locus-tag class description FPL02_00045 ENOG4105EKQ RNA-directed DNA polymerase FPL02_00100 ENOG4105DHF Membrane FPL02_00140 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FPL02_00170 ENOG4105KRN Transcriptional regulator, abrb family FPL02_00205 ENOG4108IBT Inherit from COG: transposase FPL02_00270 ENOG4107R0E Glycosyl transferase, family 2 FPL02_00275 ENOG4107R0E Glycosyl transferase, family 2 FPL02_00295 ENOG41086D8 Transcriptional regulator FPL02_00320 ENOG4105K59 histidine triad (HIT) protein FPL02_00370 ENOG4105VMP Transcriptional regulator FPL02_00390 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL02_00410 ENOG41090VF Stage v sporulation protein ac FPL02_00415 ENOG4105CZ3 stage V sporulation protein ad FPL02_00430 ENOG4108QY0 Membrane FPL02_00435 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FPL02_00450 ENOG4108B31 Spore germination protein FPL02_00455 ENOG4105E1K spore germination protein FPL02_00485 ENOG4105C4W S-formylglutathione hydrolase FPL02_00495 ENOG4105D9M gamma-glutamylcysteine synthetase FPL02_00520 ENOG4108NHD germination protein FPL02_00535 ENOG4108W2Y isochorismatase FPL02_00550 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_00555 ENOG4105BZU Histidine kinase FPL02_00595 ENOG4105C5Y PTS System FPL02_00690 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FPL02_00820 ENOG4105EKQ RNA-directed DNA polymerase FPL02_00825 ENOG4105EKQ RNA-directed DNA polymerase FPL02_00850 ENOG4108M1A Chitin-binding protein FPL02_00890 ENOG4105K4H Nlp p60 protein FPL02_00925 ENOG41080HT Transcriptional regulator, arsr family FPL02_01080 ENOG4105EKQ RNA-directed DNA polymerase FPL02_01150 ENOG4105EKQ RNA-directed DNA polymerase FPL02_01160 ENOG4107QZI cell division protein FtsK FPL02_01190 ENOG4105D7V transposase FPL02_01230 ENOG4105D7V transposase FPL02_01295 ENOG4105D7V transposase FPL02_01430 ENOG41067XF inhibitor FPL02_01460 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain FPL02_01465 ENOG4105BZU Histidine kinase FPL02_01515 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FPL02_01520 ENOG41062M3 atp synthase FPL02_01550 ENOG4108YZG isomerase FPL02_01565 ENOG4108VGI doxx family FPL02_01570 ENOG4107XC4 flavin reductase domain protein, FMN-binding FPL02_01600 ENOG4108ZXQ stage ii sporulation protein r FPL02_01610 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FPL02_01625 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FPL02_01630 ENOG4105CBT Fructose-1,6-bisphosphatase FPL02_01635 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FPL02_01670 ENOG4105C1G acyl-Coa dehydrogenase FPL02_01675 ENOG4105C1G acyl-Coa dehydrogenase FPL02_01680 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FPL02_01690 ENOG4105DF6 Fe-S oxidoreductase FPL02_01735 ENOG4105BZU Histidine kinase FPL02_01740 ENOG4105KCT ABC transporter FPL02_01745 ENOG4108M15 ABC transporter FPL02_01750 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FPL02_01760 ENOG4105IIU Aminopeptidase FPL02_01780 ENOG4105EMN RNA polymerase sigma factor FPL02_01790 ENOG410684U Domain of unknown function (DUF1934) FPL02_01820 ENOG4105DXB Major Facilitator superfamily FPL02_01825 ENOG4107SWG transcriptional regulator MERR family FPL02_01830 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FPL02_01835 ENOG4105BZ4 penicillin-binding protein FPL02_01840 ENOG4108XFG YwhD family FPL02_01845 ENOG4108Z4T Peptidase M50 FPL02_01850 ENOG41069HH 4-oxalocrotonate tautomerase FPL02_01855 ENOG4105DCI Phosphohydrolase FPL02_01860 ENOG4108MES Periplasmic binding protein FPL02_01865 ENOG4105E0A ABC, transporter FPL02_01870 ENOG4105EHG Permease protein FPL02_01875 ENOG4105DQ5 transport system permease protein FPL02_01885 ENOG4108VCI transcription factor, rsfa family FPL02_01900 ENOG4108IJ2 phosphate acetyltransferase FPL02_01915 ENOG4108VKI Cell wall hydrolase FPL02_01935 ENOG4107SVH Potassium channel protein FPL02_01945 ENOG410667J hydrolase FPL02_01950 ENOG4105VCH membrane FPL02_01960 ENOG4108TU7 Inherit from COG: (ABC) transporter FPL02_01965 ENOG4105CJ1 ABC, transporter FPL02_01970 ENOG41090WU lipolytic protein G-D-S-L family FPL02_01985 ENOG4105D6E homoserine dehydrogenase FPL02_02005 ENOG4108Y4K DNA-binding transcriptional activator FPL02_02015 ENOG4105WH1 Two component transcriptional regulator luxr family FPL02_02020 ENOG4105BZU Histidine kinase FPL02_02025 ENOG4105DWF phosphomethylpyrimidine kinase FPL02_02030 ENOG4105BZU Histidine kinase FPL02_02035 ENOG4105VCD cytoplasmic protein FPL02_02040 ENOG4105D22 carbon starvation protein FPL02_02045 ENOG4105DY9 regulatoR FPL02_02050 ENOG41079KZ Major Facilitator Superfamily FPL02_02065 ENOG4105CG5 Glycosyl transferase (Group 1 FPL02_02075 ENOG4105EN6 Membrane FPL02_02080 ENOG4106YBV Methyl-accepting chemotaxis FPL02_02090 ENOG4108S4H thioesterase Superfamily protein FPL02_02095 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) FPL02_02110 ENOG4107S6X Glycosyl transferase, family 2 FPL02_02115 ENOG4105C5H ABC transporter FPL02_02120 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL02_02130 ENOG41067SE Tetr family transcriptional regulator FPL02_02140 ENOG4105E0X reductase FPL02_02150 ENOG4106F5Q Membrane FPL02_02165 ENOG4105DY9 regulatoR FPL02_02170 ENOG4108HRK Histidine kinase FPL02_02175 ENOG4107RGD Major Facilitator superfamily FPL02_02195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL02_02240 ENOG4105CMR udp-glucose 4-epimerase FPL02_02245 ENOG4108UT2 hemolysin iii FPL02_02255 ENOG4105C1J atp-dependent rna helicase FPL02_02265 ENOG4105DPN Oligoendopeptidase f FPL02_02285 ENOG4105C0H protease FPL02_02290 ENOG4105Q2H domain protein FPL02_02305 ENOG4105BZU Histidine kinase FPL02_02310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_02350 ENOG4105BZR domain protein FPL02_02355 ENOG4108XMW Membrane FPL02_02365 ENOG4108UUM single-stranded DNA-binding protein FPL02_02375 ENOG4105C3G gtp-binding protein FPL02_02380 ENOG4105VDK protein, conserved in bacteria FPL02_02385 ENOG4105D8X mechanosensitive ion channel FPL02_02390 ENOG4108ZDA Sporulation protein YyaC FPL02_02395 ENOG4105FA0 parb-like partition protein FPL02_02400 ENOG4107QJE Chromosome Partitioning Protein FPL02_02430 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FPL02_02450 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FPL02_02455 ENOG410848D S4 domain protein YaaA FPL02_02470 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL02_02505 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FPL02_02540 ENOG4105ZMH deoxynucleoside kinase FPL02_02550 ENOG4105GTG Isochorismatase FPL02_02555 ENOG4108Z6B deaminase FPL02_02565 ENOG4105C6E dna polymerase iii FPL02_02585 ENOG41067KS pro-sigma K processing FPL02_02620 ENOG4105CXN decarboxylase FPL02_02630 ENOG4105FA2 dna polymerase iii FPL02_02635 ENOG4105MA4 psp1 domain protein FPL02_02645 ENOG41060K3 Methyltransferase FPL02_02655 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FPL02_02660 ENOG4105KRN Transcriptional regulator, abrb family FPL02_02670 ENOG4105F8V Hydrolase, tatD family FPL02_02675 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) FPL02_02685 ENOG4105XFA sporulation peptidase YabG FPL02_02690 ENOG4105W42 Veg protein FPL02_02710 ENOG4105KME endoribonuclease L-psp FPL02_02725 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FPL02_02740 ENOG4108JA2 transcriptioN-repair coupling factor FPL02_02745 ENOG4108M14 stage v sporulation protein t FPL02_02755 ENOG4108IY2 MazG family FPL02_02760 ENOG41082I2 s4 domain protein FPL02_02765 ENOG4105VYY sporulation protein yabp FPL02_02780 ENOG41060GV RNA binding s1 domain protein FPL02_02805 ENOG4108UGV hypoxanthine phosphoribosyltransferase FPL02_02810 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FPL02_02825 ENOG4105C6T cysteine synthase FPL02_02830 ENOG4105CRQ synthase (Component I) FPL02_02835 ENOG4105DDQ anthranilate synthase FPL02_02840 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FPL02_02845 ENOG4105EEI dihydropteroate synthase FPL02_02850 ENOG4105KRF dihydroneopterin aldolase FPL02_02855 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FPL02_02865 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FPL02_02955 ENOG4108Z0C Uvrb UvrC protein FPL02_02970 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FPL02_02980 ENOG4105CTP PilT protein domain protein FPL02_03000 ENOG4105D7W serine acetyltransferase FPL02_03015 ENOG4105C2N RNA methyltransferase TrmH family group 3 FPL02_03020 ENOG4105M0M Tetracycline resistance protein FPL02_03025 ENOG4105QIV RNA polymerase FPL02_03040 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FPL02_03065 ENOG4107Y49 methyltransferase FPL02_03080 ENOG4105XPM ribosomal protein FPL02_03190 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FPL02_03215 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FPL02_03225 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL02_03235 ENOG41067V7 50S ribosomal protein L36 FPL02_03265 ENOG4108JJB ABC transporter FPL02_03270 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FPL02_03300 ENOG4105D1F ATP-binding protein FPL02_03315 ENOG4108NMV polysaccharide deacetylase FPL02_03395 ENOG4105C8B TIGR00159 family FPL02_03400 ENOG4107U5W ybbr family FPL02_03420 ENOG4108VQT Alpha beta hydrolase fold protein FPL02_03430 ENOG4105CMG Carbohydrate kinase FPL02_03440 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FPL02_03475 ENOG4108PSK reductase FPL02_03480 ENOG4108UMI ABC transporter, permease FPL02_03490 ENOG4105D01 (LipO)protein FPL02_03495 ENOG4105EE1 crotonyl-CoA reductase FPL02_03505 ENOG4105IQ5 FAD linked oxidase domain protein FPL02_03520 ENOG4105C2C drug resistance transporter, Bcr CflA FPL02_03540 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FPL02_03545 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL02_03550 ENOG4105C3U ABC transporter FPL02_03555 ENOG4108JQ7 (ABC) transporter FPL02_03585 ENOG4108J59 Extracellular solute-binding protein, family 5 FPL02_03590 ENOG4108J59 Extracellular solute-binding protein, family 5 FPL02_03600 ENOG4105II7 pyrroline-5-carboxylate reductase FPL02_03605 ENOG4107XDY Nicotinamide Mononucleotide Transporter FPL02_03615 ENOG4105E0C molybdate abc transporter FPL02_03620 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FPL02_03625 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family FPL02_03655 ENOG4105F6E Acyl-transferase FPL02_03675 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FPL02_03685 ENOG4108RE7 deoxyribonuclease FPL02_03695 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FPL02_03715 ENOG4105C5H ABC transporter FPL02_03725 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FPL02_03730 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FPL02_03740 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL02_03745 ENOG4105C3U ABC transporter FPL02_03750 ENOG4108JQ7 (ABC) transporter FPL02_03755 ENOG410667J hydrolase FPL02_03790 ENOG4105ERH Fumarylacetoacetate hydrolase FPL02_03800 ENOG4105CUB amino acid FPL02_03810 ENOG4105CPF Cell wall formation (By similarity) FPL02_03815 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FPL02_03840 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FPL02_03845 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FPL02_03855 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FPL02_03955 ENOG4105K8N protein family UPF0079, ATPase FPL02_03960 ENOG41072GX Peptidase M22 Glycoprotease FPL02_03965 ENOG410801F ribosomal-protein-alanine acetyltransferase FPL02_03975 ENOG4105C5H ABC transporter FPL02_03990 ENOG4108TYN CAAX amino terminal protease family protein FPL02_04010 ENOG4105C7N Xanthine