locus-tag	class	description
I0K14_00010	COG0592	DNA-directed DNA polymerase activity
I0K14_00015	COG2501	S4 domain
I0K14_00025	COG0187	DNA topoisomerase II activity
I0K14_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0K14_00065	COG0516	GMP reductase activity
I0K14_00065	COG0517	IMP dehydrogenase activity
I0K14_00070	COG1686	Belongs to the peptidase S11 family
I0K14_00100	COG1428	Deoxynucleoside kinase
I0K14_00105	COG1428	Deoxynucleoside kinase
I0K14_00110	COG1335	isochorismatase
I0K14_00115	COG0590	tRNA wobble adenosine to inosine editing
I0K14_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I0K14_00180	COG1982	Orn Lys Arg decarboxylase major
I0K14_00190	COG0470	DNA polymerase III
I0K14_00195	COG1774	PSP1 C-terminal conserved region
I0K14_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I0K14_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I0K14_00220	COG2002	toxin-antitoxin pair type II binding
I0K14_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_00230	COG0084	hydrolase, TatD family'
I0K14_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I0K14_00250	COG4466	Protein conserved in bacteria
I0K14_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I0K14_00270	COG0251	oxidation-reduction process
I0K14_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I0K14_00305	COG2002	toxin-antitoxin pair type II binding
I0K14_00310	COG2244	polysaccharide biosynthetic process
I0K14_00315	COG3956	TIGRFAM MazG family protein
I0K14_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I0K14_00340	COG1098	S1 RNA binding domain
I0K14_00355	COG2208	phosphoserine phosphatase activity
I0K14_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I0K14_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I0K14_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K14_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I0K14_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
I0K14_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I0K14_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I0K14_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I0K14_00420	COG1396	sequence-specific DNA binding
I0K14_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0K14_00515	COG3880	PFAM UvrB UvrC protein
I0K14_00525	COG0542	response to heat
I0K14_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I0K14_00540	COG4956	integral membrane protein (PIN domain superfamily)
I0K14_00560	COG1045	serine acetyltransferase
I0K14_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0K14_00580	COG3688	RNA-binding protein containing a PIN domain
I0K14_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0K14_00600	COG0250	Participates in transcription elongation, termination and antitermination
I0K14_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I0K14_00625	COG2813	Specifically methylates the guanine in position
I0K14_00640	COG1358	cellular component organization or biogenesis
I0K14_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
I0K14_00770	COG0201	protein transport
I0K14_00780	COG0024	Methionine aminopeptidase
I0K14_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I0K14_00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I0K14_00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I0K14_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_00855	COG0489	protein tyrosine kinase activity
I0K14_00865	COG2194	sulfuric ester hydrolase activity
I0K14_00870	COG0726	polysaccharide deacetylase
I0K14_00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
I0K14_00955	COG4856	YbbR-like protein
I0K14_00975	COG0596	Alpha beta hydrolase
I0K14_00995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I0K14_01020	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_01025	COG2011	ABC-type metal ion transport system permease component
I0K14_01035	COG1464	Belongs to the NlpA lipoprotein family
I0K14_01040	COG0604	alcohol dehydrogenase
I0K14_01050	COG0277	FAD linked oxidase domain protein
I0K14_01055	COG2271	Major facilitator Superfamily
I0K14_01065	COG2814	Major facilitator Superfamily
I0K14_01085	COG0601	transmembrane transport
I0K14_01090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_01095	COG0444	Belongs to the ABC transporter superfamily
I0K14_01100	COG4608	Belongs to the ABC transporter superfamily
I0K14_01105	COG4166	transmembrane transport
I0K14_01115	COG2207	Transcriptional regulator
I0K14_01130	COG4166	transmembrane transport
I0K14_01135	COG4166	transmembrane transport
I0K14_01140	COG0656	L-ascorbic acid biosynthetic process
I0K14_01145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_01155	COG4149	molybdate abc transporter
I0K14_01160	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0K14_01165	COG1910	domain protein
I0K14_01180	COG0697	spore germination
I0K14_01195	COG0204	Acyl-transferase
I0K14_01205	COG1609	Transcriptional regulator
I0K14_01215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_01225	COG0084	hydrolase, TatD family'
I0K14_01230	COG5298	Protein conserved in bacteria
I0K14_01255	COG0488	(ABC) transporter
I0K14_01270	COG0747	negative chemotaxis
I0K14_01275	COG0601	transmembrane transport
I0K14_01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_01285	COG0444	Belongs to the ABC transporter superfamily
I0K14_01290	COG4608	Belongs to the ABC transporter superfamily
I0K14_01295	COG0561	phosphatase activity
I0K14_01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
I0K14_01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0K14_01340	COG0531	amino acid
I0K14_01345	COG2814	Major facilitator Superfamily
I0K14_01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0K14_01365	COG4294	response to UV
I0K14_01370	COG0705	Rhomboid family
I0K14_01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I0K14_01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0K14_01390	COG0864	Transcriptional regulator
I0K14_01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
I0K14_01400	COG2183	response to ionizing radiation
I0K14_01495	COG0802	atpase or kinase
I0K14_01500	COG1214	PFAM Peptidase M22, glycoprotease
I0K14_01505	COG0456	acetyltransferase
I0K14_01515	COG0488	(ABC) transporter
I0K14_01530	COG1266	CAAX protease self-immunity
I0K14_01550	COG2252	PERMEase
I0K14_01560	COG5002	protein histidine kinase activity
I0K14_01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0K14_01615	COG2226	methyltransferase
I0K14_01635	COG1215	transferase activity, transferring glycosyl groups
I0K14_01670	COG2205	protein histidine kinase activity
I0K14_01675	COG0745	RESPONSE REGULATOR receiver
I0K14_01700	COG0697	spore germination
I0K14_01725	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I0K14_01730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I0K14_01735	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I0K14_01745	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I0K14_01760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I0K14_01770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I0K14_01780	COG0151	Belongs to the GarS family
I0K14_01805	COG0210	DNA helicase
I0K14_01815	COG4851	CamS sex pheromone cAM373 precursor
I0K14_01835	COG1335	isochorismatase
I0K14_01840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I0K14_01845	COG2011	ABC-type metal ion transport system permease component
I0K14_01850	COG1464	Belongs to the NlpA lipoprotein family
I0K14_01865	COG0003	Pfam Anion-transporting ATPase
I0K14_01870	COG1846	Transcriptional regulator
I0K14_01875	COG4682	membrane
I0K14_01895	COG1597	lipid kinase activity
I0K14_01900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0K14_01905	COG0546	phosphoglycolate phosphatase activity
I0K14_01910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I0K14_01920	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_01925	COG2076	Multidrug Resistance protein
I0K14_01930	COG2309	aminopeptidase activity
I0K14_01945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_01955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I0K14_01960	COG5002	protein histidine kinase activity
I0K14_01965	COG4807	Protein conserved in bacteria
I0K14_01990	COG1757	Na H antiporter
I0K14_01995	COG1473	amidohydrolase
I0K14_02010	COG0450	alkyl hydroperoxide reductase
I0K14_02040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_02050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_02065	COG0166	Belongs to the GPI family
I0K14_02105	COG3541	Predicted nucleotidyltransferase
I0K14_02110	COG2814	Major facilitator Superfamily
I0K14_02115	COG0723	plastoquinol--plastocyanin reductase activity
I0K14_02115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_02125	COG0765	amino acid transport
I0K14_02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_02140	COG0840	transmembrane signaling receptor activity
I0K14_02165	COG0549	Belongs to the carbamate kinase family
I0K14_02170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K14_02180	COG0277	FAD linked oxidase domain protein
I0K14_02185	COG0366	Alpha amylase catalytic
I0K14_02190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_02190	COG2190	(PTS) system
I0K14_02190	COG1263	PTS System
I0K14_02225	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I0K14_02240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_02250	COG1116	anion transmembrane transporter activity
I0K14_02260	COG0488	(ABC) transporter
I0K14_02310	COG2270	Major facilitator Superfamily
I0K14_02340	COG2310	stress, protein
I0K14_02345	COG2310	stress, protein
I0K14_02350	COG2310	stress, protein
I0K14_02355	COG0861	Integral membrane protein TerC family
I0K14_02365	COG3853	Toxic anion resistance protein (TelA)
I0K14_02380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I0K14_02390	COG1295	ribonuclease BN
I0K14_02395	COG2217	Heavy metal translocating P-type atpase
I0K14_02400	COG0697	spore germination
I0K14_02420	COG0586	Pfam SNARE associated Golgi protein
I0K14_02435	COG3871	stress protein (general stress protein 26)
I0K14_02440	COG0387	Pfam Sodium calcium exchanger
I0K14_02450	COG0535	radical SAM domain protein
I0K14_02470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0K14_02490	COG3829	transcription factor binding
I0K14_02500	COG0833	amino acid
I0K14_02505	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K14_02535	COG1263	PTS System
I0K14_02535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_02540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_02555	COG0463	Glycosyl transferase, family 2
I0K14_02565	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I0K14_02565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K14_02570	COG0463	Glycosyl transferase, family 2
I0K14_02585	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I0K14_02605	COG0402	S-adenosylhomocysteine deaminase activity
I0K14_02610	COG1090	epimerase
I0K14_02640	COG1988	membrane-bound metal-dependent
I0K14_02645	COG1194	a g-specific adenine glycosylase
I0K14_02670	COG1132	(ABC) transporter
I0K14_02675	COG4129	membrane
I0K14_02680	COG0069	glutamate synthase activity
I0K14_02680	COG0067	glutamate synthase
I0K14_02680	COG0070	glutamate synthase
I0K14_02690	COG4555	ABC transporter
I0K14_02710	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I0K14_02715	COG0735	belongs to the Fur family
I0K14_02825	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I0K14_02830	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I0K14_02840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I0K14_02850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I0K14_02860	COG2766	serine protein kinase
I0K14_02880	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K14_02890	COG1585	Membrane protein implicated in regulation of membrane protease activity
I0K14_02895	COG2268	Band 7 protein
I0K14_02905	COG3290	protein histidine kinase activity
I0K14_02910	COG4565	transcriptional regulatory protein
I0K14_02915	COG2851	Citrate transporter
I0K14_02940	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I0K14_02945	COG3842	ATPase activity
I0K14_02950	COG1175	transmembrane transport
I0K14_02955	COG0395	ABC-type sugar transport system, permease component
I0K14_02965	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I0K14_02970	COG0745	RESPONSE REGULATOR receiver
I0K14_02975	COG5002	protein histidine kinase activity
I0K14_02985	COG4990	cell redox homeostasis
I0K14_02995	COG0697	spore germination
I0K14_03000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_03010	COG5002	protein histidine kinase activity
I0K14_03015	COG0745	RESPONSE REGULATOR receiver
I0K14_03020	COG0454	-acetyltransferase
I0K14_03020	COG0456	acetyltransferase
I0K14_03025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0K14_03030	COG3383	formate dehydrogenase (NAD+) activity
I0K14_03035	COG2427	Protein of unknown function (DUF1641)
I0K14_03050	COG0531	amino acid
I0K14_03055	COG0640	Transcriptional regulator
I0K14_03060	COG2217	Heavy metal translocating P-type atpase
I0K14_03065	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I0K14_03080	COG3227	Zinc metalloprotease (Elastase)
I0K14_03100	COG2720	vancomycin resistance protein
I0K14_03105	COG1316	TRANSCRIPTIONal
I0K14_03110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_03115	COG0346	lactoylglutathione lyase activity
I0K14_03120	COG1253	flavin adenine dinucleotide binding
I0K14_03125	COG1027	Aspartate ammonia-lyase
I0K14_03130	COG1620	l-lactate permease
I0K14_03145	COG3104	oligopeptide transport
I0K14_03150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_03155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_03160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_03170	COG2226	methyltransferase
I0K14_03175	COG0156	8-amino-7-oxononanoate synthase activity
I0K14_03180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I0K14_03185	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I0K14_03195	COG4548	von Willebrand factor, type A
I0K14_03200	COG0714	Associated with various cellular activities
I0K14_03205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_03225	COG0531	amino acid
I0K14_03230	COG2188	Transcriptional regulator
I0K14_03235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_03235	COG1263	PTS System
I0K14_03240	COG0366	Alpha amylase catalytic
I0K14_03255	COG0697	spore germination
I0K14_03260	COG4585	Histidine kinase
I0K14_03265	COG2197	response regulator
I0K14_03270	COG1404	Belongs to the peptidase S8 family
I0K14_03285	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K14_03290	COG1115	amino acid carrier protein
I0K14_03295	COG1126	abc transporter atp-binding protein
I0K14_03300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_03305	COG0765	amino acid transport
I0K14_03310	COG0765	amino acid transport
I0K14_03315	COG0833	amino acid
I0K14_03330	COG1595	DNA-templated transcription, initiation
I0K14_03340	COG2378	regulation of single-species biofilm formation
I0K14_03345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0K14_03350	COG5002	protein histidine kinase activity
I0K14_03365	COG0659	secondary active sulfate transmembrane transporter activity
I0K14_03380	COG0747	negative chemotaxis
I0K14_03390	COG0601	transmembrane transport
I0K14_03395	COG4608	Belongs to the ABC transporter superfamily
