	ferredoxin-NADP+ reductase activity
EXW59_07045	COG0166	Belongs to the GPI family
EXW59_07070	COG5002	protein histidine kinase activity
EXW59_07090	COG3541	Predicted nucleotidyltransferase
EXW59_07095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_07095	COG0723	plastoquinol--plastocyanin reductase activity
EXW59_07105	COG0765	amino acid transport
EXW59_07110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_07120	COG0840	transmembrane signaling receptor activity
EXW59_07125	COG0277	FAD linked oxidase domain protein
EXW59_07130	COG0366	Alpha amylase catalytic
EXW59_07135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_07135	COG2190	(PTS) system
EXW59_07135	COG1263	PTS System
EXW59_07215	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW59_07225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW59_07240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW59_07245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW59_07250	COG1116	anion transmembrane transporter activity
EXW59_07255	COG0488	(ABC) transporter
EXW59_07290	COG2270	Major facilitator Superfamily
EXW59_07320	COG2310	stress, protein
EXW59_07325	COG2310	stress, protein
EXW59_07330	COG2310	stress, protein
EXW59_07335	COG0861	Integral membrane protein TerC family
EXW59_07345	COG3853	Toxic anion resistance protein (TelA)
EXW59_07355	COG4840	Belongs to the UPF0435 family
EXW59_07370	COG1295	ribonuclease BN
EXW59_07375	COG2217	Heavy metal translocating P-type atpase
EXW59_07380	COG0697	spore germination
EXW59_07400	COG0586	Pfam SNARE associated Golgi protein
EXW59_07415	COG3871	stress protein (general stress protein 26)
EXW59_07420	COG0387	Pfam Sodium calcium exchanger
EXW59_07430	COG0535	radical SAM domain protein
EXW59_07460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW59_07480	COG3829	transcription factor binding
EXW59_07490	COG0833	amino acid
EXW59_07495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW59_07515	COG2066	Belongs to the glutaminase family
EXW59_07525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_07525	COG1263	PTS System
EXW59_07530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_07545	COG1216	Glycosyl transferase, family 2
EXW59_07555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_07555	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW59_07560	COG0463	Glycosyl transferase, family 2
EXW59_07575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW59_07580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW59_07595	COG1228	amidohydrolase
EXW59_07600	COG1090	epimerase
EXW59_07605	COG2137	regulation of response to DNA damage stimulus
EXW59_07630	COG1988	membrane-bound metal-dependent
EXW59_07635	COG1194	a g-specific adenine glycosylase
EXW59_07655	COG3557	Belongs to the UPF0374 family
EXW59_07660	COG1132	(ABC) transporter
EXW59_07665	COG4129	membrane
EXW59_07670	COG0070	glutamate synthase
EXW59_07670	COG0069	glutamate synthase activity
EXW59_07670	COG0067	glutamate synthase
EXW59_07675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW59_07680	COG4555	ABC transporter
EXW59_07700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW59_07705	COG0735	belongs to the Fur family
EXW59_07825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW59_07830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW59_07850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW59_07860	COG2766	serine protein kinase
EXW59_07865	COG2718	Belongs to the UPF0229 family
EXW59_07880	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW59_07885	COG2268	Band 7 protein
EXW59_07895	COG3290	protein histidine kinase activity
EXW59_07900	COG4565	transcriptional regulatory protein
EXW59_07905	COG2851	Citrate transporter
EXW59_07930	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW59_07935	COG3842	ATPase activity
EXW59_07940	COG1175	transmembrane transport
EXW59_07945	COG0395	ABC-type sugar transport system, permease component
EXW59_07955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW59_07960	COG0745	RESPONSE REGULATOR receiver
EXW59_07965	COG5002	protein histidine kinase activity
EXW59_07975	COG4990	cell redox homeostasis
EXW59_07985	COG3290	protein histidine kinase activity
EXW59_07990	COG4565	transcriptional regulatory protein
EXW59_07995	COG3493	citrate carrier protein
EXW59_08000	COG0281	malic enzyme
EXW59_08010	COG0697	spore germination
EXW59_08015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_08025	COG5002	protein histidine kinase activity
EXW59_08030	COG0745	RESPONSE REGULATOR receiver
EXW59_08035	COG0456	acetyltransferase
EXW59_08040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW59_08045	COG3383	formate dehydrogenase (NAD+) activity
EXW59_08050	COG2427	Protein of unknown function (DUF1641)
EXW59_08065	COG0531	amino acid
EXW59_08075	COG0640	Transcriptional regulator
EXW59_08080	COG2217	Heavy metal translocating P-type atpase
EXW59_08085	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW59_08095	COG3227	Zinc metalloprotease (Elastase)
EXW59_08115	COG2720	vancomycin resistance protein
EXW59_08120	COG1316	TRANSCRIPTIONal
EXW59_08125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_08130	COG0346	lactoylglutathione lyase activity
EXW59_08135	COG1253	flavin adenine dinucleotide binding
EXW59_08140	COG1027	Aspartate ammonia-lyase
EXW59_08145	COG1620	l-lactate permease
EXW59_08150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_08170	COG3104	oligopeptide transport
EXW59_08175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_08180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_08185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_08200	COG0156	8-amino-7-oxononanoate synthase activity
EXW59_08205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_08215	COG4548	von Willebrand factor, type A
EXW59_08220	COG0714	Associated with various cellular activities
EXW59_08240	COG0531	amino acid
EXW59_08245	COG2188	Transcriptional regulator
EXW59_08250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_08250	COG1263	PTS System
EXW59_08255	COG0366	Alpha amylase catalytic
EXW59_08270	COG0697	spore germination
EXW59_08275	COG4585	Histidine kinase
EXW59_08280	COG2197	response regulator
EXW59_08285	COG1404	Belongs to the peptidase S8 family
EXW59_08300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_08305	COG1115	amino acid carrier protein
EXW59_08310	COG1126	abc transporter atp-binding protein
EXW59_08315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_08320	COG0765	amino acid transport
EXW59_08325	COG0765	amino acid transport
EXW59_08330	COG0833	amino acid
EXW59_08350	COG2378	regulation of single-species biofilm formation
EXW59_08355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW59_08360	COG5002	protein histidine kinase activity
EXW59_08375	COG0659	secondary active sulfate transmembrane transporter activity
EXW59_08400	COG0601	transmembrane transport
EXW59_08405	COG4608	Belongs to the ABC transporter superfamily
EXW59_08415	COG2271	Major facilitator Superfamily
EXW59_08420	COG1846	Transcriptional regulator
EXW59_08425	COG0477	Major facilitator Superfamily
EXW59_08430	COG1609	Transcriptional regulator
EXW59_08435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW59_08440	COG1869	D-ribose catabolic process
EXW59_08450	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW59_08455	COG1879	ABC-type sugar transport system periplasmic component
EXW59_08485	COG1063	alcohol dehydrogenase
EXW59_08500	COG3568	Endonuclease Exonuclease Phosphatase
EXW59_08530	COG0840	transmembrane signaling receptor activity
EXW59_08535	COG3583	domain protein
EXW59_08535	COG3584	3D domain protein
EXW59_08540	COG1476	TRANSCRIPTIONal
EXW59_08560	COG3104	oligopeptide transport
EXW59_08565	COG1114	Component of the transport system for branched-chain amino acids
EXW59_08580	COG1113	amino acid transport
EXW59_08585	COG2252	PERMEase
EXW59_08600	COG2153	protein acetylation
EXW59_08610	COG0569	domain protein
EXW59_08610	COG0475	glutathione-regulated potassium exporter activity
EXW59_08625	COG1845	cytochrome c oxidase, subunit III
EXW59_08630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW59_08640	COG0833	amino acid
EXW59_08645	COG4990	cell redox homeostasis
EXW59_08660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW59_08665	COG0697	spore germination
EXW59_08670	COG0531	amino acid
EXW59_08680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW59_08685	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW59_08695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW59_08700	COG0573	inorganic phosphate transmembrane transporter activity
EXW59_08705	COG0581	inorganic phosphate transmembrane transporter activity
EXW59_08715	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW59_08835	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW59_08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_08850	COG3103	Sh3 type 3 domain protein
EXW59_08850	COG4991	sh3 domain protein
EXW59_08855	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW59_08860	COG1116	anion transmembrane transporter activity
EXW59_08865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW59_08870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW59_08875	COG0352	thiamine-phosphate diphosphorylase activity
EXW59_08880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_08885	COG2104	thiamine diphosphate biosynthetic process
EXW59_08895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_08900	COG0351	phosphomethylpyrimidine kinase
EXW59_08930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW59_08935	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW59_08940	COG2205	protein histidine kinase activity
EXW59_08950	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW59_08955	COG1129	ABC transporter
EXW59_08960	COG1879	ABC-type sugar transport system periplasmic component
EXW59_08965	COG2252	PERMEase
EXW59_08970	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_09030	COG0778	Nitroreductase
EXW59_09035	COG2719	SpoVR family
EXW59_09055	COG1937	Protein conserved in bacteria
EXW59_09060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_09060	COG0425	Belongs to the sulfur carrier protein TusA family
EXW59_09065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_09065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_09070	COG0425	Belongs to the sulfur carrier protein TusA family
EXW59_09075	COG0425	Belongs to the sulfur carrier protein TusA family
EXW59_09075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_09080	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_09085	COG2210	Belongs to the sulfur carrier protein TusA family
EXW59_09090	COG0730	response to heat
EXW59_09100	COG1316	TRANSCRIPTIONal
EXW59_09105	COG0604	alcohol dehydrogenase
EXW59_09110	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW59_09120	COG2814	Major facilitator Superfamily
EXW59_09135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_09135	COG3711	transcriptional antiterminator
EXW59_09140	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW59_09145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW59_09165	COG1388	LysM domain
EXW59_09165	COG3584	3D domain protein
EXW59_09170	COG0577	efflux transmembrane transporter activity
EXW59_09175	COG1136	(ABC) transporter
EXW59_09185	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW59_09200	COG0577	efflux transmembrane transporter activity
EXW59_09205	COG1114	Component of the transport system for branched-chain amino acids
EXW59_09210	COG3546	catalase activity
EXW59_09235	COG0586	Pfam SNARE associated Golgi protein
EXW59_09265	COG0531	amino acid
EXW59_09270	COG0475	glutathione-regulated potassium exporter activity
EXW59_09280	COG1737	Transcriptional regulator
EXW59_09285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW59_09290	COG1263	PTS System
EXW59_09290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_09300	COG2259	Doxx family
EXW59_09320	COG0697	spore germination
EXW59_09325	COG1522	sequence-specific DNA binding
EXW59_09350	COG2076	Multidrug Resistance protein
EXW59_09355	COG1309	transcriptional regulator
EXW59_09360	COG2814	Major facilitator Superfamily
EXW59_09365	COG1733	regulation of RNA biosynthetic process
EXW59_09385	COG4533	DNA binding
EXW59_09390	COG2211	Major facilitator Superfamily
EXW59_09400	COG0693	protein deglycase activity
EXW59_09410	COG0531	amino acid
EXW59_09415	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_09430	COG1132	(ABC) transporter
EXW59_09435	COG1132	(ABC) transporter
EXW59_09440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_09445	COG0765	amino acid transport
EXW59_09450	COG1126	abc transporter atp-binding protein
EXW59_09465	COG0189	ligase activity
EXW59_09475	COG4399	Belongs to the UPF0754 family
EXW59_09480	COG3679	Belongs to the UPF0342 family
EXW59_09495	COG0028	Belongs to the TPP enzyme family
EXW59_09500	COG3527	Alpha-acetolactate decarboxylase
EXW59_09505	COG0463	Glycosyl transferase, family 2
EXW59_09510	COG1216	Glycosyl transferase, family 2
EXW59_09515	COG2094	Belongs to the DNA glycosylase MPG family
EXW59_09520	COG0561	phosphatase activity
EXW59_09530	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW59_09535	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_09540	COG0586	Pfam SNARE associated Golgi protein
EXW59_09550	COG0789	Transcriptional regulator
EXW59_09550	COG4978	Transcriptional regulator
EXW59_09560	COG0659	secondary active sulfate transmembrane transporter activity
EXW59_09575	COG0653	protein targeting
EXW59_09580	COG2244	polysaccharide biosynthetic process
EXW59_09590	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_09610	COG1696	Membrane protein involved in D-alanine export
EXW59_09625	COG1024	Enoyl-CoA hydratase
EXW59_09640	COG1363	Peptidase, m42
EXW59_09655	COG2318	DinB family
EXW59_09675	COG0579	oxidoreductase
EXW59_09710	COG0601	transmembrane transport
EXW59_09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_09720	COG0444	Belongs to the ABC transporter superfamily
EXW59_09725	COG4608	Belongs to the ABC transporter superfamily
EXW59_09755	COG0582	viral genome integration into host DNA
EXW59_09890	COG0477	Major facilitator Superfamily
EXW59_09895	COG3290	protein histidine kinase activity
EXW59_09900	COG4565	transcriptional regulatory protein
EXW59_09905	COG3181	Tripartite tricarboxylate transporter family receptor
EXW59_09910	COG0494	nUDIX hydrolase
EXW59_09960	COG0305	Participates in initiation and elongation during chromosome replication
EXW59_09990	COG1309	transcriptional regulator
EXW59_09995	COG1902	pentaerythritol trinitrate reductase activity
EXW59_10000	COG1073	alpha beta
EXW59_10020	COG1842	Phage shock protein A
EXW59_10030	COG0477	Major facilitator Superfamily
EXW59_10120	COG2732	(Barnase) inhibitor
EXW59_10125	COG2814	Major facilitator Superfamily
EXW59_10130	COG0640	Transcriptional regulator
EXW59_10170	COG2376	Dihydroxyacetone kinase
EXW59_10185	COG2376	Dihydroxyacetone kinase
EXW59_10195	COG1959	2 iron, 2 sulfur cluster binding
EXW59_10215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_10230	COG2720	vancomycin resistance protein
EXW59_10270	COG3237	CsbD-like
EXW59_10290	COG2172	sigma factor antagonist activity
EXW59_10295	COG1191	sigma factor activity
EXW59_10305	COG2208	phosphoserine phosphatase activity
EXW59_10310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW59_10315	COG0784	Response regulator, receiver
EXW59_10315	COG2205	protein histidine kinase activity
EXW59_10315	COG5002	protein histidine kinase activity
EXW59_10345	COG2807	transmembrane transport
EXW59_10380	COG0420	3'-5' exonuclease activity
EXW59_10385	COG4717	serine-type aminopeptidase activity
EXW59_10390	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW59_10395	COG0346	lactoylglutathione lyase activity
EXW59_10400	COG0346	lactoylglutathione lyase activity
EXW59_10405	COG0457	Tetratricopeptide repeat
EXW59_10415	COG2267	carboxylic ester hydrolase activity
EXW59_10430	COG3620	sequence-specific DNA binding
EXW59_10455	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW59_10460	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW59_10465	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW59_10470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW59_10485	COG1595	DNA-templated transcription, initiation
EXW59_10505	COG3973	AAA domain
