locus-tag class description GH772_00035 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GH772_00045 ENOG4105VN1 Heat shock protein GH772_00110 ENOG4105EKQ RNA-directed DNA polymerase GH772_00125 ENOG4105CIG ABC transporter GH772_00185 ENOG4108M1A Chitin-binding protein GH772_00200 ENOG4105C8Q Methyl-accepting chemotaxis GH772_00205 ENOG4107SDU Methyl-accepting chemotaxis GH772_00225 ENOG4105K4H Nlp p60 protein GH772_00235 ENOG41080HT Transcriptional regulator, arsr family GH772_00345 ENOG4105EKQ RNA-directed DNA polymerase GH772_00400 ENOG4105EKQ RNA-directed DNA polymerase GH772_00405 ENOG4107QZI cell division protein FtsK GH772_00435 ENOG4105D7V transposase GH772_00530 ENOG4105D7V transposase GH772_00630 ENOG41067XF inhibitor GH772_00685 ENOG4105EKQ RNA-directed DNA polymerase GH772_00740 ENOG4105DHF Membrane GH772_00760 ENOG4105K70 DNA-binding protein GH772_00775 ENOG4105KRN Transcriptional regulator, abrb family GH772_00785 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH772_00810 ENOG4108IBT Inherit from COG: transposase GH772_00850 ENOG41086D8 Transcriptional regulator GH772_00875 ENOG4105K59 histidine triad (HIT) protein GH772_00930 ENOG4105VMP Transcriptional regulator GH772_00945 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GH772_00970 ENOG41090VF Stage v sporulation protein ac GH772_00975 ENOG4105CZ3 stage V sporulation protein ad GH772_00990 ENOG4108QY0 Membrane GH772_00995 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GH772_01010 ENOG4108B31 Spore germination protein GH772_01015 ENOG4105E1K spore germination protein GH772_01030 ENOG4105KVH Transcriptional regulator GH772_01040 ENOG4105C4W S-formylglutathione hydrolase GH772_01050 ENOG4105D9M gamma-glutamylcysteine synthetase GH772_01065 ENOG4108NHD germination protein GH772_01075 ENOG4108W2Y isochorismatase GH772_01085 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_01090 ENOG4105BZU Histidine kinase GH772_01130 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GH772_01265 ENOG4105SX7 Transporter GH772_01295 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH772_01315 ENOG4108SHN Glycosyl transferase, family 2 GH772_01335 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH772_01365 ENOG4107ZXU DSBA oxidoreductase GH772_01390 ENOG4105BZU Histidine kinase GH772_01400 ENOG4105C7N Xanthine uracil vitamin C permease GH772_01420 ENOG4108TYN CAAX amino terminal protease family protein GH772_01435 ENOG4105C5H ABC transporter GH772_01445 ENOG410801F ribosomal-protein-alanine acetyltransferase GH772_01450 ENOG41072GX Peptidase M22 Glycoprotease GH772_01455 ENOG4105K8N protein family UPF0079, ATPase GH772_01555 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GH772_01565 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GH772_01570 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GH772_01595 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GH772_01600 ENOG4105CPF Cell wall formation (By similarity) GH772_01605 ENOG4108SC4 )-transporter GH772_01610 ENOG4105CUB amino acid GH772_01620 ENOG4105ERH Fumarylacetoacetate hydrolase GH772_01625 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase GH772_01655 ENOG410667J hydrolase GH772_01660 ENOG4108JQ7 (ABC) transporter GH772_01665 ENOG4105C3U ABC transporter GH772_01670 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH772_01680 ENOG4105DEF Extracellular solute-binding protein, family 5 GH772_01685 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein GH772_01695 ENOG4105C5H ABC transporter GH772_01715 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GH772_01720 ENOG4108RE7 deoxyribonuclease GH772_01730 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GH772_01750 ENOG4105F6E Acyl-transferase GH772_01780 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GH772_01785 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GH772_01790 ENOG4105E0C molybdate abc transporter GH772_01800 ENOG4107XDY Nicotinamide Mononucleotide Transporter GH772_01815 ENOG4108J59 Extracellular solute-binding protein, family 5 GH772_01820 ENOG4108J59 Extracellular solute-binding protein, family 5 GH772_01840 ENOG4108JQ7 (ABC) transporter GH772_01845 ENOG4105C3U ABC transporter GH772_01850 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH772_01855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH772_01870 ENOG4105C2C drug resistance transporter, Bcr CflA GH772_01885 ENOG4105IQ5 FAD linked oxidase domain protein GH772_01895 ENOG4105EE1 crotonyl-CoA reductase GH772_01900 ENOG4105D01 (LipO)protein GH772_01910 ENOG4108UMI ABC transporter, permease GH772_01915 ENOG4108PSK reductase GH772_01955 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GH772_01965 ENOG4105CMG Carbohydrate kinase GH772_01975 ENOG4108VQT Alpha beta hydrolase fold protein GH772_01995 ENOG4107U5W ybbr family GH772_02000 ENOG4105C8B TIGR00159 family GH772_02080 ENOG4108NMV polysaccharide deacetylase GH772_02095 ENOG4105D1F ATP-binding protein GH772_02125 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GH772_02130 ENOG4108JJB ABC transporter GH772_02160 ENOG41067V7 50S ribosomal protein L36 GH772_02170 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GH772_02180 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GH772_02205 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GH772_02310 ENOG4105XPM ribosomal protein GH772_02325 ENOG4107Y49 methyltransferase GH772_02350 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GH772_02365 ENOG4105QIV RNA polymerase GH772_02370 ENOG4105M0M Tetracycline resistance protein GH772_02375 ENOG4105C2N RNA methyltransferase TrmH family group 3 GH772_02390 ENOG4105D7W serine acetyltransferase GH772_02410 ENOG4105CTP PilT protein domain protein GH772_02420 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GH772_02435 ENOG4108Z0C Uvrb UvrC protein GH772_02525 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GH772_02535 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GH772_02540 ENOG4105KRF dihydroneopterin aldolase GH772_02545 ENOG4105EEI dihydropteroate synthase GH772_02550 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GH772_02555 ENOG4105DDQ anthranilate synthase GH772_02560 ENOG4105CRQ synthase (Component I) GH772_02565 ENOG4105C6T cysteine synthase GH772_02580 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GH772_02585 ENOG4108UGV hypoxanthine phosphoribosyltransferase GH772_02610 ENOG41060GV RNA binding s1 domain protein GH772_02625 ENOG4105VYY sporulation protein yabp GH772_02630 ENOG41082I2 s4 domain protein GH772_02635 ENOG4108IY2 MazG family GH772_02645 ENOG4108M14 stage v sporulation protein t GH772_02650 ENOG4108JA2 transcriptioN-repair coupling factor GH772_02665 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GH772_02680 ENOG4105KME endoribonuclease L-psp GH772_02685 ENOG4105DFT pur operon repressor GH772_02700 ENOG4105W42 Veg protein GH772_02705 ENOG4105XFA sporulation peptidase YabG GH772_02715 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) GH772_02720 ENOG4105F8V Hydrolase, tatD family GH772_02730 ENOG4105KRN Transcriptional regulator, abrb family GH772_02735 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GH772_02745 ENOG41060K3 Methyltransferase GH772_02755 ENOG4105MA4 psp1 domain protein GH772_02760 ENOG4105FA2 dna polymerase iii GH772_02770 ENOG4105CXN decarboxylase GH772_02805 ENOG41067KS pro-sigma K processing GH772_02825 ENOG4105C6E dna polymerase iii GH772_02835 ENOG4108Z6B deaminase GH772_02840 ENOG4105GTG Isochorismatase GH772_02850 ENOG4105ZMH deoxynucleoside kinase GH772_02885 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GH772_02920 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH772_02935 ENOG410848D S4 domain protein YaaA GH772_02940 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GH772_02960 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GH772_02990 ENOG4107QJE Chromosome Partitioning Protein GH772_02995 ENOG4105FA0 parb-like partition protein GH772_03000 ENOG4108ZDA Sporulation protein YyaC GH772_03005 ENOG4105D8X mechanosensitive ion channel GH772_03010 ENOG4105VDK protein, conserved in bacteria GH772_03015 ENOG4105C3G gtp-binding protein GH772_03025 ENOG4108UUM single-stranded DNA-binding protein GH772_03035 ENOG4108XMW Membrane GH772_03040 ENOG4105BZR domain protein GH772_03050 ENOG4105CDU Replicative dna helicase GH772_03080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_03085 ENOG4105BZU Histidine kinase GH772_03100 ENOG4105Q2H domain protein GH772_03105 ENOG4105C0H protease GH772_03155 ENOG4107Y5K Resolvase GH772_03165 ENOG4105DPN Oligoendopeptidase f GH772_03175 ENOG4105C1J atp-dependent rna helicase GH772_03185 ENOG4108UT2 hemolysin iii GH772_03190 ENOG4105CMR udp-glucose 4-epimerase GH772_03225 ENOG4105IW1 AmiS UreI transporter GH772_03235 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH772_03250 ENOG4107RGD Major Facilitator superfamily GH772_03255 ENOG4108HRK Histidine kinase GH772_03260 ENOG4105DY9 regulatoR GH772_03275 ENOG4106F5Q Membrane GH772_03280 ENOG4105E0X reductase GH772_03290 ENOG41067SE Tetr family transcriptional regulator GH772_03295 ENOG4105C5H ABC transporter GH772_03310 ENOG4105K64 Glycosyl transferase, family 2 GH772_03325 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) GH772_03330 ENOG4108S4H thioesterase Superfamily protein GH772_03340 ENOG4106YBV Methyl-accepting chemotaxis GH772_03345 ENOG4105EN6 Membrane GH772_03355 ENOG4105CG5 Glycosyl transferase (Group 1 GH772_03365 ENOG41079KZ Major Facilitator Superfamily GH772_03370 ENOG4105DY9 regulatoR GH772_03375 ENOG4105D22 carbon starvation protein GH772_03380 ENOG4105VCD cytoplasmic protein GH772_03385 ENOG4105BZU Histidine kinase GH772_03390 ENOG4105DWF phosphomethylpyrimidine kinase GH772_03395 ENOG4105BZU Histidine kinase GH772_03400 ENOG4105WH1 Two component transcriptional regulator luxr family GH772_03410 ENOG4108Y4K DNA-binding transcriptional activator GH772_03435 ENOG4105D6E homoserine dehydrogenase GH772_03450 ENOG41090WU lipolytic protein G-D-S-L family GH772_03455 ENOG4105CJ1 ABC, transporter GH772_03460 ENOG4108TU7 Inherit from COG: (ABC) transporter GH772_03470 ENOG4105VCH membrane GH772_03475 ENOG410667J hydrolase GH772_03485 ENOG4107SVH Potassium channel protein GH772_03505 ENOG4108VKI Cell wall hydrolase GH772_03520 ENOG4108IJ2 phosphate acetyltransferase GH772_03535 ENOG4108VCI transcription factor, rsfa family GH772_03545 ENOG4105DQ5 transport system permease protein GH772_03550 ENOG4105EHG Permease protein GH772_03555 ENOG4105E0A ABC, transporter GH772_03560 ENOG4108V5C ABC transporter GH772_03565 ENOG4105DCI Phosphohydrolase GH772_03570 ENOG41069HH 4-oxalocrotonate tautomerase GH772_03575 ENOG4108Z4T Peptidase M50 GH772_03580 ENOG4108XFG YwhD family GH772_03585 ENOG4105BZ4 penicillin-binding protein GH772_03590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GH772_03595 ENOG4107SWG transcriptional regulator MERR family GH772_03600 ENOG4105DXB Major Facilitator superfamily GH772_03610 ENOG4105CYW agmatinase GH772_03630 ENOG410684U Domain of unknown function (DUF1934) GH772_03640 ENOG4105EMN RNA polymerase sigma factor GH772_03660 ENOG4105IIU Aminopeptidase GH772_03670 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GH772_03675 ENOG4108M15 ABC transporter GH772_03680 ENOG4105KCT ABC transporter GH772_03685 ENOG4105BZU Histidine kinase GH772_03710 ENOG4105BZU Histidine kinase GH772_03725 ENOG4105DF6 Fe-S oxidoreductase GH772_03735 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GH772_03740 ENOG4105C1G acyl-Coa dehydrogenase GH772_03745 ENOG4105C1G acyl-Coa dehydrogenase GH772_03780 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GH772_03785 ENOG4105CBT Fructose-1,6-bisphosphatase GH772_03790 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GH772_03805 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GH772_03810 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GH772_03815 ENOG4108ZXQ stage ii sporulation protein r GH772_03825 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GH772_03840 ENOG4107XC4 flavin reductase domain protein, FMN-binding GH772_03845 ENOG4108VGI doxx family GH772_03860 ENOG4108YZG isomerase GH772_03890 ENOG41062M3 atp synthase GH772_03895 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) GH772_03945 ENOG4105BZU Histidine kinase GH772_03950 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GH772_03960 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain GH772_03990 ENOG4105D65 subunit l GH772_03995 