locus-tag	class	description
I5818_00010	COG0592	DNA-directed DNA polymerase activity
I5818_00015	COG2501	S4 domain
I5818_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5818_00030	COG0187	DNA topoisomerase II activity
I5818_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5818_00075	COG0516	GMP reductase activity
I5818_00075	COG0517	IMP dehydrogenase activity
I5818_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
I5818_00100	COG1428	Deoxynucleoside kinase
I5818_00105	COG1428	Deoxynucleoside kinase
I5818_00110	COG3858	chitin binding
I5818_00110	COG1388	LysM domain
I5818_00115	COG0590	tRNA wobble adenosine to inosine editing
I5818_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I5818_00130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I5818_00135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I5818_00180	COG1982	Orn Lys Arg decarboxylase major
I5818_00185	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I5818_00190	COG3870	Protein conserved in bacteria
I5818_00195	COG1728	Protein conserved in bacteria
I5818_00200	COG0470	DNA polymerase III
I5818_00205	COG1774	PSP1 C-terminal conserved region
I5818_00210	COG4467	Involved in initiation control of chromosome replication
I5818_00215	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I5818_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I5818_00225	COG2002	toxin-antitoxin pair type II binding
I5818_00235	COG0084	hydrolase, TatD family'
I5818_00240	COG3583	domain protein
I5818_00240	COG3584	3D domain protein
I5818_00260	COG4466	Protein conserved in bacteria
I5818_00270	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I5818_00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5818_00280	COG0251	oxidation-reduction process
I5818_00285	COG2088	sporulation resulting in formation of a cellular spore
I5818_00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I5818_00300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I5818_00315	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I5818_00320	COG2002	toxin-antitoxin pair type II binding
I5818_00325	COG2244	polysaccharide biosynthetic process
I5818_00330	COG3956	TIGRFAM MazG family protein
I5818_00335	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I5818_00355	COG1098	S1 RNA binding domain
I5818_00370	COG2208	phosphoserine phosphatase activity
I5818_00375	COG2304	oxidoreductase activity
I5818_00380	COG0515	serine threonine protein kinase
I5818_00390	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I5818_00395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5818_00400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
I5818_00405	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I5818_00410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_00415	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I5818_00420	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I5818_00425	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I5818_00430	COG1396	sequence-specific DNA binding
I5818_00520	COG3880	PFAM UvrB UvrC protein
I5818_00525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
I5818_00530	COG0542	response to heat
I5818_00535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I5818_00540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
I5818_00545	COG4956	integral membrane protein (PIN domain superfamily)
I5818_00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I5818_00555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
I5818_00560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5818_00565	COG1045	serine acetyltransferase
I5818_00570	COG0215	cysteine-tRNA ligase activity
I5818_00580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5818_00585	COG3688	RNA-binding protein containing a PIN domain
I5818_00595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5818_00600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5818_00605	COG0250	Participates in transcription elongation, termination and antitermination
I5818_00610	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I5818_00615	COG0081	regulation of translation
I5818_00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I5818_00625	COG0222	ribosome binding
I5818_00630	COG2813	Specifically methylates the guanine in position
I5818_00635	COG0085	RNA polymerase activity
I5818_00645	COG1358	cellular component organization or biogenesis
I5818_00650	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I5818_00655	COG0049	tRNA binding
I5818_00665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I5818_00670	COG0051	transcription antitermination factor activity, RNA binding
I5818_00680	COG0088	Forms part of the polypeptide exit tunnel
I5818_00685	COG0089	rRNA binding
I5818_00690	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I5818_00695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I5818_00700	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I5818_00705	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I5818_00710	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I5818_00715	COG0255	Belongs to the universal ribosomal protein uL29 family
I5818_00720	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I5818_00725	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I5818_00730	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I5818_00735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I5818_00740	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5818_00745	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I5818_00750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I5818_00755	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I5818_00760	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I5818_00765	COG1841	ribosomal large subunit assembly
I5818_00775	COG0201	protein transport
I5818_00780	COG0563	adenylate kinase activity
I5818_00790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I5818_00795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I5818_00800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I5818_00810	COG0202	RNA polymerase activity
I5818_00815	COG0203	ribosomal protein L17
I5818_00820	COG1122	ATPase activity
I5818_00825	COG1122	ATPase activity
I5818_00830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5818_00835	COG0101	tRNA pseudouridine synthase activity
I5818_00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I5818_00845	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I5818_00880	COG3403	YqcI/YcgG family
I5818_00895	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_00900	COG0489	protein tyrosine kinase activity
I5818_00910	COG2194	sulfuric ester hydrolase activity
I5818_00915	COG0726	polysaccharide deacetylase
I5818_00985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5818_00995	COG1595	DNA-templated transcription, initiation
I5818_01000	COG5662	AntiSigma factor
I5818_01005	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I5818_01010	COG4856	YbbR-like protein
I5818_01015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5818_01020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5818_01040	COG0784	Response regulator, receiver
I5818_01040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_01040	COG2198	Histidine kinase
I5818_01040	COG2205	protein histidine kinase activity
I5818_01070	COG5504	Zn-dependent protease
I5818_01105	COG0798	PFAM Bile acid sodium symporter
I5818_01110	COG0640	Transcriptional regulator
I5818_01115	COG1388	LysM domain
I5818_01125	COG2814	Major facilitator Superfamily
I5818_01130	COG2226	methyltransferase
I5818_01140	COG0488	(ABC) transporter
I5818_01150	COG0789	Transcriptional regulator
I5818_01150	COG4978	Transcriptional regulator
I5818_01155	COG1349	DNA-binding transcription factor activity
I5818_01160	COG1105	Belongs to the carbohydrate kinase PfkB family
I5818_01165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_01165	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_01165	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_01170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_01175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_01185	COG0017	Asparaginyl-tRNA synthetase
I5818_01200	COG0662	Cupin 2, conserved barrel domain protein
I5818_01225	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_01235	COG0640	Transcriptional regulator
I5818_01250	COG1114	Component of the transport system for branched-chain amino acids
I5818_01260	COG1802	Transcriptional regulator
I5818_01275	COG4122	O-methyltransferase activity
I5818_01290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_01300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_01305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_01315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5818_01320	COG3832	glyoxalase III activity
I5818_01335	COG3226	Transcriptional regulator
I5818_01370	COG2076	Multidrug Resistance protein
I5818_01380	COG0519	Catalyzes the synthesis of GMP from XMP
I5818_01390	COG0406	alpha-ribazole phosphatase activity
I5818_01405	COG0477	Major facilitator Superfamily
I5818_01410	COG2226	methyltransferase
I5818_01420	COG1937	Protein conserved in bacteria
I5818_01430	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_01430	COG0425	Belongs to the sulfur carrier protein TusA family
I5818_01435	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_01435	COG0425	Belongs to the sulfur carrier protein TusA family
I5818_01440	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I5818_01445	COG2210	Belongs to the sulfur carrier protein TusA family
I5818_01450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_01450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_01455	COG0425	Belongs to the sulfur carrier protein TusA family
I5818_01460	COG0730	response to heat
I5818_01465	COG2207	Transcriptional regulator
I5818_01465	COG3708	Transcriptional regulator
I5818_01505	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5818_01525	COG1695	Transcriptional regulator
I5818_01535	COG0586	Pfam SNARE associated Golgi protein
I5818_01540	COG2807	transmembrane transport
I5818_01545	COG2186	Transcriptional regulator
I5818_01550	COG0745	RESPONSE REGULATOR receiver
I5818_01555	COG2205	protein histidine kinase activity
I5818_01560	COG1136	(ABC) transporter
I5818_01565	COG0577	efflux transmembrane transporter activity
I5818_01570	COG0840	transmembrane signaling receptor activity
I5818_01580	COG1131	(ABC) transporter
I5818_01585	COG2205	protein histidine kinase activity
I5818_01590	COG0745	RESPONSE REGULATOR receiver
I5818_01605	COG0789	Transcriptional regulator
I5818_01610	COG0745	RESPONSE REGULATOR receiver
I5818_01615	COG2205	protein histidine kinase activity
I5818_01620	COG1136	(ABC) transporter
I5818_01625	COG0577	efflux transmembrane transporter activity
I5818_01640	COG0783	Belongs to the Dps family
I5818_01645	COG0824	Thioesterase
I5818_01655	COG1609	Transcriptional regulator
I5818_01665	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5818_01680	COG0765	amino acid transport
I5818_01685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_01710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I5818_01715	COG2378	regulation of single-species biofilm formation
I5818_01720	COG3708	Transcriptional regulator
I5818_01725	COG0702	epimerase
I5818_01735	COG2197	response regulator
I5818_01740	COG4585	Histidine kinase
I5818_01745	COG0842	Transport permease protein
I5818_01750	COG1131	(ABC) transporter
I5818_01775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5818_01785	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I5818_01795	COG0423	glycine-tRNA ligase activity
I5818_01810	COG0833	amino acid
I5818_01815	COG0531	amino acid
I5818_01820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_01825	COG0628	permease
I5818_01835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_01840	COG0765	amino acid transport
I5818_01845	COG0765	amino acid transport
I5818_01855	COG3279	Response regulator of the LytR AlgR family
I5818_01860	COG4555	ABC transporter
I5818_01865	COG1668	transmembrane transport
I5818_01875	COG1090	epimerase
I5818_01880	COG0628	permease
I5818_01885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5818_01895	COG0791	NLP P60 protein
I5818_01895	COG1388	LysM domain
I5818_01900	COG1733	regulation of RNA biosynthetic process
I5818_01915	COG1131	(ABC) transporter
I5818_01935	COG1051	belongs to the nudix hydrolase family
I5818_01940	COG1346	cytolysis
I5818_01950	COG0583	DNA-binding transcription factor activity
I5818_01955	COG3339	Conserved Protein
I5818_01960	COG0586	Pfam SNARE associated Golgi protein
I5818_01975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5818_01990	COG1686	Belongs to the peptidase S11 family
I5818_01995	COG0069	glutamate synthase activity
I5818_02000	COG0697	spore germination
I5818_02010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_02015	COG0531	amino acid
I5818_02055	COG1376	ErfK ybiS ycfS ynhG family protein
I5818_02065	COG2011	ABC-type metal ion transport system permease component
I5818_02080	COG1114	Component of the transport system for branched-chain amino acids
I5818_02095	COG1132	(ABC) transporter
I5818_02105	COG5002	protein histidine kinase activity
I5818_02110	COG1131	(ABC) transporter
I5818_02140	COG0583	DNA-binding transcription factor activity
I5818_02145	COG0372	Belongs to the citrate synthase family
I5818_02150	COG1876	peptidase activity
I5818_02155	COG0640	Transcriptional regulator
I5818_02180	COG0726	polysaccharide deacetylase
I5818_02185	COG0004	ammonium transporteR
I5818_02190	COG0626	cystathionine gamma-synthase activity
I5818_02195	COG0626	cystathionine gamma-synthase activity
I5818_02200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I5818_02200	COG0646	methionine synthase
I5818_02205	COG0646	methionine synthase
I5818_02205	COG1410	methionine synthase
I5818_02210	COG1695	Transcriptional regulator
I5818_02225	COG0791	NLP P60 protein
I5818_02225	COG3883	PFAM NLP P60 protein
I5818_02230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I5818_02250	COG0183	Belongs to the thiolase family
I5818_02260	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_02280	COG0681	Belongs to the peptidase S26 family
I5818_02300	COG1404	Belongs to the peptidase S8 family
I5818_02310	COG1191	sigma factor activity
I5818_02335	COG1737	Transcriptional regulator
I5818_02350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I5818_02355	COG3383	formate dehydrogenase (NAD+) activity
I5818_02360	COG2223	nitrite transmembrane transporter activity
I5818_02370	COG4086	secreted protein
I5818_02375	COG4166	transmembrane transport
I5818_02380	COG0601	transmembrane transport
I5818_02385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_02390	COG0444	Belongs to the ABC transporter superfamily
I5818_02395	COG4608	Belongs to the ABC transporter superfamily
I5818_02405	COG2135	peptidase activity
I5818_02430	COG1263	PTS System
I5818_02430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_02430	COG2190	(PTS) system
I5818_02450	COG5002	protein histidine kinase activity
I5818_02455	COG0745	RESPONSE REGULATOR receiver
I5818_02460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_02465	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
I5818_02470	COG1335	isochorismatase
I5818_02475	COG0531	amino acid
I5818_02495	COG1960	acyl-CoA dehydrogenase activity
I5818_02525	COG2996	Protein conserved in bacteria
I5818_02530	COG1164	Oligoendopeptidase f
I5818_02545	COG2972	Histidine kinase
I5818_02550	COG4753	response regulator
I5818_02550	COG4753	response regulator
I5818_02550	COG2207	Transcriptional regulator
I5818_02550	COG2207	Transcriptional regulator
I5818_02555	COG0753	catalase activity
I5818_02560	COG0735	belongs to the Fur family
I5818_02565	COG0840	transmembrane signaling receptor activity
I5818_02575	COG1175	transmembrane transport
I5818_02580	COG0395	ABC-type sugar transport system, permease component
I5818_02585	COG0626	cystathionine gamma-synthase activity
I5818_02590	COG0656	L-ascorbic acid biosynthetic process
I5818_02595	COG2814	Major facilitator Superfamily
I5818_02600	COG1733	regulation of RNA biosynthetic process
I5818_02605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5818_02620	COG0477	Major facilitator Superfamily
I5818_02625	COG1404	Belongs to the peptidase S8 family
I5818_02625	COG4412	M6 family metalloprotease domain protein
I5818_02630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I5818_02640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5818_02645	COG2226	methyltransferase
I5818_02655	COG2076	Multidrug Resistance protein
I5818_02660	COG2076	Multidrug Resistance protein
I5818_02665	COG1309	transcriptional regulator
I5818_02675	COG0583	DNA-binding transcription factor activity
I5818_02700	COG1694	Mazg nucleotide pyrophosphohydrolase
I5818_02710	COG2226	methyltransferase
I5818_02730	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5818_02745	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I5818_02765	COG2816	NAD+ diphosphatase activity
I5818_02770	COG0357	Ribosomal RNA small subunit methyltransferase G
I5818_02780	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_02790	COG0592	DNA-directed DNA polymerase activity
I5818_02805	COG2610	gluconate transmembrane transporter activity
I5818_02810	COG1929	Belongs to the glycerate kinase type-1 family
I5818_02815	COG3835	regulator
I5818_02820	COG0346	lactoylglutathione lyase activity
I5818_02830	COG1690	Belongs to the RtcB family
I5818_02845	COG0326	Molecular chaperone. Has ATPase activity
I5818_02865	COG1533	DNA photolyase activity
I5818_02890	COG4294	response to UV
I5818_03055	COG2318	DinB family
I5818_03065	COG0693	protein deglycase activity
I5818_03080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_03085	COG2207	Transcriptional regulator
I5818_03085	COG3708	Transcriptional regulator
I5818_03095	COG1846	Transcriptional regulator
I5818_03105	COG0577	efflux transmembrane transporter activity
I5818_03110	COG1136	(ABC) transporter
I5818_03115	COG2207	Transcriptional regulator
I5818_03145	COG1741	Belongs to the pirin family
I5818_03150	COG2318	DinB family
I5818_03155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5818_03170	COG1289	transmembrane transporter activity