I0K14_03405	COG2271	Major facilitator Superfamily
I0K14_03410	COG1846	Transcriptional regulator
I0K14_03415	COG0477	Major facilitator Superfamily
I0K14_03420	COG1609	Transcriptional regulator
I0K14_03425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I0K14_03440	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_03445	COG1879	ABC-type sugar transport system periplasmic component
I0K14_03470	COG1063	alcohol dehydrogenase
I0K14_03490	COG3568	Endonuclease Exonuclease Phosphatase
I0K14_03520	COG0840	transmembrane signaling receptor activity
I0K14_03525	COG3584	3D domain protein
I0K14_03525	COG3583	domain protein
I0K14_03530	COG1476	TRANSCRIPTIONal
I0K14_03550	COG3104	oligopeptide transport
I0K14_03555	COG1114	Component of the transport system for branched-chain amino acids
I0K14_03570	COG1113	amino acid transport
I0K14_03575	COG2252	PERMEase
I0K14_03590	COG2153	protein acetylation
I0K14_03600	COG0569	domain protein
I0K14_03600	COG0475	glutathione-regulated potassium exporter activity
I0K14_03615	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I0K14_03620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I0K14_03625	COG0833	amino acid
I0K14_03630	COG4990	cell redox homeostasis
I0K14_03645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_03650	COG0697	spore germination
I0K14_03655	COG0531	amino acid
I0K14_03670	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K14_03675	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K14_03680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I0K14_03680	COG1918	ferrous iron import across plasma membrane
I0K14_03685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0K14_03690	COG0573	inorganic phosphate transmembrane transporter activity
I0K14_03695	COG0581	inorganic phosphate transmembrane transporter activity
I0K14_03705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0K14_03825	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
I0K14_03845	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0K14_03850	COG1116	anion transmembrane transporter activity
I0K14_03855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_03860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K14_03865	COG0352	thiamine-phosphate diphosphorylase activity
I0K14_03870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_03875	COG2104	thiamine diphosphate biosynthetic process
I0K14_03885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_03890	COG0351	phosphomethylpyrimidine kinase
I0K14_03930	COG2205	protein histidine kinase activity
I0K14_03935	COG2814	Major facilitator Superfamily
I0K14_03940	COG1846	Transcriptional regulator
I0K14_03955	COG2252	PERMEase
I0K14_03960	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_04020	COG0778	Nitroreductase
I0K14_04025	COG2719	SpoVR family
I0K14_04035	COG0446	pyridine nucleotide-disulphide oxidoreductase
I0K14_04040	COG1937	Protein conserved in bacteria
I0K14_04045	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_04045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_04050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_04050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_04055	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_04060	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_04065	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_04065	COG0425	Belongs to the sulfur carrier protein TusA family
I0K14_04075	COG2210	Belongs to the sulfur carrier protein TusA family
I0K14_04080	COG0730	response to heat
I0K14_04090	COG1316	TRANSCRIPTIONal
I0K14_04095	COG0604	alcohol dehydrogenase
I0K14_04100	COG1283	sodium-dependent phosphate transmembrane transporter activity
I0K14_04105	COG2814	Major facilitator Superfamily
I0K14_04115	COG3711	transcriptional antiterminator
I0K14_04115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_04120	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K14_04125	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K14_04150	COG3584	3D domain protein
I0K14_04150	COG1388	LysM domain
I0K14_04155	COG1396	sequence-specific DNA binding
I0K14_04165	COG4824	toxin secretion phage lysis holin
I0K14_04175	COG0791	NLP P60 protein
I0K14_04175	COG1388	LysM domain
I0K14_04180	COG3584	3D domain protein
I0K14_04180	COG3583	domain protein
I0K14_04185	COG0577	efflux transmembrane transporter activity
I0K14_04190	COG1136	(ABC) transporter
I0K14_04200	COG5522	Integral membrane protein (intg_mem_TP0381)
I0K14_04215	COG1114	Component of the transport system for branched-chain amino acids
I0K14_04220	COG3546	catalase activity
I0K14_04255	COG0586	Pfam SNARE associated Golgi protein
I0K14_04290	COG0531	amino acid
I0K14_04295	COG0475	glutathione-regulated potassium exporter activity
I0K14_04305	COG1737	Transcriptional regulator
I0K14_04315	COG1263	PTS System
I0K14_04315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_04325	COG2259	Doxx family
I0K14_04345	COG1522	sequence-specific DNA binding
I0K14_04360	COG2076	Multidrug Resistance protein
I0K14_04365	COG1309	transcriptional regulator
I0K14_04370	COG2814	Major facilitator Superfamily
I0K14_04380	COG1846	Transcriptional regulator
I0K14_04385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I0K14_04390	COG0477	Major facilitator Superfamily
I0K14_04395	COG0657	acetylesterase activity
I0K14_04400	COG0657	acetylesterase activity
I0K14_04410	COG2124	cytochrome p450
I0K14_04420	COG1063	alcohol dehydrogenase
I0K14_04425	COG1733	regulation of RNA biosynthetic process
I0K14_04435	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_04440	COG4533	DNA binding
I0K14_04445	COG2211	Major facilitator Superfamily
I0K14_04455	COG0693	protein deglycase activity
I0K14_04460	COG0753	catalase activity
I0K14_04470	COG0531	amino acid
I0K14_04475	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I0K14_04485	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_04490	COG1132	(ABC) transporter
I0K14_04495	COG1132	(ABC) transporter
I0K14_04500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_04505	COG0765	amino acid transport
I0K14_04510	COG1126	abc transporter atp-binding protein
I0K14_04525	COG0189	ligase activity
I0K14_04555	COG0028	Belongs to the TPP enzyme family
I0K14_04560	COG3527	Alpha-acetolactate decarboxylase
I0K14_04570	COG0561	phosphatase activity
I0K14_04580	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K14_04580	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_04585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0K14_04605	COG0659	secondary active sulfate transmembrane transporter activity
I0K14_04620	COG0653	protein targeting
I0K14_04625	COG2244	polysaccharide biosynthetic process
I0K14_04635	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_04640	COG4196	transglutaminase domain protein
I0K14_04655	COG1696	Membrane protein involved in D-alanine export
I0K14_04670	COG1024	Enoyl-CoA hydratase
I0K14_04690	COG1363	Peptidase, m42
I0K14_04730	COG0601	transmembrane transport
I0K14_04735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_04740	COG0444	Belongs to the ABC transporter superfamily
I0K14_04745	COG4608	Belongs to the ABC transporter superfamily
I0K14_04750	COG0477	Major facilitator Superfamily
I0K14_04755	COG3290	protein histidine kinase activity
I0K14_04760	COG4565	transcriptional regulatory protein
I0K14_04765	COG3181	Tripartite tricarboxylate transporter family receptor
I0K14_04800	COG1396	sequence-specific DNA binding
I0K14_04840	COG4974	Belongs to the 'phage' integrase family
I0K14_04855	COG0789	Transcriptional regulator
I0K14_04855	COG4978	Transcriptional regulator
I0K14_04870	COG0305	Participates in initiation and elongation during chromosome replication
I0K14_04895	COG0477	Major facilitator Superfamily
I0K14_04970	COG1183	phosphatidylcholine synthase activity
I0K14_04990	COG2376	Dihydroxyacetone kinase
I0K14_05000	COG2376	Dihydroxyacetone kinase
I0K14_05090	COG3237	CsbD-like
I0K14_05115	COG1191	sigma factor activity
I0K14_05125	COG2208	phosphoserine phosphatase activity
I0K14_05130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0K14_05135	COG2198	Histidine kinase
I0K14_05135	COG2205	protein histidine kinase activity
I0K14_05135	COG0784	Response regulator, receiver
I0K14_05180	COG2814	Major facilitator Superfamily
I0K14_05210	COG0420	3'-5' exonuclease activity
I0K14_05215	COG4717	serine-type aminopeptidase activity
I0K14_05235	COG0346	lactoylglutathione lyase activity
I0K14_05240	COG0346	lactoylglutathione lyase activity
I0K14_05245	COG0457	Tetratricopeptide repeat
I0K14_05255	COG2267	carboxylic ester hydrolase activity
I0K14_05270	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I0K14_05275	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I0K14_05285	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I0K14_05310	COG0772	Belongs to the SEDS family
I0K14_05325	COG0477	Major facilitator Superfamily
I0K14_05330	COG0477	Major facilitator Superfamily
I0K14_05340	COG3973	AAA domain
I0K14_05345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K14_05365	COG4980	gas vesicle protein
I0K14_05370	COG0537	adenosine 5'-monophosphoramidase activity
I0K14_05375	COG1131	(ABC) transporter
I0K14_05380	COG4473	ABC transporter
I0K14_05450	COG1309	transcriptional regulator
I0K14_05460	COG3402	PFAM membrane-flanked domain
I0K14_05465	COG3428	Bacterial PH domain
I0K14_05495	COG3402	PFAM membrane-flanked domain
I0K14_05500	COG3428	Bacterial PH domain
I0K14_05510	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_05515	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_05530	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I0K14_05555	COG1309	transcriptional regulator
I0K14_05560	COG1511	domain protein
I0K14_05580	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I0K14_05590	COG2378	regulation of single-species biofilm formation
I0K14_05595	COG1609	Transcriptional regulator
I0K14_05605	COG1234	tRNA 3'-trailer cleavage
I0K14_05610	COG0095	Lipoate-protein ligase
I0K14_05620	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_05665	COG1408	metallophosphoesterase
I0K14_05670	COG1078	dGTPase activity
I0K14_05680	COG1595	DNA-templated transcription, initiation
I0K14_05685	COG2207	Transcriptional regulator
I0K14_05685	COG3708	Transcriptional regulator
I0K14_05690	COG2205	protein histidine kinase activity
I0K14_05695	COG0745	RESPONSE REGULATOR receiver
I0K14_05720	COG0501	Belongs to the peptidase M48B family
I0K14_05725	COG0697	spore germination
I0K14_05745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I0K14_05750	COG2224	Isocitrate lyase
I0K14_05775	COG4903	ComK protein
I0K14_05780	COG4585	Histidine kinase
I0K14_05785	COG2197	response regulator
I0K14_05795	COG0398	Pfam SNARE associated Golgi protein
I0K14_05855	COG0179	Fumarylacetoacetate (FAA) hydrolase
I0K14_05880	COG0367	asparagine synthase
I0K14_05885	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I0K14_05890	COG0753	catalase activity
I0K14_05895	COG0004	ammonium transporteR
I0K14_05915	COG2996	Protein conserved in bacteria
I0K14_05920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K14_05930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_05945	COG0561	phosphatase activity
I0K14_05965	COG2267	carboxylic ester hydrolase activity
I0K14_05980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_05985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I0K14_05990	COG5504	Zn-dependent protease
I0K14_06000	COG0180	Tryptophanyl-tRNA synthetase
I0K14_06010	COG4166	transmembrane transport
I0K14_06015	COG0601	transmembrane transport
I0K14_06020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_06025	COG0444	Belongs to the ABC transporter superfamily
I0K14_06030	COG4608	Belongs to the ABC transporter superfamily
I0K14_06035	COG0534	Mate efflux family protein
I0K14_06040	COG4166	transmembrane transport
I0K14_06055	COG0861	Integral membrane protein TerC family
I0K14_06060	COG4862	establishment of competence for transformation
I0K14_06065	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_06075	COG1164	Oligoendopeptidase f
I0K14_06090	COG2346	COG2346, Truncated hemoglobins
I0K14_06095	COG4116	CYTH
I0K14_06105	COG2357	RelA SpoT domain protein
I0K14_06115	COG0564	pseudouridine synthase activity
I0K14_06130	COG0772	Belongs to the SEDS family
I0K14_06135	COG1216	Glycosyl transferase, family 2
I0K14_06135	COG0463	Glycosyl transferase, family 2
I0K14_06155	COG0457	Tetratricopeptide repeat
I0K14_06155	COG0463	Glycosyl transferase, family 2
I0K14_06175	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I0K14_06190	COG1091	dTDP-4-dehydrorhamnose reductase activity
I0K14_06235	COG2153	protein acetylation
I0K14_06245	COG2382	esterase
I0K14_06260	COG5492	domain, Protein
I0K14_06265	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_06275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I0K14_06275	COG0512	Glutamine amidotransferase of anthranilate synthase
I0K14_06320	COG1620	l-lactate permease
I0K14_06325	COG5634	Uncharacterized conserved protein (DUF2278)
I0K14_06385	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K14_06395	COG1476	TRANSCRIPTIONal
I0K14_06445	COG1686	Belongs to the peptidase S11 family
I0K14_06450	COG0681	Belongs to the peptidase S26 family
I0K14_06470	COG1396	sequence-specific DNA binding
I0K14_06485	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_06495	COG1176	ABC-type spermidine putrescine transport system, permease component I
I0K14_06500	COG1177	transmembrane transport
I0K14_06505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I0K14_06515	COG2409	Drug exporters of the RND superfamily
I0K14_06525	COG0564	pseudouridine synthase activity
I0K14_06535	COG2340	Cysteine-rich secretory protein family
I0K14_06540	COG0247	lactate metabolic process
I0K14_06545	COG0277	FAD linked oxidase domain protein
I0K14_06550	COG3835	regulator
I0K14_06560	COG0745	RESPONSE REGULATOR receiver
I0K14_06565	COG5002	protein histidine kinase activity
I0K14_06570	COG2186	Transcriptional regulator
I0K14_06590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I0K14_06600	COG2116	formate transmembrane transporter activity
I0K14_06605	COG0861	Integral membrane protein TerC family
I0K14_06610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K14_06620	COG2030	dehydratase
I0K14_06640	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_06645	COG3243	poly(R)-hydroxyalkanoic acid synthase
I0K14_06655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K14_06670	COG1840	ABC-type Fe3 transport system, periplasmic component
I0K14_06675	COG3842	ATPase activity
I0K14_06700	COG1349	DNA-binding transcription factor activity
I0K14_06710	COG0235	Class ii aldolase
I0K14_06720	COG2861	carbohydrate metabolic process
I0K14_06730	COG3852	Histidine kinase
I0K14_06735	COG1846	Transcriptional regulator
I0K14_06745	COG2318	DinB family
I0K14_06750	COG5002	protein histidine kinase activity
I0K14_06760	COG0720	synthase
I0K14_06775	COG4873	Protein conserved in bacteria
I0K14_06805	COG1780	Probably involved in ribonucleotide reductase function
I0K14_06820	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I0K14_06825	COG1725	Transcriptional regulator
I0K14_06830	COG1131	(ABC) transporter
I0K14_06840	COG1131	(ABC) transporter
