locus-tag class description FPL01_00010 ENOG4105C19 ABC transporter FPL01_00115 ENOG4108JJA ABC, transporter FPL01_00170 ENOG4107QJE Chromosome Partitioning Protein FPL01_00260 ENOG41067XF inhibitor FPL01_00320 ENOG4105EKQ RNA-directed DNA polymerase FPL01_00375 ENOG4105DHF Membrane FPL01_00420 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FPL01_00450 ENOG4105KRN Transcriptional regulator, abrb family FPL01_00460 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL01_00485 ENOG4108IBT Inherit from COG: transposase FPL01_00560 ENOG4107R0E Glycosyl transferase, family 2 FPL01_00565 ENOG4107R0E Glycosyl transferase, family 2 FPL01_00585 ENOG41086D8 Transcriptional regulator FPL01_00610 ENOG4105K59 histidine triad (HIT) protein FPL01_00660 ENOG4105VMP Transcriptional regulator FPL01_00675 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL01_00695 ENOG41090VF Stage v sporulation protein ac FPL01_00700 ENOG4105CZ3 stage V sporulation protein ad FPL01_00715 ENOG4108QY0 Membrane FPL01_00720 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FPL01_00735 ENOG4108B31 Spore germination protein FPL01_00760 ENOG4105KVH Transcriptional regulator FPL01_00770 ENOG4105C4W S-formylglutathione hydrolase FPL01_00780 ENOG4105D9M gamma-glutamylcysteine synthetase FPL01_00805 ENOG4108NHD germination protein FPL01_00820 ENOG4108W2Y isochorismatase FPL01_00835 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_00840 ENOG4105BZU Histidine kinase FPL01_00880 ENOG4105C5Y PTS System FPL01_00965 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FPL01_01095 ENOG4105EKQ RNA-directed DNA polymerase FPL01_01100 ENOG4105EKQ RNA-directed DNA polymerase FPL01_01125 ENOG4108M1A Chitin-binding protein FPL01_01140 ENOG4105EC8 Methyl-accepting chemotaxis FPL01_01145 ENOG4107SDU Methyl-accepting chemotaxis FPL01_01165 ENOG4105K4H Nlp p60 protein FPL01_01200 ENOG41080HT Transcriptional regulator, arsr family FPL01_01355 ENOG4105EKQ RNA-directed DNA polymerase FPL01_01425 ENOG4105EKQ RNA-directed DNA polymerase FPL01_01465 ENOG4105D7V transposase FPL01_01505 ENOG4105D7V transposase FPL01_01570 ENOG4105D7V transposase FPL01_01635 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FPL01_01645 ENOG4108IJ0 Aspartate ammonia-lyase FPL01_01650 ENOG4105C6K Malic enzyme FPL01_01665 ENOG4105C0D helicase FPL01_01685 ENOG41067QW Transcriptional regulator FPL01_01715 ENOG4105FVX FPL01_01765 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FPL01_01770 ENOG4105DRS transport system, permease FPL01_01780 ENOG4108X79 transcriptional regulator FPL01_01785 ENOG4105E70 isomerase FPL01_01800 ENOG4105DE4 1-phosphofructokinase FPL01_01810 ENOG4105CSR polyphosphate kinase 2 FPL01_01815 ENOG4105U3E Transcriptional regulator FPL01_01825 ENOG4105DXI Major Facilitator superfamily FPL01_01850 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FPL01_01860 ENOG4105EU0 Major facilitator Superfamily FPL01_01865 ENOG4105C6T cysteine synthase FPL01_01885 ENOG4105C8J )-transporter FPL01_01895 ENOG4105X5K response regulator receiver protein FPL01_01900 ENOG4105H67 Protein of unknown function (DUF421) FPL01_01920 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FPL01_01925 ENOG4105CHR reductase FPL01_01935 ENOG4105C7K acetolactate synthase FPL01_01955 ENOG4105C7B Threonine dehydratase FPL01_01980 ENOG4105C6X Major Facilitator FPL01_01985 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FPL01_02005 ENOG4105DY9 regulatoR FPL01_02010 ENOG4105CYC Transferase FPL01_02040 ENOG41068WN FPL01_02080 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FPL01_02085 ENOG4105C0X amino acid FPL01_02105 ENOG410829K Lysine exporter protein (Lyse ygga) FPL01_02125 ENOG4107RHR regulatoR FPL01_02135 ENOG4105D9N nucleoside FPL01_02140 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FPL01_02165 ENOG4107RAQ aminopeptidase FPL01_02220 ENOG4108T5E Copper resistance protein FPL01_02225 ENOG4105KTB nuclear export factor GLE1 FPL01_02230 ENOG4107RT3 EamA-like transporter family FPL01_02235 ENOG4105GZI Transcriptional regulator FPL01_02240 ENOG4108Z40 Transcriptional regulator FPL01_02245 ENOG4107ZXU DSBA oxidoreductase FPL01_02250 ENOG4108TVJ Nitroreductase FPL01_02260 ENOG4106F5Q Membrane FPL01_02265 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FPL01_02275 ENOG4105CKI cobalamin synthesis protein FPL01_02285 ENOG4105C0Z ABC transporter FPL01_02290 ENOG4108IV0 ABC, transporter FPL01_02295 ENOG4105C32 Amino acid ABC transporter (Permease) FPL01_02315 ENOG41090U3 tautomerase FPL01_02335 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL01_02340 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL01_02345 ENOG4108JJ9 ABC, transporter FPL01_02350 ENOG4108JJ8 (ABC) transporter FPL01_02370 ENOG4108UT6 Transferase hexapeptide repeat containing protein FPL01_02425 ENOG4105BZ1 (ABC) transporter FPL01_02435 ENOG4105BZU Histidine kinase FPL01_02445 ENOG4105D7V transposase FPL01_02460 ENOG4108VQJ O-methyltransferase FPL01_02470 ENOG4108ZJ4 polysaccharide deacetylase FPL01_02490 ENOG4105D6E homoserine dehydrogenase FPL01_02515 ENOG4108KGH TRANSCRIPTIONal FPL01_02525 ENOG4107VMI polysaccharide deacetylase FPL01_02535 ENOG4105KT7 mgtC SapB transporter FPL01_02545 ENOG4105YWU small acid-soluble spore protein FPL01_02555 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FPL01_02560 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL01_02610 ENOG4105KRN Transcriptional regulator, abrb family FPL01_02620 ENOG4105YVS arsR family transcriptional regulator FPL01_02625 ENOG4105CPC Aldo Keto reductase FPL01_02630 ENOG4107XZQ multidrug resistance protein FPL01_02635 ENOG4105KAF membrAne FPL01_02660 ENOG4105C8Q Methyl-accepting chemotaxis FPL01_02675 ENOG4108K88 Membrane FPL01_02680 ENOG4108K88 Membrane FPL01_02685 ENOG4108WPJ Ferritin-like domain FPL01_02710 ENOG4105VMI -acetyltransferase FPL01_02715 ENOG4107QM2 Aldo Keto reductase FPL01_02720 ENOG4105CKI cobalamin synthesis protein FPL01_02735 ENOG4108IBT Inherit from COG: transposase FPL01_02740 ENOG4105DSE periplasmic solute binding protein FPL01_02745 ENOG4105K4T epimerase FPL01_02755 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FPL01_02800 ENOG4107T5V SNARE associated Golgi FPL01_02825 ENOG4108S4H thioesterase Superfamily protein FPL01_02860 ENOG4105C37 (CBS) domain FPL01_02885 ENOG4108Z7R Chaperone CsaA FPL01_02905 ENOG4108ZRV stage ii sporulation protein p FPL01_02915 ENOG4108VXD carboxy-peptidase FPL01_02925 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FPL01_02945 ENOG4105EFA 4-hydroxyphenylacetate FPL01_02955 ENOG4105U1N riboflavin FPL01_02970 ENOG4105KME endoribonuclease L-psp FPL01_03000 ENOG41069HH 4-oxalocrotonate tautomerase FPL01_03010 ENOG4108X4Q Hydrolase FPL01_03020 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FPL01_03025 ENOG4107RBS Methyltransferase FPL01_03040 ENOG41087PP glycosyltransferase MGT family FPL01_03045 ENOG4108JYZ YitT family FPL01_03050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL01_03080 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FPL01_03105 ENOG4105KBJ sporulation protein ytfj FPL01_03130 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL01_03150 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FPL01_03155 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FPL01_03165 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FPL01_03170 ENOG4105EMN RNA polymerase sigma factor FPL01_03205 ENOG4108V06 Glutathione peroxidase FPL01_03220 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL01_03255 ENOG4105MCT stage V sporulation protein S FPL01_03285 ENOG4108UUM single-stranded DNA-binding protein FPL01_03315 ENOG4107YX5 Pfam:DUF548 FPL01_03320 ENOG4105C75 arginyL-tRNA synthetase FPL01_03360 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FPL01_03365 ENOG4105C5S asparaginyl-tRNA synthetase FPL01_03385 ENOG4105EC2 ftsk spoIIIe FPL01_03445 ENOG4105C8J )-transporter FPL01_03465 ENOG4107XGZ Hydrolase FPL01_03470 ENOG4105CY2 Citrate transporter FPL01_03475 ENOG4105C0A alcohol dehydrogenase FPL01_03490 ENOG4105KD7 acetyltransferase FPL01_03495 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FPL01_03520 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FPL01_03535 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FPL01_03555 ENOG4107RVG penicillin-binding protein FPL01_03565 ENOG4105E9Q Acyl-transferase FPL01_03570 ENOG4108UT2 hemolysin iii FPL01_03580 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FPL01_03590 ENOG4108RCR degv family FPL01_03595 ENOG4105E8R UPF0173 metal-dependent hydrolase FPL01_03600 ENOG4108KF3 Electron transport protein SCO1 SenC FPL01_03605 ENOG4107Y70 Heat shock protein FPL01_03610 ENOG4105CAQ asparagine synthetase FPL01_03630 ENOG4105F0I Aminotransferase FPL01_03655 ENOG4107Y70 Heat shock protein FPL01_03660 ENOG4105D8X mechanosensitive ion channel FPL01_03665 ENOG4105BZU Histidine kinase FPL01_03670 ENOG4105WH1 Two component transcriptional regulator luxr family FPL01_03715 ENOG4105CMG Carbohydrate kinase FPL01_03720 ENOG4105C6Z Gluconate FPL01_03760 ENOG4108IJ8 ABC transporter FPL01_03765 ENOG4105E90 ABC transporter FPL01_03800 ENOG4105C37 (CBS) domain FPL01_03825 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL01_03840 ENOG4107S4Y M20 DapE family protein YgeY FPL01_03845 ENOG4108TSC N-acetyltransferase FPL01_03850 ENOG4108JUB Transcriptional regulator FPL01_03860 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FPL01_03905 ENOG410841Q phosphoesterase PA-phosphatase related protein FPL01_03915 ENOG4105SZ6 Thioredoxin FPL01_03990 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL01_04045 ENOG4105DP8 Major facilitator superfamily MFS_1 FPL01_04055 ENOG4105DXD 2-methylcitrate dehydratase FPL01_04060 ENOG4105CR4 methylisocitrate lyase FPL01_04070 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL01_04080 ENOG4105N14 lysine exporter protein LysE YggA FPL01_04085 ENOG4105E39 Enoyl-CoA hydratase FPL01_04100 ENOG4107RFY SbcCD D subunit FPL01_04120 ENOG4105FCD Major Facilitator FPL01_04125 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FPL01_04130 ENOG4105E4F Isochorismate synthase FPL01_04135 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FPL01_04140 ENOG4105WQI isochorismatase FPL01_04150 ENOG4105WQT MbtH domain protein FPL01_04155 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL01_04170 ENOG4105K70 DNA-binding protein FPL01_04190 ENOG4105BZG amino acid carrier protein FPL01_04220 ENOG4105FE9 pseudouridine synthase FPL01_04225 ENOG4105C22 threonyL-tRNA synthetase FPL01_04230 ENOG4105C19 ABC transporter FPL01_04240 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FPL01_04270 ENOG4108D32 Methyltransferase FPL01_04295 ENOG41081I9 integral membrane protein FPL01_04315 ENOG4107MII Sugar-specific transcriptional regulator TrmB FPL01_04335 ENOG4105EYF MMPL domain protein FPL01_04365 ENOG4105WCN acetyltransferase FPL01_04380 ENOG4105C1Q protoporphyrinogen oxidase FPL01_04390 ENOG41068WN FPL01_04400 ENOG4105VEQ Cold shock protein FPL01_04425 ENOG4107V2S Transcriptional regulator