locus-tag	class	description
ER45_000005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ER45_000010	COG0592	DNA-directed DNA polymerase activity
ER45_000015	COG2501	S4 domain
ER45_000020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ER45_000025	COG0187	DNA topoisomerase II activity
ER45_000030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ER45_000065	COG0516	GMP reductase activity
ER45_000065	COG0517	IMP dehydrogenase activity
ER45_000070	COG1686	Belongs to the peptidase S11 family
ER45_000080	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ER45_000100	COG1428	Deoxynucleoside kinase
ER45_000105	COG1428	Deoxynucleoside kinase
ER45_000110	COG1335	isochorismatase
ER45_000115	COG0590	tRNA wobble adenosine to inosine editing
ER45_000125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ER45_000130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ER45_000135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ER45_000180	COG1982	Orn Lys Arg decarboxylase major
ER45_000185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ER45_000190	COG0470	DNA polymerase III
ER45_000195	COG1774	PSP1 C-terminal conserved region
ER45_000200	COG4467	Involved in initiation control of chromosome replication
ER45_000205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ER45_000220	COG2002	toxin-antitoxin pair type II binding
ER45_000230	COG0084	hydrolase, TatD family'
ER45_000240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ER45_000250	COG4466	Protein conserved in bacteria
ER45_000260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ER45_000265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ER45_000270	COG0251	oxidation-reduction process
ER45_000275	COG2088	sporulation resulting in formation of a cellular spore
ER45_000280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ER45_000300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ER45_000305	COG2002	toxin-antitoxin pair type II binding
ER45_000310	COG2244	polysaccharide biosynthetic process
ER45_000315	COG3956	TIGRFAM MazG family protein
ER45_000320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ER45_000340	COG1098	S1 RNA binding domain
ER45_000355	COG2208	phosphoserine phosphatase activity
ER45_000365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ER45_000375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ER45_000380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ER45_000385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ER45_000390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ER45_000395	COG0512	Glutamine amidotransferase of anthranilate synthase
ER45_000400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ER45_000410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ER45_000415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ER45_000420	COG1396	sequence-specific DNA binding
ER45_000425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ER45_000430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ER45_000515	COG3880	PFAM UvrB UvrC protein
ER45_000520	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ER45_000525	COG0542	response to heat
ER45_000530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ER45_000535	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ER45_000540	COG4956	integral membrane protein (PIN domain superfamily)
ER45_000545	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ER45_000555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ER45_000560	COG1045	serine acetyltransferase
ER45_000565	COG0215	cysteine-tRNA ligase activity
ER45_000575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ER45_000580	COG3688	RNA-binding protein containing a PIN domain
ER45_000590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ER45_000595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ER45_000600	COG0250	Participates in transcription elongation, termination and antitermination
ER45_000605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ER45_000610	COG0081	regulation of translation
ER45_000615	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ER45_000620	COG0222	ribosome binding
ER45_000625	COG2813	Specifically methylates the guanine in position
ER45_000630	COG0085	RNA polymerase activity
ER45_000635	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ER45_000640	COG1358	cellular component organization or biogenesis
ER45_000645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ER45_000660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ER45_000665	COG0051	transcription antitermination factor activity, RNA binding
ER45_000670	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ER45_000675	COG0088	Forms part of the polypeptide exit tunnel
ER45_000680	COG0089	rRNA binding
ER45_000685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ER45_000690	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ER45_000695	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ER45_000710	COG0255	Belongs to the universal ribosomal protein uL29 family
ER45_000715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ER45_000725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ER45_000730	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ER45_000740	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ER45_000750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ER45_000760	COG1841	ribosomal large subunit assembly
ER45_000765	COG0200	Binds to the 23S rRNA
ER45_000775	COG0563	adenylate kinase activity
ER45_000780	COG0024	Methionine aminopeptidase
ER45_000790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ER45_000795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ER45_000800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ER45_000825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ER45_000835	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ER45_000840	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ER45_000855	COG0489	protein tyrosine kinase activity
ER45_000865	COG2194	sulfuric ester hydrolase activity
ER45_000870	COG0726	polysaccharide deacetylase
ER45_000950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ER45_000990	COG2011	ABC-type metal ion transport system permease component
ER45_001000	COG1464	Belongs to the NlpA lipoprotein family
ER45_001005	COG0604	alcohol dehydrogenase
ER45_001015	COG0277	FAD linked oxidase domain protein
ER45_001020	COG2271	Major facilitator Superfamily
ER45_001030	COG2814	Major facilitator Superfamily
ER45_001045	COG0601	transmembrane transport
ER45_001050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ER45_001055	COG0444	Belongs to the ABC transporter superfamily
ER45_001060	COG4608	Belongs to the ABC transporter superfamily
ER45_001065	COG4166	transmembrane transport
ER45_001075	COG2207	Transcriptional regulator
ER45_001090	COG4166	transmembrane transport
ER45_001095	COG4166	transmembrane transport
ER45_001100	COG0656	L-ascorbic acid biosynthetic process
ER45_001105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ER45_001120	COG4149	molybdate abc transporter
ER45_001125	COG0725	ABC transporter, periplasmic molybdate-binding protein
ER45_001130	COG1910	domain protein
ER45_001160	COG0204	Acyl-transferase
ER45_001170	COG1609	Transcriptional regulator
ER45_001180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_001195	COG5298	Protein conserved in bacteria
ER45_001215	COG0488	(ABC) transporter
ER45_001220	COG4585	Histidine kinase
ER45_001225	COG2197	response regulator
ER45_001230	COG1131	(ABC) transporter
ER45_001240	COG0842	Transport permease protein
ER45_001260	COG0601	transmembrane transport
ER45_001270	COG0444	Belongs to the ABC transporter superfamily
ER45_001275	COG4608	Belongs to the ABC transporter superfamily
ER45_001280	COG0561	phosphatase activity
ER45_001305	COG3185	4-Hydroxyphenylpyruvate dioxygenase
ER45_001310	COG0179	Fumarylacetoacetate (FAA) hydrolase
ER45_001325	COG2814	Major facilitator Superfamily
ER45_001335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ER45_001345	COG4294	response to UV
ER45_001350	COG0705	Rhomboid family
ER45_001355	COG0736	holo-[acyl-carrier-protein] synthase activity
ER45_001360	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ER45_001370	COG0864	Transcriptional regulator
ER45_001375	COG2337	Toxic component of a toxin-antitoxin (TA) module
ER45_001480	COG0802	atpase or kinase
ER45_001485	COG1214	PFAM Peptidase M22, glycoprotease
ER45_001490	COG0456	acetyltransferase
ER45_001500	COG0488	(ABC) transporter
ER45_001505	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ER45_001520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ER45_001525	COG0459	protein refolding
ER45_001530	COG0519	Catalyzes the synthesis of GMP from XMP
ER45_001530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ER45_001535	COG2252	PERMEase
ER45_001545	COG5002	protein histidine kinase activity
ER45_001565	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ER45_001625	COG2205	protein histidine kinase activity
ER45_001630	COG0745	RESPONSE REGULATOR receiver
ER45_001680	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ER45_001685	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ER45_001690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ER45_001695	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ER45_001700	COG0047	phosphoribosylformylglycinamidine synthase activity
ER45_001705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ER45_001715	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ER45_001720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ER45_001725	COG0138	bifunctional purine biosynthesis protein purh
ER45_001730	COG0151	Belongs to the GarS family
ER45_001755	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ER45_001760	COG0210	DNA helicase
ER45_001765	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ER45_001770	COG4851	CamS sex pheromone cAM373 precursor
ER45_001780	COG1012	belongs to the aldehyde dehydrogenase family
ER45_001785	COG1335	isochorismatase
ER45_001795	COG2011	ABC-type metal ion transport system permease component
ER45_001800	COG1464	Belongs to the NlpA lipoprotein family
ER45_001815	COG0003	Pfam Anion-transporting ATPase
ER45_001820	COG1846	Transcriptional regulator
ER45_001825	COG4682	membrane
ER45_001835	COG0154	amidase activity
ER45_001840	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ER45_001845	COG1597	lipid kinase activity
ER45_001850	COG0546	phosphoglycolate phosphatase activity
ER45_001855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ER45_001865	COG1012	belongs to the aldehyde dehydrogenase family
ER45_001870	COG2076	Multidrug Resistance protein
ER45_001875	COG2309	aminopeptidase activity
ER45_001890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_001900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ER45_001905	COG5002	protein histidine kinase activity
ER45_001910	COG4807	Protein conserved in bacteria
ER45_001935	COG1757	Na H antiporter
ER45_001940	COG1473	amidohydrolase
ER45_001955	COG0450	alkyl hydroperoxide reductase
ER45_001965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ER45_001975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_001980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_001985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_001990	COG0492	ferredoxin-NADP+ reductase activity
ER45_002000	COG0166	Belongs to the GPI family
ER45_002025	COG5002	protein histidine kinase activity
ER45_002045	COG3541	Predicted nucleotidyltransferase
ER45_002050	COG2814	Major facilitator Superfamily
ER45_002055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ER45_002055	COG0723	plastoquinol--plastocyanin reductase activity
ER45_002065	COG0765	amino acid transport
ER45_002070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ER45_002080	COG0840	transmembrane signaling receptor activity
ER45_002085	COG0277	FAD linked oxidase domain protein
ER45_002095	COG1263	PTS System
ER45_002095	COG2190	(PTS) system
ER45_002095	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ER45_002115	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ER45_002120	COG0352	thiamine-phosphate diphosphorylase activity
ER45_002125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
ER45_002140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ER45_002145	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ER45_002150	COG1116	anion transmembrane transporter activity
ER45_002155	COG0488	(ABC) transporter
ER45_002200	COG2270	Major facilitator Superfamily
ER45_002230	COG2310	stress, protein
ER45_002235	COG2310	stress, protein
ER45_002240	COG2310	stress, protein
ER45_002245	COG0861	Integral membrane protein TerC family
ER45_002255	COG3853	Toxic anion resistance protein (TelA)
ER45_002265	COG4840	Belongs to the UPF0435 family
ER45_002270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ER45_002280	COG1295	ribonuclease BN
ER45_002285	COG2217	Heavy metal translocating P-type atpase
ER45_002310	COG0586	Pfam SNARE associated Golgi protein
ER45_002325	COG3871	stress protein (general stress protein 26)
ER45_002330	COG0387	Pfam Sodium calcium exchanger
ER45_002340	COG0535	radical SAM domain protein
ER45_002360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ER45_002380	COG3829	transcription factor binding
ER45_002390	COG0833	amino acid
ER45_002395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ER45_002415	COG2066	Belongs to the glutaminase family
ER45_002420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ER45_002420	COG1263	PTS System
ER45_002425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ER45_002445	COG1216	Glycosyl transferase, family 2
ER45_002455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ER45_002455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ER45_002460	COG0463	Glycosyl transferase, family 2
ER45_002475	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
ER45_002480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ER45_002495	COG1228	amidohydrolase
ER45_002500	COG1090	epimerase
ER45_002505	COG2137	regulation of response to DNA damage stimulus
ER45_002530	COG1988	membrane-bound metal-dependent
ER45_002535	COG1194	a g-specific adenine glycosylase
ER45_002555	COG3557	Belongs to the UPF0374 family
ER45_002565	COG4129	membrane
ER45_002575	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ER45_002580	COG4555	ABC transporter
ER45_002600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ER45_002605	COG0735	belongs to the Fur family
ER45_002725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
ER45_002730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ER45_002750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ER45_002760	COG2766	serine protein kinase
ER45_002765	COG2718	Belongs to the UPF0229 family
ER45_002780	COG1585	Membrane protein implicated in regulation of membrane protease activity
ER45_002785	COG2268	Band 7 protein
ER45_002795	COG3290	protein histidine kinase activity
ER45_002800	COG4565	transcriptional regulatory protein
ER45_002805	COG2851	Citrate transporter
ER45_002830	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ER45_002840	COG1175	transmembrane transport
ER45_002845	COG0395	ABC-type sugar transport system, permease component
ER45_002855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ER45_002860	COG0745	RESPONSE REGULATOR receiver
ER45_002865	COG5002	protein histidine kinase activity
ER45_002875	COG4990	cell redox homeostasis
ER45_002885	COG3290	protein histidine kinase activity
ER45_002890	COG4565	transcriptional regulatory protein
ER45_002895	COG3493	citrate carrier protein
ER45_002900	COG0281	malic enzyme
ER45_002915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ER45_002925	COG5002	protein histidine kinase activity
ER45_002930	COG0745	RESPONSE REGULATOR receiver
ER45_002935	COG0456	acetyltransferase
ER45_002940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ER45_002945	COG3383	formate dehydrogenase (NAD+) activity
ER45_002950	COG2427	Protein of unknown function (DUF1641)
ER45_002965	COG0531	amino acid
ER45_002975	COG0640	Transcriptional regulator
ER45_002980	COG2217	Heavy metal translocating P-type atpase
ER45_003000	COG3227	Zinc metalloprotease (Elastase)
ER45_003020	COG2720	vancomycin resistance protein
ER45_003025	COG1316	TRANSCRIPTIONal
ER45_003030	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_003035	COG0346	lactoylglutathione lyase activity
ER45_003040	COG1253	flavin adenine dinucleotide binding
ER45_003045	COG1027	Aspartate ammonia-lyase
ER45_003050	COG1620	l-lactate permease
ER45_003055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ER45_003070	COG3104	oligopeptide transport
ER45_003075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_003085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_003100	COG0156	8-amino-7-oxononanoate synthase activity
ER45_003105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ER45_003115	COG4548	von Willebrand factor, type A
ER45_003120	COG0714	Associated with various cellular activities
ER45_003140	COG0531	amino acid
ER45_003145	COG2188	Transcriptional regulator
