locus-tag	class	description
D5285_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D5285_00010	COG0592	DNA-directed DNA polymerase activity
D5285_00015	COG2501	S4 domain
D5285_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D5285_00030	COG0187	DNA topoisomerase II activity
D5285_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5285_00070	COG0517	IMP dehydrogenase activity
D5285_00070	COG0516	GMP reductase activity
D5285_00075	COG1686	Belongs to the peptidase S11 family
D5285_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D5285_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D5285_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D5285_00095	COG1929	Belongs to the glycerate kinase type-1 family
D5285_00100	COG2610	gluconate transmembrane transporter activity
D5285_00105	COG3835	regulator
D5285_00120	COG1428	Deoxynucleoside kinase
D5285_00125	COG1428	Deoxynucleoside kinase
D5285_00130	COG1388	LysM domain
D5285_00130	COG3858	chitin binding
D5285_00135	COG1335	isochorismatase
D5285_00140	COG0590	tRNA wobble adenosine to inosine editing
D5285_00150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D5285_00155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D5285_00160	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D5285_00205	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D5285_00210	COG3853	Toxic anion resistance protein (TelA)
D5285_00215	COG1982	Orn Lys Arg decarboxylase major
D5285_00220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D5285_00225	COG3870	Protein conserved in bacteria
D5285_00230	COG1728	Protein conserved in bacteria
D5285_00235	COG0470	DNA polymerase III
D5285_00240	COG1774	PSP1 C-terminal conserved region
D5285_00245	COG4467	Involved in initiation control of chromosome replication
D5285_00250	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D5285_00255	COG2827	Endonuclease containing a URI domain
D5285_00260	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D5285_00265	COG2002	toxin-antitoxin pair type II binding
D5285_00270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5285_00270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5285_00275	COG0084	hydrolase, TatD family'
D5285_00280	COG3584	3D domain protein
D5285_00280	COG3583	domain protein
D5285_00285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D5285_00290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D5285_00300	COG4466	Protein conserved in bacteria
D5285_00310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D5285_00315	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5285_00320	COG0251	oxidation-reduction process
D5285_00325	COG2088	sporulation resulting in formation of a cellular spore
D5285_00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D5285_00335	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D5285_00340	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D5285_00345	COG0193	aminoacyl-tRNA hydrolase activity
D5285_00355	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D5285_00360	COG2002	toxin-antitoxin pair type II binding
D5285_00365	COG2244	polysaccharide biosynthetic process
D5285_00370	COG3956	TIGRFAM MazG family protein
D5285_00375	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D5285_00390	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D5285_00395	COG1098	S1 RNA binding domain
D5285_00410	COG2208	phosphoserine phosphatase activity
D5285_00415	COG2304	oxidoreductase activity
D5285_00420	COG0515	serine threonine protein kinase
D5285_00425	COG0037	tRNA processing
D5285_00435	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5285_00440	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D5285_00445	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D5285_00450	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5285_00455	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5285_00465	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5285_00470	COG0512	Glutamine amidotransferase of anthranilate synthase
D5285_00475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5285_00480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D5285_00485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D5285_00490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D5285_00495	COG1396	sequence-specific DNA binding
D5285_00500	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D5285_00505	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D5285_00525	COG4463	regulation of RNA biosynthetic process
D5285_00530	COG3880	PFAM UvrB UvrC protein
D5285_00535	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D5285_00540	COG0542	response to heat
D5285_00545	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D5285_00550	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D5285_00555	COG4956	integral membrane protein (PIN domain superfamily)
D5285_00560	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D5285_00565	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D5285_00570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D5285_00575	COG1045	serine acetyltransferase
D5285_00580	COG0215	cysteine-tRNA ligase activity
D5285_00585	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D5285_00590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5285_00595	COG3688	RNA-binding protein containing a PIN domain
D5285_00615	COG0250	Participates in transcription elongation, termination and antitermination
D5285_00620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D5285_00625	COG0081	regulation of translation
D5285_00630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D5285_00635	COG0222	ribosome binding
D5285_00640	COG2813	Specifically methylates the guanine in position
D5285_00645	COG0085	RNA polymerase activity
D5285_00650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D5285_00655	COG1358	cellular component organization or biogenesis
D5285_00660	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D5285_00665	COG0049	tRNA binding
D5285_00670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D5285_00675	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D5285_00680	COG0051	transcription antitermination factor activity, RNA binding
D5285_00685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D5285_00690	COG0088	Forms part of the polypeptide exit tunnel
D5285_00695	COG0089	rRNA binding
D5285_00705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D5285_00710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D5285_00715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D5285_00720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D5285_00725	COG0255	Belongs to the universal ribosomal protein uL29 family
D5285_00730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D5285_00735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D5285_00740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D5285_00745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D5285_00750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5285_00755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D5285_00760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D5285_00765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D5285_00770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D5285_00775	COG1841	ribosomal large subunit assembly
D5285_00780	COG0200	Binds to the 23S rRNA
D5285_00785	COG0201	protein transport
D5285_00790	COG0563	adenylate kinase activity
D5285_00795	COG0024	Methionine aminopeptidase
D5285_00800	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D5285_00805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D5285_00810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D5285_00815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D5285_00820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D5285_00825	COG0202	RNA polymerase activity
D5285_00830	COG0203	ribosomal protein L17
D5285_00835	COG1122	ATPase activity
D5285_00840	COG1122	ATPase activity
D5285_00845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D5285_00850	COG0101	tRNA pseudouridine synthase activity
D5285_00855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D5285_00860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D5285_00890	COG2318	DinB family
D5285_00910	COG1131	(ABC) transporter
D5285_00940	COG2274	protein secretion by the type I secretion system
D5285_00965	COG3290	protein histidine kinase activity
D5285_00990	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5285_00995	COG0489	protein tyrosine kinase activity
D5285_01005	COG2194	sulfuric ester hydrolase activity
D5285_01010	COG0726	polysaccharide deacetylase
D5285_01040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5285_01050	COG0385	Bile acid
D5285_01065	COG3876	Protein conserved in bacteria
D5285_01070	COG1472	Belongs to the glycosyl hydrolase 3 family
D5285_01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5285_01080	COG1263	PTS System
D5285_01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_01085	COG1737	Transcriptional regulator
D5285_01090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5285_01095	COG1683	Conserved Protein
D5285_01130	COG1595	DNA-templated transcription, initiation
D5285_01135	COG5662	AntiSigma factor
D5285_01140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D5285_01145	COG4856	YbbR-like protein
D5285_01150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5285_01155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D5285_01175	COG1725	Transcriptional regulator
D5285_01180	COG0640	Transcriptional regulator
D5285_01190	COG2814	Major facilitator Superfamily
D5285_01195	COG1309	transcriptional regulator
D5285_01210	COG1132	(ABC) transporter
D5285_01215	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D5285_01225	COG1132	(ABC) transporter
D5285_01230	COG2312	Erythromycin esterase
D5285_01250	COG1011	Hydrolase
D5285_01270	COG2211	Major facilitator Superfamily
D5285_01290	COG1331	Highly conserved protein containing a thioredoxin domain
D5285_01295	COG0697	spore germination
D5285_01300	COG0789	Transcriptional regulator
D5285_01330	COG2226	methyltransferase
D5285_01335	COG0076	glutamate decarboxylase activity
D5285_01340	COG0778	Nitroreductase
D5285_01345	COG1802	Transcriptional regulator
D5285_01350	COG0730	response to heat
D5285_01370	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5285_01375	COG4682	membrane
D5285_01400	COG0697	spore germination
D5285_01405	COG2207	Transcriptional regulator
D5285_01405	COG1917	Cupin 2, conserved barrel domain protein
D5285_01415	COG2197	response regulator
D5285_01430	COG0371	Dehydrogenase
D5285_01445	COG4257	antibiotic catabolic process
D5285_01455	COG0833	amino acid
D5285_01460	COG2040	homocysteine
D5285_01470	COG1263	PTS System
D5285_01470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_01475	COG0789	Transcriptional regulator
D5285_01480	COG2323	membrane
D5285_01495	COG2205	protein histidine kinase activity
D5285_01500	COG1115	amino acid carrier protein
D5285_01505	COG2066	Belongs to the glutaminase family
D5285_01510	COG4191	Histidine kinase
D5285_01515	COG0784	Response regulator, receiver
D5285_01540	COG3540	Alkaline phosphatase
D5285_01545	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5285_01550	COG0805	protein transport
D5285_01555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5285_01560	COG1012	belongs to the aldehyde dehydrogenase family
D5285_01565	COG2271	Major facilitator Superfamily
D5285_01570	COG4948	Mandelate Racemase Muconate Lactonizing
D5285_01575	COG2186	Transcriptional regulator
D5285_01580	COG2721	sulfolactate sulfo-lyase activity
D5285_01600	COG0745	RESPONSE REGULATOR receiver
D5285_01605	COG2205	protein histidine kinase activity
D5285_01610	COG1131	(ABC) transporter
D5285_01635	COG3173	Aminoglycoside phosphotransferase
D5285_01640	COG1846	Transcriptional regulator
D5285_01645	COG0318	PFAM AMP-dependent synthetase and ligase
D5285_01665	COG0789	Transcriptional regulator
D5285_01690	COG0697	spore germination
D5285_01700	COG3012	SEC-C Motif Domain Protein
D5285_01700	COG1405	negative regulation of cell septum assembly
D5285_01730	COG0583	DNA-binding transcription factor activity
D5285_01735	COG1942	4-Oxalocrotonate Tautomerase
D5285_01740	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_01755	COG1288	antiporter activity
D5285_01765	COG0252	asparaginase activity
D5285_01770	COG0456	acetyltransferase
D5285_01780	COG1164	Oligoendopeptidase f
D5285_01785	COG2261	transglycosylase associated protein
D5285_01795	COG0247	lactate metabolic process
D5285_01800	COG0277	FAD linked oxidase domain protein
D5285_01805	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_01810	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5285_01815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_01820	COG1486	melibiose metabolic process
D5285_01830	COG3394	polysaccharide catabolic process
D5285_01845	COG3591	Belongs to the peptidase S1B family
D5285_01850	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_01860	COG1595	DNA-templated transcription, initiation
D5285_01870	COG3773	Cell wall hydrolase
D5285_01875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5285_01880	COG3883	PFAM NLP P60 protein
D5285_01880	COG0791	NLP P60 protein
D5285_01890	COG1131	(ABC) transporter
D5285_01895	COG1309	transcriptional regulator
D5285_01910	COG2310	stress, protein
D5285_01915	COG2310	stress, protein
D5285_01920	COG2310	stress, protein
D5285_01925	COG0861	Integral membrane protein TerC family
D5285_01945	COG3853	Toxic anion resistance protein (TelA)
D5285_01950	COG0785	Cytochrome C biogenesis protein
D5285_01960	COG2223	nitrite transmembrane transporter activity
D5285_01965	COG0039	L-malate dehydrogenase activity
D5285_01970	COG1620	l-lactate permease
D5285_01975	COG1280	lysine exporter protein (LysE YggA)
D5285_01980	COG1113	amino acid transport
D5285_01985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D5285_01990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D5285_01995	COG3541	Predicted nucleotidyltransferase
D5285_02000	COG0506	proline dehydrogenase activity
D5285_02005	COG1012	belongs to the aldehyde dehydrogenase family
D5285_02010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5285_02015	COG2508	Transcriptional regulator
D5285_02020	COG3689	TIGRFAM TIGR03943 family protein
D5285_02025	COG0701	Predicted permease
D5285_02030	COG3458	cephalosporin-C deacetylase activity
D5285_02050	COG0765	amino acid transport
D5285_02055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5285_02060	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5285_02065	COG1116	anion transmembrane transporter activity
D5285_02070	COG2723	6-phospho-beta-galactosidase activity
D5285_02080	COG3209	COG3209 Rhs family protein
D5285_02090	COG5444	nuclease activity
D5285_02115	COG1176	ABC-type spermidine putrescine transport system, permease component I
D5285_02120	COG1177	transmembrane transport
D5285_02130	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_02135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_02145	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D5285_02150	COG0697	spore germination
D5285_02155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5285_02165	COG2819	hydrolase of the alpha beta superfamily
D5285_02170	COG3708	Transcriptional regulator
D5285_02170	COG2207	Transcriptional regulator
D5285_02175	COG2364	Membrane
D5285_02205	COG1126	abc transporter atp-binding protein
D5285_02210	COG0765	amino acid transport
D5285_02215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5285_02220	COG3829	transcription factor binding
D5285_02225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5285_02230	COG0833	amino acid
D5285_02235	COG0010	Belongs to the arginase family
D5285_02240	COG0583	DNA-binding transcription factor activity
D5285_02245	COG0163	prenyltransferase activity
D5285_02250	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D5285_02340	COG2972	Histidine kinase
D5285_02345	COG2207	Transcriptional regulator
D5285_02345	COG4753	response regulator
D5285_02350	COG4213	ABC transporter substrate-binding protein
D5285_02360	COG4214	carbohydrate transport
D5285_02365	COG2271	Major facilitator Superfamily
D5285_02370	COG1846	Transcriptional regulator
D5285_02370	COG0456	acetyltransferase
D5285_02375	COG1874	Beta-galactosidase
D5285_02380	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D5285_02390	COG3104	oligopeptide transport
D5285_02395	COG5434	Belongs to the glycosyl hydrolase 28 family
D5285_02405	COG0697	spore germination
D5285_02415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D5285_02420	COG0789	Transcriptional regulator
D5285_02425	COG1136	(ABC) transporter
D5285_02430	COG0577	efflux transmembrane transporter activity
D5285_02435	COG0745	RESPONSE REGULATOR receiver
D5285_02440	COG3850	Histidine kinase
D5285_02440	COG5002	protein histidine kinase activity
D5285_02445	COG0840	transmembrane signaling receptor activity
D5285_02450	COG0527	aspartate kinase activity
D5285_02455	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_02460	COG4605	iron ion homeostasis
D5285_02465	COG4604	ABC transporter, ATP-binding protein
D5285_02470	COG4607	ABC-type enterochelin transport system periplasmic component
D5285_02475	COG2814	Major facilitator Superfamily
D5285_02480	COG1309	transcriptional regulator
D5285_02490	COG0778	Nitroreductase
D5285_02495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D5285_02500	COG0640	Transcriptional regulator
D5285_02505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5285_02510	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D5285_02515	COG0531	amino acid
D5285_02520	COG1012	belongs to the aldehyde dehydrogenase family
D5285_02525	COG0697	spore germination
D5285_02535	COG4549	nuclear export factor GLE1
D5285_02540	COG2372	response to copper ion
D5285_02540	COG1276	copper resistance
D5285_02545	COG1349	DNA-binding transcription factor activity
D5285_02550	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5285_02555	COG0243	molybdopterin cofactor binding
D5285_02560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5285_02565	COG2146	nitrite reductase [NAD(P)H] activity
D5285_02570	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5285_02570	COG1587	Uroporphyrinogen-III synthase
D5285_02575	COG1802	Transcriptional regulator
D5285_02580	COG0471	metal ion transport
D5285_02585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5285_02595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_02610	COG3959	Transketolase, thiamine diphosphate binding domain
D5285_02615	COG3958	Transketolase
D5285_02620	COG0561	phosphatase activity
D5285_02625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D5285_02630	COG1914	H( )-stimulated, divalent metal cation uptake system
D5285_02635	COG4336	lyase activity
D5285_02640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D5285_02645	COG1984	allophanate hydrolase subunit 2
D5285_02650	COG1414	Transcriptional regulator
D5285_02655	COG2755	lipolytic protein G-D-S-L family
D5285_02665	COG2213	PTS system mannitol-specific
D5285_02670	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_02675	COG0246	Mannitol dehydrogenase
D5285_02685	COG3711	transcriptional antiterminator
D5285_02690	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_02695	COG1917	Cupin 2, conserved barrel domain protein
D5285_02705	COG3871	stress protein (general stress protein 26)
D5285_02715	COG1316	TRANSCRIPTIONal
D5285_02720	COG2814	Major facilitator Superfamily
D5285_02730	COG1522	sequence-specific DNA binding
D5285_02735	COG0551	DNA topoisomerase type I activity
D5285_02735	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5285_02740	COG0287	Prephenate dehydrogenase
D5285_02745	COG0512	Glutamine amidotransferase of anthranilate synthase
D5285_02745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5285_02750	COG1605	Chorismate mutase
D5285_02760	COG0028	Belongs to the TPP enzyme family
D5285_02765	COG3397	chitin binding
D5285_02775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5285_02780	COG1914	H( )-stimulated, divalent metal cation uptake system
D5285_02785	COG2261	transglycosylase associated protein
D5285_02790	COG1027	Aspartate ammonia-lyase
D5285_02795	COG1819	glycosyl
D5285_02800	COG4876	unkown
D5285_02805	COG2217	Heavy metal translocating P-type atpase
D5285_02815	COG0662	Cupin 2, conserved barrel domain protein
