locus-tag	class	description
EXW46_00015	COG1846	Transcriptional regulator
EXW46_00035	COG1968	undecaprenyl-diphosphatase activity
EXW46_00040	COG0534	Mate efflux family protein
EXW46_00065	COG0716	FMN binding
EXW46_00080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW46_00085	COG1696	Membrane protein involved in D-alanine export
EXW46_00090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW46_00095	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW46_00100	COG2070	2-Nitropropane dioxygenase
EXW46_00105	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW46_00115	COG1335	isochorismatase
EXW46_00125	COG1522	sequence-specific DNA binding
EXW46_00135	COG1266	CAAX protease self-immunity
EXW46_00140	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_00145	COG1131	(ABC) transporter
EXW46_00155	COG1131	(ABC) transporter
EXW46_00160	COG1725	Transcriptional regulator
EXW46_00170	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_00175	COG2204	response regulator
EXW46_00195	COG0531	amino acid
EXW46_00200	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXW46_00215	COG1780	Probably involved in ribonucleotide reductase function
EXW46_00235	COG0456	acetyltransferase
EXW46_00245	COG4873	Protein conserved in bacteria
EXW46_00250	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXW46_00260	COG0720	synthase
EXW46_00265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXW46_00270	COG5002	protein histidine kinase activity
EXW46_00275	COG2318	DinB family
EXW46_00285	COG1846	Transcriptional regulator
EXW46_00290	COG3852	Histidine kinase
EXW46_00300	COG2861	carbohydrate metabolic process
EXW46_00310	COG0235	Class ii aldolase
EXW46_00320	COG1349	DNA-binding transcription factor activity
EXW46_00330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW46_00335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW46_00345	COG3842	ATPase activity
EXW46_00350	COG1840	ABC-type Fe3 transport system, periplasmic component
EXW46_00365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW46_00375	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXW46_00380	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_00400	COG2030	dehydratase
EXW46_00410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW46_00415	COG0861	Integral membrane protein TerC family
EXW46_00420	COG2116	formate transmembrane transporter activity
EXW46_00430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
EXW46_00435	COG1556	Lactate utilization protein
EXW46_00440	COG1139	Iron-sulfur cluster binding protein
EXW46_00445	COG0247	lactate metabolic process
EXW46_00450	COG2186	Transcriptional regulator
EXW46_00455	COG3850	Histidine kinase
EXW46_00455	COG5002	protein histidine kinase activity
EXW46_00460	COG0745	RESPONSE REGULATOR receiver
EXW46_00470	COG3835	regulator
EXW46_00475	COG0277	FAD linked oxidase domain protein
EXW46_00480	COG0247	lactate metabolic process
EXW46_00485	COG2340	Cysteine-rich secretory protein family
EXW46_00495	COG0564	pseudouridine synthase activity
EXW46_00505	COG2409	Drug exporters of the RND superfamily
EXW46_00515	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXW46_00520	COG1177	transmembrane transport
EXW46_00525	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXW46_00535	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_00570	COG0681	Belongs to the peptidase S26 family
EXW46_00575	COG1686	Belongs to the peptidase S11 family
EXW46_00620	COG1476	TRANSCRIPTIONal
EXW46_00625	COG0567	Dehydrogenase, E1 component
EXW46_00630	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_00650	COG2226	methyltransferase
EXW46_00710	COG5634	Uncharacterized conserved protein (DUF2278)
EXW46_00715	COG1620	l-lactate permease
EXW46_00725	COG0159	tryptophan synthase activity
EXW46_00730	COG0133	tryptophan synthase activity
EXW46_00735	COG0135	phosphoribosylanthranilate isomerase activity
EXW46_00740	COG0134	indole-3-glycerol-phosphate synthase activity
EXW46_00745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW46_00750	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW46_00750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXW46_00765	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_00770	COG5492	domain, Protein
EXW46_00795	COG2382	esterase
EXW46_00800	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW46_00805	COG2153	protein acetylation
EXW46_00850	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXW46_00865	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EXW46_00885	COG0457	Tetratricopeptide repeat
EXW46_00885	COG0463	Glycosyl transferase, family 2
EXW46_00905	COG1216	Glycosyl transferase, family 2
EXW46_00910	COG0772	Belongs to the SEDS family
EXW46_00915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW46_00925	COG0564	pseudouridine synthase activity
EXW46_00935	COG2357	RelA SpoT domain protein
EXW46_00945	COG4116	CYTH
EXW46_00950	COG2346	COG2346, Truncated hemoglobins
EXW46_00960	COG1164	Oligoendopeptidase f
EXW46_00970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_00975	COG4862	establishment of competence for transformation
EXW46_00980	COG0861	Integral membrane protein TerC family
EXW46_01000	COG4166	transmembrane transport
EXW46_01005	COG0534	Mate efflux family protein
EXW46_01010	COG4608	Belongs to the ABC transporter superfamily
EXW46_01015	COG0444	Belongs to the ABC transporter superfamily
EXW46_01020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_01025	COG0601	transmembrane transport
EXW46_01030	COG4166	transmembrane transport
EXW46_01045	COG0180	Tryptophanyl-tRNA synthetase
EXW46_01060	COG5504	Zn-dependent protease
EXW46_01065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXW46_01070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_01085	COG2267	carboxylic ester hydrolase activity
EXW46_01105	COG0561	phosphatase activity
EXW46_01120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_01130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW46_01165	COG1329	Transcriptional regulator
EXW46_01180	COG2996	Protein conserved in bacteria
EXW46_01185	COG1666	GTP binding
EXW46_01200	COG0004	ammonium transporteR
EXW46_01205	COG0753	catalase activity
EXW46_01220	COG0367	asparagine synthase
EXW46_01245	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW46_01300	COG1074	ATP-dependent DNA helicase activity
EXW46_01305	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EXW46_01315	COG0398	Pfam SNARE associated Golgi protein
EXW46_01325	COG4903	ComK protein
EXW46_01335	COG1278	Cold shock
EXW46_01345	COG2224	Isocitrate lyase
EXW46_01350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXW46_01380	COG0697	spore germination
EXW46_01385	COG0501	Belongs to the peptidase M48B family
EXW46_01405	COG0745	RESPONSE REGULATOR receiver
EXW46_01410	COG2205	protein histidine kinase activity
EXW46_01415	COG3708	Transcriptional regulator
EXW46_01415	COG2207	Transcriptional regulator
EXW46_01420	COG1595	DNA-templated transcription, initiation
EXW46_01445	COG1129	ABC transporter
EXW46_01450	COG1078	dGTPase activity
EXW46_01455	COG1408	metallophosphoesterase
EXW46_01500	COG4208	sulfate ABC transporter
EXW46_01510	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXW46_01525	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_01535	COG0095	Lipoate-protein ligase
EXW46_01540	COG1234	tRNA 3'-trailer cleavage
EXW46_01550	COG1609	Transcriptional regulator
EXW46_01555	COG2378	regulation of single-species biofilm formation
EXW46_01600	COG1511	domain protein
EXW46_01600	COG1511	domain protein
EXW46_01605	COG1309	transcriptional regulator
EXW46_01640	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW46_01645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXW46_01650	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXW46_01655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_01660	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_01665	COG3428	Bacterial PH domain
EXW46_01670	COG3402	PFAM membrane-flanked domain
EXW46_01700	COG3428	Bacterial PH domain
EXW46_01705	COG3402	PFAM membrane-flanked domain
EXW46_01725	COG1556	Lactate utilization protein
EXW46_01730	COG1139	Iron-sulfur cluster binding protein
EXW46_01735	COG0247	lactate metabolic process
EXW46_01750	COG4473	ABC transporter
EXW46_01755	COG1131	(ABC) transporter
EXW46_01760	COG0537	adenosine 5'-monophosphoramidase activity
EXW46_01770	COG1846	Transcriptional regulator
EXW46_01790	COG3973	AAA domain
EXW46_01805	COG1595	DNA-templated transcription, initiation
EXW46_01810	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXW46_01815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXW46_01820	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EXW46_01825	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW46_01830	COG3620	sequence-specific DNA binding
EXW46_01845	COG2267	carboxylic ester hydrolase activity
EXW46_01855	COG0457	Tetratricopeptide repeat
EXW46_01860	COG0346	lactoylglutathione lyase activity
EXW46_01865	COG0346	lactoylglutathione lyase activity
EXW46_01875	COG3481	metal-dependent phosphohydrolase, HD sub domain
EXW46_01880	COG4717	serine-type aminopeptidase activity
EXW46_01885	COG0420	3'-5' exonuclease activity
EXW46_01915	COG2197	response regulator
EXW46_01920	COG4585	Histidine kinase
EXW46_01955	COG0784	Response regulator, receiver
EXW46_01955	COG2205	protein histidine kinase activity
EXW46_01960	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW46_01965	COG2208	phosphoserine phosphatase activity
EXW46_01975	COG1191	sigma factor activity
EXW46_01980	COG2172	sigma factor antagonist activity
EXW46_02000	COG3237	CsbD-like
EXW46_02030	COG1278	Cold shock
EXW46_02045	COG0076	glutamate decarboxylase activity
EXW46_02080	COG1335	isochorismatase
EXW46_02100	COG5444	nuclease activity
EXW46_02170	COG2376	Dihydroxyacetone kinase
EXW46_02185	COG2376	Dihydroxyacetone kinase
EXW46_02205	COG1183	phosphatidylcholine synthase activity
EXW46_02220	COG0640	Transcriptional regulator
EXW46_02225	COG2814	Major facilitator Superfamily
EXW46_02230	COG2732	(Barnase) inhibitor
EXW46_02310	COG0477	Major facilitator Superfamily
EXW46_02340	COG0305	Participates in initiation and elongation during chromosome replication
EXW46_02420	COG3181	Tripartite tricarboxylate transporter family receptor
EXW46_02425	COG4565	transcriptional regulatory protein
EXW46_02430	COG3290	protein histidine kinase activity
EXW46_02435	COG0477	Major facilitator Superfamily
EXW46_02520	COG4608	Belongs to the ABC transporter superfamily
EXW46_02525	COG0444	Belongs to the ABC transporter superfamily
EXW46_02530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_02535	COG0601	transmembrane transport
EXW46_02565	COG0579	oxidoreductase
EXW46_02585	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW46_02590	COG1113	amino acid transport
EXW46_02610	COG1363	Peptidase, m42
EXW46_02625	COG1024	Enoyl-CoA hydratase
EXW46_02640	COG1696	Membrane protein involved in D-alanine export
EXW46_02655	COG4196	transglutaminase domain protein
EXW46_02660	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_02670	COG2244	polysaccharide biosynthetic process
EXW46_02690	COG0659	secondary active sulfate transmembrane transporter activity
EXW46_02700	COG4978	Transcriptional regulator
EXW46_02700	COG0789	Transcriptional regulator
EXW46_02710	COG0586	Pfam SNARE associated Golgi protein
EXW46_02720	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_02725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW46_02730	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW46_02730	COG3409	Peptidoglycan-binding domain 1 protein
EXW46_02735	COG0561	phosphatase activity
EXW46_02740	COG2094	Belongs to the DNA glycosylase MPG family
EXW46_02745	COG1216	Glycosyl transferase, family 2
EXW46_02750	COG0463	Glycosyl transferase, family 2
EXW46_02755	COG3527	Alpha-acetolactate decarboxylase
EXW46_02760	COG0028	Belongs to the TPP enzyme family
EXW46_02775	COG3679	Belongs to the UPF0342 family
EXW46_02780	COG4399	Belongs to the UPF0754 family
EXW46_02790	COG0189	ligase activity
EXW46_02805	COG1126	abc transporter atp-binding protein
EXW46_02810	COG0765	amino acid transport
EXW46_02815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_02820	COG1132	(ABC) transporter
EXW46_02825	COG1132	(ABC) transporter
EXW46_02840	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_02845	COG0531	amino acid
EXW46_02855	COG0693	protein deglycase activity
EXW46_02865	COG2211	Major facilitator Superfamily
EXW46_02870	COG4533	DNA binding
EXW46_02880	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW46_02890	COG1733	regulation of RNA biosynthetic process
EXW46_02895	COG2814	Major facilitator Superfamily
EXW46_02900	COG1309	transcriptional regulator
EXW46_02905	COG2076	Multidrug Resistance protein
EXW46_02930	COG1522	sequence-specific DNA binding
EXW46_02955	COG2259	Doxx family
EXW46_02965	COG1263	PTS System
EXW46_02965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_02970	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXW46_02975	COG1737	Transcriptional regulator
EXW46_02985	COG0475	glutathione-regulated potassium exporter activity
EXW46_02990	COG0531	amino acid
EXW46_03025	COG0586	Pfam SNARE associated Golgi protein
EXW46_03055	COG3546	catalase activity
EXW46_03060	COG1114	Component of the transport system for branched-chain amino acids
EXW46_03075	COG5522	Integral membrane protein (intg_mem_TP0381)
EXW46_03085	COG1136	(ABC) transporter
EXW46_03090	COG0577	efflux transmembrane transporter activity
EXW46_03095	COG1388	LysM domain
EXW46_03095	COG3584	3D domain protein
EXW46_03120	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_03125	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_03130	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_03130	COG3711	transcriptional antiterminator
EXW46_03145	COG2814	Major facilitator Superfamily
EXW46_03155	COG1283	sodium-dependent phosphate transmembrane transporter activity
EXW46_03160	COG0604	alcohol dehydrogenase
EXW46_03165	COG1316	TRANSCRIPTIONal
EXW46_03175	COG0730	response to heat
EXW46_03180	COG2210	Belongs to the sulfur carrier protein TusA family
EXW46_03185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_03185	COG0425	Belongs to the sulfur carrier protein TusA family
EXW46_03190	COG0425	Belongs to the sulfur carrier protein TusA family
EXW46_03195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_03195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_03200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_03200	COG0425	Belongs to the sulfur carrier protein TusA family
EXW46_03205	COG1937	Protein conserved in bacteria
EXW46_03240	COG2719	SpoVR family
EXW46_03245	COG0778	Nitroreductase
EXW46_03280	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXW46_03305	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_03310	COG2252	PERMEase
EXW46_03320	COG1846	Transcriptional regulator
EXW46_03325	COG2814	Major facilitator Superfamily
EXW46_03330	COG2205	protein histidine kinase activity
EXW46_03335	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXW46_03340	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXW46_03370	COG0351	phosphomethylpyrimidine kinase
EXW46_03375	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_03385	COG2104	thiamine diphosphate biosynthetic process
EXW46_03390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_03395	COG0352	thiamine-phosphate diphosphorylase activity
EXW46_03400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW46_03405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW46_03410	COG1116	anion transmembrane transporter activity
EXW46_03415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW46_03420	COG4991	sh3 domain protein
EXW46_03420	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_03420	COG3103	Sh3 type 3 domain protein
EXW46_03435	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EXW46_03555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW46_03565	COG0581	inorganic phosphate transmembrane transporter activity
EXW46_03570	COG0573	inorganic phosphate transmembrane transporter activity
EXW46_03575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW46_03585	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW46_03590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
EXW46_03600	COG0531	amino acid
EXW46_03605	COG0697	spore germination
EXW46_03610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_03625	COG4990	cell redox homeostasis
EXW46_03630	COG0833	amino acid
EXW46_03640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EXW46_03645	COG1845	cytochrome c oxidase, subunit III
EXW46_03660	COG0475	glutathione-regulated potassium exporter activity
EXW46_03660	COG0569	domain protein
EXW46_03670	COG2153	protein acetylation
EXW46_03685	COG2252	PERMEase
EXW46_03690	COG1113	amino acid transport
EXW46_03705	COG1114	Component of the transport system for branched-chain amino acids
EXW46_03710	COG3104	oligopeptide transport
EXW46_03730	COG1476	TRANSCRIPTIONal
EXW46_03735	COG3583	domain protein
EXW46_03735	COG3584	3D domain protein
EXW46_03740	COG0840	transmembrane signaling receptor activity
EXW46_03785	COG1063	alcohol dehydrogenase
EXW46_03815	COG1879	ABC-type sugar transport system periplasmic component
EXW46_03820	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXW46_03830	COG1869	D-ribose catabolic process
EXW46_03835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXW46_03840	COG1609	Transcriptional regulator
EXW46_03845	COG0477	Major facilitator Superfamily
EXW46_03850	COG1846	Transcriptional regulator
EXW46_03855	COG2271	Major facilitator Superfamily
EXW46_03870	COG0659	secondary active sulfate transmembrane transporter activity
EXW46_03885	COG5002	protein histidine kinase activity
EXW46_03890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EXW46_03895	COG2378	regulation of single-species biofilm formation
EXW46_03925	COG0833	amino acid
EXW46_03930	COG0765	amino acid transport
EXW46_03935	COG0765	amino acid transport