ENOG4105C8S subunit m GH772_04000 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) GH772_04005 ENOG4106778 Protein of unknown function (DUF1146) GH772_04025 ENOG4105DY9 regulatoR GH772_04040 ENOG4105FRN stage II sporulation protein GH772_04050 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GH772_04065 ENOG4108QV3 biosynthesis protein GH772_04070 ENOG4105HTX biosynthesis protein GH772_04075 ENOG4107YJ4 chain length determinant protein GH772_04080 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GH772_04085 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GH772_04095 ENOG4105D3Q Sugar transferase GH772_04100 ENOG4105CMR udp-glucose 4-epimerase GH772_04110 ENOG4105C5E polysaccharide biosynthesis protein GH772_04120 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GH772_04130 ENOG4105CG5 Glycosyl transferase (Group 1 GH772_04140 ENOG4107QRS glycosyltransferase group 2 family protein GH772_04145 ENOG4105CMR udp-glucose 4-epimerase GH772_04150 ENOG4108KGH TRANSCRIPTIONal GH772_04160 ENOG4105CMR udp-glucose 4-epimerase GH772_04165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_04170 ENOG41062D9 Histidine kinase GH772_04185 ENOG4105CXY transporter GH772_04195 ENOG4105C19 ABC transporter GH772_04200 ENOG4107RBB ABC transporter, permease GH772_04210 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_04240 ENOG4105C0D helicase GH772_04245 ENOG4105KBK Zinc finger, swim domain protein GH772_04270 ENOG41069ER domain protein GH772_04275 ENOG4105C94 Transporter GH772_04280 ENOG4107R8N Glycosyl transferase, family 2 GH772_04305 ENOG4105E0M Sulfatase GH772_04315 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) GH772_04325 ENOG4105DAA L-lactate GH772_04355 ENOG4107RSM transcriptional regulator GH772_04380 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GH772_04395 ENOG4105VZJ PTS System GH772_04405 ENOG4105VCP PTS System GH772_04425 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GH772_04435 ENOG4105CK1 PTS System GH772_04440 ENOG4105VCP PTS System GH772_04445 ENOG4105F8D glycoside hydrolase family 4 GH772_04465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GH772_04475 ENOG4105ESV Glycosyl transferase, family 4 GH772_04480 ENOG4105C6Y Udp-glucose 6-dehydrogenase GH772_04485 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GH772_04490 ENOG4108KGH TRANSCRIPTIONal GH772_04495 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GH772_04505 ENOG4105KVH Transcriptional regulator GH772_04510 ENOG4105K4H Nlp p60 protein GH772_04520 ENOG41081UC Inherit from COG: Competence protein GH772_04525 ENOG4105VEQ Cold shock protein GH772_04530 ENOG4105MS2 ribosomal subunit Interface protein GH772_04550 ENOG4105CAK Cell division ATP-binding protein ftsE GH772_04555 ENOG4105CRP Part of the ABC transporter FtsEX involved in GH772_04560 ENOG4105CN1 protease GH772_04570 ENOG4105BZ1 (ABC) transporter GH772_04580 ENOG4105C5H ABC transporter GH772_04585 ENOG4108WS4 fmn reductase GH772_04595 ENOG4105DUM transcriptional regulator, lysR family GH772_04630 ENOG4107TXC Transcriptional regulator GH772_04645 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GH772_04655 ENOG41086DT Membrane protein of unknown function GH772_04675 ENOG4108S4C acetyltransferase GH772_04685 ENOG4105C3M thioredoxin reductase GH772_04695 ENOG4108Z4K mutator MutT protein GH772_04705 ENOG4105CHW UPF0052 protein GH772_04715 ENOG4105KRI phosphocarrier protein (HPr GH772_04720 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GH772_04725 ENOG4108QY0 Membrane GH772_04740 ENOG4105CZ3 stage V sporulation protein ad GH772_04745 ENOG41090VF Stage v sporulation protein ac GH772_04760 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH772_04780 ENOG4107QMH DNA methylase GH772_04825 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_04875 ENOG41067MG lrgb family GH772_04880 ENOG4105XZU Preprotein translocase, subunit SecG GH772_04890 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GH772_04910 ENOG4105DHF Membrane GH772_04915 ENOG4108ZHR arsR family transcriptional regulator GH772_04925 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_04930 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GH772_04945 ENOG41086D8 Transcriptional regulator GH772_04950 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GH772_04995 ENOG4107ZTW SNARE associated Golgi GH772_05015 ENOG4105C19 ABC transporter GH772_05040 ENOG4105CM4 permease protein GH772_05045 ENOG4108IPW abc transporter atp-binding protein GH772_05055 ENOG4108VY7 phosphate-starvation-inducible protein PsiE GH772_05060 ENOG4108MK9 spermidine N(1)-acetyltransferase GH772_05065 ENOG4105C5H ABC transporter GH772_05090 ENOG4105WMR Protein CrcB homolog GH772_05100 ENOG4105C8Q Methyl-accepting chemotaxis GH772_05125 ENOG4105D4A Cell wall formation (By similarity) GH772_05130 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GH772_05145 ENOG4105KVH Transcriptional regulator GH772_05150 ENOG4105F27 Major Facilitator GH772_05155 ENOG4105CV8 reductase GH772_05175 ENOG4108RYK Nad-dependent epimerase dehydratase GH772_05190 ENOG4105D9N nucleoside GH772_05195 ENOG4105D9N nucleoside GH772_05215 ENOG4108URH decarboxylase GH772_05235 ENOG4108RMU ferritin dps family protein GH772_05245 ENOG4105NCW Trka-c domain protein GH772_05250 ENOG4107S91 Sodium hydrogen exchanger GH772_05270 ENOG4105D4Y metalloprotease GH772_05275 ENOG4105VG1 fes assembly suf system protein GH772_05280 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GH772_05285 ENOG4105C8Q Methyl-accepting chemotaxis GH772_05310 ENOG4105BZU Histidine kinase GH772_05315 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_05320 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH772_05330 ENOG4107ZTW SNARE associated Golgi GH772_05365 ENOG4107AYK membrAne GH772_05375 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins GH772_05400 ENOG4107R7I amino acid GH772_05410 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) GH772_05415 ENOG4105F27 Major Facilitator GH772_05430 ENOG4105D7V transposase GH772_05435 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GH772_05455 ENOG4105DZ1 carboxypeptidase GH772_05470 ENOG4105CHU acetyl-coa acetyltransferase GH772_05480 ENOG4105C1G acyl-Coa dehydrogenase GH772_05485 ENOG4108W8B Beta-lactamase domain protein GH772_05555 ENOG41080E8 Transcriptional regulator, Spx MgsR family GH772_05585 ENOG4108UMI ABC transporter, permease GH772_05590 ENOG4105D01 (LipO)protein GH772_05595 ENOG4105D01 (LipO)protein GH772_05600 ENOG4105C3K feS assembly ATPase SufC GH772_05605 ENOG4105JRK feS assembly protein SufD GH772_05610 ENOG4105C9B Cysteine desulfurase GH772_05615 ENOG4108UNV SUF system FeS assembly protein, NifU family GH772_05620 ENOG4105DIW FeS assembly protein SUFB GH772_05625 ENOG4107R8B 5'-nucleotidase GH772_05630 ENOG4105KZD Domain of unknown function (DUF1805) GH772_05640 ENOG4105FAA peptidase M23 GH772_05665 ENOG41090T1 Membrane GH772_05670 ENOG4107TXC Transcriptional regulator GH772_05675 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GH772_05680 ENOG4105MMD transcriptional regulator GH772_05695 ENOG4105CBT Fructose-1,6-bisphosphatase GH772_05710 ENOG4105D4U had-superfamily hydrolase, subfamily iia GH772_05715 ENOG4105DYS nad(p)h dehydrogenase (quinone) GH772_05725 ENOG4108W5N phosphatidylglycerophosphatase a GH772_05740 ENOG41083MR nifu domain-containing protein GH772_05785 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA GH772_05790 ENOG4105C4B ABC transporter, permease GH772_05795 ENOG4108JJA ABC, transporter GH772_05820 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GH772_05840 ENOG4105EWC Purine nucleoside phosphorylase GH772_05865 ENOG4105CEP NADH dehydrogenase GH772_05880 ENOG41069ER domain protein GH772_05900 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GH772_05920 ENOG4105KA0 thioesterase Superfamily protein GH772_05925 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) GH772_05940 ENOG4107R3E Citrate transporter GH772_05950 ENOG4105Y38 Kinase-associated protein B GH772_05960 ENOG4105C87 Aminotransferase class I and II GH772_05970 ENOG4108MUZ hydrolase GH772_05975 ENOG4105C5I Dehydrogenase GH772_05980 ENOG4108ZB6 transcriptional regulator AsnC family GH772_05985 ENOG4105CHM Aminotransferase GH772_05995 ENOG4105WG9 Conserved Protein GH772_06010 ENOG4107PBV potassium channel GH772_06015 ENOG4105KT7 mgtC SapB transporter GH772_06050 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GH772_06150 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GH772_06200 ENOG4105VEQ Cold shock protein GH772_06210 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GH772_06215 ENOG4105E4F Isochorismate synthase GH772_06225 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GH772_06230 ENOG4108IPT Naphthoate synthase GH772_06240 ENOG4105DTQ mandelate racemase muconate lactonizing GH772_06260 ENOG41069H0 dihydroorotase EC 3.5.2.3 GH772_06280 ENOG4105FDP GntR family transcriptional regulator GH772_06285 ENOG4105C6Z Gluconate GH772_06335 ENOG41082BM Transcriptional regulator, arsr family GH772_06345 ENOG41086D8 Transcriptional regulator GH772_06350 ENOG4105C19 ABC transporter GH772_06375 ENOG4107ZTW SNARE associated Golgi GH772_06390 ENOG4105C19 ABC transporter GH772_06415 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GH772_06420 ENOG4108UGV hypoxanthine phosphoribosyltransferase GH772_06450 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_06455 ENOG4105BZU Histidine kinase GH772_06490 ENOG41087YS Phage shock protein A GH772_06535 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH772_06540 ENOG4105C4M (Ubiquinol oxidase) subunit I GH772_06545 ENOG4108V2W Carbonate dehydratase GH772_06600 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GH772_06610 ENOG4105D2X ABC transporter substrate-binding protein GH772_06630 ENOG4107T7U Sulfatase GH772_06635 ENOG4107S9D Alpha beta hydrolase GH772_06640 ENOG4105BZU Histidine kinase GH772_06645 ENOG4105BZU Histidine kinase GH772_06690 ENOG4108MK9 spermidine N(1)-acetyltransferase GH772_06700 ENOG4108RIR Molybdenum cofactor biosynthesis protein GH772_06710 ENOG4105BZF Glycosyl transferase (Group 1 GH772_06715 ENOG4105YVM Phosphoesterase, PA-phosphatase related GH772_06720 ENOG4108Z0R Transferase GH772_06725 ENOG4105E8V Alpha Beta Hydrolase Fold protein GH772_06760 ENOG4105CIG ABC transporter GH772_06770 ENOG4105N5T Radical SAM Protein GH772_06790 ENOG4105C19 ABC transporter GH772_06805 ENOG4105NCW Trka-c domain protein GH772_06810 ENOG4107S91 Sodium hydrogen exchanger GH772_06815 ENOG410605W Major Facilitator GH772_06845 ENOG4108B31 Spore germination protein GH772_06855 ENOG4105DWV Homoserine O-trans-acetylase GH772_06865 ENOG41085GJ domain protein GH772_06885 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GH772_06890 ENOG4105D06 uba thif-type nad fad binding protein GH772_06900 ENOG4105CVM Molybdenum cofactor synthesis domain protein GH772_06905 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GH772_06910 ENOG4108ZAF Molybdopterin GH772_06930 ENOG4107EXU Short-chain dehydrogenase reductase Sdr GH772_06935 ENOG4108VJ1 Transcriptional regulator (CarD family GH772_06970 ENOG4105CBX hi0933 family GH772_06985 ENOG4105YW5 deoR family transcriptional regulator GH772_06990 ENOG4107QSE Dipeptidase GH772_07000 ENOG4108IUM Glycogen debranching enzyme GH772_07005 ENOG4108V15 phosphotransferase enzyme family GH772_07020 ENOG4105C8F Beta-lactamase domain protein GH772_07050 ENOG4108VDD TRNA binding domain protein GH772_07095 ENOG4105C88 aminopeptidase GH772_07115 ENOG4105ETE Transcriptional regulator (LacI family GH772_07145 ENOG4105EP9 oxidoreductase GH772_07155 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH772_07170 ENOG4105DGU Histone deacetylase GH772_07175 ENOG4105W87 Cbs domain GH772_07180 ENOG4105F1V Acetoin utilization protein GH772_07200 ENOG4105EMN RNA polymerase sigma factor GH772_07230 ENOG4105C28 cystathionine GH772_07240 ENOG4105U5Y Transcriptional regulator GH772_07250 ENOG4105C5Q Transcriptional regulator GH772_07275 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH772_07285 ENOG4105EFZ amidohydrolase GH772_07300 ENOG4105KBJ sporulation protein ytfj GH772_07305 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GH772_07335 ENOG4108JYZ YitT family GH772_07395 ENOG4107YZX Universal stress protein GH772_07415 ENOG41082W1 Cupin 2, conserved barrel domain protein GH772_07420 ENOG4105Z7P Acetyltransferase (GNAT) family GH772_07455 ENOG4105DC7 peptidase M24 GH772_07490 ENOG4105SFS phosphoesterase RecJ domain