uracil vitamin C permease FPL02_04020 ENOG4105BZU Histidine kinase FPL02_04050 ENOG4107ZXU DSBA oxidoreductase FPL02_04100 ENOG4108SHN Glycosyl transferase, family 2 FPL02_04125 ENOG4105SX7 Transporter FPL02_04150 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FPL02_04155 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FPL02_04160 ENOG4105C83 adenylosuccinate lyase FPL02_04170 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FPL02_04195 ENOG4108V3E phosphoribosylglycinamide formyltransferase FPL02_04205 ENOG4105C12 Phosphoribosylglycinamide synthetase FPL02_04230 ENOG4105C4R Atp-dependent dna helicase FPL02_04255 ENOG4108W2Y isochorismatase FPL02_04260 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FPL02_04265 ENOG4108UMI ABC transporter, permease FPL02_04270 ENOG4105D01 (LipO)protein FPL02_04290 ENOG410834F Transcriptional regulator FPL02_04295 ENOG4107I77 yiaA/B two helix domain FPL02_04315 ENOG4105CBD Diacylglycerol kinase FPL02_04320 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FPL02_04325 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FPL02_04330 ENOG4108JPW Aminotransferase FPL02_04340 ENOG4105C26 Dehydrogenase FPL02_04345 ENOG4105KPY Small multidrug resistance protein FPL02_04365 ENOG4105D9N nucleoside FPL02_04370 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FPL02_04385 ENOG4105BZU Histidine kinase FPL02_04390 ENOG4108W15 Protein of unknown function (DUF1456) FPL02_04405 ENOG4105DTQ mandelate racemase muconate lactonizing FPL02_04415 ENOG4105DFD Na H antiporter FPL02_04435 ENOG4105D3R alkyl hydroperoxide reductase FPL02_04440 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FPL02_04445 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FPL02_04450 ENOG4107W7X Aldolase FPL02_04455 ENOG4105EHG Permease protein FPL02_04460 ENOG4105DQ5 transport system permease protein FPL02_04465 ENOG4108V5C ABC transporter FPL02_04495 ENOG4106UIA FPL02_04500 ENOG4106UIA FPL02_04530 ENOG410756H nucleotidyltransferase FPL02_04560 ENOG4107QJZ Glycosyl transferase, family 2 FPL02_04570 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FPL02_04575 ENOG4105E5Q amino acid AbC transporter FPL02_04580 ENOG4105EAB amino acid AbC transporter FPL02_04595 ENOG4105C8Q Methyl-accepting chemotaxis FPL02_04600 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FPL02_04610 ENOG4105CI1 PTS System FPL02_04645 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FPL02_04660 ENOG4105Y36 Binding-protein-dependent transport systems, inner membrane component FPL02_04680 ENOG4105C5H ABC transporter FPL02_04710 ENOG41062JF Transcriptional regulator FPL02_04730 ENOG4105DEU major facilitator superfamily FPL02_04760 ENOG4108N0M stress protein FPL02_04765 ENOG4106FN3 tellurium resistance protein FPL02_04770 ENOG4106FN3 tellurium resistance protein FPL02_04775 ENOG4107TS3 membrane protein, TerC FPL02_04780 ENOG4108TTB tellurium resistance protein FPL02_04800 ENOG4105KJF protein tyrosine phosphatase FPL02_04810 ENOG4107U9T Pfam:Ribonuclease_BN FPL02_04815 ENOG4105C59 p-type ATPase FPL02_04820 ENOG4108IPJ Membrane FPL02_04830 ENOG4105C3F Signal peptidase i FPL02_04840 ENOG4107ZTW SNARE associated Golgi FPL02_04855 ENOG410606W general stress protein FPL02_04860 ENOG4105UPD Calcium Proton FPL02_04910 ENOG4108JUB Transcriptional regulator FPL02_04920 ENOG4108IQI permease FPL02_04945 ENOG4105CSV Glutaminase FPL02_04955 ENOG4108A04 Beta-lactamase FPL02_04975 ENOG4105CKK Glycosyl transferase, family 2 FPL02_04980 ENOG4107QQG Dehydrogenase FPL02_04985 ENOG4105C3I Nad-dependent epimerase dehydratase FPL02_05005 ENOG4105F1A Pyruvate formate-lyase FPL02_05025 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FPL02_05030 ENOG4105ECP epimerase FPL02_05060 ENOG41067AE Membrane-bound metal-dependent hydrolase FPL02_05065 ENOG4105CEN a g-specific adenine glycosylase FPL02_05070 ENOG4106BXE FPL02_05090 ENOG4105BZ1 (ABC) transporter FPL02_05095 ENOG4107NBY Membrane FPL02_05100 ENOG4105CBC glutamate synthase FPL02_05110 ENOG4108IUW ABC transporter FPL02_05130 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL02_05135 ENOG4105G5W regulator Fur family FPL02_05235 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL02_05320 ENOG4108JQC penicillin-binding protein 1A FPL02_05325 ENOG4107ZQN disulfide bond FPL02_05335 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FPL02_05345 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FPL02_05355 ENOG4105CYN Serine protein kinase FPL02_05395 ENOG4105DZ6 Band 7 protein FPL02_05405 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FPL02_05410 ENOG4108V9W transcriptional regulatory protein FPL02_05415 ENOG4105D4T Citrate transporter FPL02_05440 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FPL02_05450 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component FPL02_05455 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FPL02_05460 ENOG4105BZ7 extracellular solute-binding protein family 1 FPL02_05465 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) FPL02_05470 ENOG4108STX response regulator FPL02_05475 ENOG4105US7 Histidine kinase FPL02_05495 ENOG4108UZ3 Transporter FPL02_05500 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL02_05510 ENOG4105BZU Histidine kinase FPL02_05515 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_05520 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FPL02_05525 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FPL02_05530 ENOG4108JB9 formate dehydrogenase FPL02_05550 ENOG4105CUB amino acid FPL02_05570 ENOG4105DAP Nicotinate phosphoribosyltransferase FPL02_05605 ENOG41073R8 VanW family FPL02_05610 ENOG4108KGH TRANSCRIPTIONal FPL02_05615 ENOG4105D9N nucleoside FPL02_05620 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FPL02_05625 ENOG4105C37 (CBS) domain FPL02_05630 ENOG4108IJ0 Aspartate ammonia-lyase FPL02_05635 ENOG4105DAA L-lactate FPL02_05650 ENOG4105DUX Transporter FPL02_05655 ENOG4108MES Periplasmic binding protein FPL02_05660 ENOG4105DQ5 transport system permease protein FPL02_05665 ENOG4108IHU transport system permease protein FPL02_05670 ENOG4105E0A ABC, transporter FPL02_05675 ENOG4105DMQ Methyltransferase FPL02_05685 ENOG4105EXW epimerase dehydratase FPL02_05690 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FPL02_05700 ENOG4107T89 von Willebrand factor, type A FPL02_05705 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FPL02_05710 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL02_05725 ENOG4105BZU Histidine kinase FPL02_05730 ENOG4105D5Q Arginine ornithine antiporter FPL02_05735 ENOG4107414 GntR family transcriptional regulator FPL02_05740 ENOG4105C5Y PTS System FPL02_05745 ENOG4105CG3 alpha amylase, catalytic region FPL02_05760 ENOG4105E1K spore germination protein FPL02_05770 ENOG4105CRN Aminoglycoside phosphotransferase FPL02_05775 ENOG4105BZG amino acid carrier protein FPL02_05780 ENOG4105CDA abc transporter atp-binding protein FPL02_05785 ENOG4105CT1 (ABC) transporter FPL02_05790 ENOG4105EAD ABC transporter FPL02_05795 ENOG4105DRP amino acid AbC transporter FPL02_05800 ENOG4108IQI permease FPL02_05825 ENOG4105D29 Helix-turn-helix type 11 domain protein FPL02_05830 ENOG4105NAE bifunctional deaminase-reductase domain protein FPL02_05835 ENOG4105BZU Histidine kinase FPL02_05850 ENOG4105CHH sulfate transporter FPL02_05855 ENOG41068KF Universal stress protein FPL02_05875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FPL02_05880 ENOG4108JQ7 (ABC) transporter FPL02_05890 ENOG4105CXY transporter FPL02_05895 ENOG41067TZ transcriptional regulator, MarR family FPL02_05900 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_05905 ENOG4105ETE Transcriptional regulator (LacI family FPL02_05910 ENOG4108RVA ribokinase FPL02_05920 ENOG4105C2J ABC transporter FPL02_05930 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FPL02_05935 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FPL02_05975 ENOG4105D7V transposase FPL02_06010 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FPL02_06015 ENOG41069ER domain protein FPL02_06020 ENOG4105VZ8 Transcriptional regulator FPL02_06025 ENOG4107D63 FPL02_06040 ENOG4105DUX Transporter FPL02_06050 ENOG4105D01 (LipO)protein FPL02_06055 ENOG4105FDT acyl-CoA dehydrogenase FPL02_06060 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FPL02_06065 ENOG4108UMI ABC transporter, permease FPL02_06080 ENOG4105C85 amino acid FPL02_06085 ENOG4105C7N Xanthine uracil vitamin C permease FPL02_06100 ENOG4105MA6 gCN5-related N-acetyltransferase FPL02_06125 ENOG4105BZ9 Cytochrome C oxidase, subunit I FPL02_06130 ENOG4105E2S oxidase) subunit II FPL02_06150 ENOG4106CAD Protein of unknown function (DUF3311) FPL02_06155 ENOG4105E1V na solute symporter FPL02_06185 ENOG4105CE1 Ferrous iron transport protein b FPL02_06190 ENOG4105CVA phosphate FPL02_06195 ENOG4105C8U phosphate abc transporter FPL02_06200 ENOG4105E2Z phosphate ABC transporter (Permease FPL02_06335 ENOG41080XQ Signal transduction protein with cbs domains FPL02_06355 ENOG4105ETU transcriptional activator (TenA FPL02_06365 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FPL02_06375 ENOG4108VEU Thiamine monophosphate synthase FPL02_06380 ENOG41080HI glycine oxidase FPL02_06395 ENOG4105D06 uba thif-type nad fad binding protein FPL02_06400 ENOG4105DWF phosphomethylpyrimidine kinase FPL02_06450 ENOG4108INS Transcriptional regulator FPL02_06475 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL02_06485 ENOG4105C7N Xanthine uracil vitamin C permease FPL02_06495 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FPL02_06510 ENOG4105K63 Thioredoxin FPL02_06530 ENOG4108B31 Spore germination protein FPL02_06550 ENOG4107Y03 Nitroreductase FPL02_06555 ENOG4105ED1 spovr family FPL02_06575 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FPL02_06580 ENOG4105XTG Pfam:DUF156 FPL02_06585 ENOG4105VFE sira family FPL02_06590 ENOG4107TPS domain protein FPL02_06595 ENOG4105VFE sira family FPL02_06600 ENOG4105VFE sira family FPL02_06610 ENOG41085GJ domain protein FPL02_06620 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FPL02_06625 ENOG41087NI Sulfite exporter TauE/SafE FPL02_06635 ENOG4108KGH TRANSCRIPTIONal FPL02_06665 ENOG4105EMD TRANSCRIPTIONal FPL02_06670 ENOG4105VCP PTS System FPL02_06675 ENOG4105VZJ PTS System FPL02_06710 ENOG4107RBB ABC transporter, permease FPL02_06715 ENOG4105C19 ABC transporter FPL02_06780 ENOG4107T5V SNARE associated Golgi FPL02_06815 ENOG4107RWR Sodium hydrogen exchanger FPL02_06825 ENOG4106KNT transcriptional regulator FPL02_06865 ENOG4108YXU transcriptional regulator AsnC family FPL02_06885 ENOG4105KPY Small multidrug resistance protein FPL02_06890 ENOG4105KPY Small multidrug resistance protein FPL02_06915 ENOG4105NF4 modulator of drug activity FPL02_06930 ENOG4105E5W Transporter FPL02_06945 ENOG4105CH6 catalase FPL02_06955 ENOG4105D5Q Arginine ornithine antiporter FPL02_06960 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FPL02_06970 ENOG4105C26 Dehydrogenase FPL02_06985 ENOG4105BZ1 (ABC) transporter FPL02_06990 ENOG4105BZ1 (ABC) transporter FPL02_07005 ENOG4105DRP amino acid AbC transporter FPL02_07010 ENOG4105CDA abc transporter atp-binding protein FPL02_07025 ENOG410839P FPL02_07055 ENOG4105WH1 Two component transcriptional regulator luxr family FPL02_07100 ENOG4107FQX Alpha-acetolactate decarboxylase FPL02_07115 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FPL02_07120 ENOG4105D4P Coproporphyrinogen iii oxidase FPL02_07135 ENOG4105CHH sulfate transporter FPL02_07170 ENOG4106AKK s-layer domain-containing protein FPL02_07185 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL02_07200 