D5285_02825	COG0628	permease
D5285_02830	COG1301	dicarboxylic acid transport
D5285_02835	COG1131	(ABC) transporter
D5285_02840	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D5285_02850	COG1960	acyl-CoA dehydrogenase activity
D5285_02865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_02870	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5285_02875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D5285_02885	COG0513	Belongs to the DEAD box helicase family
D5285_02890	COG3402	PFAM membrane-flanked domain
D5285_02895	COG3428	Bacterial PH domain
D5285_02900	COG0705	Rhomboid family
D5285_02905	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D5285_02910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5285_02915	COG0864	Transcriptional regulator
D5285_02920	COG2337	Toxic component of a toxin-antitoxin (TA) module
D5285_02925	COG1366	Belongs to the anti-sigma-factor antagonist family
D5285_02930	COG1366	Belongs to the anti-sigma-factor antagonist family
D5285_02935	COG2172	sigma factor antagonist activity
D5285_02940	COG2208	phosphoserine phosphatase activity
D5285_02955	COG1191	sigma factor activity
D5285_02960	COG2208	phosphoserine phosphatase activity
D5285_02965	COG2183	response to ionizing radiation
D5285_02970	COG1309	transcriptional regulator
D5285_02980	COG2409	Drug exporters of the RND superfamily
D5285_02980	COG1033	growth of symbiont in host cell
D5285_02990	COG3091	SprT-like family
D5285_03030	COG0726	polysaccharide deacetylase
D5285_03040	COG1476	TRANSCRIPTIONal
D5285_03045	COG3239	Fatty acid desaturase
D5285_03050	COG1278	Cold shock
D5285_03085	COG2364	Membrane
D5285_03090	COG1846	Transcriptional regulator
D5285_03095	COG0456	acetyltransferase
D5285_03100	COG2808	Putative FMN-binding domain
D5285_03110	COG1733	regulation of RNA biosynthetic process
D5285_03115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_03145	COG3545	Serine hydrolase
D5285_03150	COG1733	regulation of RNA biosynthetic process
D5285_03165	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D5285_03170	COG1113	amino acid transport
D5285_03185	COG0596	Alpha beta hydrolase
D5285_03190	COG5566	PFAM Mor transcription activator
D5285_03195	COG1595	DNA-templated transcription, initiation
D5285_03205	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D5285_03205	COG2755	lipolytic protein G-D-S-L family
D5285_03210	COG0494	nUDIX hydrolase
D5285_03215	COG2814	Major facilitator Superfamily
D5285_03220	COG1979	alcohol dehydrogenase
D5285_03225	COG0745	RESPONSE REGULATOR receiver
D5285_03225	COG2972	Histidine kinase
D5285_03230	COG3279	Response regulator of the LytR AlgR family
D5285_03240	COG3764	Sortase (surface protein transpeptidase)
D5285_03250	COG2814	Major facilitator Superfamily
D5285_03290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D5285_03295	COG0802	atpase or kinase
D5285_03300	COG1214	PFAM Peptidase M22, glycoprotease
D5285_03305	COG0456	acetyltransferase
D5285_03310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D5285_03315	COG0488	(ABC) transporter
D5285_03320	COG0315	cyclic pyranopterin monophosphate synthase activity
D5285_03325	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D5285_03330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D5285_03335	COG0805	protein transport
D5285_03345	COG1266	CAAX protease self-immunity
D5285_03350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D5285_03355	COG0459	protein refolding
D5285_03360	COG4974	Belongs to the 'phage' integrase family
D5285_03365	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5285_03460	COG0582	viral genome integration into host DNA
D5285_03545	COG3953	SLT domain
D5285_03545	COG5280	Phage tail tape measure protein TP901
D5285_03605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5285_03620	COG2720	vancomycin resistance protein
D5285_03640	COG2135	peptidase activity
D5285_03650	COG1309	transcriptional regulator
D5285_03655	COG3848	Pyruvate phosphate dikinase
D5285_03655	COG0574	Belongs to the PEP-utilizing enzyme family
D5285_03670	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D5285_03675	COG2272	Belongs to the type-B carboxylesterase lipase family
D5285_03680	COG2814	Major facilitator Superfamily
D5285_03685	COG1842	Phage shock protein A
D5285_03690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5285_03695	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D5285_03700	COG4260	virion core protein, lumpy skin disease virus
D5285_03710	COG1378	Sugar-specific transcriptional regulator TrmB
D5285_03715	COG1280	lysine exporter protein (LysE YggA)
D5285_03720	COG3339	Conserved Protein
D5285_03725	COG0772	Belongs to the SEDS family
D5285_03730	COG0772	Belongs to the SEDS family
D5285_03750	COG0726	polysaccharide deacetylase
D5285_03760	COG1609	Transcriptional regulator
D5285_03765	COG0366	Alpha amylase catalytic
D5285_03770	COG2182	Extracellular solute-binding protein
D5285_03775	COG1175	transmembrane transport
D5285_03780	COG3833	ABC-type maltose transport systems, permease component
D5285_03785	COG5521	maltodextrose utilization protein MalA
D5285_03790	COG1554	hydrolase, family 65, central catalytic
D5285_03795	COG0366	Alpha amylase catalytic
D5285_03800	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5285_03805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5285_03810	COG1846	Transcriptional regulator
D5285_03825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D5285_03830	COG0823	Involved in the tonB-independent uptake of proteins
D5285_03860	COG0702	epimerase
D5285_03870	COG2132	Multicopper oxidase
D5285_03890	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D5285_03895	COG0714	Associated with various cellular activities
D5285_03900	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D5285_03905	COG1305	Transglutaminase-like
D5285_03910	COG0519	Catalyzes the synthesis of GMP from XMP
D5285_03910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D5285_03920	COG2252	PERMEase
D5285_03935	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D5285_03945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D5285_03950	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D5285_03955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D5285_03960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D5285_03965	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5285_03970	COG0047	phosphoribosylformylglycinamidine synthase activity
D5285_03975	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D5285_03980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D5285_03985	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D5285_03990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D5285_03995	COG0138	bifunctional purine biosynthesis protein purh
D5285_04000	COG0151	Belongs to the GarS family
D5285_04010	COG2124	cytochrome p450
D5285_04035	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5285_04040	COG1470	cell adhesion involved in biofilm formation
D5285_04045	COG4496	protein, YerC YecD
D5285_04050	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D5285_04055	COG0210	DNA helicase
D5285_04060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D5285_04065	COG4851	CamS sex pheromone cAM373 precursor
D5285_04070	COG2188	Transcriptional regulator
D5285_04090	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D5285_04095	COG0626	cystathionine gamma-synthase activity
D5285_04100	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5285_04105	COG3457	Alanine racemase
D5285_04110	COG0363	glucosamine-6-phosphate deaminase activity
D5285_04115	COG1285	pathogenesis
D5285_04120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5285_04125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5285_04130	COG0154	amidase activity
D5285_04135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D5285_04150	COG4124	Belongs to the glycosyl hydrolase 26 family
D5285_04155	COG1309	transcriptional regulator
D5285_04160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D5285_04170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5285_04175	COG1957	nucleoside hydrolase
D5285_04180	COG1597	lipid kinase activity
D5285_04185	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5285_04220	COG3711	transcriptional antiterminator
D5285_04225	COG0457	Tetratricopeptide repeat
D5285_04240	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D5285_04240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5285_04245	COG3586	endonuclease activity
D5285_04250	COG0697	spore germination
D5285_04255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5285_04260	COG0697	spore germination
D5285_04265	COG0217	transcriptional regulatory protein
D5285_04295	COG1012	belongs to the aldehyde dehydrogenase family
D5285_04300	COG0840	transmembrane signaling receptor activity
D5285_04305	COG0109	protoheme IX farnesyltransferase activity
D5285_04310	COG1309	transcriptional regulator
D5285_04315	COG0471	metal ion transport
D5285_04320	COG0488	(ABC) transporter
D5285_04325	COG0583	DNA-binding transcription factor activity
D5285_04335	COG0640	Transcriptional regulator
D5285_04340	COG1469	GTP cyclohydrolase I activity
D5285_04355	COG0523	cobalamin synthesis protein
D5285_04360	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
D5285_04365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5285_04370	COG0156	8-amino-7-oxononanoate synthase activity
D5285_04375	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D5285_04380	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D5285_04385	COG2124	cytochrome p450
D5285_04395	COG0789	Transcriptional regulator
D5285_04400	COG2814	Major facilitator Superfamily
D5285_04410	COG0488	(ABC) transporter
D5285_04415	COG0513	Belongs to the DEAD box helicase family
D5285_04420	COG2130	NADP-dependent
D5285_04435	COG0471	metal ion transport
D5285_04465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5285_04475	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D5285_04480	COG3858	chitin binding
D5285_04485	COG5658	integral membrane protein
D5285_04490	COG0640	Transcriptional regulator
D5285_04495	COG1254	Belongs to the acylphosphatase family
D5285_04500	COG2258	MOSC domain
D5285_04510	COG0024	Methionine aminopeptidase
D5285_04515	COG1368	sulfuric ester hydrolase activity
D5285_04525	COG1115	amino acid carrier protein
D5285_04530	COG1263	PTS System
D5285_04530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_04535	COG0366	Alpha amylase catalytic
D5285_04540	COG2188	Transcriptional regulator
D5285_04565	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5285_04570	COG1045	serine acetyltransferase
D5285_04575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5285_04585	COG1215	transferase activity, transferring glycosyl groups
D5285_04590	COG0457	Tetratricopeptide repeat
D5285_04590	COG0463	Glycosyl transferase, family 2
D5285_04600	COG0673	inositol 2-dehydrogenase activity
D5285_04615	COG1733	regulation of RNA biosynthetic process
D5285_04620	COG0778	Nitroreductase
D5285_04625	COG0737	Belongs to the 5'-nucleotidase family
D5285_04630	COG0693	protein deglycase activity
D5285_04635	COG4840	Belongs to the UPF0435 family
D5285_04640	COG1115	amino acid carrier protein
D5285_04645	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5285_04650	COG4980	gas vesicle protein
D5285_04655	COG1295	ribonuclease BN
D5285_04660	COG0477	Major facilitator Superfamily
D5285_04670	COG0387	Pfam Sodium calcium exchanger
D5285_04680	COG0535	radical SAM domain protein
D5285_04690	COG0726	polysaccharide deacetylase
D5285_04695	COG0371	Dehydrogenase
D5285_04705	COG0598	Magnesium transport protein CorA
D5285_04710	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D5285_04715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D5285_04720	COG4637	Psort location Cytoplasmic, score
D5285_04745	COG1819	glycosyl
D5285_04755	COG0477	Major facilitator Superfamily
D5285_04765	COG1263	PTS System
D5285_04765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_04770	COG3711	transcriptional antiterminator
D5285_04775	COG0288	reversible hydration of carbon dioxide
D5285_04780	COG3002	Belongs to the UPF0753 family
D5285_04785	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5285_04790	COG5609	conserved protein (DUF2294)
D5285_04800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5285_04805	COG0022	dehydrogenase e1 component
D5285_04810	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5285_04815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5285_04820	COG3284	Transcriptional regulator
D5285_04825	COG1742	UPF0060 membrane protein
D5285_04830	COG1486	melibiose metabolic process
D5285_04835	COG1737	Transcriptional regulator
D5285_04840	COG1263	PTS System
D5285_04840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_04855	COG1733	regulation of RNA biosynthetic process
D5285_04860	COG2259	Doxx family
D5285_04865	COG2514	catechol 2,3-dioxygenase activity
D5285_04875	COG3507	Belongs to the glycosyl hydrolase 43 family
D5285_04885	COG1653	transport
D5285_04890	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5285_04895	COG1051	belongs to the nudix hydrolase family
D5285_04905	COG0392	lysyltransferase activity
D5285_04905	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D5285_04910	COG0384	phenazine biosynthesis protein PhzF
D5285_04915	COG0778	Nitroreductase
D5285_04935	COG1090	epimerase
D5285_04940	COG2137	regulation of response to DNA damage stimulus
D5285_04965	COG0463	Glycosyl transferase, family 2
D5285_04975	COG4485	Bacterial membrane protein, YfhO
D5285_04980	COG1988	membrane-bound metal-dependent
D5285_04985	COG1194	a g-specific adenine glycosylase
D5285_04995	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_05010	COG3557	Belongs to the UPF0374 family
D5285_05015	COG1132	(ABC) transporter
D5285_05020	COG0444	Belongs to the ABC transporter superfamily
D5285_05025	COG4608	Belongs to the ABC transporter superfamily
D5285_05030	COG0747	negative chemotaxis
D5285_05050	COG4129	membrane
D5285_05055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5285_05065	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D5285_05070	COG0735	belongs to the Fur family
D5285_05185	COG0457	Tetratricopeptide repeat
D5285_05225	COG0732	type I restriction modification DNA specificity domain
D5285_05230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5285_05250	COG0710	3-dehydroquinate dehydratase activity
D5285_05255	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D5285_05260	COG1116	anion transmembrane transporter activity
D5285_05265	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5285_05270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5285_05275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5285_05285	COG1476	TRANSCRIPTIONal
D5285_05295	COG1131	(ABC) transporter
D5285_05315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5285_05325	COG3382	B3 4 domain protein
D5285_05330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D5285_05340	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D5285_05345	COG0789	Transcriptional regulator
D5285_05350	COG1664	Polymer-forming cytoskeletal
D5285_05355	COG1664	Polymer-forming cytoskeletal
D5285_05360	COG2766	serine protein kinase
D5285_05365	COG2718	Belongs to the UPF0229 family
D5285_05370	COG1566	PFAM secretion protein HlyD family protein
D5285_05375	COG2814	Major facilitator Superfamily
D5285_05380	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5285_05390	COG1131	(ABC) transporter
D5285_05395	COG1131	(ABC) transporter
D5285_05400	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D5285_05405	COG1278	Cold shock
D5285_05410	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5285_05415	COG2011	ABC-type metal ion transport system permease component
D5285_05420	COG1464	Belongs to the NlpA lipoprotein family
D5285_05425	COG1823	symporter activity
D5285_05450	COG5577	PFAM Coat F domain
D5285_05460	COG5002	protein histidine kinase activity
D5285_05465	COG0737	Belongs to the 5'-nucleotidase family
D5285_05465	COG1525	nuclease
D5285_05465	COG4085	toxin activity
D5285_05470	COG3764	Sortase (surface protein transpeptidase)
D5285_05475	COG0564	pseudouridine synthase activity
D5285_05485	COG0517	IMP dehydrogenase activity
D5285_05490	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D5285_05495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5285_05495	COG3153	acetyltransferase
D5285_05500	COG0488	(ABC) transporter
D5285_05505	COG2116	formate transmembrane transporter activity
D5285_05520	COG0604	alcohol dehydrogenase
D5285_05525	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D5285_05530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D5285_05535	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D5285_05540	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D5285_05545	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D5285_05560	COG4585	Histidine kinase
D5285_05560	COG2203	Gaf domain
D5285_05565	COG2197	response regulator
D5285_05570	COG0431	NADPH-dependent FMN reductase
D5285_05585	COG1959	2 iron, 2 sulfur cluster binding
D5285_05590	COG1017	nitric oxide dioxygenase activity
D5285_05590	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D5285_05595	COG2719	SpoVR family
D5285_05600	COG0791	NLP P60 protein
D5285_05600	COG1388	LysM domain
D5285_05605	COG0583	DNA-binding transcription factor activity
D5285_05610	COG0372	Belongs to the citrate synthase family
D5285_05620	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_05625	COG0733	neurotransmitter:sodium symporter activity
D5285_05655	COG2207	Transcriptional regulator
D5285_05655	COG3708	Transcriptional regulator
D5285_05660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5285_05680	COG1595	DNA-templated transcription, initiation
D5285_05685	COG0662	Cupin 2, conserved barrel domain protein
D5285_05690	COG0667	Aldo Keto reductase
D5285_05695	COG0204	Acyl-transferase
D5285_05700	COG3152	Membrane
D5285_05710	COG1309	transcriptional regulator
D5285_05715	COG1253	flavin adenine dinucleotide binding
D5285_05720	COG0789	Transcriptional regulator
D5285_05725	COG1253	flavin adenine dinucleotide binding
D5285_05745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5285_05750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D5285_05755	COG0584	glycerophosphoryl diester phosphodiesterase
D5285_05765	COG0668	transmembrane transport
D5285_05770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D5285_05780	COG0726	polysaccharide deacetylase
D5285_05790	COG1757	Na H antiporter
D5285_05795	COG2017	converts alpha-aldose to the beta-anomer
D5285_05820	COG0589	response to stress
D5285_05825	COG1132	(ABC) transporter
D5285_05830	COG1132	(ABC) transporter
D5285_05835	COG0702	epimerase
D5285_05850	COG3842	ATPase activity
D5285_05855	COG2508	Transcriptional regulator
D5285_05865	COG0189	ligase activity
D5285_05870	COG0189	ligase activity
D5285_05875	COG4399	Belongs to the UPF0754 family
D5285_05880	COG3679	Belongs to the UPF0342 family
D5285_05890	COG0561	phosphatase activity
D5285_05895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5285_05900	COG0475	glutathione-regulated potassium exporter activity
D5285_05905	COG0490	domain, Protein
D5285_05915	COG1024	Enoyl-CoA hydratase
D5285_05920	COG0457	Tetratricopeptide repeat
D5285_05935	COG4152	abc transporter atp-binding protein
D5285_05940	COG1668	transmembrane transport
D5285_05945	COG0420	3'-5' exonuclease activity
D5285_05950	COG4717	serine-type aminopeptidase activity
D5285_05955	COG3481	metal-dependent phosphohydrolase, HD sub domain
D5285_05965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D5285_05995	COG1846	Transcriptional regulator
D5285_06000	COG4980	gas vesicle protein
D5285_06015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D5285_06020	COG0537	adenosine 5'-monophosphoramidase activity
D5285_06030	COG1131	(ABC) transporter
D5285_06035	COG4473	ABC transporter
D5285_06045	COG1473	amidohydrolase
D5285_06050	COG3069	C4-dicarboxylate transmembrane transporter activity
D5285_06055	COG2329	Antibiotic biosynthesis monooxygenase
D5285_06060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5285_06065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D5285_06080	COG1309	transcriptional regulator
D5285_06085	COG1511	domain protein
D5285_06090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5285_06095	COG1363	Peptidase, m42
D5285_06105	COG1301	dicarboxylic acid transport
