locus-tag class description FLQ07_00015 ENOG4108VDD TRNA binding domain protein FLQ07_00030 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FLQ07_00045 ENOG4105C6K Malic enzyme FLQ07_00050 ENOG4105C8F Beta-lactamase domain protein FLQ07_00055 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FLQ07_00065 ENOG4108V15 phosphotransferase enzyme family FLQ07_00070 ENOG4108IUM Glycogen debranching enzyme FLQ07_00085 ENOG4107F58 2'-5' rna ligase FLQ07_00090 ENOG4105C6T cysteine synthase FLQ07_00105 ENOG4107QSE Dipeptidase FLQ07_00110 ENOG4105C7N Xanthine uracil vitamin C permease FLQ07_00125 ENOG4105YW5 deoR family transcriptional regulator FLQ07_00140 ENOG4105CBX hi0933 family FLQ07_00145 ENOG4105C94 Transporter FLQ07_00155 ENOG41085GJ domain protein FLQ07_00170 ENOG4105MU9 integral membrane protein FLQ07_00175 ENOG4105DDC Oxidoreductase domain protein FLQ07_00185 ENOG4105F5H Glycosyl Hydrolase Family 88 FLQ07_00195 ENOG41075H3 AraC family transcriptional regulator FLQ07_00205 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FLQ07_00215 ENOG4105NTD Inherit from COG: Hydrolase FLQ07_00225 ENOG4107V2S Transcriptional regulator FLQ07_00230 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ07_00235 ENOG4105C8T Leucyl-tRNA synthetase FLQ07_00245 ENOG410605W Major Facilitator FLQ07_00250 ENOG4105D01 (LipO)protein FLQ07_00255 ENOG4106UBQ FLQ07_00260 ENOG4107R34 abc transporter permease protein FLQ07_00265 ENOG4105C19 ABC transporter FLQ07_00275 ENOG4105DVE abc transporter atp-binding protein FLQ07_00280 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FLQ07_00290 ENOG4105N5T Radical SAM Protein FLQ07_00310 ENOG4105E8V Alpha Beta Hydrolase Fold protein FLQ07_00315 ENOG4108Z0R Transferase FLQ07_00320 ENOG4105YVM Phosphoesterase, PA-phosphatase related FLQ07_00325 ENOG4105BZF Glycosyl transferase (Group 1 FLQ07_00330 ENOG4105CAQ asparagine synthetase FLQ07_00335 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FLQ07_00345 ENOG4105CK2 sodium dicarboxylate symporter FLQ07_00360 ENOG4105D2X ABC transporter substrate-binding protein FLQ07_00370 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FLQ07_00390 ENOG4108RMU ferritin dps family protein FLQ07_00405 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FLQ07_00410 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FLQ07_00415 ENOG4108V2W Carbonate dehydratase FLQ07_00420 ENOG4105CKI cobalamin synthesis protein FLQ07_00425 ENOG4105DSE periplasmic solute binding protein FLQ07_00460 ENOG4105DTQ mandelate racemase muconate lactonizing FLQ07_00465 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_00470 ENOG4108IPT Naphthoate synthase FLQ07_00475 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FLQ07_00480 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FLQ07_00485 ENOG4105E4F Isochorismate synthase FLQ07_00490 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FLQ07_00505 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) FLQ07_00515 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) FLQ07_00520 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) FLQ07_00645 ENOG4105CMD Transcriptional regulator, GntR family FLQ07_00650 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FLQ07_00675 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) FLQ07_00685 ENOG4105CZN Potassium uptake protein FLQ07_00695 ENOG4106DF1 FLQ07_00700 ENOG4108VNY MOSC domain protein FLQ07_00705 ENOG4108JB8 alcohol dehydrogenase FLQ07_00710 ENOG4105C26 Dehydrogenase FLQ07_00715 ENOG4105TRT Transcriptional regulator FLQ07_00725 ENOG4105JQZ Methyltransferase FLQ07_00730 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FLQ07_00735 ENOG4105F0F Oxalate decarboxylase FLQ07_00745 ENOG41065RQ ADP-ribosylation crystallin J1 FLQ07_00800 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) FLQ07_00825 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FLQ07_00835 ENOG4105EE0 oxidoreductase FLQ07_00840 ENOG4108Z0Z intracellular protease Pfpi family FLQ07_00845 ENOG4105C8Q Methyl-accepting chemotaxis FLQ07_00855 ENOG4105C8Q Methyl-accepting chemotaxis FLQ07_00865 ENOG4105EA8 2-Nitropropane dioxygenase FLQ07_00870 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FLQ07_00895 ENOG4105C37 (CBS) domain FLQ07_00910 ENOG4107PBV potassium channel FLQ07_00915 ENOG4107PBV potassium channel FLQ07_00925 ENOG410900G Protein of unknown function (DUF421) FLQ07_00935 ENOG4105KNA -acetyltransferase FLQ07_00940 ENOG4107QYV phosphohexose isomerase FLQ07_00945 ENOG4107QW4 alcohol dehydrogenase FLQ07_00950 ENOG4105WG9 Conserved Protein FLQ07_00960 ENOG4105CHM Aminotransferase FLQ07_00965 ENOG4108ZB6 transcriptional regulator AsnC family FLQ07_00970 ENOG4108MUZ hydrolase FLQ07_00985 ENOG4105C87 Aminotransferase class I and II FLQ07_00995 ENOG4105Y38 Kinase-associated protein B FLQ07_01010 ENOG4105BZ4 penicillin-binding protein FLQ07_01015 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FLQ07_01030 ENOG4108MRH transcriptional regulatory protein FLQ07_01035 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FLQ07_01040 ENOG4107ZTW SNARE associated Golgi FLQ07_01045 ENOG4105DJ4 phosphatidylserine decarboxylase FLQ07_01060 ENOG4105D65 subunit l FLQ07_01065 ENOG4105HC0 Na H antiporter FLQ07_01070 ENOG4108ZE9 Monovalent cation H antiporter subunit C FLQ07_01075 ENOG4108JPZ Monovalent cation H antiporter subunit D FLQ07_01080 ENOG4105SC1 monovalent cation H antiporter subunit E FLQ07_01090 ENOG4105KJM monovalent cation h antiporter subunit g FLQ07_01095 ENOG4105KA0 thioesterase Superfamily protein FLQ07_01105 ENOG4105BZU Histidine kinase FLQ07_01135 ENOG4105D58 Diguanylate phosphodiesterase FLQ07_01140 ENOG4105DAP Nicotinate phosphoribosyltransferase FLQ07_01165 ENOG4105C02 permease FLQ07_01180 ENOG410904N short-chain dehydrogenase reductase FLQ07_01220 ENOG4105BZG amino acid carrier protein FLQ07_01225 ENOG4108K8K Transcriptional regulator FLQ07_01230 ENOG4105DCF alanine dehydrogenase FLQ07_01255 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FLQ07_01265 ENOG41069ER domain protein FLQ07_01275 ENOG4105CEP NADH dehydrogenase FLQ07_01280 ENOG4105CAY ferredoxin--nadp reductase FLQ07_01295 ENOG4108YM7 Gcn5-related n-acetyltransferase FLQ07_01420 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FLQ07_01445 ENOG4108ZMX Domain of unknown function (DU1801) FLQ07_01465 ENOG4105PY6 Phenolic acid decarboxylase FLQ07_01480 ENOG41083MR nifu domain-containing protein FLQ07_01485 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FLQ07_01490 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) FLQ07_01495 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FLQ07_01500 ENOG4105D6E homoserine dehydrogenase FLQ07_01505 ENOG4105C5I Dehydrogenase FLQ07_01515 ENOG4108W5N phosphatidylglycerophosphatase a FLQ07_01520 ENOG4105D4U had-superfamily hydrolase, subfamily iia FLQ07_01530 ENOG4105MMD transcriptional regulator FLQ07_01535 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FLQ07_01540 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) FLQ07_01545 ENOG4105FAA peptidase M23 FLQ07_01555 ENOG4105C8J )-transporter FLQ07_01560 ENOG4108YTE sporulation protein YunB FLQ07_01565 ENOG4105KZD Domain of unknown function (DUF1805) FLQ07_01570 ENOG4107R8B 5'-nucleotidase FLQ07_01580 ENOG4105I3N Conserved Protein FLQ07_01585 ENOG4105IIP Membrane FLQ07_01590 ENOG4105W1N transcriptional regulator FLQ07_01595 ENOG4105C5R Aminotransferase FLQ07_01600 ENOG4105G9B Transcriptional regulator FLQ07_01625 ENOG4108K8S endonuclease I FLQ07_01635 ENOG4107VFR oxidoreductase FLQ07_01660 ENOG4105DIW FeS assembly protein SUFB FLQ07_01665 ENOG4108UNV SUF system FeS assembly protein, NifU family FLQ07_01670 ENOG4105C9B Cysteine desulfurase FLQ07_01675 ENOG4105JRK feS assembly protein SufD FLQ07_01680 ENOG4105C3K feS assembly ATPase SufC FLQ07_01685 ENOG4105PGM cation diffusion facilitator family transporter FLQ07_01695 ENOG4105D01 (LipO)protein FLQ07_01700 ENOG4108UMI ABC transporter, permease FLQ07_01705 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FLQ07_01730 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FLQ07_01735 ENOG41080E8 Transcriptional regulator, Spx MgsR family FLQ07_01740 ENOG4105C1G acyl-Coa dehydrogenase FLQ07_01745 ENOG4105CHU acetyl-coa acetyltransferase FLQ07_01780 ENOG4105E0A ABC, transporter FLQ07_01785 ENOG4108IHU transport system permease protein FLQ07_01790 ENOG4105DQ5 transport system permease protein FLQ07_01795 ENOG4108MES Periplasmic binding protein FLQ07_01810 ENOG4105DZ1 carboxypeptidase FLQ07_01815 ENOG4105E1F short-chain dehydrogenase reductase FLQ07_01820 ENOG4105HUF DNA protection during starvation protein FLQ07_01830 ENOG4105C0H protease FLQ07_01840 ENOG4105F3H Histidine kinase FLQ07_01845 ENOG41067SE Tetr family transcriptional regulator FLQ07_01850 ENOG4105C9Q fumarate hydratase class II FLQ07_01880 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ07_01885 ENOG4105ENE Histidine kinase FLQ07_01900 ENOG41087YS Phage shock protein A FLQ07_01915 ENOG4108WBT adenosyltransferase FLQ07_01920 ENOG4105CHR reductase FLQ07_01940 ENOG4105C0A alcohol dehydrogenase FLQ07_01945 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FLQ07_01950 ENOG4105E0A ABC, transporter FLQ07_01955 ENOG4105EHG Permease protein FLQ07_01960 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FLQ07_01965 ENOG4105DRR Transcriptional regulator, GntR family FLQ07_01970 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FLQ07_01975 ENOG4108RPX mosc domain containing protein FLQ07_01980 ENOG4107RSM transcriptional regulator FLQ07_01990 ENOG4105CTX dehydratase FLQ07_01995 ENOG4107QZW Altronate oxidoreductase FLQ07_02000 ENOG4107KJX Transcriptional regulator FLQ07_02005 ENOG4105CT4 transporter FLQ07_02010 ENOG4105D2H Uronic isomerase FLQ07_02020 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ07_02025 ENOG4105E0A ABC, transporter FLQ07_02030 ENOG4105EHG Permease protein FLQ07_02035 ENOG4105DQ5 transport system permease protein FLQ07_02040 ENOG4105D5Q Arginine ornithine antiporter FLQ07_02050 ENOG4107K5X Membrane-bound metal-dependent hydrolase FLQ07_02055 ENOG4107QZ2 Sulfatase FLQ07_02070 ENOG4105EVU fructokinase FLQ07_02075 ENOG4107EPV Aminotransferase class V FLQ07_02085 ENOG4108WC5 Alpha Beta Hydrolase Fold protein FLQ07_02090 ENOG4105EEM helicase FLQ07_02095 ENOG4105EN6 Membrane FLQ07_02100 ENOG4105RHY Pfam:UPF0157 FLQ07_02105 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FLQ07_02115 ENOG4107ZQN disulfide bond FLQ07_02120 ENOG4105C59 p-type ATPase FLQ07_02125 ENOG4108JE9 extracellular solute-binding protein family 1 FLQ07_02130 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FLQ07_02135 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FLQ07_02140 ENOG4105CJQ hydrolase, family 31 FLQ07_02150 ENOG4105DIK (ABC) transporter FLQ07_02155 ENOG4105CC5 ABC transporter FLQ07_02160 ENOG4105DSE periplasmic solute binding protein FLQ07_02170 ENOG4105HX0 Transcriptional regulator FLQ07_02180 ENOG4105DM4 PTS System FLQ07_02185 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FLQ07_02195 ENOG4105C59 p-type ATPase FLQ07_02200 ENOG410681U heavy metal transport detoxification protein FLQ07_02205 ENOG4105VPX protein, conserved in bacteria FLQ07_02210 ENOG4107RKG DJ-1/PfpI family FLQ07_02215 ENOG4105E98 transcriptional regulator DeoR family FLQ07_02220 ENOG4105DET Rhamnulokinase FLQ07_02225 ENOG4105C9F isomerase FLQ07_02240 ENOG4105F27 Major Facilitator FLQ07_02250 ENOG410625E FLQ07_02255 ENOG4106A3M Cytochrome p-450 FLQ07_02275 ENOG4105D9R oxidoreductase FLQ07_02285 ENOG4105C72 UPF0176 protein FLQ07_02295 ENOG4106DF4 Sigma-70, region 4 FLQ07_02305 ENOG4105F0F Oxalate decarboxylase FLQ07_02325 ENOG4108MYR Secreted protein FLQ07_02330 ENOG4107SYN Glycosyl hydrolases family 43 FLQ07_02370 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FLQ07_02375 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FLQ07_02385 ENOG4105XZU Preprotein translocase, subunit SecG FLQ07_02410 ENOG4105R40 Glycine betaine carnitine choline FLQ07_02415 ENOG4108HQR Glycine betaine FLQ07_02420 ENOG4105E90 ABC transporter FLQ07_02425 ENOG4108IJ8 ABC transporter FLQ07_02430 ENOG4107HG4 Transcriptional regulator FLQ07_02435 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FLQ07_02445 ENOG4105T65 Membrane-associated protein FLQ07_02450 ENOG4108MES Periplasmic binding protein FLQ07_02470 ENOG4108V4B ThiJ pfpI FLQ07_02475 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FLQ07_02480 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FLQ07_02485 ENOG4105CP7 Triose-phosphate isomerase FLQ07_02490 ENOG4105BZA Phosphoglycerate kinase FLQ07_02500 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLQ07_02515 ENOG4105DEN Luciferase family FLQ07_02530 ENOG4105CIG ABC transporter FLQ07_02550 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FLQ07_02555 ENOG4105JXH GntR family transcriptional regulator FLQ07_02560 ENOG4105DAA L-lactate FLQ07_02565 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ07_02575 ENOG4108ZPC Polysaccharide pyruvyl transferase FLQ07_02580 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FLQ07_02585 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FLQ07_02590 ENOG4105D3Q Sugar transferase FLQ07_02600 ENOG4105K64 Glycosyl transferase, family 2 FLQ07_02610 ENOG4107QRS glycosyltransferase group 2 family protein FLQ07_02615 ENOG41068W6 Capsular polysaccharide biosynthesis protein FLQ07_02620 ENOG4108KMV Glycosyl transferase (Group 1 FLQ07_02625 ENOG4105K64 Glycosyl transferase, family 2 FLQ07_02630 ENOG4108PQP glycosyl transferase group 1 FLQ07_02640 ENOG4108QV3 biosynthesis protein FLQ07_02645 ENOG4105HTX biosynthesis protein FLQ07_02655 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FLQ07_02660 ENOG4108I5G Major Facilitator superfamily FLQ07_02670 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FLQ07_02675 ENOG4107S2N Type III effector Hrp-dependent FLQ07_02680 ENOG4105C0A alcohol dehydrogenase FLQ07_02685 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FLQ07_02690 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FLQ07_02700 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLQ07_02705 ENOG4105EDQ levansucrase EC 2.4.1.10 FLQ07_02710 ENOG4108HKT sucrose-6-phosphate hydrolase FLQ07_02725 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FLQ07_02730 ENOG4108URH decarboxylase FLQ07_02735 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FLQ07_02740 ENOG4107TVP HD domain protein FLQ07_02745 ENOG4105CHH sulfate transporter FLQ07_02750 ENOG4108V2W Carbonate dehydratase FLQ07_02755 ENOG4105C5I Dehydrogenase FLQ07_02760 ENOG4108SQ9 flavin reductase domain protein, FMN-binding FLQ07_02765 ENOG4108ZHR arsR family transcriptional regulator FLQ07_02770 ENOG4105GGE ribonuclease FLQ07_02780 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FLQ07_02785 ENOG4105KRI phosphocarrier protein (HPr FLQ07_02790 ENOG4105CIE May be required for sporulation (By similarity) FLQ07_02795 ENOG4105CHW UPF0052 protein FLQ07_02800 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FLQ07_02805 ENOG4108Z4K mutator MutT protein FLQ07_02815 ENOG4105C3M thioredoxin reductase FLQ07_02830 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FLQ07_02835 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FLQ07_02840 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FLQ07_02845 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FLQ07_02850 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FLQ07_02855 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FLQ07_02860 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FLQ07_02865 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FLQ07_02875 ENOG4108E16 pectate lyase FLQ07_02880 ENOG4108S4C acetyltransferase FLQ07_02885 ENOG4107XGZ Hydrolase FLQ07_02890 ENOG4105HKU nucleoside recognition domain-containing protein FLQ07_02900 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FLQ07_02905 ENOG410834F Transcriptional regulator FLQ07_02910 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ07_02915 ENOG41088CQ domain protein FLQ07_02920 ENOG41086DT Membrane protein of unknown function FLQ07_02925 ENOG41067S9 phage shock protein C, PspC FLQ07_02930 ENOG4108PY7 FLQ07_02945 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ07_02950 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FLQ07_02955 