locus-tag class description FOW48_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOW48_00015 ENOG410848D S4 domain protein YaaA FOW48_00030 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOW48_00065 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FOW48_00110 ENOG4105GTG Isochorismatase FOW48_00115 ENOG4108Z6B deaminase FOW48_00125 ENOG4105C6E dna polymerase iii FOW48_00145 ENOG41067KS pro-sigma K processing FOW48_00180 ENOG4105CXN decarboxylase FOW48_00190 ENOG4105FA2 dna polymerase iii FOW48_00195 ENOG4105MA4 psp1 domain protein FOW48_00205 ENOG41060K3 Methyltransferase FOW48_00215 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FOW48_00220 ENOG4105KRN Transcriptional regulator, abrb family FOW48_00230 ENOG4105F8V Hydrolase, tatD family FOW48_00235 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FOW48_00250 ENOG4105W42 Veg protein FOW48_00265 ENOG4105DFT pur operon repressor FOW48_00270 ENOG4105KME endoribonuclease L-psp FOW48_00285 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FOW48_00300 ENOG4108JA2 transcriptioN-repair coupling factor FOW48_00305 ENOG4108M14 stage v sporulation protein t FOW48_00315 ENOG4108IY2 MazG family FOW48_00320 ENOG41082I2 s4 domain protein FOW48_00325 ENOG4105VYY sporulation protein yabp FOW48_00340 ENOG41060GV RNA binding s1 domain protein FOW48_00365 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOW48_00370 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FOW48_00385 ENOG4105C6T cysteine synthase FOW48_00390 ENOG4105CRQ synthase (Component I) FOW48_00395 ENOG4105DDQ anthranilate synthase FOW48_00400 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FOW48_00405 ENOG4105EEI dihydropteroate synthase FOW48_00410 ENOG4105KRF dihydroneopterin aldolase FOW48_00415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FOW48_00425 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FOW48_00515 ENOG4108Z0C Uvrb UvrC protein FOW48_00530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FOW48_00540 ENOG4105CTP PilT protein domain protein FOW48_00560 ENOG4105D7W serine acetyltransferase FOW48_00575 ENOG4105C2N RNA methyltransferase TrmH family group 3 FOW48_00580 ENOG4105M0M Tetracycline resistance protein FOW48_00585 ENOG4105QIV RNA polymerase FOW48_00600 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FOW48_00625 ENOG4107Y49 methyltransferase FOW48_00640 ENOG4105XPM ribosomal protein FOW48_00750 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FOW48_00775 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOW48_00785 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOW48_00795 ENOG41067V7 50S ribosomal protein L36 FOW48_00825 ENOG4108JJB ABC transporter FOW48_00830 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FOW48_00860 ENOG4105D1F ATP-binding protein FOW48_00875 ENOG4108NMV polysaccharide deacetylase FOW48_00955 ENOG4105C8B TIGR00159 family FOW48_00960 ENOG4107U5W ybbr family FOW48_00980 ENOG4108VQT Alpha beta hydrolase fold protein FOW48_00990 ENOG4105CMG Carbohydrate kinase FOW48_01000 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FOW48_01035 ENOG4108PSK reductase FOW48_01040 ENOG4108UMI ABC transporter, permease FOW48_01050 ENOG4105D01 (LipO)protein FOW48_01055 ENOG4105EE1 crotonyl-CoA reductase FOW48_01065 ENOG4105IQ5 FAD linked oxidase domain protein FOW48_01080 ENOG4105C2C drug resistance transporter, Bcr CflA FOW48_01095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOW48_01100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOW48_01105 ENOG4105C3U ABC transporter FOW48_01110 ENOG4108JQ7 (ABC) transporter FOW48_01130 ENOG4108J59 Extracellular solute-binding protein, family 5 FOW48_01135 ENOG4108J59 Extracellular solute-binding protein, family 5 FOW48_01150 ENOG4107XDY Nicotinamide Mononucleotide Transporter FOW48_01160 ENOG4105E0C molybdate abc transporter FOW48_01165 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FOW48_01170 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FOW48_01200 ENOG4105F6E Acyl-transferase FOW48_01220 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOW48_01230 ENOG4108RE7 deoxyribonuclease FOW48_01235 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FOW48_01255 ENOG4105C5H ABC transporter FOW48_01265 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FOW48_01270 ENOG4105DEF Extracellular solute-binding protein, family 5 FOW48_01280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOW48_01285 ENOG4105C3U ABC transporter FOW48_01295 ENOG410667J hydrolase FOW48_01330 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase FOW48_01335 ENOG4105ERH Fumarylacetoacetate hydrolase FOW48_01345 ENOG4105CUB amino acid FOW48_01355 ENOG4105CPF Cell wall formation (By similarity) FOW48_01360 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOW48_01385 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FOW48_01390 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOW48_01400 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FOW48_01500 ENOG4105K8N protein family UPF0079, ATPase FOW48_01505 ENOG41072GX Peptidase M22 Glycoprotease FOW48_01510 ENOG410801F ribosomal-protein-alanine acetyltransferase FOW48_01520 ENOG4105C5H ABC transporter FOW48_01535 ENOG4108TYN CAAX amino terminal protease family protein FOW48_01555 ENOG4105C7N Xanthine uracil vitamin C permease FOW48_01565 ENOG4105BZU Histidine kinase FOW48_01595 ENOG4107ZXU DSBA oxidoreductase FOW48_01625 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOW48_01645 ENOG4108SHN Glycosyl transferase, family 2 FOW48_01665 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOW48_01695 ENOG4105SX7 Transporter FOW48_01725 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FOW48_01730 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FOW48_01735 ENOG4105C83 adenylosuccinate lyase FOW48_01745 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FOW48_01770 ENOG4108V3E phosphoribosylglycinamide formyltransferase FOW48_01785 ENOG4105C12 Phosphoribosylglycinamide synthetase FOW48_01815 ENOG4105C4R Atp-dependent dna helicase FOW48_01840 ENOG4108W2Y isochorismatase FOW48_01850 ENOG4108UMI ABC transporter, permease FOW48_01855 ENOG4105D01 (LipO)protein FOW48_01875 ENOG410834F Transcriptional regulator FOW48_01880 ENOG4107I77 yiaA/B two helix domain FOW48_01900 ENOG4105CBD Diacylglycerol kinase FOW48_01905 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOW48_01910 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FOW48_01915 ENOG4108JPW Aminotransferase FOW48_01925 ENOG4105C26 Dehydrogenase FOW48_01930 ENOG4105KPY Small multidrug resistance protein FOW48_01945 ENOG4105D9N nucleoside FOW48_01950 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FOW48_01960 ENOG4105BZU Histidine kinase FOW48_01965 ENOG4105C7K acetolactate synthase FOW48_01975 ENOG4108W15 Protein of unknown function (DUF1456) FOW48_02000 ENOG4105DDC Oxidoreductase domain protein FOW48_02005 ENOG4105CQB FAD linked oxidase domain protein FOW48_02015 ENOG4105CWC Acetylornithine deacetylase FOW48_02035 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FOW48_02040 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOW48_02050 ENOG4107Y80 Major Facilitator superfamily FOW48_02060 ENOG4108W15 Protein of unknown function (DUF1456) FOW48_02075 ENOG4105DTQ mandelate racemase muconate lactonizing FOW48_02085 ENOG4105DFD Na H antiporter FOW48_02105 ENOG4105D3R alkyl hydroperoxide reductase FOW48_02110 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FOW48_02120 ENOG4107W7X Aldolase FOW48_02135 ENOG4105EHG Permease protein FOW48_02140 ENOG4105DQ5 transport system permease protein FOW48_02145 ENOG4108V5C ABC transporter FOW48_02170 ENOG4106UIA FOW48_02175 ENOG4106UIA FOW48_02205 ENOG410756H nucleotidyltransferase FOW48_02210 ENOG4105D2S major facilitator superfamily FOW48_02235 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOW48_02240 ENOG4105E5Q amino acid AbC transporter FOW48_02245 ENOG4105EAB amino acid AbC transporter FOW48_02255 ENOG4105C8Q Methyl-accepting chemotaxis FOW48_02265 ENOG4105CI1 PTS System FOW48_02295 ENOG4107RBB ABC transporter, permease FOW48_02300 ENOG4105C19 ABC transporter FOW48_02325 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FOW48_02360 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FOW48_02375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOW48_02395 ENOG4105C5H ABC transporter FOW48_02425 ENOG41062JF Transcriptional regulator FOW48_02445 ENOG4105DEU major facilitator superfamily FOW48_02475 ENOG4108N0M stress protein FOW48_02480 ENOG4106FN3 tellurium resistance protein FOW48_02485 ENOG4106FN3 tellurium resistance protein FOW48_02490 ENOG4107TS3 membrane protein, TerC FOW48_02495 ENOG4108TTB tellurium resistance protein FOW48_02515 ENOG4105KJF protein tyrosine phosphatase FOW48_02525 ENOG4107U9T Pfam:Ribonuclease_BN FOW48_02530 ENOG4105C59 p-type ATPase FOW48_02535 ENOG4108IPJ Membrane FOW48_02560 ENOG4107ZTW SNARE associated Golgi FOW48_02575 ENOG410606W general stress protein FOW48_02580 ENOG4105UPD Calcium Proton FOW48_02640 ENOG4108IQI permease FOW48_02670 ENOG4105CSV Glutaminase FOW48_02685 ENOG4108A04 Beta-lactamase FOW48_02700 ENOG4105CKK Glycosyl transferase, family 2 FOW48_02705 ENOG4107QQG Dehydrogenase FOW48_02710 ENOG4105C3I Nad-dependent epimerase dehydratase FOW48_02730 ENOG4105F1A Pyruvate formate-lyase FOW48_02750 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FOW48_02755 ENOG4105ECP epimerase FOW48_02785 ENOG41067AE Membrane-bound metal-dependent hydrolase FOW48_02790 ENOG4105CEN a g-specific adenine glycosylase FOW48_02795 ENOG4106BXE FOW48_02815 ENOG4105BZ1 (ABC) transporter FOW48_02820 ENOG4107NBY Membrane FOW48_02825 ENOG4105CBC glutamate synthase FOW48_02835 ENOG4108IUW ABC transporter FOW48_02855 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOW48_02860 ENOG4105G5W regulator Fur family FOW48_02970 ENOG4108JQC penicillin-binding protein 1A FOW48_02975 ENOG4108R9S DSBA oxidoreductase FOW48_02990 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FOW48_03000 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FOW48_03010 ENOG4105CYN Serine protein kinase FOW48_03030 ENOG4105C94 Transporter FOW48_03045 ENOG4105DZ6 Band 7 protein FOW48_03055 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FOW48_03065 ENOG4105D4T Citrate transporter FOW48_03090 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOW48_03095 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOW48_03100 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FOW48_03105 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FOW48_03110 ENOG4105BZ7 extracellular