EXW46_03940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_03945	COG1126	abc transporter atp-binding protein
EXW46_03950	COG1115	amino acid carrier protein
EXW46_03955	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW46_03970	COG1404	Belongs to the peptidase S8 family
EXW46_03980	COG4585	Histidine kinase
EXW46_03985	COG0697	spore germination
EXW46_04000	COG0366	Alpha amylase catalytic
EXW46_04005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_04005	COG1263	PTS System
EXW46_04010	COG2188	Transcriptional regulator
EXW46_04015	COG0531	amino acid
EXW46_04035	COG0714	Associated with various cellular activities
EXW46_04040	COG4548	von Willebrand factor, type A
EXW46_04050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW46_04055	COG0156	8-amino-7-oxononanoate synthase activity
EXW46_04060	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW46_04070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_04075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_04080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_04085	COG3104	oligopeptide transport
EXW46_04105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_04110	COG1620	l-lactate permease
EXW46_04115	COG1027	Aspartate ammonia-lyase
EXW46_04120	COG1253	flavin adenine dinucleotide binding
EXW46_04125	COG0346	lactoylglutathione lyase activity
EXW46_04130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_04135	COG1316	TRANSCRIPTIONal
EXW46_04140	COG2720	vancomycin resistance protein
EXW46_04160	COG3227	Zinc metalloprotease (Elastase)
EXW46_04170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXW46_04175	COG2217	Heavy metal translocating P-type atpase
EXW46_04180	COG0640	Transcriptional regulator
EXW46_04190	COG0531	amino acid
EXW46_04205	COG2427	Protein of unknown function (DUF1641)
EXW46_04210	COG3383	formate dehydrogenase (NAD+) activity
EXW46_04215	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW46_04220	COG0456	acetyltransferase
EXW46_04225	COG0745	RESPONSE REGULATOR receiver
EXW46_04230	COG5002	protein histidine kinase activity
EXW46_04240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_04245	COG0697	spore germination
EXW46_04255	COG0281	malic enzyme
EXW46_04260	COG3493	citrate carrier protein
EXW46_04265	COG4565	transcriptional regulatory protein
EXW46_04270	COG3290	protein histidine kinase activity
EXW46_04280	COG4990	cell redox homeostasis
EXW46_04290	COG5002	protein histidine kinase activity
EXW46_04295	COG0745	RESPONSE REGULATOR receiver
EXW46_04300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXW46_04310	COG0395	ABC-type sugar transport system, permease component
EXW46_04315	COG1175	transmembrane transport
EXW46_04320	COG3842	ATPase activity
EXW46_04325	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
EXW46_04350	COG2851	Citrate transporter
EXW46_04355	COG4565	transcriptional regulatory protein
EXW46_04360	COG3290	protein histidine kinase activity
EXW46_04370	COG2268	Band 7 protein
EXW46_04375	COG1585	Membrane protein implicated in regulation of membrane protease activity
EXW46_04390	COG2718	Belongs to the UPF0229 family
EXW46_04395	COG2766	serine protein kinase
EXW46_04400	COG1716	ATPase activity
EXW46_04400	COG5001	Diguanylate cyclase
EXW46_04405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXW46_04425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXW46_04430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EXW46_04550	COG0735	belongs to the Fur family
EXW46_04555	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXW46_04575	COG4555	ABC transporter
EXW46_04580	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW46_04585	COG0070	glutamate synthase
EXW46_04585	COG0069	glutamate synthase activity
EXW46_04585	COG0067	glutamate synthase
EXW46_04595	COG4129	membrane
EXW46_04600	COG1132	(ABC) transporter
EXW46_04605	COG3557	Belongs to the UPF0374 family
EXW46_04620	COG1194	a g-specific adenine glycosylase
EXW46_04625	COG1988	membrane-bound metal-dependent
EXW46_04650	COG2137	regulation of response to DNA damage stimulus
EXW46_04655	COG1090	epimerase
EXW46_04660	COG1228	amidohydrolase
EXW46_04675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXW46_04680	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
EXW46_04695	COG0463	Glycosyl transferase, family 2
EXW46_04700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW46_04700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW46_04710	COG1216	Glycosyl transferase, family 2
EXW46_04725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_04730	COG1263	PTS System
EXW46_04730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_04740	COG2066	Belongs to the glutaminase family
EXW46_04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW46_04765	COG0833	amino acid
EXW46_04775	COG3829	transcription factor binding
EXW46_04795	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW46_04815	COG0535	radical SAM domain protein
EXW46_04825	COG0387	Pfam Sodium calcium exchanger
EXW46_04830	COG3871	stress protein (general stress protein 26)
EXW46_04845	COG0586	Pfam SNARE associated Golgi protein
EXW46_04865	COG0697	spore germination
EXW46_04870	COG2217	Heavy metal translocating P-type atpase
EXW46_04875	COG1295	ribonuclease BN
EXW46_04885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXW46_04890	COG4840	Belongs to the UPF0435 family
EXW46_04900	COG3853	Toxic anion resistance protein (TelA)
EXW46_04910	COG0861	Integral membrane protein TerC family
EXW46_04915	COG2310	stress, protein
EXW46_04920	COG2310	stress, protein
EXW46_04925	COG2310	stress, protein
EXW46_04955	COG2270	Major facilitator Superfamily
EXW46_05000	COG0488	(ABC) transporter
EXW46_05005	COG1116	anion transmembrane transporter activity
EXW46_05010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW46_05015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW46_05030	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EXW46_05035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW46_05040	COG0352	thiamine-phosphate diphosphorylase activity
EXW46_05045	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EXW46_05065	COG2190	(PTS) system
EXW46_05065	COG1263	PTS System
EXW46_05065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_05070	COG0366	Alpha amylase catalytic
EXW46_05075	COG0277	FAD linked oxidase domain protein
EXW46_05090	COG0549	Belongs to the carbamate kinase family
EXW46_05115	COG0840	transmembrane signaling receptor activity
EXW46_05125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_05130	COG0765	amino acid transport
EXW46_05140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_05140	COG0723	plastoquinol--plastocyanin reductase activity
EXW46_05145	COG2814	Major facilitator Superfamily
EXW46_05150	COG3541	Predicted nucleotidyltransferase
EXW46_05170	COG5002	protein histidine kinase activity
EXW46_05195	COG0166	Belongs to the GPI family
EXW46_05210	COG0492	ferredoxin-NADP+ reductase activity
EXW46_05220	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_05225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_05230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_05240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW46_05250	COG0450	alkyl hydroperoxide reductase
EXW46_05270	COG1473	amidohydrolase
EXW46_05275	COG1757	Na H antiporter
EXW46_05300	COG4807	Protein conserved in bacteria
EXW46_05305	COG5002	protein histidine kinase activity
EXW46_05310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW46_05320	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_05335	COG2309	aminopeptidase activity
EXW46_05340	COG2076	Multidrug Resistance protein
EXW46_05345	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_05350	COG0531	amino acid
EXW46_05360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXW46_05365	COG0546	phosphoglycolate phosphatase activity
EXW46_05370	COG1597	lipid kinase activity
EXW46_05375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXW46_05380	COG0154	amidase activity
EXW46_05390	COG4682	membrane
EXW46_05395	COG1846	Transcriptional regulator
EXW46_05400	COG0003	Pfam Anion-transporting ATPase
EXW46_05415	COG1464	Belongs to the NlpA lipoprotein family
EXW46_05420	COG2011	ABC-type metal ion transport system permease component
EXW46_05430	COG1335	isochorismatase
EXW46_05435	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_05445	COG4851	CamS sex pheromone cAM373 precursor
EXW46_05450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXW46_05455	COG0210	DNA helicase
EXW46_05460	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
EXW46_05480	COG0151	Belongs to the GarS family
EXW46_05485	COG0138	bifunctional purine biosynthesis protein purh
EXW46_05490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXW46_05495	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXW46_05500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EXW46_05505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW46_05510	COG0047	phosphoribosylformylglycinamidine synthase activity
EXW46_05515	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXW46_05520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXW46_05525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EXW46_05530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXW46_05535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXW46_05565	COG0697	spore germination
EXW46_05585	COG0745	RESPONSE REGULATOR receiver
EXW46_05590	COG2205	protein histidine kinase activity
EXW46_05630	COG1215	transferase activity, transferring glycosyl groups
EXW46_05640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXW46_05650	COG2226	methyltransferase
EXW46_05680	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW46_05705	COG5002	protein histidine kinase activity
EXW46_05715	COG2252	PERMEase
EXW46_05720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXW46_05720	COG0519	Catalyzes the synthesis of GMP from XMP
EXW46_05725	COG0459	protein refolding
EXW46_05730	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXW46_05735	COG1266	CAAX protease self-immunity
EXW46_05745	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EXW46_05750	COG0488	(ABC) transporter
EXW46_05760	COG0456	acetyltransferase
EXW46_05765	COG1214	PFAM Peptidase M22, glycoprotease
EXW46_05770	COG0802	atpase or kinase
EXW46_05870	COG2183	response to ionizing radiation
EXW46_05875	COG2337	Toxic component of a toxin-antitoxin (TA) module
EXW46_05880	COG0864	Transcriptional regulator
EXW46_05890	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXW46_05895	COG0736	holo-[acyl-carrier-protein] synthase activity
EXW46_05900	COG0705	Rhomboid family
EXW46_05905	COG4294	response to UV
EXW46_05915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
EXW46_05925	COG2814	Major facilitator Superfamily
EXW46_05935	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW46_05940	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EXW46_05970	COG0561	phosphatase activity
EXW46_05975	COG4608	Belongs to the ABC transporter superfamily
EXW46_05980	COG0444	Belongs to the ABC transporter superfamily
EXW46_05985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_05990	COG0601	transmembrane transport
EXW46_06000	COG0747	negative chemotaxis
EXW46_06010	COG0842	Transport permease protein
EXW46_06015	COG0842	Transport permease protein
EXW46_06015	COG1511	domain protein
EXW46_06020	COG1131	(ABC) transporter
EXW46_06025	COG2197	response regulator
EXW46_06030	COG4585	Histidine kinase
EXW46_06035	COG0488	(ABC) transporter
EXW46_06060	COG5298	Protein conserved in bacteria
EXW46_06075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_06085	COG1609	Transcriptional regulator
EXW46_06095	COG0204	Acyl-transferase
EXW46_06110	COG0697	spore germination
EXW46_06125	COG1910	domain protein
EXW46_06130	COG0725	ABC transporter, periplasmic molybdate-binding protein
EXW46_06135	COG4149	molybdate abc transporter
EXW46_06145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_06150	COG0656	L-ascorbic acid biosynthetic process
EXW46_06155	COG4166	transmembrane transport
EXW46_06160	COG4166	transmembrane transport
EXW46_06175	COG2207	Transcriptional regulator
EXW46_06185	COG4166	transmembrane transport
EXW46_06190	COG4608	Belongs to the ABC transporter superfamily
EXW46_06195	COG0444	Belongs to the ABC transporter superfamily
EXW46_06200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXW46_06205	COG0601	transmembrane transport
EXW46_06225	COG2814	Major facilitator Superfamily
EXW46_06235	COG2271	Major facilitator Superfamily
EXW46_06240	COG0277	FAD linked oxidase domain protein
EXW46_06250	COG0604	alcohol dehydrogenase
EXW46_06255	COG1464	Belongs to the NlpA lipoprotein family
EXW46_06265	COG2011	ABC-type metal ion transport system permease component
EXW46_06270	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_06280	COG1506	peptidase
EXW46_06280	COG4946	Tricorn protease homolog
EXW46_06280	COG0823	Involved in the tonB-independent uptake of proteins
EXW46_06300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW46_06305	COG4856	YbbR-like protein
EXW46_06310	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
EXW46_06390	COG0726	polysaccharide deacetylase
EXW46_06395	COG2194	sulfuric ester hydrolase activity
EXW46_06405	COG0489	protein tyrosine kinase activity
EXW46_06410	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_06420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXW46_06425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXW46_06435	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EXW46_06460	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXW46_06465	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXW46_06470	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXW46_06480	COG0024	Methionine aminopeptidase
EXW46_06485	COG0563	adenylate kinase activity
EXW46_06490	COG0201	protein transport
EXW46_06495	COG0200	Binds to the 23S rRNA
EXW46_06500	COG1841	ribosomal large subunit assembly
EXW46_06510	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXW46_06520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXW46_06530	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXW46_06535	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXW46_06545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXW46_06550	COG0255	Belongs to the universal ribosomal protein uL29 family
EXW46_06565	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXW46_06570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXW46_06575	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXW46_06580	COG0089	rRNA binding
EXW46_06585	COG0088	Forms part of the polypeptide exit tunnel
EXW46_06590	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXW46_06595	COG0051	transcription antitermination factor activity, RNA binding
EXW46_06600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXW46_06605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXW46_06615	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXW46_06620	COG1358	cellular component organization or biogenesis
EXW46_06625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXW46_06630	COG0085	RNA polymerase activity
EXW46_06635	COG2813	Specifically methylates the guanine in position
EXW46_06640	COG0222	ribosome binding
EXW46_06645	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXW46_06650	COG0081	regulation of translation
EXW46_06655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXW46_06660	COG0250	Participates in transcription elongation, termination and antitermination
EXW46_06665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW46_06670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW46_06680	COG3688	RNA-binding protein containing a PIN domain
EXW46_06685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW46_06695	COG0215	cysteine-tRNA ligase activity
EXW46_06700	COG1045	serine acetyltransferase
EXW46_06705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXW46_06715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXW46_06720	COG4956	integral membrane protein (PIN domain superfamily)
EXW46_06725	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EXW46_06730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EXW46_06735	COG0542	response to heat
EXW46_06740	COG3869	Catalyzes the specific phosphorylation of arginine residues in
EXW46_06745	COG3880	PFAM UvrB UvrC protein
EXW46_06830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXW46_06835	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXW46_06840	COG1396	sequence-specific DNA binding
EXW46_06845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXW46_06850	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EXW46_06855	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EXW46_06860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW46_06865	COG0512	Glutamine amidotransferase of anthranilate synthase
EXW46_06870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EXW46_06875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW46_06880	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXW46_06885	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXW46_06890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXW46_06895	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW46_06905	COG2208	phosphoserine phosphatase activity
EXW46_06920	COG1098	S1 RNA binding domain
EXW46_06940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXW46_06945	COG3956	TIGRFAM MazG family protein
EXW46_06950	COG2244	polysaccharide biosynthetic process
EXW46_06955	COG2002	toxin-antitoxin pair type II binding
EXW46_06960	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXW46_06980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXW46_06985	COG2088	sporulation resulting in formation of a cellular spore
EXW46_06990	COG0251	oxidation-reduction process
EXW46_06995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW46_07000	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXW46_07010	COG4466	Protein conserved in bacteria
