locus-tag class description SC10_B2orf00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) SC10_B2orf00004 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) SC10_B2orf00005 ENOG410848D S4 domain protein YaaA SC10_B2orf00006 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) SC10_B2orf00010 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SC10_B2orf00016 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) SC10_B2orf00018 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) SC10_B2orf00019 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) SC10_B2orf00023 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) SC10_B2orf00025 ENOG4105BZW Glycerate kinase SC10_B2orf00026 ENOG4107QQ0 gntp family SC10_B2orf00027 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR SC10_B2orf00031 ENOG4105ZMH deoxynucleoside kinase SC10_B2orf00034 ENOG4105VRS hydrolase family 18 SC10_B2orf00036 ENOG4105GTG Isochorismatase SC10_B2orf00037 ENOG4108Z6B deaminase SC10_B2orf00038 ENOG4105C6E dna polymerase iii SC10_B2orf00040 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) SC10_B2orf00041 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) SC10_B2orf00044 ENOG41067KS pro-sigma K processing SC10_B2orf00050 ENOG4105CDW Resistance protein SC10_B2orf00051 ENOG4105CXN decarboxylase SC10_B2orf00052 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) SC10_B2orf00053 ENOG4105X0R protein from nitrogen regulatory protein P-II SC10_B2orf00054 ENOG4105XVJ Protein of unknown function (DUF327) SC10_B2orf00055 ENOG4105FA2 dna polymerase iii SC10_B2orf00056 ENOG4105MA4 psp1 domain protein SC10_B2orf00057 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) SC10_B2orf00058 ENOG41060K3 Methyltransferase SC10_B2orf00059 ENOG4105VC4 domain protein SC10_B2orf00060 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) SC10_B2orf00062 ENOG4105KRN Transcriptional regulator, abrb family SC10_B2orf00063 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) SC10_B2orf00064 ENOG4105F8V Hydrolase, tatD family SC10_B2orf00065 ENOG41069ER domain protein SC10_B2orf00067 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) SC10_B2orf00068 ENOG4105XFA sporulation peptidase YabG SC10_B2orf00069 ENOG4105W42 Veg protein SC10_B2orf00070 ENOG4105XEW small acid-soluble spore protein SC10_B2orf00072 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) SC10_B2orf00073 ENOG4105DFT pur operon repressor SC10_B2orf00074 ENOG4105KME endoribonuclease L-psp SC10_B2orf00075 ENOG4105K4W Could be involved in septation (By similarity) SC10_B2orf00076 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) SC10_B2orf00077 ENOG4105C5T Phosphoribosyl pyrophosphate synthase SC10_B2orf00078 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) SC10_B2orf00082 ENOG4108JA2 transcriptioN-repair coupling factor SC10_B2orf00083 ENOG4108M14 stage v sporulation protein t SC10_B2orf00088 ENOG4108IY2 MazG family SC10_B2orf00089 ENOG41082I2 s4 domain protein SC10_B2orf00091 ENOG4105VYY sporulation protein yabp SC10_B2orf00094 ENOG41060GV RNA binding s1 domain protein SC10_B2orf00101 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) SC10_B2orf00102 ENOG4108UGV hypoxanthine phosphoribosyltransferase SC10_B2orf00103 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) SC10_B2orf00106 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) SC10_B2orf00107 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) SC10_B2orf00109 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase SC10_B2orf00110 ENOG4105C6T cysteine synthase SC10_B2orf00111 ENOG4105CRQ synthase (Component I) SC10_B2orf00112 ENOG4105DDQ anthranilate synthase SC10_B2orf00113 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 SC10_B2orf00114 ENOG4105EEI dihydropteroate synthase SC10_B2orf00116 ENOG4105KRF dihydroneopterin aldolase SC10_B2orf00117 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase SC10_B2orf00118 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) SC10_B2orf00119 ENOG4105CRK lysyL-tRNA synthetase SC10_B2orf00125 ENOG4108Z0C Uvrb UvrC protein SC10_B2orf00126 ENOG41066A3 ATP guanido phosphotransferase SC10_B2orf00128 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) SC10_B2orf00129 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) SC10_B2orf00131 ENOG4105CTP PilT protein domain protein SC10_B2orf00132 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) SC10_B2orf00133 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) SC10_B2orf00134 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) SC10_B2orf00136 ENOG4105D7W serine acetyltransferase SC10_B2orf00138 ENOG4105C8N cysteinyl-tRNA synthetase SC10_B2orf00139 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) SC10_B2orf00140 ENOG4105C2N RNA methyltransferase TrmH family group 3 SC10_B2orf00141 ENOG4105M0M Tetracycline resistance protein SC10_B2orf00142 ENOG4105QIV RNA polymerase SC10_B2orf00144 ENOG410683Z Preprotein translocase SecE subunit SC10_B2orf00145 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) SC10_B2orf00147 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) SC10_B2orf00148 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) SC10_B2orf00149 ENOG4108VZM 50s ribosomal protein L10 SC10_B2orf00150 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) SC10_B2orf00151 ENOG4107Y49 methyltransferase SC10_B2orf00152 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SC10_B2orf00153 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SC10_B2orf00154 ENOG4105XPM ribosomal protein SC10_B2orf00155 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) SC10_B2orf00156 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) SC10_B2orf00157 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) SC10_B2orf00158 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) SC10_B2orf00159 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) SC10_B2orf00160 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) SC10_B2orf00161 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) SC10_B2orf00162 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity SC10_B2orf00164 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) SC10_B2orf00165 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) SC10_B2orf00166 ENOG41082SA 50s ribosomal protein l29 SC10_B2orf00168 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal SC10_B2orf00169 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) SC10_B2orf00170 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits SC10_B2orf00171 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) SC10_B2orf00172 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) SC10_B2orf00173 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) SC10_B2orf00174 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) SC10_B2orf00175 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) SC10_B2orf00176 ENOG4105VPB 50S ribosomal protein L30 SC10_B2orf00177 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) SC10_B2orf00178 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) SC10_B2orf00179 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) SC10_B2orf00180 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) SC10_B2orf00183 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits SC10_B2orf00184 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) SC10_B2orf00185 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) SC10_B2orf00186 ENOG4108ZT0 50S ribosomal protein l17 SC10_B2orf00187 ENOG4108JJB ABC transporter SC10_B2orf00188 ENOG4108JJB ABC transporter SC10_B2orf00190 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) SC10_B2orf00192 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) SC10_B2orf00193 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) SC10_B2orf00213 ENOG4108JJA ABC, transporter SC10_B2orf00219 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism SC10_B2orf00229 ENOG4105D1F ATP-binding protein SC10_B2orf00234 ENOG4108NMV polysaccharide deacetylase SC10_B2orf00237 ENOG4108A04 Beta-lactamase SC10_B2orf00241 ENOG4105JAB phenazine biosynthesis protein, phzf family SC10_B2orf00242 ENOG4105EHZ conserved protein UCP016719 SC10_B2orf00243 ENOG4105D17 glycoside hydrolase, family 3 domain protein SC10_B2orf00251 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate SC10_B2orf00254 ENOG4105EWC Purine nucleoside phosphorylase SC10_B2orf00257 ENOG4105EMN RNA polymerase sigma factor SC10_B2orf00259 ENOG4105C8B TIGR00159 family SC10_B2orf00260 ENOG4107U5W ybbr family SC10_B2orf00261 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) SC10_B2orf00264 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) SC10_B2orf00268 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family SC10_B2orf00270 ENOG4105WAB arsR family transcriptional regulator SC10_B2orf00271 ENOG4108RWP Major Facilitator Superfamily protein SC10_B2orf00273 ENOG4105BZ1 (ABC) transporter SC10_B2orf00274 ENOG4107ZXU DSBA oxidoreductase SC10_B2orf00283 ENOG41075D4 Aminoglycoside 6-adenylyltransferase SC10_B2orf00290 ENOG4105DUM transcriptional regulator, lysR family SC10_B2orf00291 ENOG4105E5W Transporter SC10_B2orf00292 ENOG4106DDH Sporulation-specific SASP protein SC10_B2orf00296 ENOG4105C7Z Conserved Protein SC10_B2orf00307 ENOG4105KRN Transcriptional regulator, abrb family SC10_B2orf00314 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) SC10_B2orf00316 ENOG4105DY8 decarboxylase SC10_B2orf00317 ENOG4108TVJ Nitroreductase SC10_B2orf00318 ENOG4105DRR Transcriptional regulator, GntR family SC10_B2orf00324 ENOG4107I77 yiaA/B two helix domain SC10_B2orf00332 ENOG410631K Membrane SC10_B2orf00334 ENOG4106AXJ AraC family transcriptional regulator SC10_B2orf00340 ENOG4107SCQ Iron-containing alcohol dehydrogenase SC10_B2orf00345 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid SC10_B2orf00349 ENOG4108IQI permease SC10_B2orf00350 ENOG4108J5H Homocysteine s-methyltransferase SC10_B2orf00354 ENOG4107TXC Transcriptional regulator SC10_B2orf00357 ENOG4108QY0 Membrane SC10_B2orf00365 ENOG4105CSV Glutaminase SC10_B2orf00369 ENOG4105KNA -acetyltransferase SC10_B2orf00372 ENOG4105NA0 Transcriptional regulator SC10_B2orf00375 ENOG4105DGI Alkaline phosphatase SC10_B2orf00376 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) SC10_B2orf00379 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) SC10_B2orf00381 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase SC10_B2orf00383 ENOG4105C26 Dehydrogenase SC10_B2orf00386 ENOG4105DJB Major Facilitator Superfamily SC10_B2orf00388 ENOG4105EQX glucarate dehydratase SC10_B2orf00390 ENOG41073TP transcriptional regulator SC10_B2orf00391 ENOG4105CTX dehydratase SC10_B2orf00395 ENOG4106FGC SC10_B2orf00398 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SC10_B2orf00404 ENOG4108R1P SC10_B2orf00406 ENOG4106K80 SC10_B2orf00409 ENOG41067TZ transcriptional regulator, MarR family SC10_B2orf00415 ENOG4107TXC Transcriptional regulator SC10_B2orf00422 ENOG4106UX7 integral membrane protein SC10_B2orf00426 ENOG41060AI SEC-C motif SC10_B2orf00428 ENOG4105DA5 (ABC) transporter SC10_B2orf00436 ENOG4108KSA LysR family transcriptional regulator SC10_B2orf00437 ENOG4105MDS 4-oxalocrotonate tautomerase SC10_B2orf00447 ENOG4107RB3 L-asparaginase SC10_B2orf00448 ENOG4108W0I acetyltransferase SC10_B2orf00451 ENOG4105DPN Oligoendopeptidase f SC10_B2orf00452 ENOG4107BMA Transglycosylase associated protein SC10_B2orf00455 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) SC10_B2orf00456 ENOG4105CQB FAD linked oxidase domain protein SC10_B2orf00458 ENOG4105VZJ PTS System SC10_B2orf00459 ENOG4105VCP PTS System SC10_B2orf00460 ENOG4105CK1 PTS System SC10_B2orf00462 ENOG4105F8D glycoside hydrolase family 4 SC10_B2orf00463 ENOG4108X79 transcriptional regulator SC10_B2orf00464 ENOG410901P UPF0249 protein SC10_B2orf00468 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases SC10_B2orf00470 ENOG4105H9W Short-chain dehydrogenase reductase Sdr SC10_B2orf00474 ENOG4105KHC sulfurtransferase SC10_B2orf00477 ENOG4105DEN Luciferase family SC10_B2orf00480 ENOG4105Z8B NlpC/P60 family SC10_B2orf00482 ENOG4105CIG ABC transporter SC10_B2orf00483 ENOG4108RZE Tetr family transcriptional regulator SC10_B2orf00490 ENOG4108N0M stress protein SC10_B2orf00492 ENOG4106FN3 tellurium resistance protein SC10_B2orf00493 ENOG4106FN3 tellurium resistance protein SC10_B2orf00495 ENOG4107TS3 membrane protein, TerC SC10_B2orf00498 ENOG4108TTB tellurium resistance protein SC10_B2orf00501 ENOG4107QIV Cytochrome c biogenesis protein SC10_B2orf00514 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) SC10_B2orf00516 ENOG410756H nucleotidyltransferase SC10_B2orf00522 ENOG4105C26 Dehydrogenase SC10_B2orf00523 ENOG4105CK7 Sodium proline symporter SC10_B2orf00526 ENOG4107YHD transcriptional regulator SC10_B2orf00528 ENOG4108PJD permease SC10_B2orf00531 ENOG4105I82 acetyl xylan esterase SC10_B2orf00537 ENOG4105E5Q amino acid AbC transporter SC10_B2orf00539 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein SC10_B2orf00540 ENOG4105NF4 modulator of drug activity SC10_B2orf00542 ENOG4105E2Y ABC, transporter SC10_B2orf00543 ENOG4105CS2 ec 3.2.1.21 SC10_B2orf00549 ENOG4105D9P serine threonine protein kinase SC10_B2orf00557 ENOG4105F38 ABC transporter, permease SC10_B2orf00558 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component SC10_B2orf00561 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf00567 ENOG4105SX7 Transporter SC10_B2orf00571 ENOG4105W8Z 4'-phosphopantetheinyl transferase SC10_B2orf00573 ENOG4108SA1 esterase SC10_B2orf00576 ENOG41086D8 Transcriptional regulator SC10_B2orf00584 ENOG4105CDA abc transporter atp-binding protein SC10_B2orf00586 ENOG4105DRP amino acid AbC transporter SC10_B2orf00590 ENOG4108JUB Transcriptional regulator SC10_B2orf00591 ENOG4105C8Y Acetylornithine aminotransferase SC10_B2orf00593 ENOG4108IQI permease SC10_B2orf00594 ENOG41066UZ arginase EC 3.5.3.1 SC10_B2orf00596 ENOG4106P55 Transcriptional regulator SC10_B2orf00597 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase SC10_B2orf00598 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) SC10_B2orf00599 ENOG41069ZX SC10_B2orf00600 ENOG41069ZX SC10_B2orf00622 ENOG4107EV6 Inherit from COG: YD repeat protein SC10_B2orf00628 ENOG4105C2F Histidine kinase SC10_B2orf00629 ENOG4105EQD regulatoR SC10_B2orf00631 ENOG4105DFW ABC transporter SC10_B2orf00634 ENOG4108HWW ABC transporter SC10_B2orf00636 ENOG4105DCM major facilitator superfamily SC10_B2orf00637 ENOG410645S MarR family Transcriptional regulator SC10_B2orf00640 ENOG4105C4C beta-galactosidase SC10_B2orf00642 ENOG4107T32 3-phytase (EC 3.1.3.8) SC10_B2orf00645 ENOG4105DUX Transporter SC10_B2orf00651 ENOG4105E1K spore germination protein SC10_B2orf00654 ENOG4107TXC Transcriptional regulator SC10_B2orf00659 ENOG4107WD8 ABC transporter, permease SC10_B2orf00660 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SC10_B2orf00661 ENOG4105BZU Histidine kinase SC10_B2orf00662 ENOG4105C8Q Methyl-accepting chemotaxis SC10_B2orf00665 ENOG4105CFH Aspartokinase SC10_B2orf00666 ENOG4105DHS permease protein SC10_B2orf00668 ENOG4105CM4 permease protein SC10_B2orf00669 ENOG4108IPW abc transporter atp-binding protein SC10_B2orf00675 ENOG4105R8C Transcriptional regulator SC10_B2orf00678 ENOG4108DBC nitroreductase SC10_B2orf00679 ENOG41067V3 Antibiotic biosynthesis monooxygenase SC10_B2orf00680 ENOG4105YVS arsR family transcriptional regulator SC10_B2orf00683 ENOG4108JPW Aminotransferase SC10_B2orf00685 ENOG4107QTZ amino acid SC10_B2orf00686 ENOG4105C26 Dehydrogenase SC10_B2orf00689 ENOG4108RNG Permease of the drug metabolite transporter SC10_B2orf00693 ENOG4105KTB nuclear export factor GLE1 SC10_B2orf00695 ENOG4108T5E Copper resistance protein SC10_B2orf00698 ENOG4108ZYE Transcriptional regulator SC10_B2orf00702 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) SC10_B2orf00703 ENOG4108IFG nitrite reductase, (NAD(P)H) SC10_B2orf00704 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit SC10_B2orf00707 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) SC10_B2orf00709 ENOG4105DRR Transcriptional regulator, GntR family SC10_B2orf00712 ENOG4105C8P )-transporter SC10_B2orf00716 ENOG4106ETB IIa component SC10_B2orf00722 ENOG4108IUS Transketolase SC10_B2orf00724 ENOG4105E7W lamb ycsf family protein SC10_B2orf00727 ENOG4105C5A transporter SC10_B2orf00729 ENOG4105CFM UPF0317 protein SC10_B2orf00731 ENOG4105P4J Allophanate hydrolase, subunit 1 SC10_B2orf00733 ENOG4107258 Transcriptional regulator SC10_B2orf00734 ENOG4105XJB lipolytic protein G-D-S-L family SC10_B2orf00738 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase SC10_B2orf00740 ENOG4105ETD TRANSCRIPTIONal SC10_B2orf00741 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SC10_B2orf00747 ENOG410606W general stress protein SC10_B2orf00751 ENOG4108RCF TRANSCRIPTIONal SC10_B2orf00752 ENOG4105VCH membrane SC10_B2orf00756 ENOG4105C9U ATP-dependent DNA helicase RecQ SC10_B2orf00763 ENOG4108M1A Chitin-binding protein SC10_B2orf00768 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) SC10_B2orf00769 ENOG4107BMA Transglycosylase associated protein SC10_B2orf00771 ENOG4108IJ0 Aspartate ammonia-lyase SC10_B2orf00774 ENOG41087PP glycosyltransferase MGT family SC10_B2orf00775 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) SC10_B2orf00777 ENOG4105EU9 SC10_B2orf00783 ENOG41082W1 Cupin 2, conserved barrel domain protein SC10_B2orf00786 ENOG4106F5Q