I5818_03175	COG0494	nUDIX hydrolase
I5818_03180	COG2514	catechol 2,3-dioxygenase activity
I5818_03190	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I5818_03235	COG2078	PFAM AMMECR1 domain protein
I5818_03235	COG3885	ferrous iron binding
I5818_03250	COG1115	amino acid carrier protein
I5818_03255	COG1063	alcohol dehydrogenase
I5818_03265	COG2318	DinB family
I5818_03280	COG1316	TRANSCRIPTIONal
I5818_03290	COG0363	glucosamine-6-phosphate deaminase activity
I5818_03295	COG2188	Transcriptional regulator
I5818_03320	COG0791	NLP P60 protein
I5818_03320	COG1388	LysM domain
I5818_03325	COG0768	penicillin binding
I5818_03355	COG1309	transcriptional regulator
I5818_03370	COG2153	protein acetylation
I5818_03375	COG0445	tRNA wobble uridine modification
I5818_03380	COG1368	sulfuric ester hydrolase activity
I5818_03385	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_03390	COG1404	Belongs to the peptidase S8 family
I5818_03400	COG1361	Conserved repeat domain
I5818_03400	COG2911	Protein conserved in bacteria
I5818_03400	COG3266	domain, Protein
I5818_03465	COG4974	Belongs to the 'phage' integrase family
I5818_03490	COG0463	Glycosyl transferase, family 2
I5818_03495	COG0463	Glycosyl transferase, family 2
I5818_03495	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5818_03510	COG1063	alcohol dehydrogenase
I5818_03515	COG1082	Xylose isomerase domain protein TIM barrel
I5818_03520	COG1609	Transcriptional regulator
I5818_03525	COG1879	ABC-type sugar transport system periplasmic component
I5818_03530	COG1129	ABC transporter
I5818_03535	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5818_03540	COG0673	inositol 2-dehydrogenase activity
I5818_03575	COG2188	Transcriptional regulator
I5818_03580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_03585	COG1840	ABC-type Fe3 transport system, periplasmic component
I5818_03590	COG3842	ATPase activity
I5818_03595	COG1176	ABC-type spermidine putrescine transport system, permease component I
I5818_03600	COG1177	transmembrane transport
I5818_03615	COG0601	transmembrane transport
I5818_03620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_03625	COG0444	Belongs to the ABC transporter superfamily
I5818_03630	COG4608	Belongs to the ABC transporter superfamily
I5818_03635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_03660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5818_03685	COG1595	DNA-templated transcription, initiation
I5818_03690	COG2972	Histidine kinase
I5818_03695	COG3279	Response regulator of the LytR AlgR family
I5818_03715	COG0395	ABC-type sugar transport system, permease component
I5818_03720	COG0445	tRNA wobble uridine modification
I5818_03725	COG1405	negative regulation of cell septum assembly
I5818_03725	COG3012	SEC-C Motif Domain Protein
I5818_03735	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5818_03745	COG2207	Transcriptional regulator
I5818_03755	COG0756	dUTP diphosphatase activity
I5818_03765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_03770	COG1780	Probably involved in ribonucleotide reductase function
I5818_03785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_03785	COG2213	PTS system mannitol-specific
I5818_03795	COG3775	system Galactitol-specific IIC component
I5818_03800	COG1063	alcohol dehydrogenase
I5818_03810	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5818_03815	COG0561	phosphatase activity
I5818_03820	COG3684	Belongs to the aldolase LacD family
I5818_03825	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_03825	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_03825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_03830	COG1105	Belongs to the carbohydrate kinase PfkB family
I5818_03835	COG1737	Transcriptional regulator
I5818_03845	COG0800	Aldolase
I5818_03850	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I5818_03865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_03870	COG2188	Transcriptional regulator
I5818_03880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5818_03885	COG1012	belongs to the aldehyde dehydrogenase family
I5818_03890	COG1309	transcriptional regulator
I5818_03895	COG2814	Major facilitator Superfamily
I5818_03905	COG4405	Protein conserved in bacteria
I5818_03915	COG1522	sequence-specific DNA binding
I5818_03930	COG0745	RESPONSE REGULATOR receiver
I5818_03935	COG2205	protein histidine kinase activity
I5818_03940	COG1136	(ABC) transporter
I5818_03945	COG0577	efflux transmembrane transporter activity
I5818_03960	COG0584	glycerophosphoryl diester phosphodiesterase
I5818_03965	COG0584	glycerophosphoryl diester phosphodiesterase
I5818_03980	COG1175	transmembrane transport
I5818_03985	COG3842	ATPase activity
I5818_03995	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I5818_04010	COG5298	Protein conserved in bacteria
I5818_04015	COG1215	transferase activity, transferring glycosyl groups
I5818_04025	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I5818_04030	COG1011	Hydrolase
I5818_04035	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I5818_04050	COG0028	Belongs to the TPP enzyme family
I5818_04065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_04095	COG2304	oxidoreductase activity
I5818_04105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I5818_04110	COG1984	allophanate hydrolase subunit 2
I5818_04115	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I5818_04140	COG1396	sequence-specific DNA binding
I5818_04180	COG0601	transmembrane transport
I5818_04190	COG0444	Belongs to the ABC transporter superfamily
I5818_04195	COG4608	Belongs to the ABC transporter superfamily
I5818_04200	COG2204	response regulator
I5818_04205	COG2362	D-Aminopeptidase
I5818_04215	COG0697	spore germination
I5818_04220	COG1522	sequence-specific DNA binding
I5818_04355	COG2222	sugar isomerase
I5818_04360	COG1653	transport
I5818_04365	COG1175	transmembrane transport
I5818_04370	COG0395	ABC-type sugar transport system, permease component
I5818_04375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5818_04380	COG2188	Transcriptional regulator
I5818_04385	COG2234	aminopeptidase activity
I5818_04390	COG1063	alcohol dehydrogenase
I5818_04395	COG1309	transcriptional regulator
I5818_04400	COG1473	amidohydrolase
I5818_04405	COG1473	amidohydrolase
I5818_04410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_04420	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I5818_04425	COG4149	molybdate abc transporter
I5818_04430	COG0725	ABC transporter, periplasmic molybdate-binding protein
I5818_04435	COG1910	domain protein
I5818_04440	COG5564	TIM-barrel signal transduction protein
I5818_04450	COG5564	TIM-barrel signal transduction protein
I5818_04460	COG2084	Dehydrogenase
I5818_04470	COG2610	gluconate transmembrane transporter activity
I5818_04480	COG2271	Major facilitator Superfamily
I5818_04485	COG1473	amidohydrolase
I5818_04490	COG2205	protein histidine kinase activity
I5818_04495	COG1914	H( )-stimulated, divalent metal cation uptake system
I5818_04500	COG1073	alpha beta
I5818_04505	COG1620	l-lactate permease
I5818_04510	COG2186	Transcriptional regulator
I5818_04515	COG0247	lactate metabolic process
I5818_04520	COG1139	Iron-sulfur cluster binding protein
I5818_04525	COG1556	Lactate utilization protein
I5818_04530	COG0601	transmembrane transport
I5818_04535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_04540	COG0444	Belongs to the ABC transporter superfamily
I5818_04545	COG4608	Belongs to the ABC transporter superfamily
I5818_04550	COG4166	transmembrane transport
I5818_04555	COG2362	D-Aminopeptidase
I5818_04560	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5818_04565	COG0531	amino acid
I5818_04585	COG3275	phosphorelay sensor kinase activity
I5818_04590	COG0840	transmembrane signaling receptor activity
I5818_04600	COG2081	HI0933 family
I5818_04615	COG1175	transmembrane transport
I5818_04620	COG0395	ABC-type sugar transport system, permease component
I5818_04630	COG2188	Transcriptional regulator
I5818_04645	COG1473	amidohydrolase
I5818_04650	COG1288	antiporter activity
I5818_04665	COG1388	LysM domain
I5818_04665	COG0791	NLP P60 protein
I5818_04675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_04675	COG1263	PTS System
I5818_04680	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5818_04690	COG2130	NADP-dependent
I5818_04700	COG3711	transcriptional antiterminator
I5818_04700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_04720	COG4821	SIS domain
I5818_04725	COG1414	Transcriptional regulator
I5818_04740	COG2814	Major facilitator Superfamily
I5818_04755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_04760	COG2368	4-hydroxyphenylacetate
I5818_04770	COG2814	Major facilitator Superfamily
I5818_04780	COG0251	oxidation-reduction process
I5818_04810	COG0583	DNA-binding transcription factor activity
I5818_04815	COG3180	Ammonia monooxygenase
I5818_04820	COG3290	protein histidine kinase activity
I5818_04825	COG4565	transcriptional regulatory protein
I5818_04845	COG2079	MmgE PrpD family protein
I5818_04850	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I5818_04855	COG0786	glutamate:sodium symporter activity
I5818_04860	COG0010	Belongs to the arginase family
I5818_04865	COG0583	DNA-binding transcription factor activity
I5818_04875	COG1263	PTS System
I5818_04875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_04875	COG2190	(PTS) system
I5818_04885	COG2190	(PTS) system
I5818_04905	COG1473	amidohydrolase
I5818_04910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I5818_04915	COG0861	Integral membrane protein TerC family
I5818_04920	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_04925	COG1472	Belongs to the glycosyl hydrolase 3 family
I5818_04930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_04940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I5818_04945	COG1234	tRNA 3'-trailer cleavage
I5818_04950	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_04980	COG1131	(ABC) transporter
I5818_05015	COG0561	phosphatase activity
I5818_05020	COG0647	UMP catabolic process
I5818_05025	COG1285	pathogenesis
I5818_05030	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5818_05050	COG1175	transmembrane transport
I5818_05055	COG0395	ABC-type sugar transport system, permease component
I5818_05060	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I5818_05070	COG1737	Transcriptional regulator
I5818_05075	COG1082	Xylose isomerase domain protein TIM barrel
I5818_05090	COG1053	succinate dehydrogenase
I5818_05090	COG3976	FMN-binding domain protein
I5818_05100	COG0673	inositol 2-dehydrogenase activity
I5818_05105	COG0673	inositol 2-dehydrogenase activity
I5818_05110	COG0561	phosphatase activity
I5818_05120	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I5818_05125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_05125	COG1263	PTS System
I5818_05125	COG2190	(PTS) system
I5818_05130	COG2190	(PTS) system
I5818_05140	COG3180	Ammonia monooxygenase
I5818_05145	COG2188	Transcriptional regulator
I5818_05155	COG2222	sugar isomerase
I5818_05160	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_05165	COG3715	PTS system
I5818_05170	COG3716	PTS system mannose fructose sorbose family IID component
I5818_05175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I5818_05180	COG1105	Belongs to the carbohydrate kinase PfkB family
I5818_05185	COG3684	Belongs to the aldolase LacD family
I5818_05195	COG1940	carbohydrate kinase activity
I5818_05205	COG1840	ABC-type Fe3 transport system, periplasmic component
I5818_05210	COG3842	ATPase activity
I5818_05220	COG0165	Argininosuccinate lyase
I5818_05225	COG0385	Bile acid
I5818_05240	COG2723	6-phospho-beta-galactosidase activity
I5818_05250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_05260	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_05265	COG1486	melibiose metabolic process
I5818_05270	COG0084	hydrolase, TatD family'
I5818_05280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5818_05290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5818_05295	COG1122	ATPase activity
I5818_05305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I5818_05320	COG0737	Belongs to the 5'-nucleotidase family
I5818_05335	COG1368	sulfuric ester hydrolase activity
I5818_05345	COG4196	transglutaminase domain protein
I5818_05350	COG1361	Conserved repeat domain
I5818_05355	COG2909	trisaccharide binding
I5818_05365	COG0653	protein targeting
I5818_05370	COG5263	repeat protein
I5818_05370	COG4193	domain, Protein
I5818_05380	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
I5818_05385	COG2244	polysaccharide biosynthetic process
I5818_05400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_05405	COG0840	transmembrane signaling receptor activity
I5818_05420	COG2972	Histidine kinase
I5818_05425	COG4753	response regulator
I5818_05425	COG2207	Transcriptional regulator
I5818_05430	COG2182	Extracellular solute-binding protein
I5818_05435	COG1175	transmembrane transport
I5818_05440	COG0395	ABC-type sugar transport system, permease component
I5818_05450	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_05455	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_05460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_05465	COG3250	beta-galactosidase activity
I5818_05475	COG0523	cobalamin synthesis protein
I5818_05480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5818_05485	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5818_05490	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5818_05495	COG0069	glutamate synthase activity
I5818_05500	COG1309	transcriptional regulator
I5818_05520	COG1846	Transcriptional regulator
I5818_05525	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_05535	COG2205	protein histidine kinase activity
I5818_05540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5818_05560	COG1595	DNA-templated transcription, initiation
I5818_05565	COG1388	LysM domain
I5818_05565	COG3858	chitin binding
I5818_05575	COG0840	transmembrane signaling receptor activity
I5818_05580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5818_05585	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
I5818_05590	COG1595	DNA-templated transcription, initiation
I5818_05610	COG5566	PFAM Mor transcription activator
I5818_05620	COG0753	catalase activity
I5818_05630	COG2814	Major facilitator Superfamily
I5818_05645	COG0456	acetyltransferase
I5818_05650	COG0406	alpha-ribazole phosphatase activity
I5818_05660	COG2318	DinB family
I5818_05665	COG2323	membrane
I5818_05670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_05690	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I5818_05705	COG1131	(ABC) transporter
I5818_05715	COG2197	response regulator
I5818_05735	COG1316	TRANSCRIPTIONal
I5818_05740	COG1739	Uncharacterized protein family UPF0029
I5818_05745	COG4585	Histidine kinase
I5818_05750	COG2197	response regulator
I5818_05760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_05760	COG1263	PTS System
I5818_05765	COG0366	Alpha amylase catalytic
I5818_05770	COG2188	Transcriptional regulator
I5818_05785	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I5818_05790	COG1307	EDD domain protein, DegV family
I5818_05800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5818_05805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5818_05840	COG5582	Belongs to the UPF0302 family
I5818_06105	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I5818_06130	COG1256	bacterial-type flagellum assembly
I5818_06130	COG4786	Flagellar basal body rod
I5818_06135	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5818_06145	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
I5818_06150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I5818_06155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5818_06175	COG2089	acid synthase
I5818_06180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5818_06185	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I5818_06190	COG1516	flagellar protein fliS
I5818_06220	COG1063	alcohol dehydrogenase
I5818_06225	COG4191	Histidine kinase
I5818_06240	COG0840	transmembrane signaling receptor activity
I5818_06245	COG1334	flagellar protein FlaG
I5818_06255	COG0840	transmembrane signaling receptor activity
I5818_06265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_06275	COG1522	sequence-specific DNA binding
I5818_06280	COG0405	Gamma-glutamyltransferase
I5818_06285	COG2059	Chromate
I5818_06290	COG2059	Chromate
I5818_06300	COG0653	protein targeting
I5818_06315	COG2884	Cell division ATP-binding protein ftsE
I5818_06320	COG2177	Part of the ABC transporter FtsEX involved in
I5818_06325	COG3883	PFAM NLP P60 protein
I5818_06325	COG0791	NLP P60 protein
I5818_06335	COG0626	cystathionine gamma-synthase activity
I5818_06340	COG2873	o-acetylhomoserine
I5818_06345	COG0460	homoserine dehydrogenase
I5818_06350	COG0793	Belongs to the peptidase S41A family
I5818_06350	COG3409	Peptidoglycan-binding domain 1 protein
I5818_06355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5818_06365	COG0569	domain protein
I5818_06380	COG0346	lactoylglutathione lyase activity
I5818_06385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_06395	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_06410	COG0431	NADPH-dependent FMN reductase
I5818_06420	COG0745	RESPONSE REGULATOR receiver
I5818_06425	COG5002	protein histidine kinase activity
I5818_06435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I5818_06440	COG0573	inorganic phosphate transmembrane transporter activity
I5818_06445	COG0581	inorganic phosphate transmembrane transporter activity
I5818_06450	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5818_06455	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5818_06460	COG0704	Plays a role in the regulation of phosphate uptake
I5818_06465	COG0640	Transcriptional regulator
I5818_06475	COG1953	Uracil, thiamine, allantoin
I5818_06480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_06485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_06490	COG2508	Transcriptional regulator
I5818_06500	COG2233	PERMEase
I5818_06510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_06515	COG3257	ureidoglycine aminohydrolase activity
