locus-tag class description bwei_0009 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) bwei_0010 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin bwei_0013 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) bwei_0019 ENOG4107SWG transcriptional regulator MERR family bwei_0022 ENOG4105VEQ Cold shock protein bwei_0024 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase bwei_0025 ENOG4105E4F Isochorismate synthase bwei_0026 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) bwei_0027 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) bwei_0028 ENOG4108IPT Naphthoate synthase bwei_0029 ENOG4105CEY Amp-dependent synthetase and ligase bwei_0030 ENOG4105DTQ mandelate racemase muconate lactonizing bwei_0034 ENOG41069H0 dihydroorotase EC 3.5.2.3 bwei_0038 ENOG4105FDP GntR family transcriptional regulator bwei_0039 ENOG4105C6Z Gluconate bwei_0047 ENOG41082BM Transcriptional regulator, arsr family bwei_0050 ENOG4105CJ1 ABC, transporter bwei_0052 ENOG41086D8 Transcriptional regulator bwei_0053 ENOG4105C19 ABC transporter bwei_0057 ENOG4107ZTW SNARE associated Golgi bwei_0064 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) bwei_0065 ENOG4108UGV hypoxanthine phosphoribosyltransferase bwei_0070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_0071 ENOG4105BZU Histidine kinase bwei_0072 ENOG4105N67 Proton-coupled thiamine transporter YuaJ bwei_0077 ENOG41087YS Phage shock protein A bwei_0086 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii bwei_0087 ENOG4105C4M (Ubiquinol oxidase) subunit I bwei_0089 ENOG4108V2W Carbonate dehydratase bwei_0092 ENOG410839T multidrug resistance protein bwei_0093 ENOG41080TC multidrug resistance protein bwei_0101 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) bwei_0104 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component bwei_0106 ENOG4105D2X ABC transporter substrate-binding protein bwei_0112 ENOG4107T7U Sulfatase bwei_0114 ENOG4107S9D Alpha beta hydrolase bwei_0115 ENOG4105CH6 catalase bwei_0116 ENOG4105BZU Histidine kinase bwei_0117 ENOG4105BZU Histidine kinase bwei_0124 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase bwei_0125 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP bwei_0128 ENOG4105EPU Molybdenum cofactor synthesis domain protein bwei_0129 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) bwei_0130 ENOG4105BZF Glycosyl transferase (Group 1 bwei_0131 ENOG4105YVM Phosphoesterase, PA-phosphatase related bwei_0132 ENOG4108Z0R Transferase bwei_0133 ENOG4105E8V Alpha Beta Hydrolase Fold protein bwei_0138 ENOG4105DA5 (ABC) transporter bwei_0140 ENOG4105N5T Radical SAM Protein bwei_0144 ENOG4105C19 ABC transporter bwei_0147 ENOG4105NCW Trka-c domain protein bwei_0148 ENOG4107S91 Sodium hydrogen exchanger bwei_0149 ENOG410605W Major Facilitator bwei_0156 ENOG4108B31 Spore germination protein bwei_0158 ENOG4105DWV Homoserine O-trans-acetylase bwei_0160 ENOG41085GJ domain protein bwei_0164 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) bwei_0165 ENOG4105D06 uba thif-type nad fad binding protein bwei_0167 ENOG4105CVM Molybdenum cofactor synthesis domain protein bwei_0168 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b bwei_0169 ENOG4108ZAF Molybdopterin bwei_0173 ENOG4107EXU Short-chain dehydrogenase reductase Sdr bwei_0174 ENOG4108VJ1 Transcriptional regulator (CarD family bwei_0181 ENOG4105CBX hi0933 family bwei_0184 ENOG4105YW5 deoR family transcriptional regulator bwei_0185 ENOG4107QSE Dipeptidase bwei_0187 ENOG4108IUM Glycogen debranching enzyme bwei_0188 ENOG4108V15 phosphotransferase enzyme family bwei_0190 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) bwei_0191 ENOG4105C8F Beta-lactamase domain protein bwei_0197 ENOG4108VDD TRNA binding domain protein bwei_0202 ENOG4105DFU Cell wall formation (By similarity) bwei_0204 ENOG4105K7K Transcriptional regulator bwei_0208 ENOG4105C88 aminopeptidase bwei_0214 ENOG4105ETE Transcriptional regulator (LacI family bwei_0217 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) bwei_0218 ENOG4105EP9 oxidoreductase bwei_0219 ENOG4107SNB ankyrin repeat protein YahD bwei_0221 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bwei_0224 ENOG4105DGU Histone deacetylase bwei_0225 ENOG4105W87 Cbs domain bwei_0226 ENOG4105F1V Acetoin utilization protein bwei_0228 ENOG4108UW5 maltose o-acetyltransferase bwei_0231 ENOG4105EMN RNA polymerase sigma factor bwei_0236 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) bwei_0237 ENOG4105D7V transposase bwei_0238 ENOG4105C28 cystathionine bwei_0240 ENOG4105U5Y Transcriptional regulator bwei_0246 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) bwei_0248 ENOG4105EFZ amidohydrolase bwei_0251 ENOG4105KBJ sporulation protein ytfj bwei_0252 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) bwei_0255 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) bwei_0259 ENOG4108JYZ YitT family bwei_0262 ENOG4105CDH Citrulline--aspartate ligase bwei_0263 ENOG4105CH7 arginosuccinase bwei_0267 ENOG4107YZX Universal stress protein bwei_0271 ENOG4105VZ8 Transcriptional regulator bwei_0273 ENOG41082W1 Cupin 2, conserved barrel domain protein bwei_0281 ENOG4105DC7 peptidase M24 bwei_0282 ENOG4105E8R UPF0173 metal-dependent hydrolase bwei_0287 ENOG4105SFS phosphoesterase RecJ domain protein bwei_0289 ENOG4105VV2 bwei_0290 ENOG4105C0B DNA polymerase III (alpha subunit) bwei_0291 ENOG4105C6K Malic enzyme bwei_0292 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family bwei_0293 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) bwei_0295 ENOG4105CTQ phosphohexokinase bwei_0297 ENOG4105FS0 cytoplasmic membrane protein bwei_0298 ENOG4108REF Sporulation integral membrane protein ytvi bwei_0300 ENOG4105BZN citrate synthase bwei_0301 ENOG4108HMX isocitrate dehydrogenase (NADP) bwei_0303 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) bwei_0306 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bwei_0307 ENOG4105BZU Histidine kinase bwei_0308 ENOG4105C2M dna polymerase I bwei_0311 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) bwei_0312 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase bwei_0313 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) bwei_0317 ENOG4108TDW sporulation protein YtxC bwei_0318 ENOG4105C22 threonyL-tRNA synthetase bwei_0319 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) bwei_0321 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) bwei_0323 ENOG4105CN9 Peptidase m42 family protein bwei_0324 ENOG4108JGH Tetr family transcriptional regulator bwei_0325 ENOG4105CW7 secretion protein, HlyD family bwei_0326 ENOG4105C0R drug resistance transporter emrb qaca subfamily bwei_0334 ENOG4108RWN rrna methyltransferase bwei_0335 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) bwei_0336 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) bwei_0337 ENOG4105C5S asparaginyl-tRNA synthetase bwei_0340 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) bwei_0342 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) bwei_0344 ENOG4105DCG PHP domain protein bwei_0345 ENOG4105C98 muts2 protein bwei_0346 ENOG4105FE9 pseudouridine synthase bwei_0348 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) bwei_0349 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) bwei_0352 ENOG4105E0A ABC, transporter bwei_0353 ENOG4105KFN sortase, SrtB family bwei_0354 ENOG4105P9G heme-degrading monooxygenase IsdG bwei_0355 ENOG4105DR4 Methyltransferase bwei_0358 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bwei_0367 ENOG4105S6R Iron-hydroxamate transporter permease subunit bwei_0368 ENOG4105J76 Periplasmic binding protein bwei_0371 ENOG4105CEY Amp-dependent synthetase and ligase bwei_0372 ENOG4107Z3H Transcriptional regulator, TetR family bwei_0373 ENOG41060WC Enoyl-CoA hydratase bwei_0374 ENOG4105BZJ Electron transfer flavoprotein bwei_0375 ENOG4105C10 Electron transfer flavoprotein bwei_0376 ENOG4105K63 Thioredoxin bwei_0377 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) bwei_0379 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit bwei_0381 ENOG4105E33 succinate dehydrogenase bwei_0383 ENOG4108VXD carboxy-peptidase bwei_0384 ENOG4105E14 MotA TolQ exbB proton channel bwei_0385 ENOG4105ER2 Ompa motb domain protein bwei_0386 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family bwei_0387 ENOG4108IUX (ABC) transporter bwei_0388 ENOG4105RHA ABC transporter, permease bwei_0389 ENOG4108Z40 Transcriptional regulator bwei_0390 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) bwei_0392 ENOG4108JCI Transcriptional regulator bwei_0393 ENOG41067S9 phage shock protein C, PspC bwei_0394 ENOG4105DZC cytosine deaminase bwei_0396 ENOG4105PFC Transcriptional regulator bwei_0398 ENOG4108XJQ germination protein bwei_0399 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) bwei_0401 ENOG4105M59 Phosphodiesterase, mj0936 family bwei_0404 ENOG4108QCI YvbH-like oligomerisation region bwei_0408 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation bwei_0410 ENOG4108IUQ atp-dependent protease bwei_0412 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) bwei_0414 ENOG4105K56 Transcriptional regulator bwei_0416 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) bwei_0418 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) bwei_0420 ENOG4105D52 delta-aminolevulinic acid dehydratase bwei_0421 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase bwei_0422 ENOG41068KH stage VI sporulation protein D bwei_0424 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) bwei_0425 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase bwei_0427 ENOG4108Z03 MAF-like protein bwei_0428 ENOG4105W5Q DNA repair protein (RadC bwei_0429 ENOG4107Y5K Resolvase bwei_0440 ENOG4106CVF DNA replication protein bwei_0458 ENOG4105CAR Terminase, large subunit bwei_0460 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) bwei_0480 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bwei_0484 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bwei_0488 ENOG4105DFF Rod shape-determining protein mreb bwei_0489 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) bwei_0491 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) bwei_0492 ENOG4107QMS site-determining protein bwei_0495 ENOG4105C03 ribonuclease bwei_0497 ENOG4105X36 (ribosomal) protein bwei_0500 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control bwei_0502 ENOG4105EWM Histidine kinase bwei_0506 ENOG4105CQC Prephenate dehydratase bwei_0507 ENOG4108RPX mosc domain containing protein bwei_0510 ENOG4108IYU L-aspartate oxidase bwei_0511 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase bwei_0512 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) bwei_0517 ENOG4108HUF Transporter bwei_0518 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) bwei_0519 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) bwei_0520 ENOG41061AI Protein of unknown function (DUF2905) bwei_0522 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) bwei_0523 ENOG4105VIE preprotein translocase, subunit YajC bwei_0525 ENOG4108QG2 Membrane bwei_0526 ENOG4105CKP Polysaccharide Biosynthesis Protein bwei_0528 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) bwei_0529 ENOG41076HS cation diffusion facilitator family transporter bwei_0530 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) bwei_0531 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) bwei_0532 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) bwei_0533 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) bwei_0535 ENOG4105CUT histidyl-tRNA synthetase bwei_0538 ENOG4105CUZ uba thif-type nad fad binding protein bwei_0539 ENOG4108VCI transcription factor, rsfa family bwei_0540 ENOG4105D1H recombination factor protein RarA bwei_0542 ENOG4105C3J Cysteine desulfurase bwei_0543 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) bwei_0545 ENOG4105C7H Helicase, RecD TraA family bwei_0546 ENOG41060CR bwei_0549 ENOG4105C02 permease bwei_0551 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) bwei_0553 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) bwei_0555 ENOG4105HHA aminodeoxychorismate lyase bwei_0556 ENOG4108VQJ O-methyltransferase bwei_0557 ENOG4105XYU peptidase (U32 family) bwei_0558 ENOG4105CFP Peptidase U32 bwei_0559 ENOG4105DBI uridine monophosphokinase bwei_0561 ENOG4107XRG penicillin-binding protein bwei_0565 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) bwei_0567 ENOG4105C28 cystathionine bwei_0568 ENOG4108EKI Dehydrogenase bwei_0570 ENOG4108V5C ABC transporter bwei_0571 ENOG4105S6R Iron-hydroxamate transporter permease subunit bwei_0579 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_0580 ENOG4105KZX Pterin carbinolamine dehydratase bwei_0581 ENOG4105MIR Phenylalanine 4-monooxygenase bwei_0583 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin bwei_0590 ENOG4108MUZ hydrolase bwei_0592 ENOG4105G6Z alkaline phosphatase bwei_0596 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_0597 ENOG4105DJ4 phosphatidylserine decarboxylase bwei_0599 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase bwei_0600 ENOG4105CQW ribosome biogenesis GTPase YqeH bwei_0601 ENOG4105E2X shikimate dehydrogenase bwei_0602 ENOG410812S Rna-binding protein bwei_0603 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) bwei_0604 ENOG4108WF2 Metal Dependent Phosphohydrolase bwei_0606 ENOG4105DXX methyltransferase bwei_0608 ENOG4105KQC Competence protein bwei_0609 ENOG4108UK2 deaminase bwei_0610 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 bwei_0612 ENOG4105TQK DNA polymerase iii, delta' subunit bwei_0613 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) bwei_0614 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) bwei_0616 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) bwei_0617 ENOG4105KVH Transcriptional regulator bwei_0618 ENOG4105CSA Coproporphyrinogen iii oxidase bwei_0622 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) bwei_0624 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) bwei_0625 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) bwei_0627 ENOG4105KTH gatB Yqey bwei_0628 ENOG41068P3 sporulation protein YqfC bwei_0630 ENOG4105C9A Phoh family bwei_0631 ENOG4105CTJ Metal Dependent Phosphohydrolase bwei_0632 ENOG4107YVF Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) bwei_0633 ENOG4107YR5 Diacylglycerol kinase bwei_0634 ENOG4105KG3 cytidine deaminase bwei_0635 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) bwei_0637 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) bwei_0640 ENOG4107XJU UPF0178 protein bwei_0641 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) bwei_0642 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_0645 