locus-tag	class	description
D2B33_00010	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D2B33_00015	COG0009	L-threonylcarbamoyladenylate synthase
D2B33_00020	COG1971	Probably functions as a manganese efflux pump
D2B33_00025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2B33_00030	COG0698	ribose 5-phosphate isomerase
D2B33_00035	COG4475	Protein of unknown function (DUF436)
D2B33_00040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D2B33_00045	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D2B33_00060	COG0356	it plays a direct role in the translocation of protons across the membrane
D2B33_00065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D2B33_00070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D2B33_00075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D2B33_00080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D2B33_00085	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D2B33_00090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D2B33_00095	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D2B33_00100	COG4836	Membrane
D2B33_00110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2B33_00115	COG2385	sporulation resulting in formation of a cellular spore
D2B33_00120	COG2304	oxidoreductase activity
D2B33_00125	COG2304	oxidoreductase activity
D2B33_00130	COG3383	formate dehydrogenase (NAD+) activity
D2B33_00140	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D2B33_00145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D2B33_00150	COG1994	Peptidase M50
D2B33_00160	COG1959	2 iron, 2 sulfur cluster binding
D2B33_00170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_00185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_00185	COG2207	Transcriptional regulator
D2B33_00190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_00195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_00200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_00205	COG2819	hydrolase of the alpha beta superfamily
D2B33_00210	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_00215	COG1169	isochorismate synthase
D2B33_00220	COG1021	2,3-dihydroxybenzoate-AMP ligase
D2B33_00225	COG1535	isochorismatase
D2B33_00225	COG3433	isochorismatase activity
D2B33_00230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_00235	COG3251	PFAM MbtH domain protein
D2B33_00240	COG0477	Major facilitator Superfamily
D2B33_00245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2B33_00255	COG1247	-acetyltransferase
D2B33_00260	COG0739	heme binding
D2B33_00270	COG0740	serine-type endopeptidase activity
D2B33_00280	COG0347	Belongs to the P(II) protein family
D2B33_00290	COG1253	flavin adenine dinucleotide binding
D2B33_00295	COG0598	Magnesium transport protein CorA
D2B33_00300	COG0517	IMP dehydrogenase activity
D2B33_00315	COG3361	conserved protein (COG2071)
D2B33_00320	COG3546	catalase activity
D2B33_00325	COG1227	inorganic diphosphatase activity
D2B33_00330	COG0671	phosphoesterase, PA-phosphatase related
D2B33_00335	COG2814	Major facilitator Superfamily
D2B33_00340	COG1846	Transcriptional regulator
D2B33_00350	COG1609	Transcriptional regulator
D2B33_00355	COG1077	Cell shape determining protein MreB Mrl
D2B33_00360	COG4786	Flagellar basal body rod
D2B33_00365	COG4786	Flagellar basal body rod
D2B33_00370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D2B33_00375	COG1970	mechanosensitive ion channel activity
D2B33_00390	COG0629	single-stranded DNA binding
D2B33_00410	COG3732	PTS system glucitol sorbitol-specific
D2B33_00420	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_00430	COG1349	DNA-binding transcription factor activity
D2B33_00435	COG0561	phosphatase activity
D2B33_00450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D2B33_00455	COG3878	Protein conserved in bacteria
D2B33_00465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2B33_00470	COG4715	Zinc finger, swim domain protein
D2B33_00480	COG3944	biosynthesis protein
D2B33_00485	COG4464	protein tyrosine phosphatase activity
D2B33_00490	COG2059	Chromate
D2B33_00495	COG2059	Chromate
D2B33_00500	COG1522	sequence-specific DNA binding
D2B33_00505	COG0405	Gamma-glutamyltransferase
D2B33_00510	COG0583	DNA-binding transcription factor activity
D2B33_00515	COG0028	Belongs to the TPP enzyme family
D2B33_00520	COG3527	Alpha-acetolactate decarboxylase
D2B33_00525	COG2226	methyltransferase
D2B33_00530	COG0583	DNA-binding transcription factor activity
D2B33_00535	COG1879	ABC-type sugar transport system periplasmic component
D2B33_00540	COG1172	Belongs to the binding-protein-dependent transport system permease family
D2B33_00550	COG1869	D-ribose catabolic process
D2B33_00555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_00560	COG1609	Transcriptional regulator
D2B33_00565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D2B33_00575	COG2843	Capsule synthesis protein
D2B33_00580	COG0791	NLP P60 protein
D2B33_00585	COG0561	phosphatase activity
D2B33_00590	COG1316	TRANSCRIPTIONal
D2B33_00595	COG2814	Major facilitator Superfamily
D2B33_00600	COG1063	alcohol dehydrogenase
D2B33_00605	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_00610	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D2B33_00615	COG1609	Transcriptional regulator
D2B33_00620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_00625	COG0800	Aldolase
D2B33_00645	COG1482	cell wall glycoprotein biosynthetic process
D2B33_00650	COG4193	domain, Protein
D2B33_00655	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_00660	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
D2B33_00665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D2B33_00670	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_00675	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_00675	COG0463	Glycosyl transferase, family 2
D2B33_00680	COG1682	transport, permease protein
D2B33_00685	COG1134	teichoic acid transport
D2B33_00705	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D2B33_00725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2B33_00730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D2B33_00740	COG1316	TRANSCRIPTIONal
D2B33_00750	COG2385	sporulation resulting in formation of a cellular spore
D2B33_00750	COG2247	cell wall binding repeat
D2B33_00755	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_00755	COG2247	cell wall binding repeat
D2B33_00765	COG2244	polysaccharide biosynthetic process
D2B33_00770	COG0297	glycogen (starch) synthase activity
D2B33_00770	COG0438	transferase activity, transferring glycosyl groups
D2B33_00775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D2B33_00780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2B33_00785	COG3307	-O-antigen
D2B33_00790	COG3206	protein involved in exopolysaccharide biosynthesis
D2B33_00795	COG1215	transferase activity, transferring glycosyl groups
D2B33_00800	COG0438	transferase activity, transferring glycosyl groups
D2B33_00805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2B33_00815	COG1316	TRANSCRIPTIONal
D2B33_00820	COG1739	Uncharacterized protein family UPF0029
D2B33_00825	COG4585	Histidine kinase
D2B33_00830	COG2197	response regulator
D2B33_00835	COG1307	EDD domain protein, DegV family
D2B33_00840	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D2B33_00850	COG1040	competence protein
D2B33_00860	COG2747	anti-sigma28 factor FlgM
D2B33_00865	COG3418	PFAM FlgN family protein
D2B33_00870	COG1256	bacterial-type flagellum assembly
D2B33_00870	COG4786	Flagellar basal body rod
D2B33_00875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D2B33_00885	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D2B33_00890	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D2B33_00895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D2B33_00905	COG1334	flagellar protein FlaG
D2B33_00910	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D2B33_00915	COG1516	flagellar protein fliS
D2B33_00930	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D2B33_00935	COG0653	protein targeting
D2B33_00945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_00950	COG2010	Cytochrome c
D2B33_00960	COG2884	Cell division ATP-binding protein ftsE
D2B33_00965	COG2177	Part of the ABC transporter FtsEX involved in
D2B33_00970	COG3883	PFAM NLP P60 protein
D2B33_00970	COG0791	NLP P60 protein
D2B33_00975	COG0473	3-isopropylmalate dehydrogenase activity
D2B33_00980	COG0793	Belongs to the peptidase S41A family
D2B33_00980	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_00990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_01000	COG4897	Protein conserved in bacteria
D2B33_01005	COG0556	nucleotide-excision repair
D2B33_01010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D2B33_01030	COG3595	metallopeptidase activity
D2B33_01035	COG1983	PspC domain protein
D2B33_01040	COG1950	PFAM Membrane protein of
D2B33_01045	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D2B33_01050	COG2814	Major facilitator Superfamily
D2B33_01055	COG1846	Transcriptional regulator
D2B33_01060	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D2B33_01065	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D2B33_01070	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D2B33_01075	COG0546	phosphoglycolate phosphatase activity
D2B33_01080	COG0110	maltose O-acetyltransferase activity
D2B33_01085	COG5297	Belongs to the glycosyl hydrolase family 6
D2B33_01090	COG4990	cell redox homeostasis
D2B33_01095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D2B33_01100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D2B33_01105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D2B33_01110	COG0131	Imidazoleglycerol-phosphate dehydratase
D2B33_01115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D2B33_01120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D2B33_01125	COG0107	imidazoleglycerol-phosphate synthase activity
D2B33_01130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D2B33_01130	COG0140	phosphoribosyl-ATP diphosphatase activity
D2B33_01135	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_01140	COG0457	Tetratricopeptide repeat
D2B33_01145	COG0492	ferredoxin-NADP+ reductase activity
D2B33_01155	COG1051	belongs to the nudix hydrolase family
D2B33_01160	COG1660	Displays ATPase and GTPase activities
D2B33_01165	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D2B33_01170	COG1481	regulation of sporulation
D2B33_01175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_01180	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D2B33_01185	COG2732	(Barnase) inhibitor
D2B33_01195	COG0640	Transcriptional regulator
D2B33_01200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D2B33_01205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_01210	COG0288	reversible hydration of carbon dioxide
D2B33_01215	COG0659	secondary active sulfate transmembrane transporter activity
D2B33_01220	COG1078	dGTPase activity
D2B33_01225	COG1694	Mazg nucleotide pyrophosphohydrolase
D2B33_01230	COG1611	Belongs to the LOG family
D2B33_01235	COG0740	serine-type endopeptidase activity
D2B33_01250	COG1621	beta-fructofuranosidase activity
D2B33_01255	COG1621	beta-fructofuranosidase activity
D2B33_01260	COG1902	pentaerythritol trinitrate reductase activity
D2B33_01265	COG1733	regulation of RNA biosynthetic process
D2B33_01275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2B33_01280	COG1454	alcohol dehydrogenase
D2B33_01290	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D2B33_01300	COG2271	Major facilitator Superfamily
D2B33_01305	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_01310	COG1396	sequence-specific DNA binding
D2B33_01315	COG3944	biosynthesis protein
D2B33_01320	COG0489	protein tyrosine kinase activity
D2B33_01325	COG1086	Polysaccharide biosynthesis protein
D2B33_01330	COG0438	transferase activity, transferring glycosyl groups
D2B33_01335	COG1215	transferase activity, transferring glycosyl groups
D2B33_01340	COG0438	transferase activity, transferring glycosyl groups
D2B33_01350	COG1216	Glycosyl transferase, family 2
D2B33_01355	COG5039	Polysaccharide pyruvyl transferase
D2B33_01360	COG1216	Glycosyl transferase, family 2
D2B33_01380	COG0110	maltose O-acetyltransferase activity
D2B33_01385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2B33_01390	COG5039	Polysaccharide pyruvyl transferase
D2B33_01400	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D2B33_01405	COG1620	l-lactate permease
D2B33_01410	COG2186	Transcriptional regulator
D2B33_01415	COG0247	lactate metabolic process
D2B33_01420	COG1139	Iron-sulfur cluster binding protein
D2B33_01425	COG1556	Lactate utilization protein
D2B33_01450	COG1113	amino acid transport
D2B33_01455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_01460	COG2390	Transcriptional regulator
D2B33_01465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D2B33_01475	COG0126	phosphoglycerate kinase activity
D2B33_01480	COG0149	triose-phosphate isomerase activity
D2B33_01485	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D2B33_01490	COG0148	phosphopyruvate hydratase activity
D2B33_01495	COG0693	protein deglycase activity
D2B33_01515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_01520	COG4640	response to antibiotic
D2B33_01525	COG3064	Membrane
D2B33_01530	COG2095	MarC family integral membrane protein
D2B33_01535	COG1510	regulation of RNA biosynthetic process
D2B33_01540	COG0517	IMP dehydrogenase activity
D2B33_01540	COG1125	glycine betaine transport
D2B33_01545	COG1174	glycine betaine transport
D2B33_01550	COG1732	Glycine betaine
D2B33_01555	COG1174	glycine betaine transport
D2B33_01560	COG1396	sequence-specific DNA binding
D2B33_01565	COG1396	sequence-specific DNA binding
D2B33_01570	COG1476	TRANSCRIPTIONal
D2B33_01575	COG2002	toxin-antitoxin pair type II binding
D2B33_01580	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D2B33_01585	COG1647	Serine aminopeptidase, S33
D2B33_01590	COG0557	exoribonuclease II activity
D2B33_01595	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D2B33_01615	COG5444	nuclease activity
D2B33_01630	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_01635	COG5520	Belongs to the glycosyl hydrolase 30 family
D2B33_01655	COG2140	Oxalate decarboxylase
D2B33_01665	COG1191	sigma factor activity
D2B33_01680	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2B33_01685	COG0673	inositol 2-dehydrogenase activity
D2B33_01695	COG1846	Transcriptional regulator
D2B33_01705	COG2124	cytochrome p450
D2B33_01715	COG2814	Major facilitator Superfamily
D2B33_01720	COG2814	Major facilitator Superfamily
D2B33_01725	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_01725	COG3347	Dehydrogenase
D2B33_01735	COG4952	isomerase
D2B33_01740	COG1070	Carbohydrate kinase
D2B33_01745	COG1349	DNA-binding transcription factor activity
D2B33_01750	COG0693	protein deglycase activity
D2B33_01755	COG1937	Protein conserved in bacteria
D2B33_01760	COG2608	mercury ion transmembrane transporter activity
D2B33_01765	COG2217	Heavy metal translocating P-type atpase
D2B33_01775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_01780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_01780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_01780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_01800	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2B33_01805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2B33_01810	COG1121	(ABC) transporter
D2B33_01815	COG1472	Belongs to the glycosyl hydrolase 3 family
D2B33_01820	COG1501	Belongs to the glycosyl hydrolase 31 family
D2B33_01825	COG0395	ABC-type sugar transport system, permease component
D2B33_01830	COG1175	transmembrane transport
D2B33_01835	COG1653	transport
D2B33_01840	COG2217	Heavy metal translocating P-type atpase
D2B33_01845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D2B33_01850	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D2B33_01855	COG0456	acetyltransferase
D2B33_01860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D2B33_01860	COG0456	acetyltransferase
D2B33_01865	COG2860	membrane
D2B33_01870	COG3973	AAA domain
D2B33_01875	COG0596	Alpha beta hydrolase
D2B33_01885	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2B33_01890	COG1940	carbohydrate kinase activity
D2B33_01895	COG0656	L-ascorbic acid biosynthetic process
D2B33_01900	COG2814	Major facilitator Superfamily
D2B33_01905	COG1368	sulfuric ester hydrolase activity
D2B33_01910	COG1988	membrane-bound metal-dependent
D2B33_01920	COG0531	amino acid
D2B33_01925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_01930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_01935	COG1120	ATPase activity
D2B33_01940	COG0745	RESPONSE REGULATOR receiver
D2B33_01945	COG2205	protein histidine kinase activity
D2B33_01950	COG1904	glucuronate isomerase
D2B33_01955	COG2211	Major facilitator Superfamily
D2B33_01960	COG1609	Transcriptional regulator
D2B33_01965	COG0246	Mannitol dehydrogenase
D2B33_01970	COG2721	sulfolactate sulfo-lyase activity
D2B33_01980	COG0583	DNA-binding transcription factor activity
D2B33_01985	COG2258	MOSC domain
D2B33_01990	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_01995	COG1802	Transcriptional regulator
D2B33_02000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_02005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_02010	COG1120	ATPase activity
D2B33_02015	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2B33_02020	COG1454	alcohol dehydrogenase
D2B33_02040	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_02045	COG2096	Adenosyltransferase
D2B33_02050	COG4677	pectinesterase activity
D2B33_02055	COG4758	membrane
D2B33_02060	COG1842	Phage shock protein A
D2B33_02070	COG4758	membrane
D2B33_02075	COG4585	Histidine kinase
D2B33_02080	COG2197	response regulator
D2B33_02095	COG0814	amino acid
D2B33_02100	COG0697	spore germination
D2B33_02110	COG0114	fumarate hydratase activity
D2B33_02115	COG1309	transcriptional regulator
D2B33_02120	COG2205	protein histidine kinase activity
D2B33_02120	COG2770	Histidine kinase
D2B33_02125	COG0745	RESPONSE REGULATOR receiver
D2B33_02130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_02140	COG0783	Belongs to the Dps family
D2B33_02145	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_02150	COG1686	Belongs to the peptidase S11 family
D2B33_02165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_02170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_02175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_02180	COG1120	ATPase activity
D2B33_02195	COG5577	PFAM Coat F domain
D2B33_02210	COG1024	Enoyl-CoA hydratase
D2B33_02210	COG1250	3-hydroxyacyl-CoA dehydrogenase
D2B33_02215	COG0183	Belongs to the thiolase family
D2B33_02220	COG1960	acyl-CoA dehydrogenase activity
D2B33_02225	COG1393	Belongs to the ArsC family
D2B33_02230	COG0509	glycine decarboxylation via glycine cleavage system
D2B33_02240	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D2B33_02245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_02255	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D2B33_02260	COG2011	ABC-type metal ion transport system permease component
D2B33_02265	COG1464	Belongs to the NlpA lipoprotein family
D2B33_02270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D2B33_02280	COG0396	ATPase activity
D2B33_02285	COG0719	Fe-S assembly protein
D2B33_02290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D2B33_02295	COG0822	iron-sulfur transferase activity
D2B33_02300	COG0719	Fe-S assembly protein
D2B33_02310	COG0457	Tetratricopeptide repeat
D2B33_02325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2B33_02335	COG2356	endonuclease I
D2B33_02350	COG1288	antiporter activity
D2B33_02355	COG2814	Major facilitator Superfamily
D2B33_02360	COG2508	Transcriptional regulator
D2B33_02365	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D2B33_02370	COG3226	Transcriptional regulator
D2B33_02380	COG1801	Protein of unknown function DUF72
D2B33_02385	COG0730	response to heat
D2B33_02390	COG0737	Belongs to the 5'-nucleotidase family
D2B33_02395	COG3377	Domain of unknown function (DUF1805)
D2B33_02405	COG0733	neurotransmitter:sodium symporter activity
D2B33_02415	COG0739	heme binding
D2B33_02430	COG4470	Protein conserved in bacteria
D2B33_02435	COG2445	Protein of unknown function DUF86
D2B33_02440	COG0647	UMP catabolic process