I5818_06520	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5818_06525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I5818_06530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5818_06535	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5818_06540	COG0549	Belongs to the carbamate kinase family
I5818_06545	COG0251	oxidation-reduction process
I5818_06550	COG2814	Major facilitator Superfamily
I5818_06560	COG4897	Protein conserved in bacteria
I5818_06565	COG0556	nucleotide-excision repair
I5818_06570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5818_06575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I5818_06580	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5818_06585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I5818_06590	COG1682	transport, permease protein
I5818_06595	COG1134	teichoic acid transport
I5818_06605	COG3595	metallopeptidase activity
I5818_06610	COG1950	PFAM Membrane protein of
I5818_06615	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_06630	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I5818_06640	COG0110	maltose O-acetyltransferase activity
I5818_06645	COG0457	Tetratricopeptide repeat
I5818_06650	COG0492	ferredoxin-NADP+ reductase activity
I5818_06655	COG1051	belongs to the nudix hydrolase family
I5818_06660	COG1660	Displays ATPase and GTPase activities
I5818_06665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I5818_06670	COG1481	regulation of sporulation
I5818_06675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_06680	COG0740	serine-type endopeptidase activity
I5818_06690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I5818_06705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5818_06710	COG0126	phosphoglycerate kinase activity
I5818_06715	COG0149	triose-phosphate isomerase activity
I5818_06720	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
I5818_06725	COG0148	phosphopyruvate hydratase activity
I5818_06730	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I5818_06735	COG1647	Serine aminopeptidase, S33
I5818_06740	COG0557	exoribonuclease II activity
I5818_06745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I5818_06765	COG1053	succinate dehydrogenase
I5818_06780	COG2720	vancomycin resistance protein
I5818_06805	COG1609	Transcriptional regulator
I5818_06810	COG0366	Alpha amylase catalytic
I5818_06815	COG0366	Alpha amylase catalytic
I5818_06820	COG2318	DinB family
I5818_06825	COG2318	DinB family
I5818_06830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5818_06835	COG1937	Protein conserved in bacteria
I5818_06840	COG2608	mercury ion transmembrane transporter activity
I5818_06845	COG2217	Heavy metal translocating P-type atpase
I5818_06855	COG3973	AAA domain
I5818_06865	COG2239	Acts as a magnesium transporter
I5818_06870	COG1309	transcriptional regulator
I5818_06875	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I5818_06890	COG5577	PFAM Coat F domain
I5818_06895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_06900	COG0772	Belongs to the SEDS family
I5818_06935	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_06940	COG0805	protein transport
I5818_06945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_06950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_06955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_06960	COG1120	ATPase activity
I5818_06975	COG0247	lactate metabolic process
I5818_06980	COG0277	FAD linked oxidase domain protein
I5818_06985	COG3835	regulator
I5818_06990	COG5577	PFAM Coat F domain
I5818_07005	COG1024	Enoyl-CoA hydratase
I5818_07005	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_07010	COG0183	Belongs to the thiolase family
I5818_07015	COG1960	acyl-CoA dehydrogenase activity
I5818_07020	COG1393	Belongs to the ArsC family
I5818_07025	COG0509	glycine decarboxylation via glycine cleavage system
I5818_07030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_07045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I5818_07050	COG2011	ABC-type metal ion transport system permease component
I5818_07055	COG1464	Belongs to the NlpA lipoprotein family
I5818_07065	COG0396	ATPase activity
I5818_07070	COG0719	Fe-S assembly protein
I5818_07075	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I5818_07080	COG0822	iron-sulfur transferase activity
I5818_07085	COG0719	Fe-S assembly protein
I5818_07095	COG1801	Protein of unknown function DUF72
I5818_07145	COG0732	type I restriction modification DNA specificity domain
I5818_07190	COG1801	Protein of unknown function DUF72
I5818_07195	COG0737	Belongs to the 5'-nucleotidase family
I5818_07200	COG3377	Domain of unknown function (DUF1805)
I5818_07210	COG0733	neurotransmitter:sodium symporter activity
I5818_07220	COG0739	heme binding
I5818_07230	COG4470	Protein conserved in bacteria
I5818_07240	COG2445	Protein of unknown function DUF86
I5818_07245	COG0647	UMP catabolic process
I5818_07250	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I5818_07255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_07260	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I5818_07265	COG4837	Protein of unknown function (DUF1462)
I5818_07270	COG4844	belongs to the
I5818_07280	COG0316	Belongs to the HesB IscA family
I5818_07290	COG1252	NADH dehydrogenase
I5818_07305	COG3584	3D domain protein
I5818_07310	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
I5818_07325	COG2050	protein possibly involved in aromatic compounds catabolism
I5818_07330	COG2814	Major facilitator Superfamily
I5818_07340	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I5818_07350	COG2032	superoxide dismutase activity
I5818_07355	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5818_07360	COG2267	carboxylic ester hydrolase activity
I5818_07370	COG1098	S1 RNA binding domain
I5818_07375	COG3829	transcription factor binding
I5818_07380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5818_07385	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_07390	COG2155	Conserved Protein
I5818_07405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I5818_07435	COG2801	Transposase and inactivated derivatives
I5818_07440	COG1272	protein, Hemolysin III
I5818_07450	COG2814	Major facilitator Superfamily
I5818_07485	COG1285	pathogenesis
I5818_07490	COG0697	spore germination
I5818_07615	COG1575	Belongs to the MenA family. Type 1 subfamily
I5818_07620	COG1169	isochorismate synthase
I5818_07625	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
I5818_07630	COG0596	Alpha beta hydrolase
I5818_07635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I5818_07640	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_07645	COG4948	Mandelate Racemase Muconate Lactonizing
I5818_07655	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I5818_07665	COG0783	Belongs to the Dps family
I5818_07685	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I5818_07690	COG1116	anion transmembrane transporter activity
I5818_07695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I5818_07700	COG1506	peptidase
I5818_07715	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5818_07720	COG0367	asparagine synthase
I5818_07730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I5818_07735	COG2267	carboxylic ester hydrolase activity
I5818_07745	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I5818_07760	COG2814	Major facilitator Superfamily
I5818_07765	COG0495	leucyl-tRNA aminoacylation
I5818_07775	COG3764	Sortase (surface protein transpeptidase)
I5818_07780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_07790	COG2081	HI0933 family
I5818_07795	COG2244	polysaccharide biosynthetic process
I5818_07805	COG1187	pseudouridine synthase activity
I5818_07810	COG1349	DNA-binding transcription factor activity
I5818_07815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_07835	COG1597	lipid kinase activity
I5818_07840	COG0510	thiamine kinase activity
I5818_07850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I5818_07855	COG1368	sulfuric ester hydrolase activity
I5818_07865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_07870	COG1363	Peptidase, m42
I5818_07875	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I5818_07885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_07890	COG4848	Belongs to the UPF0354 family
I5818_07900	COG1674	ftsk spoiiie
I5818_07905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I5818_07910	COG2309	aminopeptidase activity
I5818_07915	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
I5818_07920	COG4980	gas vesicle protein
I5818_07930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5818_07930	COG1605	Chorismate mutase
I5818_07945	COG0123	including yeast histone deacetylase and acetoin utilization protein
I5818_07950	COG0517	IMP dehydrogenase activity
I5818_07955	COG0454	-acetyltransferase
I5818_07960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5818_07970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I5818_08010	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I5818_08015	COG4632	Exopolysaccharide biosynthesis protein
I5818_08015	COG5434	Belongs to the glycosyl hydrolase 28 family
I5818_08025	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_08030	COG0586	Pfam SNARE associated Golgi protein
I5818_08055	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I5818_08065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I5818_08070	COG2199	diguanylate cyclase activity
I5818_08070	COG2203	Gaf domain
I5818_08075	COG1956	GAF domain-containing protein
I5818_08080	COG1309	transcriptional regulator
I5818_08085	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I5818_08090	COG1104	cysteine desulfurase activity
I5818_08095	COG0301	tRNA thio-modification
I5818_08110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I5818_08115	COG2962	Rard protein
I5818_08120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I5818_08125	COG0616	signal peptide processing
I5818_08130	COG1714	RDD family
I5818_08140	COG3874	Sporulation protein YtfJ
I5818_08145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I5818_08150	COG0827	DNA restriction-modification system
I5818_08155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I5818_08165	COG0521	Mo-molybdopterin cofactor biosynthetic process
I5818_08170	COG0006	proline dipeptidase activity
I5818_08185	COG4109	DRTGG domain
I5818_08195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I5818_08210	COG0587	DNA-directed DNA polymerase activity
I5818_08215	COG0281	malic enzyme
I5818_08220	COG2186	Transcriptional regulator
I5818_08225	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I5818_08230	COG0825	malonyl-CoA metabolic process
I5818_08235	COG0205	6-phosphofructokinase activity
I5818_08245	COG0628	permease
I5818_08250	COG0372	Belongs to the citrate synthase family
I5818_08255	COG0538	isocitrate dehydrogenase activity
I5818_08260	COG0039	L-malate dehydrogenase activity
I5818_08270	COG0330	HflC and HflK could
I5818_08275	COG0330	HflC and HflK could
I5818_08280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_08280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_08285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5818_08290	COG1971	Probably functions as a manganese efflux pump
I5818_08300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I5818_08305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I5818_08310	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I5818_08315	COG3611	Membrane attachment protein
I5818_08320	COG1484	DNA-dependent DNA replication
I5818_08330	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5818_08335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I5818_08340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I5818_08345	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I5818_08355	COG0398	Pfam SNARE associated Golgi protein
I5818_08365	COG1363	Peptidase, m42
I5818_08375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I5818_08380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I5818_08390	COG0670	Belongs to the BI1 family
I5818_08400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
I5818_08405	COG1286	toxin biosynthetic process
I5818_08410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I5818_08410	COG1796	DNA polymerase
I5818_08415	COG1193	negative regulation of DNA recombination
I5818_08420	COG3766	membrane
I5818_08425	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_08430	COG1309	transcriptional regulator
I5818_08435	COG1024	Enoyl-CoA hydratase
I5818_08440	COG2086	electron transfer activity
I5818_08445	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I5818_08450	COG3336	cytochrome c oxidase
I5818_08455	COG2217	Heavy metal translocating P-type atpase
I5818_08460	COG3118	belongs to the thioredoxin family
I5818_08465	COG0322	excinuclease ABC activity
I5818_08475	COG1719	4-vinyl reductase, 4VR
I5818_08480	COG2009	succinate dehydrogenase
I5818_08485	COG1053	succinate dehydrogenase
I5818_08490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I5818_08495	COG0824	Thioesterase
I5818_08500	COG2197	response regulator
I5818_08505	COG1846	Transcriptional regulator
I5818_08515	COG5401	PFAM Sporulation and spore germination
I5818_08520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I5818_08530	COG0622	Phosphoesterase
I5818_08540	COG0457	Tetratricopeptide repeat
I5818_08540	COG1477	protein flavinylation
I5818_08545	COG0544	peptidyl-prolyl cis-trans isomerase activity
I5818_08550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I5818_08560	COG1067	ATP-dependent peptidase activity
I5818_08560	COG0470	DNA polymerase III
I5818_08565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I5818_08570	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I5818_08585	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5818_08590	COG0181	hydroxymethylbilane synthase activity
I5818_08600	COG0113	porphobilinogen synthase activity
I5818_08605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5818_08610	COG1388	LysM domain
I5818_08610	COG1388	LysM domain
I5818_08615	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_08625	COG0525	valine-tRNA ligase activity
I5818_08630	COG0285	dihydrofolate synthase activity
I5818_08640	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I5818_08650	COG0424	maF-like protein
I5818_08655	COG2003	Belongs to the UPF0758 family
I5818_08660	COG1077	Cell shape determining protein MreB Mrl
I5818_08665	COG1792	Involved in formation and maintenance of cell shape
I5818_08670	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I5818_08675	COG0850	regulation of cytokinetic process
I5818_08680	COG2894	cell division
I5818_08685	COG0739	heme binding
I5818_08690	COG1994	Peptidase M50
I5818_08700	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I5818_08705	COG2868	ribosomal protein
I5818_08710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I5818_08715	COG3290	protein histidine kinase activity
I5818_08720	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I5818_08725	COG4492	Belongs to the UPF0735 family
I5818_08730	COG0077	Prephenate dehydratase
I5818_08735	COG1827	regulation of RNA biosynthetic process
I5818_08740	COG1388	LysM domain
I5818_08760	COG0632	four-way junction helicase activity
I5818_08770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I5818_08780	COG1862	Preprotein translocase
I5818_08790	COG2323	membrane
I5818_08795	COG2244	polysaccharide biosynthetic process
I5818_08805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5818_08805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I5818_08810	COG0300	oxidoreductase activity
I5818_08825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I5818_08825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I5818_08830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I5818_08835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I5818_08845	COG4991	sh3 domain protein
I5818_08845	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_08845	COG3103	Sh3 type 3 domain protein
I5818_08855	COG0124	histidyl-tRNA synthetase
I5818_08860	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I5818_08870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I5818_08880	COG1725	Transcriptional regulator
I5818_08885	COG1131	(ABC) transporter
I5818_08890	COG1131	(ABC) transporter
I5818_08895	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5818_08900	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I5818_08905	COG1959	2 iron, 2 sulfur cluster binding
I5818_08910	COG1104	cysteine desulfurase activity
I5818_08925	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5818_08950	COG0628	permease
I5818_08960	COG4472	Bacterial protein of unknown function (DUF965)
I5818_08970	COG3906	Belongs to the UPF0473 family
I5818_08980	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I5818_08985	COG4122	O-methyltransferase activity
I5818_08990	COG0572	uridine kinase
I5818_08995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I5818_09000	COG0768	penicillin binding
I5818_09015	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I5818_09025	COG1566	PFAM secretion protein HlyD family protein
I5818_09030	COG2814	Major facilitator Superfamily
I5818_09055	COG1183	phosphatidylcholine synthase activity
I5818_09060	COG0688	phosphatidylethanolamine metabolic process
I5818_09070	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I5818_09075	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5818_09085	COG1534	Rna-binding protein
I5818_09090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5818_09095	COG1713	HD superfamily hydrolase involved in NAD metabolism
I5818_09100	COG0799	negative regulation of ribosome biogenesis
I5818_09105	COG2226	methyltransferase
I5818_09110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5818_09115	COG1555	photosystem II stabilization
I5818_09115	COG1596	polysaccharide export
I5818_09120	COG2131	deaminase
I5818_09125	COG2333	competence protein COMEC
I5818_09125	COG0658	competence protein
I5818_09135	COG1466	dna polymerase III delta subunit
I5818_09140	COG0268	Binds directly to 16S ribosomal RNA
I5818_09150	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_09160	COG0481	GTPase activity
I5818_09165	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I5818_09170	COG1420	regulation of RNA biosynthetic process