EXW59_10510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW59_10525	COG1846	Transcriptional regulator
EXW59_10535	COG0537	adenosine 5'-monophosphoramidase activity
EXW59_10540	COG1131	(ABC) transporter
EXW59_10545	COG4473	ABC transporter
EXW59_10555	COG0247	lactate metabolic process
EXW59_10560	COG1139	Iron-sulfur cluster binding protein
EXW59_10565	COG1556	Lactate utilization protein
EXW59_10580	COG3402	PFAM membrane-flanked domain
EXW59_10585	COG3428	Bacterial PH domain
EXW59_10625	COG3402	PFAM membrane-flanked domain
EXW59_10630	COG3428	Bacterial PH domain
EXW59_10635	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_10640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_10645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW59_10650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW59_10655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW59_10685	COG1309	transcriptional regulator
EXW59_10690	COG1511	domain protein
EXW59_10725	COG2378	regulation of single-species biofilm formation
EXW59_10730	COG1609	Transcriptional regulator
EXW59_10740	COG1234	tRNA 3'-trailer cleavage
EXW59_10745	COG0095	Lipoate-protein ligase
EXW59_10755	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_10770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW59_10780	COG4208	sulfate ABC transporter
EXW59_10790	COG3209	COG3209 Rhs family protein
EXW59_10820	COG1408	metallophosphoesterase
EXW59_10825	COG1078	dGTPase activity
EXW59_10840	COG1595	DNA-templated transcription, initiation
EXW59_10850	COG3708	Transcriptional regulator
EXW59_10850	COG2207	Transcriptional regulator
EXW59_10855	COG2205	protein histidine kinase activity
EXW59_10860	COG0745	RESPONSE REGULATOR receiver
EXW59_10880	COG0501	Belongs to the peptidase M48B family
EXW59_10885	COG0697	spore germination
EXW59_10915	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW59_10920	COG2224	Isocitrate lyase
EXW59_10930	COG1278	Cold shock
EXW59_10945	COG4903	ComK protein
EXW59_10950	COG0398	Pfam SNARE associated Golgi protein
EXW59_10960	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW59_10965	COG1074	ATP-dependent DNA helicase activity
EXW59_11015	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW59_11040	COG0367	asparagine synthase
EXW59_11050	COG0753	catalase activity
EXW59_11055	COG0004	ammonium transporteR
EXW59_11065	COG1666	GTP binding
EXW59_11070	COG2996	Protein conserved in bacteria
EXW59_11075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW59_11085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_11100	COG0561	phosphatase activity
EXW59_11120	COG2267	carboxylic ester hydrolase activity
EXW59_11135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_11140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW59_11145	COG5504	Zn-dependent protease
EXW59_11155	COG0180	Tryptophanyl-tRNA synthetase
EXW59_11170	COG4166	transmembrane transport
EXW59_11175	COG0601	transmembrane transport
EXW59_11180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW59_11185	COG0444	Belongs to the ABC transporter superfamily
EXW59_11190	COG4608	Belongs to the ABC transporter superfamily
EXW59_11195	COG0534	Mate efflux family protein
EXW59_11200	COG4166	transmembrane transport
EXW59_11220	COG0861	Integral membrane protein TerC family
EXW59_11225	COG4862	establishment of competence for transformation
EXW59_11230	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_11240	COG1164	Oligoendopeptidase f
EXW59_11250	COG2346	COG2346, Truncated hemoglobins
EXW59_11255	COG4116	CYTH
EXW59_11265	COG2357	RelA SpoT domain protein
EXW59_11275	COG0564	pseudouridine synthase activity
EXW59_11285	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW59_11290	COG0772	Belongs to the SEDS family
EXW59_11295	COG1216	Glycosyl transferase, family 2
EXW59_11315	COG0463	Glycosyl transferase, family 2
EXW59_11315	COG0457	Tetratricopeptide repeat
EXW59_11335	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW59_11350	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW59_11395	COG2153	protein acetylation
EXW59_11400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW59_11405	COG2382	esterase
EXW59_11430	COG5492	domain, Protein
EXW59_11435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW59_11450	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW59_11450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW59_11455	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW59_11460	COG0134	indole-3-glycerol-phosphate synthase activity
EXW59_11465	COG0135	phosphoribosylanthranilate isomerase activity
EXW59_11470	COG0133	tryptophan synthase activity
EXW59_11475	COG0159	tryptophan synthase activity
EXW59_11485	COG1620	l-lactate permease
EXW59_11515	COG1396	sequence-specific DNA binding
EXW59_11545	COG1846	Transcriptional regulator
EXW59_11550	COG1484	DNA-dependent DNA replication
EXW59_11585	COG0582	viral genome integration into host DNA
EXW59_11610	COG5484	DNA packaging
EXW59_11690	COG4824	toxin secretion phage lysis holin
EXW59_11770	COG2226	methyltransferase
EXW59_11790	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_11795	COG0567	Dehydrogenase, E1 component
EXW59_11800	COG1476	TRANSCRIPTIONal
EXW59_11830	COG4152	abc transporter atp-binding protein
EXW59_11835	COG1668	transmembrane transport
EXW59_11870	COG1686	Belongs to the peptidase S11 family
EXW59_11875	COG0681	Belongs to the peptidase S26 family
EXW59_11910	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_11920	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW59_11925	COG1177	transmembrane transport
EXW59_11930	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW59_11940	COG2409	Drug exporters of the RND superfamily
EXW59_11950	COG0564	pseudouridine synthase activity
EXW59_11960	COG2340	Cysteine-rich secretory protein family
EXW59_11965	COG0247	lactate metabolic process
EXW59_11970	COG0277	FAD linked oxidase domain protein
EXW59_11975	COG3835	regulator
EXW59_11985	COG0745	RESPONSE REGULATOR receiver
EXW59_11990	COG5002	protein histidine kinase activity
EXW59_11995	COG2186	Transcriptional regulator
EXW59_12000	COG0247	lactate metabolic process
EXW59_12005	COG1139	Iron-sulfur cluster binding protein
EXW59_12010	COG1556	Lactate utilization protein
EXW59_12015	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW59_12025	COG2116	formate transmembrane transporter activity
EXW59_12030	COG0861	Integral membrane protein TerC family
EXW59_12035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW59_12045	COG2030	dehydratase
EXW59_12065	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_12070	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW59_12080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW59_12095	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW59_12100	COG3842	ATPase activity
EXW59_12110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW59_12115	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW59_12125	COG1349	DNA-binding transcription factor activity
EXW59_12135	COG0235	Class ii aldolase
EXW59_12145	COG2861	carbohydrate metabolic process
EXW59_12155	COG3852	Histidine kinase
EXW59_12160	COG1846	Transcriptional regulator
EXW59_12170	COG2318	DinB family
EXW59_12175	COG5002	protein histidine kinase activity
EXW59_12180	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW59_12185	COG0720	synthase
EXW59_12195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW59_12200	COG4873	Protein conserved in bacteria
EXW59_12210	COG0456	acetyltransferase
EXW59_12230	COG1780	Probably involved in ribonucleotide reductase function
EXW59_12245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW59_12250	COG0531	amino acid
EXW59_12255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW59_12270	COG2204	response regulator
EXW59_12275	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_12285	COG1725	Transcriptional regulator
EXW59_12290	COG1131	(ABC) transporter
EXW59_12300	COG1131	(ABC) transporter
EXW59_12305	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW59_12310	COG1266	CAAX protease self-immunity
EXW59_12320	COG1522	sequence-specific DNA binding
EXW59_12330	COG1335	isochorismatase
EXW59_12340	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW59_12345	COG2070	2-Nitropropane dioxygenase
EXW59_12350	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW59_12355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_12360	COG1696	Membrane protein involved in D-alanine export
EXW59_12365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW59_12380	COG0716	FMN binding
EXW59_12405	COG0534	Mate efflux family protein
EXW59_12425	COG1846	Transcriptional regulator
EXW59_12435	COG1301	dicarboxylic acid transport
EXW59_12440	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW59_12450	COG3874	Sporulation protein YtfJ
EXW59_12470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW59_12475	COG0028	Belongs to the TPP enzyme family
EXW59_12480	COG0440	acetolactate synthase activity
EXW59_12490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW59_12500	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW59_12510	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW59_12515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW59_12525	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW59_12530	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW59_12535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW59_12540	COG0107	imidazoleglycerol-phosphate synthase activity
EXW59_12550	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW59_12555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW59_12570	COG1183	phosphatidylcholine synthase activity
EXW59_12575	COG1368	sulfuric ester hydrolase activity
EXW59_12585	COG0019	diaminopimelate decarboxylase activity
EXW59_12595	COG0175	sulfate reduction
EXW59_12600	COG2046	Belongs to the sulfate adenylyltransferase family
EXW59_12605	COG0529	Catalyzes the synthesis of activated sulfate
EXW59_12610	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW59_12630	COG1648	precorrin-2 dehydrogenase activity
EXW59_12635	COG0733	neurotransmitter:sodium symporter activity
EXW59_12655	COG1757	Na H antiporter
EXW59_12675	COG4758	membrane
EXW59_12680	COG4585	Histidine kinase
EXW59_12685	COG2197	response regulator
EXW59_12695	COG1114	Component of the transport system for branched-chain amino acids
EXW59_12705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW59_12750	COG0730	response to heat
EXW59_12755	COG0306	phosphate transporter
EXW59_12760	COG1392	Phosphate transport regulator
EXW59_12765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_12780	COG3852	Histidine kinase
EXW59_12785	COG1801	Protein of unknown function DUF72
EXW59_12795	COG0582	viral genome integration into host DNA
EXW59_12800	COG5002	protein histidine kinase activity
EXW59_12815	COG0392	lysyltransferase activity
EXW59_12815	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW59_12830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW59_12835	COG1686	Belongs to the peptidase S11 family
EXW59_12840	COG2715	membrane protein required for spore maturation
EXW59_12845	COG0700	Nucleoside recognition
EXW59_12850	COG1187	pseudouridine synthase activity
EXW59_12860	COG1333	cytochrome c biogenesis protein
EXW59_12865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW59_12870	COG0745	RESPONSE REGULATOR receiver
EXW59_12875	COG5002	protein histidine kinase activity
EXW59_12880	COG2096	Adenosyltransferase
EXW59_12885	COG4942	peptidase
EXW59_12895	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW59_12900	COG1141	Ferredoxin
EXW59_12910	COG4955	Helix-turn-helix domain
EXW59_12915	COG0514	ATP-dependent DNA helicase (RecQ)
EXW59_12920	COG1266	CAAX protease self-immunity
EXW59_12930	COG1408	metallophosphoesterase
EXW59_12945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW59_12965	COG0492	ferredoxin-NADP+ reductase activity
EXW59_12970	COG0252	asparaginase activity
EXW59_12975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW59_12985	COG1304	FMN binding
EXW59_13015	COG1160	GTP binding
EXW59_13020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW59_13040	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW59_13050	COG0302	gtp cyclohydrolase
EXW59_13055	COG0142	geranyltranstransferase activity
EXW59_13060	COG2226	methyltransferase
EXW59_13065	COG0142	geranyltranstransferase activity
EXW59_13080	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW59_13090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW59_13095	COG0457	Tetratricopeptide repeat
EXW59_13100	COG5582	Belongs to the UPF0302 family
EXW59_13115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW59_13130	COG4347	Protein of unknown function (DUF1405)
EXW59_13145	COG2738	Putative neutral zinc metallopeptidase
EXW59_13155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_13160	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW59_13165	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW59_13170	COG1803	Methylglyoxal synthase
EXW59_13175	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW59_13180	COG0438	transferase activity, transferring glycosyl groups
EXW59_13185	COG0617	tRNA 3'-terminal CCA addition
EXW59_13195	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW59_13200	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW59_13210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW59_13210	COG1199	ATP-dependent helicase activity
EXW59_13230	COG3935	DnaD domain protein
EXW59_13235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW59_13245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_13245	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_13250	COG3331	DNA recombination
EXW59_13285	COG4474	Belongs to the UPF0398 family
EXW59_13290	COG3599	regulation of cell shape
EXW59_13300	COG0116	Belongs to the methyltransferase superfamily
EXW59_13310	COG1199	ATP-dependent helicase activity
EXW59_13315	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW59_13325	COG0024	Methionine aminopeptidase
EXW59_13330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW59_13335	COG2233	PERMEase
EXW59_13340	COG2311	Membrane
EXW59_13345	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW59_13355	COG0456	acetyltransferase
EXW59_13365	COG2897	thiosulfate sulfurtransferase activity
EXW59_13405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW59_13420	COG0454	-acetyltransferase
EXW59_13440	COG0328	RNA-DNA hybrid ribonuclease activity
EXW59_13475	COG3403	YqcI/YcgG family
EXW59_13480	COG1280	lysine exporter protein (LysE YggA)
EXW59_13495	COG3162	membrane
EXW59_13500	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW59_13505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_13515	COG0475	glutathione-regulated potassium exporter activity
EXW59_13520	COG4978	Transcriptional regulator
EXW59_13520	COG0789	Transcriptional regulator
EXW59_13530	COG2323	membrane
EXW59_13535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW59_13565	COG2814	Major facilitator Superfamily
EXW59_13585	COG1923	regulation of RNA biosynthetic process
EXW59_13595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW59_13600	COG1360	Flagellar Motor Protein
EXW59_13605	COG2201	protein-glutamate methylesterase activity
EXW59_13610	COG2198	Histidine kinase
EXW59_13610	COG0643	Histidine kinase
EXW59_13620	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_13620	COG1776	CheC inhibitor of MCP methylation
EXW59_13635	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW59_13655	COG1256	bacterial-type flagellum assembly
EXW59_13660	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW59_13680	COG1815	bacterial-type flagellum-dependent cell motility
EXW59_13685	COG1558	bacterial-type flagellum-dependent cell motility
EXW59_13695	COG1766	The M ring may be actively involved in energy transduction
EXW59_13700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_13710	COG1157	protein secretion by the type III secretion system
EXW59_13730	COG1749	Flagellar hook protein flgE
EXW59_13745	COG0784	Response regulator, receiver
EXW59_13745	COG0835	chemotaxis
EXW59_13770	COG0861	Integral membrane protein TerC family
EXW59_13780	COG3383	formate dehydrogenase (NAD+) activity
EXW59_13785	COG2427	Protein of unknown function (DUF1641)
EXW59_13790	COG5609	conserved protein (DUF2294)