solute-binding protein family 1 FOW48_03115 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FOW48_03120 ENOG4108STX response regulator FOW48_03125 ENOG4105US7 Histidine kinase FOW48_03145 ENOG4108UZ3 Transporter FOW48_03150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOW48_03160 ENOG4105BZU Histidine kinase FOW48_03165 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_03170 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOW48_03175 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOW48_03180 ENOG4108JB9 formate dehydrogenase FOW48_03200 ENOG4105CUB amino acid FOW48_03210 ENOG4105C59 p-type ATPase FOW48_03215 ENOG4105DAP Nicotinate phosphoribosyltransferase FOW48_03250 ENOG41073R8 VanW family FOW48_03255 ENOG4108KGH TRANSCRIPTIONal FOW48_03260 ENOG4105D9N nucleoside FOW48_03265 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FOW48_03270 ENOG4105C37 (CBS) domain FOW48_03275 ENOG4108IJ0 Aspartate ammonia-lyase FOW48_03285 ENOG4105DAA L-lactate FOW48_03300 ENOG4105DUX Transporter FOW48_03305 ENOG4108MES Periplasmic binding protein FOW48_03310 ENOG4105DQ5 transport system permease protein FOW48_03315 ENOG4108IHU transport system permease protein FOW48_03320 ENOG4105E0A ABC, transporter FOW48_03325 ENOG4105DMQ Methyltransferase FOW48_03340 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FOW48_03350 ENOG4107T89 von Willebrand factor, type A FOW48_03355 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FOW48_03375 ENOG4105BZU Histidine kinase FOW48_03380 ENOG4105D5Q Arginine ornithine antiporter FOW48_03385 ENOG4107414 GntR family transcriptional regulator FOW48_03390 ENOG4105C5Y PTS System FOW48_03395 ENOG4105CG3 alpha amylase, catalytic region FOW48_03410 ENOG4105E1K spore germination protein FOW48_03415 ENOG4105CRN Aminoglycoside phosphotransferase FOW48_03420 ENOG4105BZG amino acid carrier protein FOW48_03425 ENOG4105CDA abc transporter atp-binding protein FOW48_03430 ENOG4105CT1 (ABC) transporter FOW48_03435 ENOG4105EAD ABC transporter FOW48_03440 ENOG4105DRP amino acid AbC transporter FOW48_03445 ENOG4108IQI permease FOW48_03460 ENOG4105GFR rna polymerase sigma factor FOW48_03470 ENOG4105D29 Helix-turn-helix type 11 domain protein FOW48_03475 ENOG4105NAE bifunctional deaminase-reductase domain protein FOW48_03480 ENOG4105BZU Histidine kinase FOW48_03495 ENOG4105CHH sulfate transporter FOW48_03500 ENOG41068KF Universal stress protein FOW48_03510 ENOG4105DEF Extracellular solute-binding protein, family 5 FOW48_03520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOW48_03525 ENOG4108JQ7 (ABC) transporter FOW48_03535 ENOG4105CXY transporter FOW48_03540 ENOG41067TZ transcriptional regulator, MarR family FOW48_03545 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_03550 ENOG4105ETE Transcriptional regulator (LacI family FOW48_03555 ENOG4108RVA ribokinase FOW48_03565 ENOG4105C2J ABC transporter FOW48_03570 ENOG4105CNN ABC, transporter FOW48_03575 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FOW48_03580 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOW48_03640 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOW48_03645 ENOG41069ER domain protein FOW48_03650 ENOG4105VZ8 Transcriptional regulator FOW48_03655 ENOG4107D63 FOW48_03670 ENOG4105DUX Transporter FOW48_03690 ENOG4105C85 amino acid FOW48_03695 ENOG4105C7N Xanthine uracil vitamin C permease FOW48_03710 ENOG4105MA6 gCN5-related N-acetyltransferase FOW48_03735 ENOG4105BZ9 Cytochrome C oxidase, subunit I FOW48_03740 ENOG4105E2S oxidase) subunit II FOW48_03760 ENOG4106CAD Protein of unknown function (DUF3311) FOW48_03765 ENOG4105E1V na solute symporter FOW48_03785 ENOG4105CE1 Ferrous iron transport protein b FOW48_03790 ENOG4105CE1 Ferrous iron transport protein b FOW48_03795 ENOG4105CE1 Ferrous iron transport protein b FOW48_03800 ENOG4105CVA phosphate FOW48_03805 ENOG4105C8U phosphate abc transporter FOW48_03810 ENOG4105E2Z phosphate ABC transporter (Permease FOW48_03935 ENOG41080XQ Signal transduction protein with cbs domains FOW48_03955 ENOG4105ETU transcriptional activator (TenA FOW48_03965 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOW48_03975 ENOG4108VEU Thiamine monophosphate synthase FOW48_03980 ENOG41080HI glycine oxidase FOW48_03995 ENOG4105D06 uba thif-type nad fad binding protein FOW48_04000 ENOG4105DWF phosphomethylpyrimidine kinase FOW48_04050 ENOG4108INS Transcriptional regulator FOW48_04075 ENOG4105C19 ABC transporter FOW48_04085 ENOG4105F5R ABC transporter FOW48_04090 ENOG4105C2J ABC transporter FOW48_04095 ENOG4108QGH periplasmic FOW48_04100 ENOG4105C7N Xanthine uracil vitamin C permease FOW48_04110 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOW48_04165 ENOG4108B31 Spore germination protein FOW48_04185 ENOG4107Y03 Nitroreductase FOW48_04190 ENOG4105ED1 spovr family FOW48_04220 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FOW48_04225 ENOG4105XTG Pfam:DUF156 FOW48_04230 ENOG4105VFE sira family FOW48_04235 ENOG4107TPS domain protein FOW48_04240 ENOG4105VFE sira family FOW48_04245 ENOG4105VFE sira family FOW48_04255 ENOG4105VFE sira family FOW48_04265 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FOW48_04270 ENOG41087NI Sulfite exporter TauE/SafE FOW48_04310 ENOG4105EMD TRANSCRIPTIONal FOW48_04315 ENOG4105VCP PTS System FOW48_04320 ENOG4105VZJ PTS System FOW48_04355 ENOG4105C19 ABC transporter FOW48_04385 ENOG4105WEF catalase FOW48_04420 ENOG4107T5V SNARE associated Golgi FOW48_04450 ENOG4105CUB amino acid FOW48_04455 ENOG4107RWR Sodium hydrogen exchanger FOW48_04465 ENOG4106KNT transcriptional regulator FOW48_04505 ENOG4108YXU transcriptional regulator AsnC family FOW48_04515 ENOG4105KPY Small multidrug resistance protein FOW48_04520 ENOG4105KPY Small multidrug resistance protein FOW48_04545 ENOG41061H0 Monooxygenase FOW48_04550 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_04570 ENOG4106A3M Cytochrome p-450 FOW48_04600 ENOG4105EWC Purine nucleoside phosphorylase FOW48_04610 ENOG4105K8R UPF0145 protein FOW48_04625 ENOG4105EKQ RNA-directed DNA polymerase FOW48_04645 ENOG4105NF4 modulator of drug activity FOW48_04650 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOW48_04655 ENOG4105E5W Transporter FOW48_04665 ENOG4107RKG DJ-1/PfpI family FOW48_04675 ENOG4105D5Q Arginine ornithine antiporter FOW48_04680 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FOW48_04685 ENOG4105C26 Dehydrogenase FOW48_04700 ENOG4105BZ1 (ABC) transporter FOW48_04705 ENOG4105BZ1 (ABC) transporter FOW48_04720 ENOG4105DRP amino acid AbC transporter FOW48_04725 ENOG4105CDA abc transporter atp-binding protein FOW48_04740 ENOG410839P FOW48_04775 ENOG4107FQX Alpha-acetolactate decarboxylase FOW48_04790 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOW48_04795 ENOG4105D4P Coproporphyrinogen iii oxidase FOW48_04810 ENOG4105EKQ RNA-directed DNA polymerase FOW48_04825 ENOG4105CHH sulfate transporter FOW48_04860 ENOG4106AKK s-layer domain-containing protein FOW48_04870 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOW48_04875 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOW48_04890 ENOG4105CGU Enoyl-CoA hydratase FOW48_04925 ENOG4105DER m42 family FOW48_04980 ENOG4105CSH Transporter FOW48_04990 ENOG4108MRH transcriptional regulatory protein FOW48_05085 ENOG4105CDU Replicative dna helicase FOW48_05105 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_05180 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOW48_05195 ENOG4105CMT Dihydroxyacetone kinase FOW48_05210 ENOG4105CMT Dihydroxyacetone kinase FOW48_05235 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FOW48_05345 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOW48_05355 ENOG4108MJI response regulator FOW48_05360 ENOG4105BZU Histidine kinase FOW48_05365 ENOG4105BZU Histidine kinase FOW48_05385 ENOG4105K8R UPF0145 protein FOW48_05425 ENOG4107VRP DNA repair exonuclease FOW48_05430 ENOG4106D4I domain protein FOW48_05440 ENOG4108IND Tetr family transcriptional regulator FOW48_05445 ENOG4105EQ0 Major Facilitator superfamily FOW48_05460 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOW48_05470 ENOG4108MUZ hydrolase FOW48_05500 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FOW48_05515 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FOW48_05525 ENOG4105EMN RNA polymerase sigma factor FOW48_05535 ENOG4105CNI cell division protein FtsW FOW48_05545 ENOG4105EEM helicase FOW48_05575 ENOG4105K59 histidine triad (HIT) protein FOW48_05605 ENOG410905X membrane-flanked domain protein FOW48_05610 ENOG4105CKV Membrane FOW48_05640 ENOG410905X membrane-flanked domain protein FOW48_05645 ENOG4105CKV Membrane FOW48_05650 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FOW48_05665 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FOW48_05670 ENOG4105C1Q protoporphyrinogen oxidase FOW48_05700 ENOG4105ECB domain protein FOW48_05730 ENOG4105D29 Helix-turn-helix type 11 domain protein FOW48_05745 ENOG4106AXD FOW48_05750 ENOG4108RQ5 Beta-lactamase domain-containing protein FOW48_05755 ENOG4105DF9 Lipoate-protein, ligase FOW48_05765 ENOG4105CEY Amp-dependent synthetase and ligase FOW48_05780 ENOG4105CNA YD repeat protein FOW48_05840 ENOG4105ST3 Transcriptional regulator FOW48_05845 ENOG4105ENX hydrolase FOW48_05850 ENOG4107RN3 metallophosphoesterase FOW48_05860 ENOG4107TVP HD domain protein FOW48_05870 ENOG4108AEY RNA polymerase sigma factor FOW48_05880 ENOG41086D8 Transcriptional regulator FOW48_05895 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOW48_05920 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FOW48_05940 ENOG4105ZU5 s-layer protein FOW48_05945 ENOG4107QP3 malate synthase g FOW48_05965 ENOG4105VEQ Cold shock protein FOW48_05980 ENOG4105XVF Competence transcription factor FOW48_06050 ENOG4105ERH Fumarylacetoacetate hydrolase FOW48_06075 ENOG4105CAQ asparagine synthetase FOW48_06085 ENOG4105CH6 catalase FOW48_06090 ENOG4105BZU Histidine kinase FOW48_06115 ENOG4105QNR S1 RNA binding domain protein FOW48_06120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOW48_06130 ENOG4107AYK membrAne FOW48_06135 ENOG41073B9 FOW48_06145 ENOG4108KP7 hydrolase FOW48_06180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FOW48_06185 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FOW48_06200 ENOG4105C31 Tryptophanyl-tRNA synthetase FOW48_06220 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FOW48_06225 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FOW48_06235 ENOG4108JQ7 (ABC) transporter FOW48_06240 ENOG4105UQX Mate efflux family protein FOW48_06260 ENOG4108ZCF integral membrane protein FOW48_06270 