FPL01_04430 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FPL01_04460 ENOG4105BZ1 (ABC) transporter FPL01_04490 ENOG4108JCI Transcriptional regulator FPL01_04545 ENOG4105F32 YngK protein FPL01_04570 ENOG4105RD7 BadF BadG BcrA BcrD FPL01_04590 ENOG4108INS Transcriptional regulator FPL01_04620 ENOG4105C1J atp-dependent rna helicase FPL01_04625 ENOG4108RZE Tetr family transcriptional regulator FPL01_04640 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL01_04645 ENOG41088CC tellurite resistance protein tehB FPL01_04655 ENOG4108I0C methyltransferase FPL01_04660 ENOG4107RA9 decarboxylase FPL01_04665 ENOG4105K56 Transcriptional regulator FPL01_04720 ENOG4107RVG penicillin-binding protein FPL01_04740 ENOG4107RF6 penicillin-binding protein FPL01_04750 ENOG4107RGJ metallophosphoesterase FPL01_04760 ENOG4105CJ1 ABC, transporter FPL01_04770 ENOG4107Z3H Transcriptional regulator, TetR family FPL01_04785 ENOG4105C1G acyl-Coa dehydrogenase FPL01_04790 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL01_04795 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FPL01_04805 ENOG4105E39 Enoyl-CoA hydratase FPL01_04810 ENOG4107QX3 carboxylase FPL01_04815 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FPL01_04825 ENOG4108ZHR arsR family transcriptional regulator FPL01_04835 ENOG4105WCN acetyltransferase FPL01_04865 ENOG4105T9C HD domain FPL01_04885 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FPL01_04910 ENOG41075H3 AraC family transcriptional regulator FPL01_04950 ENOG4105FQP Beta-lactamase FPL01_04960 ENOG4107Y80 Major Facilitator superfamily FPL01_04970 ENOG41089UC methyltransferase, type 11 FPL01_04985 ENOG4105CUV Homoserine Kinase FPL01_05015 ENOG4105EFA 4-hydroxyphenylacetate FPL01_05040 ENOG410900G Protein of unknown function (DUF421) FPL01_05045 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FPL01_05050 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FPL01_05060 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FPL01_05165 ENOG4105ETU transcriptional activator (TenA FPL01_05315 ENOG410667J hydrolase FPL01_05325 ENOG4105BZU Histidine kinase FPL01_05365 ENOG4108HGU Histidine kinase FPL01_05375 ENOG4105RHY Pfam:UPF0157 FPL01_05385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_05390 ENOG4105GR3 Histidine kinase FPL01_05395 ENOG4105CB2 alcohol dehydrogenase FPL01_05400 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FPL01_05405 ENOG4105CJN penicillin-binding protein FPL01_05410 ENOG4108IG5 Transcriptional regulator FPL01_05485 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FPL01_05510 ENOG4107Y80 Major Facilitator superfamily FPL01_05525 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FPL01_05580 ENOG4105FCD Major Facilitator FPL01_05585 ENOG4105E09 nadh pyrophosphatase FPL01_05590 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FPL01_05595 ENOG4108Z4K mutator MutT protein FPL01_05615 ENOG4108XI2 Domain of unknown function (DUF1963) FPL01_05635 ENOG4108NRW Phospholipase, patatin family FPL01_05640 ENOG4105KWG Pfam:DUF1696 FPL01_05650 ENOG4108YYS metal-dependent hydrolase (By similarity) FPL01_05675 ENOG4105PKS Excinuclease abc c subunit domain protein FPL01_05710 ENOG4107VFR oxidoreductase FPL01_05730 ENOG4105PAD Hydrolase FPL01_05765 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FPL01_05770 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FPL01_05785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL01_05790 ENOG4105CIS alcohol dehydrogenase FPL01_05840 ENOG4105MSI germination protein ypeb FPL01_05925 ENOG4108MK9 spermidine N(1)-acetyltransferase FPL01_05950 ENOG4107QKR Dehydrogenase FPL01_05960 ENOG4107RUY (E1 component), alpha subunit FPL01_05970 ENOG4105E1F short-chain dehydrogenase reductase FPL01_05975 ENOG4105RHY Pfam:UPF0157 FPL01_05990 ENOG4108TIT dATP pyrophosphohydrolase FPL01_06020 ENOG4107SQ8 Glycine betaine FPL01_06055 ENOG41082BV acetyltransferase FPL01_06090 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL01_06095 ENOG4105MSB protein, conserved in bacteria FPL01_06105 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FPL01_06170 ENOG4105C9U ATP-dependent DNA helicase RecQ FPL01_06230 ENOG4108M1A Chitin-binding protein FPL01_06250 ENOG4105BZG amino acid carrier protein FPL01_06255 ENOG4105C26 Dehydrogenase FPL01_06260 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL01_06265 ENOG4105CTU Proline racemase FPL01_06270 ENOG4105CTU Proline racemase FPL01_06275 ENOG41080HI glycine oxidase FPL01_06285 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FPL01_06315 ENOG4107T5V SNARE associated Golgi FPL01_06330 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FPL01_06335 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL01_06350 ENOG4105DTQ mandelate racemase muconate lactonizing FPL01_06410 ENOG4105BZU Histidine kinase FPL01_06445 ENOG4105DPN Oligoendopeptidase f FPL01_06460 ENOG4105EPR degv family FPL01_06505 ENOG4106K7D Major facilitator family transporter FPL01_06530 ENOG4107BMA Transglycosylase associated protein FPL01_06580 ENOG4105CHM Aminotransferase FPL01_06595 ENOG4108ZMI UPF0477 protein FPL01_06610 ENOG4105DVE abc transporter atp-binding protein FPL01_06660 ENOG4105C02 permease FPL01_06670 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FPL01_06675 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL01_06680 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FPL01_06725 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FPL01_06775 ENOG4107VMI polysaccharide deacetylase FPL01_06785 ENOG4108ZCF integral membrane protein FPL01_06790 ENOG4105E0M Sulfatase FPL01_06800 ENOG4105C5H ABC transporter FPL01_06810 ENOG4105EYF MMPL domain protein FPL01_06815 ENOG41082JN Transcriptional regulator FPL01_06845 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FPL01_06900 ENOG4105MKU Transcriptional regulator FPL01_06915 ENOG4105D4B ABC, transporter FPL01_06920 ENOG4105F5R ABC transporter FPL01_06925 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FPL01_06935 ENOG4105DKT Transcriptional regulator FPL01_06950 ENOG41061GT Aldolase FPL01_06975 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FPL01_07005 ENOG4105II7 pyrroline-5-carboxylate reductase FPL01_07015 ENOG4107258 Transcriptional regulator FPL01_07030 ENOG4105E0Y RtcB Protein FPL01_07035 ENOG4105ECK Fatty Acid Desaturase FPL01_07070 ENOG4105VMP Transcriptional regulator FPL01_07080 ENOG41090T1 Membrane FPL01_07090 ENOG4108WCX response regulator FPL01_07140 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL01_07205 ENOG4105C8Y Acetylornithine aminotransferase FPL01_07215 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FPL01_07235 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FPL01_07270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL01_07280 ENOG4108TVJ Nitroreductase FPL01_07285 ENOG4105FS7 Transcriptional regulator FPL01_07315 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FPL01_07325 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL01_07355 ENOG4108XET gCN5-related N-acetyltransferase FPL01_07415 ENOG410635A Membrane FPL01_07425 ENOG4108IQI permease FPL01_07445 ENOG4107ZY0 Phenazine biosynthesis-like protein FPL01_07510 ENOG4105P4J Allophanate hydrolase, subunit 1 FPL01_07525 ENOG4106N3A copper homeostasis protein cutc FPL01_07530 ENOG4108ZRV stage ii sporulation protein p FPL01_07535 ENOG4105FDT acyl-CoA dehydrogenase FPL01_07550 ENOG4105DWD nucleoside recognition domain protein FPL01_07585 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FPL01_07615 ENOG4105E2A Dehydrogenase FPL01_07625 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FPL01_07640 ENOG4105CGH 5'-nucleotidase FPL01_07705 ENOG4108606 TspO/MBR family FPL01_07710 ENOG4105CVP deoxyribo-dipyrimidine photolyase FPL01_07735 ENOG4105F2M alpha beta hydrolase fold-3 domain protein FPL01_07750 ENOG4108TWJ NADH dehydrogenase subunit 5 FPL01_07755 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FPL01_07770 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FPL01_07775 ENOG4105D7V transposase FPL01_07800 ENOG4105Z7P Acetyltransferase (GNAT) family FPL01_07815 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL01_07870 ENOG4108IG5 Transcriptional regulator FPL01_07885 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) FPL01_07910 ENOG4105E1K spore germination protein FPL01_07915 ENOG4105F27 Major Facilitator FPL01_07920 ENOG4105M4P Tetr family transcriptional regulator FPL01_07925 ENOG4105CHR reductase FPL01_07930 ENOG4108YXU transcriptional regulator AsnC family FPL01_08000 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FPL01_08005 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL01_08080 ENOG4105K6H D-cysteine desulfhydrase FPL01_08095 ENOG4105C88 aminopeptidase FPL01_08100 ENOG4105JQZ Methyltransferase FPL01_08120 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FPL01_08135 ENOG4105BZU Histidine kinase FPL01_08150 ENOG4108U05 Transcriptional regulator FPL01_08155 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FPL01_08165 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FPL01_08170 ENOG4105DJB Major Facilitator Superfamily FPL01_08175 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FPL01_08180 ENOG4107QR9 Iron-sulfur cluster binding protein FPL01_08190 ENOG4106P55 Transcriptional regulator FPL01_08205 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FPL01_08220 ENOG4108JQ1 Dehydrogenase FPL01_08315 ENOG4108ISG Major Facilitator FPL01_08330 ENOG4107MII Sugar-specific transcriptional regulator TrmB FPL01_08345 ENOG4105RXJ FPL01_08350 ENOG4105KPY Small multidrug resistance protein FPL01_08365 ENOG4105CRW Short chain fatty acid transporter FPL01_08375 ENOG4105DYS nad(p)h dehydrogenase (quinone) FPL01_08405 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FPL01_08440 ENOG4107SWG transcriptional regulator MERR family FPL01_08455 ENOG41067QW Transcriptional regulator FPL01_08470 ENOG4108Z66 YbaK ebsC protein FPL01_08495 ENOG4105CA9 Pyruvate kinase FPL01_08505 ENOG4108PSK reductase FPL01_08515 ENOG4105CJ1 ABC, transporter FPL01_08575 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FPL01_08580 ENOG4105DKQ ROK family FPL01_08590 ENOG4108UW5 maltose o-acetyltransferase FPL01_08595 ENOG4105C31 Tryptophanyl-tRNA synthetase FPL01_08630 ENOG4105DMQ Methyltransferase FPL01_08640 ENOG4105EV4 Multidrug resistance protein mdtH FPL01_08665 ENOG4105C37 (CBS) domain FPL01_08680 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FPL01_08685 ENOG4105FAW cDP-glucose 4,6-dehydratase FPL01_08725 ENOG4105DDN Pentapeptide repeat-containing protein FPL01_08730 ENOG4105C5Q Transcriptional regulator FPL01_08740 ENOG4105XDF Protein of unknown function (DUF1272) FPL01_08745 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FPL01_08750 ENOG4105CMG Carbohydrate kinase FPL01_08755 ENOG4105C6Z Gluconate FPL01_08760 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FPL01_08775 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FPL01_08790 ENOG4105C44 Serine transporter FPL01_08820 ENOG4108TZY GntR Family