ER45_003150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ER45_003150	COG1263	PTS System
ER45_003155	COG0366	Alpha amylase catalytic
ER45_003175	COG0697	spore germination
ER45_003180	COG4585	Histidine kinase
ER45_003185	COG2197	response regulator
ER45_003205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ER45_003215	COG1126	abc transporter atp-binding protein
ER45_003220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ER45_003230	COG0765	amino acid transport
ER45_003235	COG0833	amino acid
ER45_003245	COG2378	regulation of single-species biofilm formation
ER45_003250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ER45_003255	COG5002	protein histidine kinase activity
ER45_003270	COG0659	secondary active sulfate transmembrane transporter activity
ER45_003285	COG2271	Major facilitator Superfamily
ER45_003290	COG1846	Transcriptional regulator
ER45_003295	COG0477	Major facilitator Superfamily
ER45_003300	COG1609	Transcriptional regulator
ER45_003305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ER45_003310	COG1869	D-ribose catabolic process
ER45_003320	COG1172	Belongs to the binding-protein-dependent transport system permease family
ER45_003325	COG1879	ABC-type sugar transport system periplasmic component
ER45_003355	COG1063	alcohol dehydrogenase
ER45_003370	COG3568	Endonuclease Exonuclease Phosphatase
ER45_003400	COG0840	transmembrane signaling receptor activity
ER45_003405	COG3583	domain protein
ER45_003405	COG3584	3D domain protein
ER45_003410	COG1476	TRANSCRIPTIONal
ER45_003430	COG3104	oligopeptide transport
ER45_003450	COG1113	amino acid transport
ER45_003455	COG2252	PERMEase
ER45_003470	COG2153	protein acetylation
ER45_003480	COG0475	glutathione-regulated potassium exporter activity
ER45_003480	COG0569	domain protein
ER45_003490	COG1845	cytochrome c oxidase, subunit III
ER45_003495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ER45_003505	COG0833	amino acid
ER45_003510	COG4990	cell redox homeostasis
ER45_003525	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ER45_003530	COG0697	spore germination
ER45_003535	COG0531	amino acid
ER45_003545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ER45_003550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ER45_003560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ER45_003565	COG0573	inorganic phosphate transmembrane transporter activity
ER45_003570	COG0581	inorganic phosphate transmembrane transporter activity
ER45_003580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ER45_003585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ER45_003710	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ER45_003725	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_003725	COG3103	Sh3 type 3 domain protein
ER45_003725	COG4991	sh3 domain protein
ER45_003730	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ER45_003735	COG1116	anion transmembrane transporter activity
ER45_003740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ER45_003745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ER45_003750	COG0352	thiamine-phosphate diphosphorylase activity
ER45_003755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ER45_003760	COG2104	thiamine diphosphate biosynthetic process
ER45_003765	COG2022	thiamine diphosphate biosynthetic process
ER45_003770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ER45_003775	COG0351	phosphomethylpyrimidine kinase
ER45_003800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ER45_003805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ER45_003810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ER45_003815	COG2205	protein histidine kinase activity
ER45_003820	COG2814	Major facilitator Superfamily
ER45_003825	COG1846	Transcriptional regulator
ER45_003845	COG1172	Belongs to the binding-protein-dependent transport system permease family
ER45_003850	COG1129	ABC transporter
ER45_003855	COG1879	ABC-type sugar transport system periplasmic component
ER45_003860	COG2252	PERMEase
ER45_003865	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_003925	COG0778	Nitroreductase
ER45_003930	COG2719	SpoVR family
ER45_003955	COG1937	Protein conserved in bacteria
ER45_003960	COG0425	Belongs to the sulfur carrier protein TusA family
ER45_003960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ER45_003965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ER45_003965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_003970	COG0425	Belongs to the sulfur carrier protein TusA family
ER45_003975	COG0425	Belongs to the sulfur carrier protein TusA family
ER45_003975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ER45_003980	COG2210	Belongs to the sulfur carrier protein TusA family
ER45_003985	COG0730	response to heat
ER45_003995	COG1316	TRANSCRIPTIONal
ER45_004000	COG0604	alcohol dehydrogenase
ER45_004005	COG1283	sodium-dependent phosphate transmembrane transporter activity
ER45_004010	COG0604	alcohol dehydrogenase
ER45_004015	COG2814	Major facilitator Superfamily
ER45_004025	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ER45_004025	COG3711	transcriptional antiterminator
ER45_004030	COG1447	Phosphotransferase system cellobiose-specific component IIA
ER45_004035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ER45_004060	COG3584	3D domain protein
ER45_004060	COG1388	LysM domain
ER45_004065	COG0577	efflux transmembrane transporter activity
ER45_004070	COG1136	(ABC) transporter
ER45_004080	COG5522	Integral membrane protein (intg_mem_TP0381)
ER45_004095	COG1114	Component of the transport system for branched-chain amino acids
ER45_004100	COG3546	catalase activity
ER45_004130	COG0586	Pfam SNARE associated Golgi protein
ER45_004160	COG0531	amino acid
ER45_004165	COG0475	glutathione-regulated potassium exporter activity
ER45_004175	COG1737	Transcriptional regulator
ER45_004180	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ER45_004185	COG1263	PTS System
ER45_004185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ER45_004195	COG2259	Doxx family
ER45_004215	COG0697	spore germination
ER45_004220	COG1522	sequence-specific DNA binding
ER45_004230	COG0300	oxidoreductase activity
ER45_004245	COG2076	Multidrug Resistance protein
ER45_004250	COG1309	transcriptional regulator
ER45_004260	COG1733	regulation of RNA biosynthetic process
ER45_004275	COG4533	DNA binding
ER45_004280	COG2211	Major facilitator Superfamily
ER45_004290	COG0693	protein deglycase activity
ER45_004300	COG0531	amino acid
ER45_004305	COG1012	belongs to the aldehyde dehydrogenase family
ER45_004310	COG1132	(ABC) transporter
ER45_004315	COG1132	(ABC) transporter
ER45_004320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ER45_004325	COG0765	amino acid transport
ER45_004330	COG1126	abc transporter atp-binding protein
ER45_004345	COG0189	ligase activity
ER45_004355	COG4399	Belongs to the UPF0754 family
ER45_004360	COG3679	Belongs to the UPF0342 family
ER45_004375	COG0028	Belongs to the TPP enzyme family
ER45_004380	COG3527	Alpha-acetolactate decarboxylase
ER45_004390	COG1216	Glycosyl transferase, family 2
ER45_004395	COG2094	Belongs to the DNA glycosylase MPG family
ER45_004400	COG0561	phosphatase activity
ER45_004415	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_004425	COG0659	secondary active sulfate transmembrane transporter activity
ER45_004440	COG0653	protein targeting
ER45_004455	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_004490	COG1024	Enoyl-CoA hydratase
ER45_004505	COG1363	Peptidase, m42
ER45_004520	COG2318	DinB family
ER45_004575	COG0601	transmembrane transport
ER45_004580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ER45_004585	COG0444	Belongs to the ABC transporter superfamily
ER45_004590	COG4608	Belongs to the ABC transporter superfamily
ER45_004645	COG5444	nuclease activity
ER45_004685	COG3290	protein histidine kinase activity
ER45_004690	COG4565	transcriptional regulatory protein
ER45_004695	COG3181	Tripartite tricarboxylate transporter family receptor
ER45_004740	COG4978	Transcriptional regulator
ER45_004740	COG0789	Transcriptional regulator
ER45_004755	COG0305	Participates in initiation and elongation during chromosome replication
ER45_004785	COG0477	Major facilitator Superfamily
ER45_004825	COG1263	PTS System
ER45_004825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ER45_004825	COG2190	(PTS) system
ER45_004830	COG2723	6-phospho-beta-galactosidase activity
ER45_004845	COG1183	phosphatidylcholine synthase activity
ER45_004905	COG2814	Major facilitator Superfamily
ER45_004910	COG0640	Transcriptional regulator
ER45_004930	COG2376	Dihydroxyacetone kinase
ER45_004940	COG2376	Dihydroxyacetone kinase
ER45_004955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ER45_004970	COG1335	isochorismatase
ER45_004975	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_004995	COG0076	glutamate decarboxylase activity
ER45_005020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ER45_005025	COG1278	Cold shock
ER45_005035	COG2409	Drug exporters of the RND superfamily
ER45_005090	COG0662	Cupin 2, conserved barrel domain protein
ER45_005110	COG0825	malonyl-CoA metabolic process
ER45_005130	COG3237	CsbD-like
ER45_005150	COG2172	sigma factor antagonist activity
ER45_005155	COG1191	sigma factor activity
ER45_005165	COG2208	phosphoserine phosphatase activity
ER45_005170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ER45_005175	COG0784	Response regulator, receiver
ER45_005175	COG2205	protein histidine kinase activity
ER45_005175	COG5002	protein histidine kinase activity
ER45_005210	COG2807	transmembrane transport
ER45_005215	COG2186	Transcriptional regulator
ER45_005220	COG4585	Histidine kinase
ER45_005225	COG2197	response regulator
ER45_005255	COG0420	3'-5' exonuclease activity
ER45_005260	COG4717	serine-type aminopeptidase activity
ER45_005265	COG3481	metal-dependent phosphohydrolase, HD sub domain
ER45_005275	COG0346	lactoylglutathione lyase activity
ER45_005280	COG0457	Tetratricopeptide repeat
ER45_005290	COG2267	carboxylic ester hydrolase activity
ER45_005300	COG2140	Oxalate decarboxylase
ER45_005315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ER45_005320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ER45_005330	COG1695	Transcriptional regulator
ER45_005340	COG1595	DNA-templated transcription, initiation
ER45_005355	COG3973	AAA domain
ER45_005360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ER45_005375	COG1846	Transcriptional regulator
ER45_005385	COG0537	adenosine 5'-monophosphoramidase activity
ER45_005390	COG1131	(ABC) transporter
ER45_005395	COG4473	ABC transporter
ER45_005405	COG0247	lactate metabolic process
ER45_005410	COG1139	Iron-sulfur cluster binding protein
ER45_005415	COG1556	Lactate utilization protein
ER45_005435	COG3402	PFAM membrane-flanked domain
ER45_005440	COG3428	Bacterial PH domain
ER45_005480	COG3402	PFAM membrane-flanked domain
ER45_005485	COG3428	Bacterial PH domain
ER45_005490	COG2329	Antibiotic biosynthesis monooxygenase
ER45_005495	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ER45_005500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ER45_005505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ER45_005530	COG1309	transcriptional regulator
ER45_005535	COG1511	domain protein
ER45_005570	COG2378	regulation of single-species biofilm formation
ER45_005575	COG1609	Transcriptional regulator
ER45_005585	COG1234	tRNA 3'-trailer cleavage
ER45_005600	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_005615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ER45_005620	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
ER45_005625	COG4208	sulfate ABC transporter
ER45_005645	COG1078	dGTPase activity
ER45_005660	COG1595	DNA-templated transcription, initiation
ER45_005665	COG3708	Transcriptional regulator
ER45_005665	COG2207	Transcriptional regulator
ER45_005670	COG2205	protein histidine kinase activity
ER45_005675	COG0745	RESPONSE REGULATOR receiver
ER45_005690	COG0501	Belongs to the peptidase M48B family
ER45_005695	COG0697	spore germination
ER45_005720	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ER45_005735	COG1278	Cold shock
ER45_005745	COG4903	ComK protein
ER45_005750	COG0398	Pfam SNARE associated Golgi protein
ER45_005760	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ER45_005815	COG0179	Fumarylacetoacetate (FAA) hydrolase
ER45_005840	COG0367	asparagine synthase
ER45_005850	COG0753	catalase activity
ER45_005865	COG1666	GTP binding
ER45_005875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ER45_005885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_005900	COG0561	phosphatase activity
ER45_005920	COG2267	carboxylic ester hydrolase activity
ER45_005935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ER45_005940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ER45_005945	COG5504	Zn-dependent protease
ER45_005955	COG0180	Tryptophanyl-tRNA synthetase
ER45_005965	COG4166	transmembrane transport
ER45_005970	COG0601	transmembrane transport
ER45_005975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ER45_005980	COG0444	Belongs to the ABC transporter superfamily
ER45_005990	COG0534	Mate efflux family protein
ER45_005995	COG4166	transmembrane transport
ER45_006010	COG0861	Integral membrane protein TerC family
ER45_006015	COG4862	establishment of competence for transformation
ER45_006020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ER45_006030	COG1164	Oligoendopeptidase f
ER45_006045	COG2346	COG2346, Truncated hemoglobins
ER45_006050	COG4116	CYTH
ER45_006060	COG2357	RelA SpoT domain protein
ER45_006070	COG0564	pseudouridine synthase activity
ER45_006080	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ER45_006110	COG0463	Glycosyl transferase, family 2
ER45_006110	COG0457	Tetratricopeptide repeat
ER45_006130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ER45_006190	COG2153	protein acetylation
ER45_006195	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ER45_006200	COG2382	esterase
ER45_006225	COG5492	domain, Protein
ER45_006230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ER45_006240	COG0512	Glutamine amidotransferase of anthranilate synthase
ER45_006240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ER45_006245	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ER45_006250	COG0134	indole-3-glycerol-phosphate synthase activity
ER45_006255	COG0135	phosphoribosylanthranilate isomerase activity
ER45_006260	COG0133	tryptophan synthase activity
ER45_006265	COG0159	tryptophan synthase activity
ER45_006275	COG1620	l-lactate permease
ER45_006280	COG5634	Uncharacterized conserved protein (DUF2278)
ER45_006315	COG2226	methyltransferase
ER45_006335	COG0508	dehydrogenase complex catalyzes the overall conversion of
ER45_006345	COG1476	TRANSCRIPTIONal
ER45_006365	COG4152	abc transporter atp-binding protein
ER45_006370	COG1668	transmembrane transport
ER45_006390	COG1686	Belongs to the peptidase S11 family
ER45_006395	COG0681	Belongs to the peptidase S26 family
ER45_006430	COG1012	belongs to the aldehyde dehydrogenase family
ER45_006440	COG1176	ABC-type spermidine putrescine transport system, permease component I
ER45_006445	COG1177	transmembrane transport
ER45_006450	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
ER45_006460	COG2409	Drug exporters of the RND superfamily
ER45_006470	COG0564	pseudouridine synthase activity
ER45_006480	COG2340	Cysteine-rich secretory protein family
ER45_006485	COG0247	lactate metabolic process
ER45_006490	COG0277	FAD linked oxidase domain protein
ER45_006495	COG3835	regulator
ER45_006505	COG0745	RESPONSE REGULATOR receiver
ER45_006510	COG5002	protein histidine kinase activity
ER45_006515	COG2186	Transcriptional regulator
ER45_006520	COG0247	lactate metabolic process
ER45_006525	COG1139	Iron-sulfur cluster binding protein
ER45_006530	COG1556	Lactate utilization protein
ER45_006535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ER45_006545	COG2116	formate transmembrane transporter activity
ER45_006550	COG0861	Integral membrane protein TerC family
ER45_006565	COG2030	dehydratase
ER45_006585	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_006590	COG3243	poly(R)-hydroxyalkanoic acid synthase
ER45_006600	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ER45_006615	COG1840	ABC-type Fe3 transport system, periplasmic component
ER45_006620	COG3842	ATPase activity
ER45_006630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ER45_006635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ER45_006645	COG1349	DNA-binding transcription factor activity
ER45_006655	COG0235	Class ii aldolase
ER45_006665	COG2861	carbohydrate metabolic process
ER45_006675	COG3852	Histidine kinase
ER45_006680	COG1846	Transcriptional regulator
ER45_006690	COG2318	DinB family
ER45_006700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ER45_006705	COG0720	synthase
ER45_006715	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ER45_006720	COG4873	Protein conserved in bacteria
ER45_006735	COG0456	acetyltransferase
ER45_006750	COG1780	Probably involved in ribonucleotide reductase function