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOW48_06280 ENOG4105DPN Oligoendopeptidase f FOW48_06290 ENOG4108Z18 K06886 hemoglobin FOW48_06295 ENOG4105MIX Adenylate cyclase FOW48_06300 ENOG4106EFP UPF0738 protein FOW48_06315 ENOG4105EMS pseudouridine synthase FOW48_06335 ENOG4105K64 Glycosyl transferase, family 2 FOW48_06355 ENOG4107TVC Glycosyl transferase, family 2 FOW48_06375 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FOW48_06380 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FOW48_06390 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FOW48_06465 ENOG4105CK7 Sodium proline symporter FOW48_06475 ENOG4105CRQ synthase (Component I) FOW48_06480 ENOG4105DDQ anthranilate synthase FOW48_06605 ENOG4105VZ8 Transcriptional regulator FOW48_06660 ENOG4105DZ1 carboxypeptidase FOW48_06665 ENOG4105VFR signal peptidase FOW48_06700 ENOG4105C26 Dehydrogenase FOW48_06710 ENOG4105F38 ABC transporter, permease FOW48_06715 ENOG4105D38 putrescine abc transporter FOW48_06720 ENOG4107RUE extracellular solute-binding protein family 1 FOW48_06730 ENOG4105EYF MMPL domain protein FOW48_06740 ENOG4108YBP pseudouridine synthase FOW48_06750 ENOG4105K4I Scp-like extracellular FOW48_06755 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FOW48_06760 ENOG4105CQB FAD linked oxidase domain protein FOW48_06775 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_06780 ENOG4105BZU Histidine kinase FOW48_06785 ENOG4105JXH GntR family transcriptional regulator FOW48_06805 ENOG4106A3R peptidase FOW48_06815 ENOG4108QTI )-transporter FOW48_06820 ENOG4107TS3 membrane protein, TerC FOW48_06830 ENOG410681C small acid-soluble spore protein FOW48_06835 ENOG4108Z7G MaoC domain protein dehydratase FOW48_06855 ENOG4105CHR reductase FOW48_06885 ENOG4105C4Y ABC transporter FOW48_06890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOW48_06895 ENOG4107RCV ABC transporter, permease FOW48_06915 ENOG4105E98 transcriptional regulator DeoR family FOW48_06925 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FOW48_06935 ENOG4105PXI polysaccharide deacetylase FOW48_06945 ENOG4105BZU Histidine kinase FOW48_06950 ENOG41090MY MarR family Transcriptional regulator FOW48_06960 ENOG4106DF1 FOW48_06970 ENOG4105BZU Histidine kinase FOW48_06980 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FOW48_06985 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FOW48_07030 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FOW48_07055 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FOW48_07060 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOW48_07065 ENOG4105CZV ABC transporter FOW48_07075 ENOG4105CJ1 ABC, transporter FOW48_07115 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOW48_07120 ENOG4105EA8 2-Nitropropane dioxygenase FOW48_07125 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOW48_07135 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FOW48_07155 ENOG4105NQC Flavodoxin FOW48_07180 ENOG4107QMU Mate efflux family protein FOW48_07215 ENOG4105CZN Potassium uptake protein FOW48_07220 ENOG41063Y9 FOW48_07225 ENOG4105KBJ sporulation protein ytfj FOW48_07245 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOW48_07250 ENOG4105C7K acetolactate synthase FOW48_07255 ENOG4108ZP8 Acetolactate synthase small subunit FOW48_07330 ENOG4107RVV histidinol phosphate phosphatase, hisj family FOW48_07345 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FOW48_07350 ENOG4105E0M Sulfatase FOW48_07360 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FOW48_07380 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FOW48_07385 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FOW48_07395 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOW48_07400 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOW48_07405 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOW48_07410 ENOG4105C8J )-transporter FOW48_07430 ENOG4105DFD Na H antiporter FOW48_07450 ENOG4105ENE Histidine kinase FOW48_07455 ENOG4105WH1 Two component transcriptional regulator luxr family FOW48_07475 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOW48_07520 ENOG4105CJ3 phosphate transporter FOW48_07525 ENOG4107GRR phosphate transport regulator FOW48_07530 ENOG4105BZ4 penicillin-binding protein FOW48_07545 ENOG4105BZU Histidine kinase FOW48_07550 ENOG4105I3N Conserved Protein FOW48_07595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOW48_07600 ENOG4105DZ1 carboxypeptidase FOW48_07605 ENOG4108JIC nucleoside recognition domain protein FOW48_07615 ENOG4105FE9 pseudouridine synthase FOW48_07625 ENOG4107TWT Cytochrome c biogenesis protein FOW48_07630 ENOG4105CRE cytochrome C FOW48_07635 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_07645 ENOG4108WBT adenosyltransferase FOW48_07650 ENOG41063SB peptidase FOW48_07660 ENOG4108SAX Membrane FOW48_07675 ENOG4105C9U ATP-dependent DNA helicase RecQ FOW48_07680 ENOG4105I7S Abortive infection protein FOW48_07690 ENOG4107RGJ metallophosphoesterase FOW48_07695 ENOG4107X2D transcriptional regulator, merr family FOW48_07700 ENOG4108S6Z Negative regulator of genetic competence FOW48_07725 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FOW48_07730 ENOG4105HDK L-asparaginase FOW48_07760 ENOG4105S2F FOW48_07765 ENOG41065D1 FOW48_07795 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FOW48_07810 ENOG4105XXQ heptaprenyl diphosphate synthase component I FOW48_07820 ENOG4105EAH synthase FOW48_07840 ENOG4105CIH Imidazole acetol-phosphate transaminase FOW48_07850 ENOG41068YB TPR repeat-containing protein FOW48_07865 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FOW48_07870 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FOW48_07910 ENOG4108JYZ YitT family FOW48_07915 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FOW48_07930 ENOG4105FJR Lmbe family FOW48_07935 ENOG4105CPK Glycosyl transferase (Group 1 FOW48_07970 ENOG4105DVT helicase FOW48_07975 ENOG4105YAC FOW48_07995 ENOG4105CSM endonuclease III FOW48_08005 ENOG4105BZ4 penicillin-binding protein FOW48_08060 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FOW48_08070 ENOG4105DVT helicase FOW48_08085 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FOW48_08095 ENOG4105C2W permease FOW48_08100 ENOG4105DHF Membrane FOW48_08105 ENOG410890F Dynamin family FOW48_08115 ENOG4108W0I acetyltransferase FOW48_08125 ENOG4105KHC sulfurtransferase FOW48_08150 ENOG4106032 Glutathionylspermidine synthase FOW48_08210 ENOG41081VK Ribonuclease FOW48_08275 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOW48_08285 ENOG4107RWR Sodium hydrogen exchanger FOW48_08290 ENOG4105CN5 Metallo-Beta-Lactamase FOW48_08295 ENOG4108Z5V transcriptional regulator, merr family FOW48_08310 ENOG4105H67 Protein of unknown function (DUF421) FOW48_08315 ENOG41080C8 DUF218 domain FOW48_08350 ENOG4107Y80 Major Facilitator superfamily FOW48_08380 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOW48_08390 ENOG4107R0U MotA TolQ exbB proton channel FOW48_08395 ENOG4105ER2 Ompa motb domain protein FOW48_08400 ENOG4107YTP response regulator receiver protein FOW48_08405 ENOG4105CBS Chea signal transduction histidine kinase FOW48_08410 ENOG4105DD5 Flagellar motor switch protein FOW48_08425 ENOG4105BZU Histidine kinase FOW48_08445 ENOG4105E1Q flagellar hook-associated protein FOW48_08450 ENOG4105DTJ flagellar hook-associated protein FOW48_08455 ENOG4107TPX flagellar hook-associated FOW48_08470 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FOW48_08475 ENOG4108ZC9 flagellar basal-body rod protein flgc FOW48_08480 ENOG41075Z6 flagellar hook-basal body complex protein fliE FOW48_08485 ENOG4107U2N Flagellar M-ring protein FOW48_08490 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOW48_08520 ENOG4105BZE flagellar hook protein, FlgE FOW48_08535 ENOG4107R88 Chemotaxis protein (CheV) FOW48_08550 ENOG4105I03 Flagellin FOW48_08555 ENOG4105I03 Flagellin FOW48_08560 ENOG4105E4C Lytic transglycosylase catalytic FOW48_08570 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FOW48_08575 ENOG4105DD5 Flagellar motor switch protein FOW48_08585 ENOG4105CN7 Flagellar biosynthetic protein FliP FOW48_08590 ENOG4105VS8 Flagellar biosynthetic protein fliq FOW48_08605 ENOG4105D7B Flagellar biosynthesis protein flha FOW48_08610 ENOG4105FZW flagellar biosynthesis regulator FlhF FOW48_08615 ENOG4105KTQ flagellar basal-body rod protein FOW48_08620 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOW48_08655 ENOG4105KAC Antibiotic biosynthesis monooxygenase FOW48_08675 ENOG4108U4N (sortase) family FOW48_08700 ENOG4105DUM transcriptional regulator, lysR family FOW48_08705 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FOW48_08720 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FOW48_08735 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FOW48_08760 ENOG4105CVJ phosphoglycerate mutase FOW48_08780 ENOG4105K56 Transcriptional regulator FOW48_08790 ENOG4105CAQ asparagine synthetase FOW48_08795 ENOG4105EKQ RNA-directed DNA polymerase FOW48_08800 ENOG4105CAQ asparagine synthetase FOW48_08820 ENOG4105PGM cation diffusion facilitator family transporter FOW48_08835 ENOG4108UZ3 Transporter FOW48_08845 ENOG4105DFD Na H antiporter FOW48_08850 ENOG4105C9Q fumarate hydratase class II FOW48_08870 ENOG4107QJQ Mate efflux family protein FOW48_08875 ENOG4105EC3 peptidase S51, dipeptidase E FOW48_08915 ENOG4106BRA Membrane FOW48_08955 ENOG4105CJ1 ABC, transporter FOW48_08975 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FOW48_08985 ENOG4108IJ0 Aspartate ammonia-lyase FOW48_08990 ENOG4105C6K Malic enzyme FOW48_09110 ENOG4105CSR polyphosphate kinase 2 FOW48_09115 ENOG4105U3E Transcriptional regulator FOW48_09125 ENOG4105DXI Major Facilitator superfamily FOW48_09140 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOW48_09150 ENOG4105EU0 Major facilitator Superfamily FOW48_09155 ENOG4105C6T cysteine synthase FOW48_09175 ENOG4105C8J )-transporter FOW48_09185 ENOG4105X5K response regulator receiver protein FOW48_09190 ENOG4105H67 Protein of unknown function (DUF421) FOW48_09205 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FOW48_09210 ENOG4105CM2 brancheD-chain amino acid aminotransferase FOW48_09215 ENOG4105C7K acetolactate synthase FOW48_09220 ENOG4108ZP8 Acetolactate synthase small subunit FOW48_09225 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FOW48_09235 ENOG4105C7B Threonine dehydratase FOW48_09260 ENOG4105C6X Major Facilitator FOW48_09265 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FOW48_09275 ENOG4105DY9 regulatoR FOW48_09280 ENOG4105CYC Transferase FOW48_09310 ENOG41068WN FOW48_09315 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOW48_09330 