EXW46_07020	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXW46_07030	COG0084	hydrolase, TatD family'
EXW46_07040	COG2002	toxin-antitoxin pair type II binding
EXW46_07045	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXW46_07055	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EXW46_07060	COG4467	Involved in initiation control of chromosome replication
EXW46_07065	COG1774	PSP1 C-terminal conserved region
EXW46_07070	COG0470	DNA polymerase III
EXW46_07075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXW46_07080	COG1982	Orn Lys Arg decarboxylase major
EXW46_07125	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXW46_07130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXW46_07135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EXW46_07145	COG0590	tRNA wobble adenosine to inosine editing
EXW46_07150	COG1335	isochorismatase
EXW46_07155	COG1428	Deoxynucleoside kinase
EXW46_07160	COG1428	Deoxynucleoside kinase
EXW46_07180	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
EXW46_07185	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EXW46_07190	COG1686	Belongs to the peptidase S11 family
EXW46_07195	COG0516	GMP reductase activity
EXW46_07195	COG0517	IMP dehydrogenase activity
EXW46_07230	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW46_07235	COG0187	DNA topoisomerase II activity
EXW46_07240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW46_07245	COG2501	S4 domain
EXW46_07250	COG0592	DNA-directed DNA polymerase activity
EXW46_07255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXW46_07260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXW46_07265	COG0594	ribonuclease P activity
EXW46_07270	COG0706	membrane insertase activity
EXW46_07275	COG1847	R3H domain protein
EXW46_07280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXW46_07285	COG0445	tRNA wobble uridine modification
EXW46_07295	COG1475	DNA binding
EXW46_07300	COG1192	Involved in chromosome partitioning
EXW46_07305	COG1475	DNA binding
EXW46_07315	COG0668	transmembrane transport
EXW46_07320	COG4481	Protein conserved in bacteria
EXW46_07325	COG0012	GTP binding
EXW46_07330	COG0360	Binds together with S18 to 16S ribosomal RNA
EXW46_07335	COG0629	single-stranded DNA binding
EXW46_07345	COG4241	membrane
EXW46_07350	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
EXW46_07355	COG0359	binds to the 23S rRNA
EXW46_07360	COG0305	Participates in initiation and elongation during chromosome replication
EXW46_07390	COG0745	RESPONSE REGULATOR receiver
EXW46_07395	COG5002	protein histidine kinase activity
EXW46_07405	COG4853	Protein conserved in bacteria
EXW46_07410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EXW46_07415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW46_07425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXW46_07435	COG1164	Oligoendopeptidase f
EXW46_07465	COG1272	protein, Hemolysin III
EXW46_07470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW46_07520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW46_07530	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
EXW46_07535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW46_07540	COG2814	Major facilitator Superfamily
EXW46_07545	COG3275	phosphorelay sensor kinase activity
EXW46_07550	COG3279	Response regulator of the LytR AlgR family
EXW46_07555	COG1380	Effector of murein hydrolase LrgA
EXW46_07565	COG0628	permease
EXW46_07570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW46_07570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW46_07575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXW46_07580	COG1309	transcriptional regulator
EXW46_07585	COG0488	(ABC) transporter
EXW46_07595	COG1216	Glycosyl transferase, family 2
EXW46_07610	COG1216	Glycosyl transferase, family 2
EXW46_07615	COG1607	acyl-coa hydrolase
EXW46_07625	COG0840	transmembrane signaling receptor activity
EXW46_07655	COG0477	Major facilitator Superfamily
EXW46_07660	COG3279	Response regulator of the LytR AlgR family
EXW46_07665	COG1966	Carbon starvation protein
EXW46_07670	COG2879	small protein
EXW46_07675	COG3706	GGDEF domain
EXW46_07680	COG0351	phosphomethylpyrimidine kinase
EXW46_07685	COG4585	Histidine kinase
EXW46_07685	COG2203	Gaf domain
EXW46_07690	COG2197	response regulator
EXW46_07700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW46_07705	COG1011	Hydrolase
EXW46_07715	COG2873	o-acetylhomoserine
EXW46_07720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
EXW46_07725	COG0460	homoserine dehydrogenase
EXW46_07735	COG1609	Transcriptional regulator
EXW46_07740	COG2755	lipolytic protein G-D-S-L family
EXW46_07745	COG1131	(ABC) transporter
EXW46_07750	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_07755	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EXW46_07760	COG2814	Major facilitator Superfamily
EXW46_07765	COG0561	phosphatase activity
EXW46_07770	COG2233	PERMEase
EXW46_07785	COG2363	Small membrane protein
EXW46_07795	COG3773	Cell wall hydrolase
EXW46_07805	COG3253	May function as heme-dependent peroxidase
EXW46_07810	COG0280	phosphate acetyltransferase
EXW46_07825	COG4844	belongs to the
EXW46_07830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_07835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_07840	COG1120	ATPase activity
EXW46_07845	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_07850	COG1078	dGTPase activity
EXW46_07860	COG1994	Peptidase M50
EXW46_07870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_07875	COG0584	glycerophosphoryl diester phosphodiesterase
EXW46_07880	COG0789	Transcriptional regulator
EXW46_07885	COG2814	Major facilitator Superfamily
EXW46_07890	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXW46_07895	COG0010	Belongs to the arginase family
EXW46_07915	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW46_07920	COG4506	Protein conserved in bacteria
EXW46_07940	COG2234	aminopeptidase activity
EXW46_07945	COG0024	Methionine aminopeptidase
EXW46_07950	COG1131	(ABC) transporter
EXW46_07955	COG0842	Transport permease protein
EXW46_07960	COG4585	Histidine kinase
EXW46_07965	COG2197	response regulator
EXW46_07970	COG3227	Zinc metalloprotease (Elastase)
EXW46_07985	COG5001	Diguanylate cyclase
EXW46_07985	COG3300	MHYT domain
EXW46_07990	COG4294	response to UV
EXW46_07995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_08000	COG0247	lactate metabolic process
EXW46_08000	COG2181	nitrate reductase activity
EXW46_08005	COG0183	Belongs to the thiolase family
EXW46_08010	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW46_08015	COG1960	acyl-CoA dehydrogenase activity
EXW46_08020	COG1960	acyl-CoA dehydrogenase activity
EXW46_08030	COG3343	RNA polymerase activity
EXW46_08035	COG0504	CTP synthase activity
EXW46_08040	COG4821	SIS domain
EXW46_08060	COG1494	fructose-1,6-bisphosphatase
EXW46_08065	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXW46_08075	COG1435	thymidine kinase activity
EXW46_08080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXW46_08085	COG2890	protein-(glutamine-N5) methyltransferase activity
EXW46_08100	COG0009	L-threonylcarbamoyladenylate synthase
EXW46_08105	COG1971	Probably functions as a manganese efflux pump
EXW46_08125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW46_08130	COG2259	Doxx family
EXW46_08135	COG2190	(PTS) system
EXW46_08145	COG0698	ribose 5-phosphate isomerase
EXW46_08180	COG0356	it plays a direct role in the translocation of protons across the membrane
EXW46_08190	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXW46_08195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXW46_08210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXW46_08215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXW46_08235	COG3300	MHYT domain
EXW46_08235	COG5001	Diguanylate cyclase
EXW46_08240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_08245	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_08250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_08255	COG0649	NAD binding
EXW46_08260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXW46_08270	COG0839	Belongs to the complex I subunit 6 family
EXW46_08275	COG0713	ATP synthesis coupled electron transport
EXW46_08280	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXW46_08285	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXW46_08290	COG1007	ATP synthesis coupled electron transport
EXW46_08295	COG4836	Membrane
EXW46_08310	COG2385	sporulation resulting in formation of a cellular spore
EXW46_08315	COG3279	Response regulator of the LytR AlgR family
EXW46_08330	COG0739	heme binding
EXW46_08340	COG1609	Transcriptional regulator
EXW46_08355	COG0489	protein tyrosine kinase activity
EXW46_08360	COG3944	biosynthesis protein
EXW46_08365	COG0489	protein tyrosine kinase activity
EXW46_08370	COG4464	protein tyrosine phosphatase activity
EXW46_08375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW46_08395	COG0438	transferase activity, transferring glycosyl groups
EXW46_08400	COG1215	transferase activity, transferring glycosyl groups
EXW46_08405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW46_08410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXW46_08415	COG1316	TRANSCRIPTIONal
EXW46_08425	COG0745	RESPONSE REGULATOR receiver
EXW46_08430	COG3850	Histidine kinase
EXW46_08430	COG5002	protein histidine kinase activity
EXW46_08445	COG2271	Major facilitator Superfamily
EXW46_08465	COG1136	(ABC) transporter
EXW46_08470	COG0577	efflux transmembrane transporter activity
EXW46_08510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW46_08515	COG4715	Zinc finger, swim domain protein
EXW46_08525	COG1388	LysM domain
EXW46_08525	COG3584	3D domain protein
EXW46_08535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EXW46_08540	COG1215	transferase activity, transferring glycosyl groups
EXW46_08550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_08555	COG1388	LysM domain
EXW46_08555	COG0791	NLP P60 protein
EXW46_08565	COG1368	sulfuric ester hydrolase activity
EXW46_08580	COG2389	metal-binding protein
EXW46_08590	COG1620	l-lactate permease
EXW46_08595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXW46_08600	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW46_08605	COG1294	oxidase, subunit
EXW46_08610	COG1271	oxidase subunit
EXW46_08615	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
EXW46_08620	COG0583	DNA-binding transcription factor activity
EXW46_08625	COG1511	domain protein
EXW46_08655	COG1301	dicarboxylic acid transport
EXW46_08660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_08670	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_08685	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_08690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_08695	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_08700	COG1486	melibiose metabolic process
EXW46_08735	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
EXW46_08735	COG3933	PFAM sigma-54 factor interaction domain-containing protein
EXW46_08745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW46_08750	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EXW46_08755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
EXW46_08760	COG1316	TRANSCRIPTIONal
EXW46_08765	COG1739	Uncharacterized protein family UPF0029
EXW46_08770	COG1307	EDD domain protein, DegV family
EXW46_08775	COG1733	regulation of RNA biosynthetic process
EXW46_08780	COG1388	LysM domain
EXW46_08780	COG0791	NLP P60 protein
EXW46_08785	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
EXW46_08790	COG1040	competence protein
EXW46_08795	COG1278	Cold shock
EXW46_08825	COG1131	(ABC) transporter
EXW46_08860	COG2884	Cell division ATP-binding protein ftsE
EXW46_08865	COG2177	Part of the ABC transporter FtsEX involved in
EXW46_08870	COG0793	Belongs to the peptidase S41A family
EXW46_08870	COG3409	Peptidoglycan-binding domain 1 protein
EXW46_08875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW46_08880	COG1132	(ABC) transporter
EXW46_08890	COG0488	(ABC) transporter
EXW46_08895	COG0655	NAD(P)H dehydrogenase (quinone) activity
EXW46_08900	COG0789	Transcriptional regulator
EXW46_08905	COG0583	DNA-binding transcription factor activity
EXW46_08940	COG0789	Transcriptional regulator
EXW46_08960	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW46_08970	COG1950	PFAM Membrane protein of
EXW46_08975	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXW46_08980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXW46_08985	COG0546	phosphoglycolate phosphatase activity
EXW46_08990	COG0110	maltose O-acetyltransferase activity
EXW46_08995	COG0457	Tetratricopeptide repeat
EXW46_09000	COG0492	ferredoxin-NADP+ reductase activity
EXW46_09010	COG1051	belongs to the nudix hydrolase family
EXW46_09015	COG1660	Displays ATPase and GTPase activities
EXW46_09020	COG0391	Required for morphogenesis under gluconeogenic growth conditions
EXW46_09025	COG1481	regulation of sporulation
EXW46_09030	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_09040	COG2323	membrane
EXW46_09055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_09080	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXW46_09095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW46_09100	COG0126	phosphoglycerate kinase activity
EXW46_09105	COG0149	triose-phosphate isomerase activity
EXW46_09115	COG0148	phosphopyruvate hydratase activity
EXW46_09130	COG1346	cytolysis
EXW46_09135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
EXW46_09140	COG1647	Serine aminopeptidase, S33
EXW46_09145	COG0557	exoribonuclease II activity
EXW46_09155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXW46_09200	COG2233	PERMEase
EXW46_09205	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
EXW46_09210	COG0288	reversible hydration of carbon dioxide
EXW46_09215	COG1522	sequence-specific DNA binding
EXW46_09235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_09270	COG0840	transmembrane signaling receptor activity
EXW46_09270	COG3290	protein histidine kinase activity
EXW46_09305	COG1252	NADH dehydrogenase
EXW46_09315	COG1733	regulation of RNA biosynthetic process
EXW46_09320	COG2814	Major facilitator Superfamily
EXW46_09325	COG0656	L-ascorbic acid biosynthetic process
EXW46_09335	COG2910	NAD(P)H-binding
EXW46_09340	COG1115	amino acid carrier protein
EXW46_09345	COG1115	amino acid carrier protein
EXW46_09350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_09355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_09365	COG2311	Membrane
EXW46_09370	COG1528	Iron-storage protein
EXW46_09380	COG1611	Belongs to the LOG family
EXW46_09385	COG2318	DinB family
EXW46_09395	COG0783	Belongs to the Dps family
EXW46_09400	COG1115	amino acid carrier protein
EXW46_09405	COG0490	domain, Protein
EXW46_09410	COG0475	glutathione-regulated potassium exporter activity
EXW46_09425	COG1741	Belongs to the pirin family
EXW46_09430	COG3227	Zinc metalloprotease (Elastase)
EXW46_09435	COG2151	metal-sulfur cluster biosynthetic enzyme
EXW46_09440	COG0840	transmembrane signaling receptor activity
EXW46_09445	COG0840	transmembrane signaling receptor activity
EXW46_09455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW46_09465	COG5002	protein histidine kinase activity
EXW46_09470	COG0745	RESPONSE REGULATOR receiver
EXW46_09475	COG1376	ErfK ybiS ycfS ynhG family protein
EXW46_09485	COG0586	Pfam SNARE associated Golgi protein
EXW46_09620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_09645	COG0531	amino acid
EXW46_09650	COG2814	Major facilitator Superfamily
EXW46_09665	COG0840	transmembrane signaling receptor activity
EXW46_09670	COG0011	TIGRFAM Protein of
EXW46_09680	COG0506	proline dehydrogenase activity
EXW46_09685	COG1686	Belongs to the peptidase S11 family
EXW46_09695	COG1024	Enoyl-CoA hydratase
EXW46_09695	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW46_09700	COG0183	Belongs to the thiolase family
EXW46_09705	COG1960	acyl-CoA dehydrogenase activity
EXW46_09710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_09715	COG1309	transcriptional regulator
EXW46_09750	COG1393	Belongs to the ArsC family
EXW46_09755	COG0509	glycine decarboxylation via glycine cleavage system
EXW46_09760	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
EXW46_09765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_09775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXW46_09780	COG2011	ABC-type metal ion transport system permease component
EXW46_09785	COG1464	Belongs to the NlpA lipoprotein family
EXW46_09790	COG1464	Belongs to the NlpA lipoprotein family
EXW46_09795	COG0396	ATPase activity
EXW46_09800	COG0719	Fe-S assembly protein
EXW46_09805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EXW46_09810	COG0822	iron-sulfur transferase activity
EXW46_09815	COG0719	Fe-S assembly protein
EXW46_09825	COG0737	Belongs to the 5'-nucleotidase family
EXW46_09830	COG3377	Domain of unknown function (DUF1805)
EXW46_09840	COG0739	heme binding
EXW46_09845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXW46_09865	COG4377	Putative membrane peptidase family (DUF2324)
EXW46_09870	COG0789	Transcriptional regulator
EXW46_09880	COG4470	Protein conserved in bacteria
EXW46_09895	COG1494	fructose-1,6-bisphosphatase
EXW46_09900	COG2445	Protein of unknown function DUF86
EXW46_09910	COG0647	UMP catabolic process
EXW46_09920	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXW46_09925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXW46_09935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EXW46_09940	COG4837	Protein of unknown function (DUF1462)
EXW46_09985	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW46_09990	COG0390	transport system, permease component
EXW46_10000	COG1252	NADH dehydrogenase
EXW46_10005	COG4844	belongs to the
EXW46_10010	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXW46_10015	COG0316	Belongs to the HesB IscA family
EXW46_10035	COG1683	Conserved Protein
EXW46_10050	COG3708	Transcriptional regulator
EXW46_10055	COG0492	ferredoxin-NADP+ reductase activity
EXW46_10060	COG1252	NADH dehydrogenase