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FLQ07_02980 ENOG4105CN1 protease FLQ07_02985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FLQ07_02990 ENOG4105Z8B NlpC/P60 family FLQ07_02995 ENOG4105CRP Part of the ABC transporter FtsEX involved in FLQ07_03000 ENOG4105CAK Cell division ATP-binding protein ftsE FLQ07_03025 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving FLQ07_03030 ENOG4105MS2 ribosomal subunit Interface protein FLQ07_03045 ENOG4105MQ3 flagellar protein FliS FLQ07_03050 ENOG4107RT6 flagellar hook-associated FLQ07_03055 ENOG41083S7 flagellar protein FlaG FLQ07_03065 ENOG4105I03 Flagellin FLQ07_03070 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FLQ07_03075 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FLQ07_03080 ENOG4105MKD FLQ07_03085 ENOG4105DTJ flagellar hook-associated protein FLQ07_03090 ENOG4105E1Q flagellar hook-associated protein FLQ07_03105 ENOG4105RU3 FLQ07_03110 ENOG41081UC Inherit from COG: Competence protein FLQ07_03130 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ07_03135 ENOG4105BZU Histidine kinase FLQ07_03140 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FLQ07_03145 ENOG4108KGH TRANSCRIPTIONal FLQ07_03155 ENOG4105ESV Glycosyl transferase, family 4 FLQ07_03160 ENOG4107EF8 Glycosyl transferase (Group 1 FLQ07_03175 ENOG4105QZI O-Antigen Polymerase FLQ07_03180 ENOG4105C1B dTDP-glucose 4-6-dehydratase FLQ07_03185 ENOG4105C6Y Udp-glucose 6-dehydrogenase FLQ07_03190 ENOG4107RA4 Glycosyl transferase (Group 1 FLQ07_03195 ENOG4105PSV Polysaccharide Biosynthesis Protein FLQ07_03200 ENOG4105D3Q Sugar transferase FLQ07_03205 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ07_03210 ENOG4105JFG SpoIID LytB domain protein FLQ07_03220 ENOG4108KGH TRANSCRIPTIONal FLQ07_03225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FLQ07_03230 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FLQ07_03245 ENOG4107VDP teichoic acid biosynthesis FLQ07_03250 ENOG41088M2 Glycosyl transferase family 2 FLQ07_03265 ENOG4105EY8 ABC transporter FLQ07_03280 ENOG4107SJB teichoic acid biosynthesis FLQ07_03285 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FLQ07_03295 ENOG4107RZX Teichoic acid biosynthesis protein FLQ07_03305 ENOG4105DG6 mannose-6-phosphate isomerase FLQ07_03315 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FLQ07_03320 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) FLQ07_03325 ENOG4108UHU Aldolase FLQ07_03330 ENOG4105D7K pfkb domain protein FLQ07_03335 ENOG4108M60 Transcriptional regulator FLQ07_03345 ENOG4105CHR reductase FLQ07_03350 ENOG4105E2A Dehydrogenase FLQ07_03355 ENOG4105C54 Major Facilitator superfamily FLQ07_03360 ENOG4108KGH TRANSCRIPTIONal FLQ07_03365 ENOG4105J7I hydrolase FLQ07_03370 ENOG4105K4H Nlp p60 protein FLQ07_03375 ENOG4105PNM synthesis protein FLQ07_03385 ENOG4105N98 Capsule biosynthesis protein capB FLQ07_03390 ENOG4105ETE Transcriptional regulator (LacI family FLQ07_03395 ENOG4108RVA ribokinase FLQ07_03400 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FLQ07_03405 ENOG4105C2J ABC transporter FLQ07_03410 ENOG4105CNN ABC, transporter FLQ07_03415 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FLQ07_03420 ENOG4105C5Q Transcriptional regulator FLQ07_03425 ENOG41089UC methyltransferase, type 11 FLQ07_03430 ENOG4107FQX Alpha-acetolactate decarboxylase FLQ07_03440 ENOG4107RSM transcriptional regulator FLQ07_03445 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FLQ07_03455 ENOG4105CAH Chromate FLQ07_03460 ENOG4105FGV Chromate FLQ07_03465 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FLQ07_03470 ENOG4105HTX biosynthesis protein FLQ07_03480 ENOG4105KBK Zinc finger, swim domain protein FLQ07_03485 ENOG4105C0D helicase FLQ07_03490 ENOG4108XI2 Domain of unknown function (DUF1963) FLQ07_03495 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FLQ07_03510 ENOG410667J hydrolase FLQ07_03515 ENOG4105E98 transcriptional regulator DeoR family FLQ07_03520 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FLQ07_03525 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FLQ07_03530 ENOG4105VI0 Pts system, glucitol sorbitol-specific FLQ07_03535 ENOG4105DZY Pts system, glucitol sorbitol-specific FLQ07_03540 ENOG410787A Pts system, glucitol sorbitol-specific FLQ07_03550 ENOG4105DKT Transcriptional regulator FLQ07_03555 ENOG4105Z8H single-stranded DNA-binding protein FLQ07_03575 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FLQ07_03580 ENOG4105CGA flagellar basal-body rod protein FlgG FLQ07_03590 ENOG4105DFF Rod shape-determining protein mreb FLQ07_03595 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FLQ07_03605 ENOG4107MII Sugar-specific transcriptional regulator TrmB FLQ07_03610 ENOG4105CZM Major Facilitator FLQ07_03615 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FLQ07_03620 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FLQ07_03630 ENOG4108NA0 Uncharacterized conserved protein (COG2071) FLQ07_03645 ENOG41080XP Cbs domain FLQ07_03655 ENOG4105C37 (CBS) domain FLQ07_03660 ENOG4105BZU Histidine kinase FLQ07_03680 ENOG4105FRN stage II sporulation protein FLQ07_03685 ENOG4107TCE N-acetyltransferase FLQ07_03695 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FLQ07_03700 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ07_03705 ENOG4105WQT MbtH domain protein FLQ07_03710 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_03715 ENOG4105WQI isochorismatase FLQ07_03720 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FLQ07_03725 ENOG4105E4F Isochorismate synthase FLQ07_03730 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FLQ07_03735 ENOG4105NIV Esterase FLQ07_03755 ENOG410874W AraC family transcriptional regulator FLQ07_03765 ENOG4108RYK Nad-dependent epimerase dehydratase FLQ07_03770 ENOG4108Z40 Transcriptional regulator FLQ07_03785 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FLQ07_03790 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FLQ07_03795 ENOG4105FCD Major Facilitator FLQ07_03800 ENOG4108HIZ formate dehydrogenase alpha subunit FLQ07_03805 ENOG4108TF4 von Willebrand factor, type A FLQ07_03820 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FLQ07_03830 ENOG4106778 Protein of unknown function (DUF1146) FLQ07_03835 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FLQ07_03840 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FLQ07_03845 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FLQ07_03850 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FLQ07_03855 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FLQ07_03870 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FLQ07_03885 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FLQ07_03890 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FLQ07_03895 ENOG4108UIC UPF0340 protein FLQ07_03900 ENOG4108YZG isomerase FLQ07_03905 ENOG4107WAU Protein tyrosine phosphatase FLQ07_03910 ENOG410815N Probably functions as a manganese efflux pump (By similarity) FLQ07_03915 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FLQ07_03925 ENOG4108ZXQ stage ii sporulation protein r FLQ07_03940 ENOG4105TRI Hydrolase FLQ07_03965 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FLQ07_03970 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FLQ07_03975 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FLQ07_03985 ENOG4107TT2 Auxin Efflux Carrier FLQ07_03990 ENOG4105C6K Malic enzyme FLQ07_03995 ENOG4107104 thymidine kinase FLQ07_04000 ENOG41082DI 50s ribosomal protein l31 FLQ07_04005 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FLQ07_04010 ENOG4105CBT Fructose-1,6-bisphosphatase FLQ07_04015 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FLQ07_04020 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway FLQ07_04025 ENOG4105D2N Aldolase FLQ07_04030 ENOG410812K response regulator receiver protein FLQ07_04040 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FLQ07_04050 ENOG4105C1G acyl-Coa dehydrogenase FLQ07_04055 ENOG4105C1G acyl-Coa dehydrogenase FLQ07_04060 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FLQ07_04070 ENOG4105DF6 Fe-S oxidoreductase FLQ07_04085 ENOG4105C75 arginyL-tRNA synthetase FLQ07_04090 ENOG410684U Domain of unknown function (DUF1934) FLQ07_04095 ENOG4105CYW agmatinase FLQ07_04100 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FLQ07_04105 ENOG4105BZ4 penicillin-binding protein FLQ07_04110 ENOG4108XFG YwhD family FLQ07_04115 ENOG4108Z4T Peptidase M50 FLQ07_04120 ENOG41069HH 4-oxalocrotonate tautomerase FLQ07_04135 ENOG4105DCI Phosphohydrolase FLQ07_04145 ENOG4108VCI transcription factor, rsfa family FLQ07_04155 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FLQ07_04165 ENOG4105D2S major facilitator superfamily FLQ07_04190 ENOG4107258 Transcriptional regulator FLQ07_04200 ENOG4108IJ2 phosphate acetyltransferase FLQ07_04205 ENOG4107JTW chlorite dismutase FLQ07_04220 ENOG4105CZN Potassium uptake protein FLQ07_04240 ENOG4105CJ1 ABC, transporter FLQ07_04270 ENOG4105C26 Dehydrogenase FLQ07_04275 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FLQ07_04280 ENOG4108RJ9 Glycosyl transferase, family 2 FLQ07_04285 ENOG4105DWF phosphomethylpyrimidine kinase FLQ07_04300 ENOG4105C5Y PTS System FLQ07_04315 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ07_04325 ENOG4105DEN Luciferase family FLQ07_04330 ENOG4108DBC nitroreductase FLQ07_04350 ENOG4105DWD nucleoside recognition domain protein FLQ07_04405 ENOG41060D1 Quinol oxidase FLQ07_04415 ENOG4105BZ9 Cytochrome C oxidase, subunit I FLQ07_04420 ENOG4105E2S oxidase) subunit II FLQ07_04425 ENOG4105CMR udp-glucose 4-epimerase FLQ07_04440 ENOG4108WS4 fmn reductase FLQ07_04455 ENOG4105CMG Carbohydrate kinase FLQ07_04460 ENOG4105C93 Xylose Isomerase FLQ07_04465 ENOG4105E2R ROK family FLQ07_04470 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FLQ07_04475 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FLQ07_04480 ENOG4105CMU LysR family (Transcriptional regulator FLQ07_04500 ENOG41067MG lrgb family FLQ07_04510 ENOG4105CK7 Sodium proline symporter FLQ07_04515 ENOG4105DR4 Methyltransferase FLQ07_04525 ENOG4105C5I Dehydrogenase FLQ07_04530 ENOG4105X1N Glycosyl transferase family 8 FLQ07_04540 ENOG4105ENE Histidine kinase FLQ07_04545 ENOG4108VB1 regulatoR FLQ07_04550 ENOG4105EYF MMPL domain protein FLQ07_04560 ENOG4105DJB Major Facilitator Superfamily FLQ07_04565 ENOG4105CXK mandelate racemase muconate lactonizing FLQ07_04570 ENOG4108UHU Aldolase FLQ07_04575 ENOG4105D7K pfkb domain protein FLQ07_04585 ENOG4105IIU Aminopeptidase FLQ07_04590 ENOG41080V3 Major Facilitator superfamily FLQ07_04620 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FLQ07_04625 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FLQ07_04630 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) FLQ07_04635 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FLQ07_04640 ENOG4105CM2 brancheD-chain amino acid aminotransferase FLQ07_04650 ENOG4105F8D glycoside hydrolase family 4 FLQ07_04655 ENOG4105VCP PTS System FLQ07_04660 ENOG4105CK1 PTS System FLQ07_04665 ENOG4105VZJ PTS System FLQ07_04670 ENOG4105EMD TRANSCRIPTIONal FLQ07_04675 ENOG4108VX5 3-methyladenine DNA glycosylase FLQ07_04690 ENOG4105DXD 2-methylcitrate dehydratase FLQ07_04695 ENOG4105CR4 methylisocitrate lyase FLQ07_04710 ENOG4105BZ1 (ABC) transporter FLQ07_04715 ENOG4107TDE lipolytic protein G-D-S-L family FLQ07_04730 ENOG4105C2C drug resistance transporter, Bcr CflA FLQ07_04740 ENOG4105DA5 (ABC) transporter FLQ07_04745 ENOG41069JR FLQ07_04775 ENOG4105CH6 catalase FLQ07_04785 ENOG4105G5W regulator Fur family FLQ07_04790 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FLQ07_04795 ENOG4108J20 pectate lyase FLQ07_04800 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FLQ07_04805 ENOG4108JJ8 (ABC) transporter FLQ07_04810 ENOG4108JJ9 ABC, transporter FLQ07_04815 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FLQ07_04820 ENOG4105C4M (Ubiquinol oxidase) subunit I FLQ07_04830 ENOG4108QTI )-transporter FLQ07_04845 ENOG4105DFD Na H antiporter FLQ07_04850 ENOG4108IJ0 Aspartate ammonia-lyase FLQ07_04855 ENOG4105HDK L-asparaginase FLQ07_04860 ENOG4108IMY Transcriptional regulator FLQ07_04865 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FLQ07_04905 ENOG4107BJW polysaccharide deacetylase FLQ07_04910 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ07_04920 ENOG4107QZ7 Cellulose synthase catalytic subunit FLQ07_04925 ENOG4105D2K citrate carrier protein FLQ07_04935 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FLQ07_04940 ENOG4105X3H Excalibur domain protein FLQ07_04950 ENOG4105E0M Sulfatase FLQ07_04960 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FLQ07_04980 ENOG4105CEU Arginine dihydrolase FLQ07_04985 ENOG4105DBV ornithine carbamoyltransferase FLQ07_04995 ENOG4105C5B carbamate kinase FLQ07_05005 ENOG4105CS2 ec 3.2.1.21 FLQ07_05010 ENOG4105CK1 PTS System FLQ07_05020 ENOG4105JVQ RNA Polymerase FLQ07_05030 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FLQ07_05040 ENOG4108HKT sucrose-6-phosphate hydrolase FLQ07_05045 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FLQ07_05050 ENOG4105DRS transport system, permease FLQ07_05055 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FLQ07_05065 ENOG4105ETE Transcriptional regulator (LacI family FLQ07_05085 ENOG4105EDW glycosyl transferase, family 39 FLQ07_05090 ENOG4105CKK Glycosyl transferase, family 2 FLQ07_05095 ENOG4105CMR udp-glucose 4-epimerase FLQ07_05125 ENOG4105CH6 catalase FLQ07_05135 ENOG4105CS2 ec 3.2.1.21 FLQ07_05140 ENOG4105C5Y PTS System FLQ07_05145 ENOG4105CID antiterminator FLQ07_05150 ENOG4108W7F transporter, permease FLQ07_05155 ENOG4108JJB ABC transporter FLQ07_05160 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein FLQ07_05165 ENOG4105ETU transcriptional activator (TenA FLQ07_05175 ENOG4107QP3 malate synthase g FLQ07_05185 ENOG4105EDW glycosyl transferase, family 39 FLQ07_05235 ENOG4105C19 ABC transporter FLQ07_05240 ENOG4105EWM Histidine kinase FLQ07_05250 ENOG4105CS2 ec 3.2.1.21 FLQ07_05255 ENOG4105C5Y PTS System FLQ07_05265 ENOG4107QHE Choloylglycine hydrolase FLQ07_05270 ENOG4106Z5D Glycoside Hydrolase Family 43 FLQ07_05275 ENOG4105C1J atp-dependent rna helicase FLQ07_05290 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FLQ07_05295 ENOG4105D9N nucleoside FLQ07_05300 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FLQ07_05305 ENOG4107RHR regulatoR FLQ07_05315 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FLQ07_05320 ENOG4107R8N Glycosyl transferase, family 2 FLQ07_05330 ENOG4105JKW Valine--pyruvate aminotransferase FLQ07_05355 ENOG4105D2N Aldolase FLQ07_05360 ENOG4107TRN Xylose isomerase domain protein TIM barrel FLQ07_05365 ENOG4105F0H myo-inositol catabolism protein FLQ07_05370 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FLQ07_05380 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FLQ07_05385 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FLQ07_05390 ENOG4105D7K pfkb domain protein FLQ07_05395 ENOG4105DH8 myo-inositol catabolism FLQ07_05400 ENOG4105C26 Dehydrogenase FLQ07_05410 ENOG4105CPC Aldo Keto reductase FLQ07_05415 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FLQ07_05420 ENOG4105CXY transporter FLQ07_05425 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FLQ07_05430 ENOG4105C5H ABC transporter FLQ07_05435 ENOG410667J hydrolase FLQ07_05445 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FLQ07_05455 ENOG4108V5C ABC transporter FLQ07_05485 ENOG4105H93 Acyltransferase family FLQ07_05515 ENOG4105EC8 Methyl-accepting chemotaxis FLQ07_05520 ENOG4105BZG amino acid carrier protein FLQ07_05525 ENOG4105DCF alanine dehydrogenase FLQ07_05540 ENOG4105EG2 ABC transporter, permease FLQ07_05550 ENOG4107FKK extracellular solute-binding protein family 1 FLQ07_05560 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FLQ07_05565 ENOG4105CMR udp-glucose 4-epimerase FLQ07_05570 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FLQ07_05575 ENOG4105E2R ROK family FLQ07_05585 ENOG41082J7 Rhodanese domain protein FLQ07_05600 ENOG4105CMG Carbohydrate kinase FLQ07_05620 ENOG4108EKI Dehydrogenase FLQ07_05625 ENOG4105D3R alkyl hydroperoxide reductase FLQ07_05630 ENOG4108JU3 Alkyl hydroperoxide reductase FLQ07_05635 ENOG4105C85 amino acid FLQ07_05640 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 