Transcriptional Regulator FPL01_08825 ENOG4105D9R oxidoreductase FPL01_08855 ENOG4105JAB phenazine biosynthesis protein, phzf family FPL01_08860 ENOG4108RU0 short-chain dehydrogenase reductase FPL01_08940 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FPL01_08980 ENOG4105VUF Transcriptional regulator FPL01_08995 ENOG4105H3G oxidoreductase FPL01_09045 ENOG4105K7K Transcriptional regulator FPL01_09050 ENOG4105CIS alcohol dehydrogenase FPL01_09075 ENOG4105D7V transposase FPL01_09095 ENOG4108TN2 lmbE family FPL01_09115 ENOG4105WCN acetyltransferase FPL01_09120 ENOG4108MES Periplasmic binding protein FPL01_09125 ENOG4105EHG Permease protein FPL01_09130 ENOG4105DQ5 transport system permease protein FPL01_09135 ENOG4105NX3 Membrane FPL01_09190 ENOG4105VZ8 Transcriptional regulator FPL01_09195 ENOG4105VZ8 Transcriptional regulator FPL01_09215 ENOG4107CUJ Protein of unknown function (DUF2690) FPL01_09225 ENOG4107V2S Transcriptional regulator FPL01_09235 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FPL01_09250 ENOG4105C98 muts2 protein FPL01_09255 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FPL01_09260 ENOG4105DPN Oligoendopeptidase f FPL01_09280 ENOG4108A04 Beta-lactamase FPL01_09320 ENOG41082BM Transcriptional regulator, arsr family FPL01_09325 ENOG4105CIS alcohol dehydrogenase FPL01_09350 ENOG4105RHY Pfam:UPF0157 FPL01_09360 ENOG4105C09 Bile acid FPL01_09365 ENOG4105CQB FAD linked oxidase domain protein FPL01_09415 ENOG4105KT7 mgtC SapB transporter FPL01_09445 ENOG4108HW4 amino acid AbC transporter FPL01_09450 ENOG41073R8 VanW family FPL01_09460 ENOG4108R1P FPL01_09475 ENOG4105VEQ Cold shock protein FPL01_09495 ENOG4105M6F mutator MutT protein FPL01_09515 ENOG410904N short-chain dehydrogenase reductase FPL01_09525 ENOG4106IQC argininosuccinate lyase FPL01_09540 ENOG4108IA2 Sodium pantothenate symporter FPL01_09550 ENOG4105C26 Dehydrogenase FPL01_09555 ENOG4105CHR reductase FPL01_09565 ENOG4105EWU Squalene--hopene cyclase FPL01_09580 ENOG410696E Membrane FPL01_09595 ENOG4105D1F ATP-binding protein FPL01_09610 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL01_09615 ENOG4105D06 uba thif-type nad fad binding protein FPL01_09620 ENOG4105TMB Formate nitrite transporter FPL01_09630 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FPL01_09635 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FPL01_09645 ENOG4108JB9 formate dehydrogenase FPL01_09735 ENOG4107QJT sodium dicarboxylate symporter FPL01_09740 ENOG4108KGH TRANSCRIPTIONal FPL01_09750 ENOG4105EMN RNA polymerase sigma factor FPL01_09765 ENOG4105CIG ABC transporter FPL01_09785 ENOG4105D9R oxidoreductase FPL01_09800 ENOG4105K4P CoA-binding domain protein FPL01_09805 ENOG4105C0H protease FPL01_09810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_09820 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FPL01_09830 ENOG4105W8X HesB YadR YfhF-family protein FPL01_09860 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FPL01_09870 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL01_09885 ENOG4108I0Z Aconitate hydratase FPL01_09915 ENOG4105E5W Transporter FPL01_09945 ENOG4107F3J Amp-dependent synthetase and ligase FPL01_09950 ENOG4107ZYJ bioY protein FPL01_09955 ENOG4105CEY Amp-dependent synthetase and ligase FPL01_09970 ENOG4108IMY Transcriptional regulator FPL01_09990 ENOG4105D9G High-affinity FPL01_09995 ENOG4105IW1 AmiS UreI transporter FPL01_10010 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FPL01_10050 ENOG4107AYK membrAne FPL01_10065 ENOG4105BZU Histidine kinase FPL01_10070 ENOG4105FBA Phospholipase Carboxylesterase FPL01_10075 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FPL01_10080 ENOG4105CK7 Sodium proline symporter FPL01_10095 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL01_10100 ENOG4108903 Formimidoylglutamase FPL01_10125 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FPL01_10175 ENOG4107QIV Cytochrome c biogenesis protein FPL01_10190 ENOG4105D7V transposase FPL01_10195 ENOG4105CH2 amidohydrolase FPL01_10205 ENOG4105CJ1 ABC, transporter FPL01_10215 ENOG4107RSM transcriptional regulator FPL01_10225 ENOG41067MG lrgb family FPL01_10250 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FPL01_10270 ENOG4105BZ1 (ABC) transporter FPL01_10275 ENOG4105BZ1 (ABC) transporter FPL01_10310 ENOG4105D5T phosphonate abc transporter FPL01_10315 ENOG4108HW3 (ABC) transporter FPL01_10320 ENOG4105CGH 5'-nucleotidase FPL01_10330 ENOG4108SVB resolvase FPL01_10350 ENOG4105K7K Transcriptional regulator FPL01_10355 ENOG4105C5F glutamine synthetase FPL01_10360 ENOG4105KV4 Transcriptional regulator FPL01_10365 ENOG4105CXI aluminum resistance protein FPL01_10370 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FPL01_10375 ENOG4105EN6 Membrane FPL01_10425 ENOG41069ER domain protein FPL01_10430 ENOG4105DM4 PTS System FPL01_10435 ENOG4105DE4 1-phosphofructokinase FPL01_10440 ENOG4105E98 transcriptional regulator DeoR family FPL01_10445 ENOG4107QW4 alcohol dehydrogenase FPL01_10450 ENOG4108SJC Membrane FPL01_10460 ENOG4105C85 amino acid FPL01_10485 ENOG4105K70 DNA-binding protein FPL01_10495 ENOG4105C59 p-type ATPase FPL01_10500 ENOG410681U heavy metal transport detoxification protein FPL01_10505 ENOG4105VPX protein, conserved in bacteria FPL01_10515 ENOG4105PGM cation diffusion facilitator family transporter FPL01_10535 ENOG4105NIV Esterase FPL01_10540 ENOG4105E0A ABC, transporter FPL01_10570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FPL01_10575 ENOG4105D03 DNA-3-methyladenine glycosylase II FPL01_10605 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FPL01_10610 ENOG4105BZU Histidine kinase FPL01_10680 ENOG4105F0V Cell wall hydrolase FPL01_10695 ENOG4105E0M Sulfatase FPL01_10700 ENOG410890F Dynamin family FPL01_10710 ENOG4107QHE Choloylglycine hydrolase FPL01_10740 ENOG4105DQU oxidoreductase, subunit beta FPL01_10745 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FPL01_10750 ENOG4108IGT Dipeptidase FPL01_10755 ENOG4105MCT stage V sporulation protein S FPL01_10760 ENOG4105D48 metallophosphoesterase FPL01_10780 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FPL01_10795 ENOG4105XZV Protein of unknown function (DUF3243) FPL01_10800 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FPL01_10820 ENOG4105UIB (ABC) transporter FPL01_10825 ENOG4108JQ9 ABC transporter FPL01_10830 ENOG4105DIH basic membrane FPL01_10835 ENOG4105FDP GntR family transcriptional regulator FPL01_10845 ENOG4107QZI cell division protein FtsK FPL01_10855 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FPL01_10870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL01_10880 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FPL01_10885 ENOG4108S0H Dipicolinic acid synthetase, b subunit FPL01_10890 ENOG4105E35 Dipicolinate synthase subunit A FPL01_10900 ENOG4105C1V Peptidase, M16 FPL01_10920 ENOG4105DTN riboflavin biosynthesis protein ribF FPL01_10935 ENOG4105W7A Protein of unknown function (DUF503) FPL01_10945 ENOG4105VHM ribosomal protein FPL01_10950 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FPL01_10955 ENOG4105CHV Transcription elongation factor NusA FPL01_10965 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FPL01_10975 ENOG4105DZP Membrane-associated zinc metalloprotease FPL01_10985 ENOG4105KNE Phosphatidate cytidylyltransferase FPL01_11030 ENOG4108HE4 integrase family FPL01_11040 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FPL01_11050 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FPL01_11065 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FPL01_11090 ENOG4105VB6 UPF0109 protein FPL01_11110 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FPL01_11115 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FPL01_11130 ENOG4105CHR reductase FPL01_11135 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FPL01_11150 ENOG4105CB5 ATP-dependent DNA helicase recG FPL01_11155 ENOG4105DP4 dak2 domain fusion protein ylov FPL01_11160 ENOG4108ZAA Alkaline-shock protein FPL01_11180 ENOG4105DJV ribulose-phosphate 3-epimerase FPL01_11190 ENOG4105D9P serine threonine protein kinase FPL01_11195 ENOG4108ZF3 Phosphatase FPL01_11205 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FPL01_11215 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL01_11220 ENOG4105C25 Primosomal protein n' FPL01_11225 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FPL01_11245 ENOG4105DSJ YicC domain protein FPL01_11260 ENOG4105D7V transposase FPL01_11270 ENOG4105F23 Fibronectin-binding protein FPL01_11280 ENOG4105DC7 peptidase M24 FPL01_11360 ENOG4105C34 Pseudouridine synthase FPL01_11385 ENOG4105DBK s4 domain protein FPL01_11400 ENOG4105DFA alanine racemase domain protein FPL01_11405 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FPL01_11410 ENOG4105WR5 sporulation protein, YlmC YmxH family FPL01_11420 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_11430 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FPL01_11435 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FPL01_11440 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FPL01_11455 ENOG4105CNI cell division protein FtsW FPL01_11470 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FPL01_11475 ENOG4105CJN penicillin-binding protein FPL01_11480 ENOG4105CJN penicillin-binding protein FPL01_11520 ENOG4105KNH Nucleic acid-binding protein FPL01_11530 ENOG41063PX domain protein FPL01_11535 ENOG4105D78 K07001 NTE family protein FPL01_11540 ENOG4105H20 Sporulation integral membrane protein YlbJ FPL01_11550 ENOG4106H78 methyltransferase FPL01_11570 ENOG4107TB6 phosphoglycerate mutase FPL01_11585 ENOG4106UY4 Inherit from COG: Scp-like extracellular FPL01_11610 ENOG4105BZ9 Cytochrome C oxidase, subunit I FPL01_11630 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FPL01_11655 ENOG4108IAB Phoh family FPL01_11675 ENOG4105QA2 FPL01_11680 ENOG4105CI3 gtp-binding protein typa FPL01_11690 ENOG4105ECY inositol monophosphatase FPL01_11710 ENOG4105CXN decarboxylase FPL01_11760 ENOG4105CPP Dehydrogenase, E1 component FPL01_11775 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL01_11780 ENOG4108X4Q Hydrolase FPL01_11795 ENOG4105CN5 Metallo-Beta-Lactamase FPL01_11800 ENOG4107ZYR domain protein FPL01_11840 ENOG4107IN1 Protein of unknown function (DUF1797) FPL01_11855 ENOG4105EPM Diguanylate phosphodiesterase FPL01_11860 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FPL01_11875 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FPL01_11940 ENOG4108HGU Histidine kinase FPL01_11950 ENOG4105CHM Aminotransferase FPL01_11955 ENOG4105FKQ transcriptional regulator FPL01_11960 ENOG4105EG2 ABC transporter, permease FPL01_11970 ENOG4107FKK extracellular solute-binding protein family 1 FPL01_11980 ENOG4105CG3 alpha amylase, catalytic region FPL01_12025 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FPL01_12030 ENOG4105CHU acetyl-coa acetyltransferase FPL01_12065 ENOG4105K7K Transcriptional regulator FPL01_12070 ENOG4105DTD Dehydrogenase FPL01_12090 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FPL01_12130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL01_12140 