ER45_006765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ER45_006775	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ER45_006795	COG2204	response regulator
ER45_006800	COG1012	belongs to the aldehyde dehydrogenase family
ER45_006815	COG1131	(ABC) transporter
ER45_006825	COG1131	(ABC) transporter
ER45_006830	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ER45_006835	COG1266	CAAX protease self-immunity
ER45_006845	COG1522	sequence-specific DNA binding
ER45_006855	COG1335	isochorismatase
ER45_006865	COG1619	proteins homologs of microcin C7 resistance protein MccF
ER45_006870	COG2070	2-Nitropropane dioxygenase
ER45_006875	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ER45_006880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ER45_006910	COG0716	FMN binding
ER45_006945	COG0534	Mate efflux family protein
ER45_006970	COG1846	Transcriptional regulator
ER45_006980	COG1301	dicarboxylic acid transport
ER45_006985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ER45_006995	COG3874	Sporulation protein YtfJ
ER45_007020	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ER45_007025	COG0028	Belongs to the TPP enzyme family
ER45_007030	COG0440	acetolactate synthase activity
ER45_007040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ER45_007050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ER45_007060	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ER45_007065	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ER45_007075	COG0131	Imidazoleglycerol-phosphate dehydratase
ER45_007080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ER45_007090	COG0107	imidazoleglycerol-phosphate synthase activity
ER45_007100	COG0140	phosphoribosyl-ATP diphosphatase activity
ER45_007105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ER45_007120	COG1183	phosphatidylcholine synthase activity
ER45_007125	COG1368	sulfuric ester hydrolase activity
ER45_007135	COG0019	diaminopimelate decarboxylase activity
ER45_007145	COG0175	sulfate reduction
ER45_007150	COG2046	Belongs to the sulfate adenylyltransferase family
ER45_007155	COG0529	Catalyzes the synthesis of activated sulfate
ER45_007160	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ER45_007180	COG1648	precorrin-2 dehydrogenase activity
ER45_007185	COG0733	neurotransmitter:sodium symporter activity
ER45_007210	COG1757	Na H antiporter
ER45_007225	COG4758	membrane
ER45_007230	COG4585	Histidine kinase
ER45_007235	COG2197	response regulator
ER45_007245	COG1114	Component of the transport system for branched-chain amino acids
ER45_007255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ER45_007305	COG1392	Phosphate transport regulator
ER45_007310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ER45_007325	COG3852	Histidine kinase
ER45_007330	COG1801	Protein of unknown function DUF72
ER45_007340	COG0582	viral genome integration into host DNA
ER45_007345	COG5002	protein histidine kinase activity
ER45_007360	COG0392	lysyltransferase activity
ER45_007360	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ER45_007375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ER45_007380	COG1686	Belongs to the peptidase S11 family
ER45_007385	COG2715	membrane protein required for spore maturation
ER45_007390	COG0700	Nucleoside recognition
ER45_007395	COG1187	pseudouridine synthase activity
ER45_007405	COG1333	cytochrome c biogenesis protein
ER45_007410	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ER45_007415	COG0745	RESPONSE REGULATOR receiver
ER45_007420	COG5002	protein histidine kinase activity
ER45_007425	COG2096	Adenosyltransferase
ER45_007430	COG4942	peptidase
ER45_007440	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ER45_007445	COG1141	Ferredoxin
ER45_007450	COG4955	Helix-turn-helix domain
ER45_007455	COG0514	ATP-dependent DNA helicase (RecQ)
ER45_007460	COG1266	CAAX protease self-immunity
ER45_007485	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ER45_007505	COG0492	ferredoxin-NADP+ reductase activity
ER45_007530	COG1304	FMN binding
ER45_007565	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ER45_007585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ER45_007595	COG0302	gtp cyclohydrolase
ER45_007600	COG0142	geranyltranstransferase activity
ER45_007605	COG2226	methyltransferase
ER45_007610	COG0142	geranyltranstransferase activity
ER45_007635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ER45_007640	COG0457	Tetratricopeptide repeat
ER45_007645	COG5582	Belongs to the UPF0302 family
ER45_007660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ER45_007690	COG2738	Putative neutral zinc metallopeptidase
ER45_007700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_007705	COG1694	Mazg nucleotide pyrophosphohydrolase
ER45_007715	COG1803	Methylglyoxal synthase
ER45_007720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ER45_007725	COG0438	transferase activity, transferring glycosyl groups
ER45_007730	COG0617	tRNA 3'-terminal CCA addition
ER45_007740	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ER45_007745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ER45_007755	COG1199	ATP-dependent helicase activity
ER45_007755	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ER45_007775	COG3935	DnaD domain protein
ER45_007780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ER45_007790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ER45_007790	COG4499	WXG100 protein secretion system (Wss), protein YukC
ER45_007795	COG3331	DNA recombination
ER45_007835	COG4474	Belongs to the UPF0398 family
ER45_007840	COG3599	regulation of cell shape
ER45_007850	COG0116	Belongs to the methyltransferase superfamily
ER45_007855	COG4974	Belongs to the 'phage' integrase family
ER45_007960	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ER45_007970	COG0024	Methionine aminopeptidase
ER45_007980	COG2233	PERMEase
ER45_007985	COG2311	Membrane
ER45_007995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ER45_008005	COG0456	acetyltransferase
ER45_008015	COG2897	thiosulfate sulfurtransferase activity
ER45_008055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ER45_008070	COG0454	-acetyltransferase
ER45_008090	COG0328	RNA-DNA hybrid ribonuclease activity
ER45_008125	COG3403	YqcI/YcgG family
ER45_008130	COG1280	lysine exporter protein (LysE YggA)
ER45_008145	COG3162	membrane
ER45_008150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ER45_008155	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ER45_008170	COG0789	Transcriptional regulator
ER45_008170	COG4978	Transcriptional regulator
ER45_008180	COG2323	membrane
ER45_008185	COG1434	Gram-negative-bacterium-type cell wall biogenesis
ER45_008215	COG2814	Major facilitator Superfamily
ER45_008235	COG1923	regulation of RNA biosynthetic process
ER45_008245	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ER45_008250	COG1360	Flagellar Motor Protein
ER45_008255	COG2201	protein-glutamate methylesterase activity
ER45_008260	COG2198	Histidine kinase
ER45_008260	COG0643	Histidine kinase
ER45_008265	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ER45_008265	COG1776	CheC inhibitor of MCP methylation
ER45_008280	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ER45_008300	COG1256	bacterial-type flagellum assembly
ER45_008305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ER45_008325	COG1815	bacterial-type flagellum-dependent cell motility
ER45_008330	COG1558	bacterial-type flagellum-dependent cell motility
ER45_008340	COG1766	The M ring may be actively involved in energy transduction
ER45_008345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ER45_008375	COG1749	Flagellar hook protein flgE
ER45_008390	COG0835	chemotaxis
ER45_008390	COG0784	Response regulator, receiver
ER45_008410	COG0861	Integral membrane protein TerC family
ER45_008420	COG3383	formate dehydrogenase (NAD+) activity
ER45_008425	COG2427	Protein of unknown function (DUF1641)
ER45_008430	COG5609	conserved protein (DUF2294)
ER45_008435	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ER45_008445	COG2116	formate transmembrane transporter activity
ER45_008450	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ER45_008460	COG0314	molybdopterin synthase activity
ER45_008465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ER45_008475	COG0489	protein tyrosine kinase activity
ER45_008480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ER45_008485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ER45_008485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ER45_008505	COG1776	CheC inhibitor of MCP methylation
ER45_008505	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ER45_008515	COG1338	Plays a role in the flagellum-specific transport system
ER45_008520	COG1987	bacterial-type flagellum assembly
ER45_008530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ER45_008535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ER45_008540	COG1419	protein localization to endoplasmic reticulum
ER45_008545	COG4786	Flagellar basal body rod
ER45_008580	COG0412	Dienelactone hydrolase
ER45_008585	COG2329	Antibiotic biosynthesis monooxygenase
ER45_008600	COG2814	Major facilitator Superfamily
ER45_008610	COG0583	DNA-binding transcription factor activity
ER45_008615	COG3842	ATPase activity
ER45_008695	COG0367	asparagine synthase
ER45_008725	COG1802	Transcriptional regulator
ER45_008740	COG1216	Glycosyl transferase, family 2
ER45_008740	COG0438	transferase activity, transferring glycosyl groups
ER45_008745	COG1757	Na H antiporter
ER45_008755	COG0277	FAD linked oxidase domain protein
ER45_008775	COG0534	Mate efflux family protein
ER45_008780	COG3340	Belongs to the peptidase S51 family
ER45_008800	COG0785	Cytochrome C biogenesis protein
ER45_008805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ER45_008820	COG3048	D-serine ammonia-lyase activity
ER45_008825	COG2733	membrane
ER45_008860	COG1131	(ABC) transporter
ER45_008875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ER45_008880	COG0528	UMP kinase activity
ER45_008890	COG1027	Aspartate ammonia-lyase
ER45_008900	COG4191	Histidine kinase
ER45_008905	COG0784	Response regulator, receiver
ER45_008910	COG1846	Transcriptional regulator
ER45_008920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ER45_008930	COG2502	aspartate--ammonia ligase
ER45_008970	COG1051	belongs to the nudix hydrolase family
ER45_008975	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_008985	COG2814	Major facilitator Superfamily
ER45_009010	COG1695	Transcriptional regulator
ER45_009020	COG2814	Major facilitator Superfamily
ER45_009025	COG0640	Transcriptional regulator
ER45_009030	COG0477	Major facilitator Superfamily
ER45_009035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ER45_009050	COG2223	nitrite transmembrane transporter activity
ER45_009055	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ER45_009070	COG2244	polysaccharide biosynthetic process
ER45_009075	COG0733	neurotransmitter:sodium symporter activity
ER45_009085	COG5566	PFAM Mor transcription activator
ER45_009090	COG2323	membrane
ER45_009105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ER45_009115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ER45_009135	COG0129	dihydroxy-acid dehydratase activity
ER45_009140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ER45_009170	COG3384	dioxygenase
ER45_009195	COG4166	transmembrane transport
ER45_009200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ER45_009210	COG1914	H( )-stimulated, divalent metal cation uptake system
ER45_009215	COG1054	Belongs to the UPF0176 family
ER45_009225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ER45_009265	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ER45_009280	COG4257	antibiotic catabolic process
ER45_009285	COG2390	Transcriptional regulator
ER45_009295	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ER45_009300	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_009305	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ER45_009320	COG4846	Membrane protein involved in cytochrome C biogenesis
ER45_009335	COG0583	DNA-binding transcription factor activity
ER45_009355	COG0006	proline dipeptidase activity
ER45_009360	COG2132	Multicopper oxidase
ER45_009370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ER45_009380	COG0583	DNA-binding transcription factor activity
ER45_009400	COG1114	Component of the transport system for branched-chain amino acids
ER45_009410	COG2372	response to copper ion
ER45_009410	COG1276	copper resistance
ER45_009415	COG4549	nuclear export factor GLE1
ER45_009435	COG1959	2 iron, 2 sulfur cluster binding
ER45_009440	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ER45_009445	COG0778	Nitroreductase
ER45_009460	COG0628	permease
ER45_009475	COG1231	oxidoreductase activity
ER45_009480	COG0523	cobalamin synthesis protein
ER45_009495	COG2030	dehydratase
ER45_009500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ER45_009515	COG0411	ABC transporter
ER45_009535	COG0583	DNA-binding transcription factor activity
ER45_009545	COG1942	4-Oxalocrotonate Tautomerase
ER45_009560	COG0346	lactoylglutathione lyase activity
ER45_009570	COG1271	oxidase subunit
ER45_009575	COG1294	oxidase, subunit
ER45_009580	COG4988	ABC transporter
ER45_009615	COG1686	Belongs to the peptidase S11 family
ER45_009625	COG0791	NLP P60 protein
ER45_009625	COG1388	LysM domain
ER45_009635	COG1132	(ABC) transporter
ER45_009640	COG0745	RESPONSE REGULATOR receiver
ER45_009645	COG5002	protein histidine kinase activity
ER45_009650	COG0300	oxidoreductase activity
ER45_009655	COG4122	O-methyltransferase activity
ER45_009685	COG0460	homoserine dehydrogenase
ER45_009695	COG0083	homoserine kinase activity
ER45_009710	COG1316	TRANSCRIPTIONal
ER45_009730	COG1285	pathogenesis
ER45_009735	COG1247	-acetyltransferase
ER45_009755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ER45_009765	COG1082	Xylose isomerase domain protein TIM barrel
ER45_009775	COG2814	Major facilitator Superfamily
ER45_009785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ER45_009795	COG1752	Esterase of the alpha-beta hydrolase superfamily
ER45_009825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ER45_009835	COG2002	toxin-antitoxin pair type II binding
ER45_009840	COG1404	Belongs to the peptidase S8 family
ER45_009845	COG0640	Transcriptional regulator
ER45_009850	COG0667	Aldo Keto reductase
ER45_009895	COG3949	Membrane
ER45_009900	COG0783	Belongs to the Dps family
ER45_009925	COG1231	oxidoreductase activity
ER45_009930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ER45_009935	COG4989	oxidoreductase activity
ER45_009940	COG0523	cobalamin synthesis protein
ER45_009945	COG0456	acetyltransferase
ER45_009950	COG0803	Belongs to the bacterial solute-binding protein 9 family
ER45_009965	COG1902	pentaerythritol trinitrate reductase activity
ER45_009970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ER45_009980	COG4166	transmembrane transport
ER45_009985	COG0346	lactoylglutathione lyase activity
ER45_009995	COG0406	alpha-ribazole phosphatase activity
ER45_010005	COG5337	Spore coat protein CotH
ER45_010010	COG1051	belongs to the nudix hydrolase family
ER45_010015	COG0586	Pfam SNARE associated Golgi protein
ER45_010020	COG2244	polysaccharide biosynthetic process
ER45_010030	COG0701	Predicted permease
ER45_010035	COG3689	TIGRFAM TIGR03943 family protein
ER45_010040	COG1607	acyl-coa hydrolase
ER45_010050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ER45_010065	COG0702	epimerase
ER45_010075	COG1253	flavin adenine dinucleotide binding
ER45_010090	COG1114	Component of the transport system for branched-chain amino acids
ER45_010095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ER45_010110	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_010120	COG1876	peptidase activity
ER45_010135	COG2211	Major facilitator Superfamily
ER45_010150	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_010160	COG0561	phosphatase activity
ER45_010165	COG1846	Transcriptional regulator
ER45_010170	COG2814	Major facilitator Superfamily
ER45_010195	COG1819	glycosyl
ER45_010200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_010230	COG0456	acetyltransferase
ER45_010265	COG4499	WXG100 protein secretion system (Wss), protein YukC
ER45_010380	COG3874	Sporulation protein YtfJ
ER45_010405	COG2226	methyltransferase
ER45_010430	COG0346	lactoylglutathione lyase activity
ER45_010440	COG0604	alcohol dehydrogenase
ER45_010445	COG1595	DNA-templated transcription, initiation
ER45_010470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ER45_010470	COG0426	domain, Protein
ER45_010480	COG0386	Belongs to the glutathione peroxidase family
ER45_010485	COG1305	Transglutaminase-like
ER45_010490	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ER45_010495	COG0714	Associated with various cellular activities
ER45_010500	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
ER45_010530	COG2359	stage V sporulation protein S
ER45_010535	COG0582	viral genome integration into host DNA
ER45_010575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_010595	COG1418	mRNA catabolic process
ER45_010600	COG0488	(ABC) transporter
ER45_010620	COG1413	lyase activity