FLQ07_05650 ENOG41065SU Two-component system sensor kinase FLQ07_05675 ENOG4105DQ5 transport system permease protein FLQ07_05680 ENOG4105EHG Permease protein FLQ07_05695 ENOG4108M15 ABC transporter FLQ07_05700 ENOG4105KCT ABC transporter FLQ07_05705 ENOG4105BZU Histidine kinase FLQ07_05715 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ07_05725 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FLQ07_05740 ENOG4105WQG acetyltransferase FLQ07_05755 ENOG4105C0H protease FLQ07_05760 ENOG4105Q2H domain protein FLQ07_05775 ENOG4105BZU Histidine kinase FLQ07_05780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ07_05810 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FLQ07_05820 ENOG4105CDU Replicative dna helicase FLQ07_05840 ENOG4105DJ2 Major Facilitator Superfamily FLQ07_05845 ENOG4105CE4 GlcNAc 6-P deacetylase FLQ07_05850 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FLQ07_05855 ENOG4105FDP GntR family transcriptional regulator FLQ07_05860 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FLQ07_05870 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FLQ07_05875 ENOG4105BZR domain protein FLQ07_05880 ENOG4108XMW Membrane FLQ07_05890 ENOG4107YZX Universal stress protein FLQ07_05895 ENOG4105CHH sulfate transporter FLQ07_05905 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FLQ07_05910 ENOG4108UUM single-stranded DNA-binding protein FLQ07_05915 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FLQ07_05920 ENOG4105C3G gtp-binding protein FLQ07_05930 ENOG4105VDK protein, conserved in bacteria FLQ07_05940 ENOG4108ZDA Sporulation protein YyaC FLQ07_05945 ENOG4105FA0 parb-like partition protein FLQ07_05950 ENOG4107QJE Chromosome Partitioning Protein FLQ07_05955 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FLQ07_05960 ENOG4108KPJ rna polymerase sigma factor FLQ07_05965 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) FLQ07_05975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FLQ07_05980 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FLQ07_05995 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FLQ07_06005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FLQ07_06010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FLQ07_06015 ENOG410848D S4 domain protein YaaA FLQ07_06020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FLQ07_06030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLQ07_06035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLQ07_06070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FLQ07_06080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FLQ07_06085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FLQ07_06090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FLQ07_06095 ENOG4105BZW Glycerate kinase FLQ07_06100 ENOG4107QQ0 gntp family FLQ07_06105 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FLQ07_06120 ENOG4105ZMH deoxynucleoside kinase FLQ07_06130 ENOG4105VRS hydrolase family 18 FLQ07_06135 ENOG4105GTG Isochorismatase FLQ07_06140 ENOG4108Z6B deaminase FLQ07_06150 ENOG4105C6E dna polymerase iii FLQ07_06155 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FLQ07_06160 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FLQ07_06170 ENOG41067KS pro-sigma K processing FLQ07_06210 ENOG4105CDW Resistance protein FLQ07_06215 ENOG4105CXN decarboxylase FLQ07_06220 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FLQ07_06225 ENOG4105X0R protein from nitrogen regulatory protein P-II FLQ07_06230 ENOG4105XVJ Protein of unknown function (DUF327) FLQ07_06235 ENOG4105FA2 dna polymerase iii FLQ07_06240 ENOG4105MA4 psp1 domain protein FLQ07_06245 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) FLQ07_06250 ENOG41060K3 Methyltransferase FLQ07_06255 ENOG4105VC4 domain protein FLQ07_06260 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FLQ07_06265 ENOG4105KRN Transcriptional regulator, abrb family FLQ07_06270 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FLQ07_06275 ENOG4105F8V Hydrolase, tatD family FLQ07_06280 ENOG41069ER domain protein FLQ07_06290 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FLQ07_06295 ENOG4105XFA sporulation peptidase YabG FLQ07_06300 ENOG4105W42 Veg protein FLQ07_06305 ENOG4105XEW small acid-soluble spore protein FLQ07_06310 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FLQ07_06315 ENOG4105DFT pur operon repressor FLQ07_06320 ENOG4105KME endoribonuclease L-psp FLQ07_06325 ENOG4105K4W Could be involved in septation (By similarity) FLQ07_06330 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FLQ07_06335 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FLQ07_06340 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FLQ07_06355 ENOG4108JA2 transcriptioN-repair coupling factor FLQ07_06360 ENOG4108M14 stage v sporulation protein t FLQ07_06370 ENOG4108IY2 MazG family FLQ07_06375 ENOG41082I2 s4 domain protein FLQ07_06380 ENOG4105VYY sporulation protein yabp FLQ07_06395 ENOG41060GV RNA binding s1 domain protein FLQ07_06425 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FLQ07_06430 ENOG4108UGV hypoxanthine phosphoribosyltransferase FLQ07_06435 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FLQ07_06440 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FLQ07_06445 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FLQ07_06450 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase FLQ07_06455 ENOG4105C6T cysteine synthase FLQ07_06465 ENOG4105CRQ synthase (Component I) FLQ07_06470 ENOG4105DDQ anthranilate synthase FLQ07_06475 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FLQ07_06480 ENOG4105EEI dihydropteroate synthase FLQ07_06485 ENOG4105KRF dihydroneopterin aldolase FLQ07_06490 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FLQ07_06500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FLQ07_06505 ENOG4105CRK lysyL-tRNA synthetase FLQ07_06590 ENOG4108Z0C Uvrb UvrC protein FLQ07_06595 ENOG41066A3 ATP guanido phosphotransferase FLQ07_06605 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FLQ07_06610 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FLQ07_06615 ENOG4105CTP PilT protein domain protein FLQ07_06620 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FLQ07_06625 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FLQ07_06630 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FLQ07_06635 ENOG4105D7W serine acetyltransferase FLQ07_06640 ENOG4105C8N cysteinyl-tRNA synthetase FLQ07_06645 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FLQ07_06650 ENOG4105C2N RNA methyltransferase TrmH family group 3 FLQ07_06655 ENOG4105M0M Tetracycline resistance protein FLQ07_06660 ENOG4105QIV RNA polymerase FLQ07_06670 ENOG410683Z Preprotein translocase SecE subunit FLQ07_06675 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FLQ07_06680 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FLQ07_06685 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FLQ07_06690 ENOG4108VZM 50s ribosomal protein L10 FLQ07_06695 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FLQ07_06700 ENOG4107Y49 methyltransferase FLQ07_06705 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ07_06710 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ07_06715 ENOG4105XPM ribosomal protein FLQ07_06720 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FLQ07_06725 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FLQ07_06730 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FLQ07_06735 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) FLQ07_06740 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FLQ07_06745 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FLQ07_06750 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FLQ07_06755 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FLQ07_06760 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FLQ07_06765 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FLQ07_06770 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FLQ07_06775 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FLQ07_06780 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FLQ07_06785 ENOG41082SA 50s ribosomal protein l29 FLQ07_06790 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FLQ07_06795 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FLQ07_06800 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FLQ07_06805 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FLQ07_06810 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FLQ07_06815 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FLQ07_06820 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FLQ07_06825 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FLQ07_06830 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FLQ07_06835 ENOG4105VPB 50S ribosomal protein L30 FLQ07_06840 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FLQ07_06845 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FLQ07_06850 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FLQ07_06855 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FLQ07_06865 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FLQ07_06875 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FLQ07_06880 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FLQ07_06885 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FLQ07_06890 ENOG4108ZT0 50S ribosomal protein l17 FLQ07_06895 ENOG4108JJB ABC transporter FLQ07_06900 ENOG4108JJB ABC transporter FLQ07_06905 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FLQ07_06910 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FLQ07_06915 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FLQ07_06920 ENOG4108UJD 30S ribosomal protein S9 FLQ07_07000 ENOG4108JJA ABC, transporter FLQ07_07025 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FLQ07_07055 ENOG4105D1F ATP-binding protein FLQ07_07070 ENOG4108NMV polysaccharide deacetylase FLQ07_07100 ENOG4108A04 Beta-lactamase FLQ07_07120 ENOG4105JAB phenazine biosynthesis protein, phzf family FLQ07_07125 ENOG4105EHZ conserved protein UCP016719 FLQ07_07130 ENOG4105D17 glycoside hydrolase, family 3 domain protein FLQ07_07150 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FLQ07_07155 ENOG4105EWC Purine nucleoside phosphorylase FLQ07_07190 ENOG4105EMN RNA polymerase sigma factor FLQ07_07200 ENOG4105C8B TIGR00159 family FLQ07_07205 ENOG4107U5W ybbr family FLQ07_07210 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FLQ07_07215 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FLQ07_07235 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FLQ07_07245 ENOG4107SWG transcriptional regulator MERR family FLQ07_07255 ENOG4105WAB arsR family transcriptional regulator FLQ07_07260 ENOG4108RWP Major Facilitator Superfamily protein FLQ07_07280 ENOG4105DA5 (ABC) transporter FLQ07_07305 ENOG4105BZ1 (ABC) transporter FLQ07_07310 ENOG4107ZXU DSBA oxidoreductase FLQ07_07320 ENOG4105BZ1 (ABC) transporter FLQ07_07330 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FLQ07_07360 ENOG4108MRH transcriptional regulatory protein FLQ07_07380 ENOG4106DDH Sporulation-specific SASP protein FLQ07_07395 ENOG4105C7Z Conserved Protein FLQ07_07400 ENOG4105FTQ Dna gyrase FLQ07_07415 ENOG4105ED2 Beta-lactamase FLQ07_07420 ENOG4105C7Z Conserved Protein FLQ07_07425 ENOG4105FTQ Dna gyrase FLQ07_07430 ENOG4105C7Z Conserved Protein FLQ07_07450 ENOG4105KRN Transcriptional regulator, abrb family FLQ07_07470 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FLQ07_07475 ENOG4105DY8 decarboxylase FLQ07_07480 ENOG4108TVJ Nitroreductase FLQ07_07485 ENOG4105DRR Transcriptional regulator, GntR family FLQ07_07515 ENOG4107I77 yiaA/B two helix domain FLQ07_07540 ENOG410631K Membrane FLQ07_07545 ENOG4106AXJ AraC family transcriptional regulator FLQ07_07555 ENOG4107WYG Transcriptional regulator, luxr family FLQ07_07570 ENOG4107SCQ Iron-containing alcohol dehydrogenase FLQ07_07585 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid FLQ07_07595 ENOG4108IQI permease FLQ07_07600 ENOG4108J5H Homocysteine s-methyltransferase FLQ07_07615 ENOG4107TXC Transcriptional regulator FLQ07_07620 ENOG4108QY0 Membrane FLQ07_07640 ENOG4105CSV Glutaminase FLQ07_07655 ENOG4105KNA -acetyltransferase FLQ07_07665 ENOG4105NA0 Transcriptional regulator FLQ07_07675 ENOG4105DGI Alkaline phosphatase FLQ07_07680 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FLQ07_07685 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FLQ07_07690 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase FLQ07_07695 ENOG4105C26 Dehydrogenase FLQ07_07700 ENOG4105DJB Major Facilitator Superfamily FLQ07_07705 ENOG4105EQX glucarate dehydratase FLQ07_07710 ENOG41073TP transcriptional regulator FLQ07_07715 ENOG4105CTX dehydratase FLQ07_07725 ENOG4106FGC FLQ07_07735 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ07_07760 ENOG4108R1P FLQ07_07765 ENOG4106K80 FLQ07_07775 ENOG41067TZ transcriptional regulator, MarR family FLQ07_07800 ENOG4107TXC Transcriptional regulator FLQ07_07820 ENOG4106UX7 integral membrane protein FLQ07_07830 ENOG41060AI SEC-C motif FLQ07_07835 ENOG4105DA5 (ABC) transporter FLQ07_07860 ENOG4108KSA LysR family transcriptional regulator FLQ07_07865 ENOG4105MDS 4-oxalocrotonate tautomerase FLQ07_07895 ENOG4107RB3 L-asparaginase FLQ07_07900 ENOG4108W0I acetyltransferase FLQ07_07915 ENOG4107BMA Transglycosylase associated protein FLQ07_07925 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FLQ07_07930 ENOG4105CQB FAD linked oxidase domain protein FLQ07_07935 ENOG4105VZJ PTS System FLQ07_07940 ENOG4105VCP PTS System FLQ07_07945 ENOG4105CK1 PTS System FLQ07_07950 ENOG4105F8D glycoside hydrolase family 4 FLQ07_07955 ENOG4108X79 transcriptional regulator FLQ07_07960 ENOG410901P UPF0249 protein FLQ07_07975 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases FLQ07_07980 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FLQ07_08005 ENOG4105DEN Luciferase family FLQ07_08010 ENOG4105Z8B NlpC/P60 family FLQ07_08020 ENOG4105CIG ABC transporter FLQ07_08025 ENOG4108RZE Tetr family transcriptional regulator FLQ07_08045 ENOG4108N0M stress protein FLQ07_08050 ENOG4106FN3 tellurium resistance protein FLQ07_08055 ENOG4106FN3 tellurium resistance protein FLQ07_08060 ENOG4107TS3 membrane protein, TerC FLQ07_08075 ENOG4108TTB tellurium resistance protein FLQ07_08085 ENOG4107QIV Cytochrome c biogenesis protein FLQ07_08125 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FLQ07_08130 ENOG410756H nucleotidyltransferase FLQ07_08140 ENOG4105C26 Dehydrogenase FLQ07_08145 ENOG4105CK7 Sodium proline symporter FLQ07_08150 ENOG4107YHD transcriptional regulator FLQ07_08160 ENOG4108PJD permease FLQ07_08165 ENOG4105I82 acetyl xylan esterase FLQ07_08185 ENOG4105E5Q amino acid AbC transporter FLQ07_08190 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein FLQ07_08195 ENOG4105NF4 modulator of drug activity FLQ07_08200 ENOG4105E2Y ABC, transporter FLQ07_08205 ENOG4105CS2 ec 3.2.1.21 FLQ07_08220 ENOG4105D9P serine threonine protein kinase FLQ07_08250 ENOG4105F38 ABC transporter, permease FLQ07_08255 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FLQ07_08260 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_08280 ENOG4105SX7 Transporter FLQ07_08290 ENOG4105W8Z 4'-phosphopantetheinyl transferase FLQ07_08295 ENOG4108SA1 esterase FLQ07_08300 ENOG41086D8 Transcriptional regulator FLQ07_08335 ENOG41067SE Tetr family transcriptional regulator FLQ07_08345 ENOG4105CDA abc transporter atp-binding protein FLQ07_08350 ENOG4105DRP amino acid AbC transporter FLQ07_08360 ENOG4108JUB Transcriptional regulator FLQ07_08365 ENOG4105C8Y Acetylornithine aminotransferase FLQ07_08370 ENOG4108IQI permease FLQ07_08375 ENOG41066UZ arginase EC 3.5.3.1 FLQ07_08380 ENOG4106P55 Transcriptional regulator FLQ07_08385 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FLQ07_08390 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FLQ07_08395 ENOG41069ZX FLQ07_08400 ENOG41069ZX FLQ07_08460 ENOG4105C2F Histidine kinase FLQ07_08465 ENOG4105EQD regulatoR FLQ07_08470 ENOG4105DFW ABC transporter FLQ07_08480 ENOG4108HWW ABC transporter FLQ07_08485 ENOG4105DCM major facilitator superfamily FLQ07_08490 ENOG410645S MarR family Transcriptional regulator FLQ07_08495 ENOG4105C4C beta-galactosidase FLQ07_08500 ENOG4107T32 3-phytase (EC 3.1.3.8) FLQ07_08525 ENOG4105E1K spore germination protein FLQ07_08540 