I0K14_06845	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K14_06850	COG1266	CAAX protease self-immunity
I0K14_06860	COG1522	sequence-specific DNA binding
I0K14_06870	COG1335	isochorismatase
I0K14_06880	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K14_06885	COG2070	2-Nitropropane dioxygenase
I0K14_06890	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I0K14_06900	COG1696	Membrane protein involved in D-alanine export
I0K14_06925	COG0716	FMN binding
I0K14_06940	COG3173	Aminoglycoside phosphotransferase
I0K14_06980	COG1846	Transcriptional regulator
I0K14_06990	COG1301	dicarboxylic acid transport
I0K14_06995	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I0K14_07000	COG4709	membrane
I0K14_07005	COG3874	Sporulation protein YtfJ
I0K14_07025	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_07030	COG0028	Belongs to the TPP enzyme family
I0K14_07035	COG0440	acetolactate synthase activity
I0K14_07125	COG1183	phosphatidylcholine synthase activity
I0K14_07130	COG1368	sulfuric ester hydrolase activity
I0K14_07140	COG0019	diaminopimelate decarboxylase activity
I0K14_07160	COG0529	Catalyzes the synthesis of activated sulfate
I0K14_07165	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0K14_07185	COG1648	precorrin-2 dehydrogenase activity
I0K14_07190	COG0733	neurotransmitter:sodium symporter activity
I0K14_07215	COG1757	Na H antiporter
I0K14_07230	COG4758	membrane
I0K14_07235	COG4585	Histidine kinase
I0K14_07240	COG2197	response regulator
I0K14_07250	COG1114	Component of the transport system for branched-chain amino acids
I0K14_07260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0K14_07300	COG0730	response to heat
I0K14_07305	COG0306	phosphate transporter
I0K14_07310	COG1392	Phosphate transport regulator
I0K14_07315	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_07330	COG3852	Histidine kinase
I0K14_07335	COG1801	Protein of unknown function DUF72
I0K14_07345	COG0582	viral genome integration into host DNA
I0K14_07350	COG5002	protein histidine kinase activity
I0K14_07365	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I0K14_07365	COG0392	lysyltransferase activity
I0K14_07380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K14_07385	COG1686	Belongs to the peptidase S11 family
I0K14_07390	COG2715	membrane protein required for spore maturation
I0K14_07395	COG0700	Nucleoside recognition
I0K14_07400	COG1187	pseudouridine synthase activity
I0K14_07410	COG1333	cytochrome c biogenesis protein
I0K14_07415	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0K14_07420	COG0745	RESPONSE REGULATOR receiver
I0K14_07425	COG5002	protein histidine kinase activity
I0K14_07430	COG2096	Adenosyltransferase
I0K14_07435	COG4942	peptidase
I0K14_07445	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I0K14_07450	COG1141	Ferredoxin
I0K14_07460	COG0514	ATP-dependent DNA helicase (RecQ)
I0K14_07465	COG1266	CAAX protease self-immunity
I0K14_07475	COG1408	metallophosphoesterase
I0K14_07485	COG4862	establishment of competence for transformation
I0K14_07490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I0K14_07510	COG0492	ferredoxin-NADP+ reductase activity
I0K14_07585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K14_07600	COG0142	geranyltranstransferase activity
I0K14_07610	COG0142	geranyltranstransferase activity
I0K14_07630	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0K14_07635	COG0457	Tetratricopeptide repeat
I0K14_07655	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0K14_07660	COG2010	Cytochrome c
I0K14_07660	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I0K14_07665	COG4347	Protein of unknown function (DUF1405)
I0K14_07680	COG2738	Putative neutral zinc metallopeptidase
I0K14_07690	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_07695	COG1694	Mazg nucleotide pyrophosphohydrolase
I0K14_07710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K14_07715	COG0438	transferase activity, transferring glycosyl groups
I0K14_07750	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I0K14_07750	COG1199	ATP-dependent helicase activity
I0K14_07770	COG3935	DnaD domain protein
I0K14_07775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I0K14_07785	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K14_07785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_07845	COG0116	Belongs to the methyltransferase superfamily
I0K14_07855	COG1199	ATP-dependent helicase activity
I0K14_07860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I0K14_07880	COG2233	PERMEase
I0K14_07885	COG2311	Membrane
I0K14_07890	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K14_07900	COG0456	acetyltransferase
I0K14_07935	COG0754	glutathionylspermidine amidase activity
I0K14_07950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K14_07975	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0K14_07990	COG1215	transferase activity, transferring glycosyl groups
I0K14_07995	COG0438	transferase activity, transferring glycosyl groups
I0K14_08010	COG0454	-acetyltransferase
I0K14_08030	COG0328	RNA-DNA hybrid ribonuclease activity
I0K14_08065	COG3403	YqcI/YcgG family
I0K14_08070	COG1280	lysine exporter protein (LysE YggA)
I0K14_08085	COG3162	membrane
I0K14_08090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_08095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K14_08105	COG0475	glutathione-regulated potassium exporter activity
I0K14_08110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K14_08115	COG0789	Transcriptional regulator
I0K14_08115	COG4978	Transcriptional regulator
I0K14_08125	COG2323	membrane
I0K14_08130	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I0K14_08160	COG2814	Major facilitator Superfamily
I0K14_08170	COG2814	Major facilitator Superfamily
I0K14_08190	COG1923	regulation of RNA biosynthetic process
I0K14_08200	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0K14_08205	COG1360	Flagellar Motor Protein
I0K14_08210	COG2201	protein-glutamate methylesterase activity
I0K14_08215	COG0643	Histidine kinase
I0K14_08215	COG2198	Histidine kinase
I0K14_08220	COG1776	CheC inhibitor of MCP methylation
I0K14_08220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_08235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I0K14_08255	COG1256	bacterial-type flagellum assembly
I0K14_08260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K14_08280	COG1815	bacterial-type flagellum-dependent cell motility
I0K14_08285	COG1558	bacterial-type flagellum-dependent cell motility
I0K14_08295	COG1766	The M ring may be actively involved in energy transduction
I0K14_08300	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_08310	COG1157	protein secretion by the type III secretion system
I0K14_08345	COG0835	chemotaxis
I0K14_08345	COG0784	Response regulator, receiver
I0K14_08355	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K14_08360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I0K14_08365	COG0741	lytic transglycosylase activity
I0K14_08375	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_08380	COG1776	CheC inhibitor of MCP methylation
I0K14_08380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I0K14_08390	COG1338	Plays a role in the flagellum-specific transport system
I0K14_08395	COG1987	bacterial-type flagellum assembly
I0K14_08405	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0K14_08410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I0K14_08415	COG1419	protein localization to endoplasmic reticulum
I0K14_08420	COG4786	Flagellar basal body rod
I0K14_08455	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_08470	COG3764	Sortase (surface protein transpeptidase)
I0K14_08475	COG3764	Sortase (surface protein transpeptidase)
I0K14_08500	COG0583	DNA-binding transcription factor activity
I0K14_08505	COG3842	ATPase activity
I0K14_08510	COG0725	ABC transporter, periplasmic molybdate-binding protein
I0K14_08520	COG1234	tRNA 3'-trailer cleavage
I0K14_08540	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_08555	COG1686	Belongs to the peptidase S11 family
I0K14_08565	COG0406	alpha-ribazole phosphatase activity
I0K14_08585	COG1846	Transcriptional regulator
I0K14_08595	COG0367	asparagine synthase
I0K14_08625	COG1802	Transcriptional regulator
I0K14_08630	COG0697	spore germination
I0K14_08635	COG0438	transferase activity, transferring glycosyl groups
I0K14_08635	COG1216	Glycosyl transferase, family 2
I0K14_08640	COG1757	Na H antiporter
I0K14_08645	COG0114	fumarate hydratase activity
I0K14_08660	COG0534	Mate efflux family protein
I0K14_08665	COG3340	Belongs to the peptidase S51 family
I0K14_08705	COG2733	membrane
I0K14_08740	COG1131	(ABC) transporter
I0K14_08755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_08760	COG0528	UMP kinase activity
I0K14_08770	COG1027	Aspartate ammonia-lyase
I0K14_08775	COG0281	malic enzyme
I0K14_08780	COG4191	Histidine kinase
I0K14_08785	COG0784	Response regulator, receiver
I0K14_08790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K14_08850	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_08860	COG2814	Major facilitator Superfamily
I0K14_08875	COG3842	ATPase activity
I0K14_08880	COG2508	Transcriptional regulator
I0K14_08890	COG1175	transmembrane transport
I0K14_08895	COG0395	ABC-type sugar transport system, permease component
I0K14_08905	COG2188	Transcriptional regulator
I0K14_08910	COG2222	sugar isomerase
I0K14_08925	COG1105	Belongs to the carbohydrate kinase PfkB family
I0K14_08940	COG1695	Transcriptional regulator
I0K14_08950	COG0477	Major facilitator Superfamily
I0K14_08955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_08965	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0K14_08970	COG4166	transmembrane transport
I0K14_08975	COG2223	nitrite transmembrane transporter activity
I0K14_08980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K14_08995	COG2244	polysaccharide biosynthetic process
I0K14_09000	COG0733	neurotransmitter:sodium symporter activity
I0K14_09010	COG5566	PFAM Mor transcription activator
I0K14_09015	COG2323	membrane
I0K14_09030	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K14_09035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_09040	COG0028	Belongs to the TPP enzyme family
I0K14_09045	COG0440	acetolactate synthase activity
I0K14_09050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I0K14_09060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I0K14_09085	COG2814	Major facilitator Superfamily
I0K14_09090	COG3384	dioxygenase
I0K14_09100	COG3279	Response regulator of the LytR AlgR family
I0K14_09105	COG0427	acetyl-CoA hydrolase
I0K14_09125	COG1073	alpha beta
I0K14_09130	COG4166	transmembrane transport
I0K14_09165	COG0535	radical SAM domain protein
I0K14_09170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_09175	COG0745	RESPONSE REGULATOR receiver
I0K14_09195	COG1914	H( )-stimulated, divalent metal cation uptake system
I0K14_09210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0K14_09215	COG0531	amino acid
I0K14_09240	COG2390	Transcriptional regulator
I0K14_09250	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_09255	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I0K14_09265	COG4846	Membrane protein involved in cytochrome C biogenesis
I0K14_09275	COG0006	proline dipeptidase activity
I0K14_09290	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0K14_09315	COG1114	Component of the transport system for branched-chain amino acids
I0K14_09325	COG2372	response to copper ion
I0K14_09325	COG1276	copper resistance
I0K14_09330	COG4549	nuclear export factor GLE1
I0K14_09340	COG0697	spore germination
I0K14_09345	COG0583	DNA-binding transcription factor activity
I0K14_09350	COG1959	2 iron, 2 sulfur cluster binding
I0K14_09355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I0K14_09360	COG0778	Nitroreductase
I0K14_09370	COG0628	permease
I0K14_09380	COG1231	oxidoreductase activity
I0K14_09385	COG0523	cobalamin synthesis protein
I0K14_09395	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_09400	COG2030	dehydratase
I0K14_09405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_09415	COG0411	ABC transporter
I0K14_09445	COG1942	4-Oxalocrotonate Tautomerase
I0K14_09465	COG1271	oxidase subunit
I0K14_09470	COG1294	oxidase, subunit
I0K14_09475	COG4988	ABC transporter
I0K14_09480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I0K14_09490	COG1216	Glycosyl transferase, family 2
I0K14_09530	COG1686	Belongs to the peptidase S11 family
I0K14_09545	COG1388	LysM domain
I0K14_09545	COG0791	NLP P60 protein
I0K14_09555	COG1132	(ABC) transporter
I0K14_09560	COG0745	RESPONSE REGULATOR receiver
I0K14_09565	COG5002	protein histidine kinase activity
I0K14_09575	COG0300	oxidoreductase activity
I0K14_09595	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I0K14_09605	COG0460	homoserine dehydrogenase
I0K14_09630	COG1316	TRANSCRIPTIONal
I0K14_09650	COG1285	pathogenesis
I0K14_09655	COG1247	-acetyltransferase
I0K14_09665	COG2814	Major facilitator Superfamily
I0K14_09670	COG1279	arginine transmembrane transporter activity
I0K14_09680	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0K14_09715	COG0577	efflux transmembrane transporter activity
I0K14_09720	COG2002	toxin-antitoxin pair type II binding
I0K14_09725	COG1404	Belongs to the peptidase S8 family
I0K14_09730	COG0640	Transcriptional regulator
I0K14_09735	COG0667	Aldo Keto reductase
I0K14_09740	COG2814	Major facilitator Superfamily
I0K14_09765	COG0840	transmembrane signaling receptor activity
I0K14_09780	COG3949	Membrane
I0K14_09785	COG0783	Belongs to the Dps family
I0K14_09800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K14_09810	COG1231	oxidoreductase activity
I0K14_09815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_09820	COG4989	oxidoreductase activity
I0K14_09825	COG0523	cobalamin synthesis protein
I0K14_09830	COG0456	acetyltransferase
I0K14_09850	COG0803	Belongs to the bacterial solute-binding protein 9 family
I0K14_09850	COG3443	Belongs to the bacterial solute-binding protein 9 family
I0K14_09860	COG0702	epimerase
I0K14_09870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0K14_09880	COG4166	transmembrane transport
I0K14_09895	COG0406	alpha-ribazole phosphatase activity
I0K14_09905	COG5337	Spore coat protein CotH
I0K14_09910	COG1051	belongs to the nudix hydrolase family
I0K14_09915	COG0586	Pfam SNARE associated Golgi protein
I0K14_09920	COG2244	polysaccharide biosynthetic process
I0K14_09930	COG0701	Predicted permease
I0K14_09935	COG3689	TIGRFAM TIGR03943 family protein
I0K14_09940	COG1607	acyl-coa hydrolase
I0K14_09950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_09965	COG0702	epimerase
I0K14_09970	COG2839	Protein conserved in bacteria
I0K14_09975	COG1253	flavin adenine dinucleotide binding
I0K14_09990	COG1114	Component of the transport system for branched-chain amino acids
I0K14_09995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_10015	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_10025	COG1876	peptidase activity
I0K14_10035	COG0154	amidase activity
I0K14_10040	COG2211	Major facilitator Superfamily
I0K14_10065	COG0561	phosphatase activity
I0K14_10075	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I0K14_10080	COG4106	trans-aconitate 2-methyltransferase activity
I0K14_10095	COG1819	glycosyl