ER45_010635	COG2521	methyltransferase
ER45_010635	COG2136	Putative SAM-dependent methyltransferase
ER45_010640	COG0018	arginyl-trna synthetase
ER45_010690	COG0017	Asparaginyl-tRNA synthetase
ER45_010720	COG2610	gluconate transmembrane transporter activity
ER45_010730	COG1794	racemase activity, acting on amino acids and derivatives
ER45_010740	COG0456	acetyltransferase
ER45_010745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ER45_010755	COG1131	(ABC) transporter
ER45_010760	COG4473	ABC transporter
ER45_010770	COG0546	phosphoglycolate phosphatase activity
ER45_010800	COG0768	penicillin binding
ER45_010810	COG0204	Acyl-transferase
ER45_010815	COG1272	protein, Hemolysin III
ER45_010820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ER45_010825	COG0805	protein transport
ER45_010845	COG1999	signal sequence binding
ER45_010850	COG0071	Belongs to the small heat shock protein (HSP20) family
ER45_010855	COG0367	asparagine synthase
ER45_010870	COG0860	N-Acetylmuramoyl-L-alanine amidase
ER45_010875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_010880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ER45_010900	COG1335	isochorismatase
ER45_010910	COG0668	transmembrane transport
ER45_010920	COG2197	response regulator
ER45_010945	COG1070	Carbohydrate kinase
ER45_010955	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ER45_010975	COG0517	IMP dehydrogenase activity
ER45_010975	COG1125	glycine betaine transport
ER45_010980	COG1174	glycine betaine transport
ER45_011015	COG1253	flavin adenine dinucleotide binding
ER45_011020	COG1012	belongs to the aldehyde dehydrogenase family
ER45_011025	COG5506	Protein of unknown function (DUF1694)
ER45_011040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ER45_011045	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ER45_011050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ER45_011055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ER45_011060	COG0456	acetyltransferase
ER45_011065	COG3829	transcription factor binding
ER45_011070	COG1509	lysine 2,3-aminomutase activity
ER45_011080	COG4479	Belongs to the UPF0346 family
ER45_011105	COG3064	Membrane
ER45_011105	COG4991	sh3 domain protein
ER45_011105	COG0515	serine threonine protein kinase
ER45_011115	COG0671	phosphoesterase, PA-phosphatase related
ER45_011120	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ER45_011125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ER45_011180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ER45_011205	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_011225	COG4499	WXG100 protein secretion system (Wss), protein YukC
ER45_011225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ER45_011235	COG2814	Major facilitator Superfamily
ER45_011245	COG0372	Belongs to the citrate synthase family
ER45_011250	COG2079	MmgE PrpD family protein
ER45_011255	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ER45_011260	COG1960	acyl-CoA dehydrogenase activity
ER45_011265	COG2084	Dehydrogenase
ER45_011270	COG1012	belongs to the aldehyde dehydrogenase family
ER45_011275	COG1280	lysine exporter protein (LysE YggA)
ER45_011280	COG1024	Enoyl-CoA hydratase
ER45_011295	COG0420	3'-5' exonuclease activity
ER45_011320	COG2223	nitrite transmembrane transporter activity
ER45_011325	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_011330	COG1169	isochorismate synthase
ER45_011335	COG1021	2,3-dihydroxybenzoate-AMP ligase
ER45_011340	COG3433	isochorismatase activity
ER45_011340	COG1535	isochorismatase
ER45_011350	COG3251	PFAM MbtH domain protein
ER45_011355	COG2814	Major facilitator Superfamily
ER45_011370	COG0776	regulation of translation
ER45_011380	COG2318	DinB family
ER45_011385	COG1115	amino acid carrier protein
ER45_011400	COG2329	Antibiotic biosynthesis monooxygenase
ER45_011410	COG1187	pseudouridine synthase activity
ER45_011415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ER45_011420	COG3655	Transcriptional regulator
ER45_011430	COG1136	(ABC) transporter
ER45_011455	COG0028	Belongs to the TPP enzyme family
ER45_011465	COG2226	methyltransferase
ER45_011485	COG1253	flavin adenine dinucleotide binding
ER45_011525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ER45_011545	COG1846	Transcriptional regulator
ER45_011555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_011560	COG1309	transcriptional regulator
ER45_011590	COG1247	-acetyltransferase
ER45_011620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
ER45_011630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ER45_011660	COG0583	DNA-binding transcription factor activity
ER45_011665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ER45_011690	COG2258	MOSC domain
ER45_011710	COG1132	(ABC) transporter
ER45_011715	COG0582	viral genome integration into host DNA
ER45_011725	COG2308	Evidence 4 Homologs of previously reported genes of
ER45_011725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
ER45_011750	COG1396	sequence-specific DNA binding
ER45_011785	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
ER45_011790	COG1595	DNA-templated transcription, initiation
ER45_011865	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ER45_011865	COG2755	lipolytic protein G-D-S-L family
ER45_011875	COG2169	Transcriptional regulator
ER45_011885	COG0673	inositol 2-dehydrogenase activity
ER45_011925	COG1649	PFAM Uncharacterised BCR, COG1649
ER45_011945	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
ER45_011950	COG2971	BadF BadG BcrA BcrD
ER45_011960	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ER45_012000	COG1309	transcriptional regulator
ER45_012015	COG1136	(ABC) transporter
ER45_012020	COG0500	methyltransferase
ER45_012020	COG3615	Tellurite resistance protein tehB
ER45_012030	COG0693	protein deglycase activity
ER45_012040	COG0588	phosphoglycerate mutase activity
ER45_012065	COG2195	Cleaves the N-terminal amino acid of tripeptides
ER45_012075	COG0110	maltose O-acetyltransferase activity
ER45_012080	COG1136	(ABC) transporter
ER45_012100	COG5002	protein histidine kinase activity
ER45_012135	COG0745	RESPONSE REGULATOR receiver
ER45_012140	COG2205	protein histidine kinase activity
ER45_012145	COG1136	(ABC) transporter
ER45_012150	COG0577	efflux transmembrane transporter activity
ER45_012160	COG1595	DNA-templated transcription, initiation
ER45_012170	COG0768	penicillin binding
ER45_012175	COG0768	penicillin binding
ER45_012195	COG1252	NADH dehydrogenase
ER45_012200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ER45_012200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_012235	COG1136	(ABC) transporter
ER45_012240	COG0577	efflux transmembrane transporter activity
ER45_012275	COG2188	Transcriptional regulator
ER45_012290	COG0154	amidase activity
ER45_012300	COG2197	response regulator
ER45_012345	COG2031	fatty acid transporter
ER45_012365	COG3615	Tellurite resistance protein tehB
ER45_012365	COG0500	methyltransferase
ER45_012385	COG0463	Glycosyl transferase, family 2
ER45_012390	COG0463	Glycosyl transferase, family 2
ER45_012400	COG1086	Polysaccharide biosynthesis protein
ER45_012405	COG1088	dTDP-glucose 4,6-dehydratase activity
ER45_012410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ER45_012415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ER45_012430	COG2089	acid synthase
ER45_012435	COG4641	Protein conserved in bacteria
ER45_012480	COG0517	IMP dehydrogenase activity
ER45_012480	COG4175	Glycine betaine
ER45_012485	COG4176	ABC-type proline glycine betaine transport system permease component
ER45_012575	COG1131	(ABC) transporter
ER45_012580	COG1725	Transcriptional regulator
ER45_012590	COG3409	Peptidoglycan-binding domain 1 protein
ER45_012590	COG5632	N-Acetylmuramoyl-L-alanine amidase
ER45_012600	COG2239	Acts as a magnesium transporter
ER45_012605	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ER45_012620	COG0697	spore germination
ER45_012645	COG3397	chitin binding
ER45_012650	COG0823	Involved in the tonB-independent uptake of proteins
ER45_012660	COG1408	metallophosphoesterase
ER45_012680	COG1309	transcriptional regulator
ER45_012690	COG1960	acyl-CoA dehydrogenase activity
ER45_012700	COG0511	ligase activity, forming carbon-carbon bonds
ER45_012705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ER45_012710	COG1024	Enoyl-CoA hydratase
ER45_012715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ER45_012720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ER45_012795	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ER45_012845	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_012850	COG1733	regulation of RNA biosynthetic process
ER45_012910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ER45_012945	COG2323	membrane
ER45_012960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ER45_012985	COG0201	protein transport
ER45_013000	COG3227	Zinc metalloprotease (Elastase)
ER45_013020	COG0076	glutamate decarboxylase activity
ER45_013025	COG0657	acetylesterase activity
ER45_013030	COG1073	alpha beta
ER45_013040	COG0577	efflux transmembrane transporter activity
ER45_013045	COG1136	(ABC) transporter
ER45_013065	COG0745	RESPONSE REGULATOR receiver
ER45_013075	COG1011	Hydrolase
ER45_013105	COG1183	phosphatidylcholine synthase activity
ER45_013115	COG1132	(ABC) transporter
ER45_013120	COG3961	Belongs to the TPP enzyme family
ER45_013140	COG0322	excinuclease ABC activity
ER45_013165	COG2318	DinB family
ER45_013180	COG4667	esterase of the alpha-beta hydrolase superfamily
ER45_013205	COG3878	Protein conserved in bacteria
ER45_013230	COG1051	belongs to the nudix hydrolase family
ER45_013235	COG0592	DNA-directed DNA polymerase activity
ER45_013240	COG2816	NAD+ diphosphatase activity
ER45_013250	COG2223	nitrite transmembrane transporter activity
ER45_013260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ER45_013270	COG0494	nUDIX hydrolase
ER45_013290	COG0697	spore germination
ER45_013295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ER45_013310	COG0584	glycerophosphoryl diester phosphodiesterase
ER45_013325	COG2814	Major facilitator Superfamily
ER45_013365	COG0768	penicillin binding
ER45_013370	COG0671	phosphoesterase, PA-phosphatase related
ER45_013380	COG5002	protein histidine kinase activity
ER45_013385	COG0745	RESPONSE REGULATOR receiver
ER45_013405	COG2205	protein histidine kinase activity
ER45_013425	COG4720	Psort location CytoplasmicMembrane, score
ER45_013430	COG1794	racemase activity, acting on amino acids and derivatives
ER45_013435	COG1819	glycosyl
ER45_013450	COG5002	protein histidine kinase activity
ER45_013455	COG0561	phosphatase activity
ER45_013500	COG2124	cytochrome p450
ER45_013635	COG0740	serine-type endopeptidase activity
ER45_013645	COG1802	Transcriptional regulator
ER45_013645	COG4626	Terminase
ER45_013675	COG0582	viral genome integration into host DNA
ER45_013740	COG2002	toxin-antitoxin pair type II binding
ER45_013750	COG1484	DNA-dependent DNA replication
ER45_013775	COG1396	sequence-specific DNA binding
ER45_013790	COG0582	viral genome integration into host DNA
ER45_013800	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ER45_013810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ER45_013815	COG0460	homoserine dehydrogenase
ER45_013835	COG0577	efflux transmembrane transporter activity
ER45_013840	COG1136	(ABC) transporter
ER45_013850	COG0488	(ABC) transporter
ER45_013855	COG0667	Aldo Keto reductase
ER45_013860	COG0583	DNA-binding transcription factor activity
ER45_013865	COG2205	protein histidine kinase activity
ER45_013870	COG0745	RESPONSE REGULATOR receiver
ER45_013880	COG3773	Cell wall hydrolase
ER45_013890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ER45_013900	COG3386	PFAM SMP-30 Gluconolaconase
ER45_013940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ER45_013955	COG2959	enzyme of heme biosynthesis
ER45_013980	COG3483	tryptophan 2,3-dioxygenase activity
ER45_013985	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
ER45_013990	COG3844	kynureninase activity
ER45_013995	COG1309	transcriptional regulator
ER45_014010	COG3284	Transcriptional regulator
ER45_014025	COG1349	DNA-binding transcription factor activity
ER45_014045	COG1959	2 iron, 2 sulfur cluster binding
ER45_014060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ER45_014065	COG0508	dehydrogenase complex catalyzes the overall conversion of
ER45_014070	COG0022	dehydrogenase e1 component
ER45_014075	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ER45_014085	COG2223	nitrite transmembrane transporter activity
ER45_014095	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_014135	COG4176	ABC-type proline glycine betaine transport system permease component
ER45_014140	COG0517	IMP dehydrogenase activity
ER45_014140	COG4175	Glycine betaine
ER45_014165	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ER45_014170	COG2153	protein acetylation
ER45_014175	COG3397	chitin binding
ER45_014185	COG1819	glycosyl
ER45_014200	COG2205	protein histidine kinase activity
ER45_014205	COG2315	Protein conserved in bacteria
ER45_014255	COG3973	AAA domain
ER45_014265	COG2105	PFAM AIG2 family protein
ER45_014295	COG4637	Psort location Cytoplasmic, score
ER45_014305	COG1227	inorganic diphosphatase activity
ER45_014310	COG3397	chitin binding
ER45_014315	COG2318	DinB family
ER45_014335	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ER45_014340	COG1115	amino acid carrier protein
ER45_014345	COG1012	belongs to the aldehyde dehydrogenase family
ER45_014350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ER45_014365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ER45_014405	COG0586	Pfam SNARE associated Golgi protein
ER45_014420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ER45_014425	COG4166	transmembrane transport
ER45_014435	COG4948	Mandelate Racemase Muconate Lactonizing
ER45_014455	COG0667	Aldo Keto reductase
ER45_014520	COG0745	RESPONSE REGULATOR receiver
ER45_014540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ER45_014545	COG1164	Oligoendopeptidase f
ER45_014560	COG1307	EDD domain protein, DegV family
ER45_014585	COG1335	isochorismatase
ER45_014600	COG2814	Major facilitator Superfamily
ER45_014610	COG1664	Polymer-forming cytoskeletal
ER45_014615	COG0789	Transcriptional regulator
ER45_014620	COG4533	DNA binding
ER45_014625	COG0477	Major facilitator Superfamily
ER45_014625	COG2814	Major facilitator Superfamily
ER45_014645	COG2261	transglycosylase associated protein
ER45_014660	COG2226	methyltransferase
ER45_014695	COG0436	Aminotransferase
ER45_014700	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ER45_014725	COG1131	(ABC) transporter
ER45_014730	COG2188	Transcriptional regulator
ER45_014775	COG0628	permease
ER45_014820	COG2746	aminoglycoside 3-N-acetyltransferase activity
ER45_014830	COG0697	spore germination
ER45_014835	COG2318	DinB family
ER45_014885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ER45_014895	COG2814	Major facilitator Superfamily
ER45_014900	COG1368	sulfuric ester hydrolase activity
ER45_014915	COG0488	(ABC) transporter
ER45_014920	COG1033	growth of symbiont in host cell
ER45_014920	COG2409	Drug exporters of the RND superfamily
ER45_014925	COG1309	transcriptional regulator
ER45_014960	COG1605	Chorismate mutase
ER45_014960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ER45_015005	COG3584	3D domain protein
ER45_015005	COG1388	LysM domain
ER45_015015	COG0346	lactoylglutathione lyase activity
ER45_015025	COG0431	NADPH-dependent FMN reductase
ER45_015055	COG0579	oxidoreductase
ER45_015060	COG1879	ABC-type sugar transport system periplasmic component
ER45_015075	COG1129	ABC transporter
ER45_015080	COG2390	Transcriptional regulator
ER45_015100	COG2226	methyltransferase
ER45_015120	COG2329	Antibiotic biosynthesis monooxygenase
ER45_015150	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_015155	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ER45_015160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ER45_015165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ER45_015170	COG3239	Fatty acid desaturase
ER45_015195	COG3842	ATPase activity
ER45_015220	COG1175	transmembrane transport
ER45_015225	COG1349	DNA-binding transcription factor activity
ER45_015235	COG3655	Transcriptional regulator
ER45_015250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ER45_015255	COG0346	lactoylglutathione lyase activity
ER45_015285	COG0714	Associated with various cellular activities
ER45_015310	COG0753	catalase activity
ER45_015320	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ER45_015345	COG0714	Associated with various cellular activities
ER45_015355	COG0778	Nitroreductase
ER45_015360	COG1846	Transcriptional regulator
ER45_015375	COG0494	nUDIX hydrolase
ER45_015395	COG1725	Transcriptional regulator
ER45_015425	COG2207	Transcriptional regulator
ER45_015430	COG0456	acetyltransferase
ER45_015445	COG0697	spore germination
ER45_015480	COG0697	spore germination
ER45_015495	COG0642	Histidine kinase
ER45_015500	COG0745	RESPONSE REGULATOR receiver
ER45_015505	COG0596	Alpha beta hydrolase
ER45_015515	COG0456	acetyltransferase