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FOW48_09345 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FOW48_09380 ENOG4107RHR regulatoR FOW48_09415 ENOG4107RAQ aminopeptidase FOW48_09465 ENOG4108T5E Copper resistance protein FOW48_09470 ENOG4105KTB nuclear export factor GLE1 FOW48_09475 ENOG4107RT3 EamA-like transporter family FOW48_09480 ENOG4105GZI Transcriptional regulator FOW48_09485 ENOG4108Z40 Transcriptional regulator FOW48_09490 ENOG4107ZXU DSBA oxidoreductase FOW48_09495 ENOG4108TVJ Nitroreductase FOW48_09500 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOW48_09505 ENOG4106F5Q Membrane FOW48_09510 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FOW48_09520 ENOG4105CKI cobalamin synthesis protein FOW48_09530 ENOG4105C0Z ABC transporter FOW48_09535 ENOG4108IV0 ABC, transporter FOW48_09540 ENOG4105C32 Amino acid ABC transporter (Permease) FOW48_09550 ENOG4105SKE transcriptional Regulator LysR family FOW48_09560 ENOG4105MDS 4-oxalocrotonate tautomerase FOW48_09580 ENOG4105C4M (Ubiquinol oxidase) subunit I FOW48_09585 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOW48_09590 ENOG4108JJ9 ABC, transporter FOW48_09595 ENOG4108JJ8 (ABC) transporter FOW48_09615 ENOG4108UT6 Transferase hexapeptide repeat containing protein FOW48_09640 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOW48_09675 ENOG4105EFI regulatoR FOW48_09680 ENOG4105BZU Histidine kinase FOW48_09700 ENOG41075D4 Aminoglycoside 6-adenylyltransferase FOW48_09705 ENOG4108ZJ4 polysaccharide deacetylase FOW48_09725 ENOG4105D6E homoserine dehydrogenase FOW48_09750 ENOG4108KGH TRANSCRIPTIONal FOW48_09760 ENOG4107VMI polysaccharide deacetylase FOW48_09770 ENOG4105KT7 mgtC SapB transporter FOW48_09775 ENOG4105VRR gCN5-related N-acetyltransferase FOW48_09780 ENOG4105YWU small acid-soluble spore protein FOW48_09790 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FOW48_09845 ENOG4105KRN Transcriptional regulator, abrb family FOW48_09865 ENOG4108KB1 transcriptional regulator, arac family FOW48_09880 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FOW48_09885 ENOG4105CT8 Phosphorylase FOW48_09890 ENOG4105DKQ ROK family FOW48_09895 ENOG4105E70 isomerase FOW48_09900 ENOG4105CE4 GlcNAc 6-P deacetylase FOW48_09905 ENOG4105DE4 1-phosphofructokinase FOW48_09925 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FOW48_09930 ENOG4105YVS arsR family transcriptional regulator FOW48_09935 ENOG4105CPC Aldo Keto reductase FOW48_09940 ENOG4107XZQ multidrug resistance protein FOW48_09965 ENOG4105C8Q Methyl-accepting chemotaxis FOW48_09980 ENOG4108K88 Membrane FOW48_09985 ENOG4108WPJ Ferritin-like domain FOW48_10000 ENOG4105DEN Luciferase family FOW48_10020 ENOG4107QM2 Aldo Keto reductase FOW48_10025 ENOG4105CKI cobalamin synthesis protein FOW48_10035 ENOG4105DSE periplasmic solute binding protein FOW48_10040 ENOG4105K4T epimerase FOW48_10050 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOW48_10075 ENOG4105CVJ phosphoglycerate mutase FOW48_10095 ENOG4107T5V SNARE associated Golgi FOW48_10110 ENOG4108PJD permease FOW48_10120 ENOG4108S4H thioesterase Superfamily protein FOW48_10130 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FOW48_10150 ENOG4105SXS Protein of unknown function (DUF456) FOW48_10155 ENOG4105C37 (CBS) domain FOW48_10175 ENOG4108Z7R Chaperone CsaA FOW48_10195 ENOG4108ZRV stage ii sporulation protein p FOW48_10205 ENOG4108VXD carboxy-peptidase FOW48_10215 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FOW48_10240 ENOG4108X4Q Hydrolase FOW48_10250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FOW48_10255 ENOG4107RBS Methyltransferase FOW48_10270 ENOG41087PP glycosyltransferase MGT family FOW48_10275 ENOG4108JYZ YitT family FOW48_10280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FOW48_10310 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FOW48_10335 ENOG4105KBJ sporulation protein ytfj FOW48_10360 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FOW48_10380 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FOW48_10395 ENOG41067QW Transcriptional regulator FOW48_10425 ENOG4105KRN Transcriptional regulator, abrb family FOW48_10500 ENOG410682Q Phage transcriptional regulator, ArpU FOW48_10550 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOW48_10705 ENOG4105CNW domain protein FOW48_10715 ENOG4108V06 Glutathione peroxidase FOW48_10740 ENOG4108IUE nitrate reductase beta subunit FOW48_10745 ENOG4105R3A Nitrate reductase FOW48_10755 ENOG4107V6Q Cyclic nucleotide-binding domain FOW48_10760 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOW48_10765 ENOG4105D06 uba thif-type nad fad binding protein FOW48_10770 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOW48_10775 ENOG4108ZAF Molybdopterin FOW48_10805 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FOW48_10810 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FOW48_10815 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FOW48_10820 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FOW48_10825 ENOG4108IFG nitrite reductase, (NAD(P)H) FOW48_10830 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FOW48_10865 ENOG4105MCT stage V sporulation protein S FOW48_10905 ENOG4108UUM single-stranded DNA-binding protein FOW48_10935 ENOG4107YX5 Pfam:DUF548 FOW48_10985 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FOW48_10990 ENOG4105C5S asparaginyl-tRNA synthetase FOW48_11015 ENOG4107XGZ Hydrolase FOW48_11020 ENOG4105CY2 Citrate transporter FOW48_11025 ENOG4105C0A alcohol dehydrogenase FOW48_11040 ENOG4105KD7 acetyltransferase FOW48_11045 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FOW48_11070 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FOW48_11085 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FOW48_11110 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FOW48_11115 ENOG4105E9Q Acyl-transferase FOW48_11120 ENOG4108UT2 hemolysin iii FOW48_11130 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FOW48_11140 ENOG4108RCR degv family FOW48_11145 ENOG4105E8R UPF0173 metal-dependent hydrolase FOW48_11150 ENOG4108KF3 Electron transport protein SCO1 SenC FOW48_11155 ENOG4107Y70 Heat shock protein FOW48_11160 ENOG4105CAQ asparagine synthetase FOW48_11180 ENOG4108MES Periplasmic binding protein FOW48_11215 ENOG4105D8X mechanosensitive ion channel FOW48_11220 ENOG4105BZU Histidine kinase FOW48_11225 ENOG4105WH1 Two component transcriptional regulator luxr family FOW48_11235 ENOG4106KNT transcriptional regulator FOW48_11335 ENOG4105C37 (CBS) domain FOW48_11360 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOW48_11375 ENOG4107S4Y M20 DapE family protein YgeY FOW48_11380 ENOG4108TSC N-acetyltransferase FOW48_11385 ENOG4108JUB Transcriptional regulator FOW48_11390 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FOW48_11425 ENOG4108N23 SpoOM-related protein FOW48_11430 ENOG410841Q phosphoesterase PA-phosphatase related protein FOW48_11440 ENOG4105SZ6 Thioredoxin FOW48_11450 ENOG4108TFU terminase (Small subunit) FOW48_11485 ENOG4108AEY RNA polymerase sigma factor FOW48_11520 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FOW48_11575 ENOG4105CZM Major Facilitator FOW48_11580 ENOG4105W8X HesB YadR YfhF-family protein FOW48_11590 ENOG4105DXD 2-methylcitrate dehydratase FOW48_11595 ENOG4105CR4 methylisocitrate lyase FOW48_11600 ENOG4105C1G acyl-Coa dehydrogenase FOW48_11605 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOW48_11615 ENOG4105N14 lysine exporter protein LysE YggA FOW48_11620 ENOG4105E39 Enoyl-CoA hydratase FOW48_11660 ENOG4105FCD Major Facilitator FOW48_11670 ENOG4105E4F Isochorismate synthase FOW48_11675 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FOW48_11680 ENOG4105WQI isochorismatase FOW48_11685 ENOG4105CEY Amp-dependent synthetase and ligase FOW48_11695 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_11710 ENOG4105K70 DNA-binding protein FOW48_11760 ENOG4105FE9 pseudouridine synthase FOW48_11770 ENOG4105C19 ABC transporter FOW48_11805 ENOG4108D32 Methyltransferase FOW48_11830 ENOG41081I9 integral membrane protein FOW48_11875 ENOG4105WCN acetyltransferase FOW48_11900 ENOG4105C1Q protoporphyrinogen oxidase FOW48_11910 ENOG41068WN FOW48_11920 ENOG4105VEQ Cold shock protein FOW48_11940 ENOG410667J hydrolase FOW48_11960 ENOG4107V2S Transcriptional regulator FOW48_11965 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOW48_11980 ENOG4105DND Transcriptional regulator FOW48_11985 ENOG4108RPX mosc domain containing protein FOW48_12000 ENOG4105BZ1 (ABC) transporter FOW48_12005 ENOG4105BZ1 (ABC) transporter FOW48_12025 ENOG4108JCI Transcriptional regulator FOW48_12070 ENOG4108KPJ rna polymerase sigma factor FOW48_12090 ENOG4105F32 YngK protein FOW48_12115 ENOG4105RD7 BadF BadG BcrA BcrD FOW48_12150 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FOW48_12165 ENOG4105C1J atp-dependent rna helicase FOW48_12205 ENOG41088CC tellurite resistance protein tehB FOW48_12275 ENOG4107RF6 penicillin-binding protein FOW48_12285 ENOG4105DIN metallophosphoesterase FOW48_12295 ENOG4105CJ1 ABC, transporter FOW48_12320 ENOG4105C1G acyl-Coa dehydrogenase FOW48_12325 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOW48_12330 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FOW48_12335 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FOW48_12340 ENOG4105E39 Enoyl-CoA hydratase FOW48_12345 ENOG4107QX3 carboxylase FOW48_12350 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOW48_12365 ENOG4105DBI uridine monophosphokinase FOW48_12390 ENOG4105T9C HD domain FOW48_12455 ENOG4107Y80 Major Facilitator superfamily FOW48_12510 ENOG4105CPQ Dehydrogenase FOW48_12515 ENOG410900G Protein of unknown function (DUF421) FOW48_12520 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FOW48_12535 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein FOW48_12545 ENOG4105DK7 lysyl-tRNA synthetase FOW48_12610 ENOG4105D6E homoserine dehydrogenase FOW48_12625 ENOG4105ETU transcriptional activator (TenA FOW48_12715 ENOG4107EV6 Inherit from COG: YD repeat protein FOW48_12795 ENOG4105BZU Histidine kinase FOW48_12800 ENOG4107RF6 penicillin-binding protein FOW48_12835 ENOG4108HGU Histidine kinase FOW48_12850 ENOG4105CB2 alcohol dehydrogenase FOW48_12855 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FOW48_12860 ENOG4105CJN penicillin-binding protein FOW48_12865 ENOG4108IG5 Transcriptional regulator FOW48_12870 ENOG4105CHR reductase FOW48_12935 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FOW48_12960 ENOG4107Y9U Membrane FOW48_12970 ENOG4105EGD dinuclear metal center protein, YbgI family FOW48_13005 ENOG4105E09 