ENOG4105EGD dinuclear metal center protein, YbgI family bwei_0646 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) bwei_0650 ENOG41069ZM Protein of unknown function (DUF2624) bwei_0651 ENOG4108JYZ YitT family bwei_0652 ENOG4105FDK ABC transporter bwei_0654 ENOG4105N80 Ferric uptake regulator, Fur family bwei_0655 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) bwei_0661 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) bwei_0663 ENOG4107RF6 penicillin-binding protein bwei_0664 ENOG4105PWN phosphate abc transporter bwei_0665 ENOG4105C8U phosphate abc transporter bwei_0666 ENOG4105E2Z phosphate ABC transporter (Permease bwei_0667 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) bwei_0668 ENOG4108UTW Plays a role in the regulation of phosphate uptake bwei_0671 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase bwei_0673 ENOG4105DKQ ROK family bwei_0675 ENOG4105C5X domain protein bwei_0679 ENOG4105C28 cystathionine bwei_0680 ENOG4105C28 cystathionine bwei_0682 ENOG4105C3R Methionine synthase bwei_0702 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) bwei_0708 ENOG4105C0D helicase bwei_0709 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) bwei_0710 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor bwei_0711 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor bwei_0714 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family bwei_0721 ENOG41080TC multidrug resistance protein bwei_0726 ENOG4105WZW rhodanese family bwei_0727 ENOG41082GG biotin lipoate A B protein ligase bwei_0734 ENOG4107YBY Hydrolase bwei_0736 ENOG4105CBJ Metal-dependent enzyme bwei_0738 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) bwei_0739 ENOG4105DC7 peptidase M24 bwei_0740 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) bwei_0744 ENOG4105CD2 stage iii sporulation protein aa bwei_0745 ENOG4105KR5 Stage iii sporulation protein bwei_0746 ENOG4108CQH stage III sporulation protein AC bwei_0747 ENOG4105KQ4 Stage iii sporulation protein ad bwei_0749 ENOG410644B Stage III sporulation protein af bwei_0753 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase bwei_0754 ENOG4108ZSR alkaline shock protein bwei_0755 ENOG4105M7K Involved in the transcription termination process (By similarity) bwei_0756 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) bwei_0757 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) bwei_0758 ENOG41082UU Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) bwei_0759 ENOG4105CTB Polyprenyl synthetase bwei_0760 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) bwei_0761 ENOG4105DX0 Hemolysin A bwei_0763 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) bwei_0764 ENOG4105S1Z Stage IV sporulation protein B bwei_0766 ENOG4107QQR Sporulation bwei_0769 ENOG4108IBT Inherit from COG: transposase bwei_0777 ENOG4108QXE glycerophosphoryl diester phosphodiesterase bwei_0778 ENOG4106CCJ Protein of unknown function (DUF2627) bwei_0779 ENOG4108JUB Transcriptional regulator bwei_0781 ENOG4107RDP Dehydrogenase bwei_0785 ENOG4105CPP Dehydrogenase, E1 component bwei_0786 ENOG4105C7S Dehydrogenase bwei_0788 ENOG4108QY0 Membrane bwei_0789 ENOG4105E09 nadh pyrophosphatase bwei_0791 ENOG4108HW3 (ABC) transporter bwei_0792 ENOG4105E5Q amino acid AbC transporter bwei_0793 ENOG4105CDA abc transporter atp-binding protein bwei_0794 ENOG4108QEG Membrane bwei_0795 ENOG4108VZI ErfK ybiS ycfS ynhG family protein bwei_0797 ENOG4105D9U N-acetyltransferase bwei_0798 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) bwei_0803 ENOG4108RDQ ABC transporter bwei_0809 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) bwei_0812 ENOG4105EJQ L-serine dehydratase bwei_0813 ENOG4105II7 pyrroline-5-carboxylate reductase bwei_0814 ENOG41069FQ Metallo-beta-lactamase superfamily bwei_0815 ENOG4108IXY short-chain dehydrogenase reductase bwei_0817 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase bwei_0826 ENOG4105CGH 5'-nucleotidase bwei_0827 ENOG4105DFD Na H antiporter bwei_0829 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bwei_0831 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) bwei_0832 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bwei_0833 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bwei_0837 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) bwei_0838 ENOG4108R6K riboflavin synthase, subunit alpha bwei_0839 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) bwei_0843 ENOG4108YM7 Gcn5-related n-acetyltransferase bwei_0844 ENOG4105ETE Transcriptional regulator (LacI family bwei_0846 ENOG4107SKW Inherit from COG: Alpha beta hydrolase bwei_0851 ENOG4105RHY Pfam:UPF0157 bwei_0853 ENOG4105CPC Aldo Keto reductase bwei_0857 ENOG4105MZ9 stage II sporulation protein m bwei_0858 ENOG4105I3K Ferric uptake regulator, Fur family bwei_0860 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) bwei_0862 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) bwei_0865 ENOG4105D7N magnesium and cobalt transport protein CorA bwei_0872 ENOG4105DVE abc transporter atp-binding protein bwei_0873 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family bwei_0874 ENOG4105DZ1 carboxypeptidase bwei_0875 ENOG41082AN stage II sporulation protein bwei_0877 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_0878 ENOG4105C8J )-transporter bwei_0882 ENOG41090VF Stage v sporulation protein ac bwei_0883 ENOG4105CZ3 stage V sporulation protein ad bwei_0885 ENOG4105G6R Stage v sporulation protein ae bwei_0887 ENOG4105J7I hydrolase bwei_0888 ENOG4105PTM secreted protein bwei_0889 ENOG4107ZE5 PPIases accelerate the folding of proteins bwei_0893 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) bwei_0894 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) bwei_0896 ENOG4105CE4 GlcNAc 6-P deacetylase bwei_0898 ENOG4105FDP GntR family transcriptional regulator bwei_0900 ENOG4105CID antiterminator bwei_0903 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) bwei_0907 ENOG4105BZU Histidine kinase bwei_0909 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase bwei_0913 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) bwei_0917 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase bwei_0921 ENOG4105DTD Dehydrogenase bwei_0922 ENOG4105K7K Transcriptional regulator bwei_0928 ENOG4105CHU acetyl-coa acetyltransferase bwei_0929 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) bwei_0937 ENOG4105CG3 alpha amylase, catalytic region bwei_0939 ENOG4107FKK extracellular solute-binding protein family 1 bwei_0941 ENOG4105EG2 ABC transporter, permease bwei_0942 ENOG4105FKQ transcriptional regulator bwei_0943 ENOG4105CHM Aminotransferase bwei_0945 ENOG4108HGU Histidine kinase bwei_0949 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) bwei_0956 ENOG4105UIN bwei_0958 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) bwei_0962 ENOG4105K6S Short-chain dehydrogenase reductase Sdr bwei_0963 ENOG4105EPM Diguanylate phosphodiesterase bwei_0966 ENOG4107IN1 Protein of unknown function (DUF1797) bwei_0968 ENOG4108XRC Protein of unknown function (DUF458) bwei_0972 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) bwei_0975 ENOG4107ZYR domain protein bwei_0976 ENOG4105CN5 Metallo-Beta-Lactamase bwei_0978 ENOG4108X4Q Hydrolase bwei_0979 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) bwei_0982 ENOG4105CPP Dehydrogenase, E1 component bwei_0983 ENOG4105C7S Dehydrogenase bwei_0992 ENOG4105CXN decarboxylase bwei_0993 ENOG4105WBI UPF0223 protein bwei_0994 ENOG4108WQ8 UPF0637 protein bwei_0996 ENOG4105ECY inositol monophosphatase bwei_0998 ENOG4105CI3 gtp-binding protein typa bwei_0999 ENOG4105QA2 bwei_1003 ENOG4108IAB Phoh family bwei_1005 ENOG4105ZPI UPF0358 protein bwei_1006 ENOG4105CNI cell division protein FtsW bwei_1008 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) bwei_1017 ENOG4106UY4 Inherit from COG: Scp-like extracellular bwei_1020 ENOG4107TB6 phosphoglycerate mutase bwei_1022 ENOG4105WUC UPF0298 protein bwei_1024 ENOG4106H78 methyltransferase bwei_1025 ENOG4105H20 Sporulation integral membrane protein YlbJ bwei_1026 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) bwei_1027 ENOG4105D78 K07001 NTE family protein bwei_1028 ENOG41063PX domain protein bwei_1030 ENOG4105KNH Nucleic acid-binding protein bwei_1035 ENOG41074B2 UPF0747 protein bwei_1036 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) bwei_1038 ENOG4105CJN penicillin-binding protein bwei_1039 ENOG4105CJN penicillin-binding protein bwei_1040 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) bwei_1041 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) bwei_1042 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) bwei_1043 ENOG4105CNI cell division protein FtsW bwei_1044 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) bwei_1046 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) bwei_1047 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) bwei_1048 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) bwei_1050 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_1052 ENOG4105WR5 sporulation protein, YlmC YmxH family bwei_1053 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase bwei_1054 ENOG4105DFA alanine racemase domain protein bwei_1055 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) bwei_1056 ENOG41067XK integral membrane protein bwei_1057 ENOG4105DBK s4 domain protein bwei_1059 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) bwei_1062 ENOG4105C34 Pseudouridine synthase bwei_1063 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) bwei_1065 ENOG4105CXT aspartate transcarbamylase bwei_1066 ENOG4105CD3 dihydroorotase bwei_1068 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain bwei_1069 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) bwei_1070 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) bwei_1071 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) bwei_1072 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) bwei_1079 ENOG4105DC7 peptidase M24 bwei_1082 ENOG4105F23 Fibronectin-binding protein bwei_1084 ENOG4105DSJ YicC domain protein bwei_1088 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase bwei_1089 ENOG4105C25 Primosomal protein n' bwei_1090 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) bwei_1091 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) bwei_1092 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B bwei_1093 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs bwei_1094 ENOG4108ZF3 Phosphatase bwei_1095 ENOG4105D9P serine threonine protein kinase bwei_1097 ENOG4105DJV ribulose-phosphate 3-epimerase bwei_1098 ENOG4105FJ0 thiamine bwei_1100 ENOG4108ZAA Alkaline-shock protein bwei_1101 ENOG4105DP4 dak2 domain fusion protein ylov bwei_1102 ENOG4105CB5 ATP-dependent DNA helicase recG bwei_1104 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) bwei_1105 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase bwei_1106 ENOG4105CHR reductase bwei_1107 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) bwei_1108 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) bwei_1109 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) bwei_1110 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) bwei_1111 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) bwei_1114 ENOG4105VB6 UPF0109 protein bwei_1115 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) bwei_1116 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) bwei_1119 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) bwei_1120 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) bwei_1122 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha bwei_1123 ENOG4105C79 DNA protecting protein DprA bwei_1124 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) bwei_1125 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) bwei_1126 ENOG4108HE4 integrase family bwei_1127 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) bwei_1128 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) bwei_1130 ENOG4105CE9 30S ribosomal protein S2 bwei_1131 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) bwei_1133 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) bwei_1134 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) bwei_1135 ENOG4105KNE Phosphatidate cytidylyltransferase bwei_1137 ENOG4105DZP Membrane-associated zinc metalloprotease bwei_1138 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) bwei_1139 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) bwei_1140 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) bwei_1141 ENOG4105CHV Transcription elongation factor NusA bwei_1142 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination bwei_1143 ENOG4105VHM ribosomal protein bwei_1144 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) bwei_1145 ENOG4105W7A Protein of unknown function (DUF503) bwei_1148 ENOG4105DTN riboflavin biosynthesis protein ribF bwei_1150 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) bwei_1152 ENOG4105C1V Peptidase, M16 bwei_1155 ENOG4105E35 Dipicolinate synthase subunit A bwei_1156 ENOG4108S0H Dipicolinic acid synthetase, b subunit bwei_1157 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) bwei_1159 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) bwei_1161 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit bwei_1163 ENOG4107QZI cell division protein FtsK bwei_1165 ENOG4105FDP GntR family transcriptional regulator bwei_1166 ENOG4105DIH basic membrane bwei_1167 ENOG4108JQ9 ABC transporter bwei_1168 ENOG4105UIB (ABC) transporter bwei_1172 ENOG4108RKS Short-chain dehydrogenase reductase Sdr bwei_1173 ENOG4105XZV Protein of unknown function (DUF3243) bwei_1176 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase bwei_1177 ENOG4105CEV competence damage-inducible protein bwei_1179 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) bwei_1180 ENOG4105D48 metallophosphoesterase bwei_1181 ENOG4105MCT stage V sporulation protein S bwei_1182 ENOG4108IGT Dipeptidase bwei_1183 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein bwei_1184 ENOG4105DQU oxidoreductase, subunit beta bwei_1185 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) bwei_1188 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) bwei_1189 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) bwei_1191 ENOG4107QHE Choloylglycine hydrolase bwei_1193 ENOG410890F Dynamin family bwei_1194 ENOG4105E0M Sulfatase bwei_1196 ENOG4105F0V Cell wall hydrolase bwei_1198 ENOG4105CS2 ec 3.2.1.21 bwei_1199 ENOG4108S3Y transcriptional regulator bwei_1201 ENOG4107YEI lmbE family bwei_1202 ENOG4107TTQ Alpha beta hydrolase fold bwei_1205 ENOG41067MG lrgb family bwei_1213 