D5285_06115	COG1234	tRNA 3'-trailer cleavage
D5285_06120	COG0095	Lipoate-protein ligase
D5285_06125	COG0318	PFAM AMP-dependent synthetase and ligase
D5285_06135	COG1396	sequence-specific DNA binding
D5285_06150	COG0501	Belongs to the peptidase M48B family
D5285_06160	COG0697	spore germination
D5285_06165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D5285_06175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_06180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_06185	COG0406	alpha-ribazole phosphatase activity
D5285_06190	COG0840	transmembrane signaling receptor activity
D5285_06195	COG0723	plastoquinol--plastocyanin reductase activity
D5285_06195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5285_06200	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_06210	COG4903	ComK protein
D5285_06220	COG0398	Pfam SNARE associated Golgi protein
D5285_06225	COG0681	Belongs to the peptidase S26 family
D5285_06235	COG1404	Belongs to the peptidase S8 family
D5285_06245	COG2508	Transcriptional regulator
D5285_06250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D5285_06255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5285_06260	COG3257	ureidoglycine aminohydrolase activity
D5285_06265	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D5285_06270	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D5285_06275	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5285_06280	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5285_06290	COG0549	Belongs to the carbamate kinase family
D5285_06305	COG0457	Tetratricopeptide repeat
D5285_06335	COG1486	melibiose metabolic process
D5285_06340	COG3180	Ammonia monooxygenase
D5285_06355	COG3546	catalase activity
D5285_06360	COG0318	PFAM AMP-dependent synthetase and ligase
D5285_06365	COG0477	Major facilitator Superfamily
D5285_06365	COG2814	Major facilitator Superfamily
D5285_06370	COG4533	DNA binding
D5285_06380	COG5002	protein histidine kinase activity
D5285_06385	COG0745	RESPONSE REGULATOR receiver
D5285_06395	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D5285_06400	COG0725	ABC transporter, periplasmic molybdate-binding protein
D5285_06405	COG4149	molybdate abc transporter
D5285_06410	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D5285_06415	COG1074	ATP-dependent DNA helicase activity
D5285_06420	COG0420	3'-5' exonuclease activity
D5285_06425	COG0419	ATPase involved in DNA repair
D5285_06470	COG5337	Spore coat protein CotH
D5285_06480	COG0179	Fumarylacetoacetate (FAA) hydrolase
D5285_06505	COG0367	asparagine synthase
D5285_06510	COG0004	ammonium transporteR
D5285_06515	COG0347	Belongs to the P(II) protein family
D5285_06520	COG0534	Mate efflux family protein
D5285_06525	COG1917	Cupin 2, conserved barrel domain protein
D5285_06525	COG2207	Transcriptional regulator
D5285_06535	COG1609	Transcriptional regulator
D5285_06540	COG0673	inositol 2-dehydrogenase activity
D5285_06555	COG0697	spore germination
D5285_06560	COG1279	arginine transmembrane transporter activity
D5285_06565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5285_06575	COG0076	glutamate decarboxylase activity
D5285_06600	COG2153	protein acetylation
D5285_06605	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_06610	COG2378	regulation of single-species biofilm formation
D5285_06615	COG1410	methionine synthase
D5285_06615	COG0646	methionine synthase
D5285_06620	COG0646	methionine synthase
D5285_06620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D5285_06625	COG1666	GTP binding
D5285_06630	COG2996	Protein conserved in bacteria
D5285_06645	COG1307	EDD domain protein, DegV family
D5285_06650	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_06660	COG0516	GMP reductase activity
D5285_06670	COG0561	phosphatase activity
D5285_06675	COG1073	alpha beta
D5285_06680	COG2151	metal-sulfur cluster biosynthetic enzyme
D5285_06690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D5285_06695	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D5285_06700	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D5285_06705	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D5285_06710	COG0505	Belongs to the CarA family
D5285_06715	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5285_06720	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5285_06725	COG1968	undecaprenyl-diphosphatase activity
D5285_06740	COG2267	carboxylic ester hydrolase activity
D5285_06750	COG1744	ABC transporter substrate-binding protein PnrA-like
D5285_06765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5285_06770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D5285_06775	COG5504	Zn-dependent protease
D5285_06780	COG0444	Belongs to the ABC transporter superfamily
D5285_06785	COG4608	Belongs to the ABC transporter superfamily
D5285_06795	COG0601	transmembrane transport
D5285_06800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5285_06815	COG0180	Tryptophanyl-tRNA synthetase
D5285_06825	COG4166	transmembrane transport
D5285_06830	COG0601	transmembrane transport
D5285_06835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5285_06840	COG0444	Belongs to the ABC transporter superfamily
D5285_06845	COG4608	Belongs to the ABC transporter superfamily
D5285_06850	COG0456	acetyltransferase
D5285_06855	COG1393	Belongs to the ArsC family
D5285_06860	COG0861	Integral membrane protein TerC family
D5285_06870	COG4862	establishment of competence for transformation
D5285_06895	COG4565	transcriptional regulatory protein
D5285_06900	COG3290	protein histidine kinase activity
D5285_06905	COG4469	Competence protein
D5285_06910	COG1164	Oligoendopeptidase f
D5285_06925	COG2346	COG2346, Truncated hemoglobins
D5285_06930	COG0741	lytic transglycosylase activity
D5285_06935	COG4116	CYTH
D5285_06945	COG2357	RelA SpoT domain protein
D5285_06950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5285_06955	COG0564	pseudouridine synthase activity
D5285_06960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D5285_06965	COG0475	glutathione-regulated potassium exporter activity
D5285_06965	COG0569	domain protein
D5285_06970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D5285_06975	COG0352	thiamine-phosphate diphosphorylase activity
D5285_06985	COG2104	thiamine diphosphate biosynthetic process
D5285_06990	COG2022	thiamine diphosphate biosynthetic process
D5285_06995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5285_07000	COG0351	phosphomethylpyrimidine kinase
D5285_07005	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D5285_07060	COG0210	DNA helicase
D5285_07070	COG0586	Pfam SNARE associated Golgi protein
D5285_07075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5285_07080	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5285_07085	COG2246	polysaccharide biosynthetic process
D5285_07090	COG2153	protein acetylation
D5285_07095	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5285_07100	COG2382	esterase
D5285_07120	COG0626	cystathionine gamma-synthase activity
D5285_07125	COG0626	cystathionine gamma-synthase activity
D5285_07130	COG5505	Protein of unknown function (DUF819)
D5285_07145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5285_07155	COG3507	Belongs to the glycosyl hydrolase 43 family
D5285_07230	COG0110	maltose O-acetyltransferase activity
D5285_07240	COG0583	DNA-binding transcription factor activity
D5285_07245	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5285_07250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D5285_07255	COG0583	DNA-binding transcription factor activity
D5285_07260	COG0697	spore germination
D5285_07265	COG0346	lactoylglutathione lyase activity
D5285_07275	COG3584	3D domain protein
D5285_07275	COG1388	LysM domain
D5285_07280	COG2814	Major facilitator Superfamily
D5285_07285	COG1309	transcriptional regulator
D5285_07300	COG4195	phage-related replication protein
D5285_07305	COG2856	Zn peptidase
D5285_07310	COG1396	sequence-specific DNA binding
D5285_07325	COG1522	sequence-specific DNA binding
D5285_07330	COG1484	DNA-dependent DNA replication
D5285_07345	COG1595	DNA-templated transcription, initiation
D5285_07350	COG3728	DNA packaging
D5285_07350	COG5484	DNA packaging
D5285_07355	COG1783	phage Terminase large subunit
D5285_07360	COG5518	Phage portal protein
D5285_07365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D5285_07370	COG4653	Phage capsid family
D5285_07420	COG5280	Phage tail tape measure protein TP901
D5285_07420	COG3953	SLT domain
D5285_07425	COG1652	LysM domain
D5285_07430	COG4193	domain, Protein
D5285_07440	COG3628	GPW Gp25 family protein
D5285_07445	COG3299	homolog of phage Mu protein gp47
D5285_07450	COG3778	Protein conserved in bacteria
D5285_07475	COG3594	Acyltransferase
D5285_07485	COG1802	Transcriptional regulator
D5285_07490	COG1063	alcohol dehydrogenase
D5285_07495	COG1312	Catalyzes the dehydration of D-mannonate
D5285_07500	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_07505	COG1063	alcohol dehydrogenase
D5285_07510	COG2271	Major facilitator Superfamily
D5285_07525	COG0306	phosphate transporter
D5285_07530	COG1392	Phosphate transport regulator
D5285_07535	COG0405	Gamma-glutamyltransferase
D5285_07540	COG5578	integral membrane protein
D5285_07545	COG2972	Histidine kinase
D5285_07550	COG2207	Transcriptional regulator
D5285_07550	COG4753	response regulator
D5285_07555	COG1653	transport
D5285_07560	COG1175	transmembrane transport
D5285_07565	COG0395	ABC-type sugar transport system, permease component
D5285_07570	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5285_07575	COG2207	Transcriptional regulator
D5285_07580	COG2755	lipolytic protein G-D-S-L family
D5285_07590	COG5578	integral membrane protein
D5285_07595	COG3401	FG-GAP repeat protein
D5285_07605	COG2755	lipolytic protein G-D-S-L family
D5285_07610	COG3401	FG-GAP repeat protein
D5285_07615	COG0667	Aldo Keto reductase
D5285_07620	COG2755	lipolytic protein G-D-S-L family
D5285_07625	COG1874	Beta-galactosidase
D5285_07635	COG1653	transport
D5285_07640	COG4209	transmembrane transport
D5285_07645	COG0395	ABC-type sugar transport system, permease component
D5285_07650	COG0531	amino acid
D5285_07655	COG0346	lactoylglutathione lyase activity
D5285_07660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5285_07665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5285_07675	COG2362	D-Aminopeptidase
D5285_07680	COG0601	transmembrane transport
D5285_07685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5285_07690	COG0444	Belongs to the ABC transporter superfamily
D5285_07695	COG4166	transmembrane transport
D5285_07700	COG1619	proteins homologs of microcin C7 resistance protein MccF
D5285_07705	COG4948	Mandelate Racemase Muconate Lactonizing
D5285_07710	COG0791	NLP P60 protein
D5285_07715	COG4608	Belongs to the ABC transporter superfamily
D5285_07725	COG1834	amidinotransferase
D5285_07730	COG1607	acyl-coa hydrolase
D5285_07735	COG2323	membrane
D5285_07740	COG3866	Pectate lyase
D5285_07760	COG2318	DinB family
D5285_07765	COG2076	Multidrug Resistance protein
D5285_07770	COG2076	Multidrug Resistance protein
D5285_07775	COG0788	formyltetrahydrofolate deformylase activity
D5285_07785	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5285_07790	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5285_07795	COG1764	response to oxidative stress
D5285_07800	COG1846	Transcriptional regulator
D5285_07805	COG1764	response to oxidative stress
D5285_07815	COG0590	tRNA wobble adenosine to inosine editing
D5285_07820	COG0406	alpha-ribazole phosphatase activity
D5285_07835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5285_07840	COG1404	Belongs to the peptidase S8 family
D5285_07850	COG2239	Acts as a magnesium transporter
D5285_07860	COG0789	Transcriptional regulator
D5285_07875	COG1846	Transcriptional regulator
D5285_07880	COG3285	dna ligase
D5285_07880	COG1793	dna ligase
D5285_07885	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D5285_07890	COG3300	MHYT domain
D5285_07890	COG5001	Diguanylate cyclase
D5285_07895	COG0586	Pfam SNARE associated Golgi protein
D5285_07900	COG0861	Integral membrane protein TerC family
D5285_07905	COG1191	sigma factor activity
D5285_07925	COG0501	Belongs to the peptidase M48B family
D5285_07930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5285_07935	COG0768	penicillin binding
D5285_07950	COG3594	Acyltransferase
D5285_07955	COG5002	protein histidine kinase activity
D5285_07960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5285_07965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D5285_07970	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D5285_07975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D5285_07980	COG0436	Aminotransferase
D5285_07985	COG1850	ribulose-bisphosphate carboxylase activity
D5285_07990	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D5285_07990	COG0235	Class ii aldolase
D5285_07995	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D5285_07995	COG0235	Class ii aldolase
D5285_08000	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D5285_08005	COG0346	lactoylglutathione lyase activity
D5285_08010	COG3339	Conserved Protein
D5285_08020	COG3852	Histidine kinase
D5285_08025	COG1846	Transcriptional regulator
D5285_08030	COG1360	Flagellar Motor Protein
D5285_08035	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5285_08040	COG0542	response to heat
D5285_08045	COG3949	Membrane
D5285_08050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D5285_08055	COG0720	synthase
D5285_08060	COG0602	queuosine metabolic process
D5285_08065	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D5285_08075	COG0457	Tetratricopeptide repeat
D5285_08080	COG3739	integral membrane protein
D5285_08085	COG3655	Transcriptional regulator
D5285_08120	COG4873	Protein conserved in bacteria
D5285_08130	COG3773	Cell wall hydrolase
D5285_08135	COG2244	polysaccharide biosynthetic process
D5285_08140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_08145	COG2217	Heavy metal translocating P-type atpase
D5285_08150	COG0006	proline dipeptidase activity
D5285_08160	COG1609	Transcriptional regulator
D5285_08165	COG3711	transcriptional antiterminator
D5285_08170	COG1263	PTS System
D5285_08170	COG2190	(PTS) system
D5285_08170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_08175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_08180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D5285_08190	COG1533	DNA photolyase activity
D5285_08195	COG0456	acetyltransferase
D5285_08200	COG0840	transmembrane signaling receptor activity
D5285_08205	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_08210	COG2084	Dehydrogenase
D5285_08215	COG2340	Cysteine-rich secretory protein family
D5285_08220	COG0768	penicillin binding
D5285_08225	COG4191	Histidine kinase
D5285_08230	COG0436	Aminotransferase
D5285_08235	COG1714	RDD family
D5285_08245	COG0835	chemotaxis
D5285_08245	COG0784	Response regulator, receiver
D5285_08255	COG2814	Major facilitator Superfamily
D5285_08260	COG1376	ErfK ybiS ycfS ynhG family protein
D5285_08265	COG1408	metallophosphoesterase
D5285_08270	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_08275	COG2200	EAL domain
D5285_08290	COG4703	Protein of unknown function (DUF1797)
D5285_08295	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D5285_08305	COG0517	IMP dehydrogenase activity
D5285_08310	COG0583	DNA-binding transcription factor activity
D5285_08315	COG0716	FMN binding
D5285_08325	COG0716	FMN binding
D5285_08330	COG2171	N-acyltransferase activity
D5285_08335	COG1473	amidohydrolase
D5285_08345	COG0450	alkyl hydroperoxide reductase
D5285_08350	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_08365	COG0746	molybdenum cofactor guanylyltransferase activity
D5285_08370	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D5285_08375	COG0303	'Molybdopterin
D5285_08380	COG1763	Mo-molybdopterin cofactor biosynthetic process
D5285_08385	COG0314	molybdopterin synthase activity
D5285_08390	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D5285_08400	COG1132	(ABC) transporter
D5285_08405	COG1132	(ABC) transporter
D5285_08415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D5285_08420	COG1136	(ABC) transporter
D5285_08425	COG0577	efflux transmembrane transporter activity
D5285_08435	COG1349	DNA-binding transcription factor activity
D5285_08440	COG1105	Belongs to the carbohydrate kinase PfkB family
D5285_08445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_08445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5285_08445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5285_08465	COG0488	(ABC) transporter
D5285_08475	COG2309	aminopeptidase activity
D5285_08485	COG1077	Cell shape determining protein MreB Mrl
D5285_08490	COG2002	toxin-antitoxin pair type II binding
D5285_08495	COG3852	Histidine kinase
D5285_08500	COG0569	domain protein
D5285_08505	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D5285_08510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D5285_08525	COG0561	phosphatase activity
D5285_08530	COG0242	peptide deformylase activity
D5285_08540	COG0497	DNA recombination
D5285_08545	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5285_08550	COG0022	dehydrogenase e1 component
D5285_08555	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5285_08560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5285_08565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_08575	COG1982	Orn Lys Arg decarboxylase major
D5285_08585	COG4476	Belongs to the UPF0223 family
D5285_08590	COG4493	Belongs to the UPF0637 family
D5285_08600	COG0483	inositol monophosphate 1-phosphatase activity
D5285_08620	COG1595	DNA-templated transcription, initiation
D5285_08645	COG1846	Transcriptional regulator
D5285_08650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D5285_08655	COG4896	Protein conserved in bacteria
D5285_08665	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D5285_08670	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5285_08675	COG2066	Belongs to the glutaminase family
D5285_08680	COG4838	Belongs to the UPF0358 family
D5285_08685	COG0772	Belongs to the SEDS family
D5285_08690	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D5285_08695	COG1612	heme a metabolic process
D5285_08700	COG0109	protoheme IX farnesyltransferase activity
D5285_08705	COG2010	Cytochrome c
D5285_08705	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5285_08710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5285_08715	COG1845	cytochrome c oxidase, subunit III
D5285_08720	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D5285_08725	COG3336	cytochrome c oxidase
D5285_08740	COG2340	Cysteine-rich secretory protein family
D5285_08755	COG3679	Belongs to the UPF0342 family
D5285_08760	COG4471	UPF0298 protein
D5285_08765	COG0742	ribosomal rna small subunit methyltransferase
D5285_08770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D5285_08775	COG3314	Sporulation integral membrane protein YlbJ
D5285_08780	COG3480	Lon protease (S16) C-terminal proteolytic domain
D5285_08785	COG1323	Belongs to the UPF0348 family
D5285_08790	COG1399	metal-binding, possibly nucleic acid-binding protein
D5285_08795	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D5285_08805	COG0454	-acetyltransferase
D5285_08810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D5285_08815	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D5285_08820	COG2001	Belongs to the MraZ family
D5285_08825	COG0275	rRNA processing
D5285_08830	COG4839	cell division protein FtsL
D5285_08840	COG0768	penicillin binding
D5285_08845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D5285_08850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5285_08855	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5285_08860	COG0772	Belongs to the SEDS family
D5285_08865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5285_08870	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D5285_08875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D5285_08880	COG3879	Bacterial protein of unknown function (DUF881)
D5285_08885	COG3879	Bacterial protein of unknown function (DUF881)
D5285_08890	COG3856	small basic protein
D5285_08895	COG0849	cell division
D5285_08900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D5285_08905	COG4412	M6 family metalloprotease domain protein
D5285_08905	COG1404	Belongs to the peptidase S8 family