protein GH772_07500 ENOG4105VV2 GH772_07505 ENOG4105C0B DNA polymerase III (alpha subunit) GH772_07510 ENOG4105C6K Malic enzyme GH772_07515 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GH772_07540 ENOG4105FS0 cytoplasmic membrane protein GH772_07545 ENOG4108REF Sporulation integral membrane protein ytvi GH772_07555 ENOG4105BZN citrate synthase GH772_07560 ENOG4108HMX isocitrate dehydrogenase (NADP) GH772_07580 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH772_07585 ENOG4105BZU Histidine kinase GH772_07590 ENOG4105C2M dna polymerase I GH772_07605 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GH772_07610 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GH772_07620 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GH772_07640 ENOG4108TDW sporulation protein YtxC GH772_07645 ENOG4105C22 threonyL-tRNA synthetase GH772_07650 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GH772_07670 ENOG4105CN9 Peptidase m42 family protein GH772_07675 ENOG4108JGH Tetr family transcriptional regulator GH772_07680 ENOG4105CW7 secretion protein, HlyD family GH772_07685 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_07705 ENOG4108RWN rrna methyltransferase GH772_07755 ENOG4105DCG PHP domain protein GH772_07765 ENOG4105FE9 pseudouridine synthase GH772_07775 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) GH772_07780 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) GH772_07795 ENOG4105E0A ABC, transporter GH772_07800 ENOG4105KFN sortase, SrtB family GH772_07815 ENOG4105DR4 Methyltransferase GH772_07825 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH772_07865 ENOG4105CEY Amp-dependent synthetase and ligase GH772_07870 ENOG4107Z3H Transcriptional regulator, TetR family GH772_07875 ENOG41060WC Enoyl-CoA hydratase GH772_07880 ENOG4105BZJ Electron transfer flavoprotein GH772_07885 ENOG4105C10 Electron transfer flavoprotein GH772_07890 ENOG4105K63 Thioredoxin GH772_07905 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GH772_07915 ENOG4105E33 succinate dehydrogenase GH772_07925 ENOG4108VXD carboxy-peptidase GH772_07930 ENOG4105E14 MotA TolQ exbB proton channel GH772_07935 ENOG4105ER2 Ompa motb domain protein GH772_07940 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family GH772_07945 ENOG4108IUX (ABC) transporter GH772_07950 ENOG4105RHA ABC transporter, permease GH772_07955 ENOG4108Z40 Transcriptional regulator GH772_07960 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) GH772_07970 ENOG4108JCI Transcriptional regulator GH772_07975 ENOG41067S9 phage shock protein C, PspC GH772_07980 ENOG4105DZC cytosine deaminase GH772_07990 ENOG4105PFC Transcriptional regulator GH772_08005 ENOG4105KBX Transcriptional regulator, TetR family GH772_08015 ENOG4108PCX Major Facilitator GH772_08025 ENOG4108XJQ germination protein GH772_08035 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GH772_08040 ENOG4105M59 Phosphodiesterase, mj0936 family GH772_08060 ENOG4108QCI YvbH-like oligomerisation region GH772_08090 ENOG4108IUQ atp-dependent protease GH772_08110 ENOG4105K56 Transcriptional regulator GH772_08135 ENOG4105D52 delta-aminolevulinic acid dehydratase GH772_08145 ENOG41068KH stage VI sporulation protein D GH772_08170 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GH772_08190 ENOG4105DFF Rod shape-determining protein mreb GH772_08195 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GH772_08210 ENOG4107QMS site-determining protein GH772_08225 ENOG4105C03 ribonuclease GH772_08235 ENOG4105X36 (ribosomal) protein GH772_08260 ENOG4105EWM Histidine kinase GH772_08280 ENOG4105CQC Prephenate dehydratase GH772_08285 ENOG4108RPX mosc domain containing protein GH772_08300 ENOG4108IYU L-aspartate oxidase GH772_08305 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GH772_08345 ENOG41061AI Protein of unknown function (DUF2905) GH772_08360 ENOG4105VIE preprotein translocase, subunit YajC GH772_08370 ENOG4108QG2 Membrane GH772_08375 ENOG4105CKP Polysaccharide Biosynthesis Protein GH772_08385 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GH772_08390 ENOG41076HS cation diffusion facilitator family transporter GH772_08395 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GH772_08405 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GH772_08430 ENOG4105CUZ uba thif-type nad fad binding protein GH772_08435 ENOG4108VCI transcription factor, rsfa family GH772_08440 ENOG4105D1H recombination factor protein RarA GH772_08450 ENOG4105C3J Cysteine desulfurase GH772_08465 ENOG4105C7H Helicase, RecD TraA family GH772_08470 ENOG41060CR GH772_08485 ENOG4105C02 permease GH772_08515 ENOG4105HHA aminodeoxychorismate lyase GH772_08520 ENOG4108VQJ O-methyltransferase GH772_08525 ENOG4105XYU peptidase (U32 family) GH772_08530 ENOG4105CFP Peptidase U32 GH772_08545 ENOG4107XRG penicillin-binding protein GH772_08575 ENOG4105C28 cystathionine GH772_08580 ENOG4108EKI Dehydrogenase GH772_08590 ENOG4108HUF Transporter GH772_08595 ENOG4105S6R Iron-hydroxamate transporter permease subunit GH772_08635 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GH772_08645 ENOG4105MIR Phenylalanine 4-monooxygenase GH772_08650 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GH772_08685 ENOG4108MUZ hydrolase GH772_08690 ENOG4105KEG ribosomal-protein-alanine acetyltransferase GH772_08695 ENOG4105G6Z alkaline phosphatase GH772_08725 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_08740 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GH772_08745 ENOG4105CQW ribosome biogenesis GTPase YqeH GH772_08755 ENOG410812S Rna-binding protein GH772_08765 ENOG4108WF2 Metal Dependent Phosphohydrolase GH772_08775 ENOG4105DXX methyltransferase GH772_08785 ENOG4105KQC Competence protein GH772_08790 ENOG4108UK2 deaminase GH772_08795 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GH772_08805 ENOG4105TQK DNA polymerase iii, delta' subunit GH772_08830 ENOG4105KVH Transcriptional regulator GH772_08835 ENOG4105CSA Coproporphyrinogen iii oxidase GH772_08865 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GH772_08870 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GH772_08880 ENOG4105KTH gatB Yqey GH772_08885 ENOG41068P3 sporulation protein YqfC GH772_08895 ENOG4105C9A Phoh family GH772_08900 ENOG4105CTJ Metal Dependent Phosphohydrolase GH772_08910 ENOG4107YR5 Diacylglycerol kinase GH772_08915 ENOG4105KG3 cytidine deaminase GH772_08920 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GH772_08950 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GH772_08955 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_08970 ENOG4105EGD dinuclear metal center protein, YbgI family GH772_08995 ENOG41069ZM Protein of unknown function (DUF2624) GH772_09000 ENOG4108JYZ YitT family GH772_09005 ENOG4105FDK ABC transporter GH772_09015 ENOG4105N80 Ferric uptake regulator, Fur family GH772_09040 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH772_09050 ENOG4107RF6 penicillin-binding protein GH772_09055 ENOG4105PWN phosphate abc transporter GH772_09060 ENOG4105C8U phosphate abc transporter GH772_09065 ENOG4105E2Z phosphate ABC transporter (Permease GH772_09070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GH772_09075 ENOG4108UTW Plays a role in the regulation of phosphate uptake GH772_09090 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GH772_09100 ENOG4105DKQ ROK family GH772_09110 ENOG4105C5X domain protein GH772_09130 ENOG4105C28 cystathionine GH772_09135 ENOG4105C28 cystathionine GH772_09145 ENOG4105C3R Methionine synthase GH772_09330 ENOG410682Q Phage transcriptional regulator, ArpU GH772_09365 ENOG4105CAR Terminase, large subunit GH772_09375 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GH772_09555 ENOG4105C0D helicase GH772_09585 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GH772_09590 ENOG4105CJ1 ABC, transporter GH772_09625 ENOG41080TC multidrug resistance protein GH772_09645 ENOG4105WZW rhodanese family GH772_09650 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GH772_09690 ENOG4105CBJ Metal-dependent enzyme GH772_09705 ENOG4105DC7 peptidase M24 GH772_09730 ENOG4105CD2 stage iii sporulation protein aa GH772_09735 ENOG4105KR5 Stage iii sporulation protein GH772_09740 ENOG4108CQH stage III sporulation protein AC GH772_09745 ENOG4105KQ4 Stage iii sporulation protein ad GH772_09755 ENOG410644B Stage III sporulation protein af GH772_09780 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GH772_09785 ENOG4108ZSR alkaline shock protein GH772_09810 ENOG4105CTB Polyprenyl synthetase GH772_09820 ENOG4105DX0 Hemolysin A GH772_09830 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GH772_09835 ENOG4105S1Z Stage IV sporulation protein B GH772_09840 ENOG4107QQR Sporulation GH772_09850 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GH772_09860 ENOG4108JUB Transcriptional regulator GH772_09870 ENOG4107RDP Dehydrogenase GH772_09890 ENOG4105CPP Dehydrogenase, E1 component GH772_09895 ENOG4105C7S Dehydrogenase GH772_09905 ENOG4108QY0 Membrane GH772_09920 ENOG4108HW3 (ABC) transporter GH772_09925 ENOG4105E5Q amino acid AbC transporter GH772_09930 ENOG4105CDA abc transporter atp-binding protein GH772_09935 ENOG4108QEG Membrane GH772_09940 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GH772_09955 ENOG4105D9U N-acetyltransferase GH772_09960 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GH772_09970 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GH772_09995 ENOG4105EJQ L-serine dehydratase GH772_10000 ENOG4105II7 pyrroline-5-carboxylate reductase GH772_10005 ENOG41069FQ Metallo-beta-lactamase superfamily GH772_10010 ENOG4108IXY short-chain dehydrogenase reductase GH772_10065 ENOG4105CGH 5'-nucleotidase GH772_10070 ENOG4105DFD Na H antiporter GH772_10080 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GH772_10095 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH772_10100 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH772_10125 ENOG4108R6K riboflavin synthase, subunit alpha GH772_10130 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GH772_10150 ENOG4108YM7 Gcn5-related n-acetyltransferase GH772_10155 ENOG4105ETE Transcriptional regulator (LacI family GH772_10165 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GH772_10185 ENOG4105RHY Pfam:UPF0157 GH772_10195 ENOG4105CPC Aldo Keto reductase GH772_10215 ENOG4105MZ9 stage II sporulation protein m GH772_10220 ENOG4105I3K Ferric uptake regulator, Fur family GH772_10230 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH772_10255 ENOG4105D7N magnesium and cobalt transport protein CorA GH772_10285 ENOG4105DVE abc transporter atp-binding protein GH772_10290 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GH772_10295 ENOG4105DZ1 carboxypeptidase GH772_10300 ENOG41082AN stage II sporulation protein GH772_10310 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_10315 ENOG4105C8J )-transporter GH772_10335 ENOG41090VF Stage v sporulation protein ac GH772_10340 ENOG4105CZ3 stage V sporulation protein ad GH772_10350 ENOG4105G6R Stage v sporulation protein ae GH772_10360 ENOG4105J7I hydrolase GH772_10365 ENOG4105PTM secreted protein GH772_10370 ENOG4107ZE5 PPIases accelerate the folding of proteins GH772_10405 ENOG4105CE4 GlcNAc 6-P deacetylase GH772_10415 ENOG4105FDP GntR family transcriptional regulator GH772_10425 ENOG4105CID antiterminator GH772_10440 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GH772_10460 ENOG4106TD9 Diguanylate cyclase GH772_10470 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GH772_10510 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GH772_10515 ENOG4105EKQ RNA-directed DNA polymerase GH772_10540 ENOG4105DTD Dehydrogenase GH772_10545 ENOG4105K7K Transcriptional regulator GH772_10575 ENOG4105CHU acetyl-coa acetyltransferase GH772_10580 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) GH772_10625 ENOG4105CG3 alpha amylase, catalytic region GH772_10635 ENOG4107FKK extracellular solute-binding protein family 1 GH772_10645 ENOG4105EG2 ABC transporter, permease GH772_10650 ENOG4105FKQ transcriptional regulator GH772_10655 ENOG4105CHM Aminotransferase GH772_10665 ENOG4108HGU Histidine kinase GH772_10725 ENOG4105UIN GH772_10735 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) GH772_10750 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GH772_10755 ENOG4105EPM Diguanylate phosphodiesterase GH772_10770 ENOG4107IN1 Protein of unknown function (DUF1797) GH772_10775 ENOG4108XRC Protein of unknown function (DUF458) GH772_10810 ENOG4107ZYR domain protein GH772_10815 ENOG4105CN5 