ENOG4105BZU Histidine kinase bwei_1214 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_1219 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) bwei_1220 ENOG4105D03 DNA-3-methyladenine glycosylase II bwei_1221 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) bwei_1223 ENOG4105CGK Exodeoxyribonuclease III bwei_1227 ENOG4105E0A ABC, transporter bwei_1228 ENOG4105NIV Esterase bwei_1233 ENOG4105VPX protein, conserved in bacteria bwei_1234 ENOG410681U heavy metal transport detoxification protein bwei_1235 ENOG4105C59 p-type ATPase bwei_1237 ENOG4105K70 DNA-binding protein bwei_1238 ENOG4105TMB Formate nitrite transporter bwei_1242 ENOG4105C85 amino acid bwei_1245 ENOG4108SJC Membrane bwei_1246 ENOG4107QW4 alcohol dehydrogenase bwei_1247 ENOG4105E98 transcriptional regulator DeoR family bwei_1248 ENOG4105DE4 1-phosphofructokinase bwei_1249 ENOG4105DM4 PTS System bwei_1250 ENOG41069ER domain protein bwei_1252 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) bwei_1257 ENOG4106F1P AAA ATPase, central domain protein bwei_1259 ENOG4105EN6 Membrane bwei_1260 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) bwei_1261 ENOG4105CXI aluminum resistance protein bwei_1262 ENOG4105KV4 Transcriptional regulator bwei_1263 ENOG4105C5F glutamine synthetase bwei_1264 ENOG4105K7K Transcriptional regulator bwei_1267 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) bwei_1268 ENOG4108SVB resolvase bwei_1270 ENOG4105CGH 5'-nucleotidase bwei_1271 ENOG4108HW3 (ABC) transporter bwei_1278 ENOG4105BZ1 (ABC) transporter bwei_1279 ENOG4105BZ1 (ABC) transporter bwei_1283 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bwei_1288 ENOG41067MG lrgb family bwei_1290 ENOG4107RSM transcriptional regulator bwei_1292 ENOG4105CJ1 ABC, transporter bwei_1293 ENOG4108TU7 Inherit from COG: (ABC) transporter bwei_1294 ENOG4105CH2 amidohydrolase bwei_1296 ENOG4107QIV Cytochrome c biogenesis protein bwei_1302 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) bwei_1305 ENOG4105CGP Urocanate hydratase bwei_1307 ENOG4108903 Formimidoylglutamase bwei_1308 ENOG4108VJ1 Transcriptional regulator (CarD family bwei_1310 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase bwei_1311 ENOG4105CBC glutamate synthase bwei_1312 ENOG4105CK7 Sodium proline symporter bwei_1313 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase bwei_1314 ENOG4105FBA Phospholipase Carboxylesterase bwei_1316 ENOG4105BZU Histidine kinase bwei_1318 ENOG4107AYK membrAne bwei_1326 ENOG4108IMY Transcriptional regulator bwei_1327 ENOG4105CEY Amp-dependent synthetase and ligase bwei_1328 ENOG4107ZYJ bioY protein bwei_1329 ENOG4107F3J Amp-dependent synthetase and ligase bwei_1333 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) bwei_1335 ENOG4105E5W Transporter bwei_1341 ENOG4108I0Z Aconitate hydratase bwei_1342 ENOG4105BZ1 (ABC) transporter bwei_1345 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bwei_1346 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) bwei_1351 ENOG4105W8X HesB YadR YfhF-family protein bwei_1353 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase bwei_1354 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) bwei_1355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_1356 ENOG4105C0H protease bwei_1357 ENOG4105K4P CoA-binding domain protein bwei_1358 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) bwei_1360 ENOG4105D9R oxidoreductase bwei_1364 ENOG4105CIG ABC transporter bwei_1367 ENOG4108KGH TRANSCRIPTIONal bwei_1378 ENOG410696E Membrane bwei_1379 ENOG4105FR1 rard protein bwei_1382 ENOG4105EWU Squalene--hopene cyclase bwei_1384 ENOG4105CHR reductase bwei_1385 ENOG4105C26 Dehydrogenase bwei_1387 ENOG4108IA2 Sodium pantothenate symporter bwei_1390 ENOG4106IQC argininosuccinate lyase bwei_1392 ENOG410904N short-chain dehydrogenase reductase bwei_1396 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) bwei_1400 ENOG4105VEQ Cold shock protein bwei_1403 ENOG4108R1P bwei_1405 ENOG41073R8 VanW family bwei_1406 ENOG4108HW4 amino acid AbC transporter bwei_1408 ENOG4105EAB amino acid AbC transporter bwei_1409 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_1411 ENOG4105KT7 mgtC SapB transporter bwei_1418 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) bwei_1421 ENOG4105CQB FAD linked oxidase domain protein bwei_1428 ENOG4105CNG UPF0061 protein bwei_1429 ENOG4105CIS alcohol dehydrogenase bwei_1430 ENOG41082BM Transcriptional regulator, arsr family bwei_1438 ENOG4105EGI Transcriptional regulator bwei_1441 ENOG4108A04 Beta-lactamase bwei_1444 ENOG4105FFC UPF0187 protein bwei_1449 ENOG4105DPN Oligoendopeptidase f bwei_1450 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase bwei_1451 ENOG4105E5K Alpha-amylase bwei_1455 ENOG4105C98 muts2 protein bwei_1458 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein bwei_1459 ENOG4107V2S Transcriptional regulator bwei_1463 ENOG4105NX3 Membrane bwei_1467 ENOG4107R3E Citrate transporter bwei_1470 ENOG4108TN2 lmbE family bwei_1472 ENOG4105MWK D-amino acid dehydrogenase, small subunit bwei_1473 ENOG4105C26 Dehydrogenase bwei_1474 ENOG4105C3S Mate efflux family protein bwei_1477 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bwei_1482 ENOG4105CIS alcohol dehydrogenase bwei_1491 ENOG4105H3G oxidoreductase bwei_1493 ENOG4107R6D beta-lactam binding protein AmpH bwei_1497 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) bwei_1503 ENOG4105C44 Serine transporter bwei_1511 ENOG4105BZU Histidine kinase bwei_1518 ENOG4105NA0 Transcriptional regulator bwei_1528 ENOG4108VXD carboxy-peptidase bwei_1537 ENOG4105KVH Transcriptional regulator bwei_1538 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein bwei_1541 ENOG4105JAB phenazine biosynthesis protein, phzf family bwei_1550 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase bwei_1553 ENOG4105CMG Carbohydrate kinase bwei_1554 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) bwei_1555 ENOG4105DDN Pentapeptide repeat-containing protein bwei_1561 ENOG4105FAW cDP-glucose 4,6-dehydratase bwei_1562 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase bwei_1565 ENOG4105C37 (CBS) domain bwei_1571 ENOG4105EV4 Multidrug resistance protein mdtH bwei_1573 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) bwei_1577 ENOG4107BMA Transglycosylase associated protein bwei_1580 ENOG4105C31 Tryptophanyl-tRNA synthetase bwei_1581 ENOG4108UW5 maltose o-acetyltransferase bwei_1582 ENOG4106UW1 Major Facilitator superfamily bwei_1583 ENOG4105DKQ ROK family bwei_1584 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_1600 ENOG4108PSK reductase bwei_1603 ENOG4105KVH Transcriptional regulator bwei_1604 ENOG4108RCM Nitroreductase bwei_1605 ENOG4105G6Z alkaline phosphatase bwei_1611 ENOG4108Z66 YbaK ebsC protein bwei_1613 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) bwei_1614 ENOG4108K8S endonuclease I bwei_1620 ENOG4108JJB ABC transporter bwei_1628 ENOG4108X0B nad(p)h dehydrogenase (quinone) bwei_1630 ENOG4105CRW Short chain fatty acid transporter bwei_1632 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) bwei_1636 ENOG4107258 Transcriptional regulator bwei_1644 ENOG4108A04 Beta-lactamase bwei_1648 ENOG4105ED2 Beta-lactamase bwei_1655 ENOG4105IIU Aminopeptidase bwei_1695 ENOG4105W5Q DNA repair protein (RadC bwei_1724 ENOG4105D7V transposase bwei_1725 ENOG4105ETE Transcriptional regulator (LacI family bwei_1726 ENOG4105IE8 Alpha-ketoglutarate permease bwei_1728 ENOG4105CK5 oxidoreductase bwei_1733 ENOG4105D2N Aldolase bwei_1734 ENOG4105DH8 myo-inositol catabolism bwei_1741 ENOG4105DYB Isoaspartyl dipeptidase bwei_1745 ENOG4105VZ8 Transcriptional regulator bwei_1751 ENOG4105W1Y Transcriptional regulator bwei_1758 ENOG4105ZUU Transcriptional regulator bwei_1768 ENOG4105CZM Major Facilitator bwei_1769 ENOG4107MII Sugar-specific transcriptional regulator TrmB bwei_1772 ENOG4108ISG Major Facilitator bwei_1774 ENOG4105PNM synthesis protein bwei_1775 ENOG4108VXD carboxy-peptidase bwei_1786 ENOG4108IG5 Transcriptional regulator bwei_1793 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) bwei_1794 ENOG4108JQ1 Dehydrogenase bwei_1798 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A bwei_1801 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) bwei_1804 ENOG4105BZU Histidine kinase bwei_1809 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) bwei_1813 ENOG4105JQZ Methyltransferase bwei_1817 ENOG4105E0Y RtcB Protein bwei_1825 ENOG4105K6H D-cysteine desulfhydrase bwei_1832 ENOG41062D9 Histidine kinase bwei_1833 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_1840 ENOG4105C0R drug resistance transporter emrb qaca subfamily bwei_1841 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) bwei_1842 ENOG4105DMQ Methyltransferase bwei_1849 ENOG4108YXU transcriptional regulator AsnC family bwei_1850 ENOG4105CHR reductase bwei_1851 ENOG4108IG5 Transcriptional regulator bwei_1852 ENOG4107P5I polyketide synthase bwei_1855 ENOG41085FC arsR family transcriptional regulator bwei_1856 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_1857 ENOG4105D6J arsenicaL-resistance protein bwei_1861 ENOG4107ZQN disulfide bond bwei_1862 ENOG4108KF3 Electron transport protein SCO1 SenC bwei_1866 ENOG4105DIK (ABC) transporter bwei_1867 ENOG4105CC5 ABC transporter bwei_1868 ENOG4105DSE periplasmic solute binding protein bwei_1872 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase bwei_1874 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_1875 ENOG4105BZU Histidine kinase bwei_1877 ENOG4107VMI polysaccharide deacetylase bwei_1880 ENOG4105F6J Alpha beta hydrolase fold bwei_1887 ENOG4105CJ1 ABC, transporter bwei_1892 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) bwei_1895 ENOG4105FQP Beta-lactamase bwei_1898 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) bwei_1900 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) bwei_1906 ENOG4105DWD nucleoside recognition domain protein bwei_1908 ENOG41082BM Transcriptional regulator, arsr family bwei_1913 ENOG4105FDT acyl-CoA dehydrogenase bwei_1915 ENOG4106N3A copper homeostasis protein cutc bwei_1919 ENOG4107258 Transcriptional regulator bwei_1920 ENOG4105P4J Allophanate hydrolase, subunit 1 bwei_1922 ENOG4105E7W lamb ycsf family protein bwei_1925 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) bwei_1926 ENOG4105DUX Transporter bwei_1927 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) bwei_1928 ENOG4107RF6 penicillin-binding protein bwei_1934 ENOG4105F1N DNA alkylation repair bwei_1937 ENOG4108IQI permease bwei_1939 ENOG410635A Membrane bwei_1944 ENOG4105RHY Pfam:UPF0157 bwei_1950 ENOG4105BZU Histidine kinase bwei_1954 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_1974 ENOG4107XJU UPF0178 protein bwei_1976 ENOG4108PCN EamA-like transporter family bwei_1979 ENOG4108XET gCN5-related N-acetyltransferase bwei_1988 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family bwei_1992 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) bwei_1995 ENOG4105FS7 Transcriptional regulator bwei_1996 ENOG4108TVJ Nitroreductase bwei_1998 ENOG4105C7R Atpase associated with various cellular activities aaa_3 bwei_2006 ENOG4105CH6 catalase bwei_2007 ENOG4105C8Y Acetylornithine aminotransferase bwei_2011 ENOG4105C7R Atpase associated with various cellular activities aaa_3 bwei_2016 ENOG41068WN bwei_2025 ENOG4105VMP Transcriptional regulator bwei_2028 ENOG4105ECK Fatty Acid Desaturase bwei_2029 ENOG4105II7 pyrroline-5-carboxylate reductase bwei_2031 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) bwei_2032 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) bwei_2035 ENOG41075H3 AraC family transcriptional regulator bwei_2036 ENOG4107QK4 glycoside hydrolase, family 3 domain protein bwei_2040 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) bwei_2041 ENOG4108ZI4 Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_2044 ENOG4108I0C methyltransferase bwei_2045 ENOG41061GT Aldolase bwei_2048 ENOG4105DKT Transcriptional regulator bwei_2049 ENOG4105C2J ABC transporter bwei_2050 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane bwei_2052 ENOG4105D4B ABC, transporter bwei_2053 ENOG4105DWT malate dehydrogenase (quinone) bwei_2055 ENOG4108JUB Transcriptional regulator bwei_2057 ENOG4105E39 Enoyl-CoA hydratase bwei_2058 ENOG4105CY2 Citrate transporter bwei_2060 ENOG4108YYH Nadph-dependent fmn reductase bwei_2062 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase bwei_2064 ENOG41069ER domain protein bwei_2073 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase bwei_2074 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase bwei_2080 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) bwei_2081 ENOG41082JN Transcriptional regulator bwei_2082 ENOG4105EYF MMPL domain protein bwei_2089 ENOG4105C5H ABC transporter bwei_2093 ENOG4105C0R drug resistance transporter emrb qaca subfamily bwei_2096 ENOG4107VMI polysaccharide deacetylase bwei_2105 ENOG4108AQF aminoglycoside N(3)-acetyltransferase bwei_2111 ENOG4105C02 permease bwei_2119 ENOG4105FDP GntR family transcriptional regulator bwei_2120 ENOG4105DVE abc transporter atp-binding protein bwei_2126 ENOG4105CHM Aminotransferase bwei_2133 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) bwei_2136 ENOG4107BMA Transglycosylase associated protein bwei_2140 ENOG4106K7D Major facilitator family transporter bwei_2141 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) bwei_2150 ENOG4105CHJ isochorismatase hydrolase bwei_2156 ENOG4105EPR degv family bwei_2159 ENOG4105DPN Oligoendopeptidase f bwei_2160 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) bwei_2161 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 bwei_2165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_2167 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) bwei_2176 ENOG4105CPC Aldo Keto reductase bwei_2180 ENOG4105DTQ mandelate racemase muconate lactonizing bwei_2183 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD bwei_2186 ENOG4107T5V SNARE associated Golgi bwei_2192 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein bwei_2194 ENOG41080HI glycine oxidase bwei_2195 ENOG4105CTU Proline racemase bwei_2196 ENOG4105CTU Proline racemase bwei_2197 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) bwei_2198 ENOG4105C26 Dehydrogenase bwei_2199 ENOG4105BZG amino acid carrier protein bwei_2201 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) bwei_2205 ENOG4108M1A Chitin-binding protein bwei_2206 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase bwei_2214 ENOG4105C9U ATP-dependent DNA helicase RecQ bwei_2218 ENOG4105EEM helicase bwei_2222 ENOG4108Z7F N-acetyltransferase bwei_2228 ENOG4105MSB protein, conserved in