D2B33_02445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D2B33_02450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2B33_02455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_02460	COG0460	homoserine dehydrogenase
D2B33_02465	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D2B33_02470	COG0083	homoserine kinase activity
D2B33_02475	COG4946	Tricorn protease homolog
D2B33_02475	COG1506	peptidase
D2B33_02475	COG0823	Involved in the tonB-independent uptake of proteins
D2B33_02480	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D2B33_02485	COG4837	Protein of unknown function (DUF1462)
D2B33_02495	COG3479	Phenolic acid decarboxylase
D2B33_02500	COG0457	Tetratricopeptide repeat
D2B33_02515	COG5646	InterPro IPR014922
D2B33_02520	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D2B33_02525	COG2323	membrane
D2B33_02530	COG1252	NADH dehydrogenase
D2B33_02535	COG4844	belongs to the
D2B33_02540	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2B33_02545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D2B33_02550	COG0316	Belongs to the HesB IscA family
D2B33_02555	COG0454	-acetyltransferase
D2B33_02570	COG0492	ferredoxin-NADP+ reductase activity
D2B33_02575	COG1252	NADH dehydrogenase
D2B33_02585	COG3584	3D domain protein
D2B33_02590	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D2B33_02595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D2B33_02600	COG2056	Na+-H+ antiporter family
D2B33_02605	COG1268	BioY protein
D2B33_02610	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D2B33_02620	COG0686	Belongs to the AlaDH PNT family
D2B33_02625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D2B33_02625	COG2508	Transcriptional regulator
D2B33_02630	COG1115	amino acid carrier protein
D2B33_02635	COG4842	Belongs to the WXG100 family
D2B33_02640	COG5417	Belongs to the EsaB family
D2B33_02645	COG4499	WXG100 protein secretion system (Wss), protein YukC
D2B33_02650	COG1674	ftsk spoiiie
D2B33_02650	COG0433	COG0433 Predicted ATPase
D2B33_02655	COG1511	domain protein
D2B33_02670	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_02675	COG1418	mRNA catabolic process
D2B33_02690	COG1959	2 iron, 2 sulfur cluster binding
D2B33_02695	COG0628	permease
D2B33_02710	COG5506	Protein of unknown function (DUF1694)
D2B33_02715	COG1335	isochorismatase
D2B33_02720	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D2B33_02725	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D2B33_02760	COG3226	Transcriptional regulator
D2B33_02780	COG4585	Histidine kinase
D2B33_02785	COG2197	response regulator
D2B33_02790	COG2050	protein possibly involved in aromatic compounds catabolism
D2B33_02795	COG1320	monovalent cation:proton antiporter activity
D2B33_02800	COG2212	antiporter activity
D2B33_02805	COG1863	multisubunit Na H antiporter MnhE subunit
D2B33_02810	COG0651	ATP synthesis coupled electron transport
D2B33_02815	COG1006	Multisubunit Na H antiporter MnhC subunit
D2B33_02820	COG2111	Na H antiporter
D2B33_02825	COG2111	Na H antiporter
D2B33_02825	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D2B33_02835	COG3493	citrate carrier protein
D2B33_02840	COG0688	phosphatidylethanolamine metabolic process
D2B33_02845	COG0586	Pfam SNARE associated Golgi protein
D2B33_02850	COG1183	phosphatidylcholine synthase activity
D2B33_02860	COG4565	transcriptional regulatory protein
D2B33_02865	COG3290	protein histidine kinase activity
D2B33_02875	COG3011	Protein conserved in bacteria
D2B33_02880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_02885	COG2814	Major facilitator Superfamily
D2B33_02890	COG5018	Exonuclease
D2B33_02905	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D2B33_02920	COG2267	carboxylic ester hydrolase activity
D2B33_02925	COG1522	sequence-specific DNA binding
D2B33_02930	COG0436	Aminotransferase
D2B33_02935	COG1098	S1 RNA binding domain
D2B33_02940	COG2155	Conserved Protein
D2B33_02945	COG1979	alcohol dehydrogenase
D2B33_02950	COG0166	Belongs to the GPI family
D2B33_02960	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D2B33_02965	COG2323	membrane
D2B33_02975	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D2B33_02990	COG2738	Putative neutral zinc metallopeptidase
D2B33_02995	COG1253	flavin adenine dinucleotide binding
D2B33_03000	COG5297	Belongs to the glycosyl hydrolase family 6
D2B33_03015	COG0366	Alpha amylase catalytic
D2B33_03020	COG0432	Pfam Uncharacterised protein family UPF0047
D2B33_03025	COG2070	2-Nitropropane dioxygenase
D2B33_03035	COG0840	transmembrane signaling receptor activity
D2B33_03040	COG0840	transmembrane signaling receptor activity
D2B33_03045	COG0840	transmembrane signaling receptor activity
D2B33_03050	COG0693	protein deglycase activity
D2B33_03055	COG0673	inositol 2-dehydrogenase activity
D2B33_03060	COG0628	permease
D2B33_03065	COG1968	undecaprenyl-diphosphatase activity
D2B33_03070	COG1408	metallophosphoesterase
D2B33_03075	COG0726	polysaccharide deacetylase
D2B33_03080	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_03090	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D2B33_03180	COG1397	ADP-ribosylglycohydrolase
D2B33_03190	COG4974	Belongs to the 'phage' integrase family
D2B33_03320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_03320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_03355	COG1780	Probably involved in ribonucleotide reductase function
D2B33_03360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2B33_03395	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
D2B33_03400	COG3584	3D domain protein
D2B33_03455	COG1793	dna ligase
D2B33_03595	COG1388	LysM domain
D2B33_03595	COG5632	N-Acetylmuramoyl-L-alanine amidase
D2B33_03595	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_03630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2B33_03635	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D2B33_03645	COG1510	regulation of RNA biosynthetic process
D2B33_03660	COG1454	alcohol dehydrogenase
D2B33_03670	COG2318	DinB family
D2B33_03685	COG0569	domain protein
D2B33_03690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D2B33_03695	COG0457	Tetratricopeptide repeat
D2B33_03710	COG3764	Sortase (surface protein transpeptidase)
D2B33_03715	COG3859	Proton-coupled thiamine transporter YuaJ
D2B33_03720	COG1609	Transcriptional regulator
D2B33_03845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D2B33_03850	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D2B33_03855	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D2B33_03860	COG0297	glycogen (starch) synthase activity
D2B33_03865	COG0058	SHG alpha-glucan phosphorylase activity
D2B33_03870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2B33_03875	COG1575	Belongs to the MenA family. Type 1 subfamily
D2B33_03880	COG1169	isochorismate synthase
D2B33_03885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D2B33_03890	COG0596	Alpha beta hydrolase
D2B33_03895	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D2B33_03900	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_03905	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_03920	COG1294	oxidase, subunit
D2B33_03925	COG1271	oxidase subunit
D2B33_03930	COG0254	rRNA binding
D2B33_03935	COG0803	Belongs to the bacterial solute-binding protein 9 family
D2B33_03940	COG0523	cobalamin synthesis protein
D2B33_03945	COG0288	reversible hydration of carbon dioxide
D2B33_03950	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D2B33_03955	COG1854	S-ribosylhomocysteine lyase activity
D2B33_03970	COG0783	Belongs to the Dps family
D2B33_03975	COG4824	toxin secretion phage lysis holin
D2B33_03985	COG0494	nUDIX hydrolase
D2B33_03990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D2B33_03995	COG1116	anion transmembrane transporter activity
D2B33_04000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2B33_04005	COG1506	peptidase
D2B33_04020	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D2B33_04025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D2B33_04030	COG0367	asparagine synthase
D2B33_04035	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_04035	COG0438	transferase activity, transferring glycosyl groups
D2B33_04040	COG0671	phosphoesterase, PA-phosphatase related
D2B33_04045	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D2B33_04050	COG2267	carboxylic ester hydrolase activity
D2B33_04060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D2B33_04065	COG1242	4 iron, 4 sulfur cluster binding
D2B33_04075	COG1725	Transcriptional regulator
D2B33_04080	COG1131	(ABC) transporter
D2B33_04090	COG1136	(ABC) transporter
D2B33_04095	COG0577	efflux transmembrane transporter activity
D2B33_04105	COG1464	Belongs to the NlpA lipoprotein family
D2B33_04110	COG2814	Major facilitator Superfamily
D2B33_04120	COG0495	leucyl-tRNA aminoacylation
D2B33_04125	COG0346	lactoylglutathione lyase activity
D2B33_04130	COG0583	DNA-binding transcription factor activity
D2B33_04140	COG1073	alpha beta
D2B33_04145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2B33_04150	COG0395	ABC-type sugar transport system, permease component
D2B33_04155	COG1653	transport
D2B33_04160	COG2207	Transcriptional regulator
D2B33_04165	COG4209	transmembrane transport
D2B33_04170	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D2B33_04175	COG1653	transport
D2B33_04180	COG0673	inositol 2-dehydrogenase activity
D2B33_04185	COG5578	integral membrane protein
D2B33_04200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_04210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D2B33_04215	COG2081	HI0933 family
D2B33_04220	COG2244	polysaccharide biosynthetic process
D2B33_04225	COG1187	pseudouridine synthase activity
D2B33_04230	COG1349	DNA-binding transcription factor activity
D2B33_04235	COG1131	(ABC) transporter
D2B33_04240	COG4473	ABC transporter
D2B33_04245	COG2252	PERMEase
D2B33_04250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2B33_04265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2B33_04270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D2B33_04280	COG1597	lipid kinase activity
D2B33_04285	COG1523	belongs to the glycosyl hydrolase 13 family
D2B33_04290	COG0510	thiamine kinase activity
D2B33_04300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D2B33_04305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_04310	COG0281	malic enzyme
D2B33_04315	COG5584	Small secreted protein
D2B33_04320	COG1363	Peptidase, m42
D2B33_04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_04335	COG4848	Belongs to the UPF0354 family
D2B33_04340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_04345	COG1674	ftsk spoiiie
D2B33_04350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D2B33_04355	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D2B33_04360	COG4980	gas vesicle protein
D2B33_04365	COG3118	belongs to the thioredoxin family
D2B33_04375	COG1605	Chorismate mutase
D2B33_04375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D2B33_04380	COG1609	Transcriptional regulator
D2B33_04385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D2B33_04390	COG1360	Flagellar Motor Protein
D2B33_04395	COG0123	including yeast histone deacetylase and acetoin utilization protein
D2B33_04400	COG0517	IMP dehydrogenase activity
D2B33_04405	COG0454	-acetyltransferase
D2B33_04410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2B33_04415	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D2B33_04430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D2B33_04435	COG2203	Gaf domain
D2B33_04435	COG2199	diguanylate cyclase activity
D2B33_04440	COG1956	GAF domain-containing protein
D2B33_04445	COG1309	transcriptional regulator
D2B33_04450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D2B33_04455	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D2B33_04460	COG1114	Component of the transport system for branched-chain amino acids
D2B33_04465	COG1104	cysteine desulfurase activity
D2B33_04470	COG0301	tRNA thio-modification
D2B33_04480	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2B33_04485	COG1846	Transcriptional regulator
D2B33_04490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2B33_04495	COG0616	signal peptide processing
D2B33_04500	COG1714	RDD family
D2B33_04510	COG3874	Sporulation protein YtfJ
D2B33_04515	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D2B33_04520	COG0827	DNA restriction-modification system
D2B33_04525	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D2B33_04530	COG0521	Mo-molybdopterin cofactor biosynthetic process
D2B33_04535	COG0137	argininosuccinate synthase activity
D2B33_04540	COG0165	Argininosuccinate lyase
D2B33_04545	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_04550	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D2B33_04555	COG1695	Transcriptional regulator
D2B33_04560	COG4109	DRTGG domain
D2B33_04570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D2B33_04590	COG0587	DNA-directed DNA polymerase activity
D2B33_04595	COG0281	malic enzyme
D2B33_04600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D2B33_04605	COG0825	malonyl-CoA metabolic process
D2B33_04610	COG0205	6-phosphofructokinase activity
D2B33_04620	COG3030	protein affecting phage T7 exclusion by the F plasmid
D2B33_04625	COG0628	permease
D2B33_04630	COG2707	UPF0756 membrane protein
D2B33_04640	COG2273	Hydrolase Family 16
D2B33_04650	COG0372	Belongs to the citrate synthase family
D2B33_04655	COG0538	isocitrate dehydrogenase activity
D2B33_04660	COG0039	L-malate dehydrogenase activity
D2B33_04665	COG0745	RESPONSE REGULATOR receiver
D2B33_04670	COG5002	protein histidine kinase activity
D2B33_04675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_04675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_04680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D2B33_04685	COG1971	Probably functions as a manganese efflux pump
D2B33_04690	COG0237	dephospho-CoA kinase activity
D2B33_04695	COG3866	Pectate lyase
D2B33_04700	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D2B33_04705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D2B33_04720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D2B33_04725	COG3611	Membrane attachment protein
D2B33_04730	COG1484	DNA-dependent DNA replication
D2B33_04735	COG0398	Pfam SNARE associated Golgi protein
D2B33_04745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D2B33_04760	COG3275	phosphorelay sensor kinase activity
D2B33_04765	COG3279	Response regulator of the LytR AlgR family
D2B33_04770	COG3540	Alkaline phosphatase
D2B33_04780	COG1346	cytolysis
D2B33_04785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D2B33_04790	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D2B33_04795	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D2B33_04800	COG3326	Membrane
D2B33_04810	COG1363	Peptidase, m42
D2B33_04815	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_04820	COG2160	L-arabinose isomerase activity
D2B33_04825	COG1069	ribulokinase activity
D2B33_04830	COG0235	Class ii aldolase
D2B33_04835	COG0371	Dehydrogenase
D2B33_04840	COG1653	transport
D2B33_04845	COG1175	transmembrane transport
D2B33_04850	COG0395	ABC-type sugar transport system, permease component
D2B33_04870	COG3402	PFAM membrane-flanked domain
D2B33_04875	COG1309	transcriptional regulator
D2B33_04880	COG1966	Carbon starvation protein
D2B33_04890	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2B33_04895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D2B33_04900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_04900	COG0072	phenylalanine-tRNA ligase activity
D2B33_04920	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D2B33_04925	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D2B33_04930	COG1286	toxin biosynthetic process
D2B33_04935	COG1796	DNA polymerase
D2B33_04935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D2B33_04940	COG1193	negative regulation of DNA recombination
D2B33_04945	COG3766	membrane
D2B33_04950	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_04955	COG1309	transcriptional regulator
D2B33_04960	COG1024	Enoyl-CoA hydratase
D2B33_04965	COG2086	electron transfer activity
D2B33_04970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D2B33_04980	COG3118	belongs to the thioredoxin family
D2B33_04985	COG0322	excinuclease ABC activity
D2B33_04995	COG0527	aspartate kinase activity
D2B33_05000	COG1719	4-vinyl reductase, 4VR
D2B33_05005	COG2009	succinate dehydrogenase
D2B33_05010	COG1053	succinate dehydrogenase
D2B33_05015	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D2B33_05020	COG0824	Thioesterase
D2B33_05025	COG4221	oxidoreductase activity
D2B33_05030	COG2197	response regulator
D2B33_05035	COG1846	Transcriptional regulator
D2B33_05040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D2B33_05045	COG5401	PFAM Sporulation and spore germination
D2B33_05050	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D2B33_05055	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D2B33_05060	COG0622	Phosphoesterase
D2B33_05080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2B33_05090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2B33_05095	COG0028	Belongs to the TPP enzyme family
D2B33_05100	COG0440	acetolactate synthase activity
D2B33_05105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D2B33_05110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D2B33_05115	COG0473	3-isopropylmalate dehydrogenase activity
D2B33_05120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D2B33_05125	COG0066	3-isopropylmalate dehydratase activity
D2B33_05130	COG1477	protein flavinylation
D2B33_05130	COG0457	Tetratricopeptide repeat
D2B33_05135	COG0544	peptidyl-prolyl cis-trans isomerase activity
D2B33_05140	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D2B33_05145	COG0470	DNA polymerase III
D2B33_05145	COG1067	ATP-dependent peptidase activity
D2B33_05150	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D2B33_05155	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D2B33_05165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D2B33_05170	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D2B33_05175	COG0181	hydroxymethylbilane synthase activity
D2B33_05180	COG1587	Uroporphyrinogen-III synthase
D2B33_05185	COG0113	porphobilinogen synthase activity
D2B33_05190	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D2B33_05195	COG1388	LysM domain
D2B33_05200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D2B33_05210	COG0525	valine-tRNA ligase activity
D2B33_05215	COG0285	dihydrofolate synthase activity
D2B33_05220	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D2B33_05230	COG0424	maF-like protein
D2B33_05235	COG2003	Belongs to the UPF0758 family
D2B33_05250	COG1396	sequence-specific DNA binding
D2B33_05365	COG4626	Terminase
D2B33_05365	COG1802	Transcriptional regulator
D2B33_05440	COG1705	Flagellar rod assembly protein muramidase FlgJ
D2B33_05440	COG1388	LysM domain
D2B33_05445	COG5434	Belongs to the glycosyl hydrolase 28 family
D2B33_05515	COG1077	Cell shape determining protein MreB Mrl
D2B33_05520	COG1792	Involved in formation and maintenance of cell shape
D2B33_05525	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D2B33_05530	COG0850	regulation of cytokinetic process
D2B33_05535	COG2894	cell division
D2B33_05540	COG0640	Transcriptional regulator
D2B33_05545	COG3832	glyoxalase III activity
D2B33_05550	COG0739	heme binding
D2B33_05555	COG1994	Peptidase M50
D2B33_05560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D2B33_05565	COG2868	ribosomal protein
D2B33_05570	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D2B33_05575	COG3290	protein histidine kinase activity
D2B33_05580	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D2B33_05585	COG4492	Belongs to the UPF0735 family
D2B33_05590	COG0077	Prephenate dehydratase
D2B33_05595	COG1827	regulation of RNA biosynthetic process
D2B33_05600	COG1104	cysteine desulfurase activity
D2B33_05605	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D2B33_05610	COG0157	Belongs to the NadC ModD family
D2B33_05615	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D2B33_05620	COG1388	LysM domain
D2B33_05630	COG0217	transcriptional regulatory protein
D2B33_05645	COG4195	phage-related replication protein
D2B33_05650	COG2318	DinB family
D2B33_05660	COG2112	serine threonine protein kinase
D2B33_05670	COG0632	four-way junction helicase activity