I0K14_10100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_10105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_10135	COG0456	acetyltransferase
I0K14_10160	COG3874	Sporulation protein YtfJ
I0K14_10185	COG2226	methyltransferase
I0K14_10205	COG1082	Xylose isomerase domain protein TIM barrel
I0K14_10210	COG0346	lactoylglutathione lyase activity
I0K14_10220	COG0604	alcohol dehydrogenase
I0K14_10225	COG1595	DNA-templated transcription, initiation
I0K14_10240	COG0426	domain, Protein
I0K14_10240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0K14_10250	COG0386	Belongs to the glutathione peroxidase family
I0K14_10255	COG1305	Transglutaminase-like
I0K14_10260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
I0K14_10265	COG0714	Associated with various cellular activities
I0K14_10280	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I0K14_10285	COG1140	nitrate reductase beta subunit
I0K14_10290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I0K14_10295	COG2181	nitrate reductase activity
I0K14_10300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K14_10305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0K14_10310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_10315	COG0303	'Molybdopterin
I0K14_10330	COG2223	nitrite transmembrane transporter activity
I0K14_10345	COG1648	precorrin-2 dehydrogenase activity
I0K14_10355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I0K14_10355	COG1587	Uroporphyrinogen-III synthase
I0K14_10360	COG2146	nitrite reductase [NAD(P)H] activity
I0K14_10365	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I0K14_10370	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
I0K14_10395	COG2359	stage V sporulation protein S
I0K14_10415	COG1418	mRNA catabolic process
I0K14_10420	COG0488	(ABC) transporter
I0K14_10435	COG0629	single-stranded DNA binding
I0K14_10450	COG1413	lyase activity
I0K14_10465	COG2136	Putative SAM-dependent methyltransferase
I0K14_10465	COG2521	methyltransferase
I0K14_10485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I0K14_10500	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I0K14_10505	COG0017	Asparaginyl-tRNA synthetase
I0K14_10525	COG1674	ftsk spoiiie
I0K14_10550	COG5444	nuclease activity
I0K14_10595	COG0733	neurotransmitter:sodium symporter activity
I0K14_10620	COG2610	gluconate transmembrane transporter activity
I0K14_10625	COG1454	alcohol dehydrogenase
I0K14_10630	COG1794	racemase activity, acting on amino acids and derivatives
I0K14_10640	COG0456	acetyltransferase
I0K14_10645	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I0K14_10655	COG1131	(ABC) transporter
I0K14_10660	COG4473	ABC transporter
I0K14_10670	COG0546	phosphoglycolate phosphatase activity
I0K14_10685	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_10690	COG3250	beta-galactosidase activity
I0K14_10705	COG0768	penicillin binding
I0K14_10715	COG0204	Acyl-transferase
I0K14_10720	COG1272	protein, Hemolysin III
I0K14_10730	COG0805	protein transport
I0K14_10740	COG1307	EDD domain protein, DegV family
I0K14_10745	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I0K14_10750	COG1999	signal sequence binding
I0K14_10755	COG0071	Belongs to the small heat shock protein (HSP20) family
I0K14_10760	COG0367	asparagine synthase
I0K14_10780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_10785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I0K14_10800	COG1335	isochorismatase
I0K14_10805	COG1051	belongs to the nudix hydrolase family
I0K14_10810	COG0071	Belongs to the small heat shock protein (HSP20) family
I0K14_10815	COG0668	transmembrane transport
I0K14_10820	COG4585	Histidine kinase
I0K14_10820	COG2203	Gaf domain
I0K14_10825	COG2197	response regulator
I0K14_10840	COG1064	alcohol dehydrogenase
I0K14_10865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I0K14_10900	COG0517	IMP dehydrogenase activity
I0K14_10900	COG1125	glycine betaine transport
I0K14_10905	COG1174	glycine betaine transport
I0K14_10940	COG1253	flavin adenine dinucleotide binding
I0K14_10945	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_10950	COG5506	Protein of unknown function (DUF1694)
I0K14_10965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K14_10970	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I0K14_10975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I0K14_10980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K14_10985	COG0456	acetyltransferase
I0K14_10990	COG3829	transcription factor binding
I0K14_10995	COG1509	lysine 2,3-aminomutase activity
I0K14_11030	COG4991	sh3 domain protein
I0K14_11030	COG3064	Membrane
I0K14_11030	COG0515	serine threonine protein kinase
I0K14_11035	COG4326	sporulation control protein
I0K14_11040	COG0671	phosphoesterase, PA-phosphatase related
I0K14_11045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K14_11050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_11060	COG3728	DNA packaging
I0K14_11060	COG5484	DNA packaging
I0K14_11090	COG1595	DNA-templated transcription, initiation
I0K14_11125	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I0K14_11165	COG4499	WXG100 protein secretion system (Wss), protein YukC
I0K14_11165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_11175	COG2814	Major facilitator Superfamily
I0K14_11180	COG4841	protein insertion into membrane
I0K14_11185	COG0372	Belongs to the citrate synthase family
I0K14_11190	COG2079	MmgE PrpD family protein
I0K14_11195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I0K14_11200	COG1960	acyl-CoA dehydrogenase activity
I0K14_11205	COG2084	Dehydrogenase
I0K14_11215	COG1280	lysine exporter protein (LysE YggA)
I0K14_11220	COG1024	Enoyl-CoA hydratase
I0K14_11235	COG0420	3'-5' exonuclease activity
I0K14_11265	COG2223	nitrite transmembrane transporter activity
I0K14_11270	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_11275	COG1169	isochorismate synthase
I0K14_11280	COG1021	2,3-dihydroxybenzoate-AMP ligase
I0K14_11285	COG1535	isochorismatase
I0K14_11285	COG3433	isochorismatase activity
I0K14_11290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I0K14_11295	COG3251	PFAM MbtH domain protein
I0K14_11300	COG2814	Major facilitator Superfamily
I0K14_11315	COG0776	regulation of translation
I0K14_11325	COG2318	DinB family
I0K14_11335	COG1115	amino acid carrier protein
I0K14_11365	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_11370	COG1187	pseudouridine synthase activity
I0K14_11375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0K14_11380	COG1136	(ABC) transporter
I0K14_11390	COG0596	Alpha beta hydrolase
I0K14_11395	COG2814	Major facilitator Superfamily
I0K14_11410	COG0028	Belongs to the TPP enzyme family
I0K14_11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_11480	COG1247	-acetyltransferase
I0K14_11505	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I0K14_11510	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I0K14_11520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_11530	COG1278	Cold shock
I0K14_11545	COG0010	Belongs to the arginase family
I0K14_11550	COG0561	phosphatase activity
I0K14_11560	COG1846	Transcriptional regulator
I0K14_11565	COG2814	Major facilitator Superfamily
I0K14_11570	COG0583	DNA-binding transcription factor activity
I0K14_11575	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0K14_11590	COG0583	DNA-binding transcription factor activity
I0K14_11595	COG2258	MOSC domain
I0K14_11610	COG1132	(ABC) transporter
I0K14_11615	COG1132	(ABC) transporter
I0K14_11630	COG1396	sequence-specific DNA binding
I0K14_11660	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0K14_11670	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
I0K14_11675	COG1595	DNA-templated transcription, initiation
I0K14_11700	COG1649	PFAM Uncharacterised BCR, COG1649
I0K14_11725	COG2971	BadF BadG BcrA BcrD
I0K14_11735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I0K14_11755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_11790	COG1309	transcriptional regulator
I0K14_11805	COG1136	(ABC) transporter
I0K14_11805	COG0577	efflux transmembrane transporter activity
I0K14_11810	COG3615	Tellurite resistance protein tehB
I0K14_11810	COG0500	methyltransferase
I0K14_11825	COG3961	Belongs to the TPP enzyme family
I0K14_11870	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0K14_11880	COG0110	maltose O-acetyltransferase activity
I0K14_11890	COG0768	penicillin binding
I0K14_11895	COG1595	DNA-templated transcription, initiation
I0K14_11905	COG0768	penicillin binding
I0K14_11910	COG0768	penicillin binding
I0K14_11915	COG2367	Beta-lactamase
I0K14_11920	COG1408	metallophosphoesterase
I0K14_11930	COG1131	(ABC) transporter
I0K14_11940	COG1309	transcriptional regulator
I0K14_11955	COG1960	acyl-CoA dehydrogenase activity
I0K14_11960	COG0439	Biotin carboxylase
I0K14_11965	COG0511	ligase activity, forming carbon-carbon bonds
I0K14_11970	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I0K14_11975	COG1024	Enoyl-CoA hydratase
I0K14_11980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I0K14_11985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K14_12005	COG0572	uridine kinase
I0K14_12010	COG1686	Belongs to the peptidase S11 family
I0K14_12035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I0K14_12040	COG2910	NAD(P)H-binding
I0K14_12060	COG3227	Zinc metalloprotease (Elastase)
I0K14_12105	COG2226	methyltransferase
I0K14_12130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_12135	COG2368	4-hydroxyphenylacetate
I0K14_12155	COG2323	membrane
I0K14_12160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I0K14_12180	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I0K14_12185	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
I0K14_12190	COG3773	Cell wall hydrolase
I0K14_12200	COG0745	RESPONSE REGULATOR receiver
I0K14_12205	COG2205	protein histidine kinase activity
I0K14_12215	COG0488	(ABC) transporter
I0K14_12225	COG1136	(ABC) transporter
I0K14_12230	COG0577	efflux transmembrane transporter activity
I0K14_12250	COG0460	homoserine dehydrogenase
I0K14_12255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_12265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I0K14_12300	COG5444	nuclease activity
I0K14_12350	COG2124	cytochrome p450
I0K14_12380	COG0561	phosphatase activity
I0K14_12415	COG5002	protein histidine kinase activity
I0K14_12420	COG0768	penicillin binding
I0K14_12425	COG1819	glycosyl
I0K14_12430	COG1794	racemase activity, acting on amino acids and derivatives
I0K14_12455	COG2205	protein histidine kinase activity
I0K14_12465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_12470	COG0604	alcohol dehydrogenase
I0K14_12475	COG0671	phosphoesterase, PA-phosphatase related
I0K14_12480	COG0768	penicillin binding
I0K14_12490	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_12545	COG0693	protein deglycase activity
I0K14_12550	COG0456	acetyltransferase
I0K14_12560	COG2814	Major facilitator Superfamily
I0K14_12575	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_12595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_12600	COG0697	spore germination
I0K14_12615	COG0494	nUDIX hydrolase
I0K14_12625	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_12635	COG2223	nitrite transmembrane transporter activity
I0K14_12650	COG2816	NAD+ diphosphatase activity
I0K14_12655	COG0592	DNA-directed DNA polymerase activity
I0K14_12660	COG1051	belongs to the nudix hydrolase family
I0K14_12690	COG3878	Protein conserved in bacteria
I0K14_12710	COG4667	esterase of the alpha-beta hydrolase superfamily
I0K14_12750	COG0322	excinuclease ABC activity
I0K14_12790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_12815	COG1011	Hydrolase
I0K14_12835	COG1523	belongs to the glycosyl hydrolase 13 family
I0K14_12840	COG3227	Zinc metalloprotease (Elastase)
I0K14_12850	COG0346	lactoylglutathione lyase activity
I0K14_12855	COG0201	protein transport
I0K14_12895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_12910	COG2959	enzyme of heme biosynthesis
I0K14_12945	COG1309	transcriptional regulator
I0K14_12975	COG3284	Transcriptional regulator
I0K14_12990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_12995	COG1349	DNA-binding transcription factor activity
I0K14_13010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0K14_13015	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K14_13020	COG0022	dehydrogenase e1 component
I0K14_13025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K14_13035	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_13040	COG0456	acetyltransferase
I0K14_13040	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_13050	COG0494	nUDIX hydrolase
I0K14_13075	COG4176	ABC-type proline glycine betaine transport system permease component
I0K14_13080	COG4175	Glycine betaine
I0K14_13080	COG0517	IMP dehydrogenase activity
I0K14_13110	COG2153	protein acetylation
I0K14_13115	COG3397	chitin binding
I0K14_13120	COG1819	glycosyl
I0K14_13140	COG2205	protein histidine kinase activity
I0K14_13145	COG2226	methyltransferase
I0K14_13150	COG2315	Protein conserved in bacteria
I0K14_13160	COG0658	competence protein
I0K14_13160	COG2333	competence protein COMEC
I0K14_13205	COG3973	AAA domain
I0K14_13220	COG2105	PFAM AIG2 family protein
I0K14_13225	COG0514	ATP-dependent DNA helicase (RecQ)
I0K14_13255	COG4637	Psort location Cytoplasmic, score
I0K14_13275	COG3397	chitin binding
I0K14_13290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I0K14_13295	COG1115	amino acid carrier protein
I0K14_13300	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_13305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I0K14_13315	COG3938	Belongs to the proline racemase family
I0K14_13320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I0K14_13370	COG1078	dGTPase activity
I0K14_13375	COG0586	Pfam SNARE associated Golgi protein
I0K14_13390	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I0K14_13395	COG0519	Catalyzes the synthesis of GMP from XMP
I0K14_13400	COG4166	transmembrane transport
I0K14_13410	COG4948	Mandelate Racemase Muconate Lactonizing
I0K14_13460	COG2936	dipeptidyl-peptidase activity
I0K14_13465	COG5002	protein histidine kinase activity
I0K14_13470	COG0745	RESPONSE REGULATOR receiver
I0K14_13510	COG1164	Oligoendopeptidase f
I0K14_13515	COG0531	amino acid
I0K14_13520	COG1522	sequence-specific DNA binding
I0K14_13535	COG1307	EDD domain protein, DegV family
I0K14_13575	COG2814	Major facilitator Superfamily
I0K14_13585	COG1664	Polymer-forming cytoskeletal
I0K14_13590	COG0789	Transcriptional regulator
I0K14_13595	COG4533	DNA binding
I0K14_13600	COG2814	Major facilitator Superfamily
I0K14_13600	COG0477	Major facilitator Superfamily
I0K14_13620	COG2261	transglycosylase associated protein
I0K14_13635	COG2226	methyltransferase
I0K14_13675	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I0K14_13685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I0K14_13700	COG1131	(ABC) transporter
I0K14_13750	COG0628	permease
I0K14_13760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K14_13765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_13770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K14_13815	COG2746	aminoglycoside 3-N-acetyltransferase activity
I0K14_13835	COG0697	spore germination