ENOG4106TD9 Diguanylate cyclase FPL01_12160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FPL01_12175 ENOG4105CID antiterminator FPL01_12185 ENOG4105FDP GntR family transcriptional regulator FPL01_12195 ENOG4105CE4 GlcNAc 6-P deacetylase FPL01_12240 ENOG4107ZE5 PPIases accelerate the folding of proteins FPL01_12245 ENOG4105PTM secreted protein FPL01_12250 ENOG4105J7I hydrolase FPL01_12260 ENOG4105G6R Stage v sporulation protein ae FPL01_12270 ENOG4105CZ3 stage V sporulation protein ad FPL01_12275 ENOG41090VF Stage v sporulation protein ac FPL01_12295 ENOG4105C8J )-transporter FPL01_12300 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_12310 ENOG41082AN stage II sporulation protein FPL01_12315 ENOG4105DZ1 carboxypeptidase FPL01_12325 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FPL01_12330 ENOG4105DVE abc transporter atp-binding protein FPL01_12365 ENOG4105D7N magnesium and cobalt transport protein CorA FPL01_12400 ENOG4105I3K Ferric uptake regulator, Fur family FPL01_12405 ENOG4105MZ9 stage II sporulation protein m FPL01_12425 ENOG4105CPC Aldo Keto reductase FPL01_12435 ENOG4105RHY Pfam:UPF0157 FPL01_12470 ENOG4108YM7 Gcn5-related n-acetyltransferase FPL01_12495 ENOG4108R6K riboflavin synthase, subunit alpha FPL01_12520 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL01_12525 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL01_12540 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL01_12550 ENOG4105DFD Na H antiporter FPL01_12555 ENOG4105CGH 5'-nucleotidase FPL01_12610 ENOG4108IXY short-chain dehydrogenase reductase FPL01_12615 ENOG41069FQ Metallo-beta-lactamase superfamily FPL01_12625 ENOG4105EJQ L-serine dehydratase FPL01_12660 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FPL01_12670 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FPL01_12685 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FPL01_12690 ENOG4108QEG Membrane FPL01_12695 ENOG4105CDA abc transporter atp-binding protein FPL01_12700 ENOG4105E5Q amino acid AbC transporter FPL01_12705 ENOG4108HW3 (ABC) transporter FPL01_12720 ENOG4105G7B Protein of unknown function (DUF2992) FPL01_12730 ENOG4108QY0 Membrane FPL01_12745 ENOG4105C7S Dehydrogenase FPL01_12750 ENOG4105CPP Dehydrogenase, E1 component FPL01_12770 ENOG4107RDP Dehydrogenase FPL01_12785 ENOG4108JUB Transcriptional regulator FPL01_12790 ENOG4106CCJ Protein of unknown function (DUF2627) FPL01_12795 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FPL01_12805 ENOG4107QQR Sporulation FPL01_12815 ENOG4105S1Z Stage IV sporulation protein B FPL01_12820 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FPL01_12830 ENOG4105DX0 Hemolysin A FPL01_12840 ENOG4105CTB Polyprenyl synthetase FPL01_12865 ENOG4108ZSR alkaline shock protein FPL01_12870 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL01_12895 ENOG410644B Stage III sporulation protein af FPL01_12905 ENOG4105KQ4 Stage iii sporulation protein ad FPL01_12910 ENOG4108CQH stage III sporulation protein AC FPL01_12915 ENOG4105KR5 Stage iii sporulation protein FPL01_12920 ENOG4105CD2 stage iii sporulation protein aa FPL01_12945 ENOG4105DC7 peptidase M24 FPL01_12970 ENOG4107YBY Hydrolase FPL01_13000 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FPL01_13005 ENOG4105WZW rhodanese family FPL01_13030 ENOG41080TC multidrug resistance protein FPL01_13070 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FPL01_13105 ENOG4105C0D helicase FPL01_13130 ENOG4105D7V transposase FPL01_13240 ENOG4105C3R Methionine synthase FPL01_13250 ENOG4105C28 cystathionine FPL01_13255 ENOG4105C28 cystathionine FPL01_13275 ENOG4105C5X domain protein FPL01_13285 ENOG4105DKQ ROK family FPL01_13295 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FPL01_13310 ENOG4108UTW Plays a role in the regulation of phosphate uptake FPL01_13315 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FPL01_13320 ENOG4105E2Z phosphate ABC transporter (Permease FPL01_13325 ENOG4105C8U phosphate abc transporter FPL01_13330 ENOG4105PWN phosphate abc transporter FPL01_13335 ENOG4107RF6 penicillin-binding protein FPL01_13345 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL01_13370 ENOG4105N80 Ferric uptake regulator, Fur family FPL01_13380 ENOG4105FDK ABC transporter FPL01_13385 ENOG4108JYZ YitT family FPL01_13390 ENOG41069ZM Protein of unknown function (DUF2624) FPL01_13415 ENOG4105EGD dinuclear metal center protein, YbgI family FPL01_13430 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_13435 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FPL01_13460 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FPL01_13465 ENOG4105KG3 cytidine deaminase FPL01_13470 ENOG4107YR5 Diacylglycerol kinase FPL01_13485 ENOG4105C9A Phoh family FPL01_13495 ENOG41068P3 sporulation protein YqfC FPL01_13500 ENOG4105KTH gatB Yqey FPL01_13515 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FPL01_13520 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FPL01_13550 ENOG4105CSA Coproporphyrinogen iii oxidase FPL01_13555 ENOG4105KVH Transcriptional regulator FPL01_13580 ENOG4105TQK DNA polymerase iii, delta' subunit FPL01_13590 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FPL01_13595 ENOG4108UK2 deaminase FPL01_13600 ENOG4105KQC Competence protein FPL01_13610 ENOG4105DXX methyltransferase FPL01_13620 ENOG4108WF2 Metal Dependent Phosphohydrolase FPL01_13630 ENOG410812S Rna-binding protein FPL01_13640 ENOG4105CQW ribosome biogenesis GTPase YqeH FPL01_13645 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FPL01_13660 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_13690 ENOG4105G6Z alkaline phosphatase FPL01_13700 ENOG4108MUZ hydrolase FPL01_13735 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL01_13740 ENOG4105MIR Phenylalanine 4-monooxygenase FPL01_13750 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FPL01_13790 ENOG4105S6R Iron-hydroxamate transporter permease subunit FPL01_13795 ENOG4108HUF Transporter FPL01_13805 ENOG4108EKI Dehydrogenase FPL01_13810 ENOG4105C28 cystathionine FPL01_13840 ENOG4107XRG penicillin-binding protein FPL01_13855 ENOG4105CFP Peptidase U32 FPL01_13860 ENOG4105XYU peptidase (U32 family) FPL01_13865 ENOG4108VQJ O-methyltransferase FPL01_13870 ENOG4105HHA aminodeoxychorismate lyase FPL01_13900 ENOG4105C02 permease FPL01_13915 ENOG41060CR FPL01_13920 ENOG4105C7H Helicase, RecD TraA family FPL01_13935 ENOG4105C3J Cysteine desulfurase FPL01_13945 ENOG4105D1H recombination factor protein RarA FPL01_13950 ENOG4108VCI transcription factor, rsfa family FPL01_13960 ENOG4105CUZ uba thif-type nad fad binding protein FPL01_13985 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FPL01_13995 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FPL01_14000 ENOG41076HS cation diffusion facilitator family transporter FPL01_14010 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FPL01_14020 ENOG4105CKP Polysaccharide Biosynthesis Protein FPL01_14025 ENOG4108QG2 Membrane FPL01_14035 ENOG4105VIE preprotein translocase, subunit YajC FPL01_14050 ENOG41061AI Protein of unknown function (DUF2905) FPL01_14075 ENOG41082BM Transcriptional regulator, arsr family FPL01_14105 ENOG4108IYU L-aspartate oxidase FPL01_14120 ENOG4108RPX mosc domain containing protein FPL01_14125 ENOG4105CQC Prephenate dehydratase FPL01_14145 ENOG4105EWM Histidine kinase FPL01_14175 ENOG4105C03 ribonuclease FPL01_14190 ENOG4107QMS site-determining protein FPL01_14205 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FPL01_14210 ENOG4105DFF Rod shape-determining protein mreb FPL01_14235 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FPL01_14250 ENOG41068KH stage VI sporulation protein D FPL01_14260 ENOG4105D52 delta-aminolevulinic acid dehydratase FPL01_14285 ENOG4105K56 Transcriptional regulator FPL01_14305 ENOG4108IUQ atp-dependent protease FPL01_14330 ENOG4108QCI YvbH-like oligomerisation region FPL01_14370 ENOG4105M59 Phosphodiesterase, mj0936 family FPL01_14385 ENOG4108XJQ germination protein FPL01_14405 ENOG4105KBX Transcriptional regulator, TetR family FPL01_14420 ENOG4105PFC Transcriptional regulator FPL01_14430 ENOG4105DZC cytosine deaminase FPL01_14440 ENOG4108JCI Transcriptional regulator FPL01_14450 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FPL01_14455 ENOG4108Z40 Transcriptional regulator FPL01_14460 ENOG4105RHA ABC transporter, permease FPL01_14465 ENOG4108IUX (ABC) transporter FPL01_14470 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FPL01_14475 ENOG4105ER2 Ompa motb domain protein FPL01_14480 ENOG4105E14 MotA TolQ exbB proton channel FPL01_14490 ENOG4108VXD carboxy-peptidase FPL01_14500 ENOG4105E33 succinate dehydrogenase FPL01_14510 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FPL01_14525 ENOG4105K63 Thioredoxin FPL01_14535 ENOG4105BZJ Electron transfer flavoprotein FPL01_14540 ENOG41060WC Enoyl-CoA hydratase FPL01_14545 ENOG4107Z3H Transcriptional regulator, TetR family FPL01_14550 ENOG4105CEY Amp-dependent synthetase and ligase FPL01_14590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL01_14610 ENOG4105KFN sortase, SrtB family FPL01_14630 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FPL01_14635 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FPL01_14645 ENOG4105FE9 pseudouridine synthase FPL01_14655 ENOG4105DCG PHP domain protein FPL01_14705 ENOG4108RWN rrna methyltransferase FPL01_14755 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL01_14760 ENOG4105CW7 secretion protein, HlyD family FPL01_14765 ENOG4108JGH Tetr family transcriptional regulator FPL01_14770 ENOG4105CN9 Peptidase m42 family protein FPL01_14790 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FPL01_14795 ENOG4105C22 threonyL-tRNA synthetase FPL01_14800 ENOG4108TDW sporulation protein YtxC FPL01_14820 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FPL01_14825 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FPL01_14845 ENOG4105C2M dna polymerase I FPL01_14850 ENOG4105BZU Histidine kinase FPL01_14875 ENOG4108HMX isocitrate dehydrogenase (NADP) FPL01_14880 ENOG4105BZN citrate synthase FPL01_14895 ENOG4108REF Sporulation integral membrane protein ytvi FPL01_14900 ENOG4105FS0 cytoplasmic membrane protein FPL01_14925 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FPL01_14930 ENOG4105C6K Malic enzyme FPL01_14940 ENOG4105VV2 FPL01_14950 ENOG4105SFS phosphoesterase RecJ domain protein FPL01_14990 ENOG4105DC7 peptidase M24 FPL01_15025 ENOG41082W1 Cupin 2, conserved barrel domain protein FPL01_15035 ENOG4105VZ8 Transcriptional regulator FPL01_15055 ENOG4107YZX Universal stress protein FPL01_15105 ENOG4108JYZ YitT family FPL01_15135 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FPL01_15140 ENOG4105KBJ sporulation protein ytfj FPL01_15155 ENOG4105EFZ amidohydrolase FPL01_15165 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FPL01_15190 ENOG4105C5Q Transcriptional regulator FPL01_15200 ENOG4105U5Y Transcriptional regulator FPL01_15210 ENOG4105C28 cystathionine FPL01_15315 ENOG4107R08 Integrase FPL01_15345 ENOG4105F1V