locus-tag	class	description
KY997_00015	COG1131	(ABC) transporter
KY997_00020	COG0842	Transport permease protein
KY997_00030	COG2197	response regulator
KY997_00065	COG0456	acetyltransferase
KY997_00085	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KY997_00090	COG4853	Protein conserved in bacteria
KY997_00095	COG4863	YycH protein
KY997_00100	COG5002	protein histidine kinase activity
KY997_00130	COG1051	belongs to the nudix hydrolase family
KY997_00145	COG0305	Participates in initiation and elongation during chromosome replication
KY997_00160	COG3093	addiction module antidote protein HigA
KY997_00165	COG2807	transmembrane transport
KY997_00170	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KY997_00180	COG2188	Transcriptional regulator
KY997_00185	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KY997_00190	COG1263	PTS System
KY997_00190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_00195	COG0359	binds to the 23S rRNA
KY997_00200	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KY997_00205	COG4241	membrane
KY997_00215	COG5577	PFAM Coat F domain
KY997_00220	COG0589	response to stress
KY997_00225	COG0659	secondary active sulfate transmembrane transporter activity
KY997_00230	COG2271	Major facilitator Superfamily
KY997_00235	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KY997_00240	COG0629	single-stranded DNA binding
KY997_00245	COG0360	Binds together with S18 to 16S ribosomal RNA
KY997_00250	COG0012	GTP binding
KY997_00255	COG4481	Protein conserved in bacteria
KY997_00270	COG1475	DNA binding
KY997_00275	COG1192	Involved in chromosome partitioning
KY997_00280	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY997_00285	COG1595	DNA-templated transcription, initiation
KY997_00295	COG0357	Ribosomal RNA small subunit methyltransferase G
KY997_00305	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KY997_00310	COG1847	R3H domain protein
KY997_00315	COG0706	membrane insertase activity
KY997_00330	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KY997_00340	COG2501	S4 domain
KY997_00360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KY997_00395	COG0516	GMP reductase activity
KY997_00395	COG0517	IMP dehydrogenase activity
KY997_00400	COG1686	Belongs to the peptidase S11 family
KY997_00405	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KY997_00410	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KY997_00430	COG3835	regulator
KY997_00445	COG1428	Deoxynucleoside kinase
KY997_00450	COG1428	Deoxynucleoside kinase
KY997_00460	COG1335	isochorismatase
KY997_00465	COG0590	tRNA wobble adenosine to inosine editing
KY997_00475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KY997_00480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KY997_00485	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KY997_00530	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KY997_00545	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KY997_00550	COG3870	Protein conserved in bacteria
KY997_00555	COG1728	Protein conserved in bacteria
KY997_00570	COG4467	Involved in initiation control of chromosome replication
KY997_00575	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KY997_00580	COG2827	Endonuclease containing a URI domain
KY997_00585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KY997_00590	COG2002	toxin-antitoxin pair type II binding
KY997_00600	COG0084	hydrolase, TatD family'
KY997_00605	COG3583	domain protein
KY997_00605	COG3584	3D domain protein
KY997_00610	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KY997_00615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KY997_00625	COG4466	Protein conserved in bacteria
KY997_00635	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KY997_00640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KY997_00645	COG0251	oxidation-reduction process
KY997_00650	COG2088	sporulation resulting in formation of a cellular spore
KY997_00660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KY997_00665	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KY997_00670	COG0193	aminoacyl-tRNA hydrolase activity
KY997_00720	COG1098	S1 RNA binding domain
KY997_00740	COG2304	oxidoreductase activity
KY997_00755	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KY997_00770	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KY997_00775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KY997_00785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KY997_00790	COG0512	Glutamine amidotransferase of anthranilate synthase
KY997_00795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KY997_00800	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KY997_00805	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KY997_00815	COG1396	sequence-specific DNA binding
KY997_00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KY997_00825	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KY997_00905	COG4463	regulation of RNA biosynthetic process
KY997_00915	COG3869	Catalyzes the specific phosphorylation of arginine residues in
KY997_00935	COG4956	integral membrane protein (PIN domain superfamily)
KY997_00940	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KY997_00945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KY997_00950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KY997_00955	COG1045	serine acetyltransferase
KY997_00960	COG0215	cysteine-tRNA ligase activity
KY997_00965	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KY997_00970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KY997_00975	COG3688	RNA-binding protein containing a PIN domain
KY997_01000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KY997_01005	COG0081	regulation of translation
KY997_01010	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KY997_01015	COG0222	ribosome binding
KY997_01020	COG2813	Specifically methylates the guanine in position
KY997_01035	COG1358	cellular component organization or biogenesis
KY997_01040	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
KY997_01045	COG0049	tRNA binding
KY997_01050	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KY997_01055	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KY997_01065	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
KY997_01070	COG0088	Forms part of the polypeptide exit tunnel
KY997_01075	COG0089	rRNA binding
KY997_01085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KY997_01090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KY997_01095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KY997_01100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KY997_01105	COG0255	Belongs to the universal ribosomal protein uL29 family
KY997_01110	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
KY997_01115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
KY997_01120	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
KY997_01125	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
KY997_01130	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KY997_01135	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
KY997_01140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KY997_01145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
KY997_01150	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
KY997_01155	COG1841	ribosomal large subunit assembly
KY997_01160	COG0200	Binds to the 23S rRNA
KY997_01170	COG0563	adenylate kinase activity
KY997_01175	COG0024	Methionine aminopeptidase
KY997_01185	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KY997_01190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KY997_01195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KY997_01200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KY997_01205	COG0202	RNA polymerase activity
KY997_01210	COG0203	ribosomal protein L17
KY997_01215	COG1122	ATPase activity
KY997_01220	COG1122	ATPase activity
KY997_01225	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KY997_01230	COG0101	tRNA pseudouridine synthase activity
KY997_01235	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KY997_01240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KY997_01265	COG2318	DinB family
KY997_01285	COG1131	(ABC) transporter
KY997_01370	COG3290	protein histidine kinase activity
KY997_01395	COG0860	N-Acetylmuramoyl-L-alanine amidase
KY997_01400	COG0489	protein tyrosine kinase activity
KY997_01410	COG2194	sulfuric ester hydrolase activity
KY997_01455	COG0385	Bile acid
KY997_01470	COG3876	Protein conserved in bacteria
KY997_01475	COG1472	Belongs to the glycosyl hydrolase 3 family
KY997_01485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_01485	COG1263	PTS System
KY997_01490	COG1737	Transcriptional regulator
KY997_01495	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
KY997_01540	COG5662	AntiSigma factor
KY997_01550	COG4856	YbbR-like protein
KY997_01555	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY997_01560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KY997_01575	COG1131	(ABC) transporter
KY997_01580	COG1725	Transcriptional regulator
KY997_01590	COG0789	Transcriptional regulator
KY997_01600	COG0640	Transcriptional regulator
KY997_01615	COG1132	(ABC) transporter
KY997_01670	COG2211	Major facilitator Superfamily
KY997_01695	COG1331	Highly conserved protein containing a thioredoxin domain
KY997_01700	COG2226	methyltransferase
KY997_01715	COG1802	Transcriptional regulator
KY997_01720	COG0730	response to heat
KY997_01740	COG1283	sodium-dependent phosphate transmembrane transporter activity
KY997_01755	COG3409	Peptidoglycan-binding domain 1 protein
KY997_01765	COG0697	spore germination
KY997_01780	COG2197	response regulator
KY997_01800	COG0371	Dehydrogenase
KY997_01815	COG4257	antibiotic catabolic process
KY997_01825	COG0833	amino acid
KY997_01830	COG2040	homocysteine
KY997_01855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KY997_01855	COG4451	ribulose bisphosphate carboxylase, small
KY997_01860	COG2205	protein histidine kinase activity
KY997_01865	COG1115	amino acid carrier protein
KY997_01870	COG2066	Belongs to the glutaminase family
KY997_01880	COG0784	Response regulator, receiver
KY997_01905	COG3540	Alkaline phosphatase
KY997_01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KY997_01915	COG0805	protein transport
KY997_01920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY997_01925	COG1012	belongs to the aldehyde dehydrogenase family
KY997_01930	COG2271	Major facilitator Superfamily
KY997_01940	COG2186	Transcriptional regulator
KY997_01965	COG0745	RESPONSE REGULATOR receiver
KY997_01970	COG2205	protein histidine kinase activity
KY997_01975	COG1131	(ABC) transporter
KY997_02005	COG1846	Transcriptional regulator
KY997_02010	COG0318	PFAM AMP-dependent synthetase and ligase
KY997_02030	COG0789	Transcriptional regulator
KY997_02055	COG0697	spore germination
KY997_02070	COG1131	(ABC) transporter
KY997_02100	COG1942	4-Oxalocrotonate Tautomerase
KY997_02135	COG0456	acetyltransferase
KY997_02145	COG1164	Oligoendopeptidase f
KY997_02150	COG2261	transglycosylase associated protein
KY997_02170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_02175	COG1447	Phosphotransferase system cellobiose-specific component IIA
KY997_02180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_02185	COG1486	melibiose metabolic process
KY997_02190	COG2188	Transcriptional regulator
KY997_02195	COG3394	polysaccharide catabolic process
KY997_02210	COG3591	Belongs to the peptidase S1B family
KY997_02235	COG3773	Cell wall hydrolase
KY997_02245	COG3883	PFAM NLP P60 protein
KY997_02245	COG0791	NLP P60 protein
KY997_02255	COG1131	(ABC) transporter
KY997_02260	COG1309	transcriptional regulator
KY997_02280	COG2310	stress, protein
KY997_02285	COG2310	stress, protein
KY997_02290	COG2310	stress, protein
KY997_02295	COG0861	Integral membrane protein TerC family
KY997_02315	COG3853	Toxic anion resistance protein (TelA)
KY997_02320	COG0785	Cytochrome C biogenesis protein
KY997_02340	COG1620	l-lactate permease
KY997_02345	COG1280	lysine exporter protein (LysE YggA)
KY997_02355	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KY997_02365	COG3541	Predicted nucleotidyltransferase
KY997_02375	COG1012	belongs to the aldehyde dehydrogenase family
KY997_02385	COG2508	Transcriptional regulator
KY997_02390	COG3689	TIGRFAM TIGR03943 family protein
KY997_02425	COG0765	amino acid transport
KY997_02430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY997_02440	COG1116	anion transmembrane transporter activity
KY997_02445	COG2723	6-phospho-beta-galactosidase activity
KY997_02455	COG3209	COG3209 Rhs family protein
KY997_02470	COG5444	nuclease activity
KY997_02520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KY997_02525	COG0697	spore germination
KY997_02530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY997_02540	COG2819	hydrolase of the alpha beta superfamily
KY997_02545	COG3708	Transcriptional regulator
KY997_02545	COG2207	Transcriptional regulator
KY997_02575	COG0765	amino acid transport
KY997_02580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KY997_02585	COG3829	transcription factor binding
KY997_02590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KY997_02600	COG0010	Belongs to the arginase family
KY997_02605	COG0583	DNA-binding transcription factor activity
KY997_02610	COG0163	prenyltransferase activity
KY997_02615	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KY997_02705	COG4214	carbohydrate transport
KY997_02710	COG2271	Major facilitator Superfamily
KY997_02715	COG1846	Transcriptional regulator
KY997_02715	COG0456	acetyltransferase
KY997_02730	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
KY997_02740	COG3104	oligopeptide transport
KY997_02745	COG5434	Belongs to the glycosyl hydrolase 28 family
KY997_02760	COG0697	spore germination
KY997_02770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KY997_02775	COG0789	Transcriptional regulator
KY997_02780	COG1136	(ABC) transporter
KY997_02785	COG0577	efflux transmembrane transporter activity
KY997_02790	COG0745	RESPONSE REGULATOR receiver
KY997_02800	COG0840	transmembrane signaling receptor activity
KY997_02805	COG0527	aspartate kinase activity
KY997_02815	COG4605	iron ion homeostasis
KY997_02825	COG4607	ABC-type enterochelin transport system periplasmic component
KY997_02830	COG2814	Major facilitator Superfamily