nadh pyrophosphatase FOW48_13010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FOW48_13015 ENOG4108Z4K mutator MutT protein FOW48_13050 ENOG4108XI2 Domain of unknown function (DUF1963) FOW48_13080 ENOG4105KWG Pfam:DUF1696 FOW48_13115 ENOG4105PKS Excinuclease abc c subunit domain protein FOW48_13150 ENOG4107VFR oxidoreductase FOW48_13175 ENOG4105U0R haloacid dehalogenase-like hydrolase FOW48_13195 ENOG4108IUM Glycogen debranching enzyme FOW48_13210 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FOW48_13215 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FOW48_13310 ENOG4107Z3H Transcriptional regulator, TetR family FOW48_13345 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FOW48_13360 ENOG4105E98 transcriptional regulator DeoR family FOW48_13380 ENOG4107QKR Dehydrogenase FOW48_13390 ENOG4107RUY (E1 component), alpha subunit FOW48_13405 ENOG4105RHY Pfam:UPF0157 FOW48_13445 ENOG4107SQ8 Glycine betaine FOW48_13450 ENOG4108IJ7 Glycine betaine FOW48_13475 ENOG4105E66 phosphoriboisomerase A FOW48_13480 ENOG41082BV acetyltransferase FOW48_13485 ENOG4108M1A Chitin-binding protein FOW48_13490 ENOG41087PP glycosyltransferase MGT family FOW48_13510 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOW48_13515 ENOG4105MSB protein, conserved in bacteria FOW48_13525 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FOW48_13545 ENOG4108Z7F N-acetyltransferase FOW48_13565 ENOG4105EEM helicase FOW48_13585 ENOG4105C9U ATP-dependent DNA helicase RecQ FOW48_13635 ENOG4108M1A Chitin-binding protein FOW48_13660 ENOG4105BZG amino acid carrier protein FOW48_13665 ENOG4105C26 Dehydrogenase FOW48_13670 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOW48_13675 ENOG4105CTU Proline racemase FOW48_13680 ENOG4105CTU Proline racemase FOW48_13685 ENOG41080HI glycine oxidase FOW48_13695 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FOW48_13730 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FOW48_13735 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FOW48_13750 ENOG4105DTQ mandelate racemase muconate lactonizing FOW48_13800 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FOW48_13805 ENOG4105BZU Histidine kinase FOW48_13810 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_13830 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FOW48_13845 ENOG4105DPN Oligoendopeptidase f FOW48_13855 ENOG4105EPR degv family FOW48_14115 ENOG4105KRN Transcriptional regulator, abrb family FOW48_14295 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FOW48_14300 ENOG4106K7D Major facilitator family transporter FOW48_14325 ENOG4107BMA Transglycosylase associated protein FOW48_14385 ENOG4108ZMI UPF0477 protein FOW48_14440 ENOG4105C02 permease FOW48_14450 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FOW48_14455 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FOW48_14460 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FOW48_14505 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FOW48_14550 ENOG4107VC0 DNA alkylation repair enzyme FOW48_14570 ENOG4107VMI polysaccharide deacetylase FOW48_14580 ENOG4108ZCF integral membrane protein FOW48_14585 ENOG4105E0M Sulfatase FOW48_14595 ENOG4105C5H ABC transporter FOW48_14605 ENOG4105EYF MMPL domain protein FOW48_14615 ENOG41082JN Transcriptional regulator FOW48_14635 ENOG4105CIH Imidazole acetol-phosphate transaminase FOW48_14645 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FOW48_14690 ENOG4105D4B ABC, transporter FOW48_14700 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FOW48_14710 ENOG4105DKT Transcriptional regulator FOW48_14715 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FOW48_14725 ENOG41061GT Aldolase FOW48_14735 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FOW48_14765 ENOG4105II7 pyrroline-5-carboxylate reductase FOW48_14775 ENOG4107258 Transcriptional regulator FOW48_14790 ENOG4105E0Y RtcB Protein FOW48_14795 ENOG4105ECK Fatty Acid Desaturase FOW48_14815 ENOG4105VMP Transcriptional regulator FOW48_14830 ENOG41090T1 Membrane FOW48_14840 ENOG4108WCX response regulator FOW48_14850 ENOG4105KNA -acetyltransferase FOW48_14875 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOW48_14895 ENOG4105C8Y Acetylornithine aminotransferase FOW48_14905 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FOW48_14925 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FOW48_14955 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FOW48_14965 ENOG4108TVJ Nitroreductase FOW48_14970 ENOG4105FS7 Transcriptional regulator FOW48_15010 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOW48_15050 ENOG4108XET gCN5-related N-acetyltransferase FOW48_15065 ENOG4108PCN EamA-like transporter family FOW48_15135 ENOG4105F1N DNA alkylation repair FOW48_15175 ENOG4107RF6 penicillin-binding protein FOW48_15215 ENOG4105P4J Allophanate hydrolase, subunit 1 FOW48_15220 ENOG4107258 Transcriptional regulator FOW48_15230 ENOG4106N3A copper homeostasis protein cutc FOW48_15235 ENOG4108ZRV stage ii sporulation protein p FOW48_15240 ENOG4108ZHR arsR family transcriptional regulator FOW48_15250 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_15260 ENOG4105FDT acyl-CoA dehydrogenase FOW48_15275 ENOG4105DWD nucleoside recognition domain protein FOW48_15315 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FOW48_15380 ENOG4105E2A Dehydrogenase FOW48_15390 ENOG4108IJ0 Aspartate ammonia-lyase FOW48_15395 ENOG4105HDK L-asparaginase FOW48_15400 ENOG4108IMY Transcriptional regulator FOW48_15405 ENOG4105DQ6 Transposase FOW48_15410 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FOW48_15415 ENOG4105CUB amino acid FOW48_15420 ENOG4105II7 pyrroline-5-carboxylate reductase FOW48_15425 ENOG4108NHD germination protein FOW48_15430 ENOG4108Q8B Spore germination protein FOW48_15455 ENOG4105CSV Glutaminase FOW48_15500 ENOG4107QTZ amino acid FOW48_15505 ENOG4105CGH 5'-nucleotidase FOW48_15510 ENOG4105CH6 catalase FOW48_15570 ENOG4108606 TspO/MBR family FOW48_15575 ENOG4105CVP deoxyribo-dipyrimidine photolyase FOW48_15600 ENOG4108TWJ NADH dehydrogenase subunit 5 FOW48_15605 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FOW48_15620 ENOG4105E1K spore germination protein FOW48_15630 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOW48_15670 ENOG4105DET Rhamnulokinase FOW48_15675 ENOG4107W7X Aldolase FOW48_15685 ENOG4105CNN ABC, transporter FOW48_15695 ENOG4105NWF RbsD or FucU transport FOW48_15700 ENOG4105ETE Transcriptional regulator (LacI family FOW48_15715 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FOW48_15720 ENOG41085FC arsR family transcriptional regulator FOW48_15730 ENOG4105NAE bifunctional deaminase-reductase domain protein FOW48_15790 ENOG4107P5I polyketide synthase FOW48_15795 ENOG4108IG5 Transcriptional regulator FOW48_15800 ENOG4105F27 Major Facilitator FOW48_15805 ENOG4105M4P Tetr family transcriptional regulator FOW48_15810 ENOG4105CHR reductase FOW48_15815 ENOG4108YXU transcriptional regulator AsnC family FOW48_15850 ENOG4105N0V mono-oxygenase ydhR FOW48_15865 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FOW48_15930 ENOG4105K6H D-cysteine desulfhydrase FOW48_15960 ENOG4105W1Y Transcriptional regulator FOW48_15965 ENOG4105JQZ Methyltransferase FOW48_15985 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FOW48_16005 ENOG4105BZU Histidine kinase FOW48_16020 ENOG4108U05 Transcriptional regulator FOW48_16025 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FOW48_16035 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FOW48_16065 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FOW48_16100 ENOG41082W1 Cupin 2, conserved barrel domain protein FOW48_16110 ENOG410874W AraC family transcriptional regulator FOW48_16135 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOW48_16175 ENOG4108ISG Major Facilitator FOW48_16190 ENOG4107MII Sugar-specific transcriptional regulator TrmB FOW48_16195 ENOG4105CZM Major Facilitator FOW48_16215 ENOG41069JR FOW48_16225 ENOG4105RXJ FOW48_16230 ENOG4105KPY Small multidrug resistance protein FOW48_16250 ENOG4105CRW Short chain fatty acid transporter FOW48_16260 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOW48_16360 ENOG4105EKQ RNA-directed DNA polymerase FOW48_16370 ENOG4105RHY Pfam:UPF0157 FOW48_16375 ENOG4108Z66 YbaK ebsC protein FOW48_16395 ENOG4105KVH Transcriptional regulator FOW48_16400 ENOG4108RCM Nitroreductase FOW48_16420 ENOG4108PSK reductase FOW48_16430 ENOG4105CJ1 ABC, transporter FOW48_16485 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FOW48_16490 ENOG4105DKQ ROK family FOW48_16495 ENOG4108UW5 maltose o-acetyltransferase FOW48_16500 ENOG4105C31 Tryptophanyl-tRNA synthetase FOW48_16535 ENOG4105DMQ Methyltransferase FOW48_16545 ENOG4105EV4 Multidrug resistance protein mdtH FOW48_16570 ENOG4105C37 (CBS) domain FOW48_16585 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FOW48_16590 ENOG4105FAW cDP-glucose 4,6-dehydratase FOW48_16620 ENOG4105DDN Pentapeptide repeat-containing protein FOW48_16625 ENOG4105XDF Protein of unknown function (DUF1272) FOW48_16630 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FOW48_16635 ENOG4105CMG Carbohydrate kinase FOW48_16645 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FOW48_16665 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FOW48_16670 ENOG4105CIS alcohol dehydrogenase FOW48_16675 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FOW48_16690 ENOG4105EWI Short-chain dehydrogenase reductase Sdr FOW48_16705 ENOG4105CV8 reductase FOW48_16710 ENOG4105F27 Major Facilitator FOW48_16725 ENOG4105C44 Serine transporter FOW48_16735 ENOG4105EKQ RNA-directed DNA polymerase FOW48_16775 ENOG4108TZY GntR Family Transcriptional Regulator FOW48_16780 ENOG4105D9R oxidoreductase FOW48_16785 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FOW48_16790 ENOG4105KVH Transcriptional regulator FOW48_16795 ENOG4105KVH Transcriptional regulator FOW48_16835 ENOG4105JAB phenazine biosynthesis protein, phzf family FOW48_16845 ENOG4105CHR reductase FOW48_16860 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FOW48_16865 ENOG4105KVH Transcriptional regulator FOW48_16950 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FOW48_16990 ENOG4105H3G oxidoreductase FOW48_17035 ENOG4105K7K Transcriptional regulator FOW48_17040 ENOG4105CIS alcohol dehydrogenase FOW48_17070 ENOG4108TN2 lmbE family FOW48_17080 ENOG4107R3E Citrate transporter FOW48_17095 ENOG4108MES Periplasmic binding protein FOW48_17100 ENOG4105EHG Permease protein FOW48_17105 ENOG4105DQ5 transport system permease protein FOW48_17110 ENOG4105NX3 Membrane FOW48_17130 ENOG4107CUJ Protein of unknown function (DUF2690) FOW48_17140 ENOG4107V2S Transcriptional regulator FOW48_17160 ENOG4105C98 muts2 protein FOW48_17165 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FOW48_17170 ENOG4105DPN Oligoendopeptidase f FOW48_17215 ENOG41082BM Transcriptional regulator, arsr family FOW48_17220 ENOG4105CIS alcohol dehydrogenase FOW48_17230 ENOG4107JM4 Tetratricopeptide repeat FOW48_17255 ENOG4105C09 Bile acid FOW48_17260 ENOG4105CQB FAD linked oxidase domain protein FOW48_17295 ENOG4105KT7 mgtC SapB transporter FOW48_17310 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOW48_17325 ENOG4108HW4 amino acid AbC transporter FOW48_17330 ENOG41073R8 VanW family FOW48_17340 ENOG4108R1P FOW48_17355 ENOG4105VEQ Cold shock protein FOW48_17375 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FOW48_17395 ENOG410904N short-chain dehydrogenase reductase FOW48_17405 ENOG4106IQC argininosuccinate lyase FOW48_17420 ENOG4108IA2 Sodium pantothenate symporter FOW48_17470 ENOG4105CHR reductase FOW48_17480 ENOG4105EWU Squalene--hopene cyclase FOW48_17490 ENOG4105FR1 rard protein FOW48_17495 ENOG410696E Membrane FOW48_17510 ENOG4105D1F ATP-binding protein FOW48_17520 ENOG4108ZAF Molybdopterin FOW48_17525 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOW48_17530 ENOG4105D06 uba thif-type nad fad binding protein FOW48_17535 ENOG4105TMB Formate nitrite transporter FOW48_17545 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FOW48_17550 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FOW48_17560 ENOG4108JB9 formate dehydrogenase FOW48_17565 ENOG4105E1K spore germination protein FOW48_17630 ENOG4107QJT sodium dicarboxylate symporter FOW48_17635 ENOG4108KGH TRANSCRIPTIONal FOW48_17645 ENOG4105EMN RNA polymerase sigma factor FOW48_17660 ENOG4105CIG ABC transporter FOW48_17670 ENOG4105D9R oxidoreductase FOW48_17680 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FOW48_17685 ENOG4105K4P CoA-binding domain protein FOW48_17690 ENOG4105C0H protease FOW48_17695 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_17705 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FOW48_17715 ENOG4105W8X HesB YadR YfhF-family protein FOW48_17745 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOW48_17755 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FOW48_17765 ENOG4105BZ1 (ABC) transporter FOW48_17770 ENOG4108I0Z Aconitate hydratase FOW48_17800 ENOG4105E5W Transporter FOW48_17800 ENOG4105E5W Transporter FOW48_17825 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FOW48_17860 ENOG4107ZYJ bioY protein FOW48_17865 ENOG4105CEY Amp-dependent synthetase and ligase FOW48_17925 ENOG4107AYK membrAne FOW48_17945 ENOG4105FBA Phospholipase Carboxylesterase FOW48_17950 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FOW48_17955 ENOG4105CK7 Sodium proline symporter FOW48_17970 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FOW48_17975 ENOG4108VJ1 Transcriptional regulator (CarD family FOW48_17980 ENOG4108903 Formimidoylglutamase FOW48_18015 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FOW48_18060 ENOG4105EKQ RNA-directed DNA polymerase FOW48_18075 ENOG4107QIV Cytochrome c biogenesis protein FOW48_18090 ENOG4105CH2 amidohydrolase FOW48_18100 ENOG4105CJ1 ABC, transporter FOW48_18115 ENOG4107RSM transcriptional regulator FOW48_18125 ENOG41067MG lrgb family FOW48_18150 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FOW48_18165 ENOG4105BZ1 (ABC) transporter FOW48_18170 ENOG4105BZ1 (ABC) transporter FOW48_18265 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOW48_18300 ENOG4105D5T phosphonate abc transporter FOW48_18305 ENOG4108HW3 (ABC) transporter FOW48_18310 ENOG4105CGH 5'-nucleotidase FOW48_18320 ENOG4108SVB resolvase FOW48_18340 ENOG4105K7K Transcriptional regulator FOW48_18345 ENOG4105C5F glutamine synthetase FOW48_18350 ENOG4105KV4 Transcriptional regulator FOW48_18355 ENOG4105CXI aluminum resistance protein FOW48_18360 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FOW48_18365 ENOG4105EN6 Membrane FOW48_18370 ENOG4106F1P AAA ATPase, central domain protein FOW48_18400 ENOG41069ER domain protein FOW48_18405 ENOG4105DM4 PTS System FOW48_18410 ENOG4105DE4 1-phosphofructokinase FOW48_18415 ENOG4105E98 transcriptional regulator DeoR family FOW48_18420 ENOG4107QW4 alcohol dehydrogenase FOW48_18425 ENOG4108SJC Membrane FOW48_18435 ENOG4105C85 amino acid FOW48_18455 ENOG4105TMB Formate nitrite transporter FOW48_18460 ENOG4105K70 DNA-binding protein FOW48_18470 ENOG4105C59 p-type ATPase FOW48_18475 ENOG410681U heavy metal transport detoxification protein FOW48_18480 ENOG4105VPX protein, conserved in bacteria FOW48_18490 ENOG4105NIV Esterase FOW48_18495 ENOG4105E0A ABC, transporter FOW48_18525 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FOW48_18530 ENOG4105D03 DNA-3-methyladenine glycosylase II FOW48_18605 ENOG4105E0M Sulfatase FOW48_18610 ENOG410890F Dynamin family FOW48_18620 ENOG4107QHE Choloylglycine hydrolase FOW48_18645 ENOG4105DA5 (ABC) transporter FOW48_18685 ENOG4105DQU oxidoreductase, subunit beta FOW48_18690 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FOW48_18700 ENOG4105MCT stage V sporulation protein S FOW48_18705 ENOG4105D48 metallophosphoesterase FOW48_18710 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FOW48_18730 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FOW48_18745 ENOG4105XZV Protein of unknown function (DUF3243) FOW48_18750 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FOW48_18770 ENOG4105UIB (ABC) transporter FOW48_18775 ENOG4108JQ9 ABC transporter FOW48_18780 ENOG4105DIH basic membrane FOW48_18785 ENOG4105FDP GntR family transcriptional regulator FOW48_18795 ENOG4107QZI cell division protein FtsK FOW48_18805 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FOW48_18815 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FOW48_18825 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FOW48_18830 ENOG4108S0H Dipicolinic acid synthetase, b subunit FOW48_18835 ENOG4105E35 Dipicolinate synthase subunit A FOW48_18865 ENOG4105DTN riboflavin biosynthesis protein ribF FOW48_18880 ENOG4105W7A Protein of unknown function (DUF503) FOW48_18890 ENOG4105VHM ribosomal protein FOW48_18895 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FOW48_18900 ENOG4105CHV Transcription elongation factor NusA FOW48_18910 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FOW48_18920 ENOG4105DZP Membrane-associated zinc metalloprotease FOW48_18930 ENOG4105KNE Phosphatidate cytidylyltransferase FOW48_18975 ENOG4108HE4 integrase family FOW48_18985 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FOW48_18990 ENOG4105C79 DNA protecting protein DprA FOW48_18995 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FOW48_19010 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FOW48_19035 ENOG4105VB6 UPF0109 protein FOW48_19055 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FOW48_19060 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FOW48_19075 ENOG4105CHR reductase FOW48_19095 ENOG4105CB5 ATP-dependent DNA helicase recG FOW48_19100 ENOG4105DP4 dak2 domain fusion protein ylov FOW48_19105 ENOG4108ZAA Alkaline-shock protein FOW48_19120 ENOG4105FJ0 thiamine FOW48_19125 ENOG4105DJV ribulose-phosphate 3-epimerase FOW48_19135 ENOG4105D9P serine threonine protein kinase FOW48_19140 ENOG4108ZF3 Phosphatase FOW48_19150 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FOW48_19160 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOW48_19165 ENOG4105C25 Primosomal protein n' FOW48_19170 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FOW48_19190 ENOG4105DSJ YicC domain protein FOW48_19200 ENOG4105F23 Fibronectin-binding protein FOW48_19295 ENOG4105C34 Pseudouridine synthase FOW48_19320 ENOG4105DBK s4 domain protein FOW48_19325 ENOG41067XK integral membrane protein FOW48_19335 ENOG4105DFA alanine racemase domain protein FOW48_19340 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FOW48_19345 ENOG4105WR5 sporulation protein, YlmC YmxH family FOW48_19355 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOW48_19365 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FOW48_19370 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FOW48_19375 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FOW48_19390 ENOG4105CNI cell division protein FtsW FOW48_19405 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FOW48_19415 ENOG4105CJN penicillin-binding protein FOW48_19420 ENOG41068DC Essential cell division protein (By similarity) FOW48_19455 ENOG4105KNH Nucleic acid-binding protein FOW48_19580 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOW48_19590 ENOG4105CAR Terminase, large subunit FOW48_19705 ENOG4108IMY Transcriptional regulator FOW48_19730 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) FOW48_19740 ENOG41063PX domain protein FOW48_19745 ENOG4105D78 K07001 NTE family protein FOW48_19750 ENOG4105H20 Sporulation integral membrane protein YlbJ FOW48_19760 ENOG4106H78 methyltransferase FOW48_19790 ENOG4107TB6 phosphoglycerate mutase FOW48_19805 ENOG4106UY4 Inherit from COG: Scp-like extracellular FOW48_19820 ENOG4105EKQ RNA-directed DNA polymerase FOW48_19865 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FOW48_19875 ENOG4105CNI cell division protein FtsW FOW48_19890 ENOG4108IAB Phoh family FOW48_19910 ENOG4105QA2 FOW48_19915 ENOG4105CI3 gtp-binding protein typa FOW48_19925 ENOG4105ECY inositol monophosphatase FOW48_19945 ENOG4105CXN decarboxylase FOW48_19995 ENOG4105CPP Dehydrogenase, E1 component FOW48_20010 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FOW48_20015 ENOG4108X4Q Hydrolase FOW48_20030 ENOG4105CN5 Metallo-Beta-Lactamase FOW48_20035 ENOG4107ZYR domain protein FOW48_20070 ENOG4108XRC Protein of unknown function (DUF458) FOW48_20075 ENOG4107IN1 Protein of unknown function (DUF1797) FOW48_20090 ENOG4105EPM Diguanylate phosphodiesterase FOW48_20095 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FOW48_20120 ENOG4105UIN FOW48_20185 ENOG4108HGU Histidine kinase FOW48_20195 ENOG4105CHM Aminotransferase FOW48_20200 ENOG4105FKQ transcriptional regulator FOW48_20205 ENOG4105EG2 ABC transporter, permease FOW48_20215 ENOG4107FKK extracellular solute-binding protein family 1 FOW48_20225 ENOG4105CG3 alpha amylase, catalytic region FOW48_20270 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FOW48_20275 ENOG4105CHU acetyl-coa acetyltransferase FOW48_20310 ENOG4105K7K Transcriptional regulator FOW48_20315 ENOG4105DTD Dehydrogenase FOW48_20385 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FOW48_20395 ENOG4106TD9 Diguanylate cyclase FOW48_20415 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FOW48_20430 