D2B33_05675	COG2255	four-way junction helicase activity
D2B33_05685	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D2B33_05690	COG0343	queuine tRNA-ribosyltransferase activity
D2B33_05695	COG1862	Preprotein translocase
D2B33_05705	COG2323	membrane
D2B33_05710	COG2244	polysaccharide biosynthetic process
D2B33_05720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D2B33_05720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D2B33_05725	COG5416	Lipopolysaccharide assembly protein A domain
D2B33_05730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D2B33_05730	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D2B33_05735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2B33_05740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D2B33_05745	COG1490	D-aminoacyl-tRNA deacylase activity
D2B33_05750	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_05750	COG4991	sh3 domain protein
D2B33_05750	COG3103	Sh3 type 3 domain protein
D2B33_05755	COG0124	histidyl-tRNA synthetase
D2B33_05760	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D2B33_05770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D2B33_05775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D2B33_05780	COG1959	2 iron, 2 sulfur cluster binding
D2B33_05785	COG1104	cysteine desulfurase activity
D2B33_05790	COG0482	sulfurtransferase activity
D2B33_05795	COG0457	Tetratricopeptide repeat
D2B33_05800	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D2B33_05805	COG3881	PFAM PRC-barrel domain
D2B33_05820	COG0628	permease
D2B33_05825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D2B33_05830	COG4472	Bacterial protein of unknown function (DUF965)
D2B33_05835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D2B33_05840	COG3906	Belongs to the UPF0473 family
D2B33_05845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2B33_05865	COG0572	uridine kinase
D2B33_05870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D2B33_05875	COG0768	penicillin binding
D2B33_05890	COG2226	methyltransferase
D2B33_05895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D2B33_05900	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2B33_05905	COG0626	cystathionine gamma-synthase activity
D2B33_05925	COG2226	methyltransferase
D2B33_05930	COG1404	Belongs to the peptidase S8 family
D2B33_05935	COG1309	transcriptional regulator
D2B33_05940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2B33_05940	COG2124	cytochrome p450
D2B33_05950	COG2814	Major facilitator Superfamily
D2B33_05955	COG0583	DNA-binding transcription factor activity
D2B33_05960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_05970	COG1587	Uroporphyrinogen-III synthase
D2B33_05975	COG3340	Belongs to the peptidase S51 family
D2B33_05980	COG1733	regulation of RNA biosynthetic process
D2B33_05985	COG2814	Major facilitator Superfamily
D2B33_05990	COG0656	L-ascorbic acid biosynthetic process
D2B33_06015	COG2205	protein histidine kinase activity
D2B33_06020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2B33_06025	COG2169	Transcriptional regulator
D2B33_06045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D2B33_06045	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D2B33_06050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_06055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_06060	COG3715	PTS system
D2B33_06065	COG3716	PTS system mannose fructose sorbose family IID component
D2B33_06070	COG1621	beta-fructofuranosidase activity
D2B33_06075	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_06085	COG2211	Major facilitator Superfamily
D2B33_06090	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_06095	COG0730	response to heat
D2B33_06100	COG2124	cytochrome p450
D2B33_06115	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_06135	COG4608	Belongs to the ABC transporter superfamily
D2B33_06140	COG0444	Belongs to the ABC transporter superfamily
D2B33_06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_06150	COG0601	transmembrane transport
D2B33_06155	COG0747	negative chemotaxis
D2B33_06160	COG0492	ferredoxin-NADP+ reductase activity
D2B33_06165	COG2197	response regulator
D2B33_06170	COG4585	Histidine kinase
D2B33_06175	COG3239	Fatty acid desaturase
D2B33_06180	COG1733	regulation of RNA biosynthetic process
D2B33_06185	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D2B33_06190	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D2B33_06195	COG1942	4-Oxalocrotonate Tautomerase
D2B33_06230	COG1937	Protein conserved in bacteria
D2B33_06235	COG2210	Belongs to the sulfur carrier protein TusA family
D2B33_06240	COG0425	Belongs to the sulfur carrier protein TusA family
D2B33_06240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_06245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_06245	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_06250	COG0425	Belongs to the sulfur carrier protein TusA family
D2B33_06255	COG0730	response to heat
D2B33_06260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_06265	COG4585	Histidine kinase
D2B33_06270	COG2197	response regulator
D2B33_06305	COG3226	Transcriptional regulator
D2B33_06315	COG2223	nitrite transmembrane transporter activity
D2B33_06320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D2B33_06325	COG1140	nitrate reductase beta subunit
D2B33_06330	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D2B33_06335	COG2181	nitrate reductase activity
D2B33_06345	COG2828	Protein conserved in bacteria
D2B33_06350	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D2B33_06365	COG0789	Transcriptional regulator
D2B33_06365	COG4978	Transcriptional regulator
D2B33_06380	COG1486	melibiose metabolic process
D2B33_06385	COG0561	phosphatase activity
D2B33_06400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_06405	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_06410	COG2723	6-phospho-beta-galactosidase activity
D2B33_06450	COG2427	Protein of unknown function (DUF1641)
D2B33_06455	COG3383	formate dehydrogenase (NAD+) activity
D2B33_06460	COG5609	conserved protein (DUF2294)
D2B33_06470	COG2755	lipolytic protein G-D-S-L family
D2B33_06480	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D2B33_06485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2B33_06490	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D2B33_06495	COG1534	Rna-binding protein
D2B33_06500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D2B33_06505	COG1713	HD superfamily hydrolase involved in NAD metabolism
D2B33_06510	COG0799	negative regulation of ribosome biogenesis
D2B33_06515	COG2226	methyltransferase
D2B33_06520	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2B33_06525	COG1596	polysaccharide export
D2B33_06525	COG1555	photosystem II stabilization
D2B33_06530	COG2131	deaminase
D2B33_06535	COG2333	competence protein COMEC
D2B33_06535	COG0658	competence protein
D2B33_06545	COG1466	dna polymerase III delta subunit
D2B33_06550	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_06555	COG1733	regulation of RNA biosynthetic process
D2B33_06565	COG0268	Binds directly to 16S ribosomal RNA
D2B33_06570	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D2B33_06575	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_06585	COG0481	GTPase activity
D2B33_06590	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2B33_06595	COG1420	regulation of RNA biosynthetic process
D2B33_06600	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D2B33_06605	COG0443	Heat shock 70 kDa protein
D2B33_06610	COG0484	heat shock protein binding
D2B33_06615	COG2264	protein methyltransferase activity
D2B33_06620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D2B33_06625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D2B33_06630	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D2B33_06635	COG1283	sodium-dependent phosphate transmembrane transporter activity
D2B33_06640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D2B33_06645	COG1610	YqeY-like protein
D2B33_06650	COG1030	water channel activity
D2B33_06655	COG4864	UPF0365 protein
D2B33_06670	COG0561	phosphatase activity
D2B33_06675	COG1702	phosphate starvation-inducible protein PhoH
D2B33_06680	COG1480	7TM receptor with intracellular HD hydrolase
D2B33_06685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D2B33_06690	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D2B33_06695	COG0295	cytidine deaminase activity
D2B33_06700	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D2B33_06710	COG1381	Involved in DNA repair and RecF pathway recombination
D2B33_06715	COG0752	glycyl-tRNA synthetase alpha subunit
D2B33_06720	COG0751	glycine-tRNA ligase activity
D2B33_06725	COG0517	IMP dehydrogenase activity
D2B33_06730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D2B33_06735	COG1671	Belongs to the UPF0178 family
D2B33_06740	COG0358	DNA primase activity
D2B33_06745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D2B33_06750	COG2010	Cytochrome c
D2B33_06765	COG5444	nuclease activity
D2B33_06790	COG2384	SAM-dependent methyltransferase
D2B33_06795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D2B33_06800	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D2B33_06810	COG0513	Belongs to the DEAD box helicase family
D2B33_06815	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D2B33_06825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_06830	COG1121	(ABC) transporter
D2B33_06835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D2B33_06840	COG0735	belongs to the Fur family
D2B33_06845	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D2B33_06850	COG4709	membrane
D2B33_06855	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D2B33_06860	COG1388	LysM domain
D2B33_06865	COG5521	maltodextrose utilization protein MalA
D2B33_06870	COG2839	Protein conserved in bacteria
D2B33_06875	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2B33_06880	COG0477	Major facilitator Superfamily
D2B33_06890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D2B33_06895	COG0573	inorganic phosphate transmembrane transporter activity
D2B33_06900	COG0581	inorganic phosphate transmembrane transporter activity
D2B33_06905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2B33_06910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D2B33_06960	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D2B33_06980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2B33_06985	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D2B33_06990	COG0705	Rhomboid family
D2B33_06990	COG0457	Tetratricopeptide repeat
D2B33_06995	COG0697	spore germination
D2B33_07000	COG4483	Protein conserved in bacteria
D2B33_07005	COG1940	carbohydrate kinase activity
D2B33_07010	COG1368	sulfuric ester hydrolase activity
D2B33_07015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_07020	COG2866	Carboxypeptidase
D2B33_07030	COG0011	TIGRFAM Protein of
D2B33_07040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_07050	COG1393	Belongs to the ArsC family
D2B33_07060	COG1366	Belongs to the anti-sigma-factor antagonist family
D2B33_07065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D2B33_07070	COG1459	type II secretion system
D2B33_07075	COG4537	Required for transformation and DNA binding
D2B33_07080	COG4970	Tfp pilus assembly protein FimT
D2B33_07090	COG4940	Competence protein ComGF
D2B33_07115	COG0681	Belongs to the peptidase S26 family
D2B33_07140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D2B33_07145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D2B33_07150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D2B33_07155	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D2B33_07160	COG0517	IMP dehydrogenase activity
D2B33_07160	COG4175	Glycine betaine
D2B33_07165	COG4176	ABC-type proline glycine betaine transport system permease component
D2B33_07170	COG2113	Glycine betaine
D2B33_07175	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_07180	COG0095	Lipoate-protein ligase
D2B33_07185	COG1321	iron dependent repressor
D2B33_07190	COG1752	Esterase of the alpha-beta hydrolase superfamily
D2B33_07200	COG3872	metal-dependent enzyme
D2B33_07210	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D2B33_07215	COG0006	proline dipeptidase activity
D2B33_07220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D2B33_07230	COG3854	ATPases associated with a variety of cellular activities
D2B33_07270	COG0511	ligase activity, forming carbon-carbon bonds
D2B33_07275	COG0439	Biotin carboxylase
D2B33_07280	COG1302	Protein conserved in bacteria
D2B33_07285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2B33_07290	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D2B33_07295	COG1570	exodeoxyribonuclease VII activity
D2B33_07300	COG1722	exodeoxyribonuclease VII activity
D2B33_07305	COG0142	geranyltranstransferase activity
D2B33_07310	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D2B33_07315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D2B33_07320	COG1438	arginine binding
D2B33_07325	COG0497	DNA recombination
D2B33_07330	COG0750	zinc metalloprotease
D2B33_07335	COG0745	RESPONSE REGULATOR receiver
D2B33_07360	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_07365	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_07375	COG3829	transcription factor binding
D2B33_07375	COG3290	protein histidine kinase activity
D2B33_07380	COG0280	phosphate acetyltransferase
D2B33_07390	COG3426	butyrate kinase activity
D2B33_07395	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2B33_07400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2B33_07405	COG0022	dehydrogenase e1 component
D2B33_07410	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_07415	COG1597	lipid kinase activity
D2B33_07435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2B33_07440	COG0765	amino acid transport
D2B33_07445	COG1126	abc transporter atp-binding protein
D2B33_07450	COG4129	membrane
D2B33_07455	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D2B33_07460	COG2195	Cleaves the N-terminal amino acid of tripeptides
D2B33_07465	COG0706	membrane insertase activity
D2B33_07475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D2B33_07480	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D2B33_07485	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_07490	COG1785	Belongs to the alkaline phosphatase family
D2B33_07495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_07500	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_07505	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_07510	COG2723	6-phospho-beta-galactosidase activity
D2B33_07515	COG2188	Transcriptional regulator
D2B33_07535	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D2B33_07540	COG1234	tRNA 3'-trailer cleavage
D2B33_07545	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D2B33_07550	COG0596	Alpha beta hydrolase
D2B33_07555	COG1902	pentaerythritol trinitrate reductase activity
D2B33_07560	COG4187	Peptidase family M20/M25/M40
D2B33_07565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2B33_07570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_07575	COG0300	oxidoreductase activity
D2B33_07585	COG4195	phage-related replication protein
D2B33_07595	COG2814	Major facilitator Superfamily
D2B33_07620	COG0745	RESPONSE REGULATOR receiver
D2B33_07625	COG2205	protein histidine kinase activity
D2B33_07670	COG1072	(Pantothenic acid kinase))
D2B33_07675	COG0346	lactoylglutathione lyase activity
D2B33_07680	COG2211	Major facilitator Superfamily
D2B33_07690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D2B33_07705	COG0534	Mate efflux family protein
D2B33_07715	COG0444	Belongs to the ABC transporter superfamily
D2B33_07720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_07725	COG0601	transmembrane transport
D2B33_07730	COG0747	negative chemotaxis
D2B33_07740	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D2B33_07745	COG2329	Antibiotic biosynthesis monooxygenase
D2B33_07750	COG0456	acetyltransferase
D2B33_07750	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D2B33_07760	COG4918	Iron-sulphur cluster biosynthesis
D2B33_07770	COG1073	alpha beta
D2B33_07780	COG0667	Aldo Keto reductase
D2B33_07790	COG1309	transcriptional regulator
D2B33_07800	COG0494	nUDIX hydrolase
D2B33_07805	COG1379	DNA repair
D2B33_07810	COG2153	protein acetylation
D2B33_07820	COG1953	Uracil, thiamine, allantoin
D2B33_07830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_07835	COG1300	Membrane
D2B33_07840	COG0735	belongs to the Fur family
D2B33_07850	COG4974	Belongs to the 'phage' integrase family
D2B33_07855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D2B33_07860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D2B33_07865	COG1686	Belongs to the peptidase S11 family
D2B33_07900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2B33_07915	COG0697	spore germination
D2B33_07925	COG0019	diaminopimelate decarboxylase activity
D2B33_07935	COG4195	phage-related replication protein
D2B33_07940	COG4086	secreted protein
D2B33_07945	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D2B33_07950	COG0457	Tetratricopeptide repeat
D2B33_07970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D2B33_07970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D2B33_07975	COG0307	riboflavin synthase, alpha
D2B33_07980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D2B33_07980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D2B33_07985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D2B33_07990	COG0456	acetyltransferase
D2B33_08000	COG1547	Domain of unknown function (DUF309)
D2B33_08010	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D2B33_08015	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D2B33_08025	COG1686	Belongs to the peptidase S11 family
D2B33_08030	COG2715	membrane protein required for spore maturation
D2B33_08035	COG0700	Nucleoside recognition
D2B33_08040	COG1187	pseudouridine synthase activity
D2B33_08045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_08050	COG1333	cytochrome c biogenesis protein
D2B33_08055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D2B33_08060	COG0745	RESPONSE REGULATOR receiver
D2B33_08065	COG5002	protein histidine kinase activity
D2B33_08070	COG0745	RESPONSE REGULATOR receiver
D2B33_08075	COG5002	protein histidine kinase activity
D2B33_08095	COG1595	DNA-templated transcription, initiation
D2B33_08105	COG0739	heme binding
D2B33_08110	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D2B33_08115	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D2B33_08120	COG1141	Ferredoxin
D2B33_08125	COG4955	Helix-turn-helix domain
D2B33_08130	COG0514	ATP-dependent DNA helicase (RecQ)
D2B33_08135	COG1266	CAAX protease self-immunity
D2B33_08140	COG1388	LysM domain
D2B33_08155	COG1408	metallophosphoesterase
D2B33_08160	COG4862	establishment of competence for transformation
D2B33_08165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D2B33_08170	COG0492	ferredoxin-NADP+ reductase activity
D2B33_08180	COG2339	peptidase activity
D2B33_08185	COG3773	Cell wall hydrolase
D2B33_08185	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_08190	COG2959	enzyme of heme biosynthesis
D2B33_08195	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D2B33_08200	COG0539	negative regulation of cytoplasmic translation
D2B33_08205	COG1304	FMN binding
D2B33_08230	COG1160	GTP binding
D2B33_08235	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D2B33_08255	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D2B33_08260	COG0776	regulation of translation
D2B33_08275	COG0142	geranyltranstransferase activity
D2B33_08280	COG2226	methyltransferase
D2B33_08285	COG0142	geranyltranstransferase activity
D2B33_08290	COG0105	UTP biosynthetic process
D2B33_08295	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D2B33_08300	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D2B33_08305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D2B33_08310	COG4401	Chorismate mutase type I
D2B33_08315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2B33_08320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D2B33_08325	COG0134	indole-3-glycerol-phosphate synthase activity
D2B33_08330	COG0135	phosphoribosylanthranilate isomerase activity
D2B33_08335	COG0133	tryptophan synthase activity
D2B33_08340	COG0159	tryptophan synthase activity