EXW46_10075	COG3584	3D domain protein
EXW46_10080	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXW46_10090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXW46_10095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EXW46_10100	COG1268	BioY protein
EXW46_10110	COG2050	protein possibly involved in aromatic compounds catabolism
EXW46_10130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW46_10135	COG5018	Exonuclease
EXW46_10150	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EXW46_10160	COG2267	carboxylic ester hydrolase activity
EXW46_10165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW46_10170	COG1522	sequence-specific DNA binding
EXW46_10175	COG0436	Aminotransferase
EXW46_10180	COG1098	S1 RNA binding domain
EXW46_10185	COG2155	Conserved Protein
EXW46_10195	COG0166	Belongs to the GPI family
EXW46_10205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EXW46_10210	COG1285	pathogenesis
EXW46_10355	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EXW46_10360	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW46_10365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EXW46_10375	COG0058	SHG alpha-glucan phosphorylase activity
EXW46_10400	COG1278	Cold shock
EXW46_10405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
EXW46_10410	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW46_10415	COG1169	isochorismate synthase
EXW46_10420	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EXW46_10425	COG0596	Alpha beta hydrolase
EXW46_10430	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EXW46_10435	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_10440	COG4948	Mandelate Racemase Muconate Lactonizing
EXW46_10465	COG3964	amidohydrolase
EXW46_10485	COG2188	Transcriptional regulator
EXW46_10500	COG0577	efflux transmembrane transporter activity
EXW46_10505	COG1136	(ABC) transporter
EXW46_10510	COG0577	efflux transmembrane transporter activity
EXW46_10515	COG0577	efflux transmembrane transporter activity
EXW46_10520	COG2205	protein histidine kinase activity
EXW46_10525	COG0745	RESPONSE REGULATOR receiver
EXW46_10530	COG0640	Transcriptional regulator
EXW46_10535	COG5658	integral membrane protein
EXW46_10540	COG1131	(ABC) transporter
EXW46_10550	COG3708	Transcriptional regulator
EXW46_10550	COG2207	Transcriptional regulator
EXW46_10555	COG1136	(ABC) transporter
EXW46_10560	COG0577	efflux transmembrane transporter activity
EXW46_10600	COG1597	lipid kinase activity
EXW46_10605	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EXW46_10630	COG0745	RESPONSE REGULATOR receiver
EXW46_10635	COG5002	protein histidine kinase activity
EXW46_10640	COG3859	Proton-coupled thiamine transporter YuaJ
EXW46_10665	COG1842	Phage shock protein A
EXW46_10690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_10710	COG1294	oxidase, subunit
EXW46_10715	COG1271	oxidase subunit
EXW46_10720	COG0288	reversible hydration of carbon dioxide
EXW46_10730	COG1854	S-ribosylhomocysteine lyase activity
EXW46_10770	COG0494	nUDIX hydrolase
EXW46_10775	COG5002	protein histidine kinase activity
EXW46_10780	COG0745	RESPONSE REGULATOR receiver
EXW46_10785	COG1136	(ABC) transporter
EXW46_10790	COG0577	efflux transmembrane transporter activity
EXW46_10815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXW46_10820	COG1116	anion transmembrane transporter activity
EXW46_10825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXW46_10840	COG4895	conserved protein (DUF2196)
EXW46_10850	COG1368	sulfuric ester hydrolase activity
EXW46_10860	COG2267	carboxylic ester hydrolase activity
EXW46_10865	COG0753	catalase activity
EXW46_10870	COG3852	Histidine kinase
EXW46_10875	COG5002	protein histidine kinase activity
EXW46_10910	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EXW46_10915	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXW46_10945	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXW46_10955	COG0438	transferase activity, transferring glycosyl groups
EXW46_10960	COG0671	phosphoesterase, PA-phosphatase related
EXW46_10970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
EXW46_10975	COG2267	carboxylic ester hydrolase activity
EXW46_10990	COG1794	racemase activity, acting on amino acids and derivatives
EXW46_10995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
EXW46_11000	COG1242	4 iron, 4 sulfur cluster binding
EXW46_11020	COG1136	(ABC) transporter
EXW46_11035	COG0582	viral genome integration into host DNA
EXW46_11040	COG0490	domain, Protein
EXW46_11045	COG0475	glutathione-regulated potassium exporter activity
EXW46_11050	COG2814	Major facilitator Superfamily
EXW46_11055	COG0495	leucyl-tRNA aminoacylation
EXW46_11100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXW46_11110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_11130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW46_11135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_11140	COG0315	cyclic pyranopterin monophosphate synthase activity
EXW46_11145	COG0303	'Molybdopterin
EXW46_11150	COG1763	Mo-molybdopterin cofactor biosynthetic process
EXW46_11155	COG0314	molybdopterin synthase activity
EXW46_11180	COG1329	Transcriptional regulator
EXW46_11200	COG3832	glyoxalase III activity
EXW46_11210	COG2814	Major facilitator Superfamily
EXW46_11215	COG2081	HI0933 family
EXW46_11220	COG2244	polysaccharide biosynthetic process
EXW46_11225	COG1187	pseudouridine synthase activity
EXW46_11230	COG1349	DNA-binding transcription factor activity
EXW46_11235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW46_11245	COG1523	belongs to the glycosyl hydrolase 13 family
EXW46_11250	COG0510	thiamine kinase activity
EXW46_11260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXW46_11265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_11275	COG1363	Peptidase, m42
EXW46_11280	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
EXW46_11285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_11290	COG4848	Belongs to the UPF0354 family
EXW46_11295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW46_11310	COG1674	ftsk spoiiie
EXW46_11320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXW46_11325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_11340	COG2309	aminopeptidase activity
EXW46_11350	COG3118	belongs to the thioredoxin family
EXW46_11355	COG4851	CamS sex pheromone cAM373 precursor
EXW46_11360	COG1605	Chorismate mutase
EXW46_11360	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW46_11365	COG1605	Chorismate mutase
EXW46_11365	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW46_11370	COG1609	Transcriptional regulator
EXW46_11390	COG1970	mechanosensitive ion channel activity
EXW46_11400	COG0666	response to abiotic stimulus
EXW46_11405	COG5002	protein histidine kinase activity
EXW46_11410	COG0745	RESPONSE REGULATOR receiver
EXW46_11445	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXW46_11450	COG0517	IMP dehydrogenase activity
EXW46_11455	COG0454	-acetyltransferase
EXW46_11460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW46_11475	COG0110	maltose O-acetyltransferase activity
EXW46_11485	COG1595	DNA-templated transcription, initiation
EXW46_11510	COG0556	nucleotide-excision repair
EXW46_11540	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXW46_11545	COG0626	cystathionine gamma-synthase activity
EXW46_11550	COG1956	GAF domain-containing protein
EXW46_11555	COG1309	transcriptional regulator
EXW46_11570	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
EXW46_11575	COG1104	cysteine desulfurase activity
EXW46_11590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW46_11600	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EXW46_11615	COG3874	Sporulation protein YtfJ
EXW46_11620	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
EXW46_11625	COG0827	DNA restriction-modification system
EXW46_11630	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXW46_11650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_11665	COG0137	argininosuccinate synthase activity
EXW46_11670	COG0165	Argininosuccinate lyase
EXW46_11690	COG0589	response to stress
EXW46_11695	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_11710	COG1476	TRANSCRIPTIONal
EXW46_11720	COG0662	Cupin 2, conserved barrel domain protein
EXW46_11750	COG0006	proline dipeptidase activity
EXW46_11755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW46_11760	COG4109	DRTGG domain
EXW46_11780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXW46_11795	COG0587	DNA-directed DNA polymerase activity
EXW46_11800	COG0281	malic enzyme
EXW46_11805	COG1725	Transcriptional regulator
EXW46_11810	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXW46_11820	COG0205	6-phosphofructokinase activity
EXW46_11830	COG3030	protein affecting phage T7 exclusion by the F plasmid
EXW46_11835	COG0628	permease
EXW46_11850	COG0372	Belongs to the citrate synthase family
EXW46_11855	COG0538	isocitrate dehydrogenase activity
EXW46_11860	COG0039	L-malate dehydrogenase activity
EXW46_11875	COG0745	RESPONSE REGULATOR receiver
EXW46_11880	COG5002	protein histidine kinase activity
EXW46_11885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW46_11885	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW46_11895	COG1971	Probably functions as a manganese efflux pump
EXW46_11900	COG0237	dephospho-CoA kinase activity
EXW46_11905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXW46_11910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXW46_11915	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW46_11920	COG3611	Membrane attachment protein
EXW46_11925	COG1484	DNA-dependent DNA replication
EXW46_11935	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW46_11950	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXW46_11960	COG1363	Peptidase, m42
EXW46_11965	COG1309	transcriptional regulator
EXW46_11970	COG1566	PFAM secretion protein HlyD family protein
EXW46_11975	COG2814	Major facilitator Superfamily
EXW46_11995	COG1418	mRNA catabolic process
EXW46_12005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXW46_12010	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXW46_12045	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW46_12050	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
EXW46_12055	COG1286	toxin biosynthetic process
EXW46_12060	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW46_12060	COG1796	DNA polymerase
EXW46_12065	COG1193	negative regulation of DNA recombination
EXW46_12075	COG1114	Component of the transport system for branched-chain amino acids
EXW46_12080	COG5386	Cell surface protein
EXW46_12085	COG5386	Cell surface protein
EXW46_12100	COG1120	ATPase activity
EXW46_12105	COG4509	Sortase family
EXW46_12115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXW46_12120	COG4895	conserved protein (DUF2196)
EXW46_12125	COG0745	RESPONSE REGULATOR receiver
EXW46_12130	COG2205	protein histidine kinase activity
EXW46_12135	COG1131	(ABC) transporter
EXW46_12160	COG2318	DinB family
EXW46_12175	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_12180	COG1309	transcriptional regulator
EXW46_12185	COG1024	Enoyl-CoA hydratase
EXW46_12190	COG2086	electron transfer activity
EXW46_12195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXW46_12200	COG3118	belongs to the thioredoxin family
EXW46_12205	COG0322	excinuclease ABC activity
EXW46_12210	COG1719	4-vinyl reductase, 4VR
EXW46_12215	COG2009	succinate dehydrogenase
EXW46_12220	COG1053	succinate dehydrogenase
EXW46_12225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXW46_12230	COG0824	Thioesterase
EXW46_12235	COG1876	peptidase activity
EXW46_12245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW46_12250	COG1360	Flagellar Motor Protein
EXW46_12255	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
EXW46_12260	COG4152	abc transporter atp-binding protein
EXW46_12265	COG1668	transmembrane transport
EXW46_12270	COG1959	2 iron, 2 sulfur cluster binding
EXW46_12280	COG0697	spore germination
EXW46_12285	COG1396	sequence-specific DNA binding
EXW46_12290	COG1983	PspC domain protein
EXW46_12295	COG0402	S-adenosylhomocysteine deaminase activity
EXW46_12300	COG2233	PERMEase
EXW46_12305	COG2197	response regulator
EXW46_12315	COG5401	PFAM Sporulation and spore germination
EXW46_12320	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EXW46_12330	COG0622	Phosphoesterase
EXW46_12380	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXW46_12390	COG0470	DNA polymerase III
EXW46_12390	COG1067	ATP-dependent peptidase activity
EXW46_12400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXW46_12405	COG1764	response to oxidative stress
EXW46_12410	COG1846	Transcriptional regulator
EXW46_12415	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXW46_12420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW46_12425	COG0181	hydroxymethylbilane synthase activity
EXW46_12430	COG1587	Uroporphyrinogen-III synthase
EXW46_12435	COG0113	porphobilinogen synthase activity
EXW46_12440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXW46_12445	COG1388	LysM domain
EXW46_12460	COG0285	dihydrofolate synthase activity
EXW46_12475	COG0424	maF-like protein
EXW46_12480	COG2003	Belongs to the UPF0758 family
EXW46_12485	COG1077	Cell shape determining protein MreB Mrl
EXW46_12500	COG0850	regulation of cytokinetic process
EXW46_12505	COG2894	cell division
EXW46_12510	COG0739	heme binding
EXW46_12515	COG1994	Peptidase M50
EXW46_12520	COG1530	ribonuclease E activity
EXW46_12530	COG2868	ribosomal protein
EXW46_12540	COG3290	protein histidine kinase activity
EXW46_12545	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXW46_12550	COG0745	RESPONSE REGULATOR receiver
EXW46_12555	COG5002	protein histidine kinase activity
EXW46_12560	COG1136	(ABC) transporter
EXW46_12565	COG0577	efflux transmembrane transporter activity
EXW46_12570	COG0577	efflux transmembrane transporter activity
EXW46_12575	COG0077	Prephenate dehydratase
EXW46_12580	COG2258	MOSC domain
EXW46_12590	COG1827	regulation of RNA biosynthetic process
EXW46_12595	COG1104	cysteine desulfurase activity
EXW46_12600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXW46_12605	COG0157	Belongs to the NadC ModD family
EXW46_12610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXW46_12635	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
EXW46_12640	COG0632	four-way junction helicase activity
EXW46_12645	COG2255	four-way junction helicase activity
EXW46_12655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
EXW46_12660	COG0343	queuine tRNA-ribosyltransferase activity
EXW46_12665	COG1862	Preprotein translocase
EXW46_12675	COG2323	membrane
EXW46_12680	COG2244	polysaccharide biosynthetic process
EXW46_12690	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW46_12690	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXW46_12695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW46_12700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EXW46_12700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
EXW46_12705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW46_12710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW46_12715	COG1490	D-aminoacyl-tRNA deacylase activity
EXW46_12730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXW46_12735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW46_12745	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXW46_12750	COG1959	2 iron, 2 sulfur cluster binding
EXW46_12755	COG1104	cysteine desulfurase activity
EXW46_12760	COG0482	sulfurtransferase activity
EXW46_12770	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EXW46_12790	COG0628	permease
EXW46_12800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW46_12805	COG4472	Bacterial protein of unknown function (DUF965)
EXW46_12810	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXW46_12820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXW46_12825	COG4122	O-methyltransferase activity
EXW46_12830	COG0826	peptidase U32
EXW46_12835	COG0826	peptidase U32
EXW46_12840	COG0572	uridine kinase
EXW46_12845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXW46_12850	COG0768	penicillin binding
EXW46_12865	COG2226	methyltransferase
EXW46_12870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_12875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW46_12880	COG0626	cystathionine gamma-synthase activity
EXW46_12885	COG1454	alcohol dehydrogenase
EXW46_12885	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_12895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_12935	COG2259	Doxx family
EXW46_12940	COG2514	catechol 2,3-dioxygenase activity
EXW46_12945	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXW46_12950	COG3186	Phenylalanine-4-hydroxylase
EXW46_12955	COG1404	Belongs to the peptidase S8 family
EXW46_12990	COG2267	carboxylic ester hydrolase activity
EXW46_13000	COG1785	Belongs to the alkaline phosphatase family
EXW46_13010	COG2357	RelA SpoT domain protein
EXW46_13015	COG1595	DNA-templated transcription, initiation
EXW46_13025	COG0688	phosphatidylethanolamine metabolic process
EXW46_13035	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
EXW46_13040	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
EXW46_13045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EXW46_13050	COG1534	Rna-binding protein
EXW46_13055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXW46_13060	COG1713	HD superfamily hydrolase involved in NAD metabolism
EXW46_13065	COG0799	negative regulation of ribosome biogenesis
EXW46_13070	COG2226	methyltransferase
EXW46_13075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_13080	COG1555	photosystem II stabilization
EXW46_13080	COG1596	polysaccharide export
EXW46_13085	COG2131	deaminase
EXW46_13090	COG2333	competence protein COMEC
EXW46_13090	COG0658	competence protein
EXW46_13100	COG1466	dna polymerase III delta subunit
EXW46_13105	COG0268	Binds directly to 16S ribosomal RNA
EXW46_13110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
EXW46_13120	COG0481	GTPase activity
EXW46_13125	COG1733	regulation of RNA biosynthetic process