bacteria bwei_2232 ENOG41087PP glycosyltransferase MGT family bwei_2234 ENOG4108M1A Chitin-binding protein bwei_2238 ENOG41082BV acetyltransferase bwei_2244 ENOG4108IJ7 Glycine betaine bwei_2245 ENOG4107SQ8 Glycine betaine bwei_2252 ENOG4105RHY Pfam:UPF0157 bwei_2253 ENOG4105E1F short-chain dehydrogenase reductase bwei_2255 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) bwei_2259 ENOG41062ES Transcriptional regulator bwei_2263 ENOG4105E98 transcriptional regulator DeoR family bwei_2269 ENOG4107Z3H Transcriptional regulator, TetR family bwei_2270 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) bwei_2271 ENOG4106IPI cyclase, family bwei_2272 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) bwei_2277 ENOG4105MSI germination protein ypeb bwei_2286 ENOG4105CIS alcohol dehydrogenase bwei_2292 ENOG4106NZI LysR family Transcriptional regulator bwei_2293 ENOG4105CPC Aldo Keto reductase bwei_2303 ENOG4105D6E homoserine dehydrogenase bwei_2306 ENOG4105ETU transcriptional activator (TenA bwei_2325 ENOG410667J hydrolase bwei_2327 ENOG4105BZU Histidine kinase bwei_2328 ENOG4107RF6 penicillin-binding protein bwei_2329 ENOG4105C3F Signal peptidase i bwei_2332 ENOG4108V7D UPF0397 protein bwei_2333 ENOG4108JJB ABC transporter bwei_2336 ENOG4108HGU Histidine kinase bwei_2340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_2341 ENOG4105GR3 Histidine kinase bwei_2342 ENOG4105CB2 alcohol dehydrogenase bwei_2343 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase bwei_2344 ENOG4105CJN penicillin-binding protein bwei_2350 ENOG4107Y80 Major Facilitator superfamily bwei_2352 ENOG4105KVH Transcriptional regulator bwei_2355 ENOG4107VXM glycerophosphoryl diester phosphodiesterase bwei_2360 ENOG4107Y9U Membrane bwei_2368 ENOG4105FCD Major Facilitator bwei_2369 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) bwei_2370 ENOG4108Z4K mutator MutT protein bwei_2377 ENOG4108XI2 Domain of unknown function (DUF1963) bwei_2382 ENOG4108NRW Phospholipase, patatin family bwei_2383 ENOG4105KWG Pfam:DUF1696 bwei_2391 ENOG4105PKS Excinuclease abc c subunit domain protein bwei_2395 ENOG4107RA9 decarboxylase bwei_2396 ENOG4105BZ1 (ABC) transporter bwei_2400 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase bwei_2402 ENOG4107VFR oxidoreductase bwei_2407 ENOG4105U0R haloacid dehalogenase-like hydrolase bwei_2410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_2411 ENOG4105BZU Histidine kinase bwei_2416 ENOG4107WD8 ABC transporter, permease bwei_2420 ENOG4105DY8 decarboxylase bwei_2423 ENOG4108IUM Glycogen debranching enzyme bwei_2425 ENOG4105CGH 5'-nucleotidase bwei_2427 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) bwei_2428 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) bwei_2430 ENOG4105FDR Membrane bwei_2431 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bwei_2434 ENOG410900G Protein of unknown function (DUF421) bwei_2438 ENOG4105CHR reductase bwei_2441 ENOG4105SX7 Transporter bwei_2448 ENOG4105KVH Transcriptional regulator bwei_2449 ENOG4105CHR reductase bwei_2454 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) bwei_2459 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) bwei_2464 ENOG4105DZ1 carboxypeptidase bwei_2474 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) bwei_2475 ENOG4107QX3 carboxylase bwei_2476 ENOG4105E39 Enoyl-CoA hydratase bwei_2477 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase bwei_2478 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit bwei_2479 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase bwei_2480 ENOG4105C1G acyl-Coa dehydrogenase bwei_2482 ENOG4107Z3H Transcriptional regulator, TetR family bwei_2484 ENOG4105CJ1 ABC, transporter bwei_2486 ENOG4107RGJ metallophosphoesterase bwei_2488 ENOG4108NQ3 Phosphatidylinositol-specific phospholipase C bwei_2489 ENOG4108M1A Chitin-binding protein bwei_2495 ENOG4105E1K spore germination protein bwei_2498 ENOG4107TPS domain protein bwei_2499 ENOG4105CEP NADH dehydrogenase bwei_2508 ENOG4107RF6 penicillin-binding protein bwei_2509 ENOG4107RF6 penicillin-binding protein bwei_2511 ENOG4105EMN RNA polymerase sigma factor bwei_2517 ENOG4107RVG penicillin-binding protein bwei_2530 ENOG4105C19 ABC transporter bwei_2533 ENOG4105EQK -acetyltransferase bwei_2538 ENOG4105CIN aminoacyl-histidine dipeptidase bwei_2543 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) bwei_2545 ENOG4108V4B ThiJ pfpI bwei_2547 ENOG41088CC tellurite resistance protein tehB bwei_2548 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) bwei_2551 ENOG4108RZE Tetr family transcriptional regulator bwei_2552 ENOG4105C1J atp-dependent rna helicase bwei_2564 ENOG4107STF Involved in phosphonate degradation (By similarity) bwei_2566 ENOG4105RD7 BadF BadG BcrA BcrD bwei_2567 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) bwei_2571 ENOG4105F32 YngK protein bwei_2576 ENOG4108KPJ rna polymerase sigma factor bwei_2577 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B bwei_2579 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) bwei_2586 ENOG4108JCI Transcriptional regulator bwei_2587 ENOG4108VP3 Lysine exporter protein (LysE YggA) bwei_2594 ENOG4105BZ1 (ABC) transporter bwei_2595 ENOG4105BZ1 (ABC) transporter bwei_2598 ENOG4108RPX mosc domain containing protein bwei_2599 ENOG4108JPW Aminotransferase bwei_2600 ENOG4105DND Transcriptional regulator bwei_2603 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) bwei_2604 ENOG4107V2S Transcriptional regulator bwei_2610 ENOG41068WN bwei_2612 ENOG4105C1Q protoporphyrinogen oxidase bwei_2618 ENOG4105WCN acetyltransferase bwei_2620 ENOG4108NHD germination protein bwei_2621 ENOG4108Q8B Spore germination protein bwei_2624 ENOG4105EYF MMPL domain protein bwei_2625 ENOG41067SE Tetr family transcriptional regulator bwei_2628 ENOG4107MII Sugar-specific transcriptional regulator TrmB bwei_2632 ENOG4108Y4K DNA-binding transcriptional activator bwei_2634 ENOG41081I9 integral membrane protein bwei_2637 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) bwei_2638 ENOG4105C37 (CBS) domain bwei_2639 ENOG4108D32 Methyltransferase bwei_2644 ENOG4107SKW Inherit from COG: Alpha beta hydrolase bwei_2646 ENOG4105C19 ABC transporter bwei_2648 ENOG4105VMP Transcriptional regulator bwei_2649 ENOG4105C22 threonyL-tRNA synthetase bwei_2650 ENOG4105FE9 pseudouridine synthase bwei_2655 ENOG4105BZG amino acid carrier protein bwei_2658 ENOG4105K70 DNA-binding protein bwei_2661 ENOG4105C0R drug resistance transporter emrb qaca subfamily bwei_2662 ENOG4105WQT MbtH domain protein bwei_2663 ENOG4105CEY Amp-dependent synthetase and ligase bwei_2664 ENOG4105WQI isochorismatase bwei_2665 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase bwei_2666 ENOG4105E4F Isochorismate synthase bwei_2667 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase bwei_2668 ENOG4105FCD Major Facilitator bwei_2674 ENOG4105EYH Exonuclease bwei_2675 ENOG4107RFY SbcCD D subunit bwei_2678 ENOG4105E39 Enoyl-CoA hydratase bwei_2679 ENOG4105N14 lysine exporter protein LysE YggA bwei_2681 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase bwei_2682 ENOG4105C1G acyl-Coa dehydrogenase bwei_2683 ENOG4105CR4 methylisocitrate lyase bwei_2684 ENOG4105DXD 2-methylcitrate dehydratase bwei_2686 ENOG4105CZM Major Facilitator bwei_2687 ENOG4105BZ4 penicillin-binding protein bwei_2691 ENOG4105CHR reductase bwei_2696 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) bwei_2714 ENOG4105SZ6 Thioredoxin bwei_2715 ENOG410841Q phosphoesterase PA-phosphatase related protein bwei_2740 ENOG4107Y5K Resolvase bwei_2744 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein bwei_2746 ENOG4108JUB Transcriptional regulator bwei_2747 ENOG4108TSC N-acetyltransferase bwei_2748 ENOG4107S4Y M20 DapE family protein YgeY bwei_2751 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bwei_2756 ENOG4105C37 (CBS) domain bwei_2765 ENOG4105E90 ABC transporter bwei_2766 ENOG4108IJ8 ABC transporter bwei_2771 ENOG4105C6Z Gluconate bwei_2772 ENOG4105CMG Carbohydrate kinase bwei_2777 ENOG4106KNT transcriptional regulator bwei_2778 ENOG4105WH1 Two component transcriptional regulator luxr family bwei_2779 ENOG4105BZU Histidine kinase bwei_2780 ENOG4105D8X mechanosensitive ion channel bwei_2785 ENOG4105F0I Aminotransferase bwei_2786 ENOG4108MES Periplasmic binding protein bwei_2787 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase bwei_2789 ENOG4105CAQ asparagine synthetase bwei_2790 ENOG4107Y70 Heat shock protein bwei_2791 ENOG4108KF3 Electron transport protein SCO1 SenC bwei_2792 ENOG4105E8R UPF0173 metal-dependent hydrolase bwei_2793 ENOG4108RCR degv family bwei_2795 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) bwei_2797 ENOG4108UT2 hemolysin iii bwei_2798 ENOG4105E9Q Acyl-transferase bwei_2800 ENOG4107RVG penicillin-binding protein bwei_2808 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 bwei_2812 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase bwei_2813 ENOG4105KD7 acetyltransferase bwei_2817 ENOG4105CY2 Citrate transporter bwei_2819 ENOG4107XGZ Hydrolase bwei_2824 ENOG4105C8J )-transporter bwei_2834 ENOG4105EC2 ftsk spoIIIe bwei_2838 ENOG4105C5S asparaginyl-tRNA synthetase bwei_2840 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) bwei_2845 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) bwei_2849 ENOG4105C75 arginyL-tRNA synthetase bwei_2850 ENOG4107YX5 Pfam:DUF548 bwei_2854 ENOG4108UUM single-stranded DNA-binding protein bwei_2857 ENOG4105C5H ABC transporter bwei_2876 ENOG4107T65 Integrase bwei_2877 ENOG4105MCT stage V sporulation protein S bwei_2885 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) bwei_2886 ENOG4108IFG nitrite reductase, (NAD(P)H) bwei_2887 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit bwei_2888 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) bwei_2889 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein bwei_2890 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein bwei_2893 ENOG4105GAK amidohydrolase 2 bwei_2897 ENOG4108ZAF Molybdopterin bwei_2898 ENOG4105CVM Molybdenum cofactor synthesis domain protein bwei_2899 ENOG4105D06 uba thif-type nad fad binding protein bwei_2900 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) bwei_2901 ENOG4107V6Q Cyclic nucleotide-binding domain bwei_2903 ENOG4105R3A Nitrate reductase bwei_2904 ENOG4108IUE nitrate reductase beta subunit bwei_2908 ENOG4105C7R Atpase associated with various cellular activities aaa_3 bwei_2912 ENOG4108V06 Glutathione peroxidase bwei_2914 ENOG4105CNW domain protein bwei_2918 ENOG4105EMN RNA polymerase sigma factor bwei_2920 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein bwei_2922 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily bwei_2923 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) bwei_2927 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) bwei_2932 ENOG4105KBJ sporulation protein ytfj bwei_2936 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) bwei_2941 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bwei_2942 ENOG4108JYZ YitT family bwei_2943 ENOG41087PP glycosyltransferase MGT family bwei_2946 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bwei_2947 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) bwei_2949 ENOG4108X4Q Hydrolase bwei_2951 ENOG4108ZRV stage ii sporulation protein p bwei_2956 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) bwei_2957 ENOG4108VXD carboxy-peptidase bwei_2959 ENOG4108ZRV stage ii sporulation protein p bwei_2962 ENOG4108Z7R Chaperone CsaA bwei_2966 ENOG4105C37 (CBS) domain bwei_2967 ENOG4105SXS Protein of unknown function (DUF456) bwei_2973 ENOG4108S4H thioesterase Superfamily protein bwei_2975 ENOG4108PJD permease bwei_2978 ENOG4107T5V SNARE associated Golgi bwei_2982 ENOG4107TB6 phosphoglycerate mutase bwei_2987 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) bwei_2988 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase bwei_2991 ENOG4105DSE periplasmic solute binding protein bwei_2995 ENOG4105CKI cobalamin synthesis protein bwei_2996 ENOG4107QM2 Aldo Keto reductase bwei_2997 ENOG4105VMI -acetyltransferase bwei_3000 ENOG4105DEN Luciferase family bwei_3003 ENOG4108WPJ Ferritin-like domain bwei_3004 ENOG4108K88 Membrane bwei_3007 ENOG4105C8Q Methyl-accepting chemotaxis bwei_3013 ENOG4105CPC Aldo Keto reductase bwei_3014 ENOG4105YVS arsR family transcriptional regulator bwei_3016 ENOG4105KRN Transcriptional regulator, abrb family bwei_3026 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bwei_3027 ENOG4108ZUB Lysine exporter protein (Lyse ygga) bwei_3029 ENOG4105YWU small acid-soluble spore protein bwei_3030 ENOG4108WBH protein TIM barrel bwei_3033 ENOG4105CEY Amp-dependent synthetase and ligase bwei_3034 ENOG4105DUU IucA IucC family protein bwei_3036 ENOG4105VRR gCN5-related N-acetyltransferase bwei_3037 ENOG4105KT7 mgtC SapB transporter bwei_3038 ENOG4105D7V transposase bwei_3040 ENOG4107VMI polysaccharide deacetylase bwei_3041 ENOG4105BZU Histidine kinase bwei_3042 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bwei_3044 ENOG4108KGH TRANSCRIPTIONal bwei_3047 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) bwei_3049 ENOG4105D6E homoserine dehydrogenase bwei_3054 ENOG41075D4 Aminoglycoside 6-adenylyltransferase bwei_3055 ENOG4108VQJ O-methyltransferase bwei_3057 ENOG4105BZU Histidine kinase bwei_3058 ENOG4105EFI regulatoR bwei_3059 ENOG4105BZ1 (ABC) transporter bwei_3070 ENOG4108JJ8 (ABC) transporter bwei_3071 ENOG4108JJ9 ABC, transporter bwei_3072 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii bwei_3073 ENOG4105C4M (Ubiquinol oxidase) subunit I bwei_3078 ENOG4105MDS 4-oxalocrotonate tautomerase bwei_3080 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family bwei_3082 ENOG4105C32 Amino acid ABC transporter (Permease) bwei_3083 ENOG4108IV0 ABC, transporter bwei_3084 ENOG4105C0Z ABC transporter bwei_3086 ENOG4105CKI cobalamin synthesis protein bwei_3088 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) bwei_3090 ENOG4106F5Q Membrane bwei_3091 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) bwei_3094 ENOG4108TVJ Nitroreductase bwei_3095 ENOG4107ZXU DSBA oxidoreductase bwei_3096 ENOG4108Z40 Transcriptional regulator bwei_3097 ENOG4105GZI Transcriptional regulator bwei_3098 ENOG4107RT3 EamA-like transporter family bwei_3100 ENOG4105KTB nuclear export factor GLE1 bwei_3101 ENOG4108T5E Copper resistance protein bwei_3104 ENOG4105ED2 Beta-lactamase bwei_3110 ENOG4105FQP Beta-lactamase bwei_3112 ENOG4107TUM Amidinotransferase bwei_3118 ENOG4105C5Q Transcriptional regulator bwei_3123 ENOG4107R16 Multicopper oxidase bwei_3124 ENOG4107RAQ aminopeptidase bwei_3133 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) bwei_3134 