D2B33_08345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D2B33_08350	COG0287	Prephenate dehydrogenase
D2B33_08355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D2B33_08360	COG0457	Tetratricopeptide repeat
D2B33_08365	COG5582	Belongs to the UPF0302 family
D2B33_08375	COG0723	plastoquinol--plastocyanin reductase activity
D2B33_08380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D2B33_08385	COG2010	Cytochrome c
D2B33_08385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D2B33_08390	COG4347	Protein of unknown function (DUF1405)
D2B33_08400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_08405	COG1694	Mazg nucleotide pyrophosphohydrolase
D2B33_08410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D2B33_08415	COG1803	Methylglyoxal synthase
D2B33_08420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2B33_08425	COG0438	transferase activity, transferring glycosyl groups
D2B33_08430	COG0617	tRNA 3'-terminal CCA addition
D2B33_08445	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D2B33_08450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D2B33_08455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D2B33_08460	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D2B33_08460	COG1199	ATP-dependent helicase activity
D2B33_08470	COG5353	protein conserved in bacteria
D2B33_08475	COG0436	Aminotransferase
D2B33_08480	COG0017	Asparaginyl-tRNA synthetase
D2B33_08485	COG3935	DnaD domain protein
D2B33_08490	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D2B33_08500	COG4499	WXG100 protein secretion system (Wss), protein YukC
D2B33_08500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_08505	COG3331	DNA recombination
D2B33_08540	COG0071	Belongs to the small heat shock protein (HSP20) family
D2B33_08545	COG2190	(PTS) system
D2B33_08550	COG1111	helicase
D2B33_08550	COG1205	dead DEAH box helicase
D2B33_08555	COG3359	exonuclease
D2B33_08565	COG4474	Belongs to the UPF0398 family
D2B33_08570	COG3599	regulation of cell shape
D2B33_08580	COG0116	Belongs to the methyltransferase superfamily
D2B33_08600	COG1199	ATP-dependent helicase activity
D2B33_08605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D2B33_08610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2B33_08615	COG2233	PERMEase
D2B33_08625	COG3424	synthase
D2B33_08630	COG1755	Isoprenylcysteine carboxyl methyltransferase
D2B33_08640	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D2B33_08650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D2B33_08660	COG0328	RNA-DNA hybrid ribonuclease activity
D2B33_08665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D2B33_08670	COG0328	RNA-DNA hybrid ribonuclease activity
D2B33_08690	COG1278	Cold shock
D2B33_08700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_08705	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D2B33_08710	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D2B33_08715	COG0386	Belongs to the glutathione peroxidase family
D2B33_08725	COG1413	lyase activity
D2B33_08730	COG0129	dihydroxy-acid dehydratase activity
D2B33_08740	COG2136	Putative SAM-dependent methyltransferase
D2B33_08740	COG2521	methyltransferase
D2B33_08750	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D2B33_08760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D2B33_08765	COG0204	Acyl-transferase
D2B33_08770	COG1272	protein, Hemolysin III
D2B33_08775	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D2B33_08780	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D2B33_08800	COG1999	signal sequence binding
D2B33_08805	COG2755	lipolytic protein G-D-S-L family
D2B33_08810	COG4698	Protein conserved in bacteria
D2B33_08825	COG0534	Mate efflux family protein
D2B33_08830	COG3706	GGDEF domain
D2B33_08840	COG1846	Transcriptional regulator
D2B33_08845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D2B33_08850	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D2B33_08875	COG0456	acetyltransferase
D2B33_08890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2B33_08895	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D2B33_08900	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D2B33_08905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2B33_08910	COG0456	acetyltransferase
D2B33_08915	COG1509	lysine 2,3-aminomutase activity
D2B33_08925	COG4479	Belongs to the UPF0346 family
D2B33_08940	COG0671	phosphoesterase, PA-phosphatase related
D2B33_08960	COG0701	Predicted permease
D2B33_08965	COG0813	purine-nucleoside phosphorylase activity
D2B33_08970	COG1876	peptidase activity
D2B33_08980	COG2226	methyltransferase
D2B33_08985	COG3409	Peptidoglycan-binding domain 1 protein
D2B33_08985	COG0793	Belongs to the peptidase S41A family
D2B33_08990	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_09000	COG0400	carboxylic ester hydrolase activity
D2B33_09005	COG0778	Nitroreductase
D2B33_09010	COG1733	regulation of RNA biosynthetic process
D2B33_09025	COG4305	rare lipoprotein A
D2B33_09035	COG2962	Rard protein
D2B33_09045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2B33_09050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D2B33_09055	COG0534	Mate efflux family protein
D2B33_09065	COG0791	NLP P60 protein
D2B33_09065	COG1388	LysM domain
D2B33_09070	COG2032	superoxide dismutase activity
D2B33_09075	COG0714	Associated with various cellular activities
D2B33_09080	COG4548	von Willebrand factor, type A
D2B33_09085	COG0567	Dehydrogenase, E1 component
D2B33_09090	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_09095	COG0385	Bile acid
D2B33_09100	COG0733	neurotransmitter:sodium symporter activity
D2B33_09110	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D2B33_09115	COG1657	PFAM Prenyltransferase squalene oxidase
D2B33_09135	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_09150	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2B33_09175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D2B33_09180	COG2318	DinB family
D2B33_09200	COG0574	Belongs to the PEP-utilizing enzyme family
D2B33_09200	COG3848	Pyruvate phosphate dikinase
D2B33_09210	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2B33_09215	COG1280	lysine exporter protein (LysE YggA)
D2B33_09230	COG2267	carboxylic ester hydrolase activity
D2B33_09245	COG0402	S-adenosylhomocysteine deaminase activity
D2B33_09270	COG2350	Protein conserved in bacteria
D2B33_09300	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D2B33_09315	COG5444	nuclease activity
D2B33_09330	COG3383	formate dehydrogenase (NAD+) activity
D2B33_09335	COG2427	Protein of unknown function (DUF1641)
D2B33_09345	COG2315	Protein conserved in bacteria
D2B33_09365	COG0514	ATP-dependent DNA helicase (RecQ)
D2B33_09370	COG3584	3D domain protein
D2B33_09370	COG1388	LysM domain
D2B33_09375	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_09380	COG1619	proteins homologs of microcin C7 resistance protein MccF
D2B33_09395	COG2322	membrane
D2B33_09400	COG0438	transferase activity, transferring glycosyl groups
D2B33_09415	COG1086	Polysaccharide biosynthesis protein
D2B33_09420	COG0741	lytic transglycosylase activity
D2B33_09425	COG0531	amino acid
D2B33_09440	COG0640	Transcriptional regulator
D2B33_09450	COG2378	regulation of single-species biofilm formation
D2B33_09460	COG3708	Transcriptional regulator
D2B33_09465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_09470	COG1309	transcriptional regulator
D2B33_09500	COG1846	Transcriptional regulator
D2B33_09505	COG1309	transcriptional regulator
D2B33_09515	COG1404	Belongs to the peptidase S8 family
D2B33_09520	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_09525	COG0840	transmembrane signaling receptor activity
D2B33_09535	COG0697	spore germination
D2B33_09540	COG0531	amino acid
D2B33_09545	COG0531	amino acid
D2B33_09555	COG0531	amino acid
D2B33_09560	COG2814	Major facilitator Superfamily
D2B33_09565	COG1846	Transcriptional regulator
D2B33_09570	COG0243	molybdopterin cofactor binding
D2B33_09575	COG0477	Major facilitator Superfamily
D2B33_09580	COG3848	Pyruvate phosphate dikinase
D2B33_09580	COG0574	Belongs to the PEP-utilizing enzyme family
D2B33_09585	COG0300	oxidoreductase activity
D2B33_09595	COG1132	(ABC) transporter
D2B33_09620	COG0583	DNA-binding transcription factor activity
D2B33_09625	COG0070	glutamate synthase
D2B33_09625	COG0067	glutamate synthase
D2B33_09625	COG0069	glutamate synthase activity
D2B33_09630	COG0493	'glutamate synthase
D2B33_09645	COG0463	Glycosyl transferase, family 2
D2B33_09650	COG2814	Major facilitator Superfamily
D2B33_09655	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_09660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_09665	COG1809	phosphosulfolactate synthase activity
D2B33_09670	COG0175	sulfate reduction
D2B33_09675	COG0306	phosphate transporter
D2B33_09680	COG2323	membrane
D2B33_09690	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2B33_09695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D2B33_09700	COG1733	regulation of RNA biosynthetic process
D2B33_09705	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_09710	COG1960	acyl-CoA dehydrogenase activity
D2B33_09715	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_09720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_09725	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_09730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_09735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_09740	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D2B33_09740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_09745	COG0439	Biotin carboxylase
D2B33_09750	COG0511	ligase activity, forming carbon-carbon bonds
D2B33_09755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D2B33_09760	COG1024	Enoyl-CoA hydratase
D2B33_09765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D2B33_09770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D2B33_09780	COG0166	Belongs to the GPI family
D2B33_09795	COG1252	NADH dehydrogenase
D2B33_09800	COG1309	transcriptional regulator
D2B33_09820	COG2027	D-alanyl-D-alanine carboxypeptidase
D2B33_09825	COG0438	transferase activity, transferring glycosyl groups
D2B33_09835	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D2B33_09840	COG2404	hydrolase activity, acting on ester bonds
D2B33_09845	COG1649	PFAM Uncharacterised BCR, COG1649
D2B33_09860	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D2B33_09865	COG0640	Transcriptional regulator
D2B33_09870	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D2B33_09875	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2B33_09880	COG1609	Transcriptional regulator
D2B33_09895	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D2B33_09910	COG1312	Catalyzes the dehydration of D-mannonate
D2B33_09915	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_09920	COG1725	Transcriptional regulator
D2B33_09935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_09935	COG3711	transcriptional antiterminator
D2B33_09955	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_09955	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_09955	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_09960	COG1482	cell wall glycoprotein biosynthetic process
D2B33_09965	COG1960	acyl-CoA dehydrogenase activity
D2B33_09970	COG2084	Dehydrogenase
D2B33_09975	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_09980	COG1024	Enoyl-CoA hydratase
D2B33_10010	COG1114	Component of the transport system for branched-chain amino acids
D2B33_10015	COG3420	alginic acid biosynthetic process
D2B33_10030	COG0492	ferredoxin-NADP+ reductase activity
D2B33_10050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D2B33_10060	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
D2B33_10080	COG2223	nitrite transmembrane transporter activity
D2B33_10085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2B33_10095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D2B33_10115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D2B33_10120	COG1140	nitrate reductase beta subunit
D2B33_10125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D2B33_10130	COG2181	nitrate reductase activity
D2B33_10140	COG1115	amino acid carrier protein
D2B33_10160	COG2160	L-arabinose isomerase activity
D2B33_10175	COG1609	Transcriptional regulator
D2B33_10180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2B33_10185	COG0187	DNA topoisomerase II activity
D2B33_10190	COG1832	CoA-binding protein
D2B33_10195	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D2B33_10200	COG4841	protein insertion into membrane
D2B33_10220	COG0824	Thioesterase
D2B33_10240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_10245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D2B33_10260	COG0071	Belongs to the small heat shock protein (HSP20) family
D2B33_10270	COG4846	Membrane protein involved in cytochrome C biogenesis
D2B33_10275	COG2201	protein-glutamate methylesterase activity
D2B33_10280	COG0785	Cytochrome C biogenesis protein
D2B33_10290	COG3763	UPF0154 protein
D2B33_10300	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D2B33_10305	COG4224	UPF0291 protein
D2B33_10310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D2B33_10315	COG1388	LysM domain
D2B33_10320	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D2B33_10330	COG3209	COG3209 Rhs family protein
D2B33_10335	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D2B33_10350	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2B33_10355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D2B33_10360	COG0346	lactoylglutathione lyase activity
D2B33_10365	COG1846	Transcriptional regulator
D2B33_10390	COG3546	catalase activity
D2B33_10395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_10410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_10415	COG2076	Multidrug Resistance protein
D2B33_10420	COG2076	Multidrug Resistance protein
D2B33_10425	COG1309	transcriptional regulator
D2B33_10465	COG1073	alpha beta
D2B33_10475	COG0475	glutathione-regulated potassium exporter activity
D2B33_10480	COG0490	domain, Protein
D2B33_10535	COG0174	glutamine synthetase
D2B33_10540	COG0789	Transcriptional regulator
D2B33_10545	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D2B33_10550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D2B33_10555	COG0464	growth
D2B33_10575	COG1695	Transcriptional regulator
D2B33_10585	COG0829	nickel cation binding
D2B33_10590	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D2B33_10595	COG0830	nickel cation binding
D2B33_10600	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D2B33_10610	COG0832	Belongs to the urease beta subunit family
D2B33_10615	COG0831	urea catabolic process
D2B33_10620	COG4413	Urea transporter
D2B33_10630	COG2732	(Barnase) inhibitor
D2B33_10650	COG0457	Tetratricopeptide repeat
D2B33_10655	COG2814	Major facilitator Superfamily
D2B33_10690	COG1309	transcriptional regulator
D2B33_10720	COG0697	spore germination
D2B33_10725	COG1802	Transcriptional regulator
D2B33_10745	COG4112	unkown
D2B33_10750	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2B33_10755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D2B33_10760	COG1780	Probably involved in ribonucleotide reductase function
D2B33_10775	COG1923	regulation of RNA biosynthetic process
D2B33_10780	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D2B33_10795	COG2076	Multidrug Resistance protein
D2B33_10800	COG2076	Multidrug Resistance protein
D2B33_10805	COG1764	response to oxidative stress
D2B33_10815	COG0702	epimerase
D2B33_10820	COG3631	Ketosteroid isomerase-related protein
D2B33_10825	COG1309	transcriptional regulator
D2B33_10830	COG3858	chitin binding
D2B33_10830	COG1388	LysM domain
D2B33_10840	COG5577	PFAM Coat F domain
D2B33_10845	COG0531	amino acid
D2B33_10850	COG1819	glycosyl
D2B33_10855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_10860	COG0398	Pfam SNARE associated Golgi protein
D2B33_10865	COG0393	Putative heavy-metal-binding
D2B33_10880	COG2814	Major facilitator Superfamily
D2B33_10885	COG3263	regulation of cellular component size
D2B33_10890	COG3619	membrane
D2B33_10895	COG1231	oxidoreductase activity
D2B33_10915	COG0523	cobalamin synthesis protein
D2B33_10930	COG0457	Tetratricopeptide repeat
D2B33_10955	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D2B33_10960	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D2B33_10965	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D2B33_10975	COG4550	Control of competence regulator ComK, YlbF/YmcA
D2B33_10980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D2B33_10985	COG0156	8-amino-7-oxononanoate synthase activity
D2B33_10990	COG1063	alcohol dehydrogenase
D2B33_11000	COG2359	stage V sporulation protein S
D2B33_11005	COG1692	metallophosphoesterase
D2B33_11010	COG1418	mRNA catabolic process
D2B33_11015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D2B33_11020	COG1546	Belongs to the CinA family
D2B33_11020	COG1058	Belongs to the CinA family
D2B33_11025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D2B33_11030	COG1426	Protein conserved in bacteria
D2B33_11045	COG0300	oxidoreductase activity
D2B33_11050	COG0612	Peptidase, M16
D2B33_11055	COG0612	Peptidase, M16
D2B33_11060	COG2814	Major facilitator Superfamily
D2B33_11065	COG2188	Transcriptional regulator
D2B33_11070	COG1674	ftsk spoiiie
D2B33_11070	COG4980	gas vesicle protein
D2B33_11080	COG0740	serine-type endopeptidase activity
D2B33_11085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D2B33_11095	COG0527	aspartate kinase activity
D2B33_11100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D2B33_11105	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2B33_11110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_11115	COG1873	PFAM PRC-barrel domain
D2B33_11120	COG0612	Peptidase, M16
D2B33_11125	COG0726	polysaccharide deacetylase
D2B33_11130	COG1185	polyribonucleotide nucleotidyltransferase activity
D2B33_11135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D2B33_11140	COG0196	riboflavin kinase activity
D2B33_11145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D2B33_11150	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D2B33_11155	COG1550	Protein conserved in bacteria
D2B33_11160	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D2B33_11165	COG1358	cellular component organization or biogenesis
D2B33_11170	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D2B33_11175	COG0195	Participates in both transcription termination and antitermination
D2B33_11180	COG0779	Required for maturation of 30S ribosomal subunits
D2B33_11205	COG2176	DNA-directed DNA polymerase activity
D2B33_11210	COG0442	prolyl-tRNA aminoacylation
D2B33_11215	COG0750	zinc metalloprotease
D2B33_11220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D2B33_11225	COG4589	Belongs to the CDS family
D2B33_11230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D2B33_11235	COG0233	cytoplasmic translational termination
D2B33_11240	COG0528	UMP kinase activity
D2B33_11245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D2B33_11250	COG0052	Belongs to the universal ribosomal protein uS2 family
D2B33_11260	COG1191	sigma factor activity
D2B33_11265	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D2B33_11270	COG1776	CheC inhibitor of MCP methylation
D2B33_11275	COG0835	chemotaxis
D2B33_11280	COG2198	Histidine kinase
D2B33_11280	COG0643	Histidine kinase
D2B33_11285	COG2201	protein-glutamate methylesterase activity
D2B33_11290	COG0455	bacterial-type flagellum organization
D2B33_11295	COG1419	protein localization to endoplasmic reticulum
D2B33_11300	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D2B33_11305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D2B33_11310	COG1684	flagellar biosynthetic protein fliR
D2B33_11315	COG1987	bacterial-type flagellum assembly
D2B33_11320	COG1338	Plays a role in the flagellum-specific transport system
D2B33_11325	COG3190	flagellar
D2B33_11330	COG2201	protein-glutamate methylesterase activity
D2B33_11335	COG1776	CheC inhibitor of MCP methylation
D2B33_11335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2B33_11340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2B33_11345	COG1580	Controls the rotational direction of flagella during chemotaxis
D2B33_11350	COG1582	Flagellar protein (FlbD)
D2B33_11355	COG4786	Flagellar basal body rod