EXW46_13130	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXW46_13135	COG1420	regulation of RNA biosynthetic process
EXW46_13145	COG0443	Heat shock 70 kDa protein
EXW46_13150	COG0484	heat shock protein binding
EXW46_13160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXW46_13165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW46_13170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXW46_13175	COG1610	YqeY-like protein
EXW46_13190	COG1702	phosphate starvation-inducible protein PhoH
EXW46_13195	COG1480	7TM receptor with intracellular HD hydrolase
EXW46_13200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXW46_13205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXW46_13210	COG0295	cytidine deaminase activity
EXW46_13215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXW46_13225	COG1381	Involved in DNA repair and RecF pathway recombination
EXW46_13230	COG0517	IMP dehydrogenase activity
EXW46_13235	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXW46_13245	COG0358	DNA primase activity
EXW46_13250	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXW46_13255	COG2010	Cytochrome c
EXW46_13260	COG2384	SAM-dependent methyltransferase
EXW46_13265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXW46_13270	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXW46_13285	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
EXW46_13295	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_13300	COG1121	(ABC) transporter
EXW46_13305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EXW46_13310	COG0735	belongs to the Fur family
EXW46_13315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXW46_13335	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW46_13340	COG0477	Major facilitator Superfamily
EXW46_13345	COG0768	penicillin binding
EXW46_13350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXW46_13355	COG0573	inorganic phosphate transmembrane transporter activity
EXW46_13360	COG0581	inorganic phosphate transmembrane transporter activity
EXW46_13370	COG0704	Plays a role in the regulation of phosphate uptake
EXW46_13375	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXW46_13380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXW46_13385	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXW46_13390	COG4483	Protein conserved in bacteria
EXW46_13395	COG1940	carbohydrate kinase activity
EXW46_13405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_13425	COG0626	cystathionine gamma-synthase activity
EXW46_13430	COG0626	cystathionine gamma-synthase activity
EXW46_13435	COG0646	methionine synthase
EXW46_13435	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EXW46_13440	COG0646	methionine synthase
EXW46_13440	COG1410	methionine synthase
EXW46_13495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXW46_13500	COG1459	type II secretion system
EXW46_13510	COG4970	Tfp pilus assembly protein FimT
EXW46_13535	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXW46_13565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW46_13570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXW46_13575	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW46_13580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXW46_13595	COG1725	Transcriptional regulator
EXW46_13600	COG1131	(ABC) transporter
EXW46_13630	COG2076	Multidrug Resistance protein
EXW46_13635	COG2076	Multidrug Resistance protein
EXW46_13645	COG1609	Transcriptional regulator
EXW46_13655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXW46_13685	COG1321	iron dependent repressor
EXW46_13690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXW46_13700	COG3872	metal-dependent enzyme
EXW46_13710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXW46_13715	COG0006	proline dipeptidase activity
EXW46_13720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXW46_13740	COG3854	ATPases associated with a variety of cellular activities
EXW46_13785	COG0511	ligase activity, forming carbon-carbon bonds
EXW46_13790	COG0439	Biotin carboxylase
EXW46_13795	COG1302	Protein conserved in bacteria
EXW46_13800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW46_13805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW46_13810	COG1570	exodeoxyribonuclease VII activity
EXW46_13815	COG1722	exodeoxyribonuclease VII activity
EXW46_13820	COG0142	geranyltranstransferase activity
EXW46_13825	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXW46_13830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXW46_13835	COG1438	arginine binding
EXW46_13840	COG0497	DNA recombination
EXW46_13845	COG0750	zinc metalloprotease
EXW46_13855	COG0745	RESPONSE REGULATOR receiver
EXW46_13900	COG3093	addiction module antidote protein HigA
EXW46_13905	COG0584	glycerophosphoryl diester phosphodiesterase
EXW46_13915	COG3290	protein histidine kinase activity
EXW46_13915	COG3829	transcription factor binding
EXW46_13925	COG0280	phosphate acetyltransferase
EXW46_13935	COG3426	butyrate kinase activity
EXW46_13940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW46_13945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW46_13950	COG0022	dehydrogenase e1 component
EXW46_13955	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_13965	COG0772	Belongs to the SEDS family
EXW46_13970	COG2323	membrane
EXW46_13975	COG2816	NAD+ diphosphatase activity
EXW46_13985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_13990	COG0765	amino acid transport
EXW46_13995	COG1126	abc transporter atp-binding protein
EXW46_14010	COG4129	membrane
EXW46_14015	COG1376	ErfK ybiS ycfS ynhG family protein
EXW46_14025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_14030	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW46_14055	COG1234	tRNA 3'-trailer cleavage
EXW46_14065	COG1760	l-serine dehydratase
EXW46_14070	COG1760	l-serine dehydratase
EXW46_14075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_14080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_14085	COG0300	oxidoreductase activity
EXW46_14095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXW46_14130	COG1522	sequence-specific DNA binding
EXW46_14140	COG0737	Belongs to the 5'-nucleotidase family
EXW46_14145	COG1757	Na H antiporter
EXW46_14155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_14165	COG0156	8-amino-7-oxononanoate synthase activity
EXW46_14170	COG1073	alpha beta
EXW46_14170	COG2226	methyltransferase
EXW46_14175	COG4106	trans-aconitate 2-methyltransferase activity
EXW46_14180	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EXW46_14195	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW46_14195	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EXW46_14200	COG0307	riboflavin synthase, alpha
EXW46_14205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW46_14205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXW46_14220	COG1073	alpha beta
EXW46_14225	COG0456	acetyltransferase
EXW46_14230	COG1609	Transcriptional regulator
EXW46_14235	COG2056	Na+-H+ antiporter family
EXW46_14240	COG0596	Alpha beta hydrolase
EXW46_14255	COG1525	nuclease
EXW46_14255	COG4085	toxin activity
EXW46_14255	COG0737	Belongs to the 5'-nucleotidase family
EXW46_14265	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_14265	COG0456	acetyltransferase
EXW46_14270	COG0656	L-ascorbic acid biosynthetic process
EXW46_14275	COG0667	Aldo Keto reductase
EXW46_14295	COG1300	Membrane
EXW46_14300	COG0735	belongs to the Fur family
EXW46_14310	COG4974	Belongs to the 'phage' integrase family
EXW46_14320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EXW46_14335	COG0598	Magnesium transport protein CorA
EXW46_14350	COG1846	Transcriptional regulator
EXW46_14370	COG1131	(ABC) transporter
EXW46_14375	COG1725	Transcriptional regulator
EXW46_14380	COG1686	Belongs to the peptidase S11 family
EXW46_14400	COG0733	neurotransmitter:sodium symporter activity
EXW46_14425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_14440	COG0697	spore germination
EXW46_14445	COG0561	phosphatase activity
EXW46_14450	COG4086	secreted protein
EXW46_14455	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EXW46_14465	COG1547	Domain of unknown function (DUF309)
EXW46_14475	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EXW46_14485	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXW46_14495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXW46_14500	COG0363	glucosamine-6-phosphate deaminase activity
EXW46_14505	COG2188	Transcriptional regulator
EXW46_14515	COG3711	transcriptional antiterminator
EXW46_14520	COG1263	PTS System
EXW46_14520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EXW46_14520	COG2190	(PTS) system
EXW46_14545	COG0778	Nitroreductase
EXW46_14550	COG2199	diguanylate cyclase activity
EXW46_14560	COG2084	Dehydrogenase
EXW46_14575	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
EXW46_14580	COG0235	Class ii aldolase
EXW46_14590	COG1850	ribulose-bisphosphate carboxylase activity
EXW46_14595	COG0436	Aminotransferase
EXW46_14600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXW46_14605	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
EXW46_14610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EXW46_14620	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_14625	COG1695	Transcriptional regulator
EXW46_14660	COG0183	Belongs to the thiolase family
EXW46_14665	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXW46_14705	COG3842	ATPase activity
EXW46_14710	COG0366	Alpha amylase catalytic
EXW46_14720	COG2182	Extracellular solute-binding protein
EXW46_14725	COG1175	transmembrane transport
EXW46_14730	COG3833	ABC-type maltose transport systems, permease component
EXW46_14735	COG1609	Transcriptional regulator
EXW46_14740	COG0436	Aminotransferase
EXW46_14750	COG2205	protein histidine kinase activity
EXW46_14760	COG3209	COG3209 Rhs family protein
EXW46_14770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EXW46_14780	COG2814	Major facilitator Superfamily
EXW46_14825	COG1408	metallophosphoesterase
EXW46_14830	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_14835	COG2200	EAL domain
EXW46_14850	COG4703	Protein of unknown function (DUF1797)
EXW46_14860	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
EXW46_14870	COG0517	IMP dehydrogenase activity
EXW46_14875	COG0583	DNA-binding transcription factor activity
EXW46_14880	COG2171	N-acyltransferase activity
EXW46_14885	COG1473	amidohydrolase
EXW46_14895	COG0569	domain protein
EXW46_14900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW46_14905	COG5503	Protein of unknown function (DUF1447)
EXW46_14915	COG0561	phosphatase activity
EXW46_14930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW46_14935	COG0022	dehydrogenase e1 component
EXW46_14940	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_14985	COG1982	Orn Lys Arg decarboxylase major
EXW46_14990	COG4476	Belongs to the UPF0223 family
EXW46_14995	COG4493	Belongs to the UPF0637 family
EXW46_15005	COG0483	inositol monophosphate 1-phosphatase activity
EXW46_15015	COG1217	gtp-binding protein TYPA
EXW46_15030	COG4896	Protein conserved in bacteria
EXW46_15040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXW46_15045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXW46_15050	COG4838	Belongs to the UPF0358 family
EXW46_15055	COG0772	Belongs to the SEDS family
EXW46_15065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EXW46_15070	COG1612	heme a metabolic process
EXW46_15075	COG0109	protoheme IX farnesyltransferase activity
EXW46_15100	COG3336	cytochrome c oxidase
EXW46_15110	COG2340	Cysteine-rich secretory protein family
EXW46_15125	COG0406	alpha-ribazole phosphatase activity
EXW46_15130	COG3679	Belongs to the UPF0342 family
EXW46_15135	COG4471	UPF0298 protein
EXW46_15145	COG0742	ribosomal rna small subunit methyltransferase
EXW46_15155	COG3314	Sporulation integral membrane protein YlbJ
EXW46_15160	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW46_15165	COG3480	Lon protease (S16) C-terminal proteolytic domain
EXW46_15170	COG1323	Belongs to the UPF0348 family
EXW46_15175	COG1399	metal-binding, possibly nucleic acid-binding protein
EXW46_15180	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXW46_15190	COG0454	-acetyltransferase
EXW46_15195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW46_15200	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
EXW46_15205	COG0275	rRNA processing
EXW46_15215	COG0768	penicillin binding
EXW46_15220	COG0768	penicillin binding
EXW46_15225	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXW46_15230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXW46_15235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXW46_15240	COG0772	Belongs to the SEDS family
EXW46_15255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXW46_15260	COG0849	cell division
EXW46_15265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXW46_15275	COG1191	sigma factor activity
EXW46_15280	COG1191	sigma factor activity
EXW46_15285	COG1873	PFAM PRC-barrel domain
EXW46_15295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EXW46_15300	COG1799	cell septum assembly
EXW46_15305	COG0762	integral membrane protein
EXW46_15310	COG2302	S4 RNA-binding domain
EXW46_15315	COG3599	regulation of cell shape
EXW46_15320	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXW46_15330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXW46_15335	COG0564	pseudouridine synthase activity
EXW46_15340	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXW46_15350	COG0540	Belongs to the ATCase OTCase family
EXW46_15355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EXW46_15365	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXW46_15370	COG0543	2 iron, 2 sulfur cluster binding
EXW46_15375	COG0167	dihydroorotate dehydrogenase activity
EXW46_15385	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXW46_15395	COG3069	C4-dicarboxylate transmembrane transporter activity
EXW46_15410	COG0006	proline dipeptidase activity
EXW46_15425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXW46_15430	COG1561	YicC-like family, N-terminal region
EXW46_15445	COG1758	RNA polymerase activity
EXW46_15450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW46_15455	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXW46_15460	COG0242	peptide deformylase activity
EXW46_15465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXW46_15470	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXW46_15470	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXW46_15475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXW46_15480	COG0631	protein serine/threonine phosphatase activity
EXW46_15485	COG2815	serine threonine protein kinase
EXW46_15485	COG0515	serine threonine protein kinase
EXW46_15495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXW46_15500	COG1564	THIamine pyrophosphokinase
EXW46_15515	COG1302	Protein conserved in bacteria
EXW46_15520	COG1461	Dihydroxyacetone kinase
EXW46_15530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXW46_15535	COG2050	protein possibly involved in aromatic compounds catabolism
EXW46_15535	COG1349	DNA-binding transcription factor activity
EXW46_15540	COG0416	fatty acid biosynthetic process
EXW46_15545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EXW46_15550	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_15555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW46_15560	COG0571	ribonuclease III activity
EXW46_15565	COG1196	nuclear chromosome segregation
EXW46_15570	COG0552	protein localization to endoplasmic reticulum
EXW46_15580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXW46_15590	COG1837	Belongs to the UPF0109 family
EXW46_15595	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXW46_15600	COG0336	Belongs to the RNA methyltransferase TrmD family
EXW46_15605	COG0335	large ribosomal subunit rRNA binding
EXW46_15620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXW46_15625	COG0045	succinate-CoA ligase (ADP-forming) activity
EXW46_15630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXW46_15635	COG0758	DNA mediated transformation
EXW46_15640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW46_15645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
EXW46_15650	COG4974	Belongs to the 'phage' integrase family
EXW46_15655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXW46_15660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXW46_15665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW46_15670	COG0052	Belongs to the universal ribosomal protein uS2 family
EXW46_15675	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXW46_15680	COG0528	UMP kinase activity
EXW46_15685	COG0233	cytoplasmic translational termination
EXW46_15695	COG4589	Belongs to the CDS family
EXW46_15705	COG0750	zinc metalloprotease
EXW46_15710	COG0442	prolyl-tRNA aminoacylation
EXW46_15720	COG0779	Required for maturation of 30S ribosomal subunits
EXW46_15725	COG0195	Participates in both transcription termination and antitermination
EXW46_15730	COG2740	Nucleic-acid-binding protein implicated in transcription termination
EXW46_15735	COG1358	cellular component organization or biogenesis
EXW46_15740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXW46_15745	COG1550	Protein conserved in bacteria
EXW46_15750	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXW46_15760	COG0196	riboflavin kinase activity
EXW46_15770	COG1185	polyribonucleotide nucleotidyltransferase activity
EXW46_15775	COG0726	polysaccharide deacetylase
EXW46_15780	COG0612	Peptidase, M16
EXW46_15785	COG1873	PFAM PRC-barrel domain
EXW46_15790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXW46_15795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXW46_15800	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW46_15805	COG0527	aspartate kinase activity
EXW46_15815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EXW46_15820	COG0740	serine-type endopeptidase activity
EXW46_15830	COG1674	ftsk spoiiie
EXW46_15840	COG2188	Transcriptional regulator