I0K14_13840	COG2318	DinB family
I0K14_13860	COG4912	Dna alkylation repair
I0K14_13870	COG0346	lactoylglutathione lyase activity
I0K14_13900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_13905	COG0861	Integral membrane protein TerC family
I0K14_13910	COG1368	sulfuric ester hydrolase activity
I0K14_13915	COG0488	(ABC) transporter
I0K14_13930	COG1033	growth of symbiont in host cell
I0K14_13930	COG2409	Drug exporters of the RND superfamily
I0K14_13935	COG1309	transcriptional regulator
I0K14_13950	COG0287	Prephenate dehydrogenase
I0K14_13955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I0K14_13965	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I0K14_13965	COG1605	Chorismate mutase
I0K14_14000	COG1388	LysM domain
I0K14_14000	COG3584	3D domain protein
I0K14_14010	COG1309	transcriptional regulator
I0K14_14030	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_14035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_14045	COG2390	Transcriptional regulator
I0K14_14050	COG1070	Carbohydrate kinase
I0K14_14075	COG2329	Antibiotic biosynthesis monooxygenase
I0K14_14090	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_14105	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_14110	COG4187	Peptidase family M20/M25/M40
I0K14_14115	COG1414	Transcriptional regulator
I0K14_14120	COG0833	amino acid
I0K14_14125	COG1690	Belongs to the RtcB family
I0K14_14130	COG3239	Fatty acid desaturase
I0K14_14140	COG1785	Belongs to the alkaline phosphatase family
I0K14_14150	COG3655	Transcriptional regulator
I0K14_14165	COG4377	Putative membrane peptidase family (DUF2324)
I0K14_14175	COG3279	Response regulator of the LytR AlgR family
I0K14_14190	COG0346	lactoylglutathione lyase activity
I0K14_14210	COG0714	Associated with various cellular activities
I0K14_14230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0K14_14235	COG0753	catalase activity
I0K14_14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_14245	COG1116	anion transmembrane transporter activity
I0K14_14260	COG1846	Transcriptional regulator
I0K14_14265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I0K14_14275	COG1280	lysine exporter protein (LysE YggA)
I0K14_14280	COG3403	YqcI/YcgG family
I0K14_14315	COG0778	Nitroreductase
I0K14_14320	COG1846	Transcriptional regulator
I0K14_14335	COG1051	belongs to the nudix hydrolase family
I0K14_14340	COG4884	unkown
I0K14_14340	COG3831	ATPase activity
I0K14_14365	COG0456	acetyltransferase
I0K14_14380	COG0697	spore germination
I0K14_14385	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_14435	COG0730	response to heat
I0K14_14445	COG0833	amino acid
I0K14_14455	COG4335	DNA alkylation repair
I0K14_14530	COG1984	allophanate hydrolase subunit 2
I0K14_14535	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I0K14_14540	COG1414	Transcriptional regulator
I0K14_14550	COG3142	Participates in the control of copper homeostasis
I0K14_14555	COG0860	N-Acetylmuramoyl-L-alanine amidase
I0K14_14560	COG0640	Transcriptional regulator
I0K14_14575	COG1960	acyl-CoA dehydrogenase activity
I0K14_14590	COG3314	Sporulation integral membrane protein YlbJ
I0K14_14610	COG3848	Pyruvate phosphate dikinase
I0K14_14610	COG0574	Belongs to the PEP-utilizing enzyme family
I0K14_14620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_14640	COG1063	alcohol dehydrogenase
I0K14_14650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I0K14_14655	COG0737	Belongs to the 5'-nucleotidase family
I0K14_14660	COG0753	catalase activity
I0K14_14665	COG0598	Magnesium transport protein CorA
I0K14_14710	COG0415	Belongs to the DNA photolyase family
I0K14_14715	COG0288	reversible hydration of carbon dioxide
I0K14_14725	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0K14_14730	COG5609	conserved protein (DUF2294)
I0K14_14745	COG0697	spore germination
I0K14_14755	COG1575	Belongs to the MenA family. Type 1 subfamily
I0K14_14760	COG4641	Protein conserved in bacteria
I0K14_14765	COG1136	(ABC) transporter
I0K14_14770	COG0577	efflux transmembrane transporter activity
I0K14_14805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_14815	COG3347	Dehydrogenase
I0K14_14815	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_14825	COG1070	Carbohydrate kinase
I0K14_14830	COG0235	Class ii aldolase
I0K14_14840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I0K14_14850	COG4154	Belongs to the RbsD FucU family
I0K14_14865	COG0798	PFAM Bile acid sodium symporter
I0K14_14870	COG0346	lactoylglutathione lyase activity
I0K14_14875	COG0640	Transcriptional regulator
I0K14_14885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I0K14_14900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0K14_14900	COG3320	Male sterility
I0K14_14905	COG1309	transcriptional regulator
I0K14_14915	COG2814	Major facilitator Superfamily
I0K14_14920	COG1309	transcriptional regulator
I0K14_14955	COG1522	sequence-specific DNA binding
I0K14_14970	COG0346	lactoylglutathione lyase activity
I0K14_14980	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_15020	COG2814	Major facilitator Superfamily
I0K14_15030	COG4895	conserved protein (DUF2196)
I0K14_15055	COG1280	lysine exporter protein (LysE YggA)
I0K14_15080	COG2515	1-aminocyclopropane-1-carboxylate deaminase
I0K14_15095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I0K14_15115	COG0577	efflux transmembrane transporter activity
I0K14_15135	COG3850	Histidine kinase
I0K14_15135	COG5002	protein histidine kinase activity
I0K14_15145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_15150	COG2271	Major facilitator Superfamily
I0K14_15155	COG1556	Lactate utilization protein
I0K14_15160	COG1139	Iron-sulfur cluster binding protein
I0K14_15170	COG0583	DNA-binding transcription factor activity
I0K14_15185	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K14_15200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I0K14_15220	COG0662	Cupin 2, conserved barrel domain protein
I0K14_15225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_15225	COG2207	Transcriptional regulator
I0K14_15240	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_15240	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K14_15270	COG0477	Major facilitator Superfamily
I0K14_15285	COG1846	Transcriptional regulator
I0K14_15290	COG2814	Major facilitator Superfamily
I0K14_15300	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K14_15305	COG1131	(ABC) transporter
I0K14_15325	COG2076	Multidrug Resistance protein
I0K14_15330	COG1309	transcriptional regulator
I0K14_15340	COG2031	fatty acid transporter
I0K14_15350	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_15385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I0K14_15400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I0K14_15405	COG1288	antiporter activity
I0K14_15430	COG0789	Transcriptional regulator
I0K14_15455	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I0K14_15480	COG1733	regulation of RNA biosynthetic process
I0K14_15485	COG0778	Nitroreductase
I0K14_15505	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_15515	COG1131	(ABC) transporter
I0K14_15540	COG1011	Hydrolase
I0K14_15550	COG2365	Tyrosine phosphatase family
I0K14_15570	COG0346	lactoylglutathione lyase activity
I0K14_15575	COG1940	carbohydrate kinase activity
I0K14_15580	COG0110	maltose O-acetyltransferase activity
I0K14_15595	COG0628	permease
I0K14_15615	COG2226	methyltransferase
I0K14_15625	COG0477	Major facilitator Superfamily
I0K14_15650	COG1253	flavin adenine dinucleotide binding
I0K14_15655	COG0789	Transcriptional regulator
I0K14_15695	COG0697	spore germination
I0K14_15705	COG1357	PFAM Pentapeptide repeats (8 copies)
I0K14_15710	COG3813	Protein conserved in bacteria
I0K14_15715	COG2706	6-phosphogluconolactonase activity
I0K14_15720	COG1070	Carbohydrate kinase
I0K14_15730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I0K14_15735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
I0K14_15745	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0K14_15750	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I0K14_15755	COG0604	alcohol dehydrogenase
I0K14_15760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I0K14_15770	COG0604	alcohol dehydrogenase
I0K14_15770	COG3321	synthase
I0K14_15775	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_15780	COG1733	regulation of RNA biosynthetic process
I0K14_15785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I0K14_15830	COG0656	L-ascorbic acid biosynthetic process
I0K14_15835	COG2814	Major facilitator Superfamily
I0K14_15850	COG0814	amino acid
I0K14_15875	COG1393	Belongs to the ArsC family
I0K14_15880	COG1733	regulation of RNA biosynthetic process
I0K14_15885	COG2188	Transcriptional regulator
I0K14_15890	COG0673	inositol 2-dehydrogenase activity
I0K14_15895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I0K14_15900	COG1733	regulation of RNA biosynthetic process
I0K14_15905	COG1733	regulation of RNA biosynthetic process
I0K14_15925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_15945	COG0384	phenazine biosynthesis protein PhzF
I0K14_15970	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_15975	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_15980	COG1733	regulation of RNA biosynthetic process
I0K14_16005	COG1191	sigma factor activity
I0K14_16025	COG1309	transcriptional regulator
I0K14_16065	COG1151	hydroxylamine reductase activity
I0K14_16075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_16110	COG2072	flavoprotein involved in K transport
I0K14_16155	COG1695	Transcriptional regulator
I0K14_16165	COG1113	amino acid transport
I0K14_16170	COG2814	Major facilitator Superfamily
I0K14_16195	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I0K14_16200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K14_16210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_16215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_16220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_16225	COG3739	integral membrane protein
I0K14_16260	COG0583	DNA-binding transcription factor activity
I0K14_16270	COG2890	protein-(glutamine-N5) methyltransferase activity
I0K14_16285	COG1193	negative regulation of DNA recombination
I0K14_16290	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I0K14_16295	COG1164	Oligoendopeptidase f
I0K14_16300	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I0K14_16330	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_16350	COG0640	Transcriptional regulator
I0K14_16355	COG0604	alcohol dehydrogenase
I0K14_16365	COG0457	Tetratricopeptide repeat
I0K14_16375	COG2808	Putative FMN-binding domain
I0K14_16380	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_16390	COG0385	Bile acid
I0K14_16395	COG0277	FAD linked oxidase domain protein
I0K14_16425	COG1285	pathogenesis
I0K14_16440	COG2514	catechol 2,3-dioxygenase activity
I0K14_16445	COG2720	vancomycin resistance protein
I0K14_16460	COG0210	DNA helicase
I0K14_16465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0K14_16485	COG0582	viral genome integration into host DNA
I0K14_16535	COG0582	viral genome integration into host DNA
I0K14_16570	COG0716	FMN binding
I0K14_16580	COG0494	nUDIX hydrolase
I0K14_16600	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_16610	COG0165	Argininosuccinate lyase
I0K14_16625	COG4145	pantothenate transmembrane transporter activity
I0K14_16635	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_16640	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_16650	COG1657	PFAM Prenyltransferase squalene oxidase
I0K14_16655	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
I0K14_16660	COG2962	Rard protein
I0K14_16665	COG3326	Membrane
I0K14_16680	COG0489	protein tyrosine kinase activity
I0K14_16690	COG0314	molybdopterin synthase activity
I0K14_16695	COG0303	'Molybdopterin
I0K14_16700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_16705	COG2116	formate transmembrane transporter activity
I0K14_16715	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I0K14_16720	COG5609	conserved protein (DUF2294)
I0K14_16725	COG2427	Protein of unknown function (DUF1641)
I0K14_16730	COG3383	formate dehydrogenase (NAD+) activity
I0K14_16735	COG0697	spore germination
I0K14_16780	COG2226	methyltransferase
I0K14_16785	COG4166	transmembrane transport
I0K14_16790	COG4166	transmembrane transport
I0K14_16795	COG4166	transmembrane transport
I0K14_16800	COG1301	dicarboxylic acid transport
I0K14_16805	COG1316	TRANSCRIPTIONal
I0K14_16825	COG1131	(ABC) transporter
I0K14_16835	COG0673	inositol 2-dehydrogenase activity
I0K14_16840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I0K14_16845	COG0187	DNA topoisomerase II activity
I0K14_16850	COG1832	CoA-binding protein
I0K14_16855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K14_16860	COG0745	RESPONSE REGULATOR receiver
I0K14_16880	COG4841	protein insertion into membrane
I0K14_16885	COG0824	Thioesterase
I0K14_16915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_16925	COG1132	(ABC) transporter
I0K14_16930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I0K14_16960	COG2211	Major facilitator Superfamily
I0K14_16970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I0K14_16985	COG0183	Belongs to the thiolase family
I0K14_16990	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_16995	COG1268	BioY protein
I0K14_17000	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_17015	COG1396	sequence-specific DNA binding
I0K14_17060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_17070	COG5002	protein histidine kinase activity
I0K14_17075	COG0400	carboxylic ester hydrolase activity
I0K14_17080	COG0346	lactoylglutathione lyase activity
I0K14_17085	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I0K14_17095	COG0069	glutamate synthase activity
I0K14_17100	COG1902	pentaerythritol trinitrate reductase activity
I0K14_17105	COG1329	Transcriptional regulator
I0K14_17110	COG0010	Belongs to the arginase family
I0K14_17135	COG2226	methyltransferase
I0K14_17175	COG3344	reverse transcriptase
I0K14_17185	COG4846	Membrane protein involved in cytochrome C biogenesis
I0K14_17190	COG0785	Cytochrome C biogenesis protein
I0K14_17200	COG1473	amidohydrolase
I0K14_17210	COG1131	(ABC) transporter
I0K14_17220	COG0583	DNA-binding transcription factor activity
I0K14_17230	COG1346	cytolysis
I0K14_17245	COG0730	response to heat
I0K14_17255	COG5632	N-Acetylmuramoyl-L-alanine amidase
I0K14_17255	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_17270	COG1132	(ABC) transporter
I0K14_17275	COG1132	(ABC) transporter
I0K14_17300	COG3639	organic phosphonate transmembrane transporter activity
I0K14_17305	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I0K14_17310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_17315	COG0737	Belongs to the 5'-nucleotidase family
I0K14_17325	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I0K14_17345	COG1695	Transcriptional regulator
I0K14_17350	COG0174	glutamine synthetase
I0K14_17355	COG0789	Transcriptional regulator
I0K14_17360	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
I0K14_17365	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I0K14_17370	COG2860	membrane
I0K14_17375	COG0464	growth
I0K14_17405	COG1388	LysM domain
I0K14_17405	COG3584	3D domain protein