Membrane SC10_B2orf00788 ENOG4105CK2 sodium dicarboxylate symporter SC10_B2orf00789 ENOG4105CJ1 ABC, transporter SC10_B2orf00793 ENOG4105FDT acyl-CoA dehydrogenase SC10_B2orf00800 ENOG4105SZ6 Thioredoxin SC10_B2orf00802 ENOG4105CPF Cell wall formation (By similarity) SC10_B2orf00804 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) SC10_B2orf00809 ENOG4105C1J atp-dependent rna helicase SC10_B2orf00811 ENOG410905X membrane-flanked domain protein SC10_B2orf00812 ENOG4105CKV Membrane SC10_B2orf00814 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein SC10_B2orf00817 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) SC10_B2orf00819 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) SC10_B2orf00820 ENOG4107MMM Anti-sigma-factor antagonist SC10_B2orf00821 ENOG4105FUA antagonist SC10_B2orf00822 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase SC10_B2orf00823 ENOG4107SGM protein serine threonine phosphatase SC10_B2orf00828 ENOG41064BQ Phosphatase SC10_B2orf00830 ENOG4105ST3 Transcriptional regulator SC10_B2orf00834 ENOG4105EYF MMPL domain protein SC10_B2orf00844 ENOG4105ECK Fatty Acid Desaturase SC10_B2orf00846 ENOG4105VEQ Cold shock protein SC10_B2orf00849 ENOG4107U9B transcriptional regulator SC10_B2orf00850 ENOG4105DXI Major Facilitator superfamily SC10_B2orf00853 ENOG4108U05 Transcriptional regulator SC10_B2orf00854 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 SC10_B2orf00858 ENOG4105KVH Transcriptional regulator SC10_B2orf00863 ENOG4105MJ9 esterase SC10_B2orf00864 ENOG4107Z6X Transcriptional regulator SC10_B2orf00869 ENOG4107XCH Cyclase family SC10_B2orf00882 ENOG4108VQT Alpha beta hydrolase fold protein SC10_B2orf00883 ENOG4105X5K response regulator receiver protein SC10_B2orf00885 ENOG4105JVQ RNA Polymerase SC10_B2orf00886 ENOG4108P49 AntiSigma factor SC10_B2orf00887 ENOG4105EXC Acyl-transferase SC10_B2orf00890 ENOG4105C2C drug resistance transporter, Bcr CflA SC10_B2orf00893 ENOG4108NEV two component transcriptional regulator, LytTR family SC10_B2orf00898 ENOG4108Z6X (sortase) family SC10_B2orf00900 ENOG4107QNK )-transporter SC10_B2orf00904 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) SC10_B2orf00905 ENOG4105K8N protein family UPF0079, ATPase SC10_B2orf00907 ENOG41072GX Peptidase M22 Glycoprotease SC10_B2orf00909 ENOG410801F ribosomal-protein-alanine acetyltransferase SC10_B2orf00910 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) SC10_B2orf00911 ENOG4105C5H ABC transporter SC10_B2orf00914 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) SC10_B2orf00915 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) SC10_B2orf00916 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) SC10_B2orf00919 ENOG4108TYN CAAX amino terminal protease family protein SC10_B2orf00920 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) SC10_B2orf00921 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) SC10_B2orf00922 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) SC10_B2orf00923 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) SC10_B2orf00949 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin SC10_B2orf00966 ENOG4108FKH Transglycosylase SLT domain SC10_B2orf00972 ENOG41068G1 SC10_B2orf00981 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) SC10_B2orf00988 ENOG41073R8 VanW family SC10_B2orf00993 ENOG4108RAV Conserved protein SC10_B2orf00996 ENOG4108X07 Tetr family transcriptional regulator SC10_B2orf00998 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) SC10_B2orf01002 ENOG4108VHC Short-chain dehydrogenase reductase Sdr SC10_B2orf01005 ENOG4105EBR Carboxylesterase SC10_B2orf01009 ENOG41087YS Phage shock protein A SC10_B2orf01010 ENOG4105DQX Zinc finger domain SC10_B2orf01011 ENOG4108WV1 Pfam:DUF477 SC10_B2orf01015 ENOG4108NGU Transcriptional regulator SC10_B2orf01016 ENOG4105N14 lysine exporter protein LysE YggA SC10_B2orf01022 ENOG4105CNI cell division protein FtsW SC10_B2orf01023 ENOG4105CNI cell division protein FtsW SC10_B2orf01030 ENOG4108ZJ4 polysaccharide deacetylase SC10_B2orf01031 ENOG4105E5K Alpha-amylase SC10_B2orf01032 ENOG4105FKQ transcriptional regulator SC10_B2orf01033 ENOG4108IUK alpha amylase, catalytic SC10_B2orf01035 ENOG4107FKK extracellular solute-binding protein family 1 SC10_B2orf01038 ENOG4105D56 permease protein SC10_B2orf01040 ENOG4105EG2 ABC transporter, permease SC10_B2orf01045 ENOG4105CG3 alpha amylase, catalytic region SC10_B2orf01047 ENOG4107URF beta-phospho-glucomutase SC10_B2orf01050 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) SC10_B2orf01051 ENOG4105GVJ transcriptional regulator SC10_B2orf01075 ENOG4108W3Q Transcriptional regulator SC10_B2orf01076 ENOG4107STQ Multicopper oxidase SC10_B2orf01082 ENOG4105C7R Atpase associated with various cellular activities aaa_3 SC10_B2orf01085 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) SC10_B2orf01088 ENOG4105C7N Xanthine uracil vitamin C permease SC10_B2orf01094 ENOG4108U5N UPF0316 protein SC10_B2orf01096 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) SC10_B2orf01097 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit SC10_B2orf01098 ENOG4105C83 adenylosuccinate lyase SC10_B2orf01099 ENOG4105C8V SAICAR synthetase SC10_B2orf01101 ENOG4105VR9 phosphoribosylformylglycinamidine synthase SC10_B2orf01103 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii SC10_B2orf01107 ENOG4105CXB phosphoribosylaminoimidazole synthetase SC10_B2orf01109 ENOG4108V3E phosphoribosylglycinamide formyltransferase SC10_B2orf01111 ENOG4105DC1 bifunctional purine biosynthesis protein purh SC10_B2orf01112 ENOG4105C12 Phosphoribosylglycinamide synthetase SC10_B2orf01115 ENOG4106A3M Cytochrome p-450 SC10_B2orf01127 ENOG4108R5T secreted protein SC10_B2orf01129 ENOG4105KGF protein, YerC YecD SC10_B2orf01132 ENOG4105C4R Atp-dependent dna helicase SC10_B2orf01135 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) SC10_B2orf01141 ENOG4108M21 SC10_B2orf01143 ENOG4105MUZ Protein of unknown function DUF2620 SC10_B2orf01146 ENOG4106M0N transport system permease protein SC10_B2orf01147 ENOG41080QX K07048 phosphotriesterase-related protein SC10_B2orf01148 ENOG4106PKC pyridoxal phosphate binding SC10_B2orf01149 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) SC10_B2orf01150 ENOG4108626 Racemase SC10_B2orf01152 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) SC10_B2orf01153 ENOG4105KT7 mgtC SapB transporter SC10_B2orf01155 ENOG4105CK7 Sodium proline symporter SC10_B2orf01156 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) SC10_B2orf01157 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) SC10_B2orf01158 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) SC10_B2orf01161 ENOG4105D3P Mannan endo-1,4-beta-mannosidase SC10_B2orf01162 ENOG4108IG5 Transcriptional regulator SC10_B2orf01170 ENOG4105D9U N-acetyltransferase SC10_B2orf01171 ENOG4105DU0 nucleoside hydrolase SC10_B2orf01173 ENOG4105CBD Diacylglycerol kinase SC10_B2orf01175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SC10_B2orf01176 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving SC10_B2orf01179 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SC10_B2orf01181 ENOG4105C5Y PTS System SC10_B2orf01182 ENOG4105CS2 ec 3.2.1.21 SC10_B2orf01183 ENOG4105CID antiterminator SC10_B2orf01184 ENOG410780I phosphoprotein phosphatase activity SC10_B2orf01189 ENOG4108HFV SC10_B2orf01193 ENOG4107Y9U Membrane SC10_B2orf01195 ENOG4108PCN EamA-like transporter family SC10_B2orf01196 ENOG4105CDY transcriptional regulatory protein SC10_B2orf01199 ENOG4105C26 Dehydrogenase SC10_B2orf01201 ENOG4105FKZ Methyl-accepting chemotaxis SC10_B2orf01203 ENOG4105XEA Tetr family transcriptional regulator SC10_B2orf01204 ENOG4105C8P )-transporter SC10_B2orf01205 ENOG4105C5H ABC transporter SC10_B2orf01207 ENOG4105DUM transcriptional regulator, lysR family SC10_B2orf01212 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) SC10_B2orf01214 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase SC10_B2orf01218 ENOG4105CKI cobalamin synthesis protein SC10_B2orf01220 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) SC10_B2orf01221 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SC10_B2orf01222 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) SC10_B2orf01223 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) SC10_B2orf01224 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) SC10_B2orf01226 ENOG4106A3M Cytochrome p-450 SC10_B2orf01228 ENOG4107SWG transcriptional regulator MERR family SC10_B2orf01230 ENOG4105DXB Major Facilitator superfamily SC10_B2orf01234 ENOG4105C5H ABC transporter SC10_B2orf01235 ENOG4105FDU atp-dependent rna helicase SC10_B2orf01239 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein SC10_B2orf01247 ENOG4107QPK )-transporter SC10_B2orf01259 ENOG4105VRS hydrolase family 18 SC10_B2orf01262 ENOG41082BM Transcriptional regulator, arsr family SC10_B2orf01264 ENOG410855V Acylphosphatase SC10_B2orf01265 ENOG4108RPX mosc domain containing protein SC10_B2orf01270 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) SC10_B2orf01278 ENOG4105C5Y PTS System SC10_B2orf01283 ENOG4107414 GntR family transcriptional regulator SC10_B2orf01300 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase SC10_B2orf01301 ENOG4105D7W serine acetyltransferase SC10_B2orf01302 ENOG4108IAJ Nad-dependent epimerase dehydratase SC10_B2orf01307 ENOG4107TVC Glycosyl transferase, family 2 SC10_B2orf01312 ENOG4107QQG Dehydrogenase SC10_B2orf01314 ENOG4105KVH Transcriptional regulator SC10_B2orf01315 ENOG4108RCM Nitroreductase SC10_B2orf01317 ENOG4105CGH 5'-nucleotidase SC10_B2orf01318 ENOG4107RKG DJ-1/PfpI family SC10_B2orf01321 ENOG4105BZG amino acid carrier protein SC10_B2orf01322 ENOG4105KJF protein tyrosine phosphatase SC10_B2orf01324 ENOG4107U9T Pfam:Ribonuclease_BN SC10_B2orf01327 ENOG4108ISG Major Facilitator SC10_B2orf01330 ENOG4105UPD Calcium Proton SC10_B2orf01342 ENOG4105DCT glycerol dehydrogenase SC10_B2orf01347 ENOG4105D7N magnesium and cobalt transport protein CorA SC10_B2orf01349 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) SC10_B2orf01366 ENOG41079KZ Major Facilitator Superfamily SC10_B2orf01374 ENOG4105EVH UPF0753 protein SC10_B2orf01375 ENOG4108TWJ NADH dehydrogenase subunit 5 SC10_B2orf01376 ENOG4105GPN Uncharacterized conserved protein (DUF2294) SC10_B2orf01381 ENOG4107RUY (E1 component), alpha subunit SC10_B2orf01384 ENOG4107QKR Dehydrogenase SC10_B2orf01387 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family SC10_B2orf01388 ENOG4105KK4 UPF0060 membrane protein SC10_B2orf01389 ENOG4105F8D glycoside hydrolase family 4 SC10_B2orf01390 ENOG4108Q3X Transcriptional regulator SC10_B2orf01391 ENOG4105CI1 PTS System SC10_B2orf01396 ENOG4105KVH Transcriptional regulator SC10_B2orf01398 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase SC10_B2orf01399 ENOG4105E4I Glycoside hydrolase family 28 SC10_B2orf01400 ENOG4105DSG hydrolase family 43 SC10_B2orf01402 ENOG4108DMH HTH_ARAC SC10_B2orf01405 ENOG4105DYS nad(p)h dehydrogenase (quinone) SC10_B2orf01411 ENOG4105JAB phenazine biosynthesis protein, phzf family SC10_B2orf01412 ENOG4107Y03 Nitroreductase SC10_B2orf01420 ENOG4105ECP epimerase SC10_B2orf01422 ENOG410691R Modulates RecA activity (By similarity) SC10_B2orf01433 ENOG4105CKK Glycosyl transferase, family 2 SC10_B2orf01435 ENOG4105EJV Membrane SC10_B2orf01437 ENOG41067AE Membrane-bound metal-dependent hydrolase SC10_B2orf01438 ENOG4105CEN a g-specific adenine glycosylase SC10_B2orf01439 ENOG4106BXE SC10_B2orf01442 ENOG4105CAN Short-chain dehydrogenase reductase Sdr SC10_B2orf01447 ENOG4105BZ1 (ABC) transporter SC10_B2orf01448 ENOG4105C3U ABC transporter SC10_B2orf01449 ENOG4108JQ7 (ABC) transporter SC10_B2orf01452 ENOG4105DEF Extracellular solute-binding protein, family 5 SC10_B2orf01454 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SC10_B2orf01455 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SC10_B2orf01457 ENOG4107NBY Membrane SC10_B2orf01459 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase SC10_B2orf01460 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SC10_B2orf01462 ENOG4105G5W regulator Fur family SC10_B2orf01463 ENOG4105TUA UPF0295 protein SC10_B2orf01506 ENOG4105CAR Terminase, large subunit SC10_B2orf01509 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) SC10_B2orf01519 ENOG4108FKH Transglycosylase SLT domain SC10_B2orf01521 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj SC10_B2orf01534 ENOG4107EV6 Inherit from COG: YD repeat protein SC10_B2orf01541 ENOG4105C22 threonyL-tRNA synthetase SC10_B2orf01549 ENOG4105FF2 Type I DHQase SC10_B2orf01551 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) SC10_B2orf01553 ENOG4105D7T ABC transporter SC10_B2orf01554 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein SC10_B2orf01556 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component SC10_B2orf01557 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) SC10_B2orf01559 ENOG4107D63 SC10_B2orf01560 ENOG4105VZ8 Transcriptional regulator SC10_B2orf01563 ENOG4105DA5 (ABC) transporter SC10_B2orf01568 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) SC10_B2orf01570 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) SC10_B2orf01572 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) SC10_B2orf01578 ENOG4105CYN Serine protein kinase SC10_B2orf01579 ENOG4106AKX UPF0229 protein SC10_B2orf01580 ENOG4105CW7 secretion protein, HlyD family SC10_B2orf01581 ENOG4105C0R drug resistance transporter emrb qaca subfamily SC10_B2orf01582 ENOG4105CS1 NAD(P)H quinone oxidoreductase SC10_B2orf01586 ENOG4105CZV ABC transporter SC10_B2orf01589 ENOG4105CJ1 ABC, transporter SC10_B2orf01591 ENOG4108TU7 Inherit from COG: (ABC) transporter SC10_B2orf01593 ENOG4105VEQ Cold shock protein SC10_B2orf01594 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) SC10_B2orf01595 ENOG4108UMI ABC transporter, permease SC10_B2orf01598 ENOG4107R6U sodium dicarboxylate symporter SC10_B2orf01612 ENOG4105BZU Histidine kinase SC10_B2orf01616 ENOG4108YBP pseudouridine synthase SC10_B2orf01619 ENOG41080XP Cbs domain SC10_B2orf01620 ENOG4107YBY Hydrolase SC10_B2orf01622 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase SC10_B2orf01626 ENOG4105C5H ABC transporter SC10_B2orf01627 ENOG4105TMB Formate nitrite transporter SC10_B2orf01633 ENOG4105CB2 alcohol dehydrogenase SC10_B2orf01634 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator SC10_B2orf01637 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) SC10_B2orf01638 ENOG4105C6V Glycerol-3-phosphate dehydrogenase SC10_B2orf01646 ENOG4105BZU Histidine kinase SC10_B2orf01648 ENOG4105WH1 Two component transcriptional regulator luxr family SC10_B2orf01653 ENOG4105KPV Transcriptional regulator SC10_B2orf01655 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) SC10_B2orf01657 ENOG4105ED1 spovr family SC10_B2orf01661 ENOG4105BZN citrate synthase SC10_B2orf01664 ENOG4105CYX Short-chain dehydrogenase reductase Sdr SC10_B2orf01667 ENOG4105C8J )-transporter SC10_B2orf01674 ENOG4107EV6 Inherit from COG: YD repeat protein SC10_B2orf01676 ENOG41086D8 Transcriptional regulator SC10_B2orf01678 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family SC10_B2orf01682 ENOG4105J37 SC10_B2orf01684 ENOG4108AEY RNA polymerase sigma factor SC10_B2orf01686 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein SC10_B2orf01687 ENOG4108FN7 Aldo keto reductase SC10_B2orf01688 ENOG4105F6E Acyl-transferase SC10_B2orf01689 ENOG4105KAF membrAne SC10_B2orf01692 ENOG4108IG5 Transcriptional regulator SC10_B2orf01694 ENOG4105C37 (CBS) domain SC10_B2orf01696 ENOG4105C37 (CBS) domain SC10_B2orf01707 ENOG4108QXE glycerophosphoryl diester phosphodiesterase SC10_B2orf01710 ENOG4105D64 Mechanosensitive ion channel SC10_B2orf01712 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) SC10_B2orf01716 ENOG4107VMI polysaccharide deacetylase SC10_B2orf01719 ENOG4105F0I Aminotransferase SC10_B2orf01723 ENOG4108N2V aldose 1-epimerase SC10_B2orf01733 ENOG4105BZ1 (ABC) transporter SC10_B2orf01734 ENOG4105BZ1 (ABC) transporter SC10_B2orf01746 ENOG410839P SC10_B2orf01748 ENOG4106MP8 UPF0754 membrane protein SC10_B2orf01749 ENOG4105WZB UPF0342 protein SC10_B2orf01753 ENOG4105D4P Coproporphyrinogen iii oxidase SC10_B2orf01756 ENOG4107S91 Sodium hydrogen exchanger SC10_B2orf01757 ENOG4105NCW Trka-c domain protein SC10_B2orf01759 ENOG4105CGU Enoyl-CoA hydratase SC10_B2orf01765 ENOG4108IUX (ABC) transporter SC10_B2orf01767 ENOG4105RHA ABC transporter, permease SC10_B2orf01769 ENOG4107VRP DNA repair exonuclease SC10_B2orf01770 ENOG4106D4I domain protein SC10_B2orf01771 ENOG4105EQI Metal Dependent Phosphohydrolase SC10_B2orf01774 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) SC10_B2orf01784 ENOG4105NBU tryptophan transport protein SC10_B2orf01785 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) SC10_B2orf01786 ENOG4105K59 histidine triad (HIT) protein SC10_B2orf01796 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation SC10_B2orf01797 ENOG4105BZ4 penicillin-binding protein SC10_B2orf01799 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) SC10_B2orf01800 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) SC10_B2orf01801 ENOG4105C1Q protoporphyrinogen oxidase SC10_B2orf01804 ENOG4105ECB domain protein SC10_B2orf01807 ENOG4105DER m42 family SC10_B2orf01812 ENOG4106AXD SC10_B2orf01814 ENOG4108RQ5 Beta-lactamase domain-containing protein SC10_B2orf01815 ENOG4105DF9 