EXW46_15845	COG1744	ABC transporter substrate-binding protein PnrA-like
EXW46_15850	COG3845	ABC transporter
EXW46_15855	COG4603	Belongs to the binding-protein-dependent transport system permease family
EXW46_15860	COG1079	Belongs to the binding-protein-dependent transport system permease family
EXW46_15865	COG0612	Peptidase, M16
EXW46_15870	COG0612	Peptidase, M16
EXW46_15875	COG0300	oxidoreductase activity
EXW46_15890	COG1426	Protein conserved in bacteria
EXW46_15895	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXW46_15900	COG1058	Belongs to the CinA family
EXW46_15900	COG1546	Belongs to the CinA family
EXW46_15915	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXW46_15920	COG1418	mRNA catabolic process
EXW46_15925	COG1692	metallophosphoesterase
EXW46_15930	COG2359	stage V sporulation protein S
EXW46_15940	COG0674	pyruvate-flavodoxin oxidoreductase activity
EXW46_15940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
EXW46_15945	COG1013	pyruvate-flavodoxin oxidoreductase activity
EXW46_15950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXW46_15955	COG4550	Control of competence regulator ComK, YlbF/YmcA
EXW46_15965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXW46_15970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXW46_15975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
EXW46_15985	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW46_15990	COG1368	sulfuric ester hydrolase activity
EXW46_16000	COG3773	Cell wall hydrolase
EXW46_16010	COG2723	6-phospho-beta-galactosidase activity
EXW46_16015	COG2188	Transcriptional regulator
EXW46_16025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW46_16035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_16045	COG1346	cytolysis
EXW46_16065	COG1086	Polysaccharide biosynthesis protein
EXW46_16085	COG5001	Diguanylate cyclase
EXW46_16085	COG3300	MHYT domain
EXW46_16090	COG0346	lactoylglutathione lyase activity
EXW46_16095	COG2267	carboxylic ester hydrolase activity
EXW46_16105	COG2364	Membrane
EXW46_16110	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW46_16115	COG2706	6-phosphogluconolactonase activity
EXW46_16125	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
EXW46_16130	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW46_16135	COG2169	Transcriptional regulator
EXW46_16140	COG0708	Exodeoxyribonuclease III
EXW46_16145	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_16150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_16155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXW46_16160	COG1120	ATPase activity
EXW46_16165	COG2819	hydrolase of the alpha beta superfamily
EXW46_16185	COG1937	Protein conserved in bacteria
EXW46_16190	COG2608	mercury ion transmembrane transporter activity
EXW46_16195	COG2217	Heavy metal translocating P-type atpase
EXW46_16210	COG2116	formate transmembrane transporter activity
EXW46_16215	COG1408	metallophosphoesterase
EXW46_16225	COG2322	membrane
EXW46_16230	COG1979	alcohol dehydrogenase
EXW46_16235	COG1349	DNA-binding transcription factor activity
EXW46_16240	COG1105	Belongs to the carbohydrate kinase PfkB family
EXW46_16245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW46_16245	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EXW46_16245	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_16250	COG3584	3D domain protein
EXW46_16250	COG1388	LysM domain
EXW46_16260	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXW46_16280	COG0464	growth
EXW46_16285	COG2860	membrane
EXW46_16290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW46_16295	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
EXW46_16300	COG0789	Transcriptional regulator
EXW46_16305	COG0174	glutamine synthetase
EXW46_16310	COG3944	biosynthesis protein
EXW46_16315	COG0489	protein tyrosine kinase activity
EXW46_16320	COG1086	Polysaccharide biosynthesis protein
EXW46_16325	COG0438	transferase activity, transferring glycosyl groups
EXW46_16330	COG0438	transferase activity, transferring glycosyl groups
EXW46_16335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
EXW46_16335	COG0463	Glycosyl transferase, family 2
EXW46_16355	COG1216	Glycosyl transferase, family 2
EXW46_16385	COG0438	transferase activity, transferring glycosyl groups
EXW46_16390	COG1216	Glycosyl transferase, family 2
EXW46_16390	COG1442	glycosyl transferase family 8
EXW46_16395	COG5434	Belongs to the glycosyl hydrolase 28 family
EXW46_16405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXW46_16410	COG0110	maltose O-acetyltransferase activity
EXW46_16415	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXW46_16450	COG1132	(ABC) transporter
EXW46_16455	COG1695	Transcriptional regulator
EXW46_16470	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXW46_16475	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EXW46_16485	COG0737	Belongs to the 5'-nucleotidase family
EXW46_16490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_16500	COG3639	organic phosphonate transmembrane transporter activity
EXW46_16520	COG3763	UPF0154 protein
EXW46_16525	COG1132	(ABC) transporter
EXW46_16530	COG1132	(ABC) transporter
EXW46_16550	COG3409	Peptidoglycan-binding domain 1 protein
EXW46_16550	COG5632	N-Acetylmuramoyl-L-alanine amidase
EXW46_16560	COG0730	response to heat
EXW46_16575	COG1346	cytolysis
EXW46_16585	COG0583	DNA-binding transcription factor activity
EXW46_16595	COG1131	(ABC) transporter
EXW46_16600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_16605	COG1473	amidohydrolase
EXW46_16620	COG0785	Cytochrome C biogenesis protein
EXW46_16625	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW46_16655	COG2226	methyltransferase
EXW46_16665	COG2986	histidine ammonia-lyase
EXW46_16670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXW46_16675	COG1228	amidohydrolase
EXW46_16680	COG0010	Belongs to the arginase family
EXW46_16685	COG1329	Transcriptional regulator
EXW46_16695	COG1902	pentaerythritol trinitrate reductase activity
EXW46_16700	COG0069	glutamate synthase activity
EXW46_16705	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_16710	COG0346	lactoylglutathione lyase activity
EXW46_16715	COG0400	carboxylic ester hydrolase activity
EXW46_16725	COG5002	protein histidine kinase activity
EXW46_16740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_16775	COG1396	sequence-specific DNA binding
EXW46_16780	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_16785	COG1268	BioY protein
EXW46_16790	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_16795	COG0183	Belongs to the thiolase family
EXW46_16810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXW46_16820	COG2211	Major facilitator Superfamily
EXW46_16850	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXW46_16855	COG1266	CAAX protease self-immunity
EXW46_16860	COG1132	(ABC) transporter
EXW46_16880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_16910	COG0824	Thioesterase
EXW46_16915	COG4841	protein insertion into membrane
EXW46_16925	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXW46_16925	COG1328	CTP reductase activity
EXW46_16935	COG0745	RESPONSE REGULATOR receiver
EXW46_16940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXW46_16945	COG1832	CoA-binding protein
EXW46_16950	COG0187	DNA topoisomerase II activity
EXW46_16955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EXW46_16960	COG0673	inositol 2-dehydrogenase activity
EXW46_16980	COG1131	(ABC) transporter
EXW46_16990	COG4166	transmembrane transport
EXW46_16995	COG4166	transmembrane transport
EXW46_17000	COG4166	transmembrane transport
EXW46_17005	COG2226	methyltransferase
EXW46_17040	COG3326	Membrane
EXW46_17045	COG2962	Rard protein
EXW46_17050	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
EXW46_17055	COG1657	PFAM Prenyltransferase squalene oxidase
EXW46_17065	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_17070	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_17080	COG4145	pantothenate transmembrane transporter activity
EXW46_17095	COG0165	Argininosuccinate lyase
EXW46_17105	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_17125	COG0494	nUDIX hydrolase
EXW46_17135	COG0716	FMN binding
EXW46_17145	COG1278	Cold shock
EXW46_17170	COG2720	vancomycin resistance protein
EXW46_17175	COG0765	amino acid transport
EXW46_17180	COG1126	abc transporter atp-binding protein
EXW46_17185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXW46_17190	COG2514	catechol 2,3-dioxygenase activity
EXW46_17205	COG1285	pathogenesis
EXW46_17225	COG0277	FAD linked oxidase domain protein
EXW46_17235	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_17240	COG2808	Putative FMN-binding domain
EXW46_17250	COG0457	Tetratricopeptide repeat
EXW46_17265	COG0604	alcohol dehydrogenase
EXW46_17270	COG0640	Transcriptional regulator
EXW46_17300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_17315	COG3781	membrane
EXW46_17340	COG1164	Oligoendopeptidase f
EXW46_17345	COG2162	N-hydroxyarylamine O-acetyltransferase activity
EXW46_17365	COG1193	negative regulation of DNA recombination
EXW46_17385	COG0583	DNA-binding transcription factor activity
EXW46_17415	COG3739	integral membrane protein
EXW46_17435	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EXW46_17440	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW46_17455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_17460	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_17465	COG0534	Mate efflux family protein
EXW46_17475	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_17480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_17495	COG2814	Major facilitator Superfamily
EXW46_17500	COG5002	protein histidine kinase activity
EXW46_17505	COG0745	RESPONSE REGULATOR receiver
EXW46_17510	COG5002	protein histidine kinase activity
EXW46_17530	COG1113	amino acid transport
EXW46_17535	COG0604	alcohol dehydrogenase
EXW46_17540	COG1695	Transcriptional regulator
EXW46_17590	COG2072	flavoprotein involved in K transport
EXW46_17630	COG1151	hydroxylamine reductase activity
EXW46_17660	COG0814	amino acid
EXW46_17710	COG0745	RESPONSE REGULATOR receiver
EXW46_17715	COG5002	protein histidine kinase activity
EXW46_17740	COG0741	lytic transglycosylase activity
EXW46_17780	COG1876	peptidase activity
EXW46_17795	COG1191	sigma factor activity
EXW46_17810	COG1733	regulation of RNA biosynthetic process
EXW46_17815	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXW46_17820	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_17830	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_17840	COG0384	phenazine biosynthesis protein PhzF
EXW46_17855	COG0494	nUDIX hydrolase
EXW46_17870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_17880	COG4702	Belongs to the UPF0303 family
EXW46_17885	COG3813	Protein conserved in bacteria
EXW46_17890	COG1357	PFAM Pentapeptide repeats (8 copies)
EXW46_17895	COG0697	spore germination
EXW46_17900	COG0789	Transcriptional regulator
EXW46_17905	COG1253	flavin adenine dinucleotide binding
EXW46_17915	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
EXW46_17935	COG0477	Major facilitator Superfamily
EXW46_17965	COG2261	transglycosylase associated protein
EXW46_17970	COG0628	permease
EXW46_18005	COG2365	Tyrosine phosphatase family
EXW46_18010	COG1011	Hydrolase
EXW46_18025	COG1595	DNA-templated transcription, initiation
EXW46_18055	COG1131	(ABC) transporter
EXW46_18065	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_18085	COG1733	regulation of RNA biosynthetic process
EXW46_18090	COG0778	Nitroreductase
EXW46_18095	COG1785	Belongs to the alkaline phosphatase family
EXW46_18115	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXW46_18125	COG0384	phenazine biosynthesis protein PhzF
EXW46_18130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_18160	COG3620	sequence-specific DNA binding
EXW46_18165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_18170	COG2356	endonuclease I
EXW46_18175	COG1288	antiporter activity
EXW46_18180	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXW46_18235	COG2031	fatty acid transporter
EXW46_18255	COG0833	amino acid
EXW46_18265	COG1414	Transcriptional regulator
EXW46_18270	COG4187	Peptidase family M20/M25/M40
EXW46_18365	COG1131	(ABC) transporter
EXW46_18380	COG1136	(ABC) transporter
EXW46_18395	COG5002	protein histidine kinase activity
EXW46_18440	COG2814	Major facilitator Superfamily
EXW46_18445	COG1309	transcriptional regulator
EXW46_18460	COG4257	antibiotic catabolic process
EXW46_18480	COG0640	Transcriptional regulator
EXW46_18500	COG2814	Major facilitator Superfamily
EXW46_18505	COG1846	Transcriptional regulator
EXW46_18520	COG0477	Major facilitator Superfamily
EXW46_18560	COG5444	nuclease activity
EXW46_18565	COG2849	repeat protein
EXW46_18645	COG2814	Major facilitator Superfamily
EXW46_18690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXW46_18710	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXW46_18735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_18745	COG3850	Histidine kinase
EXW46_18745	COG5002	protein histidine kinase activity
EXW46_18760	COG0577	efflux transmembrane transporter activity
EXW46_18765	COG1136	(ABC) transporter
EXW46_18785	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EXW46_18825	COG2318	DinB family
EXW46_18845	COG0662	Cupin 2, conserved barrel domain protein
EXW46_18905	COG4977	sequence-specific DNA binding
EXW46_18965	COG2515	1-aminocyclopropane-1-carboxylate deaminase
EXW46_18985	COG2814	Major facilitator Superfamily
EXW46_19000	COG0745	RESPONSE REGULATOR receiver
EXW46_19005	COG2205	protein histidine kinase activity
EXW46_19010	COG1136	(ABC) transporter
EXW46_19015	COG0577	efflux transmembrane transporter activity
EXW46_19040	COG1136	(ABC) transporter
EXW46_19055	COG0277	FAD linked oxidase domain protein
EXW46_19100	COG5002	protein histidine kinase activity
EXW46_19100	COG3850	Histidine kinase
EXW46_19105	COG0745	RESPONSE REGULATOR receiver
EXW46_19130	COG0346	lactoylglutathione lyase activity
EXW46_19145	COG1522	sequence-specific DNA binding
EXW46_19150	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_19155	COG1309	transcriptional regulator
EXW46_19160	COG1090	epimerase
EXW46_19170	COG0640	Transcriptional regulator
EXW46_19175	COG0346	lactoylglutathione lyase activity
EXW46_19180	COG0798	PFAM Bile acid sodium symporter
EXW46_19200	COG1575	Belongs to the MenA family. Type 1 subfamily
EXW46_19210	COG0745	RESPONSE REGULATOR receiver
EXW46_19215	COG5002	protein histidine kinase activity
EXW46_19295	COG1309	transcriptional regulator
EXW46_19300	COG2814	Major facilitator Superfamily
EXW46_19310	COG0583	DNA-binding transcription factor activity
EXW46_19335	COG1335	isochorismatase
EXW46_19340	COG2267	carboxylic ester hydrolase activity
EXW46_19345	COG0737	Belongs to the 5'-nucleotidase family
EXW46_19360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXW46_19370	COG0574	Belongs to the PEP-utilizing enzyme family
EXW46_19370	COG3848	Pyruvate phosphate dikinase
EXW46_19385	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
EXW46_19405	COG3314	Sporulation integral membrane protein YlbJ
EXW46_19415	COG0640	Transcriptional regulator
EXW46_19440	COG1960	acyl-CoA dehydrogenase activity
EXW46_19450	COG0640	Transcriptional regulator
EXW46_19470	COG1414	Transcriptional regulator
EXW46_19475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EXW46_19480	COG1984	allophanate hydrolase subunit 2
EXW46_19485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EXW46_19500	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
EXW46_19510	COG0768	penicillin binding
EXW46_19545	COG4335	DNA alkylation repair
EXW46_19555	COG0833	amino acid
EXW46_19565	COG0730	response to heat
EXW46_19590	COG0456	acetyltransferase
EXW46_19590	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_19610	COG1671	Belongs to the UPF0178 family
EXW46_19620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_19625	COG0697	spore germination
EXW46_19640	COG0456	acetyltransferase
EXW46_19645	COG2207	Transcriptional regulator
EXW46_19675	COG1309	transcriptional regulator
EXW46_19680	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_19690	COG3831	ATPase activity
EXW46_19690	COG4884	unkown
EXW46_19705	COG2814	Major facilitator Superfamily
EXW46_19710	COG2508	Transcriptional regulator
EXW46_19720	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_19735	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
EXW46_19740	COG1447	Phosphotransferase system cellobiose-specific component IIA
EXW46_19745	COG2723	6-phospho-beta-galactosidase activity
EXW46_19750	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXW46_19755	COG1024	Enoyl-CoA hydratase
EXW46_19760	COG0183	Belongs to the thiolase family
EXW46_19765	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_19775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXW46_19785	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXW46_19810	COG1846	Transcriptional regulator
EXW46_19815	COG0778	Nitroreductase
EXW46_19825	COG0714	Associated with various cellular activities
EXW46_19850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
EXW46_19860	COG0753	catalase activity
EXW46_19865	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXW46_19885	COG0714	Associated with various cellular activities
EXW46_19910	COG0346	lactoylglutathione lyase activity
EXW46_19915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_19955	COG3655	Transcriptional regulator
EXW46_19965	COG1349	DNA-binding transcription factor activity
EXW46_19970	COG1175	transmembrane transport
EXW46_19995	COG3842	ATPase activity
EXW46_20015	COG3239	Fatty acid desaturase
EXW46_20020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EXW46_20025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXW46_20030	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXW46_20035	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_20060	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_20075	COG2226	methyltransferase
EXW46_20095	COG2390	Transcriptional regulator