I0K14_17410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0K14_17410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I0K14_17410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_17415	COG1105	Belongs to the carbohydrate kinase PfkB family
I0K14_17420	COG1349	DNA-binding transcription factor activity
I0K14_17425	COG1979	alcohol dehydrogenase
I0K14_17430	COG2322	membrane
I0K14_17440	COG1113	amino acid transport
I0K14_17450	COG1408	metallophosphoesterase
I0K14_17455	COG2116	formate transmembrane transporter activity
I0K14_17470	COG2217	Heavy metal translocating P-type atpase
I0K14_17475	COG2608	mercury ion transmembrane transporter activity
I0K14_17480	COG1937	Protein conserved in bacteria
I0K14_17490	COG1230	cation diffusion facilitator family transporter
I0K14_17510	COG2819	hydrolase of the alpha beta superfamily
I0K14_17515	COG1120	ATPase activity
I0K14_17520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_17525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_17530	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_17540	COG2169	Transcriptional regulator
I0K14_17545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I0K14_17550	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I0K14_17560	COG2364	Membrane
I0K14_17575	COG2267	carboxylic ester hydrolase activity
I0K14_17580	COG0346	lactoylglutathione lyase activity
I0K14_17585	COG5001	Diguanylate cyclase
I0K14_17585	COG3300	MHYT domain
I0K14_17620	COG0384	phenazine biosynthesis protein PhzF
I0K14_17630	COG1346	cytolysis
I0K14_17635	COG1380	Effector of murein hydrolase LrgA
I0K14_17640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I0K14_17660	COG1404	Belongs to the peptidase S8 family
I0K14_17665	COG3773	Cell wall hydrolase
I0K14_17675	COG1368	sulfuric ester hydrolase activity
I0K14_17680	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
I0K14_17690	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I0K14_17715	COG1131	(ABC) transporter
I0K14_17740	COG4550	Control of competence regulator ComK, YlbF/YmcA
I0K14_17750	COG1013	pyruvate-flavodoxin oxidoreductase activity
I0K14_17755	COG0674	pyruvate-flavodoxin oxidoreductase activity
I0K14_17755	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I0K14_17765	COG2359	stage V sporulation protein S
I0K14_17770	COG1692	metallophosphoesterase
I0K14_17775	COG1418	mRNA catabolic process
I0K14_17795	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I0K14_17800	COG1426	Protein conserved in bacteria
I0K14_17815	COG0300	oxidoreductase activity
I0K14_17820	COG0612	Peptidase, M16
I0K14_17825	COG0612	Peptidase, M16
I0K14_17830	COG1079	Belongs to the binding-protein-dependent transport system permease family
I0K14_17835	COG4603	Belongs to the binding-protein-dependent transport system permease family
I0K14_17840	COG3845	ABC transporter
I0K14_17845	COG1744	ABC transporter substrate-binding protein PnrA-like
I0K14_17850	COG2188	Transcriptional regulator
I0K14_17855	COG1674	ftsk spoiiie
I0K14_17865	COG0740	serine-type endopeptidase activity
I0K14_17870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K14_17880	COG0527	aspartate kinase activity
I0K14_17885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I0K14_17890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0K14_17895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K14_17900	COG1873	PFAM PRC-barrel domain
I0K14_17905	COG0612	Peptidase, M16
I0K14_17910	COG0726	polysaccharide deacetylase
I0K14_17925	COG0196	riboflavin kinase activity
I0K14_17940	COG1550	Protein conserved in bacteria
I0K14_17950	COG1358	cellular component organization or biogenesis
I0K14_17955	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I0K14_17960	COG0195	Participates in both transcription termination and antitermination
I0K14_17980	COG0750	zinc metalloprotease
I0K14_17990	COG4589	Belongs to the CDS family
I0K14_18005	COG0528	UMP kinase activity
I0K14_18035	COG4974	Belongs to the 'phage' integrase family
I0K14_18045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I0K14_18050	COG0758	DNA mediated transformation
I0K14_18055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I0K14_18095	COG1837	Belongs to the UPF0109 family
I0K14_18105	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I0K14_18115	COG0552	protein localization to endoplasmic reticulum
I0K14_18120	COG1196	nuclear chromosome segregation
I0K14_18130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I0K14_18135	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_18140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I0K14_18155	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I0K14_18160	COG1461	Dihydroxyacetone kinase
I0K14_18165	COG1302	Protein conserved in bacteria
I0K14_18180	COG1564	THIamine pyrophosphokinase
I0K14_18185	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I0K14_18195	COG0515	serine threonine protein kinase
I0K14_18195	COG2815	serine threonine protein kinase
I0K14_18200	COG0631	protein serine/threonine phosphatase activity
I0K14_18210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I0K14_18210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I0K14_18220	COG0242	peptide deformylase activity
I0K14_18225	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I0K14_18230	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I0K14_18250	COG1561	YicC-like family, N-terminal region
I0K14_18255	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I0K14_18270	COG0006	proline dipeptidase activity
I0K14_18290	COG3069	C4-dicarboxylate transmembrane transporter activity
I0K14_18350	COG0564	pseudouridine synthase activity
I0K14_18375	COG2302	S4 RNA-binding domain
I0K14_18380	COG0762	integral membrane protein
I0K14_18390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I0K14_18400	COG1873	PFAM PRC-barrel domain
I0K14_18405	COG1191	sigma factor activity
I0K14_18410	COG1191	sigma factor activity
I0K14_18420	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I0K14_18425	COG0849	cell division
I0K14_18430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I0K14_18445	COG0772	Belongs to the SEDS family
I0K14_18460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I0K14_18465	COG0768	penicillin binding
I0K14_18470	COG0768	penicillin binding
I0K14_18475	COG4839	cell division protein FtsL
I0K14_18490	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I0K14_18505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I0K14_18510	COG1399	metal-binding, possibly nucleic acid-binding protein
I0K14_18520	COG3480	Lon protease (S16) C-terminal proteolytic domain
I0K14_18525	COG1752	Esterase of the alpha-beta hydrolase superfamily
I0K14_18530	COG3314	Sporulation integral membrane protein YlbJ
I0K14_18540	COG0742	ribosomal rna small subunit methyltransferase
I0K14_18555	COG3679	Belongs to the UPF0342 family
I0K14_18560	COG0406	alpha-ribazole phosphatase activity
I0K14_18575	COG2340	Cysteine-rich secretory protein family
I0K14_18590	COG3336	cytochrome c oxidase
I0K14_18625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I0K14_18630	COG0772	Belongs to the SEDS family
I0K14_18640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I0K14_18645	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I0K14_18655	COG4896	Protein conserved in bacteria
I0K14_18670	COG1217	gtp-binding protein TYPA
I0K14_18680	COG0483	inositol monophosphate 1-phosphatase activity
I0K14_18700	COG1982	Orn Lys Arg decarboxylase major
I0K14_18750	COG0022	dehydrogenase e1 component
I0K14_18755	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K14_18765	COG0242	peptide deformylase activity
I0K14_18770	COG0561	phosphatase activity
I0K14_18780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I0K14_18785	COG0569	domain protein
I0K14_18805	COG0583	DNA-binding transcription factor activity
I0K14_18810	COG0517	IMP dehydrogenase activity
I0K14_18820	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
I0K14_18830	COG4703	Protein of unknown function (DUF1797)
I0K14_18845	COG2200	EAL domain
I0K14_18850	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_18855	COG1408	metallophosphoesterase
I0K14_18865	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I0K14_18900	COG2814	Major facilitator Superfamily
I0K14_18925	COG3209	COG3209 Rhs family protein
I0K14_18935	COG2205	protein histidine kinase activity
I0K14_18945	COG0436	Aminotransferase
I0K14_18950	COG1609	Transcriptional regulator
I0K14_18955	COG3833	ABC-type maltose transport systems, permease component
I0K14_18960	COG1175	transmembrane transport
I0K14_18965	COG2182	Extracellular solute-binding protein
I0K14_18975	COG0366	Alpha amylase catalytic
I0K14_18980	COG3842	ATPase activity
I0K14_19020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I0K14_19025	COG0183	Belongs to the thiolase family
I0K14_19060	COG1695	Transcriptional regulator
I0K14_19065	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_19085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I0K14_19090	COG0436	Aminotransferase
I0K14_19125	COG2084	Dehydrogenase
I0K14_19135	COG2199	diguanylate cyclase activity
I0K14_19140	COG0778	Nitroreductase
I0K14_19165	COG1263	PTS System
I0K14_19165	COG2190	(PTS) system
I0K14_19165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I0K14_19170	COG3711	transcriptional antiterminator
I0K14_19180	COG2188	Transcriptional regulator
I0K14_19190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I0K14_19215	COG1547	Domain of unknown function (DUF309)
I0K14_19220	COG0456	acetyltransferase
I0K14_19225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I0K14_19230	COG4086	secreted protein
I0K14_19235	COG0561	phosphatase activity
I0K14_19240	COG0697	spore germination
I0K14_19255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_19280	COG0733	neurotransmitter:sodium symporter activity
I0K14_19300	COG1686	Belongs to the peptidase S11 family
I0K14_19305	COG1725	Transcriptional regulator
I0K14_19310	COG1131	(ABC) transporter
I0K14_19330	COG1846	Transcriptional regulator
I0K14_19345	COG0598	Magnesium transport protein CorA
I0K14_19370	COG4974	Belongs to the 'phage' integrase family
I0K14_19380	COG0735	belongs to the Fur family
I0K14_19385	COG1300	Membrane
I0K14_19405	COG0667	Aldo Keto reductase
I0K14_19410	COG0656	L-ascorbic acid biosynthetic process
I0K14_19415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
I0K14_19415	COG0456	acetyltransferase
I0K14_19425	COG0737	Belongs to the 5'-nucleotidase family
I0K14_19425	COG1525	nuclease
I0K14_19425	COG4085	toxin activity
I0K14_19435	COG0596	Alpha beta hydrolase
I0K14_19440	COG2056	Na+-H+ antiporter family
I0K14_19445	COG1609	Transcriptional regulator
I0K14_19450	COG0456	acetyltransferase
I0K14_19455	COG1073	alpha beta
I0K14_19470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K14_19470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I0K14_19475	COG0307	riboflavin synthase, alpha
I0K14_19500	COG4106	trans-aconitate 2-methyltransferase activity
I0K14_19505	COG2226	methyltransferase
I0K14_19505	COG1073	alpha beta
I0K14_19520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I0K14_19530	COG1757	Na H antiporter
I0K14_19535	COG0737	Belongs to the 5'-nucleotidase family
I0K14_19545	COG1522	sequence-specific DNA binding
I0K14_19580	COG5444	nuclease activity
I0K14_19590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I0K14_19615	COG0300	oxidoreductase activity
I0K14_19620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_19625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_19630	COG1760	l-serine dehydratase
I0K14_19635	COG1760	l-serine dehydratase
I0K14_19660	COG1285	pathogenesis
I0K14_19675	COG2195	Cleaves the N-terminal amino acid of tripeptides
I0K14_19680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_19695	COG1376	ErfK ybiS ycfS ynhG family protein
I0K14_19700	COG4129	membrane
I0K14_19705	COG1126	abc transporter atp-binding protein
I0K14_19710	COG0765	amino acid transport
I0K14_19715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I0K14_19730	COG2323	membrane
I0K14_19735	COG0772	Belongs to the SEDS family
I0K14_19740	COG0508	dehydrogenase complex catalyzes the overall conversion of
I0K14_19745	COG0022	dehydrogenase e1 component
I0K14_19750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I0K14_19755	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I0K14_19770	COG0280	phosphate acetyltransferase
I0K14_19775	COG3829	transcription factor binding
I0K14_19775	COG3290	protein histidine kinase activity
I0K14_19785	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_19790	COG3093	addiction module antidote protein HigA
I0K14_19795	COG0745	RESPONSE REGULATOR receiver
I0K14_19800	COG0750	zinc metalloprotease
I0K14_19805	COG0497	DNA recombination
I0K14_19815	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I0K14_19825	COG0142	geranyltranstransferase activity
I0K14_19850	COG1302	Protein conserved in bacteria
I0K14_19855	COG0439	Biotin carboxylase
I0K14_19860	COG0511	ligase activity, forming carbon-carbon bonds
I0K14_19905	COG3854	ATPases associated with a variety of cellular activities
I0K14_19930	COG0006	proline dipeptidase activity
I0K14_19945	COG3872	metal-dependent enzyme
I0K14_19955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I0K14_19975	COG0095	Lipoate-protein ligase
I0K14_19980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_19985	COG1609	Transcriptional regulator
I0K14_19995	COG2076	Multidrug Resistance protein
I0K14_20000	COG2076	Multidrug Resistance protein
I0K14_20035	COG1131	(ABC) transporter
I0K14_20040	COG1725	Transcriptional regulator
I0K14_20070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K14_20125	COG4970	Tfp pilus assembly protein FimT
I0K14_20135	COG1459	type II secretion system
I0K14_20140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I0K14_20190	COG1410	methionine synthase
I0K14_20190	COG0646	methionine synthase
I0K14_20195	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I0K14_20195	COG0646	methionine synthase
I0K14_20200	COG0626	cystathionine gamma-synthase activity
I0K14_20205	COG0626	cystathionine gamma-synthase activity
I0K14_20225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_20235	COG1940	carbohydrate kinase activity
I0K14_20240	COG4483	Protein conserved in bacteria
I0K14_20245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I0K14_20250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I0K14_20255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
I0K14_20260	COG0704	Plays a role in the regulation of phosphate uptake
I0K14_20270	COG0581	inorganic phosphate transmembrane transporter activity
I0K14_20275	COG0573	inorganic phosphate transmembrane transporter activity
I0K14_20280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I0K14_20285	COG0768	penicillin binding
I0K14_20290	COG0477	Major facilitator Superfamily
I0K14_20295	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K14_20320	COG0735	belongs to the Fur family
I0K14_20325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I0K14_20330	COG1121	(ABC) transporter
I0K14_20335	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_20365	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0K14_20370	COG2384	SAM-dependent methyltransferase