I5818_09175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I5818_09180	COG0443	Heat shock 70 kDa protein
I5818_09190	COG2264	protein methyltransferase activity
I5818_09195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I5818_09200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5818_09205	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I5818_09210	COG1283	sodium-dependent phosphate transmembrane transporter activity
I5818_09215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I5818_09220	COG1610	YqeY-like protein
I5818_09225	COG1030	water channel activity
I5818_09230	COG4864	UPF0365 protein
I5818_09250	COG1702	phosphate starvation-inducible protein PhoH
I5818_09255	COG1480	7TM receptor with intracellular HD hydrolase
I5818_09265	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I5818_09270	COG0295	cytidine deaminase activity
I5818_09275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I5818_09285	COG1381	Involved in DNA repair and RecF pathway recombination
I5818_09290	COG0517	IMP dehydrogenase activity
I5818_09300	COG1671	Belongs to the UPF0178 family
I5818_09305	COG0358	DNA primase activity
I5818_09310	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I5818_09320	COG1960	acyl-CoA dehydrogenase activity
I5818_09325	COG2010	Cytochrome c
I5818_09330	COG2384	SAM-dependent methyltransferase
I5818_09335	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I5818_09340	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I5818_09350	COG0513	Belongs to the DEAD box helicase family
I5818_09355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I5818_09365	COG0735	belongs to the Fur family
I5818_09370	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
I5818_09375	COG4709	membrane
I5818_09380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I5818_09390	COG5521	maltodextrose utilization protein MalA
I5818_09400	COG0477	Major facilitator Superfamily
I5818_09405	COG0768	penicillin binding
I5818_09410	COG0768	penicillin binding
I5818_09430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I5818_09435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I5818_09445	COG0705	Rhomboid family
I5818_09445	COG0457	Tetratricopeptide repeat
I5818_09455	COG4483	Protein conserved in bacteria
I5818_09460	COG1940	carbohydrate kinase activity
I5818_09465	COG1368	sulfuric ester hydrolase activity
I5818_09480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_09490	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I5818_09495	COG1459	type II secretion system
I5818_09500	COG4537	Required for transformation and DNA binding
I5818_09540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5818_09545	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I5818_09550	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_09555	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I5818_09560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_09565	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_09575	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5818_09585	COG3872	metal-dependent enzyme
I5818_09595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I5818_09600	COG0006	proline dipeptidase activity
I5818_09605	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I5818_09610	COG3854	ATPases associated with a variety of cellular activities
I5818_09650	COG0511	ligase activity, forming carbon-carbon bonds
I5818_09655	COG0439	Biotin carboxylase
I5818_09660	COG1302	Protein conserved in bacteria
I5818_09685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I5818_09690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I5818_09700	COG0497	DNA recombination
I5818_09705	COG0750	zinc metalloprotease
I5818_09720	COG0584	glycerophosphoryl diester phosphodiesterase
I5818_09735	COG3829	transcription factor binding
I5818_09735	COG3290	protein histidine kinase activity
I5818_09740	COG0280	phosphate acetyltransferase
I5818_09750	COG3426	butyrate kinase activity
I5818_09755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I5818_09760	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I5818_09765	COG0022	dehydrogenase e1 component
I5818_09770	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5818_09775	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_09780	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_09780	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_09785	COG1703	isobutyryl-CoA mutase activity
I5818_09800	COG0346	lactoylglutathione lyase activity
I5818_09805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5818_09815	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5818_09820	COG0835	chemotaxis
I5818_09820	COG0784	Response regulator, receiver
I5818_09830	COG5506	Protein of unknown function (DUF1694)
I5818_09835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I5818_09840	COG1234	tRNA 3'-trailer cleavage
I5818_09845	COG1902	pentaerythritol trinitrate reductase activity
I5818_09850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I5818_09855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_09860	COG0300	oxidoreductase activity
I5818_09865	COG1473	amidohydrolase
I5818_09870	COG1757	Na H antiporter
I5818_09905	COG0109	protoheme IX farnesyltransferase activity
I5818_09910	COG0656	L-ascorbic acid biosynthetic process
I5818_09920	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_09945	COG1073	alpha beta
I5818_09950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5818_09955	COG3853	Toxic anion resistance protein (TelA)
I5818_09960	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
I5818_09970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I5818_09975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I5818_09995	COG0667	Aldo Keto reductase
I5818_10010	COG1379	DNA repair
I5818_10020	COG1300	Membrane
I5818_10025	COG0735	belongs to the Fur family
I5818_10035	COG4974	Belongs to the 'phage' integrase family
I5818_10055	COG1686	Belongs to the peptidase S11 family
I5818_10090	COG0697	spore germination
I5818_10105	COG1547	Domain of unknown function (DUF309)
I5818_10120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I5818_10125	COG1686	Belongs to the peptidase S11 family
I5818_10130	COG2715	membrane protein required for spore maturation
I5818_10135	COG0700	Nucleoside recognition
I5818_10140	COG1187	pseudouridine synthase activity
I5818_10145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_10150	COG1333	cytochrome c biogenesis protein
I5818_10155	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5818_10160	COG0745	RESPONSE REGULATOR receiver
I5818_10165	COG5002	protein histidine kinase activity
I5818_10170	COG1595	DNA-templated transcription, initiation
I5818_10180	COG0739	heme binding
I5818_10185	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I5818_10190	COG1141	Ferredoxin
I5818_10195	COG4955	Helix-turn-helix domain
I5818_10200	COG0514	ATP-dependent DNA helicase (RecQ)
I5818_10205	COG1266	CAAX protease self-immunity
I5818_10220	COG3546	catalase activity
I5818_10240	COG1408	metallophosphoesterase
I5818_10250	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_10255	COG0492	ferredoxin-NADP+ reductase activity
I5818_10260	COG0252	asparaginase activity
I5818_10265	COG2339	peptidase activity
I5818_10270	COG3773	Cell wall hydrolase
I5818_10270	COG3409	Peptidoglycan-binding domain 1 protein
I5818_10275	COG2959	enzyme of heme biosynthesis
I5818_10290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I5818_10300	COG0539	negative regulation of cytoplasmic translation
I5818_10320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I5818_10335	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5818_10345	COG0302	gtp cyclohydrolase
I5818_10350	COG0142	geranyltranstransferase activity
I5818_10355	COG2226	methyltransferase
I5818_10360	COG0142	geranyltranstransferase activity
I5818_10365	COG0105	UTP biosynthetic process
I5818_10370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I5818_10380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5818_10385	COG4401	Chorismate mutase type I
I5818_10390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5818_10395	COG0287	Prephenate dehydrogenase
I5818_10400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I5818_10410	COG0457	Tetratricopeptide repeat
I5818_10415	COG5582	Belongs to the UPF0302 family
I5818_10430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I5818_10440	COG4347	Protein of unknown function (DUF1405)
I5818_10450	COG2738	Putative neutral zinc metallopeptidase
I5818_10455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_10460	COG1694	Mazg nucleotide pyrophosphohydrolase
I5818_10465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I5818_10470	COG1803	Methylglyoxal synthase
I5818_10475	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5818_10480	COG0438	transferase activity, transferring glycosyl groups
I5818_10485	COG0617	tRNA 3'-terminal CCA addition
I5818_10495	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I5818_10500	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I5818_10505	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
I5818_10510	COG1199	ATP-dependent helicase activity
I5818_10510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I5818_10525	COG0436	Aminotransferase
I5818_10530	COG0017	Asparaginyl-tRNA synthetase
I5818_10535	COG3935	DnaD domain protein
I5818_10540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I5818_10545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5818_10545	COG4499	WXG100 protein secretion system (Wss), protein YukC
I5818_10575	COG1111	helicase
I5818_10575	COG1205	dead DEAH box helicase
I5818_10580	COG3359	exonuclease
I5818_10605	COG0116	Belongs to the methyltransferase superfamily
I5818_10615	COG1199	ATP-dependent helicase activity
I5818_10620	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I5818_10630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5818_10635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5818_10650	COG2233	PERMEase
I5818_10655	COG1476	TRANSCRIPTIONal
I5818_10680	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_10690	COG3424	synthase
I5818_10695	COG1755	Isoprenylcysteine carboxyl methyltransferase
I5818_10700	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I5818_10715	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_10735	COG0328	RNA-DNA hybrid ribonuclease activity
I5818_10740	COG0328	RNA-DNA hybrid ribonuclease activity
I5818_10755	COG1321	iron dependent repressor
I5818_10760	COG2226	methyltransferase
I5818_10800	COG1418	mRNA catabolic process
I5818_10805	COG0488	(ABC) transporter
I5818_10810	COG1413	lyase activity
I5818_10820	COG2521	methyltransferase
I5818_10820	COG2136	Putative SAM-dependent methyltransferase
I5818_10835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I5818_10840	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5818_10845	COG1272	protein, Hemolysin III
I5818_10875	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5818_10885	COG0840	transmembrane signaling receptor activity
I5818_10890	COG4479	Belongs to the UPF0346 family
I5818_10920	COG1876	peptidase activity
I5818_10925	COG3409	Peptidoglycan-binding domain 1 protein
I5818_10925	COG0793	Belongs to the peptidase S41A family
I5818_10940	COG2340	Cysteine-rich secretory protein family
I5818_10960	COG0586	Pfam SNARE associated Golgi protein
I5818_10980	COG1131	(ABC) transporter
I5818_11000	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
I5818_11005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I5818_11010	COG1793	dna ligase
I5818_11010	COG3285	dna ligase
I5818_11015	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
I5818_11020	COG0671	phosphoesterase, PA-phosphatase related
I5818_11030	COG1278	Cold shock
I5818_11035	COG1368	sulfuric ester hydrolase activity
I5818_11040	COG1280	lysine exporter protein (LysE YggA)
I5818_11055	COG1113	amino acid transport
I5818_11070	COG2814	Major facilitator Superfamily
I5818_11100	COG0596	Alpha beta hydrolase
I5818_11110	COG4145	pantothenate transmembrane transporter activity
I5818_11115	COG2258	MOSC domain
I5818_11120	COG0444	Belongs to the ABC transporter superfamily
I5818_11125	COG4608	Belongs to the ABC transporter superfamily
I5818_11130	COG0747	negative chemotaxis
I5818_11135	COG0601	transmembrane transport
I5818_11140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_11145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_11150	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I5818_11160	COG0745	RESPONSE REGULATOR receiver
I5818_11165	COG5002	protein histidine kinase activity
I5818_11175	COG0567	Dehydrogenase, E1 component
I5818_11180	COG0508	dehydrogenase complex catalyzes the overall conversion of
I5818_11195	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_11200	COG1012	belongs to the aldehyde dehydrogenase family
I5818_11220	COG0714	Associated with various cellular activities
I5818_11225	COG4548	von Willebrand factor, type A
I5818_11235	COG1686	Belongs to the peptidase S11 family
I5818_11240	COG2181	nitrate reductase activity
I5818_11245	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I5818_11250	COG1140	nitrate reductase beta subunit
I5818_11255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I5818_11260	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5818_11265	COG2223	nitrite transmembrane transporter activity
I5818_11270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I5818_11275	COG0303	'Molybdopterin
I5818_11280	COG1763	Mo-molybdopterin cofactor biosynthetic process
I5818_11305	COG2223	nitrite transmembrane transporter activity
I5818_11320	COG0392	lysyltransferase activity
I5818_11320	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I5818_11325	COG1054	Belongs to the UPF0176 family
I5818_11330	COG0392	lysyltransferase activity
I5818_11330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I5818_11335	COG1164	Oligoendopeptidase f
I5818_11350	COG2323	membrane
I5818_11355	COG2368	4-hydroxyphenylacetate
I5818_11360	COG0488	(ABC) transporter
I5818_11375	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_11375	COG0723	plastoquinol--plastocyanin reductase activity
I5818_11380	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
I5818_11390	COG3594	Acyltransferase
I5818_11395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_11400	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I5818_11405	COG0730	response to heat
I5818_11420	COG2814	Major facilitator Superfamily
I5818_11430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5818_11440	COG0463	Glycosyl transferase, family 2
I5818_11455	COG1809	phosphosulfolactate synthase activity
I5818_11465	COG0175	sulfate reduction
I5818_11470	COG2046	Belongs to the sulfate adenylyltransferase family
I5818_11475	COG0529	Catalyzes the synthesis of activated sulfate
I5818_11480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_11490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5818_11500	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5818_11505	COG1121	(ABC) transporter
I5818_11510	COG1321	iron dependent repressor
I5818_11510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5818_11515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5818_11540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I5818_11545	COG0131	Imidazoleglycerol-phosphate dehydratase
I5818_11550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I5818_11560	COG0107	imidazoleglycerol-phosphate synthase activity
I5818_11565	COG0140	phosphoribosyl-ATP diphosphatase activity
I5818_11565	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I5818_11585	COG0697	spore germination
I5818_11600	COG0673	inositol 2-dehydrogenase activity
I5818_11605	COG0494	nUDIX hydrolase
I5818_11610	COG0803	Belongs to the bacterial solute-binding protein 9 family
I5818_11615	COG1121	(ABC) transporter
I5818_11620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I5818_11625	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I5818_11630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_11665	COG2217	Heavy metal translocating P-type atpase
I5818_11670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I5818_11685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5818_11700	COG1278	Cold shock
I5818_11725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_11730	COG0697	spore germination
I5818_11760	COG0693	protein deglycase activity
I5818_11765	COG2378	regulation of single-species biofilm formation
I5818_11790	COG1605	Chorismate mutase
I5818_11790	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5818_11800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
I5818_11805	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5818_11810	COG0287	Prephenate dehydrogenase
I5818_11835	COG1271	oxidase subunit
I5818_11840	COG1294	oxidase, subunit
I5818_11870	COG0488	(ABC) transporter
I5818_11890	COG0494	nUDIX hydrolase
I5818_11895	COG1335	isochorismatase
I5818_11900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5818_11905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I5818_11910	COG2733	membrane
I5818_11915	COG3647	Membrane
I5818_11935	COG2124	cytochrome p450
I5818_11940	COG1247	-acetyltransferase
I5818_11950	COG1051	belongs to the nudix hydrolase family
I5818_11950	COG1056	cytidyltransferase-related domain
I5818_11955	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5818_11960	COG1595	DNA-templated transcription, initiation
I5818_11970	COG0772	Belongs to the SEDS family
I5818_12055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I5818_12070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I5818_12105	COG1595	DNA-templated transcription, initiation
I5818_12125	COG1131	(ABC) transporter
I5818_12130	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5818_12135	COG1131	(ABC) transporter
I5818_12195	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I5818_12200	COG1193	negative regulation of DNA recombination
I5818_12205	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I5818_12210	COG0598	Magnesium transport protein CorA
I5818_12245	COG1725	Transcriptional regulator
I5818_12250	COG1131	(ABC) transporter
I5818_12270	COG3773	Cell wall hydrolase