ER45_015515	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ER45_015540	COG0730	response to heat
ER45_015550	COG0833	amino acid
ER45_015560	COG4335	DNA alkylation repair
ER45_015590	COG0768	penicillin binding
ER45_015605	COG3104	oligopeptide transport
ER45_015610	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ER45_015625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ER45_015630	COG1984	allophanate hydrolase subunit 2
ER45_015635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ER45_015640	COG1414	Transcriptional regulator
ER45_015655	COG1960	acyl-CoA dehydrogenase activity
ER45_015680	COG0640	Transcriptional regulator
ER45_015710	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ER45_015715	COG0577	efflux transmembrane transporter activity
ER45_015720	COG0577	efflux transmembrane transporter activity
ER45_015725	COG1136	(ABC) transporter
ER45_015760	COG3848	Pyruvate phosphate dikinase
ER45_015760	COG0574	Belongs to the PEP-utilizing enzyme family
ER45_015770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ER45_015795	COG5002	protein histidine kinase activity
ER45_015800	COG0745	RESPONSE REGULATOR receiver
ER45_015810	COG1575	Belongs to the MenA family. Type 1 subfamily
ER45_015840	COG0798	PFAM Bile acid sodium symporter
ER45_015845	COG0346	lactoylglutathione lyase activity
ER45_015850	COG0640	Transcriptional regulator
ER45_015890	COG1522	sequence-specific DNA binding
ER45_015910	COG0346	lactoylglutathione lyase activity
ER45_015940	COG5002	protein histidine kinase activity
ER45_015940	COG3850	Histidine kinase
ER45_015970	COG1073	alpha beta
ER45_015975	COG0814	amino acid
ER45_015980	COG1760	l-serine dehydratase
ER45_015985	COG1760	l-serine dehydratase
ER45_015995	COG5002	protein histidine kinase activity
ER45_016000	COG0745	RESPONSE REGULATOR receiver
ER45_016035	COG4977	sequence-specific DNA binding
ER45_016065	COG2197	response regulator
ER45_016090	COG2515	1-aminocyclopropane-1-carboxylate deaminase
ER45_016115	COG1522	sequence-specific DNA binding
ER45_016125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ER45_016140	COG1136	(ABC) transporter
ER45_016165	COG5002	protein histidine kinase activity
ER45_016165	COG3850	Histidine kinase
ER45_016175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_016315	COG0740	serine-type endopeptidase activity
ER45_016365	COG0582	viral genome integration into host DNA
ER45_016405	COG0463	Glycosyl transferase, family 2
ER45_016455	COG2002	toxin-antitoxin pair type II binding
ER45_016505	COG1619	proteins homologs of microcin C7 resistance protein MccF
ER45_016560	COG2814	Major facilitator Superfamily
ER45_016630	COG2849	repeat protein
ER45_016635	COG5444	nuclease activity
ER45_016645	COG5444	nuclease activity
ER45_016685	COG0477	Major facilitator Superfamily
ER45_016700	COG1846	Transcriptional regulator
ER45_016705	COG2814	Major facilitator Superfamily
ER45_016725	COG0640	Transcriptional regulator
ER45_016805	COG5002	protein histidine kinase activity
ER45_016835	COG1131	(ABC) transporter
ER45_016945	COG4187	Peptidase family M20/M25/M40
ER45_016950	COG1414	Transcriptional regulator
ER45_016955	COG0833	amino acid
ER45_016975	COG2249	NAD(P)H dehydrogenase (quinone) activity
ER45_017025	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ER45_017030	COG1288	antiporter activity
ER45_017035	COG2356	endonuclease I
ER45_017040	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ER45_017060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ER45_017080	COG1785	Belongs to the alkaline phosphatase family
ER45_017085	COG0778	Nitroreductase
ER45_017090	COG1733	regulation of RNA biosynthetic process
ER45_017105	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_017115	COG1131	(ABC) transporter
ER45_017145	COG1011	Hydrolase
ER45_017150	COG2365	Tyrosine phosphatase family
ER45_017175	COG0346	lactoylglutathione lyase activity
ER45_017180	COG1940	carbohydrate kinase activity
ER45_017185	COG0738	Major facilitator superfamily
ER45_017190	COG0110	maltose O-acetyltransferase activity
ER45_017205	COG0628	permease
ER45_017210	COG2261	transglycosylase associated protein
ER45_017225	COG1720	tRNA m6t6A37 methyltransferase activity
ER45_017230	COG0500	methyltransferase
ER45_017240	COG0477	Major facilitator Superfamily
ER45_017255	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ER45_017265	COG1253	flavin adenine dinucleotide binding
ER45_017270	COG0789	Transcriptional regulator
ER45_017280	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ER45_017305	COG0697	spore germination
ER45_017310	COG1357	PFAM Pentapeptide repeats (8 copies)
ER45_017315	COG3813	Protein conserved in bacteria
ER45_017320	COG2706	6-phosphogluconolactonase activity
ER45_017325	COG1070	Carbohydrate kinase
ER45_017335	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ER45_017340	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ER45_017375	COG1393	Belongs to the ArsC family
ER45_017385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_017400	COG0494	nUDIX hydrolase
ER45_017425	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_017430	COG2249	NAD(P)H dehydrogenase (quinone) activity
ER45_017435	COG1733	regulation of RNA biosynthetic process
ER45_017450	COG1191	sigma factor activity
ER45_017465	COG1876	peptidase activity
ER45_017495	COG0741	lytic transglycosylase activity
ER45_017515	COG2197	response regulator
ER45_017520	COG4585	Histidine kinase
ER45_017605	COG0814	amino acid
ER45_017630	COG1151	hydroxylamine reductase activity
ER45_017660	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ER45_017670	COG2072	flavoprotein involved in K transport
ER45_017715	COG1695	Transcriptional regulator
ER45_017720	COG0604	alcohol dehydrogenase
ER45_017725	COG1113	amino acid transport
ER45_017735	COG2814	Major facilitator Superfamily
ER45_017745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ER45_017750	COG1012	belongs to the aldehyde dehydrogenase family
ER45_017760	COG0534	Mate efflux family protein
ER45_017765	COG1012	belongs to the aldehyde dehydrogenase family
ER45_017770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ER45_017785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ER45_017810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_017815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_017825	COG3739	integral membrane protein
ER45_017890	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ER45_017900	COG2957	Belongs to the agmatine deiminase family
ER45_017920	COG3781	membrane
ER45_017935	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ER45_017970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ER45_017975	COG0640	Transcriptional regulator
ER45_017980	COG0604	alcohol dehydrogenase
ER45_017985	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
ER45_017995	COG0457	Tetratricopeptide repeat
ER45_018000	COG2808	Putative FMN-binding domain
ER45_018015	COG0277	FAD linked oxidase domain protein
ER45_018035	COG1285	pathogenesis
ER45_018045	COG2514	catechol 2,3-dioxygenase activity
ER45_018055	COG1126	abc transporter atp-binding protein
ER45_018060	COG0765	amino acid transport
ER45_018065	COG2720	vancomycin resistance protein
ER45_018090	COG1278	Cold shock
ER45_018100	COG0716	FMN binding
ER45_018110	COG0494	nUDIX hydrolase
ER45_018130	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_018140	COG0165	Argininosuccinate lyase
ER45_018155	COG4145	pantothenate transmembrane transporter activity
ER45_018165	COG1012	belongs to the aldehyde dehydrogenase family
ER45_018170	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_018180	COG1657	PFAM Prenyltransferase squalene oxidase
ER45_018185	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ER45_018190	COG2962	Rard protein
ER45_018195	COG3326	Membrane
ER45_018200	COG0531	amino acid
ER45_018235	COG2226	methyltransferase
ER45_018250	COG4166	transmembrane transport
ER45_018255	COG1316	TRANSCRIPTIONal
ER45_018275	COG1131	(ABC) transporter
ER45_018295	COG0673	inositol 2-dehydrogenase activity
ER45_018300	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ER45_018310	COG1832	CoA-binding protein
ER45_018315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ER45_018320	COG0745	RESPONSE REGULATOR receiver
ER45_018330	COG1328	CTP reductase activity
ER45_018340	COG4841	protein insertion into membrane
ER45_018345	COG0824	Thioesterase
ER45_018370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ER45_018385	COG1132	(ABC) transporter
ER45_018390	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ER45_018420	COG2211	Major facilitator Superfamily
ER45_018430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ER45_018445	COG0183	Belongs to the thiolase family
ER45_018450	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_018455	COG1268	BioY protein
ER45_018460	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_018465	COG1396	sequence-specific DNA binding
ER45_018485	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
ER45_018505	COG0830	nickel cation binding
ER45_018545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_018565	COG0400	carboxylic ester hydrolase activity
ER45_018570	COG0346	lactoylglutathione lyase activity
ER45_018575	COG0069	glutamate synthase activity
ER45_018580	COG1902	pentaerythritol trinitrate reductase activity
ER45_018590	COG1329	Transcriptional regulator
ER45_018595	COG0010	Belongs to the arginase family
ER45_018605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ER45_018610	COG2986	histidine ammonia-lyase
ER45_018620	COG2226	methyltransferase
ER45_018645	COG4846	Membrane protein involved in cytochrome C biogenesis
ER45_018650	COG0785	Cytochrome C biogenesis protein
ER45_018660	COG1473	amidohydrolase
ER45_018665	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ER45_018670	COG1131	(ABC) transporter
ER45_018680	COG0583	DNA-binding transcription factor activity
ER45_018690	COG1346	cytolysis
ER45_018705	COG0730	response to heat
ER45_018715	COG3409	Peptidoglycan-binding domain 1 protein
ER45_018715	COG5632	N-Acetylmuramoyl-L-alanine amidase
ER45_018740	COG1132	(ABC) transporter
ER45_018745	COG3763	UPF0154 protein
ER45_018780	COG0737	Belongs to the 5'-nucleotidase family
ER45_018795	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ER45_018810	COG1695	Transcriptional regulator
ER45_018815	COG1132	(ABC) transporter
ER45_018850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ER45_018860	COG1181	Belongs to the D-alanine--D-alanine ligase family
ER45_018865	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ER45_018870	COG3420	alginic acid biosynthetic process
ER45_018870	COG5434	Belongs to the glycosyl hydrolase 28 family
ER45_018895	COG0438	transferase activity, transferring glycosyl groups
ER45_018905	COG0463	Glycosyl transferase, family 2
ER45_018905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ER45_018910	COG0438	transferase activity, transferring glycosyl groups
ER45_018915	COG0438	transferase activity, transferring glycosyl groups
ER45_018920	COG1086	Polysaccharide biosynthesis protein
ER45_018925	COG0489	protein tyrosine kinase activity
ER45_018930	COG3944	biosynthesis protein
ER45_018935	COG0174	glutamine synthetase
ER45_018940	COG0789	Transcriptional regulator
ER45_018945	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ER45_018950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ER45_018955	COG2860	membrane
ER45_018965	COG0464	growth
ER45_018985	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ER45_018995	COG3584	3D domain protein
ER45_018995	COG1388	LysM domain
ER45_019000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ER45_019000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ER45_019000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ER45_019005	COG1105	Belongs to the carbohydrate kinase PfkB family
ER45_019010	COG1349	DNA-binding transcription factor activity
ER45_019015	COG1979	alcohol dehydrogenase
ER45_019020	COG2322	membrane
ER45_019045	COG1408	metallophosphoesterase
ER45_019050	COG2116	formate transmembrane transporter activity
ER45_019065	COG2217	Heavy metal translocating P-type atpase
ER45_019070	COG2608	mercury ion transmembrane transporter activity
ER45_019075	COG1937	Protein conserved in bacteria
ER45_019105	COG4566	intracellular signal transduction
ER45_019110	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ER45_019115	COG2819	hydrolase of the alpha beta superfamily
ER45_019120	COG1120	ATPase activity
ER45_019125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_019130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_019135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_019140	COG0708	Exodeoxyribonuclease III
ER45_019145	COG2169	Transcriptional regulator
ER45_019150	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ER45_019160	COG2706	6-phosphogluconolactonase activity
ER45_019165	COG2195	Cleaves the N-terminal amino acid of tripeptides
ER45_019180	COG0346	lactoylglutathione lyase activity
ER45_019225	COG1346	cytolysis
ER45_019240	COG0508	dehydrogenase complex catalyzes the overall conversion of
ER45_019240	COG0596	Alpha beta hydrolase
ER45_019245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ER45_019255	COG2188	Transcriptional regulator
ER45_019260	COG2723	6-phospho-beta-galactosidase activity
ER45_019265	COG0823	Involved in the tonB-independent uptake of proteins
ER45_019270	COG3773	Cell wall hydrolase
ER45_019280	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ER45_019290	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ER45_019295	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ER45_019300	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ER45_019310	COG4550	Control of competence regulator ComK, YlbF/YmcA
ER45_019315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ER45_019320	COG1013	pyruvate-flavodoxin oxidoreductase activity
ER45_019325	COG0674	pyruvate-flavodoxin oxidoreductase activity
ER45_019325	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ER45_019335	COG2359	stage V sporulation protein S
ER45_019340	COG1692	metallophosphoesterase
ER45_019345	COG1418	mRNA catabolic process
ER45_019350	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ER45_019360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ER45_019365	COG1426	Protein conserved in bacteria
ER45_019385	COG0612	Peptidase, M16
ER45_019390	COG0612	Peptidase, M16
ER45_019395	COG1079	Belongs to the binding-protein-dependent transport system permease family
ER45_019400	COG4603	Belongs to the binding-protein-dependent transport system permease family
ER45_019405	COG3845	ABC transporter
ER45_019410	COG1744	ABC transporter substrate-binding protein PnrA-like
ER45_019415	COG2188	Transcriptional regulator
ER45_019420	COG1674	ftsk spoiiie
ER45_019430	COG0740	serine-type endopeptidase activity
ER45_019435	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ER45_019445	COG0527	aspartate kinase activity
ER45_019450	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ER45_019460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ER45_019465	COG1873	PFAM PRC-barrel domain
ER45_019470	COG0612	Peptidase, M16
ER45_019480	COG1185	polyribonucleotide nucleotidyltransferase activity
ER45_019490	COG0196	riboflavin kinase activity
ER45_019500	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ER45_019505	COG1550	Protein conserved in bacteria
ER45_019510	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ER45_019515	COG1358	cellular component organization or biogenesis
ER45_019520	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ER45_019530	COG0779	Required for maturation of 30S ribosomal subunits
ER45_019540	COG0442	prolyl-tRNA aminoacylation
ER45_019555	COG4589	Belongs to the CDS family
ER45_019565	COG0233	cytoplasmic translational termination
ER45_019570	COG0528	UMP kinase activity
ER45_019575	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ER45_019585	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ER45_019590	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ER45_019595	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ER45_019600	COG4974	Belongs to the 'phage' integrase family
ER45_019605	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ER45_019610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ER45_019615	COG0758	DNA mediated transformation
ER45_019620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ER45_019625	COG0045	succinate-CoA ligase (ADP-forming) activity
ER45_019630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ER45_019645	COG0335	large ribosomal subunit rRNA binding
ER45_019650	COG0336	Belongs to the RNA methyltransferase TrmD family
ER45_019655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ER45_019660	COG1837	Belongs to the UPF0109 family
ER45_019680	COG0552	protein localization to endoplasmic reticulum
ER45_019685	COG1196	nuclear chromosome segregation
ER45_019695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ER45_019700	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_019710	COG0416	fatty acid biosynthetic process
ER45_019715	COG2050	protein possibly involved in aromatic compounds catabolism
ER45_019715	COG1349	DNA-binding transcription factor activity