ENOG4105CGU Enoyl-CoA hydratase FPL02_07220 ENOG4105DER m42 family FPL02_07265 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL02_07275 ENOG4108JQ7 (ABC) transporter FPL02_07285 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FPL02_07325 ENOG4105CSH Transporter FPL02_07335 ENOG4108MRH transcriptional regulatory protein FPL02_07385 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FPL02_07395 ENOG4105C4R Atp-dependent dna helicase FPL02_07445 ENOG4105CDU Replicative dna helicase FPL02_07460 ENOG4105CDU Replicative dna helicase FPL02_07490 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_07595 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL02_07625 ENOG4105CMT Dihydroxyacetone kinase FPL02_07640 ENOG4105CMT Dihydroxyacetone kinase FPL02_07670 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase FPL02_07755 ENOG4105WN5 stage II sporulation protein FPL02_07765 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_07775 ENOG4108MJI response regulator FPL02_07780 ENOG4105BZU Histidine kinase FPL02_07785 ENOG4105BZU Histidine kinase FPL02_07805 ENOG4105K8R UPF0145 protein FPL02_07845 ENOG4107VRP DNA repair exonuclease FPL02_07885 ENOG4108MUZ hydrolase FPL02_07900 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FPL02_07915 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FPL02_07925 ENOG4105EMN RNA polymerase sigma factor FPL02_07935 ENOG4105CNI cell division protein FtsW FPL02_07950 ENOG4105C57 major facilitator superfamily FPL02_07955 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_07965 ENOG4105EEM helicase FPL02_08010 ENOG4106BHF FPL02_08030 ENOG4105CFG Acts as a chaperone (By similarity) FPL02_08035 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FPL02_08040 ENOG4106F1P AAA ATPase, central domain protein FPL02_08045 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL02_08070 ENOG4105K59 histidine triad (HIT) protein FPL02_08165 ENOG410905X membrane-flanked domain protein FPL02_08200 ENOG410905X membrane-flanked domain protein FPL02_08205 ENOG4105CKV Membrane FPL02_08210 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FPL02_08225 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FPL02_08230 ENOG4105C1Q protoporphyrinogen oxidase FPL02_08260 ENOG4105ECB domain protein FPL02_08285 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FPL02_08295 ENOG4105D29 Helix-turn-helix type 11 domain protein FPL02_08305 ENOG4106AXD FPL02_08310 ENOG4108RQ5 Beta-lactamase domain-containing protein FPL02_08315 ENOG4105DF9 Lipoate-protein, ligase FPL02_08325 ENOG4105CEY Amp-dependent synthetase and ligase FPL02_08455 ENOG4105ENX hydrolase FPL02_08465 ENOG4107TVP HD domain protein FPL02_08470 ENOG4107YPT transcriptional regulator FPL02_08475 ENOG4105C57 major facilitator superfamily FPL02_08485 ENOG4108AEY RNA polymerase sigma factor FPL02_08495 ENOG41086D8 Transcriptional regulator FPL02_08510 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL02_08535 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FPL02_08555 ENOG4105ZU5 s-layer protein FPL02_08560 ENOG4107QP3 malate synthase g FPL02_08580 ENOG4105VEQ Cold shock protein FPL02_08595 ENOG4105XVF Competence transcription factor FPL02_08690 ENOG4105CAQ asparagine synthetase FPL02_08700 ENOG4105CH6 catalase FPL02_08705 ENOG4105BZU Histidine kinase FPL02_08730 ENOG4105QNR S1 RNA binding domain protein FPL02_08745 ENOG4107AYK membrAne FPL02_08750 ENOG41073B9 FPL02_08760 ENOG4108KP7 hydrolase FPL02_08770 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FPL02_08795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FPL02_08815 ENOG4105C31 Tryptophanyl-tRNA synthetase FPL02_08835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FPL02_08840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FPL02_08850 ENOG4108JQ7 (ABC) transporter FPL02_08855 ENOG4105UQX Mate efflux family protein FPL02_08875 ENOG4108ZCF integral membrane protein FPL02_08885 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL02_08895 ENOG4105DPN Oligoendopeptidase f FPL02_08905 ENOG4108Z18 K06886 hemoglobin FPL02_08910 ENOG4105MIX Adenylate cyclase FPL02_08915 ENOG4106EFP UPF0738 protein FPL02_08930 ENOG4105EMS pseudouridine synthase FPL02_08950 ENOG4105K64 Glycosyl transferase, family 2 FPL02_08970 ENOG4107TVC Glycosyl transferase, family 2 FPL02_08990 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FPL02_08995 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FPL02_09005 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FPL02_09080 ENOG4105CK7 Sodium proline symporter FPL02_09095 ENOG4105DDQ anthranilate synthase FPL02_09195 ENOG4105C7S Dehydrogenase FPL02_09205 ENOG4105VZ8 Transcriptional regulator FPL02_09245 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FPL02_09255 ENOG4105DZ1 carboxypeptidase FPL02_09260 ENOG4105VFR signal peptidase FPL02_09295 ENOG4105C26 Dehydrogenase FPL02_09305 ENOG4105F38 ABC transporter, permease FPL02_09310 ENOG4105D38 putrescine abc transporter FPL02_09315 ENOG4107RUE extracellular solute-binding protein family 1 FPL02_09325 ENOG4105EYF MMPL domain protein FPL02_09335 ENOG4108YBP pseudouridine synthase FPL02_09345 ENOG4105K4I Scp-like extracellular FPL02_09350 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FPL02_09355 ENOG4105CQB FAD linked oxidase domain protein FPL02_09370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_09375 ENOG4105BZU Histidine kinase FPL02_09380 ENOG4105JXH GntR family transcriptional regulator FPL02_09400 ENOG4106A3R peptidase FPL02_09410 ENOG4108QTI )-transporter FPL02_09415 ENOG4107TS3 membrane protein, TerC FPL02_09420 ENOG4105CZN Potassium uptake protein FPL02_09425 ENOG410681C small acid-soluble spore protein FPL02_09430 ENOG4108Z7G MaoC domain protein dehydratase FPL02_09450 ENOG4105CHR reductase FPL02_09480 ENOG4105C4Y ABC transporter FPL02_09485 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FPL02_09490 ENOG4107RCV ABC transporter, permease FPL02_09510 ENOG4105E98 transcriptional regulator DeoR family FPL02_09520 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FPL02_09540 ENOG4105BZU Histidine kinase FPL02_09545 ENOG41090MY MarR family Transcriptional regulator FPL02_09555 ENOG4106DF1 FPL02_09565 ENOG4105BZU Histidine kinase FPL02_09575 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FPL02_09580 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FPL02_09625 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FPL02_09640 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FPL02_09645 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FPL02_09660 ENOG4105CJ1 ABC, transporter FPL02_09700 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FPL02_09705 ENOG4105EA8 2-Nitropropane dioxygenase FPL02_09710 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FPL02_09720 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FPL02_09740 ENOG4105NQC Flavodoxin FPL02_09800 ENOG4105CZN Potassium uptake protein FPL02_09810 ENOG4105KBJ sporulation protein ytfj FPL02_09835 ENOG4105CM2 brancheD-chain amino acid aminotransferase FPL02_09840 ENOG4105C7K acetolactate synthase FPL02_09845 ENOG4108ZP8 Acetolactate synthase small subunit FPL02_09920 ENOG4107RVV histidinol phosphate phosphatase, hisj family FPL02_09935 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase FPL02_09940 ENOG4105E0M Sulfatase FPL02_09950 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FPL02_09970 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) FPL02_09975 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) FPL02_09985 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FPL02_09990 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FPL02_10000 ENOG4105C8J )-transporter FPL02_10020 ENOG4105DFD Na H antiporter FPL02_10045 ENOG4105WH1 Two component transcriptional regulator luxr family FPL02_10065 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FPL02_10110 ENOG4105CJ3 phosphate transporter FPL02_10115 ENOG4107GRR phosphate transport regulator FPL02_10120 ENOG4105BZ4 penicillin-binding protein FPL02_10145 ENOG4105BZU Histidine kinase FPL02_10150 ENOG4105I3N Conserved Protein FPL02_10165 ENOG4105BZU Histidine kinase FPL02_10195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL02_10200 ENOG4105DZ1 carboxypeptidase FPL02_10205 ENOG4108JIC nucleoside recognition domain protein FPL02_10215 ENOG4105FE9 pseudouridine synthase FPL02_10225 ENOG4107TWT Cytochrome c biogenesis protein FPL02_10230 ENOG4105CRE cytochrome C FPL02_10235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_10240 ENOG4105BZU Histidine kinase FPL02_10245 ENOG4108WBT adenosyltransferase FPL02_10270 ENOG4108SAX Membrane FPL02_10290 ENOG4105I7S Abortive infection protein FPL02_10300 ENOG4107RGJ metallophosphoesterase FPL02_10305 ENOG4107X2D transcriptional regulator, merr family FPL02_10310 ENOG4108S6Z Negative regulator of genetic competence FPL02_10335 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FPL02_10340 ENOG4105HDK L-asparaginase FPL02_10370 ENOG4105S2F FPL02_10375 ENOG41065D1 FPL02_10405 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FPL02_10420 ENOG4105XXQ heptaprenyl diphosphate synthase component I FPL02_10430 ENOG4105EAH synthase FPL02_10450 ENOG4105CIH Imidazole acetol-phosphate transaminase FPL02_10455 ENOG41068YB TPR repeat-containing protein FPL02_10470 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) FPL02_10475 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FPL02_10510 ENOG4108JYZ YitT family FPL02_10520 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FPL02_10535 ENOG4105FJR Lmbe family FPL02_10540 ENOG4105CPK Glycosyl transferase (Group 1 FPL02_10575 ENOG4105DVT helicase FPL02_10580 ENOG4105YAC FPL02_10600 ENOG4105CSM endonuclease III FPL02_10610 ENOG4105BZ4 penicillin-binding protein FPL02_10665 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FPL02_10675 ENOG4105DVT helicase FPL02_10680 ENOG4105CTD carboxy-peptidase FPL02_10690 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FPL02_10700 ENOG4105C2W permease FPL02_10705 ENOG4105DHF Membrane FPL02_10720 ENOG4108W0I acetyltransferase FPL02_10730 ENOG4105KHC sulfurtransferase FPL02_10755 ENOG4106032 Glutathionylspermidine synthase FPL02_10785 ENOG4108SZE gCN5-related N-acetyltransferase FPL02_10870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL02_10880 ENOG4107RWR Sodium hydrogen exchanger FPL02_10885 ENOG4105CN5 Metallo-Beta-Lactamase FPL02_10890 ENOG4108Z5V transcriptional regulator, merr family FPL02_10900 ENOG4105H67 Protein of unknown function (DUF421) FPL02_10905 ENOG41080C8 DUF218 domain FPL02_10935 ENOG4107Y80 Major Facilitator superfamily FPL02_10965 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FPL02_10975 ENOG4107R0U MotA TolQ exbB proton channel FPL02_10980 ENOG4105ER2 Ompa motb domain protein FPL02_10985 ENOG4107YTP response regulator receiver protein FPL02_10990 ENOG4105CBS Chea signal transduction histidine kinase FPL02_10995 ENOG4105DD5 Flagellar motor switch protein FPL02_11010 ENOG4105BZU Histidine kinase FPL02_11035 ENOG4105DTJ flagellar hook-associated protein FPL02_11040 ENOG4107TPX flagellar hook-associated FPL02_11055 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FPL02_11060 ENOG4108ZC9 flagellar basal-body rod protein flgc FPL02_11065 ENOG41075Z6 flagellar hook-basal body complex protein fliE FPL02_11070 ENOG4107U2N Flagellar M-ring protein FPL02_11075 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FPL02_11120 ENOG4107R88 Chemotaxis protein (CheV) FPL02_11130 ENOG4105I03 Flagellin FPL02_11140 ENOG4105E4C Lytic transglycosylase