I5818_12275	COG5577	PFAM Coat F domain
I5818_12295	COG0708	Exodeoxyribonuclease III
I5818_12300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I5818_12310	COG0488	(ABC) transporter
I5818_12335	COG1609	Transcriptional regulator
I5818_12345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5818_12350	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I5818_12375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I5818_12405	COG3852	Histidine kinase
I5818_12410	COG0656	L-ascorbic acid biosynthetic process
I5818_12415	COG4555	ABC transporter
I5818_12430	COG2072	flavoprotein involved in K transport
I5818_12435	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_12440	COG0657	acetylesterase activity
I5818_12465	COG0768	penicillin binding
I5818_12470	COG0768	penicillin binding
I5818_12490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_12495	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I5818_12500	COG0187	DNA topoisomerase II activity
I5818_12505	COG1832	CoA-binding protein
I5818_12510	COG2233	PERMEase
I5818_12515	COG3858	chitin binding
I5818_12520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I5818_12525	COG2843	Capsule synthesis protein
I5818_12530	COG4841	protein insertion into membrane
I5818_12540	COG0824	Thioesterase
I5818_12560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I5818_12565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I5818_12570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_12590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I5818_12595	COG0739	heme binding
I5818_12600	COG1346	cytolysis
I5818_12605	COG1380	Effector of murein hydrolase LrgA
I5818_12610	COG2427	Protein of unknown function (DUF1641)
I5818_12615	COG1510	regulation of RNA biosynthetic process
I5818_12620	COG0517	IMP dehydrogenase activity
I5818_12620	COG4175	Glycine betaine
I5818_12625	COG4176	ABC-type proline glycine betaine transport system permease component
I5818_12630	COG2113	Glycine betaine
I5818_12645	COG3314	Sporulation integral membrane protein YlbJ
I5818_12650	COG1228	amidohydrolase
I5818_12655	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I5818_12660	COG3162	membrane
I5818_12665	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_12670	COG0312	modulator of DNA gyrase
I5818_12675	COG0312	modulator of DNA gyrase
I5818_12680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_12680	COG2207	Transcriptional regulator
I5818_12685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_12690	COG1619	proteins homologs of microcin C7 resistance protein MccF
I5818_12700	COG2030	dehydratase
I5818_12705	COG1914	H( )-stimulated, divalent metal cation uptake system
I5818_12710	COG1473	amidohydrolase
I5818_12720	COG0840	transmembrane signaling receptor activity
I5818_12725	COG1012	belongs to the aldehyde dehydrogenase family
I5818_12735	COG0386	Belongs to the glutathione peroxidase family
I5818_12740	COG0783	Belongs to the Dps family
I5818_12770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_12785	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I5818_12790	COG0709	Synthesizes selenophosphate from selenide and ATP
I5818_12795	COG0701	Predicted permease
I5818_12805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I5818_12820	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I5818_12830	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I5818_12845	COG0438	transferase activity, transferring glycosyl groups
I5818_12850	COG1132	(ABC) transporter
I5818_12855	COG1216	Glycosyl transferase, family 2
I5818_12855	COG1442	glycosyl transferase family 8
I5818_12880	COG1086	Polysaccharide biosynthesis protein
I5818_12890	COG4464	protein tyrosine phosphatase activity
I5818_12895	COG0489	protein tyrosine kinase activity
I5818_12900	COG3944	biosynthesis protein
I5818_12915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I5818_12920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I5818_12950	COG0477	Major facilitator Superfamily
I5818_12955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I5818_12960	COG0733	neurotransmitter:sodium symporter activity
I5818_12990	COG3239	Fatty acid desaturase
I5818_12995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I5818_13005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_13010	COG0322	excinuclease ABC activity
I5818_13015	COG1879	ABC-type sugar transport system periplasmic component
I5818_13020	COG1172	Belongs to the binding-protein-dependent transport system permease family
I5818_13025	COG1129	ABC transporter
I5818_13035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I5818_13040	COG1609	Transcriptional regulator
I5818_13050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I5818_13055	COG1012	belongs to the aldehyde dehydrogenase family
I5818_13060	COG2508	Transcriptional regulator
I5818_13090	COG0697	spore germination
I5818_13115	COG0493	'glutamate synthase
I5818_13200	COG1595	DNA-templated transcription, initiation
I5818_13210	COG5001	Diguanylate cyclase
I5818_13220	COG1309	transcriptional regulator
I5818_13225	COG0477	Major facilitator Superfamily
I5818_13240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5818_13250	COG0716	FMN binding
I5818_13285	COG1506	peptidase
I5818_13295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I5818_13300	COG0436	Aminotransferase
I5818_13310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_13355	COG1115	amino acid carrier protein
I5818_13360	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I5818_13365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5818_13370	COG0778	Nitroreductase
I5818_13390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5818_13405	COG1304	FMN binding
I5818_13420	COG0010	Belongs to the arginase family
I5818_13430	COG2814	Major facilitator Superfamily
I5818_13440	COG1346	cytolysis
I5818_13445	COG1380	Effector of murein hydrolase LrgA
I5818_13450	COG1846	Transcriptional regulator
I5818_13500	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I5818_13520	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5818_13525	COG0352	thiamine-phosphate diphosphorylase activity
I5818_13530	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
I5818_13535	COG0352	thiamine-phosphate diphosphorylase activity
I5818_13535	COG0351	phosphomethylpyrimidine kinase
I5818_13560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5818_13570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5818_13575	COG2315	Protein conserved in bacteria
I5818_13590	COG0582	viral genome integration into host DNA
I5818_13595	COG0490	domain, Protein
I5818_13600	COG0475	glutathione-regulated potassium exporter activity
I5818_13655	COG0456	acetyltransferase
I5818_13655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I5818_13680	COG2816	NAD+ diphosphatase activity
I5818_13705	COG1396	sequence-specific DNA binding
I5818_13715	COG4608	Belongs to the ABC transporter superfamily
I5818_13720	COG0444	Belongs to the ABC transporter superfamily
I5818_13725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_13730	COG0601	transmembrane transport
I5818_13735	COG0747	negative chemotaxis
I5818_13740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I5818_13745	COG0492	ferredoxin-NADP+ reductase activity
I5818_13750	COG1120	ATPase activity
I5818_13755	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_13760	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_13765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_13770	COG2252	PERMEase
I5818_13775	COG3711	transcriptional antiterminator
I5818_13775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_13785	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_13790	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_13795	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_13800	COG1486	melibiose metabolic process
I5818_13805	COG3663	DNA glycosylase
I5818_13825	COG0534	Mate efflux family protein
I5818_13840	COG0346	lactoylglutathione lyase activity
I5818_13845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_13850	COG0006	proline dipeptidase activity
I5818_13855	COG3428	Bacterial PH domain
I5818_13920	COG1357	PFAM Pentapeptide repeats (8 copies)
I5818_13925	COG0500	methyltransferase
I5818_13945	COG1725	Transcriptional regulator
I5818_13950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5818_13980	COG2372	response to copper ion
I5818_13985	COG1349	DNA-binding transcription factor activity
I5818_13990	COG1115	amino acid carrier protein
I5818_14020	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_14035	COG0406	alpha-ribazole phosphatase activity
I5818_14070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I5818_14080	COG0456	acetyltransferase
I5818_14115	COG0406	alpha-ribazole phosphatase activity
I5818_14135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I5818_14150	COG2329	Antibiotic biosynthesis monooxygenase
I5818_14160	COG1794	racemase activity, acting on amino acids and derivatives
I5818_14170	COG5566	PFAM Mor transcription activator
I5818_14190	COG1012	belongs to the aldehyde dehydrogenase family
I5818_14205	COG2323	membrane
I5818_14220	COG0477	Major facilitator Superfamily
I5818_14250	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
I5818_14255	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_14260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5818_14265	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_14285	COG2226	methyltransferase
I5818_14320	COG2318	DinB family
I5818_14330	COG4106	trans-aconitate 2-methyltransferase activity
I5818_14370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I5818_14390	COG0456	acetyltransferase
I5818_14400	COG1335	isochorismatase
I5818_14405	COG0697	spore germination
I5818_14410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_14425	COG2271	Major facilitator Superfamily
I5818_14435	COG3420	alginic acid biosynthetic process
I5818_14455	COG0745	RESPONSE REGULATOR receiver
I5818_14460	COG2205	protein histidine kinase activity
I5818_14490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_14505	COG0456	acetyltransferase
I5818_14525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I5818_14530	COG1268	BioY protein
I5818_14535	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_14540	COG0183	Belongs to the thiolase family
I5818_14570	COG1525	nuclease
I5818_14590	COG3655	Transcriptional regulator
I5818_14610	COG3541	Predicted nucleotidyltransferase
I5818_14615	COG0431	NADPH-dependent FMN reductase
I5818_14645	COG0673	inositol 2-dehydrogenase activity
I5818_14650	COG1051	belongs to the nudix hydrolase family
I5818_14680	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I5818_14690	COG1732	Glycine betaine
I5818_14695	COG1174	glycine betaine transport
I5818_14700	COG0517	IMP dehydrogenase activity
I5818_14700	COG1125	glycine betaine transport
I5818_14705	COG1510	regulation of RNA biosynthetic process
I5818_14710	COG3011	Protein conserved in bacteria
I5818_14715	COG1607	acyl-coa hydrolase
I5818_14720	COG1285	pathogenesis
I5818_14725	COG2814	Major facilitator Superfamily
I5818_14730	COG0583	DNA-binding transcription factor activity
I5818_14760	COG2814	Major facilitator Superfamily
I5818_14765	COG2814	Major facilitator Superfamily
I5818_14775	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I5818_14785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I5818_14795	COG1136	(ABC) transporter
I5818_14800	COG0577	efflux transmembrane transporter activity
I5818_14820	COG2271	Major facilitator Superfamily
I5818_14825	COG0277	FAD linked oxidase domain protein
I5818_14830	COG2066	Belongs to the glutaminase family
I5818_14840	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5818_14865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5818_14870	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5818_14870	COG0512	Glutamine amidotransferase of anthranilate synthase
I5818_14880	COG2226	methyltransferase
I5818_14895	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_14915	COG1396	sequence-specific DNA binding
I5818_14925	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_14930	COG2211	Major facilitator Superfamily
I5818_14950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5818_14960	COG0165	Argininosuccinate lyase
I5818_14965	COG0137	argininosuccinate synthase activity
I5818_14970	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I5818_14980	COG0505	Belongs to the CarA family
I5818_14985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I5818_14990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I5818_14995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I5818_15000	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I5818_15025	COG2226	methyltransferase
I5818_15030	COG0601	transmembrane transport
I5818_15060	COG0419	ATPase involved in DNA repair
I5818_15065	COG0420	3'-5' exonuclease activity
I5818_15070	COG0204	Acyl-transferase
I5818_15090	COG4846	Membrane protein involved in cytochrome C biogenesis
I5818_15095	COG2201	protein-glutamate methylesterase activity
I5818_15100	COG0785	Cytochrome C biogenesis protein
I5818_15110	COG1132	(ABC) transporter
I5818_15115	COG1132	(ABC) transporter
I5818_15130	COG1595	DNA-templated transcription, initiation
I5818_15140	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5818_15150	COG1999	signal sequence binding
I5818_15180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5818_15185	COG1388	LysM domain
I5818_15190	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I5818_15205	COG3409	Peptidoglycan-binding domain 1 protein
I5818_15205	COG5632	N-Acetylmuramoyl-L-alanine amidase
I5818_15260	COG0174	glutamine synthetase
I5818_15265	COG0789	Transcriptional regulator
I5818_15270	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I5818_15275	COG2860	membrane
I5818_15280	COG0464	growth
I5818_15285	COG1923	regulation of RNA biosynthetic process
I5818_15290	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I5818_15310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_15315	COG2076	Multidrug Resistance protein
I5818_15320	COG2076	Multidrug Resistance protein
I5818_15340	COG1705	Flagellar rod assembly protein muramidase FlgJ
I5818_15385	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I5818_15390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I5818_15400	COG4550	Control of competence regulator ComK, YlbF/YmcA
I5818_15405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I5818_15410	COG2359	stage V sporulation protein S
I5818_15415	COG1692	metallophosphoesterase
I5818_15430	COG1058	Belongs to the CinA family
I5818_15430	COG1546	Belongs to the CinA family
I5818_15435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I5818_15440	COG1426	Protein conserved in bacteria
I5818_15455	COG0300	oxidoreductase activity
I5818_15460	COG0612	Peptidase, M16
I5818_15465	COG0612	Peptidase, M16
I5818_15470	COG1079	Belongs to the binding-protein-dependent transport system permease family
I5818_15475	COG4603	Belongs to the binding-protein-dependent transport system permease family
I5818_15480	COG3845	ABC transporter
I5818_15485	COG1744	ABC transporter substrate-binding protein PnrA-like
I5818_15490	COG2188	Transcriptional regulator
I5818_15495	COG1674	ftsk spoiiie
I5818_15495	COG4980	gas vesicle protein
I5818_15505	COG0740	serine-type endopeptidase activity
I5818_15515	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5818_15520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5818_15535	COG0527	aspartate kinase activity
I5818_15540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I5818_15545	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5818_15550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I5818_15555	COG1873	PFAM PRC-barrel domain
I5818_15560	COG0612	Peptidase, M16
I5818_15565	COG0726	polysaccharide deacetylase
I5818_15570	COG1185	polyribonucleotide nucleotidyltransferase activity
I5818_15575	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I5818_15580	COG0196	riboflavin kinase activity
I5818_15585	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I5818_15590	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I5818_15595	COG1550	Protein conserved in bacteria
I5818_15600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I5818_15605	COG1358	cellular component organization or biogenesis
I5818_15610	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I5818_15615	COG0195	Participates in both transcription termination and antitermination
I5818_15620	COG0779	Required for maturation of 30S ribosomal subunits
I5818_15625	COG2176	DNA-directed DNA polymerase activity
I5818_15630	COG0750	zinc metalloprotease
I5818_15635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I5818_15640	COG4589	Belongs to the CDS family
I5818_15650	COG0233	cytoplasmic translational termination
I5818_15655	COG0528	UMP kinase activity
I5818_15680	COG1191	sigma factor activity
I5818_15685	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
I5818_15690	COG1776	CheC inhibitor of MCP methylation
I5818_15695	COG0835	chemotaxis
I5818_15700	COG2198	Histidine kinase
I5818_15700	COG0643	Histidine kinase
I5818_15705	COG2201	protein-glutamate methylesterase activity
I5818_15710	COG0455	bacterial-type flagellum organization
I5818_15715	COG1419	protein localization to endoplasmic reticulum
I5818_15720	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5818_15725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I5818_15730	COG1684	flagellar biosynthetic protein fliR
I5818_15735	COG1987	bacterial-type flagellum assembly
I5818_15740	COG1338	Plays a role in the flagellum-specific transport system
I5818_15745	COG3190	flagellar
I5818_15750	COG2201	protein-glutamate methylesterase activity
I5818_15755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5818_15755	COG1776	CheC inhibitor of MCP methylation
I5818_15760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5818_15765	COG1580	Controls the rotational direction of flagella during chemotaxis
I5818_15770	COG1582	Flagellar protein (FlbD)
I5818_15775	COG4786	Flagellar basal body rod
I5818_15785	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I5818_15805	COG1157	protein secretion by the type III secretion system
I5818_15810	COG1317	bacterial-type flagellum organization