EXW59_13795	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW59_13805	COG2116	formate transmembrane transporter activity
EXW59_13810	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_13815	COG0303	'Molybdopterin
EXW59_13820	COG0314	molybdopterin synthase activity
EXW59_13825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
EXW59_13835	COG0489	protein tyrosine kinase activity
EXW59_13840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW59_13845	COG0741	lytic transglycosylase activity
EXW59_13855	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_13860	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW59_13860	COG1776	CheC inhibitor of MCP methylation
EXW59_13870	COG1338	Plays a role in the flagellum-specific transport system
EXW59_13875	COG1987	bacterial-type flagellum assembly
EXW59_13885	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW59_13890	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW59_13895	COG1419	protein localization to endoplasmic reticulum
EXW59_13900	COG4786	Flagellar basal body rod
EXW59_13915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_13945	COG0412	Dienelactone hydrolase
EXW59_13950	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_13965	COG2814	Major facilitator Superfamily
EXW59_13975	COG0583	DNA-binding transcription factor activity
EXW59_13980	COG3842	ATPase activity
EXW59_14060	COG0367	asparagine synthase
EXW59_14090	COG1802	Transcriptional regulator
EXW59_14095	COG0697	spore germination
EXW59_14100	COG0438	transferase activity, transferring glycosyl groups
EXW59_14100	COG1216	Glycosyl transferase, family 2
EXW59_14105	COG1757	Na H antiporter
EXW59_14115	COG0277	FAD linked oxidase domain protein
EXW59_14135	COG0534	Mate efflux family protein
EXW59_14140	COG3340	Belongs to the peptidase S51 family
EXW59_14160	COG0785	Cytochrome C biogenesis protein
EXW59_14165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_14180	COG3048	D-serine ammonia-lyase activity
EXW59_14185	COG2733	membrane
EXW59_14225	COG1131	(ABC) transporter
EXW59_14245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_14250	COG0528	UMP kinase activity
EXW59_14260	COG1027	Aspartate ammonia-lyase
EXW59_14265	COG0281	malic enzyme
EXW59_14270	COG4191	Histidine kinase
EXW59_14275	COG0784	Response regulator, receiver
EXW59_14280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW59_14295	COG2502	aspartate--ammonia ligase
EXW59_14300	COG3620	sequence-specific DNA binding
EXW59_14335	COG1051	belongs to the nudix hydrolase family
EXW59_14340	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_14350	COG2814	Major facilitator Superfamily
EXW59_14380	COG0477	Major facilitator Superfamily
EXW59_14395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW59_14400	COG2223	nitrite transmembrane transporter activity
EXW59_14405	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_14420	COG2244	polysaccharide biosynthetic process
EXW59_14425	COG0733	neurotransmitter:sodium symporter activity
EXW59_14435	COG5566	PFAM Mor transcription activator
EXW59_14440	COG2323	membrane
EXW59_14460	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW59_14465	COG2132	Multicopper oxidase
EXW59_14475	COG5002	protein histidine kinase activity
EXW59_14480	COG0745	RESPONSE REGULATOR receiver
EXW59_14490	COG0129	dihydroxy-acid dehydratase activity
EXW59_14495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW59_14520	COG2814	Major facilitator Superfamily
EXW59_14525	COG3384	dioxygenase
EXW59_14565	COG4166	transmembrane transport
EXW59_14590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_14610	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW59_14615	COG1054	Belongs to the UPF0176 family
EXW59_14625	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW59_14630	COG0531	amino acid
EXW59_14655	COG2390	Transcriptional regulator
EXW59_14665	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW59_14670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_14675	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW59_14690	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW59_14710	COG0583	DNA-binding transcription factor activity
EXW59_14730	COG0006	proline dipeptidase activity
EXW59_14735	COG2132	Multicopper oxidase
EXW59_14750	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW59_14760	COG0583	DNA-binding transcription factor activity
EXW59_14780	COG1114	Component of the transport system for branched-chain amino acids
EXW59_14790	COG1834	amidinotransferase
EXW59_14800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_14815	COG2372	response to copper ion
EXW59_14815	COG1276	copper resistance
EXW59_14820	COG4549	nuclear export factor GLE1
EXW59_14830	COG0697	spore germination
EXW59_14835	COG0583	DNA-binding transcription factor activity
EXW59_14840	COG1959	2 iron, 2 sulfur cluster binding
EXW59_14845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW59_14850	COG0778	Nitroreductase
EXW59_14865	COG0628	permease
EXW59_14880	COG1231	oxidoreductase activity
EXW59_14885	COG0523	cobalamin synthesis protein
EXW59_14895	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_14900	COG2030	dehydratase
EXW59_14905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_14920	COG0411	ABC transporter
EXW59_14940	COG0583	DNA-binding transcription factor activity
EXW59_14950	COG1942	4-Oxalocrotonate Tautomerase
EXW59_14965	COG0346	lactoylglutathione lyase activity
EXW59_14975	COG1271	oxidase subunit
EXW59_14980	COG1294	oxidase, subunit
EXW59_14985	COG4988	ABC transporter
EXW59_14990	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW59_15020	COG1686	Belongs to the peptidase S11 family
EXW59_15035	COG1388	LysM domain
EXW59_15035	COG0791	NLP P60 protein
EXW59_15045	COG1132	(ABC) transporter
EXW59_15050	COG0745	RESPONSE REGULATOR receiver
EXW59_15055	COG5002	protein histidine kinase activity
EXW59_15060	COG0300	oxidoreductase activity
EXW59_15065	COG4122	O-methyltransferase activity
EXW59_15080	COG5658	integral membrane protein
EXW59_15095	COG0460	homoserine dehydrogenase
EXW59_15105	COG0083	homoserine kinase activity
EXW59_15120	COG1316	TRANSCRIPTIONal
EXW59_15130	COG0745	RESPONSE REGULATOR receiver
EXW59_15135	COG5002	protein histidine kinase activity
EXW59_15150	COG1285	pathogenesis
EXW59_15155	COG1247	-acetyltransferase
EXW59_15175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_15185	COG1082	Xylose isomerase domain protein TIM barrel
EXW59_15195	COG2814	Major facilitator Superfamily
EXW59_15200	COG1279	arginine transmembrane transporter activity
EXW59_15205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_15215	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW59_15245	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW59_15250	COG0577	efflux transmembrane transporter activity
EXW59_15255	COG2002	toxin-antitoxin pair type II binding
EXW59_15260	COG1404	Belongs to the peptidase S8 family
EXW59_15265	COG0640	Transcriptional regulator
EXW59_15270	COG0667	Aldo Keto reductase
EXW59_15315	COG3949	Membrane
EXW59_15320	COG0783	Belongs to the Dps family
EXW59_15335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_15345	COG1231	oxidoreductase activity
EXW59_15350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_15360	COG2267	carboxylic ester hydrolase activity
EXW59_15365	COG2378	regulation of single-species biofilm formation
EXW59_15385	COG4989	oxidoreductase activity
EXW59_15390	COG0523	cobalamin synthesis protein
EXW59_15395	COG0456	acetyltransferase
EXW59_15400	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW59_15415	COG1902	pentaerythritol trinitrate reductase activity
EXW59_15420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW59_15430	COG4166	transmembrane transport
EXW59_15435	COG0346	lactoylglutathione lyase activity
EXW59_15445	COG0406	alpha-ribazole phosphatase activity
EXW59_15455	COG5337	Spore coat protein CotH
EXW59_15460	COG1051	belongs to the nudix hydrolase family
EXW59_15465	COG0586	Pfam SNARE associated Golgi protein
EXW59_15470	COG2244	polysaccharide biosynthetic process
EXW59_15480	COG0701	Predicted permease
EXW59_15485	COG3689	TIGRFAM TIGR03943 family protein
EXW59_15490	COG1607	acyl-coa hydrolase
EXW59_15500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_15515	COG0702	epimerase
EXW59_15520	COG2839	Protein conserved in bacteria
EXW59_15525	COG1253	flavin adenine dinucleotide binding
EXW59_15550	COG1114	Component of the transport system for branched-chain amino acids
EXW59_15555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW59_15575	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_15590	COG1876	peptidase activity
EXW59_15595	COG0494	nUDIX hydrolase
EXW59_15605	COG2211	Major facilitator Superfamily
EXW59_15620	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_15630	COG0561	phosphatase activity
EXW59_15635	COG1846	Transcriptional regulator
EXW59_15640	COG2814	Major facilitator Superfamily
EXW59_15650	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW59_15655	COG4106	trans-aconitate 2-methyltransferase activity
EXW59_15670	COG1819	glycosyl
EXW59_15675	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_15680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_15705	COG0456	acetyltransferase
EXW59_15740	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_15810	COG3874	Sporulation protein YtfJ
EXW59_15835	COG2226	methyltransferase
EXW59_15855	COG1082	Xylose isomerase domain protein TIM barrel
EXW59_15860	COG0346	lactoylglutathione lyase activity
EXW59_15870	COG0604	alcohol dehydrogenase
EXW59_15875	COG1595	DNA-templated transcription, initiation
EXW59_15900	COG0426	domain, Protein
EXW59_15900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW59_15910	COG0386	Belongs to the glutathione peroxidase family
EXW59_15915	COG1305	Transglutaminase-like
EXW59_15920	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW59_15925	COG0714	Associated with various cellular activities
EXW59_15930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW59_15935	COG1140	nitrate reductase beta subunit
EXW59_15940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW59_15945	COG2181	nitrate reductase activity
EXW59_15950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW59_15955	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW59_15960	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_15965	COG0303	'Molybdopterin
EXW59_15970	COG0314	molybdopterin synthase activity
EXW59_15980	COG2223	nitrite transmembrane transporter activity
EXW59_16000	COG1648	precorrin-2 dehydrogenase activity
EXW59_16010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW59_16010	COG1587	Uroporphyrinogen-III synthase
EXW59_16015	COG2146	nitrite reductase [NAD(P)H] activity
EXW59_16020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW59_16025	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW59_16055	COG2359	stage V sporulation protein S
EXW59_16065	COG1418	mRNA catabolic process
EXW59_16070	COG0488	(ABC) transporter
EXW59_16100	COG1413	lyase activity
EXW59_16115	COG2136	Putative SAM-dependent methyltransferase
EXW59_16115	COG2521	methyltransferase
EXW59_16120	COG0018	arginyl-trna synthetase
EXW59_16135	COG2226	methyltransferase
EXW59_16170	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW59_16180	COG0017	Asparaginyl-tRNA synthetase
EXW59_16185	COG0733	neurotransmitter:sodium symporter activity
EXW59_16215	COG2610	gluconate transmembrane transporter activity
EXW59_16225	COG1794	racemase activity, acting on amino acids and derivatives
EXW59_16235	COG0456	acetyltransferase
EXW59_16240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW59_16245	COG1131	(ABC) transporter
EXW59_16250	COG4473	ABC transporter
EXW59_16260	COG0546	phosphoglycolate phosphatase activity
EXW59_16295	COG0768	penicillin binding
EXW59_16310	COG1272	protein, Hemolysin III
EXW59_16315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW59_16320	COG0805	protein transport
EXW59_16330	COG1307	EDD domain protein, DegV family
EXW59_16335	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW59_16340	COG1999	signal sequence binding
EXW59_16345	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW59_16350	COG0367	asparagine synthase
EXW59_16365	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW59_16370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_16375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW59_16395	COG1335	isochorismatase
EXW59_16400	COG1051	belongs to the nudix hydrolase family
EXW59_16410	COG0668	transmembrane transport
EXW59_16415	COG2203	Gaf domain
EXW59_16415	COG4585	Histidine kinase
EXW59_16420	COG2197	response regulator
EXW59_16430	COG1737	Transcriptional regulator
EXW59_16435	COG1064	alcohol dehydrogenase
EXW59_16455	COG1070	Carbohydrate kinase
EXW59_16465	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW59_16485	COG0517	IMP dehydrogenase activity
EXW59_16485	COG1125	glycine betaine transport
EXW59_16490	COG1174	glycine betaine transport
EXW59_16525	COG1253	flavin adenine dinucleotide binding
EXW59_16530	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_16535	COG5506	Protein of unknown function (DUF1694)
EXW59_16550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_16555	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW59_16560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW59_16565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW59_16570	COG0456	acetyltransferase
EXW59_16575	COG3829	transcription factor binding
EXW59_16580	COG1509	lysine 2,3-aminomutase activity
EXW59_16590	COG4479	Belongs to the UPF0346 family
EXW59_16615	COG4991	sh3 domain protein
EXW59_16615	COG0515	serine threonine protein kinase
EXW59_16615	COG3064	Membrane
EXW59_16625	COG0671	phosphoesterase, PA-phosphatase related
EXW59_16630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW59_16635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_16690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW59_16715	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_16735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_16735	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW59_16745	COG2814	Major facilitator Superfamily
EXW59_16755	COG0372	Belongs to the citrate synthase family
EXW59_16760	COG2079	MmgE PrpD family protein
EXW59_16765	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW59_16770	COG1960	acyl-CoA dehydrogenase activity
EXW59_16775	COG2084	Dehydrogenase
EXW59_16780	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_16785	COG1280	lysine exporter protein (LysE YggA)
EXW59_16790	COG1024	Enoyl-CoA hydratase
EXW59_16805	COG0420	3'-5' exonuclease activity
EXW59_16830	COG2223	nitrite transmembrane transporter activity
EXW59_16835	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_16840	COG1169	isochorismate synthase
EXW59_16845	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW59_16850	COG1535	isochorismatase
EXW59_16850	COG3433	isochorismatase activity
EXW59_16855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW59_16860	COG3251	PFAM MbtH domain protein
EXW59_16865	COG2814	Major facilitator Superfamily
EXW59_16880	COG0776	regulation of translation
EXW59_16890	COG2318	DinB family
EXW59_16895	COG1115	amino acid carrier protein
EXW59_16910	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_16925	COG1187	pseudouridine synthase activity
EXW59_16930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW59_16935	COG3655	Transcriptional regulator
EXW59_16945	COG1136	(ABC) transporter
EXW59_16955	COG0596	Alpha beta hydrolase
EXW59_16970	COG0028	Belongs to the TPP enzyme family
EXW59_16995	COG1253	flavin adenine dinucleotide binding
EXW59_17045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW59_17065	COG1846	Transcriptional regulator
EXW59_17080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_17085	COG1309	transcriptional regulator
EXW59_17115	COG1247	-acetyltransferase
EXW59_17145	COG0596	Alpha beta hydrolase
EXW59_17150	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW59_17160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_17190	COG0583	DNA-binding transcription factor activity
EXW59_17195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW59_17245	COG3344	reverse transcriptase
EXW59_17260	COG0583	DNA-binding transcription factor activity
EXW59_17265	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW59_17270	COG2258	MOSC domain