D5285_08910	COG1404	Belongs to the peptidase S8 family
D5285_08910	COG4412	M6 family metalloprotease domain protein
D5285_08920	COG1191	sigma factor activity
D5285_08925	COG1191	sigma factor activity
D5285_08930	COG1119	ATPase activity
D5285_08935	COG0500	methyltransferase
D5285_08940	COG1873	PFAM PRC-barrel domain
D5285_08950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D5285_08955	COG1799	cell septum assembly
D5285_08960	COG0762	integral membrane protein
D5285_08965	COG2302	S4 RNA-binding domain
D5285_08970	COG3599	regulation of cell shape
D5285_08975	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D5285_08980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5285_08985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D5285_08990	COG0564	pseudouridine synthase activity
D5285_08995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D5285_09000	COG2233	PERMEase
D5285_09005	COG0540	Belongs to the ATCase OTCase family
D5285_09010	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D5285_09015	COG0505	Belongs to the CarA family
D5285_09020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D5285_09025	COG0543	2 iron, 2 sulfur cluster binding
D5285_09030	COG0167	dihydroorotate dehydrogenase activity
D5285_09035	COG0284	orotidine-5'-phosphate decarboxylase activity
D5285_09040	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D5285_09050	COG0175	sulfate reduction
D5285_09055	COG0306	phosphate transporter
D5285_09060	COG2046	Belongs to the sulfate adenylyltransferase family
D5285_09065	COG0529	Catalyzes the synthesis of activated sulfate
D5285_09070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D5285_09075	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D5285_09080	COG1648	precorrin-2 dehydrogenase activity
D5285_09090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D5285_09095	COG1561	YicC-like family, N-terminal region
D5285_09100	COG2052	Domain of unknown function (DUF370)
D5285_09105	COG0194	GDP metabolic process
D5285_09110	COG1758	RNA polymerase activity
D5285_09115	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5285_09120	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D5285_09125	COG0242	peptide deformylase activity
D5285_09130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D5285_09135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5285_09135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D5285_09140	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D5285_09145	COG0631	protein serine/threonine phosphatase activity
D5285_09150	COG0515	serine threonine protein kinase
D5285_09150	COG2815	serine threonine protein kinase
D5285_09155	COG1162	GTPase activity
D5285_09160	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D5285_09165	COG1564	THIamine pyrophosphokinase
D5285_09175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D5285_09180	COG1302	Protein conserved in bacteria
D5285_09185	COG1461	Dihydroxyacetone kinase
D5285_09190	COG1760	l-serine dehydratase
D5285_09195	COG1760	l-serine dehydratase
D5285_09200	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D5285_09205	COG1349	DNA-binding transcription factor activity
D5285_09210	COG0416	fatty acid biosynthetic process
D5285_09215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D5285_09220	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_09225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5285_09230	COG0571	ribonuclease III activity
D5285_09235	COG1196	nuclear chromosome segregation
D5285_09240	COG0552	protein localization to endoplasmic reticulum
D5285_09245	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D5285_09250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D5285_09255	COG0228	four-way junction DNA binding
D5285_09260	COG1837	Belongs to the UPF0109 family
D5285_09270	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D5285_09275	COG0336	Belongs to the RNA methyltransferase TrmD family
D5285_09280	COG0335	large ribosomal subunit rRNA binding
D5285_09285	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5285_09290	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5285_09300	COG2257	FlhB HrpN YscU SpaS Family
D5285_09305	COG0045	succinate-CoA ligase (ADP-forming) activity
D5285_09310	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D5285_09315	COG0758	DNA mediated transformation
D5285_09320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D5285_09325	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D5285_09330	COG4974	Belongs to the 'phage' integrase family
D5285_09335	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D5285_09340	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D5285_09345	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5285_09350	COG1815	bacterial-type flagellum-dependent cell motility
D5285_09355	COG1558	bacterial-type flagellum-dependent cell motility
D5285_09360	COG1677	Flagellar hook-basal body complex protein FliE
D5285_09370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5285_09375	COG1317	bacterial-type flagellum organization
D5285_09380	COG1157	protein secretion by the type III secretion system
D5285_09385	COG2882	bacterial-type flagellum organization
D5285_09395	COG3144	bacterial-type flagellum assembly
D5285_09400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D5285_09405	COG4786	Flagellar basal body rod
D5285_09410	COG1582	Flagellar protein (FlbD)
D5285_09415	COG1580	Controls the rotational direction of flagella during chemotaxis
D5285_09420	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5285_09425	COG1776	CheC inhibitor of MCP methylation
D5285_09425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D5285_09430	COG2201	protein-glutamate methylesterase activity
D5285_09435	COG3190	flagellar
D5285_09440	COG1338	Plays a role in the flagellum-specific transport system
D5285_09445	COG1987	bacterial-type flagellum assembly
D5285_09450	COG1684	flagellar biosynthetic protein fliR
D5285_09455	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5285_09460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D5285_09465	COG1419	protein localization to endoplasmic reticulum
D5285_09470	COG0455	bacterial-type flagellum organization
D5285_09475	COG2201	protein-glutamate methylesterase activity
D5285_09480	COG2198	Histidine kinase
D5285_09480	COG0643	Histidine kinase
D5285_09485	COG0835	chemotaxis
D5285_09490	COG1776	CheC inhibitor of MCP methylation
D5285_09495	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D5285_09500	COG1191	sigma factor activity
D5285_09510	COG0052	Belongs to the universal ribosomal protein uS2 family
D5285_09515	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D5285_09520	COG0528	UMP kinase activity
D5285_09525	COG0233	cytoplasmic translational termination
D5285_09530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D5285_09535	COG4589	Belongs to the CDS family
D5285_09540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D5285_09545	COG0750	zinc metalloprotease
D5285_09550	COG0442	prolyl-tRNA aminoacylation
D5285_09555	COG2176	DNA-directed DNA polymerase activity
D5285_09580	COG0779	Required for maturation of 30S ribosomal subunits
D5285_09585	COG0195	Participates in both transcription termination and antitermination
D5285_09590	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D5285_09595	COG1358	cellular component organization or biogenesis
D5285_09600	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D5285_09605	COG1550	Protein conserved in bacteria
D5285_09610	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D5285_09615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D5285_09620	COG0196	riboflavin kinase activity
D5285_09625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D5285_09630	COG1185	polyribonucleotide nucleotidyltransferase activity
D5285_09635	COG0726	polysaccharide deacetylase
D5285_09640	COG0612	Peptidase, M16
D5285_09645	COG1873	PFAM PRC-barrel domain
D5285_09650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5285_09655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D5285_09660	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D5285_09665	COG0527	aspartate kinase activity
D5285_09675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D5285_09680	COG0740	serine-type endopeptidase activity
D5285_09690	COG4980	gas vesicle protein
D5285_09690	COG1674	ftsk spoiiie
D5285_09695	COG2188	Transcriptional regulator
D5285_09700	COG2814	Major facilitator Superfamily
D5285_09705	COG0612	Peptidase, M16
D5285_09710	COG0612	Peptidase, M16
D5285_09715	COG0300	oxidoreductase activity
D5285_09730	COG1426	Protein conserved in bacteria
D5285_09735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D5285_09740	COG1546	Belongs to the CinA family
D5285_09740	COG1058	Belongs to the CinA family
D5285_09745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D5285_09750	COG1418	mRNA catabolic process
D5285_09755	COG1692	metallophosphoesterase
D5285_09760	COG2359	stage V sporulation protein S
D5285_09770	COG1063	alcohol dehydrogenase
D5285_09775	COG0156	8-amino-7-oxononanoate synthase activity
D5285_09780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5285_09785	COG4550	Control of competence regulator ComK, YlbF/YmcA
D5285_09795	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D5285_09800	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D5285_09805	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D5285_09830	COG0457	Tetratricopeptide repeat
D5285_09845	COG0523	cobalamin synthesis protein
D5285_09865	COG1231	oxidoreductase activity
D5285_09870	COG3619	membrane
D5285_09875	COG3263	regulation of cellular component size
D5285_09880	COG2814	Major facilitator Superfamily
D5285_09895	COG0393	Putative heavy-metal-binding
D5285_09900	COG0398	Pfam SNARE associated Golgi protein
D5285_09905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D5285_09910	COG1819	glycosyl
D5285_09915	COG0531	amino acid
D5285_09920	COG5577	PFAM Coat F domain
D5285_09930	COG3858	chitin binding
D5285_09930	COG1388	LysM domain
D5285_09935	COG1309	transcriptional regulator
D5285_09940	COG3631	Ketosteroid isomerase-related protein
D5285_09945	COG0702	epimerase
D5285_09955	COG1764	response to oxidative stress
D5285_09960	COG2076	Multidrug Resistance protein
D5285_09965	COG2076	Multidrug Resistance protein
D5285_09980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D5285_09985	COG1923	regulation of RNA biosynthetic process
D5285_10000	COG1780	Probably involved in ribonucleotide reductase function
D5285_10005	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5285_10010	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5285_10015	COG4112	unkown
D5285_10035	COG1802	Transcriptional regulator
D5285_10040	COG0697	spore germination
D5285_10070	COG1309	transcriptional regulator
D5285_10105	COG2814	Major facilitator Superfamily
D5285_10110	COG0457	Tetratricopeptide repeat
D5285_10130	COG2732	(Barnase) inhibitor
D5285_10140	COG4413	Urea transporter
D5285_10145	COG0831	urea catabolic process
D5285_10150	COG0832	Belongs to the urease beta subunit family
D5285_10160	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D5285_10165	COG0830	nickel cation binding
D5285_10170	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D5285_10175	COG0829	nickel cation binding
D5285_10185	COG1695	Transcriptional regulator
D5285_10205	COG0464	growth
D5285_10210	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D5285_10215	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D5285_10220	COG0789	Transcriptional regulator
D5285_10225	COG0174	glutamine synthetase
D5285_10280	COG0490	domain, Protein
D5285_10285	COG0475	glutathione-regulated potassium exporter activity
D5285_10295	COG1073	alpha beta
D5285_10335	COG1309	transcriptional regulator
D5285_10340	COG2076	Multidrug Resistance protein
D5285_10345	COG2076	Multidrug Resistance protein
D5285_10350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5285_10365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_10370	COG3546	catalase activity
D5285_10395	COG1846	Transcriptional regulator
D5285_10400	COG0346	lactoylglutathione lyase activity
D5285_10405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5285_10410	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5285_10425	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D5285_10430	COG3209	COG3209 Rhs family protein
D5285_10440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D5285_10445	COG1388	LysM domain
D5285_10450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D5285_10455	COG4224	UPF0291 protein
D5285_10460	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D5285_10470	COG3763	UPF0154 protein
D5285_10480	COG0785	Cytochrome C biogenesis protein
D5285_10485	COG2201	protein-glutamate methylesterase activity
D5285_10490	COG4846	Membrane protein involved in cytochrome C biogenesis
D5285_10500	COG0071	Belongs to the small heat shock protein (HSP20) family
D5285_10515	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D5285_10520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_10540	COG0824	Thioesterase
D5285_10560	COG4841	protein insertion into membrane
D5285_10565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D5285_10570	COG1832	CoA-binding protein
D5285_10575	COG0187	DNA topoisomerase II activity
D5285_10580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D5285_10585	COG1609	Transcriptional regulator
D5285_10600	COG2160	L-arabinose isomerase activity
D5285_10620	COG1115	amino acid carrier protein
D5285_10630	COG2181	nitrate reductase activity
D5285_10635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D5285_10640	COG1140	nitrate reductase beta subunit
D5285_10645	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D5285_10665	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5285_10675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D5285_10680	COG2223	nitrite transmembrane transporter activity
D5285_10700	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D5285_10710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D5285_10730	COG0492	ferredoxin-NADP+ reductase activity
D5285_10745	COG3420	alginic acid biosynthetic process
D5285_10750	COG1114	Component of the transport system for branched-chain amino acids
D5285_10780	COG1024	Enoyl-CoA hydratase
D5285_10785	COG1012	belongs to the aldehyde dehydrogenase family
D5285_10790	COG2084	Dehydrogenase
D5285_10795	COG1960	acyl-CoA dehydrogenase activity
D5285_10800	COG1482	cell wall glycoprotein biosynthetic process
D5285_10805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5285_10805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_10805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5285_10825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_10825	COG3711	transcriptional antiterminator
D5285_10840	COG1725	Transcriptional regulator
D5285_10845	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_10850	COG1312	Catalyzes the dehydration of D-mannonate
D5285_10865	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D5285_10880	COG1609	Transcriptional regulator
D5285_10885	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5285_10890	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D5285_10895	COG0640	Transcriptional regulator
D5285_10900	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D5285_10915	COG1649	PFAM Uncharacterised BCR, COG1649
D5285_10920	COG2404	hydrolase activity, acting on ester bonds
D5285_10925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D5285_10935	COG0438	transferase activity, transferring glycosyl groups
D5285_10940	COG2027	D-alanyl-D-alanine carboxypeptidase
D5285_10960	COG1309	transcriptional regulator
D5285_10965	COG1252	NADH dehydrogenase
D5285_10980	COG0166	Belongs to the GPI family
D5285_10990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5285_10995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5285_11000	COG1024	Enoyl-CoA hydratase
D5285_11005	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5285_11010	COG0511	ligase activity, forming carbon-carbon bonds
D5285_11015	COG0439	Biotin carboxylase
D5285_11020	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D5285_11020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_11025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_11030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_11035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_11040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_11045	COG0318	PFAM AMP-dependent synthetase and ligase
D5285_11050	COG1960	acyl-CoA dehydrogenase activity
D5285_11055	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5285_11060	COG1733	regulation of RNA biosynthetic process
D5285_11065	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D5285_11070	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D5285_11080	COG2323	membrane
D5285_11085	COG0306	phosphate transporter
D5285_11090	COG0175	sulfate reduction
D5285_11095	COG1809	phosphosulfolactate synthase activity
D5285_11100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_11105	COG4948	Mandelate Racemase Muconate Lactonizing
D5285_11110	COG2814	Major facilitator Superfamily
D5285_11115	COG0463	Glycosyl transferase, family 2
D5285_11130	COG0493	'glutamate synthase
D5285_11135	COG0067	glutamate synthase
D5285_11135	COG0069	glutamate synthase activity
D5285_11135	COG0070	glutamate synthase
D5285_11140	COG0583	DNA-binding transcription factor activity
D5285_11165	COG1132	(ABC) transporter
D5285_11175	COG0300	oxidoreductase activity
D5285_11180	COG0574	Belongs to the PEP-utilizing enzyme family
D5285_11180	COG3848	Pyruvate phosphate dikinase
D5285_11185	COG0477	Major facilitator Superfamily
D5285_11190	COG0243	molybdopterin cofactor binding
D5285_11195	COG1846	Transcriptional regulator
D5285_11200	COG2814	Major facilitator Superfamily
D5285_11205	COG0531	amino acid
D5285_11215	COG0531	amino acid
D5285_11220	COG0531	amino acid
D5285_11225	COG0697	spore germination
D5285_11235	COG0840	transmembrane signaling receptor activity
D5285_11240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5285_11245	COG1404	Belongs to the peptidase S8 family
D5285_11255	COG1309	transcriptional regulator
D5285_11260	COG1846	Transcriptional regulator
D5285_11290	COG1309	transcriptional regulator
D5285_11295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5285_11300	COG3708	Transcriptional regulator
D5285_11310	COG2378	regulation of single-species biofilm formation
D5285_11320	COG0640	Transcriptional regulator
D5285_11335	COG0531	amino acid
D5285_11340	COG0741	lytic transglycosylase activity
D5285_11345	COG1086	Polysaccharide biosynthesis protein
D5285_11360	COG0438	transferase activity, transferring glycosyl groups
D5285_11365	COG2322	membrane
D5285_11380	COG1619	proteins homologs of microcin C7 resistance protein MccF
D5285_11385	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5285_11390	COG1388	LysM domain
D5285_11390	COG3584	3D domain protein
D5285_11395	COG0514	ATP-dependent DNA helicase (RecQ)
D5285_11415	COG2315	Protein conserved in bacteria
D5285_11425	COG2427	Protein of unknown function (DUF1641)
D5285_11430	COG3383	formate dehydrogenase (NAD+) activity
D5285_11445	COG5444	nuclease activity
D5285_11460	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D5285_11490	COG2350	Protein conserved in bacteria
D5285_11515	COG0402	S-adenosylhomocysteine deaminase activity
D5285_11530	COG2267	carboxylic ester hydrolase activity
D5285_11545	COG1280	lysine exporter protein (LysE YggA)
D5285_11555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D5285_11565	COG0574	Belongs to the PEP-utilizing enzyme family
D5285_11565	COG3848	Pyruvate phosphate dikinase
D5285_11585	COG2318	DinB family
D5285_11590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5285_11615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5285_11630	COG1012	belongs to the aldehyde dehydrogenase family
D5285_11650	COG1657	PFAM Prenyltransferase squalene oxidase
D5285_11655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5285_11665	COG0733	neurotransmitter:sodium symporter activity
D5285_11670	COG0385	Bile acid
D5285_11675	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5285_11680	COG0567	Dehydrogenase, E1 component
D5285_11685	COG4548	von Willebrand factor, type A
D5285_11690	COG0714	Associated with various cellular activities
D5285_11695	COG2032	superoxide dismutase activity