I5818_15815	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I5818_15820	COG1766	The M ring may be actively involved in energy transduction
I5818_15825	COG1677	Flagellar hook-basal body complex protein FliE
I5818_15830	COG1558	bacterial-type flagellum-dependent cell motility
I5818_15835	COG1815	bacterial-type flagellum-dependent cell motility
I5818_15840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5818_15845	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I5818_15850	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I5818_15855	COG4974	Belongs to the 'phage' integrase family
I5818_15860	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I5818_15870	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I5818_15880	COG2257	FlhB HrpN YscU SpaS Family
I5818_15890	COG1657	PFAM Prenyltransferase squalene oxidase
I5818_15895	COG1979	alcohol dehydrogenase
I5818_15905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I5818_15920	COG0336	Belongs to the RNA methyltransferase TrmD family
I5818_15925	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I5818_15935	COG1837	Belongs to the UPF0109 family
I5818_15940	COG0228	four-way junction DNA binding
I5818_15945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I5818_15950	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I5818_15955	COG0552	protein localization to endoplasmic reticulum
I5818_15960	COG1196	nuclear chromosome segregation
I5818_15975	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_15980	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I5818_15985	COG0416	fatty acid biosynthetic process
I5818_15995	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I5818_16000	COG1760	l-serine dehydratase
I5818_16005	COG1760	l-serine dehydratase
I5818_16010	COG1461	Dihydroxyacetone kinase
I5818_16015	COG1302	Protein conserved in bacteria
I5818_16020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I5818_16030	COG1564	THIamine pyrophosphokinase
I5818_16035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I5818_16040	COG1162	GTPase activity
I5818_16045	COG0515	serine threonine protein kinase
I5818_16045	COG2815	serine threonine protein kinase
I5818_16050	COG0631	protein serine/threonine phosphatase activity
I5818_16055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I5818_16055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I5818_16060	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I5818_16065	COG0242	peptide deformylase activity
I5818_16070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5818_16075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5818_16085	COG0194	GDP metabolic process
I5818_16090	COG2052	Domain of unknown function (DUF370)
I5818_16095	COG1561	YicC-like family, N-terminal region
I5818_16100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I5818_16115	COG0284	orotidine-5'-phosphate decarboxylase activity
I5818_16120	COG0167	dihydroorotate dehydrogenase activity
I5818_16140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_16145	COG0540	Belongs to the ATCase OTCase family
I5818_16155	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I5818_16160	COG0564	pseudouridine synthase activity
I5818_16165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I5818_16180	COG3599	regulation of cell shape
I5818_16185	COG2302	S4 RNA-binding domain
I5818_16190	COG0762	integral membrane protein
I5818_16195	COG1799	cell septum assembly
I5818_16200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I5818_16205	COG1496	oxidoreductase activity
I5818_16210	COG1873	PFAM PRC-barrel domain
I5818_16215	COG1191	sigma factor activity
I5818_16220	COG1191	sigma factor activity
I5818_16230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I5818_16235	COG0849	cell division
I5818_16240	COG3856	small basic protein
I5818_16245	COG3879	Bacterial protein of unknown function (DUF881)
I5818_16250	COG3879	Bacterial protein of unknown function (DUF881)
I5818_16255	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I5818_16260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5818_16265	COG0772	Belongs to the SEDS family
I5818_16275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_16290	COG0768	penicillin binding
I5818_16295	COG0768	penicillin binding
I5818_16300	COG4839	cell division protein FtsL
I5818_16305	COG0275	rRNA processing
I5818_16310	COG2001	Belongs to the MraZ family
I5818_16315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
I5818_16325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I5818_16330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I5818_16340	COG0439	Biotin carboxylase
I5818_16345	COG0454	-acetyltransferase
I5818_16355	COG1024	Enoyl-CoA hydratase
I5818_16360	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I5818_16365	COG1399	metal-binding, possibly nucleic acid-binding protein
I5818_16375	COG1323	Belongs to the UPF0348 family
I5818_16380	COG3480	Lon protease (S16) C-terminal proteolytic domain
I5818_16385	COG1752	Esterase of the alpha-beta hydrolase superfamily
I5818_16390	COG3314	Sporulation integral membrane protein YlbJ
I5818_16395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I5818_16400	COG0742	ribosomal rna small subunit methyltransferase
I5818_16415	COG4471	UPF0298 protein
I5818_16420	COG3679	Belongs to the UPF0342 family
I5818_16445	COG2340	Cysteine-rich secretory protein family
I5818_16460	COG3336	cytochrome c oxidase
I5818_16480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I5818_16480	COG2010	Cytochrome c
I5818_16490	COG1612	heme a metabolic process
I5818_16495	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I5818_16500	COG0772	Belongs to the SEDS family
I5818_16515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I5818_16525	COG4896	Protein conserved in bacteria
I5818_16535	COG1217	gtp-binding protein TYPA
I5818_16545	COG0483	inositol monophosphate 1-phosphatase activity
I5818_16555	COG4493	Belongs to the UPF0637 family
I5818_16560	COG4476	Belongs to the UPF0223 family
I5818_16570	COG1982	Orn Lys Arg decarboxylase major
I5818_16590	COG0022	dehydrogenase e1 component
I5818_16605	COG0497	DNA recombination
I5818_16615	COG0561	phosphatase activity
I5818_16625	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I5818_16630	COG0569	domain protein
I5818_16635	COG2197	response regulator
I5818_16640	COG4585	Histidine kinase
I5818_16645	COG4758	membrane
I5818_16660	COG1132	(ABC) transporter
I5818_16665	COG1132	(ABC) transporter
I5818_16670	COG0668	transmembrane transport
I5818_16675	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I5818_16695	COG0714	Associated with various cellular activities
I5818_16710	COG1131	(ABC) transporter
I5818_16720	COG1119	ATPase activity
I5818_16725	COG1473	amidohydrolase
I5818_16730	COG2171	N-acyltransferase activity
I5818_16735	COG0583	DNA-binding transcription factor activity
I5818_16740	COG1595	DNA-templated transcription, initiation
I5818_16750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I5818_16750	COG2755	lipolytic protein G-D-S-L family
I5818_16755	COG0517	IMP dehydrogenase activity
I5818_16780	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5818_16785	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_16795	COG1408	metallophosphoesterase
I5818_16800	COG3300	MHYT domain
I5818_16800	COG5001	Diguanylate cyclase
I5818_16805	COG2409	Drug exporters of the RND superfamily
I5818_16805	COG1033	growth of symbiont in host cell
I5818_16810	COG1846	Transcriptional regulator
I5818_16820	COG0784	Response regulator, receiver
I5818_16820	COG0835	chemotaxis
I5818_16825	COG1714	RDD family
I5818_16830	COG0436	Aminotransferase
I5818_16840	COG2084	Dehydrogenase
I5818_16845	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_16850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5818_16870	COG0714	Associated with various cellular activities
I5818_16885	COG4873	Protein conserved in bacteria
I5818_16895	COG3949	Membrane
I5818_16900	COG0542	response to heat
I5818_16910	COG1846	Transcriptional regulator
I5818_16915	COG3852	Histidine kinase
I5818_16925	COG5002	protein histidine kinase activity
I5818_16930	COG1032	radical SAM domain protein
I5818_16945	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I5818_16960	COG1191	sigma factor activity
I5818_16965	COG0861	Integral membrane protein TerC family
I5818_16980	COG1757	Na H antiporter
I5818_16985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_16990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I5818_17015	COG1363	Peptidase, m42
I5818_17020	COG1764	response to oxidative stress
I5818_17025	COG4191	Histidine kinase
I5818_17035	COG0673	inositol 2-dehydrogenase activity
I5818_17050	COG1388	LysM domain
I5818_17050	COG4641	Protein conserved in bacteria
I5818_17055	COG1388	LysM domain
I5818_17055	COG4641	Protein conserved in bacteria
I5818_17060	COG0673	inositol 2-dehydrogenase activity
I5818_17080	COG1247	-acetyltransferase
I5818_17090	COG2382	esterase
I5818_17095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I5818_17100	COG2153	protein acetylation
I5818_17105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I5818_17130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_17200	COG0457	Tetratricopeptide repeat
I5818_17200	COG0463	Glycosyl transferase, family 2
I5818_17210	COG0673	inositol 2-dehydrogenase activity
I5818_17245	COG1388	LysM domain
I5818_17245	COG4641	Protein conserved in bacteria
I5818_17255	COG0569	domain protein
I5818_17255	COG0475	glutathione-regulated potassium exporter activity
I5818_17265	COG0564	pseudouridine synthase activity
I5818_17275	COG2357	RelA SpoT domain protein
I5818_17280	COG4116	CYTH
I5818_17285	COG0741	lytic transglycosylase activity
I5818_17290	COG2346	COG2346, Truncated hemoglobins
I5818_17295	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I5818_17300	COG1164	Oligoendopeptidase f
I5818_17305	COG4469	Competence protein
I5818_17310	COG4862	establishment of competence for transformation
I5818_17315	COG1393	Belongs to the ArsC family
I5818_17320	COG0456	acetyltransferase
I5818_17325	COG0180	Tryptophanyl-tRNA synthetase
I5818_17340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_17345	COG0601	transmembrane transport
I5818_17355	COG4608	Belongs to the ABC transporter superfamily
I5818_17360	COG0444	Belongs to the ABC transporter superfamily
I5818_17365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_17370	COG0601	transmembrane transport
I5818_17380	COG4608	Belongs to the ABC transporter superfamily
I5818_17385	COG0444	Belongs to the ABC transporter superfamily
I5818_17390	COG5504	Zn-dependent protease
I5818_17395	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I5818_17400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_17415	COG1744	ABC transporter substrate-binding protein PnrA-like
I5818_17425	COG2267	carboxylic ester hydrolase activity
I5818_17435	COG0542	response to heat
I5818_17445	COG2151	metal-sulfur cluster biosynthetic enzyme
I5818_17450	COG1073	alpha beta
I5818_17455	COG0561	phosphatase activity
I5818_17470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_17475	COG1307	EDD domain protein, DegV family
I5818_17485	COG1666	GTP binding
I5818_17495	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_17500	COG0366	Alpha amylase catalytic
I5818_17500	COG1874	Beta-galactosidase
I5818_17510	COG5001	Diguanylate cyclase
I5818_17510	COG3300	MHYT domain
I5818_17520	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5818_17525	COG2311	Membrane
I5818_17560	COG1074	ATP-dependent DNA helicase activity
I5818_17565	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I5818_17575	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_17580	COG0398	Pfam SNARE associated Golgi protein
I5818_17585	COG0823	Involved in the tonB-independent uptake of proteins
I5818_17585	COG1506	peptidase
I5818_17585	COG4946	Tricorn protease homolog
I5818_17595	COG4903	ComK protein
I5818_17605	COG0501	Belongs to the peptidase M48B family
I5818_17610	COG2755	lipolytic protein G-D-S-L family
I5818_17620	COG1024	Enoyl-CoA hydratase
I5818_17625	COG0318	PFAM AMP-dependent synthetase and ligase
I5818_17630	COG0095	Lipoate-protein ligase
I5818_17635	COG1234	tRNA 3'-trailer cleavage
I5818_17645	COG1999	signal sequence binding
I5818_17650	COG1511	domain protein
I5818_17655	COG1309	transcriptional regulator
I5818_17660	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5818_17665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I5818_17670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I5818_17680	COG2197	response regulator
I5818_17685	COG4585	Histidine kinase
I5818_17695	COG3069	C4-dicarboxylate transmembrane transporter activity
I5818_17755	COG1473	amidohydrolase
I5818_17765	COG4473	ABC transporter
I5818_17770	COG1131	(ABC) transporter
I5818_17775	COG0537	adenosine 5'-monophosphoramidase activity
I5818_17780	COG4980	gas vesicle protein
I5818_17785	COG1846	Transcriptional regulator
I5818_17810	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I5818_17820	COG3481	metal-dependent phosphohydrolase, HD sub domain
I5818_17825	COG4717	serine-type aminopeptidase activity
I5818_17830	COG0420	3'-5' exonuclease activity
I5818_17835	COG1668	transmembrane transport
I5818_17840	COG4152	abc transporter atp-binding protein
I5818_17845	COG0861	Integral membrane protein TerC family
I5818_17855	COG1024	Enoyl-CoA hydratase
I5818_17860	COG2910	NAD(P)H-binding
I5818_17865	COG1959	2 iron, 2 sulfur cluster binding
I5818_17870	COG0561	phosphatase activity
I5818_17885	COG0189	ligase activity
I5818_17890	COG0189	ligase activity
I5818_17910	COG2508	Transcriptional regulator
I5818_17915	COG3842	ATPase activity
I5818_17940	COG2814	Major facilitator Superfamily
I5818_17945	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5818_17950	COG3852	Histidine kinase
I5818_17970	COG0659	secondary active sulfate transmembrane transporter activity
I5818_17975	COG1012	belongs to the aldehyde dehydrogenase family
I5818_17985	COG4608	Belongs to the ABC transporter superfamily
I5818_17990	COG0444	Belongs to the ABC transporter superfamily
I5818_17995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_18000	COG0601	transmembrane transport
I5818_18005	COG4166	transmembrane transport
I5818_18020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I5818_18025	COG0598	Magnesium transport protein CorA
I5818_18035	COG1280	lysine exporter protein (LysE YggA)
I5818_18080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5818_18085	COG2271	Major facilitator Superfamily
I5818_18090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I5818_18095	COG2267	carboxylic ester hydrolase activity
I5818_18105	COG1253	flavin adenine dinucleotide binding
I5818_18115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I5818_18140	COG1012	belongs to the aldehyde dehydrogenase family
I5818_18180	COG4191	Histidine kinase
I5818_18190	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_18240	COG1122	ATPase activity
I5818_18245	COG1122	ATPase activity
I5818_18275	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_18280	COG0789	Transcriptional regulator
I5818_18300	COG0477	Major facilitator Superfamily
I5818_18335	COG2719	SpoVR family
I5818_18370	COG0564	pseudouridine synthase activity
I5818_18385	COG1960	acyl-CoA dehydrogenase activity
I5818_18390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I5818_18395	COG0655	NAD(P)H dehydrogenase (quinone) activity
I5818_18400	COG1392	Phosphate transport regulator
I5818_18405	COG0306	phosphate transporter
I5818_18420	COG2252	PERMEase
I5818_18430	COG2814	Major facilitator Superfamily
I5818_18440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I5818_18445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I5818_18450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I5818_18475	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_18485	COG2409	Drug exporters of the RND superfamily
I5818_18490	COG2197	response regulator
I5818_18495	COG4585	Histidine kinase
I5818_18505	COG1687	branched-chain amino acid
I5818_18510	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I5818_18515	COG1522	sequence-specific DNA binding
I5818_18525	COG2124	cytochrome p450
I5818_18575	COG0587	DNA-directed DNA polymerase activity
I5818_18600	COG1309	transcriptional regulator
I5818_18615	COG2814	Major facilitator Superfamily
I5818_18620	COG0583	DNA-binding transcription factor activity
I5818_18630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I5818_18660	COG0346	lactoylglutathione lyase activity
I5818_18665	COG1683	Conserved Protein
I5818_18680	COG1309	transcriptional regulator
I5818_18700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5818_18715	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I5818_18725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I5818_18735	COG1136	(ABC) transporter
I5818_18755	COG0022	dehydrogenase e1 component
I5818_18765	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_18775	COG1122	ATPase activity
I5818_18795	COG3327	negative regulation of DNA-templated transcription, initiation
I5818_18800	COG0183	Belongs to the thiolase family
I5818_18805	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_18810	COG1024	Enoyl-CoA hydratase
I5818_18825	COG2151	metal-sulfur cluster biosynthetic enzyme
I5818_18840	COG3396	Phenylacetate-CoA oxygenase
I5818_18845	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I5818_18850	COG3104	oligopeptide transport
I5818_18875	COG0179	Fumarylacetoacetate (FAA) hydrolase
I5818_18890	COG1012	belongs to the aldehyde dehydrogenase family
I5818_18895	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I5818_18900	COG0583	DNA-binding transcription factor activity
I5818_18905	COG2814	Major facilitator Superfamily
I5818_18910	COG0726	polysaccharide deacetylase
I5818_18915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I5818_18920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_18920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_18925	COG0307	riboflavin synthase, alpha
I5818_18930	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5818_18930	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I5818_18935	COG0753	catalase activity
I5818_18965	COG2718	Belongs to the UPF0229 family