EXW59_17285	COG1132	(ABC) transporter
EXW59_17290	COG1132	(ABC) transporter
EXW59_17310	COG1396	sequence-specific DNA binding
EXW59_17350	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW59_17355	COG1595	DNA-templated transcription, initiation
EXW59_17375	COG1649	PFAM Uncharacterised BCR, COG1649
EXW59_17395	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW59_17400	COG2971	BadF BadG BcrA BcrD
EXW59_17465	COG1309	transcriptional regulator
EXW59_17480	COG1136	(ABC) transporter
EXW59_17480	COG0577	efflux transmembrane transporter activity
EXW59_17485	COG0500	methyltransferase
EXW59_17485	COG3615	Tellurite resistance protein tehB
EXW59_17495	COG0693	protein deglycase activity
EXW59_17505	COG0588	phosphoglycerate mutase activity
EXW59_17525	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW59_17540	COG0110	maltose O-acetyltransferase activity
EXW59_17555	COG1136	(ABC) transporter
EXW59_17580	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_17590	COG1686	Belongs to the peptidase S11 family
EXW59_17615	COG0768	penicillin binding
EXW59_17620	COG0745	RESPONSE REGULATOR receiver
EXW59_17625	COG2205	protein histidine kinase activity
EXW59_17630	COG1136	(ABC) transporter
EXW59_17635	COG0577	efflux transmembrane transporter activity
EXW59_17645	COG1595	DNA-templated transcription, initiation
EXW59_17655	COG0768	penicillin binding
EXW59_17660	COG0768	penicillin binding
EXW59_17695	COG1252	NADH dehydrogenase
EXW59_17700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_17700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_17715	COG0697	spore germination
EXW59_17740	COG3397	chitin binding
EXW59_17745	COG0823	Involved in the tonB-independent uptake of proteins
EXW59_17755	COG1408	metallophosphoesterase
EXW59_17765	COG1131	(ABC) transporter
EXW59_17775	COG1309	transcriptional regulator
EXW59_17785	COG1960	acyl-CoA dehydrogenase activity
EXW59_17790	COG0439	Biotin carboxylase
EXW59_17795	COG0511	ligase activity, forming carbon-carbon bonds
EXW59_17800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW59_17805	COG1024	Enoyl-CoA hydratase
EXW59_17810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW59_17815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW59_17850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_17855	COG0572	uridine kinase
EXW59_17860	COG2318	DinB family
EXW59_17890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_17915	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW59_17940	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_17945	COG1733	regulation of RNA biosynthetic process
EXW59_17965	COG1942	4-Oxalocrotonate Tautomerase
EXW59_17970	COG0583	DNA-binding transcription factor activity
EXW59_17980	COG1309	transcriptional regulator
EXW59_18010	COG0697	spore germination
EXW59_18015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_18045	COG2323	membrane
EXW59_18050	COG2132	Multicopper oxidase
EXW59_18065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_18070	COG0697	spore germination
EXW59_18075	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW59_18080	COG0201	protein transport
EXW59_18090	COG0737	Belongs to the 5'-nucleotidase family
EXW59_18095	COG3227	Zinc metalloprotease (Elastase)
EXW59_18100	COG1523	belongs to the glycosyl hydrolase 13 family
EXW59_18115	COG0076	glutamate decarboxylase activity
EXW59_18120	COG0657	acetylesterase activity
EXW59_18125	COG1073	alpha beta
EXW59_18135	COG0577	efflux transmembrane transporter activity
EXW59_18140	COG1136	(ABC) transporter
EXW59_18170	COG5002	protein histidine kinase activity
EXW59_18175	COG0745	RESPONSE REGULATOR receiver
EXW59_18180	COG1011	Hydrolase
EXW59_18205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_18210	COG1183	phosphatidylcholine synthase activity
EXW59_18225	COG1132	(ABC) transporter
EXW59_18230	COG3961	Belongs to the TPP enzyme family
EXW59_18250	COG0322	excinuclease ABC activity
EXW59_18275	COG2318	DinB family
EXW59_18290	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW59_18315	COG3878	Protein conserved in bacteria
EXW59_18340	COG1051	belongs to the nudix hydrolase family
EXW59_18345	COG0592	DNA-directed DNA polymerase activity
EXW59_18350	COG2816	NAD+ diphosphatase activity
EXW59_18360	COG2223	nitrite transmembrane transporter activity
EXW59_18395	COG0697	spore germination
EXW59_18400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_18415	COG0584	glycerophosphoryl diester phosphodiesterase
EXW59_18440	COG2814	Major facilitator Superfamily
EXW59_18455	COG2375	cellular response to nickel ion
EXW59_18455	COG1132	(ABC) transporter
EXW59_18460	COG1132	(ABC) transporter
EXW59_18495	COG0768	penicillin binding
EXW59_18500	COG0671	phosphoesterase, PA-phosphatase related
EXW59_18505	COG0604	alcohol dehydrogenase
EXW59_18510	COG5002	protein histidine kinase activity
EXW59_18515	COG0745	RESPONSE REGULATOR receiver
EXW59_18525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_18535	COG2205	protein histidine kinase activity
EXW59_18550	COG1122	ATPase activity
EXW59_18555	COG4720	Psort location CytoplasmicMembrane, score
EXW59_18560	COG1794	racemase activity, acting on amino acids and derivatives
EXW59_18565	COG1819	glycosyl
EXW59_18575	COG0768	penicillin binding
EXW59_18580	COG5002	protein histidine kinase activity
EXW59_18585	COG0561	phosphatase activity
EXW59_18635	COG2124	cytochrome p450
EXW59_18685	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW59_18695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_18700	COG0460	homoserine dehydrogenase
EXW59_18720	COG0577	efflux transmembrane transporter activity
EXW59_18725	COG1136	(ABC) transporter
EXW59_18740	COG0488	(ABC) transporter
EXW59_18745	COG0667	Aldo Keto reductase
EXW59_18750	COG0583	DNA-binding transcription factor activity
EXW59_18760	COG2205	protein histidine kinase activity
EXW59_18765	COG0745	RESPONSE REGULATOR receiver
EXW59_18780	COG3773	Cell wall hydrolase
EXW59_18785	COG0604	alcohol dehydrogenase
EXW59_18830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_18845	COG2959	enzyme of heme biosynthesis
EXW59_18875	COG3483	tryptophan 2,3-dioxygenase activity
EXW59_18880	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW59_18885	COG3844	kynureninase activity
EXW59_18890	COG1309	transcriptional regulator
EXW59_18905	COG3284	Transcriptional regulator
EXW59_18920	COG1349	DNA-binding transcription factor activity
EXW59_18940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW59_18945	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_18950	COG0022	dehydrogenase e1 component
EXW59_18955	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW59_18975	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_18980	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_18980	COG0456	acetyltransferase
EXW59_19015	COG4176	ABC-type proline glycine betaine transport system permease component
EXW59_19020	COG4175	Glycine betaine
EXW59_19020	COG0517	IMP dehydrogenase activity
EXW59_19045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW59_19050	COG2153	protein acetylation
EXW59_19055	COG3397	chitin binding
EXW59_19065	COG1819	glycosyl
EXW59_19080	COG2205	protein histidine kinase activity
EXW59_19085	COG2315	Protein conserved in bacteria
EXW59_19140	COG3973	AAA domain
EXW59_19155	COG2105	PFAM AIG2 family protein
EXW59_19160	COG0514	ATP-dependent DNA helicase (RecQ)
EXW59_19180	COG4637	Psort location Cytoplasmic, score
EXW59_19195	COG1227	inorganic diphosphatase activity
EXW59_19200	COG3397	chitin binding
EXW59_19205	COG2318	DinB family
EXW59_19220	COG1162	GTPase activity
EXW59_19225	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW59_19230	COG1115	amino acid carrier protein
EXW59_19235	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_19240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW59_19250	COG3938	Belongs to the proline racemase family
EXW59_19255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_19295	COG0586	Pfam SNARE associated Golgi protein
EXW59_19310	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW59_19315	COG4166	transmembrane transport
EXW59_19325	COG4948	Mandelate Racemase Muconate Lactonizing
EXW59_19345	COG0667	Aldo Keto reductase
EXW59_19390	COG2936	dipeptidyl-peptidase activity
EXW59_19400	COG0745	RESPONSE REGULATOR receiver
EXW59_19420	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_19425	COG1164	Oligoendopeptidase f
EXW59_19450	COG1307	EDD domain protein, DegV family
EXW59_19480	COG1335	isochorismatase
EXW59_19495	COG2814	Major facilitator Superfamily
EXW59_19505	COG1664	Polymer-forming cytoskeletal
EXW59_19510	COG0789	Transcriptional regulator
EXW59_19515	COG4533	DNA binding
EXW59_19520	COG0477	Major facilitator Superfamily
EXW59_19520	COG2814	Major facilitator Superfamily
EXW59_19535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW59_19540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW59_19545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW59_19550	COG0438	transferase activity, transferring glycosyl groups
EXW59_19565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_19570	COG0438	transferase activity, transferring glycosyl groups
EXW59_19575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_19590	COG2261	transglycosylase associated protein
EXW59_19605	COG2226	methyltransferase
EXW59_19640	COG0436	Aminotransferase
EXW59_19645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW59_19670	COG1131	(ABC) transporter
EXW59_19675	COG2188	Transcriptional regulator
EXW59_19720	COG0628	permease
EXW59_19750	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW59_19760	COG0697	spore germination
EXW59_19765	COG2318	DinB family
EXW59_19815	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_19825	COG2814	Major facilitator Superfamily
EXW59_19830	COG1368	sulfuric ester hydrolase activity
EXW59_19845	COG0488	(ABC) transporter
EXW59_19850	COG1033	growth of symbiont in host cell
EXW59_19850	COG2409	Drug exporters of the RND superfamily
EXW59_19860	COG1309	transcriptional regulator
EXW59_19880	COG0287	Prephenate dehydrogenase
EXW59_19895	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW59_19895	COG1605	Chorismate mutase
EXW59_19925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXW59_19940	COG3584	3D domain protein
EXW59_19940	COG1388	LysM domain
EXW59_19950	COG0346	lactoylglutathione lyase activity
EXW59_19960	COG0431	NADPH-dependent FMN reductase
EXW59_19990	COG0579	oxidoreductase
EXW59_19995	COG1879	ABC-type sugar transport system periplasmic component
EXW59_20010	COG1129	ABC transporter
EXW59_20015	COG2390	Transcriptional regulator
EXW59_20030	COG1830	Aldolase
EXW59_20045	COG0346	lactoylglutathione lyase activity
EXW59_20050	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_20075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_20085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW59_20090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW59_20095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_20100	COG3239	Fatty acid desaturase
EXW59_20120	COG3655	Transcriptional regulator
EXW59_20165	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_20170	COG0346	lactoylglutathione lyase activity
EXW59_20200	COG0714	Associated with various cellular activities
EXW59_20220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW59_20225	COG0753	catalase activity
EXW59_20235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW59_20260	COG0714	Associated with various cellular activities
EXW59_20270	COG0778	Nitroreductase
EXW59_20275	COG1846	Transcriptional regulator
EXW59_20300	COG4884	unkown
EXW59_20300	COG3831	ATPase activity
EXW59_20310	COG1136	(ABC) transporter
EXW59_20340	COG2207	Transcriptional regulator
EXW59_20345	COG0456	acetyltransferase
EXW59_20360	COG0697	spore germination
EXW59_20365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_20370	COG1671	Belongs to the UPF0178 family
EXW59_20390	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_20390	COG0456	acetyltransferase
EXW59_20415	COG0730	response to heat
EXW59_20425	COG0833	amino acid
EXW59_20435	COG4335	DNA alkylation repair
EXW59_20465	COG0681	Belongs to the peptidase S26 family
EXW59_20470	COG0768	penicillin binding
EXW59_20480	COG3104	oligopeptide transport
EXW59_20485	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW59_20500	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW59_20505	COG1984	allophanate hydrolase subunit 2
EXW59_20510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW59_20515	COG1414	Transcriptional regulator
EXW59_20545	COG1960	acyl-CoA dehydrogenase activity
EXW59_20560	COG0346	lactoylglutathione lyase activity
EXW59_20570	COG0640	Transcriptional regulator
EXW59_20585	COG3314	Sporulation integral membrane protein YlbJ
EXW59_20610	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW59_20625	COG0574	Belongs to the PEP-utilizing enzyme family
EXW59_20625	COG3848	Pyruvate phosphate dikinase
EXW59_20655	COG1136	(ABC) transporter
EXW59_20690	COG1073	alpha beta
EXW59_20740	COG5002	protein histidine kinase activity
EXW59_20745	COG0745	RESPONSE REGULATOR receiver
EXW59_20760	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW59_20775	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW59_20780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW59_20785	COG1121	(ABC) transporter
EXW59_20800	COG1999	signal sequence binding
EXW59_20805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW59_20810	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW59_20840	COG0798	PFAM Bile acid sodium symporter
EXW59_20845	COG0346	lactoylglutathione lyase activity
EXW59_20850	COG0640	Transcriptional regulator
EXW59_20870	COG3320	Male sterility
EXW59_20870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_20875	COG1309	transcriptional regulator
EXW59_20880	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_20885	COG1522	sequence-specific DNA binding
EXW59_20900	COG0346	lactoylglutathione lyase activity
EXW59_20930	COG2226	methyltransferase
EXW59_20940	COG2814	Major facilitator Superfamily
EXW59_20970	COG0745	RESPONSE REGULATOR receiver
EXW59_20975	COG5002	protein histidine kinase activity
EXW59_20975	COG3850	Histidine kinase
EXW59_21005	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW59_21040	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW59_21060	COG1136	(ABC) transporter
EXW59_21065	COG0577	efflux transmembrane transporter activity
EXW59_21085	COG3850	Histidine kinase
EXW59_21085	COG5002	protein histidine kinase activity
EXW59_21100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_21120	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW59_21140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW59_21200	COG2814	Major facilitator Superfamily
EXW59_21225	COG5444	nuclease activity
EXW59_21305	COG2849	repeat protein
EXW59_21310	COG5444	nuclease activity
EXW59_21350	COG0477	Major facilitator Superfamily
EXW59_21365	COG1846	Transcriptional regulator
EXW59_21370	COG2814	Major facilitator Superfamily
EXW59_21385	COG0789	Transcriptional regulator
EXW59_21420	COG1476	TRANSCRIPTIONal
EXW59_21435	COG1288	antiporter activity
EXW59_21440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW59_21485	COG3718	enzyme involved in inositol metabolism
EXW59_21515	COG0673	inositol 2-dehydrogenase activity
EXW59_21520	COG2814	Major facilitator Superfamily
EXW59_21525	COG1609	Transcriptional regulator
EXW59_21655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_21720	COG4187	Peptidase family M20/M25/M40
EXW59_21725	COG1414	Transcriptional regulator
EXW59_21735	COG0833	amino acid
EXW59_21750	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW59_21755	COG2031	fatty acid transporter
EXW59_21765	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW59_21820	COG1288	antiporter activity
EXW59_21825	COG2356	endonuclease I
EXW59_21830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_21850	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW59_21875	COG1785	Belongs to the alkaline phosphatase family
EXW59_21880	COG0778	Nitroreductase
EXW59_21885	COG1733	regulation of RNA biosynthetic process
EXW59_21905	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_21915	COG1131	(ABC) transporter
EXW59_21945	COG1595	DNA-templated transcription, initiation
EXW59_21960	COG1011	Hydrolase