Acetoin utilization protein FPL01_15350 ENOG4105W87 Cbs domain FPL01_15355 ENOG4105DGU Histone deacetylase FPL01_15370 ENOG4105EP9 oxidoreductase FPL01_15400 ENOG4105ETE Transcriptional regulator (LacI family FPL01_15425 ENOG4105C88 aminopeptidase FPL01_15455 ENOG4108IPJ Membrane FPL01_15465 ENOG4105K7K Transcriptional regulator FPL01_15495 ENOG4108VDD TRNA binding domain protein FPL01_15525 ENOG4105C8F Beta-lactamase domain protein FPL01_15545 ENOG4108IUM Glycogen debranching enzyme FPL01_15555 ENOG4107QSE Dipeptidase FPL01_15560 ENOG4105YW5 deoR family transcriptional regulator FPL01_15615 ENOG4108VJ1 Transcriptional regulator (CarD family FPL01_15620 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FPL01_15640 ENOG4108ZAF Molybdopterin FPL01_15645 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FPL01_15650 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL01_15660 ENOG4105D06 uba thif-type nad fad binding protein FPL01_15665 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FPL01_15685 ENOG41085GJ domain protein FPL01_15695 ENOG4105DWV Homoserine O-trans-acetylase FPL01_15705 ENOG4108B31 Spore germination protein FPL01_15745 ENOG410605W Major Facilitator FPL01_15750 ENOG4107S91 Sodium hydrogen exchanger FPL01_15755 ENOG4105NCW Trka-c domain protein FPL01_15775 ENOG4105C19 ABC transporter FPL01_15795 ENOG4105N5T Radical SAM Protein FPL01_15810 ENOG4105CIG ABC transporter FPL01_15835 ENOG4105D78 K07001 NTE family protein FPL01_15860 ENOG4105E8V Alpha Beta Hydrolase Fold protein FPL01_15865 ENOG4108Z0R Transferase FPL01_15870 ENOG4105YVM Phosphoesterase, PA-phosphatase related FPL01_15885 ENOG4108RIR Molybdenum cofactor biosynthesis protein FPL01_15895 ENOG4108MK9 spermidine N(1)-acetyltransferase FPL01_15935 ENOG4105EGD dinuclear metal center protein, YbgI family FPL01_15950 ENOG4105BZU Histidine kinase FPL01_15955 ENOG4105BZU Histidine kinase FPL01_15960 ENOG4107S9D Alpha beta hydrolase FPL01_15995 ENOG4105D2X ABC transporter substrate-binding protein FPL01_16005 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FPL01_16065 ENOG4108V2W Carbonate dehydratase FPL01_16070 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL01_16075 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL01_16120 ENOG41087YS Phage shock protein A FPL01_16175 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_16200 ENOG4108UGV hypoxanthine phosphoribosyltransferase FPL01_16205 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FPL01_16230 ENOG4107ZTW SNARE associated Golgi FPL01_16245 ENOG4105C19 ABC transporter FPL01_16250 ENOG41086D8 Transcriptional regulator FPL01_16260 ENOG41082BM Transcriptional regulator, arsr family FPL01_16310 ENOG4105C6Z Gluconate FPL01_16315 ENOG4105FDP GntR family transcriptional regulator FPL01_16365 ENOG4105DTQ mandelate racemase muconate lactonizing FPL01_16375 ENOG4108IPT Naphthoate synthase FPL01_16380 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FPL01_16390 ENOG4105E4F Isochorismate synthase FPL01_16395 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FPL01_16405 ENOG4105VEQ Cold shock protein FPL01_16415 ENOG4107SWG transcriptional regulator MERR family FPL01_16455 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL01_16560 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FPL01_16595 ENOG4105KT7 mgtC SapB transporter FPL01_16600 ENOG4107PBV potassium channel FPL01_16620 ENOG4105WG9 Conserved Protein FPL01_16630 ENOG4105CHM Aminotransferase FPL01_16635 ENOG4108ZB6 transcriptional regulator AsnC family FPL01_16640 ENOG4105C5I Dehydrogenase FPL01_16645 ENOG4108MUZ hydrolase FPL01_16655 ENOG4105C87 Aminotransferase class I and II FPL01_16665 ENOG4105Y38 Kinase-associated protein B FPL01_16675 ENOG4107R3E Citrate transporter FPL01_16690 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FPL01_16695 ENOG4105KA0 thioesterase Superfamily protein FPL01_16710 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FPL01_16730 ENOG41069ER domain protein FPL01_16745 ENOG4105CEP NADH dehydrogenase FPL01_16775 ENOG4105EWC Purine nucleoside phosphorylase FPL01_16785 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FPL01_16810 ENOG4108JJA ABC, transporter FPL01_16815 ENOG4105C4B ABC transporter, permease FPL01_16825 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FPL01_16850 ENOG41083MR nifu domain-containing protein FPL01_16865 ENOG4108W5N phosphatidylglycerophosphatase a FPL01_16885 ENOG4105DAX Pfam:DUF2983 FPL01_16895 ENOG4105DYS nad(p)h dehydrogenase (quinone) FPL01_16900 ENOG4105D4U had-superfamily hydrolase, subfamily iia FPL01_16915 ENOG4105CBT Fructose-1,6-bisphosphatase FPL01_16935 ENOG4105MMD transcriptional regulator FPL01_16940 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FPL01_16945 ENOG4107TXC Transcriptional regulator FPL01_16950 ENOG41090T1 Membrane FPL01_16975 ENOG4105FAA peptidase M23 FPL01_16980 ENOG4108YTE sporulation protein YunB FPL01_16985 ENOG4105KZD Domain of unknown function (DUF1805) FPL01_16990 ENOG4107R8B 5'-nucleotidase FPL01_17005 ENOG4105DIW FeS assembly protein SUFB FPL01_17010 ENOG4108UNV SUF system FeS assembly protein, NifU family FPL01_17015 ENOG4105C9B Cysteine desulfurase FPL01_17020 ENOG4105JRK feS assembly protein SufD FPL01_17025 ENOG4105C3K feS assembly ATPase SufC FPL01_17030 ENOG4105D01 (LipO)protein FPL01_17035 ENOG4105D01 (LipO)protein FPL01_17040 ENOG4108UMI ABC transporter, permease FPL01_17070 ENOG41080E8 Transcriptional regulator, Spx MgsR family FPL01_17120 ENOG4108W8B Beta-lactamase domain protein FPL01_17125 ENOG4105C1G acyl-Coa dehydrogenase FPL01_17130 ENOG4105CHU acetyl-coa acetyltransferase FPL01_17145 ENOG4105DZ1 carboxypeptidase FPL01_17165 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FPL01_17180 ENOG4108SUT Major Facilitator Superfamily FPL01_17185 ENOG4107R7I amino acid FPL01_17195 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FPL01_17205 ENOG4107AYK membrAne FPL01_17215 ENOG4105BZU Histidine kinase FPL01_17220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL01_17260 ENOG4107ZTW SNARE associated Golgi FPL01_17270 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FPL01_17280 ENOG4105BZU Histidine kinase FPL01_17300 ENOG4105C8Q Methyl-accepting chemotaxis FPL01_17305 ENOG4105C8Q Methyl-accepting chemotaxis FPL01_17310 ENOG4105VG1 fes assembly suf system protein FPL01_17315 ENOG4105D4Y metalloprotease FPL01_17340 ENOG4107S91 Sodium hydrogen exchanger FPL01_17345 ENOG4105NCW Trka-c domain protein FPL01_17355 ENOG4108RMU ferritin dps family protein FPL01_17370 ENOG4108URH decarboxylase FPL01_17390 ENOG4105D9N nucleoside FPL01_17395 ENOG4105D9N nucleoside FPL01_17410 ENOG4108RYK Nad-dependent epimerase dehydratase FPL01_17425 ENOG4105CV8 reductase FPL01_17430 ENOG4105F27 Major Facilitator FPL01_17435 ENOG4105KVH Transcriptional regulator FPL01_17450 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FPL01_17455 ENOG4105D4A Cell wall formation (By similarity) FPL01_17465 ENOG4105C8Q Methyl-accepting chemotaxis FPL01_17475 ENOG4105WMR Protein CrcB homolog FPL01_17495 ENOG4108MK9 spermidine N(1)-acetyltransferase FPL01_17510 ENOG4108IPW abc transporter atp-binding protein FPL01_17515 ENOG4105CM4 permease protein FPL01_17545 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL01_17555 ENOG4105C19 ABC transporter FPL01_17570 ENOG4107ZTW SNARE associated Golgi FPL01_17585 ENOG4108A04 Beta-lactamase FPL01_17600 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FPL01_17610 ENOG4105XZU Preprotein translocase, subunit SecG FPL01_17615 ENOG41067MG lrgb family FPL01_17665 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_17690 ENOG41090VF Stage v sporulation protein ac FPL01_17695 ENOG4105CZ3 stage V sporulation protein ad FPL01_17710 ENOG4108QY0 Membrane FPL01_17720 ENOG4105KRI phosphocarrier protein (HPr FPL01_17730 ENOG4105CHW UPF0052 protein FPL01_17740 ENOG4108Z4K mutator MutT protein FPL01_17750 ENOG4105C3M thioredoxin reductase FPL01_17760 ENOG4108S4C acetyltransferase FPL01_17780 ENOG41086DT Membrane protein of unknown function FPL01_17795 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FPL01_17815 ENOG4107TXC Transcriptional regulator FPL01_17840 ENOG4105HMI Membrane FPL01_17845 ENOG4105DUM transcriptional regulator, lysR family FPL01_17855 ENOG4108WS4 fmn reductase FPL01_17870 ENOG4105BZ1 (ABC) transporter FPL01_17880 ENOG4105CN1 protease FPL01_17885 ENOG4105CRP Part of the ABC transporter FtsEX involved in FPL01_17890 ENOG4105CAK Cell division ATP-binding protein ftsE FPL01_17910 ENOG4105MS2 ribosomal subunit Interface protein FPL01_17915 ENOG4105VEQ Cold shock protein FPL01_17920 ENOG41081UC Inherit from COG: Competence protein FPL01_17930 ENOG4105K4H Nlp p60 protein FPL01_17935 ENOG4105KVH Transcriptional regulator FPL01_17945 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FPL01_17950 ENOG4108KGH TRANSCRIPTIONal FPL01_17955 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FPL01_17960 ENOG4105C6Y Udp-glucose 6-dehydrogenase FPL01_17965 ENOG4105ESV Glycosyl transferase, family 4 FPL01_17975 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL01_17995 ENOG4105F8D glycoside hydrolase family 4 FPL01_18000 ENOG4105VCP PTS System FPL01_18005 ENOG4105CK1 PTS System FPL01_18025 ENOG4105VCP PTS System FPL01_18035 ENOG4105VZJ PTS System FPL01_18050 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FPL01_18075 ENOG4105ECB domain protein FPL01_18080 ENOG4107RSM transcriptional regulator FPL01_18130 ENOG4105DAA L-lactate FPL01_18140 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FPL01_18155 ENOG4105E0M Sulfatase FPL01_18180 ENOG4107R8N Glycosyl transferase, family 2 FPL01_18190 ENOG4105C94 Transporter FPL01_18200 ENOG41069ER domain protein FPL01_18215 ENOG4105KBK Zinc finger, swim domain protein FPL01_18220 ENOG4105C0D helicase FPL01_18250 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_18260 ENOG4107RBB ABC transporter, permease FPL01_18265 ENOG4105C19 ABC transporter FPL01_18285 ENOG4105CXY transporter FPL01_18300 ENOG4105BZU Histidine kinase FPL01_18305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_18310 ENOG4105CMR udp-glucose 4-epimerase FPL01_18320 ENOG4108KGH TRANSCRIPTIONal FPL01_18335 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FPL01_18360 ENOG4105K64 Glycosyl transferase, family 2 FPL01_18375 ENOG4105C6Y Udp-glucose 6-dehydrogenase FPL01_18390 ENOG4105D3Q Sugar transferase FPL01_18400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FPL01_18405 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FPL01_18410 ENOG4107YJ4 chain length determinant protein FPL01_18415 ENOG4105HTX biosynthesis protein FPL01_18420 ENOG4108QV3 biosynthesis protein FPL01_18435 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FPL01_18445 ENOG4105FRN stage II sporulation protein FPL01_18460 ENOG4105DY9 regulatoR FPL01_18480 ENOG4106778 Protein of unknown function (DUF1146) FPL01_18485 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL01_18490 ENOG4105C8S subunit m FPL01_18495 ENOG4105D65 subunit l FPL01_18590 