Lipoate-protein, ligase SC10_B2orf01816 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf01818 ENOG4108JCI Transcriptional regulator SC10_B2orf01822 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 SC10_B2orf01823 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin SC10_B2orf01824 ENOG4108UZ3 Transporter SC10_B2orf01826 ENOG4108HUF Transporter SC10_B2orf01828 ENOG4105DQ5 transport system permease protein SC10_B2orf01829 ENOG4108U1V ABC transporter, permease SC10_B2orf01831 ENOG4107TB6 phosphoglycerate mutase SC10_B2orf01833 ENOG4106YBV Methyl-accepting chemotaxis SC10_B2orf01838 ENOG4105XVF Competence transcription factor SC10_B2orf01839 ENOG41060YP SC10_B2orf01847 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin SC10_B2orf01849 ENOG4105G9B Transcriptional regulator SC10_B2orf01851 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) SC10_B2orf01854 ENOG4105CE7 Amidase, hydantoinase carbamoylase family SC10_B2orf01855 ENOG4105S0E allantoin catabolism protein SC10_B2orf01856 ENOG4105DG4 malate L-lactate dehydrogenase SC10_B2orf01857 ENOG4105DG4 malate L-lactate dehydrogenase SC10_B2orf01858 ENOG4107R1Q Membrane protein FdrA SC10_B2orf01859 ENOG4107REC cytoplasmic protein SC10_B2orf01861 ENOG4105G5A Protein of unknown function (DUF2877) SC10_B2orf01862 ENOG4105C5B carbamate kinase SC10_B2orf01863 ENOG4105CXY transporter SC10_B2orf01865 ENOG4107CUJ Protein of unknown function (DUF2690) SC10_B2orf01867 ENOG410780I phosphoprotein phosphatase activity SC10_B2orf01874 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component SC10_B2orf01875 ENOG4105I1K ABC transporter SC10_B2orf01877 ENOG4108KK1 membrane protein AbrB duplication SC10_B2orf01880 ENOG4105WEF catalase SC10_B2orf01882 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf01883 ENOG4106K7D Major facilitator family transporter SC10_B2orf01884 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) SC10_B2orf01887 ENOG4105BZU Histidine kinase SC10_B2orf01889 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SC10_B2orf01891 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein SC10_B2orf01892 ENOG4105E0C molybdate abc transporter SC10_B2orf01895 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation SC10_B2orf01900 ENOG4105EYH Exonuclease SC10_B2orf01908 ENOG410751J SC10_B2orf01914 ENOG4105ERH Fumarylacetoacetate hydrolase SC10_B2orf01923 ENOG4105CAQ asparagine synthetase SC10_B2orf01928 ENOG4108YZA Nitrogen regulatory protein pii SC10_B2orf01929 ENOG4105UQX Mate efflux family protein SC10_B2orf01930 ENOG4106HBX Transcriptional Regulator AraC Family SC10_B2orf01933 ENOG4105ETE Transcriptional regulator (LacI family SC10_B2orf01934 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) SC10_B2orf01940 ENOG4105E1K spore germination protein SC10_B2orf01942 ENOG4108ZUB Lysine exporter protein (Lyse ygga) SC10_B2orf01943 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family SC10_B2orf01945 ENOG4105DY8 decarboxylase SC10_B2orf01952 ENOG4105MA6 gCN5-related N-acetyltransferase SC10_B2orf01953 ENOG4105H9W Short-chain dehydrogenase reductase Sdr SC10_B2orf01956 ENOG4105D29 Helix-turn-helix type 11 domain protein SC10_B2orf01959 ENOG4108VPT UPF0234 protein SC10_B2orf01960 ENOG4105QNR S1 RNA binding domain protein SC10_B2orf01965 ENOG4105EPR degv family SC10_B2orf01967 ENOG4107AYK membrAne SC10_B2orf01971 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) SC10_B2orf01973 ENOG41073B9 SC10_B2orf01976 ENOG4108KP7 hydrolase SC10_B2orf01978 ENOG4108MXZ Esterase SC10_B2orf01979 ENOG4105VG1 fes assembly suf system protein SC10_B2orf01984 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase SC10_B2orf01986 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) SC10_B2orf01987 ENOG4105CAS nag kinase SC10_B2orf01988 ENOG4105C8Y Acetylornithine aminotransferase SC10_B2orf01989 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain SC10_B2orf01992 ENOG4105DBV ornithine carbamoyltransferase SC10_B2orf01993 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) SC10_B2orf02002 ENOG4107RMD Basic membrane lipoprotein SC10_B2orf02007 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) SC10_B2orf02008 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) SC10_B2orf02011 ENOG4105C3U ABC transporter SC10_B2orf02012 ENOG4108JQ7 (ABC) transporter SC10_B2orf02016 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SC10_B2orf02024 ENOG4105C31 Tryptophanyl-tRNA synthetase SC10_B2orf02027 ENOG4108J59 Extracellular solute-binding protein, family 5 SC10_B2orf02028 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SC10_B2orf02029 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SC10_B2orf02032 ENOG4108JQ7 (ABC) transporter SC10_B2orf02035 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) SC10_B2orf02036 ENOG4108ZCF integral membrane protein SC10_B2orf02037 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis SC10_B2orf02046 ENOG4108V9W transcriptional regulatory protein SC10_B2orf02047 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism SC10_B2orf02051 ENOG4105DPN Oligoendopeptidase f SC10_B2orf02053 ENOG4105T58 Dithiol-disulfide isomerase SC10_B2orf02054 ENOG4108Z18 K06886 hemoglobin SC10_B2orf02058 ENOG4105E4C Lytic transglycosylase catalytic SC10_B2orf02059 ENOG4105MIX Adenylate cyclase SC10_B2orf02060 ENOG4106EFP UPF0738 protein SC10_B2orf02062 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) SC10_B2orf02063 ENOG4105EMS pseudouridine synthase SC10_B2orf02064 ENOG4107S1Q Phosphatase SC10_B2orf02067 ENOG4105ETU transcriptional activator (TenA SC10_B2orf02068 ENOG4108VEU Thiamine monophosphate synthase SC10_B2orf02074 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) SC10_B2orf02076 ENOG4105D06 uba thif-type nad fad binding protein SC10_B2orf02077 ENOG4105DWF phosphomethylpyrimidine kinase SC10_B2orf02078 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH SC10_B2orf02079 ENOG4107A88 SC10_B2orf02095 ENOG4105ENA helicase SC10_B2orf02099 ENOG4107T5V SNARE associated Golgi SC10_B2orf02103 ENOG4105CMR udp-glucose 4-epimerase SC10_B2orf02104 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase SC10_B2orf02108 ENOG4108ZMI UPF0477 protein SC10_B2orf02117 ENOG4105C28 cystathionine SC10_B2orf02118 ENOG4105C28 cystathionine SC10_B2orf02120 ENOG4105JHY Membrane SC10_B2orf02123 ENOG4105FQP Beta-lactamase SC10_B2orf02126 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase SC10_B2orf02136 ENOG4108UW5 maltose o-acetyltransferase SC10_B2orf02142 ENOG4105DUM transcriptional regulator, lysR family SC10_B2orf02143 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) SC10_B2orf02145 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) SC10_B2orf02149 ENOG4108Q5Y Membrane SC10_B2orf02150 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase SC10_B2orf02155 ENOG41069ER domain protein SC10_B2orf02158 ENOG4105J7D transcriptional regulator SC10_B2orf02163 ENOG4105K7W phage-related replication protein SC10_B2orf02166 ENOG410635T phage-like element pbsx protein SC10_B2orf02182 ENOG4108TFU terminase (Small subunit) SC10_B2orf02184 ENOG4105IG6 Phage terminase, large subunit SC10_B2orf02185 ENOG4108MDF Phage Portal Protein SC10_B2orf02194 ENOG41060SN SC10_B2orf02198 ENOG4105PQS phage protein SC10_B2orf02199 ENOG4105FR7 XkdM protein, phage-like element PBSX SC10_B2orf02201 ENOG4105MTC XkdN-like protein SC10_B2orf02204 ENOG4108FKH Transglycosylase SLT domain SC10_B2orf02205 ENOG4108WZM domain protein SC10_B2orf02207 ENOG4105X7F SC10_B2orf02209 ENOG4105MFU Protein of unknown function (DUF2634) SC10_B2orf02210 ENOG41066EA baseplate J family protein SC10_B2orf02212 ENOG410906S phage-like element pbsx protein xkdt SC10_B2orf02219 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase SC10_B2orf02220 ENOG4107XBN GntR Family Transcriptional Regulator SC10_B2orf02221 ENOG4105CPQ Dehydrogenase SC10_B2orf02223 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) SC10_B2orf02225 ENOG4105DMW Dehydrogenase reductase SC10_B2orf02227 ENOG4105CPQ Dehydrogenase SC10_B2orf02230 ENOG4108I5G Major Facilitator superfamily SC10_B2orf02236 ENOG4105CJ3 phosphate transporter SC10_B2orf02237 ENOG4107GRR phosphate transport regulator SC10_B2orf02238 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) SC10_B2orf02241 ENOG4105C2F Histidine kinase SC10_B2orf02242 ENOG4105EQD regulatoR SC10_B2orf02246 ENOG410769Z extracellular solute-binding protein family 1 SC10_B2orf02247 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component SC10_B2orf02250 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component SC10_B2orf02253 ENOG4105F5H Glycosyl Hydrolase Family 88 SC10_B2orf02255 ENOG41075H3 AraC family transcriptional regulator SC10_B2orf02257 ENOG4107TDE lipolytic protein G-D-S-L family SC10_B2orf02264 ENOG4105CX8 fg-gap repeat protein SC10_B2orf02265 ENOG4107TDE lipolytic protein G-D-S-L family SC10_B2orf02268 ENOG4105CX8 fg-gap repeat protein SC10_B2orf02269 ENOG4105CPC Aldo Keto reductase SC10_B2orf02270 ENOG4107TDE lipolytic protein G-D-S-L family SC10_B2orf02274 ENOG4105EKC SC10_B2orf02276 ENOG4105E0S extracellular solute-binding protein family 1 SC10_B2orf02278 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component SC10_B2orf02279 ENOG4107R7I amino acid SC10_B2orf02282 ENOG4105C0H protease SC10_B2orf02288 ENOG4108ME1 Peptidase M55 D-aminopeptidase SC10_B2orf02289 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SC10_B2orf02291 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SC10_B2orf02293 ENOG4105C3U ABC transporter SC10_B2orf02296 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A SC10_B2orf02298 ENOG4105DTQ mandelate racemase muconate lactonizing SC10_B2orf02300 ENOG4107SN7 NLP P60 protein SC10_B2orf02301 ENOG4108JQ7 (ABC) transporter SC10_B2orf02303 ENOG4107TUM Amidinotransferase SC10_B2orf02304 ENOG4108S4H thioesterase Superfamily protein SC10_B2orf02309 ENOG4108J20 pectate lyase SC10_B2orf02320 ENOG410839T multidrug resistance protein SC10_B2orf02322 ENOG41080TC multidrug resistance protein SC10_B2orf02323 ENOG4105CIY formyltetrahydrofolate deformylase SC10_B2orf02326 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) SC10_B2orf02327 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) SC10_B2orf02331 ENOG4105K56 Transcriptional regulator SC10_B2orf02332 ENOG4108ZHJ Organic hydroperoxide resistance protein SC10_B2orf02337 ENOG4107Y2X deaminase SC10_B2orf02338 ENOG4105CVJ phosphoglycerate mutase SC10_B2orf02344 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) SC10_B2orf02345 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin SC10_B2orf02347 ENOG4105CJW magnesium transporter SC10_B2orf02349 ENOG4105V75 Transcriptional regulator SC10_B2orf02353 ENOG4105DQE DNA ligase SC10_B2orf02355 ENOG4105FDF Could be involved in DNA repair (By similarity) SC10_B2orf02357 ENOG4105BZU Histidine kinase SC10_B2orf02359 ENOG4107T5V SNARE associated Golgi SC10_B2orf02361 ENOG4107TS3 membrane protein, TerC SC10_B2orf02362 ENOG4108WZW RNA polymerase sigma SC10_B2orf02364 ENOG410681C small acid-soluble spore protein SC10_B2orf02367 ENOG4105D0M Protease HtpX homolog SC10_B2orf02371 ENOG4107RVG penicillin-binding protein SC10_B2orf02376 ENOG4108TGC Acyltransferase SC10_B2orf02377 ENOG4105BZU Histidine kinase SC10_B2orf02378 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) SC10_B2orf02381 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) SC10_B2orf02385 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase SC10_B2orf02388 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate SC10_B2orf02392 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) SC10_B2orf02395 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) SC10_B2orf02399 ENOG4105BZU Histidine kinase SC10_B2orf02400 ENOG41090MY MarR family Transcriptional regulator SC10_B2orf02401 ENOG4105ER2 Ompa motb domain protein SC10_B2orf02403 ENOG4105E14 MotA TolQ exbB proton channel SC10_B2orf02406 ENOG4108K88 Membrane SC10_B2orf02408 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) SC10_B2orf02409 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase SC10_B2orf02410 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) SC10_B2orf02411 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) SC10_B2orf02415 ENOG4105NX3 Membrane SC10_B2orf02416 ENOG4105VMP Transcriptional regulator SC10_B2orf02430 ENOG4105F0V Cell wall hydrolase SC10_B2orf02434 ENOG4105C59 p-type ATPase SC10_B2orf02435 ENOG4105DC7 peptidase M24 SC10_B2orf02443 ENOG4105CID antiterminator SC10_B2orf02447 ENOG4105KRI phosphocarrier protein (HPr SC10_B2orf02449 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) SC10_B2orf02452 ENOG4105F6S Spore photoproduct lyase SC10_B2orf02454 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer SC10_B2orf02455 ENOG4105CHR reductase SC10_B2orf02456 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase SC10_B2orf02459 ENOG4105K4I Scp-like extracellular SC10_B2orf02461 ENOG4105BZU Histidine kinase SC10_B2orf02462 ENOG4105CHM Aminotransferase SC10_B2orf02466 ENOG4107R88 Chemotaxis protein (CheV) SC10_B2orf02468 ENOG4105UIN SC10_B2orf02470 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein SC10_B2orf02475 ENOG4105K6S Short-chain dehydrogenase reductase Sdr SC10_B2orf02476 ENOG4105EPM Diguanylate phosphodiesterase SC10_B2orf02481 ENOG4107IN1 Protein of unknown function (DUF1797) SC10_B2orf02484 ENOG4108XRC Protein of unknown function (DUF458) SC10_B2orf02496 ENOG4105NQC Flavodoxin SC10_B2orf02498 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) SC10_B2orf02502 ENOG4105D3R alkyl hydroperoxide reductase SC10_B2orf02504 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SC10_B2orf02509 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) SC10_B2orf02510 ENOG4105D06 uba thif-type nad fad binding protein SC10_B2orf02511 ENOG4105CVM Molybdenum cofactor synthesis domain protein SC10_B2orf02512 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein SC10_B2orf02513 ENOG4108ZAF Molybdopterin SC10_B2orf02515 ENOG41067WU Molybdopterin converting factor (Subunit 1) SC10_B2orf02517 ENOG4105BZ1 (ABC) transporter SC10_B2orf02518 ENOG4105BZ1 (ABC) transporter SC10_B2orf02521 ENOG4107X8C Efflux transporter RND family MFP subunit SC10_B2orf02522 ENOG4105C19 ABC transporter SC10_B2orf02523 ENOG4107RBB ABC transporter, permease SC10_B2orf02525 ENOG4105E98 transcriptional regulator DeoR family SC10_B2orf02526 ENOG4105DE4 1-phosphofructokinase SC10_B2orf02527 ENOG4105DM4 PTS System SC10_B2orf02529 ENOG4105C3F Signal peptidase i SC10_B2orf02535 ENOG4105C5H ABC transporter SC10_B2orf02543 ENOG4105BZU Histidine kinase SC10_B2orf02545 ENOG4107ZYR domain protein SC10_B2orf02549 ENOG4105CN5 Metallo-Beta-Lactamase SC10_B2orf02553 ENOG4108X4Q Hydrolase SC10_B2orf02554 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) SC10_B2orf02558 ENOG4105CPP Dehydrogenase, E1 component SC10_B2orf02559 ENOG4105C7S Dehydrogenase SC10_B2orf02561 ENOG4107QN2 dihydrolipoyl dehydrogenase SC10_B2orf02567 ENOG4105CXN decarboxylase SC10_B2orf02568 ENOG4105WBI UPF0223 protein SC10_B2orf02573 ENOG4105ECY inositol monophosphatase SC10_B2orf02582 ENOG4105CI3 gtp-binding protein typa SC10_B2orf02583 ENOG4105QA2 SC10_B2orf02584 ENOG4108INS Transcriptional regulator SC10_B2orf02586 ENOG4107SCK Monooxygenase SC10_B2orf02590 ENOG4108IAB Phoh family SC10_B2orf02594 ENOG4105CSV Glutaminase SC10_B2orf02595 ENOG4105ZPI UPF0358 protein SC10_B2orf02598 ENOG4105CNI cell division protein FtsW SC10_B2orf02600 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) SC10_B2orf02604 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) SC10_B2orf02607 ENOG4105BZ9 Cytochrome C oxidase, subunit I SC10_B2orf02608 ENOG4105CCU oxidase (Subunit III) SC10_B2orf02609 ENOG41064X9 cytochrome C oxidase subunit IV SC10_B2orf02615 ENOG41080XQ Signal transduction protein with cbs domains SC10_B2orf02617 ENOG4106UY4 Inherit from COG: Scp-like extracellular SC10_B2orf02623 ENOG4106H78 methyltransferase SC10_B2orf02624 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) SC10_B2orf02627 ENOG4105H20 Sporulation integral membrane protein YlbJ SC10_B2orf02628 ENOG41063PX domain protein SC10_B2orf02630 ENOG4105CDE UPF0348 protein SC10_B2orf02632 ENOG4105KNH Nucleic acid-binding protein SC10_B2orf02639 ENOG41074B2 UPF0747 protein SC10_B2orf02640 ENOG4108V6E Cell division protein mraZ SC10_B2orf02641 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) SC10_B2orf02644 ENOG4105CJN penicillin-binding protein SC10_B2orf02645 ENOG4105CJN penicillin-binding protein SC10_B2orf02647 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) SC10_B2orf02648 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) SC10_B2orf02649 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) SC10_B2orf02650 ENOG4105CNI cell division protein FtsW SC10_B2orf02651 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) SC10_B2orf02654 ENOG4105D4A Cell wall formation (By similarity) SC10_B2orf02657 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) SC10_B2orf02658 ENOG4108R2U division initiation protein SC10_B2orf02661 ENOG4105K67 small basic protein SC10_B2orf02662 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) SC10_B2orf02663 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) SC10_B2orf02672 ENOG4105FFI sigma-e processing peptidase spoiiga SC10_B2orf02673 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf02677 ENOG4105DKW ABC transporter SC10_B2orf02679 ENOG4105DHI Methyltransferase