EXW59_21965	COG2365	Tyrosine phosphatase family
EXW59_21985	COG0346	lactoylglutathione lyase activity
EXW59_21990	COG1940	carbohydrate kinase activity
EXW59_21995	COG0738	Major facilitator superfamily
EXW59_22000	COG0110	maltose O-acetyltransferase activity
EXW59_22015	COG0628	permease
EXW59_22020	COG2261	transglycosylase associated protein
EXW59_22055	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW59_22065	COG1253	flavin adenine dinucleotide binding
EXW59_22070	COG0789	Transcriptional regulator
EXW59_22075	COG0697	spore germination
EXW59_22085	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW59_22090	COG3813	Protein conserved in bacteria
EXW59_22095	COG2706	6-phosphogluconolactonase activity
EXW59_22100	COG1070	Carbohydrate kinase
EXW59_22110	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW59_22115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXW59_22120	COG4702	Belongs to the UPF0303 family
EXW59_22130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_22150	COG0384	phenazine biosynthesis protein PhzF
EXW59_22170	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_22175	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW59_22180	COG1733	regulation of RNA biosynthetic process
EXW59_22195	COG1191	sigma factor activity
EXW59_22225	COG1876	peptidase activity
EXW59_22270	COG0741	lytic transglycosylase activity
EXW59_22300	COG3850	Histidine kinase
EXW59_22300	COG5002	protein histidine kinase activity
EXW59_22305	COG0745	RESPONSE REGULATOR receiver
EXW59_22325	COG0657	acetylesterase activity
EXW59_22335	COG2814	Major facilitator Superfamily
EXW59_22340	COG1309	transcriptional regulator
EXW59_22350	COG3226	Transcriptional regulator
EXW59_22355	COG1280	lysine exporter protein (LysE YggA)
EXW59_22375	COG0814	amino acid
EXW59_22400	COG1151	hydroxylamine reductase activity
EXW59_22430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_22440	COG2072	flavoprotein involved in K transport
EXW59_22480	COG0604	alcohol dehydrogenase
EXW59_22485	COG1113	amino acid transport
EXW59_22495	COG2814	Major facilitator Superfamily
EXW59_22510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_22515	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_22525	COG0534	Mate efflux family protein
EXW59_22530	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_22535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW59_22550	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW59_22555	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW59_22575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_22580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_22585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_22590	COG3739	integral membrane protein
EXW59_22610	COG0583	DNA-binding transcription factor activity
EXW59_22635	COG1193	negative regulation of DNA recombination
EXW59_22655	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW59_22660	COG1164	Oligoendopeptidase f
EXW59_22675	COG0789	Transcriptional regulator
EXW59_22675	COG4978	Transcriptional regulator
EXW59_22685	COG3781	membrane
EXW59_22695	COG2957	Belongs to the agmatine deiminase family
EXW59_22700	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW59_22740	COG3973	AAA domain
EXW59_22750	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW59_22755	COG0640	Transcriptional regulator
EXW59_22760	COG0604	alcohol dehydrogenase
EXW59_22765	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXW59_22775	COG0457	Tetratricopeptide repeat
EXW59_22780	COG2808	Putative FMN-binding domain
EXW59_22785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_22795	COG0277	FAD linked oxidase domain protein
EXW59_22805	COG0825	malonyl-CoA metabolic process
EXW59_22835	COG1285	pathogenesis
EXW59_22845	COG2514	catechol 2,3-dioxygenase activity
EXW59_22850	COG2720	vancomycin resistance protein
EXW59_22875	COG1278	Cold shock
EXW59_22885	COG0716	FMN binding
EXW59_22895	COG0494	nUDIX hydrolase
EXW59_22915	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_22925	COG0165	Argininosuccinate lyase
EXW59_22940	COG4145	pantothenate transmembrane transporter activity
EXW59_22950	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_22955	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_22965	COG1657	PFAM Prenyltransferase squalene oxidase
EXW59_22970	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW59_22975	COG2962	Rard protein
EXW59_22980	COG3326	Membrane
EXW59_23010	COG2226	methyltransferase
EXW59_23015	COG4166	transmembrane transport
EXW59_23020	COG4166	transmembrane transport
EXW59_23025	COG4166	transmembrane transport
EXW59_23030	COG1316	TRANSCRIPTIONal
EXW59_23040	COG1595	DNA-templated transcription, initiation
EXW59_23050	COG1131	(ABC) transporter
EXW59_23070	COG0673	inositol 2-dehydrogenase activity
EXW59_23075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW59_23080	COG0187	DNA topoisomerase II activity
EXW59_23085	COG1832	CoA-binding protein
EXW59_23090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_23095	COG0745	RESPONSE REGULATOR receiver
EXW59_23105	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW59_23105	COG1328	CTP reductase activity
EXW59_23115	COG4841	protein insertion into membrane
EXW59_23120	COG0824	Thioesterase
EXW59_23145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_23165	COG1132	(ABC) transporter
EXW59_23170	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW59_23200	COG2211	Major facilitator Superfamily
EXW59_23210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW59_23225	COG0183	Belongs to the thiolase family
EXW59_23230	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_23235	COG1268	BioY protein
EXW59_23240	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_23255	COG1396	sequence-specific DNA binding
EXW59_23300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_23315	COG5002	protein histidine kinase activity
EXW59_23325	COG0400	carboxylic ester hydrolase activity
EXW59_23330	COG0346	lactoylglutathione lyase activity
EXW59_23340	COG0069	glutamate synthase activity
EXW59_23345	COG1902	pentaerythritol trinitrate reductase activity
EXW59_23355	COG1329	Transcriptional regulator
EXW59_23360	COG0010	Belongs to the arginase family
EXW59_23365	COG1228	amidohydrolase
EXW59_23370	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW59_23375	COG2986	histidine ammonia-lyase
EXW59_23385	COG2226	methyltransferase
EXW59_23415	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW59_23420	COG0785	Cytochrome C biogenesis protein
EXW59_23430	COG1473	amidohydrolase
EXW59_23435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW59_23440	COG1131	(ABC) transporter
EXW59_23450	COG0583	DNA-binding transcription factor activity
EXW59_23460	COG1346	cytolysis
EXW59_23475	COG0730	response to heat
EXW59_23485	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW59_23485	COG3409	Peptidoglycan-binding domain 1 protein
EXW59_23505	COG1132	(ABC) transporter
EXW59_23510	COG1132	(ABC) transporter
EXW59_23515	COG3763	UPF0154 protein
EXW59_23535	COG3639	organic phosphonate transmembrane transporter activity
EXW59_23545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_23550	COG0737	Belongs to the 5'-nucleotidase family
EXW59_23560	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW59_23565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW59_23580	COG1695	Transcriptional regulator
EXW59_23585	COG1132	(ABC) transporter
EXW59_23615	COG0367	asparagine synthase
EXW59_23620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW59_23630	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXW59_23635	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW59_23645	COG3420	alginic acid biosynthetic process
EXW59_23645	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW59_23650	COG1216	Glycosyl transferase, family 2
EXW59_23650	COG1442	glycosyl transferase family 8
EXW59_23675	COG0438	transferase activity, transferring glycosyl groups
EXW59_23685	COG1215	transferase activity, transferring glycosyl groups
EXW59_23690	COG0438	transferase activity, transferring glycosyl groups
EXW59_23695	COG0438	transferase activity, transferring glycosyl groups
EXW59_23700	COG1086	Polysaccharide biosynthesis protein
EXW59_23705	COG0489	protein tyrosine kinase activity
EXW59_23710	COG3944	biosynthesis protein
EXW59_23715	COG0174	glutamine synthetase
EXW59_23720	COG0789	Transcriptional regulator
EXW59_23725	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW59_23730	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW59_23735	COG2860	membrane
EXW59_23740	COG0464	growth
EXW59_23760	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW59_23770	COG1388	LysM domain
EXW59_23770	COG3584	3D domain protein
EXW59_23775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW59_23775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW59_23775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_23780	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW59_23785	COG1349	DNA-binding transcription factor activity
EXW59_23790	COG1979	alcohol dehydrogenase
EXW59_23795	COG2322	membrane
EXW59_23805	COG1113	amino acid transport
EXW59_23820	COG1473	amidohydrolase
EXW59_23825	COG1408	metallophosphoesterase
EXW59_23830	COG2116	formate transmembrane transporter activity
EXW59_23845	COG2217	Heavy metal translocating P-type atpase
EXW59_23850	COG2608	mercury ion transmembrane transporter activity
EXW59_23855	COG1937	Protein conserved in bacteria
EXW59_23875	COG2819	hydrolase of the alpha beta superfamily
EXW59_23880	COG1120	ATPase activity
EXW59_23885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_23890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_23895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_23900	COG0708	Exodeoxyribonuclease III
EXW59_23905	COG2169	Transcriptional regulator
EXW59_23910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW59_23915	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW59_23920	COG2706	6-phosphogluconolactonase activity
EXW59_23925	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW59_23930	COG2364	Membrane
EXW59_23940	COG0346	lactoylglutathione lyase activity
EXW59_23945	COG5001	Diguanylate cyclase
EXW59_23945	COG3300	MHYT domain
EXW59_23965	COG1086	Polysaccharide biosynthesis protein
EXW59_23985	COG1346	cytolysis
EXW59_23995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW59_24000	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_24000	COG0596	Alpha beta hydrolase
EXW59_24005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW59_24020	COG2188	Transcriptional regulator
EXW59_24025	COG2723	6-phospho-beta-galactosidase activity
EXW59_24030	COG0840	transmembrane signaling receptor activity
EXW59_24040	COG3773	Cell wall hydrolase
EXW59_24050	COG1368	sulfuric ester hydrolase activity
EXW59_24055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW59_24065	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW59_24075	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW59_24080	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW59_24090	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW59_24095	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW59_24100	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW59_24105	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW59_24105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW59_24115	COG2359	stage V sporulation protein S
EXW59_24120	COG1692	metallophosphoesterase
EXW59_24125	COG1418	mRNA catabolic process
EXW59_24130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW59_24135	COG1058	Belongs to the CinA family
EXW59_24135	COG1546	Belongs to the CinA family
EXW59_24140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW59_24145	COG1426	Protein conserved in bacteria
EXW59_24160	COG0300	oxidoreductase activity
EXW59_24165	COG0612	Peptidase, M16
EXW59_24170	COG0612	Peptidase, M16
EXW59_24175	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW59_24180	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW59_24185	COG3845	ABC transporter
EXW59_24190	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW59_24195	COG2188	Transcriptional regulator
EXW59_24200	COG1674	ftsk spoiiie
EXW59_24210	COG0740	serine-type endopeptidase activity
EXW59_24215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW59_24225	COG0527	aspartate kinase activity
EXW59_24230	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW59_24235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW59_24240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW59_24245	COG1873	PFAM PRC-barrel domain
EXW59_24250	COG0612	Peptidase, M16
EXW59_24255	COG0726	polysaccharide deacetylase
EXW59_24260	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW59_24270	COG0196	riboflavin kinase activity
EXW59_24280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW59_24285	COG1550	Protein conserved in bacteria
EXW59_24290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW59_24295	COG1358	cellular component organization or biogenesis
EXW59_24300	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW59_24305	COG0195	Participates in both transcription termination and antitermination
EXW59_24310	COG0779	Required for maturation of 30S ribosomal subunits
EXW59_24320	COG0442	prolyl-tRNA aminoacylation
EXW59_24325	COG0750	zinc metalloprotease
EXW59_24335	COG4589	Belongs to the CDS family
EXW59_24345	COG0233	cytoplasmic translational termination
EXW59_24350	COG0528	UMP kinase activity
EXW59_24355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW59_24360	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW59_24365	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW59_24370	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW59_24375	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW59_24380	COG4974	Belongs to the 'phage' integrase family
EXW59_24385	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW59_24390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW59_24395	COG0758	DNA mediated transformation
EXW59_24400	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW59_24405	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW59_24410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW59_24425	COG0335	large ribosomal subunit rRNA binding
EXW59_24430	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW59_24435	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW59_24440	COG1837	Belongs to the UPF0109 family
EXW59_24450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW59_24455	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
EXW59_24460	COG0552	protein localization to endoplasmic reticulum
EXW59_24465	COG1196	nuclear chromosome segregation
EXW59_24470	COG0571	ribonuclease III activity
EXW59_24475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW59_24480	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_24485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW59_24490	COG0416	fatty acid biosynthetic process
EXW59_24495	COG1349	DNA-binding transcription factor activity
EXW59_24495	COG2050	protein possibly involved in aromatic compounds catabolism
EXW59_24500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW59_24505	COG1461	Dihydroxyacetone kinase
EXW59_24510	COG1302	Protein conserved in bacteria
EXW59_24525	COG1564	THIamine pyrophosphokinase
EXW59_24530	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW59_24540	COG2815	serine threonine protein kinase
EXW59_24540	COG0515	serine threonine protein kinase
EXW59_24545	COG0631	protein serine/threonine phosphatase activity
EXW59_24550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW59_24555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW59_24555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW59_24560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW59_24565	COG0242	peptide deformylase activity
EXW59_24570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW59_24575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW59_24580	COG1758	RNA polymerase activity
EXW59_24595	COG1561	YicC-like family, N-terminal region
EXW59_24600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW59_24615	COG0006	proline dipeptidase activity
EXW59_24635	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW59_24655	COG0167	dihydroorotate dehydrogenase activity