KY997_02835	COG1309	transcriptional regulator
KY997_02845	COG0778	Nitroreductase
KY997_02850	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KY997_02855	COG0640	Transcriptional regulator
KY997_02865	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KY997_02875	COG1012	belongs to the aldehyde dehydrogenase family
KY997_02890	COG4549	nuclear export factor GLE1
KY997_02895	COG1276	copper resistance
KY997_02895	COG2372	response to copper ion
KY997_02915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY997_02920	COG2146	nitrite reductase [NAD(P)H] activity
KY997_02925	COG1587	Uroporphyrinogen-III synthase
KY997_02925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KY997_02930	COG1802	Transcriptional regulator
KY997_02950	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_02970	COG3958	Transketolase
KY997_02975	COG0561	phosphatase activity
KY997_02980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KY997_02995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KY997_03005	COG1414	Transcriptional regulator
KY997_03010	COG2755	lipolytic protein G-D-S-L family
KY997_03020	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_03025	COG0246	Mannitol dehydrogenase
KY997_03035	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_03040	COG1917	Cupin 2, conserved barrel domain protein
KY997_03050	COG3871	stress protein (general stress protein 26)
KY997_03065	COG2814	Major facilitator Superfamily
KY997_03075	COG1522	sequence-specific DNA binding
KY997_03085	COG0287	Prephenate dehydrogenase
KY997_03090	COG0512	Glutamine amidotransferase of anthranilate synthase
KY997_03090	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KY997_03095	COG1605	Chorismate mutase
KY997_03115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY997_03120	COG1914	H( )-stimulated, divalent metal cation uptake system
KY997_03125	COG2261	transglycosylase associated protein
KY997_03135	COG1819	glycosyl
KY997_03140	COG4876	unkown
KY997_03155	COG0662	Cupin 2, conserved barrel domain protein
KY997_03165	COG0628	permease
KY997_03175	COG1131	(ABC) transporter
KY997_03180	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KY997_03205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_03210	COG1181	Belongs to the D-alanine--D-alanine ligase family
KY997_03215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KY997_03230	COG3402	PFAM membrane-flanked domain
KY997_03245	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KY997_03250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KY997_03255	COG0864	Transcriptional regulator
KY997_03260	COG2337	Toxic component of a toxin-antitoxin (TA) module
KY997_03265	COG1366	Belongs to the anti-sigma-factor antagonist family
KY997_03270	COG1366	Belongs to the anti-sigma-factor antagonist family
KY997_03280	COG2208	phosphoserine phosphatase activity
KY997_03295	COG1191	sigma factor activity
KY997_03300	COG2208	phosphoserine phosphatase activity
KY997_03305	COG2183	response to ionizing radiation
KY997_03330	COG3091	SprT-like family
KY997_03370	COG0582	viral genome integration into host DNA
KY997_03400	COG0726	polysaccharide deacetylase
KY997_03405	COG3239	Fatty acid desaturase
KY997_03410	COG1278	Cold shock
KY997_03435	COG2364	Membrane
KY997_03440	COG1846	Transcriptional regulator
KY997_03450	COG2808	Putative FMN-binding domain
KY997_03460	COG1733	regulation of RNA biosynthetic process
KY997_03465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_03495	COG1733	regulation of RNA biosynthetic process
KY997_03505	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KY997_03510	COG1113	amino acid transport
KY997_03525	COG0596	Alpha beta hydrolase
KY997_03530	COG5566	PFAM Mor transcription activator
KY997_03535	COG1595	DNA-templated transcription, initiation
KY997_03545	COG2755	lipolytic protein G-D-S-L family
KY997_03545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KY997_03550	COG0494	nUDIX hydrolase
KY997_03560	COG1979	alcohol dehydrogenase
KY997_03570	COG3279	Response regulator of the LytR AlgR family
KY997_03580	COG3764	Sortase (surface protein transpeptidase)
KY997_03585	COG2814	Major facilitator Superfamily
KY997_03630	COG0802	atpase or kinase
KY997_03635	COG1214	PFAM Peptidase M22, glycoprotease
KY997_03655	COG0315	cyclic pyranopterin monophosphate synthase activity
KY997_03665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KY997_03680	COG1266	CAAX protease self-immunity
KY997_03685	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KY997_03690	COG0459	protein refolding
KY997_03720	COG2135	peptidase activity
KY997_03735	COG3848	Pyruvate phosphate dikinase
KY997_03735	COG0574	Belongs to the PEP-utilizing enzyme family
KY997_03750	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KY997_03760	COG2814	Major facilitator Superfamily
KY997_03765	COG1842	Phage shock protein A
KY997_03775	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KY997_03790	COG1378	Sugar-specific transcriptional regulator TrmB
KY997_03795	COG1280	lysine exporter protein (LysE YggA)
KY997_03800	COG3339	Conserved Protein
KY997_03805	COG0772	Belongs to the SEDS family
KY997_03855	COG0366	Alpha amylase catalytic
KY997_03860	COG2182	Extracellular solute-binding protein
KY997_03865	COG1175	transmembrane transport
KY997_03875	COG5521	maltodextrose utilization protein MalA
KY997_03885	COG0366	Alpha amylase catalytic
KY997_03890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KY997_03895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KY997_03900	COG1846	Transcriptional regulator
KY997_03920	COG0823	Involved in the tonB-independent uptake of proteins
KY997_03950	COG0702	epimerase
KY997_03980	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KY997_03985	COG0714	Associated with various cellular activities
KY997_03990	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KY997_03995	COG1305	Transglutaminase-like
KY997_04000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KY997_04000	COG0519	Catalyzes the synthesis of GMP from XMP
KY997_04010	COG2252	PERMEase
KY997_04025	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
KY997_04040	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KY997_04045	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KY997_04055	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KY997_04070	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KY997_04075	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KY997_04080	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KY997_04085	COG0138	bifunctional purine biosynthesis protein purh
KY997_04090	COG0151	Belongs to the GarS family
KY997_04125	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KY997_04130	COG1470	cell adhesion involved in biofilm formation
KY997_04135	COG4496	protein, YerC YecD
KY997_04140	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
KY997_04145	COG0210	DNA helicase
KY997_04155	COG4851	CamS sex pheromone cAM373 precursor
KY997_04180	COG1735	metal-dependent hydrolase with the TIM-barrel fold
KY997_04190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KY997_04195	COG3457	Alanine racemase
KY997_04200	COG0363	glucosamine-6-phosphate deaminase activity
KY997_04205	COG1285	pathogenesis
KY997_04210	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY997_04215	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KY997_04220	COG0154	amidase activity
KY997_04225	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KY997_04240	COG4124	Belongs to the glycosyl hydrolase 26 family
KY997_04245	COG1309	transcriptional regulator
KY997_04260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY997_04265	COG1957	nucleoside hydrolase
KY997_04275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KY997_04310	COG3711	transcriptional antiterminator
KY997_04315	COG0457	Tetratricopeptide repeat
KY997_04335	COG3586	endonuclease activity
KY997_04340	COG0697	spore germination
KY997_04345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY997_04355	COG0217	transcriptional regulatory protein
KY997_04390	COG0840	transmembrane signaling receptor activity
KY997_04395	COG0109	protoheme IX farnesyltransferase activity
KY997_04400	COG1309	transcriptional regulator
KY997_04410	COG0488	(ABC) transporter
KY997_04425	COG0640	Transcriptional regulator
KY997_04430	COG1469	GTP cyclohydrolase I activity
KY997_04445	COG0523	cobalamin synthesis protein
KY997_04455	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KY997_04460	COG0156	8-amino-7-oxononanoate synthase activity
KY997_04465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
KY997_04475	COG2124	cytochrome p450
KY997_04485	COG0789	Transcriptional regulator
KY997_04490	COG2814	Major facilitator Superfamily
KY997_04520	COG0471	metal ion transport
KY997_04530	COG1136	(ABC) transporter
KY997_04560	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KY997_04565	COG3858	chitin binding
KY997_04570	COG5658	integral membrane protein
KY997_04575	COG0640	Transcriptional regulator
KY997_04580	COG1254	Belongs to the acylphosphatase family
KY997_04585	COG2258	MOSC domain
KY997_04600	COG0024	Methionine aminopeptidase
KY997_04620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_04620	COG1263	PTS System
KY997_04630	COG2188	Transcriptional regulator
KY997_04655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KY997_04660	COG1045	serine acetyltransferase
KY997_04680	COG0457	Tetratricopeptide repeat
KY997_04680	COG0463	Glycosyl transferase, family 2
KY997_04690	COG0673	inositol 2-dehydrogenase activity
KY997_04705	COG1733	regulation of RNA biosynthetic process
KY997_04710	COG0778	Nitroreductase
KY997_04720	COG0693	protein deglycase activity
KY997_04725	COG4840	Belongs to the UPF0435 family
KY997_04730	COG1115	amino acid carrier protein
KY997_04735	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KY997_04740	COG4980	gas vesicle protein
KY997_04745	COG1295	ribonuclease BN
KY997_04760	COG0387	Pfam Sodium calcium exchanger
KY997_04785	COG0371	Dehydrogenase
KY997_04795	COG0598	Magnesium transport protein CorA
KY997_04830	COG1819	glycosyl
KY997_04840	COG0477	Major facilitator Superfamily
KY997_04850	COG1263	PTS System
KY997_04850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_04855	COG3711	transcriptional antiterminator
KY997_04860	COG0288	reversible hydration of carbon dioxide
KY997_04870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KY997_04875	COG5609	conserved protein (DUF2294)
KY997_04890	COG0022	dehydrogenase e1 component
KY997_04895	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY997_04910	COG1742	UPF0060 membrane protein
KY997_04915	COG1486	melibiose metabolic process
KY997_04920	COG1737	Transcriptional regulator
KY997_04925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_04925	COG1263	PTS System
KY997_04940	COG1733	regulation of RNA biosynthetic process
KY997_04945	COG2259	Doxx family
KY997_04950	COG2514	catechol 2,3-dioxygenase activity
KY997_04960	COG3507	Belongs to the glycosyl hydrolase 43 family
KY997_04970	COG1653	transport
KY997_04975	COG2249	NAD(P)H dehydrogenase (quinone) activity
KY997_04980	COG1051	belongs to the nudix hydrolase family
KY997_05000	COG0384	phenazine biosynthesis protein PhzF
KY997_05005	COG0778	Nitroreductase
KY997_05025	COG1090	epimerase
KY997_05030	COG2137	regulation of response to DNA damage stimulus
KY997_05055	COG0463	Glycosyl transferase, family 2
KY997_05065	COG4485	Bacterial membrane protein, YfhO
KY997_05075	COG1194	a g-specific adenine glycosylase
KY997_05085	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_05100	COG3557	Belongs to the UPF0374 family
KY997_05105	COG1132	(ABC) transporter
KY997_05110	COG0444	Belongs to the ABC transporter superfamily
KY997_05115	COG4608	Belongs to the ABC transporter superfamily
KY997_05120	COG0747	negative chemotaxis
KY997_05135	COG4129	membrane
KY997_05140	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KY997_05145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KY997_05150	COG0735	belongs to the Fur family
KY997_05255	COG4974	Belongs to the 'phage' integrase family
KY997_05390	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY997_05390	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY997_05410	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KY997_05430	COG1780	Probably involved in ribonucleotide reductase function
KY997_05435	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY997_05450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY997_05465	COG3584	3D domain protein
KY997_05515	COG1793	dna ligase
KY997_05840	COG0582	viral genome integration into host DNA
KY997_05870	COG1802	Transcriptional regulator
KY997_05870	COG4626	Terminase
KY997_05930	COG3953	SLT domain
KY997_05930	COG5280	Phage tail tape measure protein TP901
KY997_05940	COG1705	Flagellar rod assembly protein muramidase FlgJ
KY997_05945	COG5434	Belongs to the glycosyl hydrolase 28 family
KY997_06020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
KY997_06060	COG1116	anion transmembrane transporter activity
KY997_06065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KY997_06070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY997_06075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY997_06085	COG1476	TRANSCRIPTIONal
KY997_06115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KY997_06125	COG3382	B3 4 domain protein
KY997_06130	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KY997_06140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KY997_06150	COG1664	Polymer-forming cytoskeletal
KY997_06165	COG2718	Belongs to the UPF0229 family
KY997_06170	COG1566	PFAM secretion protein HlyD family protein
KY997_06175	COG2814	Major facilitator Superfamily
KY997_06180	COG0655	NAD(P)H dehydrogenase (quinone) activity
KY997_06195	COG1725	Transcriptional regulator
KY997_06205	COG1131	(ABC) transporter
KY997_06215	COG1278	Cold shock
KY997_06225	COG2011	ABC-type metal ion transport system permease component
KY997_06235	COG1823	symporter activity
KY997_06260	COG5577	PFAM Coat F domain
KY997_06265	COG5002	protein histidine kinase activity
KY997_06275	COG3764	Sortase (surface protein transpeptidase)
KY997_06300	COG0517	IMP dehydrogenase activity
KY997_06320	COG2116	formate transmembrane transporter activity
KY997_06335	COG0604	alcohol dehydrogenase
KY997_06345	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KY997_06350	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