SC10_B2orf02681 ENOG4105WR5 sporulation protein, YlmC YmxH family SC10_B2orf02684 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase SC10_B2orf02686 ENOG4105DFA alanine racemase domain protein SC10_B2orf02687 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) SC10_B2orf02688 ENOG41067XK integral membrane protein SC10_B2orf02691 ENOG4105DBK s4 domain protein SC10_B2orf02698 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) SC10_B2orf02699 ENOG4105C34 Pseudouridine synthase SC10_B2orf02700 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) SC10_B2orf02703 ENOG4105CXT aspartate transcarbamylase SC10_B2orf02704 ENOG4105CD3 dihydroorotase SC10_B2orf02705 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain SC10_B2orf02707 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain SC10_B2orf02709 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) SC10_B2orf02710 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) SC10_B2orf02711 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) SC10_B2orf02715 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) SC10_B2orf02719 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) SC10_B2orf02721 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein SC10_B2orf02722 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein SC10_B2orf02723 ENOG4105F23 Fibronectin-binding protein SC10_B2orf02727 ENOG4105DSJ YicC domain protein SC10_B2orf02728 ENOG4105KC4 UPF0296 protein SC10_B2orf02729 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) SC10_B2orf02730 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) SC10_B2orf02731 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase SC10_B2orf02732 ENOG4105C25 Primosomal protein n' SC10_B2orf02734 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) SC10_B2orf02735 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) SC10_B2orf02736 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B SC10_B2orf02737 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs SC10_B2orf02739 ENOG4108ZF3 Phosphatase SC10_B2orf02740 ENOG4105D9P serine threonine protein kinase SC10_B2orf02741 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) SC10_B2orf02742 ENOG4105DJV ribulose-phosphate 3-epimerase SC10_B2orf02744 ENOG4105FJ0 thiamine SC10_B2orf02746 ENOG4105VB9 50S ribosomal protein l28 SC10_B2orf02747 ENOG4108ZAA Alkaline-shock protein SC10_B2orf02748 ENOG4105DP4 dak2 domain fusion protein ylov SC10_B2orf02750 ENOG4105EJQ L-serine dehydratase SC10_B2orf02751 ENOG4105CB5 ATP-dependent DNA helicase recG SC10_B2orf02752 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) SC10_B2orf02755 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) SC10_B2orf02756 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase SC10_B2orf02758 ENOG4105CHR reductase SC10_B2orf02759 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) SC10_B2orf02760 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) SC10_B2orf02763 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) SC10_B2orf02764 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) SC10_B2orf02765 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) SC10_B2orf02767 ENOG4105K5M 30s ribosomal protein S16 SC10_B2orf02768 ENOG4108BW8 UPF0109 protein SC10_B2orf02770 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) SC10_B2orf02771 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) SC10_B2orf02774 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) SC10_B2orf02775 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) SC10_B2orf02777 ENOG4105VM1 flagellar SC10_B2orf02778 ENOG4105CMV Succinyl-CoA synthetase subunit beta SC10_B2orf02779 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha SC10_B2orf02783 ENOG4105C79 DNA protecting protein DprA SC10_B2orf02784 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) SC10_B2orf02786 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) SC10_B2orf02787 ENOG4108HE4 integrase family SC10_B2orf02788 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) SC10_B2orf02789 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) SC10_B2orf02790 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) SC10_B2orf02791 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) SC10_B2orf02793 ENOG4108ZC9 flagellar basal-body rod protein flgc SC10_B2orf02795 ENOG4105VQ0 flagellar hook-basal body complex protein fliE SC10_B2orf02796 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) SC10_B2orf02797 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) SC10_B2orf02801 ENOG4106YF4 Flagellar biosynthesis chaperone SC10_B2orf02804 ENOG410696Y Flagellar hook-length control protein SC10_B2orf02805 ENOG410822I Flagellar hook capping protein SC10_B2orf02806 ENOG4108JQA flagellar SC10_B2orf02808 ENOG41068WV flagellar FlbD family protein SC10_B2orf02810 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) SC10_B2orf02811 ENOG4105DD5 Flagellar motor switch protein SC10_B2orf02812 ENOG4107YTP response regulator receiver protein SC10_B2orf02815 ENOG4105CN7 Flagellar biosynthetic protein FliP SC10_B2orf02816 ENOG4105VS8 Flagellar biosynthetic protein fliq SC10_B2orf02817 ENOG4105D19 Role in flagellar biosynthesis (By similarity) SC10_B2orf02818 ENOG4105D00 flagellar biosynthetic protein flhB SC10_B2orf02820 ENOG4105D7B Flagellar biosynthesis protein flha SC10_B2orf02821 ENOG4105FZW flagellar biosynthesis regulator FlhF SC10_B2orf02823 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) SC10_B2orf02825 ENOG4105CBS Chea signal transduction histidine kinase SC10_B2orf02827 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis SC10_B2orf02829 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) SC10_B2orf02830 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf02833 ENOG4105CE9 30S ribosomal protein S2 SC10_B2orf02835 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) SC10_B2orf02839 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) SC10_B2orf02840 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) SC10_B2orf02841 ENOG4105KNE Phosphatidate cytidylyltransferase SC10_B2orf02844 ENOG4105DZP Membrane-associated zinc metalloprotease SC10_B2orf02848 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) SC10_B2orf02855 ENOG4105CYP glycoside hydrolase, family SC10_B2orf02860 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) SC10_B2orf02862 ENOG4105CHV Transcription elongation factor NusA SC10_B2orf02863 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination SC10_B2orf02864 ENOG4105VHM ribosomal protein SC10_B2orf02865 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) SC10_B2orf02866 ENOG4105W7A Protein of unknown function (DUF503) SC10_B2orf02867 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) SC10_B2orf02868 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) SC10_B2orf02869 ENOG4105DTN riboflavin biosynthesis protein ribF SC10_B2orf02871 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) SC10_B2orf02873 ENOG4105C1V Peptidase, M16 SC10_B2orf02876 ENOG4105E35 Dipicolinate synthase subunit A SC10_B2orf02878 ENOG4108S0H Dipicolinic acid synthetase, b subunit SC10_B2orf02879 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) SC10_B2orf02882 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SC10_B2orf02887 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit SC10_B2orf02890 ENOG4105CNU cell division protein FtsK SC10_B2orf02891 ENOG4105FDP GntR family transcriptional regulator SC10_B2orf02899 ENOG4108RKS Short-chain dehydrogenase reductase Sdr SC10_B2orf02900 ENOG4105XZV Protein of unknown function (DUF3243) SC10_B2orf02905 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase SC10_B2orf02906 ENOG4105CEV competence damage-inducible protein SC10_B2orf02908 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) SC10_B2orf02912 ENOG4105D48 metallophosphoesterase SC10_B2orf02913 ENOG4105MCT stage V sporulation protein S SC10_B2orf02914 ENOG4108IGT Dipeptidase SC10_B2orf02915 ENOG4105CPQ Dehydrogenase SC10_B2orf02916 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) SC10_B2orf02918 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) SC10_B2orf02922 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) SC10_B2orf02923 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) SC10_B2orf02925 ENOG4106ANW SMI1_KNR4 SC10_B2orf02929 ENOG4107EV6 Inherit from COG: YD repeat protein SC10_B2orf02931 ENOG4105CKI cobalamin synthesis protein SC10_B2orf02934 ENOG4105G7B Protein of unknown function (DUF2992) SC10_B2orf02937 ENOG4105XPP Protein of unknown function (DUF1275) SC10_B2orf02938 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) SC10_B2orf02941 ENOG4108J8C transporter major facilitator family protein SC10_B2orf02945 ENOG41080BT SNARE associated Golgi SC10_B2orf02947 ENOG4105FQP Beta-lactamase SC10_B2orf02948 ENOG41087PP glycosyltransferase MGT family SC10_B2orf02949 ENOG4107QTZ amino acid SC10_B2orf02953 ENOG4105VRS hydrolase family 18 SC10_B2orf02954 ENOG4105M4P Tetr family transcriptional regulator SC10_B2orf02955 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein SC10_B2orf02960 ENOG4108X3M OsmC Ohr family protein SC10_B2orf02961 ENOG4107E54 Small Multidrug Resistance protein SC10_B2orf02969 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) SC10_B2orf02970 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) SC10_B2orf02972 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) SC10_B2orf02973 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SC10_B2orf02974 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) SC10_B2orf02975 ENOG4105U6W MutT NUDIX family protein SC10_B2orf02978 ENOG4108UNV SUF system FeS assembly protein, NifU family SC10_B2orf02980 ENOG4105G5W regulator Fur family SC10_B2orf02981 ENOG4105DRR Transcriptional regulator, GntR family SC10_B2orf03009 ENOG4108YZ9 Urea amidohydrolase subunit gamma SC10_B2orf03011 ENOG4105KI2 Urea amidohydrolase subunit beta SC10_B2orf03013 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) SC10_B2orf03014 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) SC10_B2orf03015 ENOG4105E8T Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) SC10_B2orf03016 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) SC10_B2orf03018 ENOG4105U3E Transcriptional regulator SC10_B2orf03023 ENOG4106F1P AAA ATPase, central domain protein SC10_B2orf03024 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) SC10_B2orf03026 ENOG4105CXI aluminum resistance protein SC10_B2orf03027 ENOG4105KV4 Transcriptional regulator SC10_B2orf03028 ENOG4105C5F glutamine synthetase SC10_B2orf03033 ENOG4105C5F glutamine synthetase SC10_B2orf03041 ENOG4105NCW Trka-c domain protein SC10_B2orf03042 ENOG4107S91 Sodium hydrogen exchanger SC10_B2orf03061 ENOG4108MK9 spermidine N(1)-acetyltransferase SC10_B2orf03065 ENOG4107USA Thioredoxin SC10_B2orf03071 ENOG41062JF Transcriptional regulator SC10_B2orf03073 ENOG41090MY MarR family Transcriptional regulator SC10_B2orf03074 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase SC10_B2orf03075 ENOG4107XWI flavin reductase domain protein, FMN-binding SC10_B2orf03076 ENOG4105CS1 NAD(P)H quinone oxidoreductase SC10_B2orf03082 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) SC10_B2orf03087 ENOG4105WFK nuclease SC10_B2orf03089 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) SC10_B2orf03092 ENOG4108SVB resolvase SC10_B2orf03093 ENOG4105VPS UPF0291 protein SC10_B2orf03094 ENOG4105CV1 Transketolase (EC 2.2.1.1) SC10_B2orf03096 ENOG4105VXM UPF0154 protein SC10_B2orf03098 ENOG4107QIV Cytochrome c biogenesis protein SC10_B2orf03107 ENOG41076DU acid-soluble spore protein P SC10_B2orf03109 ENOG4108I0Z Aconitate hydratase SC10_B2orf03111 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SC10_B2orf03119 ENOG4105MI2 SC10_B2orf03128 ENOG4105W8X HesB YadR YfhF-family protein SC10_B2orf03129 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) SC10_B2orf03132 ENOG4105K4P CoA-binding domain protein SC10_B2orf03136 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) SC10_B2orf03138 ENOG4105CMD Transcriptional regulator, GntR family SC10_B2orf03141 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) SC10_B2orf03142 ENOG4107QNK )-transporter SC10_B2orf03144 ENOG4105CHR reductase SC10_B2orf03154 ENOG4105R3A Nitrate reductase SC10_B2orf03156 ENOG4108IUE nitrate reductase beta subunit SC10_B2orf03170 ENOG4107V6Q Cyclic nucleotide-binding domain SC10_B2orf03177 ENOG4105DSQ Nitric oxide reductase SC10_B2orf03179 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) SC10_B2orf03180 ENOG4106U2H Protein of unknown function (DUF1360) SC10_B2orf03183 ENOG4107QWR cellulase (EC 3.2.1.4) SC10_B2orf03186 ENOG4108428 Inherit from COG: -acetyltransferase SC10_B2orf03189 ENOG4107UWP Major facilitator superfamily MFS_1 SC10_B2orf03191 ENOG4108M26 parallel beta-helix repeat protein SC10_B2orf03195 ENOG4105KMT branched-chain amino acid SC10_B2orf03196 ENOG4108UMN azlc family SC10_B2orf03197 ENOG4107U9B transcriptional regulator SC10_B2orf03207 ENOG41060WC Enoyl-CoA hydratase SC10_B2orf03208 ENOG4105C26 Dehydrogenase SC10_B2orf03209 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase SC10_B2orf03210 ENOG4105C1G acyl-Coa dehydrogenase SC10_B2orf03213 ENOG4105DG6 mannose-6-phosphate isomerase SC10_B2orf03214 ENOG4105DM4 PTS System SC10_B2orf03223 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family SC10_B2orf03225 ENOG4105DMW Dehydrogenase reductase SC10_B2orf03226 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) SC10_B2orf03228 ENOG4105CG6 trap dicarboxylate transporter dctm subunit SC10_B2orf03231 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit SC10_B2orf03232 ENOG4107KJX Transcriptional regulator SC10_B2orf03236 ENOG4108UXE Protein tyrosine phosphatase SC10_B2orf03237 ENOG4107R5R arsenical pump membrane protein SC10_B2orf03239 ENOG41082YX Transcriptional regulator, arsr family SC10_B2orf03242 ENOG4105CZ9 Domain of unknown function (DU1801) SC10_B2orf03245 ENOG4105CSC Glucose uptake protein SC10_B2orf03247 ENOG4105F32 YngK protein SC10_B2orf03252 ENOG4105F1A Pyruvate formate-lyase SC10_B2orf03255 ENOG4105CGN Glycosyl transferase (Group 1 SC10_B2orf03256 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family SC10_B2orf03263 ENOG4108RZE Tetr family transcriptional regulator SC10_B2orf03272 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) SC10_B2orf03274 ENOG4107QX3 carboxylase SC10_B2orf03275 ENOG4105E39 Enoyl-CoA hydratase SC10_B2orf03276 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase SC10_B2orf03279 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit SC10_B2orf03280 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase SC10_B2orf03285 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf03295 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf03296 ENOG4105C1G acyl-Coa dehydrogenase SC10_B2orf03297 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein SC10_B2orf03299 ENOG4105KVH Transcriptional regulator SC10_B2orf03301 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) SC10_B2orf03303 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) SC10_B2orf03306 ENOG4105H67 Protein of unknown function (DUF421) SC10_B2orf03310 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) SC10_B2orf03312 ENOG41061P3 phosphosulfolactate synthase SC10_B2orf03315 ENOG4105DIA mandelate racemase muconate lactonizing SC10_B2orf03317 ENOG4107RCC Major Facilitator Superfamily SC10_B2orf03326 ENOG4105BZ8 glutamate synthase SC10_B2orf03328 ENOG4105CBC glutamate synthase SC10_B2orf03329 ENOG4105C5Q Transcriptional regulator SC10_B2orf03338 ENOG4105BZ1 (ABC) transporter SC10_B2orf03344 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) SC10_B2orf03345 ENOG4105C0R drug resistance transporter emrb qaca subfamily SC10_B2orf03347 ENOG4108J2R molybdopterin oxidoreductase SC10_B2orf03350 ENOG4108Q8B Spore germination protein SC10_B2orf03351 ENOG4108NHD germination protein SC10_B2orf03352 ENOG4108Q8B Spore germination protein SC10_B2orf03354 ENOG4108Q8B Spore germination protein SC10_B2orf03362 ENOG4105C8Q Methyl-accepting chemotaxis SC10_B2orf03363 ENOG4108Z7R Chaperone CsaA SC10_B2orf03364 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin SC10_B2orf03367 ENOG4108RZE Tetr family transcriptional regulator SC10_B2orf03369 ENOG4105T9C HD domain SC10_B2orf03371 ENOG4105FVX SC10_B2orf03377 ENOG4108W8B Beta-lactamase domain protein SC10_B2orf03383 ENOG4105D29 Helix-turn-helix type 11 domain protein SC10_B2orf03385 ENOG4105KTU Transcriptional regulator, arsr family SC10_B2orf03390 ENOG4105CUB amino acid SC10_B2orf03395 ENOG4105C5E polysaccharide biosynthesis protein SC10_B2orf03398 ENOG4105CPK Glycosyl transferase (Group 1 SC10_B2orf03399 ENOG4108SJC Membrane SC10_B2orf03407 ENOG4107RUZ Sss sodium solute transporter superfamily SC10_B2orf03410 ENOG41069ER domain protein SC10_B2orf03411 ENOG4105C9U ATP-dependent DNA helicase RecQ SC10_B2orf03417 ENOG4105UNS Pfam:DUF419 SC10_B2orf03421 ENOG4108IEG Formate dehydrogenase Alpha subunit SC10_B2orf03426 ENOG4107EV6 Inherit from COG: YD repeat protein SC10_B2orf03427 ENOG4107EV6 Inherit from COG: YD repeat protein SC10_B2orf03433 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) SC10_B2orf03443 ENOG41068K0 YCII-related domain SC10_B2orf03451 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) SC10_B2orf03454 ENOG4107S9D Alpha beta hydrolase SC10_B2orf03459 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) SC10_B2orf03462 