I0K14_20380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I0K14_20385	COG0358	DNA primase activity
I0K14_20395	COG0517	IMP dehydrogenase activity
I0K14_20410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I0K14_20415	COG0295	cytidine deaminase activity
I0K14_20420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I0K14_20430	COG1480	7TM receptor with intracellular HD hydrolase
I0K14_20435	COG1702	phosphate starvation-inducible protein PhoH
I0K14_20450	COG1610	YqeY-like protein
I0K14_20455	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I0K14_20460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I0K14_20465	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I0K14_20495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I0K14_20500	COG1733	regulation of RNA biosynthetic process
I0K14_20525	COG1466	dna polymerase III delta subunit
I0K14_20535	COG0658	competence protein
I0K14_20535	COG2333	competence protein COMEC
I0K14_20540	COG2131	deaminase
I0K14_20545	COG1596	polysaccharide export
I0K14_20545	COG1555	photosystem II stabilization
I0K14_20550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I0K14_20555	COG2226	methyltransferase
I0K14_20560	COG0799	negative regulation of ribosome biogenesis
I0K14_20565	COG1713	HD superfamily hydrolase involved in NAD metabolism
I0K14_20575	COG1534	Rna-binding protein
I0K14_20585	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I0K14_20590	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I0K14_20625	COG0778	Nitroreductase
I0K14_20630	COG2357	RelA SpoT domain protein
I0K14_20640	COG1785	Belongs to the alkaline phosphatase family
I0K14_20650	COG2267	carboxylic ester hydrolase activity
I0K14_20685	COG1404	Belongs to the peptidase S8 family
I0K14_20690	COG3186	Phenylalanine-4-hydroxylase
I0K14_20700	COG2514	catechol 2,3-dioxygenase activity
I0K14_20705	COG2259	Doxx family
I0K14_20745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I0K14_20755	COG1012	belongs to the aldehyde dehydrogenase family
I0K14_20755	COG1454	alcohol dehydrogenase
I0K14_20760	COG0626	cystathionine gamma-synthase activity
I0K14_20765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I0K14_20790	COG0768	penicillin binding
I0K14_20805	COG0826	peptidase U32
I0K14_20810	COG0826	peptidase U32
I0K14_20815	COG4122	O-methyltransferase activity
I0K14_20820	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I0K14_20850	COG0628	permease
I0K14_20870	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I0K14_20885	COG1104	cysteine desulfurase activity
I0K14_20890	COG1959	2 iron, 2 sulfur cluster binding
I0K14_20895	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I0K14_20905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I0K14_20935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I0K14_20945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0K14_20945	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I0K14_20950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I0K14_20955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0K14_20955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I0K14_20965	COG2244	polysaccharide biosynthetic process
I0K14_20970	COG2323	membrane
I0K14_20980	COG1862	Preprotein translocase
I0K14_21010	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
I0K14_21020	COG0697	spore germination
I0K14_21025	COG0640	Transcriptional regulator
I0K14_21050	COG0157	Belongs to the NadC ModD family
I0K14_21055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I0K14_21060	COG1104	cysteine desulfurase activity
I0K14_21065	COG1827	regulation of RNA biosynthetic process
I0K14_21070	COG2258	MOSC domain
I0K14_21075	COG0077	Prephenate dehydratase
I0K14_21080	COG0577	efflux transmembrane transporter activity
I0K14_21085	COG0577	efflux transmembrane transporter activity
I0K14_21090	COG1136	(ABC) transporter
I0K14_21095	COG5002	protein histidine kinase activity
I0K14_21100	COG0745	RESPONSE REGULATOR receiver
I0K14_21110	COG3290	protein histidine kinase activity
I0K14_21120	COG2868	ribosomal protein
I0K14_21125	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I0K14_21130	COG1530	ribonuclease E activity
I0K14_21135	COG1994	Peptidase M50
I0K14_21140	COG0739	heme binding
I0K14_21145	COG2894	cell division
I0K14_21165	COG1077	Cell shape determining protein MreB Mrl
I0K14_21185	COG0285	dihydrofolate synthase activity
I0K14_21200	COG1388	LysM domain
I0K14_21210	COG0113	porphobilinogen synthase activity
I0K14_21215	COG1587	Uroporphyrinogen-III synthase
I0K14_21225	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I0K14_21235	COG1846	Transcriptional regulator
I0K14_21240	COG1764	response to oxidative stress
I0K14_21255	COG0470	DNA polymerase III
I0K14_21255	COG1067	ATP-dependent peptidase activity
I0K14_21300	COG0622	Phosphoesterase
I0K14_21315	COG5401	PFAM Sporulation and spore germination
I0K14_21325	COG2814	Major facilitator Superfamily
I0K14_21335	COG1309	transcriptional regulator
I0K14_21345	COG2197	response regulator
I0K14_21360	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I0K14_21360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I0K14_21370	COG0497	DNA recombination
I0K14_21425	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I0K14_21445	COG2197	response regulator
I0K14_21450	COG2233	PERMEase
I0K14_21460	COG0402	S-adenosylhomocysteine deaminase activity
I0K14_21465	COG0402	S-adenosylhomocysteine deaminase activity
I0K14_21475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I0K14_21485	COG0444	Belongs to the ABC transporter superfamily
I0K14_21490	COG4608	Belongs to the ABC transporter superfamily
I0K14_21495	COG3275	phosphorelay sensor kinase activity
I0K14_21500	COG3279	Response regulator of the LytR AlgR family
I0K14_21510	COG1983	PspC domain protein
I0K14_21515	COG1396	sequence-specific DNA binding
I0K14_21520	COG0697	spore germination
I0K14_21530	COG1959	2 iron, 2 sulfur cluster binding
I0K14_21535	COG1668	transmembrane transport
I0K14_21540	COG4152	abc transporter atp-binding protein
I0K14_21545	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
I0K14_21550	COG1360	Flagellar Motor Protein
I0K14_21555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I0K14_21560	COG1876	peptidase activity
I0K14_21565	COG0824	Thioesterase
I0K14_21570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I0K14_21575	COG1053	succinate dehydrogenase
I0K14_21580	COG2009	succinate dehydrogenase
I0K14_21585	COG1719	4-vinyl reductase, 4VR
I0K14_21595	COG3118	belongs to the thioredoxin family
I0K14_21600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I0K14_21605	COG2086	electron transfer activity
I0K14_21610	COG1024	Enoyl-CoA hydratase
I0K14_21615	COG1309	transcriptional regulator
I0K14_21620	COG0318	PFAM AMP-dependent synthetase and ligase
I0K14_21630	COG2318	DinB family
I0K14_21655	COG1131	(ABC) transporter
I0K14_21660	COG2205	protein histidine kinase activity
I0K14_21665	COG0745	RESPONSE REGULATOR receiver
I0K14_21675	COG4895	conserved protein (DUF2196)
I0K14_21680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I0K14_21695	COG4509	Sortase family
I0K14_21700	COG1120	ATPase activity
I0K14_21715	COG5386	Cell surface protein
I0K14_21720	COG5386	Cell surface protein
I0K14_21725	COG1114	Component of the transport system for branched-chain amino acids
I0K14_21730	COG1187	pseudouridine synthase activity
I0K14_21740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I0K14_21740	COG1796	DNA polymerase
I0K14_21745	COG1286	toxin biosynthetic process
I0K14_21790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I0K14_21800	COG1418	mRNA catabolic process
I0K14_21835	COG2814	Major facilitator Superfamily
I0K14_21840	COG1566	PFAM secretion protein HlyD family protein
I0K14_21845	COG1309	transcriptional regulator
I0K14_21850	COG1363	Peptidase, m42
I0K14_21875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I0K14_21885	COG1484	DNA-dependent DNA replication
I0K14_21890	COG3611	Membrane attachment protein
I0K14_21900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
I0K14_21905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0K14_21910	COG0237	dephospho-CoA kinase activity
I0K14_21915	COG1971	Probably functions as a manganese efflux pump
I0K14_21925	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K14_21925	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I0K14_21930	COG5002	protein histidine kinase activity
I0K14_21935	COG0745	RESPONSE REGULATOR receiver
I0K14_21950	COG0538	isocitrate dehydrogenase activity
I0K14_21955	COG0372	Belongs to the citrate synthase family
I0K14_21965	COG0628	permease
I0K14_21970	COG3030	protein affecting phage T7 exclusion by the F plasmid
I0K14_21995	COG1725	Transcriptional regulator
I0K14_22000	COG0281	malic enzyme
I0K14_22005	COG0587	DNA-directed DNA polymerase activity
I0K14_22020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I0K14_22035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K14_22045	COG4109	DRTGG domain
I0K14_22060	COG0006	proline dipeptidase activity
I0K14_22090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_22095	COG0662	Cupin 2, conserved barrel domain protein
I0K14_22140	COG1028	Short-chain dehydrogenase reductase Sdr
I0K14_22145	COG0589	response to stress
I0K14_22190	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_22215	COG0827	DNA restriction-modification system
I0K14_22220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I0K14_22225	COG3874	Sporulation protein YtfJ
I0K14_22240	COG1574	metal-dependent hydrolase with the TIM-barrel fold
I0K14_22250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K14_22265	COG1104	cysteine desulfurase activity
I0K14_22275	COG0583	DNA-binding transcription factor activity
I0K14_22280	COG0697	spore germination
I0K14_22285	COG1309	transcriptional regulator
I0K14_22290	COG1956	GAF domain-containing protein
I0K14_22295	COG0626	cystathionine gamma-synthase activity
I0K14_22325	COG1595	DNA-templated transcription, initiation
I0K14_22340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I0K14_22345	COG0454	-acetyltransferase
I0K14_22350	COG0517	IMP dehydrogenase activity
I0K14_22355	COG0123	including yeast histone deacetylase and acetoin utilization protein
I0K14_22370	COG0745	RESPONSE REGULATOR receiver
I0K14_22380	COG0666	response to abiotic stimulus
I0K14_22420	COG1609	Transcriptional regulator
I0K14_22425	COG4851	CamS sex pheromone cAM373 precursor
I0K14_22430	COG3118	belongs to the thioredoxin family
I0K14_22440	COG2309	aminopeptidase activity
I0K14_22460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_22465	COG0697	spore germination
I0K14_22470	COG0789	Transcriptional regulator
I0K14_22475	COG1695	Transcriptional regulator
I0K14_22495	COG1674	ftsk spoiiie
I0K14_22505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I0K14_22515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_22520	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
I0K14_22525	COG1363	Peptidase, m42
I0K14_22535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_22550	COG0510	thiamine kinase activity
I0K14_22555	COG1523	belongs to the glycosyl hydrolase 13 family
I0K14_22565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I0K14_22570	COG1349	DNA-binding transcription factor activity
I0K14_22575	COG1187	pseudouridine synthase activity
I0K14_22580	COG2244	polysaccharide biosynthetic process
I0K14_22585	COG2081	HI0933 family
I0K14_22590	COG2814	Major facilitator Superfamily
I0K14_22600	COG3832	glyoxalase III activity
I0K14_22620	COG1329	Transcriptional regulator
I0K14_22645	COG0314	molybdopterin synthase activity
I0K14_22650	COG1763	Mo-molybdopterin cofactor biosynthetic process
I0K14_22655	COG0303	'Molybdopterin
I0K14_22665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I0K14_22670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I0K14_22690	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I0K14_22700	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I0K14_22740	COG2814	Major facilitator Superfamily
I0K14_22745	COG0475	glutathione-regulated potassium exporter activity
I0K14_22750	COG0490	domain, Protein
I0K14_22755	COG0582	viral genome integration into host DNA
I0K14_22765	COG1136	(ABC) transporter
I0K14_22785	COG1242	4 iron, 4 sulfur cluster binding
I0K14_22790	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I0K14_22805	COG1794	racemase activity, acting on amino acids and derivatives
I0K14_22830	COG2267	carboxylic ester hydrolase activity
I0K14_22835	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I0K14_22840	COG0671	phosphoesterase, PA-phosphatase related
I0K14_22845	COG0438	transferase activity, transferring glycosyl groups
I0K14_22855	COG0521	Mo-molybdopterin cofactor biosynthetic process
I0K14_22900	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I0K14_22905	COG0546	phosphoglycolate phosphatase activity
I0K14_22910	COG1349	DNA-binding transcription factor activity
I0K14_22920	COG5002	protein histidine kinase activity
I0K14_22925	COG4191	Histidine kinase
I0K14_22930	COG2267	carboxylic ester hydrolase activity
I0K14_22935	COG1368	sulfuric ester hydrolase activity
I0K14_22955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I0K14_22960	COG1116	anion transmembrane transporter activity
I0K14_22965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I0K14_22990	COG0494	nUDIX hydrolase
I0K14_23020	COG0288	reversible hydration of carbon dioxide
I0K14_23025	COG1271	oxidase subunit
I0K14_23030	COG1294	oxidase, subunit
I0K14_23050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_23075	COG1842	Phage shock protein A
I0K14_23110	COG5002	protein histidine kinase activity
I0K14_23115	COG0745	RESPONSE REGULATOR receiver
I0K14_23145	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I0K14_23150	COG1597	lipid kinase activity
I0K14_23165	COG0577	efflux transmembrane transporter activity
I0K14_23170	COG1136	(ABC) transporter
I0K14_23195	COG0586	Pfam SNARE associated Golgi protein
I0K14_23205	COG4977	sequence-specific DNA binding
I0K14_23215	COG0577	efflux transmembrane transporter activity
I0K14_23220	COG1136	(ABC) transporter
I0K14_23225	COG2207	Transcriptional regulator
I0K14_23225	COG3708	Transcriptional regulator
I0K14_23230	COG5658	integral membrane protein
I0K14_23235	COG0640	Transcriptional regulator
I0K14_23240	COG0745	RESPONSE REGULATOR receiver
I0K14_23245	COG2205	protein histidine kinase activity
I0K14_23250	COG0577	efflux transmembrane transporter activity
I0K14_23255	COG0577	efflux transmembrane transporter activity
I0K14_23260	COG1136	(ABC) transporter
I0K14_23265	COG0577	efflux transmembrane transporter activity
I0K14_23290	COG2188	Transcriptional regulator
I0K14_23310	COG3964	amidohydrolase
I0K14_23330	COG4948	Mandelate Racemase Muconate Lactonizing
I0K14_23340	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I0K14_23345	COG0596	Alpha beta hydrolase
I0K14_23355	COG1169	isochorismate synthase
I0K14_23360	COG1575	Belongs to the MenA family. Type 1 subfamily
I0K14_23365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I0K14_23385	COG0058	SHG alpha-glucan phosphorylase activity
I0K14_23395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I0K14_23415	COG1404	Belongs to the peptidase S8 family