KY997_06355	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KY997_06360	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KY997_06375	COG4585	Histidine kinase
KY997_06375	COG2203	Gaf domain
KY997_06400	COG1959	2 iron, 2 sulfur cluster binding
KY997_06405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KY997_06405	COG1017	nitric oxide dioxygenase activity
KY997_06415	COG0791	NLP P60 protein
KY997_06415	COG1388	LysM domain
KY997_06420	COG0583	DNA-binding transcription factor activity
KY997_06435	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_06490	COG1595	DNA-templated transcription, initiation
KY997_06495	COG0662	Cupin 2, conserved barrel domain protein
KY997_06500	COG0667	Aldo Keto reductase
KY997_06505	COG0204	Acyl-transferase
KY997_06510	COG3152	Membrane
KY997_06530	COG0789	Transcriptional regulator
KY997_06535	COG1253	flavin adenine dinucleotide binding
KY997_06555	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY997_06560	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KY997_06565	COG0584	glycerophosphoryl diester phosphodiesterase
KY997_06575	COG0668	transmembrane transport
KY997_06605	COG1757	Na H antiporter
KY997_06610	COG2017	converts alpha-aldose to the beta-anomer
KY997_06635	COG0589	response to stress
KY997_06650	COG0702	epimerase
KY997_06675	COG2508	Transcriptional regulator
KY997_06685	COG0189	ligase activity
KY997_06690	COG0189	ligase activity
KY997_06700	COG3679	Belongs to the UPF0342 family
KY997_06710	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KY997_06715	COG1024	Enoyl-CoA hydratase
KY997_06720	COG0457	Tetratricopeptide repeat
KY997_06740	COG4152	abc transporter atp-binding protein
KY997_06745	COG1668	transmembrane transport
KY997_06760	COG3481	metal-dependent phosphohydrolase, HD sub domain
KY997_06770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KY997_06805	COG4980	gas vesicle protein
KY997_06825	COG0537	adenosine 5'-monophosphoramidase activity
KY997_06830	COG1131	(ABC) transporter
KY997_06845	COG1473	amidohydrolase
KY997_06855	COG2329	Antibiotic biosynthesis monooxygenase
KY997_06865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KY997_06870	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KY997_06875	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KY997_06885	COG1511	domain protein
KY997_06890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY997_06905	COG1301	dicarboxylic acid transport
KY997_06915	COG1234	tRNA 3'-trailer cleavage
KY997_06920	COG0095	Lipoate-protein ligase
KY997_06935	COG1396	sequence-specific DNA binding
KY997_06960	COG0697	spore germination
KY997_06970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_06975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_06980	COG0406	alpha-ribazole phosphatase activity
KY997_06985	COG0183	Belongs to the thiolase family
KY997_06990	COG0318	PFAM AMP-dependent synthetase and ligase
KY997_07010	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_07020	COG4903	ComK protein
KY997_07030	COG0398	Pfam SNARE associated Golgi protein
KY997_07035	COG0681	Belongs to the peptidase S26 family
KY997_07055	COG2508	Transcriptional regulator
KY997_07065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KY997_07070	COG3257	ureidoglycine aminohydrolase activity
KY997_07090	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KY997_07105	COG2814	Major facilitator Superfamily
KY997_07140	COG0395	ABC-type sugar transport system, permease component
KY997_07145	COG1486	melibiose metabolic process
KY997_07165	COG3546	catalase activity
KY997_07175	COG2814	Major facilitator Superfamily
KY997_07175	COG0477	Major facilitator Superfamily
KY997_07180	COG4533	DNA binding
KY997_07185	COG4533	DNA binding
KY997_07195	COG5002	protein histidine kinase activity
KY997_07200	COG0745	RESPONSE REGULATOR receiver
KY997_07205	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KY997_07215	COG4149	molybdate abc transporter
KY997_07230	COG0420	3'-5' exonuclease activity
KY997_07235	COG0420	3'-5' exonuclease activity
KY997_07295	COG0179	Fumarylacetoacetate (FAA) hydrolase
KY997_07325	COG0347	Belongs to the P(II) protein family
KY997_07330	COG0534	Mate efflux family protein
KY997_07335	COG2207	Transcriptional regulator
KY997_07335	COG1917	Cupin 2, conserved barrel domain protein
KY997_07350	COG0673	inositol 2-dehydrogenase activity
KY997_07375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KY997_07385	COG0076	glutamate decarboxylase activity
KY997_07410	COG2153	protein acetylation
KY997_07420	COG2378	regulation of single-species biofilm formation
KY997_07440	COG2996	Protein conserved in bacteria
KY997_07460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_07470	COG0516	GMP reductase activity
KY997_07485	COG0561	phosphatase activity
KY997_07490	COG1073	alpha beta
KY997_07495	COG2151	metal-sulfur cluster biosynthetic enzyme
KY997_07500	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KY997_07505	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KY997_07520	COG0505	Belongs to the CarA family
KY997_07530	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KY997_07535	COG1968	undecaprenyl-diphosphatase activity
KY997_07550	COG2267	carboxylic ester hydrolase activity
KY997_07575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KY997_07580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KY997_07595	COG0444	Belongs to the ABC transporter superfamily
KY997_07600	COG4608	Belongs to the ABC transporter superfamily
KY997_07610	COG0601	transmembrane transport
KY997_07615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY997_07645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY997_07650	COG0444	Belongs to the ABC transporter superfamily
KY997_07655	COG4608	Belongs to the ABC transporter superfamily
KY997_07660	COG0456	acetyltransferase
KY997_07665	COG1393	Belongs to the ArsC family
KY997_07670	COG0861	Integral membrane protein TerC family
KY997_07710	COG4565	transcriptional regulatory protein
KY997_07725	COG1164	Oligoendopeptidase f
KY997_07730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KY997_07735	COG2346	COG2346, Truncated hemoglobins
KY997_07740	COG0741	lytic transglycosylase activity
KY997_07755	COG2357	RelA SpoT domain protein
KY997_07760	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KY997_07770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
KY997_07780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KY997_07785	COG0352	thiamine-phosphate diphosphorylase activity
KY997_07795	COG2104	thiamine diphosphate biosynthetic process
KY997_07800	COG2022	thiamine diphosphate biosynthetic process
KY997_07805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KY997_07810	COG0351	phosphomethylpyrimidine kinase
KY997_07815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KY997_07870	COG0210	DNA helicase
KY997_07880	COG0586	Pfam SNARE associated Golgi protein
KY997_07890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KY997_07895	COG2246	polysaccharide biosynthetic process
KY997_07900	COG2153	protein acetylation
KY997_07905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KY997_07910	COG2382	esterase
KY997_07935	COG0626	cystathionine gamma-synthase activity
KY997_08030	COG0583	DNA-binding transcription factor activity
KY997_08040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KY997_08045	COG0583	DNA-binding transcription factor activity
KY997_08055	COG0346	lactoylglutathione lyase activity
KY997_08075	COG1309	transcriptional regulator
KY997_08090	COG4195	phage-related replication protein
KY997_08095	COG2856	Zn peptidase
KY997_08100	COG1396	sequence-specific DNA binding
KY997_08115	COG1522	sequence-specific DNA binding
KY997_08120	COG1484	DNA-dependent DNA replication
KY997_08140	COG1595	DNA-templated transcription, initiation
KY997_08155	COG5518	Phage portal protein
KY997_08165	COG4653	Phage capsid family
KY997_08220	COG1652	LysM domain
KY997_08225	COG4193	domain, Protein
KY997_08235	COG3628	GPW Gp25 family protein
KY997_08245	COG3778	Protein conserved in bacteria
KY997_08280	COG1802	Transcriptional regulator
KY997_08285	COG1063	alcohol dehydrogenase
KY997_08290	COG1312	Catalyzes the dehydration of D-mannonate
KY997_08295	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_08300	COG1063	alcohol dehydrogenase
KY997_08305	COG2271	Major facilitator Superfamily
KY997_08320	COG0306	phosphate transporter
KY997_08330	COG0405	Gamma-glutamyltransferase
KY997_08335	COG5578	integral membrane protein
KY997_08360	COG0395	ABC-type sugar transport system, permease component
KY997_08365	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
KY997_08375	COG2755	lipolytic protein G-D-S-L family
KY997_08385	COG5578	integral membrane protein
KY997_08400	COG2755	lipolytic protein G-D-S-L family
KY997_08415	COG2755	lipolytic protein G-D-S-L family
KY997_08430	COG1653	transport
KY997_08435	COG4209	transmembrane transport
KY997_08440	COG0395	ABC-type sugar transport system, permease component
KY997_08445	COG0531	amino acid
KY997_08450	COG0346	lactoylglutathione lyase activity
KY997_08460	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KY997_08465	COG2362	D-Aminopeptidase
KY997_08470	COG0601	transmembrane transport
KY997_08475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY997_08480	COG0444	Belongs to the ABC transporter superfamily
KY997_08485	COG4166	transmembrane transport
KY997_08490	COG1619	proteins homologs of microcin C7 resistance protein MccF
KY997_08495	COG4948	Mandelate Racemase Muconate Lactonizing
KY997_08500	COG0791	NLP P60 protein
KY997_08505	COG4608	Belongs to the ABC transporter superfamily
KY997_08515	COG1607	acyl-coa hydrolase
KY997_08545	COG2318	DinB family
KY997_08550	COG2076	Multidrug Resistance protein
KY997_08555	COG2076	Multidrug Resistance protein
KY997_08560	COG0788	formyltetrahydrofolate deformylase activity
KY997_08570	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KY997_08575	COG1764	response to oxidative stress
KY997_08580	COG1846	Transcriptional regulator
KY997_08595	COG0590	tRNA wobble adenosine to inosine editing
KY997_08600	COG0406	alpha-ribazole phosphatase activity
KY997_08620	COG1404	Belongs to the peptidase S8 family
KY997_08630	COG2239	Acts as a magnesium transporter
KY997_08640	COG0789	Transcriptional regulator
KY997_08655	COG1846	Transcriptional regulator
KY997_08680	COG0861	Integral membrane protein TerC family
KY997_08685	COG1191	sigma factor activity
KY997_08705	COG0501	Belongs to the peptidase M48B family
KY997_08710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KY997_08735	COG3594	Acyltransferase
KY997_08775	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KY997_08775	COG0235	Class ii aldolase
KY997_08780	COG0235	Class ii aldolase
KY997_08780	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
KY997_08785	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
KY997_08790	COG0346	lactoylglutathione lyase activity
KY997_08795	COG3339	Conserved Protein
KY997_08805	COG3852	Histidine kinase
KY997_08810	COG1846	Transcriptional regulator
KY997_08815	COG1360	Flagellar Motor Protein
KY997_08820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KY997_08825	COG0542	response to heat
KY997_08830	COG3949	Membrane
KY997_08835	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KY997_08840	COG0720	synthase
KY997_08845	COG0602	queuosine metabolic process
KY997_08850	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
KY997_08855	COG0457	Tetratricopeptide repeat
KY997_08865	COG3739	integral membrane protein
KY997_08870	COG3655	Transcriptional regulator
KY997_08905	COG4873	Protein conserved in bacteria
KY997_08915	COG3773	Cell wall hydrolase
KY997_08925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_08935	COG0006	proline dipeptidase activity
KY997_08945	COG1609	Transcriptional regulator
KY997_08950	COG3711	transcriptional antiterminator
KY997_08955	COG2190	(PTS) system
KY997_08955	COG1263	PTS System
KY997_08955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_08960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_08965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KY997_08980	COG0456	acetyltransferase
KY997_08985	COG0840	transmembrane signaling receptor activity
KY997_08990	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_09005	COG0768	penicillin binding
KY997_09010	COG4191	Histidine kinase
KY997_09025	COG1714	RDD family
KY997_09035	COG0784	Response regulator, receiver
KY997_09035	COG0835	chemotaxis
KY997_09050	COG1376	ErfK ybiS ycfS ynhG family protein
KY997_09055	COG1408	metallophosphoesterase
KY997_09065	COG2200	EAL domain
KY997_09075	COG4703	Protein of unknown function (DUF1797)
KY997_09085	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KY997_09095	COG0517	IMP dehydrogenase activity
KY997_09100	COG0583	DNA-binding transcription factor activity
KY997_09105	COG0716	FMN binding
KY997_09115	COG0716	FMN binding
KY997_09120	COG2171	N-acyltransferase activity
KY997_09125	COG1473	amidohydrolase
KY997_09135	COG0450	alkyl hydroperoxide reductase
KY997_09140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_09155	COG0746	molybdenum cofactor guanylyltransferase activity
KY997_09180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KY997_09205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KY997_09220	COG1349	DNA-binding transcription factor activity
KY997_09230	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY997_09230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY997_09230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_09245	COG0488	(ABC) transporter
KY997_09270	COG2002	toxin-antitoxin pair type II binding
KY997_09275	COG3852	Histidine kinase
KY997_09290	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KY997_09295	COG5503	Protein of unknown function (DUF1447)
KY997_09305	COG0242	peptide deformylase activity
KY997_09325	COG0022	dehydrogenase e1 component
KY997_09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY997_09335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY997_09360	COG4476	Belongs to the UPF0223 family
KY997_09365	COG4493	Belongs to the UPF0637 family
KY997_09375	COG0483	inositol monophosphate 1-phosphatase activity
KY997_09395	COG1595	DNA-templated transcription, initiation
KY997_09410	COG1217	gtp-binding protein TYPA
KY997_09420	COG1846	Transcriptional regulator