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) SC10_B2orf03468 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) SC10_B2orf03472 ENOG4105SCY DNAK suppressor SC10_B2orf03479 ENOG4105C26 Dehydrogenase SC10_B2orf03487 ENOG4105EWU Squalene--hopene cyclase SC10_B2orf03488 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) SC10_B2orf03494 ENOG4105C8J )-transporter SC10_B2orf03495 ENOG4105C09 Bile acid SC10_B2orf03496 ENOG4105C7S Dehydrogenase SC10_B2orf03497 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 SC10_B2orf03499 ENOG4107T89 von Willebrand factor, type A SC10_B2orf03500 ENOG4105GMT ATPase associated with various cellular activities aaa_5 SC10_B2orf03506 ENOG4105K4H Nlp p60 protein SC10_B2orf03518 ENOG4105FR1 rard protein SC10_B2orf03524 ENOG4108YQE rare lipoprotein a SC10_B2orf03527 ENOG4107EXU Short-chain dehydrogenase reductase Sdr SC10_B2orf03530 ENOG4105FBA Phospholipase Carboxylesterase SC10_B2orf03533 ENOG4105E1V na solute symporter SC10_B2orf03539 ENOG4108VXD carboxy-peptidase SC10_B2orf03541 ENOG4105D3A purine nucleoside phosphorylase DeoD-type SC10_B2orf03543 ENOG4108PJD permease SC10_B2orf03546 ENOG4106Z5R SC10_B2orf03547 ENOG410841Q phosphoesterase PA-phosphatase related protein SC10_B2orf03552 ENOG4105VSD UPF0346 protein SC10_B2orf03556 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein SC10_B2orf03558 ENOG4108TSC N-acetyltransferase SC10_B2orf03559 ENOG4107S4Y M20 DapE family protein YgeY SC10_B2orf03564 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) SC10_B2orf03569 ENOG4105E0X reductase SC10_B2orf03583 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) SC10_B2orf03585 ENOG41090WU lipolytic protein G-D-S-L family SC10_B2orf03587 ENOG4108KF3 Electron transport protein SCO1 SenC SC10_B2orf03593 ENOG4105C7B Threonine dehydratase SC10_B2orf03595 ENOG4108UT2 hemolysin iii SC10_B2orf03598 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) SC10_B2orf03604 ENOG4107YX5 Pfam:DUF548 SC10_B2orf03606 ENOG4105C01 Dihydroxy-acid dehydratase SC10_B2orf03611 ENOG4108V06 Glutathione peroxidase SC10_B2orf03612 ENOG4105CKU formyltetrahydrofolate synthetase SC10_B2orf03614 ENOG4105CVG Homoserine O-transsuccinylase SC10_B2orf03615 ENOG4108QBV Monogalactosyldiacylglycerol synthase SC10_B2orf03624 ENOG41081VK Ribonuclease SC10_B2orf03631 ENOG410890F Dynamin family SC10_B2orf03636 ENOG41065KQ synthase SC10_B2orf03641 ENOG4105C2W permease SC10_B2orf03642 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) SC10_B2orf03644 ENOG4105CTD carboxy-peptidase SC10_B2orf03646 ENOG4105DVT helicase SC10_B2orf03654 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) SC10_B2orf03655 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) SC10_B2orf03656 ENOG4108UKS UPF0398 protein SC10_B2orf03658 ENOG4107X2U Inherit from COG: Exonuclease-like protein SC10_B2orf03659 ENOG4108I5C dEAD DEAH box helicase SC10_B2orf03675 ENOG4105BZ4 penicillin-binding protein SC10_B2orf03679 ENOG4105CSM endonuclease III SC10_B2orf03683 ENOG4105CHM Aminotransferase SC10_B2orf03685 ENOG4105YAC SC10_B2orf03686 ENOG4105DVT helicase SC10_B2orf03688 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) SC10_B2orf03689 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) SC10_B2orf03691 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) SC10_B2orf03693 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate SC10_B2orf03695 ENOG4105CPK Glycosyl transferase (Group 1 SC10_B2orf03696 ENOG4105FJR Lmbe family SC10_B2orf03698 ENOG4108Z5K methylglyoxal synthase SC10_B2orf03700 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) SC10_B2orf03702 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase SC10_B2orf03703 ENOG4108JYZ YitT family SC10_B2orf03711 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) SC10_B2orf03714 ENOG4108SXZ UPF0302 protein SC10_B2orf03715 ENOG41068YB TPR repeat-containing protein SC10_B2orf03719 ENOG4105CIH Imidazole acetol-phosphate transaminase SC10_B2orf03720 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) SC10_B2orf03721 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) SC10_B2orf03723 ENOG4105DK0 Indole-3-glycerol phosphate synthase SC10_B2orf03724 ENOG4108I0Q anthranilate phosphoribosyltransferase SC10_B2orf03725 ENOG4105CRQ synthase (Component I) SC10_B2orf03726 ENOG4105KHN chorismate mutase SC10_B2orf03728 ENOG4105D49 3-dehydroquinate synthase SC10_B2orf03730 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase SC10_B2orf03731 ENOG4105BZU Histidine kinase SC10_B2orf03732 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) SC10_B2orf03733 ENOG4105EAH synthase SC10_B2orf03734 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) SC10_B2orf03736 ENOG4105XXQ heptaprenyl diphosphate synthase component I SC10_B2orf03738 ENOG4105EUJ GTP cyclohydrolase i SC10_B2orf03740 ENOG4105K70 DNA-binding protein SC10_B2orf03744 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) SC10_B2orf03749 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase SC10_B2orf03751 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) SC10_B2orf03752 ENOG41065D1 SC10_B2orf03754 ENOG4105S2F SC10_B2orf03757 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) SC10_B2orf03760 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) SC10_B2orf03761 ENOG4105CAT Cytidine monophosphate kinase SC10_B2orf03764 ENOG4105MSI germination protein ypeb SC10_B2orf03768 ENOG4105HDK L-asparaginase SC10_B2orf03769 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase SC10_B2orf03774 ENOG4107RGJ metallophosphoesterase SC10_B2orf03778 ENOG4105I7S Abortive infection protein SC10_B2orf03779 ENOG4105C9U ATP-dependent DNA helicase RecQ SC10_B2orf03780 ENOG4105T7X SC10_B2orf03783 ENOG4108SAX Membrane SC10_B2orf03786 ENOG4108JQ1 Dehydrogenase SC10_B2orf03787 ENOG4105DR5 peptidase SC10_B2orf03790 ENOG4108KGH TRANSCRIPTIONal SC10_B2orf03795 ENOG4105US7 Histidine kinase SC10_B2orf03796 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SC10_B2orf03797 ENOG4105BZU Histidine kinase SC10_B2orf03798 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SC10_B2orf03800 ENOG4105CRE cytochrome C SC10_B2orf03802 ENOG4107TWT Cytochrome c biogenesis protein SC10_B2orf03803 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen SC10_B2orf03805 ENOG4105FE9 pseudouridine synthase SC10_B2orf03807 ENOG4108JIC nucleoside recognition domain protein SC10_B2orf03808 ENOG4105DZ1 carboxypeptidase SC10_B2orf03811 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) SC10_B2orf03812 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) SC10_B2orf03815 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) SC10_B2orf03816 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) SC10_B2orf03818 ENOG4108R6K riboflavin synthase, subunit alpha SC10_B2orf03819 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) SC10_B2orf03824 ENOG4105MEW serine threonine protein phosphatase SC10_B2orf03827 ENOG4107ZE5 PPIases accelerate the folding of proteins SC10_B2orf03831 ENOG4105PTM secreted protein SC10_B2orf03832 ENOG4105K7W phage-related replication protein SC10_B2orf03836 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) SC10_B2orf03841 ENOG4105G6R Stage v sporulation protein ae SC10_B2orf03845 ENOG4105CZ3 stage V sporulation protein ad SC10_B2orf03846 ENOG41090VF Stage v sporulation protein ac SC10_B2orf03850 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf03852 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) SC10_B2orf03853 ENOG41082AN stage II sporulation protein SC10_B2orf03854 ENOG4105DZ1 carboxypeptidase SC10_B2orf03855 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) SC10_B2orf03858 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) SC10_B2orf03859 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) SC10_B2orf03861 ENOG4105I3K Ferric uptake regulator, Fur family SC10_B2orf03863 ENOG4105MZ9 stage II sporulation protein m SC10_B2orf03864 ENOG4105CK1 PTS System SC10_B2orf03866 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease SC10_B2orf03873 ENOG4107YB6 acetyltransferase, (GNAT) family SC10_B2orf03875 ENOG4108YZ4 nudix hydrolase SC10_B2orf03877 ENOG4105PF9 Transcriptional regulator SC10_B2orf03879 ENOG4105CPC Aldo Keto reductase SC10_B2orf03886 ENOG4106HZJ SC10_B2orf03888 ENOG4105RHY Pfam:UPF0157 SC10_B2orf03890 ENOG4105KAC Antibiotic biosynthesis monooxygenase SC10_B2orf03895 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold SC10_B2orf03899 ENOG4107RRN ABC transporter substrate-binding protein SC10_B2orf03900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SC10_B2orf03901 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SC10_B2orf03902 ENOG4108RZA ABC transporter SC10_B2orf03906 ENOG4107R73 Mate efflux family protein SC10_B2orf03910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) SC10_B2orf03914 ENOG4105E5W Transporter SC10_B2orf03917 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase SC10_B2orf03922 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) SC10_B2orf03932 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SC10_B2orf03945 ENOG4105K7W phage-related replication protein SC10_B2orf03949 ENOG4108IXY short-chain dehydrogenase reductase SC10_B2orf03951 ENOG41069FQ Metallo-beta-lactamase superfamily SC10_B2orf03953 ENOG4105II7 pyrroline-5-carboxylate reductase SC10_B2orf03958 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase SC10_B2orf03961 ENOG4105WDJ 50S ribosomal protein L33 SC10_B2orf03963 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) SC10_B2orf03964 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase SC10_B2orf03972 ENOG4108TZY GntR Family Transcriptional Regulator SC10_B2orf03974 ENOG4105CS2 ec 3.2.1.21 SC10_B2orf03975 ENOG4105CK1 PTS System SC10_B2orf03977 ENOG4105VCP PTS System SC10_B2orf03979 ENOG4105VZJ PTS System SC10_B2orf03981 ENOG4105G6Z alkaline phosphatase SC10_B2orf03982 ENOG4105H9W Short-chain dehydrogenase reductase Sdr SC10_B2orf03983 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) SC10_B2orf03985 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) SC10_B2orf03988 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) SC10_B2orf03989 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) SC10_B2orf03990 ENOG4108HNZ carboxyl transferase SC10_B2orf03993 ENOG4108QEG Membrane SC10_B2orf03994 ENOG4105CDA abc transporter atp-binding protein SC10_B2orf03996 ENOG4105E5Q amino acid AbC transporter SC10_B2orf03998 ENOG4108HW3 (ABC) transporter SC10_B2orf04000 ENOG4108Y6J UPF0403 protein SC10_B2orf04001 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) SC10_B2orf04003 ENOG4105C7S Dehydrogenase SC10_B2orf04004 ENOG4105CPP Dehydrogenase, E1 component SC10_B2orf04009 ENOG4105CKM Branched-chain carboxylic acid kinase SC10_B2orf04010 ENOG4107RDP Dehydrogenase SC10_B2orf04012 ENOG4108JUB Transcriptional regulator SC10_B2orf04014 ENOG4106CCJ Protein of unknown function (DUF2627) SC10_B2orf04016 ENOG4108QXE glycerophosphoryl diester phosphodiesterase SC10_B2orf04018 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SC10_B2orf04024 ENOG4107QQR Sporulation SC10_B2orf04027 ENOG4105S1Z Stage IV sporulation protein B SC10_B2orf04028 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) SC10_B2orf04029 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) SC10_B2orf04030 ENOG4105DX0 Hemolysin A SC10_B2orf04031 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) SC10_B2orf04033 ENOG4105CTB Polyprenyl synthetase SC10_B2orf04034 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) SC10_B2orf04035 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) SC10_B2orf04036 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) SC10_B2orf04037 ENOG4105M7K Involved in the transcription termination process (By similarity) SC10_B2orf04038 ENOG4108ZSR alkaline shock protein SC10_B2orf04039 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase SC10_B2orf04044 ENOG410644B Stage III sporulation protein af SC10_B2orf04047 ENOG4105KQ4 Stage iii sporulation protein ad SC10_B2orf04049 ENOG4108CQH stage III sporulation protein AC SC10_B2orf04051 ENOG4105KR5 Stage iii sporulation protein SC10_B2orf04052 ENOG4105CD2 stage iii sporulation protein aa SC10_B2orf04055 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) SC10_B2orf04056 ENOG4105DC7 peptidase M24 SC10_B2orf04057 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) SC10_B2orf04060 ENOG4105CBJ Metal-dependent enzyme SC10_B2orf04065 ENOG4105KST dependent repressor SC10_B2orf04066 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) SC10_B2orf04067 ENOG4105WZW rhodanese family SC10_B2orf04069 ENOG4107SQ8 Glycine betaine SC10_B2orf04070 ENOG4108IJ7 Glycine betaine SC10_B2orf04074 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor SC10_B2orf04077 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) SC10_B2orf04079 ENOG4105C0D helicase SC10_B2orf04086 ENOG4105VFR signal peptidase SC10_B2orf04098 ENOG4106855 Competence protein SC10_B2orf04109 ENOG4105C5X domain protein SC10_B2orf04121 ENOG4105E0M Sulfatase SC10_B2orf04127 ENOG4107ZXI Rhomboid family SC10_B2orf04129 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase SC10_B2orf04134 ENOG41068DG YceG-like family SC10_B2orf04145 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) SC10_B2orf04146 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) SC10_B2orf04147 ENOG4105E2Z phosphate ABC transporter (Permease SC10_B2orf04148 ENOG4105C8U phosphate abc transporter SC10_B2orf04149 ENOG4105CVA phosphate SC10_B2orf04150 ENOG4107RF6 penicillin-binding protein SC10_B2orf04153 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) SC10_B2orf04154 ENOG4105SXS Protein of unknown function (DUF456) SC10_B2orf04157 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) SC10_B2orf04158 ENOG41063Y9 SC10_B2orf04159 ENOG4108U5J '-nucleotidase SC10_B2orf04161 ENOG4105N80 Ferric uptake regulator, Fur family SC10_B2orf04162 ENOG4105FAV ABC, transporter SC10_B2orf04163 ENOG4105FDK ABC transporter SC10_B2orf04165 ENOG4108JYZ YitT family SC10_B2orf04167 ENOG41069ZM Protein of unknown function (DUF2624) SC10_B2orf04168 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) SC10_B2orf04173 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) SC10_B2orf04174 ENOG4105EGD dinuclear metal center protein, YbgI family SC10_B2orf04176 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) SC10_B2orf04187 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf04190 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) SC10_B2orf04192 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) SC10_B2orf04195 ENOG4105C38 Glycyl-tRNA synthetase beta subunit SC10_B2orf04196 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit SC10_B2orf04197 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) SC10_B2orf04199 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) SC10_B2orf04200 ENOG4105KG3 cytidine deaminase SC10_B2orf04201 ENOG4107YR5 Diacylglycerol kinase SC10_B2orf04202 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) SC10_B2orf04203 ENOG4105CTJ Metal Dependent Phosphohydrolase SC10_B2orf04204 ENOG4105C9A Phoh family SC10_B2orf04205 ENOG4105EI1 sporulation protein yqfd SC10_B2orf04206 ENOG41068P3 sporulation protein YqfC SC10_B2orf04209 ENOG4105DI5 UPF0365 protein SC10_B2orf04210 ENOG4105F7J membrane-bound serine protease SC10_B2orf04212 ENOG4105KTH gatB Yqey SC10_B2orf04213 ENOG4105VCC 30S ribosomal protein S21 SC10_B2orf04216 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) SC10_B2orf04217 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) SC10_B2orf04218 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) SC10_B2orf04220 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) SC10_B2orf04221 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) SC10_B2orf04222 ENOG4105CFG Acts as a chaperone (By similarity) SC10_B2orf04223 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ SC10_B2orf04224 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) SC10_B2orf04225 ENOG4105CSA Coproporphyrinogen iii oxidase SC10_B2orf04227 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) SC10_B2orf04230 ENOG4108ZRV stage ii sporulation protein p SC10_B2orf04239 ENOG4105KVH Transcriptional regulator SC10_B2orf04242 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein SC10_B2orf04243 ENOG4105TQK DNA polymerase iii, delta' subunit SC10_B2orf04245 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 SC10_B2orf04246 ENOG4108UK2 deaminase SC10_B2orf04248 ENOG4105KQC Competence protein SC10_B2orf04252 ENOG4108D32 Methyltransferase SC10_B2orf04255 ENOG4108WF2 Metal Dependent Phosphohydrolase SC10_B2orf04256 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) SC10_B2orf04257 ENOG410812S Rna-binding protein SC10_B2orf04258 ENOG4105E2X shikimate dehydrogenase SC10_B2orf04259 ENOG4105CQW ribosome biogenesis GTPase YqeH SC10_B2orf04260 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase SC10_B2orf04265 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) SC10_B2orf04267 ENOG4108JB9 formate dehydrogenase SC10_B2orf04271 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf04275 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf04277 ENOG4108SWU Histidine kinase SC10_B2orf04278 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SC10_B2orf04280 ENOG4105DHF Membrane SC10_B2orf04281 ENOG4108UYN gCN5-related N-acetyltransferase SC10_B2orf04284 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf04285 