ER45_019720	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ER45_019730	COG1302	Protein conserved in bacteria
ER45_019745	COG1564	THIamine pyrophosphokinase
ER45_019750	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ER45_019760	COG2815	serine threonine protein kinase
ER45_019760	COG0515	serine threonine protein kinase
ER45_019765	COG0631	protein serine/threonine phosphatase activity
ER45_019770	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ER45_019775	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ER45_019775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ER45_019780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ER45_019785	COG0242	peptide deformylase activity
ER45_019790	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ER45_019795	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ER45_019800	COG1758	RNA polymerase activity
ER45_019815	COG1561	YicC-like family, N-terminal region
ER45_019830	COG0006	proline dipeptidase activity
ER45_019850	COG3069	C4-dicarboxylate transmembrane transporter activity
ER45_019875	COG0167	dihydroorotate dehydrogenase activity
ER45_019880	COG0543	2 iron, 2 sulfur cluster binding
ER45_019885	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ER45_019895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ER45_019910	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ER45_019915	COG0564	pseudouridine synthase activity
ER45_019920	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ER45_019930	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ER45_019935	COG3599	regulation of cell shape
ER45_019940	COG2302	S4 RNA-binding domain
ER45_019945	COG0762	integral membrane protein
ER45_019950	COG1799	cell septum assembly
ER45_019955	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ER45_019965	COG1873	PFAM PRC-barrel domain
ER45_019970	COG1191	sigma factor activity
ER45_019975	COG1191	sigma factor activity
ER45_019985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ER45_019990	COG0849	cell division
ER45_020010	COG0772	Belongs to the SEDS family
ER45_020015	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ER45_020020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ER45_020025	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ER45_020030	COG0768	penicillin binding
ER45_020035	COG0768	penicillin binding
ER45_020045	COG0275	rRNA processing
ER45_020055	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ER45_020060	COG0454	-acetyltransferase
ER45_020070	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ER45_020075	COG1399	metal-binding, possibly nucleic acid-binding protein
ER45_020080	COG1323	Belongs to the UPF0348 family
ER45_020085	COG3480	Lon protease (S16) C-terminal proteolytic domain
ER45_020090	COG1752	Esterase of the alpha-beta hydrolase superfamily
ER45_020095	COG3314	Sporulation integral membrane protein YlbJ
ER45_020105	COG0742	ribosomal rna small subunit methyltransferase
ER45_020115	COG4471	UPF0298 protein
ER45_020120	COG3679	Belongs to the UPF0342 family
ER45_020125	COG0406	alpha-ribazole phosphatase activity
ER45_020140	COG2340	Cysteine-rich secretory protein family
ER45_020150	COG3336	cytochrome c oxidase
ER45_020180	COG1612	heme a metabolic process
ER45_020185	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ER45_020190	COG0772	Belongs to the SEDS family
ER45_020195	COG4838	Belongs to the UPF0358 family
ER45_020200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ER45_020205	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ER45_020215	COG4896	Protein conserved in bacteria
ER45_020240	COG0483	inositol monophosphate 1-phosphatase activity
ER45_020250	COG4493	Belongs to the UPF0637 family
ER45_020255	COG4476	Belongs to the UPF0223 family
ER45_020260	COG1982	Orn Lys Arg decarboxylase major
ER45_020305	COG0508	dehydrogenase complex catalyzes the overall conversion of
ER45_020310	COG0022	dehydrogenase e1 component
ER45_020315	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ER45_020335	COG5503	Protein of unknown function (DUF1447)
ER45_020340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ER45_020345	COG0569	domain protein
ER45_020355	COG1473	amidohydrolase
ER45_020360	COG2171	N-acyltransferase activity
ER45_020365	COG0583	DNA-binding transcription factor activity
ER45_020370	COG0517	IMP dehydrogenase activity
ER45_020380	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ER45_020390	COG4703	Protein of unknown function (DUF1797)
ER45_020405	COG2200	EAL domain
ER45_020410	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_020415	COG1408	metallophosphoesterase
ER45_020460	COG2814	Major facilitator Superfamily
ER45_020470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ER45_020480	COG3209	COG3209 Rhs family protein
ER45_020490	COG2205	protein histidine kinase activity
ER45_020500	COG0436	Aminotransferase
ER45_020505	COG1609	Transcriptional regulator
ER45_020510	COG3833	ABC-type maltose transport systems, permease component
ER45_020515	COG1175	transmembrane transport
ER45_020520	COG2182	Extracellular solute-binding protein
ER45_020535	COG3842	ATPase activity
ER45_020610	COG1695	Transcriptional regulator
ER45_020615	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_020625	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ER45_020630	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ER45_020635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ER45_020640	COG0436	Aminotransferase
ER45_020645	COG1850	ribulose-bisphosphate carboxylase activity
ER45_020650	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ER45_020660	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ER45_020675	COG2084	Dehydrogenase
ER45_020685	COG2199	diguanylate cyclase activity
ER45_020690	COG0778	Nitroreductase
ER45_020715	COG1263	PTS System
ER45_020715	COG2190	(PTS) system
ER45_020715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ER45_020720	COG3711	transcriptional antiterminator
ER45_020730	COG2188	Transcriptional regulator
ER45_020735	COG0363	glucosamine-6-phosphate deaminase activity
ER45_020740	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ER45_020750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ER45_020755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ER45_020765	COG1547	Domain of unknown function (DUF309)
ER45_020775	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ER45_020780	COG4086	secreted protein
ER45_020785	COG0561	phosphatase activity
ER45_020790	COG0697	spore germination
ER45_020830	COG0733	neurotransmitter:sodium symporter activity
ER45_020850	COG1686	Belongs to the peptidase S11 family
ER45_020855	COG1725	Transcriptional regulator
ER45_020860	COG1131	(ABC) transporter
ER45_020885	COG1846	Transcriptional regulator
ER45_020915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ER45_020925	COG4974	Belongs to the 'phage' integrase family
ER45_020935	COG0735	belongs to the Fur family
ER45_020940	COG1300	Membrane
ER45_020960	COG0667	Aldo Keto reductase
ER45_020965	COG0656	L-ascorbic acid biosynthetic process
ER45_020970	COG0456	acetyltransferase
ER45_020970	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ER45_020985	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ER45_021000	COG2056	Na+-H+ antiporter family
ER45_021005	COG1609	Transcriptional regulator
ER45_021010	COG0456	acetyltransferase
ER45_021015	COG1073	alpha beta
ER45_021030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ER45_021030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ER45_021035	COG0307	riboflavin synthase, alpha
ER45_021040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ER45_021040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ER45_021055	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ER45_021060	COG4106	trans-aconitate 2-methyltransferase activity
ER45_021065	COG1073	alpha beta
ER45_021065	COG2226	methyltransferase
ER45_021070	COG0156	8-amino-7-oxononanoate synthase activity
ER45_021080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ER45_021090	COG1757	Na H antiporter
ER45_021095	COG0737	Belongs to the 5'-nucleotidase family
ER45_021105	COG1522	sequence-specific DNA binding
ER45_021140	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ER45_021150	COG0300	oxidoreductase activity
ER45_021155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_021160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ER45_021165	COG1760	l-serine dehydratase
ER45_021170	COG1760	l-serine dehydratase
ER45_021180	COG1234	tRNA 3'-trailer cleavage
ER45_021195	COG1285	pathogenesis
ER45_021210	COG2195	Cleaves the N-terminal amino acid of tripeptides
ER45_021215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ER45_021230	COG1376	ErfK ybiS ycfS ynhG family protein
ER45_021235	COG4129	membrane
ER45_021240	COG1126	abc transporter atp-binding protein
ER45_021245	COG0765	amino acid transport
ER45_021250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ER45_021265	COG2816	NAD+ diphosphatase activity
ER45_021270	COG2323	membrane
ER45_021275	COG0772	Belongs to the SEDS family
ER45_021285	COG0022	dehydrogenase e1 component
ER45_021295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ER45_021300	COG3426	butyrate kinase activity
ER45_021310	COG0280	phosphate acetyltransferase
ER45_021315	COG3829	transcription factor binding
ER45_021315	COG3290	protein histidine kinase activity
ER45_021325	COG0584	glycerophosphoryl diester phosphodiesterase
ER45_021330	COG3093	addiction module antidote protein HigA
ER45_021370	COG0745	RESPONSE REGULATOR receiver
ER45_021375	COG0750	zinc metalloprotease
ER45_021380	COG0497	DNA recombination
ER45_021385	COG1438	arginine binding
ER45_021390	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ER45_021395	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ER45_021400	COG0142	geranyltranstransferase activity
ER45_021405	COG1722	exodeoxyribonuclease VII activity
ER45_021415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ER45_021420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ER45_021425	COG1302	Protein conserved in bacteria
ER45_021430	COG0439	Biotin carboxylase
ER45_021435	COG0511	ligase activity, forming carbon-carbon bonds
ER45_021480	COG3854	ATPases associated with a variety of cellular activities
ER45_021500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ER45_021505	COG0006	proline dipeptidase activity
ER45_021510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ER45_021520	COG3872	metal-dependent enzyme
ER45_021530	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ER45_021565	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ER45_021575	COG1609	Transcriptional regulator
ER45_021585	COG2076	Multidrug Resistance protein
ER45_021590	COG2076	Multidrug Resistance protein
ER45_021630	COG1725	Transcriptional regulator
ER45_021645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ER45_021650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ER45_021655	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ER45_021660	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ER45_021685	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ER45_021710	COG4970	Tfp pilus assembly protein FimT
ER45_021725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ER45_021785	COG0646	methionine synthase
ER45_021785	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ER45_021790	COG0626	cystathionine gamma-synthase activity
ER45_021795	COG0626	cystathionine gamma-synthase activity
ER45_021810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_021820	COG1940	carbohydrate kinase activity
ER45_021825	COG4483	Protein conserved in bacteria
ER45_021830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ER45_021835	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ER45_021840	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ER45_021845	COG0704	Plays a role in the regulation of phosphate uptake
ER45_021855	COG0581	inorganic phosphate transmembrane transporter activity
ER45_021860	COG0573	inorganic phosphate transmembrane transporter activity
ER45_021865	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ER45_021870	COG0768	penicillin binding
ER45_021875	COG0477	Major facilitator Superfamily
ER45_021880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ER45_021900	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ER45_021905	COG0735	belongs to the Fur family
ER45_021910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ER45_021915	COG1121	(ABC) transporter
ER45_021920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_021930	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ER45_021955	COG2384	SAM-dependent methyltransferase
ER45_021960	COG2010	Cytochrome c
ER45_021965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ER45_021970	COG0358	DNA primase activity
ER45_021985	COG0517	IMP dehydrogenase activity
ER45_021990	COG1381	Involved in DNA repair and RecF pathway recombination
ER45_022000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ER45_022005	COG0295	cytidine deaminase activity
ER45_022010	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ER45_022015	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ER45_022025	COG1702	phosphate starvation-inducible protein PhoH
ER45_022040	COG1610	YqeY-like protein
ER45_022045	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ER45_022050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ER45_022055	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ER45_022065	COG0484	heat shock protein binding
ER45_022070	COG0443	Heat shock 70 kDa protein
ER45_022080	COG1420	regulation of RNA biosynthetic process
ER45_022085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ER45_022090	COG1733	regulation of RNA biosynthetic process
ER45_022095	COG0481	GTPase activity
ER45_022105	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ER45_022110	COG0268	Binds directly to 16S ribosomal RNA
ER45_022125	COG0658	competence protein
ER45_022125	COG2333	competence protein COMEC
ER45_022130	COG2131	deaminase
ER45_022135	COG1555	photosystem II stabilization
ER45_022135	COG1596	polysaccharide export
ER45_022140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ER45_022145	COG2226	methyltransferase
ER45_022150	COG0799	negative regulation of ribosome biogenesis
ER45_022155	COG1713	HD superfamily hydrolase involved in NAD metabolism
ER45_022160	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ER45_022165	COG1534	Rna-binding protein
ER45_022170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ER45_022175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ER45_022180	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ER45_022190	COG0688	phosphatidylethanolamine metabolic process
ER45_022200	COG1595	DNA-templated transcription, initiation
ER45_022205	COG2357	RelA SpoT domain protein
ER45_022215	COG1785	Belongs to the alkaline phosphatase family
ER45_022225	COG2267	carboxylic ester hydrolase activity
ER45_022260	COG1404	Belongs to the peptidase S8 family
ER45_022265	COG3186	Phenylalanine-4-hydroxylase
ER45_022270	COG2154	pterin-4-alpha-carbinolamine dehydratase
ER45_022275	COG2514	catechol 2,3-dioxygenase activity
ER45_022280	COG2259	Doxx family
ER45_022320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_022330	COG1012	belongs to the aldehyde dehydrogenase family
ER45_022330	COG1454	alcohol dehydrogenase
ER45_022335	COG0626	cystathionine gamma-synthase activity
ER45_022340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ER45_022345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ER45_022350	COG2226	methyltransferase
ER45_022370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ER45_022375	COG0572	uridine kinase
ER45_022380	COG0826	peptidase U32
ER45_022385	COG0826	peptidase U32
ER45_022390	COG4122	O-methyltransferase activity
ER45_022395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ER45_022405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ER45_022410	COG4472	Bacterial protein of unknown function (DUF965)
ER45_022415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ER45_022425	COG0628	permease
ER45_022445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ER45_022455	COG0482	sulfurtransferase activity
ER45_022460	COG1104	cysteine desulfurase activity
ER45_022465	COG1959	2 iron, 2 sulfur cluster binding
ER45_022470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ER45_022480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ER45_022485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ER45_022500	COG1490	D-aminoacyl-tRNA deacylase activity
ER45_022505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ER45_022510	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ER45_022515	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ER45_022515	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ER45_022520	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ER45_022525	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ER45_022525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ER45_022535	COG2244	polysaccharide biosynthetic process
ER45_022540	COG2323	membrane
ER45_022550	COG1862	Preprotein translocase