Metallo-Beta-Lactamase GH772_10825 ENOG4108X4Q Hydrolase GH772_10830 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GH772_10845 ENOG4105CPP Dehydrogenase, E1 component GH772_10895 ENOG4105CXN decarboxylase GH772_10915 ENOG4105ECY inositol monophosphatase GH772_10925 ENOG4105CI3 gtp-binding protein typa GH772_10930 ENOG4105QA2 GH772_10950 ENOG4108IAB Phoh family GH772_10965 ENOG4105CNI cell division protein FtsW GH772_10970 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GH772_11015 ENOG4105EKQ RNA-directed DNA polymerase GH772_11030 ENOG4106UY4 Inherit from COG: Scp-like extracellular GH772_11045 ENOG4107TB6 phosphoglycerate mutase GH772_11075 ENOG4106H78 methyltransferase GH772_11085 ENOG4105H20 Sporulation integral membrane protein YlbJ GH772_11090 ENOG4105D78 K07001 NTE family protein GH772_11095 ENOG41063PX domain protein GH772_11105 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) GH772_11130 ENOG4108IMY Transcriptional regulator GH772_11240 ENOG4105CAR Terminase, large subunit GH772_11250 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GH772_11375 ENOG4105KNH Nucleic acid-binding protein GH772_11410 ENOG41068DC Essential cell division protein (By similarity) GH772_11415 ENOG4105CJN penicillin-binding protein GH772_11420 ENOG4105CJN penicillin-binding protein GH772_11425 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GH772_11440 ENOG4105CNI cell division protein FtsW GH772_11455 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GH772_11460 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GH772_11465 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GH772_11475 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_11485 ENOG4105WR5 sporulation protein, YlmC YmxH family GH772_11490 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GH772_11495 ENOG4105DFA alanine racemase domain protein GH772_11505 ENOG41067XK integral membrane protein GH772_11510 ENOG4105DBK s4 domain protein GH772_11535 ENOG4105C34 Pseudouridine synthase GH772_11620 ENOG4105DC7 peptidase M24 GH772_11625 ENOG4105F23 Fibronectin-binding protein GH772_11635 ENOG4105DSJ YicC domain protein GH772_11655 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GH772_11660 ENOG4105C25 Primosomal protein n' GH772_11665 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GH772_11675 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GH772_11685 ENOG4108ZF3 Phosphatase GH772_11690 ENOG4105D9P serine threonine protein kinase GH772_11700 ENOG4105DJV ribulose-phosphate 3-epimerase GH772_11705 ENOG4105FJ0 thiamine GH772_11720 ENOG4108ZAA Alkaline-shock protein GH772_11725 ENOG4105DP4 dak2 domain fusion protein ylov GH772_11730 ENOG4105CB5 ATP-dependent DNA helicase recG GH772_11745 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GH772_11750 ENOG4105CHR reductase GH772_11765 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GH772_11770 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GH772_11790 ENOG4105VB6 UPF0109 protein GH772_11815 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GH772_11830 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GH772_11835 ENOG4105C79 DNA protecting protein DprA GH772_11840 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GH772_11850 ENOG4108HE4 integrase family GH772_11895 ENOG4105KNE Phosphatidate cytidylyltransferase GH772_11905 ENOG4105DZP Membrane-associated zinc metalloprotease GH772_11915 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GH772_11925 ENOG4105CHV Transcription elongation factor NusA GH772_11930 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GH772_11935 ENOG4105VHM ribosomal protein GH772_11945 ENOG4105W7A Protein of unknown function (DUF503) GH772_11960 ENOG4105DTN riboflavin biosynthesis protein ribF GH772_11980 ENOG4105C1V Peptidase, M16 GH772_11990 ENOG4105E35 Dipicolinate synthase subunit A GH772_11995 ENOG4108S0H Dipicolinic acid synthetase, b subunit GH772_12000 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GH772_12010 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH772_12020 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GH772_12030 ENOG4107QZI cell division protein FtsK GH772_12035 ENOG4105FDP GntR family transcriptional regulator GH772_12040 ENOG4105DIH basic membrane GH772_12045 ENOG4108JQ9 ABC transporter GH772_12050 ENOG4105UIB (ABC) transporter GH772_12070 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GH772_12075 ENOG4105XZV Protein of unknown function (DUF3243) GH772_12090 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GH772_12110 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GH772_12115 ENOG4105D48 metallophosphoesterase GH772_12120 ENOG4105MCT stage V sporulation protein S GH772_12125 ENOG4108IGT Dipeptidase GH772_12130 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein GH772_12135 ENOG4105DQU oxidoreductase, subunit beta GH772_12170 ENOG4105DA5 (ABC) transporter GH772_12195 ENOG4107QHE Choloylglycine hydrolase GH772_12205 ENOG410890F Dynamin family GH772_12210 ENOG4105E0M Sulfatase GH772_12225 ENOG4105F0V Cell wall hydrolase GH772_12270 ENOG4105BZU Histidine kinase GH772_12290 ENOG4105D03 DNA-3-methyladenine glycosylase II GH772_12295 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GH772_12325 ENOG4105E0A ABC, transporter GH772_12330 ENOG4105NIV Esterase GH772_12340 ENOG4105VPX protein, conserved in bacteria GH772_12345 ENOG410681U heavy metal transport detoxification protein GH772_12350 ENOG4105C59 p-type ATPase GH772_12360 ENOG4105K70 DNA-binding protein GH772_12365 ENOG4105TMB Formate nitrite transporter GH772_12380 ENOG4105C85 amino acid GH772_12390 ENOG4108SJC Membrane GH772_12395 ENOG4107QW4 alcohol dehydrogenase GH772_12400 ENOG4105E98 transcriptional regulator DeoR family GH772_12405 ENOG4105DE4 1-phosphofructokinase GH772_12410 ENOG4105DM4 PTS System GH772_12415 ENOG41069ER domain protein GH772_12445 ENOG4106F1P AAA ATPase, central domain protein GH772_12450 ENOG4105EN6 Membrane GH772_12455 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GH772_12460 ENOG4105CXI aluminum resistance protein GH772_12465 ENOG4105KV4 Transcriptional regulator GH772_12470 ENOG4105C5F glutamine synthetase GH772_12475 ENOG4105K7K Transcriptional regulator GH772_12495 ENOG4108SVB resolvase GH772_12505 ENOG4105CGH 5'-nucleotidase GH772_12510 ENOG4108HW3 (ABC) transporter GH772_12515 ENOG4105D5T phosphonate abc transporter GH772_12545 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GH772_12635 ENOG4105BZ1 (ABC) transporter GH772_12640 ENOG4105BZ1 (ABC) transporter GH772_12655 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GH772_12680 ENOG41067MG lrgb family GH772_12690 ENOG4107RSM transcriptional regulator GH772_12700 ENOG4105CJ1 ABC, transporter GH772_12710 ENOG4105CH2 amidohydrolase GH772_12720 ENOG4107QIV Cytochrome c biogenesis protein GH772_12735 ENOG4105EKQ RNA-directed DNA polymerase GH772_12775 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) GH772_12800 ENOG4108903 Formimidoylglutamase GH772_12805 ENOG4108VJ1 Transcriptional regulator (CarD family GH772_12810 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GH772_12815 ENOG4105CBC glutamate synthase GH772_12825 ENOG4105CK7 Sodium proline symporter GH772_12830 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GH772_12835 ENOG4105FBA Phospholipase Carboxylesterase GH772_12840 ENOG4105BZU Histidine kinase GH772_12850 ENOG4107AYK membrAne GH772_12895 ENOG4108IMY Transcriptional regulator GH772_12910 ENOG4105CEY Amp-dependent synthetase and ligase GH772_12915 ENOG4107ZYJ bioY protein GH772_12920 ENOG4107F3J Amp-dependent synthetase and ligase GH772_12950 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GH772_12975 ENOG4105E5W Transporter GH772_12975 ENOG4105E5W Transporter GH772_13005 ENOG4108I0Z Aconitate hydratase GH772_13010 ENOG4105BZ1 (ABC) transporter GH772_13020 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH772_13025 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GH772_13055 ENOG4105W8X HesB YadR YfhF-family protein GH772_13065 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase GH772_13075 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_13080 ENOG4105C0H protease GH772_13085 ENOG4105K4P CoA-binding domain protein GH772_13090 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GH772_13100 ENOG4105D9R oxidoreductase GH772_13110 ENOG4105CIG ABC transporter GH772_13125 ENOG4105EMN RNA polymerase sigma factor GH772_13135 ENOG4108KGH TRANSCRIPTIONal GH772_13140 ENOG4107QJT sodium dicarboxylate symporter GH772_13200 ENOG4105E1K spore germination protein GH772_13205 ENOG4108JB9 formate dehydrogenase GH772_13215 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GH772_13220 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GH772_13230 ENOG4105TMB Formate nitrite transporter GH772_13235 ENOG4105D06 uba thif-type nad fad binding protein GH772_13240 ENOG4105CVM Molybdenum cofactor synthesis domain protein GH772_13245 ENOG4108ZAF Molybdopterin GH772_13255 ENOG4105D1F ATP-binding protein GH772_13270 ENOG410696E Membrane GH772_13275 ENOG4105FR1 rard protein GH772_13285 ENOG4105EWU Squalene--hopene cyclase GH772_13295 ENOG4105CHR reductase GH772_13345 ENOG4108IA2 Sodium pantothenate symporter GH772_13360 ENOG4106IQC argininosuccinate lyase GH772_13370 ENOG410904N short-chain dehydrogenase reductase GH772_13390 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) GH772_13410 ENOG4105VEQ Cold shock protein GH772_13425 ENOG4108R1P GH772_13435 ENOG41073R8 VanW family GH772_13440 ENOG4108HW4 amino acid AbC transporter GH772_13450 ENOG4105EAB amino acid AbC transporter GH772_13455 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GH772_13470 ENOG4105KT7 mgtC SapB transporter GH772_13500 ENOG4105CQB FAD linked oxidase domain protein GH772_13505 ENOG4105C09 Bile acid GH772_13515 ENOG4105RHY Pfam:UPF0157 GH772_13530 ENOG4107JM4 Tetratricopeptide repeat GH772_13540 ENOG4105CIS alcohol dehydrogenase GH772_13545 ENOG41082BM Transcriptional regulator, arsr family GH772_13555 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GH772_13580 ENOG4108A04 Beta-lactamase GH772_13585 ENOG4105DPN Oligoendopeptidase f GH772_13590 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GH772_13595 ENOG4105C98 muts2 protein GH772_13615 ENOG4107V2S Transcriptional regulator GH772_13625 ENOG4107CUJ Protein of unknown function (DUF2690) GH772_13645 ENOG4105NX3 Membrane GH772_13650 ENOG4105DQ5 transport system permease protein GH772_13655 ENOG4105EHG Permease protein GH772_13660 ENOG4108MES Periplasmic binding protein GH772_13675 ENOG4107R3E Citrate transporter GH772_13685 ENOG4108TN2 lmbE family GH772_13715 ENOG4105CIS alcohol dehydrogenase GH772_13720 ENOG4105K7K Transcriptional regulator GH772_13765 ENOG4105H3G oxidoreductase GH772_13805 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) GH772_13885 ENOG4105KVH Transcriptional regulator GH772_13890 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GH772_13905 ENOG4105CHR reductase GH772_13915 ENOG4105JAB phenazine biosynthesis protein, phzf family GH772_13955 ENOG4105KVH Transcriptional regulator GH772_13960 ENOG4105KVH Transcriptional regulator GH772_13965 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GH772_13970 ENOG4105D9R oxidoreductase GH772_13975 ENOG4108TZY GntR Family Transcriptional Regulator GH772_13980 ENOG4105KVH Transcriptional regulator GH772_14010 ENOG4105EKQ RNA-directed DNA polymerase GH772_14015 ENOG4105C44 Serine transporter GH772_14030 ENOG4105F27 Major Facilitator GH772_14035 ENOG4105CV8 reductase GH772_14050 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GH772_14065 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone GH772_14070 ENOG4105CIS alcohol dehydrogenase GH772_14075 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GH772_14080 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GH772_14095 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GH772_14100 ENOG4105C6Z Gluconate GH772_14105 ENOG4105CMG Carbohydrate kinase GH772_14110 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GH772_14115 ENOG4105XDF Protein of unknown function (DUF1272) GH772_14120 ENOG4105DDN Pentapeptide repeat-containing protein GH772_14150 ENOG4105FAW cDP-glucose 4,6-dehydratase GH772_14155 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GH772_14170 ENOG4105C37 (CBS) domain GH772_14195 ENOG4105EV4 Multidrug resistance protein mdtH GH772_14205 ENOG4105DMQ Methyltransferase GH772_14240 ENOG4105C31 Tryptophanyl-tRNA synthetase GH772_14245 