ENOG4107TXC Transcriptional regulator FLQ07_08550 ENOG4107WD8 ABC transporter, permease FLQ07_08555 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ07_08560 ENOG4105BZU Histidine kinase FLQ07_08565 ENOG4105C8Q Methyl-accepting chemotaxis FLQ07_08570 ENOG4105CFH Aspartokinase FLQ07_08575 ENOG4105DHS permease protein FLQ07_08580 ENOG4105CM4 permease protein FLQ07_08585 ENOG4108IPW abc transporter atp-binding protein FLQ07_08600 ENOG4105R8C Transcriptional regulator FLQ07_08610 ENOG4108DBC nitroreductase FLQ07_08615 ENOG41067V3 Antibiotic biosynthesis monooxygenase FLQ07_08620 ENOG4105YVS arsR family transcriptional regulator FLQ07_08630 ENOG4108JPW Aminotransferase FLQ07_08635 ENOG4107QTZ amino acid FLQ07_08640 ENOG4105C26 Dehydrogenase FLQ07_08645 ENOG4108RNG Permease of the drug metabolite transporter FLQ07_08655 ENOG4105KTB nuclear export factor GLE1 FLQ07_08660 ENOG4108T5E Copper resistance protein FLQ07_08665 ENOG4108ZYE Transcriptional regulator FLQ07_08675 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FLQ07_08680 ENOG4108IFG nitrite reductase, (NAD(P)H) FLQ07_08685 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FLQ07_08690 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FLQ07_08695 ENOG4105DRR Transcriptional regulator, GntR family FLQ07_08700 ENOG4105C8P )-transporter FLQ07_08715 ENOG4106ETB IIa component FLQ07_08735 ENOG4108IUS Transketolase FLQ07_08745 ENOG4105E7W lamb ycsf family protein FLQ07_08750 ENOG4105C5A transporter FLQ07_08755 ENOG4105CFM UPF0317 protein FLQ07_08760 ENOG4105P4J Allophanate hydrolase, subunit 1 FLQ07_08770 ENOG4107258 Transcriptional regulator FLQ07_08775 ENOG4105XJB lipolytic protein G-D-S-L family FLQ07_08790 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FLQ07_08795 ENOG4105ETD TRANSCRIPTIONal FLQ07_08815 ENOG410606W general stress protein FLQ07_08825 ENOG4108RCF TRANSCRIPTIONal FLQ07_08830 ENOG4105VCH membrane FLQ07_08845 ENOG4105C9U ATP-dependent DNA helicase RecQ FLQ07_08870 ENOG4108M1A Chitin-binding protein FLQ07_08885 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FLQ07_08890 ENOG4107BMA Transglycosylase associated protein FLQ07_08895 ENOG4108IJ0 Aspartate ammonia-lyase FLQ07_08900 ENOG41087PP glycosyltransferase MGT family FLQ07_08905 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) FLQ07_08910 ENOG4105EU9 FLQ07_08920 ENOG41082W1 Cupin 2, conserved barrel domain protein FLQ07_08925 ENOG4105QVS general stress protein FLQ07_08930 ENOG4106F5Q Membrane FLQ07_08935 ENOG4105CK2 sodium dicarboxylate symporter FLQ07_08940 ENOG4105CJ1 ABC, transporter FLQ07_08955 ENOG4105FDT acyl-CoA dehydrogenase FLQ07_08970 ENOG4105SZ6 Thioredoxin FLQ07_08975 ENOG4105CPF Cell wall formation (By similarity) FLQ07_08980 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FLQ07_08990 ENOG4105C1J atp-dependent rna helicase FLQ07_08995 ENOG410905X membrane-flanked domain protein FLQ07_09000 ENOG4105CKV Membrane FLQ07_09010 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FLQ07_09015 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FLQ07_09025 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FLQ07_09030 ENOG4107MMM Anti-sigma-factor antagonist FLQ07_09035 ENOG4105FUA antagonist FLQ07_09040 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FLQ07_09045 ENOG4107SGM protein serine threonine phosphatase FLQ07_09065 ENOG41064BQ Phosphatase FLQ07_09075 ENOG4105ST3 Transcriptional regulator FLQ07_09085 ENOG4105EYF MMPL domain protein FLQ07_09145 ENOG41085FC arsR family transcriptional regulator FLQ07_09150 ENOG41082YX Transcriptional regulator, arsr family FLQ07_09160 ENOG4108UXE Protein tyrosine phosphatase FLQ07_09165 ENOG4107T94 Endo-14-beta-xylanase FLQ07_09170 ENOG4105ECK Fatty Acid Desaturase FLQ07_09175 ENOG4105VEQ Cold shock protein FLQ07_09185 ENOG4107U9B transcriptional regulator FLQ07_09190 ENOG4105DXI Major Facilitator superfamily FLQ07_09205 ENOG4108U05 Transcriptional regulator FLQ07_09210 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FLQ07_09225 ENOG4105KVH Transcriptional regulator FLQ07_09245 ENOG4105MJ9 esterase FLQ07_09250 ENOG4107Z6X Transcriptional regulator FLQ07_09265 ENOG4107XCH Cyclase family FLQ07_09285 ENOG4108VQT Alpha beta hydrolase fold protein FLQ07_09290 ENOG4105X5K response regulator receiver protein FLQ07_09295 ENOG4105JVQ RNA Polymerase FLQ07_09300 ENOG4108P49 AntiSigma factor FLQ07_09305 ENOG4105EXC Acyl-transferase FLQ07_09315 ENOG4105C2C drug resistance transporter, Bcr CflA FLQ07_09330 ENOG4108NEV two component transcriptional regulator, LytTR family FLQ07_09340 ENOG4108Z6X (sortase) family FLQ07_09345 ENOG4107QNK )-transporter FLQ07_09385 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FLQ07_09390 ENOG4105K8N protein family UPF0079, ATPase FLQ07_09395 ENOG41072GX Peptidase M22 Glycoprotease FLQ07_09400 ENOG410801F ribosomal-protein-alanine acetyltransferase FLQ07_09405 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FLQ07_09410 ENOG4105C5H ABC transporter FLQ07_09420 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FLQ07_09425 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FLQ07_09430 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FLQ07_09440 ENOG4108TYN CAAX amino terminal protease family protein FLQ07_09445 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FLQ07_09450 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FLQ07_09470 ENOG41067QW Transcriptional regulator FLQ07_09475 ENOG41067QW Transcriptional regulator FLQ07_09615 ENOG4105IG6 Phage terminase, large subunit FLQ07_09620 ENOG4108MDF Phage Portal Protein FLQ07_09625 ENOG4106CGH Phage Mu protein F like protein FLQ07_09655 ENOG41060SN FLQ07_09670 ENOG4105PQS phage protein FLQ07_09675 ENOG4105FR7 XkdM protein, phage-like element PBSX FLQ07_09685 ENOG4105MTC XkdN-like protein FLQ07_09695 ENOG4108FKH Transglycosylase SLT domain FLQ07_09695 ENOG4108FKH Transglycosylase SLT domain FLQ07_09700 ENOG4108WZM domain protein FLQ07_09705 ENOG4105X7F FLQ07_09715 ENOG4105MFU Protein of unknown function (DUF2634) FLQ07_09720 ENOG41066EA baseplate J family protein FLQ07_09725 ENOG410906S phage-like element pbsx protein xkdt FLQ07_09785 ENOG4108J9Q DNA ligase FLQ07_09845 ENOG4106ANW SMI1_KNR4 FLQ07_09860 ENOG41073R8 VanW family FLQ07_09880 ENOG4108RAV Conserved protein FLQ07_09890 ENOG4108X07 Tetr family transcriptional regulator FLQ07_09905 ENOG4105K78 MarR family Transcriptional regulator FLQ07_09910 ENOG4108VHC Short-chain dehydrogenase reductase Sdr FLQ07_09915 ENOG4105EBR Carboxylesterase FLQ07_09925 ENOG41087YS Phage shock protein A FLQ07_09930 ENOG4105DQX Zinc finger domain FLQ07_09935 ENOG4108WV1 Pfam:DUF477 FLQ07_09950 ENOG4108NGU Transcriptional regulator FLQ07_09955 ENOG4105N14 lysine exporter protein LysE YggA FLQ07_09965 ENOG4105CNI cell division protein FtsW FLQ07_09970 ENOG4105CNI cell division protein FtsW FLQ07_09990 ENOG4108ZJ4 polysaccharide deacetylase FLQ07_09995 ENOG4105E5K Alpha-amylase FLQ07_10000 ENOG4105FKQ transcriptional regulator FLQ07_10005 ENOG4108IUK alpha amylase, catalytic FLQ07_10010 ENOG4107FKK extracellular solute-binding protein family 1 FLQ07_10015 ENOG4105D56 permease protein FLQ07_10020 ENOG4105EG2 ABC transporter, permease FLQ07_10035 ENOG4105CG3 alpha amylase, catalytic region FLQ07_10040 ENOG4107URF beta-phospho-glucomutase FLQ07_10045 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FLQ07_10050 ENOG4105GVJ transcriptional regulator FLQ07_10100 ENOG4108W3Q Transcriptional regulator FLQ07_10105 ENOG4107STQ Multicopper oxidase FLQ07_10130 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FLQ07_10145 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FLQ07_10155 ENOG4105C7N Xanthine uracil vitamin C permease FLQ07_10170 ENOG4108U5N UPF0316 protein FLQ07_10180 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FLQ07_10185 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FLQ07_10190 ENOG4105C83 adenylosuccinate lyase FLQ07_10195 ENOG4105C8V SAICAR synthetase FLQ07_10200 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FLQ07_10210 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FLQ07_10220 ENOG4105CXB phosphoribosylaminoimidazole synthetase FLQ07_10225 ENOG4108V3E phosphoribosylglycinamide formyltransferase FLQ07_10230 ENOG4105DC1 bifunctional purine biosynthesis protein purh FLQ07_10235 ENOG4105C12 Phosphoribosylglycinamide synthetase FLQ07_10245 ENOG4106A3M Cytochrome p-450 FLQ07_10270 ENOG4108R5T secreted protein FLQ07_10275 ENOG4105KGF protein, YerC YecD FLQ07_10285 ENOG4105C4R Atp-dependent dna helicase FLQ07_10290 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FLQ07_10300 ENOG4108M21 FLQ07_10310 ENOG4105MUZ Protein of unknown function DUF2620 FLQ07_10315 ENOG4106M0N transport system permease protein FLQ07_10320 ENOG41080QX K07048 phosphotriesterase-related protein FLQ07_10325 ENOG4106PKC pyridoxal phosphate binding FLQ07_10330 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FLQ07_10335 ENOG4108626 Racemase FLQ07_10340 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FLQ07_10345 ENOG4105KT7 mgtC SapB transporter FLQ07_10350 ENOG4105CK7 Sodium proline symporter FLQ07_10355 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FLQ07_10360 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FLQ07_10365 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FLQ07_10380 ENOG4105D3P Mannan endo-1,4-beta-mannosidase FLQ07_10385 ENOG4108IG5 Transcriptional regulator FLQ07_10400 ENOG4105D9U N-acetyltransferase FLQ07_10405 ENOG4105DU0 nucleoside hydrolase FLQ07_10410 ENOG4105CBD Diacylglycerol kinase FLQ07_10415 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FLQ07_10440 ENOG4105C5Y PTS System FLQ07_10445 ENOG4105CS2 ec 3.2.1.21 FLQ07_10450 ENOG4105CID antiterminator FLQ07_10455 ENOG410780I phosphoprotein phosphatase activity FLQ07_10475 ENOG4108HFV FLQ07_10480 ENOG4107Y9U Membrane FLQ07_10490 ENOG4108PCN EamA-like transporter family FLQ07_10495 ENOG4105CDY transcriptional regulatory protein FLQ07_10510 ENOG4105C26 Dehydrogenase FLQ07_10515 ENOG4105FKZ Methyl-accepting chemotaxis FLQ07_10525 ENOG4105XEA Tetr family transcriptional regulator FLQ07_10535 ENOG4105C5H ABC transporter FLQ07_10540 ENOG4105DUM transcriptional regulator, lysR family FLQ07_10550 ENOG4105YVS arsR family transcriptional regulator FLQ07_10555 ENOG4107XZQ multidrug resistance protein FLQ07_10560 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FLQ07_10565 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase FLQ07_10575 ENOG4105CKI cobalamin synthesis protein FLQ07_10580 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) FLQ07_10585 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLQ07_10590 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FLQ07_10595 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FLQ07_10600 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FLQ07_10605 ENOG4106A3M Cytochrome p-450 FLQ07_10615 ENOG4107SWG transcriptional regulator MERR family FLQ07_10620 ENOG4105DXB Major Facilitator superfamily FLQ07_10625 ENOG4105C5H ABC transporter FLQ07_10630 ENOG4105FDU atp-dependent rna helicase FLQ07_10635 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FLQ07_10650 ENOG4107QPK )-transporter FLQ07_10695 ENOG4105VRS hydrolase family 18 FLQ07_10705 ENOG41082BM Transcriptional regulator, arsr family FLQ07_10710 ENOG410855V Acylphosphatase FLQ07_10715 ENOG4108RPX mosc domain containing protein FLQ07_10725 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FLQ07_10750 ENOG4105C5Y PTS System FLQ07_10755 ENOG4105CG3 alpha amylase, catalytic region FLQ07_10760 ENOG4107414 GntR family transcriptional regulator FLQ07_10780 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FLQ07_10785 ENOG4105D7W serine acetyltransferase FLQ07_10790 ENOG4108IAJ Nad-dependent epimerase dehydratase FLQ07_10805 ENOG4107TVC Glycosyl transferase, family 2 FLQ07_10820 ENOG4107QQG Dehydrogenase FLQ07_10830 ENOG4105KVH Transcriptional regulator FLQ07_10835 ENOG4108RCM Nitroreductase FLQ07_10840 ENOG4105CGH 5'-nucleotidase FLQ07_10845 ENOG4107RKG DJ-1/PfpI family FLQ07_10855 ENOG4105BZG amino acid carrier protein FLQ07_10860 ENOG4105KJF protein tyrosine phosphatase FLQ07_10870 ENOG4107U9T Pfam:Ribonuclease_BN FLQ07_10875 ENOG4108ISG Major Facilitator FLQ07_10885 ENOG4105UPD Calcium Proton FLQ07_10910 ENOG4105DCT glycerol dehydrogenase FLQ07_10920 ENOG4105D7N magnesium and cobalt transport protein CorA FLQ07_10930 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FLQ07_10970 ENOG41079KZ Major Facilitator Superfamily FLQ07_10995 ENOG4105EVH UPF0753 protein FLQ07_11000 ENOG4108TWJ NADH dehydrogenase subunit 5 FLQ07_11005 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FLQ07_11015 ENOG4107RUY (E1 component), alpha subunit FLQ07_11025 ENOG4107QKR Dehydrogenase FLQ07_11035 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FLQ07_11040 ENOG4105KK4 UPF0060 membrane protein FLQ07_11045 ENOG4105F8D glycoside hydrolase family 4 FLQ07_11050 ENOG4108Q3X Transcriptional regulator FLQ07_11055 ENOG4105CI1 PTS System FLQ07_11070 ENOG4105KVH Transcriptional regulator FLQ07_11080 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ07_11085 ENOG4105E4I Glycoside hydrolase family 28 FLQ07_11090 ENOG4105DSG hydrolase family 43 FLQ07_11095 ENOG4108DMH HTH_ARAC FLQ07_11105 ENOG4105DYS nad(p)h dehydrogenase (quinone) FLQ07_11125 ENOG4105JAB phenazine biosynthesis protein, phzf family FLQ07_11130 ENOG4107Y03 Nitroreductase FLQ07_11150 ENOG4105ECP epimerase FLQ07_11155 ENOG410691R Modulates RecA activity (By similarity) FLQ07_11180 ENOG4105CKK Glycosyl transferase, family 2 FLQ07_11190 ENOG4105EJV Membrane FLQ07_11195 ENOG41067AE Membrane-bound metal-dependent hydrolase FLQ07_11200 ENOG4105CEN a g-specific adenine glycosylase FLQ07_11205 ENOG4106BXE FLQ07_11210 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FLQ07_11230 ENOG4105BZ1 (ABC) transporter FLQ07_11235 ENOG4105C3U ABC transporter FLQ07_11240 ENOG4108JQ7 (ABC) transporter FLQ07_11245 ENOG4105DEF Extracellular solute-binding protein, family 5 FLQ07_11250 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ07_11255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ07_11260 ENOG4107NBY Membrane FLQ07_11265 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FLQ07_11270 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ07_11275 ENOG4105G5W regulator Fur family FLQ07_11280 ENOG4105TUA UPF0295 protein FLQ07_11530 ENOG4105CAR Terminase, large subunit FLQ07_11545 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FLQ07_11590 ENOG4108FKH Transglycosylase SLT domain FLQ07_11600 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FLQ07_11610 ENOG41068G1 FLQ07_11645 ENOG4107EV6 Inherit from COG: YD repeat protein FLQ07_11665 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FLQ07_11675 ENOG4105C22 threonyL-tRNA synthetase FLQ07_11695 ENOG4105FF2 Type I DHQase FLQ07_11700 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FLQ07_11705 ENOG4105D7T ABC transporter FLQ07_11710 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FLQ07_11715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FLQ07_11720 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FLQ07_11725 ENOG4107D63 FLQ07_11730 ENOG4105VZ8 Transcriptional regulator FLQ07_11740 ENOG4105DA5 (ABC) transporter FLQ07_11760 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FLQ07_11775 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FLQ07_11785 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FLQ07_11810 ENOG4105CYN Serine protein kinase FLQ07_11815 ENOG4106AKX UPF0229 protein FLQ07_11820 ENOG4105CW7 secretion protein, HlyD family FLQ07_11825 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ07_11830 ENOG4105CS1 NAD(P)H quinone oxidoreductase FLQ07_11840 ENOG4105CZV ABC transporter FLQ07_11845 ENOG4105CJ1 ABC, transporter FLQ07_11850 ENOG4108TU7 Inherit from COG: (ABC) transporter FLQ07_11855 ENOG4105VEQ Cold shock protein FLQ07_11860 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FLQ07_11865 ENOG4108UMI ABC transporter, permease FLQ07_11875 ENOG4107R6U sodium dicarboxylate symporter FLQ07_11905 ENOG4105BZU Histidine kinase FLQ07_11920 ENOG4108YBP pseudouridine synthase FLQ07_11930 ENOG41080XP Cbs domain FLQ07_11935 ENOG4107YBY Hydrolase FLQ07_11940 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FLQ07_11945 