D5285_11700	COG1388	LysM domain
D5285_11700	COG0791	NLP P60 protein
D5285_11710	COG0534	Mate efflux family protein
D5285_11715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5285_11720	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5285_11730	COG2962	Rard protein
D5285_11740	COG4305	rare lipoprotein A
D5285_11755	COG1733	regulation of RNA biosynthetic process
D5285_11760	COG0778	Nitroreductase
D5285_11765	COG0400	carboxylic ester hydrolase activity
D5285_11775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5285_11780	COG0793	Belongs to the peptidase S41A family
D5285_11780	COG3409	Peptidoglycan-binding domain 1 protein
D5285_11785	COG2226	methyltransferase
D5285_11795	COG1876	peptidase activity
D5285_11800	COG0813	purine-nucleoside phosphorylase activity
D5285_11805	COG0701	Predicted permease
D5285_11825	COG0671	phosphoesterase, PA-phosphatase related
D5285_11840	COG4479	Belongs to the UPF0346 family
D5285_11850	COG1509	lysine 2,3-aminomutase activity
D5285_11855	COG0456	acetyltransferase
D5285_11860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5285_11865	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D5285_11870	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D5285_11875	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D5285_11890	COG0456	acetyltransferase
D5285_11915	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5285_11920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D5285_11925	COG1846	Transcriptional regulator
D5285_11935	COG3706	GGDEF domain
D5285_11940	COG0534	Mate efflux family protein
D5285_11955	COG4698	Protein conserved in bacteria
D5285_11960	COG2755	lipolytic protein G-D-S-L family
D5285_11965	COG1999	signal sequence binding
D5285_11985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D5285_11990	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D5285_11995	COG1272	protein, Hemolysin III
D5285_12000	COG0204	Acyl-transferase
D5285_12005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D5285_12015	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5285_12025	COG2136	Putative SAM-dependent methyltransferase
D5285_12025	COG2521	methyltransferase
D5285_12035	COG0129	dihydroxy-acid dehydratase activity
D5285_12040	COG1413	lyase activity
D5285_12050	COG0386	Belongs to the glutathione peroxidase family
D5285_12055	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D5285_12060	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D5285_12065	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5285_12075	COG1278	Cold shock
D5285_12095	COG0328	RNA-DNA hybrid ribonuclease activity
D5285_12100	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D5285_12105	COG0328	RNA-DNA hybrid ribonuclease activity
D5285_12115	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5285_12125	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D5285_12135	COG1755	Isoprenylcysteine carboxyl methyltransferase
D5285_12140	COG3424	synthase
D5285_12150	COG2233	PERMEase
D5285_12155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5285_12160	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D5285_12165	COG1199	ATP-dependent helicase activity
D5285_12185	COG0116	Belongs to the methyltransferase superfamily
D5285_12195	COG3599	regulation of cell shape
D5285_12200	COG4474	Belongs to the UPF0398 family
D5285_12210	COG3359	exonuclease
D5285_12215	COG1111	helicase
D5285_12215	COG1205	dead DEAH box helicase
D5285_12220	COG2190	(PTS) system
D5285_12225	COG0071	Belongs to the small heat shock protein (HSP20) family
D5285_12260	COG3331	DNA recombination
D5285_12265	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5285_12265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5285_12275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D5285_12280	COG3935	DnaD domain protein
D5285_12285	COG0017	Asparaginyl-tRNA synthetase
D5285_12290	COG0436	Aminotransferase
D5285_12295	COG5353	protein conserved in bacteria
D5285_12305	COG1199	ATP-dependent helicase activity
D5285_12305	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D5285_12310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D5285_12315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D5285_12320	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D5285_12335	COG0617	tRNA 3'-terminal CCA addition
D5285_12340	COG0438	transferase activity, transferring glycosyl groups
D5285_12345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D5285_12350	COG1803	Methylglyoxal synthase
D5285_12355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D5285_12360	COG1694	Mazg nucleotide pyrophosphohydrolase
D5285_12365	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_12375	COG4347	Protein of unknown function (DUF1405)
D5285_12380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5285_12380	COG2010	Cytochrome c
D5285_12385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D5285_12390	COG0723	plastoquinol--plastocyanin reductase activity
D5285_12400	COG5582	Belongs to the UPF0302 family
D5285_12405	COG0457	Tetratricopeptide repeat
D5285_12410	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D5285_12415	COG0287	Prephenate dehydrogenase
D5285_12420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D5285_12425	COG0159	tryptophan synthase activity
D5285_12430	COG0133	tryptophan synthase activity
D5285_12435	COG0135	phosphoribosylanthranilate isomerase activity
D5285_12440	COG0134	indole-3-glycerol-phosphate synthase activity
D5285_12445	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D5285_12450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D5285_12455	COG4401	Chorismate mutase type I
D5285_12460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D5285_12465	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D5285_12470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D5285_12475	COG0105	UTP biosynthetic process
D5285_12480	COG0142	geranyltranstransferase activity
D5285_12485	COG2226	methyltransferase
D5285_12490	COG0142	geranyltranstransferase activity
D5285_12505	COG0776	regulation of translation
D5285_12510	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D5285_12530	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D5285_12535	COG1160	GTP binding
D5285_12560	COG1304	FMN binding
D5285_12565	COG0539	negative regulation of cytoplasmic translation
D5285_12570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D5285_12580	COG2959	enzyme of heme biosynthesis
D5285_12585	COG3773	Cell wall hydrolase
D5285_12585	COG3409	Peptidoglycan-binding domain 1 protein
D5285_12590	COG2339	peptidase activity
D5285_12600	COG0492	ferredoxin-NADP+ reductase activity
D5285_12605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5285_12610	COG4862	establishment of competence for transformation
D5285_12615	COG1408	metallophosphoesterase
D5285_12630	COG1388	LysM domain
D5285_12635	COG1266	CAAX protease self-immunity
D5285_12640	COG0514	ATP-dependent DNA helicase (RecQ)
D5285_12645	COG4955	Helix-turn-helix domain
D5285_12650	COG1141	Ferredoxin
D5285_12655	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D5285_12660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D5285_12665	COG0739	heme binding
D5285_12675	COG1595	DNA-templated transcription, initiation
D5285_12695	COG5002	protein histidine kinase activity
D5285_12700	COG0745	RESPONSE REGULATOR receiver
D5285_12705	COG5002	protein histidine kinase activity
D5285_12710	COG0745	RESPONSE REGULATOR receiver
D5285_12715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5285_12720	COG1333	cytochrome c biogenesis protein
D5285_12725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_12730	COG1187	pseudouridine synthase activity
D5285_12735	COG0700	Nucleoside recognition
D5285_12740	COG2715	membrane protein required for spore maturation
D5285_12745	COG1686	Belongs to the peptidase S11 family
D5285_12755	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D5285_12760	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D5285_12770	COG1547	Domain of unknown function (DUF309)
D5285_12780	COG0456	acetyltransferase
D5285_12785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D5285_12790	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5285_12790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D5285_12795	COG0307	riboflavin synthase, alpha
D5285_12800	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5285_12800	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D5285_12820	COG0457	Tetratricopeptide repeat
D5285_12825	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D5285_12830	COG4086	secreted protein
D5285_12835	COG4195	phage-related replication protein
D5285_12845	COG0019	diaminopimelate decarboxylase activity
D5285_12855	COG0697	spore germination
D5285_12870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D5285_12905	COG1686	Belongs to the peptidase S11 family
D5285_12910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D5285_12915	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D5285_12920	COG4974	Belongs to the 'phage' integrase family
D5285_12930	COG0735	belongs to the Fur family
D5285_12935	COG1300	Membrane
D5285_12940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_12950	COG1953	Uracil, thiamine, allantoin
D5285_12960	COG2153	protein acetylation
D5285_12965	COG1379	DNA repair
D5285_12970	COG0494	nUDIX hydrolase
D5285_12980	COG1309	transcriptional regulator
D5285_12990	COG0667	Aldo Keto reductase
D5285_13000	COG1073	alpha beta
D5285_13010	COG4918	Iron-sulphur cluster biosynthesis
D5285_13020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D5285_13020	COG0456	acetyltransferase
D5285_13025	COG2329	Antibiotic biosynthesis monooxygenase
D5285_13030	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D5285_13040	COG0747	negative chemotaxis
D5285_13045	COG0601	transmembrane transport
D5285_13050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5285_13055	COG0444	Belongs to the ABC transporter superfamily
D5285_13065	COG0534	Mate efflux family protein
D5285_13080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5285_13090	COG2211	Major facilitator Superfamily
D5285_13095	COG0346	lactoylglutathione lyase activity
D5285_13100	COG1072	(Pantothenic acid kinase))
D5285_13145	COG2205	protein histidine kinase activity
D5285_13150	COG0745	RESPONSE REGULATOR receiver
D5285_13175	COG2814	Major facilitator Superfamily
D5285_13185	COG4195	phage-related replication protein
D5285_13195	COG0300	oxidoreductase activity
D5285_13200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5285_13205	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5285_13210	COG4187	Peptidase family M20/M25/M40
D5285_13215	COG1902	pentaerythritol trinitrate reductase activity
D5285_13220	COG0596	Alpha beta hydrolase
D5285_13225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5285_13230	COG1234	tRNA 3'-trailer cleavage
D5285_13235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D5285_13255	COG2188	Transcriptional regulator
D5285_13260	COG2723	6-phospho-beta-galactosidase activity
D5285_13265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_13270	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5285_13275	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_13280	COG1785	Belongs to the alkaline phosphatase family
D5285_13285	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_13290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D5285_13295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D5285_13305	COG0706	membrane insertase activity
D5285_13310	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5285_13315	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D5285_13320	COG4129	membrane
D5285_13325	COG1126	abc transporter atp-binding protein
D5285_13330	COG0765	amino acid transport
D5285_13335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D5285_13355	COG1597	lipid kinase activity
D5285_13360	COG0508	dehydrogenase complex catalyzes the overall conversion of
D5285_13365	COG0022	dehydrogenase e1 component
D5285_13370	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D5285_13375	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D5285_13380	COG3426	butyrate kinase activity
D5285_13390	COG0280	phosphate acetyltransferase
D5285_13395	COG3829	transcription factor binding
D5285_13395	COG3290	protein histidine kinase activity
D5285_13405	COG0584	glycerophosphoryl diester phosphodiesterase
D5285_13410	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5285_13435	COG0745	RESPONSE REGULATOR receiver
D5285_13440	COG0750	zinc metalloprotease
D5285_13445	COG0497	DNA recombination
D5285_13450	COG1438	arginine binding
D5285_13455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D5285_13460	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D5285_13465	COG0142	geranyltranstransferase activity
D5285_13470	COG1722	exodeoxyribonuclease VII activity
D5285_13475	COG1570	exodeoxyribonuclease VII activity
D5285_13480	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D5285_13485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D5285_13490	COG1302	Protein conserved in bacteria
D5285_13495	COG0439	Biotin carboxylase
D5285_13500	COG0511	ligase activity, forming carbon-carbon bonds
D5285_13540	COG3854	ATPases associated with a variety of cellular activities
D5285_13550	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D5285_13555	COG0006	proline dipeptidase activity
D5285_13560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D5285_13570	COG3872	metal-dependent enzyme
D5285_13580	COG1752	Esterase of the alpha-beta hydrolase superfamily
D5285_13585	COG1321	iron dependent repressor
D5285_13590	COG0095	Lipoate-protein ligase
D5285_13595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5285_13600	COG2113	Glycine betaine
D5285_13605	COG4176	ABC-type proline glycine betaine transport system permease component
D5285_13610	COG0517	IMP dehydrogenase activity
D5285_13610	COG4175	Glycine betaine
D5285_13615	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5285_13620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D5285_13625	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D5285_13635	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5285_13660	COG0681	Belongs to the peptidase S26 family
D5285_13685	COG4940	Competence protein ComGF
D5285_13695	COG4970	Tfp pilus assembly protein FimT
D5285_13700	COG4537	Required for transformation and DNA binding
D5285_13705	COG1459	type II secretion system
D5285_13710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D5285_13715	COG1366	Belongs to the anti-sigma-factor antagonist family
D5285_13725	COG1393	Belongs to the ArsC family
D5285_13735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5285_13745	COG0011	TIGRFAM Protein of
D5285_13755	COG2866	Carboxypeptidase
D5285_13760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_13765	COG1368	sulfuric ester hydrolase activity
D5285_13770	COG1940	carbohydrate kinase activity
D5285_13775	COG4483	Protein conserved in bacteria
D5285_13780	COG0697	spore germination
D5285_13785	COG0457	Tetratricopeptide repeat
D5285_13785	COG0705	Rhomboid family
D5285_13790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D5285_13795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D5285_13815	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5285_13865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5285_13870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D5285_13875	COG0581	inorganic phosphate transmembrane transporter activity
D5285_13880	COG0573	inorganic phosphate transmembrane transporter activity
D5285_13885	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D5285_13895	COG0477	Major facilitator Superfamily
D5285_13900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D5285_13905	COG2839	Protein conserved in bacteria
D5285_13910	COG5521	maltodextrose utilization protein MalA
D5285_13915	COG1388	LysM domain
D5285_13920	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D5285_13925	COG4709	membrane
D5285_13930	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D5285_13935	COG0735	belongs to the Fur family
D5285_13940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5285_13945	COG1121	(ABC) transporter
D5285_13950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_13960	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D5285_13965	COG0513	Belongs to the DEAD box helicase family
D5285_13975	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D5285_13980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D5285_13985	COG2384	SAM-dependent methyltransferase
D5285_14010	COG5444	nuclease activity
D5285_14025	COG2010	Cytochrome c
D5285_14030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D5285_14035	COG0358	DNA primase activity
D5285_14040	COG1671	Belongs to the UPF0178 family
D5285_14045	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D5285_14050	COG0517	IMP dehydrogenase activity
D5285_14055	COG0751	glycine-tRNA ligase activity
D5285_14060	COG0752	glycyl-tRNA synthetase alpha subunit
D5285_14065	COG1381	Involved in DNA repair and RecF pathway recombination
D5285_14075	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D5285_14080	COG0295	cytidine deaminase activity
D5285_14085	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D5285_14090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D5285_14095	COG1480	7TM receptor with intracellular HD hydrolase
D5285_14100	COG1702	phosphate starvation-inducible protein PhoH
D5285_14105	COG0561	phosphatase activity
D5285_14120	COG4864	UPF0365 protein
D5285_14125	COG1030	water channel activity
D5285_14130	COG1610	YqeY-like protein
D5285_14135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D5285_14140	COG1283	sodium-dependent phosphate transmembrane transporter activity
D5285_14145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5285_14150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D5285_14155	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D5285_14160	COG2264	protein methyltransferase activity
D5285_14165	COG0484	heat shock protein binding
D5285_14170	COG0443	Heat shock 70 kDa protein
D5285_14175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D5285_14180	COG1420	regulation of RNA biosynthetic process
D5285_14185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D5285_14190	COG0481	GTPase activity
D5285_14200	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5285_14205	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D5285_14210	COG0268	Binds directly to 16S ribosomal RNA
D5285_14220	COG1733	regulation of RNA biosynthetic process
D5285_14225	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5285_14230	COG1466	dna polymerase III delta subunit
D5285_14240	COG0658	competence protein
D5285_14240	COG2333	competence protein COMEC
D5285_14245	COG2131	deaminase
D5285_14250	COG1596	polysaccharide export
D5285_14250	COG1555	photosystem II stabilization
D5285_14255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D5285_14260	COG2226	methyltransferase
D5285_14265	COG0799	negative regulation of ribosome biogenesis
D5285_14270	COG1713	HD superfamily hydrolase involved in NAD metabolism
D5285_14275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D5285_14280	COG1534	Rna-binding protein
D5285_14285	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D5285_14290	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D5285_14295	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D5285_14305	COG2755	lipolytic protein G-D-S-L family
D5285_14315	COG5609	conserved protein (DUF2294)
D5285_14320	COG3383	formate dehydrogenase (NAD+) activity
D5285_14325	COG2427	Protein of unknown function (DUF1641)
D5285_14365	COG2723	6-phospho-beta-galactosidase activity
D5285_14370	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5285_14375	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_14390	COG0561	phosphatase activity
D5285_14395	COG1486	melibiose metabolic process
D5285_14410	COG4978	Transcriptional regulator
D5285_14410	COG0789	Transcriptional regulator
D5285_14425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D5285_14430	COG2828	Protein conserved in bacteria
D5285_14440	COG2181	nitrate reductase activity
D5285_14445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D5285_14450	COG1140	nitrate reductase beta subunit
D5285_14455	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D5285_14460	COG2223	nitrite transmembrane transporter activity