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FPL01_18595 ENOG41062M3 atp synthase FPL01_18625 ENOG4108YZG isomerase FPL01_18640 ENOG4108VGI doxx family FPL01_18645 ENOG4107XC4 flavin reductase domain protein, FMN-binding FPL01_18665 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FPL01_18675 ENOG4108ZXQ stage ii sporulation protein r FPL01_18680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FPL01_18685 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FPL01_18700 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FPL01_18705 ENOG4105CBT Fructose-1,6-bisphosphatase FPL01_18710 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FPL01_18745 ENOG4105C1G acyl-Coa dehydrogenase FPL01_18750 ENOG4105C1G acyl-Coa dehydrogenase FPL01_18755 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FPL01_18765 ENOG4105DF6 Fe-S oxidoreductase FPL01_18805 ENOG4105BZU Histidine kinase FPL01_18810 ENOG4105KCT ABC transporter FPL01_18815 ENOG4108M15 ABC transporter FPL01_18820 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FPL01_18835 ENOG4105IIU Aminopeptidase FPL01_18865 ENOG410684U Domain of unknown function (DUF1934) FPL01_18890 ENOG4105CYW agmatinase FPL01_18900 ENOG4105DXB Major Facilitator superfamily FPL01_18905 ENOG4107SWG transcriptional regulator MERR family FPL01_18910 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FPL01_18915 ENOG4105BZ4 penicillin-binding protein FPL01_18920 ENOG4108XFG YwhD family FPL01_18925 ENOG4108Z4T Peptidase M50 FPL01_18930 ENOG41069HH 4-oxalocrotonate tautomerase FPL01_18935 ENOG4105DCI Phosphohydrolase FPL01_18940 ENOG4108MES Periplasmic binding protein FPL01_18945 ENOG4105E0A ABC, transporter FPL01_18950 ENOG4105EHG Permease protein FPL01_18955 ENOG4105DQ5 transport system permease protein FPL01_18965 ENOG4108VCI transcription factor, rsfa family FPL01_18975 ENOG4108IJ2 phosphate acetyltransferase FPL01_18990 ENOG4108VKI Cell wall hydrolase FPL01_19010 ENOG4107SVH Potassium channel protein FPL01_19020 ENOG410667J hydrolase FPL01_19025 ENOG4105VCH membrane FPL01_19035 ENOG4108TU7 Inherit from COG: (ABC) transporter FPL01_19040 ENOG4105CJ1 ABC, transporter FPL01_19045 ENOG41090WU lipolytic protein G-D-S-L family FPL01_19060 ENOG4105D6E homoserine dehydrogenase FPL01_19085 ENOG4108Y4K DNA-binding transcriptional activator FPL01_19100 ENOG4105WH1 Two component transcriptional regulator luxr family FPL01_19115 ENOG4105BZU Histidine kinase FPL01_19120 ENOG4105VCD cytoplasmic protein FPL01_19125 ENOG4105D22 carbon starvation protein FPL01_19130 ENOG4105DY9 regulatoR FPL01_19135 ENOG41079KZ Major Facilitator Superfamily FPL01_19150 ENOG4105CG5 Glycosyl transferase (Group 1 FPL01_19160 ENOG4105EN6 Membrane FPL01_19165 ENOG4106YBV Methyl-accepting chemotaxis FPL01_19175 ENOG4108S4H thioesterase Superfamily protein FPL01_19180 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FPL01_19195 ENOG4107S6X Glycosyl transferase, family 2 FPL01_19200 ENOG4105C5H ABC transporter FPL01_19205 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL01_19215 ENOG41067SE Tetr family transcriptional regulator FPL01_19225 ENOG4105E0X reductase FPL01_19230 ENOG4106F5Q Membrane FPL01_19245 ENOG4105DY9 regulatoR FPL01_19250 ENOG4108HRK Histidine kinase FPL01_19255 ENOG4107RGD Major Facilitator superfamily FPL01_19275 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL01_19285 ENOG4105IW1 AmiS UreI transporter FPL01_19320 ENOG4105CMR udp-glucose 4-epimerase FPL01_19325 ENOG4108UT2 hemolysin iii FPL01_19335 ENOG4105C1J atp-dependent rna helicase FPL01_19345 ENOG4105DPN Oligoendopeptidase f FPL01_19360 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FPL01_19420 ENOG4105C0H protease FPL01_19425 ENOG4105Q2H domain protein FPL01_19440 ENOG4105BZU Histidine kinase FPL01_19445 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_19485 ENOG4105BZR domain protein FPL01_19490 ENOG4108XMW Membrane FPL01_19500 ENOG4108UUM single-stranded DNA-binding protein FPL01_19510 ENOG4105C3G gtp-binding protein FPL01_19515 ENOG4105VDK protein, conserved in bacteria FPL01_19520 ENOG4105D8X mechanosensitive ion channel FPL01_19525 ENOG4108ZDA Sporulation protein YyaC FPL01_19530 ENOG4105FA0 parb-like partition protein FPL01_19535 ENOG4107QJE Chromosome Partitioning Protein FPL01_19565 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FPL01_19585 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FPL01_19590 ENOG410848D S4 domain protein YaaA FPL01_19640 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FPL01_19675 ENOG4105ZMH deoxynucleoside kinase FPL01_19685 ENOG4105GTG Isochorismatase FPL01_19700 ENOG4105C6E dna polymerase iii FPL01_19720 ENOG41067KS pro-sigma K processing FPL01_19755 ENOG4105CXN decarboxylase FPL01_19765 ENOG4105FA2 dna polymerase iii FPL01_19770 ENOG4105MA4 psp1 domain protein FPL01_19780 ENOG41060K3 Methyltransferase FPL01_19795 ENOG4105KRN Transcriptional regulator, abrb family FPL01_19805 ENOG4105F8V Hydrolase, tatD family FPL01_19810 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FPL01_19825 ENOG4105W42 Veg protein FPL01_19840 ENOG4105DFT pur operon repressor FPL01_19845 ENOG4105KME endoribonuclease L-psp FPL01_19860 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FPL01_19880 ENOG4108M14 stage v sporulation protein t FPL01_19890 ENOG4108IY2 MazG family FPL01_19895 ENOG41082I2 s4 domain protein FPL01_19900 ENOG4105VYY sporulation protein yabp FPL01_19915 ENOG41060GV RNA binding s1 domain protein FPL01_19940 ENOG4108UGV hypoxanthine phosphoribosyltransferase FPL01_19945 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FPL01_19960 ENOG4105C6T cysteine synthase FPL01_19965 ENOG4105CRQ synthase (Component I) FPL01_19970 ENOG4105DDQ anthranilate synthase FPL01_19975 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FPL01_19980 ENOG4105EEI dihydropteroate synthase FPL01_19985 ENOG4105KRF dihydroneopterin aldolase FPL01_19990 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FPL01_20000 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FPL01_20090 ENOG4108Z0C Uvrb UvrC protein FPL01_20105 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FPL01_20115 ENOG4105CTP PilT protein domain protein FPL01_20135 ENOG4105D7W serine acetyltransferase FPL01_20150 ENOG4105C2N RNA methyltransferase TrmH family group 3 FPL01_20155 ENOG4105M0M Tetracycline resistance protein FPL01_20160 ENOG4105QIV RNA polymerase FPL01_20175 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FPL01_20215 ENOG4105XPM ribosomal protein FPL01_20325 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FPL01_20350 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FPL01_20360 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL01_20370 ENOG41067V7 50S ribosomal protein L36 FPL01_20405 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FPL01_20435 ENOG4105D1F ATP-binding protein FPL01_20450 ENOG4108NMV polysaccharide deacetylase FPL01_20530 ENOG4105C8B TIGR00159 family FPL01_20535 ENOG4107U5W ybbr family FPL01_20595 ENOG4108PSK reductase FPL01_20610 ENOG4105IQ5 FAD linked oxidase domain protein FPL01_20625 ENOG4105C2C drug resistance transporter, Bcr CflA FPL01_20645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FPL01_20650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL01_20655 ENOG4105C3U ABC transporter FPL01_20660 ENOG4108JQ7 (ABC) transporter FPL01_20680 ENOG4105U5Y Transcriptional regulator FPL01_20690 ENOG4108J59 Extracellular solute-binding protein, family 5 FPL01_20695 ENOG4108J59 Extracellular solute-binding protein, family 5 FPL01_20710 ENOG4107XDY Nicotinamide Mononucleotide Transporter FPL01_20720 ENOG4105E0C molybdate abc transporter FPL01_20725 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FPL01_20730 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FPL01_20760 ENOG4105F6E Acyl-transferase FPL01_20780 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FPL01_20790 ENOG4108RE7 deoxyribonuclease FPL01_20800 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FPL01_20820 ENOG4105C5H ABC transporter FPL01_20830 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FPL01_20835 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FPL01_20845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL01_20850 ENOG4105C3U ABC transporter FPL01_20855 ENOG4108JQ7 (ABC) transporter FPL01_20860 ENOG410667J hydrolase FPL01_20895 ENOG4105ERH Fumarylacetoacetate hydrolase FPL01_20905 ENOG4105CUB amino acid FPL01_20915 ENOG4105CPF Cell wall formation (By similarity) FPL01_20920 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FPL01_20945 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FPL01_20960 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FPL01_21060 ENOG4105K8N protein family UPF0079, ATPase FPL01_21065 ENOG41072GX Peptidase M22 Glycoprotease FPL01_21070 ENOG410801F ribosomal-protein-alanine acetyltransferase FPL01_21080 ENOG4105C5H ABC transporter FPL01_21095 ENOG4108TYN CAAX amino terminal protease family protein FPL01_21135 ENOG4107QZI cell division protein FtsK FPL01_21145 ENOG4106128 DNA-binding helix-turn-helix protein FPL01_21160 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FPL01_21170 ENOG4105C7N Xanthine uracil vitamin C permease FPL01_21180 ENOG4105BZU Histidine kinase FPL01_21210 ENOG4107ZXU DSBA oxidoreductase FPL01_21240 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL01_21260 ENOG4108SHN Glycosyl transferase, family 2 FPL01_21285 ENOG4105DUM transcriptional regulator, lysR family FPL01_21315 ENOG4105SX7 Transporter FPL01_21340 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FPL01_21345 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FPL01_21350 ENOG4105C83 adenylosuccinate lyase FPL01_21360 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FPL01_21385 ENOG4108V3E phosphoribosylglycinamide formyltransferase FPL01_21395 ENOG4105C12 Phosphoribosylglycinamide synthetase FPL01_21425 ENOG4105C4R Atp-dependent dna helicase FPL01_21450 ENOG4108W2Y isochorismatase FPL01_21460 ENOG4108UMI ABC transporter, permease FPL01_21465 ENOG4105D01 (LipO)protein FPL01_21485 ENOG410834F Transcriptional regulator FPL01_21490 ENOG4107I77 yiaA/B two helix domain FPL01_21510 ENOG4105CBD Diacylglycerol kinase FPL01_21515 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FPL01_21520 ENOG4108JPW Aminotransferase FPL01_21530 ENOG4105C26 Dehydrogenase FPL01_21535 ENOG4105KPY Small multidrug resistance protein FPL01_21555 ENOG4105D9N nucleoside FPL01_21560 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FPL01_21580 ENOG4108W15 Protein of unknown function (DUF1456) FPL01_21595 ENOG4105DTQ mandelate racemase muconate lactonizing FPL01_21605 ENOG4105DFD Na H antiporter FPL01_21630 ENOG4105D3R alkyl hydroperoxide reductase FPL01_21650 ENOG4107W7X Aldolase FPL01_21655 ENOG4105EHG Permease protein FPL01_21660 ENOG4105DQ5 transport system permease protein FPL01_21665 ENOG4108V5C ABC transporter FPL01_21695 ENOG4106UIA FPL01_21700 ENOG4106UIA FPL01_21730 ENOG410756H nucleotidyltransferase FPL01_21735 ENOG4105D2S major facilitator superfamily