D2B33_11360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D2B33_11365	COG3144	bacterial-type flagellum assembly
D2B33_11375	COG2882	bacterial-type flagellum organization
D2B33_11380	COG1157	protein secretion by the type III secretion system
D2B33_11385	COG1317	bacterial-type flagellum organization
D2B33_11390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D2B33_11400	COG1677	Flagellar hook-basal body complex protein FliE
D2B33_11405	COG1558	bacterial-type flagellum-dependent cell motility
D2B33_11410	COG1815	bacterial-type flagellum-dependent cell motility
D2B33_11415	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D2B33_11420	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D2B33_11425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D2B33_11430	COG4974	Belongs to the 'phage' integrase family
D2B33_11435	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D2B33_11440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2B33_11445	COG0758	DNA mediated transformation
D2B33_11450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2B33_11455	COG0045	succinate-CoA ligase (ADP-forming) activity
D2B33_11460	COG2257	FlhB HrpN YscU SpaS Family
D2B33_11470	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D2B33_11475	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D2B33_11480	COG0335	large ribosomal subunit rRNA binding
D2B33_11485	COG0336	Belongs to the RNA methyltransferase TrmD family
D2B33_11490	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D2B33_11500	COG1837	Belongs to the UPF0109 family
D2B33_11505	COG0228	four-way junction DNA binding
D2B33_11510	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D2B33_11515	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D2B33_11520	COG0552	protein localization to endoplasmic reticulum
D2B33_11525	COG1196	nuclear chromosome segregation
D2B33_11530	COG0571	ribonuclease III activity
D2B33_11535	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2B33_11540	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_11545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D2B33_11550	COG0416	fatty acid biosynthetic process
D2B33_11555	COG1349	DNA-binding transcription factor activity
D2B33_11560	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D2B33_11565	COG1760	l-serine dehydratase
D2B33_11570	COG1760	l-serine dehydratase
D2B33_11575	COG1461	Dihydroxyacetone kinase
D2B33_11580	COG1302	Protein conserved in bacteria
D2B33_11585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D2B33_11595	COG1564	THIamine pyrophosphokinase
D2B33_11600	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D2B33_11605	COG1162	GTPase activity
D2B33_11610	COG0515	serine threonine protein kinase
D2B33_11610	COG2815	serine threonine protein kinase
D2B33_11615	COG0631	protein serine/threonine phosphatase activity
D2B33_11620	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D2B33_11625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D2B33_11625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D2B33_11630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D2B33_11635	COG0242	peptide deformylase activity
D2B33_11640	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2B33_11645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D2B33_11650	COG1758	RNA polymerase activity
D2B33_11655	COG0194	GDP metabolic process
D2B33_11660	COG2052	Domain of unknown function (DUF370)
D2B33_11665	COG1561	YicC-like family, N-terminal region
D2B33_11670	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D2B33_11680	COG1648	precorrin-2 dehydrogenase activity
D2B33_11685	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D2B33_11690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D2B33_11695	COG0529	Catalyzes the synthesis of activated sulfate
D2B33_11700	COG2046	Belongs to the sulfate adenylyltransferase family
D2B33_11705	COG0306	phosphate transporter
D2B33_11710	COG0175	sulfate reduction
D2B33_11720	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D2B33_11725	COG0284	orotidine-5'-phosphate decarboxylase activity
D2B33_11730	COG0167	dihydroorotate dehydrogenase activity
D2B33_11735	COG0543	2 iron, 2 sulfur cluster binding
D2B33_11740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D2B33_11745	COG0505	Belongs to the CarA family
D2B33_11750	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D2B33_11755	COG0540	Belongs to the ATCase OTCase family
D2B33_11760	COG2233	PERMEase
D2B33_11765	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D2B33_11770	COG0564	pseudouridine synthase activity
D2B33_11775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D2B33_11780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D2B33_11785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D2B33_11790	COG3599	regulation of cell shape
D2B33_11795	COG2302	S4 RNA-binding domain
D2B33_11800	COG0762	integral membrane protein
D2B33_11805	COG1799	cell septum assembly
D2B33_11810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D2B33_11820	COG1873	PFAM PRC-barrel domain
D2B33_11825	COG0500	methyltransferase
D2B33_11830	COG1119	ATPase activity
D2B33_11835	COG1191	sigma factor activity
D2B33_11840	COG1191	sigma factor activity
D2B33_11850	COG1404	Belongs to the peptidase S8 family
D2B33_11850	COG4412	M6 family metalloprotease domain protein
D2B33_11855	COG4412	M6 family metalloprotease domain protein
D2B33_11855	COG1404	Belongs to the peptidase S8 family
D2B33_11860	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D2B33_11865	COG0849	cell division
D2B33_11870	COG3856	small basic protein
D2B33_11875	COG3879	Bacterial protein of unknown function (DUF881)
D2B33_11880	COG3879	Bacterial protein of unknown function (DUF881)
D2B33_11885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D2B33_11890	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D2B33_11895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D2B33_11900	COG0772	Belongs to the SEDS family
D2B33_11905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D2B33_11910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D2B33_11915	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D2B33_11920	COG0768	penicillin binding
D2B33_11930	COG4839	cell division protein FtsL
D2B33_11935	COG0275	rRNA processing
D2B33_11940	COG2001	Belongs to the MraZ family
D2B33_11945	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D2B33_11950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D2B33_11955	COG0454	-acetyltransferase
D2B33_11965	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D2B33_11970	COG1399	metal-binding, possibly nucleic acid-binding protein
D2B33_11975	COG1323	Belongs to the UPF0348 family
D2B33_11980	COG3480	Lon protease (S16) C-terminal proteolytic domain
D2B33_11985	COG3314	Sporulation integral membrane protein YlbJ
D2B33_11990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D2B33_11995	COG0742	ribosomal rna small subunit methyltransferase
D2B33_12000	COG4471	UPF0298 protein
D2B33_12005	COG3679	Belongs to the UPF0342 family
D2B33_12020	COG2340	Cysteine-rich secretory protein family
D2B33_12035	COG3336	cytochrome c oxidase
D2B33_12040	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D2B33_12045	COG1845	cytochrome c oxidase, subunit III
D2B33_12050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D2B33_12055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D2B33_12055	COG2010	Cytochrome c
D2B33_12060	COG0109	protoheme IX farnesyltransferase activity
D2B33_12065	COG1612	heme a metabolic process
D2B33_12070	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D2B33_12075	COG0772	Belongs to the SEDS family
D2B33_12080	COG4838	Belongs to the UPF0358 family
D2B33_12085	COG2066	Belongs to the glutaminase family
D2B33_12090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D2B33_12095	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D2B33_12105	COG4896	Protein conserved in bacteria
D2B33_12110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D2B33_12115	COG1846	Transcriptional regulator
D2B33_12140	COG1595	DNA-templated transcription, initiation
D2B33_12160	COG0483	inositol monophosphate 1-phosphatase activity
D2B33_12170	COG4493	Belongs to the UPF0637 family
D2B33_12175	COG4476	Belongs to the UPF0223 family
D2B33_12185	COG1982	Orn Lys Arg decarboxylase major
D2B33_12195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_12200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2B33_12205	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_12210	COG0022	dehydrogenase e1 component
D2B33_12215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2B33_12220	COG0497	DNA recombination
D2B33_12230	COG0242	peptide deformylase activity
D2B33_12235	COG0561	phosphatase activity
D2B33_12250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D2B33_12255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D2B33_12260	COG0569	domain protein
D2B33_12265	COG3852	Histidine kinase
D2B33_12270	COG2002	toxin-antitoxin pair type II binding
D2B33_12275	COG1077	Cell shape determining protein MreB Mrl
D2B33_12285	COG2309	aminopeptidase activity
D2B33_12295	COG0488	(ABC) transporter
D2B33_12315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_12315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D2B33_12315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_12320	COG1105	Belongs to the carbohydrate kinase PfkB family
D2B33_12325	COG1349	DNA-binding transcription factor activity
D2B33_12335	COG0577	efflux transmembrane transporter activity
D2B33_12340	COG1136	(ABC) transporter
D2B33_12345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D2B33_12355	COG1132	(ABC) transporter
D2B33_12360	COG1132	(ABC) transporter
D2B33_12370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D2B33_12375	COG0314	molybdopterin synthase activity
D2B33_12380	COG1763	Mo-molybdopterin cofactor biosynthetic process
D2B33_12385	COG0303	'Molybdopterin
D2B33_12390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2B33_12395	COG0746	molybdenum cofactor guanylyltransferase activity
D2B33_12410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_12415	COG0450	alkyl hydroperoxide reductase
D2B33_12425	COG1473	amidohydrolase
D2B33_12430	COG2171	N-acyltransferase activity
D2B33_12435	COG0716	FMN binding
D2B33_12445	COG0716	FMN binding
D2B33_12450	COG0583	DNA-binding transcription factor activity
D2B33_12455	COG0517	IMP dehydrogenase activity
D2B33_12465	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D2B33_12470	COG4703	Protein of unknown function (DUF1797)
D2B33_12485	COG2200	EAL domain
D2B33_12490	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_12495	COG1408	metallophosphoesterase
D2B33_12500	COG1376	ErfK ybiS ycfS ynhG family protein
D2B33_12505	COG2814	Major facilitator Superfamily
D2B33_12515	COG0784	Response regulator, receiver
D2B33_12515	COG0835	chemotaxis
D2B33_12525	COG1714	RDD family
D2B33_12530	COG0436	Aminotransferase
D2B33_12535	COG4191	Histidine kinase
D2B33_12540	COG0768	penicillin binding
D2B33_12545	COG2340	Cysteine-rich secretory protein family
D2B33_12550	COG2084	Dehydrogenase
D2B33_12555	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_12560	COG0840	transmembrane signaling receptor activity
D2B33_12565	COG0456	acetyltransferase
D2B33_12570	COG1533	DNA photolyase activity
D2B33_12580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D2B33_12585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_12590	COG2190	(PTS) system
D2B33_12590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_12590	COG1263	PTS System
D2B33_12595	COG3711	transcriptional antiterminator
D2B33_12600	COG1609	Transcriptional regulator
D2B33_12610	COG0006	proline dipeptidase activity
D2B33_12615	COG2217	Heavy metal translocating P-type atpase
D2B33_12620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_12625	COG2244	polysaccharide biosynthetic process
D2B33_12630	COG3773	Cell wall hydrolase
D2B33_12640	COG4873	Protein conserved in bacteria
D2B33_12675	COG3655	Transcriptional regulator
D2B33_12680	COG3739	integral membrane protein
D2B33_12685	COG0457	Tetratricopeptide repeat
D2B33_12695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D2B33_12700	COG0602	queuosine metabolic process
D2B33_12705	COG0720	synthase
D2B33_12710	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D2B33_12715	COG3949	Membrane
D2B33_12720	COG0542	response to heat
D2B33_12725	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D2B33_12730	COG1360	Flagellar Motor Protein
D2B33_12735	COG1846	Transcriptional regulator
D2B33_12740	COG3852	Histidine kinase
D2B33_12750	COG3339	Conserved Protein
D2B33_12755	COG0346	lactoylglutathione lyase activity
D2B33_12760	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D2B33_12765	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D2B33_12765	COG0235	Class ii aldolase
D2B33_12770	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D2B33_12770	COG0235	Class ii aldolase
D2B33_12775	COG1850	ribulose-bisphosphate carboxylase activity
D2B33_12780	COG0436	Aminotransferase
D2B33_12785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D2B33_12790	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D2B33_12795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D2B33_12800	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D2B33_12805	COG5002	protein histidine kinase activity
D2B33_12810	COG3594	Acyltransferase
D2B33_12825	COG0768	penicillin binding
D2B33_12830	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D2B33_12835	COG0501	Belongs to the peptidase M48B family
D2B33_12855	COG1191	sigma factor activity
D2B33_12860	COG0861	Integral membrane protein TerC family
D2B33_12865	COG0586	Pfam SNARE associated Golgi protein
D2B33_12870	COG5001	Diguanylate cyclase
D2B33_12870	COG3300	MHYT domain
D2B33_12875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D2B33_12880	COG3285	dna ligase
D2B33_12880	COG1793	dna ligase
D2B33_12885	COG1846	Transcriptional regulator
D2B33_12900	COG0789	Transcriptional regulator
D2B33_12910	COG2239	Acts as a magnesium transporter
D2B33_12920	COG1404	Belongs to the peptidase S8 family
D2B33_12925	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2B33_12940	COG0406	alpha-ribazole phosphatase activity
D2B33_12945	COG0590	tRNA wobble adenosine to inosine editing
D2B33_12955	COG1764	response to oxidative stress
D2B33_12960	COG1846	Transcriptional regulator
D2B33_12965	COG1764	response to oxidative stress
D2B33_12970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D2B33_12975	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D2B33_12985	COG0788	formyltetrahydrofolate deformylase activity
D2B33_12990	COG2076	Multidrug Resistance protein
D2B33_12995	COG2076	Multidrug Resistance protein
D2B33_13000	COG2318	DinB family
D2B33_13020	COG3866	Pectate lyase
D2B33_13025	COG2323	membrane
D2B33_13030	COG1607	acyl-coa hydrolase
D2B33_13035	COG1834	amidinotransferase
D2B33_13045	COG4608	Belongs to the ABC transporter superfamily
D2B33_13050	COG0791	NLP P60 protein
D2B33_13055	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_13060	COG1619	proteins homologs of microcin C7 resistance protein MccF
D2B33_13065	COG4166	transmembrane transport
D2B33_13070	COG0444	Belongs to the ABC transporter superfamily
D2B33_13075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_13080	COG0601	transmembrane transport
D2B33_13085	COG2362	D-Aminopeptidase
D2B33_13095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D2B33_13100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_13105	COG0346	lactoylglutathione lyase activity
D2B33_13110	COG0531	amino acid
D2B33_13115	COG0395	ABC-type sugar transport system, permease component
D2B33_13120	COG4209	transmembrane transport
D2B33_13125	COG1653	transport
D2B33_13135	COG1874	Beta-galactosidase
D2B33_13140	COG2755	lipolytic protein G-D-S-L family
D2B33_13145	COG0667	Aldo Keto reductase
D2B33_13150	COG3401	FG-GAP repeat protein
D2B33_13155	COG2755	lipolytic protein G-D-S-L family
D2B33_13165	COG3401	FG-GAP repeat protein
D2B33_13170	COG5578	integral membrane protein
D2B33_13180	COG2755	lipolytic protein G-D-S-L family
D2B33_13185	COG2207	Transcriptional regulator
D2B33_13190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D2B33_13195	COG0395	ABC-type sugar transport system, permease component
D2B33_13200	COG1175	transmembrane transport
D2B33_13205	COG1653	transport
D2B33_13210	COG4753	response regulator
D2B33_13210	COG2207	Transcriptional regulator
D2B33_13215	COG2972	Histidine kinase
D2B33_13220	COG5578	integral membrane protein
D2B33_13225	COG0405	Gamma-glutamyltransferase
D2B33_13230	COG1392	Phosphate transport regulator
D2B33_13235	COG0306	phosphate transporter
D2B33_13250	COG2271	Major facilitator Superfamily
D2B33_13255	COG1063	alcohol dehydrogenase
D2B33_13260	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_13265	COG1312	Catalyzes the dehydration of D-mannonate
D2B33_13270	COG1063	alcohol dehydrogenase
D2B33_13275	COG1802	Transcriptional regulator
D2B33_13285	COG3594	Acyltransferase
D2B33_13310	COG3778	Protein conserved in bacteria
D2B33_13315	COG3299	homolog of phage Mu protein gp47
D2B33_13320	COG3628	GPW Gp25 family protein
D2B33_13330	COG4193	domain, Protein
D2B33_13335	COG1652	LysM domain
D2B33_13340	COG3953	SLT domain
D2B33_13340	COG5280	Phage tail tape measure protein TP901
D2B33_13390	COG4653	Phage capsid family
D2B33_13395	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D2B33_13400	COG5518	Phage portal protein
D2B33_13405	COG1783	phage Terminase large subunit
D2B33_13410	COG5484	DNA packaging
D2B33_13410	COG3728	DNA packaging
D2B33_13415	COG1595	DNA-templated transcription, initiation
D2B33_13430	COG1484	DNA-dependent DNA replication
D2B33_13435	COG1522	sequence-specific DNA binding
D2B33_13450	COG1396	sequence-specific DNA binding
D2B33_13455	COG2856	Zn peptidase
D2B33_13460	COG4195	phage-related replication protein
D2B33_13475	COG1309	transcriptional regulator
D2B33_13480	COG2814	Major facilitator Superfamily
D2B33_13485	COG3584	3D domain protein
D2B33_13485	COG1388	LysM domain
D2B33_13495	COG0346	lactoylglutathione lyase activity
D2B33_13500	COG0697	spore germination
D2B33_13505	COG0583	DNA-binding transcription factor activity
D2B33_13510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2B33_13515	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D2B33_13520	COG0583	DNA-binding transcription factor activity
D2B33_13530	COG0110	maltose O-acetyltransferase activity
D2B33_13605	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_13615	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_13630	COG5505	Protein of unknown function (DUF819)
D2B33_13635	COG0626	cystathionine gamma-synthase activity
D2B33_13640	COG0626	cystathionine gamma-synthase activity
D2B33_13660	COG2382	esterase
D2B33_13665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D2B33_13670	COG2153	protein acetylation
D2B33_13675	COG2246	polysaccharide biosynthetic process
D2B33_13680	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D2B33_13685	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_13690	COG0586	Pfam SNARE associated Golgi protein
D2B33_13700	COG0210	DNA helicase
D2B33_13755	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D2B33_13760	COG0351	phosphomethylpyrimidine kinase
D2B33_13765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D2B33_13770	COG2022	thiamine diphosphate biosynthetic process
D2B33_13775	COG2104	thiamine diphosphate biosynthetic process
D2B33_13785	COG0352	thiamine-phosphate diphosphorylase activity
D2B33_13790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D2B33_13795	COG0569	domain protein
D2B33_13795	COG0475	glutathione-regulated potassium exporter activity
D2B33_13800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D2B33_13805	COG0564	pseudouridine synthase activity
D2B33_13810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D2B33_13815	COG2357	RelA SpoT domain protein
D2B33_13825	COG4116	CYTH
D2B33_13830	COG0741	lytic transglycosylase activity
D2B33_13835	COG2346	COG2346, Truncated hemoglobins
D2B33_13850	COG1164	Oligoendopeptidase f
D2B33_13855	COG4469	Competence protein
D2B33_13860	COG3290	protein histidine kinase activity
D2B33_13865	COG4565	transcriptional regulatory protein
D2B33_13890	COG4862	establishment of competence for transformation
D2B33_13900	COG0861	Integral membrane protein TerC family
D2B33_13905	COG1393	Belongs to the ArsC family