catalytic FPL02_11150 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FPL02_11155 ENOG4105DD5 Flagellar motor switch protein FPL02_11165 ENOG4105CN7 Flagellar biosynthetic protein FliP FPL02_11170 ENOG4105VS8 Flagellar biosynthetic protein fliq FPL02_11185 ENOG4105D7B Flagellar biosynthesis protein flha FPL02_11190 ENOG4105FZW flagellar biosynthesis regulator FlhF FPL02_11220 ENOG4108RZE Tetr family transcriptional regulator FPL02_11240 ENOG4105KAC Antibiotic biosynthesis monooxygenase FPL02_11265 ENOG4105DUM transcriptional regulator, lysR family FPL02_11270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FPL02_11280 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component FPL02_11285 ENOG4105CN5 Metallo-Beta-Lactamase FPL02_11325 ENOG4105CVJ phosphoglycerate mutase FPL02_11335 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) FPL02_11355 ENOG4105CAQ asparagine synthetase FPL02_11375 ENOG4105PGM cation diffusion facilitator family transporter FPL02_11385 ENOG4105DRR Transcriptional regulator, GntR family FPL02_11390 ENOG4108UZ3 Transporter FPL02_11400 ENOG4105DFD Na H antiporter FPL02_11405 ENOG4105VUF Transcriptional regulator FPL02_11410 ENOG4105EMU Dehydrogenase FPL02_11415 ENOG4105C9Q fumarate hydratase class II FPL02_11430 ENOG4107QJQ Mate efflux family protein FPL02_11435 ENOG4105EC3 peptidase S51, dipeptidase E FPL02_11480 ENOG4106BRA Membrane FPL02_11520 ENOG4105CJ1 ABC, transporter FPL02_11540 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) FPL02_11550 ENOG4108IJ0 Aspartate ammonia-lyase FPL02_11555 ENOG4105C6K Malic enzyme FPL02_11675 ENOG4105CSR polyphosphate kinase 2 FPL02_11685 ENOG4105DXI Major Facilitator superfamily FPL02_11700 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FPL02_11710 ENOG4105EU0 Major facilitator Superfamily FPL02_11715 ENOG4105C6T cysteine synthase FPL02_11735 ENOG4105C8J )-transporter FPL02_11745 ENOG4105X5K response regulator receiver protein FPL02_11750 ENOG4105H67 Protein of unknown function (DUF421) FPL02_11760 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FPL02_11765 ENOG4105CM2 brancheD-chain amino acid aminotransferase FPL02_11775 ENOG4108ZP8 Acetolactate synthase small subunit FPL02_11780 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FPL02_11790 ENOG4105C7B Threonine dehydratase FPL02_11815 ENOG4105C6X Major Facilitator FPL02_11830 ENOG4105DY9 regulatoR FPL02_11835 ENOG4105CYC Transferase FPL02_11900 ENOG41068WN FPL02_11905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL02_11925 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FPL02_11930 ENOG4105C72 UPF0176 protein FPL02_11940 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FPL02_11945 ENOG4105C0X amino acid FPL02_11970 ENOG4107RHR regulatoR FPL02_11980 ENOG4105D9N nucleoside FPL02_11985 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FPL02_12005 ENOG4107RAQ aminopeptidase FPL02_12060 ENOG4108T5E Copper resistance protein FPL02_12065 ENOG4105KTB nuclear export factor GLE1 FPL02_12075 ENOG4107RT3 EamA-like transporter family FPL02_12080 ENOG4105GZI Transcriptional regulator FPL02_12085 ENOG4108Z40 Transcriptional regulator FPL02_12090 ENOG4107ZXU DSBA oxidoreductase FPL02_12095 ENOG4108TVJ Nitroreductase FPL02_12105 ENOG4106F5Q Membrane FPL02_12115 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FPL02_12125 ENOG4105CKI cobalamin synthesis protein FPL02_12140 ENOG4108Z7G MaoC domain protein dehydratase FPL02_12145 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FPL02_12160 ENOG4108IV0 ABC, transporter FPL02_12165 ENOG4105C32 Amino acid ABC transporter (Permease) FPL02_12175 ENOG4105SKE transcriptional Regulator LysR family FPL02_12185 ENOG4105MDS 4-oxalocrotonate tautomerase FPL02_12205 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL02_12210 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL02_12215 ENOG4108JJ9 ABC, transporter FPL02_12220 ENOG4108JJ8 (ABC) transporter FPL02_12240 ENOG4108UT6 Transferase hexapeptide repeat containing protein FPL02_12295 ENOG4105BZ1 (ABC) transporter FPL02_12300 ENOG4105EFI regulatoR FPL02_12305 ENOG4105BZU Histidine kinase FPL02_12325 ENOG4108ZJ4 polysaccharide deacetylase FPL02_12345 ENOG4105D6E homoserine dehydrogenase FPL02_12370 ENOG4108KGH TRANSCRIPTIONal FPL02_12380 ENOG4107VMI polysaccharide deacetylase FPL02_12390 ENOG4105KT7 mgtC SapB transporter FPL02_12395 ENOG4105VRR gCN5-related N-acetyltransferase FPL02_12400 ENOG4105YWU small acid-soluble spore protein FPL02_12410 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FPL02_12460 ENOG4105KRN Transcriptional regulator, abrb family FPL02_12480 ENOG4108KB1 transcriptional regulator, arac family FPL02_12485 ENOG4108JP0 extracellular solute-binding protein family 1 FPL02_12495 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FPL02_12500 ENOG4105CT8 Phosphorylase FPL02_12505 ENOG4105DKQ ROK family FPL02_12520 ENOG4105DE4 1-phosphofructokinase FPL02_12525 ENOG4105D2M Aldolase FPL02_12535 ENOG4105ESP cell wall surface anchor family protein FPL02_12540 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase FPL02_12545 ENOG4105YVS arsR family transcriptional regulator FPL02_12550 ENOG4105CPC Aldo Keto reductase FPL02_12585 ENOG4105C8Q Methyl-accepting chemotaxis FPL02_12600 ENOG4108K88 Membrane FPL02_12605 ENOG4108K88 Membrane FPL02_12610 ENOG4108WPJ Ferritin-like domain FPL02_12625 ENOG4105DEN Luciferase family FPL02_12640 ENOG4105VMI -acetyltransferase FPL02_12645 ENOG4107QM2 Aldo Keto reductase FPL02_12650 ENOG4105CKI cobalamin synthesis protein FPL02_12670 ENOG4108IBT Inherit from COG: transposase FPL02_12675 ENOG4105DSE periplasmic solute binding protein FPL02_12680 ENOG4105K4T epimerase FPL02_12690 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FPL02_12715 ENOG4105CVJ phosphoglycerate mutase FPL02_12735 ENOG4107T5V SNARE associated Golgi FPL02_12750 ENOG4108PJD permease FPL02_12760 ENOG4108S4H thioesterase Superfamily protein FPL02_12770 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FPL02_12790 ENOG4105SXS Protein of unknown function (DUF456) FPL02_12795 ENOG4105C37 (CBS) domain FPL02_12815 ENOG4108Z7R Chaperone CsaA FPL02_12835 ENOG4108ZRV stage ii sporulation protein p FPL02_12845 ENOG4108VXD carboxy-peptidase FPL02_12855 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FPL02_12895 ENOG4108X4Q Hydrolase FPL02_12905 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FPL02_12925 ENOG41087PP glycosyltransferase MGT family FPL02_12930 ENOG4108JYZ YitT family FPL02_12935 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FPL02_12965 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) FPL02_13015 ENOG4105KBJ sporulation protein ytfj FPL02_13040 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FPL02_13060 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FPL02_13065 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily FPL02_13075 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FPL02_13080 ENOG4105EMN RNA polymerase sigma factor FPL02_13095 ENOG4105CNW domain protein FPL02_13105 ENOG4108V06 Glutathione peroxidase FPL02_13120 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL02_13130 ENOG4108IUE nitrate reductase beta subunit FPL02_13135 ENOG4105R3A Nitrate reductase FPL02_13150 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FPL02_13160 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL02_13165 ENOG4108ZAF Molybdopterin FPL02_13195 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FPL02_13200 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FPL02_13205 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FPL02_13210 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FPL02_13215 ENOG4108IFG nitrite reductase, (NAD(P)H) FPL02_13220 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) FPL02_13255 ENOG4105MCT stage V sporulation protein S FPL02_13280 ENOG4105C5H ABC transporter FPL02_13295 ENOG4108UUM single-stranded DNA-binding protein FPL02_13325 ENOG4107YX5 Pfam:DUF548 FPL02_13375 ENOG4105C5S asparaginyl-tRNA synthetase FPL02_13395 ENOG4105EC2 ftsk spoIIIe FPL02_13470 ENOG4105BZW Glycerate kinase FPL02_13475 ENOG4107QPK )-transporter FPL02_13480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_13495 ENOG4106849 propeptide, pepSY amd peptidase M4 FPL02_13520 ENOG4107XGZ Hydrolase FPL02_13525 ENOG4105CY2 Citrate transporter FPL02_13530 ENOG4105C0A alcohol dehydrogenase FPL02_13550 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FPL02_13575 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 FPL02_13595 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) FPL02_13615 ENOG4107RVG penicillin-binding protein FPL02_13620 ENOG4107XM6 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FPL02_13625 ENOG4105E9Q Acyl-transferase FPL02_13630 ENOG4108UT2 hemolysin iii FPL02_13640 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FPL02_13650 ENOG4108RCR degv family FPL02_13655 ENOG4105E8R UPF0173 metal-dependent hydrolase FPL02_13660 ENOG4108KF3 Electron transport protein SCO1 SenC FPL02_13670 ENOG4105CAQ asparagine synthetase FPL02_13695 ENOG4105F0I Aminotransferase FPL02_13720 ENOG4107Y70 Heat shock protein FPL02_13725 ENOG4105D8X mechanosensitive ion channel FPL02_13730 ENOG4105BZU Histidine kinase FPL02_13735 ENOG4105WH1 Two component transcriptional regulator luxr family FPL02_13780 ENOG4108YV3 Protein of unknown function (DUF2711) FPL02_13810 ENOG4108IJ8 ABC transporter FPL02_13815 ENOG4105E90 ABC transporter FPL02_13850 ENOG4105C37 (CBS) domain FPL02_13875 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL02_13890 ENOG4107S4Y M20 DapE family protein YgeY FPL02_13895 ENOG4108TSC N-acetyltransferase FPL02_13905 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FPL02_13945 ENOG4108N23 SpoOM-related protein FPL02_13950 ENOG410841Q phosphoesterase PA-phosphatase related protein FPL02_13960 ENOG4105SZ6 Thioredoxin FPL02_13970 ENOG4108TFU terminase (Small subunit) FPL02_14005 ENOG4108AEY RNA polymerase sigma factor FPL02_14035 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL02_14070 ENOG4105BZ4 penicillin-binding protein FPL02_14080 ENOG4105CZM Major Facilitator FPL02_14085 ENOG4105W8X HesB YadR YfhF-family protein FPL02_14095 ENOG4105DXD 2-methylcitrate dehydratase FPL02_14100 ENOG4105CR4 methylisocitrate lyase FPL02_14105 ENOG4105C1G acyl-Coa dehydrogenase FPL02_14110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL02_14120 ENOG4105N14 lysine exporter protein LysE YggA FPL02_14125 ENOG4105E39 Enoyl-CoA hydratase FPL02_14140 ENOG4107RFY SbcCD D subunit FPL02_14165 ENOG4105FCD Major Facilitator FPL02_14170 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FPL02_14175 ENOG4105E4F Isochorismate synthase FPL02_14180 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FPL02_14185 ENOG4105WQI isochorismatase FPL02_14190 ENOG4105CEY Amp-dependent synthetase and ligase FPL02_14195 ENOG4105WQT MbtH domain protein FPL02_14200 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_14215 ENOG4105K70 DNA-binding protein FPL02_14255 ENOG4105FE9 pseudouridine synthase FPL02_14260 ENOG4105C22 threonyL-tRNA synthetase FPL02_14265 ENOG4105C19 ABC transporter FPL02_14305 ENOG4108D32 Methyltransferase FPL02_14330 ENOG41081I9 integral membrane protein FPL02_14345 ENOG4105C5X domain protein FPL02_14355 ENOG4105EYF MMPL domain protein FPL02_14375 ENOG4105WCN acetyltransferase FPL02_14400 ENOG4105C1Q protoporphyrinogen oxidase FPL02_14410 ENOG41068WN FPL02_14420 ENOG4105VEQ Cold shock protein FPL02_14445 ENOG410667J hydrolase FPL02_14465 ENOG4107V2S Transcriptional regulator FPL02_14470 