I0K14_23515	COG0544	peptidyl-prolyl cis-trans isomerase activity
I0K14_23550	COG1285	pathogenesis
I0K14_23555	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0K14_23570	COG2155	Conserved Protein
I0K14_23575	COG1098	S1 RNA binding domain
I0K14_23580	COG0436	Aminotransferase
I0K14_23585	COG1522	sequence-specific DNA binding
I0K14_23590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I0K14_23595	COG2267	carboxylic ester hydrolase activity
I0K14_23605	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I0K14_23625	COG5018	Exonuclease
I0K14_23630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K14_23650	COG2050	protein possibly involved in aromatic compounds catabolism
I0K14_23660	COG1268	BioY protein
I0K14_23665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0K14_23670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I0K14_23685	COG3584	3D domain protein
I0K14_23700	COG1252	NADH dehydrogenase
I0K14_23710	COG3708	Transcriptional regulator
I0K14_23725	COG1683	Conserved Protein
I0K14_23740	COG0316	Belongs to the HesB IscA family
I0K14_23755	COG1252	NADH dehydrogenase
I0K14_23765	COG2274	protein secretion by the type I secretion system
I0K14_23770	COG0390	transport system, permease component
I0K14_23775	COG2824	Alkylphosphonate utilization operon protein PhnA
I0K14_23815	COG4837	Protein of unknown function (DUF1462)
I0K14_23820	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
I0K14_23830	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I0K14_23835	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I0K14_23845	COG2249	NAD(P)H dehydrogenase (quinone) activity
I0K14_23855	COG0647	UMP catabolic process
I0K14_23865	COG2445	Protein of unknown function DUF86
I0K14_23870	COG1494	fructose-1,6-bisphosphatase
I0K14_23885	COG4470	Protein conserved in bacteria
I0K14_23895	COG0789	Transcriptional regulator
I0K14_23900	COG4377	Putative membrane peptidase family (DUF2324)
I0K14_23925	COG0739	heme binding
I0K14_23935	COG3377	Domain of unknown function (DUF1805)
I0K14_23940	COG0737	Belongs to the 5'-nucleotidase family
I0K14_23945	COG0719	Fe-S assembly protein
I0K14_23950	COG0822	iron-sulfur transferase activity
I0K14_23955	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I0K14_23960	COG0719	Fe-S assembly protein
I0K14_23965	COG0396	ATPase activity
I0K14_23970	COG1464	Belongs to the NlpA lipoprotein family
I0K14_23975	COG1464	Belongs to the NlpA lipoprotein family
I0K14_23980	COG2011	ABC-type metal ion transport system permease component
I0K14_23995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I0K14_24000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I0K14_24010	COG1393	Belongs to the ArsC family
I0K14_24055	COG1309	transcriptional regulator
I0K14_24060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I0K14_24065	COG1960	acyl-CoA dehydrogenase activity
I0K14_24070	COG0183	Belongs to the thiolase family
I0K14_24075	COG1024	Enoyl-CoA hydratase
I0K14_24075	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0K14_24085	COG1686	Belongs to the peptidase S11 family
I0K14_24115	COG0011	TIGRFAM Protein of
I0K14_24120	COG0840	transmembrane signaling receptor activity
I0K14_24145	COG2814	Major facilitator Superfamily
I0K14_24150	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I0K14_24160	COG0531	amino acid
I0K14_24185	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I0K14_24220	COG0586	Pfam SNARE associated Golgi protein
I0K14_24230	COG1376	ErfK ybiS ycfS ynhG family protein
I0K14_24235	COG0745	RESPONSE REGULATOR receiver
I0K14_24240	COG5002	protein histidine kinase activity
I0K14_24265	COG0840	transmembrane signaling receptor activity
I0K14_24270	COG2151	metal-sulfur cluster biosynthetic enzyme
I0K14_24275	COG3227	Zinc metalloprotease (Elastase)
I0K14_24280	COG1741	Belongs to the pirin family
I0K14_24295	COG0475	glutathione-regulated potassium exporter activity
I0K14_24300	COG0490	domain, Protein
I0K14_24305	COG1115	amino acid carrier protein
I0K14_24310	COG0783	Belongs to the Dps family
I0K14_24325	COG1611	Belongs to the LOG family
I0K14_24345	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_24350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_24355	COG1115	amino acid carrier protein
I0K14_24360	COG1115	amino acid carrier protein
I0K14_24365	COG2910	NAD(P)H-binding
I0K14_24380	COG0656	L-ascorbic acid biosynthetic process
I0K14_24385	COG2814	Major facilitator Superfamily
I0K14_24390	COG1733	regulation of RNA biosynthetic process
I0K14_24400	COG1252	NADH dehydrogenase
I0K14_24405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I0K14_24420	COG3290	protein histidine kinase activity
I0K14_24420	COG0840	transmembrane signaling receptor activity
I0K14_24430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I0K14_24445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I0K14_24490	COG5002	protein histidine kinase activity
I0K14_24495	COG0745	RESPONSE REGULATOR receiver
I0K14_24500	COG1136	(ABC) transporter
I0K14_24520	COG1136	(ABC) transporter
I0K14_24555	COG0557	exoribonuclease II activity
I0K14_24560	COG1647	Serine aminopeptidase, S33
I0K14_24565	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I0K14_24570	COG1346	cytolysis
I0K14_24605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I0K14_24620	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I0K14_24645	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I0K14_24660	COG2323	membrane
I0K14_24670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I0K14_24680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I0K14_24690	COG1051	belongs to the nudix hydrolase family
I0K14_24700	COG0492	ferredoxin-NADP+ reductase activity
I0K14_24705	COG0457	Tetratricopeptide repeat
I0K14_24710	COG0110	maltose O-acetyltransferase activity
I0K14_24730	COG1950	PFAM Membrane protein of
I0K14_24740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I0K14_24755	COG0789	Transcriptional regulator
I0K14_24785	COG0583	DNA-binding transcription factor activity
I0K14_24795	COG0655	NAD(P)H dehydrogenase (quinone) activity
I0K14_24800	COG0488	(ABC) transporter
I0K14_24810	COG1132	(ABC) transporter
I0K14_24815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K14_24820	COG0793	Belongs to the peptidase S41A family
I0K14_24820	COG3409	Peptidoglycan-binding domain 1 protein
I0K14_24825	COG2177	Part of the ABC transporter FtsEX involved in
I0K14_24830	COG2884	Cell division ATP-binding protein ftsE
I0K14_24850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I0K14_24855	COG1278	Cold shock
I0K14_24860	COG1040	competence protein
I0K14_24865	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I0K14_24870	COG0791	NLP P60 protein
I0K14_24875	COG1733	regulation of RNA biosynthetic process
I0K14_24880	COG1307	EDD domain protein, DegV family
I0K14_24885	COG1739	Uncharacterized protein family UPF0029
I0K14_24890	COG1316	TRANSCRIPTIONal
I0K14_24895	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I0K14_24900	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I0K14_24905	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I0K14_24915	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I0K14_24915	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I0K14_24935	COG1486	melibiose metabolic process
I0K14_24940	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K14_24945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K14_24965	COG1447	Phosphotransferase system cellobiose-specific component IIA
I0K14_24975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I0K14_24980	COG1301	dicarboxylic acid transport
I0K14_24995	COG1511	domain protein
I0K14_25000	COG0583	DNA-binding transcription factor activity
I0K14_25005	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I0K14_25015	COG1271	oxidase subunit
I0K14_25020	COG1294	oxidase, subunit
I0K14_25025	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I0K14_25035	COG1620	l-lactate permease
I0K14_25045	COG2389	metal-binding protein
I0K14_25055	COG1368	sulfuric ester hydrolase activity
I0K14_25065	COG0791	NLP P60 protein
I0K14_25065	COG1388	LysM domain
I0K14_25070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I0K14_25080	COG1215	transferase activity, transferring glycosyl groups
I0K14_25085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K14_25090	COG3584	3D domain protein
I0K14_25090	COG1388	LysM domain
I0K14_25115	COG4715	Zinc finger, swim domain protein
I0K14_25120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I0K14_25165	COG0577	efflux transmembrane transporter activity
I0K14_25170	COG1136	(ABC) transporter
I0K14_25195	COG3850	Histidine kinase
I0K14_25195	COG5002	protein histidine kinase activity
I0K14_25200	COG0745	RESPONSE REGULATOR receiver
I0K14_25205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0K14_25215	COG1316	TRANSCRIPTIONal
I0K14_25225	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I0K14_25250	COG0438	transferase activity, transferring glycosyl groups
I0K14_25260	COG1215	transferase activity, transferring glycosyl groups
I0K14_25265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I0K14_25270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I0K14_25275	COG1086	Polysaccharide biosynthesis protein
I0K14_25280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I0K14_25285	COG4464	protein tyrosine phosphatase activity
I0K14_25290	COG0489	protein tyrosine kinase activity
I0K14_25295	COG3944	biosynthesis protein
I0K14_25300	COG0489	protein tyrosine kinase activity
I0K14_25315	COG1609	Transcriptional regulator
I0K14_25325	COG0739	heme binding
I0K14_25340	COG3279	Response regulator of the LytR AlgR family
I0K14_25345	COG2385	sporulation resulting in formation of a cellular spore
I0K14_25360	COG4836	Membrane
I0K14_25365	COG1007	ATP synthesis coupled electron transport
I0K14_25370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0K14_25375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I0K14_25385	COG0839	Belongs to the complex I subunit 6 family
I0K14_25405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I0K14_25420	COG3300	MHYT domain
I0K14_25420	COG5001	Diguanylate cyclase
I0K14_25470	COG0356	it plays a direct role in the translocation of protons across the membrane
I0K14_25505	COG0698	ribose 5-phosphate isomerase
I0K14_25515	COG2190	(PTS) system
I0K14_25520	COG2259	Doxx family
I0K14_25525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I0K14_25545	COG0009	L-threonylcarbamoyladenylate synthase
I0K14_25560	COG2890	protein-(glutamine-N5) methyltransferase activity
I0K14_25580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I0K14_25585	COG1494	fructose-1,6-bisphosphatase
I0K14_25605	COG4821	SIS domain
I0K14_25625	COG1960	acyl-CoA dehydrogenase activity
I0K14_25630	COG1960	acyl-CoA dehydrogenase activity
I0K14_25635	COG1250	3-hydroxyacyl-CoA dehydrogenase
I0K14_25640	COG0183	Belongs to the thiolase family
I0K14_25645	COG2181	nitrate reductase activity
I0K14_25645	COG0247	lactate metabolic process
I0K14_25650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I0K14_25660	COG3300	MHYT domain
I0K14_25660	COG5001	Diguanylate cyclase
I0K14_25680	COG2197	response regulator
I0K14_25685	COG4585	Histidine kinase
I0K14_25690	COG0842	Transport permease protein
I0K14_25695	COG1131	(ABC) transporter
I0K14_25700	COG0024	Methionine aminopeptidase
I0K14_25710	COG2234	aminopeptidase activity
I0K14_25730	COG4506	Protein conserved in bacteria
I0K14_25735	COG1619	proteins homologs of microcin C7 resistance protein MccF
I0K14_25760	COG2814	Major facilitator Superfamily
I0K14_25765	COG0789	Transcriptional regulator
I0K14_25770	COG0584	glycerophosphoryl diester phosphodiesterase
I0K14_25775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I0K14_25785	COG1994	Peptidase M50
I0K14_25795	COG1078	dGTPase activity
I0K14_25800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I0K14_25805	COG1120	ATPase activity
I0K14_25810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_25815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I0K14_25835	COG0095	Lipoate-protein ligase
I0K14_25840	COG0280	phosphate acetyltransferase
I0K14_25855	COG3773	Cell wall hydrolase
I0K14_25865	COG2363	Small membrane protein
I0K14_25875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I0K14_25880	COG2233	PERMEase
I0K14_25885	COG0561	phosphatase activity
I0K14_25890	COG2814	Major facilitator Superfamily
I0K14_25900	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I0K14_25905	COG1131	(ABC) transporter
I0K14_25910	COG2755	lipolytic protein G-D-S-L family
I0K14_25915	COG1609	Transcriptional regulator
I0K14_25925	COG0460	homoserine dehydrogenase
I0K14_25935	COG2873	o-acetylhomoserine
I0K14_25940	COG1011	Hydrolase
I0K14_25945	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I0K14_25955	COG2197	response regulator
I0K14_25960	COG4585	Histidine kinase
I0K14_25960	COG2203	Gaf domain
I0K14_25965	COG0351	phosphomethylpyrimidine kinase
I0K14_25970	COG3706	GGDEF domain
I0K14_25975	COG2879	small protein
I0K14_25980	COG1966	Carbon starvation protein
I0K14_25985	COG3279	Response regulator of the LytR AlgR family
I0K14_25990	COG0477	Major facilitator Superfamily
I0K14_26000	COG0438	transferase activity, transferring glycosyl groups
I0K14_26015	COG0840	transmembrane signaling receptor activity
I0K14_26025	COG1607	acyl-coa hydrolase
I0K14_26030	COG1216	Glycosyl transferase, family 2
I0K14_26045	COG1216	Glycosyl transferase, family 2
I0K14_26050	COG0488	(ABC) transporter
I0K14_26055	COG1696	Membrane protein involved in D-alanine export
I0K14_26065	COG1309	transcriptional regulator
I0K14_26070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I0K14_26075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K14_26075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I0K14_26085	COG0628	permease
I0K14_26100	COG3279	Response regulator of the LytR AlgR family
I0K14_26105	COG3275	phosphorelay sensor kinase activity
I0K14_26110	COG2814	Major facilitator Superfamily
I0K14_26115	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I0K14_26120	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
I0K14_26125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I0K14_26170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I0K14_26175	COG1272	protein, Hemolysin III
I0K14_26195	COG1164	Oligoendopeptidase f
I0K14_26215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I0K14_26220	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I0K14_26225	COG4853	Protein conserved in bacteria
I0K14_26230	COG4863	YycH protein
I0K14_26235	COG5002	protein histidine kinase activity
I0K14_26240	COG0745	RESPONSE REGULATOR receiver
I0K14_26270	COG0305	Participates in initiation and elongation during chromosome replication
I0K14_26280	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
I0K14_26285	COG4241	membrane
I0K14_26295	COG0629	single-stranded DNA binding
I0K14_26305	COG0012	GTP binding
I0K14_26310	COG4481	Protein conserved in bacteria
I0K14_26315	COG0668	transmembrane transport
I0K14_26325	COG1475	DNA binding
I0K14_26330	COG1192	Involved in chromosome partitioning
I0K14_26355	COG1847	R3H domain protein
I0K14_26360	COG0706	membrane insertase activity
I0K14_26370	COG0230	Belongs to the bacterial ribosomal protein bL34 family