ENOG4105C5H ABC transporter FLQ07_11950 ENOG4105TMB Formate nitrite transporter FLQ07_11965 ENOG4105CB2 alcohol dehydrogenase FLQ07_11970 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FLQ07_11980 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FLQ07_11985 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FLQ07_12005 ENOG4105BZU Histidine kinase FLQ07_12010 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ07_12030 ENOG4105KPV Transcriptional regulator FLQ07_12035 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FLQ07_12040 ENOG4105ED1 spovr family FLQ07_12055 ENOG4105BZN citrate synthase FLQ07_12065 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FLQ07_12070 ENOG4105C8J )-transporter FLQ07_12105 ENOG41086D8 Transcriptional regulator FLQ07_12110 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ07_12125 ENOG4105J37 FLQ07_12130 ENOG4108AEY RNA polymerase sigma factor FLQ07_12135 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FLQ07_12140 ENOG4108FN7 Aldo keto reductase FLQ07_12145 ENOG4105F6E Acyl-transferase FLQ07_12150 ENOG4105KAF membrAne FLQ07_12160 ENOG4108IG5 Transcriptional regulator FLQ07_12165 ENOG4105C37 (CBS) domain FLQ07_12175 ENOG4105C37 (CBS) domain FLQ07_12205 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FLQ07_12215 ENOG4105D64 Mechanosensitive ion channel FLQ07_12220 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FLQ07_12230 ENOG4107VMI polysaccharide deacetylase FLQ07_12235 ENOG4105F0I Aminotransferase FLQ07_12245 ENOG4108N2V aldose 1-epimerase FLQ07_12275 ENOG4105BZ1 (ABC) transporter FLQ07_12280 ENOG4105BZ1 (ABC) transporter FLQ07_12315 ENOG410839P FLQ07_12325 ENOG4106MP8 UPF0754 membrane protein FLQ07_12330 ENOG4105WZB UPF0342 protein FLQ07_12345 ENOG4105D4P Coproporphyrinogen iii oxidase FLQ07_12350 ENOG4107S91 Sodium hydrogen exchanger FLQ07_12355 ENOG4105NCW Trka-c domain protein FLQ07_12365 ENOG4105CGU Enoyl-CoA hydratase FLQ07_12385 ENOG4108IUX (ABC) transporter FLQ07_12390 ENOG4105RHA ABC transporter, permease FLQ07_12395 ENOG4107VRP DNA repair exonuclease FLQ07_12400 ENOG4106D4I domain protein FLQ07_12405 ENOG4105EQI Metal Dependent Phosphohydrolase FLQ07_12415 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FLQ07_12460 ENOG4105NBU tryptophan transport protein FLQ07_12465 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FLQ07_12470 ENOG4105K59 histidine triad (HIT) protein FLQ07_12505 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FLQ07_12510 ENOG4105BZ4 penicillin-binding protein FLQ07_12515 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FLQ07_12520 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FLQ07_12525 ENOG4105C1Q protoporphyrinogen oxidase FLQ07_12535 ENOG4105ECB domain protein FLQ07_12545 ENOG4105DER m42 family FLQ07_12560 ENOG4106AXD FLQ07_12565 ENOG4108RQ5 Beta-lactamase domain-containing protein FLQ07_12570 ENOG4105DF9 Lipoate-protein, ligase FLQ07_12575 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_12585 ENOG4108JCI Transcriptional regulator FLQ07_12600 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FLQ07_12605 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ07_12610 ENOG4108UZ3 Transporter FLQ07_12615 ENOG4108HUF Transporter FLQ07_12625 ENOG4105DQ5 transport system permease protein FLQ07_12630 ENOG4108U1V ABC transporter, permease FLQ07_12635 ENOG4107TB6 phosphoglycerate mutase FLQ07_12640 ENOG4106YBV Methyl-accepting chemotaxis FLQ07_12660 ENOG4105XVF Competence transcription factor FLQ07_12665 ENOG41060YP FLQ07_12680 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ07_12695 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) FLQ07_12700 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FLQ07_12705 ENOG4105S0E allantoin catabolism protein FLQ07_12710 ENOG4105DG4 malate L-lactate dehydrogenase FLQ07_12715 ENOG4105DG4 malate L-lactate dehydrogenase FLQ07_12720 ENOG4107R1Q Membrane protein FdrA FLQ07_12725 ENOG4107REC cytoplasmic protein FLQ07_12730 ENOG4105G5A Protein of unknown function (DUF2877) FLQ07_12735 ENOG4105C5B carbamate kinase FLQ07_12740 ENOG4107SHS Involved in the efflux of sugars. The physiological role may be the reduction of the intracellular concentration of toxic sugars or sugar metabolites (By similarity) FLQ07_12745 ENOG4107CUJ Protein of unknown function (DUF2690) FLQ07_12750 ENOG410780I phosphoprotein phosphatase activity FLQ07_12770 ENOG4108KK1 membrane protein AbrB duplication FLQ07_12785 ENOG4105WEF catalase FLQ07_12790 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_12795 ENOG4106K7D Major facilitator family transporter FLQ07_12800 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FLQ07_12810 ENOG4105BZU Histidine kinase FLQ07_12815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ07_12825 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FLQ07_12830 ENOG4105E0C molybdate abc transporter FLQ07_12840 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FLQ07_12850 ENOG4105EYH Exonuclease FLQ07_12885 ENOG410751J FLQ07_12905 ENOG4105ERH Fumarylacetoacetate hydrolase FLQ07_12930 ENOG4105CAQ asparagine synthetase FLQ07_12940 ENOG4108YZA Nitrogen regulatory protein pii FLQ07_12945 ENOG4105UQX Mate efflux family protein FLQ07_12950 ENOG4106HBX Transcriptional Regulator AraC Family FLQ07_12960 ENOG4105ETE Transcriptional regulator (LacI family FLQ07_12965 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FLQ07_12980 ENOG4105E1K spore germination protein FLQ07_12985 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FLQ07_12990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FLQ07_13000 ENOG4105DY8 decarboxylase FLQ07_13025 ENOG4105MA6 gCN5-related N-acetyltransferase FLQ07_13030 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FLQ07_13035 ENOG4105D29 Helix-turn-helix type 11 domain protein FLQ07_13050 ENOG4108VPT UPF0234 protein FLQ07_13055 ENOG4105QNR S1 RNA binding domain protein FLQ07_13070 ENOG4105EPR degv family FLQ07_13075 ENOG4107AYK membrAne FLQ07_13085 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) FLQ07_13090 ENOG41073B9 FLQ07_13095 ENOG4108KP7 hydrolase FLQ07_13100 ENOG4108MXZ Esterase FLQ07_13105 ENOG4105VG1 fes assembly suf system protein FLQ07_13115 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FLQ07_13120 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) FLQ07_13125 ENOG4105CAS nag kinase FLQ07_13130 ENOG4105C8Y Acetylornithine aminotransferase FLQ07_13135 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FLQ07_13145 ENOG4105DBV ornithine carbamoyltransferase FLQ07_13150 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FLQ07_13175 ENOG4107RMD Basic membrane lipoprotein FLQ07_13190 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FLQ07_13195 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FLQ07_13205 ENOG4105C3U ABC transporter FLQ07_13225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ07_13240 ENOG4105C31 Tryptophanyl-tRNA synthetase FLQ07_13245 ENOG4108J59 Extracellular solute-binding protein, family 5 FLQ07_13250 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ07_13255 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ07_13265 ENOG4108JQ7 (ABC) transporter FLQ07_13275 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FLQ07_13280 ENOG4108ZCF integral membrane protein FLQ07_13290 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FLQ07_13315 ENOG4108V9W transcriptional regulatory protein FLQ07_13320 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FLQ07_13330 ENOG4105DPN Oligoendopeptidase f FLQ07_13340 ENOG4105T58 Dithiol-disulfide isomerase FLQ07_13345 ENOG4108Z18 K06886 hemoglobin FLQ07_13350 ENOG4105E4C Lytic transglycosylase catalytic FLQ07_13355 ENOG4105MIX Adenylate cyclase FLQ07_13360 ENOG4106EFP UPF0738 protein FLQ07_13370 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FLQ07_13375 ENOG4105EMS pseudouridine synthase FLQ07_13380 ENOG4107S1Q Phosphatase FLQ07_13390 ENOG4105ETU transcriptional activator (TenA FLQ07_13395 ENOG4108VEU Thiamine monophosphate synthase FLQ07_13410 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FLQ07_13415 ENOG4105D06 uba thif-type nad fad binding protein FLQ07_13420 ENOG4105DWF phosphomethylpyrimidine kinase FLQ07_13425 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FLQ07_13430 ENOG4107A88 FLQ07_13480 ENOG4105ENA helicase FLQ07_13490 ENOG4107T5V SNARE associated Golgi FLQ07_13495 ENOG4105CMR udp-glucose 4-epimerase FLQ07_13500 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FLQ07_13515 ENOG4108ZMI UPF0477 protein FLQ07_13540 ENOG4105C28 cystathionine FLQ07_13545 ENOG4105C28 cystathionine FLQ07_13550 ENOG4105JHY Membrane FLQ07_13565 ENOG4105FQP Beta-lactamase FLQ07_13575 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase FLQ07_13650 ENOG4108UW5 maltose o-acetyltransferase FLQ07_13660 ENOG4105DUM transcriptional regulator, lysR family FLQ07_13665 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FLQ07_13670 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FLQ07_13680 ENOG4108Q5Y Membrane FLQ07_13685 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ07_13695 ENOG41069ER domain protein FLQ07_13705 ENOG4105J7D transcriptional regulator FLQ07_13730 ENOG4105K7W phage-related replication protein FLQ07_13735 ENOG410635T phage-like element pbsx protein FLQ07_13780 ENOG4108TFU terminase (Small subunit) FLQ07_13785 ENOG4105IG6 Phage terminase, large subunit FLQ07_13790 ENOG4108MDF Phage Portal Protein FLQ07_13815 ENOG41060SN FLQ07_13830 ENOG4105PQS phage protein FLQ07_13835 ENOG4105FR7 XkdM protein, phage-like element PBSX FLQ07_13840 ENOG4105MTC XkdN-like protein FLQ07_13850 ENOG4108FKH Transglycosylase SLT domain FLQ07_13855 ENOG4108WZM domain protein FLQ07_13860 ENOG4105X7F FLQ07_13870 ENOG4105MFU Protein of unknown function (DUF2634) FLQ07_13875 ENOG41066EA baseplate J family protein FLQ07_13890 ENOG41068G1 FLQ07_13910 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FLQ07_13915 ENOG4107XBN GntR Family Transcriptional Regulator FLQ07_13920 ENOG4105CPQ Dehydrogenase FLQ07_13925 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FLQ07_13930 ENOG4105DMW Dehydrogenase reductase FLQ07_13935 ENOG4105CPQ Dehydrogenase FLQ07_13940 ENOG4108I5G Major Facilitator superfamily FLQ07_13955 ENOG4105CJ3 phosphate transporter FLQ07_13960 ENOG4107GRR phosphate transport regulator FLQ07_13965 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FLQ07_13975 ENOG4105C2F Histidine kinase FLQ07_13980 ENOG4105EQD regulatoR FLQ07_13985 ENOG410769Z extracellular solute-binding protein family 1 FLQ07_13990 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FLQ07_13995 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component FLQ07_14000 ENOG4105F5H Glycosyl Hydrolase Family 88 FLQ07_14005 ENOG41075H3 AraC family transcriptional regulator FLQ07_14010 ENOG4107TDE lipolytic protein G-D-S-L family FLQ07_14025 ENOG4105CX8 fg-gap repeat protein FLQ07_14035 ENOG4107TDE lipolytic protein G-D-S-L family FLQ07_14040 ENOG4105CX8 fg-gap repeat protein FLQ07_14050 ENOG4107TDE lipolytic protein G-D-S-L family FLQ07_14060 ENOG4105EKC FLQ07_14065 ENOG4105E0S extracellular solute-binding protein family 1 FLQ07_14075 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FLQ07_14080 ENOG4107R7I amino acid FLQ07_14090 ENOG4105C0H protease FLQ07_14100 ENOG4108ME1 Peptidase M55 D-aminopeptidase FLQ07_14105 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ07_14110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ07_14115 ENOG4105C3U ABC transporter FLQ07_14125 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FLQ07_14130 ENOG4105DTQ mandelate racemase muconate lactonizing FLQ07_14135 ENOG4107SN7 NLP P60 protein FLQ07_14140 ENOG4108JQ7 (ABC) transporter FLQ07_14145 ENOG4107TUM Amidinotransferase FLQ07_14150 ENOG4108S4H thioesterase Superfamily protein FLQ07_14160 ENOG4108J20 pectate lyase FLQ07_14185 ENOG410839T multidrug resistance protein FLQ07_14190 ENOG41080TC multidrug resistance protein FLQ07_14195 ENOG4105CIY formyltetrahydrofolate deformylase FLQ07_14200 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FLQ07_14205 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FLQ07_14215 ENOG4105K56 Transcriptional regulator FLQ07_14220 ENOG4108ZHJ Organic hydroperoxide resistance protein FLQ07_14230 ENOG4107Y2X deaminase FLQ07_14235 ENOG4105CVJ phosphoglycerate mutase FLQ07_14250 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FLQ07_14255 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ07_14265 ENOG4105CJW magnesium transporter FLQ07_14275 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FLQ07_14295 ENOG41067QW Transcriptional regulator FLQ07_14335 ENOG4108NF7 phage-type endonuclease FLQ07_14340 ENOG4108PNI recT protein FLQ07_14385 ENOG4105QBX endodeoxyribonuclease RusA FLQ07_14400 ENOG4108UUM single-stranded DNA-binding protein FLQ07_14450 ENOG4108TFU terminase (Small subunit) FLQ07_14455 ENOG4105IG6 Phage terminase, large subunit FLQ07_14585 ENOG4107EV6 Inherit from COG: YD repeat protein FLQ07_14610 ENOG4105V75 Transcriptional regulator FLQ07_14630 ENOG4105DQE DNA ligase FLQ07_14635 ENOG4105FDF Could be involved in DNA repair (By similarity) FLQ07_14640 ENOG4105BZU Histidine kinase FLQ07_14645 ENOG4107T5V SNARE associated Golgi FLQ07_14650 ENOG4107TS3 membrane protein, TerC FLQ07_14655 ENOG4108WZW RNA polymerase sigma FLQ07_14665 ENOG410681C small acid-soluble spore protein FLQ07_14675 ENOG4105D0M Protease HtpX homolog FLQ07_14685 ENOG4107RVG penicillin-binding protein FLQ07_14705 ENOG4108TGC Acyltransferase FLQ07_14710 ENOG4105BZU Histidine kinase FLQ07_14715 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FLQ07_14720 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FLQ07_14730 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FLQ07_14740 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FLQ07_14755 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FLQ07_14760 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FLQ07_14775 ENOG4105BZU Histidine kinase FLQ07_14780 ENOG41090MY MarR family Transcriptional regulator FLQ07_14785 ENOG4105ER2 Ompa motb domain protein FLQ07_14790 ENOG4105E14 MotA TolQ exbB proton channel FLQ07_14800 ENOG4108K88 Membrane FLQ07_14805 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FLQ07_14810 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FLQ07_14815 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FLQ07_14820 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FLQ07_14940 ENOG4105VTR Integrase FLQ07_14980 ENOG4105NX3 Membrane FLQ07_14985 ENOG4105VMP Transcriptional regulator FLQ07_15030 ENOG4105F0V Cell wall hydrolase FLQ07_15045 ENOG4105C59 p-type ATPase FLQ07_15050 ENOG4105DC7 peptidase M24 FLQ07_15065 ENOG4105CID antiterminator FLQ07_15075 ENOG4105KRI phosphocarrier protein (HPr FLQ07_15080 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FLQ07_15090 ENOG4105F6S Spore photoproduct lyase FLQ07_15100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FLQ07_15105 ENOG4105CHR reductase FLQ07_15110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FLQ07_15115 ENOG4105K4I Scp-like extracellular FLQ07_15125 ENOG4105BZU Histidine kinase FLQ07_15130 ENOG4105CHM Aminotransferase FLQ07_15145 ENOG4107R88 Chemotaxis protein (CheV) FLQ07_15150 ENOG4105UIN FLQ07_15160 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein FLQ07_15170 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FLQ07_15175 ENOG4105EPM Diguanylate phosphodiesterase FLQ07_15190 ENOG4107IN1 Protein of unknown function (DUF1797) FLQ07_15195 ENOG4108XRC Protein of unknown function (DUF458) FLQ07_15225 ENOG4105NQC Flavodoxin FLQ07_15230 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FLQ07_15245 ENOG4105D3R alkyl hydroperoxide reductase FLQ07_15250 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ07_15265 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FLQ07_15270 ENOG4105D06 uba thif-type nad fad binding protein FLQ07_15275 ENOG4105CVM Molybdenum cofactor synthesis domain protein FLQ07_15280 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FLQ07_15285 ENOG4108ZAF Molybdopterin FLQ07_15290 ENOG41067WU Molybdopterin converting factor (Subunit 1) FLQ07_15300 ENOG4105BZ1 (ABC) transporter FLQ07_15305 ENOG4105BZ1 (ABC) transporter FLQ07_15315 ENOG4107X8C Efflux transporter RND family MFP