EXW46_20100	COG1129	ABC transporter
EXW46_20115	COG1879	ABC-type sugar transport system periplasmic component
EXW46_20120	COG0579	oxidoreductase
EXW46_20150	COG0431	NADPH-dependent FMN reductase
EXW46_20155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXW46_20160	COG0346	lactoylglutathione lyase activity
EXW46_20170	COG1388	LysM domain
EXW46_20170	COG3584	3D domain protein
EXW46_20210	COG0189	ligase activity
EXW46_20230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
EXW46_20230	COG1605	Chorismate mutase
EXW46_20245	COG0287	Prephenate dehydrogenase
EXW46_20265	COG0494	nUDIX hydrolase
EXW46_20270	COG1309	transcriptional regulator
EXW46_20280	COG1033	growth of symbiont in host cell
EXW46_20280	COG2409	Drug exporters of the RND superfamily
EXW46_20285	COG0488	(ABC) transporter
EXW46_20300	COG1368	sulfuric ester hydrolase activity
EXW46_20320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXW46_20350	COG4912	Dna alkylation repair
EXW46_20370	COG2318	DinB family
EXW46_20375	COG0697	spore germination
EXW46_20395	COG2746	aminoglycoside 3-N-acetyltransferase activity
EXW46_20425	COG0628	permease
EXW46_20465	COG2188	Transcriptional regulator
EXW46_20470	COG1131	(ABC) transporter
EXW46_20485	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
EXW46_20495	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXW46_20500	COG0436	Aminotransferase
EXW46_20535	COG2226	methyltransferase
EXW46_20550	COG2261	transglycosylase associated protein
EXW46_20570	COG2814	Major facilitator Superfamily
EXW46_20570	COG0477	Major facilitator Superfamily
EXW46_20575	COG4533	DNA binding
EXW46_20580	COG0789	Transcriptional regulator
EXW46_20585	COG1664	Polymer-forming cytoskeletal
EXW46_20595	COG2814	Major facilitator Superfamily
EXW46_20650	COG1307	EDD domain protein, DegV family
EXW46_20655	COG1164	Oligoendopeptidase f
EXW46_20665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_20690	COG0745	RESPONSE REGULATOR receiver
EXW46_20700	COG2936	dipeptidyl-peptidase activity
EXW46_20750	COG0667	Aldo Keto reductase
EXW46_20770	COG4948	Mandelate Racemase Muconate Lactonizing
EXW46_20780	COG4166	transmembrane transport
EXW46_20785	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
EXW46_20800	COG0586	Pfam SNARE associated Golgi protein
EXW46_20845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_20850	COG3938	Belongs to the proline racemase family
EXW46_20860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXW46_20865	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_20870	COG1115	amino acid carrier protein
EXW46_20875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW46_20880	COG1162	GTPase activity
EXW46_20895	COG2318	DinB family
EXW46_20900	COG3397	chitin binding
EXW46_20905	COG1227	inorganic diphosphatase activity
EXW46_20915	COG4637	Psort location Cytoplasmic, score
EXW46_20935	COG0514	ATP-dependent DNA helicase (RecQ)
EXW46_20940	COG2105	PFAM AIG2 family protein
EXW46_20950	COG3973	AAA domain
EXW46_20995	COG2315	Protein conserved in bacteria
EXW46_21000	COG2205	protein histidine kinase activity
EXW46_21020	COG1819	glycosyl
EXW46_21030	COG3397	chitin binding
EXW46_21035	COG2153	protein acetylation
EXW46_21040	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXW46_21065	COG4175	Glycine betaine
EXW46_21065	COG0517	IMP dehydrogenase activity
EXW46_21070	COG4176	ABC-type proline glycine betaine transport system permease component
EXW46_21105	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_21105	COG0456	acetyltransferase
EXW46_21110	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_21120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EXW46_21125	COG0022	dehydrogenase e1 component
EXW46_21130	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXW46_21135	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXW46_21150	COG4824	toxin secretion phage lysis holin
EXW46_21180	COG1349	DNA-binding transcription factor activity
EXW46_21195	COG3284	Transcriptional regulator
EXW46_21210	COG1309	transcriptional regulator
EXW46_21215	COG3844	kynureninase activity
EXW46_21220	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXW46_21225	COG3483	tryptophan 2,3-dioxygenase activity
EXW46_21255	COG2959	enzyme of heme biosynthesis
EXW46_21270	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_21305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW46_21310	COG3386	PFAM SMP-30 Gluconolaconase
EXW46_21320	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EXW46_21325	COG3773	Cell wall hydrolase
EXW46_21340	COG0745	RESPONSE REGULATOR receiver
EXW46_21345	COG2205	protein histidine kinase activity
EXW46_21350	COG0583	DNA-binding transcription factor activity
EXW46_21355	COG0667	Aldo Keto reductase
EXW46_21360	COG0488	(ABC) transporter
EXW46_21375	COG1136	(ABC) transporter
EXW46_21380	COG0577	efflux transmembrane transporter activity
EXW46_21400	COG0460	homoserine dehydrogenase
EXW46_21405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_21415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EXW46_21455	COG2124	cytochrome p450
EXW46_21505	COG0561	phosphatase activity
EXW46_21510	COG5002	protein histidine kinase activity
EXW46_21515	COG0768	penicillin binding
EXW46_21525	COG1819	glycosyl
EXW46_21530	COG1794	racemase activity, acting on amino acids and derivatives
EXW46_21535	COG4720	Psort location CytoplasmicMembrane, score
EXW46_21540	COG1122	ATPase activity
EXW46_21555	COG2205	protein histidine kinase activity
EXW46_21565	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EXW46_21575	COG0745	RESPONSE REGULATOR receiver
EXW46_21580	COG5002	protein histidine kinase activity
EXW46_21585	COG0604	alcohol dehydrogenase
EXW46_21590	COG0671	phosphoesterase, PA-phosphatase related
EXW46_21595	COG0768	penicillin binding
EXW46_21640	COG2814	Major facilitator Superfamily
EXW46_21660	COG0584	glycerophosphoryl diester phosphodiesterase
EXW46_21675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_21680	COG0697	spore germination
EXW46_21700	COG0494	nUDIX hydrolase
EXW46_21710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_21715	COG2223	nitrite transmembrane transporter activity
EXW46_21720	COG2816	NAD+ diphosphatase activity
EXW46_21725	COG0592	DNA-directed DNA polymerase activity
EXW46_21730	COG1051	belongs to the nudix hydrolase family
EXW46_21770	COG3878	Protein conserved in bacteria
EXW46_21795	COG4667	esterase of the alpha-beta hydrolase superfamily
EXW46_21810	COG2318	DinB family
EXW46_21835	COG0322	excinuclease ABC activity
EXW46_21855	COG3961	Belongs to the TPP enzyme family
EXW46_21860	COG1132	(ABC) transporter
EXW46_21875	COG1183	phosphatidylcholine synthase activity
EXW46_21880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXW46_21905	COG1011	Hydrolase
EXW46_21910	COG0745	RESPONSE REGULATOR receiver
EXW46_21915	COG5002	protein histidine kinase activity
EXW46_21925	COG1136	(ABC) transporter
EXW46_21930	COG0577	efflux transmembrane transporter activity
EXW46_21940	COG1073	alpha beta
EXW46_21950	COG0657	acetylesterase activity
EXW46_21955	COG0076	glutamate decarboxylase activity
EXW46_21970	COG1523	belongs to the glycosyl hydrolase 13 family
EXW46_21975	COG3227	Zinc metalloprotease (Elastase)
EXW46_21980	COG0737	Belongs to the 5'-nucleotidase family
EXW46_21990	COG0201	protein transport
EXW46_21995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXW46_22000	COG0697	spore germination
EXW46_22005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_22020	COG2323	membrane
EXW46_22030	COG1063	alcohol dehydrogenase
EXW46_22050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_22055	COG0697	spore germination
EXW46_22085	COG1309	transcriptional regulator
EXW46_22125	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_22140	COG0693	protein deglycase activity
EXW46_22160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EXW46_22185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXW46_22210	COG1686	Belongs to the peptidase S11 family
EXW46_22215	COG2318	DinB family
EXW46_22220	COG0572	uridine kinase
EXW46_22260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXW46_22265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXW46_22270	COG1024	Enoyl-CoA hydratase
EXW46_22275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW46_22280	COG0511	ligase activity, forming carbon-carbon bonds
EXW46_22285	COG0439	Biotin carboxylase
EXW46_22290	COG1960	acyl-CoA dehydrogenase activity
EXW46_22310	COG1309	transcriptional regulator
EXW46_22320	COG1131	(ABC) transporter
EXW46_22330	COG1408	metallophosphoesterase
EXW46_22340	COG0768	penicillin binding
EXW46_22345	COG0768	penicillin binding
EXW46_22355	COG1595	DNA-templated transcription, initiation
EXW46_22360	COG0768	penicillin binding
EXW46_22385	COG1686	Belongs to the peptidase S11 family
EXW46_22395	COG2195	Cleaves the N-terminal amino acid of tripeptides
EXW46_22415	COG0588	phosphoglycerate mutase activity
EXW46_22425	COG0693	protein deglycase activity
EXW46_22435	COG0500	methyltransferase
EXW46_22435	COG3615	Tellurite resistance protein tehB
EXW46_22440	COG0577	efflux transmembrane transporter activity
EXW46_22440	COG1136	(ABC) transporter
EXW46_22455	COG1309	transcriptional regulator
EXW46_22510	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXW46_22520	COG2971	BadF BadG BcrA BcrD
EXW46_22525	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXW46_22550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
EXW46_22550	COG2755	lipolytic protein G-D-S-L family
EXW46_22630	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_22645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_22670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_22685	COG2226	methyltransferase
EXW46_22720	COG1595	DNA-templated transcription, initiation
EXW46_22725	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EXW46_22735	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXW46_22765	COG1396	sequence-specific DNA binding
EXW46_22850	COG0582	viral genome integration into host DNA
EXW46_22855	COG1132	(ABC) transporter
EXW46_22860	COG1132	(ABC) transporter
EXW46_22875	COG2258	MOSC domain
EXW46_22885	COG0583	DNA-binding transcription factor activity
EXW46_22925	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXW46_22930	COG0583	DNA-binding transcription factor activity
EXW46_22940	COG0561	phosphatase activity
EXW46_22990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_23000	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXW46_23035	COG1247	-acetyltransferase
EXW46_23065	COG0697	spore germination
EXW46_23075	COG1309	transcriptional regulator
EXW46_23080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXW46_23095	COG1846	Transcriptional regulator
EXW46_23140	COG1234	tRNA 3'-trailer cleavage
EXW46_23160	COG1253	flavin adenine dinucleotide binding
EXW46_23185	COG0028	Belongs to the TPP enzyme family
EXW46_23200	COG0596	Alpha beta hydrolase
EXW46_23210	COG1136	(ABC) transporter
EXW46_23220	COG3655	Transcriptional regulator
EXW46_23225	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXW46_23230	COG1187	pseudouridine synthase activity
EXW46_23245	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_23260	COG1115	amino acid carrier protein
EXW46_23265	COG2318	DinB family
EXW46_23275	COG0776	regulation of translation
EXW46_23290	COG2814	Major facilitator Superfamily
EXW46_23295	COG3251	PFAM MbtH domain protein
EXW46_23300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXW46_23305	COG1535	isochorismatase
EXW46_23305	COG3433	isochorismatase activity
EXW46_23310	COG1021	2,3-dihydroxybenzoate-AMP ligase
EXW46_23315	COG1169	isochorismate synthase
EXW46_23320	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_23325	COG2223	nitrite transmembrane transporter activity
EXW46_23340	COG0419	ATPase involved in DNA repair
EXW46_23345	COG0420	3'-5' exonuclease activity
EXW46_23360	COG1024	Enoyl-CoA hydratase
EXW46_23365	COG1280	lysine exporter protein (LysE YggA)
EXW46_23370	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_23375	COG2084	Dehydrogenase
EXW46_23380	COG1960	acyl-CoA dehydrogenase activity
EXW46_23385	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EXW46_23390	COG2079	MmgE PrpD family protein
EXW46_23395	COG0372	Belongs to the citrate synthase family
EXW46_23405	COG2814	Major facilitator Superfamily
EXW46_23415	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_23415	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW46_23435	COG1028	Short-chain dehydrogenase reductase Sdr
EXW46_23460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXW46_23510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_23515	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
EXW46_23520	COG0671	phosphoesterase, PA-phosphatase related
EXW46_23530	COG4991	sh3 domain protein
EXW46_23530	COG0515	serine threonine protein kinase
EXW46_23530	COG3064	Membrane
EXW46_23555	COG4479	Belongs to the UPF0346 family
EXW46_23565	COG1509	lysine 2,3-aminomutase activity
EXW46_23570	COG3829	transcription factor binding
EXW46_23575	COG0456	acetyltransferase
EXW46_23580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXW46_23585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXW46_23590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EXW46_23595	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_23610	COG5506	Protein of unknown function (DUF1694)
EXW46_23615	COG1012	belongs to the aldehyde dehydrogenase family
EXW46_23620	COG1253	flavin adenine dinucleotide binding
EXW46_23655	COG1174	glycine betaine transport
EXW46_23660	COG0517	IMP dehydrogenase activity
EXW46_23660	COG1125	glycine betaine transport
EXW46_23675	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EXW46_23685	COG1070	Carbohydrate kinase
EXW46_23700	COG1064	alcohol dehydrogenase
EXW46_23705	COG1737	Transcriptional regulator
EXW46_23710	COG2197	response regulator
EXW46_23715	COG2203	Gaf domain
EXW46_23715	COG4585	Histidine kinase
EXW46_23720	COG0668	transmembrane transport
EXW46_23730	COG1335	isochorismatase
EXW46_23780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW46_23785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EXW46_23790	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_23805	COG0367	asparagine synthase
EXW46_23810	COG0071	Belongs to the small heat shock protein (HSP20) family
EXW46_23815	COG1999	signal sequence binding
EXW46_23820	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXW46_23825	COG1307	EDD domain protein, DegV family
EXW46_23835	COG0805	protein transport
EXW46_23840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXW46_23845	COG1272	protein, Hemolysin III
EXW46_23860	COG0768	penicillin binding
EXW46_23875	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_23890	COG0546	phosphoglycolate phosphatase activity
EXW46_23900	COG4473	ABC transporter
EXW46_23905	COG1131	(ABC) transporter
EXW46_23915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXW46_23920	COG0456	acetyltransferase
EXW46_23930	COG1794	racemase activity, acting on amino acids and derivatives
EXW46_23935	COG1454	alcohol dehydrogenase
EXW46_23940	COG2610	gluconate transmembrane transporter activity
EXW46_23970	COG0733	neurotransmitter:sodium symporter activity
EXW46_23975	COG0017	Asparaginyl-tRNA synthetase
EXW46_24035	COG0018	arginyl-trna synthetase
EXW46_24040	COG2136	Putative SAM-dependent methyltransferase
EXW46_24040	COG2521	methyltransferase
EXW46_24055	COG1413	lyase activity
EXW46_24075	COG0488	(ABC) transporter
EXW46_24080	COG1418	mRNA catabolic process
EXW46_24090	COG2359	stage V sporulation protein S
EXW46_24120	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
EXW46_24125	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW46_24130	COG2146	nitrite reductase [NAD(P)H] activity
EXW46_24135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXW46_24135	COG1587	Uroporphyrinogen-III synthase
EXW46_24145	COG1648	precorrin-2 dehydrogenase activity
EXW46_24155	COG2223	nitrite transmembrane transporter activity
EXW46_24165	COG0314	molybdopterin synthase activity
EXW46_24170	COG0303	'Molybdopterin
EXW46_24175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_24180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXW46_24185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXW46_24190	COG2181	nitrate reductase activity
EXW46_24195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
EXW46_24200	COG1140	nitrate reductase beta subunit
EXW46_24205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
EXW46_24210	COG0714	Associated with various cellular activities
EXW46_24215	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
EXW46_24220	COG1305	Transglutaminase-like
EXW46_24225	COG0386	Belongs to the glutathione peroxidase family
EXW46_24235	COG0426	domain, Protein
EXW46_24235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXW46_24260	COG1595	DNA-templated transcription, initiation
EXW46_24265	COG0604	alcohol dehydrogenase
EXW46_24300	COG2226	methyltransferase
EXW46_24325	COG3874	Sporulation protein YtfJ
EXW46_24410	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW46_24445	COG0456	acetyltransferase
EXW46_24470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_24475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_24480	COG1819	glycosyl
EXW46_24500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXW46_24510	COG0561	phosphatase activity
EXW46_24520	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_24535	COG2211	Major facilitator Superfamily
EXW46_24545	COG0494	nUDIX hydrolase
EXW46_24550	COG1876	peptidase activity
EXW46_24560	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXW46_24580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXW46_24585	COG1114	Component of the transport system for branched-chain amino acids
EXW46_24600	COG1253	flavin adenine dinucleotide binding
EXW46_24605	COG2839	Protein conserved in bacteria
EXW46_24610	COG0702	epimerase
EXW46_24630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_24640	COG1607	acyl-coa hydrolase