ENOG4108UW5 maltose o-acetyltransferase GH772_14250 ENOG4105DKQ ROK family GH772_14255 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GH772_14305 ENOG4105CJ1 ABC, transporter GH772_14315 ENOG4108PSK reductase GH772_14335 ENOG4108RCM Nitroreductase GH772_14340 ENOG4105KVH Transcriptional regulator GH772_14360 ENOG4108Z66 YbaK ebsC protein GH772_14365 ENOG4105RHY Pfam:UPF0157 GH772_14370 ENOG4105EKQ RNA-directed DNA polymerase GH772_14390 ENOG4107TXC Transcriptional regulator GH772_14430 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GH772_14465 ENOG4105DYS nad(p)h dehydrogenase (quinone) GH772_14475 ENOG4105CRW Short chain fatty acid transporter GH772_14485 ENOG4107AUC GH772_14490 ENOG4105KBX Transcriptional regulator, TetR family GH772_14495 ENOG4105KPY Small multidrug resistance protein GH772_14500 ENOG4105RXJ GH772_14510 ENOG41069JR GH772_14515 ENOG4105DA5 (ABC) transporter GH772_14530 ENOG4105CZM Major Facilitator GH772_14535 ENOG4107MII Sugar-specific transcriptional regulator TrmB GH772_14550 ENOG4108ISG Major Facilitator GH772_14590 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GH772_14610 ENOG410874W AraC family transcriptional regulator GH772_14615 ENOG41082W1 Cupin 2, conserved barrel domain protein GH772_14635 ENOG4108JQ1 Dehydrogenase GH772_14650 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GH772_14680 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GH772_14690 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GH772_14695 ENOG4108U05 Transcriptional regulator GH772_14710 ENOG4105BZU Histidine kinase GH772_14730 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) GH772_14750 ENOG4105JQZ Methyltransferase GH772_14755 ENOG4105W1Y Transcriptional regulator GH772_14770 ENOG4105C88 aminopeptidase GH772_14780 ENOG4105K6H D-cysteine desulfhydrase GH772_14840 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GH772_14855 ENOG4105N0V mono-oxygenase ydhR GH772_14895 ENOG4108YXU transcriptional regulator AsnC family GH772_14900 ENOG4105CHR reductase GH772_14905 ENOG4105M4P Tetr family transcriptional regulator GH772_14910 ENOG4105F27 Major Facilitator GH772_14915 ENOG4108IG5 Transcriptional regulator GH772_14920 ENOG4107P5I polyketide synthase GH772_14960 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) GH772_14980 ENOG4105NAE bifunctional deaminase-reductase domain protein GH772_14990 ENOG41085FC arsR family transcriptional regulator GH772_14995 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GH772_15000 ENOG4105D6J arsenicaL-resistance protein GH772_15010 ENOG4105ETE Transcriptional regulator (LacI family GH772_15015 ENOG4105NWF RbsD or FucU transport GH772_15025 ENOG4105CNN ABC, transporter GH772_15035 ENOG4107W7X Aldolase GH772_15040 ENOG4105DET Rhamnulokinase GH772_15080 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GH772_15090 ENOG4105E1K spore germination protein GH772_15105 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GH772_15110 ENOG4108TWJ NADH dehydrogenase subunit 5 GH772_15135 ENOG4105CVP deoxyribo-dipyrimidine photolyase GH772_15140 ENOG4108606 TspO/MBR family GH772_15190 ENOG4105CH6 catalase GH772_15195 ENOG4105CGH 5'-nucleotidase GH772_15200 ENOG4107QTZ amino acid GH772_15210 ENOG4107QJQ Mate efflux family protein GH772_15240 ENOG4105CSV Glutaminase GH772_15260 ENOG4108Q8B Spore germination protein GH772_15265 ENOG4108NHD germination protein GH772_15270 ENOG4105II7 pyrroline-5-carboxylate reductase GH772_15275 ENOG4105CUB amino acid GH772_15280 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GH772_15285 ENOG4105DQ6 Transposase GH772_15290 ENOG4108IMY Transcriptional regulator GH772_15295 ENOG4105HDK L-asparaginase GH772_15300 ENOG4108IJ0 Aspartate ammonia-lyase GH772_15310 ENOG4105E2A Dehydrogenase GH772_15375 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GH772_15415 ENOG4105DWD nucleoside recognition domain protein GH772_15430 ENOG4105FDT acyl-CoA dehydrogenase GH772_15435 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_15445 ENOG4108ZHR arsR family transcriptional regulator GH772_15450 ENOG4108ZRV stage ii sporulation protein p GH772_15455 ENOG4106N3A copper homeostasis protein cutc GH772_15465 ENOG4107258 Transcriptional regulator GH772_15470 ENOG4105P4J Allophanate hydrolase, subunit 1 GH772_15510 ENOG4107RF6 penicillin-binding protein GH772_15550 ENOG4105F1N DNA alkylation repair GH772_15560 ENOG4108IQI permease GH772_15565 ENOG4105KNA -acetyltransferase GH772_15570 ENOG410635A Membrane GH772_15615 ENOG4108PCN EamA-like transporter family GH772_15630 ENOG4108XET gCN5-related N-acetyltransferase GH772_15635 ENOG4108DMH HTH_ARAC GH772_15660 ENOG4105C19 ABC transporter GH772_15670 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GH772_15705 ENOG4105FS7 Transcriptional regulator GH772_15710 ENOG4108TVJ Nitroreductase GH772_15720 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GH772_15750 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GH772_15770 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GH772_15780 ENOG4105C8Y Acetylornithine aminotransferase GH772_15800 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GH772_15825 ENOG4105KNA -acetyltransferase GH772_15835 ENOG4108WCX response regulator GH772_15845 ENOG41090T1 Membrane GH772_15860 ENOG4105VMP Transcriptional regulator GH772_15870 ENOG4105G6Z alkaline phosphatase GH772_15880 ENOG4105ECK Fatty Acid Desaturase GH772_15885 ENOG4105E0Y RtcB Protein GH772_15895 ENOG4107258 Transcriptional regulator GH772_15905 ENOG4105II7 pyrroline-5-carboxylate reductase GH772_15935 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GH772_15945 ENOG41061GT Aldolase GH772_15955 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) GH772_15960 ENOG4105DKT Transcriptional regulator GH772_15970 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane GH772_15980 ENOG4105D4B ABC, transporter GH772_15995 ENOG41069ER domain protein GH772_16020 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GH772_16030 ENOG4105CIH Imidazole acetol-phosphate transaminase GH772_16050 ENOG41082JN Transcriptional regulator GH772_16055 ENOG4105EYF MMPL domain protein GH772_16065 ENOG4105C5H ABC transporter GH772_16070 ENOG4105E0M Sulfatase GH772_16075 ENOG4108ZCF integral membrane protein GH772_16085 ENOG4107VMI polysaccharide deacetylase GH772_16095 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GH772_16105 ENOG4107VC0 DNA alkylation repair enzyme GH772_16150 ENOG4108AQF aminoglycoside N(3)-acetyltransferase GH772_16195 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GH772_16200 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GH772_16205 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GH772_16215 ENOG4105C02 permease GH772_16270 ENOG4108ZMI UPF0477 protein GH772_16285 ENOG4105CHM Aminotransferase GH772_16315 ENOG41089UC methyltransferase, type 11 GH772_16330 ENOG4107BMA Transglycosylase associated protein GH772_16355 ENOG4106K7D Major facilitator family transporter GH772_16360 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GH772_16420 ENOG4105EPR degv family GH772_16430 ENOG4105DPN Oligoendopeptidase f GH772_16445 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 GH772_16465 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_16470 ENOG4105BZU Histidine kinase GH772_16475 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) GH772_16520 ENOG4105DTQ mandelate racemase muconate lactonizing GH772_16535 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) GH772_16540 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GH772_16575 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein GH772_16585 ENOG41080HI glycine oxidase GH772_16590 ENOG4105CTU Proline racemase GH772_16595 ENOG4105CTU Proline racemase GH772_16600 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GH772_16605 ENOG4105C26 Dehydrogenase GH772_16610 ENOG4105BZG amino acid carrier protein GH772_16630 ENOG4108M1A Chitin-binding protein GH772_16680 ENOG4105C9U ATP-dependent DNA helicase RecQ GH772_16700 ENOG4105EEM helicase GH772_16720 ENOG4108Z7F N-acetyltransferase GH772_16740 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GH772_16750 ENOG4105MSB protein, conserved in bacteria GH772_16755 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) GH772_16775 ENOG41087PP glycosyltransferase MGT family GH772_16780 ENOG4108M1A Chitin-binding protein GH772_16785 ENOG41082BV acetyltransferase GH772_16790 ENOG4105E66 phosphoriboisomerase A GH772_16815 ENOG4108IJ7 Glycine betaine GH772_16820 ENOG4107SQ8 Glycine betaine GH772_16855 ENOG4105DBI uridine monophosphokinase GH772_16860 ENOG4105RHY Pfam:UPF0157 GH772_16865 ENOG4105E1F short-chain dehydrogenase reductase GH772_16875 ENOG4107RUY (E1 component), alpha subunit GH772_16885 ENOG4107QKR Dehydrogenase GH772_16905 ENOG4105E98 transcriptional regulator DeoR family GH772_16920 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GH772_16950 ENOG4107Z3H Transcriptional regulator, TetR family GH772_16990 ENOG4105MSI germination protein ypeb GH772_17045 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GH772_17050 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GH772_17065 ENOG4108IUM Glycogen debranching enzyme GH772_17085 ENOG4105U0R haloacid dehalogenase-like hydrolase GH772_17110 ENOG4107VFR oxidoreductase GH772_17145 ENOG4105PKS Excinuclease abc c subunit domain protein GH772_17180 ENOG4105KWG Pfam:DUF1696 GH772_17185 ENOG4108NRW Phospholipase, patatin family GH772_17210 ENOG4108XI2 Domain of unknown function (DUF1963) GH772_17240 ENOG4108Z4K mutator MutT protein GH772_17245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GH772_17250 ENOG4105E09 nadh pyrophosphatase GH772_17265 ENOG4105FCD Major Facilitator GH772_17285 ENOG4105EGD dinuclear metal center protein, YbgI family GH772_17295 ENOG4107Y9U Membrane GH772_17320 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GH772_17380 ENOG4105CHR reductase GH772_17385 ENOG4108IG5 Transcriptional regulator GH772_17390 ENOG4105CJN penicillin-binding protein GH772_17395 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GH772_17405 ENOG4105RHY Pfam:UPF0157 GH772_17415 ENOG4108HGU Histidine kinase GH772_17450 ENOG4107RF6 penicillin-binding protein GH772_17455 ENOG4105BZU Histidine kinase GH772_17460 ENOG410667J hydrolase GH772_17535 ENOG4107EV6 Inherit from COG: YD repeat protein GH772_17615 ENOG4105ETU transcriptional activator (TenA GH772_17690 ENOG4105DK7 lysyl-tRNA synthetase GH772_17700 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GH772_17715 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GH772_17720 ENOG410900G Protein of unknown function (DUF421) GH772_17725 ENOG4105CPQ Dehydrogenase GH772_17770 ENOG41089UC methyltransferase, type 11 GH772_17780 ENOG4107Y80 Major Facilitator superfamily GH772_17790 ENOG4105FQP Beta-lactamase GH772_17835 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) GH772_17845 ENOG4105T9C HD domain GH772_17870 ENOG4105DBI uridine monophosphokinase GH772_17885 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GH772_17890 ENOG4107QX3 carboxylase GH772_17895 ENOG4105E39 Enoyl-CoA hydratase GH772_17900 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GH772_17905 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GH772_17910 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GH772_17915 ENOG4105C1G acyl-Coa dehydrogenase GH772_17930 ENOG4107Z3H Transcriptional regulator, TetR family GH772_17940 ENOG4105CJ1 ABC, transporter GH772_17950 ENOG4105DIN metallophosphoesterase GH772_17960 ENOG4107RF6 penicillin-binding protein GH772_17965 ENOG4107RF6 penicillin-binding protein GH772_17990 ENOG4105CIN aminoacyl-histidine dipeptidase GH772_18015 ENOG4107RA9 decarboxylase GH772_18025 ENOG41088CC tellurite resistance protein tehB GH772_18045 ENOG4108RZE Tetr family transcriptional regulator GH772_18065 ENOG4105C1J atp-dependent rna helicase GH772_18075 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) GH772_18095 ENOG4107STF Involved in phosphonate degradation (By similarity) GH772_18105 ENOG4105RD7 BadF BadG BcrA BcrD GH772_18130 ENOG4105F32 YngK protein GH772_18150 ENOG4108KPJ rna polymerase sigma factor GH772_18190 ENOG4108JCI Transcriptional regulator GH772_18210 ENOG4105BZ1 (ABC) transporter GH772_18215 ENOG4105BZ1 (ABC) transporter GH772_18230 ENOG4108RPX mosc domain containing protein GH772_18235 ENOG4105DND Transcriptional regulator GH772_18250 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GH772_18255 ENOG4107V2S Transcriptional regulator GH772_18275 ENOG410667J hydrolase GH772_18295 ENOG4105VEQ Cold shock protein GH772_18305 ENOG41068WN GH772_18315 ENOG4105C1Q protoporphyrinogen oxidase GH772_18340 ENOG4105WCN acetyltransferase GH772_18360 ENOG4105EYF MMPL domain protein GH772_18385 ENOG41081I9 integral membrane protein GH772_18410 ENOG4108D32 Methyltransferase GH772_18445 ENOG4105C19 ABC transporter GH772_18450 ENOG4105C22 threonyL-tRNA synthetase GH772_18455 ENOG4105FE9 pseudouridine synthase GH772_18485 ENOG4105BZG amino acid carrier protein GH772_18505 ENOG4105K70 DNA-binding protein GH772_18520 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_18530 ENOG4105CEY Amp-dependent synthetase and ligase GH772_18535 ENOG4105WQI isochorismatase GH772_18540 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GH772_18545 ENOG4105E4F Isochorismate synthase GH772_18550 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GH772_18555 ENOG4105FCD Major Facilitator GH772_18585 ENOG4107RFY SbcCD D subunit GH772_18600 ENOG4105E39 Enoyl-CoA hydratase GH772_18605 ENOG4105N14 lysine exporter protein LysE YggA GH772_18615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GH772_18620 ENOG4105C1G acyl-Coa dehydrogenase GH772_18625 ENOG4105CR4 methylisocitrate lyase GH772_18630 ENOG4105DXD 2-methylcitrate dehydratase GH772_18640 ENOG4105W8X HesB YadR YfhF-family protein GH772_18645 ENOG4105CZM Major Facilitator GH772_18655 ENOG4105BZ4 penicillin-binding protein GH772_18705 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GH772_18735 ENOG4108AEY RNA polymerase sigma factor GH772_18765 ENOG4108TFU terminase (Small subunit) GH772_18775 ENOG4105SZ6 Thioredoxin GH772_18785 ENOG410841Q phosphoesterase PA-phosphatase related protein GH772_18790 ENOG4108N23 SpoOM-related protein GH772_18830 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GH772_18835 ENOG4108JUB Transcriptional regulator GH772_18840 ENOG4108TSC N-acetyltransferase GH772_18845 ENOG4107S4Y M20 DapE family protein YgeY GH772_18860 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GH772_18885 ENOG4105C37 (CBS) domain GH772_18920 ENOG4105E90 ABC transporter GH772_18925 ENOG4108IJ8 ABC transporter GH772_18985 ENOG4106KNT transcriptional regulator GH772_18995 ENOG4105WH1 Two component transcriptional regulator luxr family GH772_19000 ENOG4105BZU Histidine kinase GH772_19005 ENOG4105D8X mechanosensitive ion channel GH772_19035 ENOG4105F0I Aminotransferase GH772_19040 ENOG4108MES Periplasmic binding protein GH772_19060 ENOG4105CAQ asparagine synthetase GH772_19065 ENOG4107Y70 Heat shock protein GH772_19070 ENOG4108KF3 Electron transport protein SCO1 SenC GH772_19075 ENOG4105E8R UPF0173 metal-dependent hydrolase GH772_19080 ENOG4108RCR degv family GH772_19090 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GH772_19100 ENOG4108UT2 hemolysin iii GH772_19105 ENOG4105E9Q Acyl-transferase GH772_19110 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GH772_19115 ENOG4107RVG penicillin-binding protein GH772_19135 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) GH772_19150 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 GH772_19175 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase GH772_19180 ENOG4105KD7 acetyltransferase GH772_19195 ENOG4105C0A alcohol dehydrogenase GH772_19200 ENOG4105CY2 Citrate transporter GH772_19205 ENOG4107XGZ Hydrolase GH772_19225 ENOG4105C8J )-transporter GH772_19230 ENOG4105C5S asparaginyl-tRNA synthetase GH772_19235 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GH772_19285 ENOG4107YX5 Pfam:DUF548 GH772_19315 ENOG4108UUM single-stranded DNA-binding protein GH772_19330 ENOG4105C5H ABC transporter GH772_19355 ENOG4105MCT stage V sporulation protein S GH772_19390 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) GH772_19395 ENOG4108IFG nitrite reductase, (NAD(P)H) GH772_19400 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GH772_19405 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GH772_19410 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GH772_19415 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GH772_19445 ENOG4108ZAF Molybdopterin GH772_19450 ENOG4105CVM Molybdenum cofactor synthesis domain protein GH772_19455 ENOG4105D06 uba thif-type nad fad binding protein GH772_19460 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GH772_19465 ENOG4107V6Q Cyclic nucleotide-binding domain GH772_19475 ENOG4105R3A Nitrate reductase GH772_19480 ENOG4108IUE nitrate reductase beta subunit GH772_19490 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GH772_19505 ENOG4108V06 Glutathione peroxidase GH772_19515 ENOG4105CNW domain protein GH772_19530 ENOG4105EMN RNA polymerase sigma factor GH772_19535 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein GH772_19590 ENOG4105XSJ toxin secretion phage lysis holin GH772_19715 ENOG410682Q Phage transcriptional regulator, ArpU GH772_19755 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GH772_19775 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_19820 ENOG41067QW Transcriptional regulator GH772_19835 ENOG4105VTR Integrase GH772_19840 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GH772_19860 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GH772_19885 ENOG4105KBJ sporulation protein ytfj GH772_19910 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GH772_19940 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH772_19945 ENOG4108JYZ YitT family GH772_19950 ENOG41087PP glycosyltransferase MGT family GH772_19965 ENOG4107RBS Methyltransferase GH772_19970 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GH772_19980 ENOG4108X4Q Hydrolase GH772_20005 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GH772_20015 ENOG4108VXD carboxy-peptidase GH772_20025 ENOG4108ZRV stage ii sporulation protein p GH772_20045 ENOG4108Z7R Chaperone CsaA GH772_20065 ENOG4105C37 (CBS) domain GH772_20070 ENOG4105SXS Protein of unknown function (DUF456) GH772_20090 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GH772_20100 ENOG4108S4H thioesterase Superfamily protein GH772_20110 ENOG4108PJD permease GH772_20125 ENOG4107T5V SNARE associated Golgi GH772_20145 ENOG4105CVJ phosphoglycerate mutase GH772_20170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GH772_20180 ENOG4105K4T epimerase GH772_20185 ENOG4105DSE periplasmic solute binding protein GH772_20195 ENOG4105CKI cobalamin synthesis protein GH772_20200 ENOG4107QM2 Aldo Keto reductase GH772_20205 ENOG4105VMI -acetyltransferase GH772_20220 ENOG4105DEN Luciferase family GH772_20235 ENOG4108WPJ Ferritin-like domain GH772_20240 ENOG4108K88 Membrane GH772_20255 ENOG4105C8Q Methyl-accepting chemotaxis GH772_20280 ENOG4107XZQ multidrug resistance protein GH772_20285 ENOG4105CPC Aldo Keto reductase GH772_20290 ENOG4105YVS arsR family transcriptional regulator GH772_20295 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase GH772_20300 ENOG4105ESP cell wall surface anchor family protein GH772_20305 ENOG4105ESP cell wall surface anchor family protein GH772_20310 ENOG4105D2M Aldolase GH772_20315 ENOG4105DE4 1-phosphofructokinase GH772_20320 ENOG4105CE4 GlcNAc 6-P deacetylase GH772_20325 ENOG4105E70 isomerase GH772_20330 ENOG4105DKQ ROK family GH772_20335 ENOG4105CT8 Phosphorylase GH772_20340 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GH772_20345 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GH772_20355 ENOG4108KB1 transcriptional regulator, arac family GH772_20375 ENOG4105KRN Transcriptional regulator, abrb family GH772_20425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH772_20430 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GH772_20440 ENOG4105YWU small acid-soluble spore protein GH772_20445 ENOG4105VRR gCN5-related N-acetyltransferase GH772_20450 ENOG4105KT7 mgtC SapB transporter GH772_20460 ENOG4107VMI polysaccharide deacetylase GH772_20465 ENOG4105BZU Histidine kinase GH772_20470 ENOG4108KGH TRANSCRIPTIONal GH772_20495 ENOG4105D6E homoserine dehydrogenase GH772_20515 ENOG4108ZJ4 polysaccharide deacetylase GH772_20520 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GH772_20540 ENOG4105BZU Histidine kinase GH772_20545 ENOG4105EFI regulatoR GH772_20550 ENOG4105BZ1 (ABC) transporter GH772_20580 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GH772_20605 ENOG4108UT6 Transferase hexapeptide repeat containing protein GH772_20615 ENOG4105K64 Glycosyl transferase, family 2 GH772_20625 ENOG4108JJ8 (ABC) transporter GH772_20630 ENOG4108JJ9 ABC, transporter GH772_20635 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GH772_20640 ENOG4105C4M (Ubiquinol oxidase) subunit I GH772_20660 ENOG4105MDS 4-oxalocrotonate tautomerase GH772_20670 ENOG4105SKE transcriptional Regulator LysR family GH772_20680 ENOG4105C32 Amino acid ABC transporter (Permease) GH772_20685 ENOG4108IV0 ABC, transporter GH772_20690 ENOG4105C0Z ABC transporter GH772_20700 ENOG4105CKI cobalamin synthesis protein GH772_20710 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GH772_20715 ENOG4106F5Q Membrane GH772_20720 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GH772_20725 ENOG4108TVJ Nitroreductase GH772_20730 ENOG4107ZXU DSBA oxidoreductase GH772_20735 ENOG4108Z40 Transcriptional regulator GH772_20740 ENOG4105GZI Transcriptional regulator GH772_20745 ENOG4107RT3 EamA-like transporter family GH772_20750 ENOG4105KTB nuclear export factor GLE1 GH772_20755 ENOG4108T5E Copper resistance protein GH772_20800 ENOG4107RAQ aminopeptidase GH772_20820 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GH772_20825 ENOG4105D9N nucleoside GH772_20835 ENOG4107RHR regulatoR GH772_20865 ENOG4105C0X amino acid GH772_20870 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GH772_20885 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GH772_20900 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH772_20905 ENOG41068WN GH772_20915 ENOG4105F6J Alpha beta hydrolase fold GH772_20935 ENOG4105CYC Transferase GH772_20940 ENOG4105DY9 regulatoR GH772_20950 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b GH772_20955 ENOG4105C6X Major Facilitator GH772_20980 ENOG4105C7B Threonine dehydratase GH772_20990 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GH772_20995 ENOG4108ZP8 Acetolactate synthase small subunit GH772_21000 ENOG4105C7K acetolactate synthase GH772_21005 ENOG4105CM2 brancheD-chain amino acid aminotransferase GH772_21010 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GH772_21025 ENOG4105H67 Protein of unknown function (DUF421) GH772_21030 ENOG4105X5K response regulator receiver protein GH772_21040 ENOG4105C8J )-transporter GH772_21060 ENOG4105C6T cysteine synthase GH772_21065 ENOG4105EU0 Major facilitator Superfamily GH772_21075 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GH772_21090 ENOG4105DXI Major Facilitator superfamily GH772_21100 ENOG4105U3E Transcriptional regulator GH772_21105 ENOG4105CSR polyphosphate kinase 2 GH772_21150 ENOG4105FVX GH772_21210 ENOG4105C6K Malic enzyme GH772_21215 ENOG4108IJ0 Aspartate ammonia-lyase GH772_21225 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) GH772_21245 ENOG4105CJ1 ABC, transporter GH772_21280 ENOG4106BRA Membrane GH772_21320 ENOG4105EC3 peptidase S51, dipeptidase E GH772_21325 ENOG4107QJQ Mate efflux family protein GH772_21345 ENOG4105C9Q fumarate hydratase class II GH772_21350 ENOG4105DFD Na H antiporter GH772_21360 ENOG4108UZ3 Transporter GH772_21365 ENOG4105DRR Transcriptional regulator, GntR family GH772_21375 ENOG4105PGM cation diffusion facilitator family transporter GH772_21395 ENOG4105CAQ asparagine synthetase GH772_21400 ENOG4105EKQ RNA-directed DNA polymerase GH772_21405 ENOG4105CAQ asparagine synthetase GH772_21415 ENOG4105K56 Transcriptional regulator GH772_21435 ENOG4105CVJ phosphoglycerate mutase GH772_21460 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr GH772_21475 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GH772_21480 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component GH772_21490 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH772_21495 ENOG4105DUM transcriptional regulator, lysR family GH772_21520 ENOG4108U4N (sortase) family GH772_21540 ENOG4105KAC Antibiotic biosynthesis monooxygenase GH772_21575 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GH772_21580 ENOG4105KTQ flagellar basal-body rod protein GH772_21585 ENOG4105FZW flagellar biosynthesis regulator FlhF GH772_21590 ENOG4105D7B Flagellar biosynthesis protein flha GH772_21595 ENOG4105D00 flagellar biosynthetic protein flhB GH772_21605 ENOG4105VS8 Flagellar biosynthetic