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FPL02_14485 ENOG4105DND Transcriptional regulator FPL02_14490 ENOG4108RPX mosc domain containing protein FPL02_14505 ENOG4105BZ1 (ABC) transporter FPL02_14510 ENOG4105BZ1 (ABC) transporter FPL02_14525 ENOG4108JCI Transcriptional regulator FPL02_14570 ENOG4108KPJ rna polymerase sigma factor FPL02_14590 ENOG4105F32 YngK protein FPL02_14615 ENOG4105RD7 BadF BadG BcrA BcrD FPL02_14625 ENOG4107STF Involved in phosphonate degradation (By similarity) FPL02_14630 ENOG4105C7B Threonine dehydratase FPL02_14650 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FPL02_14665 ENOG4105C1J atp-dependent rna helicase FPL02_14685 ENOG4108RZE Tetr family transcriptional regulator FPL02_14720 ENOG4108I0C methyltransferase FPL02_14725 ENOG4107RA9 decarboxylase FPL02_14765 ENOG4105CIN aminoacyl-histidine dipeptidase FPL02_14795 ENOG4107RF6 penicillin-binding protein FPL02_14810 ENOG4105DIN metallophosphoesterase FPL02_14820 ENOG4105CJ1 ABC, transporter FPL02_14830 ENOG4107Z3H Transcriptional regulator, TetR family FPL02_14845 ENOG4105C1G acyl-Coa dehydrogenase FPL02_14855 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FPL02_14860 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FPL02_14865 ENOG4105E39 Enoyl-CoA hydratase FPL02_14870 ENOG4107QX3 carboxylase FPL02_14875 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FPL02_14895 ENOG4105WCN acetyltransferase FPL02_14900 ENOG4105DBI uridine monophosphokinase FPL02_14930 ENOG4105T9C HD domain FPL02_14940 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FPL02_14985 ENOG4107Y80 Major Facilitator superfamily FPL02_15000 ENOG41089UC methyltransferase, type 11 FPL02_15015 ENOG4105CUV Homoserine Kinase FPL02_15050 ENOG410900G Protein of unknown function (DUF421) FPL02_15055 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) FPL02_15075 ENOG4105DK7 lysyl-tRNA synthetase FPL02_15140 ENOG4105D6E homoserine dehydrogenase FPL02_15155 ENOG4105ETU transcriptional activator (TenA FPL02_15165 ENOG4108TFU terminase (Small subunit) FPL02_15170 ENOG4108TFU terminase (Small subunit) FPL02_15285 ENOG4105BZU Histidine kinase FPL02_15325 ENOG4108HGU Histidine kinase FPL02_15335 ENOG4105RHY Pfam:UPF0157 FPL02_15345 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FPL02_15355 ENOG4108IG5 Transcriptional regulator FPL02_15360 ENOG4105CHR reductase FPL02_15440 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FPL02_15465 ENOG4107Y9U Membrane FPL02_15475 ENOG4105EGD dinuclear metal center protein, YbgI family FPL02_15515 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FPL02_15520 ENOG4108Z4K mutator MutT protein FPL02_15550 ENOG4108XI2 Domain of unknown function (DUF1963) FPL02_15570 ENOG4108NRW Phospholipase, patatin family FPL02_15575 ENOG4105KWG Pfam:DUF1696 FPL02_15610 ENOG4105PKS Excinuclease abc c subunit domain protein FPL02_15645 ENOG4107VFR oxidoreductase FPL02_15670 ENOG4105U0R haloacid dehalogenase-like hydrolase FPL02_15690 ENOG4108IUM Glycogen debranching enzyme FPL02_15770 ENOG4105MSI germination protein ypeb FPL02_15805 ENOG4107Z3H Transcriptional regulator, TetR family FPL02_15840 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FPL02_15855 ENOG4105E98 transcriptional regulator DeoR family FPL02_15875 ENOG4107QKR Dehydrogenase FPL02_15885 ENOG4107RUY (E1 component), alpha subunit FPL02_15895 ENOG4105E1F short-chain dehydrogenase reductase FPL02_15900 ENOG4105RHY Pfam:UPF0157 FPL02_15905 ENOG4105DBI uridine monophosphokinase FPL02_15915 ENOG4108TIT dATP pyrophosphohydrolase FPL02_15970 ENOG4105E66 phosphoriboisomerase A FPL02_15975 ENOG41082BV acetyltransferase FPL02_15985 ENOG41087PP glycosyltransferase MGT family FPL02_16010 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL02_16015 ENOG4105MSB protein, conserved in bacteria FPL02_16025 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FPL02_16090 ENOG4105C9U ATP-dependent DNA helicase RecQ FPL02_16140 ENOG4108M1A Chitin-binding protein FPL02_16160 ENOG4105BZG amino acid carrier protein FPL02_16165 ENOG4105C26 Dehydrogenase FPL02_16170 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL02_16175 ENOG4105CTU Proline racemase FPL02_16180 ENOG4105CTU Proline racemase FPL02_16185 ENOG41080HI glycine oxidase FPL02_16195 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein FPL02_16235 ENOG4105DCI Phosphohydrolase FPL02_16240 ENOG4107T5V SNARE associated Golgi FPL02_16255 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FPL02_16260 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FPL02_16320 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) FPL02_16325 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FPL02_16330 ENOG4105BZU Histidine kinase FPL02_16355 ENOG4107S75 HAD-superfamily hydrolase subfamily IA variant 3 FPL02_16375 ENOG4105DPN Oligoendopeptidase f FPL02_16400 ENOG4105EPR degv family FPL02_16460 ENOG4106K7D Major facilitator family transporter FPL02_16480 ENOG4107BMA Transglycosylase associated protein FPL02_16495 ENOG41089UC methyltransferase, type 11 FPL02_16555 ENOG4105DVE abc transporter atp-binding protein FPL02_16600 ENOG4105C02 permease FPL02_16610 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) FPL02_16615 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FPL02_16620 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FPL02_16665 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FPL02_16715 ENOG4107VC0 DNA alkylation repair enzyme FPL02_16720 ENOG4107VMI polysaccharide deacetylase FPL02_16725 ENOG4108ZCF integral membrane protein FPL02_16730 ENOG4105E0M Sulfatase FPL02_16740 ENOG4105C5H ABC transporter FPL02_16755 ENOG4105EYF MMPL domain protein FPL02_16760 ENOG41082JN Transcriptional regulator FPL02_16780 ENOG4105CIH Imidazole acetol-phosphate transaminase FPL02_16790 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FPL02_16845 ENOG4105MKU Transcriptional regulator FPL02_16860 ENOG4105D4B ABC, transporter FPL02_16870 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FPL02_16880 ENOG4105DKT Transcriptional regulator FPL02_16885 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FPL02_16895 ENOG41061GT Aldolase FPL02_16910 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) FPL02_16940 ENOG4105II7 pyrroline-5-carboxylate reductase FPL02_16950 ENOG4107258 Transcriptional regulator FPL02_16965 ENOG4105E0Y RtcB Protein FPL02_16970 ENOG4105ECK Fatty Acid Desaturase FPL02_17005 ENOG41090T1 Membrane FPL02_17015 ENOG4108WCX response regulator FPL02_17025 ENOG4105KNA -acetyltransferase FPL02_17050 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL02_17070 ENOG4105C8Y Acetylornithine aminotransferase FPL02_17130 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FPL02_17140 ENOG4108TVJ Nitroreductase FPL02_17145 ENOG4105FS7 Transcriptional regulator FPL02_17165 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FPL02_17170 ENOG4105WEC Molybdate metabolism regulator FPL02_17180 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FPL02_17205 ENOG4108DMH HTH_ARAC FPL02_17210 ENOG4108XET gCN5-related N-acetyltransferase FPL02_17225 ENOG4108PCN EamA-like transporter family FPL02_17275 ENOG410635A Membrane FPL02_17280 ENOG4105KNA -acetyltransferase FPL02_17285 ENOG4108IQI permease FPL02_17295 ENOG4105F1N DNA alkylation repair FPL02_17335 ENOG4107RF6 penicillin-binding protein FPL02_17380 ENOG4107258 Transcriptional regulator FPL02_17390 ENOG4106N3A copper homeostasis protein cutc FPL02_17395 ENOG4108ZRV stage ii sporulation protein p FPL02_17400 ENOG4108ZHR arsR family transcriptional regulator FPL02_17410 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_17420 ENOG4105FDT acyl-CoA dehydrogenase FPL02_17435 ENOG4105DWD nucleoside recognition domain protein FPL02_17455 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FPL02_17530 ENOG4107RA9 decarboxylase FPL02_17545 ENOG4107QJQ Mate efflux family protein FPL02_17555 ENOG4107QTZ amino acid FPL02_17560 ENOG4105CGH 5'-nucleotidase FPL02_17565 ENOG4105CH6 catalase FPL02_17620 ENOG4108606 TspO/MBR family FPL02_17625 ENOG4105CVP deoxyribo-dipyrimidine photolyase FPL02_17640 ENOG4108TWJ NADH dehydrogenase subunit 5 FPL02_17645 ENOG4105GPN Uncharacterized conserved protein (DUF2294) FPL02_17660 ENOG4105E1K spore germination protein FPL02_17675 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FPL02_17690 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FPL02_17700 ENOG4105C19 ABC transporter FPL02_17715 ENOG4108NEV two component transcriptional regulator, LytTR family FPL02_17740 ENOG4105Z7P Acetyltransferase (GNAT) family FPL02_17760 ENOG4105DET Rhamnulokinase FPL02_17765 ENOG4107W7X Aldolase FPL02_17775 ENOG4105CNN ABC, transporter FPL02_17785 ENOG4105NWF RbsD or FucU transport FPL02_17790 ENOG4105ETE Transcriptional regulator (LacI family FPL02_17810 ENOG4105D6J arsenicaL-resistance protein FPL02_17815 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase FPL02_17820 ENOG41085FC arsR family transcriptional regulator FPL02_17830 ENOG4105NAE bifunctional deaminase-reductase domain protein FPL02_17850 ENOG4105EKQ RNA-directed DNA polymerase FPL02_17870 ENOG4107V2S Transcriptional regulator FPL02_17880 ENOG4107P5I polyketide synthase FPL02_17885 ENOG4108IG5 Transcriptional regulator FPL02_17890 ENOG4105CHR reductase FPL02_17895 ENOG4108YXU transcriptional regulator AsnC family FPL02_17975 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FPL02_17980 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_18000 ENOG4105IIP Membrane FPL02_18045 ENOG4105K6H D-cysteine desulfhydrase FPL02_18065 ENOG4105JQZ Methyltransferase FPL02_18085 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) FPL02_18105 ENOG4105BZU Histidine kinase FPL02_18115 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FPL02_18120 ENOG4105DJB Major Facilitator Superfamily FPL02_18125 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FPL02_18130 ENOG4107QR9 Iron-sulfur cluster binding protein FPL02_18160 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FPL02_18195 ENOG41082W1 Cupin 2, conserved barrel domain protein FPL02_18205 ENOG410874W AraC family transcriptional regulator FPL02_18225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FPL02_18255 ENOG4108ISG Major Facilitator FPL02_18270 ENOG4107MII Sugar-specific transcriptional regulator TrmB FPL02_18275 ENOG4105CZM Major Facilitator FPL02_18290 ENOG4105DA5 (ABC) transporter FPL02_18295 ENOG41069JR FPL02_18305 ENOG4105RXJ FPL02_18310 ENOG4105KPY Small multidrug resistance protein FPL02_18330 ENOG4105CRW Short chain fatty acid transporter FPL02_18340 ENOG4105DYS nad(p)h dehydrogenase (quinone) FPL02_18375 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FPL02_18415 ENOG4107TXC Transcriptional regulator FPL02_18450 ENOG4108Z66 YbaK ebsC protein FPL02_18470 ENOG4105KVH Transcriptional regulator FPL02_18495 ENOG4108PSK reductase FPL02_18505 ENOG4105CJ1 ABC, transporter FPL02_18565 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase FPL02_18570 ENOG4105DKQ ROK family FPL02_18580 ENOG4108UW5 maltose o-acetyltransferase FPL02_18585 ENOG4105C31 Tryptophanyl-tRNA synthetase FPL02_18620 ENOG4105DMQ Methyltransferase FPL02_18630 ENOG4105EV4 Multidrug resistance protein mdtH FPL02_18655 ENOG4105C37 (CBS) domain FPL02_18670 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FPL02_18675 ENOG4105FAW cDP-glucose 4,6-dehydratase FPL02_18715 ENOG4105DDN Pentapeptide repeat-containing protein FPL02_18720 ENOG4105XDF Protein of unknown function (DUF1272) FPL02_18725 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FPL02_18730 ENOG4105CMG