EXW46_24645	COG3689	TIGRFAM TIGR03943 family protein
EXW46_24650	COG0701	Predicted permease
EXW46_24660	COG2244	polysaccharide biosynthetic process
EXW46_24665	COG0586	Pfam SNARE associated Golgi protein
EXW46_24670	COG1051	belongs to the nudix hydrolase family
EXW46_24675	COG5337	Spore coat protein CotH
EXW46_24695	COG0346	lactoylglutathione lyase activity
EXW46_24700	COG4166	transmembrane transport
EXW46_24710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EXW46_24715	COG1902	pentaerythritol trinitrate reductase activity
EXW46_24725	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXW46_24730	COG0456	acetyltransferase
EXW46_24735	COG0523	cobalamin synthesis protein
EXW46_24740	COG4989	oxidoreductase activity
EXW46_24745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_24750	COG1231	oxidoreductase activity
EXW46_24760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXW46_24775	COG0783	Belongs to the Dps family
EXW46_24780	COG3949	Membrane
EXW46_24820	COG2814	Major facilitator Superfamily
EXW46_24825	COG0667	Aldo Keto reductase
EXW46_24830	COG0640	Transcriptional regulator
EXW46_24835	COG1404	Belongs to the peptidase S8 family
EXW46_24840	COG2002	toxin-antitoxin pair type II binding
EXW46_24845	COG0577	efflux transmembrane transporter activity
EXW46_24850	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXW46_24880	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXW46_24890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_24895	COG1279	arginine transmembrane transporter activity
EXW46_24900	COG2814	Major facilitator Superfamily
EXW46_24910	COG1082	Xylose isomerase domain protein TIM barrel
EXW46_24920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXW46_24940	COG1247	-acetyltransferase
EXW46_24945	COG1285	pathogenesis
EXW46_24960	COG5002	protein histidine kinase activity
EXW46_24965	COG0745	RESPONSE REGULATOR receiver
EXW46_24975	COG1316	TRANSCRIPTIONal
EXW46_24990	COG0083	homoserine kinase activity
EXW46_25000	COG0460	homoserine dehydrogenase
EXW46_25040	COG0300	oxidoreductase activity
EXW46_25045	COG5002	protein histidine kinase activity
EXW46_25050	COG0745	RESPONSE REGULATOR receiver
EXW46_25055	COG1132	(ABC) transporter
EXW46_25065	COG0791	NLP P60 protein
EXW46_25065	COG1388	LysM domain
EXW46_25075	COG1686	Belongs to the peptidase S11 family
EXW46_25105	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EXW46_25110	COG4988	ABC transporter
EXW46_25115	COG1294	oxidase, subunit
EXW46_25120	COG1271	oxidase subunit
EXW46_25130	COG0346	lactoylglutathione lyase activity
EXW46_25145	COG1942	4-Oxalocrotonate Tautomerase
EXW46_25155	COG0583	DNA-binding transcription factor activity
EXW46_25175	COG0411	ABC transporter
EXW46_25185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXW46_25190	COG2030	dehydratase
EXW46_25195	COG0318	PFAM AMP-dependent synthetase and ligase
EXW46_25205	COG0523	cobalamin synthesis protein
EXW46_25230	COG1231	oxidoreductase activity
EXW46_25245	COG0628	permease
EXW46_25275	COG0778	Nitroreductase
EXW46_25280	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EXW46_25285	COG1959	2 iron, 2 sulfur cluster binding
EXW46_25290	COG0583	DNA-binding transcription factor activity
EXW46_25295	COG0697	spore germination
EXW46_25305	COG4549	nuclear export factor GLE1
EXW46_25310	COG2372	response to copper ion
EXW46_25310	COG1276	copper resistance
EXW46_25320	COG1114	Component of the transport system for branched-chain amino acids
EXW46_25340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EXW46_25355	COG2132	Multicopper oxidase
EXW46_25360	COG0006	proline dipeptidase activity
EXW46_25390	COG4846	Membrane protein involved in cytochrome C biogenesis
EXW46_25405	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXW46_25410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
EXW46_25415	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EXW46_25425	COG2390	Transcriptional regulator
EXW46_25430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EXW46_25450	COG1280	lysine exporter protein (LysE YggA)
EXW46_25470	COG0531	amino acid
EXW46_25475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXW46_25485	COG1054	Belongs to the UPF0176 family
EXW46_25490	COG1914	H( )-stimulated, divalent metal cation uptake system
EXW46_25500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXW46_25505	COG4166	transmembrane transport
EXW46_25545	COG3384	dioxygenase
EXW46_25550	COG2814	Major facilitator Superfamily
EXW46_25575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXW46_25580	COG0129	dihydroxy-acid dehydratase activity
EXW46_25590	COG0745	RESPONSE REGULATOR receiver
EXW46_25595	COG5002	protein histidine kinase activity
EXW46_25605	COG2132	Multicopper oxidase
EXW46_25610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXW46_25625	COG2323	membrane
EXW46_25630	COG5566	PFAM Mor transcription activator
EXW46_25640	COG0733	neurotransmitter:sodium symporter activity
EXW46_25645	COG2244	polysaccharide biosynthetic process
EXW46_25660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
EXW46_25665	COG2223	nitrite transmembrane transporter activity
EXW46_25670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXW46_25685	COG0477	Major facilitator Superfamily
EXW46_25700	COG1695	Transcriptional regulator
EXW46_25710	COG1966	Carbon starvation protein
EXW46_25725	COG2814	Major facilitator Superfamily
EXW46_25740	COG1051	belongs to the nudix hydrolase family
EXW46_25785	COG2502	aspartate--ammonia ligase
EXW46_25800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXW46_25810	COG1846	Transcriptional regulator
EXW46_25815	COG0784	Response regulator, receiver
EXW46_25820	COG4191	Histidine kinase
EXW46_25825	COG0281	malic enzyme
EXW46_25830	COG1027	Aspartate ammonia-lyase
EXW46_25840	COG0528	UMP kinase activity
EXW46_25845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXW46_25860	COG1131	(ABC) transporter
EXW46_25900	COG2733	membrane
EXW46_25905	COG3048	D-serine ammonia-lyase activity
EXW46_25920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXW46_25925	COG0785	Cytochrome C biogenesis protein
EXW46_25945	COG3340	Belongs to the peptidase S51 family
EXW46_25950	COG0534	Mate efflux family protein
EXW46_25980	COG1757	Na H antiporter
EXW46_25985	COG0438	transferase activity, transferring glycosyl groups
EXW46_25985	COG1216	Glycosyl transferase, family 2
EXW46_26005	COG0697	spore germination
EXW46_26010	COG1802	Transcriptional regulator
EXW46_26040	COG0367	asparagine synthase
EXW46_26070	COG0406	alpha-ribazole phosphatase activity
EXW46_26105	COG1234	tRNA 3'-trailer cleavage
EXW46_26120	COG3842	ATPase activity
EXW46_26125	COG0583	DNA-binding transcription factor activity
EXW46_26135	COG2814	Major facilitator Superfamily
EXW46_26150	COG2329	Antibiotic biosynthesis monooxygenase
EXW46_26190	COG4786	Flagellar basal body rod
EXW46_26195	COG1419	protein localization to endoplasmic reticulum
EXW46_26200	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW46_26205	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXW46_26215	COG1987	bacterial-type flagellum assembly
EXW46_26220	COG1338	Plays a role in the flagellum-specific transport system
EXW46_26230	COG1776	CheC inhibitor of MCP methylation
EXW46_26230	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_26235	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_26245	COG0741	lytic transglycosylase activity
EXW46_26250	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW46_26255	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW46_26260	COG0489	protein tyrosine kinase activity
EXW46_26275	COG0314	molybdopterin synthase activity
EXW46_26280	COG0303	'Molybdopterin
EXW46_26285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXW46_26290	COG2116	formate transmembrane transporter activity
EXW46_26300	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXW46_26305	COG5609	conserved protein (DUF2294)
EXW46_26310	COG2427	Protein of unknown function (DUF1641)
EXW46_26320	COG3383	formate dehydrogenase (NAD+) activity
EXW46_26330	COG0861	Integral membrane protein TerC family
EXW46_26355	COG0784	Response regulator, receiver
EXW46_26355	COG0835	chemotaxis
EXW46_26390	COG1157	protein secretion by the type III secretion system
EXW46_26400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_26405	COG1766	The M ring may be actively involved in energy transduction
EXW46_26415	COG1558	bacterial-type flagellum-dependent cell motility
EXW46_26420	COG1815	bacterial-type flagellum-dependent cell motility
EXW46_26440	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EXW46_26445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXW46_26450	COG1256	bacterial-type flagellum assembly
EXW46_26470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXW46_26485	COG1776	CheC inhibitor of MCP methylation
EXW46_26485	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXW46_26490	COG0643	Histidine kinase
EXW46_26490	COG2198	Histidine kinase
EXW46_26495	COG2201	protein-glutamate methylesterase activity
EXW46_26500	COG1360	Flagellar Motor Protein
EXW46_26505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXW46_26515	COG1923	regulation of RNA biosynthetic process
EXW46_26535	COG2814	Major facilitator Superfamily
EXW46_26570	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXW46_26575	COG2323	membrane
EXW46_26585	COG0789	Transcriptional regulator
EXW46_26585	COG4978	Transcriptional regulator
EXW46_26590	COG0475	glutathione-regulated potassium exporter activity
EXW46_26600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EXW46_26605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXW46_26610	COG3162	membrane
EXW46_26625	COG1280	lysine exporter protein (LysE YggA)
EXW46_26630	COG3403	YqcI/YcgG family
EXW46_26665	COG0328	RNA-DNA hybrid ribonuclease activity
EXW46_26685	COG0454	-acetyltransferase
EXW46_26700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EXW46_26740	COG2897	thiosulfate sulfurtransferase activity
EXW46_26750	COG0456	acetyltransferase
EXW46_26760	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW46_26765	COG2311	Membrane
EXW46_26770	COG2233	PERMEase
EXW46_26775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXW46_26780	COG0024	Methionine aminopeptidase
EXW46_26790	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXW46_26795	COG1199	ATP-dependent helicase activity
EXW46_26805	COG0116	Belongs to the methyltransferase superfamily
EXW46_26815	COG3599	regulation of cell shape
EXW46_26820	COG4474	Belongs to the UPF0398 family
EXW46_26855	COG3331	DNA recombination
EXW46_26860	COG4499	WXG100 protein secretion system (Wss), protein YukC
EXW46_26860	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_26870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXW46_26875	COG3935	DnaD domain protein
EXW46_26895	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EXW46_26895	COG1199	ATP-dependent helicase activity
EXW46_26905	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXW46_26910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXW46_26920	COG0617	tRNA 3'-terminal CCA addition
EXW46_26925	COG0438	transferase activity, transferring glycosyl groups
EXW46_26930	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EXW46_26935	COG1803	Methylglyoxal synthase
EXW46_26940	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXW46_26945	COG1694	Mazg nucleotide pyrophosphohydrolase
EXW46_26950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
EXW46_26960	COG2738	Putative neutral zinc metallopeptidase
EXW46_26975	COG4347	Protein of unknown function (DUF1405)
EXW46_26990	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXW46_27005	COG5582	Belongs to the UPF0302 family
EXW46_27010	COG0457	Tetratricopeptide repeat
EXW46_27015	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXW46_27025	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXW46_27040	COG0142	geranyltranstransferase activity
EXW46_27045	COG2226	methyltransferase
EXW46_27050	COG0142	geranyltranstransferase activity
EXW46_27055	COG0302	gtp cyclohydrolase
EXW46_27065	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
EXW46_27085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXW46_27090	COG1160	GTP binding
EXW46_27125	COG1304	FMN binding
EXW46_27135	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EXW46_27140	COG0252	asparaginase activity
EXW46_27145	COG0492	ferredoxin-NADP+ reductase activity
EXW46_27165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXW46_27180	COG1408	metallophosphoesterase
EXW46_27190	COG1266	CAAX protease self-immunity
EXW46_27195	COG0514	ATP-dependent DNA helicase (RecQ)
EXW46_27200	COG4955	Helix-turn-helix domain
EXW46_27210	COG1141	Ferredoxin
EXW46_27215	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
EXW46_27225	COG4942	peptidase
EXW46_27230	COG2096	Adenosyltransferase
EXW46_27235	COG5002	protein histidine kinase activity
EXW46_27240	COG0745	RESPONSE REGULATOR receiver
EXW46_27245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXW46_27250	COG1333	cytochrome c biogenesis protein
EXW46_27260	COG1187	pseudouridine synthase activity
EXW46_27265	COG0700	Nucleoside recognition
EXW46_27270	COG2715	membrane protein required for spore maturation
EXW46_27275	COG1686	Belongs to the peptidase S11 family
EXW46_27280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXW46_27295	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EXW46_27295	COG0392	lysyltransferase activity
EXW46_27310	COG5002	protein histidine kinase activity
EXW46_27315	COG0582	viral genome integration into host DNA
EXW46_27325	COG1801	Protein of unknown function DUF72
EXW46_27330	COG3852	Histidine kinase
EXW46_27345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXW46_27350	COG1392	Phosphate transport regulator
EXW46_27355	COG0306	phosphate transporter
EXW46_27360	COG0730	response to heat
EXW46_27400	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXW46_27410	COG1114	Component of the transport system for branched-chain amino acids
EXW46_27420	COG2197	response regulator
EXW46_27425	COG4585	Histidine kinase
EXW46_27430	COG4758	membrane
EXW46_27450	COG1757	Na H antiporter
EXW46_27470	COG0733	neurotransmitter:sodium symporter activity
EXW46_27475	COG1648	precorrin-2 dehydrogenase activity
EXW46_27495	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXW46_27540	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EXW46_27540	COG2508	Transcriptional regulator
EXW46_27545	COG0686	Belongs to the AlaDH PNT family
EXW46_27575	COG0745	RESPONSE REGULATOR receiver
EXW46_27585	COG0739	heme binding
EXW46_27630	COG1073	alpha beta
EXW46_27635	COG2732	(Barnase) inhibitor
EXW46_27705	COG0531	amino acid
EXW46_27715	COG3338	carbonate dehydratase activity
EXW46_27725	COG5002	protein histidine kinase activity
EXW46_27755	COG5002	protein histidine kinase activity
EXW46_27780	COG3227	Zinc metalloprotease (Elastase)
EXW46_27815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW46_27825	COG2707	UPF0756 membrane protein
EXW46_27835	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXW46_27850	COG1136	(ABC) transporter
EXW46_27860	COG5002	protein histidine kinase activity
EXW46_27865	COG3842	ATPase activity
EXW46_27890	COG0395	ABC-type sugar transport system, permease component
EXW46_27895	COG1175	transmembrane transport
EXW46_27900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXW46_27905	COG1279	arginine transmembrane transporter activity
EXW46_27930	COG0745	RESPONSE REGULATOR receiver
EXW46_27950	COG1696	Membrane protein involved in D-alanine export
EXW46_27970	COG3739	integral membrane protein
EXW46_27975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EXW46_27980	COG1131	(ABC) transporter
EXW46_27990	COG3655	Transcriptional regulator
EXW46_28025	COG0640	Transcriptional regulator
EXW46_28055	COG0823	Involved in the tonB-independent uptake of proteins
EXW46_28060	COG5002	protein histidine kinase activity
EXW46_28065	COG0745	RESPONSE REGULATOR receiver
EXW46_28115	COG2814	Major facilitator Superfamily
EXW46_28120	COG0577	efflux transmembrane transporter activity
EXW46_28120	COG1136	(ABC) transporter
EXW46_28130	COG2205	protein histidine kinase activity
EXW46_28135	COG0745	RESPONSE REGULATOR receiver
EXW46_28155	COG1136	(ABC) transporter
EXW46_28160	COG0577	efflux transmembrane transporter activity
EXW46_28180	COG0659	secondary active sulfate transmembrane transporter activity
EXW46_28195	COG2824	Alkylphosphonate utilization operon protein PhnA
EXW46_28245	COG3493	citrate carrier protein
EXW46_28250	COG4565	transcriptional regulatory protein
EXW46_28255	COG3290	protein histidine kinase activity
EXW46_28300	COG0753	catalase activity
EXW46_28325	COG0825	malonyl-CoA metabolic process
EXW46_28370	COG2124	cytochrome p450
EXW46_28470	COG0529	Catalyzes the synthesis of activated sulfate
EXW46_28475	COG2046	Belongs to the sulfate adenylyltransferase family
EXW46_28480	COG0175	sulfate reduction
EXW46_28490	COG0019	diaminopimelate decarboxylase activity
EXW46_28500	COG1368	sulfuric ester hydrolase activity
EXW46_28505	COG1183	phosphatidylcholine synthase activity
EXW46_28520	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EXW46_28525	COG0140	phosphoribosyl-ATP diphosphatase activity
EXW46_28535	COG0107	imidazoleglycerol-phosphate synthase activity
EXW46_28540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXW46_28545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXW46_28550	COG0131	Imidazoleglycerol-phosphate dehydratase
EXW46_28560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXW46_28565	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXW46_28575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXW46_28585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXW46_28595	COG0440	acetolactate synthase activity
EXW46_28600	COG0028	Belongs to the TPP enzyme family
EXW46_28605	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EXW46_28630	COG3874	Sporulation protein YtfJ
EXW46_28640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EXW46_28665	COG2868	ribosomal protein