D5285_14470	COG3226	Transcriptional regulator
D5285_14505	COG2197	response regulator
D5285_14510	COG4585	Histidine kinase
D5285_14515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_14520	COG0730	response to heat
D5285_14525	COG0425	Belongs to the sulfur carrier protein TusA family
D5285_14530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5285_14530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5285_14535	COG0425	Belongs to the sulfur carrier protein TusA family
D5285_14535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5285_14540	COG2210	Belongs to the sulfur carrier protein TusA family
D5285_14545	COG1937	Protein conserved in bacteria
D5285_14580	COG1942	4-Oxalocrotonate Tautomerase
D5285_14585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D5285_14590	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D5285_14595	COG1733	regulation of RNA biosynthetic process
D5285_14600	COG3239	Fatty acid desaturase
D5285_14605	COG4585	Histidine kinase
D5285_14610	COG2197	response regulator
D5285_14615	COG0492	ferredoxin-NADP+ reductase activity
D5285_14620	COG0747	negative chemotaxis
D5285_14625	COG0601	transmembrane transport
D5285_14630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D5285_14635	COG0444	Belongs to the ABC transporter superfamily
D5285_14640	COG4608	Belongs to the ABC transporter superfamily
D5285_14660	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_14675	COG2124	cytochrome p450
D5285_14680	COG0730	response to heat
D5285_14685	COG3507	Belongs to the glycosyl hydrolase 43 family
D5285_14690	COG2211	Major facilitator Superfamily
D5285_14700	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_14705	COG1621	beta-fructofuranosidase activity
D5285_14710	COG3716	PTS system mannose fructose sorbose family IID component
D5285_14715	COG3715	PTS system
D5285_14720	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_14725	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_14730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D5285_14730	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D5285_14750	COG2169	Transcriptional regulator
D5285_14755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D5285_14760	COG2205	protein histidine kinase activity
D5285_14785	COG0656	L-ascorbic acid biosynthetic process
D5285_14790	COG2814	Major facilitator Superfamily
D5285_14795	COG1733	regulation of RNA biosynthetic process
D5285_14800	COG3340	Belongs to the peptidase S51 family
D5285_14805	COG1587	Uroporphyrinogen-III synthase
D5285_14815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_14820	COG0583	DNA-binding transcription factor activity
D5285_14825	COG2814	Major facilitator Superfamily
D5285_14835	COG2124	cytochrome p450
D5285_14835	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D5285_14840	COG1309	transcriptional regulator
D5285_14845	COG1404	Belongs to the peptidase S8 family
D5285_14850	COG2226	methyltransferase
D5285_14870	COG0626	cystathionine gamma-synthase activity
D5285_14875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5285_14880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D5285_14885	COG2226	methyltransferase
D5285_14900	COG0768	penicillin binding
D5285_14905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D5285_14910	COG0572	uridine kinase
D5285_14930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D5285_14935	COG3906	Belongs to the UPF0473 family
D5285_14940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D5285_14945	COG4472	Bacterial protein of unknown function (DUF965)
D5285_14950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D5285_14955	COG0628	permease
D5285_14970	COG3881	PFAM PRC-barrel domain
D5285_14975	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5285_14980	COG0457	Tetratricopeptide repeat
D5285_14985	COG0482	sulfurtransferase activity
D5285_14990	COG1104	cysteine desulfurase activity
D5285_14995	COG1959	2 iron, 2 sulfur cluster binding
D5285_15000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D5285_15005	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D5285_15015	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D5285_15020	COG0124	histidyl-tRNA synthetase
D5285_15025	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5285_15025	COG3103	Sh3 type 3 domain protein
D5285_15025	COG4991	sh3 domain protein
D5285_15030	COG1490	D-aminoacyl-tRNA deacylase activity
D5285_15035	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D5285_15040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D5285_15045	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D5285_15045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D5285_15050	COG5416	Lipopolysaccharide assembly protein A domain
D5285_15055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5285_15055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D5285_15065	COG2244	polysaccharide biosynthetic process
D5285_15070	COG2323	membrane
D5285_15080	COG1862	Preprotein translocase
D5285_15085	COG0343	queuine tRNA-ribosyltransferase activity
D5285_15090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D5285_15100	COG2255	four-way junction helicase activity
D5285_15105	COG0632	four-way junction helicase activity
D5285_15115	COG2112	serine threonine protein kinase
D5285_15125	COG2318	DinB family
D5285_15130	COG4195	phage-related replication protein
D5285_15145	COG0217	transcriptional regulatory protein
D5285_15155	COG1388	LysM domain
D5285_15160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D5285_15165	COG0157	Belongs to the NadC ModD family
D5285_15170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D5285_15175	COG1104	cysteine desulfurase activity
D5285_15180	COG1827	regulation of RNA biosynthetic process
D5285_15185	COG0077	Prephenate dehydratase
D5285_15190	COG4492	Belongs to the UPF0735 family
D5285_15195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D5285_15200	COG3290	protein histidine kinase activity
D5285_15205	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D5285_15210	COG2868	ribosomal protein
D5285_15215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D5285_15220	COG1994	Peptidase M50
D5285_15225	COG0739	heme binding
D5285_15230	COG3832	glyoxalase III activity
D5285_15235	COG0640	Transcriptional regulator
D5285_15240	COG2894	cell division
D5285_15245	COG0850	regulation of cytokinetic process
D5285_15250	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D5285_15255	COG1792	Involved in formation and maintenance of cell shape
D5285_15260	COG1077	Cell shape determining protein MreB Mrl
D5285_15330	COG5434	Belongs to the glycosyl hydrolase 28 family
D5285_15335	COG1388	LysM domain
D5285_15335	COG1705	Flagellar rod assembly protein muramidase FlgJ
D5285_15410	COG1802	Transcriptional regulator
D5285_15410	COG4626	Terminase
D5285_15525	COG1396	sequence-specific DNA binding
D5285_15540	COG2003	Belongs to the UPF0758 family
D5285_15545	COG0424	maF-like protein
D5285_15555	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D5285_15560	COG0285	dihydrofolate synthase activity
D5285_15565	COG0525	valine-tRNA ligase activity
D5285_15575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5285_15580	COG1388	LysM domain
D5285_15585	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D5285_15590	COG0113	porphobilinogen synthase activity
D5285_15595	COG1587	Uroporphyrinogen-III synthase
D5285_15600	COG0181	hydroxymethylbilane synthase activity
D5285_15605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D5285_15610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D5285_15620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D5285_15625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D5285_15630	COG1067	ATP-dependent peptidase activity
D5285_15630	COG0470	DNA polymerase III
D5285_15635	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D5285_15640	COG0544	peptidyl-prolyl cis-trans isomerase activity
D5285_15645	COG1477	protein flavinylation
D5285_15645	COG0457	Tetratricopeptide repeat
D5285_15650	COG0066	3-isopropylmalate dehydratase activity
D5285_15655	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D5285_15660	COG0473	3-isopropylmalate dehydrogenase activity
D5285_15665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D5285_15670	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D5285_15675	COG0440	acetolactate synthase activity
D5285_15680	COG0028	Belongs to the TPP enzyme family
D5285_15685	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5285_15695	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D5285_15715	COG0622	Phosphoesterase
D5285_15720	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D5285_15725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D5285_15730	COG5401	PFAM Sporulation and spore germination
D5285_15735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D5285_15740	COG1846	Transcriptional regulator
D5285_15745	COG2197	response regulator
D5285_15750	COG4221	oxidoreductase activity
D5285_15755	COG0824	Thioesterase
D5285_15760	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D5285_15765	COG1053	succinate dehydrogenase
D5285_15770	COG2009	succinate dehydrogenase
D5285_15775	COG1719	4-vinyl reductase, 4VR
D5285_15780	COG0527	aspartate kinase activity
D5285_15790	COG0322	excinuclease ABC activity
D5285_15795	COG3118	belongs to the thioredoxin family
D5285_15800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D5285_15805	COG2086	electron transfer activity
D5285_15810	COG1024	Enoyl-CoA hydratase
D5285_15815	COG1309	transcriptional regulator
D5285_15820	COG0318	PFAM AMP-dependent synthetase and ligase
D5285_15825	COG3766	membrane
D5285_15830	COG1193	negative regulation of DNA recombination
D5285_15835	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5285_15835	COG1796	DNA polymerase
D5285_15840	COG1286	toxin biosynthetic process
D5285_15845	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D5285_15850	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D5285_15870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5285_15870	COG0072	phenylalanine-tRNA ligase activity
D5285_15875	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D5285_15880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D5285_15890	COG1966	Carbon starvation protein
D5285_15895	COG1309	transcriptional regulator
D5285_15900	COG3402	PFAM membrane-flanked domain
D5285_15920	COG0395	ABC-type sugar transport system, permease component
D5285_15925	COG1175	transmembrane transport
D5285_15930	COG1653	transport
D5285_15935	COG0371	Dehydrogenase
D5285_15940	COG0235	Class ii aldolase
D5285_15945	COG1069	ribulokinase activity
D5285_15950	COG2160	L-arabinose isomerase activity
D5285_15955	COG3507	Belongs to the glycosyl hydrolase 43 family
D5285_15960	COG1363	Peptidase, m42
D5285_15970	COG3326	Membrane
D5285_15975	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D5285_15980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D5285_15985	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D5285_15990	COG1346	cytolysis
D5285_16000	COG3540	Alkaline phosphatase
D5285_16005	COG3279	Response regulator of the LytR AlgR family
D5285_16010	COG3275	phosphorelay sensor kinase activity
D5285_16025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D5285_16035	COG0398	Pfam SNARE associated Golgi protein
D5285_16040	COG1484	DNA-dependent DNA replication
D5285_16045	COG3611	Membrane attachment protein
D5285_16050	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D5285_16065	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D5285_16070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5285_16075	COG3866	Pectate lyase
D5285_16080	COG0237	dephospho-CoA kinase activity
D5285_16085	COG1971	Probably functions as a manganese efflux pump
D5285_16090	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D5285_16095	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5285_16095	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5285_16100	COG5002	protein histidine kinase activity
D5285_16105	COG0745	RESPONSE REGULATOR receiver
D5285_16110	COG0039	L-malate dehydrogenase activity
D5285_16115	COG0538	isocitrate dehydrogenase activity
D5285_16120	COG0372	Belongs to the citrate synthase family
D5285_16130	COG2273	Hydrolase Family 16
D5285_16140	COG2707	UPF0756 membrane protein
D5285_16145	COG0628	permease
D5285_16150	COG3030	protein affecting phage T7 exclusion by the F plasmid
D5285_16160	COG0205	6-phosphofructokinase activity
D5285_16165	COG0825	malonyl-CoA metabolic process
D5285_16170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D5285_16175	COG0281	malic enzyme
D5285_16180	COG0587	DNA-directed DNA polymerase activity
D5285_16200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D5285_16210	COG4109	DRTGG domain
D5285_16215	COG1695	Transcriptional regulator
D5285_16220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D5285_16225	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_16230	COG0165	Argininosuccinate lyase
D5285_16235	COG0137	argininosuccinate synthase activity
D5285_16240	COG0521	Mo-molybdopterin cofactor biosynthetic process
D5285_16245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D5285_16250	COG0827	DNA restriction-modification system
D5285_16255	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D5285_16260	COG3874	Sporulation protein YtfJ
D5285_16270	COG1714	RDD family
D5285_16275	COG0616	signal peptide processing
D5285_16280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D5285_16285	COG1846	Transcriptional regulator
D5285_16290	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5285_16300	COG0301	tRNA thio-modification
D5285_16305	COG1104	cysteine desulfurase activity
D5285_16310	COG1114	Component of the transport system for branched-chain amino acids
D5285_16315	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D5285_16320	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D5285_16325	COG1309	transcriptional regulator
D5285_16330	COG1956	GAF domain-containing protein
D5285_16335	COG2203	Gaf domain
D5285_16335	COG2199	diguanylate cyclase activity
D5285_16340	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D5285_16355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D5285_16360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D5285_16365	COG0454	-acetyltransferase
D5285_16370	COG0517	IMP dehydrogenase activity
D5285_16375	COG0123	including yeast histone deacetylase and acetoin utilization protein
D5285_16380	COG1360	Flagellar Motor Protein
D5285_16385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D5285_16390	COG1609	Transcriptional regulator
D5285_16395	COG1605	Chorismate mutase
D5285_16395	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D5285_16405	COG3118	belongs to the thioredoxin family
D5285_16410	COG4980	gas vesicle protein
D5285_16415	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D5285_16420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D5285_16425	COG1674	ftsk spoiiie
D5285_16430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D5285_16435	COG4848	Belongs to the UPF0354 family
D5285_16440	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_16450	COG1363	Peptidase, m42
D5285_16455	COG5584	Small secreted protein
D5285_16460	COG0281	malic enzyme
D5285_16465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D5285_16470	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D5285_16480	COG0510	thiamine kinase activity
D5285_16485	COG1523	belongs to the glycosyl hydrolase 13 family
D5285_16490	COG1597	lipid kinase activity
D5285_16500	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D5285_16505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D5285_16520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D5285_16525	COG2252	PERMEase
D5285_16530	COG4473	ABC transporter
D5285_16535	COG1131	(ABC) transporter
D5285_16540	COG1349	DNA-binding transcription factor activity
D5285_16545	COG1187	pseudouridine synthase activity
D5285_16550	COG2244	polysaccharide biosynthetic process
D5285_16555	COG2081	HI0933 family
D5285_16560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D5285_16570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5285_16585	COG5578	integral membrane protein
D5285_16590	COG0673	inositol 2-dehydrogenase activity
D5285_16595	COG1653	transport
D5285_16600	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D5285_16605	COG4209	transmembrane transport
D5285_16610	COG2207	Transcriptional regulator
D5285_16615	COG1653	transport
D5285_16620	COG0395	ABC-type sugar transport system, permease component
D5285_16625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5285_16630	COG1073	alpha beta
D5285_16640	COG0583	DNA-binding transcription factor activity
D5285_16645	COG0346	lactoylglutathione lyase activity
D5285_16650	COG0495	leucyl-tRNA aminoacylation
D5285_16660	COG2814	Major facilitator Superfamily
D5285_16665	COG1464	Belongs to the NlpA lipoprotein family
D5285_16675	COG0577	efflux transmembrane transporter activity
D5285_16680	COG1136	(ABC) transporter
D5285_16690	COG1131	(ABC) transporter
D5285_16695	COG1725	Transcriptional regulator
D5285_16705	COG1242	4 iron, 4 sulfur cluster binding
D5285_16710	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D5285_16720	COG2267	carboxylic ester hydrolase activity
D5285_16725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D5285_16730	COG0671	phosphoesterase, PA-phosphatase related
D5285_16735	COG0438	transferase activity, transferring glycosyl groups
D5285_16735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5285_16740	COG0367	asparagine synthase
D5285_16745	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D5285_16750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D5285_16765	COG1506	peptidase
D5285_16770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D5285_16775	COG1116	anion transmembrane transporter activity
D5285_16780	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D5285_16785	COG0494	nUDIX hydrolase
D5285_16795	COG4824	toxin secretion phage lysis holin
D5285_16800	COG0783	Belongs to the Dps family
D5285_16815	COG1854	S-ribosylhomocysteine lyase activity
D5285_16820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D5285_16825	COG0288	reversible hydration of carbon dioxide
D5285_16830	COG0523	cobalamin synthesis protein
D5285_16835	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5285_16840	COG0254	rRNA binding
D5285_16845	COG1271	oxidase subunit
D5285_16850	COG1294	oxidase, subunit
D5285_16865	COG4948	Mandelate Racemase Muconate Lactonizing
D5285_16870	COG0318	PFAM AMP-dependent synthetase and ligase
D5285_16875	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D5285_16880	COG0596	Alpha beta hydrolase
D5285_16885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D5285_16890	COG1169	isochorismate synthase
D5285_16895	COG1575	Belongs to the MenA family. Type 1 subfamily
D5285_16900	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D5285_16905	COG0058	SHG alpha-glucan phosphorylase activity
D5285_16910	COG0297	glycogen (starch) synthase activity
D5285_16915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5285_16920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D5285_16925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D5285_17050	COG1609	Transcriptional regulator
D5285_17055	COG3859	Proton-coupled thiamine transporter YuaJ
D5285_17060	COG3764	Sortase (surface protein transpeptidase)
D5285_17075	COG0457	Tetratricopeptide repeat
D5285_17080	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D5285_17085	COG0569	domain protein
D5285_17100	COG2318	DinB family
D5285_17110	COG1454	alcohol dehydrogenase
D5285_17125	COG1510	regulation of RNA biosynthetic process
D5285_17135	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D5285_17140	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D5285_17175	COG1388	LysM domain
D5285_17175	COG5632	N-Acetylmuramoyl-L-alanine amidase
D5285_17175	COG3409	Peptidoglycan-binding domain 1 protein
D5285_17315	COG1793	dna ligase
D5285_17370	COG3584	3D domain protein
D5285_17375	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D5285_17410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D5285_17415	COG1780	Probably involved in ribonucleotide reductase function
D5285_17450	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5285_17450	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D5285_17580	COG4974	Belongs to the 'phage' integrase family