ENOG4105D9N nucleoside bwei_3135 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) bwei_3137 ENOG4107RHR regulatoR bwei_3138 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid bwei_3140 ENOG4105KNA -acetyltransferase bwei_3141 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) bwei_3143 ENOG410829K Lysine exporter protein (Lyse ygga) bwei_3147 ENOG4105C0X amino acid bwei_3149 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) bwei_3151 ENOG4105C72 UPF0176 protein bwei_3152 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) bwei_3156 ENOG41068WN bwei_3170 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b bwei_3171 ENOG4105C6X Major Facilitator bwei_3175 ENOG4105C7B Threonine dehydratase bwei_3176 ENOG4105C01 Dihydroxy-acid dehydratase bwei_3177 ENOG4105CHR reductase bwei_3178 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_3179 ENOG4105BZU Histidine kinase bwei_3181 ENOG4105E3B Multicopper oxidase bwei_3182 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) bwei_3187 ENOG4105H67 Protein of unknown function (DUF421) bwei_3188 ENOG4105X5K response regulator receiver protein bwei_3190 ENOG4105C8J )-transporter bwei_3194 ENOG4105C6T cysteine synthase bwei_3195 ENOG4105EU0 Major facilitator Superfamily bwei_3196 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) bwei_3199 ENOG4105DXI Major Facilitator superfamily bwei_3202 ENOG4105CSR polyphosphate kinase 2 bwei_3210 ENOG4105FVX bwei_3217 ENOG4105CU9 asparagine synthetase A bwei_3223 ENOG4105C6K Malic enzyme bwei_3224 ENOG4108IJ0 Aspartate ammonia-lyase bwei_3227 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) bwei_3231 ENOG4105CJ1 ABC, transporter bwei_3239 ENOG4106BRA Membrane bwei_3240 ENOG4105BZC d-serine deaminase bwei_3243 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bwei_3244 ENOG4107QIV Cytochrome c biogenesis protein bwei_3248 ENOG4105EC3 peptidase S51, dipeptidase E bwei_3249 ENOG4107QJQ Mate efflux family protein bwei_3253 ENOG4105DNP FAD linked oxidase domain protein bwei_3254 ENOG4105C9Q fumarate hydratase class II bwei_3255 ENOG4105DFD Na H antiporter bwei_3259 ENOG4108UZ3 Transporter bwei_3260 ENOG4105DRR Transcriptional regulator, GntR family bwei_3262 ENOG4105PGM cation diffusion facilitator family transporter bwei_3266 ENOG4105CAQ asparagine synthetase bwei_3272 ENOG4105CVJ phosphoglycerate mutase bwei_3280 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component bwei_3282 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) bwei_3283 ENOG4105DUM transcriptional regulator, lysR family bwei_3288 ENOG4108U4N (sortase) family bwei_3292 ENOG4105KAC Antibiotic biosynthesis monooxygenase bwei_3298 ENOG4105CPU Monooxygenase bwei_3299 ENOG4105CGA flagellar basal-body rod protein FlgG bwei_3300 ENOG4105FZW flagellar biosynthesis regulator FlhF bwei_3301 ENOG4105D7B Flagellar biosynthesis protein flha bwei_3302 ENOG4105D00 flagellar biosynthetic protein flhB bwei_3304 ENOG4105VS8 Flagellar biosynthetic protein fliq bwei_3305 ENOG4105CN7 Flagellar biosynthetic protein FliP bwei_3307 ENOG4105DD5 Flagellar motor switch protein bwei_3308 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) bwei_3310 ENOG4105E4C Lytic transglycosylase catalytic bwei_3311 ENOG4105I03 Flagellin bwei_3314 ENOG4105D1F ATP-binding protein bwei_3315 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) bwei_3316 ENOG41067WU Molybdopterin converting factor (Subunit 1) bwei_3317 ENOG4108ZAF Molybdopterin bwei_3318 ENOG4105CVM Molybdenum cofactor synthesis domain protein bwei_3319 ENOG4105D06 uba thif-type nad fad binding protein bwei_3320 ENOG4105TMB Formate nitrite transporter bwei_3322 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) bwei_3323 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) bwei_3325 ENOG4108JB9 formate dehydrogenase bwei_3326 ENOG4107TS3 membrane protein, TerC bwei_3327 ENOG4105BZU Histidine kinase bwei_3330 ENOG4107R88 Chemotaxis protein (CheV) bwei_3333 ENOG4105BZE flagellar hook protein, FlgE bwei_3339 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) bwei_3340 ENOG4107U2N Flagellar M-ring protein bwei_3341 ENOG41075Z6 flagellar hook-basal body complex protein fliE bwei_3342 ENOG4108ZC9 flagellar basal-body rod protein flgc bwei_3343 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) bwei_3348 ENOG4105DTJ flagellar hook-associated protein bwei_3349 ENOG4105E1Q flagellar hook-associated protein bwei_3353 ENOG4105BZU Histidine kinase bwei_3356 ENOG4105DD5 Flagellar motor switch protein bwei_3357 ENOG4105CBS Chea signal transduction histidine kinase bwei_3358 ENOG4107YTP response regulator receiver protein bwei_3359 ENOG4105ER2 Ompa motb domain protein bwei_3360 ENOG4107R0U MotA TolQ exbB proton channel bwei_3362 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) bwei_3370 ENOG4105DQ6 Transposase bwei_3373 ENOG41080C8 DUF218 domain bwei_3375 ENOG4105H67 Protein of unknown function (DUF421) bwei_3377 ENOG4108Z5V transcriptional regulator, merr family bwei_3378 ENOG4107RWR Sodium hydrogen exchanger bwei_3380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) bwei_3393 ENOG41081VK Ribonuclease bwei_3397 ENOG4108SZE gCN5-related N-acetyltransferase bwei_3401 ENOG4105CPK Glycosyl transferase (Group 1 bwei_3416 ENOG4105KHC sulfurtransferase bwei_3418 ENOG4108W0I acetyltransferase bwei_3420 ENOG410890F Dynamin family bwei_3422 ENOG4105DHF Membrane bwei_3423 ENOG4105C2W permease bwei_3424 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) bwei_3426 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) bwei_3428 ENOG4105CTD carboxy-peptidase bwei_3429 ENOG4105DVT helicase bwei_3431 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) bwei_3432 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) bwei_3433 ENOG4108UKS UPF0398 protein bwei_3441 ENOG4105BZ4 penicillin-binding protein bwei_3443 ENOG4105CSM endonuclease III bwei_3447 ENOG4105YAC bwei_3448 ENOG4105DVT helicase bwei_3450 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) bwei_3451 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) bwei_3453 ENOG4105DJ0 Poly(A) Polymerase bwei_3454 ENOG4105CPK Glycosyl transferase (Group 1 bwei_3455 ENOG4105FJR Lmbe family bwei_3456 ENOG4108Z5K methylglyoxal synthase bwei_3457 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) bwei_3458 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase bwei_3459 ENOG4108JYZ YitT family bwei_3466 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit bwei_3467 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) bwei_3468 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) bwei_3471 ENOG41068YB TPR repeat-containing protein bwei_3472 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase bwei_3475 ENOG4105D49 3-dehydroquinate synthase bwei_3476 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase bwei_3477 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) bwei_3478 ENOG4105EAH synthase bwei_3479 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) bwei_3480 ENOG4105XXQ heptaprenyl diphosphate synthase component I bwei_3483 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) bwei_3487 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase bwei_3488 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) bwei_3489 ENOG41065D1 bwei_3490 ENOG4105S2F bwei_3494 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) bwei_3496 ENOG4105CAT Cytidine monophosphate kinase bwei_3498 ENOG4107RB3 L-asparaginase bwei_3499 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase bwei_3504 ENOG4108S6Z Negative regulator of genetic competence bwei_3505 ENOG4107X2D transcriptional regulator, merr family bwei_3506 ENOG4107RGJ metallophosphoesterase bwei_3508 ENOG4105I7S Abortive infection protein bwei_3509 ENOG4105C9U ATP-dependent DNA helicase RecQ bwei_3510 ENOG4105T7X bwei_3512 ENOG4108SAX Membrane bwei_3514 ENOG41063SB peptidase bwei_3515 ENOG4108WBT adenosyltransferase bwei_3516 ENOG4105BZU Histidine kinase bwei_3517 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_3518 ENOG4105CRE cytochrome C bwei_3519 ENOG4107TWT Cytochrome c biogenesis protein bwei_3521 ENOG4105FE9 pseudouridine synthase bwei_3523 ENOG4108JIC nucleoside recognition domain protein bwei_3524 ENOG4105DZ1 carboxypeptidase bwei_3525 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) bwei_3531 ENOG4105BZU Histidine kinase bwei_3536 ENOG4105I3N Conserved Protein bwei_3537 ENOG4105BZU Histidine kinase bwei_3542 ENOG4105BZ4 penicillin-binding protein bwei_3543 ENOG4107GRR phosphate transport regulator bwei_3544 ENOG4105CJ3 phosphate transporter bwei_3554 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) bwei_3557 ENOG4105WH1 Two component transcriptional regulator luxr family bwei_3558 ENOG4105ENE Histidine kinase bwei_3563 ENOG4105DFD Na H antiporter bwei_3568 ENOG4105C8J )-transporter bwei_3569 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein bwei_3570 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein bwei_3571 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) bwei_3573 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) bwei_3574 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) bwei_3575 ENOG4107RIQ Sulfate adenylate transferase bwei_3576 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) bwei_3578 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) bwei_3580 ENOG4105E0M Sulfatase bwei_3581 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase bwei_3584 ENOG4107RVV histidinol phosphate phosphatase, hisj family bwei_3585 ENOG4105KPZ phosphoribosyl-atp pyrophosphatase bwei_3587 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) bwei_3588 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase bwei_3589 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) bwei_3590 ENOG4105ECC imidazole-glycerol-phosphate dehydratase bwei_3592 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) bwei_3593 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) bwei_3595 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) bwei_3597 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) bwei_3599 ENOG4108ZP8 Acetolactate synthase small subunit bwei_3600 ENOG4105C7K acetolactate synthase bwei_3601 ENOG4105CM2 brancheD-chain amino acid aminotransferase bwei_3606 ENOG4105KBJ sporulation protein ytfj bwei_3608 ENOG4105CZN Potassium uptake protein bwei_3615 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) bwei_3616 ENOG4107QMU Mate efflux family protein bwei_3623 ENOG4105NQC Flavodoxin bwei_3628 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein bwei_3629 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) bwei_3630 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD bwei_3631 ENOG4105EA8 2-Nitropropane dioxygenase bwei_3632 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A bwei_3640 ENOG4105CJ1 ABC, transporter bwei_3642 ENOG4105CZV ABC transporter bwei_3643 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family bwei_3644 ENOG4105C8Y Acetylornithine aminotransferase bwei_3645 ENOG4105C26 Dehydrogenase bwei_3647 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family bwei_3650 ENOG4105D82 Glutamate dehydrogenase bwei_3651 ENOG4105CUB amino acid bwei_3652 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) bwei_3653 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) bwei_3654 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) bwei_3655 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) bwei_3658 ENOG4108R6G acetyltransferase bwei_3662 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) bwei_3663 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) bwei_3664 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase bwei_3665 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) bwei_3666 ENOG4105BZU Histidine kinase bwei_3669 ENOG4106DF1 bwei_3671 ENOG41090MY MarR family Transcriptional regulator bwei_3673 ENOG4105BZU Histidine kinase bwei_3675 ENOG4105PXI polysaccharide deacetylase bwei_3677 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) bwei_3680 ENOG4105E98 transcriptional regulator DeoR family bwei_3682 ENOG4107QMX Aminotransferase bwei_3683 ENOG4108KAZ Involved in phosphonate degradation (By similarity) bwei_3684 ENOG4107RCV ABC transporter, permease bwei_3685 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) bwei_3686 ENOG4105C4Y ABC transporter bwei_3692 ENOG4105CHR reductase bwei_3696 ENOG4108Z7G MaoC domain protein dehydratase bwei_3697 ENOG410681C small acid-soluble spore protein bwei_3699 ENOG4105CZN Potassium uptake protein bwei_3700 ENOG4107TS3 membrane protein, TerC bwei_3701 ENOG4108QTI )-transporter bwei_3703 ENOG4106A3R peptidase bwei_3705 ENOG4107QR9 Iron-sulfur cluster binding protein bwei_3707 ENOG4105JXH GntR family transcriptional regulator bwei_3708 ENOG4105BZU Histidine kinase bwei_3709 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_3712 ENOG4105CQB FAD linked oxidase domain protein bwei_3713 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) bwei_3714 ENOG4105K4I Scp-like extracellular bwei_3716 ENOG4108YBP pseudouridine synthase bwei_3718 ENOG4105EYF MMPL domain protein bwei_3720 ENOG4107RUE extracellular solute-binding protein family 1 bwei_3721 ENOG4105D38 putrescine abc transporter bwei_3722 ENOG4105F38 ABC transporter, permease bwei_3724 ENOG4105C26 Dehydrogenase bwei_3731 ENOG4105VFR signal peptidase bwei_3732 ENOG4105DZ1 carboxypeptidase bwei_3741 ENOG4105VZ8 Transcriptional regulator bwei_3742 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 bwei_3743 ENOG4105C7S Dehydrogenase bwei_3747 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) bwei_3759 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) bwei_3760 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) bwei_3761 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase bwei_3763 ENOG4108I0Q anthranilate phosphoribosyltransferase bwei_3764 ENOG4105DDQ anthranilate synthase bwei_3765 ENOG4105CRQ synthase (Component I) bwei_3767 ENOG4105CK7 Sodium proline symporter bwei_3784 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase bwei_3786 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase bwei_3787 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) bwei_3791 ENOG4107TVC Glycosyl transferase, family 2 bwei_3796 ENOG4105K64 Glycosyl transferase, family 2 bwei_3800 ENOG4105EMS pseudouridine synthase bwei_3801 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) bwei_3804 ENOG4105MIX Adenylate cyclase bwei_3805 ENOG4108Z18 K06886 hemoglobin bwei_3808 ENOG4105DPN Oligoendopeptidase f bwei_3810 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) bwei_3812 ENOG4108ZCF integral