ER45_022560	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ER45_022570	COG2255	four-way junction helicase activity
ER45_022575	COG0632	four-way junction helicase activity
ER45_022580	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ER45_022610	COG0157	Belongs to the NadC ModD family
ER45_022615	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ER45_022625	COG1827	regulation of RNA biosynthetic process
ER45_022630	COG2258	MOSC domain
ER45_022635	COG0077	Prephenate dehydratase
ER45_022645	COG0577	efflux transmembrane transporter activity
ER45_022650	COG1136	(ABC) transporter
ER45_022655	COG5002	protein histidine kinase activity
ER45_022660	COG0745	RESPONSE REGULATOR receiver
ER45_022665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ER45_022670	COG3290	protein histidine kinase activity
ER45_022680	COG2868	ribosomal protein
ER45_022690	COG1530	ribonuclease E activity
ER45_022695	COG1994	Peptidase M50
ER45_022700	COG0739	heme binding
ER45_022705	COG2894	cell division
ER45_022710	COG0850	regulation of cytokinetic process
ER45_022725	COG1077	Cell shape determining protein MreB Mrl
ER45_022730	COG2003	Belongs to the UPF0758 family
ER45_022735	COG0424	maF-like protein
ER45_022745	COG0285	dihydrofolate synthase activity
ER45_022760	COG1388	LysM domain
ER45_022765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ER45_022770	COG0113	porphobilinogen synthase activity
ER45_022775	COG1587	Uroporphyrinogen-III synthase
ER45_022780	COG0181	hydroxymethylbilane synthase activity
ER45_022785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ER45_022790	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ER45_022795	COG1846	Transcriptional regulator
ER45_022800	COG1764	response to oxidative stress
ER45_022805	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ER45_022815	COG0470	DNA polymerase III
ER45_022815	COG1067	ATP-dependent peptidase activity
ER45_022825	COG0544	peptidyl-prolyl cis-trans isomerase activity
ER45_022855	COG0622	Phosphoesterase
ER45_022865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ER45_022870	COG5401	PFAM Sporulation and spore germination
ER45_022880	COG0477	Major facilitator Superfamily
ER45_022885	COG2197	response regulator
ER45_022890	COG2233	PERMEase
ER45_022895	COG0402	S-adenosylhomocysteine deaminase activity
ER45_022900	COG1983	PspC domain protein
ER45_022905	COG1396	sequence-specific DNA binding
ER45_022920	COG1959	2 iron, 2 sulfur cluster binding
ER45_022925	COG1668	transmembrane transport
ER45_022930	COG4152	abc transporter atp-binding protein
ER45_022940	COG1360	Flagellar Motor Protein
ER45_022945	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ER45_022950	COG1876	peptidase activity
ER45_022955	COG0824	Thioesterase
ER45_022960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ER45_022965	COG1053	succinate dehydrogenase
ER45_022970	COG2009	succinate dehydrogenase
ER45_022975	COG1719	4-vinyl reductase, 4VR
ER45_022980	COG0322	excinuclease ABC activity
ER45_022985	COG3118	belongs to the thioredoxin family
ER45_022990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ER45_022995	COG2086	electron transfer activity
ER45_023000	COG1024	Enoyl-CoA hydratase
ER45_023005	COG1309	transcriptional regulator
ER45_023010	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_023035	COG2318	DinB family
ER45_023065	COG2205	protein histidine kinase activity
ER45_023070	COG0745	RESPONSE REGULATOR receiver
ER45_023080	COG4895	conserved protein (DUF2196)
ER45_023085	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ER45_023095	COG4509	Sortase family
ER45_023125	COG5386	Cell surface protein
ER45_023130	COG1114	Component of the transport system for branched-chain amino acids
ER45_023140	COG1193	negative regulation of DNA recombination
ER45_023145	COG1796	DNA polymerase
ER45_023145	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ER45_023150	COG1286	toxin biosynthetic process
ER45_023155	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ER45_023160	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ER45_023185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ER45_023190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ER45_023200	COG1418	mRNA catabolic process
ER45_023230	COG2814	Major facilitator Superfamily
ER45_023235	COG1566	PFAM secretion protein HlyD family protein
ER45_023240	COG1309	transcriptional regulator
ER45_023245	COG1363	Peptidase, m42
ER45_023270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ER45_023280	COG1484	DNA-dependent DNA replication
ER45_023285	COG3611	Membrane attachment protein
ER45_023290	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ER45_023295	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ER45_023300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ER45_023305	COG0237	dephospho-CoA kinase activity
ER45_023310	COG1971	Probably functions as a manganese efflux pump
ER45_023320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ER45_023320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ER45_023325	COG5002	protein histidine kinase activity
ER45_023330	COG0745	RESPONSE REGULATOR receiver
ER45_023345	COG0039	L-malate dehydrogenase activity
ER45_023350	COG0538	isocitrate dehydrogenase activity
ER45_023355	COG0372	Belongs to the citrate synthase family
ER45_023365	COG0628	permease
ER45_023370	COG3030	protein affecting phage T7 exclusion by the F plasmid
ER45_023380	COG0205	6-phosphofructokinase activity
ER45_023390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ER45_023395	COG1725	Transcriptional regulator
ER45_023400	COG0281	malic enzyme
ER45_023405	COG0587	DNA-directed DNA polymerase activity
ER45_023420	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ER45_023435	COG4109	DRTGG domain
ER45_023450	COG0006	proline dipeptidase activity
ER45_023480	COG0662	Cupin 2, conserved barrel domain protein
ER45_023490	COG1476	TRANSCRIPTIONal
ER45_023505	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_023510	COG0589	response to stress
ER45_023530	COG0165	Argininosuccinate lyase
ER45_023550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_023570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ER45_023575	COG0827	DNA restriction-modification system
ER45_023585	COG3874	Sporulation protein YtfJ
ER45_023600	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ER45_023610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ER45_023625	COG1104	cysteine desulfurase activity
ER45_023630	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ER45_023645	COG1309	transcriptional regulator
ER45_023650	COG1956	GAF domain-containing protein
ER45_023655	COG0626	cystathionine gamma-synthase activity
ER45_023660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ER45_023685	COG1595	DNA-templated transcription, initiation
ER45_023695	COG0110	maltose O-acetyltransferase activity
ER45_023700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ER45_023705	COG0454	-acetyltransferase
ER45_023710	COG0517	IMP dehydrogenase activity
ER45_023730	COG0745	RESPONSE REGULATOR receiver
ER45_023740	COG0666	response to abiotic stimulus
ER45_023750	COG1970	mechanosensitive ion channel activity
ER45_023775	COG1609	Transcriptional regulator
ER45_023785	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ER45_023785	COG1605	Chorismate mutase
ER45_023790	COG4851	CamS sex pheromone cAM373 precursor
ER45_023795	COG3118	belongs to the thioredoxin family
ER45_023805	COG2309	aminopeptidase activity
ER45_023835	COG0697	spore germination
ER45_023840	COG0789	Transcriptional regulator
ER45_023845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ER45_023870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ER45_023875	COG4848	Belongs to the UPF0354 family
ER45_023880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ER45_023885	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
ER45_023890	COG1363	Peptidase, m42
ER45_023900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_023905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ER45_023915	COG0510	thiamine kinase activity
ER45_023920	COG1523	belongs to the glycosyl hydrolase 13 family
ER45_023930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ER45_023935	COG1349	DNA-binding transcription factor activity
ER45_023940	COG1187	pseudouridine synthase activity
ER45_023945	COG2244	polysaccharide biosynthetic process
ER45_023950	COG2081	HI0933 family
ER45_023965	COG3832	glyoxalase III activity
ER45_024010	COG0314	molybdopterin synthase activity
ER45_024015	COG1763	Mo-molybdopterin cofactor biosynthetic process
ER45_024030	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ER45_024055	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ER45_024065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ER45_024105	COG0495	leucyl-tRNA aminoacylation
ER45_024115	COG0475	glutathione-regulated potassium exporter activity
ER45_024120	COG0490	domain, Protein
ER45_024125	COG0582	viral genome integration into host DNA
ER45_024135	COG1136	(ABC) transporter
ER45_024150	COG1242	4 iron, 4 sulfur cluster binding
ER45_024155	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ER45_024160	COG1131	(ABC) transporter
ER45_024170	COG1794	racemase activity, acting on amino acids and derivatives
ER45_024185	COG2267	carboxylic ester hydrolase activity
ER45_024190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ER45_024195	COG0671	phosphoesterase, PA-phosphatase related
ER45_024200	COG0438	transferase activity, transferring glycosyl groups
ER45_024210	COG0521	Mo-molybdopterin cofactor biosynthetic process
ER45_024235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ER45_024280	COG5002	protein histidine kinase activity
ER45_024285	COG3852	Histidine kinase
ER45_024290	COG0753	catalase activity
ER45_024295	COG2267	carboxylic ester hydrolase activity
ER45_024305	COG1368	sulfuric ester hydrolase activity
ER45_024315	COG4895	conserved protein (DUF2196)
ER45_024330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ER45_024335	COG1116	anion transmembrane transporter activity
ER45_024340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ER45_024365	COG0494	nUDIX hydrolase
ER45_024400	COG2076	Multidrug Resistance protein
ER45_024405	COG2076	Multidrug Resistance protein
ER45_024410	COG0789	Transcriptional regulator
ER45_024415	COG1854	S-ribosylhomocysteine lyase activity
ER45_024425	COG0288	reversible hydration of carbon dioxide
ER45_024430	COG1271	oxidase subunit
ER45_024435	COG1294	oxidase, subunit
ER45_024455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ER45_024475	COG1842	Phage shock protein A
ER45_024500	COG3859	Proton-coupled thiamine transporter YuaJ
ER45_024505	COG5002	protein histidine kinase activity
ER45_024510	COG0745	RESPONSE REGULATOR receiver
ER45_024535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ER45_024540	COG1597	lipid kinase activity
ER45_024570	COG1136	(ABC) transporter
ER45_024600	COG5002	protein histidine kinase activity
ER45_024625	COG0577	efflux transmembrane transporter activity
ER45_024630	COG1136	(ABC) transporter
ER45_024635	COG2207	Transcriptional regulator
ER45_024635	COG3708	Transcriptional regulator
ER45_024645	COG1131	(ABC) transporter
ER45_024655	COG5658	integral membrane protein
ER45_024660	COG0640	Transcriptional regulator
ER45_024665	COG0745	RESPONSE REGULATOR receiver
ER45_024670	COG2205	protein histidine kinase activity
ER45_024675	COG0577	efflux transmembrane transporter activity
ER45_024680	COG0577	efflux transmembrane transporter activity
ER45_024690	COG0577	efflux transmembrane transporter activity
ER45_024705	COG2188	Transcriptional regulator
ER45_024725	COG3964	amidohydrolase
ER45_024745	COG4948	Mandelate Racemase Muconate Lactonizing
ER45_024750	COG0318	PFAM AMP-dependent synthetase and ligase
ER45_024755	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ER45_024765	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ER45_024770	COG1169	isochorismate synthase
ER45_024775	COG1575	Belongs to the MenA family. Type 1 subfamily
ER45_024780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ER45_024785	COG1278	Cold shock
ER45_024795	COG0789	Transcriptional regulator
ER45_024805	COG0058	SHG alpha-glucan phosphorylase activity
ER45_024815	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ER45_024820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ER45_024825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ER45_024850	COG1595	DNA-templated transcription, initiation
ER45_024985	COG1285	pathogenesis
ER45_024990	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ER45_025000	COG0166	Belongs to the GPI family
ER45_025005	COG2155	Conserved Protein
ER45_025010	COG1098	S1 RNA binding domain
ER45_025015	COG0436	Aminotransferase
ER45_025020	COG1522	sequence-specific DNA binding
ER45_025025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ER45_025040	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ER45_025060	COG5018	Exonuclease
ER45_025085	COG2050	protein possibly involved in aromatic compounds catabolism
ER45_025095	COG1268	BioY protein
ER45_025100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ER45_025105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ER45_025115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ER45_025120	COG3584	3D domain protein
ER45_025135	COG1252	NADH dehydrogenase
ER45_025140	COG0492	ferredoxin-NADP+ reductase activity
ER45_025145	COG3708	Transcriptional regulator
ER45_025160	COG1683	Conserved Protein
ER45_025180	COG0316	Belongs to the HesB IscA family
ER45_025185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ER45_025190	COG4844	belongs to the
ER45_025195	COG1252	NADH dehydrogenase
ER45_025200	COG2274	protein secretion by the type I secretion system
ER45_025205	COG0390	transport system, permease component
ER45_025210	COG2824	Alkylphosphonate utilization operon protein PhnA
ER45_025240	COG4837	Protein of unknown function (DUF1462)
ER45_025245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ER45_025255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ER45_025260	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ER45_025275	COG0577	efflux transmembrane transporter activity
ER45_025275	COG1136	(ABC) transporter
ER45_025280	COG2249	NAD(P)H dehydrogenase (quinone) activity
ER45_025290	COG0647	UMP catabolic process
ER45_025300	COG2445	Protein of unknown function DUF86
ER45_025320	COG4470	Protein conserved in bacteria
ER45_025330	COG0789	Transcriptional regulator
ER45_025335	COG4377	Putative membrane peptidase family (DUF2324)
ER45_025355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ER45_025360	COG0739	heme binding
ER45_025370	COG3377	Domain of unknown function (DUF1805)
ER45_025375	COG0737	Belongs to the 5'-nucleotidase family
ER45_025380	COG0719	Fe-S assembly protein
ER45_025385	COG0822	iron-sulfur transferase activity
ER45_025390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ER45_025395	COG0719	Fe-S assembly protein
ER45_025400	COG0396	ATPase activity
ER45_025405	COG1464	Belongs to the NlpA lipoprotein family
ER45_025410	COG1464	Belongs to the NlpA lipoprotein family
ER45_025415	COG2011	ABC-type metal ion transport system permease component
ER45_025420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ER45_025430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ER45_025435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ER45_025440	COG0509	glycine decarboxylation via glycine cleavage system
ER45_025445	COG1393	Belongs to the ArsC family
ER45_025480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ER45_025485	COG1960	acyl-CoA dehydrogenase activity
ER45_025490	COG0183	Belongs to the thiolase family
ER45_025495	COG1250	3-hydroxyacyl-CoA dehydrogenase
ER45_025495	COG1024	Enoyl-CoA hydratase
ER45_025510	COG0506	proline dehydrogenase activity
ER45_025520	COG0011	TIGRFAM Protein of
ER45_025525	COG0840	transmembrane signaling receptor activity
ER45_025540	COG2814	Major facilitator Superfamily
ER45_025545	COG0531	amino acid
ER45_025610	COG0586	Pfam SNARE associated Golgi protein
ER45_025620	COG1376	ErfK ybiS ycfS ynhG family protein
ER45_025625	COG0745	RESPONSE REGULATOR receiver
ER45_025630	COG5002	protein histidine kinase activity
ER45_025640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ER45_025655	COG0840	transmembrane signaling receptor activity
ER45_025660	COG2151	metal-sulfur cluster biosynthetic enzyme
ER45_025665	COG3227	Zinc metalloprotease (Elastase)
ER45_025670	COG1741	Belongs to the pirin family
ER45_025685	COG0586	Pfam SNARE associated Golgi protein
ER45_025690	COG0475	glutathione-regulated potassium exporter activity
ER45_025695	COG0490	domain, Protein
ER45_025700	COG1115	amino acid carrier protein
ER45_025705	COG0783	Belongs to the Dps family
ER45_025715	COG2318	DinB family
ER45_025720	COG1611	Belongs to the LOG family
ER45_025730	COG1528	Iron-storage protein
ER45_025735	COG2311	Membrane
ER45_025740	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_025745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_025750	COG1115	amino acid carrier protein
ER45_025755	COG1115	amino acid carrier protein