protein fliq GH772_21610 ENOG4105CN7 Flagellar biosynthetic protein FliP GH772_21620 ENOG4105DD5 Flagellar motor switch protein GH772_21625 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GH772_21635 ENOG4105E4C Lytic transglycosylase catalytic GH772_21640 ENOG4105I03 Flagellin GH772_21645 ENOG4105I03 Flagellin GH772_21655 ENOG4107R88 Chemotaxis protein (CheV) GH772_21670 ENOG4105BZE flagellar hook protein, FlgE GH772_21700 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GH772_21705 ENOG4107U2N Flagellar M-ring protein GH772_21710 ENOG41075Z6 flagellar hook-basal body complex protein fliE GH772_21715 ENOG4108ZC9 flagellar basal-body rod protein flgc GH772_21720 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GH772_21735 ENOG4107TPX flagellar hook-associated GH772_21740 ENOG4105DTJ flagellar hook-associated protein GH772_21745 ENOG4105E1Q flagellar hook-associated protein GH772_21765 ENOG4105BZU Histidine kinase GH772_21780 ENOG4105DD5 Flagellar motor switch protein GH772_21785 ENOG4105CBS Chea signal transduction histidine kinase GH772_21790 ENOG4107YTP response regulator receiver protein GH772_21795 ENOG4105ER2 Ompa motb domain protein GH772_21800 ENOG4107R0U MotA TolQ exbB proton channel GH772_21810 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GH772_21840 ENOG4107Y80 Major Facilitator superfamily GH772_21875 ENOG41080C8 DUF218 domain GH772_21880 ENOG4105H67 Protein of unknown function (DUF421) GH772_21895 ENOG4108Z5V transcriptional regulator, merr family GH772_21900 ENOG4105CN5 Metallo-Beta-Lactamase GH772_21905 ENOG4107RWR Sodium hydrogen exchanger GH772_21915 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GH772_21980 ENOG41081VK Ribonuclease GH772_22035 ENOG4106032 Glutathionylspermidine synthase GH772_22060 ENOG4105KHC sulfurtransferase GH772_22070 ENOG4108W0I acetyltransferase GH772_22080 ENOG410890F Dynamin family GH772_22085 ENOG4105DHF Membrane GH772_22090 ENOG4105C2W permease GH772_22105 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GH772_22115 ENOG4105CTD carboxy-peptidase GH772_22120 ENOG4105DVT helicase GH772_22130 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GH772_22185 ENOG4105BZ4 penicillin-binding protein GH772_22195 ENOG4105CSM endonuclease III GH772_22215 ENOG4105YAC GH772_22220 ENOG4105DVT helicase GH772_22255 ENOG4105CPK Glycosyl transferase (Group 1 GH772_22260 ENOG4105FJR Lmbe family GH772_22275 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GH772_22280 ENOG4108JYZ YitT family GH772_22320 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GH772_22325 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) GH772_22340 ENOG41068YB TPR repeat-containing protein GH772_22345 ENOG4105CIH Imidazole acetol-phosphate transaminase GH772_22365 ENOG4105EAH synthase GH772_22375 ENOG4105XXQ heptaprenyl diphosphate synthase component I GH772_22390 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GH772_22420 ENOG41065D1 GH772_22425 ENOG4105S2F GH772_22455 ENOG4105HDK L-asparaginase GH772_22460 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GH772_22485 ENOG4108S6Z Negative regulator of genetic competence GH772_22490 ENOG4107X2D transcriptional regulator, merr family GH772_22495 ENOG4107RGJ metallophosphoesterase GH772_22505 ENOG4105I7S Abortive infection protein GH772_22510 ENOG4105C9U ATP-dependent DNA helicase RecQ GH772_22525 ENOG4108SAX Membrane GH772_22535 ENOG41063SB peptidase GH772_22540 ENOG4108WBT adenosyltransferase GH772_22545 ENOG4105BZU Histidine kinase GH772_22550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_22555 ENOG4105CRE cytochrome C GH772_22560 ENOG4107TWT Cytochrome c biogenesis protein GH772_22570 ENOG4105FE9 pseudouridine synthase GH772_22580 ENOG4108JIC nucleoside recognition domain protein GH772_22585 ENOG4105DZ1 carboxypeptidase GH772_22590 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GH772_22620 ENOG4105BZU Histidine kinase GH772_22635 ENOG4105I3N Conserved Protein GH772_22640 ENOG4105BZU Histidine kinase GH772_22655 ENOG4105BZ4 penicillin-binding protein GH772_22660 ENOG4107GRR phosphate transport regulator GH772_22665 ENOG4105CJ3 phosphate transporter GH772_22710 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) GH772_22730 ENOG4105WH1 Two component transcriptional regulator luxr family GH772_22735 ENOG4105ENE Histidine kinase GH772_22755 ENOG4105DFD Na H antiporter GH772_22775 ENOG4105C8J )-transporter GH772_22780 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GH772_22785 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GH772_22790 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GH772_22800 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GH772_22805 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GH772_22825 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GH772_22835 ENOG4105E0M Sulfatase GH772_22840 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GH772_22855 ENOG4107RVV histidinol phosphate phosphatase, hisj family GH772_22930 ENOG4108ZP8 Acetolactate synthase small subunit GH772_22935 ENOG4105C7K acetolactate synthase GH772_22940 ENOG4105CM2 brancheD-chain amino acid aminotransferase GH772_22960 ENOG4105KBJ sporulation protein ytfj GH772_22965 ENOG41063Y9 GH772_22970 ENOG4105CZN Potassium uptake protein GH772_23005 ENOG4107QMU Mate efflux family protein GH772_23030 ENOG4105NQC Flavodoxin GH772_23050 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GH772_23060 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GH772_23065 ENOG4105EA8 2-Nitropropane dioxygenase GH772_23070 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GH772_23110 ENOG4105CJ1 ABC, transporter GH772_23120 ENOG4105CZV ABC transporter GH772_23125 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GH772_23130 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GH772_23150 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GH772_23190 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GH772_23195 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase GH772_23205 ENOG4105BZU Histidine kinase GH772_23210 ENOG4106DF1 GH772_23220 ENOG41090MY MarR family Transcriptional regulator GH772_23225 ENOG4105BZU Histidine kinase GH772_23235 ENOG4105PXI polysaccharide deacetylase GH772_23245 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GH772_23255 ENOG4105E98 transcriptional regulator DeoR family GH772_23275 ENOG4107RCV ABC transporter, permease GH772_23280 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH772_23285 ENOG4105C4Y ABC transporter GH772_23310 ENOG4105CHR reductase GH772_23330 ENOG4108Z7G MaoC domain protein dehydratase GH772_23335 ENOG410681C small acid-soluble spore protein GH772_23340 ENOG4105CZN Potassium uptake protein GH772_23345 ENOG4107TS3 membrane protein, TerC GH772_23350 ENOG4108QTI )-transporter GH772_23360 ENOG4106A3R peptidase GH772_23380 ENOG4105JXH GntR family transcriptional regulator GH772_23385 ENOG4105BZU Histidine kinase GH772_23390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_23405 ENOG4105CQB FAD linked oxidase domain protein GH772_23410 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GH772_23415 ENOG4105K4I Scp-like extracellular GH772_23425 ENOG4108YBP pseudouridine synthase GH772_23435 ENOG4105EYF MMPL domain protein GH772_23445 ENOG4107RUE extracellular solute-binding protein family 1 GH772_23450 ENOG4105D38 putrescine abc transporter GH772_23455 ENOG4105F38 ABC transporter, permease GH772_23465 ENOG4105C26 Dehydrogenase GH772_23500 ENOG4105VFR signal peptidase GH772_23505 ENOG4105DZ1 carboxypeptidase GH772_23530 ENOG4105DZR Type I site-specific deoxyribonuclease GH772_23540 ENOG4105CVR type I restriction-modification system GH772_23545 ENOG4105VTR Integrase GH772_23565 ENOG4105W5Q DNA repair protein (RadC GH772_23635 ENOG4105VZ8 Transcriptional regulator GH772_23645 ENOG4105C7S Dehydrogenase GH772_23760 ENOG4105DDQ anthranilate synthase GH772_23765 ENOG4105CRQ synthase (Component I) GH772_23770 ENOG4105CK7 Sodium proline symporter GH772_23845 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GH772_23855 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase GH772_23860 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GH772_23880 ENOG4107TVC Glycosyl transferase, family 2 GH772_23900 ENOG4105K64 Glycosyl transferase, family 2 GH772_23920 ENOG4105EMS pseudouridine synthase GH772_23935 ENOG4106EFP UPF0738 protein GH772_23940 ENOG4105MIX Adenylate cyclase GH772_23945 ENOG4108Z18 K06886 hemoglobin GH772_23955 ENOG4105DPN Oligoendopeptidase f GH772_23965 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GH772_23975 ENOG4108ZCF integral membrane protein GH772_23995 ENOG4105UQX Mate efflux family protein GH772_24000 ENOG4108JQ7 (ABC) transporter GH772_24010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GH772_24015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH772_24030 ENOG4105C31 Tryptophanyl-tRNA synthetase GH772_24045 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GH772_24050 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GH772_24085 ENOG4108KP7 hydrolase GH772_24095 ENOG41073B9 GH772_24100 ENOG4107AYK membrAne GH772_24110 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GH772_24115 ENOG4105QNR S1 RNA binding domain protein GH772_24135 ENOG4105BZU Histidine kinase GH772_24140 ENOG4105CH6 catalase GH772_24150 ENOG4105CAQ asparagine synthetase GH772_24175 ENOG4105ERH Fumarylacetoacetate hydrolase GH772_24245 ENOG4105XVF Competence transcription factor GH772_24260 ENOG4105VEQ Cold shock protein GH772_24275 ENOG4107QP3 malate synthase g GH772_24280 ENOG4105ZU5 s-layer protein GH772_24300 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GH772_24325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GH772_24340 ENOG41086D8 Transcriptional regulator GH772_24345 ENOG4108AEY RNA polymerase sigma factor GH772_24355 ENOG4107TVP HD domain protein GH772_24365 ENOG4107RN3 metallophosphoesterase GH772_24370 ENOG4105ENX hydrolase GH772_24430 ENOG4105CNA YD repeat protein GH772_24445 ENOG4105CEY Amp-dependent synthetase and ligase GH772_24455 ENOG4105DF9 Lipoate-protein, ligase GH772_24460 ENOG4108RQ5 Beta-lactamase domain-containing protein GH772_24465 ENOG4106AXD GH772_24475 ENOG4105D29 Helix-turn-helix type 11 domain protein GH772_24505 ENOG4105ECB domain protein GH772_24535 ENOG4105C1Q protoporphyrinogen oxidase GH772_24540 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GH772_24550 ENOG4105BZ4 penicillin-binding protein GH772_24555 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GH772_24560 ENOG4105CKV Membrane GH772_24565 ENOG410905X membrane-flanked domain protein GH772_24595 ENOG4105CKV Membrane GH772_24600 ENOG410905X membrane-flanked domain protein GH772_24630 ENOG4105K59 histidine triad (HIT) protein GH772_24655 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GH772_24660 ENOG4105EEM helicase GH772_24670 ENOG4105CNI cell division protein FtsW GH772_24680 ENOG4105EMN RNA polymerase sigma factor GH772_24690 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GH772_24705 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GH772_24735 ENOG4108MUZ hydrolase GH772_24755 ENOG4105EQ0 Major Facilitator superfamily GH772_24760 ENOG4108IND Tetr family transcriptional regulator GH772_24770 ENOG4106D4I domain protein GH772_24775 ENOG4107VRP DNA repair exonuclease GH772_24815 ENOG4105K8R UPF0145 protein GH772_24835 ENOG4105BZU Histidine kinase GH772_24840 ENOG4105BZU Histidine kinase GH772_24845 ENOG4108MJI response regulator GH772_24855 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GH772_24865 ENOG4105WN5 stage II sporulation protein GH772_24960 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GH772_24980 ENOG4105CMT Dihydroxyacetone kinase GH772_24990 ENOG4105CMT Dihydroxyacetone kinase GH772_25005 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GH772_25075 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_25095 ENOG4105CDU Replicative dna helicase GH772_25190 ENOG4108MRH transcriptional regulatory protein GH772_25200 ENOG4105CSH Transporter GH772_25255 ENOG4105DER m42 family GH772_25285 ENOG4105CGU Enoyl-CoA hydratase GH772_25300 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GH772_25305 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GH772_25315 ENOG4106AKK s-layer domain-containing protein GH772_25350 ENOG4105CHH sulfate transporter GH772_25365 ENOG4105EKQ RNA-directed DNA polymerase GH772_25380 ENOG4105D4P Coproporphyrinogen iii oxidase GH772_25385 