ENOG4105CID antiterminator FOW48_20440 ENOG4105FDP GntR family transcriptional regulator FOW48_20450 ENOG4105CE4 GlcNAc 6-P deacetylase FOW48_20495 ENOG4107ZE5 PPIases accelerate the folding of proteins FOW48_20500 ENOG4105PTM secreted protein FOW48_20505 ENOG4105J7I hydrolase FOW48_20515 ENOG4105G6R Stage v sporulation protein ae FOW48_20525 ENOG4105CZ3 stage V sporulation protein ad FOW48_20530 ENOG41090VF Stage v sporulation protein ac FOW48_20550 ENOG4105C8J )-transporter FOW48_20555 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOW48_20565 ENOG41082AN stage II sporulation protein FOW48_20570 ENOG4105DZ1 carboxypeptidase FOW48_20580 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOW48_20585 ENOG4105DVE abc transporter atp-binding protein FOW48_20615 ENOG4105D7N magnesium and cobalt transport protein CorA FOW48_20640 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FOW48_20650 ENOG4105I3K Ferric uptake regulator, Fur family FOW48_20655 ENOG4105MZ9 stage II sporulation protein m FOW48_20685 ENOG4105RHY Pfam:UPF0157 FOW48_20705 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FOW48_20715 ENOG4105ETE Transcriptional regulator (LacI family FOW48_20745 ENOG4108R6K riboflavin synthase, subunit alpha FOW48_20770 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOW48_20775 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FOW48_20790 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FOW48_20800 ENOG4105DFD Na H antiporter FOW48_20805 ENOG4105CGH 5'-nucleotidase FOW48_20860 ENOG4108IXY short-chain dehydrogenase reductase FOW48_20865 ENOG41069FQ Metallo-beta-lactamase superfamily FOW48_20870 ENOG4105II7 pyrroline-5-carboxylate reductase FOW48_20875 ENOG4105EJQ L-serine dehydratase FOW48_20905 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FOW48_20915 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FOW48_20930 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FOW48_20935 ENOG4108QEG Membrane FOW48_20940 ENOG4105CDA abc transporter atp-binding protein FOW48_20945 ENOG4105E5Q amino acid AbC transporter FOW48_20950 ENOG4108HW3 (ABC) transporter FOW48_20970 ENOG4108QY0 Membrane FOW48_20980 ENOG4105C7S Dehydrogenase FOW48_20985 ENOG4105CPP Dehydrogenase, E1 component FOW48_21005 ENOG4107RDP Dehydrogenase FOW48_21015 ENOG4108JUB Transcriptional regulator FOW48_21035 ENOG4107QQR Sporulation FOW48_21045 ENOG4105S1Z Stage IV sporulation protein B FOW48_21050 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FOW48_21060 ENOG4105DX0 Hemolysin A FOW48_21070 ENOG4105CTB Polyprenyl synthetase FOW48_21095 ENOG4108ZSR alkaline shock protein FOW48_21100 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FOW48_21125 ENOG410644B Stage III sporulation protein af FOW48_21135 ENOG4105KQ4 Stage iii sporulation protein ad FOW48_21140 ENOG4108CQH stage III sporulation protein AC FOW48_21145 ENOG4105KR5 Stage iii sporulation protein FOW48_21150 ENOG4105CD2 stage iii sporulation protein aa FOW48_21190 ENOG4105CBJ Metal-dependent enzyme FOW48_21230 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FOW48_21235 ENOG4105WZW rhodanese family FOW48_21255 ENOG41080TC multidrug resistance protein FOW48_21290 ENOG4105CJ1 ABC, transporter FOW48_21295 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FOW48_21325 ENOG4105C0D helicase FOW48_21450 ENOG4105C3R Methionine synthase FOW48_21460 ENOG4105C28 cystathionine FOW48_21465 ENOG4105C28 cystathionine FOW48_21485 ENOG4105C5X domain protein FOW48_21495 ENOG4105DKQ ROK family FOW48_21505 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FOW48_21520 ENOG4108UTW Plays a role in the regulation of phosphate uptake FOW48_21525 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FOW48_21530 ENOG4105E2Z phosphate ABC transporter (Permease FOW48_21535 ENOG4105C8U phosphate abc transporter FOW48_21540 ENOG4105PWN phosphate abc transporter FOW48_21545 ENOG4107RF6 penicillin-binding protein FOW48_21555 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FOW48_21580 ENOG4105N80 Ferric uptake regulator, Fur family FOW48_21590 ENOG4105FDK ABC transporter FOW48_21595 ENOG4108JYZ YitT family FOW48_21600 ENOG41069ZM Protein of unknown function (DUF2624) FOW48_21625 ENOG4105EGD dinuclear metal center protein, YbgI family FOW48_21640 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOW48_21645 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FOW48_21670 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FOW48_21675 ENOG4105KG3 cytidine deaminase FOW48_21680 ENOG4107YR5 Diacylglycerol kinase FOW48_21695 ENOG4105C9A Phoh family FOW48_21705 ENOG41068P3 sporulation protein YqfC FOW48_21710 ENOG4105KTH gatB Yqey FOW48_21720 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FOW48_21725 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FOW48_21760 ENOG4105KVH Transcriptional regulator FOW48_21785 ENOG4105TQK DNA polymerase iii, delta' subunit FOW48_21800 ENOG4108UK2 deaminase FOW48_21805 ENOG4105KQC Competence protein FOW48_21815 ENOG4105DXX methyltransferase FOW48_21825 ENOG4108WF2 Metal Dependent Phosphohydrolase FOW48_21835 ENOG410812S Rna-binding protein FOW48_21845 ENOG4105CQW ribosome biogenesis GTPase YqeH FOW48_21850 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FOW48_21865 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOW48_21895 ENOG4105G6Z alkaline phosphatase FOW48_21900 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FOW48_21905 ENOG4108MUZ hydrolase FOW48_21940 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOW48_21945 ENOG4105MIR Phenylalanine 4-monooxygenase FOW48_21955 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FOW48_21995 ENOG4105S6R Iron-hydroxamate transporter permease subunit FOW48_22000 ENOG4108HUF Transporter FOW48_22015 ENOG4105C28 cystathionine FOW48_22060 ENOG4105CFP Peptidase U32 FOW48_22065 ENOG4105XYU peptidase (U32 family) FOW48_22070 ENOG4108VQJ O-methyltransferase FOW48_22075 ENOG4105HHA aminodeoxychorismate lyase FOW48_22105 ENOG4105C02 permease FOW48_22120 ENOG41060CR FOW48_22125 ENOG4105C7H Helicase, RecD TraA family FOW48_22150 ENOG4105D1H recombination factor protein RarA FOW48_22155 ENOG4108VCI transcription factor, rsfa family FOW48_22170 ENOG4105CUZ uba thif-type nad fad binding protein FOW48_22195 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FOW48_22205 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FOW48_22210 ENOG41076HS cation diffusion facilitator family transporter FOW48_22215 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FOW48_22225 ENOG4105CKP Polysaccharide Biosynthesis Protein FOW48_22230 ENOG4108QG2 Membrane FOW48_22240 ENOG4105VIE preprotein translocase, subunit YajC FOW48_22255 ENOG41061AI Protein of unknown function (DUF2905) FOW48_22315 ENOG4108RPX mosc domain containing protein FOW48_22340 ENOG4105EWM Histidine kinase FOW48_22370 ENOG4105C03 ribonuclease FOW48_22385 ENOG4107QMS site-determining protein FOW48_22400 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FOW48_22405 ENOG4105DFF Rod shape-determining protein mreb FOW48_22430 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FOW48_22465 ENOG4105D52 delta-aminolevulinic acid dehydratase FOW48_22490 ENOG4105K56 Transcriptional regulator FOW48_22510 ENOG4108IUQ atp-dependent protease FOW48_22540 ENOG4108QCI YvbH-like oligomerisation region FOW48_22560 ENOG4105M59 Phosphodiesterase, mj0936 family FOW48_22565 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FOW48_22575 ENOG4108XJQ germination protein FOW48_22585 ENOG4108PCX Major Facilitator FOW48_22595 ENOG4105KBX Transcriptional regulator, TetR family FOW48_22610 ENOG4105PFC Transcriptional regulator FOW48_22620 ENOG4105DZC cytosine deaminase FOW48_22625 ENOG41067S9 phage shock protein C, PspC FOW48_22640 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FOW48_22645 ENOG4108Z40 Transcriptional regulator FOW48_22650 ENOG4105RHA ABC transporter, permease FOW48_22655 ENOG4108IUX (ABC) transporter FOW48_22660 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FOW48_22665 ENOG4105ER2 Ompa motb domain protein FOW48_22670 ENOG4105E14 MotA TolQ exbB proton channel FOW48_22675 ENOG4108VXD carboxy-peptidase FOW48_22685 ENOG4105E33 succinate dehydrogenase FOW48_22695 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FOW48_22710 ENOG4105K63 Thioredoxin FOW48_22715 ENOG4105C10 Electron transfer flavoprotein FOW48_22720 ENOG4105BZJ Electron transfer flavoprotein FOW48_22725 ENOG41060WC Enoyl-CoA hydratase FOW48_22730 ENOG4107Z3H Transcriptional regulator, TetR family FOW48_22735 ENOG4105CEY Amp-dependent synthetase and ligase FOW48_22775 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOW48_22800 ENOG4105KFN sortase, SrtB family FOW48_22805 ENOG4105E0A ABC, transporter FOW48_22820 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FOW48_22825 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FOW48_22835 ENOG4105FE9 pseudouridine synthase FOW48_22845 ENOG4105DCG PHP domain protein FOW48_22895 ENOG4108RWN rrna methyltransferase FOW48_22915 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_22920 ENOG4105CW7 secretion protein, HlyD family FOW48_22930 ENOG4105CN9 Peptidase m42 family protein FOW48_22950 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FOW48_22955 ENOG4105C22 threonyL-tRNA synthetase FOW48_22960 ENOG4108TDW sporulation protein YtxC FOW48_22980 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FOW48_22985 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FOW48_22990 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FOW48_23005 ENOG4105C2M dna polymerase I FOW48_23015 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOW48_23035 ENOG4108HMX isocitrate dehydrogenase (NADP) FOW48_23040 ENOG4105BZN citrate synthase FOW48_23055 ENOG4108REF Sporulation integral membrane protein ytvi FOW48_23060 ENOG4105FS0 cytoplasmic membrane protein FOW48_23085 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FOW48_23090 ENOG4105C6K Malic enzyme FOW48_23095 ENOG4105C0B DNA polymerase III (alpha subunit) FOW48_23100 ENOG4105VV2 FOW48_23110 ENOG4105SFS phosphoesterase RecJ domain protein FOW48_23150 ENOG4105DC7 peptidase M24 FOW48_23185 ENOG4105Z7P Acetyltransferase (GNAT) family FOW48_23190 ENOG41082W1 Cupin 2, conserved barrel domain protein FOW48_23210 ENOG4107YZX Universal stress protein FOW48_23275 ENOG4108JYZ YitT family FOW48_23305 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FOW48_23310 ENOG4105KBJ sporulation protein ytfj FOW48_23325 ENOG4105EFZ amidohydrolase FOW48_23335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FOW48_23360 ENOG4105C5Q