FPL01_21750 ENOG4105E5Q amino acid AbC transporter FPL01_21755 ENOG4105EAB amino acid AbC transporter FPL01_21765 ENOG4105C8Q Methyl-accepting chemotaxis FPL01_21790 ENOG4105C5B carbamate kinase FPL01_21795 ENOG4108W63 CRP FNR family transcriptional regulator FPL01_21805 ENOG4105DNP FAD linked oxidase domain protein FPL01_21815 ENOG4105CI1 PTS System FPL01_21835 ENOG4105CJA serine threonine protein kinase FPL01_21845 ENOG4105BZ1 (ABC) transporter FPL01_21870 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FPL01_21885 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FPL01_21905 ENOG4105C5H ABC transporter FPL01_21935 ENOG41062JF Transcriptional regulator FPL01_21955 ENOG4105DEU major facilitator superfamily FPL01_21985 ENOG4108N0M stress protein FPL01_21990 ENOG4106FN3 tellurium resistance protein FPL01_21995 ENOG4106FN3 tellurium resistance protein FPL01_22000 ENOG4107TS3 membrane protein, TerC FPL01_22005 ENOG4108TTB tellurium resistance protein FPL01_22025 ENOG4105KJF protein tyrosine phosphatase FPL01_22035 ENOG4107U9T Pfam:Ribonuclease_BN FPL01_22045 ENOG4108IPJ Membrane FPL01_22060 ENOG4105C3F Signal peptidase i FPL01_22070 ENOG4107ZTW SNARE associated Golgi FPL01_22085 ENOG410606W general stress protein FPL01_22090 ENOG4105UPD Calcium Proton FPL01_22140 ENOG4108JUB Transcriptional regulator FPL01_22150 ENOG4108IQI permease FPL01_22175 ENOG4105CSV Glutaminase FPL01_22200 ENOG4105CKK Glycosyl transferase, family 2 FPL01_22205 ENOG4107QQG Dehydrogenase FPL01_22210 ENOG4105C3I Nad-dependent epimerase dehydratase FPL01_22225 ENOG4105F1A Pyruvate formate-lyase FPL01_22245 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FPL01_22250 ENOG4105ECP epimerase FPL01_22285 ENOG4105CEN a g-specific adenine glycosylase FPL01_22290 ENOG4106BXE FPL01_22310 ENOG4105BZ1 (ABC) transporter FPL01_22315 ENOG4107NBY Membrane FPL01_22320 ENOG4105CBC glutamate synthase FPL01_22330 ENOG4108IUW ABC transporter FPL01_22350 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL01_22355 ENOG4105G5W regulator Fur family FPL01_22470 ENOG4108JQC penicillin-binding protein 1A FPL01_22475 ENOG4107ZQN disulfide bond FPL01_22485 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FPL01_22495 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FPL01_22500 ENOG4105BZU Histidine kinase FPL01_22505 ENOG4105CYN Serine protein kinase FPL01_22520 ENOG4108MK9 spermidine N(1)-acetyltransferase FPL01_22525 ENOG4105C94 Transporter FPL01_22540 ENOG4105DZ6 Band 7 protein FPL01_22550 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FPL01_22555 ENOG4108V9W transcriptional regulatory protein FPL01_22560 ENOG4105D4T Citrate transporter FPL01_22585 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FPL01_22590 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FPL01_22595 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FPL01_22600 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FPL01_22605 ENOG4105BZ7 extracellular solute-binding protein family 1 FPL01_22615 ENOG4108STX response regulator FPL01_22620 ENOG4105US7 Histidine kinase FPL01_22645 ENOG4108MRH transcriptional regulatory protein FPL01_22655 ENOG4105C6K Malic enzyme FPL01_22665 ENOG4108UZ3 Transporter FPL01_22670 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL01_22680 ENOG4105BZU Histidine kinase FPL01_22685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_22690 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FPL01_22695 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FPL01_22700 ENOG4108JB9 formate dehydrogenase FPL01_22720 ENOG4105CUB amino acid FPL01_22730 ENOG4105C59 p-type ATPase FPL01_22735 ENOG4105DAP Nicotinate phosphoribosyltransferase FPL01_22770 ENOG41073R8 VanW family FPL01_22775 ENOG4108KGH TRANSCRIPTIONal FPL01_22780 ENOG4105D9N nucleoside FPL01_22785 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FPL01_22790 ENOG4105C37 (CBS) domain FPL01_22795 ENOG4108IJ0 Aspartate ammonia-lyase FPL01_22800 ENOG4105DAA L-lactate FPL01_22815 ENOG4105DUX Transporter FPL01_22820 ENOG4108MES Periplasmic binding protein FPL01_22825 ENOG4105DQ5 transport system permease protein FPL01_22830 ENOG4108IHU transport system permease protein FPL01_22835 ENOG4105E0A ABC, transporter FPL01_22840 ENOG4105DMQ Methyltransferase FPL01_22850 ENOG4105EXW epimerase dehydratase FPL01_22855 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FPL01_22865 ENOG4107T89 von Willebrand factor, type A FPL01_22870 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FPL01_22890 ENOG4105BZU Histidine kinase FPL01_22895 ENOG4105D5Q Arginine ornithine antiporter FPL01_22900 ENOG4107414 GntR family transcriptional regulator FPL01_22905 ENOG4105C5Y PTS System FPL01_22925 ENOG4105E1K spore germination protein FPL01_22935 ENOG4105CRN Aminoglycoside phosphotransferase FPL01_22940 ENOG4105BZG amino acid carrier protein FPL01_22945 ENOG4105CDA abc transporter atp-binding protein FPL01_22950 ENOG4105CT1 (ABC) transporter FPL01_22955 ENOG4105EAD ABC transporter FPL01_22960 ENOG4105DRP amino acid AbC transporter FPL01_22965 ENOG4108IQI permease FPL01_22980 ENOG4108WQI RNA Polymerase FPL01_23000 ENOG4105BZU Histidine kinase FPL01_23030 ENOG41068KF Universal stress protein FPL01_23040 ENOG4105DEF Extracellular solute-binding protein, family 5 FPL01_23050 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FPL01_23055 ENOG4108JQ7 (ABC) transporter FPL01_23065 ENOG4105CXY transporter FPL01_23070 ENOG41067TZ transcriptional regulator, MarR family FPL01_23075 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL01_23080 ENOG4105ETE Transcriptional regulator (LacI family FPL01_23085 ENOG4108RVA ribokinase FPL01_23100 ENOG4105CNN ABC, transporter FPL01_23105 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FPL01_23110 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FPL01_23170 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FPL01_23175 ENOG41069ER domain protein FPL01_23180 ENOG4105VZ8 Transcriptional regulator FPL01_23185 ENOG4107D63 FPL01_23195 ENOG4105DUX Transporter FPL01_23215 ENOG4105C85 amino acid FPL01_23220 ENOG4105C7N Xanthine uracil vitamin C permease FPL01_23260 ENOG4105BZ9 Cytochrome C oxidase, subunit I FPL01_23265 ENOG4105E2S oxidase) subunit II FPL01_23285 ENOG4106CAD Protein of unknown function (DUF3311) FPL01_23290 ENOG4105E1V na solute symporter FPL01_23310 ENOG4105CE1 Ferrous iron transport protein b FPL01_23315 ENOG4105CE1 Ferrous iron transport protein b FPL01_23320 ENOG4105CE1 Ferrous iron transport protein b FPL01_23325 ENOG4105CVA phosphate FPL01_23330 ENOG4105C8U phosphate abc transporter FPL01_23335 ENOG4105E2Z phosphate ABC transporter (Permease FPL01_23465 ENOG41080XQ Signal transduction protein with cbs domains FPL01_23485 ENOG4105ETU transcriptional activator (TenA FPL01_23495 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FPL01_23505 ENOG4108VEU Thiamine monophosphate synthase FPL01_23510 ENOG41080HI glycine oxidase FPL01_23525 ENOG4105D06 uba thif-type nad fad binding protein FPL01_23530 ENOG4105DWF phosphomethylpyrimidine kinase FPL01_23580 ENOG4108INS Transcriptional regulator FPL01_23595 ENOG4105C7N Xanthine uracil vitamin C permease FPL01_23640 ENOG4108B31 Spore germination protein FPL01_23660 ENOG4107Y03 Nitroreductase FPL01_23665 ENOG4105ED1 spovr family FPL01_23675 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FPL01_23680 ENOG4105XTG Pfam:DUF156 FPL01_23685 ENOG4105VFE sira family FPL01_23690 ENOG4107TPS domain protein FPL01_23695 ENOG4105VFE sira family FPL01_23700 ENOG41085GJ domain protein FPL01_23710 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FPL01_23715 ENOG41087NI Sulfite exporter TauE/SafE FPL01_23725 ENOG4108KGH TRANSCRIPTIONal FPL01_23780 ENOG4105VCP PTS System FPL01_23785 ENOG4105VZJ PTS System FPL01_23805 ENOG41069ER domain protein FPL01_23810 ENOG4107RBB ABC transporter, permease FPL01_23815 ENOG4105C19 ABC transporter FPL01_23845 ENOG4105WEF catalase FPL01_23880 ENOG4107T5V SNARE associated Golgi FPL01_23910 ENOG4105CUB amino acid FPL01_23915 ENOG4107RWR Sodium hydrogen exchanger FPL01_23925 ENOG4106KNT transcriptional regulator FPL01_23965 ENOG4108YXU transcriptional regulator AsnC family FPL01_23985 ENOG4105KPY Small multidrug resistance protein FPL01_23990 ENOG4105KPY Small multidrug resistance protein FPL01_24035 ENOG4105C19 ABC transporter FPL01_24040 ENOG4107RBB ABC transporter, permease FPL01_24045 ENOG4105C19 ABC transporter FPL01_24075 ENOG4105NF4 modulator of drug activity FPL01_24085 ENOG4105E5W Transporter FPL01_24095 ENOG4107RKG DJ-1/PfpI family FPL01_24100 ENOG4105CH6 catalase FPL01_24110 ENOG4105D5Q Arginine ornithine antiporter FPL01_24115 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FPL01_24120 ENOG4105C26 Dehydrogenase FPL01_24135 ENOG4105BZ1 (ABC) transporter FPL01_24145 ENOG4105DRP amino acid AbC transporter FPL01_24150 ENOG4105CDA abc transporter atp-binding protein FPL01_24165 ENOG410839P FPL01_24200 ENOG4107FQX Alpha-acetolactate decarboxylase FPL01_24230 ENOG4105D4P Coproporphyrinogen iii oxidase FPL01_24250 ENOG4105CHH sulfate transporter FPL01_24285 ENOG4106AKK s-layer domain-containing protein FPL01_24295 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL01_24300 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL01_24315 ENOG4105CGU Enoyl-CoA hydratase FPL01_24330 ENOG4105DER m42 family FPL01_24380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL01_24390 ENOG4108JQ7 (ABC) transporter FPL01_24410 ENOG4105CSH Transporter FPL01_24420 ENOG4108MRH transcriptional regulatory protein FPL01_24490 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FPL01_24515 ENOG4105CDU Replicative dna helicase FPL01_24580 ENOG4105CID antiterminator FPL01_24600 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL01_24625 ENOG4105CMT Dihydroxyacetone kinase FPL01_24640 ENOG4105CMT Dihydroxyacetone kinase FPL01_24695 ENOG4106AKK s-layer domain-containing protein FPL01_24750 ENOG4105WN5 stage II sporulation protein FPL01_24760 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL01_24770 ENOG4108MJI response regulator FPL01_24775 ENOG4105BZU Histidine kinase FPL01_24800 ENOG4105K8R UPF0145 protein FPL01_24825 ENOG4105EQ0 Major Facilitator superfamily FPL01_24850 ENOG4107VRP DNA repair exonuclease FPL01_24895 ENOG4108MUZ hydrolase FPL01_24905 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FPL01_24920 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FPL01_24925 ENOG4105EMN RNA polymerase sigma factor FPL01_24950 ENOG4105EEM helicase FPL01_25010 ENOG4106F1P AAA ATPase, central domain protein FPL01_25015 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL01_25040 ENOG4105K59 histidine triad (HIT) protein FPL01_25070 ENOG410905X membrane-flanked domain protein FPL01_25075 ENOG4105CKV Membrane FPL01_25095 ENOG410905X membrane-flanked domain protein FPL01_25100 ENOG4105CKV Membrane FPL01_25105 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FPL01_25110 ENOG4105BZ4 penicillin-binding protein FPL01_25120 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FPL01_25125 