Carbohydrate kinase FPL02_18735 ENOG4105C6Z Gluconate FPL02_18740 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FPL02_18755 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FPL02_18760 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FPL02_18765 ENOG4105CIS alcohol dehydrogenase FPL02_18770 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone FPL02_18800 ENOG4105CV8 reductase FPL02_18805 ENOG4105F27 Major Facilitator FPL02_18820 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FPL02_18825 ENOG4105C44 Serine transporter FPL02_18855 ENOG4105KVH Transcriptional regulator FPL02_18860 ENOG4108TZY GntR Family Transcriptional Regulator FPL02_18865 ENOG4105D9R oxidoreductase FPL02_18875 ENOG4105KVH Transcriptional regulator FPL02_18880 ENOG4105KVH Transcriptional regulator FPL02_18925 ENOG4105JAB phenazine biosynthesis protein, phzf family FPL02_18935 ENOG4105CHR reductase FPL02_18945 ENOG4105KNA -acetyltransferase FPL02_18955 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein FPL02_18960 ENOG4105KVH Transcriptional regulator FPL02_18975 ENOG4108ZJ4 polysaccharide deacetylase FPL02_19055 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) FPL02_19075 ENOG410751J FPL02_19095 ENOG4105H3G oxidoreductase FPL02_19140 ENOG4105K7K Transcriptional regulator FPL02_19145 ENOG4105CIS alcohol dehydrogenase FPL02_19190 ENOG4108TN2 lmbE family FPL02_19200 ENOG4107R3E Citrate transporter FPL02_19210 ENOG4108MES Periplasmic binding protein FPL02_19215 ENOG4105EHG Permease protein FPL02_19220 ENOG4105DQ5 transport system permease protein FPL02_19225 ENOG4105NX3 Membrane FPL02_19245 ENOG4107CUJ Protein of unknown function (DUF2690) FPL02_19255 ENOG4107V2S Transcriptional regulator FPL02_19280 ENOG4105C98 muts2 protein FPL02_19285 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FPL02_19290 ENOG4105DPN Oligoendopeptidase f FPL02_19295 ENOG4108A04 Beta-lactamase FPL02_19325 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FPL02_19345 ENOG41082BM Transcriptional regulator, arsr family FPL02_19350 ENOG4105CIS alcohol dehydrogenase FPL02_19360 ENOG4107JM4 Tetratricopeptide repeat FPL02_19375 ENOG4105RHY Pfam:UPF0157 FPL02_19385 ENOG4105C09 Bile acid FPL02_19390 ENOG4105CQB FAD linked oxidase domain protein FPL02_19425 ENOG4105KT7 mgtC SapB transporter FPL02_19440 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FPL02_19445 ENOG41073R8 VanW family FPL02_19455 ENOG4108R1P FPL02_19475 ENOG4105VEQ Cold shock protein FPL02_19495 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) FPL02_19515 ENOG410904N short-chain dehydrogenase reductase FPL02_19525 ENOG4106IQC argininosuccinate lyase FPL02_19540 ENOG4108IA2 Sodium pantothenate symporter FPL02_19550 ENOG4105C26 Dehydrogenase FPL02_19555 ENOG4105CHR reductase FPL02_19580 ENOG410696E Membrane FPL02_19595 ENOG4105D1F ATP-binding protein FPL02_19605 ENOG4108ZAF Molybdopterin FPL02_19610 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL02_19620 ENOG4105TMB Formate nitrite transporter FPL02_19630 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FPL02_19635 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) FPL02_19645 ENOG4108JB9 formate dehydrogenase FPL02_19650 ENOG4105E1K spore germination protein FPL02_19720 ENOG4107QJT sodium dicarboxylate symporter FPL02_19725 ENOG4108KGH TRANSCRIPTIONal FPL02_19735 ENOG4105EMN RNA polymerase sigma factor FPL02_19750 ENOG4105CIG ABC transporter FPL02_19760 ENOG4105D9R oxidoreductase FPL02_19770 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FPL02_19775 ENOG4105K4P CoA-binding domain protein FPL02_19780 ENOG4105C0H protease FPL02_19785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_19795 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FPL02_19805 ENOG4105W8X HesB YadR YfhF-family protein FPL02_19835 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FPL02_19845 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FPL02_19855 ENOG4105BZ1 (ABC) transporter FPL02_19860 ENOG4108I0Z Aconitate hydratase FPL02_19890 ENOG4105E5W Transporter FPL02_19900 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FPL02_19925 ENOG4107ZYJ bioY protein FPL02_19930 ENOG4105CEY Amp-dependent synthetase and ligase FPL02_19945 ENOG4108IMY Transcriptional regulator FPL02_20000 ENOG4107AYK membrAne FPL02_20015 ENOG4105BZU Histidine kinase FPL02_20020 ENOG4105FBA Phospholipase Carboxylesterase FPL02_20025 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FPL02_20030 ENOG4105CK7 Sodium proline symporter FPL02_20040 ENOG4105CBC glutamate synthase FPL02_20045 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FPL02_20050 ENOG4108VJ1 Transcriptional regulator (CarD family FPL02_20055 ENOG4108903 Formimidoylglutamase FPL02_20080 ENOG4107UA9 Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity) FPL02_20130 ENOG4107QIV Cytochrome c biogenesis protein FPL02_20145 ENOG4105CH2 amidohydrolase FPL02_20155 ENOG4105CJ1 ABC, transporter FPL02_20165 ENOG4107RSM transcriptional regulator FPL02_20175 ENOG41067MG lrgb family FPL02_20200 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FPL02_20215 ENOG4105BZ1 (ABC) transporter FPL02_20250 ENOG4105D5T phosphonate abc transporter FPL02_20255 ENOG4108HW3 (ABC) transporter FPL02_20260 ENOG4105CGH 5'-nucleotidase FPL02_20270 ENOG4108SVB resolvase FPL02_20290 ENOG4105K7K Transcriptional regulator FPL02_20295 ENOG4105C5F glutamine synthetase FPL02_20300 ENOG4105KV4 Transcriptional regulator FPL02_20305 ENOG4105CXI aluminum resistance protein FPL02_20310 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FPL02_20315 ENOG4105EN6 Membrane FPL02_20320 ENOG4106F1P AAA ATPase, central domain protein FPL02_20365 ENOG41069ER domain protein FPL02_20370 ENOG4105DM4 PTS System FPL02_20375 ENOG4105DE4 1-phosphofructokinase FPL02_20380 ENOG4105E98 transcriptional regulator DeoR family FPL02_20390 ENOG4108SJC Membrane FPL02_20400 ENOG4105C85 amino acid FPL02_20425 ENOG4105TMB Formate nitrite transporter FPL02_20430 ENOG4105K70 DNA-binding protein FPL02_20440 ENOG4105C59 p-type ATPase FPL02_20445 ENOG410681U heavy metal transport detoxification protein FPL02_20450 ENOG4105VPX protein, conserved in bacteria FPL02_20460 ENOG4105PGM cation diffusion facilitator family transporter FPL02_20480 ENOG4105NIV Esterase FPL02_20485 ENOG4105E0A ABC, transporter FPL02_20515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FPL02_20520 ENOG4105D03 DNA-3-methyladenine glycosylase II FPL02_20550 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FPL02_20575 ENOG4105C5E polysaccharide biosynthesis protein FPL02_20590 ENOG4107ZY0 Phenazine biosynthesis-like protein FPL02_20600 ENOG41067MG lrgb family FPL02_20635 ENOG4105F0V Cell wall hydrolase FPL02_20650 ENOG4105E0M Sulfatase FPL02_20655 ENOG410890F Dynamin family FPL02_20665 ENOG4107QHE Choloylglycine hydrolase FPL02_20745 ENOG4105DQU oxidoreductase, subunit beta FPL02_20750 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein FPL02_20755 ENOG4108IGT Dipeptidase FPL02_20760 ENOG4105MCT stage V sporulation protein S FPL02_20765 ENOG4105D48 metallophosphoesterase FPL02_20770 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FPL02_20790 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FPL02_20805 ENOG4105XZV Protein of unknown function (DUF3243) FPL02_20810 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FPL02_20830 ENOG4105UIB (ABC) transporter FPL02_20835 ENOG4108JQ9 ABC transporter FPL02_20840 ENOG4105DIH basic membrane FPL02_20845 ENOG4105FDP GntR family transcriptional regulator FPL02_20855 ENOG4107QZI cell division protein FtsK FPL02_20865 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FPL02_20875 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FPL02_20890 ENOG4108S0H Dipicolinic acid synthetase, b subunit FPL02_20895 ENOG4105E35 Dipicolinate synthase subunit A FPL02_20905 ENOG4105C1V Peptidase, M16 FPL02_20925 ENOG4105DTN riboflavin biosynthesis protein ribF FPL02_20940 ENOG4105W7A Protein of unknown function (DUF503) FPL02_20950 ENOG4105VHM ribosomal protein FPL02_20955 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FPL02_20960 ENOG4105CHV Transcription elongation factor NusA FPL02_20970 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FPL02_20980 ENOG4105DZP Membrane-associated zinc metalloprotease FPL02_20990 ENOG4105KNE Phosphatidate cytidylyltransferase FPL02_21035 ENOG4108HE4 integrase family FPL02_21045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FPL02_21050 ENOG4105C79 DNA protecting protein DprA FPL02_21070 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FPL02_21095 ENOG4105VB6 UPF0109 protein FPL02_21115 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FPL02_21120 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FPL02_21140 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FPL02_21155 ENOG4105CB5 ATP-dependent DNA helicase recG FPL02_21160 ENOG4105DP4 dak2 domain fusion protein ylov FPL02_21165 ENOG4108ZAA Alkaline-shock protein FPL02_21180 ENOG4105FJ0 thiamine FPL02_21185 ENOG4105DJV ribulose-phosphate 3-epimerase FPL02_21195 ENOG4105D9P serine threonine protein kinase FPL02_21200 ENOG4108ZF3 Phosphatase FPL02_21210 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FPL02_21220 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL02_21225 ENOG4105C25 Primosomal protein n' FPL02_21230 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FPL02_21250 ENOG4105DSJ YicC domain protein FPL02_21260 ENOG4105F23 Fibronectin-binding protein FPL02_21350 ENOG4105C34 Pseudouridine synthase FPL02_21375 ENOG4105DBK s4 domain protein FPL02_21380 ENOG41067XK integral membrane protein FPL02_21390 ENOG4105DFA alanine racemase domain protein FPL02_21395 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FPL02_21400 ENOG4105WR5 sporulation protein, YlmC YmxH family FPL02_21410 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_21420 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FPL02_21425 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FPL02_21430 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FPL02_21445 ENOG4105CNI cell division protein FtsW FPL02_21460 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FPL02_21510 ENOG4105KNH Nucleic acid-binding protein FPL02_21520 ENOG41063PX domain protein FPL02_21525 ENOG4105D78 K07001 NTE family protein FPL02_21530 ENOG4105H20 Sporulation integral membrane protein YlbJ FPL02_21540 ENOG4106H78 methyltransferase FPL02_21560 ENOG4107TB6 phosphoglycerate mutase FPL02_21575 ENOG4106UY4 Inherit from COG: Scp-like extracellular FPL02_21590 ENOG4105EKQ RNA-directed DNA polymerase FPL02_21635 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FPL02_21645 ENOG4105CNI cell division protein FtsW FPL02_21660 ENOG4108IAB Phoh family FPL02_21680 ENOG4105QA2 FPL02_21685 ENOG4105CI3 gtp-binding protein typa FPL02_21695 ENOG4105ECY inositol monophosphatase FPL02_21715 ENOG4105CXN decarboxylase FPL02_21765 ENOG4105CPP Dehydrogenase, E1 component FPL02_21780 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FPL02_21785 ENOG4108X4Q Hydrolase FPL02_21800 ENOG4105CN5 Metallo-Beta-Lactamase FPL02_21805 ENOG4107ZYR domain protein FPL02_21840 ENOG4108XRC Protein of unknown function (DUF458) FPL02_21845 ENOG4107IN1 Protein of unknown function (DUF1797) FPL02_21865 ENOG4105EPM Diguanylate phosphodiesterase FPL02_21870 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FPL02_21885 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FPL02_21895 ENOG4105UIN FPL02_21950 ENOG4108HGU Histidine kinase FPL02_21960 ENOG4105CHM Aminotransferase FPL02_21965 ENOG4105FKQ transcriptional regulator FPL02_21970 ENOG4105EG2 ABC transporter, permease FPL02_21980 ENOG4107FKK extracellular solute-binding protein family 1 FPL02_21990 ENOG4105CG3 alpha amylase, catalytic region FPL02_22035 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FPL02_22040 ENOG4105CHU acetyl-coa acetyltransferase FPL02_22075 ENOG4105K7K Transcriptional regulator FPL02_22080 ENOG4105DTD Dehydrogenase FPL02_22100 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FPL02_22140 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FPL02_22170 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FPL02_22185 ENOG4105CID antiterminator FPL02_22195 ENOG4105FDP GntR family transcriptional regulator FPL02_22205 ENOG4105CE4 GlcNAc 6-P deacetylase FPL02_22250 ENOG4107ZE5 PPIases accelerate the folding of proteins FPL02_22255 ENOG4105PTM secreted protein FPL02_22260 ENOG4105J7I hydrolase FPL02_22270 ENOG4105G6R Stage v sporulation protein ae FPL02_22280 ENOG4105CZ3 stage V sporulation protein ad FPL02_22285 ENOG41090VF Stage v sporulation protein ac FPL02_22305 ENOG4105C8J )-transporter FPL02_22310 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_22320 ENOG41082AN stage II sporulation protein FPL02_22325 ENOG4105DZ1 carboxypeptidase FPL02_22335 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FPL02_22340 ENOG4105DVE abc transporter atp-binding protein FPL02_22375 ENOG4105D7N magnesium and cobalt transport protein CorA FPL02_22400 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FPL02_22410 ENOG4105I3K Ferric uptake regulator, Fur family FPL02_22415 ENOG4105MZ9 stage II sporulation protein m FPL02_22435 ENOG4105CPC Aldo Keto reductase FPL02_22445 ENOG4105RHY Pfam:UPF0157 FPL02_22480 ENOG4108YM7 Gcn5-related n-acetyltransferase FPL02_22500 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FPL02_22505 ENOG4108R6K riboflavin synthase, subunit alpha FPL02_22535 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FPL02_22550 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FPL02_22565 ENOG4105CGH 5'-nucleotidase FPL02_22655 ENOG4108IXY short-chain dehydrogenase reductase FPL02_22660 ENOG41069FQ Metallo-beta-lactamase superfamily FPL02_22665 ENOG4105II7 pyrroline-5-carboxylate reductase FPL02_22670 ENOG4105EJQ L-serine dehydratase FPL02_22695 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FPL02_22715 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FPL02_22730 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FPL02_22735 ENOG4108QEG Membrane FPL02_22740 ENOG4105CDA abc transporter atp-binding protein FPL02_22745 ENOG4105E5Q amino acid AbC transporter FPL02_22750 ENOG4108HW3 (ABC) transporter FPL02_22765 ENOG4108QY0 Membrane FPL02_22780 ENOG4105C7S Dehydrogenase FPL02_22785 ENOG4105CPP Dehydrogenase, E1 component FPL02_22805 ENOG4107RDP Dehydrogenase FPL02_22820 ENOG4108JUB Transcriptional regulator FPL02_22840 ENOG4107QQR Sporulation FPL02_22850 ENOG4105S1Z Stage IV sporulation protein B FPL02_22855 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FPL02_22865 ENOG4105DX0 Hemolysin A FPL02_22900 ENOG4108ZSR alkaline shock protein FPL02_22905 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FPL02_22930 ENOG410644B Stage III sporulation protein af FPL02_22940 ENOG4105KQ4 Stage iii sporulation protein ad FPL02_22945 ENOG4108CQH stage III sporulation protein AC FPL02_22950 ENOG4105KR5 Stage iii sporulation protein FPL02_22955 ENOG4105CD2 stage iii sporulation protein aa FPL02_22980 ENOG4105DC7 peptidase M24 FPL02_22995 ENOG4105CBJ Metal-dependent enzyme FPL02_23005 ENOG4107YBY Hydrolase FPL02_23040 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FPL02_23045 ENOG4105WZW rhodanese family FPL02_23065 ENOG41080TC multidrug resistance protein FPL02_23105 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FPL02_23135 ENOG4105C0D helicase FPL02_23270 ENOG4105C3R Methionine synthase FPL02_23280 ENOG4105C28 cystathionine FPL02_23285 ENOG4105C28 cystathionine FPL02_23305 ENOG4105C5X domain protein FPL02_23315 ENOG4105DKQ ROK family FPL02_23340 ENOG4108UTW Plays a role in the regulation of phosphate uptake FPL02_23345 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FPL02_23350 ENOG4105E2Z phosphate ABC transporter (Permease FPL02_23355 ENOG4105C8U phosphate abc transporter FPL02_23360 ENOG4105PWN phosphate abc transporter FPL02_23365 ENOG4107RF6 penicillin-binding protein FPL02_23375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FPL02_23400 ENOG4105N80 Ferric uptake regulator, Fur family FPL02_23410 ENOG4105FDK ABC transporter FPL02_23415 ENOG4108JYZ YitT family FPL02_23420 ENOG41069ZM Protein of unknown function (DUF2624) FPL02_23445 ENOG4105EGD dinuclear metal center protein, YbgI family FPL02_23460 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_23465 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FPL02_23490 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FPL02_23495 ENOG4105KG3 cytidine deaminase FPL02_23500 ENOG4107YR5 Diacylglycerol kinase FPL02_23515 ENOG4105C9A Phoh family FPL02_23525 ENOG41068P3 sporulation protein YqfC FPL02_23530 ENOG4105KTH gatB Yqey FPL02_23540 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FPL02_23545 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FPL02_23575 ENOG4105CSA Coproporphyrinogen iii oxidase FPL02_23580 ENOG4105KVH Transcriptional regulator FPL02_23615 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FPL02_23620 ENOG4108UK2 deaminase FPL02_23635 ENOG4105DXX methyltransferase FPL02_23645 ENOG4108WF2 Metal Dependent Phosphohydrolase FPL02_23655 ENOG410812S Rna-binding protein FPL02_23665 ENOG4105CQW ribosome biogenesis GTPase YqeH FPL02_23670 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FPL02_23685 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_23705 ENOG4108TVJ Nitroreductase FPL02_23720 ENOG4105G6Z alkaline phosphatase FPL02_23725 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FPL02_23730 ENOG4108MUZ hydrolase FPL02_23770 ENOG4105MIR Phenylalanine 4-monooxygenase FPL02_23780 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FPL02_23820 ENOG4105S6R Iron-hydroxamate transporter permease subunit FPL02_23825 ENOG4108HUF Transporter FPL02_23840 ENOG4108EKI Dehydrogenase FPL02_23845 ENOG4105C28 cystathionine FPL02_23875 ENOG4107XRG penicillin-binding protein FPL02_23890 ENOG4105CFP Peptidase U32 FPL02_23895 ENOG4105XYU peptidase (U32 family) FPL02_23900 ENOG4108VQJ O-methyltransferase FPL02_23905 ENOG4105HHA aminodeoxychorismate lyase FPL02_23935 ENOG4105C02 permease FPL02_23950 ENOG41060CR FPL02_23955 ENOG4105C7H Helicase, RecD TraA family FPL02_23970 ENOG4105C3J Cysteine desulfurase FPL02_23980 ENOG4105D1H recombination factor protein RarA FPL02_23985 ENOG4108VCI transcription factor, rsfa family FPL02_23995 ENOG4105CUZ uba thif-type nad fad binding protein FPL02_24020 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FPL02_24030 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FPL02_24035 ENOG41076HS cation diffusion facilitator family transporter FPL02_24040 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FPL02_24050 ENOG4105CKP Polysaccharide Biosynthesis Protein FPL02_24055 ENOG4108QG2 Membrane FPL02_24065 ENOG4105VIE preprotein translocase, subunit YajC FPL02_24080 ENOG41061AI Protein of unknown function (DUF2905) FPL02_24095 ENOG4108HUF Transporter FPL02_24110 ENOG41082BM Transcriptional regulator, arsr family FPL02_24155 ENOG4108RPX mosc domain containing protein FPL02_24160 ENOG4105CQC Prephenate dehydratase FPL02_24180 ENOG4105EWM Histidine kinase FPL02_24210 ENOG4105C03 ribonuclease FPL02_24225 ENOG4107QMS site-determining protein FPL02_24240 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FPL02_24245 ENOG4105DFF Rod shape-determining protein mreb FPL02_24270 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FPL02_24285 ENOG41068KH stage VI sporulation protein D FPL02_24295 ENOG4105D52 delta-aminolevulinic acid dehydratase FPL02_24320 ENOG4105K56 Transcriptional regulator FPL02_24340 ENOG4108IUQ atp-dependent protease FPL02_24395 ENOG4105M59 Phosphodiesterase, mj0936 family FPL02_24400 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FPL02_24410 ENOG4108XJQ germination protein FPL02_24430 ENOG4105KBX Transcriptional regulator, TetR family FPL02_24440 ENOG4105PFC Transcriptional regulator FPL02_24455 ENOG4105DZC cytosine deaminase FPL02_24460 ENOG4105DZC cytosine deaminase FPL02_24465 ENOG4105DEF Extracellular solute-binding protein, family 5 FPL02_24485 ENOG4108JQ7 (ABC) transporter FPL02_24490 ENOG4108HRK Histidine kinase FPL02_24495 ENOG4105DY9 regulatoR FPL02_24505 ENOG41067S9 phage shock protein C, PspC FPL02_24510 ENOG4108JCI Transcriptional regulator FPL02_24520 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FPL02_24525 ENOG4108Z40 Transcriptional regulator FPL02_24530 ENOG4105RHA ABC transporter, permease FPL02_24535 ENOG4108IUX (ABC) transporter FPL02_24540 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family FPL02_24545 ENOG4105ER2 Ompa motb domain protein FPL02_24550 ENOG4105E14 MotA TolQ exbB proton channel FPL02_24565 ENOG4105E33 succinate dehydrogenase FPL02_24575 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FPL02_24590 ENOG4105K63 Thioredoxin FPL02_24600 ENOG4105BZJ Electron transfer flavoprotein FPL02_24605 ENOG41060WC Enoyl-CoA hydratase FPL02_24610 ENOG4107Z3H Transcriptional regulator, TetR family FPL02_24615 ENOG4105CEY Amp-dependent synthetase and ligase FPL02_24625 ENOG4105S6R Iron-hydroxamate transporter permease subunit FPL02_24675 ENOG4105DR4 Methyltransferase FPL02_24690 ENOG4105KFN sortase, SrtB family FPL02_24695 ENOG4105E0A ABC, transporter FPL02_24710 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FPL02_24715 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FPL02_24725 ENOG4105FE9 pseudouridine synthase FPL02_24735 ENOG4105DCG PHP domain protein FPL02_24785 ENOG4108RWN rrna methyltransferase FPL02_24805 ENOG4105C0R drug resistance transporter emrb qaca subfamily FPL02_24810 ENOG4105CW7 secretion protein, HlyD family FPL02_24820 ENOG4105CN9 Peptidase m42 family protein FPL02_24840 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FPL02_24845 ENOG4105C22 threonyL-tRNA synthetase FPL02_24850 ENOG4108TDW sporulation protein YtxC FPL02_24870 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FPL02_24875 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FPL02_24880 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FPL02_24895 ENOG4105C2M dna polymerase I FPL02_24900 ENOG4105BZU Histidine kinase FPL02_24905 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FPL02_24925 ENOG4108HMX isocitrate dehydrogenase (NADP) FPL02_24930 ENOG4105BZN citrate synthase FPL02_24945 ENOG4108REF Sporulation integral membrane protein ytvi FPL02_24950 ENOG4105FS0 cytoplasmic membrane protein FPL02_24975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family FPL02_24980 ENOG4105C6K Malic enzyme FPL02_24990 ENOG4105VV2 FPL02_25000 ENOG4105SFS phosphoesterase RecJ domain protein FPL02_25040 ENOG4105DC7 peptidase M24 FPL02_25075 ENOG41082W1 Cupin 2, conserved barrel domain protein FPL02_25085 ENOG4105VZ8 Transcriptional regulator FPL02_25105 ENOG4107YZX Universal stress protein FPL02_25150 ENOG4108JYZ YitT family FPL02_25180 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FPL02_25185 ENOG4105KBJ sporulation protein ytfj FPL02_25200 ENOG4105EFZ amidohydrolase FPL02_25210 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FPL02_25245 ENOG4105U5Y Transcriptional regulator FPL02_25255 ENOG4105C28 cystathionine FPL02_25285 ENOG4105EMN