I5818_18970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_18975	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_18985	COG2766	serine protein kinase
I5818_18990	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I5818_19005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I5818_19015	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_19015	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I5818_19025	COG1595	DNA-templated transcription, initiation
I5818_19050	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I5818_19055	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I5818_19060	COG1131	(ABC) transporter
I5818_19065	COG2755	lipolytic protein G-D-S-L family
I5818_19095	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_19105	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I5818_19110	COG2814	Major facilitator Superfamily
I5818_19120	COG1476	TRANSCRIPTIONal
I5818_19130	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_19170	COG0402	S-adenosylhomocysteine deaminase activity
I5818_19175	COG0402	S-adenosylhomocysteine deaminase activity
I5818_19180	COG0590	tRNA wobble adenosine to inosine editing
I5818_19190	COG0583	DNA-binding transcription factor activity
I5818_19200	COG0860	N-Acetylmuramoyl-L-alanine amidase
I5818_19225	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I5818_19225	COG3264	Mechanosensitive ion channel
I5818_19260	COG4187	Peptidase family M20/M25/M40
I5818_19290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I5818_19295	COG2304	oxidoreductase activity
I5818_19325	COG1309	transcriptional regulator
I5818_19330	COG2814	Major facilitator Superfamily
I5818_19335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_19350	COG0305	Participates in initiation and elongation during chromosome replication
I5818_19360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I5818_19380	COG0288	reversible hydration of carbon dioxide
I5818_19385	COG3002	Belongs to the UPF0753 family
I5818_19390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I5818_19395	COG5609	conserved protein (DUF2294)
I5818_19465	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_19470	COG2030	dehydratase
I5818_19490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I5818_19505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I5818_19695	COG0735	belongs to the Fur family
I5818_19700	COG2096	Adenosyltransferase
I5818_19710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I5818_19720	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I5818_19725	COG4129	membrane
I5818_19730	COG1132	(ABC) transporter
I5818_19735	COG3557	Belongs to the UPF0374 family
I5818_19755	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_19765	COG0583	DNA-binding transcription factor activity
I5818_19770	COG0067	glutamate synthase
I5818_19770	COG0069	glutamate synthase activity
I5818_19770	COG0070	glutamate synthase
I5818_19775	COG0493	'glutamate synthase
I5818_19780	COG1194	a g-specific adenine glycosylase
I5818_19785	COG1988	membrane-bound metal-dependent
I5818_19805	COG2137	regulation of response to DNA damage stimulus
I5818_19830	COG0159	tryptophan synthase activity
I5818_19850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I5818_19850	COG0512	Glutamine amidotransferase of anthranilate synthase
I5818_19855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I5818_19870	COG0673	inositol 2-dehydrogenase activity
I5818_19880	COG3833	ABC-type maltose transport systems, permease component
I5818_19885	COG1175	transmembrane transport
I5818_19890	COG2182	Extracellular solute-binding protein
I5818_19905	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5818_19910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I5818_19920	COG5416	Lipopolysaccharide assembly protein A domain
I5818_19935	COG0066	3-isopropylmalate dehydratase activity
I5818_19940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I5818_19950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I5818_19955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I5818_19960	COG0440	acetolactate synthase activity
I5818_19965	COG0028	Belongs to the TPP enzyme family
I5818_19970	COG0129	dihydroxy-acid dehydratase activity
I5818_19980	COG0460	homoserine dehydrogenase
I5818_19985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I5818_19990	COG0083	homoserine kinase activity
I5818_20000	COG1012	belongs to the aldehyde dehydrogenase family
I5818_20005	COG0028	Belongs to the TPP enzyme family
I5818_20010	COG0069	glutamate synthase activity
I5818_20040	COG2723	6-phospho-beta-galactosidase activity
I5818_20045	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_20045	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_20050	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_20060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_20070	COG2814	Major facilitator Superfamily
I5818_20075	COG0640	Transcriptional regulator
I5818_20080	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_20090	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_20115	COG1725	Transcriptional regulator
I5818_20125	COG1917	Cupin 2, conserved barrel domain protein
I5818_20125	COG2207	Transcriptional regulator
I5818_20130	COG0697	spore germination
I5818_20140	COG1819	glycosyl
I5818_20145	COG0124	histidyl-tRNA synthetase
I5818_20170	COG0561	phosphatase activity
I5818_20180	COG1940	carbohydrate kinase activity
I5818_20185	COG3708	Transcriptional regulator
I5818_20185	COG2207	Transcriptional regulator
I5818_20200	COG0475	glutathione-regulated potassium exporter activity
I5818_20215	COG0640	Transcriptional regulator
I5818_20225	COG2890	protein-(glutamine-N5) methyltransferase activity
I5818_20265	COG0583	DNA-binding transcription factor activity
I5818_20270	COG1942	4-Oxalocrotonate Tautomerase
I5818_20275	COG2070	2-Nitropropane dioxygenase
I5818_20280	COG1846	Transcriptional regulator
I5818_20285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_20305	COG0640	Transcriptional regulator
I5818_20325	COG1522	sequence-specific DNA binding
I5818_20360	COG2871	sodium ion transport
I5818_20365	COG5646	InterPro IPR014922
I5818_20375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_20385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_20390	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I5818_20400	COG0384	phenazine biosynthesis protein PhzF
I5818_20415	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_20425	COG0604	alcohol dehydrogenase
I5818_20430	COG0640	Transcriptional regulator
I5818_20435	COG1335	isochorismatase
I5818_20450	COG0789	Transcriptional regulator
I5818_20465	COG3963	phosphatidate phosphatase activity
I5818_20475	COG2318	DinB family
I5818_20480	COG2378	regulation of single-species biofilm formation
I5818_20500	COG1279	arginine transmembrane transporter activity
I5818_20505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I5818_20515	COG1288	antiporter activity
I5818_20520	COG3279	Response regulator of the LytR AlgR family
I5818_20525	COG3275	phosphorelay sensor kinase activity
I5818_20530	COG0662	Cupin 2, conserved barrel domain protein
I5818_20560	COG1017	nitric oxide dioxygenase activity
I5818_20560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I5818_20565	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I5818_20570	COG0583	DNA-binding transcription factor activity
I5818_20580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_20585	COG2072	flavoprotein involved in K transport
I5818_20595	COG0561	phosphatase activity
I5818_20600	COG1609	Transcriptional regulator
I5818_20610	COG0346	lactoylglutathione lyase activity
I5818_20615	COG0640	Transcriptional regulator
I5818_20630	COG0702	epimerase
I5818_20635	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I5818_20650	COG1278	Cold shock
I5818_20655	COG0456	acetyltransferase
I5818_20660	COG1846	Transcriptional regulator
I5818_20680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5818_20695	COG2318	DinB family
I5818_20700	COG1595	DNA-templated transcription, initiation
I5818_20715	COG0488	(ABC) transporter
I5818_20740	COG0667	Aldo Keto reductase
I5818_20750	COG1309	transcriptional regulator
I5818_20790	COG0574	Belongs to the PEP-utilizing enzyme family
I5818_20790	COG3848	Pyruvate phosphate dikinase
I5818_20795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I5818_20800	COG3546	catalase activity
I5818_20830	COG2378	regulation of single-species biofilm formation
I5818_20860	COG0500	methyltransferase
I5818_20875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I5818_20900	COG1051	belongs to the nudix hydrolase family
I5818_20920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I5818_20935	COG0583	DNA-binding transcription factor activity
I5818_20955	COG3739	integral membrane protein
I5818_20960	COG3655	Transcriptional regulator
I5818_20980	COG1404	Belongs to the peptidase S8 family
I5818_20995	COG2814	Major facilitator Superfamily
I5818_21000	COG0789	Transcriptional regulator
I5818_21005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I5818_21010	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I5818_21035	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I5818_21040	COG1492	cobalamin metabolic process
I5818_21050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I5818_21055	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I5818_21060	COG1120	ATPase activity
I5818_21065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_21070	COG2096	Adenosyltransferase
I5818_21075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_21080	COG0733	neurotransmitter:sodium symporter activity
I5818_21085	COG1605	Chorismate mutase
I5818_21085	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I5818_21090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I5818_21095	COG0095	Lipoate-protein ligase
I5818_21100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I5818_21105	COG1051	belongs to the nudix hydrolase family
I5818_21110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I5818_21125	COG0583	DNA-binding transcription factor activity
I5818_21130	COG1607	acyl-coa hydrolase
I5818_21165	COG4895	conserved protein (DUF2196)
I5818_21170	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_21180	COG3243	poly(R)-hydroxyalkanoic acid synthase
I5818_21185	COG0745	RESPONSE REGULATOR receiver
I5818_21210	COG0477	Major facilitator Superfamily
I5818_21225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I5818_21235	COG0686	Belongs to the AlaDH PNT family
I5818_21240	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I5818_21240	COG2508	Transcriptional regulator
I5818_21245	COG1113	amino acid transport
I5818_21250	COG0778	Nitroreductase
I5818_21255	COG1733	regulation of RNA biosynthetic process
I5818_21260	COG1115	amino acid carrier protein
I5818_21270	COG0517	IMP dehydrogenase activity
I5818_21270	COG0516	GMP reductase activity
I5818_21280	COG2346	COG2346, Truncated hemoglobins
I5818_21285	COG3706	GGDEF domain
I5818_21290	COG0840	transmembrane signaling receptor activity
I5818_21295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I5818_21315	COG0840	transmembrane signaling receptor activity
I5818_21340	COG1566	PFAM secretion protein HlyD family protein
I5818_21355	COG4608	Belongs to the ABC transporter superfamily
I5818_21360	COG0444	Belongs to the ABC transporter superfamily
I5818_21365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_21370	COG0601	transmembrane transport
I5818_21375	COG4166	transmembrane transport
I5818_21385	COG2205	protein histidine kinase activity
I5818_21395	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_21400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I5818_21430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I5818_21435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I5818_21440	COG2169	Transcriptional regulator
I5818_21460	COG0535	radical SAM domain protein
I5818_21475	COG0387	Pfam Sodium calcium exchanger
I5818_21480	COG0477	Major facilitator Superfamily
I5818_21485	COG2217	Heavy metal translocating P-type atpase
I5818_21495	COG1295	ribonuclease BN
I5818_21500	COG4840	Belongs to the UPF0435 family
I5818_21510	COG0024	Methionine aminopeptidase
I5818_21515	COG1360	Flagellar Motor Protein
I5818_21520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I5818_21540	COG1959	2 iron, 2 sulfur cluster binding
I5818_21550	COG2309	aminopeptidase activity
I5818_21555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I5818_21560	COG2986	histidine ammonia-lyase
I5818_21565	COG1607	acyl-coa hydrolase
I5818_21570	COG0701	Predicted permease
I5818_21575	COG3689	TIGRFAM TIGR03943 family protein
I5818_21580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_21585	COG1077	Cell shape determining protein MreB Mrl
I5818_21590	COG2268	Band 7 protein
I5818_21595	COG1585	Membrane protein implicated in regulation of membrane protease activity
I5818_21600	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I5818_21615	COG0626	cystathionine gamma-synthase activity
I5818_21620	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I5818_21625	COG1854	S-ribosylhomocysteine lyase activity
I5818_21635	COG0288	reversible hydration of carbon dioxide
I5818_21650	COG5002	protein histidine kinase activity
I5818_21670	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I5818_21670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_21670	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I5818_21680	COG2376	Dihydroxyacetone kinase
I5818_21685	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I5818_21690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I5818_21695	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I5818_21705	COG1252	NADH dehydrogenase
I5818_21800	COG3299	homolog of phage Mu protein gp47
I5818_21915	COG3728	DNA packaging
I5818_21915	COG5484	DNA packaging
I5818_21930	COG3677	Transposase
I5818_22085	COG1396	sequence-specific DNA binding
I5818_22090	COG2856	Zn peptidase
I5818_22120	COG0582	viral genome integration into host DNA
I5818_22135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_22145	COG0285	dihydrofolate synthase activity
I5818_22150	COG3706	GGDEF domain
I5818_22155	COG1414	Transcriptional regulator
I5818_22165	COG1012	belongs to the aldehyde dehydrogenase family
I5818_22170	COG0028	Belongs to the TPP enzyme family
I5818_22175	COG0436	Aminotransferase
I5818_22180	COG1757	Na H antiporter
I5818_22190	COG1447	Phosphotransferase system cellobiose-specific component IIA
I5818_22195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_22200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I5818_22205	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5818_22205	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5818_22210	COG2244	polysaccharide biosynthetic process
I5818_22215	COG1268	BioY protein
I5818_22220	COG0024	Methionine aminopeptidase
I5818_22240	COG0488	(ABC) transporter
I5818_22260	COG0513	Belongs to the DEAD box helicase family
I5818_22280	COG2205	protein histidine kinase activity
I5818_22285	COG3973	AAA domain
I5818_22290	COG1278	Cold shock
I5818_22295	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_22295	COG3321	synthase
I5818_22295	COG0604	alcohol dehydrogenase
I5818_22315	COG1388	LysM domain
I5818_22315	COG3584	3D domain protein
I5818_22330	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I5818_22330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5818_22345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5818_22360	COG2205	protein histidine kinase activity
I5818_22365	COG0527	aspartate kinase activity
I5818_22380	COG0166	Belongs to the GPI family
I5818_22385	COG1132	(ABC) transporter
I5818_22390	COG1132	(ABC) transporter
I5818_22395	COG0406	alpha-ribazole phosphatase activity
I5818_22400	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I5818_22405	COG3340	Belongs to the peptidase S51 family
I5818_22410	COG2309	aminopeptidase activity
I5818_22420	COG1131	(ABC) transporter
I5818_22435	COG3695	enzyme binding
I5818_22445	COG2814	Major facilitator Superfamily
I5818_22450	COG1846	Transcriptional regulator
I5818_22455	COG0534	Mate efflux family protein
I5818_22460	COG0210	DNA helicase
I5818_22470	COG0697	spore germination
I5818_22480	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_22495	COG1404	Belongs to the peptidase S8 family
I5818_22500	COG2132	Multicopper oxidase
I5818_22505	COG1966	Carbon starvation protein
I5818_22515	COG0390	transport system, permease component
I5818_22520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I5818_22530	COG2706	6-phosphogluconolactonase activity
I5818_22540	COG0589	response to stress
I5818_22560	COG2197	response regulator
I5818_22565	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I5818_22570	COG5002	protein histidine kinase activity
I5818_22570	COG3447	MASE1 domain protein
I5818_22570	COG5001	Diguanylate cyclase
I5818_22575	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I5818_22580	COG1126	abc transporter atp-binding protein
I5818_22585	COG0765	amino acid transport
I5818_22590	COG0765	amino acid transport
I5818_22595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_22600	COG3300	MHYT domain
I5818_22600	COG5001	Diguanylate cyclase
I5818_22610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I5818_22615	COG1525	nuclease
I5818_22620	COG1525	nuclease
I5818_22625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I5818_22630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I5818_22640	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I5818_22645	COG3716	PTS system mannose fructose sorbose family IID component
I5818_22650	COG3715	PTS system
I5818_22665	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I5818_22665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I5818_22670	COG0025	NhaP-type Na H and K H
I5818_22685	COG0246	Mannitol dehydrogenase
I5818_22690	COG3711	transcriptional antiterminator
I5818_22695	COG2213	PTS system mannitol-specific
I5818_22695	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_22700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I5818_22705	COG4948	Mandelate Racemase Muconate Lactonizing
I5818_22720	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
I5818_22740	COG5002	protein histidine kinase activity