Transcriptional regulator FOW48_23370 ENOG4105U5Y Transcriptional regulator FOW48_23380 ENOG4105C28 cystathionine FOW48_23410 ENOG4105EMN RNA polymerase sigma factor FOW48_23430 ENOG4105F1V Acetoin utilization protein FOW48_23435 ENOG4105W87 Cbs domain FOW48_23455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FOW48_23465 ENOG4105EP9 oxidoreductase FOW48_23495 ENOG4105ETE Transcriptional regulator (LacI family FOW48_23520 ENOG4105C88 aminopeptidase FOW48_23565 ENOG4108VDD TRNA binding domain protein FOW48_23595 ENOG4105C8F Beta-lactamase domain protein FOW48_23610 ENOG4108V15 phosphotransferase enzyme family FOW48_23615 ENOG4108IUM Glycogen debranching enzyme FOW48_23625 ENOG4107QSE Dipeptidase FOW48_23630 ENOG4105YW5 deoR family transcriptional regulator FOW48_23645 ENOG4105CBX hi0933 family FOW48_23685 ENOG4108VJ1 Transcriptional regulator (CarD family FOW48_23690 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FOW48_23710 ENOG4108ZAF Molybdopterin FOW48_23715 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FOW48_23720 ENOG4105CVM Molybdenum cofactor synthesis domain protein FOW48_23730 ENOG4105D06 uba thif-type nad fad binding protein FOW48_23735 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FOW48_23760 ENOG41085GJ domain protein FOW48_23770 ENOG4105DWV Homoserine O-trans-acetylase FOW48_23780 ENOG4108B31 Spore germination protein FOW48_23810 ENOG410605W Major Facilitator FOW48_23815 ENOG4107S91 Sodium hydrogen exchanger FOW48_23820 ENOG4105NCW Trka-c domain protein FOW48_23840 ENOG4105C19 ABC transporter FOW48_23860 ENOG4105N5T Radical SAM Protein FOW48_23875 ENOG4105CIG ABC transporter FOW48_23915 ENOG4105E8V Alpha Beta Hydrolase Fold protein FOW48_23920 ENOG4108Z0R Transferase FOW48_23925 ENOG4105YVM Phosphoesterase, PA-phosphatase related FOW48_23930 ENOG4105BZF Glycosyl transferase (Group 1 FOW48_23940 ENOG4108RIR Molybdenum cofactor biosynthesis protein FOW48_23950 ENOG4108MK9 spermidine N(1)-acetyltransferase FOW48_23995 ENOG4105BZU Histidine kinase FOW48_24000 ENOG4105BZU Histidine kinase FOW48_24005 ENOG4107S9D Alpha beta hydrolase FOW48_24010 ENOG4107T7U Sulfatase FOW48_24030 ENOG4105D2X ABC transporter substrate-binding protein FOW48_24040 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FOW48_24100 ENOG4108V2W Carbonate dehydratase FOW48_24105 ENOG4105C4M (Ubiquinol oxidase) subunit I FOW48_24110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FOW48_24155 ENOG41087YS Phage shock protein A FOW48_24190 ENOG4105BZU Histidine kinase FOW48_24195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_24225 ENOG4108UGV hypoxanthine phosphoribosyltransferase FOW48_24230 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FOW48_24255 ENOG4105C19 ABC transporter FOW48_24270 ENOG4107ZTW SNARE associated Golgi FOW48_24295 ENOG4105C19 ABC transporter FOW48_24300 ENOG41086D8 Transcriptional regulator FOW48_24310 ENOG41082BM Transcriptional regulator, arsr family FOW48_24350 ENOG4105C6Z Gluconate FOW48_24355 ENOG4105FDP GntR family transcriptional regulator FOW48_24375 ENOG41069H0 dihydroorotase EC 3.5.2.3 FOW48_24395 ENOG4105DTQ mandelate racemase muconate lactonizing FOW48_24405 ENOG4108IPT Naphthoate synthase FOW48_24410 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FOW48_24420 ENOG4105E4F Isochorismate synthase FOW48_24425 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FOW48_24435 ENOG4105VEQ Cold shock protein FOW48_24485 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FOW48_24585 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FOW48_24620 ENOG4105KT7 mgtC SapB transporter FOW48_24625 ENOG4107PBV potassium channel FOW48_24645 ENOG4105WG9 Conserved Protein FOW48_24655 ENOG4105CHM Aminotransferase FOW48_24660 ENOG4108ZB6 transcriptional regulator AsnC family FOW48_24665 ENOG4105C5I Dehydrogenase FOW48_24670 ENOG4108MUZ hydrolase FOW48_24680 ENOG4105C87 Aminotransferase class I and II FOW48_24690 ENOG4105Y38 Kinase-associated protein B FOW48_24700 ENOG4107R3E Citrate transporter FOW48_24720 ENOG4105KA0 thioesterase Superfamily protein FOW48_24740 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FOW48_24760 ENOG41069ER domain protein FOW48_24775 ENOG4105CEP NADH dehydrogenase FOW48_24800 ENOG4105EWC Purine nucleoside phosphorylase FOW48_24820 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FOW48_24845 ENOG4108JJA ABC, transporter FOW48_24850 ENOG4105C4B ABC transporter, permease FOW48_24860 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FOW48_24905 ENOG41083MR nifu domain-containing protein FOW48_24920 ENOG4108W5N phosphatidylglycerophosphatase a FOW48_24930 ENOG4105DYS nad(p)h dehydrogenase (quinone) FOW48_24935 ENOG4105D4U had-superfamily hydrolase, subfamily iia FOW48_24950 ENOG4105CBT Fructose-1,6-bisphosphatase FOW48_24970 ENOG4105MMD transcriptional regulator FOW48_24975 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FOW48_24980 ENOG4107TXC Transcriptional regulator FOW48_24990 ENOG41090T1 Membrane FOW48_25015 ENOG4105FAA peptidase M23 FOW48_25025 ENOG4105KZD Domain of unknown function (DUF1805) FOW48_25030 ENOG4107R8B 5'-nucleotidase FOW48_25040 ENOG4105DIW FeS assembly protein SUFB FOW48_25045 ENOG4108UNV SUF system FeS assembly protein, NifU family FOW48_25050 ENOG4105C9B Cysteine desulfurase FOW48_25055 ENOG4105JRK feS assembly protein SufD FOW48_25060 ENOG4105C3K feS assembly ATPase SufC FOW48_25065 ENOG4105D01 (LipO)protein FOW48_25070 ENOG4105D01 (LipO)protein FOW48_25075 ENOG4108UMI ABC transporter, permease FOW48_25110 ENOG41080E8 Transcriptional regulator, Spx MgsR family FOW48_25185 ENOG4108W8B Beta-lactamase domain protein FOW48_25190 ENOG4105C1G acyl-Coa dehydrogenase FOW48_25200 ENOG4105CHU acetyl-coa acetyltransferase FOW48_25220 ENOG4105DZ1 carboxypeptidase FOW48_25240 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOW48_25245 ENOG4105D7V transposase FOW48_25260 ENOG4105F27 Major Facilitator FOW48_25265 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FOW48_25295 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FOW48_25305 ENOG4107AYK membrAne FOW48_25340 ENOG4107ZTW SNARE associated Golgi FOW48_25350 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FOW48_25355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FOW48_25360 ENOG4105BZU Histidine kinase FOW48_25385 ENOG4105C8Q Methyl-accepting chemotaxis FOW48_25390 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FOW48_25395 ENOG4105VG1 fes assembly suf system protein FOW48_25400 ENOG4105D4Y metalloprotease FOW48_25425 ENOG4107S91 Sodium hydrogen exchanger FOW48_25430 ENOG4105NCW Trka-c domain protein FOW48_25450 ENOG4108RMU ferritin dps family protein FOW48_25470 ENOG4108URH decarboxylase FOW48_25490 ENOG4105D9N nucleoside FOW48_25495 ENOG4105D9N nucleoside FOW48_25510 ENOG4108RYK Nad-dependent epimerase dehydratase FOW48_25530 ENOG4105CV8 reductase FOW48_25540 ENOG4105KVH Transcriptional regulator FOW48_25555 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FOW48_25585 ENOG4105C8Q Methyl-accepting chemotaxis FOW48_25595 ENOG4105WMR Protein CrcB homolog FOW48_25620 ENOG4105C5H ABC transporter FOW48_25625 ENOG4108MK9 spermidine N(1)-acetyltransferase FOW48_25630 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FOW48_25640 ENOG4108IPW abc transporter atp-binding protein FOW48_25645 ENOG4105CM4 permease protein FOW48_25675 ENOG4105C19 ABC transporter FOW48_25695 ENOG4107ZTW SNARE associated Golgi FOW48_25740 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) FOW48_25745 ENOG41086D8 Transcriptional regulator FOW48_25760 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FOW48_25765 ENOG4105C0R drug resistance transporter emrb qaca subfamily FOW48_25775 ENOG4108ZHR arsR family transcriptional regulator FOW48_25780 ENOG4105DHF Membrane FOW48_25820 ENOG4107RBB ABC transporter, permease FOW48_25825 ENOG4105C19 ABC transporter FOW48_25875 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FOW48_25885 ENOG4105XZU Preprotein translocase, subunit SecG FOW48_25890 ENOG41067MG lrgb family FOW48_25940 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FOW48_25960 ENOG41090VF Stage v sporulation protein ac FOW48_25965 ENOG4105CZ3 stage V sporulation protein ad FOW48_25980 ENOG4108QY0 Membrane FOW48_25985 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FOW48_25995 ENOG4105KRI phosphocarrier protein (HPr FOW48_26005 ENOG4105CHW UPF0052 protein FOW48_26015 ENOG4108Z4K mutator MutT protein FOW48_26025 ENOG4105C3M thioredoxin reductase FOW48_26035 ENOG4108S4C acetyltransferase FOW48_26055 ENOG41086DT Membrane protein of unknown function FOW48_26065 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FOW48_26080 ENOG4107TXC Transcriptional regulator FOW48_26115 ENOG4105DUM transcriptional regulator, lysR family FOW48_26125 ENOG4108WS4 fmn reductase FOW48_26130 ENOG4105C5H ABC transporter FOW48_26140 ENOG4105BZ1 (ABC) transporter FOW48_26150 ENOG4105CN1 protease FOW48_26155 ENOG4105CRP Part of the ABC transporter FtsEX involved in FOW48_26160 ENOG4105CAK Cell division ATP-binding protein ftsE FOW48_26180 ENOG4105MS2 ribosomal subunit Interface protein FOW48_26185 ENOG4105VEQ Cold shock protein FOW48_26190 ENOG41081UC Inherit from COG: Competence protein FOW48_26200 ENOG4105K4H Nlp p60 protein FOW48_26205 ENOG4105KVH Transcriptional regulator FOW48_26215 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FOW48_26220 ENOG4108KGH TRANSCRIPTIONal FOW48_26225 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FOW48_26230 ENOG4105C6Y Udp-glucose 6-dehydrogenase FOW48_26235 ENOG4105ESV Glycosyl transferase, family 4 FOW48_26245 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FOW48_26265 ENOG4105F8D glycoside hydrolase family 4 FOW48_26270 ENOG4105VCP PTS System FOW48_26275 ENOG4105CK1 PTS System FOW48_26285 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FOW48_26305 ENOG4105VCP PTS System FOW48_26315 ENOG4105VZJ PTS System FOW48_26335 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FOW48_26365 ENOG4107RSM transcriptional regulator FOW48_26395 ENOG4105DAA L-lactate FOW48_26405 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FOW48_26420 ENOG4105E0M Sulfatase FOW48_26540 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FOW48_26600 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOW48_26790 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein FOW48_26805 ENOG4105EKQ RNA-directed DNA polymerase FOW48_26870 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FOW48_26965 ENOG4105KRN Transcriptional regulator, abrb family FOW48_26970 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)