membrane protein bwei_3816 ENOG4105UQX Mate efflux family protein bwei_3817 ENOG4108JQ7 (ABC) transporter bwei_3819 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bwei_3820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component bwei_3823 ENOG4105C31 Tryptophanyl-tRNA synthetase bwei_3826 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) bwei_3827 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) bwei_3834 ENOG4108KP7 hydrolase bwei_3837 ENOG4107AYK membrAne bwei_3839 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) bwei_3844 ENOG4108VJ1 Transcriptional regulator (CarD family bwei_3847 ENOG4105QNR S1 RNA binding domain protein bwei_3848 ENOG4108VPT UPF0234 protein bwei_3850 ENOG4105BZU Histidine kinase bwei_3851 ENOG4105CH6 catalase bwei_3853 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) bwei_3854 ENOG4105CAQ asparagine synthetase bwei_3856 ENOG4106BKT UPF0344 protein bwei_3859 ENOG4105ERH Fumarylacetoacetate hydrolase bwei_3869 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation bwei_3870 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination bwei_3873 ENOG4105XVF Competence transcription factor bwei_3879 ENOG4107QP3 malate synthase g bwei_3880 ENOG4105ZU5 s-layer protein bwei_3884 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 bwei_3888 ENOG4105DPZ Two component transcriptional regulator (Winged helix family bwei_3890 ENOG41086D8 Transcriptional regulator bwei_3891 ENOG4108AEY RNA polymerase sigma factor bwei_3894 ENOG4107TVP HD domain protein bwei_3895 ENOG4107RN3 metallophosphoesterase bwei_3902 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein bwei_3905 ENOG4105CEY Amp-dependent synthetase and ligase bwei_3907 ENOG4105DF9 Lipoate-protein, ligase bwei_3908 ENOG4108RQ5 Beta-lactamase domain-containing protein bwei_3909 ENOG4106AXD bwei_3917 ENOG4105ECB domain protein bwei_3917 ENOG4105ECB domain protein bwei_3924 ENOG4105C1Q protoporphyrinogen oxidase bwei_3926 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) bwei_3927 ENOG4105BZ4 penicillin-binding protein bwei_3928 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation bwei_3929 ENOG4105CKV Membrane bwei_3930 ENOG410905X membrane-flanked domain protein bwei_3939 ENOG4105CKV Membrane bwei_3940 ENOG410905X membrane-flanked domain protein bwei_3947 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) bwei_3949 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) bwei_3953 ENOG4105K59 histidine triad (HIT) protein bwei_3958 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) bwei_3959 ENOG4105EEM helicase bwei_3962 ENOG4105EMN RNA polymerase sigma factor bwei_3964 ENOG4105C6V Glycerol-3-phosphate dehydrogenase bwei_3965 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) bwei_3967 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator bwei_3968 ENOG41067QW Transcriptional regulator bwei_3971 ENOG4108MUZ hydrolase bwei_3973 ENOG4107JM4 Tetratricopeptide repeat bwei_3978 ENOG4105EQI Metal Dependent Phosphohydrolase bwei_3979 ENOG4106D4I domain protein bwei_3980 ENOG4107VRP DNA repair exonuclease bwei_3985 ENOG4108VB1 regulatoR bwei_3986 ENOG4105ENE Histidine kinase bwei_3991 ENOG4105C6F GntR Family Transcriptional Regulator bwei_3992 ENOG4105DJ2 Major Facilitator Superfamily bwei_3998 ENOG4105BZU Histidine kinase bwei_3999 ENOG4105BZU Histidine kinase bwei_4000 ENOG4108MJI response regulator bwei_4002 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_4004 ENOG4105WN5 stage II sporulation protein bwei_4026 ENOG4107RBI VanW family bwei_4031 ENOG4105FBW Monooxygenase bwei_4034 ENOG4105CMT Dihydroxyacetone kinase bwei_4036 ENOG4105CMT Dihydroxyacetone kinase bwei_4041 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase bwei_4043 ENOG4105CS2 ec 3.2.1.21 bwei_4044 ENOG4105C5Y PTS System bwei_4045 ENOG4105CID antiterminator bwei_4046 ENOG4105DQ6 Transposase bwei_4050 ENOG4105WAB arsR family transcriptional regulator bwei_4051 ENOG4105F27 Major Facilitator bwei_4054 ENOG41067XF inhibitor bwei_4069 ENOG4105C0R drug resistance transporter emrb qaca subfamily bwei_4074 ENOG4105CDU Replicative dna helicase bwei_4081 ENOG4107SCJ type I restriction enzyme EcoKI subunit R bwei_4086 ENOG4108MRH transcriptional regulatory protein bwei_4088 ENOG4105CSH Transporter bwei_4094 ENOG4108JQ7 (ABC) transporter bwei_4095 ENOG4105C3U ABC transporter bwei_4096 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bwei_4104 ENOG4105D5U fad dependent oxidoreductase bwei_4111 ENOG4105DER m42 family bwei_4114 ENOG4105CGU Enoyl-CoA hydratase bwei_4118 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein bwei_4120 ENOG4106AKK s-layer domain-containing protein bwei_4127 ENOG4105CHH sulfate transporter bwei_4131 ENOG4107ZTW SNARE associated Golgi bwei_4132 ENOG4105CEY Amp-dependent synthetase and ligase bwei_4133 ENOG4105D4P Coproporphyrinogen iii oxidase bwei_4134 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bwei_4136 ENOG4108VX5 3-methyladenine DNA glycosylase bwei_4137 ENOG4107R51 Glycosyl transferase, family 2 bwei_4138 ENOG4106WTF Glycosyl transferase, family 2 bwei_4139 ENOG4107FQX Alpha-acetolactate decarboxylase bwei_4143 ENOG4105WZB UPF0342 protein bwei_4144 ENOG4108UH6 UPF0754 membrane protein bwei_4146 ENOG410839P bwei_4149 ENOG4105CDA abc transporter atp-binding protein bwei_4150 ENOG4105DRP amino acid AbC transporter bwei_4152 ENOG4105BZ1 (ABC) transporter bwei_4153 ENOG4105BZ1 (ABC) transporter bwei_4155 ENOG4105C26 Dehydrogenase bwei_4156 ENOG4105D5Q Arginine ornithine antiporter bwei_4158 ENOG4107RKG DJ-1/PfpI family bwei_4161 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF bwei_4166 ENOG4105KPY Small multidrug resistance protein bwei_4167 ENOG4105KPY Small multidrug resistance protein bwei_4169 ENOG4108IXY short-chain dehydrogenase reductase bwei_4171 ENOG4108YXU transcriptional regulator AsnC family bwei_4172 ENOG4108PCN EamA-like transporter family bwei_4179 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate bwei_4180 ENOG4106KNT transcriptional regulator bwei_4182 ENOG4107RWR Sodium hydrogen exchanger bwei_4183 ENOG4105CUB amino acid bwei_4189 ENOG4107T5V SNARE associated Golgi bwei_4194 ENOG4105WEF catalase bwei_4201 ENOG4105C19 ABC transporter bwei_4202 ENOG4107RBB ABC transporter, permease bwei_4203 ENOG41069ER domain protein bwei_4207 ENOG4105VZJ PTS System bwei_4208 ENOG4105VCP PTS System bwei_4209 ENOG4105EMD TRANSCRIPTIONal bwei_4214 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein bwei_4217 ENOG4108KGH TRANSCRIPTIONal bwei_4219 ENOG41087NI Sulfite exporter TauE/SafE bwei_4220 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase bwei_4221 ENOG4105VFE sira family bwei_4222 ENOG4105VFE sira family bwei_4223 ENOG4107TPS domain protein bwei_4224 ENOG4105VFE sira family bwei_4225 ENOG4105XTG Pfam:DUF156 bwei_4231 ENOG4105ED1 spovr family bwei_4232 ENOG4107Y03 Nitroreductase bwei_4236 ENOG4108B31 Spore germination protein bwei_4240 ENOG4105K63 Thioredoxin bwei_4243 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein bwei_4245 ENOG4105C7N Xanthine uracil vitamin C permease bwei_4247 ENOG4108INS Transcriptional regulator bwei_4250 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) bwei_4251 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) bwei_4255 ENOG4105DWF phosphomethylpyrimidine kinase bwei_4256 ENOG4105D06 uba thif-type nad fad binding protein bwei_4259 ENOG41080HI glycine oxidase bwei_4260 ENOG4108VEU Thiamine monophosphate synthase bwei_4262 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component bwei_4264 ENOG4105ETU transcriptional activator (TenA bwei_4265 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase bwei_4268 ENOG41080XQ Signal transduction protein with cbs domains bwei_4277 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) bwei_4279 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) bwei_4280 ENOG410848D S4 domain protein YaaA bwei_4281 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) bwei_4282 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) bwei_4285 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) bwei_4286 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins bwei_4288 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) bwei_4289 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) bwei_4291 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) bwei_4292 ENOG4107QJE Chromosome Partitioning Protein bwei_4293 ENOG4105FA0 parb-like partition protein bwei_4294 ENOG4108ZDA Sporulation protein YyaC bwei_4295 ENOG4105D8X mechanosensitive ion channel bwei_4296 ENOG4105VDK protein, conserved in bacteria bwei_4297 ENOG4105C3G gtp-binding protein bwei_4298 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) bwei_4299 ENOG4108UUM single-stranded DNA-binding protein bwei_4301 ENOG4108XMW Membrane bwei_4302 ENOG4105BZR domain protein bwei_4303 ENOG4105K9Q Binds to the 23S rRNA (By similarity) bwei_4304 ENOG4105CDU Replicative dna helicase bwei_4305 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis bwei_4310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_4311 ENOG4105BZU Histidine kinase bwei_4314 ENOG4105Q2H domain protein bwei_4315 ENOG4105C0H protease bwei_4317 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) bwei_4319 ENOG4105DPN Oligoendopeptidase f bwei_4322 ENOG4105C1J atp-dependent rna helicase bwei_4324 ENOG4108UT2 hemolysin iii bwei_4325 ENOG4105CMR udp-glucose 4-epimerase bwei_4333 ENOG4105IW1 AmiS UreI transporter bwei_4335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) bwei_4338 ENOG4107RGD Major Facilitator superfamily bwei_4339 ENOG4108HRK Histidine kinase bwei_4340 ENOG4105DY9 regulatoR bwei_4341 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) bwei_4343 ENOG4106F5Q Membrane bwei_4344 ENOG4105E0X reductase bwei_4346 ENOG41067SE Tetr family transcriptional regulator bwei_4347 ENOG4105C5H ABC transporter bwei_4348 ENOG4108IG5 Transcriptional regulator bwei_4350 ENOG4105CKK Glycosyl transferase, family 2 bwei_4351 ENOG4105EJV Membrane bwei_4353 ENOG4105K64 Glycosyl transferase, family 2 bwei_4355 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) bwei_4356 ENOG4108S4H thioesterase Superfamily protein bwei_4358 ENOG4106YBV Methyl-accepting chemotaxis bwei_4359 ENOG4105EN6 Membrane bwei_4361 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) bwei_4363 ENOG41079KZ Major Facilitator Superfamily bwei_4365 ENOG4105DY9 regulatoR bwei_4366 ENOG4105D22 carbon starvation protein bwei_4367 ENOG4105VCD cytoplasmic protein bwei_4368 ENOG4105BZU Histidine kinase bwei_4369 ENOG4105DWF phosphomethylpyrimidine kinase bwei_4370 ENOG4105BZU Histidine kinase bwei_4371 ENOG4105WH1 Two component transcriptional regulator luxr family bwei_4373 ENOG4108Y4K DNA-binding transcriptional activator bwei_4378 ENOG4105CVG Homoserine O-transsuccinylase bwei_4379 ENOG4105D6E homoserine dehydrogenase bwei_4382 ENOG41090WU lipolytic protein G-D-S-L family bwei_4383 ENOG4105CJ1 ABC, transporter bwei_4384 ENOG4108TU7 Inherit from COG: (ABC) transporter bwei_4385 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) bwei_4386 ENOG4105VCH membrane bwei_4387 ENOG410667J hydrolase bwei_4389 ENOG4107SVH Potassium channel protein bwei_4393 ENOG4108VKI Cell wall hydrolase bwei_4395 ENOG4107JTW chlorite dismutase bwei_4396 ENOG4108IJ2 phosphate acetyltransferase bwei_4397 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) bwei_4398 ENOG4108VCI transcription factor, rsfa family bwei_4400 ENOG4105DQ5 transport system permease protein bwei_4401 ENOG4105EHG Permease protein bwei_4402 ENOG4105E0A ABC, transporter bwei_4403 ENOG4108MES Periplasmic binding protein bwei_4404 ENOG4105DCI Phosphohydrolase bwei_4405 ENOG41069HH 4-oxalocrotonate tautomerase bwei_4406 ENOG4108Z4T Peptidase M50 bwei_4407 ENOG4108XFG YwhD family bwei_4408 ENOG4105BZ4 penicillin-binding protein bwei_4409 ENOG4108QXE glycerophosphoryl diester phosphodiesterase bwei_4410 ENOG4107SWG transcriptional regulator MERR family bwei_4411 ENOG4105DXB Major Facilitator superfamily bwei_4412 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) bwei_4413 ENOG4105CYW agmatinase bwei_4417 ENOG410684U Domain of unknown function (DUF1934) bwei_4420 ENOG4105IIU Aminopeptidase bwei_4421 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) bwei_4422 ENOG4108M15 ABC transporter bwei_4423 ENOG4105KCT ABC transporter bwei_4424 ENOG4105BZU Histidine kinase bwei_4426 ENOG4105D4Y metalloprotease bwei_4429 ENOG4105BZU Histidine kinase bwei_4430 ENOG4105E5J UV damage endonuclease bwei_4432 ENOG4105DF6 Fe-S oxidoreductase bwei_4434 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase bwei_4435 ENOG4105C1G acyl-Coa dehydrogenase bwei_4436 ENOG4105C1G acyl-Coa dehydrogenase bwei_4439 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) bwei_4444 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) bwei_4445 ENOG4105CBT Fructose-1,6-bisphosphatase bwei_4446 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) bwei_4448 ENOG4107104 thymidine kinase bwei_4451 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) bwei_4452 ENOG4108ZXQ stage ii sporulation protein r bwei_4454 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) bwei_4457 ENOG4107XC4 flavin reductase domain protein, FMN-binding bwei_4458 ENOG4108VGI doxx family bwei_4461 ENOG4108YZG isomerase bwei_4468 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) bwei_4470 ENOG4107ZFM Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) bwei_4471 ENOG4107XXH F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) bwei_4474 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) bwei_4478 ENOG4105D7V transposase bwei_4480 ENOG4105BZU Histidine kinase bwei_4481 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain bwei_4482 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) bwei_4483 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain bwei_4484 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) bwei_4485 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) bwei_4488 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) bwei_4489 ENOG4105D65 subunit l bwei_4490 ENOG4105C8S subunit m bwei_4491 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) bwei_4492 ENOG4106778 Protein of unknown function (DUF1146) bwei_4500 ENOG4105DY9 regulatoR bwei_4503 ENOG4105FRN stage II sporulation protein bwei_4505 ENOG4105MT0 Sporulation transcriptional regulator spoiiid bwei_4508 ENOG4107YJ4 chain length determinant protein bwei_4509 ENOG4105HTX biosynthesis protein bwei_4510 ENOG4107YJ4 chain length determinant protein bwei_4511 ENOG4108RB3 Capsular polysaccharide biosynthesis protein bwei_4512 