I5818_22745	COG0745	RESPONSE REGULATOR receiver
I5818_22755	COG0789	Transcriptional regulator
I5818_22760	COG0494	nUDIX hydrolase
I5818_22765	COG0406	alpha-ribazole phosphatase activity
I5818_22770	COG2259	Doxx family
I5818_22775	COG1263	PTS System
I5818_22775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_22780	COG3711	transcriptional antiterminator
I5818_22785	COG2190	(PTS) system
I5818_22800	COG0300	oxidoreductase activity
I5818_22815	COG2814	Major facilitator Superfamily
I5818_22960	COG0506	proline dehydrogenase activity
I5818_22975	COG3279	Response regulator of the LytR AlgR family
I5818_22980	COG2972	Histidine kinase
I5818_22980	COG0745	RESPONSE REGULATOR receiver
I5818_22985	COG3279	Response regulator of the LytR AlgR family
I5818_23000	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I5818_23025	COG1940	carbohydrate kinase activity
I5818_23030	COG2723	6-phospho-beta-galactosidase activity
I5818_23035	COG1482	cell wall glycoprotein biosynthetic process
I5818_23060	COG1131	(ABC) transporter
I5818_23070	COG4260	virion core protein, lumpy skin disease virus
I5818_23075	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I5818_23080	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I5818_23085	COG1842	Phage shock protein A
I5818_23095	COG1595	DNA-templated transcription, initiation
I5818_23105	COG0604	alcohol dehydrogenase
I5818_23115	COG1757	Na H antiporter
I5818_23120	COG0400	carboxylic ester hydrolase activity
I5818_23125	COG0346	lactoylglutathione lyase activity
I5818_23130	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I5818_23140	COG1027	Aspartate ammonia-lyase
I5818_23150	COG2309	aminopeptidase activity
I5818_23155	COG0145	ligase activity
I5818_23165	COG1953	Uracil, thiamine, allantoin
I5818_23170	COG2508	Transcriptional regulator
I5818_23180	COG2814	Major facilitator Superfamily
I5818_23185	COG1785	Belongs to the alkaline phosphatase family
I5818_23200	COG1126	abc transporter atp-binding protein
I5818_23205	COG0765	amino acid transport
I5818_23210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_23220	COG1876	peptidase activity
I5818_23225	COG2409	Drug exporters of the RND superfamily
I5818_23225	COG1033	growth of symbiont in host cell
I5818_23230	COG1846	Transcriptional regulator
I5818_23240	COG0583	DNA-binding transcription factor activity
I5818_23260	COG4807	Protein conserved in bacteria
I5818_23270	COG4555	ABC transporter
I5818_23315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I5818_23345	COG4824	toxin secretion phage lysis holin
I5818_23415	COG0740	serine-type endopeptidase activity
I5818_23420	COG4695	Portal protein
I5818_23425	COG1802	Transcriptional regulator
I5818_23425	COG4626	Terminase
I5818_23455	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I5818_23505	COG3561	AntA/AntB antirepressor
I5818_23520	COG3226	Transcriptional regulator
I5818_23525	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_23525	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I5818_23560	COG1401	restriction endodeoxyribonuclease activity
I5818_23585	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I5818_23590	COG0789	Transcriptional regulator
I5818_23610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_23620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I5818_23635	COG1597	lipid kinase activity
I5818_23655	COG1309	transcriptional regulator
I5818_23660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_23665	COG2404	hydrolase activity, acting on ester bonds
I5818_23670	COG0400	carboxylic ester hydrolase activity
I5818_23675	COG0346	lactoylglutathione lyase activity
I5818_23680	COG0840	transmembrane signaling receptor activity
I5818_23695	COG0154	amidase activity
I5818_23700	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I5818_23705	COG2224	Isocitrate lyase
I5818_23710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I5818_23715	COG4851	CamS sex pheromone cAM373 precursor
I5818_23720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I5818_23725	COG0210	DNA helicase
I5818_23730	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
I5818_23745	COG4496	protein, YerC YecD
I5818_23750	COG1470	cell adhesion involved in biofilm formation
I5818_23765	COG0151	Belongs to the GarS family
I5818_23775	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I5818_23780	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I5818_23785	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I5818_23800	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I5818_23805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I5818_23810	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I5818_23815	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I5818_23820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I5818_23830	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I5818_23850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_23850	COG1263	PTS System
I5818_23850	COG2190	(PTS) system
I5818_23855	COG3711	transcriptional antiterminator
I5818_23860	COG2252	PERMEase
I5818_23875	COG0519	Catalyzes the synthesis of GMP from XMP
I5818_23875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I5818_23880	COG1305	Transglutaminase-like
I5818_23885	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I5818_23890	COG0714	Associated with various cellular activities
I5818_23900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I5818_23905	COG1335	isochorismatase
I5818_23910	COG0833	amino acid
I5818_23915	COG2304	oxidoreductase activity
I5818_23950	COG2304	oxidoreductase activity
I5818_23990	COG2814	Major facilitator Superfamily
I5818_24025	COG1266	CAAX protease self-immunity
I5818_24035	COG0805	protein transport
I5818_24040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I5818_24045	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I5818_24050	COG0315	cyclic pyranopterin monophosphate synthase activity
I5818_24055	COG0488	(ABC) transporter
I5818_24065	COG0456	acetyltransferase
I5818_24070	COG1214	PFAM Peptidase M22, glycoprotease
I5818_24075	COG0802	atpase or kinase
I5818_24155	COG3091	SprT-like family
I5818_24165	COG2183	response to ionizing radiation
I5818_24170	COG2208	phosphoserine phosphatase activity
I5818_24175	COG1191	sigma factor activity
I5818_24180	COG2172	sigma factor antagonist activity
I5818_24185	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_24190	COG2208	phosphoserine phosphatase activity
I5818_24195	COG2172	sigma factor antagonist activity
I5818_24200	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_24205	COG1366	Belongs to the anti-sigma-factor antagonist family
I5818_24210	COG2337	Toxic component of a toxin-antitoxin (TA) module
I5818_24215	COG0864	Transcriptional regulator
I5818_24225	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I5818_24230	COG0736	holo-[acyl-carrier-protein] synthase activity
I5818_24235	COG0705	Rhomboid family
I5818_24240	COG3428	Bacterial PH domain
I5818_24245	COG3402	PFAM membrane-flanked domain
I5818_24250	COG0513	Belongs to the DEAD box helicase family
I5818_24255	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I5818_24260	COG1181	Belongs to the D-alanine--D-alanine ligase family
I5818_24270	COG1253	flavin adenine dinucleotide binding
I5818_24275	COG0772	Belongs to the SEDS family
I5818_24280	COG0789	Transcriptional regulator
I5818_24285	COG1253	flavin adenine dinucleotide binding
I5818_24290	COG0018	arginyl-trna synthetase
I5818_24300	COG4555	ABC transporter
I5818_24310	COG2814	Major facilitator Superfamily
I5818_24315	COG1664	Polymer-forming cytoskeletal
I5818_24320	COG1664	Polymer-forming cytoskeletal
I5818_24325	COG0789	Transcriptional regulator
I5818_24330	COG2070	2-Nitropropane dioxygenase
I5818_24345	COG1785	Belongs to the alkaline phosphatase family
I5818_24350	COG4715	Zinc finger, swim domain protein
I5818_24355	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I5818_24365	COG0629	single-stranded DNA binding
I5818_24385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I5818_24395	COG4786	Flagellar basal body rod
I5818_24400	COG4786	Flagellar basal body rod
I5818_24405	COG1077	Cell shape determining protein MreB Mrl
I5818_24410	COG1609	Transcriptional regulator
I5818_24415	COG0739	heme binding
I5818_24420	COG2385	sporulation resulting in formation of a cellular spore
I5818_24425	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5818_24435	COG4836	Membrane
I5818_24440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I5818_24445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I5818_24450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I5818_24455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I5818_24460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5818_24465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I5818_24470	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I5818_24475	COG0356	it plays a direct role in the translocation of protons across the membrane
I5818_24485	COG1404	Belongs to the peptidase S8 family
I5818_24490	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I5818_24495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I5818_24510	COG0698	ribose 5-phosphate isomerase
I5818_24520	COG2814	Major facilitator Superfamily
I5818_24525	COG0840	transmembrane signaling receptor activity
I5818_24535	COG1971	Probably functions as a manganese efflux pump
I5818_24540	COG0009	L-threonylcarbamoyladenylate synthase
I5818_24565	COG0156	8-amino-7-oxononanoate synthase activity
I5818_24570	COG1435	thymidine kinase activity
I5818_24580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I5818_24585	COG1494	fructose-1,6-bisphosphatase
I5818_24590	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I5818_24595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I5818_24600	COG0191	fructose-bisphosphate aldolase activity
I5818_24605	COG2204	response regulator
I5818_24620	COG0504	CTP synthase activity
I5818_24630	COG1703	isobutyryl-CoA mutase activity
I5818_24630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_24630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I5818_24640	COG1960	acyl-CoA dehydrogenase activity
I5818_24645	COG1960	acyl-CoA dehydrogenase activity
I5818_24650	COG1250	3-hydroxyacyl-CoA dehydrogenase
I5818_24655	COG0183	Belongs to the thiolase family
I5818_24660	COG0247	lactate metabolic process
I5818_24660	COG2181	nitrate reductase activity
I5818_24665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I5818_24670	COG0018	arginyl-trna synthetase
I5818_24680	COG0730	response to heat
I5818_24685	COG0010	Belongs to the arginase family
I5818_24690	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I5818_24695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I5818_24705	COG1994	Peptidase M50
I5818_24715	COG3465	dGTPase activity
I5818_24720	COG1078	dGTPase activity
I5818_24730	COG1132	(ABC) transporter
I5818_24735	COG1132	(ABC) transporter
I5818_24745	COG0280	phosphate acetyltransferase
I5818_24750	COG3253	May function as heme-dependent peroxidase
I5818_24760	COG2363	Small membrane protein
I5818_24775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I5818_24785	COG0314	molybdopterin synthase activity
I5818_24790	COG0746	molybdenum cofactor guanylyltransferase activity
I5818_24795	COG0346	lactoylglutathione lyase activity
I5818_24815	COG0840	transmembrane signaling receptor activity
I5818_24820	COG2205	protein histidine kinase activity
I5818_24825	COG0745	RESPONSE REGULATOR receiver
I5818_24835	COG0351	phosphomethylpyrimidine kinase
I5818_24840	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I5818_24865	COG1309	transcriptional regulator
I5818_24870	COG0561	phosphatase activity
I5818_24875	COG2031	fatty acid transporter
I5818_24880	COG0514	ATP-dependent DNA helicase (RecQ)
I5818_24890	COG0156	8-amino-7-oxononanoate synthase activity
I5818_24895	COG1737	Transcriptional regulator
I5818_24900	COG0456	acetyltransferase
I5818_24900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I5818_24905	COG3876	Protein conserved in bacteria
I5818_24915	COG3842	ATPase activity
I5818_24920	COG0395	ABC-type sugar transport system, permease component
I5818_24925	COG1175	transmembrane transport
I5818_24935	COG1472	Belongs to the glycosyl hydrolase 3 family
I5818_24945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I5818_24950	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I5818_24955	COG0456	acetyltransferase
I5818_24965	COG0395	ABC-type sugar transport system, permease component
I5818_24970	COG1175	transmembrane transport
I5818_24975	COG1653	transport
I5818_24980	COG1649	PFAM Uncharacterised BCR, COG1649
I5818_24990	COG2971	BadF BadG BcrA BcrD
I5818_25000	COG1263	PTS System
I5818_25000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I5818_25010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I5818_25025	COG1247	-acetyltransferase
I5818_25030	COG3279	Response regulator of the LytR AlgR family
I5818_25035	COG0427	acetyl-CoA hydrolase
I5818_25040	COG1823	symporter activity
I5818_25050	COG0737	Belongs to the 5'-nucleotidase family
I5818_25055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I5818_25060	COG3639	organic phosphonate transmembrane transporter activity
I5818_25070	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I5818_25080	COG0367	asparagine synthase
I5818_25095	COG2966	Psort location CytoplasmicMembrane, score
I5818_25105	COG4607	ABC-type enterochelin transport system periplasmic component
I5818_25110	COG4604	ABC transporter, ATP-binding protein
I5818_25115	COG4605	iron ion homeostasis
I5818_25120	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I5818_25130	COG1126	abc transporter atp-binding protein
I5818_25135	COG0765	amino acid transport
I5818_25145	COG0488	(ABC) transporter
I5818_25150	COG0531	amino acid
I5818_25160	COG0840	transmembrane signaling receptor activity
I5818_25165	COG0492	ferredoxin-NADP+ reductase activity
I5818_25175	COG1301	dicarboxylic acid transport
I5818_25185	COG1132	(ABC) transporter
I5818_25195	COG2080	2 iron, 2 sulfur cluster binding
I5818_25210	COG2068	MobA-Related Protein
I5818_25215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I5818_25225	COG0444	Belongs to the ABC transporter superfamily
I5818_25230	COG4608	Belongs to the ABC transporter superfamily
I5818_25240	COG0601	transmembrane transport
I5818_25245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I5818_25255	COG2259	Doxx family
I5818_25270	COG5002	protein histidine kinase activity
I5818_25280	COG0667	Aldo Keto reductase
I5818_25285	COG0534	Mate efflux family protein
I5818_25290	COG2195	Cleaves the N-terminal amino acid of tripeptides
I5818_25305	COG3844	kynureninase activity
I5818_25315	COG3104	oligopeptide transport
I5818_25340	COG0805	protein transport
I5818_25355	COG1309	transcriptional regulator
I5818_25360	COG2357	RelA SpoT domain protein
I5818_25375	COG0402	S-adenosylhomocysteine deaminase activity
I5818_25380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I5818_25385	COG0583	DNA-binding transcription factor activity
I5818_25400	COG1301	dicarboxylic acid transport
I5818_25405	COG4565	transcriptional regulatory protein
I5818_25410	COG3290	protein histidine kinase activity
I5818_25415	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I5818_25420	COG1113	amino acid transport
I5818_25435	COG1725	Transcriptional regulator
I5818_25445	COG2205	protein histidine kinase activity
I5818_25450	COG0745	RESPONSE REGULATOR receiver
I5818_25460	COG0577	efflux transmembrane transporter activity
I5818_25465	COG1136	(ABC) transporter
I5818_25480	COG1028	Short-chain dehydrogenase reductase Sdr
I5818_25490	COG0450	alkyl hydroperoxide reductase
I5818_25500	COG1482	cell wall glycoprotein biosynthetic process
I5818_25505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_25505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_25505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I5818_25510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I5818_25510	COG3711	transcriptional antiterminator
I5818_25520	COG2233	PERMEase
I5818_25535	COG0765	amino acid transport
I5818_25560	COG1846	Transcriptional regulator
I5818_25570	COG0579	oxidoreductase
I5818_25575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I5818_25610	COG1349	DNA-binding transcription factor activity
I5818_25640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I5818_25680	COG0789	Transcriptional regulator
I5818_25710	COG2207	Transcriptional regulator
I5818_25720	COG2814	Major facilitator Superfamily
I5818_25725	COG4221	oxidoreductase activity
I5818_25730	COG1846	Transcriptional regulator
I5818_25735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I5818_25755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I5818_25760	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I5818_25765	COG4853	Protein conserved in bacteria
I5818_25775	COG5002	protein histidine kinase activity
I5818_25780	COG0745	RESPONSE REGULATOR receiver
I5818_25785	COG1388	LysM domain
I5818_25785	COG4942	peptidase
I5818_25805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I5818_25810	COG0305	Participates in initiation and elongation during chromosome replication
I5818_25815	COG0359	binds to the 23S rRNA
I5818_25820	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I5818_25825	COG4241	membrane
I5818_25830	COG0840	transmembrane signaling receptor activity
I5818_25835	COG1595	DNA-templated transcription, initiation
I5818_25845	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I5818_25855	COG0360	Binds together with S18 to 16S ribosomal RNA
I5818_25860	COG0012	GTP binding
I5818_25865	COG4481	Protein conserved in bacteria
I5818_25870	COG0668	transmembrane transport
I5818_25885	COG1475	DNA binding
I5818_25890	COG1192	Involved in chromosome partitioning
I5818_25895	COG1475	DNA binding
I5818_25900	COG0357	Ribosomal RNA small subunit methyltransferase G
I5818_25905	COG0445	tRNA wobble uridine modification
I5818_25910	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I5818_25915	COG1847	R3H domain protein
I5818_25920	COG0706	membrane insertase activity
I5818_25925	COG0594	ribonuclease P activity
I5818_25930	COG0230	Belongs to the bacterial ribosomal protein bL34 family