D2B33_13910	COG0456	acetyltransferase
D2B33_13915	COG4608	Belongs to the ABC transporter superfamily
D2B33_13920	COG0444	Belongs to the ABC transporter superfamily
D2B33_13925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_13930	COG0601	transmembrane transport
D2B33_13935	COG4166	transmembrane transport
D2B33_13945	COG0180	Tryptophanyl-tRNA synthetase
D2B33_13960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D2B33_13965	COG0601	transmembrane transport
D2B33_13975	COG4608	Belongs to the ABC transporter superfamily
D2B33_13980	COG0444	Belongs to the ABC transporter superfamily
D2B33_13985	COG5504	Zn-dependent protease
D2B33_13990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D2B33_13995	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2B33_14010	COG1744	ABC transporter substrate-binding protein PnrA-like
D2B33_14020	COG2267	carboxylic ester hydrolase activity
D2B33_14035	COG1968	undecaprenyl-diphosphatase activity
D2B33_14040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D2B33_14045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D2B33_14050	COG0505	Belongs to the CarA family
D2B33_14055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D2B33_14060	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D2B33_14065	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D2B33_14070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D2B33_14080	COG2151	metal-sulfur cluster biosynthetic enzyme
D2B33_14085	COG1073	alpha beta
D2B33_14090	COG0561	phosphatase activity
D2B33_14100	COG0516	GMP reductase activity
D2B33_14110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_14115	COG1307	EDD domain protein, DegV family
D2B33_14130	COG2996	Protein conserved in bacteria
D2B33_14135	COG1666	GTP binding
D2B33_14140	COG0646	methionine synthase
D2B33_14140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D2B33_14145	COG1410	methionine synthase
D2B33_14145	COG0646	methionine synthase
D2B33_14150	COG2378	regulation of single-species biofilm formation
D2B33_14155	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_14160	COG2153	protein acetylation
D2B33_14185	COG0076	glutamate decarboxylase activity
D2B33_14195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_14200	COG1279	arginine transmembrane transporter activity
D2B33_14205	COG0697	spore germination
D2B33_14220	COG0673	inositol 2-dehydrogenase activity
D2B33_14225	COG1609	Transcriptional regulator
D2B33_14235	COG2207	Transcriptional regulator
D2B33_14235	COG1917	Cupin 2, conserved barrel domain protein
D2B33_14240	COG0534	Mate efflux family protein
D2B33_14245	COG0347	Belongs to the P(II) protein family
D2B33_14250	COG0004	ammonium transporteR
D2B33_14255	COG0367	asparagine synthase
D2B33_14280	COG0179	Fumarylacetoacetate (FAA) hydrolase
D2B33_14290	COG5337	Spore coat protein CotH
D2B33_14335	COG0419	ATPase involved in DNA repair
D2B33_14340	COG0420	3'-5' exonuclease activity
D2B33_14345	COG1074	ATP-dependent DNA helicase activity
D2B33_14350	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D2B33_14355	COG4149	molybdate abc transporter
D2B33_14360	COG0725	ABC transporter, periplasmic molybdate-binding protein
D2B33_14365	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D2B33_14375	COG0745	RESPONSE REGULATOR receiver
D2B33_14380	COG5002	protein histidine kinase activity
D2B33_14390	COG4533	DNA binding
D2B33_14395	COG2814	Major facilitator Superfamily
D2B33_14395	COG0477	Major facilitator Superfamily
D2B33_14400	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_14405	COG3546	catalase activity
D2B33_14420	COG3180	Ammonia monooxygenase
D2B33_14425	COG1486	melibiose metabolic process
D2B33_14455	COG0457	Tetratricopeptide repeat
D2B33_14470	COG0549	Belongs to the carbamate kinase family
D2B33_14480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2B33_14485	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D2B33_14490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D2B33_14495	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D2B33_14500	COG3257	ureidoglycine aminohydrolase activity
D2B33_14505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D2B33_14510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D2B33_14515	COG2508	Transcriptional regulator
D2B33_14525	COG1404	Belongs to the peptidase S8 family
D2B33_14530	COG0681	Belongs to the peptidase S26 family
D2B33_14535	COG0398	Pfam SNARE associated Golgi protein
D2B33_14545	COG4903	ComK protein
D2B33_14555	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_14560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D2B33_14560	COG0723	plastoquinol--plastocyanin reductase activity
D2B33_14565	COG0840	transmembrane signaling receptor activity
D2B33_14570	COG0406	alpha-ribazole phosphatase activity
D2B33_14575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_14580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_14585	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D2B33_14590	COG0697	spore germination
D2B33_14600	COG0501	Belongs to the peptidase M48B family
D2B33_14615	COG1396	sequence-specific DNA binding
D2B33_14625	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_14630	COG0095	Lipoate-protein ligase
D2B33_14635	COG1234	tRNA 3'-trailer cleavage
D2B33_14645	COG1301	dicarboxylic acid transport
D2B33_14655	COG1363	Peptidase, m42
D2B33_14660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D2B33_14665	COG1511	domain protein
D2B33_14670	COG1309	transcriptional regulator
D2B33_14685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D2B33_14690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_14695	COG2329	Antibiotic biosynthesis monooxygenase
D2B33_14700	COG3069	C4-dicarboxylate transmembrane transporter activity
D2B33_14705	COG1473	amidohydrolase
D2B33_14715	COG4473	ABC transporter
D2B33_14720	COG1131	(ABC) transporter
D2B33_14730	COG0537	adenosine 5'-monophosphoramidase activity
D2B33_14735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D2B33_14750	COG4980	gas vesicle protein
D2B33_14755	COG1846	Transcriptional regulator
D2B33_14785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2B33_14795	COG3481	metal-dependent phosphohydrolase, HD sub domain
D2B33_14800	COG4717	serine-type aminopeptidase activity
D2B33_14805	COG0420	3'-5' exonuclease activity
D2B33_14810	COG1668	transmembrane transport
D2B33_14815	COG4152	abc transporter atp-binding protein
D2B33_14830	COG0457	Tetratricopeptide repeat
D2B33_14835	COG1024	Enoyl-CoA hydratase
D2B33_14845	COG0490	domain, Protein
D2B33_14850	COG0475	glutathione-regulated potassium exporter activity
D2B33_14855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D2B33_14860	COG0561	phosphatase activity
D2B33_14870	COG3679	Belongs to the UPF0342 family
D2B33_14875	COG4399	Belongs to the UPF0754 family
D2B33_14880	COG0189	ligase activity
D2B33_14885	COG0189	ligase activity
D2B33_14895	COG2508	Transcriptional regulator
D2B33_14900	COG3842	ATPase activity
D2B33_14915	COG0702	epimerase
D2B33_14920	COG1132	(ABC) transporter
D2B33_14925	COG1132	(ABC) transporter
D2B33_14930	COG0589	response to stress
D2B33_14955	COG2017	converts alpha-aldose to the beta-anomer
D2B33_14960	COG1757	Na H antiporter
D2B33_14970	COG0726	polysaccharide deacetylase
D2B33_14980	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D2B33_14985	COG0668	transmembrane transport
D2B33_14995	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_15000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D2B33_15005	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D2B33_15025	COG1253	flavin adenine dinucleotide binding
D2B33_15030	COG0789	Transcriptional regulator
D2B33_15035	COG1253	flavin adenine dinucleotide binding
D2B33_15050	COG3152	Membrane
D2B33_15055	COG0204	Acyl-transferase
D2B33_15060	COG0667	Aldo Keto reductase
D2B33_15065	COG0662	Cupin 2, conserved barrel domain protein
D2B33_15070	COG1595	DNA-templated transcription, initiation
D2B33_15090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_15095	COG3708	Transcriptional regulator
D2B33_15095	COG2207	Transcriptional regulator
D2B33_15125	COG0733	neurotransmitter:sodium symporter activity
D2B33_15130	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_15140	COG0372	Belongs to the citrate synthase family
D2B33_15145	COG0583	DNA-binding transcription factor activity
D2B33_15150	COG1388	LysM domain
D2B33_15150	COG0791	NLP P60 protein
D2B33_15155	COG2719	SpoVR family
D2B33_15160	COG1017	nitric oxide dioxygenase activity
D2B33_15160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D2B33_15165	COG1959	2 iron, 2 sulfur cluster binding
D2B33_15180	COG0431	NADPH-dependent FMN reductase
D2B33_15185	COG2197	response regulator
D2B33_15190	COG2203	Gaf domain
D2B33_15190	COG4585	Histidine kinase
D2B33_15205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2B33_15210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D2B33_15215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D2B33_15220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D2B33_15225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D2B33_15230	COG0604	alcohol dehydrogenase
D2B33_15245	COG2116	formate transmembrane transporter activity
D2B33_15250	COG0488	(ABC) transporter
D2B33_15255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D2B33_15255	COG3153	acetyltransferase
D2B33_15260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D2B33_15265	COG0517	IMP dehydrogenase activity
D2B33_15275	COG0564	pseudouridine synthase activity
D2B33_15280	COG3764	Sortase (surface protein transpeptidase)
D2B33_15285	COG4085	toxin activity
D2B33_15285	COG1525	nuclease
D2B33_15285	COG0737	Belongs to the 5'-nucleotidase family
D2B33_15290	COG5002	protein histidine kinase activity
D2B33_15300	COG5577	PFAM Coat F domain
D2B33_15325	COG1823	symporter activity
D2B33_15330	COG1464	Belongs to the NlpA lipoprotein family
D2B33_15335	COG2011	ABC-type metal ion transport system permease component
D2B33_15340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D2B33_15345	COG1278	Cold shock
D2B33_15350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2B33_15355	COG1131	(ABC) transporter
D2B33_15360	COG1131	(ABC) transporter
D2B33_15370	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2B33_15375	COG2814	Major facilitator Superfamily
D2B33_15380	COG1566	PFAM secretion protein HlyD family protein
D2B33_15385	COG2718	Belongs to the UPF0229 family
D2B33_15390	COG2766	serine protein kinase
D2B33_15395	COG1664	Polymer-forming cytoskeletal
D2B33_15400	COG1664	Polymer-forming cytoskeletal
D2B33_15405	COG0789	Transcriptional regulator
D2B33_15410	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D2B33_15420	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D2B33_15425	COG3382	B3 4 domain protein
D2B33_15435	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2B33_15455	COG1131	(ABC) transporter
D2B33_15465	COG1476	TRANSCRIPTIONal
D2B33_15475	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_15480	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D2B33_15485	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D2B33_15490	COG1116	anion transmembrane transporter activity
D2B33_15495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D2B33_15500	COG0710	3-dehydroquinate dehydratase activity
D2B33_15520	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D2B33_15525	COG0732	type I restriction modification DNA specificity domain
D2B33_15565	COG0457	Tetratricopeptide repeat
D2B33_15680	COG0735	belongs to the Fur family
D2B33_15685	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D2B33_15690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D2B33_15695	COG4129	membrane
D2B33_15715	COG0747	negative chemotaxis
D2B33_15720	COG4608	Belongs to the ABC transporter superfamily
D2B33_15725	COG0444	Belongs to the ABC transporter superfamily
D2B33_15730	COG1132	(ABC) transporter
D2B33_15735	COG3557	Belongs to the UPF0374 family
D2B33_15750	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_15760	COG1194	a g-specific adenine glycosylase
D2B33_15765	COG1988	membrane-bound metal-dependent
D2B33_15770	COG4485	Bacterial membrane protein, YfhO
D2B33_15780	COG0463	Glycosyl transferase, family 2
D2B33_15805	COG2137	regulation of response to DNA damage stimulus
D2B33_15810	COG1090	epimerase
D2B33_15830	COG0778	Nitroreductase
D2B33_15835	COG0384	phenazine biosynthesis protein PhzF
D2B33_15840	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D2B33_15840	COG0392	lysyltransferase activity
D2B33_15850	COG1051	belongs to the nudix hydrolase family
D2B33_15855	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_15860	COG1653	transport
D2B33_15870	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_15880	COG2514	catechol 2,3-dioxygenase activity
D2B33_15885	COG2259	Doxx family
D2B33_15890	COG1733	regulation of RNA biosynthetic process
D2B33_15905	COG1263	PTS System
D2B33_15905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_15910	COG1737	Transcriptional regulator
D2B33_15915	COG1486	melibiose metabolic process
D2B33_15920	COG1742	UPF0060 membrane protein
D2B33_15925	COG3284	Transcriptional regulator
D2B33_15930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D2B33_15935	COG0508	dehydrogenase complex catalyzes the overall conversion of
D2B33_15940	COG0022	dehydrogenase e1 component
D2B33_15945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D2B33_15955	COG5609	conserved protein (DUF2294)
D2B33_15960	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D2B33_15965	COG3002	Belongs to the UPF0753 family
D2B33_15970	COG0288	reversible hydration of carbon dioxide
D2B33_15975	COG3711	transcriptional antiterminator
D2B33_15980	COG1263	PTS System
D2B33_15980	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_15990	COG0477	Major facilitator Superfamily
D2B33_16000	COG1819	glycosyl
D2B33_16025	COG4637	Psort location Cytoplasmic, score
D2B33_16030	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2B33_16035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D2B33_16040	COG0598	Magnesium transport protein CorA
D2B33_16050	COG0371	Dehydrogenase
D2B33_16055	COG0726	polysaccharide deacetylase
D2B33_16065	COG0535	radical SAM domain protein
D2B33_16075	COG0387	Pfam Sodium calcium exchanger
D2B33_16085	COG0477	Major facilitator Superfamily
D2B33_16090	COG1295	ribonuclease BN
D2B33_16095	COG4980	gas vesicle protein
D2B33_16100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D2B33_16105	COG1115	amino acid carrier protein
D2B33_16110	COG4840	Belongs to the UPF0435 family
D2B33_16115	COG0693	protein deglycase activity
D2B33_16120	COG0737	Belongs to the 5'-nucleotidase family
D2B33_16125	COG0778	Nitroreductase
D2B33_16130	COG1733	regulation of RNA biosynthetic process
D2B33_16145	COG0673	inositol 2-dehydrogenase activity
D2B33_16155	COG0457	Tetratricopeptide repeat
D2B33_16155	COG0463	Glycosyl transferase, family 2
D2B33_16160	COG1215	transferase activity, transferring glycosyl groups
D2B33_16170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D2B33_16175	COG1045	serine acetyltransferase
D2B33_16180	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2B33_16205	COG2188	Transcriptional regulator
D2B33_16210	COG0366	Alpha amylase catalytic
D2B33_16215	COG1263	PTS System
D2B33_16215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_16220	COG1115	amino acid carrier protein
D2B33_16230	COG1368	sulfuric ester hydrolase activity
D2B33_16235	COG0024	Methionine aminopeptidase
D2B33_16245	COG2258	MOSC domain
D2B33_16250	COG1254	Belongs to the acylphosphatase family
D2B33_16255	COG0640	Transcriptional regulator
D2B33_16260	COG5658	integral membrane protein
D2B33_16265	COG3858	chitin binding
D2B33_16270	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D2B33_16280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D2B33_16310	COG0471	metal ion transport
D2B33_16325	COG2130	NADP-dependent
D2B33_16330	COG0513	Belongs to the DEAD box helicase family
D2B33_16335	COG0488	(ABC) transporter
D2B33_16345	COG2814	Major facilitator Superfamily
D2B33_16350	COG0789	Transcriptional regulator
D2B33_16360	COG2124	cytochrome p450
D2B33_16365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D2B33_16370	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D2B33_16375	COG0156	8-amino-7-oxononanoate synthase activity
D2B33_16380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D2B33_16385	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
D2B33_16390	COG0523	cobalamin synthesis protein
D2B33_16405	COG1469	GTP cyclohydrolase I activity
D2B33_16410	COG0640	Transcriptional regulator
D2B33_16420	COG0583	DNA-binding transcription factor activity
D2B33_16425	COG0488	(ABC) transporter
D2B33_16430	COG0471	metal ion transport
D2B33_16435	COG1309	transcriptional regulator
D2B33_16440	COG0109	protoheme IX farnesyltransferase activity
D2B33_16445	COG0840	transmembrane signaling receptor activity
D2B33_16450	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_16480	COG0217	transcriptional regulatory protein
D2B33_16485	COG0697	spore germination
D2B33_16490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_16495	COG0697	spore germination
D2B33_16500	COG3586	endonuclease activity
D2B33_16505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2B33_16505	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
D2B33_16520	COG0457	Tetratricopeptide repeat
D2B33_16525	COG3711	transcriptional antiterminator
D2B33_16560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D2B33_16565	COG1597	lipid kinase activity
D2B33_16570	COG1957	nucleoside hydrolase
D2B33_16575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_16585	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D2B33_16590	COG1309	transcriptional regulator
D2B33_16595	COG4124	Belongs to the glycosyl hydrolase 26 family
D2B33_16610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D2B33_16615	COG0154	amidase activity
D2B33_16620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D2B33_16625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_16630	COG1285	pathogenesis
D2B33_16635	COG0363	glucosamine-6-phosphate deaminase activity
D2B33_16640	COG3457	Alanine racemase
D2B33_16645	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D2B33_16650	COG0626	cystathionine gamma-synthase activity
D2B33_16655	COG1735	metal-dependent hydrolase with the TIM-barrel fold
D2B33_16675	COG2188	Transcriptional regulator
D2B33_16680	COG4851	CamS sex pheromone cAM373 precursor
D2B33_16685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D2B33_16690	COG0210	DNA helicase
D2B33_16695	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D2B33_16700	COG4496	protein, YerC YecD
D2B33_16705	COG1470	cell adhesion involved in biofilm formation
D2B33_16710	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D2B33_16735	COG2124	cytochrome p450
D2B33_16745	COG0151	Belongs to the GarS family
D2B33_16750	COG0138	bifunctional purine biosynthesis protein purh
D2B33_16755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D2B33_16760	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D2B33_16765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D2B33_16770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D2B33_16775	COG0047	phosphoribosylformylglycinamidine synthase activity
D2B33_16780	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D2B33_16785	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D2B33_16790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D2B33_16795	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D2B33_16800	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D2B33_16810	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D2B33_16825	COG2252	PERMEase
D2B33_16835	COG0519	Catalyzes the synthesis of GMP from XMP
D2B33_16835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D2B33_16840	COG1305	Transglutaminase-like
D2B33_16845	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D2B33_16850	COG0714	Associated with various cellular activities
D2B33_16855	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D2B33_16875	COG2132	Multicopper oxidase
D2B33_16885	COG0702	epimerase
D2B33_16915	COG0823	Involved in the tonB-independent uptake of proteins
D2B33_16920	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D2B33_16935	COG1846	Transcriptional regulator