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase bwei_4513 ENOG4105D3Q Sugar transferase bwei_4514 ENOG4105C6Y Udp-glucose 6-dehydrogenase bwei_4518 ENOG4105K64 Glycosyl transferase, family 2 bwei_4522 ENOG4108KGH TRANSCRIPTIONal bwei_4524 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_4525 ENOG41062D9 Histidine kinase bwei_4528 ENOG4105CXY transporter bwei_4532 ENOG4105C19 ABC transporter bwei_4533 ENOG4107RBB ABC transporter, permease bwei_4536 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_4542 ENOG4105C0D helicase bwei_4543 ENOG4105KBK Zinc finger, swim domain protein bwei_4548 ENOG41069ER domain protein bwei_4549 ENOG4105C94 Transporter bwei_4551 ENOG4107R8N Glycosyl transferase, family 2 bwei_4557 ENOG4105E0M Sulfatase bwei_4563 ENOG4105DAA L-lactate bwei_4564 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) bwei_4570 ENOG4107RSM transcriptional regulator bwei_4571 ENOG4105ECB domain protein bwei_4576 ENOG4105VZJ PTS System bwei_4578 ENOG4105VCP PTS System bwei_4580 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) bwei_4581 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) bwei_4583 ENOG4105CK1 PTS System bwei_4584 ENOG4105VCP PTS System bwei_4585 ENOG4105F8D glycoside hydrolase family 4 bwei_4589 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family bwei_4591 ENOG4105ESV Glycosyl transferase, family 4 bwei_4592 ENOG4105C6Y Udp-glucose 6-dehydrogenase bwei_4593 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase bwei_4594 ENOG4108KGH TRANSCRIPTIONal bwei_4595 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein bwei_4597 ENOG4105KVH Transcriptional regulator bwei_4600 ENOG41081UC Inherit from COG: Competence protein bwei_4601 ENOG4105VEQ Cold shock protein bwei_4602 ENOG4105MS2 ribosomal subunit Interface protein bwei_4605 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) bwei_4609 ENOG4105CAK Cell division ATP-binding protein ftsE bwei_4610 ENOG4105CRP Part of the ABC transporter FtsEX involved in bwei_4611 ENOG4105CN1 protease bwei_4613 ENOG4105BZ1 (ABC) transporter bwei_4616 ENOG4108WS4 fmn reductase bwei_4617 ENOG4108Z6Z Transcriptional regulator bwei_4618 ENOG4105DUM transcriptional regulator, lysR family bwei_4625 ENOG4107TXC Transcriptional regulator bwei_4629 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) bwei_4632 ENOG41086DT Membrane protein of unknown function bwei_4633 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) bwei_4634 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) bwei_4635 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) bwei_4636 ENOG4108S4C acetyltransferase bwei_4638 ENOG4105C3M thioredoxin reductase bwei_4640 ENOG4108Z4K mutator MutT protein bwei_4641 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) bwei_4642 ENOG4105CHW UPF0052 protein bwei_4643 ENOG4105CIE May be required for sporulation (By similarity) bwei_4644 ENOG4105KRI phosphocarrier protein (HPr bwei_4646 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) bwei_4647 ENOG4108QY0 Membrane bwei_4650 ENOG4105CZ3 stage V sporulation protein ad bwei_4651 ENOG41090VF Stage v sporulation protein ac bwei_4656 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) bwei_4660 ENOG4105BZA Phosphoglycerate kinase bwei_4661 ENOG4105CP7 Triose-phosphate isomerase bwei_4663 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) bwei_4664 ENOG4105DU0 nucleoside hydrolase bwei_4666 ENOG41067MG lrgb family bwei_4667 ENOG4105XZU Preprotein translocase, subunit SecG bwei_4669 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) bwei_4674 ENOG4105CM4 permease protein bwei_4675 ENOG4108IPW abc transporter atp-binding protein bwei_4678 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) bwei_4679 ENOG4108V2W Carbonate dehydratase bwei_4681 ENOG4105KVH Transcriptional regulator bwei_4682 ENOG4108VY7 phosphate-starvation-inducible protein PsiE bwei_4683 ENOG4108MK9 spermidine N(1)-acetyltransferase bwei_4686 ENOG4105WMR Protein CrcB homolog bwei_4687 ENOG4105WMR Protein CrcB homolog bwei_4689 ENOG4105C8Q Methyl-accepting chemotaxis bwei_4691 ENOG4105D4A Cell wall formation (By similarity) bwei_4692 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) bwei_4695 ENOG4105KVH Transcriptional regulator bwei_4696 ENOG4105F27 Major Facilitator bwei_4697 ENOG4105CV8 reductase bwei_4700 ENOG4108RYK Nad-dependent epimerase dehydratase bwei_4704 ENOG4105D9N nucleoside bwei_4705 ENOG4105D9N nucleoside bwei_4707 ENOG41090A1 ferritin bwei_4709 ENOG4108URH decarboxylase bwei_4716 ENOG4108RMU ferritin dps family protein bwei_4719 ENOG4105NCW Trka-c domain protein bwei_4720 ENOG4107S91 Sodium hydrogen exchanger bwei_4725 ENOG4105D4Y metalloprotease bwei_4726 ENOG4105VG1 fes assembly suf system protein bwei_4727 ENOG4105C8Q Methyl-accepting chemotaxis bwei_4728 ENOG4105C8Q Methyl-accepting chemotaxis bwei_4730 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) bwei_4733 ENOG4105BZU Histidine kinase bwei_4734 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_4735 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein bwei_4737 ENOG4107ZTW SNARE associated Golgi bwei_4743 ENOG4107AYK membrAne bwei_4745 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins bwei_4749 ENOG4107R7I amino acid bwei_4750 ENOG4108SUT Major Facilitator Superfamily bwei_4753 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer bwei_4757 ENOG4105DZ1 carboxypeptidase bwei_4760 ENOG4105CHU acetyl-coa acetyltransferase bwei_4761 ENOG4105C1G acyl-Coa dehydrogenase bwei_4762 ENOG4108W8B Beta-lactamase domain protein bwei_4777 ENOG41080E8 Transcriptional regulator, Spx MgsR family bwei_4778 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) bwei_4785 ENOG4108UMI ABC transporter, permease bwei_4786 ENOG4105D01 (LipO)protein bwei_4787 ENOG4105D01 (LipO)protein bwei_4788 ENOG4105C3K feS assembly ATPase SufC bwei_4789 ENOG4105JRK feS assembly protein SufD bwei_4790 ENOG4105C9B Cysteine desulfurase bwei_4791 ENOG4108UNV SUF system FeS assembly protein, NifU family bwei_4792 ENOG4105DIW FeS assembly protein SUFB bwei_4793 ENOG4107R8B 5'-nucleotidase bwei_4794 ENOG4105KZD Domain of unknown function (DUF1805) bwei_4795 ENOG4108YTE sporulation protein YunB bwei_4796 ENOG4105FAA peptidase M23 bwei_4797 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) bwei_4801 ENOG41090T1 Membrane bwei_4802 ENOG4107TXC Transcriptional regulator bwei_4803 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) bwei_4804 ENOG4105MMD transcriptional regulator bwei_4808 ENOG4105CBT Fructose-1,6-bisphosphatase bwei_4811 ENOG4105D4U had-superfamily hydrolase, subfamily iia bwei_4817 ENOG4108W5N phosphatidylglycerophosphatase a bwei_4820 ENOG41083MR nifu domain-containing protein bwei_4826 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA bwei_4827 ENOG4105C4B ABC transporter, permease bwei_4828 ENOG4108JJA ABC, transporter bwei_4832 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) bwei_4833 ENOG4108YX9 iron--sulfur cluster insertion protein erpA bwei_4837 ENOG4105EWC Purine nucleoside phosphorylase bwei_4842 ENOG4105CEP NADH dehydrogenase bwei_4845 ENOG41069ER domain protein bwei_4846 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) bwei_4849 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase bwei_4852 ENOG4105KA0 thioesterase Superfamily protein bwei_4853 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) bwei_4856 ENOG4107R3E Citrate transporter bwei_4858 ENOG4105Y38 Kinase-associated protein B bwei_4861 ENOG4105C87 Aminotransferase class I and II bwei_4863 ENOG4108MUZ hydrolase bwei_4864 ENOG4105C5I Dehydrogenase bwei_4865 ENOG4108ZB6 transcriptional regulator AsnC family bwei_4866 ENOG4105CHM Aminotransferase bwei_4869 ENOG4105WG9 Conserved Protein bwei_4870 ENOG4107S5H glucose-6-phosphate isomerase bwei_4871 ENOG4107PBV potassium channel bwei_4873 ENOG4105KT7 mgtC SapB transporter bwei_4877 ENOG4105E2Z phosphate ABC transporter (Permease bwei_4878 ENOG4105C8U phosphate abc transporter bwei_4879 ENOG4105CVA phosphate bwei_4881 ENOG4105CE1 Ferrous iron transport protein b bwei_4882 ENOG4105CE1 Ferrous iron transport protein b bwei_4884 ENOG4108NHD germination protein bwei_4887 ENOG4105E1V na solute symporter bwei_4888 ENOG4106CAD Protein of unknown function (DUF3311) bwei_4891 ENOG4108IQI permease bwei_4892 ENOG4105E2S oxidase) subunit II bwei_4893 ENOG4105BZ9 Cytochrome C oxidase, subunit I bwei_4894 ENOG4105CCU oxidase (Subunit III) bwei_4898 ENOG4105MA6 gCN5-related N-acetyltransferase bwei_4901 ENOG4105C7N Xanthine uracil vitamin C permease bwei_4902 ENOG4105C85 amino acid bwei_4906 ENOG4105DUX Transporter bwei_4910 ENOG4105VZ8 Transcriptional regulator bwei_4911 ENOG41069ER domain protein bwei_4912 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer bwei_4913 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) bwei_4920 ENOG4108QYW Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture. Beta-hemolysin is a phospholipase C with specific activity toward sphingomyelins. Has a high specificity for sphingomyelin, hydrolyzes lysophosphatidylcholine at a much lower rate, but has no activity towards phosphatidylcholine, phosphatidylethanolamine, or phosphatidylserine (By similarity) bwei_4924 ENOG4105C6X Major Facilitator bwei_4928 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) bwei_4929 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator bwei_4930 ENOG4105CNN ABC, transporter bwei_4931 ENOG4105C2J ABC transporter bwei_4932 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) bwei_4933 ENOG4108RVA ribokinase bwei_4934 ENOG4105ETE Transcriptional regulator (LacI family bwei_4935 ENOG4105C0R drug resistance transporter emrb qaca subfamily bwei_4936 ENOG41067TZ transcriptional regulator, MarR family bwei_4937 ENOG4105CXY transporter bwei_4939 ENOG4108JQ7 (ABC) transporter bwei_4940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component bwei_4944 ENOG41068KF Universal stress protein bwei_4945 ENOG4105CHH sulfate transporter bwei_4948 ENOG4105BZU Histidine kinase bwei_4949 ENOG4105NAE bifunctional deaminase-reductase domain protein bwei_4950 ENOG4105D29 Helix-turn-helix type 11 domain protein bwei_4955 ENOG4108IQI permease bwei_4956 ENOG4105DRP amino acid AbC transporter bwei_4957 ENOG4105EAD ABC transporter bwei_4958 ENOG4105CT1 (ABC) transporter bwei_4959 ENOG4105CDA abc transporter atp-binding protein bwei_4960 ENOG4105BZG amino acid carrier protein bwei_4961 ENOG4105CRN Aminoglycoside phosphotransferase bwei_4964 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin bwei_4965 ENOG4105WH1 Two component transcriptional regulator luxr family bwei_4966 ENOG4108XG2 Histidine kinase bwei_4967 ENOG4105E1K spore germination protein bwei_4970 ENOG4105CG3 alpha amylase, catalytic region bwei_4971 ENOG4105C5Y PTS System bwei_4972 ENOG4107414 GntR family transcriptional regulator bwei_4973 ENOG4105D5Q Arginine ornithine antiporter bwei_4974 ENOG4105BZU Histidine kinase bwei_4976 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) bwei_4977 ENOG4105GMT ATPase associated with various cellular activities aaa_5 bwei_4978 ENOG4107T89 von Willebrand factor, type A bwei_4980 ENOG4105EXW epimerase dehydratase bwei_4982 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) bwei_4983 ENOG4105E0A ABC, transporter bwei_4984 ENOG4108IHU transport system permease protein bwei_4985 ENOG4105DQ5 transport system permease protein bwei_4986 ENOG4108MES Periplasmic binding protein bwei_4987 ENOG4105DUX Transporter bwei_4990 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bwei_4991 ENOG4105DAA L-lactate bwei_4992 ENOG4108IJ0 Aspartate ammonia-lyase bwei_4993 ENOG4105C37 (CBS) domain bwei_4994 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase bwei_4995 ENOG4105D9N nucleoside bwei_4996 ENOG4108KGH TRANSCRIPTIONal bwei_4997 ENOG41073R8 VanW family bwei_5005 ENOG4105DAP Nicotinate phosphoribosyltransferase bwei_5006 ENOG4105C59 p-type ATPase bwei_5009 ENOG4105CUB amino acid bwei_5014 ENOG4108JB9 formate dehydrogenase bwei_5015 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) bwei_5017 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) bwei_5019 ENOG4105CK6 Two component transcriptional regulator (Winged helix family bwei_5020 ENOG4105BZU Histidine kinase bwei_5022 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family bwei_5023 ENOG4108UZ3 Transporter bwei_5025 ENOG4105C6K Malic enzyme bwei_5027 ENOG4108MRH transcriptional regulatory protein bwei_5032 ENOG4105US7 Histidine kinase bwei_5033 ENOG4108STX response regulator bwei_5034 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) bwei_5035 ENOG4105BZ7 extracellular solute-binding protein family 1 bwei_5036 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component bwei_5037 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component bwei_5038 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) bwei_5039 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator bwei_5044 ENOG4105D4T Citrate transporter bwei_5045 ENOG4108V9W transcriptional regulatory protein bwei_5046 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism bwei_5048 ENOG4105DZ6 Band 7 protein bwei_5052 ENOG4106AKX UPF0229 protein bwei_5053 ENOG4105CYN Serine protein kinase bwei_5054 ENOG4105BZU Histidine kinase bwei_5055 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) bwei_5057 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) bwei_5059 ENOG4107ZQN disulfide bond bwei_5060 ENOG4108JQC penicillin-binding protein 1A bwei_5104 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) bwei_5105 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit bwei_5106 ENOG4105C83 adenylosuccinate lyase bwei_5107 ENOG4105C8V SAICAR synthetase bwei_5108 ENOG4105VR9 phosphoribosylformylglycinamidine synthase bwei_5109 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I bwei_5110 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii bwei_5112 ENOG4105CXB phosphoribosylaminoimidazole synthetase bwei_5113 ENOG4108V3E phosphoribosylglycinamide formyltransferase bwei_5114 ENOG4105DC1 bifunctional purine biosynthesis protein purh bwei_5115 ENOG4105C12 Phosphoribosylglycinamide synthetase bwei_5120 ENOG4105C4R Atp-dependent dna helicase bwei_5121 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) bwei_5124 ENOG4105C26 Dehydrogenase bwei_5125 ENOG4108W2Y isochorismatase bwei_5127 ENOG4108UMI ABC transporter, permease bwei_5128 ENOG4105D01 (LipO)protein bwei_5132 ENOG41067TZ transcriptional regulator, MarR family bwei_5133 ENOG4107I77 yiaA/B two helix domain bwei_5135 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) bwei_5136 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) bwei_5137 ENOG4105CBD