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GH772_25400 ENOG4107FQX Alpha-acetolactate decarboxylase GH772_25435 ENOG410839P GH772_25450 ENOG4105CDA abc transporter atp-binding protein GH772_25455 ENOG4105DRP amino acid AbC transporter GH772_25465 ENOG4105BZ1 (ABC) transporter GH772_25470 ENOG4105BZ1 (ABC) transporter GH772_25475 ENOG4105C26 Dehydrogenase GH772_25480 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GH772_25485 ENOG4105D5Q Arginine ornithine antiporter GH772_25495 ENOG4107RKG DJ-1/PfpI family GH772_25505 ENOG4105E5W Transporter GH772_25510 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) GH772_25515 ENOG4105NF4 modulator of drug activity GH772_25535 ENOG4105EKQ RNA-directed DNA polymerase GH772_25545 ENOG4105K8R UPF0145 protein GH772_25555 ENOG4105EWC Purine nucleoside phosphorylase GH772_25580 ENOG4106A3M Cytochrome p-450 GH772_25600 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_25605 ENOG41061H0 Monooxygenase GH772_25610 ENOG41082F9 transcriptional regulator GH772_25630 ENOG4105KPY Small multidrug resistance protein GH772_25635 ENOG4105KPY Small multidrug resistance protein GH772_25645 ENOG4108YXU transcriptional regulator AsnC family GH772_25685 ENOG4106KNT transcriptional regulator GH772_25695 ENOG4107RWR Sodium hydrogen exchanger GH772_25700 ENOG4105CUB amino acid GH772_25735 ENOG4107T5V SNARE associated Golgi GH772_25770 ENOG4105WEF catalase GH772_25800 ENOG4105C19 ABC transporter GH772_25805 ENOG4107RBB ABC transporter, permease GH772_25810 ENOG41069ER domain protein GH772_25835 ENOG4105VZJ PTS System GH772_25840 ENOG4105VCP PTS System GH772_25845 ENOG4105EMD TRANSCRIPTIONal GH772_25870 ENOG4108KGH TRANSCRIPTIONal GH772_25880 ENOG41087NI Sulfite exporter TauE/SafE GH772_25885 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GH772_25895 ENOG4105VFE sira family GH772_25900 ENOG4105VFE sira family GH772_25905 ENOG4105VFE sira family GH772_25910 ENOG4107TPS domain protein GH772_25915 ENOG4105VFE sira family GH772_25920 ENOG4105XTG Pfam:DUF156 GH772_25925 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase GH772_25950 ENOG4105ED1 spovr family GH772_25955 ENOG4107Y03 Nitroreductase GH772_25975 ENOG4108B31 Spore germination protein GH772_26010 ENOG4105C5Y PTS System GH772_26030 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein GH772_26040 ENOG4105C7N Xanthine uracil vitamin C permease GH772_26045 ENOG4108QGH periplasmic GH772_26050 ENOG4105C2J ABC transporter GH772_26055 ENOG4105F5R ABC transporter GH772_26065 ENOG4105C19 ABC transporter GH772_26090 ENOG4108INS Transcriptional regulator GH772_26140 ENOG4105DWF phosphomethylpyrimidine kinase GH772_26145 ENOG4105D06 uba thif-type nad fad binding protein GH772_26160 ENOG41080HI glycine oxidase GH772_26165 ENOG4108VEU Thiamine monophosphate synthase GH772_26175 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GH772_26185 ENOG4105ETU transcriptional activator (TenA GH772_26205 ENOG41080XQ Signal transduction protein with cbs domains GH772_26330 ENOG4105E2Z phosphate ABC transporter (Permease GH772_26335 ENOG4105C8U phosphate abc transporter GH772_26340 ENOG4105CVA phosphate GH772_26345 ENOG4105CE1 Ferrous iron transport protein b GH772_26350 ENOG4105CE1 Ferrous iron transport protein b GH772_26355 ENOG4105CE1 Ferrous iron transport protein b GH772_26375 ENOG4105E1V na solute symporter GH772_26380 ENOG4106CAD Protein of unknown function (DUF3311) GH772_26400 ENOG4105E2S oxidase) subunit II GH772_26405 ENOG4105BZ9 Cytochrome C oxidase, subunit I GH772_26430 ENOG4105MA6 gCN5-related N-acetyltransferase GH772_26445 ENOG4105C7N Xanthine uracil vitamin C permease GH772_26450 ENOG4105C85 amino acid GH772_26470 ENOG4105DUX Transporter GH772_26485 ENOG4107D63 GH772_26490 ENOG4105VZ8 Transcriptional regulator GH772_26495 ENOG41069ER domain protein GH772_26500 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GH772_26560 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) GH772_26565 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GH772_26570 ENOG4105CNN ABC, transporter GH772_26575 ENOG4105C2J ABC transporter GH772_26585 ENOG4108RVA ribokinase GH772_26590 ENOG4105ETE Transcriptional regulator (LacI family GH772_26595 ENOG4105C0R drug resistance transporter emrb qaca subfamily GH772_26600 ENOG41067TZ transcriptional regulator, MarR family GH772_26605 ENOG4105CXY transporter GH772_26615 ENOG4108JQ7 (ABC) transporter GH772_26620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GH772_26630 ENOG4105DEF Extracellular solute-binding protein, family 5 GH772_26640 ENOG41068KF Universal stress protein GH772_26645 ENOG4105CHH sulfate transporter GH772_26660 ENOG4105BZU Histidine kinase GH772_26665 ENOG4105NAE bifunctional deaminase-reductase domain protein GH772_26670 ENOG4105D29 Helix-turn-helix type 11 domain protein GH772_26680 ENOG4105GFR rna polymerase sigma factor GH772_26695 ENOG4108IQI permease GH772_26700 ENOG4105DRP amino acid AbC transporter GH772_26705 ENOG4105EAD ABC transporter GH772_26710 ENOG4105CT1 (ABC) transporter GH772_26715 ENOG4105CDA abc transporter atp-binding protein GH772_26720 ENOG4105BZG amino acid carrier protein GH772_26725 ENOG4105CRN Aminoglycoside phosphotransferase GH772_26730 ENOG4105E1K spore germination protein GH772_26745 ENOG4105CG3 alpha amylase, catalytic region GH772_26750 ENOG4105C5Y PTS System GH772_26755 ENOG4107414 GntR family transcriptional regulator GH772_26760 ENOG4105D5Q Arginine ornithine antiporter GH772_26765 ENOG4105BZU Histidine kinase GH772_26780 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GH772_26785 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GH772_26790 ENOG4107T89 von Willebrand factor, type A GH772_26800 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GH772_26805 ENOG4105EXW epimerase dehydratase GH772_26815 ENOG4105DMQ Methyltransferase GH772_26820 ENOG4105E0A ABC, transporter GH772_26825 ENOG4108IHU transport system permease protein GH772_26830 ENOG4105DQ5 transport system permease protein GH772_26835 ENOG4108MES Periplasmic binding protein GH772_26840 ENOG4105DUX Transporter GH772_26855 ENOG4105DAA L-lactate GH772_26865 ENOG4108IJ0 Aspartate ammonia-lyase GH772_26870 ENOG4105C37 (CBS) domain GH772_26875 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GH772_26880 ENOG4105D9N nucleoside GH772_26885 ENOG4108KGH TRANSCRIPTIONal GH772_26890 ENOG41073R8 VanW family GH772_26925 ENOG4105DAP Nicotinate phosphoribosyltransferase GH772_26930 ENOG4105C59 p-type ATPase GH772_26940 ENOG4105CUB amino acid GH772_26960 ENOG4108JB9 formate dehydrogenase GH772_26965 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GH772_26970 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) GH772_26975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GH772_26980 ENOG4105BZU Histidine kinase GH772_26990 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GH772_26995 ENOG4108UZ3 Transporter GH772_27015 ENOG4105US7 Histidine kinase GH772_27020 ENOG4108STX response regulator GH772_27025 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) GH772_27030 ENOG4105BZ7 extracellular solute-binding protein family 1 GH772_27035 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component GH772_27040 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GH772_27045 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) GH772_27050 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GH772_27075 ENOG4105D4T Citrate transporter GH772_27080 ENOG4108V9W transcriptional regulatory protein GH772_27085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GH772_27095 ENOG4105DZ6 Band 7 protein GH772_27110 ENOG4105C94 Transporter GH772_27130 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GH772_27330 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GH772_27355 ENOG4105CDU Replicative dna helicase GH772_27390 ENOG41067QW Transcriptional regulator GH772_27420 ENOG4105CYN Serine protein kinase GH772_27425 ENOG4105BZU Histidine kinase GH772_27430 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GH772_27440 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GH772_27455 ENOG4108R9S DSBA oxidoreductase GH772_27460 ENOG4108JQC penicillin-binding protein 1A GH772_27570 ENOG4105G5W regulator Fur family GH772_27575 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH772_27595 ENOG4108IUW ABC transporter GH772_27605 ENOG4105CBC glutamate synthase GH772_27610 ENOG4107NBY Membrane GH772_27615 ENOG4105BZ1 (ABC) transporter GH772_27635 ENOG4106BXE GH772_27640 ENOG4105CEN a g-specific adenine glycosylase GH772_27645 ENOG41067AE Membrane-bound metal-dependent hydrolase GH772_27675 ENOG4105ECP epimerase GH772_27680 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) GH772_27700 ENOG4105F1A Pyruvate formate-lyase GH772_27720 ENOG4105C3I Nad-dependent epimerase dehydratase GH772_27725 ENOG4107QQG Dehydrogenase GH772_27730 ENOG4105CKK Glycosyl transferase, family 2 GH772_27745 ENOG4108A04 Beta-lactamase GH772_27755 ENOG4105CSV Glutaminase GH772_27785 ENOG4108IQI permease GH772_27795 ENOG4108JUB Transcriptional regulator GH772_27845 ENOG4105UPD Calcium Proton GH772_27850 ENOG410606W general stress protein GH772_27865 ENOG4107ZTW SNARE associated Golgi GH772_27875 ENOG4105C3F Signal peptidase i GH772_27890 ENOG4108IPJ Membrane GH772_27895 ENOG4105C59 p-type ATPase GH772_27900 ENOG4107U9T Pfam:Ribonuclease_BN GH772_27910 ENOG4105KJF protein tyrosine phosphatase GH772_27930 ENOG4108TTB tellurium resistance protein GH772_27935 ENOG4107TS3 membrane protein, TerC GH772_27940 ENOG4106FN3 tellurium resistance protein GH772_27945 ENOG4106FN3 tellurium resistance protein GH772_27950 ENOG4108N0M stress protein GH772_27980 ENOG4105DEU major facilitator superfamily GH772_28000 ENOG41062JF Transcriptional regulator GH772_28030 ENOG4105C5H ABC transporter GH772_28050 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component GH772_28065 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter GH772_28095 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) GH772_28120 ENOG4105C19 ABC transporter GH772_28125 ENOG4107RBB ABC transporter, permease GH772_28150 ENOG4105CI1 PTS System GH772_28160 ENOG4105C8Q Methyl-accepting chemotaxis GH772_28170 ENOG4105EAB amino acid AbC transporter GH772_28175 ENOG4105E5Q amino acid AbC transporter GH772_28180 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase GH772_28205 ENOG4105D2S major facilitator superfamily GH772_28210 ENOG410756H nucleotidyltransferase GH772_28240 ENOG4106UIA GH772_28245 ENOG4106UIA GH772_28265 ENOG4108V5C ABC transporter GH772_28270 ENOG4105DQ5 transport system permease protein GH772_28275 ENOG4105EHG Permease protein GH772_28290 ENOG4107W7X Aldolase GH772_28300 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GH772_28305 ENOG4105D3R alkyl hydroperoxide reductase GH772_28325 ENOG4105DFD Na H antiporter GH772_28335 ENOG4105DTQ mandelate racemase muconate lactonizing GH772_28350 ENOG4108W15 Protein of unknown function (DUF1456) GH772_28360 ENOG4107Y80 Major Facilitator superfamily GH772_28370 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GH772_28375 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GH772_28395 ENOG4105CWC Acetylornithine deacetylase GH772_28405 ENOG4105CQB FAD linked oxidase domain protein GH772_28410 ENOG4105DDC Oxidoreductase domain protein GH772_28435 ENOG4108W15 Protein of unknown function (DUF1456) GH772_28445 ENOG4105C7K acetolactate synthase GH772_28450 ENOG4105BZU Histidine kinase GH772_28460 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GH772_28465 ENOG4105D9N nucleoside GH772_28480 ENOG4105KPY Small multidrug resistance protein GH772_28485 ENOG4105C26 Dehydrogenase GH772_28495 ENOG4108JPW Aminotransferase GH772_28500 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) GH772_28505 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase GH772_28510 ENOG4105CBD Diacylglycerol kinase GH772_28530 ENOG4107I77 yiaA/B two helix domain GH772_28535 ENOG410834F Transcriptional regulator GH772_28555 ENOG4105D01 (LipO)protein GH772_28560 ENOG4108UMI ABC transporter, permease GH772_28570 ENOG4108W2Y isochorismatase GH772_28595 ENOG4105C4R Atp-dependent dna helicase GH772_28620 ENOG4105C12 Phosphoribosylglycinamide synthetase GH772_28630 ENOG4108V3E phosphoribosylglycinamide formyltransferase GH772_28655 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GH772_28665 ENOG4105C83 adenylosuccinate lyase GH772_28670 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GH772_28675 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)