D2B33_16940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D2B33_16945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D2B33_16950	COG0366	Alpha amylase catalytic
D2B33_16955	COG1554	hydrolase, family 65, central catalytic
D2B33_16960	COG5521	maltodextrose utilization protein MalA
D2B33_16965	COG3833	ABC-type maltose transport systems, permease component
D2B33_16970	COG1175	transmembrane transport
D2B33_16975	COG2182	Extracellular solute-binding protein
D2B33_16980	COG0366	Alpha amylase catalytic
D2B33_16985	COG1609	Transcriptional regulator
D2B33_17000	COG0726	polysaccharide deacetylase
D2B33_17020	COG0772	Belongs to the SEDS family
D2B33_17025	COG0772	Belongs to the SEDS family
D2B33_17030	COG3339	Conserved Protein
D2B33_17035	COG1280	lysine exporter protein (LysE YggA)
D2B33_17040	COG1378	Sugar-specific transcriptional regulator TrmB
D2B33_17050	COG4260	virion core protein, lumpy skin disease virus
D2B33_17055	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D2B33_17060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D2B33_17065	COG1842	Phage shock protein A
D2B33_17070	COG2814	Major facilitator Superfamily
D2B33_17075	COG2272	Belongs to the type-B carboxylesterase lipase family
D2B33_17080	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D2B33_17095	COG0574	Belongs to the PEP-utilizing enzyme family
D2B33_17095	COG3848	Pyruvate phosphate dikinase
D2B33_17100	COG1309	transcriptional regulator
D2B33_17110	COG2135	peptidase activity
D2B33_17130	COG2720	vancomycin resistance protein
D2B33_17140	COG0459	protein refolding
D2B33_17145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D2B33_17150	COG1266	CAAX protease self-immunity
D2B33_17160	COG0805	protein transport
D2B33_17165	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D2B33_17170	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D2B33_17175	COG0315	cyclic pyranopterin monophosphate synthase activity
D2B33_17180	COG0488	(ABC) transporter
D2B33_17185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D2B33_17190	COG0456	acetyltransferase
D2B33_17195	COG1214	PFAM Peptidase M22, glycoprotease
D2B33_17200	COG0802	atpase or kinase
D2B33_17205	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D2B33_17245	COG2814	Major facilitator Superfamily
D2B33_17255	COG3764	Sortase (surface protein transpeptidase)
D2B33_17265	COG3279	Response regulator of the LytR AlgR family
D2B33_17270	COG0745	RESPONSE REGULATOR receiver
D2B33_17270	COG2972	Histidine kinase
D2B33_17275	COG1979	alcohol dehydrogenase
D2B33_17280	COG2814	Major facilitator Superfamily
D2B33_17285	COG0494	nUDIX hydrolase
D2B33_17290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D2B33_17290	COG2755	lipolytic protein G-D-S-L family
D2B33_17300	COG1595	DNA-templated transcription, initiation
D2B33_17305	COG5566	PFAM Mor transcription activator
D2B33_17310	COG0596	Alpha beta hydrolase
D2B33_17325	COG1113	amino acid transport
D2B33_17330	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D2B33_17345	COG1733	regulation of RNA biosynthetic process
D2B33_17350	COG3545	Serine hydrolase
D2B33_17385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_17390	COG1733	regulation of RNA biosynthetic process
D2B33_17400	COG2808	Putative FMN-binding domain
D2B33_17405	COG0456	acetyltransferase
D2B33_17410	COG1846	Transcriptional regulator
D2B33_17415	COG2364	Membrane
D2B33_17450	COG1278	Cold shock
D2B33_17455	COG3239	Fatty acid desaturase
D2B33_17460	COG1476	TRANSCRIPTIONal
D2B33_17470	COG0726	polysaccharide deacetylase
D2B33_17510	COG3091	SprT-like family
D2B33_17520	COG1033	growth of symbiont in host cell
D2B33_17520	COG2409	Drug exporters of the RND superfamily
D2B33_17530	COG1309	transcriptional regulator
D2B33_17535	COG2183	response to ionizing radiation
D2B33_17540	COG2208	phosphoserine phosphatase activity
D2B33_17545	COG1191	sigma factor activity
D2B33_17560	COG2208	phosphoserine phosphatase activity
D2B33_17565	COG2172	sigma factor antagonist activity
D2B33_17570	COG1366	Belongs to the anti-sigma-factor antagonist family
D2B33_17575	COG1366	Belongs to the anti-sigma-factor antagonist family
D2B33_17580	COG2337	Toxic component of a toxin-antitoxin (TA) module
D2B33_17585	COG0864	Transcriptional regulator
D2B33_17590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D2B33_17595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D2B33_17600	COG0705	Rhomboid family
D2B33_17605	COG3428	Bacterial PH domain
D2B33_17610	COG3402	PFAM membrane-flanked domain
D2B33_17615	COG0513	Belongs to the DEAD box helicase family
D2B33_17625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D2B33_17630	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2B33_17635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D2B33_17650	COG1960	acyl-CoA dehydrogenase activity
D2B33_17660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2B33_17665	COG1131	(ABC) transporter
D2B33_17670	COG1301	dicarboxylic acid transport
D2B33_17675	COG0628	permease
D2B33_17685	COG0662	Cupin 2, conserved barrel domain protein
D2B33_17695	COG2217	Heavy metal translocating P-type atpase
D2B33_17700	COG4876	unkown
D2B33_17705	COG1819	glycosyl
D2B33_17710	COG1027	Aspartate ammonia-lyase
D2B33_17715	COG2261	transglycosylase associated protein
D2B33_17720	COG1914	H( )-stimulated, divalent metal cation uptake system
D2B33_17725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D2B33_17735	COG3397	chitin binding
D2B33_17740	COG0028	Belongs to the TPP enzyme family
D2B33_17750	COG1605	Chorismate mutase
D2B33_17755	COG0512	Glutamine amidotransferase of anthranilate synthase
D2B33_17755	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2B33_17760	COG0287	Prephenate dehydrogenase
D2B33_17765	COG0551	DNA topoisomerase type I activity
D2B33_17765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D2B33_17770	COG1522	sequence-specific DNA binding
D2B33_17780	COG2814	Major facilitator Superfamily
D2B33_17785	COG1316	TRANSCRIPTIONal
D2B33_17800	COG3871	stress protein (general stress protein 26)
D2B33_17810	COG1917	Cupin 2, conserved barrel domain protein
D2B33_17815	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_17820	COG3711	transcriptional antiterminator
D2B33_17830	COG0246	Mannitol dehydrogenase
D2B33_17835	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_17840	COG2213	PTS system mannitol-specific
D2B33_17850	COG2755	lipolytic protein G-D-S-L family
D2B33_17855	COG1414	Transcriptional regulator
D2B33_17860	COG1984	allophanate hydrolase subunit 2
D2B33_17865	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D2B33_17870	COG4336	lyase activity
D2B33_17875	COG1914	H( )-stimulated, divalent metal cation uptake system
D2B33_17880	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D2B33_17885	COG0561	phosphatase activity
D2B33_17890	COG3958	Transketolase
D2B33_17895	COG3959	Transketolase, thiamine diphosphate binding domain
D2B33_17910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_17920	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D2B33_17925	COG0471	metal ion transport
D2B33_17930	COG1802	Transcriptional regulator
D2B33_17935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D2B33_17935	COG1587	Uroporphyrinogen-III synthase
D2B33_17940	COG2146	nitrite reductase [NAD(P)H] activity
D2B33_17945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2B33_17950	COG0243	molybdopterin cofactor binding
D2B33_17955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D2B33_17960	COG1349	DNA-binding transcription factor activity
D2B33_17965	COG2372	response to copper ion
D2B33_17965	COG1276	copper resistance
D2B33_17970	COG4549	nuclear export factor GLE1
D2B33_17980	COG0697	spore germination
D2B33_17985	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_17990	COG0531	amino acid
D2B33_17995	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D2B33_18000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_18005	COG0640	Transcriptional regulator
D2B33_18010	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D2B33_18015	COG0778	Nitroreductase
D2B33_18025	COG1309	transcriptional regulator
D2B33_18030	COG2814	Major facilitator Superfamily
D2B33_18035	COG4607	ABC-type enterochelin transport system periplasmic component
D2B33_18040	COG4604	ABC transporter, ATP-binding protein
D2B33_18045	COG4605	iron ion homeostasis
D2B33_18050	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_18055	COG0527	aspartate kinase activity
D2B33_18060	COG0840	transmembrane signaling receptor activity
D2B33_18065	COG5002	protein histidine kinase activity
D2B33_18065	COG3850	Histidine kinase
D2B33_18070	COG0745	RESPONSE REGULATOR receiver
D2B33_18075	COG0577	efflux transmembrane transporter activity
D2B33_18080	COG1136	(ABC) transporter
D2B33_18085	COG0789	Transcriptional regulator
D2B33_18090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D2B33_18100	COG0697	spore germination
D2B33_18110	COG5434	Belongs to the glycosyl hydrolase 28 family
D2B33_18115	COG3104	oligopeptide transport
D2B33_18125	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D2B33_18130	COG1874	Beta-galactosidase
D2B33_18135	COG0456	acetyltransferase
D2B33_18135	COG1846	Transcriptional regulator
D2B33_18140	COG2271	Major facilitator Superfamily
D2B33_18145	COG4214	carbohydrate transport
D2B33_18155	COG4213	ABC transporter substrate-binding protein
D2B33_18160	COG2207	Transcriptional regulator
D2B33_18160	COG4753	response regulator
D2B33_18165	COG2972	Histidine kinase
D2B33_18255	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D2B33_18260	COG0163	prenyltransferase activity
D2B33_18265	COG0583	DNA-binding transcription factor activity
D2B33_18270	COG0010	Belongs to the arginase family
D2B33_18275	COG0833	amino acid
D2B33_18280	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D2B33_18285	COG3829	transcription factor binding
D2B33_18290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2B33_18295	COG0765	amino acid transport
D2B33_18300	COG1126	abc transporter atp-binding protein
D2B33_18330	COG2364	Membrane
D2B33_18335	COG2207	Transcriptional regulator
D2B33_18335	COG3708	Transcriptional regulator
D2B33_18340	COG2819	hydrolase of the alpha beta superfamily
D2B33_18350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_18355	COG0697	spore germination
D2B33_18360	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D2B33_18365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_18370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_18375	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_18385	COG1177	transmembrane transport
D2B33_18390	COG1176	ABC-type spermidine putrescine transport system, permease component I
D2B33_18415	COG5444	nuclease activity
D2B33_18425	COG3209	COG3209 Rhs family protein
D2B33_18435	COG2723	6-phospho-beta-galactosidase activity
D2B33_18440	COG1116	anion transmembrane transporter activity
D2B33_18445	COG2249	NAD(P)H dehydrogenase (quinone) activity
D2B33_18450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D2B33_18455	COG0765	amino acid transport
D2B33_18475	COG3458	cephalosporin-C deacetylase activity
D2B33_18480	COG0701	Predicted permease
D2B33_18485	COG3689	TIGRFAM TIGR03943 family protein
D2B33_18490	COG2508	Transcriptional regulator
D2B33_18495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_18500	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_18505	COG0506	proline dehydrogenase activity
D2B33_18510	COG3541	Predicted nucleotidyltransferase
D2B33_18515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D2B33_18520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D2B33_18525	COG1113	amino acid transport
D2B33_18530	COG1280	lysine exporter protein (LysE YggA)
D2B33_18535	COG1620	l-lactate permease
D2B33_18540	COG0039	L-malate dehydrogenase activity
D2B33_18545	COG2223	nitrite transmembrane transporter activity
D2B33_18555	COG0785	Cytochrome C biogenesis protein
D2B33_18560	COG3853	Toxic anion resistance protein (TelA)
D2B33_18580	COG0861	Integral membrane protein TerC family
D2B33_18585	COG2310	stress, protein
D2B33_18590	COG2310	stress, protein
D2B33_18595	COG2310	stress, protein
D2B33_18610	COG1309	transcriptional regulator
D2B33_18615	COG1131	(ABC) transporter
D2B33_18625	COG0791	NLP P60 protein
D2B33_18625	COG3883	PFAM NLP P60 protein
D2B33_18630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_18635	COG3773	Cell wall hydrolase
D2B33_18645	COG1595	DNA-templated transcription, initiation
D2B33_18655	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_18660	COG3591	Belongs to the peptidase S1B family
D2B33_18675	COG3394	polysaccharide catabolic process
D2B33_18685	COG1486	melibiose metabolic process
D2B33_18690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_18695	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_18700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_18705	COG0277	FAD linked oxidase domain protein
D2B33_18710	COG0247	lactate metabolic process
D2B33_18720	COG2261	transglycosylase associated protein
D2B33_18725	COG1164	Oligoendopeptidase f
D2B33_18735	COG0456	acetyltransferase
D2B33_18740	COG0252	asparaginase activity
D2B33_18750	COG1288	antiporter activity
D2B33_18765	COG1028	Short-chain dehydrogenase reductase Sdr
D2B33_18770	COG1942	4-Oxalocrotonate Tautomerase
D2B33_18775	COG0583	DNA-binding transcription factor activity
D2B33_18805	COG1405	negative regulation of cell septum assembly
D2B33_18805	COG3012	SEC-C Motif Domain Protein
D2B33_18815	COG0697	spore germination
D2B33_18840	COG0789	Transcriptional regulator
D2B33_18860	COG0318	PFAM AMP-dependent synthetase and ligase
D2B33_18865	COG1846	Transcriptional regulator
D2B33_18870	COG3173	Aminoglycoside phosphotransferase
D2B33_18895	COG1131	(ABC) transporter
D2B33_18900	COG2205	protein histidine kinase activity
D2B33_18905	COG0745	RESPONSE REGULATOR receiver
D2B33_18925	COG2721	sulfolactate sulfo-lyase activity
D2B33_18930	COG2186	Transcriptional regulator
D2B33_18935	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_18940	COG2271	Major facilitator Superfamily
D2B33_18945	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_18950	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D2B33_18955	COG0805	protein transport
D2B33_18960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D2B33_18965	COG3540	Alkaline phosphatase
D2B33_18990	COG0784	Response regulator, receiver
D2B33_18995	COG4191	Histidine kinase
D2B33_19000	COG2066	Belongs to the glutaminase family
D2B33_19005	COG1115	amino acid carrier protein
D2B33_19010	COG2205	protein histidine kinase activity
D2B33_19025	COG2323	membrane
D2B33_19030	COG0789	Transcriptional regulator
D2B33_19035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_19035	COG1263	PTS System
D2B33_19045	COG2040	homocysteine
D2B33_19050	COG0833	amino acid
D2B33_19060	COG4257	antibiotic catabolic process
D2B33_19075	COG0371	Dehydrogenase
D2B33_19090	COG2197	response regulator
D2B33_19100	COG2207	Transcriptional regulator
D2B33_19100	COG1917	Cupin 2, conserved barrel domain protein
D2B33_19105	COG0697	spore germination
D2B33_19130	COG4682	membrane
D2B33_19135	COG1283	sodium-dependent phosphate transmembrane transporter activity
D2B33_19155	COG0730	response to heat
D2B33_19160	COG1802	Transcriptional regulator
D2B33_19165	COG0778	Nitroreductase
D2B33_19170	COG0076	glutamate decarboxylase activity
D2B33_19175	COG2226	methyltransferase
D2B33_19205	COG0789	Transcriptional regulator
D2B33_19210	COG0697	spore germination
D2B33_19215	COG1331	Highly conserved protein containing a thioredoxin domain
D2B33_19235	COG2211	Major facilitator Superfamily
D2B33_19255	COG1011	Hydrolase
D2B33_19275	COG2312	Erythromycin esterase
D2B33_19280	COG1132	(ABC) transporter
D2B33_19290	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D2B33_19295	COG1132	(ABC) transporter
D2B33_19310	COG1309	transcriptional regulator
D2B33_19315	COG2814	Major facilitator Superfamily
D2B33_19325	COG0640	Transcriptional regulator
D2B33_19330	COG1725	Transcriptional regulator
D2B33_19350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D2B33_19355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D2B33_19360	COG4856	YbbR-like protein
D2B33_19365	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D2B33_19370	COG5662	AntiSigma factor
D2B33_19375	COG1595	DNA-templated transcription, initiation
D2B33_19410	COG1683	Conserved Protein
D2B33_19415	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D2B33_19420	COG1737	Transcriptional regulator
D2B33_19425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_19425	COG1263	PTS System
D2B33_19430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_19435	COG1472	Belongs to the glycosyl hydrolase 3 family
D2B33_19440	COG3876	Protein conserved in bacteria
D2B33_19455	COG0385	Bile acid
D2B33_19465	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D2B33_19495	COG0726	polysaccharide deacetylase
D2B33_19500	COG2194	sulfuric ester hydrolase activity
D2B33_19510	COG0489	protein tyrosine kinase activity
D2B33_19515	COG0860	N-Acetylmuramoyl-L-alanine amidase
D2B33_19540	COG3290	protein histidine kinase activity
D2B33_19565	COG2274	protein secretion by the type I secretion system
D2B33_19595	COG1131	(ABC) transporter
D2B33_19615	COG2318	DinB family
D2B33_19645	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D2B33_19650	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D2B33_19655	COG0101	tRNA pseudouridine synthase activity
D2B33_19660	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2B33_19665	COG1122	ATPase activity
D2B33_19670	COG1122	ATPase activity
D2B33_19675	COG0203	ribosomal protein L17
D2B33_19680	COG0202	RNA polymerase activity
D2B33_19685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D2B33_19690	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D2B33_19695	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D2B33_19700	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D2B33_19705	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D2B33_19710	COG0024	Methionine aminopeptidase
D2B33_19715	COG0563	adenylate kinase activity
D2B33_19720	COG0201	protein transport
D2B33_19725	COG0200	Binds to the 23S rRNA
D2B33_19730	COG1841	ribosomal large subunit assembly
D2B33_19735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D2B33_19740	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D2B33_19745	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D2B33_19750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D2B33_19755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D2B33_19760	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D2B33_19765	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D2B33_19770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D2B33_19775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D2B33_19780	COG0255	Belongs to the universal ribosomal protein uL29 family
D2B33_19785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D2B33_19790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D2B33_19795	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D2B33_19800	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D2B33_19810	COG0089	rRNA binding
D2B33_19815	COG0088	Forms part of the polypeptide exit tunnel
D2B33_19820	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D2B33_19825	COG0051	transcription antitermination factor activity, RNA binding
D2B33_19830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D2B33_19835	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D2B33_19840	COG0049	tRNA binding
D2B33_19845	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D2B33_19850	COG1358	cellular component organization or biogenesis
D2B33_19855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D2B33_19860	COG0085	RNA polymerase activity
D2B33_19865	COG2813	Specifically methylates the guanine in position
D2B33_19870	COG0222	ribosome binding
D2B33_19875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D2B33_19880	COG0081	regulation of translation
D2B33_19885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D2B33_19890	COG0250	Participates in transcription elongation, termination and antitermination
D2B33_19910	COG3688	RNA-binding protein containing a PIN domain
D2B33_19915	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D2B33_19920	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D2B33_19925	COG0215	cysteine-tRNA ligase activity