RNA polymerase sigma factor FPL02_25305 ENOG4105F1V Acetoin utilization protein FPL02_25310 ENOG4105W87 Cbs domain FPL02_25315 ENOG4105DGU Histone deacetylase FPL02_25340 ENOG4107SNB ankyrin repeat protein YahD FPL02_25345 ENOG4105EP9 oxidoreductase FPL02_25375 ENOG4105ETE Transcriptional regulator (LacI family FPL02_25400 ENOG4105C88 aminopeptidase FPL02_25425 ENOG4108IPJ Membrane FPL02_25435 ENOG4105K7K Transcriptional regulator FPL02_25465 ENOG4108VDD TRNA binding domain protein FPL02_25495 ENOG4105C8F Beta-lactamase domain protein FPL02_25510 ENOG4108V15 phosphotransferase enzyme family FPL02_25515 ENOG4108IUM Glycogen debranching enzyme FPL02_25525 ENOG4107QSE Dipeptidase FPL02_25530 ENOG4105YW5 deoR family transcriptional regulator FPL02_25545 ENOG4105CBX hi0933 family FPL02_25585 ENOG4108VJ1 Transcriptional regulator (CarD family FPL02_25590 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FPL02_25610 ENOG4108ZAF Molybdopterin FPL02_25615 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FPL02_25620 ENOG4105CVM Molybdenum cofactor synthesis domain protein FPL02_25630 ENOG4105D06 uba thif-type nad fad binding protein FPL02_25635 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FPL02_25680 ENOG41085GJ domain protein FPL02_25690 ENOG4105DWV Homoserine O-trans-acetylase FPL02_25700 ENOG4108B31 Spore germination protein FPL02_25730 ENOG410605W Major Facilitator FPL02_25735 ENOG4107S91 Sodium hydrogen exchanger FPL02_25740 ENOG4105NCW Trka-c domain protein FPL02_25755 ENOG4105C19 ABC transporter FPL02_25775 ENOG4105N5T Radical SAM Protein FPL02_25790 ENOG4105CIG ABC transporter FPL02_25840 ENOG4105E8V Alpha Beta Hydrolase Fold protein FPL02_25845 ENOG4108Z0R Transferase FPL02_25850 ENOG4105YVM Phosphoesterase, PA-phosphatase related FPL02_25855 ENOG4105BZF Glycosyl transferase (Group 1 FPL02_25865 ENOG4108RIR Molybdenum cofactor biosynthesis protein FPL02_25915 ENOG4105EGD dinuclear metal center protein, YbgI family FPL02_25925 ENOG4105BZU Histidine kinase FPL02_25930 ENOG4105BZU Histidine kinase FPL02_25935 ENOG4107S9D Alpha beta hydrolase FPL02_25940 ENOG4107T7U Sulfatase FPL02_25960 ENOG4105D2X ABC transporter substrate-binding protein FPL02_25970 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FPL02_26025 ENOG4108V2W Carbonate dehydratase FPL02_26030 ENOG4105C4M (Ubiquinol oxidase) subunit I FPL02_26035 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FPL02_26110 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL02_26160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_26185 ENOG4108UGV hypoxanthine phosphoribosyltransferase FPL02_26190 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FPL02_26210 ENOG4105C19 ABC transporter FPL02_26235 ENOG4107ZTW SNARE associated Golgi FPL02_26260 ENOG4105C19 ABC transporter FPL02_26265 ENOG41086D8 Transcriptional regulator FPL02_26275 ENOG41082BM Transcriptional regulator, arsr family FPL02_26315 ENOG4105C6Z Gluconate FPL02_26320 ENOG4105FDP GntR family transcriptional regulator FPL02_26340 ENOG41069H0 dihydroorotase EC 3.5.2.3 FPL02_26365 ENOG4105DTQ mandelate racemase muconate lactonizing FPL02_26375 ENOG4108IPT Naphthoate synthase FPL02_26380 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FPL02_26390 ENOG4105E4F Isochorismate synthase FPL02_26395 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FPL02_26405 ENOG4105VEQ Cold shock protein FPL02_26450 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FPL02_26550 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FPL02_26585 ENOG4105KT7 mgtC SapB transporter FPL02_26590 ENOG4107PBV potassium channel FPL02_26610 ENOG4105WG9 Conserved Protein FPL02_26620 ENOG4105CHM Aminotransferase FPL02_26625 ENOG4108ZB6 transcriptional regulator AsnC family FPL02_26630 ENOG4105C5I Dehydrogenase FPL02_26635 ENOG4108MUZ hydrolase FPL02_26645 ENOG4105C87 Aminotransferase class I and II FPL02_26655 ENOG4105Y38 Kinase-associated protein B FPL02_26665 ENOG4107R3E Citrate transporter FPL02_26680 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) FPL02_26685 ENOG4105KA0 thioesterase Superfamily protein FPL02_26700 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FPL02_26720 ENOG41069ER domain protein FPL02_26735 ENOG4105CEP NADH dehydrogenase FPL02_26765 ENOG4105EWC Purine nucleoside phosphorylase FPL02_26785 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FPL02_26810 ENOG4108JJA ABC, transporter FPL02_26815 ENOG4105C4B ABC transporter, permease FPL02_26820 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FPL02_26865 ENOG41083MR nifu domain-containing protein FPL02_26880 ENOG4108W5N phosphatidylglycerophosphatase a FPL02_26890 ENOG4105DYS nad(p)h dehydrogenase (quinone) FPL02_26900 ENOG4105D4U had-superfamily hydrolase, subfamily iia FPL02_26915 ENOG4105CBT Fructose-1,6-bisphosphatase FPL02_26935 ENOG4105MMD transcriptional regulator FPL02_26945 ENOG4107TXC Transcriptional regulator FPL02_26950 ENOG41090T1 Membrane FPL02_26975 ENOG4105FAA peptidase M23 FPL02_26985 ENOG4105KZD Domain of unknown function (DUF1805) FPL02_26990 ENOG4107R8B 5'-nucleotidase FPL02_27000 ENOG4105DIW FeS assembly protein SUFB FPL02_27005 ENOG4108UNV SUF system FeS assembly protein, NifU family FPL02_27010 ENOG4105C9B Cysteine desulfurase FPL02_27015 ENOG4105JRK feS assembly protein SufD FPL02_27020 ENOG4105C3K feS assembly ATPase SufC FPL02_27025 ENOG4105D01 (LipO)protein FPL02_27030 ENOG4105D01 (LipO)protein FPL02_27035 ENOG4108UMI ABC transporter, permease FPL02_27065 ENOG41080E8 Transcriptional regulator, Spx MgsR family FPL02_27135 ENOG4108W8B Beta-lactamase domain protein FPL02_27150 ENOG4105CHU acetyl-coa acetyltransferase FPL02_27165 ENOG4105DZ1 carboxypeptidase FPL02_27215 ENOG4105F27 Major Facilitator FPL02_27220 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) FPL02_27230 ENOG4107R7I amino acid FPL02_27250 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FPL02_27260 ENOG4107AYK membrAne FPL02_27295 ENOG4107ZTW SNARE associated Golgi FPL02_27305 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FPL02_27310 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_27315 ENOG4105BZU Histidine kinase FPL02_27340 ENOG4105C8Q Methyl-accepting chemotaxis FPL02_27345 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FPL02_27350 ENOG4105VG1 fes assembly suf system protein FPL02_27355 ENOG4105D4Y metalloprotease FPL02_27380 ENOG4107S91 Sodium hydrogen exchanger FPL02_27385 ENOG4105NCW Trka-c domain protein FPL02_27395 ENOG4108RMU ferritin dps family protein FPL02_27410 ENOG4108URH decarboxylase FPL02_27420 ENOG41090A1 ferritin FPL02_27430 ENOG4105D9N nucleoside FPL02_27435 ENOG4105D9N nucleoside FPL02_27450 ENOG4108RYK Nad-dependent epimerase dehydratase FPL02_27465 ENOG4105CV8 reductase FPL02_27470 ENOG4105F27 Major Facilitator FPL02_27475 ENOG4105KVH Transcriptional regulator FPL02_27490 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FPL02_27505 ENOG4105C8Q Methyl-accepting chemotaxis FPL02_27515 ENOG4105WMR Protein CrcB homolog FPL02_27530 ENOG4108MK9 spermidine N(1)-acetyltransferase FPL02_27540 ENOG4108VY7 phosphate-starvation-inducible protein PsiE FPL02_27560 ENOG4108IPW abc transporter atp-binding protein FPL02_27565 ENOG4105CM4 permease protein FPL02_27595 ENOG4105C19 ABC transporter FPL02_27615 ENOG4107ZTW SNARE associated Golgi FPL02_27625 ENOG4105DHF Membrane FPL02_27635 ENOG4108Z7R Chaperone CsaA FPL02_27680 ENOG4105DZR Type I site-specific deoxyribonuclease FPL02_27695 ENOG4105CVR type I restriction-modification system FPL02_27720 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FPL02_27730 ENOG4105XZU Preprotein translocase, subunit SecG FPL02_27735 ENOG41067MG lrgb family FPL02_27785 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_27790 ENOG4105RHA ABC transporter, permease FPL02_27795 ENOG4108IUX (ABC) transporter FPL02_27820 ENOG4105BZU Histidine kinase FPL02_27825 ENOG4105WH1 Two component transcriptional regulator luxr family FPL02_27885 ENOG41090VF Stage v sporulation protein ac FPL02_27890 ENOG4105CZ3 stage V sporulation protein ad FPL02_27905 ENOG4108QY0 Membrane FPL02_27910 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FPL02_27920 ENOG4105KRI phosphocarrier protein (HPr FPL02_27930 ENOG4105CHW UPF0052 protein FPL02_27940 ENOG4108Z4K mutator MutT protein FPL02_27950 ENOG4105C3M thioredoxin reductase FPL02_27960 ENOG4108S4C acetyltransferase FPL02_27980 ENOG41086DT Membrane protein of unknown function FPL02_27990 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FPL02_28005 ENOG4107TXC Transcriptional regulator FPL02_28035 ENOG4105DUM transcriptional regulator, lysR family FPL02_28045 ENOG4108WS4 fmn reductase FPL02_28060 ENOG4105BZ1 (ABC) transporter FPL02_28070 ENOG4105CN1 protease FPL02_28075 ENOG4105CRP Part of the ABC transporter FtsEX involved in FPL02_28080 ENOG4105CAK Cell division ATP-binding protein ftsE FPL02_28105 ENOG4108RDQ ABC transporter FPL02_28135 ENOG4105MS2 ribosomal subunit Interface protein FPL02_28140 ENOG4105VEQ Cold shock protein FPL02_28145 ENOG41081UC Inherit from COG: Competence protein FPL02_28155 ENOG4105K4H Nlp p60 protein FPL02_28160 ENOG4105KVH Transcriptional regulator FPL02_28170 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FPL02_28175 ENOG4108KGH TRANSCRIPTIONal FPL02_28180 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FPL02_28185 ENOG4105C6Y Udp-glucose 6-dehydrogenase FPL02_28190 ENOG4105ESV Glycosyl transferase, family 4 FPL02_28200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FPL02_28220 ENOG4105F8D glycoside hydrolase family 4 FPL02_28225 ENOG4105VCP PTS System FPL02_28230 ENOG4105CK1 PTS System FPL02_28240 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FPL02_28250 ENOG4105VCP PTS System FPL02_28260 ENOG4105VZJ PTS System FPL02_28280 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase FPL02_28305 ENOG4105ECB domain protein FPL02_28310 ENOG4107RSM transcriptional regulator FPL02_28340 ENOG4105DAA L-lactate FPL02_28350 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) FPL02_28365 ENOG4105E0M Sulfatase FPL02_28390 ENOG4107R8N Glycosyl transferase, family 2 FPL02_28395 ENOG4105C94 Transporter FPL02_28405 ENOG41069ER domain protein FPL02_28420 ENOG4105KBK Zinc finger, swim domain protein FPL02_28425 ENOG4105C0D helicase FPL02_28455 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FPL02_28465 ENOG4107RBB ABC transporter, permease FPL02_28470 ENOG4105C19 ABC transporter FPL02_28480 ENOG4105CXY transporter FPL02_28495 ENOG41062D9 Histidine kinase FPL02_28500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FPL02_28505 ENOG4105CMR udp-glucose 4-epimerase FPL02_28520 ENOG4108KGH TRANSCRIPTIONal FPL02_28530 ENOG4107EF8 Glycosyl transferase (Group 1 FPL02_28540 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FPL02_28555 ENOG4105ER6 polysaccharide biosynthesis protein FPL02_28560 ENOG4105D3Q Sugar transferase FPL02_28565 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FPL02_28570 ENOG4108RB3 Capsular polysaccharide biosynthesis protein FPL02_28575 ENOG4107YJ4 chain length determinant protein FPL02_28580 ENOG4105HTX biosynthesis protein FPL02_28585 ENOG4108QV3 biosynthesis protein FPL02_28600 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FPL02_28610 ENOG4105FRN stage II sporulation protein FPL02_28625 ENOG4105DY9 regulatoR FPL02_28645 ENOG4106778 Protein of unknown function (DUF1146) FPL02_28650 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FPL02_28655 ENOG4105C8S subunit m FPL02_28660 ENOG4105D65 subunit l FPL02_28685 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)