KY997_09430	COG4896	Protein conserved in bacteria
KY997_09445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KY997_09450	COG2066	Belongs to the glutaminase family
KY997_09455	COG4838	Belongs to the UPF0358 family
KY997_09460	COG0772	Belongs to the SEDS family
KY997_09470	COG1612	heme a metabolic process
KY997_09475	COG0109	protoheme IX farnesyltransferase activity
KY997_09480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KY997_09480	COG2010	Cytochrome c
KY997_09485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KY997_09490	COG1845	cytochrome c oxidase, subunit III
KY997_09495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KY997_09510	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KY997_09530	COG3679	Belongs to the UPF0342 family
KY997_09535	COG4471	UPF0298 protein
KY997_09550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KY997_09555	COG3314	Sporulation integral membrane protein YlbJ
KY997_09565	COG1323	Belongs to the UPF0348 family
KY997_09570	COG1399	metal-binding, possibly nucleic acid-binding protein
KY997_09585	COG0454	-acetyltransferase
KY997_09600	COG2001	Belongs to the MraZ family
KY997_09605	COG0275	rRNA processing
KY997_09610	COG4839	cell division protein FtsL
KY997_09615	COG0768	penicillin binding
KY997_09625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KY997_09630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KY997_09650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KY997_09655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KY997_09665	COG3879	Bacterial protein of unknown function (DUF881)
KY997_09670	COG3856	small basic protein
KY997_09680	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KY997_09705	COG1191	sigma factor activity
KY997_09710	COG1119	ATPase activity
KY997_09725	COG1873	PFAM PRC-barrel domain
KY997_09730	COG1496	oxidoreductase activity
KY997_09735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KY997_09740	COG1799	cell septum assembly
KY997_09745	COG0762	integral membrane protein
KY997_09755	COG3599	regulation of cell shape
KY997_09765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KY997_09770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KY997_09775	COG0564	pseudouridine synthase activity
KY997_09785	COG2233	PERMEase
KY997_09795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KY997_09815	COG0167	dihydroorotate dehydrogenase activity
KY997_09820	COG0284	orotidine-5'-phosphate decarboxylase activity
KY997_09825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KY997_09835	COG0175	sulfate reduction
KY997_09850	COG0529	Catalyzes the synthesis of activated sulfate
KY997_09855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KY997_09880	COG1561	YicC-like family, N-terminal region
KY997_09885	COG2052	Domain of unknown function (DUF370)
KY997_09895	COG1758	RNA polymerase activity
KY997_09905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KY997_09910	COG0242	peptide deformylase activity
KY997_09920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KY997_09920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KY997_09925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KY997_09940	COG1162	GTPase activity
KY997_09945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KY997_09965	COG1302	Protein conserved in bacteria
KY997_09990	COG1349	DNA-binding transcription factor activity
KY997_10000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KY997_10005	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_10010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY997_10015	COG0571	ribonuclease III activity
KY997_10025	COG0552	protein localization to endoplasmic reticulum
KY997_10030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
KY997_10035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KY997_10040	COG0228	four-way junction DNA binding
KY997_10045	COG1837	Belongs to the UPF0109 family
KY997_10055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KY997_10065	COG0335	large ribosomal subunit rRNA binding
KY997_10070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KY997_10075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KY997_10085	COG2257	FlhB HrpN YscU SpaS Family
KY997_10090	COG0045	succinate-CoA ligase (ADP-forming) activity
KY997_10095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KY997_10100	COG0758	DNA mediated transformation
KY997_10105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KY997_10110	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KY997_10120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KY997_10125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KY997_10130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KY997_10135	COG1815	bacterial-type flagellum-dependent cell motility
KY997_10140	COG1558	bacterial-type flagellum-dependent cell motility
KY997_10145	COG1677	Flagellar hook-basal body complex protein FliE
KY997_10150	COG1766	The M ring may be actively involved in energy transduction
KY997_10155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KY997_10160	COG1317	bacterial-type flagellum organization
KY997_10170	COG2882	bacterial-type flagellum organization
KY997_10180	COG3144	bacterial-type flagellum assembly
KY997_10185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KY997_10190	COG4786	Flagellar basal body rod
KY997_10195	COG1582	Flagellar protein (FlbD)
KY997_10200	COG1580	Controls the rotational direction of flagella during chemotaxis
KY997_10205	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KY997_10210	COG1776	CheC inhibitor of MCP methylation
KY997_10210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KY997_10215	COG2201	protein-glutamate methylesterase activity
KY997_10225	COG1338	Plays a role in the flagellum-specific transport system
KY997_10230	COG1987	bacterial-type flagellum assembly
KY997_10235	COG1684	flagellar biosynthetic protein fliR
KY997_10240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KY997_10245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KY997_10250	COG1419	protein localization to endoplasmic reticulum
KY997_10255	COG0455	bacterial-type flagellum organization
KY997_10260	COG2201	protein-glutamate methylesterase activity
KY997_10270	COG0835	chemotaxis
KY997_10275	COG1776	CheC inhibitor of MCP methylation
KY997_10280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
KY997_10285	COG1191	sigma factor activity
KY997_10300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KY997_10305	COG0528	UMP kinase activity
KY997_10315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KY997_10320	COG4589	Belongs to the CDS family
KY997_10325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KY997_10330	COG0750	zinc metalloprotease
KY997_10335	COG0442	prolyl-tRNA aminoacylation
KY997_10340	COG2176	DNA-directed DNA polymerase activity
KY997_10365	COG0779	Required for maturation of 30S ribosomal subunits
KY997_10370	COG0195	Participates in both transcription termination and antitermination
KY997_10375	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KY997_10385	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KY997_10390	COG1550	Protein conserved in bacteria
KY997_10395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KY997_10410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KY997_10415	COG1185	polyribonucleotide nucleotidyltransferase activity
KY997_10420	COG0726	polysaccharide deacetylase
KY997_10430	COG1873	PFAM PRC-barrel domain
KY997_10440	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KY997_10450	COG0527	aspartate kinase activity
KY997_10460	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KY997_10465	COG0740	serine-type endopeptidase activity
KY997_10475	COG1674	ftsk spoiiie
KY997_10475	COG4980	gas vesicle protein
KY997_10480	COG2188	Transcriptional regulator
KY997_10490	COG0612	Peptidase, M16
KY997_10525	COG1546	Belongs to the CinA family
KY997_10525	COG1058	Belongs to the CinA family
KY997_10540	COG1692	metallophosphoesterase
KY997_10545	COG2359	stage V sporulation protein S
KY997_10555	COG1063	alcohol dehydrogenase
KY997_10565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KY997_10570	COG4550	Control of competence regulator ComK, YlbF/YmcA
KY997_10590	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KY997_10600	COG0457	Tetratricopeptide repeat
KY997_10630	COG0523	cobalamin synthesis protein
KY997_10660	COG1231	oxidoreductase activity
KY997_10665	COG3619	membrane
KY997_10680	COG2267	carboxylic ester hydrolase activity
KY997_10700	COG0393	Putative heavy-metal-binding
KY997_10705	COG0398	Pfam SNARE associated Golgi protein
KY997_10710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KY997_10715	COG1819	glycosyl
KY997_10720	COG0531	amino acid
KY997_10725	COG5577	PFAM Coat F domain
KY997_10745	COG3631	Ketosteroid isomerase-related protein
KY997_10760	COG1764	response to oxidative stress
KY997_10770	COG2076	Multidrug Resistance protein
KY997_10785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KY997_10790	COG1923	regulation of RNA biosynthetic process
KY997_10800	COG1780	Probably involved in ribonucleotide reductase function
KY997_10810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY997_10815	COG4112	unkown
KY997_10830	COG0735	belongs to the Fur family
KY997_10840	COG0697	spore germination
KY997_10880	COG1309	transcriptional regulator
KY997_10915	COG4282	regulation of fungal-type cell wall biogenesis
KY997_10975	COG0457	Tetratricopeptide repeat
KY997_10990	COG0831	urea catabolic process
KY997_10995	COG0832	Belongs to the urease beta subunit family
KY997_11005	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KY997_11010	COG0830	nickel cation binding
KY997_11015	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KY997_11030	COG1695	Transcriptional regulator
KY997_11045	COG0464	growth
KY997_11060	COG4282	regulation of fungal-type cell wall biogenesis
KY997_11070	COG5444	nuclease activity
KY997_11105	COG0457	Tetratricopeptide repeat
KY997_11125	COG5632	N-Acetylmuramoyl-L-alanine amidase
KY997_11315	COG4373	Mu-like prophage FluMu protein gp28
KY997_11475	COG3655	Transcriptional regulator
KY997_11545	COG1404	Belongs to the peptidase S8 family
KY997_11575	COG0582	viral genome integration into host DNA
KY997_11615	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KY997_11620	COG4474	Belongs to the UPF0398 family
KY997_11655	COG1793	dna ligase
KY997_11715	COG2887	Belongs to the helicase family. UvrD subfamily
KY997_11735	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KY997_11830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY997_11850	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KY997_11855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_11865	COG0756	dUTP diphosphatase activity
KY997_11885	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
KY997_11910	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KY997_11930	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
KY997_11940	COG3331	DNA recombination
KY997_11955	COG0464	growth
KY997_11965	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KY997_11970	COG0789	Transcriptional regulator
KY997_12020	COG0490	domain, Protein
KY997_12025	COG0475	glutathione-regulated potassium exporter activity
KY997_12070	COG1309	transcriptional regulator
KY997_12075	COG2076	Multidrug Resistance protein
KY997_12100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_12105	COG3546	catalase activity
KY997_12130	COG1846	Transcriptional regulator
KY997_12145	COG0655	NAD(P)H dehydrogenase (quinone) activity
KY997_12165	COG3209	COG3209 Rhs family protein
KY997_12175	COG1388	LysM domain
KY997_12180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KY997_12185	COG4224	UPF0291 protein
KY997_12190	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KY997_12200	COG3763	UPF0154 protein
KY997_12210	COG0785	Cytochrome C biogenesis protein
KY997_12215	COG2201	protein-glutamate methylesterase activity
KY997_12220	COG4846	Membrane protein involved in cytochrome C biogenesis
KY997_12230	COG0071	Belongs to the small heat shock protein (HSP20) family
KY997_12245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KY997_12250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_12270	COG0824	Thioesterase
KY997_12290	COG4841	protein insertion into membrane
KY997_12295	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KY997_12300	COG1832	CoA-binding protein
KY997_12330	COG2160	L-arabinose isomerase activity
KY997_12350	COG1115	amino acid carrier protein
KY997_12365	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KY997_12370	COG1140	nitrate reductase beta subunit
KY997_12375	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KY997_12395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KY997_12430	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
KY997_12450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY997_12475	COG3420	alginic acid biosynthetic process
KY997_12515	COG1012	belongs to the aldehyde dehydrogenase family
KY997_12525	COG1960	acyl-CoA dehydrogenase activity
KY997_12535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY997_12535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KY997_12535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_12560	COG1131	(ABC) transporter
KY997_12565	COG1725	Transcriptional regulator
KY997_12570	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_12575	COG1312	Catalyzes the dehydration of D-mannonate
KY997_12605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KY997_12610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KY997_12615	COG0640	Transcriptional regulator
KY997_12635	COG1649	PFAM Uncharacterised BCR, COG1649
KY997_12640	COG2404	hydrolase activity, acting on ester bonds
KY997_12645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KY997_12685	COG1252	NADH dehydrogenase
KY997_12695	COG0166	Belongs to the GPI family
KY997_12705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY997_12710	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KY997_12715	COG1024	Enoyl-CoA hydratase
KY997_12720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KY997_12725	COG0511	ligase activity, forming carbon-carbon bonds
KY997_12730	COG0439	Biotin carboxylase
KY997_12735	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KY997_12735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY997_12760	COG0318	PFAM AMP-dependent synthetase and ligase