D5285_17590	COG1397	ADP-ribosylglycohydrolase
D5285_17680	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D5285_17690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D5285_17695	COG0726	polysaccharide deacetylase
D5285_17700	COG1408	metallophosphoesterase
D5285_17705	COG1968	undecaprenyl-diphosphatase activity
D5285_17710	COG0628	permease
D5285_17715	COG0673	inositol 2-dehydrogenase activity
D5285_17720	COG0693	protein deglycase activity
D5285_17725	COG0840	transmembrane signaling receptor activity
D5285_17730	COG0840	transmembrane signaling receptor activity
D5285_17735	COG0840	transmembrane signaling receptor activity
D5285_17745	COG2070	2-Nitropropane dioxygenase
D5285_17750	COG0432	Pfam Uncharacterised protein family UPF0047
D5285_17755	COG0366	Alpha amylase catalytic
D5285_17770	COG5297	Belongs to the glycosyl hydrolase family 6
D5285_17775	COG1253	flavin adenine dinucleotide binding
D5285_17780	COG2738	Putative neutral zinc metallopeptidase
D5285_17795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D5285_17805	COG2323	membrane
D5285_17810	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D5285_17820	COG0166	Belongs to the GPI family
D5285_17825	COG1979	alcohol dehydrogenase
D5285_17830	COG2155	Conserved Protein
D5285_17835	COG1098	S1 RNA binding domain
D5285_17840	COG0436	Aminotransferase
D5285_17845	COG1522	sequence-specific DNA binding
D5285_17850	COG2267	carboxylic ester hydrolase activity
D5285_17865	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D5285_17880	COG5018	Exonuclease
D5285_17885	COG2814	Major facilitator Superfamily
D5285_17890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5285_17895	COG3011	Protein conserved in bacteria
D5285_17905	COG3290	protein histidine kinase activity
D5285_17910	COG4565	transcriptional regulatory protein
D5285_17920	COG1183	phosphatidylcholine synthase activity
D5285_17925	COG0586	Pfam SNARE associated Golgi protein
D5285_17930	COG0688	phosphatidylethanolamine metabolic process
D5285_17935	COG3493	citrate carrier protein
D5285_17945	COG2111	Na H antiporter
D5285_17945	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D5285_17950	COG2111	Na H antiporter
D5285_17955	COG1006	Multisubunit Na H antiporter MnhC subunit
D5285_17960	COG0651	ATP synthesis coupled electron transport
D5285_17965	COG1863	multisubunit Na H antiporter MnhE subunit
D5285_17970	COG2212	antiporter activity
D5285_17975	COG1320	monovalent cation:proton antiporter activity
D5285_17980	COG2050	protein possibly involved in aromatic compounds catabolism
D5285_17985	COG2197	response regulator
D5285_17990	COG4585	Histidine kinase
D5285_18025	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D5285_18030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D5285_18035	COG1335	isochorismatase
D5285_18040	COG5506	Protein of unknown function (DUF1694)
D5285_18055	COG0628	permease
D5285_18060	COG1959	2 iron, 2 sulfur cluster binding
D5285_18075	COG1418	mRNA catabolic process
D5285_18080	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_18095	COG1511	domain protein
D5285_18100	COG1674	ftsk spoiiie
D5285_18100	COG0433	COG0433 Predicted ATPase
D5285_18105	COG4499	WXG100 protein secretion system (Wss), protein YukC
D5285_18110	COG5417	Belongs to the EsaB family
D5285_18115	COG4842	Belongs to the WXG100 family
D5285_18120	COG1115	amino acid carrier protein
D5285_18125	COG2508	Transcriptional regulator
D5285_18125	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D5285_18130	COG0686	Belongs to the AlaDH PNT family
D5285_18140	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D5285_18145	COG1268	BioY protein
D5285_18150	COG2056	Na+-H+ antiporter family
D5285_18155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D5285_18160	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D5285_18165	COG3584	3D domain protein
D5285_18175	COG1252	NADH dehydrogenase
D5285_18180	COG0492	ferredoxin-NADP+ reductase activity
D5285_18195	COG0454	-acetyltransferase
D5285_18200	COG0316	Belongs to the HesB IscA family
D5285_18205	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D5285_18210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5285_18215	COG4844	belongs to the
D5285_18220	COG1252	NADH dehydrogenase
D5285_18225	COG2323	membrane
D5285_18230	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D5285_18235	COG5646	InterPro IPR014922
D5285_18250	COG0457	Tetratricopeptide repeat
D5285_18255	COG3479	Phenolic acid decarboxylase
D5285_18265	COG4837	Protein of unknown function (DUF1462)
D5285_18270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D5285_18275	COG1506	peptidase
D5285_18275	COG0823	Involved in the tonB-independent uptake of proteins
D5285_18275	COG4946	Tricorn protease homolog
D5285_18280	COG0083	homoserine kinase activity
D5285_18285	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D5285_18290	COG0460	homoserine dehydrogenase
D5285_18295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5285_18300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D5285_18305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D5285_18310	COG0647	UMP catabolic process
D5285_18315	COG2445	Protein of unknown function DUF86
D5285_18320	COG4470	Protein conserved in bacteria
D5285_18335	COG0739	heme binding
D5285_18345	COG0733	neurotransmitter:sodium symporter activity
D5285_18355	COG3377	Domain of unknown function (DUF1805)
D5285_18360	COG0737	Belongs to the 5'-nucleotidase family
D5285_18365	COG0730	response to heat
D5285_18370	COG1801	Protein of unknown function DUF72
D5285_18380	COG3226	Transcriptional regulator
D5285_18385	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D5285_18390	COG2508	Transcriptional regulator
D5285_18395	COG2814	Major facilitator Superfamily
D5285_18400	COG1288	antiporter activity
D5285_18415	COG2356	endonuclease I
D5285_18425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D5285_18440	COG0457	Tetratricopeptide repeat
D5285_18450	COG0719	Fe-S assembly protein
D5285_18455	COG0822	iron-sulfur transferase activity
D5285_18460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5285_18465	COG0719	Fe-S assembly protein
D5285_18470	COG0396	ATPase activity
D5285_18480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5285_18485	COG1464	Belongs to the NlpA lipoprotein family
D5285_18490	COG2011	ABC-type metal ion transport system permease component
D5285_18495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D5285_18505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D5285_18510	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D5285_18520	COG0509	glycine decarboxylation via glycine cleavage system
D5285_18525	COG1393	Belongs to the ArsC family
D5285_18530	COG1960	acyl-CoA dehydrogenase activity
D5285_18535	COG0183	Belongs to the thiolase family
D5285_18540	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5285_18540	COG1024	Enoyl-CoA hydratase
D5285_18555	COG5577	PFAM Coat F domain
D5285_18570	COG1120	ATPase activity
D5285_18575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_18580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_18585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_18600	COG1686	Belongs to the peptidase S11 family
D5285_18605	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_18610	COG0783	Belongs to the Dps family
D5285_18620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5285_18625	COG0745	RESPONSE REGULATOR receiver
D5285_18630	COG2770	Histidine kinase
D5285_18630	COG2205	protein histidine kinase activity
D5285_18635	COG1309	transcriptional regulator
D5285_18640	COG0114	fumarate hydratase activity
D5285_18650	COG0697	spore germination
D5285_18655	COG0814	amino acid
D5285_18670	COG2197	response regulator
D5285_18675	COG4585	Histidine kinase
D5285_18680	COG4758	membrane
D5285_18690	COG1842	Phage shock protein A
D5285_18695	COG4758	membrane
D5285_18700	COG4677	pectinesterase activity
D5285_18705	COG2096	Adenosyltransferase
D5285_18710	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_18730	COG1454	alcohol dehydrogenase
D5285_18735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5285_18740	COG1120	ATPase activity
D5285_18745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_18750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_18755	COG1802	Transcriptional regulator
D5285_18760	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_18765	COG2258	MOSC domain
D5285_18770	COG0583	DNA-binding transcription factor activity
D5285_18780	COG2721	sulfolactate sulfo-lyase activity
D5285_18785	COG0246	Mannitol dehydrogenase
D5285_18790	COG1609	Transcriptional regulator
D5285_18795	COG2211	Major facilitator Superfamily
D5285_18800	COG1904	glucuronate isomerase
D5285_18805	COG2205	protein histidine kinase activity
D5285_18810	COG0745	RESPONSE REGULATOR receiver
D5285_18815	COG1120	ATPase activity
D5285_18820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_18825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_18830	COG0531	amino acid
D5285_18840	COG1988	membrane-bound metal-dependent
D5285_18845	COG1368	sulfuric ester hydrolase activity
D5285_18850	COG2814	Major facilitator Superfamily
D5285_18855	COG0656	L-ascorbic acid biosynthetic process
D5285_18860	COG1940	carbohydrate kinase activity
D5285_18865	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D5285_18875	COG0596	Alpha beta hydrolase
D5285_18880	COG3973	AAA domain
D5285_18885	COG2860	membrane
D5285_18890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D5285_18890	COG0456	acetyltransferase
D5285_18895	COG0456	acetyltransferase
D5285_18900	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D5285_18905	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D5285_18910	COG2217	Heavy metal translocating P-type atpase
D5285_18915	COG1653	transport
D5285_18920	COG1175	transmembrane transport
D5285_18925	COG0395	ABC-type sugar transport system, permease component
D5285_18930	COG1501	Belongs to the glycosyl hydrolase 31 family
D5285_18935	COG1472	Belongs to the glycosyl hydrolase 3 family
D5285_18940	COG1121	(ABC) transporter
D5285_18945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D5285_18950	COG0803	Belongs to the bacterial solute-binding protein 9 family
D5285_18970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5285_18970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_18970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D5285_18975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_18985	COG2217	Heavy metal translocating P-type atpase
D5285_18990	COG2608	mercury ion transmembrane transporter activity
D5285_18995	COG1937	Protein conserved in bacteria
D5285_19000	COG0693	protein deglycase activity
D5285_19005	COG1349	DNA-binding transcription factor activity
D5285_19010	COG1070	Carbohydrate kinase
D5285_19015	COG4952	isomerase
D5285_19025	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_19025	COG3347	Dehydrogenase
D5285_19030	COG2814	Major facilitator Superfamily
D5285_19035	COG2814	Major facilitator Superfamily
D5285_19045	COG2124	cytochrome p450
D5285_19055	COG1846	Transcriptional regulator
D5285_19065	COG0673	inositol 2-dehydrogenase activity
D5285_19070	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D5285_19085	COG1191	sigma factor activity
D5285_19095	COG2140	Oxalate decarboxylase
D5285_19115	COG5520	Belongs to the glycosyl hydrolase 30 family
D5285_19120	COG3507	Belongs to the glycosyl hydrolase 43 family
D5285_19135	COG5444	nuclease activity
D5285_19155	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D5285_19160	COG0557	exoribonuclease II activity
D5285_19165	COG1647	Serine aminopeptidase, S33
D5285_19170	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D5285_19175	COG2002	toxin-antitoxin pair type II binding
D5285_19180	COG1476	TRANSCRIPTIONal
D5285_19185	COG1396	sequence-specific DNA binding
D5285_19190	COG1396	sequence-specific DNA binding
D5285_19195	COG1174	glycine betaine transport
D5285_19200	COG1732	Glycine betaine
D5285_19205	COG1174	glycine betaine transport
D5285_19210	COG1125	glycine betaine transport
D5285_19210	COG0517	IMP dehydrogenase activity
D5285_19215	COG1510	regulation of RNA biosynthetic process
D5285_19220	COG2095	MarC family integral membrane protein
D5285_19225	COG3064	Membrane
D5285_19230	COG4640	response to antibiotic
D5285_19235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_19255	COG0693	protein deglycase activity
D5285_19260	COG0148	phosphopyruvate hydratase activity
D5285_19265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D5285_19270	COG0149	triose-phosphate isomerase activity
D5285_19275	COG0126	phosphoglycerate kinase activity
D5285_19285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D5285_19290	COG2390	Transcriptional regulator
D5285_19295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5285_19300	COG1113	amino acid transport
D5285_19325	COG1556	Lactate utilization protein
D5285_19330	COG1139	Iron-sulfur cluster binding protein
D5285_19335	COG0247	lactate metabolic process
D5285_19340	COG2186	Transcriptional regulator
D5285_19345	COG1620	l-lactate permease
D5285_19350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D5285_19360	COG5039	Polysaccharide pyruvyl transferase
D5285_19365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5285_19370	COG0110	maltose O-acetyltransferase activity
D5285_19390	COG1216	Glycosyl transferase, family 2
D5285_19395	COG5039	Polysaccharide pyruvyl transferase
D5285_19400	COG1216	Glycosyl transferase, family 2
D5285_19410	COG0438	transferase activity, transferring glycosyl groups
D5285_19415	COG1215	transferase activity, transferring glycosyl groups
D5285_19420	COG0438	transferase activity, transferring glycosyl groups
D5285_19425	COG1086	Polysaccharide biosynthesis protein
D5285_19430	COG0489	protein tyrosine kinase activity
D5285_19435	COG3944	biosynthesis protein
D5285_19440	COG1396	sequence-specific DNA binding
D5285_19445	COG2249	NAD(P)H dehydrogenase (quinone) activity
D5285_19450	COG2271	Major facilitator Superfamily
D5285_19460	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D5285_19470	COG1454	alcohol dehydrogenase
D5285_19475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D5285_19485	COG1733	regulation of RNA biosynthetic process
D5285_19490	COG1902	pentaerythritol trinitrate reductase activity
D5285_19495	COG1621	beta-fructofuranosidase activity
D5285_19500	COG1621	beta-fructofuranosidase activity
D5285_19515	COG0740	serine-type endopeptidase activity
D5285_19520	COG1611	Belongs to the LOG family
D5285_19525	COG1694	Mazg nucleotide pyrophosphohydrolase
D5285_19530	COG1078	dGTPase activity
D5285_19535	COG0659	secondary active sulfate transmembrane transporter activity
D5285_19540	COG0288	reversible hydration of carbon dioxide
D5285_19545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5285_19550	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D5285_19555	COG0640	Transcriptional regulator
D5285_19565	COG2732	(Barnase) inhibitor
D5285_19570	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D5285_19575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_19580	COG1481	regulation of sporulation
D5285_19585	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D5285_19590	COG1660	Displays ATPase and GTPase activities
D5285_19595	COG1051	belongs to the nudix hydrolase family
D5285_19605	COG0492	ferredoxin-NADP+ reductase activity
D5285_19610	COG0457	Tetratricopeptide repeat
D5285_19615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5285_19620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D5285_19620	COG0140	phosphoribosyl-ATP diphosphatase activity
D5285_19625	COG0107	imidazoleglycerol-phosphate synthase activity
D5285_19630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D5285_19635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D5285_19640	COG0131	Imidazoleglycerol-phosphate dehydratase
D5285_19645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D5285_19650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D5285_19655	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D5285_19660	COG4990	cell redox homeostasis
D5285_19665	COG5297	Belongs to the glycosyl hydrolase family 6
D5285_19670	COG0110	maltose O-acetyltransferase activity
D5285_19675	COG0546	phosphoglycolate phosphatase activity
D5285_19680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D5285_19685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D5285_19690	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D5285_19695	COG1846	Transcriptional regulator
D5285_19700	COG2814	Major facilitator Superfamily
D5285_19705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D5285_19710	COG1950	PFAM Membrane protein of
D5285_19715	COG1983	PspC domain protein
D5285_19720	COG3595	metallopeptidase activity
D5285_19740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D5285_19745	COG0556	nucleotide-excision repair
D5285_19750	COG4897	Protein conserved in bacteria
D5285_19760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5285_19770	COG3409	Peptidoglycan-binding domain 1 protein
D5285_19770	COG0793	Belongs to the peptidase S41A family
D5285_19775	COG0473	3-isopropylmalate dehydrogenase activity
D5285_19780	COG3883	PFAM NLP P60 protein
D5285_19780	COG0791	NLP P60 protein
D5285_19785	COG2177	Part of the ABC transporter FtsEX involved in
D5285_19790	COG2884	Cell division ATP-binding protein ftsE
D5285_19800	COG2010	Cytochrome c
D5285_19805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_19815	COG0653	protein targeting
D5285_19820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D5285_19835	COG1516	flagellar protein fliS
D5285_19840	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D5285_19845	COG1334	flagellar protein FlaG
D5285_19855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5285_19860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D5285_19865	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D5285_19875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D5285_19880	COG1256	bacterial-type flagellum assembly
D5285_19880	COG4786	Flagellar basal body rod
D5285_19885	COG3418	PFAM FlgN family protein
D5285_19890	COG2747	anti-sigma28 factor FlgM
D5285_19900	COG1040	competence protein
D5285_19910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D5285_19915	COG1307	EDD domain protein, DegV family
D5285_19920	COG2197	response regulator
D5285_19925	COG4585	Histidine kinase
D5285_19930	COG1739	Uncharacterized protein family UPF0029
D5285_19935	COG1316	TRANSCRIPTIONal
D5285_19945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D5285_19950	COG0438	transferase activity, transferring glycosyl groups
D5285_19955	COG1215	transferase activity, transferring glycosyl groups
D5285_19960	COG3206	protein involved in exopolysaccharide biosynthesis
D5285_19965	COG3307	-O-antigen
D5285_19970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D5285_19975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D5285_19980	COG0297	glycogen (starch) synthase activity
D5285_19980	COG0438	transferase activity, transferring glycosyl groups
D5285_19985	COG2244	polysaccharide biosynthetic process
D5285_19995	COG2247	cell wall binding repeat
D5285_19995	COG0860	N-Acetylmuramoyl-L-alanine amidase
D5285_20000	COG2247	cell wall binding repeat
D5285_20000	COG2385	sporulation resulting in formation of a cellular spore
D5285_20010	COG1316	TRANSCRIPTIONal
D5285_20020	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D5285_20025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D5285_20045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5285_20065	COG1134	teichoic acid transport
D5285_20070	COG1682	transport, permease protein
D5285_20075	COG0463	Glycosyl transferase, family 2
D5285_20075	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5285_20080	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5285_20085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D5285_20090	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D5285_20095	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D5285_20100	COG4193	domain, Protein
D5285_20105	COG1482	cell wall glycoprotein biosynthetic process
D5285_20125	COG0800	Aldolase
D5285_20130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5285_20135	COG1609	Transcriptional regulator
D5285_20140	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D5285_20145	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_20150	COG1063	alcohol dehydrogenase
D5285_20155	COG2814	Major facilitator Superfamily
D5285_20160	COG1316	TRANSCRIPTIONal
D5285_20165	COG0561	phosphatase activity
D5285_20170	COG0791	NLP P60 protein
D5285_20175	COG2843	Capsule synthesis protein
D5285_20185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D5285_20190	COG1609	Transcriptional regulator
D5285_20195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5285_20200	COG1869	D-ribose catabolic process
D5285_20205	COG1129	ABC transporter
D5285_20210	COG1172	Belongs to the binding-protein-dependent transport system permease family
D5285_20215	COG1879	ABC-type sugar transport system periplasmic component
D5285_20220	COG0583	DNA-binding transcription factor activity
D5285_20225	COG2226	methyltransferase
D5285_20230	COG3527	Alpha-acetolactate decarboxylase
D5285_20235	COG0028	Belongs to the TPP enzyme family
D5285_20240	COG0583	DNA-binding transcription factor activity
D5285_20245	COG0405	Gamma-glutamyltransferase
D5285_20250	COG1522	sequence-specific DNA binding
D5285_20255	COG2059	Chromate
D5285_20260	COG2059	Chromate
D5285_20265	COG4464	protein tyrosine phosphatase activity
D5285_20270	COG3944	biosynthesis protein
D5285_20280	COG4715	Zinc finger, swim domain protein
D5285_20285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D5285_20295	COG3878	Protein conserved in bacteria
D5285_20300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D5285_20315	COG0561	phosphatase activity
D5285_20320	COG1349	DNA-binding transcription factor activity
D5285_20330	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_20340	COG3732	PTS system glucitol sorbitol-specific
D5285_20360	COG0629	single-stranded DNA binding
D5285_20375	COG1970	mechanosensitive ion channel activity
D5285_20380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D5285_20385	COG4786	Flagellar basal body rod
D5285_20390	COG4786	Flagellar basal body rod
D5285_20395	COG1077	Cell shape determining protein MreB Mrl
D5285_20400	COG1609	Transcriptional regulator
D5285_20410	COG1846	Transcriptional regulator
D5285_20415	COG2814	Major facilitator Superfamily
D5285_20420	COG0671	phosphoesterase, PA-phosphatase related
D5285_20425	COG1227	inorganic diphosphatase activity
D5285_20430	COG3546	catalase activity
D5285_20435	COG3361	conserved protein (COG2071)
D5285_20450	COG0517	IMP dehydrogenase activity
D5285_20455	COG0598	Magnesium transport protein CorA
D5285_20460	COG1253	flavin adenine dinucleotide binding
D5285_20470	COG0347	Belongs to the P(II) protein family
D5285_20480	COG0740	serine-type endopeptidase activity
D5285_20490	COG0739	heme binding
D5285_20495	COG1247	-acetyltransferase
D5285_20505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5285_20510	COG0477	Major facilitator Superfamily
D5285_20515	COG3251	PFAM MbtH domain protein
D5285_20520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_20525	COG1535	isochorismatase
D5285_20525	COG3433	isochorismatase activity
D5285_20530	COG1021	2,3-dihydroxybenzoate-AMP ligase
D5285_20535	COG1169	isochorismate synthase
D5285_20540	COG1028	Short-chain dehydrogenase reductase Sdr
D5285_20545	COG2819	hydrolase of the alpha beta superfamily
D5285_20550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_20555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_20560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_20565	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_20565	COG2207	Transcriptional regulator
D5285_20580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D5285_20590	COG1959	2 iron, 2 sulfur cluster binding
D5285_20600	COG1994	Peptidase M50
D5285_20605	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D5285_20610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D5285_20620	COG3383	formate dehydrogenase (NAD+) activity
D5285_20625	COG2304	oxidoreductase activity
D5285_20630	COG2304	oxidoreductase activity
D5285_20635	COG2385	sporulation resulting in formation of a cellular spore
D5285_20640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5285_20650	COG4836	Membrane
D5285_20655	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D5285_20660	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D5285_20665	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D5285_20670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D5285_20675	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5285_20680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D5285_20685	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D5285_20690	COG0356	it plays a direct role in the translocation of protons across the membrane
D5285_20705	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D5285_20710	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D5285_20715	COG4475	Protein of unknown function (DUF436)
D5285_20720	COG0698	ribose 5-phosphate isomerase
D5285_20725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D5285_20730	COG1971	Probably functions as a manganese efflux pump
D5285_20735	COG0009	L-threonylcarbamoyladenylate synthase
D5285_20740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D5285_20750	COG0738	Major facilitator superfamily
D5285_20755	COG0673	inositol 2-dehydrogenase activity
D5285_20760	COG0561	phosphatase activity
D5285_20765	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D5285_20770	COG1609	Transcriptional regulator
D5285_20780	COG2890	protein-(glutamine-N5) methyltransferase activity
D5285_20785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D5285_20790	COG0346	lactoylglutathione lyase activity
D5285_20795	COG0789	Transcriptional regulator
D5285_20800	COG0679	Auxin Efflux Carrier
D5285_20805	COG0281	malic enzyme
D5285_20810	COG1435	thymidine kinase activity
D5285_20815	COG0254	rRNA binding
D5285_20820	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D5285_20825	COG1494	fructose-1,6-bisphosphatase
D5285_20830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D5285_20835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D5285_20840	COG0191	fructose-bisphosphate aldolase activity
D5285_20845	COG2204	response regulator
D5285_20850	COG4821	SIS domain
D5285_20855	COG0504	CTP synthase activity
D5285_20860	COG3343	RNA polymerase activity
D5285_20865	COG1960	acyl-CoA dehydrogenase activity
D5285_20870	COG1960	acyl-CoA dehydrogenase activity
D5285_20875	COG1250	3-hydroxyacyl-CoA dehydrogenase
D5285_20880	COG0183	Belongs to the thiolase family
D5285_20885	COG0247	lactate metabolic process
D5285_20885	COG2181	nitrate reductase activity
D5285_20890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D5285_20900	COG0018	arginyl-trna synthetase
D5285_20905	COG4506	Protein conserved in bacteria
D5285_20910	COG0010	Belongs to the arginase family
D5285_20915	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D5285_20920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D5285_20930	COG1994	Peptidase M50
D5285_20935	COG1942	4-Oxalocrotonate Tautomerase
D5285_20945	COG3465	dGTPase activity
D5285_20950	COG1078	dGTPase activity
D5285_20955	COG4844	belongs to the
D5285_20980	COG2814	Major facilitator Superfamily
D5285_21005	COG1414	Transcriptional regulator
D5285_21015	COG0280	phosphate acetyltransferase
D5285_21035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D5285_21055	COG1131	(ABC) transporter
D5285_21095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5285_21100	COG0463	Glycosyl transferase, family 2
D5285_21105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D5285_21110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D5285_21125	COG1609	Transcriptional regulator
D5285_21135	COG1175	transmembrane transport
D5285_21140	COG0395	ABC-type sugar transport system, permease component
D5285_21145	COG2223	nitrite transmembrane transporter activity
D5285_21160	COG2195	Cleaves the N-terminal amino acid of tripeptides
D5285_21170	COG1595	DNA-templated transcription, initiation
D5285_21180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_21185	COG2723	6-phospho-beta-galactosidase activity
D5285_21195	COG0549	Belongs to the carbamate kinase family
D5285_21205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D5285_21210	COG2235	arginine
D5285_21230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D5285_21240	COG1368	sulfuric ester hydrolase activity
D5285_21255	COG0584	glycerophosphoryl diester phosphodiesterase
D5285_21260	COG3493	citrate carrier protein
D5285_21265	COG1215	transferase activity, transferring glycosyl groups
D5285_21275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D5285_21280	COG0726	polysaccharide deacetylase
D5285_21295	COG5294	Protein conserved in bacteria
D5285_21300	COG0577	efflux transmembrane transporter activity
D5285_21305	COG1136	(ABC) transporter
D5285_21310	COG2205	protein histidine kinase activity
D5285_21315	COG0745	RESPONSE REGULATOR receiver
D5285_21320	COG2706	6-phosphogluconolactonase activity
D5285_21325	COG1396	sequence-specific DNA binding
D5285_21330	COG0252	asparaginase activity
D5285_21335	COG1027	Aspartate ammonia-lyase
D5285_21340	COG1757	Na H antiporter
D5285_21345	COG0281	malic enzyme
D5285_21355	COG2116	formate transmembrane transporter activity
D5285_21365	COG1271	oxidase subunit
D5285_21370	COG1294	oxidase, subunit
D5285_21375	COG4988	ABC transporter
D5285_21380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D5285_21385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D5285_21390	COG3866	Pectate lyase
D5285_21400	COG0735	belongs to the Fur family
D5285_21405	COG0753	catalase activity
D5285_21410	COG0753	catalase activity
D5285_21420	COG2814	Major facilitator Superfamily
D5285_21425	COG1595	DNA-templated transcription, initiation
D5285_21445	COG1131	(ABC) transporter
D5285_21450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D5285_21455	COG2814	Major facilitator Superfamily
D5285_21470	COG2755	lipolytic protein G-D-S-L family
D5285_21475	COG1132	(ABC) transporter
D5285_21490	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D5285_21495	COG2079	MmgE PrpD family protein
D5285_21500	COG0372	Belongs to the citrate synthase family
D5285_21510	COG2094	Belongs to the DNA glycosylase MPG family
D5285_21515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D5285_21515	COG3711	transcriptional antiterminator
D5285_21520	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_21525	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D5285_21530	COG1447	Phosphotransferase system cellobiose-specific component IIA
D5285_21535	COG1486	melibiose metabolic process
D5285_21540	COG2814	Major facilitator Superfamily
D5285_21545	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D5285_21550	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D5285_21555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D5285_21560	COG1696	Membrane protein involved in D-alanine export
D5285_21565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D5285_21580	COG2357	RelA SpoT domain protein
D5285_21595	COG0477	Major facilitator Superfamily
D5285_21600	COG2234	aminopeptidase activity
D5285_21610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5285_21615	COG0800	Aldolase
D5285_21620	COG4948	Mandelate Racemase Muconate Lactonizing
D5285_21625	COG2271	Major facilitator Superfamily
D5285_21630	COG5522	Integral membrane protein (intg_mem_TP0381)
D5285_21635	COG2409	Drug exporters of the RND superfamily
D5285_21640	COG2197	response regulator
D5285_21645	COG4585	Histidine kinase
D5285_21660	COG1442	glycosyl transferase family 8
D5285_21665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D5285_21670	COG0346	lactoylglutathione lyase activity
D5285_21675	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D5285_21680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5285_21690	COG1346	cytolysis
D5285_21695	COG1380	Effector of murein hydrolase LrgA
D5285_21710	COG0583	DNA-binding transcription factor activity
D5285_21715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D5285_21720	COG0352	thiamine-phosphate diphosphorylase activity
D5285_21725	COG1940	carbohydrate kinase activity
D5285_21730	COG2115	Belongs to the xylose isomerase family
D5285_21735	COG1070	Carbohydrate kinase
D5285_21740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D5285_21745	COG3162	membrane
D5285_21750	COG0655	NAD(P)H dehydrogenase (quinone) activity
D5285_21765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5285_21770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D5285_21775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D5285_21785	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D5285_21825	COG0456	acetyltransferase
D5285_21845	COG0772	Belongs to the SEDS family
D5285_21850	COG0772	Belongs to the SEDS family
D5285_21855	COG1473	amidohydrolase
D5285_21860	COG0778	Nitroreductase
D5285_21865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D5285_21875	COG1404	Belongs to the peptidase S8 family
D5285_21885	COG3711	transcriptional antiterminator
D5285_21890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_21890	COG1263	PTS System
D5285_21895	COG1621	beta-fructofuranosidase activity
D5285_21905	COG0351	phosphomethylpyrimidine kinase
D5285_21910	COG1216	Glycosyl transferase, family 2
D5285_21915	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D5285_21930	COG2363	Small membrane protein
D5285_21935	COG2233	PERMEase
D5285_21960	COG0753	catalase activity
D5285_21960	COG0693	protein deglycase activity
D5285_21970	COG2723	6-phospho-beta-galactosidase activity
D5285_21975	COG1263	PTS System
D5285_21975	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_21975	COG2190	(PTS) system
D5285_21980	COG3711	transcriptional antiterminator
D5285_21985	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D5285_21990	COG1122	ATPase activity
D5285_21995	COG4721	ABC-type cobalt transport system, permease component
D5285_22000	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D5285_22005	COG2224	Isocitrate lyase
D5285_22010	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D5285_22020	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D5285_22025	COG0577	efflux transmembrane transporter activity
D5285_22030	COG1136	(ABC) transporter
D5285_22035	COG2205	protein histidine kinase activity
D5285_22040	COG0745	RESPONSE REGULATOR receiver
D5285_22045	COG2723	6-phospho-beta-galactosidase activity
D5285_22050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_22050	COG2190	(PTS) system
D5285_22050	COG1263	PTS System
D5285_22060	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D5285_22065	COG3507	Belongs to the glycosyl hydrolase 43 family
D5285_22070	COG0513	Belongs to the DEAD box helicase family
D5285_22115	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D5285_22120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D5285_22125	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D5285_22130	COG2390	Transcriptional regulator
D5285_22135	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D5285_22140	COG3706	GGDEF domain
D5285_22145	COG5298	Protein conserved in bacteria
D5285_22150	COG1215	transferase activity, transferring glycosyl groups
D5285_22160	COG3977	Valine--pyruvate aminotransferase
D5285_22175	COG1181	Belongs to the D-alanine--D-alanine ligase family
D5285_22185	COG0191	fructose-bisphosphate aldolase activity
D5285_22190	COG1082	Xylose isomerase domain protein TIM barrel
D5285_22195	COG1082	Xylose isomerase domain protein TIM barrel
D5285_22200	COG0673	inositol 2-dehydrogenase activity
D5285_22205	COG2814	Major facilitator Superfamily
D5285_22210	COG1082	Xylose isomerase domain protein TIM barrel
D5285_22215	COG3962	Belongs to the TPP enzyme family
D5285_22220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D5285_22225	COG3718	enzyme involved in inositol metabolism
D5285_22230	COG1012	belongs to the aldehyde dehydrogenase family
D5285_22235	COG1349	DNA-binding transcription factor activity
D5285_22240	COG0667	Aldo Keto reductase
D5285_22245	COG0584	glycerophosphoryl diester phosphodiesterase
D5285_22250	COG2271	Major facilitator Superfamily
D5285_22255	COG0326	Molecular chaperone. Has ATPase activity
D5285_22260	COG0488	(ABC) transporter
D5285_22265	COG0561	phosphatase activity
D5285_22285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_22315	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D5285_22320	COG0577	efflux transmembrane transporter activity
D5285_22325	COG1136	(ABC) transporter
D5285_22330	COG2205	protein histidine kinase activity
D5285_22335	COG0745	RESPONSE REGULATOR receiver
D5285_22345	COG5278	phosphoserine phosphatase activity
D5285_22345	COG0840	transmembrane signaling receptor activity
D5285_22350	COG1115	amino acid carrier protein
D5285_22355	COG0686	Belongs to the AlaDH PNT family
D5285_22360	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D5285_22365	COG1874	Beta-galactosidase
D5285_22370	COG3833	ABC-type maltose transport systems, permease component
D5285_22375	COG1175	transmembrane transport
D5285_22380	COG2182	Extracellular solute-binding protein
D5285_22385	COG1609	Transcriptional regulator
D5285_22390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D5285_22395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D5285_22400	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D5285_22405	COG1940	carbohydrate kinase activity
D5285_22415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D5285_22445	COG1454	alcohol dehydrogenase
D5285_22445	COG1012	belongs to the aldehyde dehydrogenase family
D5285_22450	COG0450	alkyl hydroperoxide reductase
D5285_22455	COG3634	alkyl hydroperoxide reductase activity
D5285_22460	COG1113	amino acid transport
D5285_22480	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D5285_22505	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D5285_22510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_22515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D5285_22530	COG1131	(ABC) transporter
D5285_22535	COG0842	Transport permease protein
D5285_22540	COG4585	Histidine kinase
D5285_22545	COG2197	response regulator
D5285_22550	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D5285_22560	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D5285_22575	COG0456	acetyltransferase
D5285_22590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D5285_22595	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D5285_22600	COG4853	Protein conserved in bacteria
D5285_22605	COG4863	YycH protein
D5285_22610	COG5002	protein histidine kinase activity
D5285_22615	COG0745	RESPONSE REGULATOR receiver
D5285_22645	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D5285_22655	COG0305	Participates in initiation and elongation during chromosome replication
D5285_22670	COG3093	addiction module antidote protein HigA
D5285_22675	COG2807	transmembrane transport
D5285_22680	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D5285_22685	COG0363	glucosamine-6-phosphate deaminase activity
D5285_22695	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D5285_22700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D5285_22700	COG1263	PTS System
D5285_22705	COG0359	binds to the 23S rRNA
D5285_22710	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D5285_22715	COG4241	membrane
D5285_22720	COG5577	PFAM Coat F domain
D5285_22725	COG0589	response to stress
D5285_22730	COG0659	secondary active sulfate transmembrane transporter activity
D5285_22735	COG2271	Major facilitator Superfamily
D5285_22740	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D5285_22745	COG0629	single-stranded DNA binding
D5285_22750	COG0360	Binds together with S18 to 16S ribosomal RNA
D5285_22755	COG0012	GTP binding
D5285_22765	COG4481	Protein conserved in bacteria
D5285_22770	COG3949	Membrane
D5285_22780	COG1475	DNA binding
D5285_22785	COG1192	Involved in chromosome partitioning
D5285_22790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D5285_22795	COG1595	DNA-templated transcription, initiation
D5285_22800	COG1475	DNA binding
D5285_22805	COG0357	Ribosomal RNA small subunit methyltransferase G
D5285_22810	COG0445	tRNA wobble uridine modification
D5285_22815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D5285_22820	COG1847	R3H domain protein
D5285_22825	COG0706	membrane insertase activity
D5285_22830	COG0594	ribonuclease P activity
D5285_22835	COG0230	Belongs to the bacterial ribosomal protein bL34 family