ER45_025760	COG2910	NAD(P)H-binding
ER45_025770	COG0656	L-ascorbic acid biosynthetic process
ER45_025775	COG2814	Major facilitator Superfamily
ER45_025780	COG1733	regulation of RNA biosynthetic process
ER45_025790	COG1252	NADH dehydrogenase
ER45_025820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ER45_025855	COG4224	UPF0291 protein
ER45_025860	COG1335	isochorismatase
ER45_025865	COG1522	sequence-specific DNA binding
ER45_025875	COG1522	sequence-specific DNA binding
ER45_025880	COG0288	reversible hydration of carbon dioxide
ER45_025885	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
ER45_025915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_025930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ER45_025935	COG0557	exoribonuclease II activity
ER45_025940	COG1647	Serine aminopeptidase, S33
ER45_025945	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ER45_025950	COG1346	cytolysis
ER45_025965	COG0148	phosphopyruvate hydratase activity
ER45_025980	COG0126	phosphoglycerate kinase activity
ER45_025985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ER45_026000	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ER45_026035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ER45_026050	COG2323	membrane
ER45_026060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ER45_026065	COG1481	regulation of sporulation
ER45_026070	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ER45_026075	COG1660	Displays ATPase and GTPase activities
ER45_026080	COG1051	belongs to the nudix hydrolase family
ER45_026090	COG0492	ferredoxin-NADP+ reductase activity
ER45_026095	COG0457	Tetratricopeptide repeat
ER45_026100	COG0110	maltose O-acetyltransferase activity
ER45_026105	COG0546	phosphoglycolate phosphatase activity
ER45_026110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ER45_026115	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ER45_026120	COG1950	PFAM Membrane protein of
ER45_026125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ER45_026145	COG0789	Transcriptional regulator
ER45_026180	COG0583	DNA-binding transcription factor activity
ER45_026185	COG0789	Transcriptional regulator
ER45_026190	COG0655	NAD(P)H dehydrogenase (quinone) activity
ER45_026195	COG0488	(ABC) transporter
ER45_026205	COG1132	(ABC) transporter
ER45_026210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ER45_026215	COG0793	Belongs to the peptidase S41A family
ER45_026215	COG3409	Peptidoglycan-binding domain 1 protein
ER45_026220	COG2177	Part of the ABC transporter FtsEX involved in
ER45_026225	COG2884	Cell division ATP-binding protein ftsE
ER45_026250	COG1131	(ABC) transporter
ER45_026285	COG1278	Cold shock
ER45_026290	COG1040	competence protein
ER45_026295	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ER45_026300	COG0791	NLP P60 protein
ER45_026300	COG1388	LysM domain
ER45_026305	COG1733	regulation of RNA biosynthetic process
ER45_026310	COG1307	EDD domain protein, DegV family
ER45_026315	COG1739	Uncharacterized protein family UPF0029
ER45_026320	COG1316	TRANSCRIPTIONal
ER45_026325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ER45_026335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ER45_026345	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ER45_026345	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ER45_026365	COG1486	melibiose metabolic process
ER45_026370	COG1447	Phosphotransferase system cellobiose-specific component IIA
ER45_026395	COG1447	Phosphotransferase system cellobiose-specific component IIA
ER45_026405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ER45_026410	COG1301	dicarboxylic acid transport
ER45_026425	COG1511	domain protein
ER45_026430	COG0583	DNA-binding transcription factor activity
ER45_026435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ER45_026445	COG1271	oxidase subunit
ER45_026450	COG1294	oxidase, subunit
ER45_026460	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ER45_026465	COG1620	l-lactate permease
ER45_026475	COG2389	metal-binding protein
ER45_026485	COG1368	sulfuric ester hydrolase activity
ER45_026495	COG1388	LysM domain
ER45_026495	COG0791	NLP P60 protein
ER45_026500	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_026510	COG1215	transferase activity, transferring glycosyl groups
ER45_026515	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ER45_026520	COG3584	3D domain protein
ER45_026520	COG1388	LysM domain
ER45_026545	COG4715	Zinc finger, swim domain protein
ER45_026550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ER45_026590	COG0577	efflux transmembrane transporter activity
ER45_026595	COG1136	(ABC) transporter
ER45_026620	COG3850	Histidine kinase
ER45_026620	COG5002	protein histidine kinase activity
ER45_026625	COG0745	RESPONSE REGULATOR receiver
ER45_026640	COG1091	dTDP-4-dehydrorhamnose reductase activity
ER45_026655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ER45_026675	COG0110	maltose O-acetyltransferase activity
ER45_026690	COG0438	transferase activity, transferring glycosyl groups
ER45_026695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ER45_026705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ER45_026715	COG0489	protein tyrosine kinase activity
ER45_026725	COG0489	protein tyrosine kinase activity
ER45_026740	COG1609	Transcriptional regulator
ER45_026750	COG0739	heme binding
ER45_026765	COG3279	Response regulator of the LytR AlgR family
ER45_026770	COG2385	sporulation resulting in formation of a cellular spore
ER45_026785	COG4836	Membrane
ER45_026790	COG1007	ATP synthesis coupled electron transport
ER45_026795	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ER45_026800	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ER45_026805	COG0713	ATP synthesis coupled electron transport
ER45_026820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ER45_026825	COG0649	NAD binding
ER45_026835	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ER45_026840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ER45_026845	COG5001	Diguanylate cyclase
ER45_026845	COG3300	MHYT domain
ER45_026860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ER45_026870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ER45_026875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ER45_026880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ER45_026885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ER45_026895	COG0356	it plays a direct role in the translocation of protons across the membrane
ER45_026920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ER45_026930	COG0698	ribose 5-phosphate isomerase
ER45_026940	COG2190	(PTS) system
ER45_026945	COG2259	Doxx family
ER45_026950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ER45_026960	COG1971	Probably functions as a manganese efflux pump
ER45_026965	COG0009	L-threonylcarbamoyladenylate synthase
ER45_026980	COG2890	protein-(glutamine-N5) methyltransferase activity
ER45_026990	COG1435	thymidine kinase activity
ER45_027000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ER45_027005	COG1494	fructose-1,6-bisphosphatase
ER45_027025	COG4821	SIS domain
ER45_027030	COG0504	CTP synthase activity
ER45_027035	COG3343	RNA polymerase activity
ER45_027045	COG1960	acyl-CoA dehydrogenase activity
ER45_027050	COG1960	acyl-CoA dehydrogenase activity
ER45_027055	COG1250	3-hydroxyacyl-CoA dehydrogenase
ER45_027065	COG2181	nitrate reductase activity
ER45_027065	COG0247	lactate metabolic process
ER45_027070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ER45_027080	COG3300	MHYT domain
ER45_027080	COG5001	Diguanylate cyclase
ER45_027100	COG2197	response regulator
ER45_027105	COG4585	Histidine kinase
ER45_027110	COG0842	Transport permease protein
ER45_027115	COG1131	(ABC) transporter
ER45_027120	COG0024	Methionine aminopeptidase
ER45_027125	COG2234	aminopeptidase activity
ER45_027140	COG4506	Protein conserved in bacteria
ER45_027145	COG1619	proteins homologs of microcin C7 resistance protein MccF
ER45_027160	COG0010	Belongs to the arginase family
ER45_027165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ER45_027170	COG2814	Major facilitator Superfamily
ER45_027175	COG0789	Transcriptional regulator
ER45_027180	COG0584	glycerophosphoryl diester phosphodiesterase
ER45_027185	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ER45_027195	COG1994	Peptidase M50
ER45_027210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ER45_027215	COG1120	ATPase activity
ER45_027220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_027225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ER45_027230	COG4844	belongs to the
ER45_027245	COG0280	phosphate acetyltransferase
ER45_027250	COG3253	May function as heme-dependent peroxidase
ER45_027260	COG3773	Cell wall hydrolase
ER45_027270	COG2363	Small membrane protein
ER45_027285	COG2233	PERMEase
ER45_027290	COG0561	phosphatase activity
ER45_027295	COG2814	Major facilitator Superfamily
ER45_027300	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ER45_027305	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ER45_027310	COG1131	(ABC) transporter
ER45_027315	COG2755	lipolytic protein G-D-S-L family
ER45_027320	COG1609	Transcriptional regulator
ER45_027330	COG0460	homoserine dehydrogenase
ER45_027335	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ER45_027340	COG2873	o-acetylhomoserine
ER45_027355	COG2197	response regulator
ER45_027360	COG2203	Gaf domain
ER45_027360	COG4585	Histidine kinase
ER45_027365	COG0351	phosphomethylpyrimidine kinase
ER45_027370	COG3706	GGDEF domain
ER45_027375	COG2879	small protein
ER45_027380	COG1966	Carbon starvation protein
ER45_027390	COG0477	Major facilitator Superfamily
ER45_027415	COG0840	transmembrane signaling receptor activity
ER45_027425	COG1607	acyl-coa hydrolase
ER45_027430	COG1216	Glycosyl transferase, family 2
ER45_027440	COG1216	Glycosyl transferase, family 2
ER45_027455	COG0463	Glycosyl transferase, family 2
ER45_027465	COG1309	transcriptional regulator
ER45_027470	COG0488	(ABC) transporter
ER45_027475	COG1309	transcriptional regulator
ER45_027480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ER45_027490	COG0628	permease
ER45_027500	COG1380	Effector of murein hydrolase LrgA
ER45_027505	COG3279	Response regulator of the LytR AlgR family
ER45_027510	COG3275	phosphorelay sensor kinase activity
ER45_027515	COG2814	Major facilitator Superfamily
ER45_027520	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ER45_027525	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ER45_027530	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ER45_027580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ER45_027585	COG1272	protein, Hemolysin III
ER45_027620	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ER45_027630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ER45_027635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ER45_027640	COG4853	Protein conserved in bacteria
ER45_027650	COG5002	protein histidine kinase activity
ER45_027655	COG0745	RESPONSE REGULATOR receiver
ER45_027685	COG0305	Participates in initiation and elongation during chromosome replication
ER45_027690	COG0359	binds to the 23S rRNA
ER45_027695	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ER45_027700	COG4241	membrane
ER45_027710	COG0629	single-stranded DNA binding
ER45_027715	COG0360	Binds together with S18 to 16S ribosomal RNA
ER45_027720	COG0012	GTP binding
ER45_027725	COG4481	Protein conserved in bacteria
ER45_027730	COG0668	transmembrane transport
ER45_027740	COG1475	DNA binding
ER45_027745	COG1192	Involved in chromosome partitioning
ER45_027755	COG0357	Ribosomal RNA small subunit methyltransferase G
ER45_027760	COG0445	tRNA wobble uridine modification
ER45_027765	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ER45_027770	COG1847	R3H domain protein
ER45_027775	COG0706	membrane insertase activity
ER45_027780	COG0594	ribonuclease P activity
ER45_027785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ER45_027800	COG2356	endonuclease I
ER45_027815	COG2801	Transposase and inactivated derivatives
ER45_027825	COG1335	isochorismatase
ER45_027860	COG0745	RESPONSE REGULATOR receiver
ER45_027875	COG1794	racemase activity, acting on amino acids and derivatives
ER45_027890	COG2814	Major facilitator Superfamily
ER45_027905	COG0697	spore germination
ER45_027910	COG2197	response regulator
ER45_027930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ER45_027935	COG0697	spore germination
ER45_027950	COG1104	cysteine desulfurase activity
ER45_027955	COG2843	Capsule synthesis protein
ER45_027960	COG1876	peptidase activity
ER45_027970	COG2801	Transposase and inactivated derivatives
ER45_027985	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ER45_027985	COG2199	diguanylate cyclase activity
ER45_028050	COG3104	oligopeptide transport
ER45_028090	COG0069	glutamate synthase activity
ER45_028095	COG0745	RESPONSE REGULATOR receiver
ER45_028100	COG0768	penicillin binding
ER45_028105	COG1686	Belongs to the peptidase S11 family
ER45_028115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ER45_028145	COG2807	transmembrane transport
ER45_028150	COG2807	transmembrane transport
ER45_028165	COG1346	cytolysis
ER45_028175	COG0583	DNA-binding transcription factor activity
ER45_028190	COG1607	acyl-coa hydrolase
ER45_028195	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ER45_028205	COG1252	NADH dehydrogenase
ER45_028290	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ER45_028290	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ER45_028305	COG0745	RESPONSE REGULATOR receiver
ER45_028340	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ER45_028360	COG1136	(ABC) transporter
ER45_028375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ER45_028400	COG2205	protein histidine kinase activity
ER45_028410	COG1136	(ABC) transporter
ER45_028440	COG1132	(ABC) transporter
ER45_028470	COG0463	Glycosyl transferase, family 2
ER45_028475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ER45_028490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ER45_028505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ER45_028520	COG1132	(ABC) transporter
ER45_028535	COG0583	DNA-binding transcription factor activity
ER45_028555	COG3584	3D domain protein
ER45_028560	COG5002	protein histidine kinase activity
ER45_028565	COG0745	RESPONSE REGULATOR receiver
ER45_028575	COG1408	metallophosphoesterase
ER45_028600	COG0772	Belongs to the SEDS family
ER45_028630	COG1923	regulation of RNA biosynthetic process
ER45_028665	COG1696	Membrane protein involved in D-alanine export
ER45_028730	COG0028	Belongs to the TPP enzyme family
ER45_028810	COG0366	Alpha amylase catalytic
ER45_028810	COG5263	repeat protein
ER45_028840	COG4974	Belongs to the 'phage' integrase family
ER45_028915	COG1252	NADH dehydrogenase
ER45_028920	COG2706	6-phosphogluconolactonase activity
ER45_028925	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ER45_028940	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ER45_028975	COG1136	(ABC) transporter
ER45_029025	COG0076	glutamate decarboxylase activity
ER45_029045	COG2814	Major facilitator Superfamily
ER45_029050	COG3584	3D domain protein
ER45_029060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
ER45_029105	COG2801	Transposase and inactivated derivatives
ER45_029120	COG0577	efflux transmembrane transporter activity
ER45_029125	COG2002	toxin-antitoxin pair type II binding
ER45_029145	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ER45_029180	COG4499	WXG100 protein secretion system (Wss), protein YukC
ER45_029180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ER45_029295	COG5632	N-Acetylmuramoyl-L-alanine amidase
ER45_029340	COG0582	viral genome integration into host DNA
ER45_029385	COG0577	efflux transmembrane transporter activity
ER45_029390	COG1136	(ABC) transporter
ER45_029410	COG3486	L-lysine 6-monooxygenase (NADPH) activity
ER45_029440	COG2318	DinB family
ER45_029460	COG1605	Chorismate mutase
ER45_029460	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ER45_029520	COG1086	Polysaccharide biosynthesis protein
ER45_029540	COG1335	isochorismatase
ER45_029585	COG1845	cytochrome c oxidase, subunit III
ER45_029590	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ER45_029600	COG1028	Short-chain dehydrogenase reductase Sdr
ER45_029610	COG1612	heme a metabolic process
ER45_029650	COG2807	transmembrane transport
ER45_029725	COG2002	toxin-antitoxin pair type II binding
ER45_030005	COG1923	regulation of RNA biosynthetic process
ER45_030065	COG0823	Involved in the tonB-independent uptake of proteins
ER45_030075	COG1278	Cold shock
ER45_030150	COG0791	NLP P60 protein
ER45_030150	COG3883	PFAM NLP P60 protein
ER45_030160	COG0741	lytic transglycosylase activity
ER45_030160	COG0791	NLP P60 protein
ER45_030295	COG2801	Transposase and inactivated derivatives
ER45_030390	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
ER45_030400	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ER45_030490	COG0322	excinuclease ABC activity
ER45_030525	COG0582	viral genome integration into host DNA
ER45_030630	COG0860	N-Acetylmuramoyl-L-alanine amidase