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) SC10_B2orf04287 ENOG4105KME endoribonuclease L-psp SC10_B2orf04288 ENOG4105HDK L-asparaginase SC10_B2orf04289 ENOG4105C6T cysteine synthase SC10_B2orf04290 ENOG4105KME endoribonuclease L-psp SC10_B2orf04293 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf04297 ENOG4108Z5V transcriptional regulator, merr family SC10_B2orf04302 ENOG4105JSC dimethylmenaquinone methyltransferase SC10_B2orf04303 ENOG4105C7F AcnD-accessory protein PrpF SC10_B2orf04307 ENOG4105R3A Nitrate reductase SC10_B2orf04308 ENOG4108IUE nitrate reductase beta subunit SC10_B2orf04312 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) SC10_B2orf04313 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) SC10_B2orf04315 ENOG4105W1N transcriptional regulator SC10_B2orf04324 ENOG4105WH1 Two component transcriptional regulator luxr family SC10_B2orf04325 ENOG4105BZU Histidine kinase SC10_B2orf04326 ENOG4105XXY Thioredoxin SC10_B2orf04327 ENOG41087NI Sulfite exporter TauE/SafE SC10_B2orf04328 ENOG4105VFE sira family SC10_B2orf04329 ENOG4107TPS domain protein SC10_B2orf04332 ENOG4105VFE sira family SC10_B2orf04333 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase SC10_B2orf04334 ENOG4105XTG Pfam:DUF156 SC10_B2orf04336 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) SC10_B2orf04341 ENOG41090U3 tautomerase SC10_B2orf04343 ENOG41080HJ 6-phospho 3-hexuloisomerase SC10_B2orf04344 ENOG4108VA3 3-hexulose-6-phosphate synthase SC10_B2orf04345 ENOG4105KVH Transcriptional regulator SC10_B2orf04346 ENOG4105ECK Fatty Acid Desaturase SC10_B2orf04347 ENOG4108ZGX Histidine kinase SC10_B2orf04348 ENOG4108S01 response regulator SC10_B2orf04349 ENOG4105CAY ferredoxin--nadp reductase SC10_B2orf04351 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein SC10_B2orf04352 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component SC10_B2orf04353 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component SC10_B2orf04355 ENOG4108JQ7 (ABC) transporter SC10_B2orf04360 ENOG4108ZX5 transcriptional regulator SC10_B2orf04361 ENOG4105EWI Short-chain dehydrogenase reductase Sdr SC10_B2orf04364 ENOG4105FTQ Dna gyrase SC10_B2orf04369 ENOG4105DSG hydrolase family 43 SC10_B2orf04370 ENOG4105CT4 transporter SC10_B2orf04377 ENOG4105EWI Short-chain dehydrogenase reductase Sdr SC10_B2orf04379 ENOG4108HKT sucrose-6-phosphate hydrolase SC10_B2orf04380 ENOG4105F3R pts system mannose fructose sorbose family iid SC10_B2orf04381 ENOG4105ETZ PTS System SC10_B2orf04382 ENOG4108IQ3 PTS system SC10_B2orf04384 ENOG4105YHU PTS system SC10_B2orf04387 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family SC10_B2orf04391 ENOG4105WDR SC10_B2orf04397 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) SC10_B2orf04400 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) SC10_B2orf04402 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) SC10_B2orf04403 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) SC10_B2orf04405 ENOG4105CV8 reductase SC10_B2orf04406 ENOG4105F27 Major Facilitator SC10_B2orf04407 ENOG4105KVH Transcriptional regulator SC10_B2orf04409 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) SC10_B2orf04413 ENOG4105EXQ uroporphyrinogen iii synthase hem4 SC10_B2orf04417 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) SC10_B2orf04418 ENOG4107RSM transcriptional regulator SC10_B2orf04420 ENOG4105D94 Major Facilitator Superfamily SC10_B2orf04423 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) SC10_B2orf04424 ENOG41082JN Transcriptional regulator SC10_B2orf04428 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin SC10_B2orf04436 ENOG4105C28 cystathionine SC10_B2orf04440 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) SC10_B2orf04441 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) SC10_B2orf04446 ENOG4107XRG penicillin-binding protein SC10_B2orf04448 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) SC10_B2orf04451 ENOG4105CFP Peptidase U32 SC10_B2orf04452 ENOG4105XYU peptidase (U32 family) SC10_B2orf04454 ENOG4108VQJ O-methyltransferase SC10_B2orf04456 ENOG4105HHA aminodeoxychorismate lyase SC10_B2orf04457 ENOG4105VPH UPF0473 protein SC10_B2orf04458 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) SC10_B2orf04459 ENOG4105VBH UPF0297 protein SC10_B2orf04461 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) SC10_B2orf04462 ENOG4105C02 permease SC10_B2orf04464 ENOG41060CR SC10_B2orf04467 ENOG4105C7H Helicase, RecD TraA family SC10_B2orf04472 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) SC10_B2orf04473 ENOG4105C3J Cysteine desulfurase SC10_B2orf04476 ENOG4105D1H recombination factor protein RarA SC10_B2orf04480 ENOG4105CUZ uba thif-type nad fad binding protein SC10_B2orf04482 ENOG4105C9M aspartyl-trna synthetase SC10_B2orf04484 ENOG4105CUT histidyl-tRNA synthetase SC10_B2orf04486 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SC10_B2orf04487 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) SC10_B2orf04488 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) SC10_B2orf04490 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) SC10_B2orf04492 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) SC10_B2orf04494 ENOG41067VP Protein of unknown function (DUF1049) SC10_B2orf04496 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) SC10_B2orf04499 ENOG4105CKP Polysaccharide Biosynthesis Protein SC10_B2orf04500 ENOG4108QG2 Membrane SC10_B2orf04501 ENOG4105NAP SC10_B2orf04505 ENOG4105VIE preprotein translocase, subunit YajC SC10_B2orf04506 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) SC10_B2orf04507 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) SC10_B2orf04508 ENOG41061AI Protein of unknown function (DUF2905) SC10_B2orf04510 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) SC10_B2orf04511 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) SC10_B2orf04516 ENOG41069DP small acid-soluble spore protein SC10_B2orf04518 ENOG4105K7W phage-related replication protein SC10_B2orf04523 ENOG4105CDY transcriptional regulatory protein SC10_B2orf04527 ENOG4106678 morphogenetic protein associated with SpoVID SC10_B2orf04528 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) SC10_B2orf04529 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase SC10_B2orf04531 ENOG4108IYU L-aspartate oxidase SC10_B2orf04536 ENOG4105CQC Prephenate dehydratase SC10_B2orf04537 ENOG41090I5 UPF0735 ACT domain-containing protein SC10_B2orf04539 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control SC10_B2orf04543 ENOG4105K46 50S ribosomal protein l27 SC10_B2orf04544 ENOG4105X36 (ribosomal) protein SC10_B2orf04545 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) SC10_B2orf04552 ENOG41082BM Transcriptional regulator, arsr family SC10_B2orf04554 ENOG4107QMS site-determining protein SC10_B2orf04556 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) SC10_B2orf04558 ENOG4105YHC Rod shape-determining protein MreD SC10_B2orf04559 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) SC10_B2orf04560 ENOG4105DFF Rod shape-determining protein mreb SC10_B2orf04561 ENOG4105W5Q DNA repair protein (RadC SC10_B2orf04563 ENOG4108Z03 MAF-like protein SC10_B2orf04566 ENOG4106A3R peptidase SC10_B2orf04567 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase SC10_B2orf04568 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) SC10_B2orf04572 ENOG4106AR7 Spore coat protein SC10_B2orf04573 ENOG41068KH stage VI sporulation protein D SC10_B2orf04577 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase SC10_B2orf04578 ENOG4105D52 delta-aminolevulinic acid dehydratase SC10_B2orf04581 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) SC10_B2orf04583 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) SC10_B2orf04586 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) SC10_B2orf04587 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) SC10_B2orf04589 ENOG4108IUQ atp-dependent protease SC10_B2orf04591 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) SC10_B2orf04595 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation SC10_B2orf04599 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) SC10_B2orf04601 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) SC10_B2orf04602 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) SC10_B2orf04604 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) SC10_B2orf04606 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase SC10_B2orf04608 ENOG4108ZP8 Acetolactate synthase small subunit SC10_B2orf04609 ENOG4105C7K acetolactate synthase SC10_B2orf04612 ENOG4105CM2 brancheD-chain amino acid aminotransferase SC10_B2orf04614 ENOG4107R37 Glutamate dehydrogenase SC10_B2orf04618 ENOG4105M59 Phosphodiesterase, mj0936 family SC10_B2orf04619 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) SC10_B2orf04620 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) SC10_B2orf04622 ENOG4108XJQ germination protein SC10_B2orf04623 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) SC10_B2orf04624 ENOG41067TZ transcriptional regulator, MarR family SC10_B2orf04625 ENOG4105PFC Transcriptional regulator SC10_B2orf04628 ENOG4105EMU Dehydrogenase SC10_B2orf04631 ENOG4105E33 succinate dehydrogenase SC10_B2orf04633 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit SC10_B2orf04636 ENOG4105CFH Aspartokinase SC10_B2orf04638 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) SC10_B2orf04641 ENOG4105K63 Thioredoxin SC10_B2orf04643 ENOG4105C10 Electron transfer flavoprotein SC10_B2orf04644 ENOG4105BZJ Electron transfer flavoprotein SC10_B2orf04646 ENOG41060WC Enoyl-CoA hydratase SC10_B2orf04647 ENOG4107Z3H Transcriptional regulator, TetR family SC10_B2orf04648 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf04650 ENOG4105C98 muts2 protein SC10_B2orf04651 ENOG4105DCG PHP domain protein SC10_B2orf04653 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) SC10_B2orf04654 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) SC10_B2orf04659 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) SC10_B2orf04660 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) SC10_B2orf04662 ENOG41067MF small acid-soluble spore protein SC10_B2orf04663 ENOG4108RWN rrna methyltransferase SC10_B2orf04667 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) SC10_B2orf04668 ENOG410905X membrane-flanked domain protein SC10_B2orf04675 ENOG4105DRS transport system, permease SC10_B2orf04679 ENOG4108MDK Dehydrogenase SC10_B2orf04680 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase SC10_B2orf04682 ENOG4105EF1 ribulokinase SC10_B2orf04683 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) SC10_B2orf04684 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase SC10_B2orf04687 ENOG4105CN9 Peptidase m42 family protein SC10_B2orf04690 ENOG410696E Membrane SC10_B2orf04691 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) SC10_B2orf04692 ENOG4105VJV 50s ribosomal protein L35 SC10_B2orf04693 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) SC10_B2orf04695 ENOG41067MG lrgb family SC10_B2orf04698 ENOG4105DGI Alkaline phosphatase SC10_B2orf04700 ENOG4105DY9 regulatoR SC10_B2orf04702 ENOG4108HRK Histidine kinase SC10_B2orf04704 ENOG4105U0R haloacid dehalogenase-like hydrolase SC10_B2orf04707 ENOG4105C22 threonyL-tRNA synthetase SC10_B2orf04709 ENOG4108TDW sporulation protein YtxC SC10_B2orf04714 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) SC10_B2orf04717 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) SC10_B2orf04718 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase SC10_B2orf04721 ENOG4108NR7 pectate lyase SC10_B2orf04722 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) SC10_B2orf04725 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) SC10_B2orf04727 ENOG4105C2M dna polymerase I SC10_B2orf04728 ENOG4105BZU Histidine kinase SC10_B2orf04729 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SC10_B2orf04732 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) SC10_B2orf04733 ENOG4108HMX isocitrate dehydrogenase (NADP) SC10_B2orf04736 ENOG4105BZN citrate synthase SC10_B2orf04737 ENOG4108RZ2 Glycoside hydrolase family 16 SC10_B2orf04740 ENOG4108VMM UPF0756 membrane protein SC10_B2orf04741 ENOG4108REF Sporulation integral membrane protein ytvi SC10_B2orf04744 ENOG4105FS0 cytoplasmic membrane protein SC10_B2orf04746 ENOG4105CA9 Pyruvate kinase SC10_B2orf04747 ENOG4105CTQ phosphohexokinase SC10_B2orf04749 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) SC10_B2orf04754 ENOG4105C6K Malic enzyme SC10_B2orf04756 ENOG4105C0B DNA polymerase III (alpha subunit) SC10_B2orf04757 ENOG4105VV2 SC10_B2orf04759 ENOG4106EVM SC10_B2orf04761 ENOG4105SFS phosphoesterase RecJ domain protein SC10_B2orf04765 ENOG4105U3E Transcriptional regulator SC10_B2orf04766 ENOG4105E8R UPF0173 metal-dependent hydrolase SC10_B2orf04772 ENOG4105CH7 arginosuccinase SC10_B2orf04774 ENOG4105CDH Citrulline--aspartate ligase SC10_B2orf04778 ENOG4105EPU Molybdenum cofactor synthesis domain protein SC10_B2orf04780 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) SC10_B2orf04783 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) SC10_B2orf04785 ENOG4105KBJ sporulation protein ytfj SC10_B2orf04787 ENOG4105VK3 rdd domain containing protein SC10_B2orf04788 ENOG4105D07 Signal peptide peptidase, SppA SC10_B2orf04793 ENOG41061AU MarR family Transcriptional regulator SC10_B2orf04794 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) SC10_B2orf04795 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) SC10_B2orf04802 ENOG4105U5Y Transcriptional regulator SC10_B2orf04804 ENOG4105BZU Histidine kinase SC10_B2orf04805 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) SC10_B2orf04809 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) SC10_B2orf04813 ENOG4105F1V Acetoin utilization protein SC10_B2orf04814 ENOG4105W87 Cbs domain SC10_B2orf04815 ENOG4105DGU Histone deacetylase SC10_B2orf04819 ENOG4105ER2 Ompa motb domain protein SC10_B2orf04820 ENOG4107R0U MotA TolQ exbB proton channel SC10_B2orf04822 ENOG4105ETE Transcriptional regulator (LacI family SC10_B2orf04823 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase SC10_B2orf04831 ENOG4105DFU Cell wall formation (By similarity) SC10_B2orf04834 ENOG4108VDD TRNA binding domain protein SC10_B2orf04837 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ SC10_B2orf04841 ENOG4105C6K Malic enzyme SC10_B2orf04842 ENOG4105C8F Beta-lactamase domain protein SC10_B2orf04844 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) SC10_B2orf04846 ENOG4108V15 phosphotransferase enzyme family SC10_B2orf04848 ENOG4108IUM Glycogen debranching enzyme SC10_B2orf04851 ENOG4107F58 2'-5' rna ligase SC10_B2orf04852 ENOG4105C6T cysteine synthase SC10_B2orf04855 ENOG4107QSE Dipeptidase SC10_B2orf04856 ENOG4105C7N Xanthine uracil vitamin C permease SC10_B2orf04864 ENOG4105CBX hi0933 family SC10_B2orf04866 ENOG4105C94 Transporter SC10_B2orf04869 ENOG41085GJ domain protein SC10_B2orf04875 ENOG4105MU9 integral membrane protein SC10_B2orf04877 ENOG4105DDC Oxidoreductase domain protein SC10_B2orf04881 ENOG4105F5H Glycosyl Hydrolase Family 88 SC10_B2orf04886 ENOG41075H3 AraC family transcriptional regulator SC10_B2orf04889 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component SC10_B2orf04892 ENOG4105NTD Inherit from COG: Hydrolase SC10_B2orf04896 ENOG4107V2S Transcriptional regulator SC10_B2orf04897 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase SC10_B2orf04899 ENOG4105C8T Leucyl-tRNA synthetase SC10_B2orf04904 ENOG410605W Major Facilitator SC10_B2orf04905 ENOG4105D01 (LipO)protein SC10_B2orf04906 ENOG4106UBQ SC10_B2orf04908 ENOG4107R34 abc transporter permease protein SC10_B2orf04909 ENOG4105C19 ABC transporter SC10_B2orf04911 ENOG4105DVE abc transporter atp-binding protein SC10_B2orf04912 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family SC10_B2orf04916 ENOG4105N5T Radical SAM Protein SC10_B2orf04922 ENOG4105E8V Alpha Beta Hydrolase Fold protein SC10_B2orf04923 ENOG4108Z0R Transferase SC10_B2orf04925 ENOG4105YVM Phosphoesterase, PA-phosphatase related SC10_B2orf04926 ENOG4105BZF Glycosyl transferase (Group 1 SC10_B2orf04927 ENOG4105CAQ asparagine synthetase SC10_B2orf04929 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP SC10_B2orf04939 ENOG4105D2X ABC transporter substrate-binding protein SC10_B2orf04942 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component SC10_B2orf04948 ENOG4108RMU ferritin dps family protein SC10_B2orf04952 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) SC10_B2orf04954 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) SC10_B2orf04956 ENOG4108V2W Carbonate dehydratase SC10_B2orf04959 ENOG4105DSE periplasmic solute binding protein SC10_B2orf04969 ENOG4105DTQ mandelate racemase muconate lactonizing SC10_B2orf04971 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf04973 ENOG4108IPT Naphthoate synthase SC10_B2orf04974 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) SC10_B2orf04976 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) SC10_B2orf04977 ENOG4105E4F Isochorismate synthase SC10_B2orf04978 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase SC10_B2orf04982 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) SC10_B2orf04985 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) SC10_B2orf04986 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) SC10_B2orf04995 ENOG4105CMD Transcriptional regulator, GntR