KY997_12765	COG1960	acyl-CoA dehydrogenase activity
KY997_12770	COG2249	NAD(P)H dehydrogenase (quinone) activity
KY997_12775	COG1733	regulation of RNA biosynthetic process
KY997_12795	COG2323	membrane
KY997_12815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_12820	COG4948	Mandelate Racemase Muconate Lactonizing
KY997_12830	COG0463	Glycosyl transferase, family 2
KY997_12845	COG0493	'glutamate synthase
KY997_12885	COG1132	(ABC) transporter
KY997_12895	COG0300	oxidoreductase activity
KY997_12900	COG0574	Belongs to the PEP-utilizing enzyme family
KY997_12900	COG3848	Pyruvate phosphate dikinase
KY997_12905	COG0477	Major facilitator Superfamily
KY997_12915	COG1846	Transcriptional regulator
KY997_12945	COG0697	spore germination
KY997_12960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KY997_12965	COG1404	Belongs to the peptidase S8 family
KY997_12975	COG1309	transcriptional regulator
KY997_12980	COG1846	Transcriptional regulator
KY997_13010	COG1309	transcriptional regulator
KY997_13015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY997_13060	COG0741	lytic transglycosylase activity
KY997_13065	COG1086	Polysaccharide biosynthesis protein
KY997_13085	COG2322	membrane
KY997_13100	COG1619	proteins homologs of microcin C7 resistance protein MccF
KY997_13105	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY997_13110	COG3584	3D domain protein
KY997_13110	COG1388	LysM domain
KY997_13115	COG0514	ATP-dependent DNA helicase (RecQ)
KY997_13135	COG2315	Protein conserved in bacteria
KY997_13145	COG2427	Protein of unknown function (DUF1641)
KY997_13165	COG5444	nuclease activity
KY997_13180	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KY997_13215	COG2350	Protein conserved in bacteria
KY997_13250	COG2267	carboxylic ester hydrolase activity
KY997_13265	COG1280	lysine exporter protein (LysE YggA)
KY997_13270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
KY997_13305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KY997_13325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KY997_13340	COG1012	belongs to the aldehyde dehydrogenase family
KY997_13365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KY997_13385	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY997_13400	COG0714	Associated with various cellular activities
KY997_13405	COG2032	superoxide dismutase activity
KY997_13410	COG0791	NLP P60 protein
KY997_13410	COG1388	LysM domain
KY997_13420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY997_13425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY997_13435	COG2962	Rard protein
KY997_13445	COG4305	rare lipoprotein A
KY997_13460	COG1733	regulation of RNA biosynthetic process
KY997_13480	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY997_13490	COG2226	methyltransferase
KY997_13505	COG0813	purine-nucleoside phosphorylase activity
KY997_13545	COG4479	Belongs to the UPF0346 family
KY997_13560	COG0456	acetyltransferase
KY997_13600	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KY997_13605	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
KY997_13610	COG1846	Transcriptional regulator
KY997_13625	COG0534	Mate efflux family protein
KY997_13640	COG4698	Protein conserved in bacteria
KY997_13650	COG1999	signal sequence binding
KY997_13675	COG1272	protein, Hemolysin III
KY997_13680	COG0204	Acyl-transferase
KY997_13685	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KY997_13690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KY997_13720	COG1418	mRNA catabolic process
KY997_13725	COG0386	Belongs to the glutathione peroxidase family
KY997_13735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
KY997_13740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KY997_13750	COG1278	Cold shock
KY997_13770	COG0328	RNA-DNA hybrid ribonuclease activity
KY997_13775	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KY997_13780	COG0328	RNA-DNA hybrid ribonuclease activity
KY997_13790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KY997_13815	COG1755	Isoprenylcysteine carboxyl methyltransferase
KY997_13835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KY997_13840	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KY997_13845	COG1199	ATP-dependent helicase activity
KY997_13870	COG3599	regulation of cell shape
KY997_13875	COG4474	Belongs to the UPF0398 family
KY997_13895	COG2190	(PTS) system
KY997_13940	COG4499	WXG100 protein secretion system (Wss), protein YukC
KY997_13940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KY997_13950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KY997_13960	COG0017	Asparaginyl-tRNA synthetase
KY997_13965	COG0436	Aminotransferase
KY997_13970	COG5353	protein conserved in bacteria
KY997_13985	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KY997_13990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KY997_13995	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KY997_14010	COG0438	transferase activity, transferring glycosyl groups
KY997_14015	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KY997_14020	COG1803	Methylglyoxal synthase
KY997_14025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
KY997_14035	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_14045	COG4347	Protein of unknown function (DUF1405)
KY997_14055	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KY997_14055	COG2010	Cytochrome c
KY997_14060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KY997_14065	COG0723	plastoquinol--plastocyanin reductase activity
KY997_14075	COG5582	Belongs to the UPF0302 family
KY997_14080	COG0457	Tetratricopeptide repeat
KY997_14095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KY997_14100	COG0159	tryptophan synthase activity
KY997_14110	COG0135	phosphoribosylanthranilate isomerase activity
KY997_14120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KY997_14130	COG4401	Chorismate mutase type I
KY997_14135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KY997_14145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KY997_14150	COG0105	UTP biosynthetic process
KY997_14155	COG0142	geranyltranstransferase activity
KY997_14160	COG2226	methyltransferase
KY997_14180	COG0776	regulation of translation
KY997_14185	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KY997_14200	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KY997_14205	COG1160	GTP binding
KY997_14230	COG1304	FMN binding
KY997_14235	COG0539	negative regulation of cytoplasmic translation
KY997_14240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KY997_14260	COG2339	peptidase activity
KY997_14275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KY997_14285	COG1408	metallophosphoesterase
KY997_14305	COG1266	CAAX protease self-immunity
KY997_14310	COG0514	ATP-dependent DNA helicase (RecQ)
KY997_14315	COG4955	Helix-turn-helix domain
KY997_14320	COG1141	Ferredoxin
KY997_14325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KY997_14330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KY997_14335	COG0739	heme binding
KY997_14345	COG1595	DNA-templated transcription, initiation
KY997_14350	COG1316	TRANSCRIPTIONal
KY997_14370	COG0745	RESPONSE REGULATOR receiver
KY997_14380	COG0745	RESPONSE REGULATOR receiver
KY997_14385	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KY997_14390	COG1333	cytochrome c biogenesis protein
KY997_14395	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_14400	COG1187	pseudouridine synthase activity
KY997_14405	COG0700	Nucleoside recognition
KY997_14410	COG2715	membrane protein required for spore maturation
KY997_14415	COG1686	Belongs to the peptidase S11 family
KY997_14425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KY997_14430	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
KY997_14450	COG0456	acetyltransferase
KY997_14455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KY997_14470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KY997_14470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KY997_14500	COG4086	secreted protein
KY997_14505	COG4195	phage-related replication protein
KY997_14510	COG0019	diaminopimelate decarboxylase activity
KY997_14580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KY997_14585	COG4974	Belongs to the 'phage' integrase family
KY997_14600	COG1300	Membrane
KY997_14605	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_14615	COG1953	Uracil, thiamine, allantoin
KY997_14625	COG2153	protein acetylation
KY997_14630	COG1379	DNA repair
KY997_14675	COG4918	Iron-sulphur cluster biosynthesis
KY997_14690	COG2329	Antibiotic biosynthesis monooxygenase
KY997_14700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KY997_14710	COG0747	negative chemotaxis
KY997_14720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY997_14725	COG0444	Belongs to the ABC transporter superfamily
KY997_14735	COG0534	Mate efflux family protein
KY997_14750	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KY997_14765	COG0346	lactoylglutathione lyase activity
KY997_14805	COG2205	protein histidine kinase activity
KY997_14810	COG0745	RESPONSE REGULATOR receiver
KY997_14830	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KY997_14850	COG0300	oxidoreductase activity
KY997_14855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY997_14860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KY997_14870	COG1902	pentaerythritol trinitrate reductase activity
KY997_14880	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KY997_14905	COG2358	TRAP transporter, solute receptor (TAXI family
KY997_14910	COG2188	Transcriptional regulator
KY997_14915	COG2723	6-phospho-beta-galactosidase activity
KY997_14920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_14925	COG1447	Phosphotransferase system cellobiose-specific component IIA
KY997_14930	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_14940	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_14945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KY997_14950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KY997_14960	COG0706	membrane insertase activity
KY997_14980	COG4129	membrane
KY997_15005	COG1597	lipid kinase activity
KY997_15010	COG0508	dehydrogenase complex catalyzes the overall conversion of
KY997_15015	COG0022	dehydrogenase e1 component
KY997_15020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KY997_15025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KY997_15030	COG3426	butyrate kinase activity
KY997_15040	COG0280	phosphate acetyltransferase
KY997_15055	COG0584	glycerophosphoryl diester phosphodiesterase
KY997_15060	COG0860	N-Acetylmuramoyl-L-alanine amidase
KY997_15080	COG0745	RESPONSE REGULATOR receiver
KY997_15085	COG0750	zinc metalloprotease
KY997_15090	COG0497	DNA recombination
KY997_15095	COG1438	arginine binding
KY997_15100	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KY997_15110	COG0142	geranyltranstransferase activity
KY997_15115	COG1722	exodeoxyribonuclease VII activity
KY997_15130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KY997_15135	COG1302	Protein conserved in bacteria
KY997_15140	COG0439	Biotin carboxylase
KY997_15145	COG0511	ligase activity, forming carbon-carbon bonds
KY997_15185	COG3854	ATPases associated with a variety of cellular activities
KY997_15200	COG0006	proline dipeptidase activity
KY997_15205	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KY997_15215	COG3872	metal-dependent enzyme
KY997_15230	COG1321	iron dependent repressor
KY997_15235	COG0095	Lipoate-protein ligase
KY997_15240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY997_15245	COG2113	Glycine betaine
KY997_15250	COG4176	ABC-type proline glycine betaine transport system permease component
KY997_15260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KY997_15270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KY997_15300	COG0681	Belongs to the peptidase S26 family
KY997_15325	COG4940	Competence protein ComGF
KY997_15340	COG4537	Required for transformation and DNA binding
KY997_15345	COG1459	type II secretion system
KY997_15350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KY997_15355	COG1366	Belongs to the anti-sigma-factor antagonist family
KY997_15365	COG1393	Belongs to the ArsC family
KY997_15385	COG0011	TIGRFAM Protein of
KY997_15400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY997_15405	COG1368	sulfuric ester hydrolase activity
KY997_15410	COG1940	carbohydrate kinase activity
KY997_15415	COG4483	Protein conserved in bacteria
KY997_15435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KY997_15440	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KY997_15525	COG0573	inorganic phosphate transmembrane transporter activity
KY997_15530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KY997_15545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KY997_15550	COG2839	Protein conserved in bacteria
KY997_15555	COG5521	maltodextrose utilization protein MalA
KY997_15560	COG1388	LysM domain
KY997_15570	COG4709	membrane
KY997_15575	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KY997_15580	COG0735	belongs to the Fur family
KY997_15595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_15605	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KY997_15620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KY997_15625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KY997_15630	COG2384	SAM-dependent methyltransferase
KY997_15670	COG2010	Cytochrome c
KY997_15685	COG0358	DNA primase activity
KY997_15690	COG1671	Belongs to the UPF0178 family
KY997_15700	COG0517	IMP dehydrogenase activity
KY997_15710	COG0752	glycyl-tRNA synthetase alpha subunit
KY997_15715	COG1381	Involved in DNA repair and RecF pathway recombination
KY997_15725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KY997_15730	COG0295	cytidine deaminase activity
KY997_15735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KY997_15740	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KY997_15770	COG4864	UPF0365 protein
KY997_15785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KY997_15805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KY997_15815	COG0484	heat shock protein binding
KY997_15825	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KY997_15840	COG0481	GTPase activity
KY997_15855	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