ENOG4105C1Q protoporphyrinogen oxidase FPL01_25150 ENOG4105NA0 Transcriptional regulator FPL01_25165 ENOG4105ECB domain protein FPL01_25195 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FPL01_25200 ENOG4106DF1 FPL01_25205 ENOG4105D29 Helix-turn-helix type 11 domain protein FPL01_25215 ENOG4106AXD FPL01_25220 ENOG4108RQ5 Beta-lactamase domain-containing protein FPL01_25225 ENOG4105DF9 Lipoate-protein, ligase FPL01_25235 ENOG4105CEY Amp-dependent synthetase and ligase FPL01_25240 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FPL01_25245 ENOG4108I5D sulfate abc transporter FPL01_25250 ENOG4105ECW sulfate abc transporter FPL01_25260 ENOG4105CNA YD repeat protein FPL01_25315 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) FPL01_25325 ENOG4105ENX hydrolase FPL01_25335 ENOG4107TVP HD domain protein FPL01_25345 ENOG4105C57 major facilitator superfamily FPL01_25360 ENOG41086D8 Transcriptional regulator FPL01_25370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL01_25390 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FPL01_25410 ENOG4105ZU5 s-layer protein FPL01_25415 ENOG4107QP3 malate synthase g FPL01_25435 ENOG4105VEQ Cold shock protein FPL01_25560 ENOG4105CAQ asparagine synthetase FPL01_25570 ENOG4105CH6 catalase FPL01_25610 ENOG4105BZU Histidine kinase FPL01_25635 ENOG4105QNR S1 RNA binding domain protein FPL01_25640 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL01_25650 ENOG4107AYK membrAne FPL01_25655 ENOG41073B9 FPL01_25665 ENOG4108KP7 hydrolase FPL01_25705 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FPL01_25710 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FPL01_25730 ENOG4105C31 Tryptophanyl-tRNA synthetase FPL01_25750 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FPL01_25755 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL01_25765 ENOG4108JQ7 (ABC) transporter FPL01_25770 ENOG4105UQX Mate efflux family protein FPL01_25790 ENOG4108ZCF integral membrane protein FPL01_25800 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL01_25810 ENOG4105DPN Oligoendopeptidase f FPL01_25820 ENOG4108Z18 K06886 hemoglobin FPL01_25825 ENOG4105MIX Adenylate cyclase FPL01_25830 ENOG4106EFP UPF0738 protein FPL01_25845 ENOG4105EMS pseudouridine synthase FPL01_25865 ENOG4105K64 Glycosyl transferase, family 2 FPL01_25885 ENOG4107TVC Glycosyl transferase, family 2 FPL01_25905 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FPL01_25910 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FPL01_25920 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FPL01_26005 ENOG4105CK7 Sodium proline symporter FPL01_26015 ENOG4105CRQ synthase (Component I) FPL01_26020 ENOG4105DDQ anthranilate synthase FPL01_26100 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL01_26120 ENOG4105C7S Dehydrogenase FPL01_26130 ENOG4105VZ8 Transcriptional regulator FPL01_26225 ENOG4105VTR Integrase FPL01_26250 ENOG4105DZ1 carboxypeptidase FPL01_26255 ENOG4105VFR signal peptidase FPL01_26290 ENOG4105C26 Dehydrogenase FPL01_26300 ENOG4105F38 ABC transporter, permease FPL01_26305 ENOG4105D38 putrescine abc transporter FPL01_26310 ENOG4107RUE extracellular solute-binding protein family 1 FPL01_26320 ENOG4105EYF MMPL domain protein FPL01_26330 ENOG4108YBP pseudouridine synthase FPL01_26345 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FPL01_26350 ENOG4105CQB FAD linked oxidase domain protein FPL01_26365 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_26370 ENOG4105BZU Histidine kinase FPL01_26375 ENOG4105JXH GntR family transcriptional regulator FPL01_26395 ENOG4106A3R peptidase FPL01_26405 ENOG4108QTI )-transporter FPL01_26410 ENOG4107TS3 membrane protein, TerC FPL01_26415 ENOG4105CZN Potassium uptake protein FPL01_26420 ENOG410681C small acid-soluble spore protein FPL01_26445 ENOG4105CHR reductase FPL01_26475 ENOG4105C4Y ABC transporter FPL01_26485 ENOG4107RCV ABC transporter, permease FPL01_26505 ENOG4105E98 transcriptional regulator DeoR family FPL01_26515 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FPL01_26535 ENOG4105BZU Histidine kinase FPL01_26540 ENOG41090MY MarR family Transcriptional regulator FPL01_26560 ENOG4105BZU Histidine kinase FPL01_26570 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FPL01_26575 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FPL01_26620 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FPL01_26645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FPL01_26650 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FPL01_26655 ENOG4105CZV ABC transporter FPL01_26665 ENOG4105CJ1 ABC, transporter FPL01_26705 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FPL01_26710 ENOG4105EA8 2-Nitropropane dioxygenase FPL01_26715 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FPL01_26725 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL01_26750 ENOG4105NQC Flavodoxin FPL01_26815 ENOG4105CZN Potassium uptake protein FPL01_26820 ENOG41063Y9 FPL01_26825 ENOG4105KBJ sporulation protein ytfj FPL01_26845 ENOG4105CM2 brancheD-chain amino acid aminotransferase FPL01_26850 ENOG4105C7K acetolactate synthase FPL01_26855 ENOG4108ZP8 Acetolactate synthase small subunit FPL01_26930 ENOG4107RVV histidinol phosphate phosphatase, hisj family FPL01_26945 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL01_26950 ENOG4105E0M Sulfatase FPL01_26960 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FPL01_26980 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FPL01_26985 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FPL01_26995 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FPL01_27000 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FPL01_27005 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FPL01_27010 ENOG4105C8J )-transporter FPL01_27030 ENOG4105DFD Na H antiporter FPL01_27050 ENOG4105ENE Histidine kinase FPL01_27055 ENOG4105WH1 Two component transcriptional regulator luxr family FPL01_27075 ENOG41089UC methyltransferase, type 11 FPL01_27115 ENOG4105CJ3 phosphate transporter FPL01_27120 ENOG4107GRR phosphate transport regulator FPL01_27145 ENOG4105BZU Histidine kinase FPL01_27150 ENOG4105I3N Conserved Protein FPL01_27165 ENOG4105BZU Histidine kinase FPL01_27200 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL01_27205 ENOG4105DZ1 carboxypeptidase FPL01_27210 ENOG4108JIC nucleoside recognition domain protein FPL01_27220 ENOG4105FE9 pseudouridine synthase FPL01_27230 ENOG4107TWT Cytochrome c biogenesis protein FPL01_27235 ENOG4105CRE cytochrome C FPL01_27240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL01_27245 ENOG4105BZU Histidine kinase FPL01_27250 ENOG4108WBT adenosyltransferase FPL01_27255 ENOG41063SB peptidase FPL01_27265 ENOG4108SAX Membrane FPL01_27280 ENOG4105C9U ATP-dependent DNA helicase RecQ FPL01_27295 ENOG4107RGJ metallophosphoesterase FPL01_27300 ENOG4107X2D transcriptional regulator, merr family FPL01_27305 ENOG4108S6Z Negative regulator of genetic competence FPL01_27330 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FPL01_27335 ENOG4105HDK L-asparaginase FPL01_27365 ENOG4105S2F FPL01_27370 ENOG41065D1 FPL01_27400 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FPL01_27415 ENOG4105XXQ heptaprenyl diphosphate synthase component I FPL01_27425 ENOG4105EAH synthase FPL01_27450 ENOG41068YB TPR repeat-containing protein FPL01_27465 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FPL01_27470 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FPL01_27505 ENOG4108JYZ YitT family FPL01_27515 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FPL01_27530 ENOG4105FJR Lmbe family FPL01_27535 ENOG4105CPK Glycosyl transferase (Group 1 FPL01_27570 ENOG4105DVT helicase FPL01_27575 ENOG4105YAC FPL01_27595 ENOG4105CSM endonuclease III FPL01_27660 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FPL01_27670 ENOG4105DVT helicase FPL01_27685 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL01_27695 ENOG4105C2W permease FPL01_27700 ENOG4105DHF Membrane FPL01_27705 ENOG410890F Dynamin family FPL01_27715 ENOG4108W0I acetyltransferase FPL01_27725 ENOG4105KHC sulfurtransferase FPL01_27760 ENOG4108SZE gCN5-related N-acetyltransferase FPL01_27845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL01_27855 ENOG4107RWR Sodium hydrogen exchanger FPL01_27860 ENOG4105CN5 Metallo-Beta-Lactamase FPL01_27865 ENOG4108Z5V transcriptional regulator, merr family FPL01_27875 ENOG4105H67 Protein of unknown function (DUF421) FPL01_27880 ENOG41080C8 DUF218 domain FPL01_27915 ENOG4107Y80 Major Facilitator superfamily FPL01_27945 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FPL01_27955 ENOG4107R0U MotA TolQ exbB proton channel FPL01_27960 ENOG4105ER2 Ompa motb domain protein FPL01_27965 ENOG4107YTP response regulator receiver protein FPL01_27970 ENOG4105CBS Chea signal transduction histidine kinase FPL01_27975 ENOG4105DD5 Flagellar motor switch protein FPL01_27990 ENOG4105BZU Histidine kinase FPL01_28010 ENOG4105E1Q flagellar hook-associated protein FPL01_28015 ENOG4105DTJ flagellar hook-associated protein FPL01_28020 ENOG4107TPX flagellar hook-associated FPL01_28035 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FPL01_28040 ENOG4108ZC9 flagellar basal-body rod protein flgc FPL01_28045 ENOG41075Z6 flagellar hook-basal body complex protein fliE FPL01_28050 ENOG4107U2N Flagellar M-ring protein FPL01_28055 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FPL01_28085 ENOG4105BZE flagellar hook protein, FlgE FPL01_28110 ENOG4105I03 Flagellin FPL01_28115 ENOG4105I03 Flagellin FPL01_28120 ENOG4105E4C Lytic transglycosylase catalytic FPL01_28130 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FPL01_28135 ENOG4105DD5 Flagellar motor switch protein FPL01_28145 ENOG4105CN7 Flagellar biosynthetic protein FliP FPL01_28150 ENOG4105VS8 Flagellar biosynthetic protein fliq FPL01_28160 ENOG4105D00 flagellar biosynthetic protein flhB FPL01_28165 ENOG4105D7B Flagellar biosynthesis protein flha FPL01_28175 ENOG4105KTQ flagellar basal-body rod protein FPL01_28180 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FPL01_28205 ENOG4108RZE Tetr family transcriptional regulator FPL01_28225 ENOG4105KAC Antibiotic biosynthesis monooxygenase FPL01_28245 ENOG4108U4N (sortase) family FPL01_28270 ENOG4105DUM transcriptional regulator, lysR family FPL01_28275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FPL01_28285 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FPL01_28290 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FPL01_28305 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FPL01_28350 ENOG4105K56 Transcriptional regulator FPL01_28385 ENOG4105PGM cation diffusion facilitator family transporter FPL01_28395 ENOG4105DRR Transcriptional regulator, GntR family FPL01_28400 ENOG4108UZ3 Transporter FPL01_28405 ENOG4105CKI cobalamin synthesis protein FPL01_28425 ENOG4105DFD Na H antiporter FPL01_28435 ENOG4105C9Q fumarate hydratase class II FPL01_28455 ENOG4107QJQ Mate efflux family protein FPL01_28460 ENOG4105EC3 peptidase S51, dipeptidase E FPL01_28540 ENOG4105CJ1 ABC, transporter