Diacylglycerol kinase bwei_5139 ENOG4108JPW Aminotransferase bwei_5141 ENOG4105C26 Dehydrogenase bwei_5142 ENOG4105KPY Small multidrug resistance protein bwei_5147 ENOG4105D9N nucleoside bwei_5148 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) bwei_5151 ENOG4105BZU Histidine kinase bwei_5153 ENOG4108W15 Protein of unknown function (DUF1456) bwei_5156 ENOG4105DTQ mandelate racemase muconate lactonizing bwei_5157 ENOG4105DFD Na H antiporter bwei_5162 ENOG4105D3R alkyl hydroperoxide reductase bwei_5163 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) bwei_5164 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) bwei_5165 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase bwei_5166 ENOG4105EHG Permease protein bwei_5167 ENOG4105DQ5 transport system permease protein bwei_5168 ENOG4108V5C ABC transporter bwei_5169 ENOG4105CAY ferredoxin--nadp reductase bwei_5172 ENOG4106UIA bwei_5173 ENOG4106UIA bwei_5176 ENOG4105BZU Histidine kinase bwei_5181 ENOG410756H nucleotidyltransferase bwei_5184 ENOG4105E5Q amino acid AbC transporter bwei_5185 ENOG4105EAB amino acid AbC transporter bwei_5187 ENOG4105C8Q Methyl-accepting chemotaxis bwei_5190 ENOG4105DBV ornithine carbamoyltransferase bwei_5192 ENOG4105C5B carbamate kinase bwei_5195 ENOG4105DNP FAD linked oxidase domain protein bwei_5197 ENOG4105CI1 PTS System bwei_5200 ENOG4105C9U ATP-dependent DNA helicase RecQ bwei_5201 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase bwei_5202 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) bwei_5203 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter bwei_5206 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component bwei_5207 ENOG4105D2X ABC transporter substrate-binding protein bwei_5209 ENOG4105C5H ABC transporter bwei_5214 ENOG41062JF Transcriptional regulator bwei_5217 ENOG4105DEU major facilitator superfamily bwei_5223 ENOG4108N0M stress protein bwei_5224 ENOG4106FN3 tellurium resistance protein bwei_5225 ENOG4106FN3 tellurium resistance protein bwei_5226 ENOG4107TS3 membrane protein, TerC bwei_5227 ENOG4108TTB tellurium resistance protein bwei_5231 ENOG4105KJF protein tyrosine phosphatase bwei_5233 ENOG4107U9T Pfam:Ribonuclease_BN bwei_5234 ENOG4105C59 p-type ATPase bwei_5235 ENOG4108IPJ Membrane bwei_5239 ENOG4107ZTW SNARE associated Golgi bwei_5242 ENOG410606W general stress protein bwei_5243 ENOG4105UPD Calcium Proton bwei_5251 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) bwei_5253 ENOG4108JUB Transcriptional regulator bwei_5255 ENOG4108IQI permease bwei_5261 ENOG4105CSV Glutaminase bwei_5263 ENOG4108A04 Beta-lactamase bwei_5267 ENOG4107R51 Glycosyl transferase, family 2 bwei_5268 ENOG4107QQG Dehydrogenase bwei_5269 ENOG4108I2E Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) bwei_5270 ENOG4105CKK Glycosyl transferase, family 2 bwei_5273 ENOG4105F1A Pyruvate formate-lyase bwei_5274 ENOG4108QBV Monogalactosyldiacylglycerol synthase bwei_5277 ENOG4105CI2 imidazolone-5-propionate hydrolase bwei_5278 ENOG4105ECP epimerase bwei_5284 ENOG41067AE Membrane-bound metal-dependent hydrolase bwei_5285 ENOG4105CEN a g-specific adenine glycosylase bwei_5286 ENOG4106BXE bwei_5290 ENOG4105BZ1 (ABC) transporter bwei_5291 ENOG4107NBY Membrane bwei_5292 ENOG4105CBC glutamate synthase bwei_5294 ENOG4108IUW ABC transporter bwei_5298 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen bwei_5299 ENOG4105G5W regulator Fur family bwei_5304 ENOG4107ZXU DSBA oxidoreductase bwei_5305 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein bwei_5313 ENOG4105W8Z 4'-phosphopantetheinyl transferase bwei_5315 ENOG4105CHR reductase bwei_5320 ENOG4108XZ3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division (By similarity) bwei_5321 ENOG4108BUD transposase bwei_5322 ENOG4105U5Y Transcriptional regulator bwei_5323 ENOG4105K4H Nlp p60 protein bwei_5326 ENOG4105D8G Major Facilitator superfamily bwei_5335 ENOG4105D7V transposase bwei_5347 ENOG4108KXV response regulator bwei_5348 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) bwei_5361 ENOG4105U5Y Transcriptional regulator bwei_5367 ENOG4106PZP Bacillus haemolytic enterotoxin (HBL) bwei_5377 ENOG4105D7V transposase bwei_5379 ENOG4107HBJ phospholipase C bwei_5383 ENOG4105D7V transposase bwei_5387 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase bwei_5391 ENOG4108BUD transposase bwei_5401 ENOG4108UGV hypoxanthine phosphoribosyltransferase bwei_5405 ENOG4108N23 SpoOM-related protein bwei_5421 ENOG4108KGH TRANSCRIPTIONal bwei_5424 ENOG4105DG6 mannose-6-phosphate isomerase bwei_5425 ENOG4105CJT Mannose-1-phosphate guanylyltransferase bwei_5426 ENOG4105C6Y Udp-glucose 6-dehydrogenase bwei_5428 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF bwei_5429 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) bwei_5434 ENOG4105C0K Gdp-mannose 4,6-dehydratase bwei_5435 ENOG4105C30 Nad-dependent epimerase dehydratase bwei_5436 ENOG4105D3Q Sugar transferase bwei_5437 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase bwei_5438 ENOG4108RB3 Capsular polysaccharide biosynthesis protein bwei_5439 ENOG4107YJ4 chain length determinant protein bwei_5440 ENOG4105HTX biosynthesis protein bwei_5452 ENOG4105D7V transposase bwei_5464 ENOG4105CHH sulfate transporter bwei_5467 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA bwei_5469 ENOG4108VY7 phosphate-starvation-inducible protein PsiE bwei_5488 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) bwei_5490 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) bwei_5491 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein bwei_5492 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) bwei_5497 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) bwei_5498 ENOG4105CPF Cell wall formation (By similarity) bwei_5499 ENOG4108SC4 )-transporter bwei_5502 ENOG4105ERH Fumarylacetoacetate hydrolase bwei_5503 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase bwei_5506 ENOG410667J hydrolase bwei_5507 ENOG4108JQ7 (ABC) transporter bwei_5508 ENOG4105C3U ABC transporter bwei_5509 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bwei_5515 ENOG4108KYE ABC-2 type transporter bwei_5516 ENOG41090VJ ABC-2 type transporter bwei_5517 ENOG4105CJ1 ABC, transporter bwei_5519 ENOG4105WH1 Two component transcriptional regulator luxr family bwei_5520 ENOG4105BZU Histidine kinase bwei_5521 ENOG4105C5H ABC transporter bwei_5525 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) bwei_5529 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) bwei_5531 ENOG4105F6E Acyl-transferase bwei_5535 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family bwei_5536 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein bwei_5537 ENOG4105E0C molybdate abc transporter bwei_5539 ENOG4106Z1T Nicotinamide Mononucleotide Transporter bwei_5540 ENOG4105II7 pyrroline-5-carboxylate reductase bwei_5543 ENOG4108J59 Extracellular solute-binding protein, family 5 bwei_5544 ENOG4108J59 Extracellular solute-binding protein, family 5 bwei_5548 ENOG4108JQ7 (ABC) transporter bwei_5549 ENOG4105C3U ABC transporter bwei_5550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component bwei_5551 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component bwei_5554 ENOG4105C2C drug resistance transporter, Bcr CflA bwei_5557 ENOG4105IQ5 FAD linked oxidase domain protein bwei_5559 ENOG4105EE1 crotonyl-CoA reductase bwei_5560 ENOG4105D01 (LipO)protein bwei_5562 ENOG4108UMI ABC transporter, permease bwei_5563 ENOG4108PSK reductase bwei_5569 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein bwei_5570 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) bwei_5571 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) bwei_5572 ENOG4107U5W ybbr family bwei_5573 ENOG4105C8B TIGR00159 family bwei_5583 ENOG4108Z0C Uvrb UvrC protein bwei_5586 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) bwei_5587 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) bwei_5588 ENOG4105CTP PilT protein domain protein bwei_5589 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) bwei_5591 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) bwei_5592 ENOG4105D7W serine acetyltransferase bwei_5593 ENOG4105C8N cysteinyl-tRNA synthetase bwei_5595 ENOG4105C2N RNA methyltransferase TrmH family group 3 bwei_5596 ENOG4105M0M Tetracycline resistance protein bwei_5597 ENOG4105QIV RNA polymerase bwei_5599 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) bwei_5601 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) bwei_5602 ENOG4108VZM 50s ribosomal protein L10 bwei_5603 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) bwei_5604 ENOG4107Y49 methyltransferase bwei_5605 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) bwei_5606 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) bwei_5607 ENOG4105XPM ribosomal protein bwei_5610 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) bwei_5611 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) bwei_5615 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) bwei_5617 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity bwei_5618 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) bwei_5619 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) bwei_5622 ENOG41082SA 50s ribosomal protein l29 bwei_5623 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal bwei_5625 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) bwei_5626 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits bwei_5628 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) bwei_5629 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) bwei_5630 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) bwei_5632 ENOG4105VPB 50S ribosomal protein L30 bwei_5633 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) bwei_5634 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) bwei_5636 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) bwei_5638 ENOG41067V7 50S ribosomal protein L36 bwei_5640 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) bwei_5644 ENOG4108JJB ABC transporter bwei_5645 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) bwei_5646 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) bwei_5647 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) bwei_5648 ENOG4108UJD 30S ribosomal protein S9 bwei_5651 ENOG4105D1F ATP-binding protein bwei_5654 ENOG4108NMV polysaccharide deacetylase bwei_5656 ENOG4105CXN decarboxylase bwei_5657 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) bwei_5658 ENOG4105FA2 dna polymerase iii bwei_5659 ENOG4105MA4 psp1 domain protein bwei_5661 ENOG41060K3 Methyltransferase bwei_5663 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) bwei_5664 ENOG4105KRN Transcriptional regulator, abrb family bwei_5665 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) bwei_5666 ENOG4105F8V Hydrolase, tatD family bwei_5667 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) bwei_5668 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) bwei_5669 ENOG4105XFA sporulation peptidase YabG bwei_5670 ENOG4105W42 Veg protein bwei_5672 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) bwei_5673 ENOG4105DFT pur operon repressor bwei_5674 ENOG4105KME endoribonuclease L-psp bwei_5676 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) bwei_5677 ENOG4105C5T Phosphoribosyl pyrophosphate synthase bwei_5680 ENOG4108JA2 transcriptioN-repair coupling factor bwei_5681 ENOG4108M14 stage v sporulation protein t bwei_5683 ENOG4108IY2 MazG family bwei_5684 ENOG41082I2 s4 domain protein bwei_5685 ENOG4105VYY sporulation protein yabp bwei_5688 ENOG41060GV RNA binding s1 domain protein bwei_5692 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) bwei_5693 ENOG4108UGV hypoxanthine phosphoribosyltransferase bwei_5694 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) bwei_5695 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) bwei_5696 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) bwei_5697 ENOG4105C6T cysteine synthase bwei_5698 ENOG4105CRQ synthase (Component I) bwei_5699 ENOG4105DDQ anthranilate synthase bwei_5700 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 bwei_5701 ENOG4105EEI dihydropteroate synthase bwei_5702 ENOG4105KRF dihydroneopterin aldolase bwei_5703 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase bwei_5705 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) bwei_5706 ENOG4105CRK lysyL-tRNA synthetase bwei_5709 ENOG4105BZU Histidine kinase bwei_5711 ENOG4105KNE Phosphatidate cytidylyltransferase bwei_5712 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) bwei_5723 ENOG4108FQ0 the rest of the oligosaccharide is released intact. Cleaves the peptidoglycan connecting the daughter cells at the end of the cell division cycle, resulting in the separation of the two newly divided cells. Acts as an autolysin in penicillin-induced lysis bwei_5731 ENOG4105CNU cell division protein FtsK bwei_5753 ENOG4107R0E Glycosyl transferase, family 2 bwei_5763 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) bwei_5771 ENOG41067XF inhibitor bwei_5775 ENOG41088T4 Helicase IV bwei_5784 ENOG4105FCD Major Facilitator bwei_5791 ENOG4105DQ6 Transposase bwei_5792 ENOG4105DQ6 Transposase bwei_5794 ENOG4108BUD transposase bwei_5795 ENOG4105KRN Transcriptional regulator, abrb family bwei_5799 ENOG4105K8N protein family UPF0079, ATPase bwei_5800 ENOG41072GX Peptidase M22 Glycoprotease bwei_5801 ENOG410801F ribosomal-protein-alanine acetyltransferase bwei_5803 ENOG4105C5H ABC transporter bwei_5806 ENOG4108TYN CAAX amino terminal protease family protein bwei_5808 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) bwei_5809 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) bwei_5810 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) bwei_5811 ENOG4105C7N Xanthine uracil vitamin C permease bwei_5813 ENOG4105BZU Histidine kinase bwei_5815 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) bwei_5817 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) bwei_5818 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) bwei_5822 ENOG4105ZMH deoxynucleoside kinase bwei_5824 ENOG4105GTG Isochorismatase bwei_5825 ENOG4108Z6B deaminase bwei_5826 ENOG4105C6E dna polymerase iii bwei_5827 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) bwei_5828 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) bwei_5830 ENOG41067KS pro-sigma K processing bwei_5845 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) bwei_5849 ENOG4108SHN Glycosyl transferase, family 2 bwei_5850 ENOG4107QSN dihydrolipoamide acetyltransferase bwei_5854 ENOG4107QN2 dihydrolipoyl dehydrogenase bwei_5855 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) bwei_5865 ENOG4105SX7 Transporter