D2B33_19930	COG1045	serine acetyltransferase
D2B33_19935	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D2B33_19940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D2B33_19945	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D2B33_19950	COG4956	integral membrane protein (PIN domain superfamily)
D2B33_19955	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D2B33_19960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D2B33_19965	COG0542	response to heat
D2B33_19970	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D2B33_19975	COG3880	PFAM UvrB UvrC protein
D2B33_19980	COG4463	regulation of RNA biosynthetic process
D2B33_20060	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D2B33_20065	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D2B33_20070	COG1396	sequence-specific DNA binding
D2B33_20075	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D2B33_20080	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D2B33_20085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D2B33_20090	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2B33_20095	COG0512	Glutamine amidotransferase of anthranilate synthase
D2B33_20100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D2B33_20110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D2B33_20115	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D2B33_20120	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D2B33_20125	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D2B33_20130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D2B33_20140	COG0037	tRNA processing
D2B33_20145	COG0515	serine threonine protein kinase
D2B33_20150	COG2304	oxidoreductase activity
D2B33_20155	COG2208	phosphoserine phosphatase activity
D2B33_20170	COG1098	S1 RNA binding domain
D2B33_20175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D2B33_20190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D2B33_20195	COG3956	TIGRFAM MazG family protein
D2B33_20200	COG2244	polysaccharide biosynthetic process
D2B33_20205	COG2002	toxin-antitoxin pair type II binding
D2B33_20210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D2B33_20220	COG0193	aminoacyl-tRNA hydrolase activity
D2B33_20225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D2B33_20230	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D2B33_20235	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D2B33_20240	COG2088	sporulation resulting in formation of a cellular spore
D2B33_20245	COG0251	oxidation-reduction process
D2B33_20250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D2B33_20255	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D2B33_20265	COG4466	Protein conserved in bacteria
D2B33_20275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D2B33_20280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D2B33_20285	COG3584	3D domain protein
D2B33_20285	COG3583	domain protein
D2B33_20290	COG0084	hydrolase, TatD family'
D2B33_20295	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_20295	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D2B33_20300	COG2002	toxin-antitoxin pair type II binding
D2B33_20305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D2B33_20310	COG2827	Endonuclease containing a URI domain
D2B33_20315	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D2B33_20320	COG4467	Involved in initiation control of chromosome replication
D2B33_20325	COG1774	PSP1 C-terminal conserved region
D2B33_20330	COG0470	DNA polymerase III
D2B33_20335	COG1728	Protein conserved in bacteria
D2B33_20340	COG3870	Protein conserved in bacteria
D2B33_20345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D2B33_20350	COG1982	Orn Lys Arg decarboxylase major
D2B33_20355	COG3853	Toxic anion resistance protein (TelA)
D2B33_20360	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D2B33_20405	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D2B33_20410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D2B33_20415	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D2B33_20425	COG0590	tRNA wobble adenosine to inosine editing
D2B33_20430	COG1335	isochorismatase
D2B33_20435	COG1388	LysM domain
D2B33_20435	COG3858	chitin binding
D2B33_20440	COG1428	Deoxynucleoside kinase
D2B33_20445	COG1428	Deoxynucleoside kinase
D2B33_20460	COG3835	regulator
D2B33_20465	COG2610	gluconate transmembrane transporter activity
D2B33_20470	COG1929	Belongs to the glycerate kinase type-1 family
D2B33_20475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D2B33_20480	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D2B33_20485	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D2B33_20490	COG1686	Belongs to the peptidase S11 family
D2B33_20495	COG0517	IMP dehydrogenase activity
D2B33_20495	COG0516	GMP reductase activity
D2B33_20530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D2B33_20535	COG0187	DNA topoisomerase II activity
D2B33_20545	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D2B33_20550	COG2501	S4 domain
D2B33_20555	COG0592	DNA-directed DNA polymerase activity
D2B33_20560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D2B33_20565	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D2B33_20570	COG0594	ribonuclease P activity
D2B33_20575	COG0706	membrane insertase activity
D2B33_20580	COG1847	R3H domain protein
D2B33_20585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D2B33_20590	COG0445	tRNA wobble uridine modification
D2B33_20595	COG0357	Ribosomal RNA small subunit methyltransferase G
D2B33_20600	COG1475	DNA binding
D2B33_20605	COG1595	DNA-templated transcription, initiation
D2B33_20610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D2B33_20615	COG1192	Involved in chromosome partitioning
D2B33_20620	COG1475	DNA binding
D2B33_20630	COG3949	Membrane
D2B33_20635	COG4481	Protein conserved in bacteria
D2B33_20645	COG0012	GTP binding
D2B33_20650	COG0360	Binds together with S18 to 16S ribosomal RNA
D2B33_20655	COG0629	single-stranded DNA binding
D2B33_20660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D2B33_20665	COG2271	Major facilitator Superfamily
D2B33_20670	COG0659	secondary active sulfate transmembrane transporter activity
D2B33_20675	COG0589	response to stress
D2B33_20680	COG5577	PFAM Coat F domain
D2B33_20685	COG4241	membrane
D2B33_20690	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D2B33_20695	COG0359	binds to the 23S rRNA
D2B33_20700	COG1263	PTS System
D2B33_20700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_20705	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D2B33_20715	COG0363	glucosamine-6-phosphate deaminase activity
D2B33_20720	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D2B33_20725	COG2807	transmembrane transport
D2B33_20730	COG3093	addiction module antidote protein HigA
D2B33_20745	COG0305	Participates in initiation and elongation during chromosome replication
D2B33_20755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D2B33_20785	COG0745	RESPONSE REGULATOR receiver
D2B33_20790	COG5002	protein histidine kinase activity
D2B33_20795	COG4863	YycH protein
D2B33_20800	COG4853	Protein conserved in bacteria
D2B33_20805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D2B33_20810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D2B33_20825	COG0456	acetyltransferase
D2B33_20840	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D2B33_20850	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D2B33_20855	COG2197	response regulator
D2B33_20860	COG4585	Histidine kinase
D2B33_20865	COG0842	Transport permease protein
D2B33_20870	COG1131	(ABC) transporter
D2B33_20885	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_20890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D2B33_20895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_20920	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D2B33_20940	COG1113	amino acid transport
D2B33_20945	COG3634	alkyl hydroperoxide reductase activity
D2B33_20950	COG0450	alkyl hydroperoxide reductase
D2B33_20955	COG1454	alcohol dehydrogenase
D2B33_20955	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_20985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D2B33_20995	COG1940	carbohydrate kinase activity
D2B33_21000	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D2B33_21005	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_21010	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D2B33_21015	COG1609	Transcriptional regulator
D2B33_21020	COG2182	Extracellular solute-binding protein
D2B33_21025	COG1175	transmembrane transport
D2B33_21030	COG3833	ABC-type maltose transport systems, permease component
D2B33_21035	COG1874	Beta-galactosidase
D2B33_21040	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D2B33_21045	COG0686	Belongs to the AlaDH PNT family
D2B33_21050	COG1115	amino acid carrier protein
D2B33_21055	COG0840	transmembrane signaling receptor activity
D2B33_21055	COG5278	phosphoserine phosphatase activity
D2B33_21065	COG0745	RESPONSE REGULATOR receiver
D2B33_21070	COG2205	protein histidine kinase activity
D2B33_21075	COG1136	(ABC) transporter
D2B33_21080	COG0577	efflux transmembrane transporter activity
D2B33_21085	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D2B33_21115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D2B33_21135	COG0561	phosphatase activity
D2B33_21140	COG0488	(ABC) transporter
D2B33_21145	COG0326	Molecular chaperone. Has ATPase activity
D2B33_21150	COG2271	Major facilitator Superfamily
D2B33_21155	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_21160	COG0667	Aldo Keto reductase
D2B33_21165	COG1349	DNA-binding transcription factor activity
D2B33_21170	COG1012	belongs to the aldehyde dehydrogenase family
D2B33_21175	COG3718	enzyme involved in inositol metabolism
D2B33_21180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_21185	COG3962	Belongs to the TPP enzyme family
D2B33_21190	COG1082	Xylose isomerase domain protein TIM barrel
D2B33_21195	COG2814	Major facilitator Superfamily
D2B33_21200	COG0673	inositol 2-dehydrogenase activity
D2B33_21205	COG1082	Xylose isomerase domain protein TIM barrel
D2B33_21210	COG1082	Xylose isomerase domain protein TIM barrel
D2B33_21215	COG0191	fructose-bisphosphate aldolase activity
D2B33_21225	COG1181	Belongs to the D-alanine--D-alanine ligase family
D2B33_21240	COG3977	Valine--pyruvate aminotransferase
D2B33_21250	COG1215	transferase activity, transferring glycosyl groups
D2B33_21255	COG5298	Protein conserved in bacteria
D2B33_21260	COG3706	GGDEF domain
D2B33_21265	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D2B33_21270	COG2390	Transcriptional regulator
D2B33_21275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D2B33_21280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D2B33_21285	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D2B33_21330	COG0513	Belongs to the DEAD box helicase family
D2B33_21335	COG3507	Belongs to the glycosyl hydrolase 43 family
D2B33_21340	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D2B33_21350	COG1263	PTS System
D2B33_21350	COG2190	(PTS) system
D2B33_21350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_21355	COG2723	6-phospho-beta-galactosidase activity
D2B33_21360	COG0745	RESPONSE REGULATOR receiver
D2B33_21365	COG2205	protein histidine kinase activity
D2B33_21370	COG1136	(ABC) transporter
D2B33_21375	COG0577	efflux transmembrane transporter activity
D2B33_21380	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D2B33_21390	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D2B33_21395	COG2224	Isocitrate lyase
D2B33_21400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D2B33_21405	COG4721	ABC-type cobalt transport system, permease component
D2B33_21410	COG1122	ATPase activity
D2B33_21415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D2B33_21420	COG3711	transcriptional antiterminator
D2B33_21425	COG2190	(PTS) system
D2B33_21425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_21425	COG1263	PTS System
D2B33_21430	COG2723	6-phospho-beta-galactosidase activity
D2B33_21440	COG0693	protein deglycase activity
D2B33_21440	COG0753	catalase activity
D2B33_21465	COG2233	PERMEase
D2B33_21470	COG2363	Small membrane protein
D2B33_21485	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D2B33_21490	COG1216	Glycosyl transferase, family 2
D2B33_21495	COG0351	phosphomethylpyrimidine kinase
D2B33_21505	COG1621	beta-fructofuranosidase activity
D2B33_21510	COG1263	PTS System
D2B33_21510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D2B33_21515	COG3711	transcriptional antiterminator
D2B33_21525	COG1404	Belongs to the peptidase S8 family
D2B33_21535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D2B33_21540	COG0778	Nitroreductase
D2B33_21545	COG1473	amidohydrolase
D2B33_21550	COG0772	Belongs to the SEDS family
D2B33_21555	COG0772	Belongs to the SEDS family
D2B33_21575	COG0456	acetyltransferase
D2B33_21615	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D2B33_21625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D2B33_21630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D2B33_21635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_21650	COG0655	NAD(P)H dehydrogenase (quinone) activity
D2B33_21655	COG3162	membrane
D2B33_21660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_21665	COG1070	Carbohydrate kinase
D2B33_21670	COG2115	Belongs to the xylose isomerase family
D2B33_21675	COG1940	carbohydrate kinase activity
D2B33_21680	COG0352	thiamine-phosphate diphosphorylase activity
D2B33_21685	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D2B33_21690	COG0583	DNA-binding transcription factor activity
D2B33_21705	COG1380	Effector of murein hydrolase LrgA
D2B33_21710	COG1346	cytolysis
D2B33_21720	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D2B33_21725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D2B33_21730	COG0346	lactoylglutathione lyase activity
D2B33_21735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D2B33_21740	COG1442	glycosyl transferase family 8
D2B33_21755	COG4585	Histidine kinase
D2B33_21760	COG2197	response regulator
D2B33_21765	COG2409	Drug exporters of the RND superfamily
D2B33_21770	COG5522	Integral membrane protein (intg_mem_TP0381)
D2B33_21775	COG2271	Major facilitator Superfamily
D2B33_21780	COG4948	Mandelate Racemase Muconate Lactonizing
D2B33_21785	COG0800	Aldolase
D2B33_21790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D2B33_21800	COG2234	aminopeptidase activity
D2B33_21805	COG0477	Major facilitator Superfamily
D2B33_21820	COG2357	RelA SpoT domain protein
D2B33_21835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D2B33_21840	COG1696	Membrane protein involved in D-alanine export
D2B33_21845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D2B33_21850	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D2B33_21855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D2B33_21860	COG2814	Major facilitator Superfamily
D2B33_21865	COG1486	melibiose metabolic process
D2B33_21870	COG1447	Phosphotransferase system cellobiose-specific component IIA
D2B33_21875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_21880	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_21885	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D2B33_21885	COG3711	transcriptional antiterminator
D2B33_21890	COG2094	Belongs to the DNA glycosylase MPG family
D2B33_21900	COG0372	Belongs to the citrate synthase family
D2B33_21905	COG2079	MmgE PrpD family protein
D2B33_21910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D2B33_21925	COG1132	(ABC) transporter
D2B33_21930	COG2755	lipolytic protein G-D-S-L family
D2B33_21945	COG2814	Major facilitator Superfamily
D2B33_21950	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D2B33_21955	COG1131	(ABC) transporter
D2B33_21975	COG1595	DNA-templated transcription, initiation
D2B33_21980	COG2814	Major facilitator Superfamily
D2B33_21990	COG0753	catalase activity
D2B33_21995	COG0753	catalase activity
D2B33_22000	COG0735	belongs to the Fur family
D2B33_22010	COG3866	Pectate lyase
D2B33_22015	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D2B33_22020	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D2B33_22025	COG4988	ABC transporter
D2B33_22030	COG1294	oxidase, subunit
D2B33_22035	COG1271	oxidase subunit
D2B33_22045	COG2116	formate transmembrane transporter activity
D2B33_22055	COG0281	malic enzyme
D2B33_22060	COG1757	Na H antiporter
D2B33_22065	COG1027	Aspartate ammonia-lyase
D2B33_22070	COG0252	asparaginase activity
D2B33_22075	COG1396	sequence-specific DNA binding
D2B33_22080	COG2706	6-phosphogluconolactonase activity
D2B33_22085	COG0745	RESPONSE REGULATOR receiver
D2B33_22090	COG2205	protein histidine kinase activity
D2B33_22095	COG1136	(ABC) transporter
D2B33_22100	COG0577	efflux transmembrane transporter activity
D2B33_22105	COG5294	Protein conserved in bacteria
D2B33_22120	COG0726	polysaccharide deacetylase
D2B33_22125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D2B33_22135	COG1215	transferase activity, transferring glycosyl groups
D2B33_22140	COG3493	citrate carrier protein
D2B33_22145	COG0584	glycerophosphoryl diester phosphodiesterase
D2B33_22160	COG1368	sulfuric ester hydrolase activity
D2B33_22170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D2B33_22190	COG2235	arginine
D2B33_22195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D2B33_22205	COG0549	Belongs to the carbamate kinase family
D2B33_22215	COG2723	6-phospho-beta-galactosidase activity
D2B33_22220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D2B33_22230	COG1595	DNA-templated transcription, initiation
D2B33_22240	COG2195	Cleaves the N-terminal amino acid of tripeptides
D2B33_22255	COG2223	nitrite transmembrane transporter activity
D2B33_22260	COG0395	ABC-type sugar transport system, permease component
D2B33_22265	COG1175	transmembrane transport
D2B33_22275	COG1609	Transcriptional regulator
D2B33_22290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D2B33_22295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D2B33_22300	COG0463	Glycosyl transferase, family 2
D2B33_22305	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D2B33_22345	COG1131	(ABC) transporter
D2B33_22365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D2B33_22385	COG0280	phosphate acetyltransferase
D2B33_22395	COG1414	Transcriptional regulator
D2B33_22420	COG2814	Major facilitator Superfamily
D2B33_22445	COG4844	belongs to the
D2B33_22450	COG1078	dGTPase activity
D2B33_22455	COG3465	dGTPase activity
D2B33_22465	COG1942	4-Oxalocrotonate Tautomerase
D2B33_22470	COG1994	Peptidase M50
D2B33_22480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D2B33_22485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D2B33_22490	COG0010	Belongs to the arginase family
D2B33_22495	COG4506	Protein conserved in bacteria
D2B33_22500	COG0018	arginyl-trna synthetase
D2B33_22510	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D2B33_22515	COG2181	nitrate reductase activity
D2B33_22515	COG0247	lactate metabolic process
D2B33_22520	COG0183	Belongs to the thiolase family
D2B33_22525	COG1250	3-hydroxyacyl-CoA dehydrogenase
D2B33_22530	COG1960	acyl-CoA dehydrogenase activity
D2B33_22535	COG1960	acyl-CoA dehydrogenase activity
D2B33_22540	COG3343	RNA polymerase activity
D2B33_22545	COG0504	CTP synthase activity
D2B33_22550	COG4821	SIS domain
D2B33_22555	COG2204	response regulator
D2B33_22560	COG0191	fructose-bisphosphate aldolase activity
D2B33_22565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D2B33_22570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D2B33_22575	COG1494	fructose-1,6-bisphosphatase
D2B33_22580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D2B33_22585	COG0254	rRNA binding
D2B33_22590	COG1435	thymidine kinase activity
D2B33_22595	COG0281	malic enzyme
D2B33_22600	COG0679	Auxin Efflux Carrier
D2B33_22605	COG0789	Transcriptional regulator
D2B33_22610	COG0346	lactoylglutathione lyase activity
D2B33_22615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D2B33_22620	COG2890	protein-(glutamine-N5) methyltransferase activity
D2B33_22630	COG1609	Transcriptional regulator
D2B33_22635	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D2B33_22640	COG0561	phosphatase activity
D2B33_22645	COG0673	inositol 2-dehydrogenase activity
D2B33_22650	COG0738	Major facilitator superfamily