KY997_15860	COG0268	Binds directly to 16S ribosomal RNA
KY997_15885	COG2131	deaminase
KY997_15895	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KY997_15900	COG2226	methyltransferase
KY997_15905	COG0799	negative regulation of ribosome biogenesis
KY997_15910	COG1713	HD superfamily hydrolase involved in NAD metabolism
KY997_15920	COG1534	Rna-binding protein
KY997_15925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KY997_15930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KY997_15935	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KY997_15950	COG2755	lipolytic protein G-D-S-L family
KY997_15960	COG5609	conserved protein (DUF2294)
KY997_15965	COG3383	formate dehydrogenase (NAD+) activity
KY997_15970	COG2427	Protein of unknown function (DUF1641)
KY997_15995	COG0251	oxidation-reduction process
KY997_16005	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY997_16010	COG0251	oxidation-reduction process
KY997_16025	COG1247	-acetyltransferase
KY997_16055	COG1447	Phosphotransferase system cellobiose-specific component IIA
KY997_16060	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_16070	COG2181	nitrate reductase activity
KY997_16075	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KY997_16085	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KY997_16090	COG2223	nitrite transmembrane transporter activity
KY997_16125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_16130	COG0730	response to heat
KY997_16135	COG0425	Belongs to the sulfur carrier protein TusA family
KY997_16140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY997_16140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY997_16145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY997_16145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY997_16150	COG2210	Belongs to the sulfur carrier protein TusA family
KY997_16155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY997_16155	COG0425	Belongs to the sulfur carrier protein TusA family
KY997_16160	COG1054	Belongs to the UPF0176 family
KY997_16170	COG1937	Protein conserved in bacteria
KY997_16200	COG1942	4-Oxalocrotonate Tautomerase
KY997_16205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KY997_16210	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KY997_16230	COG2197	response regulator
KY997_16240	COG0747	negative chemotaxis
KY997_16250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KY997_16255	COG0444	Belongs to the ABC transporter superfamily
KY997_16260	COG4608	Belongs to the ABC transporter superfamily
KY997_16280	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_16290	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
KY997_16325	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_16330	COG1621	beta-fructofuranosidase activity
KY997_16335	COG3716	PTS system mannose fructose sorbose family IID component
KY997_16340	COG3715	PTS system
KY997_16345	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_16375	COG2169	Transcriptional regulator
KY997_16380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KY997_16395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
KY997_16410	COG0656	L-ascorbic acid biosynthetic process
KY997_16420	COG1733	regulation of RNA biosynthetic process
KY997_16430	COG1587	Uroporphyrinogen-III synthase
KY997_16440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY997_16445	COG0583	DNA-binding transcription factor activity
KY997_16450	COG2814	Major facilitator Superfamily
KY997_16465	COG1309	transcriptional regulator
KY997_16480	COG2226	methyltransferase
KY997_16505	COG0626	cystathionine gamma-synthase activity
KY997_16510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY997_16515	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KY997_16520	COG2226	methyltransferase
KY997_16540	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
KY997_16545	COG0572	uridine kinase
KY997_16555	COG0826	peptidase U32
KY997_16560	COG4122	O-methyltransferase activity
KY997_16565	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KY997_16580	COG4472	Bacterial protein of unknown function (DUF965)
KY997_16590	COG0628	permease
KY997_16605	COG3881	PFAM PRC-barrel domain
KY997_16615	COG0457	Tetratricopeptide repeat
KY997_16620	COG0482	sulfurtransferase activity
KY997_16625	COG1104	cysteine desulfurase activity
KY997_16630	COG1959	2 iron, 2 sulfur cluster binding
KY997_16640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KY997_16655	COG0124	histidyl-tRNA synthetase
KY997_16680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KY997_16685	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KY997_16685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KY997_16690	COG5416	Lipopolysaccharide assembly protein A domain
KY997_16710	COG2323	membrane
KY997_16720	COG1862	Preprotein translocase
KY997_16730	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KY997_16740	COG2255	four-way junction helicase activity
KY997_16745	COG0632	four-way junction helicase activity
KY997_16765	COG2318	DinB family
KY997_16770	COG4195	phage-related replication protein
KY997_16785	COG0217	transcriptional regulatory protein
KY997_16795	COG1388	LysM domain
KY997_16815	COG1104	cysteine desulfurase activity
KY997_16820	COG1827	regulation of RNA biosynthetic process
KY997_16835	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KY997_16840	COG3290	protein histidine kinase activity
KY997_16845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KY997_16850	COG2868	ribosomal protein
KY997_16855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KY997_16860	COG1994	Peptidase M50
KY997_16865	COG0739	heme binding
KY997_16870	COG3832	glyoxalase III activity
KY997_16875	COG0640	Transcriptional regulator
KY997_16880	COG2894	cell division
KY997_16885	COG0850	regulation of cytokinetic process
KY997_16890	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KY997_16900	COG1077	Cell shape determining protein MreB Mrl
KY997_16905	COG2003	Belongs to the UPF0758 family
KY997_16910	COG0424	maF-like protein
KY997_16915	COG2801	Transposase and inactivated derivatives
KY997_16930	COG0285	dihydrofolate synthase activity
KY997_16935	COG0525	valine-tRNA ligase activity
KY997_16945	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KY997_16950	COG1388	LysM domain
KY997_16955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KY997_16960	COG0113	porphobilinogen synthase activity
KY997_16970	COG0181	hydroxymethylbilane synthase activity
KY997_16975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KY997_16990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
KY997_16995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KY997_17005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KY997_17010	COG0544	peptidyl-prolyl cis-trans isomerase activity
KY997_17015	COG1477	protein flavinylation
KY997_17015	COG0457	Tetratricopeptide repeat
KY997_17020	COG0066	3-isopropylmalate dehydratase activity
KY997_17030	COG0473	3-isopropylmalate dehydrogenase activity
KY997_17035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KY997_17040	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KY997_17045	COG0440	acetolactate synthase activity
KY997_17050	COG0028	Belongs to the TPP enzyme family
KY997_17055	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KY997_17065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KY997_17090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KY997_17100	COG5401	PFAM Sporulation and spore germination
KY997_17110	COG1846	Transcriptional regulator
KY997_17115	COG2197	response regulator
KY997_17120	COG4221	oxidoreductase activity
KY997_17125	COG0824	Thioesterase
KY997_17130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KY997_17135	COG1053	succinate dehydrogenase
KY997_17140	COG2009	succinate dehydrogenase
KY997_17155	COG0322	excinuclease ABC activity
KY997_17160	COG3118	belongs to the thioredoxin family
KY997_17165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KY997_17175	COG1024	Enoyl-CoA hydratase
KY997_17180	COG1309	transcriptional regulator
KY997_17185	COG0318	PFAM AMP-dependent synthetase and ligase
KY997_17190	COG3766	membrane
KY997_17195	COG1193	negative regulation of DNA recombination
KY997_17205	COG1286	toxin biosynthetic process
KY997_17210	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
KY997_17230	COG0072	phenylalanine-tRNA ligase activity
KY997_17230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KY997_17240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KY997_17250	COG1966	Carbon starvation protein
KY997_17255	COG1309	transcriptional regulator
KY997_17260	COG3402	PFAM membrane-flanked domain
KY997_17290	COG1653	transport
KY997_17295	COG0371	Dehydrogenase
KY997_17300	COG0235	Class ii aldolase
KY997_17310	COG2160	L-arabinose isomerase activity
KY997_17315	COG3507	Belongs to the glycosyl hydrolase 43 family
KY997_17330	COG3326	Membrane
KY997_17335	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KY997_17340	COG0291	Belongs to the bacterial ribosomal protein bL35 family
KY997_17345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KY997_17350	COG1346	cytolysis
KY997_17365	COG3279	Response regulator of the LytR AlgR family
KY997_17380	COG1011	Hydrolase
KY997_17385	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KY997_17405	COG3611	Membrane attachment protein
KY997_17410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KY997_17420	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KY997_17425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KY997_17430	COG3866	Pectate lyase
KY997_17435	COG0237	dephospho-CoA kinase activity
KY997_17440	COG1971	Probably functions as a manganese efflux pump
KY997_17445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KY997_17470	COG0538	isocitrate dehydrogenase activity
KY997_17480	COG2273	Hydrolase Family 16
KY997_17490	COG2707	UPF0756 membrane protein
KY997_17500	COG3030	protein affecting phage T7 exclusion by the F plasmid
KY997_17510	COG0205	6-phosphofructokinase activity
KY997_17525	COG0281	malic enzyme
KY997_17550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KY997_17560	COG4109	DRTGG domain
KY997_17570	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KY997_17575	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_17590	COG0137	argininosuccinate synthase activity
KY997_17600	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
KY997_17605	COG0827	DNA restriction-modification system
KY997_17610	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KY997_17625	COG1714	RDD family
KY997_17635	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KY997_17640	COG1846	Transcriptional regulator
KY997_17645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY997_17655	COG0301	tRNA thio-modification
KY997_17665	COG1114	Component of the transport system for branched-chain amino acids
KY997_17670	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
KY997_17675	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KY997_17680	COG1309	transcriptional regulator
KY997_17695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KY997_17715	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KY997_17720	COG0454	-acetyltransferase
KY997_17725	COG0517	IMP dehydrogenase activity
KY997_17735	COG1360	Flagellar Motor Protein
KY997_17750	COG1605	Chorismate mutase
KY997_17750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KY997_17760	COG3118	belongs to the thioredoxin family
KY997_17765	COG4980	gas vesicle protein
KY997_17770	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KY997_17775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KY997_17780	COG1674	ftsk spoiiie
KY997_17785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KY997_17795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_17805	COG1363	Peptidase, m42
KY997_17810	COG5584	Small secreted protein
KY997_17820	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KY997_17825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KY997_17855	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KY997_17860	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KY997_17880	COG2252	PERMEase
KY997_17890	COG4473	ABC transporter
KY997_17895	COG1131	(ABC) transporter
KY997_17900	COG1349	DNA-binding transcription factor activity
KY997_17910	COG2244	polysaccharide biosynthetic process
KY997_17915	COG2081	HI0933 family
KY997_17920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KY997_17930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KY997_17950	COG5578	integral membrane protein
KY997_17955	COG0673	inositol 2-dehydrogenase activity
KY997_17960	COG1653	transport
KY997_17985	COG0395	ABC-type sugar transport system, permease component
KY997_17990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY997_17995	COG1073	alpha beta
KY997_18005	COG0583	DNA-binding transcription factor activity
KY997_18010	COG0346	lactoylglutathione lyase activity
KY997_18025	COG2814	Major facilitator Superfamily
KY997_18030	COG1464	Belongs to the NlpA lipoprotein family
KY997_18045	COG1136	(ABC) transporter
KY997_18060	COG1725	Transcriptional regulator
KY997_18070	COG1242	4 iron, 4 sulfur cluster binding
KY997_18075	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KY997_18085	COG2267	carboxylic ester hydrolase activity
KY997_18090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KY997_18095	COG0671	phosphoesterase, PA-phosphatase related
KY997_18100	COG0438	transferase activity, transferring glycosyl groups
KY997_18100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KY997_18105	COG0367	asparagine synthase
KY997_18110	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KY997_18130	COG1506	peptidase
KY997_18135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KY997_18145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KY997_18150	COG0494	nUDIX hydrolase
KY997_18160	COG4824	toxin secretion phage lysis holin
KY997_18165	COG0783	Belongs to the Dps family
KY997_18180	COG1854	S-ribosylhomocysteine lyase activity
KY997_18185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KY997_18190	COG0288	reversible hydration of carbon dioxide
KY997_18205	COG0254	rRNA binding
KY997_18210	COG1271	oxidase subunit
KY997_18215	COG1294	oxidase, subunit
KY997_18235	COG0318	PFAM AMP-dependent synthetase and ligase