family SC10_B2orf04997 ENOG4105N67 Proton-coupled thiamine transporter YuaJ SC10_B2orf05005 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) SC10_B2orf05007 ENOG4105CZN Potassium uptake protein SC10_B2orf05009 ENOG4106DF1 SC10_B2orf05011 ENOG4108VNY MOSC domain protein SC10_B2orf05013 ENOG4108JB8 alcohol dehydrogenase SC10_B2orf05015 ENOG4105C26 Dehydrogenase SC10_B2orf05018 ENOG4105TRT Transcriptional regulator SC10_B2orf05021 ENOG4105JQZ Methyltransferase SC10_B2orf05022 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) SC10_B2orf05025 ENOG4105F0F Oxalate decarboxylase SC10_B2orf05029 ENOG41065RQ ADP-ribosylation crystallin J1 SC10_B2orf05042 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) SC10_B2orf05051 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) SC10_B2orf05056 ENOG4105EE0 oxidoreductase SC10_B2orf05058 ENOG4108Z0Z intracellular protease Pfpi family SC10_B2orf05059 ENOG4105C8Q Methyl-accepting chemotaxis SC10_B2orf05060 ENOG4105C8Q Methyl-accepting chemotaxis SC10_B2orf05061 ENOG4105C8Q Methyl-accepting chemotaxis SC10_B2orf05064 ENOG4105EA8 2-Nitropropane dioxygenase SC10_B2orf05066 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme SC10_B2orf05072 ENOG4105C37 (CBS) domain SC10_B2orf05076 ENOG4107PBV potassium channel SC10_B2orf05079 ENOG4107PBV potassium channel SC10_B2orf05081 ENOG410900G Protein of unknown function (DUF421) SC10_B2orf05084 ENOG4105KNA -acetyltransferase SC10_B2orf05085 ENOG4107QYV phosphohexose isomerase SC10_B2orf05086 ENOG4107QW4 alcohol dehydrogenase SC10_B2orf05087 ENOG4105WG9 Conserved Protein SC10_B2orf05091 ENOG4105CHM Aminotransferase SC10_B2orf05092 ENOG4108ZB6 transcriptional regulator AsnC family SC10_B2orf05094 ENOG4108MUZ hydrolase SC10_B2orf05099 ENOG4105C87 Aminotransferase class I and II SC10_B2orf05102 ENOG4105Y38 Kinase-associated protein B SC10_B2orf05106 ENOG4105BZ4 penicillin-binding protein SC10_B2orf05107 ENOG4105KIR Thiol-disulfide oxidoreductase dcc SC10_B2orf05114 ENOG4108MRH transcriptional regulatory protein SC10_B2orf05117 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase SC10_B2orf05118 ENOG4107ZTW SNARE associated Golgi SC10_B2orf05119 ENOG4105DJ4 phosphatidylserine decarboxylase SC10_B2orf05124 ENOG4105D65 subunit l SC10_B2orf05126 ENOG4105HC0 Na H antiporter SC10_B2orf05127 ENOG4108ZE9 Monovalent cation H antiporter subunit C SC10_B2orf05128 ENOG4108JPZ Monovalent cation H antiporter subunit D SC10_B2orf05130 ENOG4105SC1 monovalent cation H antiporter subunit E SC10_B2orf05133 ENOG4105KJM monovalent cation h antiporter subunit g SC10_B2orf05134 ENOG4105KA0 thioesterase Superfamily protein SC10_B2orf05137 ENOG4105BZU Histidine kinase SC10_B2orf05143 ENOG4105D58 Diguanylate phosphodiesterase SC10_B2orf05144 ENOG4105DAP Nicotinate phosphoribosyltransferase SC10_B2orf05154 ENOG4105C02 permease SC10_B2orf05156 ENOG4108Z40 Transcriptional regulator SC10_B2orf05163 ENOG410904N short-chain dehydrogenase reductase SC10_B2orf05173 ENOG4105BZG amino acid carrier protein SC10_B2orf05174 ENOG4108K8K Transcriptional regulator SC10_B2orf05175 ENOG4105DCF alanine dehydrogenase SC10_B2orf05183 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) SC10_B2orf05185 ENOG41069ER domain protein SC10_B2orf05188 ENOG4105CEP NADH dehydrogenase SC10_B2orf05189 ENOG4105CAY ferredoxin--nadp reductase SC10_B2orf05194 ENOG4108YM7 Gcn5-related n-acetyltransferase SC10_B2orf05198 ENOG4108YX9 iron--sulfur cluster insertion protein erpA SC10_B2orf05205 ENOG4108QY0 Membrane SC10_B2orf05208 ENOG4108ZMX Domain of unknown function (DU1801) SC10_B2orf05216 ENOG4105PY6 Phenolic acid decarboxylase SC10_B2orf05221 ENOG41083MR nifu domain-containing protein SC10_B2orf05224 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein SC10_B2orf05226 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) SC10_B2orf05228 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) SC10_B2orf05229 ENOG4105D6E homoserine dehydrogenase SC10_B2orf05230 ENOG4105C5I Dehydrogenase SC10_B2orf05233 ENOG4108W5N phosphatidylglycerophosphatase a SC10_B2orf05236 ENOG4105D4U had-superfamily hydrolase, subfamily iia SC10_B2orf05239 ENOG4105MMD transcriptional regulator SC10_B2orf05240 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) SC10_B2orf05243 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) SC10_B2orf05244 ENOG4105FAA peptidase M23 SC10_B2orf05247 ENOG4105C8J )-transporter SC10_B2orf05250 ENOG4108YTE sporulation protein YunB SC10_B2orf05252 ENOG4105KZD Domain of unknown function (DUF1805) SC10_B2orf05254 ENOG4107R8B 5'-nucleotidase SC10_B2orf05256 ENOG4105I3N Conserved Protein SC10_B2orf05258 ENOG4105IIP Membrane SC10_B2orf05259 ENOG4105W1N transcriptional regulator SC10_B2orf05261 ENOG4105C5R Aminotransferase SC10_B2orf05262 ENOG4105G9B Transcriptional regulator SC10_B2orf05269 ENOG4108I0Q anthranilate phosphoribosyltransferase SC10_B2orf05271 ENOG4108K8S endonuclease I SC10_B2orf05277 ENOG4107VFR oxidoreductase SC10_B2orf05284 ENOG4105DIW FeS assembly protein SUFB SC10_B2orf05286 ENOG4108UNV SUF system FeS assembly protein, NifU family SC10_B2orf05287 ENOG4105C9B Cysteine desulfurase SC10_B2orf05289 ENOG4105JRK feS assembly protein SufD SC10_B2orf05290 ENOG4105C3K feS assembly ATPase SufC SC10_B2orf05291 ENOG4105PGM cation diffusion facilitator family transporter SC10_B2orf05296 ENOG4105D01 (LipO)protein SC10_B2orf05297 ENOG4108UMI ABC transporter, permease SC10_B2orf05299 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) SC10_B2orf05305 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) SC10_B2orf05306 ENOG41080E8 Transcriptional regulator, Spx MgsR family SC10_B2orf05307 ENOG4105C1G acyl-Coa dehydrogenase SC10_B2orf05308 ENOG4105CHU acetyl-coa acetyltransferase SC10_B2orf05317 ENOG4105E0A ABC, transporter SC10_B2orf05319 ENOG4108IHU transport system permease protein SC10_B2orf05320 ENOG4105DQ5 transport system permease protein SC10_B2orf05321 ENOG4108MES Periplasmic binding protein SC10_B2orf05326 ENOG4105DZ1 carboxypeptidase SC10_B2orf05327 ENOG4105E1F short-chain dehydrogenase reductase SC10_B2orf05328 ENOG4105HUF DNA protection during starvation protein SC10_B2orf05331 ENOG4105C0H protease SC10_B2orf05336 ENOG4105F3H Histidine kinase SC10_B2orf05339 ENOG41067SE Tetr family transcriptional regulator SC10_B2orf05342 ENOG4105C9Q fumarate hydratase class II SC10_B2orf05351 ENOG4105WH1 Two component transcriptional regulator luxr family SC10_B2orf05352 ENOG4105ENE Histidine kinase SC10_B2orf05356 ENOG41087YS Phage shock protein A SC10_B2orf05361 ENOG4108WBT adenosyltransferase SC10_B2orf05362 ENOG4105CHR reductase SC10_B2orf05363 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) SC10_B2orf05365 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) SC10_B2orf05370 ENOG4105C0A alcohol dehydrogenase SC10_B2orf05371 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SC10_B2orf05372 ENOG4105E0A ABC, transporter SC10_B2orf05373 ENOG4105EHG Permease protein SC10_B2orf05375 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) SC10_B2orf05376 ENOG4105DRR Transcriptional regulator, GntR family SC10_B2orf05377 ENOG4105EWI Short-chain dehydrogenase reductase Sdr SC10_B2orf05379 ENOG4108RPX mosc domain containing protein SC10_B2orf05380 ENOG4107RSM transcriptional regulator SC10_B2orf05384 ENOG4105CTX dehydratase SC10_B2orf05385 ENOG4107QZW Altronate oxidoreductase SC10_B2orf05386 ENOG4107KJX Transcriptional regulator SC10_B2orf05387 ENOG4105CT4 transporter SC10_B2orf05388 ENOG4105D2H Uronic isomerase SC10_B2orf05392 ENOG4105DPZ Two component transcriptional regulator (Winged helix family SC10_B2orf05393 ENOG4105E0A ABC, transporter SC10_B2orf05394 ENOG4105EHG Permease protein SC10_B2orf05395 ENOG4105DQ5 transport system permease protein SC10_B2orf05396 ENOG4105D5Q Arginine ornithine antiporter SC10_B2orf05400 ENOG4107K5X Membrane-bound metal-dependent hydrolase SC10_B2orf05401 ENOG4107QZ2 Sulfatase SC10_B2orf05407 ENOG4105EVU fructokinase SC10_B2orf05409 ENOG4107EPV Aminotransferase class V SC10_B2orf05413 ENOG4108WC5 Alpha Beta Hydrolase Fold protein SC10_B2orf05414 ENOG4105EEM helicase SC10_B2orf05416 ENOG4105EN6 Membrane SC10_B2orf05417 ENOG4105RHY Pfam:UPF0157 SC10_B2orf05418 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) SC10_B2orf05425 ENOG4107ZQN disulfide bond SC10_B2orf05426 ENOG4105C59 p-type ATPase SC10_B2orf05430 ENOG4108JE9 extracellular solute-binding protein family 1 SC10_B2orf05431 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component SC10_B2orf05433 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component SC10_B2orf05434 ENOG4105CJQ hydrolase, family 31 SC10_B2orf05436 ENOG4105DIK (ABC) transporter SC10_B2orf05437 ENOG4105CC5 ABC transporter SC10_B2orf05439 ENOG4105DSE periplasmic solute binding protein SC10_B2orf05444 ENOG4105HX0 Transcriptional regulator SC10_B2orf05446 ENOG4105DM4 PTS System SC10_B2orf05447 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN SC10_B2orf05453 ENOG4105C59 p-type ATPase SC10_B2orf05454 ENOG410681U heavy metal transport detoxification protein SC10_B2orf05455 ENOG4105VPX protein, conserved in bacteria SC10_B2orf05456 ENOG4107RKG DJ-1/PfpI family SC10_B2orf05457 ENOG4105E98 transcriptional regulator DeoR family SC10_B2orf05459 ENOG4105DET Rhamnulokinase SC10_B2orf05461 ENOG4105C9F isomerase SC10_B2orf05466 ENOG4105F27 Major Facilitator SC10_B2orf05471 ENOG410625E SC10_B2orf05474 ENOG4106A3M Cytochrome p-450 SC10_B2orf05480 ENOG4105D9R oxidoreductase SC10_B2orf05486 ENOG4105C72 UPF0176 protein SC10_B2orf05489 ENOG4106DF4 Sigma-70, region 4 SC10_B2orf05493 ENOG4105F0F Oxalate decarboxylase SC10_B2orf05499 ENOG4108MYR Secreted protein SC10_B2orf05500 ENOG4107SYN Glycosyl hydrolases family 43 SC10_B2orf05507 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) SC10_B2orf05512 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) SC10_B2orf05515 ENOG4105XZU Preprotein translocase, subunit SecG SC10_B2orf05523 ENOG4105R40 Glycine betaine carnitine choline SC10_B2orf05524 ENOG4108HQR Glycine betaine SC10_B2orf05526 ENOG4105E90 ABC transporter SC10_B2orf05527 ENOG4108IJ8 ABC transporter SC10_B2orf05528 ENOG4107HG4 Transcriptional regulator SC10_B2orf05529 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein SC10_B2orf05532 ENOG4105T65 Membrane-associated protein SC10_B2orf05533 ENOG4108MES Periplasmic binding protein SC10_B2orf05538 ENOG4108V4B ThiJ pfpI SC10_B2orf05540 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) SC10_B2orf05542 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) SC10_B2orf05543 ENOG4105CP7 Triose-phosphate isomerase SC10_B2orf05545 ENOG4105BZA Phosphoglycerate kinase SC10_B2orf05547 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase SC10_B2orf05550 ENOG4105DEN Luciferase family SC10_B2orf05558 ENOG4105CIG ABC transporter SC10_B2orf05564 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) SC10_B2orf05566 ENOG4105JXH GntR family transcriptional regulator SC10_B2orf05568 ENOG4105DAA L-lactate SC10_B2orf05569 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) SC10_B2orf05571 ENOG4108ZPC Polysaccharide pyruvyl transferase SC10_B2orf05572 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase SC10_B2orf05573 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family SC10_B2orf05575 ENOG4105D3Q Sugar transferase SC10_B2orf05578 ENOG4105K64 Glycosyl transferase, family 2 SC10_B2orf05581 ENOG4107QRS glycosyltransferase group 2 family protein SC10_B2orf05582 ENOG41068W6 Capsular polysaccharide biosynthesis protein SC10_B2orf05583 ENOG4108KMV Glycosyl transferase (Group 1 SC10_B2orf05584 ENOG4105K64 Glycosyl transferase, family 2 SC10_B2orf05585 ENOG4108PQP glycosyl transferase group 1 SC10_B2orf05588 ENOG4108QV3 biosynthesis protein SC10_B2orf05589 ENOG4105HTX biosynthesis protein SC10_B2orf05594 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein SC10_B2orf05595 ENOG4108I5G Major Facilitator superfamily SC10_B2orf05598 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) SC10_B2orf05600 ENOG4107S2N Type III effector Hrp-dependent SC10_B2orf05601 ENOG4105C0A alcohol dehydrogenase SC10_B2orf05602 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) SC10_B2orf05603 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family SC10_B2orf05605 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase SC10_B2orf05606 ENOG4105EDQ levansucrase EC 2.4.1.10 SC10_B2orf05607 ENOG4108HKT sucrose-6-phosphate hydrolase SC10_B2orf05610 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) SC10_B2orf05611 ENOG4108URH decarboxylase SC10_B2orf05612 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain SC10_B2orf05613 ENOG4107TVP HD domain protein SC10_B2orf05614 ENOG4105CHH sulfate transporter SC10_B2orf05615 ENOG4108V2W Carbonate dehydratase SC10_B2orf05617 ENOG4105C5I Dehydrogenase SC10_B2orf05618 ENOG4108SQ9 flavin reductase domain protein, FMN-binding SC10_B2orf05619 ENOG4108ZHR arsR family transcriptional regulator SC10_B2orf05621 ENOG4105GGE ribonuclease SC10_B2orf05624 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase SC10_B2orf05625 ENOG4105KRI phosphocarrier protein (HPr SC10_B2orf05626 ENOG4105CIE May be required for sporulation (By similarity) SC10_B2orf05627 ENOG4105CHW UPF0052 protein SC10_B2orf05628 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) SC10_B2orf05629 ENOG4108Z4K mutator MutT protein SC10_B2orf05632 ENOG4105C3M thioredoxin reductase SC10_B2orf05636 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase SC10_B2orf05637 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) SC10_B2orf05638 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase SC10_B2orf05639 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) SC10_B2orf05642 ENOG4105ECC imidazole-glycerol-phosphate dehydratase SC10_B2orf05643 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) SC10_B2orf05644 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) SC10_B2orf05645 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) SC10_B2orf05647 ENOG4108E16 pectate lyase SC10_B2orf05649 ENOG4108S4C acetyltransferase SC10_B2orf05650 ENOG4107XGZ Hydrolase SC10_B2orf05651 ENOG4105HKU nucleoside recognition domain-containing protein SC10_B2orf05653 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) SC10_B2orf05654 ENOG410834F Transcriptional regulator SC10_B2orf05656 ENOG4105C0R drug resistance transporter emrb qaca subfamily SC10_B2orf05658 ENOG41088CQ domain protein SC10_B2orf05659 ENOG41086DT Membrane protein of unknown function SC10_B2orf05660 ENOG41067S9 phage shock protein C, PspC SC10_B2orf05661 ENOG4108PY7 SC10_B2orf05665 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase SC10_B2orf05666 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) SC10_B2orf05667 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) SC10_B2orf05675 ENOG4105CN1 protease SC10_B2orf05677 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) SC10_B2orf05680 ENOG4105Z8B NlpC/P60 family SC10_B2orf05681 ENOG4105CRP Part of the ABC transporter FtsEX involved in SC10_B2orf05682 ENOG4105CAK Cell division ATP-binding protein ftsE SC10_B2orf05687 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) SC10_B2orf05690 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving SC10_B2orf05692 ENOG4105MS2 ribosomal subunit Interface protein SC10_B2orf05695 ENOG4105MQ3 flagellar protein FliS SC10_B2orf05696 ENOG4107RT6 flagellar hook-associated SC10_B2orf05697 ENOG41083S7 flagellar protein FlaG SC10_B2orf05698 ENOG4105I03 Flagellin SC10_B2orf05700 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) SC10_B2orf05701 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) SC10_B2orf05702 ENOG4105MKD SC10_B2orf05704 ENOG4105DTJ flagellar hook-associated protein SC10_B2orf05705 ENOG4105E1Q flagellar hook-associated protein SC10_B2orf05709 ENOG4105RU3 SC10_B2orf05710 ENOG41081UC Inherit from COG: Competence protein SC10_B2orf05717 ENOG4105WH1 Two component transcriptional regulator luxr family SC10_B2orf05718 ENOG4105BZU Histidine kinase SC10_B2orf05719 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein SC10_B2orf05720 ENOG4108KGH TRANSCRIPTIONal SC10_B2orf05722 ENOG4105ESV Glycosyl transferase, family 4 SC10_B2orf05723 ENOG4107EF8 Glycosyl transferase (Group 1 SC10_B2orf05727 ENOG4105QZI O-Antigen Polymerase SC10_B2orf05729 ENOG4105C1B dTDP-glucose 4-6-dehydratase SC10_B2orf05730 ENOG4105C6Y Udp-glucose 6-dehydrogenase SC10_B2orf05731 ENOG4107RA4 Glycosyl transferase (Group 1 SC10_B2orf05732 ENOG4105PSV Polysaccharide Biosynthesis Protein SC10_B2orf05733 ENOG4105D3Q Sugar transferase SC10_B2orf05734 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase SC10_B2orf05738 ENOG4108KGH TRANSCRIPTIONal SC10_B2orf05739 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase SC10_B2orf05740 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase SC10_B2orf05741 ENOG4107RZX Teichoic acid biosynthesis protein SC10_B2orf05743 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase SC10_B2orf05744 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) SC10_B2orf05745 ENOG4107SJB teichoic acid biosynthesis SC10_B2orf05747 ENOG4107SJB teichoic acid biosynthesis SC10_B2orf05750 ENOG4105EY8 ABC transporter SC10_B2orf05758 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase SC10_B2orf05760 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) SC10_B2orf05764 ENOG4105DG6 mannose-6-phosphate isomerase SC10_B2orf05767 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase SC10_B2orf05768 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) SC10_B2orf05770 ENOG4108UHU Aldolase SC10_B2orf05771 ENOG4105D7K pfkb domain protein SC10_B2orf05772 ENOG4108M60 Transcriptional regulator SC10_B2orf05777 ENOG4105CHR reductase SC10_B2orf05778 ENOG4105E2A Dehydrogenase SC10_B2orf05782 ENOG4105C54 Major Facilitator superfamily SC10_B2orf05783 ENOG4108KGH TRANSCRIPTIONal SC10_B2orf05785 ENOG4105J7I hydrolase SC10_B2orf05786 ENOG4105K4H Nlp p60 protein SC10_B2orf05790 ENOG4105PNM synthesis protein SC10_B2orf05792 ENOG4105N98 Capsule biosynthesis protein capB SC10_B2orf05793 ENOG4105ETE Transcriptional regulator (LacI family SC10_B2orf05795 ENOG4108RVA ribokinase SC10_B2orf05798 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) SC10_B2orf05799 ENOG4105C2J ABC transporter SC10_B2orf05800 ENOG4105CNN ABC, transporter SC10_B2orf05801 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator SC10_B2orf05802 ENOG4105C5Q Transcriptional regulator SC10_B2orf05803 ENOG41089UC methyltransferase, type 11 SC10_B2orf05806 ENOG4107FQX Alpha-acetolactate decarboxylase SC10_B2orf05808 ENOG4107RSM transcriptional regulator SC10_B2orf05809 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) SC10_B2orf05811 ENOG4105CAH Chromate SC10_B2orf05812 ENOG4105FGV Chromate SC10_B2orf05814 ENOG4108RB3 Capsular polysaccharide biosynthesis protein SC10_B2orf05815 ENOG4105HTX biosynthesis protein SC10_B2orf05818 ENOG4105KBK Zinc finger, swim domain protein SC10_B2orf05819 ENOG4105C0D helicase SC10_B2orf05820 ENOG4108XI2 Domain of unknown function (DUF1963) SC10_B2orf05821 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) SC10_B2orf05825 ENOG410667J hydrolase SC10_B2orf05827 ENOG4105E98 transcriptional regulator DeoR family SC10_B2orf05828 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) SC10_B2orf05829 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase SC10_B2orf05832 ENOG4105VI0 Pts system, glucitol sorbitol-specific SC10_B2orf05833 ENOG4105DZY Pts system, glucitol sorbitol-specific SC10_B2orf05834 ENOG410787A Pts system, glucitol sorbitol-specific SC10_B2orf05836 ENOG4105DKT Transcriptional regulator SC10_B2orf05838 ENOG4105Z8H single-stranded DNA-binding protein SC10_B2orf05843 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) SC10_B2orf05845 ENOG4105CGA flagellar basal-body rod protein FlgG SC10_B2orf05849 ENOG4105DFF Rod shape-determining protein mreb SC10_B2orf05850 ENOG4105MT0 Sporulation transcriptional regulator spoiiid SC10_B2orf05851 ENOG4107MII Sugar-specific transcriptional regulator TrmB SC10_B2orf05852 ENOG4105CZM Major Facilitator SC10_B2orf05855 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase SC10_B2orf05856 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase SC10_B2orf05859 ENOG4108NA0 Uncharacterized conserved protein (COG2071) SC10_B2orf05862 ENOG41080XP Cbs domain SC10_B2orf05864 ENOG4105C37 (CBS) domain SC10_B2orf05867 ENOG4105BZU Histidine kinase SC10_B2orf05872 ENOG4105FRN stage II sporulation protein SC10_B2orf05876 ENOG4107TCE N-acetyltransferase SC10_B2orf05878 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) SC10_B2orf05880 ENOG4105C0R drug resistance transporter emrb qaca subfamily SC10_B2orf05881 ENOG4105WQT MbtH domain protein SC10_B2orf05884 ENOG4105CEY Amp-dependent synthetase and ligase SC10_B2orf05885 ENOG4105WQI isochorismatase SC10_B2orf05886 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase SC10_B2orf05887 ENOG4105E4F Isochorismate synthase SC10_B2orf05888 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase SC10_B2orf05891 ENOG4105NIV Esterase SC10_B2orf05896 ENOG410874W AraC family transcriptional regulator SC10_B2orf05901 ENOG4108RYK Nad-dependent epimerase dehydratase SC10_B2orf05902 ENOG4108Z40 Transcriptional regulator SC10_B2orf05908 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) SC10_B2orf05909 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) SC10_B2orf05911 ENOG4105FCD Major Facilitator SC10_B2orf05915 ENOG4108HIZ formate dehydrogenase alpha subunit SC10_B2orf05916 ENOG4108TF4 von Willebrand factor, type A SC10_B2orf05923 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) SC10_B2orf05925 ENOG4106778 Protein of unknown function (DUF1146) SC10_B2orf05926 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) SC10_B2orf05927 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) SC10_B2orf05928 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) SC10_B2orf05929 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) SC10_B2orf05930 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) SC10_B2orf05933 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) SC10_B2orf05935 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) SC10_B2orf05936 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) SC10_B2orf05937 ENOG4108UIC UPF0340 protein SC10_B2orf05938 ENOG4108YZG isomerase SC10_B2orf05939 ENOG4107WAU Protein tyrosine phosphatase SC10_B2orf05941 ENOG410815N Probably functions as a manganese efflux pump (By similarity) SC10_B2orf05942 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) SC10_B2orf05945 ENOG4108ZXQ stage ii sporulation protein r SC10_B2orf05950 ENOG4105TRI Hydrolase SC10_B2orf05955 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) SC10_B2orf05956 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) SC10_B2orf05957 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase SC10_B2orf05961 ENOG4107TT2 Auxin Efflux Carrier SC10_B2orf05963 ENOG4105C6K Malic enzyme SC10_B2orf05965 ENOG4107104 thymidine kinase SC10_B2orf05968 ENOG41082DI 50s ribosomal protein l31 SC10_B2orf05969 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) SC10_B2orf05970 ENOG4105CBT Fructose-1,6-bisphosphatase SC10_B2orf05971 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) SC10_B2orf05972 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway SC10_B2orf05974 ENOG4105D2N Aldolase SC10_B2orf05975 ENOG410812K response regulator receiver protein SC10_B2orf05978 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) SC10_B2orf05985 ENOG4105C1G acyl-Coa dehydrogenase SC10_B2orf05986 ENOG4105C1G acyl-Coa dehydrogenase SC10_B2orf05988 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase SC10_B2orf05991 ENOG4105DF6 Fe-S oxidoreductase SC10_B2orf05996 ENOG4105C75 arginyL-tRNA synthetase SC10_B2orf05997 ENOG410684U Domain of unknown function (DUF1934) SC10_B2orf05998 ENOG4105CYW agmatinase SC10_B2orf06000 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) SC10_B2orf06001 ENOG4105BZ4 penicillin-binding protein SC10_B2orf06003 ENOG4108XFG YwhD family SC10_B2orf06005 ENOG4108Z4T Peptidase M50 SC10_B2orf06006 ENOG41069HH 4-oxalocrotonate tautomerase SC10_B2orf06010 ENOG4105DCI Phosphohydrolase SC10_B2orf06013 ENOG4108VCI transcription factor, rsfa family SC10_B2orf06018 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) SC10_B2orf06021 ENOG4105D2S major facilitator superfamily SC10_B2orf06028 ENOG4108FUF Transcriptional regulator, IclR family SC10_B2orf06030 ENOG4108IJ2 phosphate acetyltransferase SC10_B2orf06031 ENOG4107JTW chlorite dismutase SC10_B2orf06036 ENOG4105CZN Potassium uptake protein SC10_B2orf06042 ENOG4105CJ1 ABC, transporter SC10_B2orf06053 ENOG4105C26 Dehydrogenase SC10_B2orf06055 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) SC10_B2orf06056 ENOG4108RJ9 Glycosyl transferase, family 2 SC10_B2orf06057 ENOG4105DWF phosphomethylpyrimidine kinase SC10_B2orf06063 ENOG4105C5Y PTS System SC10_B2orf06067 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin SC10_B2orf06070 ENOG4105DEN Luciferase family SC10_B2orf06072 ENOG4108DBC nitroreductase SC10_B2orf06077 ENOG4105DWD nucleoside recognition domain protein SC10_B2orf06095 ENOG41060D1 Quinol oxidase SC10_B2orf06097 ENOG4105BZ9 Cytochrome C oxidase, subunit I SC10_B2orf06098 ENOG4105E2S oxidase) subunit II SC10_B2orf06100 ENOG4105CMR udp-glucose 4-epimerase SC10_B2orf06103 ENOG4108WS4 fmn reductase SC10_B2orf06107 ENOG4105CMG Carbohydrate kinase SC10_B2orf06109 ENOG4105C93 Xylose Isomerase SC10_B2orf06111 ENOG4105E2R ROK family SC10_B2orf06112 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) SC10_B2orf06113 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase SC10_B2orf06115 ENOG4105CMU LysR family (Transcriptional regulator SC10_B2orf06120 ENOG41067MG lrgb family SC10_B2orf06124 ENOG4105CK7 Sodium proline symporter SC10_B2orf06125 ENOG4105DR4 Methyltransferase SC10_B2orf06128 ENOG4105C5I Dehydrogenase SC10_B2orf06129 ENOG4105X1N Glycosyl transferase family 8 SC10_B2orf06133 ENOG4105ENE Histidine kinase SC10_B2orf06134 ENOG4108VB1 regulatoR SC10_B2orf06135 ENOG4105EYF MMPL domain protein SC10_B2orf06139 ENOG4105DJB Major Facilitator Superfamily SC10_B2orf06141 ENOG4105CXK mandelate racemase muconate lactonizing SC10_B2orf06143 ENOG4108UHU Aldolase SC10_B2orf06145 ENOG4105D7K pfkb domain protein SC10_B2orf06148 ENOG4105IIU Aminopeptidase SC10_B2orf06150 ENOG41080V3 Major Facilitator superfamily SC10_B2orf06160 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) SC10_B2orf06161 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein SC10_B2orf06162 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) SC10_B2orf06163 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD SC10_B2orf06164 ENOG4105CM2 brancheD-chain amino acid aminotransferase SC10_B2orf06167 ENOG4105F8D glycoside hydrolase family 4 SC10_B2orf06168 ENOG4105VCP PTS System SC10_B2orf06170 ENOG4105CK1 PTS System SC10_B2orf06171 ENOG4105VZJ PTS System SC10_B2orf06173 ENOG4105EMD TRANSCRIPTIONal SC10_B2orf06175 ENOG4108VX5 3-methyladenine DNA glycosylase SC10_B2orf06181 ENOG4105DXD 2-methylcitrate dehydratase SC10_B2orf06182 ENOG4105CR4 methylisocitrate lyase SC10_B2orf06187 ENOG4105BZ1 (ABC) transporter SC10_B2orf06188 ENOG4107TDE lipolytic protein G-D-S-L family SC10_B2orf06195 ENOG4105C2C drug resistance transporter, Bcr CflA SC10_B2orf06197 ENOG4105DA5 (ABC) transporter SC10_B2orf06198 ENOG41069JR SC10_B2orf06210 ENOG4105CH6 catalase SC10_B2orf06213 ENOG4105G5W regulator Fur family SC10_B2orf06214 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) SC10_B2orf06216 ENOG4108J20 pectate lyase SC10_B2orf06218 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) SC10_B2orf06220 ENOG4108JJ8 (ABC) transporter SC10_B2orf06221 ENOG4108JJ9 ABC, transporter SC10_B2orf06222 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii SC10_B2orf06223 ENOG4105C4M (Ubiquinol oxidase) subunit I SC10_B2orf06227 ENOG4108QTI )-transporter SC10_B2orf06231 ENOG4105DFD Na H antiporter SC10_B2orf06232 ENOG4108IJ0 Aspartate ammonia-lyase SC10_B2orf06234 ENOG4105HDK L-asparaginase SC10_B2orf06235 ENOG4108IMY Transcriptional regulator SC10_B2orf06237 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) SC10_B2orf06249 ENOG4107BJW polysaccharide deacetylase SC10_B2orf06251 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family SC10_B2orf06253 ENOG4107QZ7 Cellulose synthase catalytic subunit SC10_B2orf06254 ENOG4105D2K citrate carrier protein SC10_B2orf06255 ENOG4108QXE glycerophosphoryl diester phosphodiesterase SC10_B2orf06257 ENOG4105X3H Excalibur domain protein SC10_B2orf06260 ENOG4105E0M Sulfatase SC10_B2orf06262 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) SC10_B2orf06266 ENOG4105CEU Arginine dihydrolase SC10_B2orf06267 ENOG4105DBV ornithine carbamoyltransferase SC10_B2orf06269 ENOG4105C5B carbamate kinase SC10_B2orf06271 ENOG4105CS2 ec 3.2.1.21 SC10_B2orf06272 ENOG4105CK1 PTS System SC10_B2orf06275 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) SC10_B2orf06278 ENOG4108HKT sucrose-6-phosphate hydrolase SC10_B2orf06279 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) SC10_B2orf06280 ENOG4105DRS transport system, permease SC10_B2orf06281 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component SC10_B2orf06284 ENOG4105ETE Transcriptional regulator (LacI family SC10_B2orf06291 ENOG4105EDW glycosyl transferase, family 39 SC10_B2orf06292 ENOG4105CKK Glycosyl transferase, family 2 SC10_B2orf06294 ENOG4105CMR udp-glucose 4-epimerase SC10_B2orf06306 ENOG4105CH6 catalase SC10_B2orf06308 ENOG4105CS2 ec 3.2.1.21 SC10_B2orf06309 ENOG4105C5Y PTS System SC10_B2orf06310 ENOG4105CID antiterminator SC10_B2orf06313 ENOG4108W7F transporter, permease SC10_B2orf06315 ENOG4108JJB ABC transporter SC10_B2orf06316 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein SC10_B2orf06318 ENOG4105ETU transcriptional activator (TenA SC10_B2orf06322 ENOG4107QP3 malate synthase g SC10_B2orf06326 ENOG4105EDW glycosyl transferase, family 39 SC10_B2orf06329 ENOG4105C19 ABC transporter SC10_B2orf06331 ENOG4105EWM Histidine kinase SC10_B2orf06333 ENOG4105CS2 ec 3.2.1.21 SC10_B2orf06335 ENOG4105C5Y PTS System SC10_B2orf06338 ENOG4107QHE Choloylglycine hydrolase SC10_B2orf06339 ENOG4106Z5D Glycoside Hydrolase Family 43 SC10_B2orf06341 ENOG4105C1J atp-dependent rna helicase SC10_B2orf06350 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) SC10_B2orf06351 ENOG4105D9N nucleoside SC10_B2orf06352 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) SC10_B2orf06353 ENOG4107RHR regulatoR SC10_B2orf06360 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) SC10_B2orf06361 ENOG4107R8N Glycosyl transferase, family 2 SC10_B2orf06364 ENOG4105JKW Valine--pyruvate aminotransferase SC10_B2orf06371 ENOG4105D2N Aldolase SC10_B2orf06373 ENOG4107TRN Xylose isomerase domain protein TIM barrel SC10_B2orf06374 ENOG4105F0H myo-inositol catabolism protein SC10_B2orf06375 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) SC10_B2orf06378 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) SC10_B2orf06380 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) SC10_B2orf06381 ENOG4105D7K pfkb domain protein SC10_B2orf06383 ENOG4105DH8 myo-inositol catabolism SC10_B2orf06384 ENOG4105C26 Dehydrogenase SC10_B2orf06389 ENOG4105CPC Aldo Keto reductase SC10_B2orf06390 ENOG4107VXM glycerophosphoryl diester phosphodiesterase SC10_B2orf06391 ENOG4105CXY transporter SC10_B2orf06392 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) SC10_B2orf06393 ENOG4105C5H ABC transporter SC10_B2orf06394 ENOG410667J hydrolase SC10_B2orf06398 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) SC10_B2orf06401 ENOG4108V5C ABC transporter SC10_B2orf06411 ENOG4105H93 Acyltransferase family SC10_B2orf06420 ENOG4105EC8 Methyl-accepting chemotaxis SC10_B2orf06424 ENOG4105BZG amino acid carrier protein SC10_B2orf06425 ENOG4105DCF alanine dehydrogenase SC10_B2orf06430 ENOG4105EG2 ABC transporter, permease SC10_B2orf06434 ENOG4107FKK extracellular solute-binding protein family 1 SC10_B2orf06437 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) SC10_B2orf06438 ENOG4105CMR udp-glucose 4-epimerase SC10_B2orf06439 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase SC10_B2orf06441 ENOG4105E2R ROK family SC10_B2orf06443 ENOG41082J7 Rhodanese domain protein SC10_B2orf06449 ENOG4105CMG Carbohydrate kinase SC10_B2orf06453 ENOG4108EKI Dehydrogenase SC10_B2orf06454 ENOG4105D3R alkyl hydroperoxide reductase SC10_B2orf06455 ENOG4108JU3 Alkyl hydroperoxide reductase SC10_B2orf06458 ENOG4105C85 amino acid SC10_B2orf06460 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 SC10_B2orf06461 ENOG4108JU3 Alkyl hydroperoxide reductase SC10_B2orf06462 ENOG41065SU Two-component system sensor kinase SC10_B2orf06465 ENOG4105DQ5 transport system permease protein SC10_B2orf06466 ENOG4105EHG Permease protein SC10_B2orf06469 ENOG4108M15 ABC transporter SC10_B2orf06470 ENOG4105KCT ABC transporter SC10_B2orf06471 ENOG4105BZU Histidine kinase SC10_B2orf06474 ENOG4108MIB SC10_B2orf06475 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) SC10_B2orf06479 ENOG4105WQG acetyltransferase SC10_B2orf06489 ENOG4105C0H protease SC10_B2orf06490 ENOG4105Q2H domain protein SC10_B2orf06494 ENOG4105BZU Histidine kinase SC10_B2orf06495 ENOG4105CK6 Two component transcriptional regulator (Winged helix family SC10_B2orf06498 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis SC10_B2orf06502 ENOG4105CDU Replicative dna helicase SC10_B2orf06508 ENOG4105DJ2 Major Facilitator Superfamily SC10_B2orf06509 ENOG4105CE4 GlcNAc 6-P deacetylase SC10_B2orf06510 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) SC10_B2orf06512 ENOG4105FDP GntR family transcriptional regulator SC10_B2orf06513 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate SC10_B2orf06516 ENOG4105K9Q Binds to the 23S rRNA (By similarity) SC10_B2orf06518 ENOG4105BZR domain protein SC10_B2orf06519 ENOG4108XMW Membrane SC10_B2orf06523 ENOG4107YZX Universal stress protein SC10_B2orf06525 ENOG4105CHH sulfate transporter SC10_B2orf06530 ENOG4108UUM single-stranded DNA-binding protein SC10_B2orf06531 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) SC10_B2orf06532 ENOG4105C3G gtp-binding protein SC10_B2orf06534 ENOG4105VDK protein, conserved in bacteria SC10_B2orf06537 ENOG4108ZDA Sporulation protein YyaC SC10_B2orf06539 ENOG4105FA0 parb-like partition protein SC10_B2orf06540 ENOG4107QJE Chromosome Partitioning Protein SC10_B2orf06542 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) SC10_B2orf06544 ENOG4108KPJ rna polymerase sigma factor SC10_B2orf06545 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) SC10_B2orf06548 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) SC10_B2orf06550 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) SC10_B2orf06554 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)