EXW59_24660	COG0543	2 iron, 2 sulfur cluster binding
EXW59_24665	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW59_24675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW59_24680	COG0540	Belongs to the ATCase OTCase family
EXW59_24690	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW59_24695	COG0564	pseudouridine synthase activity
EXW59_24700	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW59_24710	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW59_24715	COG3599	regulation of cell shape
EXW59_24720	COG2302	S4 RNA-binding domain
EXW59_24725	COG0762	integral membrane protein
EXW59_24730	COG1799	cell septum assembly
EXW59_24735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW59_24745	COG1873	PFAM PRC-barrel domain
EXW59_24750	COG1191	sigma factor activity
EXW59_24755	COG1191	sigma factor activity
EXW59_24765	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW59_24770	COG0849	cell division
EXW59_24775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW59_24790	COG0772	Belongs to the SEDS family
EXW59_24795	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW59_24800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW59_24805	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW59_24810	COG0768	penicillin binding
EXW59_24815	COG0768	penicillin binding
EXW59_24825	COG0275	rRNA processing
EXW59_24830	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW59_24835	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW59_24840	COG0454	-acetyltransferase
EXW59_24850	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW59_24855	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW59_24965	COG0740	serine-type endopeptidase activity
EXW59_24975	COG4626	Terminase
EXW59_24975	COG1802	Transcriptional regulator
EXW59_25025	COG0582	viral genome integration into host DNA
EXW59_25085	COG2002	toxin-antitoxin pair type II binding
EXW59_25095	COG1484	DNA-dependent DNA replication
EXW59_25115	COG3620	sequence-specific DNA binding
EXW59_25135	COG1396	sequence-specific DNA binding
EXW59_25150	COG0582	viral genome integration into host DNA
EXW59_25155	COG1323	Belongs to the UPF0348 family
EXW59_25160	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW59_25165	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW59_25170	COG3314	Sporulation integral membrane protein YlbJ
EXW59_25180	COG0742	ribosomal rna small subunit methyltransferase
EXW59_25190	COG4471	UPF0298 protein
EXW59_25195	COG3679	Belongs to the UPF0342 family
EXW59_25200	COG0406	alpha-ribazole phosphatase activity
EXW59_25215	COG2340	Cysteine-rich secretory protein family
EXW59_25225	COG3336	cytochrome c oxidase
EXW59_25250	COG0109	protoheme IX farnesyltransferase activity
EXW59_25255	COG1612	heme a metabolic process
EXW59_25260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW59_25270	COG0772	Belongs to the SEDS family
EXW59_25275	COG4838	Belongs to the UPF0358 family
EXW59_25280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW59_25285	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW59_25295	COG4896	Protein conserved in bacteria
EXW59_25310	COG1217	gtp-binding protein TYPA
EXW59_25320	COG0483	inositol monophosphate 1-phosphatase activity
EXW59_25330	COG4493	Belongs to the UPF0637 family
EXW59_25335	COG4476	Belongs to the UPF0223 family
EXW59_25345	COG1982	Orn Lys Arg decarboxylase major
EXW59_25390	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_25395	COG0022	dehydrogenase e1 component
EXW59_25400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW59_25415	COG0561	phosphatase activity
EXW59_25425	COG5503	Protein of unknown function (DUF1447)
EXW59_25430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW59_25435	COG0569	domain protein
EXW59_25445	COG1473	amidohydrolase
EXW59_25450	COG2171	N-acyltransferase activity
EXW59_25455	COG0583	DNA-binding transcription factor activity
EXW59_25460	COG0517	IMP dehydrogenase activity
EXW59_25470	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW59_25480	COG4703	Protein of unknown function (DUF1797)
EXW59_25495	COG2200	EAL domain
EXW59_25500	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_25505	COG1408	metallophosphoesterase
EXW59_25550	COG2814	Major facilitator Superfamily
EXW59_25560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW59_25570	COG3209	COG3209 Rhs family protein
EXW59_25580	COG2205	protein histidine kinase activity
EXW59_25590	COG0436	Aminotransferase
EXW59_25595	COG1609	Transcriptional regulator
EXW59_25600	COG3833	ABC-type maltose transport systems, permease component
EXW59_25605	COG1175	transmembrane transport
EXW59_25610	COG2182	Extracellular solute-binding protein
EXW59_25620	COG0366	Alpha amylase catalytic
EXW59_25625	COG3842	ATPase activity
EXW59_25670	COG0183	Belongs to the thiolase family
EXW59_25705	COG1695	Transcriptional regulator
EXW59_25710	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_25720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW59_25725	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW59_25730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW59_25735	COG0436	Aminotransferase
EXW59_25740	COG1850	ribulose-bisphosphate carboxylase activity
EXW59_25745	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
EXW59_25750	COG0235	Class ii aldolase
EXW59_25755	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW59_25770	COG2084	Dehydrogenase
EXW59_25780	COG2199	diguanylate cyclase activity
EXW59_25785	COG0778	Nitroreductase
EXW59_25810	COG2190	(PTS) system
EXW59_25810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW59_25810	COG1263	PTS System
EXW59_25815	COG3711	transcriptional antiterminator
EXW59_25825	COG2188	Transcriptional regulator
EXW59_25830	COG0363	glucosamine-6-phosphate deaminase activity
EXW59_25835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW59_25845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW59_25855	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW59_25865	COG1547	Domain of unknown function (DUF309)
EXW59_25875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW59_25880	COG4086	secreted protein
EXW59_25885	COG0561	phosphatase activity
EXW59_25890	COG0697	spore germination
EXW59_25905	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_25930	COG0733	neurotransmitter:sodium symporter activity
EXW59_25950	COG1686	Belongs to the peptidase S11 family
EXW59_25960	COG1725	Transcriptional regulator
EXW59_25965	COG1131	(ABC) transporter
EXW59_25985	COG1846	Transcriptional regulator
EXW59_26000	COG0598	Magnesium transport protein CorA
EXW59_26015	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW59_26025	COG4974	Belongs to the 'phage' integrase family
EXW59_26035	COG0735	belongs to the Fur family
EXW59_26040	COG1300	Membrane
EXW59_26060	COG0667	Aldo Keto reductase
EXW59_26065	COG0656	L-ascorbic acid biosynthetic process
EXW59_26070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW59_26070	COG0456	acetyltransferase
EXW59_26080	COG0737	Belongs to the 5'-nucleotidase family
EXW59_26080	COG1525	nuclease
EXW59_26080	COG4085	toxin activity
EXW59_26085	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW59_26095	COG0596	Alpha beta hydrolase
EXW59_26100	COG2056	Na+-H+ antiporter family
EXW59_26105	COG1609	Transcriptional regulator
EXW59_26110	COG0456	acetyltransferase
EXW59_26115	COG1073	alpha beta
EXW59_26135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW59_26135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW59_26140	COG0307	riboflavin synthase, alpha
EXW59_26145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW59_26145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW59_26160	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW59_26165	COG4106	trans-aconitate 2-methyltransferase activity
EXW59_26170	COG1073	alpha beta
EXW59_26170	COG2226	methyltransferase
EXW59_26175	COG0156	8-amino-7-oxononanoate synthase activity
EXW59_26185	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW59_26195	COG1757	Na H antiporter
EXW59_26200	COG0737	Belongs to the 5'-nucleotidase family
EXW59_26210	COG1522	sequence-specific DNA binding
EXW59_26245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW59_26255	COG0300	oxidoreductase activity
EXW59_26260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_26265	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_26270	COG1760	l-serine dehydratase
EXW59_26275	COG1760	l-serine dehydratase
EXW59_26285	COG1234	tRNA 3'-trailer cleavage
EXW59_26310	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW59_26315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_26325	COG1376	ErfK ybiS ycfS ynhG family protein
EXW59_26330	COG4129	membrane
EXW59_26335	COG1126	abc transporter atp-binding protein
EXW59_26340	COG0765	amino acid transport
EXW59_26345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW59_26360	COG2816	NAD+ diphosphatase activity
EXW59_26365	COG2323	membrane
EXW59_26370	COG0772	Belongs to the SEDS family
EXW59_26380	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW59_26385	COG0022	dehydrogenase e1 component
EXW59_26390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW59_26395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW59_26400	COG3426	butyrate kinase activity
EXW59_26410	COG0280	phosphate acetyltransferase
EXW59_26420	COG3290	protein histidine kinase activity
EXW59_26420	COG3829	transcription factor binding
EXW59_26430	COG0584	glycerophosphoryl diester phosphodiesterase
EXW59_26435	COG3093	addiction module antidote protein HigA
EXW59_26475	COG0745	RESPONSE REGULATOR receiver
EXW59_26485	COG0750	zinc metalloprotease
EXW59_26490	COG0497	DNA recombination
EXW59_26495	COG1438	arginine binding
EXW59_26500	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW59_26505	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW59_26510	COG0142	geranyltranstransferase activity
EXW59_26515	COG1722	exodeoxyribonuclease VII activity
EXW59_26520	COG1570	exodeoxyribonuclease VII activity
EXW59_26525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW59_26530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW59_26535	COG1302	Protein conserved in bacteria
EXW59_26540	COG0439	Biotin carboxylase
EXW59_26545	COG0511	ligase activity, forming carbon-carbon bonds
EXW59_26590	COG3854	ATPases associated with a variety of cellular activities
EXW59_26610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW59_26615	COG0006	proline dipeptidase activity
EXW59_26620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW59_26630	COG3872	metal-dependent enzyme
EXW59_26640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW59_26645	COG1321	iron dependent repressor
EXW59_26675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_26685	COG1609	Transcriptional regulator
EXW59_26695	COG2076	Multidrug Resistance protein
EXW59_26700	COG2076	Multidrug Resistance protein
EXW59_26735	COG1725	Transcriptional regulator
EXW59_26750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW59_26755	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW59_26760	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW59_26765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW59_26795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW59_26820	COG4970	Tfp pilus assembly protein FimT
EXW59_26830	COG1459	type II secretion system
EXW59_26835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW59_26890	COG0646	methionine synthase
EXW59_26890	COG1410	methionine synthase
EXW59_26895	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW59_26895	COG0646	methionine synthase
EXW59_26900	COG0626	cystathionine gamma-synthase activity
EXW59_26905	COG0626	cystathionine gamma-synthase activity
EXW59_26920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_26930	COG1940	carbohydrate kinase activity
EXW59_26935	COG4483	Protein conserved in bacteria
EXW59_26940	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW59_26945	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW59_26950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW59_26955	COG0704	Plays a role in the regulation of phosphate uptake
EXW59_26965	COG0581	inorganic phosphate transmembrane transporter activity
EXW59_26970	COG0573	inorganic phosphate transmembrane transporter activity
EXW59_26975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW59_26980	COG0768	penicillin binding
EXW59_26985	COG0477	Major facilitator Superfamily
EXW59_26990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW59_27015	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW59_27020	COG0735	belongs to the Fur family
EXW59_27025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW59_27030	COG1121	(ABC) transporter
EXW59_27035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_27045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW59_27060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW59_27065	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW59_27070	COG2384	SAM-dependent methyltransferase
EXW59_27080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW59_27085	COG0358	DNA primase activity
EXW59_27095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW59_27100	COG0517	IMP dehydrogenase activity
EXW59_27105	COG1381	Involved in DNA repair and RecF pathway recombination
EXW59_27115	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW59_27120	COG0295	cytidine deaminase activity
EXW59_27125	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW59_27130	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW59_27135	COG1480	7TM receptor with intracellular HD hydrolase
EXW59_27140	COG1702	phosphate starvation-inducible protein PhoH
EXW59_27155	COG1610	YqeY-like protein
EXW59_27160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW59_27165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW59_27170	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW59_27180	COG0484	heat shock protein binding
EXW59_27185	COG0443	Heat shock 70 kDa protein
EXW59_27195	COG1420	regulation of RNA biosynthetic process
EXW59_27200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW59_27205	COG1733	regulation of RNA biosynthetic process
EXW59_27210	COG0481	GTPase activity
EXW59_27220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW59_27225	COG0268	Binds directly to 16S ribosomal RNA
EXW59_27230	COG1466	dna polymerase III delta subunit
EXW59_27240	COG2333	competence protein COMEC
EXW59_27240	COG0658	competence protein
EXW59_27245	COG2131	deaminase
EXW59_27250	COG1555	photosystem II stabilization
EXW59_27250	COG1596	polysaccharide export
EXW59_27255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW59_27260	COG2226	methyltransferase
EXW59_27265	COG0799	negative regulation of ribosome biogenesis
EXW59_27270	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW59_27275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW59_27280	COG1534	Rna-binding protein
EXW59_27285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW59_27290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW59_27295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW59_27305	COG0688	phosphatidylethanolamine metabolic process
EXW59_27315	COG1595	DNA-templated transcription, initiation
EXW59_27320	COG2357	RelA SpoT domain protein
EXW59_27330	COG1785	Belongs to the alkaline phosphatase family
EXW59_27340	COG2267	carboxylic ester hydrolase activity
EXW59_27375	COG1404	Belongs to the peptidase S8 family
EXW59_27380	COG3186	Phenylalanine-4-hydroxylase
EXW59_27385	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW59_27390	COG2514	catechol 2,3-dioxygenase activity
EXW59_27395	COG2259	Doxx family
EXW59_27435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_27445	COG1454	alcohol dehydrogenase
EXW59_27445	COG1012	belongs to the aldehyde dehydrogenase family
EXW59_27450	COG0626	cystathionine gamma-synthase activity
EXW59_27455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW59_27460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW59_27465	COG2226	methyltransferase
EXW59_27480	COG0768	penicillin binding
EXW59_27485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW59_27490	COG0572	uridine kinase
EXW59_27495	COG0826	peptidase U32
EXW59_27500	COG0826	peptidase U32
EXW59_27505	COG4122	O-methyltransferase activity
EXW59_27510	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW59_27520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW59_27525	COG4472	Bacterial protein of unknown function (DUF965)
EXW59_27530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW59_27540	COG0628	permease
EXW59_27560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW59_27570	COG0482	sulfurtransferase activity
EXW59_27575	COG1104	cysteine desulfurase activity
EXW59_27580	COG1959	2 iron, 2 sulfur cluster binding
EXW59_27585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW59_27595	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW59_27600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW59_27610	COG1490	D-aminoacyl-tRNA deacylase activity
EXW59_27615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW59_27620	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW59_27625	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW59_27625	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW59_27630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW59_27635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW59_27635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW59_27645	COG2244	polysaccharide biosynthetic process
EXW59_27650	COG2323	membrane
EXW59_27660	COG1862	Preprotein translocase
EXW59_27665	COG0343	queuine tRNA-ribosyltransferase activity
EXW59_27670	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW59_27680	COG2255	four-way junction helicase activity
EXW59_27685	COG0632	four-way junction helicase activity
EXW59_27690	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW59_27720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW59_27725	COG0157	Belongs to the NadC ModD family
EXW59_27730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW59_27735	COG1104	cysteine desulfurase activity
EXW59_27740	COG1827	regulation of RNA biosynthetic process
EXW59_27745	COG2258	MOSC domain
EXW59_27750	COG0077	Prephenate dehydratase
EXW59_27755	COG0577	efflux transmembrane transporter activity
EXW59_27760	COG0577	efflux transmembrane transporter activity
EXW59_27765	COG1136	(ABC) transporter
EXW59_27770	COG5002	protein histidine kinase activity
EXW59_27775	COG0745	RESPONSE REGULATOR receiver
EXW59_27780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW59_27785	COG3290	protein histidine kinase activity
EXW59_27795	COG2868	ribosomal protein
EXW59_27805	COG1530	ribonuclease E activity
EXW59_27810	COG1994	Peptidase M50
EXW59_27815	COG0739	heme binding
EXW59_27820	COG2894	cell division
EXW59_27825	COG0850	regulation of cytokinetic process
EXW59_27840	COG1077	Cell shape determining protein MreB Mrl
EXW59_27845	COG2003	Belongs to the UPF0758 family
EXW59_27850	COG0424	maF-like protein
EXW59_27865	COG0285	dihydrofolate synthase activity
EXW59_27880	COG1388	LysM domain
EXW59_27885	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW59_27890	COG0113	porphobilinogen synthase activity
EXW59_27895	COG1587	Uroporphyrinogen-III synthase
EXW59_27900	COG0181	hydroxymethylbilane synthase activity
EXW59_27905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW59_27910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW59_27915	COG1846	Transcriptional regulator
EXW59_27920	COG1764	response to oxidative stress
EXW59_27925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW59_27935	COG0470	DNA polymerase III
EXW59_27935	COG1067	ATP-dependent peptidase activity
EXW59_27945	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW59_28010	COG0582	viral genome integration into host DNA
EXW59_28065	COG0622	Phosphoesterase
EXW59_28075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW59_28080	COG5401	PFAM Sporulation and spore germination
EXW59_28090	COG2197	response regulator
EXW59_28095	COG2233	PERMEase
EXW59_28100	COG0402	S-adenosylhomocysteine deaminase activity
EXW59_28105	COG1983	PspC domain protein
EXW59_28110	COG1396	sequence-specific DNA binding
EXW59_28115	COG0697	spore germination
EXW59_28125	COG1959	2 iron, 2 sulfur cluster binding
EXW59_28130	COG1668	transmembrane transport
EXW59_28135	COG4152	abc transporter atp-binding protein
EXW59_28140	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW59_28145	COG1360	Flagellar Motor Protein
EXW59_28150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW59_28160	COG1876	peptidase activity
EXW59_28165	COG0824	Thioesterase
EXW59_28170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW59_28175	COG1053	succinate dehydrogenase
EXW59_28180	COG2009	succinate dehydrogenase
EXW59_28185	COG1719	4-vinyl reductase, 4VR
EXW59_28190	COG0322	excinuclease ABC activity
EXW59_28195	COG3118	belongs to the thioredoxin family
EXW59_28200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW59_28205	COG2086	electron transfer activity
EXW59_28210	COG1024	Enoyl-CoA hydratase
EXW59_28215	COG1309	transcriptional regulator
EXW59_28220	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_28245	COG2318	DinB family
EXW59_28265	COG1131	(ABC) transporter
EXW59_28270	COG2205	protein histidine kinase activity
EXW59_28275	COG0745	RESPONSE REGULATOR receiver
EXW59_28280	COG4895	conserved protein (DUF2196)
EXW59_28285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW59_28295	COG2329	Antibiotic biosynthesis monooxygenase
EXW59_28300	COG4509	Sortase family
EXW59_28305	COG1120	ATPase activity
EXW59_28320	COG5386	Cell surface protein
EXW59_28330	COG5386	Cell surface protein
EXW59_28335	COG1114	Component of the transport system for branched-chain amino acids
EXW59_28345	COG1193	negative regulation of DNA recombination
EXW59_28350	COG1796	DNA polymerase
EXW59_28350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW59_28355	COG1286	toxin biosynthetic process
EXW59_28360	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW59_28365	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW59_28400	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW59_28405	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW59_28420	COG1418	mRNA catabolic process
EXW59_28450	COG2814	Major facilitator Superfamily
EXW59_28455	COG1566	PFAM secretion protein HlyD family protein
EXW59_28460	COG1309	transcriptional regulator
EXW59_28465	COG1363	Peptidase, m42
EXW59_28475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW59_28490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW59_28500	COG1484	DNA-dependent DNA replication
EXW59_28505	COG3611	Membrane attachment protein
EXW59_28510	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW59_28515	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW59_28520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW59_28525	COG0237	dephospho-CoA kinase activity
EXW59_28530	COG1971	Probably functions as a manganese efflux pump
EXW59_28540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW59_28540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW59_28545	COG5002	protein histidine kinase activity
EXW59_28550	COG0745	RESPONSE REGULATOR receiver
EXW59_28565	COG0039	L-malate dehydrogenase activity
EXW59_28570	COG0538	isocitrate dehydrogenase activity
EXW59_28575	COG0372	Belongs to the citrate synthase family
EXW59_28595	COG0628	permease
EXW59_28600	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW59_28610	COG0205	6-phosphofructokinase activity
EXW59_28620	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW59_28625	COG1725	Transcriptional regulator
EXW59_28630	COG0281	malic enzyme
EXW59_28635	COG0587	DNA-directed DNA polymerase activity
EXW59_28650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW59_28670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_28680	COG4109	DRTGG domain
EXW59_28685	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW59_28690	COG0006	proline dipeptidase activity
EXW59_28715	COG0662	Cupin 2, conserved barrel domain protein
EXW59_28725	COG1476	TRANSCRIPTIONal
EXW59_28740	COG1028	Short-chain dehydrogenase reductase Sdr
EXW59_28745	COG0589	response to stress
EXW59_28760	COG0165	Argininosuccinate lyase
EXW59_28765	COG0137	argininosuccinate synthase activity
EXW59_28780	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_28800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW59_28805	COG0827	DNA restriction-modification system
EXW59_28810	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW59_28815	COG3874	Sporulation protein YtfJ
EXW59_28830	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW59_28840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW59_28855	COG1104	cysteine desulfurase activity
EXW59_28860	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW59_28870	COG1309	transcriptional regulator
EXW59_28875	COG1956	GAF domain-containing protein
EXW59_28880	COG0626	cystathionine gamma-synthase activity
EXW59_28885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW59_28925	COG1595	DNA-templated transcription, initiation
EXW59_28935	COG0110	maltose O-acetyltransferase activity
EXW59_28940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW59_28945	COG0454	-acetyltransferase
EXW59_28950	COG0517	IMP dehydrogenase activity
EXW59_28955	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW59_28970	COG0745	RESPONSE REGULATOR receiver
EXW59_28980	COG0666	response to abiotic stimulus
EXW59_28990	COG1970	mechanosensitive ion channel activity
EXW59_29015	COG1609	Transcriptional regulator
EXW59_29020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW59_29020	COG1605	Chorismate mutase
EXW59_29025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW59_29025	COG1605	Chorismate mutase
EXW59_29030	COG4851	CamS sex pheromone cAM373 precursor
EXW59_29035	COG3118	belongs to the thioredoxin family
EXW59_29045	COG2309	aminopeptidase activity
EXW59_29065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_29070	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW59_29080	COG1674	ftsk spoiiie
EXW59_29095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW59_29100	COG4848	Belongs to the UPF0354 family
EXW59_29105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_29110	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW59_29115	COG1363	Peptidase, m42
EXW59_29125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_29130	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW59_29140	COG0510	thiamine kinase activity
EXW59_29145	COG1523	belongs to the glycosyl hydrolase 13 family
EXW59_29155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW59_29160	COG1349	DNA-binding transcription factor activity
EXW59_29165	COG1187	pseudouridine synthase activity
EXW59_29170	COG2244	polysaccharide biosynthetic process
EXW59_29175	COG2081	HI0933 family
EXW59_29180	COG2814	Major facilitator Superfamily
EXW59_29190	COG3832	glyoxalase III activity
EXW59_29210	COG1329	Transcriptional regulator
EXW59_29235	COG0314	molybdopterin synthase activity
EXW59_29240	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW59_29245	COG0303	'Molybdopterin
EXW59_29250	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW59_29255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW59_29260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW59_29285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW59_29295	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW59_29335	COG0495	leucyl-tRNA aminoacylation
EXW59_29340	COG2814	Major facilitator Superfamily
EXW59_29345	COG0475	glutathione-regulated potassium exporter activity
EXW59_29350	COG0490	domain, Protein
EXW59_29355	COG0582	viral genome integration into host DNA
EXW59_29370	COG1136	(ABC) transporter
EXW59_29390	COG1242	4 iron, 4 sulfur cluster binding
EXW59_29395	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW59_29415	COG2267	carboxylic ester hydrolase activity
EXW59_29420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW59_29425	COG0671	phosphoesterase, PA-phosphatase related
EXW59_29430	COG0438	transferase activity, transferring glycosyl groups
EXW59_29435	COG0746	molybdenum cofactor guanylyltransferase activity
EXW59_29455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW59_29460	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW59_29500	COG5002	protein histidine kinase activity
EXW59_29505	COG3852	Histidine kinase
EXW59_29510	COG0753	catalase activity
EXW59_29515	COG2267	carboxylic ester hydrolase activity
EXW59_29525	COG1368	sulfuric ester hydrolase activity
EXW59_29535	COG4895	conserved protein (DUF2196)
EXW59_29550	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW59_29555	COG1116	anion transmembrane transporter activity
EXW59_29560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW59_29580	COG0494	nUDIX hydrolase
EXW59_29620	COG2076	Multidrug Resistance protein
EXW59_29625	COG2076	Multidrug Resistance protein
EXW59_29630	COG0789	Transcriptional regulator
EXW59_29635	COG1854	S-ribosylhomocysteine lyase activity
EXW59_29645	COG0288	reversible hydration of carbon dioxide
EXW59_29650	COG1271	oxidase subunit
EXW59_29655	COG1294	oxidase, subunit
EXW59_29680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_29705	COG1842	Phage shock protein A
EXW59_29730	COG3859	Proton-coupled thiamine transporter YuaJ
EXW59_29735	COG5002	protein histidine kinase activity
EXW59_29740	COG0745	RESPONSE REGULATOR receiver
EXW59_29765	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW59_29770	COG1597	lipid kinase activity
EXW59_29810	COG5002	protein histidine kinase activity
EXW59_29820	COG0586	Pfam SNARE associated Golgi protein
EXW59_29835	COG0577	efflux transmembrane transporter activity
EXW59_29840	COG1136	(ABC) transporter
EXW59_29845	COG3708	Transcriptional regulator
EXW59_29845	COG2207	Transcriptional regulator
EXW59_29855	COG1131	(ABC) transporter
EXW59_29860	COG5658	integral membrane protein
EXW59_29865	COG0640	Transcriptional regulator
EXW59_29870	COG0745	RESPONSE REGULATOR receiver
EXW59_29875	COG2205	protein histidine kinase activity
EXW59_29880	COG0577	efflux transmembrane transporter activity
EXW59_29885	COG0577	efflux transmembrane transporter activity
EXW59_29890	COG1136	(ABC) transporter
EXW59_29895	COG0577	efflux transmembrane transporter activity
EXW59_29910	COG2188	Transcriptional regulator
EXW59_29930	COG3964	amidohydrolase
EXW59_29950	COG4948	Mandelate Racemase Muconate Lactonizing
EXW59_29955	COG0318	PFAM AMP-dependent synthetase and ligase
EXW59_29960	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW59_29965	COG0596	Alpha beta hydrolase
EXW59_29970	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW59_29975	COG1169	isochorismate synthase
EXW59_29980	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW59_29985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW59_29990	COG1278	Cold shock
EXW59_30000	COG0789	Transcriptional regulator
EXW59_30015	COG0058	SHG alpha-glucan phosphorylase activity
EXW59_30025	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW59_30030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW59_30035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW59_30045	COG1404	Belongs to the peptidase S8 family
EXW59_30180	COG1285	pathogenesis
EXW59_30185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW59_30195	COG0166	Belongs to the GPI family
EXW59_30205	COG2155	Conserved Protein
EXW59_30210	COG1098	S1 RNA binding domain
EXW59_30215	COG0436	Aminotransferase
EXW59_30220	COG1522	sequence-specific DNA binding
EXW59_30225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW59_30230	COG2267	carboxylic ester hydrolase activity
EXW59_30240	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW59_30255	COG5018	Exonuclease
EXW59_30260	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW59_30280	COG2050	protein possibly involved in aromatic compounds catabolism
EXW59_30290	COG1268	BioY protein
EXW59_30295	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW59_30300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW59_30310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW59_30315	COG3584	3D domain protein
EXW59_30330	COG1252	NADH dehydrogenase
EXW59_30335	COG0492	ferredoxin-NADP+ reductase activity
EXW59_30340	COG3708	Transcriptional regulator
EXW59_30355	COG1683	Conserved Protein
EXW59_30380	COG0316	Belongs to the HesB IscA family
EXW59_30385	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW59_30390	COG4844	belongs to the
EXW59_30395	COG1252	NADH dehydrogenase
EXW59_30405	COG0390	transport system, permease component