KY997_18240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KY997_18245	COG0596	Alpha beta hydrolase
KY997_18260	COG1575	Belongs to the MenA family. Type 1 subfamily
KY997_18270	COG0058	SHG alpha-glucan phosphorylase activity
KY997_18280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KY997_18415	COG3859	Proton-coupled thiamine transporter YuaJ
KY997_18420	COG3764	Sortase (surface protein transpeptidase)
KY997_18435	COG0457	Tetratricopeptide repeat
KY997_18440	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
KY997_18445	COG0569	domain protein
KY997_18470	COG1454	alcohol dehydrogenase
KY997_18480	COG1510	regulation of RNA biosynthetic process
KY997_18490	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KY997_18510	COG1397	ADP-ribosylglycohydrolase
KY997_18575	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
KY997_18600	COG1408	metallophosphoesterase
KY997_18605	COG1968	undecaprenyl-diphosphatase activity
KY997_18610	COG0628	permease
KY997_18615	COG0673	inositol 2-dehydrogenase activity
KY997_18620	COG0693	protein deglycase activity
KY997_18630	COG0840	transmembrane signaling receptor activity
KY997_18635	COG0840	transmembrane signaling receptor activity
KY997_18645	COG2070	2-Nitropropane dioxygenase
KY997_18650	COG0432	Pfam Uncharacterised protein family UPF0047
KY997_18670	COG5297	Belongs to the glycosyl hydrolase family 6
KY997_18675	COG1253	flavin adenine dinucleotide binding
KY997_18680	COG2738	Putative neutral zinc metallopeptidase
KY997_18695	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KY997_18705	COG2323	membrane
KY997_18710	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KY997_18720	COG0166	Belongs to the GPI family
KY997_18725	COG1979	alcohol dehydrogenase
KY997_18730	COG2155	Conserved Protein
KY997_18735	COG1098	S1 RNA binding domain
KY997_18745	COG1522	sequence-specific DNA binding
KY997_18750	COG2267	carboxylic ester hydrolase activity
KY997_18780	COG5018	Exonuclease
KY997_18785	COG2814	Major facilitator Superfamily
KY997_18805	COG3290	protein histidine kinase activity
KY997_18810	COG4565	transcriptional regulatory protein
KY997_18815	COG1079	Belongs to the binding-protein-dependent transport system permease family
KY997_18820	COG1183	phosphatidylcholine synthase activity
KY997_18825	COG0586	Pfam SNARE associated Golgi protein
KY997_18830	COG0688	phosphatidylethanolamine metabolic process
KY997_18835	COG3493	citrate carrier protein
KY997_18845	COG2111	Na H antiporter
KY997_18855	COG0651	ATP synthesis coupled electron transport
KY997_18860	COG1863	multisubunit Na H antiporter MnhE subunit
KY997_18865	COG2212	antiporter activity
KY997_18870	COG1320	monovalent cation:proton antiporter activity
KY997_18875	COG2050	protein possibly involved in aromatic compounds catabolism
KY997_18915	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KY997_18920	COG1335	isochorismatase
KY997_18925	COG5506	Protein of unknown function (DUF1694)
KY997_18945	COG1959	2 iron, 2 sulfur cluster binding
KY997_18960	COG1418	mRNA catabolic process
KY997_18995	COG5417	Belongs to the EsaB family
KY997_19000	COG4842	Belongs to the WXG100 family
KY997_19005	COG1115	amino acid carrier protein
KY997_19010	COG2508	Transcriptional regulator
KY997_19010	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KY997_19025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KY997_19030	COG1268	BioY protein
KY997_19045	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KY997_19050	COG3584	3D domain protein
KY997_19070	COG0492	ferredoxin-NADP+ reductase activity
KY997_19085	COG0456	acetyltransferase
KY997_19090	COG0316	Belongs to the HesB IscA family
KY997_19095	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
KY997_19100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KY997_19105	COG4844	belongs to the
KY997_19115	COG2323	membrane
KY997_19120	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KY997_19125	COG5646	InterPro IPR014922
KY997_19140	COG0457	Tetratricopeptide repeat
KY997_19145	COG3479	Phenolic acid decarboxylase
KY997_19155	COG4837	Protein of unknown function (DUF1462)
KY997_19160	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KY997_19165	COG0823	Involved in the tonB-independent uptake of proteins
KY997_19165	COG4946	Tricorn protease homolog
KY997_19165	COG1506	peptidase
KY997_19170	COG0083	homoserine kinase activity
KY997_19175	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KY997_19180	COG0460	homoserine dehydrogenase
KY997_19190	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KY997_19195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KY997_19200	COG0647	UMP catabolic process
KY997_19205	COG2445	Protein of unknown function DUF86
KY997_19210	COG4470	Protein conserved in bacteria
KY997_19225	COG0739	heme binding
KY997_19240	COG0733	neurotransmitter:sodium symporter activity
KY997_19250	COG3377	Domain of unknown function (DUF1805)
KY997_19255	COG0737	Belongs to the 5'-nucleotidase family
KY997_19260	COG0730	response to heat
KY997_19265	COG1801	Protein of unknown function DUF72
KY997_19275	COG3226	Transcriptional regulator
KY997_19280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KY997_19295	COG1288	antiporter activity
KY997_19300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
KY997_19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KY997_19335	COG0457	Tetratricopeptide repeat
KY997_19345	COG0719	Fe-S assembly protein
KY997_19350	COG0822	iron-sulfur transferase activity
KY997_19355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY997_19360	COG0719	Fe-S assembly protein
KY997_19365	COG0396	ATPase activity
KY997_19375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KY997_19380	COG1464	Belongs to the NlpA lipoprotein family
KY997_19385	COG2011	ABC-type metal ion transport system permease component
KY997_19390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KY997_19400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KY997_19415	COG0509	glycine decarboxylation via glycine cleavage system
KY997_19420	COG1393	Belongs to the ArsC family
KY997_19430	COG0183	Belongs to the thiolase family
KY997_19450	COG5577	PFAM Coat F domain
KY997_19465	COG1120	ATPase activity
KY997_19470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_19480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY997_19495	COG1686	Belongs to the peptidase S11 family
KY997_19500	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_19505	COG0783	Belongs to the Dps family
KY997_19510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY997_19515	COG0745	RESPONSE REGULATOR receiver
KY997_19520	COG2770	Histidine kinase
KY997_19520	COG2205	protein histidine kinase activity
KY997_19530	COG1309	transcriptional regulator
KY997_19535	COG0114	fumarate hydratase activity
KY997_19550	COG0814	amino acid
KY997_19565	COG2197	response regulator
KY997_19570	COG4585	Histidine kinase
KY997_19575	COG4758	membrane
KY997_19580	COG3595	metallopeptidase activity
KY997_19585	COG1842	Phage shock protein A
KY997_19595	COG4677	pectinesterase activity
KY997_19600	COG2096	Adenosyltransferase
KY997_19605	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_19625	COG1454	alcohol dehydrogenase
KY997_19655	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_19660	COG2258	MOSC domain
KY997_19665	COG0583	DNA-binding transcription factor activity
KY997_19675	COG2721	sulfolactate sulfo-lyase activity
KY997_19680	COG0246	Mannitol dehydrogenase
KY997_19685	COG1609	Transcriptional regulator
KY997_19690	COG2211	Major facilitator Superfamily
KY997_19695	COG1904	glucuronate isomerase
KY997_19700	COG2205	protein histidine kinase activity
KY997_19705	COG0745	RESPONSE REGULATOR receiver
KY997_19710	COG1120	ATPase activity
KY997_19715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_19735	COG1988	membrane-bound metal-dependent
KY997_19740	COG1368	sulfuric ester hydrolase activity
KY997_19745	COG2814	Major facilitator Superfamily
KY997_19750	COG0656	L-ascorbic acid biosynthetic process
KY997_19760	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KY997_19770	COG0596	Alpha beta hydrolase
KY997_19780	COG2860	membrane
KY997_19790	COG0456	acetyltransferase
KY997_19795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KY997_19800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KY997_19805	COG2217	Heavy metal translocating P-type atpase
KY997_19815	COG1175	transmembrane transport
KY997_19830	COG1472	Belongs to the glycosyl hydrolase 3 family
KY997_19835	COG1121	(ABC) transporter
KY997_19840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KY997_19875	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_19900	COG2608	mercury ion transmembrane transporter activity
KY997_19905	COG1937	Protein conserved in bacteria
KY997_19910	COG0693	protein deglycase activity
KY997_19915	COG1349	DNA-binding transcription factor activity
KY997_19925	COG4952	isomerase
KY997_19940	COG2814	Major facilitator Superfamily
KY997_19945	COG2814	Major facilitator Superfamily
KY997_19955	COG2124	cytochrome p450
KY997_19965	COG1846	Transcriptional regulator
KY997_19975	COG0673	inositol 2-dehydrogenase activity
KY997_19980	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KY997_19985	COG1396	sequence-specific DNA binding
KY997_20010	COG1191	sigma factor activity
KY997_20055	COG5520	Belongs to the glycosyl hydrolase 30 family
KY997_20060	COG3507	Belongs to the glycosyl hydrolase 43 family
KY997_20100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KY997_20115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KY997_20120	COG2002	toxin-antitoxin pair type II binding
KY997_20125	COG1476	TRANSCRIPTIONal
KY997_20130	COG1396	sequence-specific DNA binding
KY997_20135	COG1396	sequence-specific DNA binding
KY997_20140	COG1174	glycine betaine transport
KY997_20145	COG1732	Glycine betaine
KY997_20150	COG1174	glycine betaine transport
KY997_20160	COG1510	regulation of RNA biosynthetic process
KY997_20165	COG2095	MarC family integral membrane protein
KY997_20200	COG0693	protein deglycase activity
KY997_20205	COG0148	phosphopyruvate hydratase activity
KY997_20210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KY997_20215	COG0149	triose-phosphate isomerase activity
KY997_20220	COG0126	phosphoglycerate kinase activity
KY997_20225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KY997_20235	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY997_20260	COG1556	Lactate utilization protein
KY997_20305	COG0110	maltose O-acetyltransferase activity
KY997_20310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KY997_20315	COG2244	polysaccharide biosynthetic process
KY997_20320	COG1216	Glycosyl transferase, family 2
KY997_20330	COG1216	Glycosyl transferase, family 2
KY997_20340	COG0438	transferase activity, transferring glycosyl groups
KY997_20345	COG1215	transferase activity, transferring glycosyl groups
KY997_20350	COG0438	transferase activity, transferring glycosyl groups
KY997_20365	COG3944	biosynthesis protein
KY997_20370	COG1396	sequence-specific DNA binding
KY997_20380	COG2249	NAD(P)H dehydrogenase (quinone) activity
KY997_20395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
KY997_20410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KY997_20420	COG1733	regulation of RNA biosynthetic process
KY997_20425	COG1902	pentaerythritol trinitrate reductase activity
KY997_20430	COG1621	beta-fructofuranosidase activity
KY997_20455	COG0740	serine-type endopeptidase activity
KY997_20460	COG1611	Belongs to the LOG family
KY997_20465	COG1694	Mazg nucleotide pyrophosphohydrolase
KY997_20475	COG0659	secondary active sulfate transmembrane transporter activity
KY997_20480	COG0288	reversible hydration of carbon dioxide
KY997_20490	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KY997_20505	COG2732	(Barnase) inhibitor
KY997_20515	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_20535	COG1051	belongs to the nudix hydrolase family
KY997_20540	COG0492	ferredoxin-NADP+ reductase activity
KY997_20545	COG0457	Tetratricopeptide repeat
KY997_20550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY997_20555	COG0140	phosphoribosyl-ATP diphosphatase activity
KY997_20555	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KY997_20560	COG0107	imidazoleglycerol-phosphate synthase activity
KY997_20565	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KY997_20570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KY997_20575	COG0131	Imidazoleglycerol-phosphate dehydratase
KY997_20580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KY997_20585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KY997_20590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KY997_20595	COG4990	cell redox homeostasis
KY997_20600	COG5297	Belongs to the glycosyl hydrolase family 6
KY997_20605	COG0110	maltose O-acetyltransferase activity
KY997_20610	COG0546	phosphoglycolate phosphatase activity
KY997_20615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
KY997_20620	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KY997_20630	COG1846	Transcriptional regulator
KY997_20635	COG2814	Major facilitator Superfamily
KY997_20650	COG1983	PspC domain protein
KY997_20655	COG3595	metallopeptidase activity
KY997_20680	COG0556	nucleotide-excision repair
KY997_20685	COG4897	Protein conserved in bacteria
KY997_20695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KY997_20705	COG3409	Peptidoglycan-binding domain 1 protein
KY997_20705	COG0793	Belongs to the peptidase S41A family
KY997_20710	COG0473	3-isopropylmalate dehydrogenase activity
KY997_20730	COG2010	Cytochrome c
KY997_20735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_20745	COG0653	protein targeting
KY997_20765	COG1516	flagellar protein fliS
KY997_20770	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KY997_20775	COG1334	flagellar protein FlaG
KY997_20785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KY997_20790	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
KY997_20795	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
KY997_20815	COG3418	PFAM FlgN family protein
KY997_20820	COG2747	anti-sigma28 factor FlgM
KY997_20830	COG1040	competence protein
KY997_20840	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KY997_20850	COG2197	response regulator
KY997_20855	COG4585	Histidine kinase
KY997_20860	COG1739	Uncharacterized protein family UPF0029