subunit FLQ07_15320 ENOG4105C19 ABC transporter FLQ07_15325 ENOG4107RBB ABC transporter, permease FLQ07_15330 ENOG4105E98 transcriptional regulator DeoR family FLQ07_15335 ENOG4105DE4 1-phosphofructokinase FLQ07_15340 ENOG4105DM4 PTS System FLQ07_15345 ENOG4105C3F Signal peptidase i FLQ07_15360 ENOG4105C5H ABC transporter FLQ07_15390 ENOG4105BZU Histidine kinase FLQ07_15395 ENOG4107ZYR domain protein FLQ07_15405 ENOG4105CN5 Metallo-Beta-Lactamase FLQ07_15415 ENOG4108X4Q Hydrolase FLQ07_15420 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FLQ07_15440 ENOG4105CPP Dehydrogenase, E1 component FLQ07_15445 ENOG4105C7S Dehydrogenase FLQ07_15450 ENOG4107QN2 dihydrolipoyl dehydrogenase FLQ07_15465 ENOG4105CXN decarboxylase FLQ07_15475 ENOG4105WBI UPF0223 protein FLQ07_15490 ENOG4105ECY inositol monophosphatase FLQ07_15505 ENOG4105CI3 gtp-binding protein typa FLQ07_15510 ENOG4105QA2 FLQ07_15515 ENOG4108INS Transcriptional regulator FLQ07_15520 ENOG4107SCK Monooxygenase FLQ07_15535 ENOG4108IAB Phoh family FLQ07_15545 ENOG4105CSV Glutaminase FLQ07_15550 ENOG4105ZPI UPF0358 protein FLQ07_15555 ENOG4105CNI cell division protein FtsW FLQ07_15560 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FLQ07_15570 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FLQ07_15580 ENOG4105BZ9 Cytochrome C oxidase, subunit I FLQ07_15585 ENOG4105CCU oxidase (Subunit III) FLQ07_15590 ENOG41064X9 cytochrome C oxidase subunit IV FLQ07_15605 ENOG41080XQ Signal transduction protein with cbs domains FLQ07_15610 ENOG4106UY4 Inherit from COG: Scp-like extracellular FLQ07_15635 ENOG4106H78 methyltransferase FLQ07_15640 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FLQ07_15645 ENOG4105H20 Sporulation integral membrane protein YlbJ FLQ07_15650 ENOG41063PX domain protein FLQ07_15655 ENOG4105CDE UPF0348 protein FLQ07_15660 ENOG4105KNH Nucleic acid-binding protein FLQ07_15665 ENOG41067VY 50S ribosomal protein L32 FLQ07_15685 ENOG41074B2 UPF0747 protein FLQ07_15695 ENOG4108V6E Cell division protein mraZ FLQ07_15700 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FLQ07_15710 ENOG4105CJN penicillin-binding protein FLQ07_15715 ENOG4105CJN penicillin-binding protein FLQ07_15720 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FLQ07_15725 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FLQ07_15730 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FLQ07_15735 ENOG4105CNI cell division protein FtsW FLQ07_15740 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FLQ07_15745 ENOG4105D4A Cell wall formation (By similarity) FLQ07_15750 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FLQ07_15755 ENOG4108R2U division initiation protein FLQ07_15765 ENOG4105K67 small basic protein FLQ07_15770 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FLQ07_15775 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FLQ07_15790 ENOG4105FFI sigma-e processing peptidase spoiiga FLQ07_15795 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ07_15805 ENOG4105DKW ABC transporter FLQ07_15810 ENOG4105DHI Methyltransferase FLQ07_15815 ENOG4105WR5 sporulation protein, YlmC YmxH family FLQ07_15820 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FLQ07_15825 ENOG4105DFA alanine racemase domain protein FLQ07_15830 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FLQ07_15835 ENOG41067XK integral membrane protein FLQ07_15840 ENOG4105DBK s4 domain protein FLQ07_15860 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FLQ07_15865 ENOG4105C34 Pseudouridine synthase FLQ07_15870 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FLQ07_15880 ENOG4105CXT aspartate transcarbamylase FLQ07_15885 ENOG4105CD3 dihydroorotase FLQ07_15890 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FLQ07_15895 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FLQ07_15900 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FLQ07_15905 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FLQ07_15910 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FLQ07_15925 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FLQ07_15945 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FLQ07_15950 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FLQ07_15955 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FLQ07_15960 ENOG4105F23 Fibronectin-binding protein FLQ07_15970 ENOG4105DSJ YicC domain protein FLQ07_15975 ENOG4105KC4 UPF0296 protein FLQ07_15980 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FLQ07_15985 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FLQ07_15990 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FLQ07_15995 ENOG4105C25 Primosomal protein n' FLQ07_16000 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FLQ07_16005 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FLQ07_16010 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FLQ07_16015 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FLQ07_16020 ENOG4108ZF3 Phosphatase FLQ07_16025 ENOG4105D9P serine threonine protein kinase FLQ07_16030 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FLQ07_16035 ENOG4105DJV ribulose-phosphate 3-epimerase FLQ07_16040 ENOG4105FJ0 thiamine FLQ07_16050 ENOG4105VB9 50S ribosomal protein l28 FLQ07_16055 ENOG4108ZAA Alkaline-shock protein FLQ07_16060 ENOG4105DP4 dak2 domain fusion protein ylov FLQ07_16070 ENOG4105EJQ L-serine dehydratase FLQ07_16075 ENOG4105CB5 ATP-dependent DNA helicase recG FLQ07_16080 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FLQ07_16085 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FLQ07_16090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FLQ07_16095 ENOG4105CHR reductase FLQ07_16100 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FLQ07_16105 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FLQ07_16110 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FLQ07_16115 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FLQ07_16120 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FLQ07_16130 ENOG4105K5M 30s ribosomal protein S16 FLQ07_16135 ENOG4108BW8 UPF0109 protein FLQ07_16145 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FLQ07_16150 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FLQ07_16155 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FLQ07_16160 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FLQ07_16165 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FLQ07_16175 ENOG4105VM1 flagellar FLQ07_16180 ENOG4105CMV Succinyl-CoA synthetase subunit beta FLQ07_16185 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FLQ07_16190 ENOG4105C79 DNA protecting protein DprA FLQ07_16195 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FLQ07_16200 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FLQ07_16205 ENOG4108HE4 integrase family FLQ07_16210 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FLQ07_16215 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FLQ07_16220 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) FLQ07_16225 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FLQ07_16230 ENOG4108ZC9 flagellar basal-body rod protein flgc FLQ07_16235 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FLQ07_16240 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FLQ07_16245 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FLQ07_16260 ENOG4106YF4 Flagellar biosynthesis chaperone FLQ07_16270 ENOG410696Y Flagellar hook-length control protein FLQ07_16275 ENOG410822I Flagellar hook capping protein FLQ07_16280 ENOG4108JQA flagellar FLQ07_16285 ENOG41068WV flagellar FlbD family protein FLQ07_16295 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FLQ07_16300 ENOG4105DD5 Flagellar motor switch protein FLQ07_16305 ENOG4107YTP response regulator receiver protein FLQ07_16315 ENOG4105CN7 Flagellar biosynthetic protein FliP FLQ07_16320 ENOG4105VS8 Flagellar biosynthetic protein fliq FLQ07_16325 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FLQ07_16330 ENOG4105D00 flagellar biosynthetic protein flhB FLQ07_16335 ENOG4105D7B Flagellar biosynthesis protein flha FLQ07_16340 ENOG4105FZW flagellar biosynthesis regulator FlhF FLQ07_16350 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FLQ07_16355 ENOG4105CBS Chea signal transduction histidine kinase FLQ07_16360 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FLQ07_16370 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FLQ07_16375 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ07_16385 ENOG4105CE9 30S ribosomal protein S2 FLQ07_16390 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FLQ07_16400 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FLQ07_16405 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FLQ07_16410 ENOG4105KNE Phosphatidate cytidylyltransferase FLQ07_16420 ENOG4105DZP Membrane-associated zinc metalloprotease FLQ07_16430 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FLQ07_16440 ENOG4105CYP glycoside hydrolase, family FLQ07_16455 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FLQ07_16460 ENOG4105CHV Transcription elongation factor NusA FLQ07_16465 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FLQ07_16470 ENOG4105VHM ribosomal protein FLQ07_16475 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FLQ07_16480 ENOG4105W7A Protein of unknown function (DUF503) FLQ07_16485 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FLQ07_16490 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FLQ07_16495 ENOG4105DTN riboflavin biosynthesis protein ribF FLQ07_16500 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FLQ07_16505 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FLQ07_16515 ENOG4105C1V Peptidase, M16 FLQ07_16525 ENOG4105E35 Dipicolinate synthase subunit A FLQ07_16530 ENOG4108S0H Dipicolinic acid synthetase, b subunit FLQ07_16535 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FLQ07_16545 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FLQ07_16555 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FLQ07_16565 ENOG4105CNU cell division protein FtsK FLQ07_16570 ENOG4105FDP GntR family transcriptional regulator FLQ07_16590 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FLQ07_16595 ENOG4105XZV Protein of unknown function (DUF3243) FLQ07_16610 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FLQ07_16615 ENOG4105CEV competence damage-inducible protein FLQ07_16620 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) FLQ07_16630 ENOG4105D48 metallophosphoesterase FLQ07_16635 ENOG4105MCT stage V sporulation protein S FLQ07_16640 ENOG4108IGT Dipeptidase FLQ07_16645 ENOG4105CPQ Dehydrogenase FLQ07_16650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FLQ07_16655 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FLQ07_16670 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FLQ07_16675 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FLQ07_16690 ENOG4106ANW SMI1_KNR4 FLQ07_16720 ENOG4105CKI cobalamin synthesis protein FLQ07_16730 ENOG4105G7B Protein of unknown function (DUF2992) FLQ07_16745 ENOG4105XPP Protein of unknown function (DUF1275) FLQ07_16750 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) FLQ07_16755 ENOG4108J8C transporter major facilitator family protein FLQ07_16775 ENOG41080BT SNARE associated Golgi FLQ07_16780 ENOG4105FQP Beta-lactamase FLQ07_16785 ENOG41087PP glycosyltransferase MGT family FLQ07_16790 ENOG4107QTZ amino acid FLQ07_16805 ENOG4105VRS hydrolase family 18 FLQ07_16810 ENOG4105M4P Tetr family transcriptional regulator FLQ07_16815 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein FLQ07_16830 ENOG4108X3M OsmC Ohr family protein FLQ07_16835 ENOG4107E54 Small Multidrug Resistance protein FLQ07_16855 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FLQ07_16860 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FLQ07_16875 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FLQ07_16880 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLQ07_16885 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FLQ07_16890 ENOG4105U6W MutT NUDIX family protein FLQ07_16900 ENOG4108UNV SUF system FeS assembly protein, NifU family FLQ07_16905 ENOG4105G5W regulator Fur family FLQ07_16910 ENOG4105DRR Transcriptional regulator, GntR family FLQ07_16945 ENOG4108RZE Tetr family transcriptional regulator FLQ07_16985 ENOG4106BHF FLQ07_16990 ENOG4106ANW SMI1_KNR4 FLQ07_17035 ENOG4105KI2 Urea amidohydrolase subunit beta FLQ07_17045 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) FLQ07_17050 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FLQ07_17055 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) FLQ07_17060 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) FLQ07_17070 ENOG4105U3E Transcriptional regulator FLQ07_17090 ENOG4106F1P AAA ATPase, central domain protein FLQ07_17095 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FLQ07_17100 ENOG4105CXI aluminum resistance protein FLQ07_17105 ENOG4105KV4 Transcriptional regulator FLQ07_17110 ENOG4105C5F glutamine synthetase FLQ07_17170 ENOG4105NCW Trka-c domain protein FLQ07_17175 ENOG4107S91 Sodium hydrogen exchanger FLQ07_17240 ENOG4108MK9 spermidine N(1)-acetyltransferase FLQ07_17255 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ07_17280 ENOG41062JF Transcriptional regulator FLQ07_17285 ENOG41090MY MarR family Transcriptional regulator FLQ07_17290 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FLQ07_17295 ENOG4107XWI flavin reductase domain protein, FMN-binding FLQ07_17300 ENOG4105CS1 NAD(P)H quinone oxidoreductase FLQ07_17315 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FLQ07_17320 ENOG4105WFK nuclease FLQ07_17330 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FLQ07_17340 ENOG4108SVB resolvase FLQ07_17345 ENOG4105VPS UPF0291 protein FLQ07_17350 ENOG4105CV1 Transketolase (EC 2.2.1.1) FLQ07_17360 ENOG4105VXM UPF0154 protein FLQ07_17370 ENOG4107QIV Cytochrome c biogenesis protein FLQ07_17395 ENOG41076DU acid-soluble spore protein P FLQ07_17405 ENOG4108I0Z Aconitate hydratase FLQ07_17410 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ07_17435 ENOG4105MI2 FLQ07_17450 ENOG4105W8X HesB YadR YfhF-family protein FLQ07_17455 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FLQ07_17460 ENOG4105K4P CoA-binding domain protein FLQ07_17465 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FLQ07_17475 ENOG4105CMD Transcriptional regulator, GntR family FLQ07_17490 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FLQ07_17495 ENOG4107QNK )-transporter FLQ07_17500 ENOG4105CHR reductase FLQ07_17525 ENOG4105R3A Nitrate reductase FLQ07_17530 ENOG4108IUE nitrate reductase beta subunit FLQ07_17565 ENOG4107V6Q Cyclic nucleotide-binding domain FLQ07_17585 ENOG4105DSQ Nitric oxide reductase FLQ07_17590 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FLQ07_17595 ENOG4106U2H Protein of unknown function (DUF1360) FLQ07_17600 ENOG4107QWR cellulase (EC 3.2.1.4) FLQ07_17610 ENOG4108428 Inherit from COG: -acetyltransferase FLQ07_17635 ENOG4107UWP Major facilitator superfamily MFS_1 FLQ07_17640 ENOG4108M26 parallel beta-helix repeat protein FLQ07_17670 ENOG41060WC Enoyl-CoA hydratase FLQ07_17675 ENOG4105C26 Dehydrogenase FLQ07_17680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FLQ07_17685 ENOG4105C1G acyl-Coa dehydrogenase FLQ07_17690 ENOG4105DG6 mannose-6-phosphate isomerase FLQ07_17695 ENOG4105DM4 PTS System FLQ07_17740 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FLQ07_17745 ENOG4105DMW Dehydrogenase reductase FLQ07_17750 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FLQ07_17760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FLQ07_17765 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FLQ07_17770 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FLQ07_17775 ENOG4107KJX Transcriptional regulator FLQ07_17780 ENOG4108UXE Protein tyrosine phosphatase FLQ07_17785 ENOG4107R5R arsenical pump membrane protein FLQ07_17790 ENOG41082YX Transcriptional regulator, arsr family FLQ07_17795 ENOG4105CZ9 Domain of unknown function (DU1801) FLQ07_17805 ENOG4105CSC Glucose uptake protein FLQ07_17810 ENOG4105F32 YngK protein FLQ07_17820 ENOG4105F1A Pyruvate formate-lyase FLQ07_17830 ENOG4105CGN Glycosyl transferase (Group 1 FLQ07_17835 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FLQ07_17855 ENOG4108RZE Tetr family transcriptional regulator FLQ07_17885 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FLQ07_17890 ENOG4107QX3 carboxylase FLQ07_17895 ENOG4105E39 Enoyl-CoA hydratase FLQ07_17900 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FLQ07_17905 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FLQ07_17910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FLQ07_17920 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_17925 ENOG4105C0W non-ribosomal peptide synthetase FLQ07_17935 ENOG4105C0W non-ribosomal peptide synthetase FLQ07_17940 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_17945 ENOG4105C1G acyl-Coa dehydrogenase FLQ07_17950 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FLQ07_17955 ENOG4105KVH Transcriptional regulator FLQ07_17960 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FLQ07_17965 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FLQ07_17975 ENOG4105H67 Protein of unknown function (DUF421) FLQ07_17985 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) FLQ07_17990 ENOG41061P3 phosphosulfolactate synthase FLQ07_18000 ENOG4105DIA mandelate racemase muconate lactonizing FLQ07_18005 ENOG4107RCC Major Facilitator Superfamily FLQ07_18025 ENOG4105BZ8 glutamate synthase FLQ07_18030 ENOG4105CBC glutamate synthase FLQ07_18035 ENOG4105C5Q Transcriptional regulator FLQ07_18060 ENOG4105BZ1 (ABC) transporter FLQ07_18075 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FLQ07_18080 ENOG4105C0R drug resistance transporter emrb qaca subfamily FLQ07_18085 ENOG4108J2R molybdopterin oxidoreductase FLQ07_18100 ENOG4108Q8B Spore germination protein FLQ07_18105 ENOG4108NHD germination protein FLQ07_18110 ENOG4108Q8B Spore germination protein FLQ07_18115 ENOG4108Q8B Spore germination protein FLQ07_18130 ENOG4105C8Q Methyl-accepting chemotaxis FLQ07_18135 ENOG4108Z7R Chaperone CsaA FLQ07_18140 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ07_18150 ENOG4108RZE Tetr family transcriptional regulator FLQ07_18170 ENOG4105FVX FLQ07_18190 ENOG4108W8B Beta-lactamase domain protein FLQ07_18205 ENOG4105D29 Helix-turn-helix type 11 domain protein FLQ07_18215 ENOG4105KTU Transcriptional regulator, arsr family FLQ07_18230 ENOG4105CUB amino acid FLQ07_18240 ENOG4105C5E polysaccharide biosynthesis protein FLQ07_18260 ENOG4108SJC Membrane FLQ07_18280 ENOG4107RUZ Sss sodium solute transporter superfamily FLQ07_18285 ENOG41069ER domain protein FLQ07_18290 ENOG4105C9U ATP-dependent DNA helicase RecQ FLQ07_18310 ENOG4105UNS Pfam:DUF419 FLQ07_18325 ENOG4108IEG Formate dehydrogenase Alpha subunit FLQ07_18335 ENOG4106ANW SMI1_KNR4 FLQ07_18340 ENOG4106BHF FLQ07_18350 ENOG4105UA4 acetyltransferase FLQ07_18360 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) FLQ07_18365 ENOG4106ANW SMI1_KNR4 FLQ07_18390 ENOG41068K0 YCII-related domain FLQ07_18415 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FLQ07_18430 ENOG4107S9D Alpha beta hydrolase FLQ07_18445 ENOG410829K Lysine exporter protein (Lyse ygga) FLQ07_18460 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FLQ07_18485 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FLQ07_18505 ENOG4105SCY DNAK suppressor FLQ07_18520 ENOG4105C26 Dehydrogenase FLQ07_18540 ENOG4105EWU Squalene--hopene cyclase FLQ07_18545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLQ07_18555 ENOG4105C8J )-transporter FLQ07_18560 ENOG4105C09 Bile acid FLQ07_18565 ENOG4105C7S Dehydrogenase FLQ07_18570 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FLQ07_18575 ENOG4107T89 von Willebrand factor, type A FLQ07_18580 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FLQ07_18590 ENOG4105K4H Nlp p60 protein FLQ07_18620 ENOG4105FR1 rard protein FLQ07_18630 ENOG4108YQE rare lipoprotein a FLQ07_18640 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FLQ07_18655 ENOG4105FBA Phospholipase Carboxylesterase FLQ07_18665 ENOG4105E1V na solute symporter FLQ07_18685 ENOG4108VXD carboxy-peptidase FLQ07_18690 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FLQ07_18695 ENOG4108PJD permease FLQ07_18710 ENOG4106Z5R FLQ07_18715 ENOG410841Q phosphoesterase PA-phosphatase related protein FLQ07_18730 ENOG4105VSD UPF0346 protein FLQ07_18740 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FLQ07_18745 ENOG4108TSC N-acetyltransferase FLQ07_18750 ENOG4107S4Y M20 DapE family protein YgeY FLQ07_18765 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FLQ07_18785 ENOG4105E0X reductase FLQ07_18805 ENOG4105BZU Histidine kinase FLQ07_18825 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) FLQ07_18830 ENOG41090WU lipolytic protein G-D-S-L family FLQ07_18835 ENOG4108KF3 Electron transport protein SCO1 SenC FLQ07_18855 ENOG4105C7B Threonine dehydratase FLQ07_18865 ENOG4108UT2 hemolysin iii FLQ07_18875 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FLQ07_18895 ENOG4107YX5 Pfam:DUF548 FLQ07_18905 ENOG4105C01 Dihydroxy-acid dehydratase FLQ07_18920 ENOG4108V06 Glutathione peroxidase FLQ07_18925 ENOG4105CKU formyltetrahydrofolate synthetase FLQ07_18930 ENOG4105CVG Homoserine O-transsuccinylase FLQ07_18935 ENOG4108QBV Monogalactosyldiacylglycerol synthase FLQ07_18975 ENOG41081VK Ribonuclease FLQ07_18995 ENOG410890F Dynamin family FLQ07_19010 ENOG41065KQ synthase FLQ07_19020 ENOG4105C2W permease FLQ07_19025 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) FLQ07_19030 ENOG4105CTD carboxy-peptidase FLQ07_19035 ENOG4105DVT helicase FLQ07_19055 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FLQ07_19065 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FLQ07_19070 ENOG4108UKS UPF0398 protein FLQ07_19080 ENOG4107X2U Inherit from COG: Exonuclease-like protein FLQ07_19085 ENOG4108I5C dEAD DEAH box helicase FLQ07_19135 ENOG4105BZ4 penicillin-binding protein FLQ07_19145 ENOG4105CSM endonuclease III FLQ07_19160 ENOG4105CHM Aminotransferase FLQ07_19170 ENOG4105YAC FLQ07_19175 ENOG4105DVT helicase FLQ07_19180 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FLQ07_19185 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FLQ07_19190 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FLQ07_19205 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FLQ07_19210 ENOG4105CPK Glycosyl transferase (Group 1 FLQ07_19215 ENOG4105FJR Lmbe family FLQ07_19220 ENOG4108Z5K methylglyoxal synthase FLQ07_19225 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FLQ07_19230 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FLQ07_19235 ENOG4108JYZ YitT family FLQ07_19255 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FLQ07_19270 ENOG4108SXZ UPF0302 protein FLQ07_19275 ENOG41068YB TPR repeat-containing protein FLQ07_19290 ENOG4105CIH Imidazole acetol-phosphate transaminase FLQ07_19295 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FLQ07_19300 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FLQ07_19310 ENOG4105DK0 Indole-3-glycerol phosphate synthase FLQ07_19315 ENOG4108I0Q anthranilate phosphoribosyltransferase FLQ07_19320 ENOG4105CRQ synthase (Component I) FLQ07_19325 ENOG4105KHN chorismate mutase FLQ07_19330 ENOG4105D49 3-dehydroquinate synthase FLQ07_19335 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FLQ07_19340 ENOG4105BZU Histidine kinase FLQ07_19345 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FLQ07_19350 ENOG4105EAH synthase FLQ07_19355 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FLQ07_19360 ENOG4105XXQ heptaprenyl diphosphate synthase component I FLQ07_19370 ENOG4105EUJ GTP cyclohydrolase i FLQ07_19375 ENOG4105K70 DNA-binding protein FLQ07_19380 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FLQ07_19400 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FLQ07_19405 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FLQ07_19410 ENOG41065D1 FLQ07_19415 ENOG4105S2F FLQ07_19430 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) FLQ07_19435 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FLQ07_19440 ENOG4105CAT Cytidine monophosphate kinase FLQ07_19445 ENOG4105MSI germination protein ypeb FLQ07_19460 ENOG4105HDK L-asparaginase FLQ07_19465 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FLQ07_19480 ENOG4107RGJ metallophosphoesterase FLQ07_19495 ENOG4105I7S Abortive infection protein FLQ07_19500 ENOG4105C9U ATP-dependent DNA helicase RecQ FLQ07_19505 ENOG4105T7X FLQ07_19515 ENOG4108SAX Membrane FLQ07_19520 ENOG4108JQ1 Dehydrogenase FLQ07_19525 ENOG4105DR5 peptidase FLQ07_19540 ENOG4108KGH TRANSCRIPTIONal FLQ07_19555 ENOG4105US7 Histidine kinase FLQ07_19560 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ07_19565 ENOG4105BZU Histidine kinase FLQ07_19570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ07_19575 ENOG4105CRE cytochrome C FLQ07_19580 ENOG4107TWT Cytochrome c biogenesis protein FLQ07_19585 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FLQ07_19590 ENOG4105FE9 pseudouridine synthase FLQ07_19600 ENOG4108JIC nucleoside recognition domain protein FLQ07_19605 ENOG4105DZ1 carboxypeptidase FLQ07_19615 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FLQ07_19620 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FLQ07_19640 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FLQ07_19645 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FLQ07_19650 ENOG4108R6K riboflavin synthase, subunit alpha FLQ07_19655 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FLQ07_19665 ENOG4105MEW serine threonine protein phosphatase FLQ07_19680 ENOG4107ZE5 PPIases accelerate the folding of proteins FLQ07_19685 ENOG4105PTM secreted protein FLQ07_19690 ENOG4105K7W phage-related replication protein FLQ07_19695 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FLQ07_19710 ENOG4105G6R Stage v sporulation protein ae FLQ07_19720 ENOG4105CZ3 stage V sporulation protein ad FLQ07_19725 ENOG41090VF Stage v sporulation protein ac FLQ07_19740 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ07_19745 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FLQ07_19750 ENOG41082AN stage II sporulation protein FLQ07_19755 ENOG4105DZ1 carboxypeptidase FLQ07_19760 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FLQ07_19765 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FLQ07_19770 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FLQ07_19780 ENOG4105I3K Ferric uptake regulator, Fur family FLQ07_19785 ENOG4105MZ9 stage II sporulation protein m FLQ07_19790 ENOG4105CK1 PTS System FLQ07_19800 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FLQ07_19815 ENOG4107YB6 acetyltransferase, (GNAT) family FLQ07_19825 ENOG4108YZ4 nudix hydrolase FLQ07_19835 ENOG4105PF9 Transcriptional regulator FLQ07_19845 ENOG4105CPC Aldo Keto reductase FLQ07_19865 ENOG4106HZJ FLQ07_19875 ENOG4105RHY Pfam:UPF0157 FLQ07_19880 ENOG4105KAC Antibiotic biosynthesis monooxygenase FLQ07_19885 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FLQ07_19895 ENOG4107RRN ABC transporter substrate-binding protein FLQ07_19900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ07_19905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ07_19920 ENOG4107R73 Mate efflux family protein FLQ07_19935 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FLQ07_19945 ENOG4105E5W Transporter FLQ07_19950 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase FLQ07_19970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FLQ07_20000 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ07_20035 ENOG4105K7W phage-related replication protein FLQ07_20045 ENOG4108IXY short-chain dehydrogenase reductase FLQ07_20050 ENOG41069FQ Metallo-beta-lactamase superfamily FLQ07_20055 ENOG4105II7 pyrroline-5-carboxylate reductase FLQ07_20065 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FLQ07_20075 ENOG4105WDJ 50S ribosomal protein L33 FLQ07_20080 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FLQ07_20085 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FLQ07_20105 ENOG4108TZY GntR Family Transcriptional Regulator FLQ07_20110 ENOG4105CS2 ec 3.2.1.21 FLQ07_20115 ENOG4105CK1 PTS System FLQ07_20120 ENOG4105VCP PTS System FLQ07_20125 ENOG4105VZJ PTS System FLQ07_20130 ENOG4105G6Z alkaline phosphatase FLQ07_20135 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FLQ07_20140 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FLQ07_20145 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FLQ07_20155 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) FLQ07_20160 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FLQ07_20165 ENOG4108HNZ carboxyl transferase FLQ07_20175 ENOG4108QEG Membrane FLQ07_20180 ENOG4105CDA abc transporter atp-binding protein FLQ07_20185 ENOG4105E5Q amino acid AbC transporter FLQ07_20190 ENOG4108HW3 (ABC) transporter FLQ07_20195 ENOG4108Y6J UPF0403 protein FLQ07_20200 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FLQ07_20205 ENOG4105C7S Dehydrogenase FLQ07_20210 ENOG4105CPP Dehydrogenase, E1 component FLQ07_20225 ENOG4105CKM Branched-chain carboxylic acid kinase FLQ07_20230 ENOG4107RDP Dehydrogenase FLQ07_20240 ENOG4108JUB Transcriptional regulator FLQ07_20245 ENOG4106CCJ Protein of unknown function (DUF2627) FLQ07_20250 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FLQ07_20255 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ07_20280 ENOG4107QQR Sporulation FLQ07_20285 ENOG4105S1Z Stage IV sporulation protein B FLQ07_20290 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FLQ07_20295 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FLQ07_20300 ENOG4105DX0 Hemolysin A FLQ07_20305 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FLQ07_20310 ENOG4105CTB Polyprenyl synthetase FLQ07_20315 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FLQ07_20320 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FLQ07_20325 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FLQ07_20330 ENOG4105M7K Involved in the transcription termination process (By similarity) FLQ07_20335 ENOG4108ZSR alkaline shock protein FLQ07_20340 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FLQ07_20360 ENOG410644B Stage III sporulation protein af FLQ07_20370 ENOG4105KQ4 Stage iii sporulation protein ad FLQ07_20375 ENOG4108CQH stage III sporulation protein AC FLQ07_20380 ENOG4105KR5 Stage iii sporulation protein FLQ07_20385 ENOG4105CD2 stage iii sporulation protein aa FLQ07_20395 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FLQ07_20400 ENOG4105DC7 peptidase M24 FLQ07_20405 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FLQ07_20415 ENOG4105CBJ Metal-dependent enzyme FLQ07_20430 ENOG4105KST dependent repressor FLQ07_20435 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FLQ07_20440 ENOG4105WZW rhodanese family FLQ07_20450 ENOG4107SQ8 Glycine betaine FLQ07_20455 ENOG4108IJ7 Glycine betaine FLQ07_20460 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FLQ07_20470 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FLQ07_20475 ENOG4105C0D helicase FLQ07_20500 ENOG4105VFR signal peptidase FLQ07_20540 ENOG4106855 Competence protein FLQ07_20615 ENOG410906S phage-like element pbsx protein xkdt FLQ07_20620 ENOG41066EA baseplate J family protein FLQ07_20625 ENOG4105MFU Protein of unknown function (DUF2634) FLQ07_20635 ENOG4105X7F FLQ07_20640 ENOG4108WZM domain protein FLQ07_20645 ENOG4108FKH Transglycosylase SLT domain FLQ07_20645 ENOG4108FKH Transglycosylase SLT domain FLQ07_20655 ENOG4105MTC XkdN-like protein FLQ07_20665 ENOG4105FR7 XkdM protein, phage-like element PBSX FLQ07_20670 ENOG4105PQS phage protein FLQ07_20685 ENOG41060SN FLQ07_20720 ENOG4106CGH Phage Mu protein F like protein FLQ07_20725 ENOG4108MDF Phage Portal Protein FLQ07_20730 ENOG4105IG6 Phage terminase, large subunit FLQ07_20760 ENOG4107EV6 Inherit from COG: YD repeat protein FLQ07_20790 ENOG4105UA4 acetyltransferase FLQ07_20810 ENOG4105QBX endodeoxyribonuclease RusA FLQ07_20825 ENOG4105CDU Replicative dna helicase FLQ07_20840 ENOG4108PNI recT protein FLQ07_20845 ENOG4108NF7 phage-type endonuclease FLQ07_20890 ENOG410635T phage-like element pbsx protein FLQ07_20935 ENOG4105C5X domain protein FLQ07_20965 ENOG4105E0M Sulfatase FLQ07_20985 ENOG4107ZXI Rhomboid family FLQ07_20990 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FLQ07_20995 ENOG4105WDJ 50S ribosomal protein L33 FLQ07_21015 ENOG41068DG YceG-like family FLQ07_21065 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FLQ07_21070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FLQ07_21075 ENOG4105E2Z phosphate ABC transporter (Permease FLQ07_21080 ENOG4105C8U phosphate abc transporter FLQ07_21085 ENOG4105CVA phosphate FLQ07_21090 ENOG4107RF6 penicillin-binding protein FLQ07_21105 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FLQ07_21110 ENOG4105SXS Protein of unknown function (DUF456) FLQ07_21125 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FLQ07_21130 ENOG41063Y9 FLQ07_21135 ENOG4108U5J '-nucleotidase FLQ07_21140 ENOG4105N80 Ferric uptake regulator, Fur family FLQ07_21145 ENOG4105FAV ABC, transporter FLQ07_21150 ENOG4105FDK ABC transporter FLQ07_21155 ENOG4108JYZ YitT family FLQ07_21160 ENOG41069ZM Protein of unknown function (DUF2624) FLQ07_21165 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FLQ07_21180 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FLQ07_21185 ENOG4105EGD dinuclear metal center protein, YbgI family FLQ07_21195 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) FLQ07_21235 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ07_21240 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FLQ07_21250 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FLQ07_21260 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FLQ07_21265 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FLQ07_21270 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) FLQ07_21280 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FLQ07_21285 ENOG4105KG3 cytidine deaminase FLQ07_21290 ENOG4107YR5 Diacylglycerol kinase FLQ07_21295 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FLQ07_21300 ENOG4105CTJ Metal Dependent Phosphohydrolase FLQ07_21305 ENOG4105C9A Phoh family FLQ07_21310 ENOG4105EI1 sporulation protein yqfd FLQ07_21315 ENOG41068P3 sporulation protein YqfC FLQ07_21325 ENOG4105DI5 UPF0365 protein FLQ07_21330 ENOG4105F7J membrane-bound serine protease FLQ07_21335 ENOG4105KTH gatB Yqey FLQ07_21340 ENOG4105VCC 30S ribosomal protein S21 FLQ07_21350 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FLQ07_21355 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FLQ07_21360 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FLQ07_21365 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FLQ07_21370 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FLQ07_21375 ENOG4105CFG Acts as a chaperone (By similarity) FLQ07_21380 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FLQ07_21385 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FLQ07_21390 ENOG4105CSA Coproporphyrinogen iii oxidase FLQ07_21395 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FLQ07_21405 ENOG4108ZRV stage ii sporulation protein p FLQ07_21425 ENOG4105KVH Transcriptional regulator FLQ07_21430 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FLQ07_21435 ENOG4105TQK DNA polymerase iii, delta' subunit FLQ07_21445 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FLQ07_21450 ENOG4108UK2 deaminase FLQ07_21455 ENOG4105KQC Competence protein FLQ07_21465 ENOG4108D32 Methyltransferase FLQ07_21475 ENOG4108WF2 Metal Dependent Phosphohydrolase FLQ07_21480 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FLQ07_21485 ENOG410812S Rna-binding protein FLQ07_21490 ENOG4105E2X shikimate dehydrogenase FLQ07_21495 ENOG4105CQW ribosome biogenesis GTPase YqeH FLQ07_21500 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FLQ07_21520 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FLQ07_21525 ENOG4108JB9 formate dehydrogenase FLQ07_21545 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FLQ07_21580 ENOG4108SWU Histidine kinase FLQ07_21585 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ07_21590 ENOG4105DHF Membrane FLQ07_21600 ENOG4108UYN gCN5-related N-acetyltransferase FLQ07_21605 ENOG4108HCJ Hydrolase FLQ07_21610 ENOG4105F8D glycoside hydrolase family 4 FLQ07_21620 ENOG4105DJ2 Major Facilitator Superfamily FLQ07_21635 ENOG4108Z5V transcriptional regulator, merr family FLQ07_21650 ENOG4105C7F AcnD-accessory protein PrpF FLQ07_21665 ENOG4105R3A Nitrate reductase FLQ07_21670 ENOG4108IUE nitrate reductase beta subunit FLQ07_21695 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FLQ07_21705 ENOG4105WH1 Two component transcriptional regulator luxr family FLQ07_21710 ENOG4105BZU Histidine kinase FLQ07_21715 ENOG4105XXY Thioredoxin FLQ07_21720 ENOG41087NI Sulfite exporter TauE/SafE FLQ07_21725 ENOG4105VFE sira family FLQ07_21735 ENOG4105VFE sira family FLQ07_21740 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FLQ07_21745 ENOG4105XTG Pfam:DUF156 FLQ07_21780 ENOG41090U3 tautomerase FLQ07_21785 ENOG41080HJ 6-phospho 3-hexuloisomerase FLQ07_21790 ENOG4108VA3 3-hexulose-6-phosphate synthase FLQ07_21795 ENOG4105KVH Transcriptional regulator FLQ07_21800 ENOG4105ECK Fatty Acid Desaturase FLQ07_21805 ENOG4108ZGX Histidine kinase FLQ07_21810 ENOG4108S01 response regulator FLQ07_21815 ENOG4105CAY ferredoxin--nadp reductase FLQ07_21820 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FLQ07_21825 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FLQ07_21830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FLQ07_21840 ENOG4108JQ7 (ABC) transporter FLQ07_21855 ENOG4108ZX5 transcriptional regulator FLQ07_21860 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FLQ07_21880 ENOG4105DSG hydrolase family 43 FLQ07_21885 ENOG4105CT4 transporter FLQ07_21895 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FLQ07_21900 ENOG4108HKT sucrose-6-phosphate hydrolase FLQ07_21905 ENOG4105F3R pts system mannose fructose sorbose family iid FLQ07_21910 ENOG4105ETZ PTS System FLQ07_21915 ENOG4108IQ3 PTS system FLQ07_21920 ENOG4105YHU PTS system FLQ07_21925 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FLQ07_21935 ENOG4105WDR FLQ07_21950 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FLQ07_21960 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) FLQ07_21965 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FLQ07_21970 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) FLQ07_21980 ENOG4105CV8 reductase FLQ07_21985 ENOG4105F27 Major Facilitator FLQ07_21990 ENOG4105KVH Transcriptional regulator FLQ07_21995 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) FLQ07_22000 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FLQ07_22010 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FLQ07_22015 ENOG4107RSM transcriptional regulator FLQ07_22020 ENOG4105D94 Major Facilitator Superfamily FLQ07_22030 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FLQ07_22035 ENOG41082JN Transcriptional regulator FLQ07_22040 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FLQ07_22065 ENOG4105C28 cystathionine FLQ07_22075 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FLQ07_22080 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FLQ07_22095 ENOG4107XRG penicillin-binding protein FLQ07_22100 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FLQ07_22110 ENOG4105CFP Peptidase U32 FLQ07_22115 ENOG4105XYU peptidase (U32 family) FLQ07_22120 ENOG4108VQJ O-methyltransferase FLQ07_22125 ENOG4105HHA aminodeoxychorismate lyase FLQ07_22130 ENOG4105VPH UPF0473 protein FLQ07_22135 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FLQ07_22140 ENOG4105VBH UPF0297 protein FLQ07_22145 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FLQ07_22150 ENOG4105C02 permease FLQ07_22160 ENOG41060CR FLQ07_22170 ENOG4105C7H Helicase, RecD TraA family FLQ07_22180 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FLQ07_22185 ENOG4105C3J Cysteine desulfurase FLQ07_22195 ENOG4105D1H recombination factor protein RarA FLQ07_22200 ENOG4105CUZ uba thif-type nad fad binding protein FLQ07_22210 ENOG4105C9M aspartyl-trna synthetase FLQ07_22215 ENOG4105CUT histidyl-tRNA synthetase FLQ07_22220 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FLQ07_22225 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FLQ07_22230 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FLQ07_22235 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FLQ07_22240 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FLQ07_22245 ENOG41067VP Protein of unknown function (DUF1049) FLQ07_22250 ENOG4105NCW Trka-c domain protein FLQ07_22255 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FLQ07_22265 ENOG4105CKP Polysaccharide Biosynthesis Protein FLQ07_22270 ENOG4108QG2 Membrane FLQ07_22275 ENOG4105NAP FLQ07_22280 ENOG4105VIE preprotein translocase, subunit YajC FLQ07_22285 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FLQ07_22290 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FLQ07_22295 ENOG41061AI Protein of unknown function (DUF2905) FLQ07_22300 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FLQ07_22305 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FLQ07_22335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FLQ07_22340 ENOG41069DP small acid-soluble spore protein FLQ07_22350 ENOG4105K7W phage-related replication protein FLQ07_22365 ENOG4105CDY transcriptional regulatory protein FLQ07_22375 ENOG4106678 morphogenetic protein associated with SpoVID FLQ07_22380 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FLQ07_22385 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FLQ07_22390 ENOG4108IYU L-aspartate oxidase FLQ07_22405 ENOG4105CQC Prephenate dehydratase FLQ07_22410 ENOG41090I5 UPF0735 ACT domain-containing protein FLQ07_22415 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FLQ07_22425 ENOG4105K46 50S ribosomal protein l27 FLQ07_22430 ENOG4105X36 (ribosomal) protein FLQ07_22435 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FLQ07_22455 ENOG41082BM Transcriptional regulator, arsr family FLQ07_22460 ENOG4107QMS site-determining protein FLQ07_22465 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FLQ07_22470 ENOG4105YHC Rod shape-determining protein MreD FLQ07_22475 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FLQ07_22480 ENOG4105DFF Rod shape-determining protein mreb FLQ07_22485 ENOG4105W5Q DNA repair protein (RadC FLQ07_22490 ENOG4108Z03 MAF-like protein FLQ07_22500 ENOG4106A3R peptidase FLQ07_22505 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FLQ07_22510 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FLQ07_22520 ENOG4106AR7 Spore coat protein FLQ07_22525 ENOG41068KH stage VI sporulation protein D FLQ07_22530 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FLQ07_22535 ENOG4105D52 delta-aminolevulinic acid dehydratase FLQ07_22545 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FLQ07_22555 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FLQ07_22565 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FLQ07_22570 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FLQ07_22575 ENOG4108IUQ atp-dependent protease FLQ07_22580 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FLQ07_22585 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FLQ07_22595 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FLQ07_22600 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FLQ07_22605 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FLQ07_22610 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FLQ07_22615 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FLQ07_22620 ENOG4108ZP8 Acetolactate synthase small subunit FLQ07_22625 ENOG4105C7K acetolactate synthase FLQ07_22630 ENOG4105CM2 brancheD-chain amino acid aminotransferase FLQ07_22640 ENOG4107R37 Glutamate dehydrogenase FLQ07_22660 ENOG4105M59 Phosphodiesterase, mj0936 family FLQ07_22665 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FLQ07_22670 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FLQ07_22675 ENOG4108XJQ germination protein FLQ07_22680 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FLQ07_22685 ENOG41067TZ transcriptional regulator, MarR family FLQ07_22690 ENOG4105PFC Transcriptional regulator FLQ07_22695 ENOG4105EMU Dehydrogenase FLQ07_22705 ENOG4105E33 succinate dehydrogenase FLQ07_22715 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FLQ07_22725 ENOG4105CFH Aspartokinase FLQ07_22735 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FLQ07_22740 ENOG4105K63 Thioredoxin FLQ07_22745 ENOG4105C10 Electron transfer flavoprotein FLQ07_22750 ENOG4105BZJ Electron transfer flavoprotein FLQ07_22755 ENOG41060WC Enoyl-CoA hydratase FLQ07_22760 ENOG4107Z3H Transcriptional regulator, TetR family FLQ07_22765 ENOG4105CEY Amp-dependent synthetase and ligase FLQ07_22775 ENOG4105C98 muts2 protein FLQ07_22780 ENOG4105DCG PHP domain protein FLQ07_22790 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FLQ07_22795 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FLQ07_22810 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FLQ07_22815 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FLQ07_22820 ENOG4108RWN rrna methyltransferase FLQ07_22825 ENOG41067MF small acid-soluble spore protein FLQ07_22835 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FLQ07_22840 ENOG410905X membrane-flanked domain protein FLQ07_22860 ENOG4105DRS transport system, permease FLQ07_22875 ENOG4108MDK Dehydrogenase FLQ07_22880 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FLQ07_22885 ENOG4105EF1 ribulokinase FLQ07_22890 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FLQ07_22900 ENOG4105CN9 Peptidase m42 family protein FLQ07_22910 ENOG410696E Membrane FLQ07_22915 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FLQ07_22920 ENOG4105VJV 50s ribosomal protein L35 FLQ07_22925 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FLQ07_22930 ENOG41067MG lrgb family FLQ07_22940 ENOG4105DGI Alkaline phosphatase FLQ07_22945 ENOG4105DY9 regulatoR FLQ07_22950 ENOG4108HRK Histidine kinase FLQ07_22960 ENOG4105U0R haloacid dehalogenase-like hydrolase FLQ07_22965 ENOG4105C22 threonyL-tRNA synthetase FLQ07_22970 ENOG4108TDW sporulation protein YtxC FLQ07_22990 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FLQ07_23005 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FLQ07_23010 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FLQ07_23015 ENOG4108NR7 pectate lyase FLQ07_23020 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FLQ07_23030 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FLQ07_23035 ENOG4105C2M dna polymerase I FLQ07_23040 ENOG4105BZU Histidine kinase FLQ07_23045 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FLQ07_23050 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FLQ07_23055 ENOG4108HMX isocitrate dehydrogenase (NADP) FLQ07_23060 ENOG4105BZN citrate synthase FLQ07_23065 ENOG4108RZ2 Glycoside hydrolase family 16 FLQ07_23075 ENOG4108VMM UPF0756 membrane protein FLQ07_23080 ENOG4108REF Sporulation integral membrane protein ytvi FLQ07_23085 ENOG4105FS0 cytoplasmic membrane protein FLQ07_23090 ENOG4105CA9 Pyruvate kinase FLQ07_23095 ENOG4105CTQ phosphohexokinase FLQ07_23100 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FLQ07_23110 ENOG4105C6K Malic enzyme FLQ07_23115 ENOG4105C0B DNA polymerase III (alpha subunit) FLQ07_23120 ENOG4105VV2 FLQ07_23130 ENOG4106EVM FLQ07_23135 ENOG4105SFS phosphoesterase RecJ domain protein FLQ07_23150 ENOG4105U3E Transcriptional regulator FLQ07_23155 ENOG4105E8R UPF0173 metal-dependent hydrolase FLQ07_23165 ENOG4105CH7 arginosuccinase FLQ07_23170 ENOG4105CDH Citrulline--aspartate ligase FLQ07_23175 ENOG4105EPU Molybdenum cofactor synthesis domain protein FLQ07_23180 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FLQ07_23190 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FLQ07_23195 ENOG4105KBJ sporulation protein ytfj FLQ07_23205 ENOG4105VK3 rdd domain containing protein FLQ07_23210 ENOG4105D07 Signal peptide peptidase, SppA FLQ07_23220 ENOG41061AU MarR family Transcriptional regulator FLQ07_23225 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FLQ07_23235 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FLQ07_23260 ENOG4105U5Y Transcriptional regulator FLQ07_23270 ENOG4105BZU Histidine kinase FLQ07_23275 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FLQ07_23290 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FLQ07_23300 ENOG4105F1V Acetoin utilization protein FLQ07_23305 ENOG4105W87 Cbs domain FLQ07_23310 ENOG4105DGU Histone deacetylase FLQ07_23315 ENOG4105ER2 Ompa motb domain protein FLQ07_23320 ENOG4107R0U MotA TolQ exbB proton channel FLQ07_23325 ENOG4105ETE Transcriptional regulator (LacI family FLQ07_23330 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FLQ07_23400 ENOG4105K4H Nlp p60 protein FLQ07_23415 ENOG4105KRN Transcriptional regulator, abrb family FLQ07_23445 ENOG4108UUM single-stranded DNA-binding protein