EXW59_30410	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW59_30450	COG4837	Protein of unknown function (DUF1462)
EXW59_30455	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW59_30465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW59_30470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW59_30485	COG0577	efflux transmembrane transporter activity
EXW59_30485	COG1136	(ABC) transporter
EXW59_30490	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW59_30500	COG0647	UMP catabolic process
EXW59_30510	COG2445	Protein of unknown function DUF86
EXW59_30515	COG1494	fructose-1,6-bisphosphatase
EXW59_30530	COG4470	Protein conserved in bacteria
EXW59_30540	COG0789	Transcriptional regulator
EXW59_30545	COG4377	Putative membrane peptidase family (DUF2324)
EXW59_30565	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW59_30570	COG0739	heme binding
EXW59_30580	COG3377	Domain of unknown function (DUF1805)
EXW59_30585	COG0737	Belongs to the 5'-nucleotidase family
EXW59_30595	COG0719	Fe-S assembly protein
EXW59_30600	COG0822	iron-sulfur transferase activity
EXW59_30605	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW59_30610	COG0719	Fe-S assembly protein
EXW59_30615	COG0396	ATPase activity
EXW59_30620	COG1464	Belongs to the NlpA lipoprotein family
EXW59_30625	COG1464	Belongs to the NlpA lipoprotein family
EXW59_30630	COG2011	ABC-type metal ion transport system permease component
EXW59_30645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW59_30650	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW59_30660	COG0509	glycine decarboxylation via glycine cleavage system
EXW59_30665	COG1393	Belongs to the ArsC family
EXW59_30700	COG1309	transcriptional regulator
EXW59_30705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW59_30710	COG1960	acyl-CoA dehydrogenase activity
EXW59_30715	COG0183	Belongs to the thiolase family
EXW59_30720	COG1024	Enoyl-CoA hydratase
EXW59_30720	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW59_30730	COG1686	Belongs to the peptidase S11 family
EXW59_30735	COG0506	proline dehydrogenase activity
EXW59_30745	COG0011	TIGRFAM Protein of
EXW59_30750	COG0840	transmembrane signaling receptor activity
EXW59_30765	COG2814	Major facilitator Superfamily
EXW59_30770	COG0531	amino acid
EXW59_30800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW59_30860	COG0586	Pfam SNARE associated Golgi protein
EXW59_30870	COG1376	ErfK ybiS ycfS ynhG family protein
EXW59_30875	COG0745	RESPONSE REGULATOR receiver
EXW59_30880	COG5002	protein histidine kinase activity
EXW59_30890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW59_30900	COG0840	transmembrane signaling receptor activity
EXW59_30905	COG0840	transmembrane signaling receptor activity
EXW59_30910	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW59_30915	COG3227	Zinc metalloprotease (Elastase)
EXW59_30920	COG1741	Belongs to the pirin family
EXW59_30940	COG0475	glutathione-regulated potassium exporter activity
EXW59_30945	COG0490	domain, Protein
EXW59_30950	COG1115	amino acid carrier protein
EXW59_30955	COG0783	Belongs to the Dps family
EXW59_30965	COG2318	DinB family
EXW59_30970	COG1611	Belongs to the LOG family
EXW59_30980	COG1528	Iron-storage protein
EXW59_30985	COG2311	Membrane
EXW59_30990	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_30995	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_31000	COG1115	amino acid carrier protein
EXW59_31005	COG1115	amino acid carrier protein
EXW59_31010	COG2910	NAD(P)H-binding
EXW59_31040	COG0656	L-ascorbic acid biosynthetic process
EXW59_31045	COG2814	Major facilitator Superfamily
EXW59_31050	COG1733	regulation of RNA biosynthetic process
EXW59_31060	COG1252	NADH dehydrogenase
EXW59_31080	COG0840	transmembrane signaling receptor activity
EXW59_31080	COG3290	protein histidine kinase activity
EXW59_31105	COG3655	Transcriptional regulator
EXW59_31120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW59_31130	COG1733	regulation of RNA biosynthetic process
EXW59_31135	COG0778	Nitroreductase
EXW59_31140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW59_31145	COG4224	UPF0291 protein
EXW59_31150	COG1522	sequence-specific DNA binding
EXW59_31155	COG0288	reversible hydration of carbon dioxide
EXW59_31160	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW59_31165	COG2233	PERMEase
EXW59_31210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW59_31220	COG0557	exoribonuclease II activity
EXW59_31225	COG1647	Serine aminopeptidase, S33
EXW59_31230	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW59_31235	COG1346	cytolysis
EXW59_31250	COG0148	phosphopyruvate hydratase activity
EXW59_31260	COG0149	triose-phosphate isomerase activity
EXW59_31265	COG0126	phosphoglycerate kinase activity
EXW59_31270	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW59_31285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW59_31310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW59_31325	COG2323	membrane
EXW59_31335	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW59_31340	COG1481	regulation of sporulation
EXW59_31345	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW59_31350	COG1660	Displays ATPase and GTPase activities
EXW59_31355	COG1051	belongs to the nudix hydrolase family
EXW59_31365	COG0492	ferredoxin-NADP+ reductase activity
EXW59_31370	COG0457	Tetratricopeptide repeat
EXW59_31375	COG0110	maltose O-acetyltransferase activity
EXW59_31380	COG0546	phosphoglycolate phosphatase activity
EXW59_31385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW59_31390	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW59_31395	COG1950	PFAM Membrane protein of
EXW59_31405	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW59_31425	COG0789	Transcriptional regulator
EXW59_31460	COG0583	DNA-binding transcription factor activity
EXW59_31465	COG0789	Transcriptional regulator
EXW59_31470	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW59_31475	COG0488	(ABC) transporter
EXW59_31490	COG1132	(ABC) transporter
EXW59_31495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_31500	COG0793	Belongs to the peptidase S41A family
EXW59_31500	COG3409	Peptidoglycan-binding domain 1 protein
EXW59_31505	COG2177	Part of the ABC transporter FtsEX involved in
EXW59_31510	COG2884	Cell division ATP-binding protein ftsE
EXW59_31545	COG1131	(ABC) transporter
EXW59_31580	COG1278	Cold shock
EXW59_31585	COG1040	competence protein
EXW59_31590	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW59_31595	COG0791	NLP P60 protein
EXW59_31595	COG1388	LysM domain
EXW59_31600	COG1733	regulation of RNA biosynthetic process
EXW59_31605	COG1307	EDD domain protein, DegV family
EXW59_31610	COG1739	Uncharacterized protein family UPF0029
EXW59_31615	COG1316	TRANSCRIPTIONal
EXW59_31620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW59_31625	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW59_31630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW59_31640	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW59_31640	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW59_31660	COG1486	melibiose metabolic process
EXW59_31665	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW59_31670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW59_31690	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW59_31700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW59_31705	COG1301	dicarboxylic acid transport
EXW59_31720	COG1511	domain protein
EXW59_31725	COG0583	DNA-binding transcription factor activity
EXW59_31730	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW59_31735	COG1271	oxidase subunit
EXW59_31740	COG1294	oxidase, subunit
EXW59_31745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW59_31750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW59_31755	COG1620	l-lactate permease
EXW59_31765	COG2389	metal-binding protein
EXW59_31780	COG1368	sulfuric ester hydrolase activity
EXW59_31790	COG0791	NLP P60 protein
EXW59_31790	COG1388	LysM domain
EXW59_31795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW59_31805	COG1215	transferase activity, transferring glycosyl groups
EXW59_31810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW59_31820	COG3584	3D domain protein
EXW59_31820	COG1388	LysM domain
EXW59_31845	COG4715	Zinc finger, swim domain protein
EXW59_31850	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW59_31890	COG0577	efflux transmembrane transporter activity
EXW59_31895	COG1136	(ABC) transporter
EXW59_31930	COG5002	protein histidine kinase activity
EXW59_31930	COG3850	Histidine kinase
EXW59_31935	COG0745	RESPONSE REGULATOR receiver
EXW59_31945	COG1316	TRANSCRIPTIONal
EXW59_31950	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW59_31955	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW59_31960	COG1215	transferase activity, transferring glycosyl groups
EXW59_31965	COG0438	transferase activity, transferring glycosyl groups
EXW59_31985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW59_31990	COG4464	protein tyrosine phosphatase activity
EXW59_31995	COG0489	protein tyrosine kinase activity
EXW59_32000	COG3944	biosynthesis protein
EXW59_32005	COG0489	protein tyrosine kinase activity
EXW59_32020	COG1609	Transcriptional regulator
EXW59_32030	COG0739	heme binding
EXW59_32045	COG3279	Response regulator of the LytR AlgR family
EXW59_32050	COG2385	sporulation resulting in formation of a cellular spore
EXW59_32065	COG4836	Membrane
EXW59_32070	COG1007	ATP synthesis coupled electron transport
EXW59_32075	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_32080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW59_32085	COG0713	ATP synthesis coupled electron transport
EXW59_32090	COG0839	Belongs to the complex I subunit 6 family
EXW59_32100	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW59_32105	COG0649	NAD binding
EXW59_32110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_32115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_32120	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW59_32125	COG3300	MHYT domain
EXW59_32125	COG5001	Diguanylate cyclase
EXW59_32140	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW59_32145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW59_32150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXW59_32155	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXW59_32160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW59_32165	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW59_32175	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW59_32200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXW59_32210	COG0698	ribose 5-phosphate isomerase
EXW59_32220	COG2190	(PTS) system
EXW59_32225	COG2259	Doxx family
EXW59_32230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW59_32240	COG1971	Probably functions as a manganese efflux pump
EXW59_32245	COG0009	L-threonylcarbamoyladenylate synthase
EXW59_32260	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW59_32265	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW59_32270	COG1435	thymidine kinase activity
EXW59_32280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW59_32290	COG1494	fructose-1,6-bisphosphatase
EXW59_32310	COG4821	SIS domain
EXW59_32315	COG0504	CTP synthase activity
EXW59_32320	COG3343	RNA polymerase activity
EXW59_32330	COG1960	acyl-CoA dehydrogenase activity
EXW59_32335	COG1960	acyl-CoA dehydrogenase activity
EXW59_32340	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW59_32345	COG0183	Belongs to the thiolase family
EXW59_32350	COG0247	lactate metabolic process
EXW59_32350	COG2181	nitrate reductase activity
EXW59_32355	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW59_32360	COG4294	response to UV
EXW59_32365	COG3300	MHYT domain
EXW59_32365	COG5001	Diguanylate cyclase
EXW59_32380	COG3227	Zinc metalloprotease (Elastase)
EXW59_32385	COG2197	response regulator
EXW59_32390	COG4585	Histidine kinase
EXW59_32395	COG0842	Transport permease protein
EXW59_32400	COG1131	(ABC) transporter
EXW59_32405	COG0024	Methionine aminopeptidase
EXW59_32420	COG2234	aminopeptidase activity
EXW59_32435	COG4506	Protein conserved in bacteria
EXW59_32440	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW59_32455	COG0010	Belongs to the arginase family
EXW59_32460	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW59_32465	COG2814	Major facilitator Superfamily
EXW59_32470	COG0789	Transcriptional regulator
EXW59_32475	COG0584	glycerophosphoryl diester phosphodiesterase
EXW59_32480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW59_32490	COG1994	Peptidase M50
EXW59_32500	COG1078	dGTPase activity
EXW59_32505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW59_32510	COG1120	ATPase activity
EXW59_32515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_32520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW59_32525	COG4844	belongs to the
EXW59_32540	COG0280	phosphate acetyltransferase
EXW59_32545	COG3253	May function as heme-dependent peroxidase
EXW59_32555	COG3773	Cell wall hydrolase
EXW59_32565	COG2363	Small membrane protein
EXW59_32580	COG2233	PERMEase
EXW59_32585	COG0561	phosphatase activity
EXW59_32590	COG2814	Major facilitator Superfamily
EXW59_32595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW59_32600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW59_32605	COG1131	(ABC) transporter
EXW59_32610	COG2755	lipolytic protein G-D-S-L family
EXW59_32615	COG1609	Transcriptional regulator
EXW59_32625	COG0460	homoserine dehydrogenase
EXW59_32630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW59_32635	COG2873	o-acetylhomoserine
EXW59_32650	COG2197	response regulator
EXW59_32655	COG4585	Histidine kinase
EXW59_32655	COG2203	Gaf domain
EXW59_32660	COG0351	phosphomethylpyrimidine kinase
EXW59_32665	COG3706	GGDEF domain
EXW59_32670	COG2879	small protein
EXW59_32675	COG1966	Carbon starvation protein
EXW59_32680	COG3279	Response regulator of the LytR AlgR family
EXW59_32685	COG0477	Major facilitator Superfamily
EXW59_32715	COG0840	transmembrane signaling receptor activity
EXW59_32725	COG1607	acyl-coa hydrolase
EXW59_32730	COG1216	Glycosyl transferase, family 2
EXW59_32745	COG1216	Glycosyl transferase, family 2
EXW59_32755	COG0488	(ABC) transporter
EXW59_32760	COG1309	transcriptional regulator
EXW59_32765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW59_32770	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW59_32770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW59_32775	COG0628	permease
EXW59_32785	COG1380	Effector of murein hydrolase LrgA
EXW59_32790	COG3279	Response regulator of the LytR AlgR family
EXW59_32795	COG3275	phosphorelay sensor kinase activity
EXW59_32800	COG2814	Major facilitator Superfamily
EXW59_32805	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW59_32810	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW59_32820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW59_32870	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW59_32875	COG1272	protein, Hemolysin III
EXW59_32900	COG1164	Oligoendopeptidase f
EXW59_32915	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW59_32925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW59_32930	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW59_32935	COG4853	Protein conserved in bacteria
EXW59_32945	COG5002	protein histidine kinase activity
EXW59_32950	COG0745	RESPONSE REGULATOR receiver
EXW59_32980	COG0305	Participates in initiation and elongation during chromosome replication
EXW59_32985	COG0359	binds to the 23S rRNA
EXW59_32990	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW59_32995	COG4241	membrane
EXW59_33005	COG0629	single-stranded DNA binding
EXW59_33010	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW59_33015	COG0012	GTP binding
EXW59_33020	COG4481	Protein conserved in bacteria
EXW59_33025	COG0668	transmembrane transport
EXW59_33035	COG1475	DNA binding
EXW59_33040	COG1192	Involved in chromosome partitioning
EXW59_33045	COG1475	DNA binding
EXW59_33050	COG0357	Ribosomal RNA small subunit methyltransferase G
EXW59_33055	COG0445	tRNA wobble uridine modification
EXW59_33060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW59_33065	COG1847	R3H domain protein
EXW59_33070	COG0706	membrane insertase activity
EXW59_33075	COG0594	ribonuclease P activity
EXW59_33080	COG0230	Belongs to the bacterial ribosomal protein bL34 family