KY997_20875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KY997_20885	COG1215	transferase activity, transferring glycosyl groups
KY997_20890	COG3206	protein involved in exopolysaccharide biosynthesis
KY997_20895	COG3307	-O-antigen
KY997_20900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KY997_20905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KY997_20915	COG2244	polysaccharide biosynthetic process
KY997_20925	COG2247	cell wall binding repeat
KY997_20925	COG0860	N-Acetylmuramoyl-L-alanine amidase
KY997_20935	COG1316	TRANSCRIPTIONal
KY997_20940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KY997_20950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY997_20955	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KY997_20960	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KY997_20970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KY997_20980	COG1682	transport, permease protein
KY997_20985	COG1134	teichoic acid transport
KY997_20990	COG4193	domain, Protein
KY997_21025	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
KY997_21030	COG0438	transferase activity, transferring glycosyl groups
KY997_21070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY997_21080	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
KY997_21085	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_21090	COG1063	alcohol dehydrogenase
KY997_21105	COG1316	TRANSCRIPTIONal
KY997_21110	COG0561	phosphatase activity
KY997_21115	COG0791	NLP P60 protein
KY997_21125	COG2843	Capsule synthesis protein
KY997_21135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KY997_21140	COG1609	Transcriptional regulator
KY997_21145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KY997_21150	COG1869	D-ribose catabolic process
KY997_21160	COG1172	Belongs to the binding-protein-dependent transport system permease family
KY997_21165	COG1879	ABC-type sugar transport system periplasmic component
KY997_21170	COG0583	DNA-binding transcription factor activity
KY997_21175	COG2226	methyltransferase
KY997_21180	COG3527	Alpha-acetolactate decarboxylase
KY997_21200	COG1522	sequence-specific DNA binding
KY997_21205	COG2059	Chromate
KY997_21210	COG2059	Chromate
KY997_21215	COG4464	protein tyrosine phosphatase activity
KY997_21230	COG4715	Zinc finger, swim domain protein
KY997_21235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KY997_21240	COG3878	Protein conserved in bacteria
KY997_21260	COG0561	phosphatase activity
KY997_21275	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_21285	COG3732	PTS system glucitol sorbitol-specific
KY997_21305	COG0629	single-stranded DNA binding
KY997_21320	COG1970	mechanosensitive ion channel activity
KY997_21325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KY997_21330	COG4786	Flagellar basal body rod
KY997_21335	COG4786	Flagellar basal body rod
KY997_21340	COG1077	Cell shape determining protein MreB Mrl
KY997_21345	COG1609	Transcriptional regulator
KY997_21350	COG1846	Transcriptional regulator
KY997_21355	COG2814	Major facilitator Superfamily
KY997_21360	COG0671	phosphoesterase, PA-phosphatase related
KY997_21365	COG1227	inorganic diphosphatase activity
KY997_21370	COG3546	catalase activity
KY997_21390	COG0517	IMP dehydrogenase activity
KY997_21395	COG0598	Magnesium transport protein CorA
KY997_21405	COG0004	ammonium transporteR
KY997_21410	COG0347	Belongs to the P(II) protein family
KY997_21415	COG0740	serine-type endopeptidase activity
KY997_21425	COG0739	heme binding
KY997_21430	COG1247	-acetyltransferase
KY997_21450	COG3251	PFAM MbtH domain protein
KY997_21460	COG3433	isochorismatase activity
KY997_21460	COG1535	isochorismatase
KY997_21465	COG1021	2,3-dihydroxybenzoate-AMP ligase
KY997_21470	COG1169	isochorismate synthase
KY997_21475	COG1028	Short-chain dehydrogenase reductase Sdr
KY997_21480	COG2819	hydrolase of the alpha beta superfamily
KY997_21485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_21490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_21495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY997_21510	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KY997_21520	COG1959	2 iron, 2 sulfur cluster binding
KY997_21530	COG1994	Peptidase M50
KY997_21535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KY997_21545	COG2223	nitrite transmembrane transporter activity
KY997_21555	COG2304	oxidoreductase activity
KY997_21560	COG2304	oxidoreductase activity
KY997_21570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KY997_21580	COG4836	Membrane
KY997_21585	COG0355	proton-transporting ATP synthase activity, rotational mechanism
KY997_21590	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
KY997_21600	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
KY997_21605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KY997_21610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KY997_21620	COG0356	it plays a direct role in the translocation of protons across the membrane
KY997_21635	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KY997_21645	COG0698	ribose 5-phosphate isomerase
KY997_21650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KY997_21665	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KY997_21680	COG0673	inositol 2-dehydrogenase activity
KY997_21685	COG0561	phosphatase activity
KY997_21690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KY997_21700	COG2890	protein-(glutamine-N5) methyltransferase activity
KY997_21705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KY997_21710	COG0346	lactoylglutathione lyase activity
KY997_21720	COG0679	Auxin Efflux Carrier
KY997_21725	COG0281	malic enzyme
KY997_21730	COG1435	thymidine kinase activity
KY997_21735	COG0254	rRNA binding
KY997_21740	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KY997_21745	COG1494	fructose-1,6-bisphosphatase
KY997_21750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KY997_21755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KY997_21760	COG0191	fructose-bisphosphate aldolase activity
KY997_21765	COG2204	response regulator
KY997_21770	COG4821	SIS domain
KY997_21775	COG0504	CTP synthase activity
KY997_21780	COG3343	RNA polymerase activity
KY997_21800	COG1250	3-hydroxyacyl-CoA dehydrogenase
KY997_21805	COG0183	Belongs to the thiolase family
KY997_21825	COG0018	arginyl-trna synthetase
KY997_21830	COG4506	Protein conserved in bacteria
KY997_21840	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KY997_21855	COG1994	Peptidase M50
KY997_21860	COG1942	4-Oxalocrotonate Tautomerase
KY997_21930	COG1414	Transcriptional regulator
KY997_21945	COG3253	May function as heme-dependent peroxidase
KY997_21955	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KY997_21975	COG1131	(ABC) transporter
KY997_21990	COG2363	Small membrane protein
KY997_21995	COG2233	PERMEase
KY997_22010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
KY997_22020	COG0351	phosphomethylpyrimidine kinase
KY997_22030	COG1621	beta-fructofuranosidase activity
KY997_22040	COG3711	transcriptional antiterminator
KY997_22050	COG1404	Belongs to the peptidase S8 family
KY997_22060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KY997_22070	COG0778	Nitroreductase
KY997_22080	COG0772	Belongs to the SEDS family
KY997_22085	COG0772	Belongs to the SEDS family
KY997_22090	COG3314	Sporulation integral membrane protein YlbJ
KY997_22110	COG0456	acetyltransferase
KY997_22145	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KY997_22155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KY997_22160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KY997_22165	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KY997_22175	COG0655	NAD(P)H dehydrogenase (quinone) activity
KY997_22180	COG3162	membrane
KY997_22185	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KY997_22200	COG1940	carbohydrate kinase activity
KY997_22205	COG0352	thiamine-phosphate diphosphorylase activity
KY997_22210	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
KY997_22215	COG0583	DNA-binding transcription factor activity
KY997_22230	COG1380	Effector of murein hydrolase LrgA
KY997_22235	COG1346	cytolysis
KY997_22245	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KY997_22250	COG0346	lactoylglutathione lyase activity
KY997_22255	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KY997_22260	COG1442	glycosyl transferase family 8
KY997_22270	COG4585	Histidine kinase
KY997_22275	COG2197	response regulator
KY997_22280	COG2409	Drug exporters of the RND superfamily
KY997_22285	COG5522	Integral membrane protein (intg_mem_TP0381)
KY997_22300	COG0800	Aldolase
KY997_22335	COG2357	RelA SpoT domain protein
KY997_22350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KY997_22355	COG1696	Membrane protein involved in D-alanine export
KY997_22360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KY997_22365	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KY997_22370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KY997_22375	COG2814	Major facilitator Superfamily
KY997_22385	COG1447	Phosphotransferase system cellobiose-specific component IIA
KY997_22395	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_22400	COG3711	transcriptional antiterminator
KY997_22400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KY997_22405	COG2094	Belongs to the DNA glycosylase MPG family
KY997_22415	COG0372	Belongs to the citrate synthase family
KY997_22425	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KY997_22445	COG2755	lipolytic protein G-D-S-L family
KY997_22460	COG2814	Major facilitator Superfamily
KY997_22465	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KY997_22470	COG1131	(ABC) transporter
KY997_22490	COG1595	DNA-templated transcription, initiation
KY997_22510	COG0753	catalase activity
KY997_22515	COG0735	belongs to the Fur family
KY997_22520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KY997_22530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KY997_22535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KY997_22550	COG1271	oxidase subunit
KY997_22555	COG2116	formate transmembrane transporter activity
KY997_22565	COG0281	malic enzyme
KY997_22570	COG1757	Na H antiporter
KY997_22575	COG1027	Aspartate ammonia-lyase
KY997_22585	COG1396	sequence-specific DNA binding
KY997_22590	COG2706	6-phosphogluconolactonase activity
KY997_22605	COG0726	polysaccharide deacetylase
KY997_22625	COG1215	transferase activity, transferring glycosyl groups
KY997_22630	COG3493	citrate carrier protein
KY997_22635	COG0584	glycerophosphoryl diester phosphodiesterase
KY997_22660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KY997_22695	COG2723	6-phospho-beta-galactosidase activity
KY997_22700	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KY997_22710	COG1595	DNA-templated transcription, initiation
KY997_22720	COG2195	Cleaves the N-terminal amino acid of tripeptides
KY997_22735	COG0395	ABC-type sugar transport system, permease component
KY997_22765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KY997_22825	COG1263	PTS System
KY997_22825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_22825	COG2190	(PTS) system
KY997_22830	COG3711	transcriptional antiterminator
KY997_22840	COG1122	ATPase activity
KY997_22845	COG4721	ABC-type cobalt transport system, permease component
KY997_22850	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KY997_22860	COG2224	Isocitrate lyase
KY997_22880	COG0577	efflux transmembrane transporter activity
KY997_22885	COG1136	(ABC) transporter
KY997_22890	COG2205	protein histidine kinase activity
KY997_22900	COG2723	6-phospho-beta-galactosidase activity
KY997_22905	COG1263	PTS System
KY997_22905	COG2190	(PTS) system
KY997_22905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KY997_22915	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KY997_22925	COG0513	Belongs to the DEAD box helicase family
KY997_22955	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KY997_22965	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KY997_22970	COG2390	Transcriptional regulator
KY997_22975	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KY997_22980	COG3706	GGDEF domain
KY997_22985	COG5298	Protein conserved in bacteria
KY997_22990	COG1215	transferase activity, transferring glycosyl groups
KY997_23000	COG3977	Valine--pyruvate aminotransferase
KY997_23015	COG1181	Belongs to the D-alanine--D-alanine ligase family
KY997_23025	COG0191	fructose-bisphosphate aldolase activity
KY997_23030	COG1082	Xylose isomerase domain protein TIM barrel
KY997_23035	COG1082	Xylose isomerase domain protein TIM barrel
KY997_23040	COG0673	inositol 2-dehydrogenase activity
KY997_23050	COG1082	Xylose isomerase domain protein TIM barrel
KY997_23055	COG3962	Belongs to the TPP enzyme family
KY997_23065	COG3718	enzyme involved in inositol metabolism
KY997_23080	COG0667	Aldo Keto reductase
KY997_23085	COG0584	glycerophosphoryl diester phosphodiesterase
KY997_23090	COG2271	Major facilitator Superfamily
KY997_23100	COG0488	(ABC) transporter
KY997_23105	COG0561	phosphatase activity
KY997_23155	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
KY997_23160	COG0577	efflux transmembrane transporter activity
KY997_23165	COG1136	(ABC) transporter
KY997_23170	COG2205	protein histidine kinase activity
KY997_23175	COG0745	RESPONSE REGULATOR receiver
KY997_23185	COG0840	transmembrane signaling receptor activity
KY997_23185	COG5278	phosphoserine phosphatase activity
KY997_23200	COG3867	Arabinogalactan endo-beta-1,4-galactanase
KY997_23205	COG1874	Beta-galactosidase
KY997_23210	COG3833	ABC-type maltose transport systems, permease component
KY997_23215	COG1175	transmembrane transport
KY997_23220	COG2182	Extracellular solute-binding protein
KY997_23230	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KY997_23240	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KY997_23245	COG1940	carbohydrate kinase activity
KY997_23285	COG1012	belongs to the aldehyde dehydrogenase family
KY997_23285	COG1454	alcohol dehydrogenase
KY997_23290	COG0450	alkyl hydroperoxide reductase
KY997_23295	COG3634	alkyl hydroperoxide reductase activity
KY997_23320	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KY997_23330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KY997_23335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KY997_23340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily