locus-tag	class	description
NHM99_00010	COG0592	DNA-directed DNA polymerase activity
NHM99_00015	COG2501	S4 domain
NHM99_00025	COG0187	DNA topoisomerase II activity
NHM99_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NHM99_00070	COG1686	Belongs to the peptidase S11 family
NHM99_00100	COG1428	Deoxynucleoside kinase
NHM99_00105	COG1428	Deoxynucleoside kinase
NHM99_00110	COG1335	isochorismatase
NHM99_00115	COG0590	tRNA wobble adenosine to inosine editing
NHM99_00125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NHM99_00180	COG1982	Orn Lys Arg decarboxylase major
NHM99_00190	COG0470	DNA polymerase III
NHM99_00195	COG1774	PSP1 C-terminal conserved region
NHM99_00205	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NHM99_00215	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NHM99_00220	COG2002	toxin-antitoxin pair type II binding
NHM99_00225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHM99_00225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHM99_00230	COG0084	hydrolase, TatD family'
NHM99_00235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NHM99_00250	COG4466	Protein conserved in bacteria
NHM99_00265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NHM99_00270	COG0251	oxidation-reduction process
NHM99_00300	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NHM99_00305	COG2002	toxin-antitoxin pair type II binding
NHM99_00310	COG2244	polysaccharide biosynthetic process
NHM99_00315	COG3956	TIGRFAM MazG family protein
NHM99_00320	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NHM99_00340	COG1098	S1 RNA binding domain
NHM99_00355	COG2208	phosphoserine phosphatase activity
NHM99_00365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NHM99_00370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NHM99_00385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NHM99_00390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NHM99_00395	COG0512	Glutamine amidotransferase of anthranilate synthase
NHM99_00400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHM99_00405	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NHM99_00410	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NHM99_00415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NHM99_00420	COG1396	sequence-specific DNA binding
NHM99_00425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHM99_00515	COG3880	PFAM UvrB UvrC protein
NHM99_00525	COG0542	response to heat
NHM99_00530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NHM99_00540	COG4956	integral membrane protein (PIN domain superfamily)
NHM99_00560	COG1045	serine acetyltransferase
NHM99_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHM99_00580	COG3688	RNA-binding protein containing a PIN domain
NHM99_00595	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NHM99_00600	COG0250	Participates in transcription elongation, termination and antitermination
NHM99_00605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NHM99_00625	COG2813	Specifically methylates the guanine in position
NHM99_00640	COG1358	cellular component organization or biogenesis
NHM99_00710	COG0255	Belongs to the universal ribosomal protein uL29 family
NHM99_00770	COG0201	protein transport
NHM99_00780	COG0024	Methionine aminopeptidase
NHM99_00790	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NHM99_00795	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NHM99_00825	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NHM99_00850	COG0860	N-Acetylmuramoyl-L-alanine amidase
NHM99_00855	COG0489	protein tyrosine kinase activity
NHM99_00865	COG2194	sulfuric ester hydrolase activity
NHM99_00870	COG0726	polysaccharide deacetylase
NHM99_00950	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NHM99_00955	COG4856	YbbR-like protein
NHM99_00975	COG0596	Alpha beta hydrolase
NHM99_00995	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NHM99_01030	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_01035	COG2011	ABC-type metal ion transport system permease component
NHM99_01045	COG1464	Belongs to the NlpA lipoprotein family
NHM99_01050	COG0604	alcohol dehydrogenase
NHM99_01060	COG0277	FAD linked oxidase domain protein
NHM99_01065	COG2271	Major facilitator Superfamily
NHM99_01075	COG2814	Major facilitator Superfamily
NHM99_01090	COG0601	transmembrane transport
NHM99_01095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHM99_01100	COG0444	Belongs to the ABC transporter superfamily
NHM99_01105	COG4608	Belongs to the ABC transporter superfamily
NHM99_01110	COG4166	transmembrane transport
NHM99_01125	COG4166	transmembrane transport
NHM99_01130	COG4166	transmembrane transport
NHM99_01135	COG0656	L-ascorbic acid biosynthetic process
NHM99_01155	COG4149	molybdate abc transporter
NHM99_01160	COG0725	ABC transporter, periplasmic molybdate-binding protein
NHM99_01165	COG1910	domain protein
NHM99_01180	COG0697	spore germination
NHM99_01195	COG0204	Acyl-transferase
NHM99_01205	COG1609	Transcriptional regulator
NHM99_01215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_01225	COG0084	hydrolase, TatD family'
NHM99_01230	COG5298	Protein conserved in bacteria
NHM99_01255	COG0488	(ABC) transporter
NHM99_01265	COG0747	negative chemotaxis
NHM99_01270	COG0747	negative chemotaxis
NHM99_01275	COG0601	transmembrane transport
NHM99_01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHM99_01285	COG0444	Belongs to the ABC transporter superfamily
NHM99_01290	COG4608	Belongs to the ABC transporter superfamily
NHM99_01295	COG0561	phosphatase activity
NHM99_01325	COG3185	4-Hydroxyphenylpyruvate dioxygenase
NHM99_01330	COG0179	Fumarylacetoacetate (FAA) hydrolase
NHM99_01340	COG0531	amino acid
NHM99_01345	COG2814	Major facilitator Superfamily
NHM99_01355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NHM99_01365	COG4294	response to UV
NHM99_01370	COG0705	Rhomboid family
NHM99_01380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NHM99_01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHM99_01390	COG0864	Transcriptional regulator
NHM99_01395	COG2337	Toxic component of a toxin-antitoxin (TA) module
NHM99_01400	COG2183	response to ionizing radiation
NHM99_01495	COG0802	atpase or kinase
NHM99_01500	COG1214	PFAM Peptidase M22, glycoprotease
NHM99_01505	COG0456	acetyltransferase
NHM99_01515	COG0488	(ABC) transporter
NHM99_01530	COG1266	CAAX protease self-immunity
NHM99_01550	COG2252	PERMEase
NHM99_01560	COG5002	protein histidine kinase activity
NHM99_01585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NHM99_01615	COG2226	methyltransferase
NHM99_01635	COG1215	transferase activity, transferring glycosyl groups
NHM99_01655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_01660	COG0506	proline dehydrogenase activity
NHM99_01685	COG0697	spore germination
NHM99_01715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NHM99_01720	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NHM99_01725	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NHM99_01750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NHM99_01760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NHM99_01795	COG0210	DNA helicase
NHM99_01805	COG4851	CamS sex pheromone cAM373 precursor
NHM99_01825	COG1335	isochorismatase
NHM99_01835	COG2011	ABC-type metal ion transport system permease component
NHM99_01855	COG0003	Pfam Anion-transporting ATPase
NHM99_01860	COG1846	Transcriptional regulator
NHM99_01865	COG4682	membrane
NHM99_01885	COG1597	lipid kinase activity
NHM99_01890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NHM99_01895	COG0546	phosphoglycolate phosphatase activity
NHM99_01900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NHM99_01910	COG1012	belongs to the aldehyde dehydrogenase family
NHM99_01915	COG2076	Multidrug Resistance protein
NHM99_01920	COG2309	aminopeptidase activity
NHM99_01930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHM99_01940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NHM99_01950	COG0028	Belongs to the TPP enzyme family
NHM99_01960	COG4807	Protein conserved in bacteria
NHM99_01985	COG0673	inositol 2-dehydrogenase activity
NHM99_01990	COG0277	FAD linked oxidase domain protein
NHM99_01995	COG0277	FAD linked oxidase domain protein
NHM99_02005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHM99_02025	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NHM99_02030	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NHM99_02040	COG2814	Major facilitator Superfamily
NHM99_02050	COG4807	Protein conserved in bacteria
NHM99_02075	COG1757	Na H antiporter
NHM99_02080	COG1473	amidohydrolase
NHM99_02095	COG0450	alkyl hydroperoxide reductase
NHM99_02125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_02130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_02135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_02150	COG0166	Belongs to the GPI family
NHM99_02190	COG3541	Predicted nucleotidyltransferase
NHM99_02195	COG2814	Major facilitator Superfamily
NHM99_02200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHM99_02200	COG0723	plastoquinol--plastocyanin reductase activity
NHM99_02225	COG0765	amino acid transport
NHM99_02230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHM99_02240	COG0840	transmembrane signaling receptor activity
NHM99_02245	COG0366	Alpha amylase catalytic
NHM99_02250	COG1263	PTS System
NHM99_02250	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHM99_02250	COG2190	(PTS) system
NHM99_02270	COG1695	Transcriptional regulator
NHM99_02280	COG0577	efflux transmembrane transporter activity
NHM99_02285	COG1136	(ABC) transporter
NHM99_02310	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
NHM99_02340	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
NHM99_02355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHM99_02365	COG1116	anion transmembrane transporter activity
NHM99_02375	COG0488	(ABC) transporter
NHM99_02425	COG2270	Major facilitator Superfamily
NHM99_02455	COG2310	stress, protein
NHM99_02460	COG2310	stress, protein
NHM99_02465	COG2310	stress, protein
NHM99_02470	COG0861	Integral membrane protein TerC family
NHM99_02480	COG3853	Toxic anion resistance protein (TelA)
NHM99_02495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NHM99_02505	COG1295	ribonuclease BN
NHM99_02510	COG2217	Heavy metal translocating P-type atpase
NHM99_02515	COG0697	spore germination
NHM99_02530	COG0681	Belongs to the peptidase S26 family
NHM99_02540	COG0586	Pfam SNARE associated Golgi protein
NHM99_02555	COG3871	stress protein (general stress protein 26)
NHM99_02560	COG0387	Pfam Sodium calcium exchanger
NHM99_02570	COG0535	radical SAM domain protein
NHM99_02590	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NHM99_02610	COG3829	transcription factor binding
NHM99_02620	COG0833	amino acid
NHM99_02625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHM99_02660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHM99_02660	COG1263	PTS System
NHM99_02665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NHM99_02680	COG0463	Glycosyl transferase, family 2
NHM99_02690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NHM99_02690	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NHM99_02705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NHM99_02725	COG0402	S-adenosylhomocysteine deaminase activity
NHM99_02760	COG1988	membrane-bound metal-dependent
NHM99_02790	COG1132	(ABC) transporter
NHM99_02795	COG4129	membrane
NHM99_02800	COG0067	glutamate synthase
NHM99_02800	COG0069	glutamate synthase activity
NHM99_02800	COG0070	glutamate synthase
NHM99_02810	COG4555	ABC transporter
NHM99_02830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NHM99_02835	COG0735	belongs to the Fur family
NHM99_02945	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NHM99_02965	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NHM99_02975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NHM99_02985	COG2766	serine protein kinase
NHM99_03005	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NHM99_03015	COG1585	Membrane protein implicated in regulation of membrane protease activity
NHM99_03020	COG2268	Band 7 protein
NHM99_03030	COG3290	protein histidine kinase activity
NHM99_03035	COG4565	transcriptional regulatory protein
NHM99_03040	COG2851	Citrate transporter
NHM99_03065	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NHM99_03070	COG3842	ATPase activity
NHM99_03075	COG1175	transmembrane transport
NHM99_03080	COG0395	ABC-type sugar transport system, permease component
NHM99_03090	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NHM99_03095	COG0745	RESPONSE REGULATOR receiver
NHM99_03100	COG5002	protein histidine kinase activity
NHM99_03110	COG4990	cell redox homeostasis
NHM99_03120	COG0697	spore germination
NHM99_03125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_03135	COG5002	protein histidine kinase activity
NHM99_03140	COG0745	RESPONSE REGULATOR receiver
NHM99_03145	COG0454	-acetyltransferase
NHM99_03145	COG0456	acetyltransferase
NHM99_03150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NHM99_03155	COG3383	formate dehydrogenase (NAD+) activity
NHM99_03160	COG2427	Protein of unknown function (DUF1641)
NHM99_03175	COG0531	amino acid
NHM99_03180	COG0640	Transcriptional regulator
NHM99_03185	COG2217	Heavy metal translocating P-type atpase
NHM99_03190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NHM99_03205	COG3227	Zinc metalloprotease (Elastase)
NHM99_03225	COG2720	vancomycin resistance protein
NHM99_03230	COG1316	TRANSCRIPTIONal
NHM99_03235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHM99_03240	COG0346	lactoylglutathione lyase activity
NHM99_03245	COG1253	flavin adenine dinucleotide binding
NHM99_03250	COG1027	Aspartate ammonia-lyase
NHM99_03260	COG1620	l-lactate permease
NHM99_03275	COG3104	oligopeptide transport
NHM99_03280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_03290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_03300	COG2226	methyltransferase
NHM99_03305	COG0156	8-amino-7-oxononanoate synthase activity
NHM99_03310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NHM99_03315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NHM99_03325	COG4548	von Willebrand factor, type A
NHM99_03330	COG0714	Associated with various cellular activities
NHM99_03335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHM99_03355	COG0531	amino acid
NHM99_03360	COG2188	Transcriptional regulator
NHM99_03365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHM99_03365	COG1263	PTS System
NHM99_03370	COG0366	Alpha amylase catalytic
NHM99_03385	COG0697	spore germination
NHM99_03390	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NHM99_03395	COG1115	amino acid carrier protein
NHM99_03400	COG1126	abc transporter atp-binding protein
NHM99_03405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHM99_03410	COG0765	amino acid transport
NHM99_03415	COG0765	amino acid transport
NHM99_03420	COG0833	amino acid
NHM99_03435	COG1595	DNA-templated transcription, initiation
NHM99_03445	COG2378	regulation of single-species biofilm formation
NHM99_03450	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NHM99_03455	COG5002	protein histidine kinase activity
NHM99_03470	COG0659	secondary active sulfate transmembrane transporter activity
NHM99_03495	COG0601	transmembrane transport
NHM99_03500	COG4608	Belongs to the ABC transporter superfamily
NHM99_03510	COG2271	Major facilitator Superfamily
NHM99_03515	COG1846	Transcriptional regulator
NHM99_03520	COG0477	Major facilitator Superfamily
NHM99_03525	COG1609	Transcriptional regulator
NHM99_03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHM99_03545	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHM99_03550	COG1879	ABC-type sugar transport system periplasmic component
NHM99_03570	COG1063	alcohol dehydrogenase
NHM99_03585	COG3568	Endonuclease Exonuclease Phosphatase
NHM99_03615	COG0840	transmembrane signaling receptor activity
NHM99_03620	COG3583	domain protein
NHM99_03620	COG3584	3D domain protein
NHM99_03625	COG1476	TRANSCRIPTIONal
NHM99_03645	COG3104	oligopeptide transport
NHM99_03650	COG1114	Component of the transport system for branched-chain amino acids
NHM99_03665	COG1113	amino acid transport
NHM99_03670	COG2252	PERMEase
NHM99_03685	COG2153	protein acetylation
NHM99_03695	COG0475	glutathione-regulated potassium exporter activity
NHM99_03695	COG0569	domain protein
NHM99_03710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NHM99_03715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NHM99_03725	COG4990	cell redox homeostasis
NHM99_03740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHM99_03745	COG0697	spore germination
NHM99_03750	COG0531	amino acid
NHM99_03760	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NHM99_03765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NHM99_03770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NHM99_03770	COG1918	ferrous iron import across plasma membrane
NHM99_03775	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NHM99_03780	COG0573	inorganic phosphate transmembrane transporter activity
NHM99_03785	COG0581	inorganic phosphate transmembrane transporter activity
NHM99_03790	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHM99_03910	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NHM99_03930	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NHM99_03935	COG1116	anion transmembrane transporter activity
NHM99_03940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHM99_03945	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NHM99_03950	COG0352	thiamine-phosphate diphosphorylase activity
NHM99_03955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHM99_03960	COG2104	thiamine diphosphate biosynthetic process
NHM99_03970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NHM99_04015	COG2205	protein histidine kinase activity
NHM99_04020	COG2814	Major facilitator Superfamily
NHM99_04025	COG1846	Transcriptional regulator
NHM99_04050	COG1136	(ABC) transporter
NHM99_04065	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHM99_04070	COG1129	ABC transporter
NHM99_04080	COG2252	PERMEase
NHM99_04085	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_04100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NHM99_04105	COG1621	beta-fructofuranosidase activity
NHM99_04110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHM99_04110	COG1263	PTS System
NHM99_04115	COG1609	Transcriptional regulator
NHM99_04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHM99_04165	COG0778	Nitroreductase
NHM99_04170	COG2719	SpoVR family
NHM99_04175	COG0433	COG0433 Predicted ATPase
NHM99_04195	COG0446	pyridine nucleotide-disulphide oxidoreductase
NHM99_04200	COG1937	Protein conserved in bacteria
NHM99_04205	COG0425	Belongs to the sulfur carrier protein TusA family
NHM99_04205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHM99_04210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_04210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHM99_04215	COG0425	Belongs to the sulfur carrier protein TusA family
NHM99_04220	COG0425	Belongs to the sulfur carrier protein TusA family
NHM99_04225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHM99_04225	COG0425	Belongs to the sulfur carrier protein TusA family
NHM99_04235	COG2210	Belongs to the sulfur carrier protein TusA family
NHM99_04240	COG0730	response to heat
NHM99_04250	COG1316	TRANSCRIPTIONal
NHM99_04255	COG0604	alcohol dehydrogenase
NHM99_04260	COG1283	sodium-dependent phosphate transmembrane transporter activity
NHM99_04265	COG2814	Major facilitator Superfamily
NHM99_04275	COG3711	transcriptional antiterminator
NHM99_04275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHM99_04280	COG1447	Phosphotransferase system cellobiose-specific component IIA
NHM99_04285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NHM99_04310	COG1388	LysM domain
NHM99_04310	COG3584	3D domain protein
NHM99_04315	COG0577	efflux transmembrane transporter activity
NHM99_04320	COG1136	(ABC) transporter
NHM99_04330	COG5522	Integral membrane protein (intg_mem_TP0381)
NHM99_04345	COG1114	Component of the transport system for branched-chain amino acids
NHM99_04350	COG3546	catalase activity
NHM99_04385	COG0586	Pfam SNARE associated Golgi protein
NHM99_04420	COG0531	amino acid
NHM99_04425	COG0475	glutathione-regulated potassium exporter activity
NHM99_04435	COG1737	Transcriptional regulator
NHM99_04445	COG1263	PTS System
NHM99_04445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHM99_04455	COG2259	Doxx family
NHM99_04475	COG1522	sequence-specific DNA binding
NHM99_04490	COG2076	Multidrug Resistance protein
NHM99_04495	COG1309	transcriptional regulator
NHM99_04500	COG2814	Major facilitator Superfamily
NHM99_04505	COG1733	regulation of RNA biosynthetic process
NHM99_04510	COG1846	Transcriptional regulator
NHM99_04515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NHM99_04520	COG0477	Major facilitator Superfamily
NHM99_04525	COG0657	acetylesterase activity
NHM99_04530	COG0657	acetylesterase activity
NHM99_04545	COG2124	cytochrome p450
NHM99_04555	COG1063	alcohol dehydrogenase
NHM99_04565	COG1309	transcriptional regulator
NHM99_04570	COG1683	Conserved Protein
NHM99_04590	COG3344	reverse transcriptase
NHM99_04600	COG1733	regulation of RNA biosynthetic process
NHM99_04610	COG2249	NAD(P)H dehydrogenase (quinone) activity
NHM99_04615	COG4533	DNA binding
NHM99_04620	COG2211	Major facilitator Superfamily
NHM99_04630	COG0693	protein deglycase activity
NHM99_04640	COG0531	amino acid
NHM99_04645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NHM99_04650	COG1012	belongs to the aldehyde dehydrogenase family
NHM99_04655	COG1132	(ABC) transporter
NHM99_04660	COG1132	(ABC) transporter
NHM99_04665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHM99_04670	COG0765	amino acid transport
NHM99_04675	COG1126	abc transporter atp-binding protein
NHM99_04690	COG0189	ligase activity
NHM99_04720	COG0028	Belongs to the TPP enzyme family
NHM99_04725	COG3527	Alpha-acetolactate decarboxylase
NHM99_04740	COG3409	Peptidoglycan-binding domain 1 protein
NHM99_04740	COG5632	N-Acetylmuramoyl-L-alanine amidase
NHM99_04745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NHM99_04760	COG3344	reverse transcriptase
NHM99_04775	COG0659	secondary active sulfate transmembrane transporter activity
NHM99_04790	COG0653	protein targeting
NHM99_04795	COG2244	polysaccharide biosynthetic process
NHM99_04810	COG0860	N-Acetylmuramoyl-L-alanine amidase
NHM99_04815	COG4196	transglutaminase domain protein
NHM99_04830	COG1696	Membrane protein involved in D-alanine export
NHM99_04845	COG1024	Enoyl-CoA hydratase
NHM99_04880	COG1363	Peptidase, m42
NHM99_04935	COG0477	Major facilitator Superfamily
NHM99_04940	COG3290	protein histidine kinase activity
NHM99_04945	COG4565	transcriptional regulatory protein
NHM99_04950	COG3181	Tripartite tricarboxylate transporter family receptor
NHM99_05010	COG0582	viral genome integration into host DNA
NHM99_05025	COG4978	Transcriptional regulator
NHM99_05025	COG0789	Transcriptional regulator
NHM99_05040	COG0305	Participates in initiation and elongation during chromosome replication
NHM99_05065	COG0477	Major facilitator Superfamily
NHM99_05135	COG1183	phosphatidylcholine synthase activity
NHM99_05150	COG2376	Dihydroxyacetone kinase
NHM99_05160	COG2376	Dihydroxyacetone kinase
NHM99_05190	COG2770	Histidine kinase
NHM99_05190	COG3437	response regulator, receiver
NHM99_05280	COG3237	CsbD-like
NHM99_05305	COG1191	sigma factor activity
NHM99_05315	COG2208	phosphoserine phosphatase activity
NHM99_05320	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NHM99_05325	COG0784	Response regulator, receiver
NHM99_05325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHM99_05325	COG2198	Histidine kinase
NHM99_05325	COG2205	protein histidine kinase activity
NHM99_05400	COG0420	3'-5' exonuclease activity
NHM99_05405	COG4717	serine-type aminopeptidase activity
NHM99_05415	COG1309	transcriptional regulator
NHM99_05420	COG2814	Major facilitator Superfamily
NHM99_05425	COG0346	lactoylglutathione lyase activity
NHM99_05430	COG0346	lactoylglutathione lyase activity
NHM99_05440	COG2267	carboxylic ester hydrolase activity
NHM99_05475	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NHM99_05480	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NHM99_05490	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NHM99_05505	COG1595	DNA-templated transcription, initiation
NHM99_05515	COG0772	Belongs to the SEDS family
NHM99_05525	COG3973	AAA domain
NHM99_05530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NHM99_05550	COG4980	gas vesicle protein
NHM99_05555	COG0537	adenosine 5'-monophosphoramidase activity
NHM99_05560	COG1131	(ABC) transporter
NHM99_05565	COG4473	ABC transporter
NHM99_05580	COG1309	transcriptional regulator
NHM99_05590	COG3402	PFAM membrane-flanked domain
NHM99_05595	COG3428	Bacterial PH domain
NHM99_05625	COG3402	PFAM membrane-flanked domain
NHM99_05630	COG3428	Bacterial PH domain
NHM99_05635	COG2329	Antibiotic biosynthesis monooxygenase
NHM99_05640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHM99_05655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NHM99_05685	COG1309	transcriptional regulator
NHM99_05690	COG1511	domain protein
NHM99_05720	COG2378	regulation of single-species biofilm formation
NHM99_05725	COG1609	Transcriptional regulator
NHM99_05735	COG1234	tRNA 3'-trailer cleavage
NHM99_05740	COG0095	Lipoate-protein ligase
NHM99_05750	COG0318	PFAM AMP-dependent synthetase and ligase
NHM99_05830	COG1073	alpha beta
NHM99_05835	COG1408	metallophosphoesterase
NHM99_05845	COG1078	dGTPase activity
NHM99_05855	COG1595	DNA-templated transcription, initiation
NHM99_05860	COG3708	Transcriptional regulator
NHM99_05860	COG2207	Transcriptional regulator
NHM99_05875	COG2205	protein histidine kinase activity
NHM99_05880	COG0745	RESPONSE REGULATOR receiver
NHM99_05905	COG0501	Belongs to the peptidase M48B family
NHM99_05910	COG0697	spore germination
NHM99_05930	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
NHM99_05935	COG2224	Isocitrate lyase
NHM99_05945	COG1278	Cold shock
NHM99_05960	COG4903	ComK protein
NHM99_05970	COG0398	Pfam SNARE associated Golgi protein
NHM99_06030	COG0179	Fumarylacetoacetate (FAA) hydrolase
NHM99_06055	COG0367	asparagine synthase
NHM99_06065	COG0753	catalase activity
NHM99_06070	COG0004	ammonium transporteR
NHM99_06090	COG2996	Protein conserved in bacteria
NHM99_06095	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NHM99_06105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_06120	COG0561	phosphatase activity
NHM99_06140	COG2267	carboxylic ester hydrolase activity
NHM99_06155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHM99_06160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NHM99_06165	COG5504	Zn-dependent protease
NHM99_06175	COG0180	Tryptophanyl-tRNA synthetase
NHM99_06185	COG4166	transmembrane transport
NHM99_06190	COG0601	transmembrane transport
NHM99_06195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NHM99_06200	COG0444	Belongs to the ABC transporter superfamily
NHM99_06205	COG4608	Belongs to the ABC transporter superfamily
NHM99_06215	COG4166	transmembrane transport
NHM99_06230	COG0861	Integral membrane protein TerC family
NHM99_06235	COG4862	establishment of competence for transformation
NHM99_06240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHM99_06250	COG1164	Oligoendopeptidase f
NHM99_06265	COG2346	COG2346, Truncated hemoglobins
NHM99_06270	COG4116	CYTH
NHM99_06280	COG2357	RelA SpoT domain protein
NHM99_06290	COG0564	pseudouridine synthase activity
NHM99_06305	COG0772	Belongs to the SEDS family
NHM99_06310	COG1216	Glycosyl transferase, family 2
NHM99_06310	COG0463	Glycosyl transferase, family 2
NHM99_06330	COG0463	Glycosyl transferase, family 2
NHM99_06330	COG0457	Tetratricopeptide repeat
NHM99_06350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NHM99_06365	COG1091	dTDP-4-dehydrorhamnose reductase activity
NHM99_06410	COG2153	protein acetylation
NHM99_06420	COG2382	esterase
NHM99_06435	COG5492	domain, Protein
NHM99_06440	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHM99_06450	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NHM99_06450	COG0512	Glutamine amidotransferase of anthranilate synthase
NHM99_06485	COG1620	l-lactate permease
NHM99_06490	COG5634	Uncharacterized conserved protein (DUF2278)
NHM99_06495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHM99_06565	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHM99_06575	COG1476	TRANSCRIPTIONal
NHM99_06630	COG1686	Belongs to the peptidase S11 family
NHM99_06635	COG0681	Belongs to the peptidase S26 family
NHM99_06670	COG1012	belongs to the aldehyde dehydrogenase family
NHM99_06680	COG1176	ABC-type spermidine putrescine transport system, permease component I
NHM99_06690	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
NHM99_06700	COG2409	Drug exporters of the RND superfamily
NHM99_06710	COG0564	pseudouridine synthase activity
NHM99_06720	COG2340	Cysteine-rich secretory protein family
NHM99_06725	COG0247	lactate metabolic process
NHM99_06730	COG0277	FAD linked oxidase domain protein
NHM99_06735	COG3835	regulator
NHM99_06745	COG0745	RESPONSE REGULATOR receiver
NHM99_06750	COG5002	protein histidine kinase activity
NHM99_06755	COG2186	Transcriptional regulator
NHM99_06775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NHM99_06785	COG2116	formate transmembrane transporter activity
NHM99_06790	COG0861	Integral membrane protein TerC family
NHM99_06795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHM99_06805	COG2030	dehydratase
NHM99_06825	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_06830	COG3243	poly(R)-hydroxyalkanoic acid synthase
NHM99_06840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHM99_06855	COG1840	ABC-type Fe3 transport system, periplasmic component
NHM99_06885	COG1349	DNA-binding transcription factor activity
NHM99_06895	COG0235	Class ii aldolase
NHM99_06905	COG2861	carbohydrate metabolic process
NHM99_06915	COG3852	Histidine kinase
NHM99_06920	COG1846	Transcriptional regulator
NHM99_06930	COG2318	DinB family
NHM99_06940	COG5002	protein histidine kinase activity
NHM99_06950	COG0720	synthase
NHM99_06965	COG4873	Protein conserved in bacteria
NHM99_06995	COG1780	Probably involved in ribonucleotide reductase function
NHM99_07020	COG1725	Transcriptional regulator
NHM99_07025	COG1131	(ABC) transporter
NHM99_07035	COG1131	(ABC) transporter
NHM99_07040	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NHM99_07045	COG1266	CAAX protease self-immunity
NHM99_07055	COG1522	sequence-specific DNA binding
NHM99_07065	COG1335	isochorismatase
NHM99_07075	COG1619	proteins homologs of microcin C7 resistance protein MccF
NHM99_07080	COG2070	2-Nitropropane dioxygenase
NHM99_07085	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NHM99_07095	COG1696	Membrane protein involved in D-alanine export
NHM99_07115	COG0716	FMN binding
NHM99_07130	COG3173	Aminoglycoside phosphotransferase
NHM99_07150	COG0534	Mate efflux family protein
NHM99_07170	COG1846	Transcriptional regulator
NHM99_07180	COG1301	dicarboxylic acid transport
NHM99_07185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NHM99_07190	COG4709	membrane
NHM99_07195	COG3874	Sporulation protein YtfJ
NHM99_07215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHM99_07225	COG0440	acetolactate synthase activity
NHM99_07300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NHM99_07315	COG1183	phosphatidylcholine synthase activity
NHM99_07320	COG1368	sulfuric ester hydrolase activity
NHM99_07330	COG0019	diaminopimelate decarboxylase activity
NHM99_07350	COG0529	Catalyzes the synthesis of activated sulfate
NHM99_07355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHM99_07375	COG1648	precorrin-2 dehydrogenase activity
NHM99_07380	COG0733	neurotransmitter:sodium symporter activity
NHM99_07405	COG1757	Na H antiporter
NHM99_07420	COG4758	membrane
NHM99_07425	COG4585	Histidine kinase
NHM99_07430	COG2197	response regulator
NHM99_07440	COG1114	Component of the transport system for branched-chain amino acids
NHM99_07450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NHM99_07490	COG0730	response to heat
NHM99_07495	COG0306	phosphate transporter
NHM99_07500	COG1392	Phosphate transport regulator
NHM99_07505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHM99_07520	COG3852	Histidine kinase
NHM99_07525	COG1801	Protein of unknown function DUF72
NHM99_07535	COG0582	viral genome integration into host DNA
NHM99_07540	COG5002	protein histidine kinase activity
NHM99_07555	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NHM99_07555	COG0392	lysyltransferase activity
NHM99_07570	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NHM99_07575	COG1686	Belongs to the peptidase S11 family
NHM99_07580	COG2715	membrane protein required for spore maturation
NHM99_07585	COG0700	Nucleoside recognition
NHM99_07590	COG1187	pseudouridine synthase activity
NHM99_07600	COG1333	cytochrome c biogenesis protein
NHM99_07605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHM99_07610	COG0745	RESPONSE REGULATOR receiver
NHM99_07615	COG5002	protein histidine kinase activity
NHM99_07620	COG2096	Adenosyltransferase
NHM99_07625	COG4942	peptidase
NHM99_07635	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NHM99_07640	COG1141	Ferredoxin
NHM99_07650	COG0514	ATP-dependent DNA helicase (RecQ)
NHM99_07655	COG1266	CAAX protease self-immunity
NHM99_07665	COG1408	metallophosphoesterase
NHM99_07675	COG4862	establishment of competence for transformation
NHM99_07680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NHM99_07700	COG0492	ferredoxin-NADP+ reductase activity
NHM99_07705	COG0252	asparaginase activity
NHM99_07775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NHM99_07790	COG0142	geranyltranstransferase activity
NHM99_07800	COG0142	geranyltranstransferase activity
NHM99_07820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NHM99_07830	COG0457	Tetratricopeptide repeat
NHM99_07850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NHM99_07855	COG2010	Cytochrome c
NHM99_07855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NHM99_07865	COG4347	Protein of unknown function (DUF1405)
NHM99_07880	COG2738	Putative neutral zinc metallopeptidase
NHM99_07890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_07895	COG1694	Mazg nucleotide pyrophosphohydrolase
NHM99_07910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NHM99_07915	COG0438	transferase activity, transferring glycosyl groups
NHM99_07950	COG1199	ATP-dependent helicase activity
NHM99_07950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NHM99_07970	COG3935	DnaD domain protein
NHM99_07975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NHM99_07985	COG4499	WXG100 protein secretion system (Wss), protein YukC
NHM99_07985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHM99_08045	COG0116	Belongs to the methyltransferase superfamily
NHM99_08055	COG1199	ATP-dependent helicase activity
NHM99_08060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NHM99_08070	COG0024	Methionine aminopeptidase
NHM99_08080	COG2233	PERMEase
NHM99_08085	COG2311	Membrane
NHM99_08095	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NHM99_08105	COG0456	acetyltransferase
NHM99_08140	COG0754	glutathionylspermidine amidase activity
NHM99_08155	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHM99_08205	COG0328	RNA-DNA hybrid ribonuclease activity
NHM99_08240	COG3403	YqcI/YcgG family
NHM99_08245	COG1280	lysine exporter protein (LysE YggA)
NHM99_08260	COG3162	membrane
NHM99_08265	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHM99_08270	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHM99_08280	COG0475	glutathione-regulated potassium exporter activity
NHM99_08285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NHM99_08290	COG4978	Transcriptional regulator
NHM99_08290	COG0789	Transcriptional regulator
NHM99_08305	COG2323	membrane
NHM99_08310	COG1434	Gram-negative-bacterium-type cell wall biogenesis
NHM99_08345	COG2814	Major facilitator Superfamily
NHM99_08375	COG1923	regulation of RNA biosynthetic process
NHM99_08385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NHM99_08390	COG1360	Flagellar Motor Protein
NHM99_08395	COG2201	protein-glutamate methylesterase activity
NHM99_08400	COG0643	Histidine kinase
NHM99_08400	COG2198	Histidine kinase
NHM99_08405	COG1776	CheC inhibitor of MCP methylation
NHM99_08405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHM99_08420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NHM99_08440	COG1256	bacterial-type flagellum assembly
NHM99_08445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NHM99_08450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NHM99_08465	COG1815	bacterial-type flagellum-dependent cell motility
NHM99_08470	COG1558	bacterial-type flagellum-dependent cell motility
NHM99_08480	COG1766	The M ring may be actively involved in energy transduction
NHM99_08485	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHM99_08495	COG1157	protein secretion by the type III secretion system
NHM99_08530	COG0835	chemotaxis
NHM99_08530	COG0784	Response regulator, receiver
NHM99_08540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NHM99_08545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NHM99_08550	COG0741	lytic transglycosylase activity
NHM99_08560	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHM99_08565	COG1776	CheC inhibitor of MCP methylation
NHM99_08565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NHM99_08575	COG1338	Plays a role in the flagellum-specific transport system
NHM99_08580	COG1987	bacterial-type flagellum assembly
NHM99_08590	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHM99_08595	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NHM99_08600	COG1419	protein localization to endoplasmic reticulum
NHM99_08605	COG4786	Flagellar basal body rod
NHM99_08610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NHM99_08645	COG2329	Antibiotic biosynthesis monooxygenase
NHM99_08660	COG3764	Sortase (surface protein transpeptidase)
NHM99_08665	COG3764	Sortase (surface protein transpeptidase)
NHM99_08690	COG0583	DNA-binding transcription factor activity
NHM99_08695	COG3842	ATPase activity
NHM99_08700	COG0725	ABC transporter, periplasmic molybdate-binding protein
NHM99_08710	COG1234	tRNA 3'-trailer cleavage
NHM99_08725	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_08750	COG0406	alpha-ribazole phosphatase activity
NHM99_08770	COG1846	Transcriptional regulator
NHM99_08780	COG0367	asparagine synthase
NHM99_08785	COG3344	reverse transcriptase
NHM99_08820	COG1802	Transcriptional regulator
NHM99_08825	COG0697	spore germination
NHM99_08830	COG1216	Glycosyl transferase, family 2
NHM99_08830	COG0438	transferase activity, transferring glycosyl groups
NHM99_08835	COG1757	Na H antiporter
NHM99_08845	COG0114	fumarate hydratase activity
NHM99_08870	COG0534	Mate efflux family protein
NHM99_08875	COG3340	Belongs to the peptidase S51 family
NHM99_08915	COG2733	membrane
NHM99_08950	COG1131	(ABC) transporter
NHM99_08965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHM99_08970	COG0528	UMP kinase activity
NHM99_08980	COG1027	Aspartate ammonia-lyase
NHM99_08985	COG0281	malic enzyme
NHM99_08990	COG4191	Histidine kinase
NHM99_08995	COG0784	Response regulator, receiver
NHM99_09000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHM99_09055	COG0860	N-Acetylmuramoyl-L-alanine amidase
NHM99_09065	COG2814	Major facilitator Superfamily
NHM99_09085	COG1966	Carbon starvation protein
NHM99_09095	COG1695	Transcriptional regulator
NHM99_09105	COG0477	Major facilitator Superfamily
NHM99_09110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHM99_09120	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NHM99_09125	COG4166	transmembrane transport
NHM99_09130	COG2223	nitrite transmembrane transporter activity
NHM99_09135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NHM99_09150	COG2244	polysaccharide biosynthetic process
NHM99_09155	COG0733	neurotransmitter:sodium symporter activity
NHM99_09165	COG5566	PFAM Mor transcription activator
NHM99_09170	COG2323	membrane
NHM99_09185	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHM99_09190	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHM99_09195	COG0028	Belongs to the TPP enzyme family
NHM99_09200	COG0440	acetolactate synthase activity
NHM99_09205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NHM99_09215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NHM99_09240	COG2814	Major facilitator Superfamily
NHM99_09245	COG3384	dioxygenase
NHM99_09255	COG3279	Response regulator of the LytR AlgR family
NHM99_09260	COG0427	acetyl-CoA hydrolase
NHM99_09280	COG1073	alpha beta
NHM99_09285	COG4166	transmembrane transport
NHM99_09290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_09295	COG0745	RESPONSE REGULATOR receiver
NHM99_09310	COG1914	H( )-stimulated, divalent metal cation uptake system
NHM99_09325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NHM99_09330	COG0531	amino acid
NHM99_09350	COG0457	Tetratricopeptide repeat
NHM99_09360	COG2390	Transcriptional regulator
NHM99_09370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHM99_09375	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NHM99_09385	COG4846	Membrane protein involved in cytochrome C biogenesis
NHM99_09395	COG0006	proline dipeptidase activity
NHM99_09410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHM99_09430	COG1114	Component of the transport system for branched-chain amino acids
NHM99_09440	COG1276	copper resistance
NHM99_09440	COG2372	response to copper ion
NHM99_09445	COG4549	nuclear export factor GLE1
NHM99_09450	COG0697	spore germination
NHM99_09455	COG0583	DNA-binding transcription factor activity
NHM99_09460	COG1959	2 iron, 2 sulfur cluster binding
NHM99_09465	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NHM99_09470	COG0778	Nitroreductase
NHM99_09480	COG0628	permease
NHM99_09490	COG1231	oxidoreductase activity
NHM99_09505	COG0411	ABC transporter
NHM99_09525	COG0583	DNA-binding transcription factor activity
NHM99_09535	COG1942	4-Oxalocrotonate Tautomerase
NHM99_09555	COG1271	oxidase subunit
NHM99_09560	COG1294	oxidase, subunit
NHM99_09565	COG4988	ABC transporter
NHM99_09570	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NHM99_09580	COG1216	Glycosyl transferase, family 2
NHM99_09620	COG1686	Belongs to the peptidase S11 family
NHM99_09635	COG1388	LysM domain
NHM99_09635	COG0791	NLP P60 protein
NHM99_09645	COG1132	(ABC) transporter
NHM99_09650	COG0745	RESPONSE REGULATOR receiver
NHM99_09655	COG5002	protein histidine kinase activity
NHM99_09665	COG0300	oxidoreductase activity
NHM99_09670	COG4122	O-methyltransferase activity
NHM99_09725	COG1316	TRANSCRIPTIONal
NHM99_09745	COG1285	pathogenesis
NHM99_09750	COG1247	-acetyltransferase
NHM99_09760	COG2814	Major facilitator Superfamily
NHM99_09765	COG1279	arginine transmembrane transporter activity
NHM99_09770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_09780	COG1752	Esterase of the alpha-beta hydrolase superfamily
NHM99_09815	COG0577	efflux transmembrane transporter activity
NHM99_09820	COG2002	toxin-antitoxin pair type II binding
NHM99_09825	COG1404	Belongs to the peptidase S8 family
NHM99_09830	COG3842	ATPase activity
NHM99_09835	COG2508	Transcriptional regulator
NHM99_09850	COG1175	transmembrane transport
NHM99_09855	COG0395	ABC-type sugar transport system, permease component
NHM99_09860	COG5426	von Willebrand factor, type A
NHM99_09870	COG1940	carbohydrate kinase activity
NHM99_09875	COG2222	sugar isomerase
NHM99_09890	COG3684	Belongs to the aldolase LacD family
NHM99_09895	COG0366	Alpha amylase catalytic
NHM99_09900	COG0366	Alpha amylase catalytic
NHM99_09905	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NHM99_09910	COG0640	Transcriptional regulator
NHM99_09915	COG0667	Aldo Keto reductase
NHM99_09920	COG2814	Major facilitator Superfamily
NHM99_09945	COG0840	transmembrane signaling receptor activity
NHM99_09960	COG3949	Membrane
NHM99_09965	COG0783	Belongs to the Dps family
NHM99_09980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHM99_09990	COG1231	oxidoreductase activity
NHM99_09995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_10000	COG4989	oxidoreductase activity
NHM99_10005	COG0523	cobalamin synthesis protein
NHM99_10010	COG0456	acetyltransferase
NHM99_10015	COG3443	Belongs to the bacterial solute-binding protein 9 family
NHM99_10015	COG0803	Belongs to the bacterial solute-binding protein 9 family
NHM99_10025	COG0702	epimerase
NHM99_10035	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NHM99_10045	COG4166	transmembrane transport
NHM99_10060	COG0406	alpha-ribazole phosphatase activity
NHM99_10070	COG5337	Spore coat protein CotH
NHM99_10075	COG1051	belongs to the nudix hydrolase family
NHM99_10080	COG0586	Pfam SNARE associated Golgi protein
NHM99_10085	COG2244	polysaccharide biosynthetic process
NHM99_10095	COG0701	Predicted permease
NHM99_10105	COG1607	acyl-coa hydrolase
NHM99_10115	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHM99_10130	COG0702	epimerase
NHM99_10135	COG2839	Protein conserved in bacteria
NHM99_10140	COG1253	flavin adenine dinucleotide binding
NHM99_10155	COG1114	Component of the transport system for branched-chain amino acids
NHM99_10160	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHM99_10180	COG0860	N-Acetylmuramoyl-L-alanine amidase
NHM99_10190	COG1876	peptidase activity
NHM99_10200	COG0154	amidase activity
NHM99_10205	COG2211	Major facilitator Superfamily
NHM99_10225	COG0561	phosphatase activity
NHM99_10235	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NHM99_10255	COG1819	glycosyl
NHM99_10260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_10265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_10295	COG0456	acetyltransferase
NHM99_10320	COG3874	Sporulation protein YtfJ
NHM99_10345	COG2226	methyltransferase
NHM99_10370	COG0582	viral genome integration into host DNA
NHM99_10380	COG3620	sequence-specific DNA binding
NHM99_10420	COG2002	toxin-antitoxin pair type II binding
NHM99_10495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NHM99_10500	COG0582	viral genome integration into host DNA
NHM99_10535	COG1802	Transcriptional regulator
NHM99_10535	COG4626	Terminase
NHM99_10545	COG0740	serine-type endopeptidase activity
NHM99_10680	COG0604	alcohol dehydrogenase
NHM99_10685	COG1595	DNA-templated transcription, initiation
NHM99_10700	COG0426	domain, Protein
NHM99_10700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NHM99_10710	COG0386	Belongs to the glutathione peroxidase family
NHM99_10720	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NHM99_10725	COG0714	Associated with various cellular activities
NHM99_10730	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NHM99_10735	COG1140	nitrate reductase beta subunit
NHM99_10740	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NHM99_10745	COG2181	nitrate reductase activity
NHM99_10750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NHM99_10755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NHM99_10760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NHM99_10765	COG0303	'Molybdopterin
NHM99_10770	COG0314	molybdopterin synthase activity
NHM99_10780	COG2223	nitrite transmembrane transporter activity
NHM99_10800	COG1648	precorrin-2 dehydrogenase activity
NHM99_10810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NHM99_10810	COG1587	Uroporphyrinogen-III synthase
NHM99_10815	COG2146	nitrite reductase [NAD(P)H] activity
NHM99_10820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NHM99_10825	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
NHM99_10860	COG2359	stage V sporulation protein S
NHM99_10880	COG1418	mRNA catabolic process
NHM99_10885	COG0488	(ABC) transporter
NHM99_10900	COG0629	single-stranded DNA binding
NHM99_10915	COG1413	lyase activity
NHM99_10930	COG2136	Putative SAM-dependent methyltransferase
NHM99_10930	COG2521	methyltransferase
NHM99_10980	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NHM99_10985	COG0017	Asparaginyl-tRNA synthetase
NHM99_10990	COG0733	neurotransmitter:sodium symporter activity
NHM99_11015	COG2610	gluconate transmembrane transporter activity
NHM99_11020	COG1454	alcohol dehydrogenase
NHM99_11025	COG1794	racemase activity, acting on amino acids and derivatives
NHM99_11035	COG0456	acetyltransferase
NHM99_11040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NHM99_11050	COG1131	(ABC) transporter
NHM99_11055	COG4473	ABC transporter
NHM99_11065	COG0546	phosphoglycolate phosphatase activity
NHM99_11080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NHM99_11085	COG3250	beta-galactosidase activity
NHM99_11100	COG0768	penicillin binding
NHM99_11110	COG0204	Acyl-transferase
NHM99_11115	COG1272	protein, Hemolysin III
NHM99_11135	COG1307	EDD domain protein, DegV family
NHM99_11140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NHM99_11145	COG1999	signal sequence binding
NHM99_11150	COG0071	Belongs to the small heat shock protein (HSP20) family
NHM99_11155	COG0367	asparagine synthase
NHM99_11175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_11180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NHM99_11195	COG1335	isochorismatase
NHM99_11200	COG1051	belongs to the nudix hydrolase family
NHM99_11210	COG0668	transmembrane transport
NHM99_11215	COG4585	Histidine kinase
NHM99_11215	COG2203	Gaf domain
NHM99_11220	COG2197	response regulator
NHM99_11230	COG1064	alcohol dehydrogenase
NHM99_11290	COG1174	glycine betaine transport
NHM99_11325	COG1253	flavin adenine dinucleotide binding
NHM99_11330	COG1012	belongs to the aldehyde dehydrogenase family
NHM99_11335	COG5506	Protein of unknown function (DUF1694)
NHM99_11350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHM99_11355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NHM99_11360	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NHM99_11365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHM99_11370	COG0456	acetyltransferase
NHM99_11375	COG3829	transcription factor binding
NHM99_11380	COG1509	lysine 2,3-aminomutase activity
NHM99_11415	COG0515	serine threonine protein kinase
NHM99_11415	COG4991	sh3 domain protein
NHM99_11415	COG3064	Membrane
NHM99_11420	COG4326	sporulation control protein
NHM99_11425	COG0671	phosphoesterase, PA-phosphatase related
NHM99_11430	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NHM99_11435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHM99_11450	COG3728	DNA packaging
NHM99_11450	COG5484	DNA packaging
NHM99_11485	COG1595	DNA-templated transcription, initiation
NHM99_11570	COG4499	WXG100 protein secretion system (Wss), protein YukC
NHM99_11570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHM99_11580	COG2814	Major facilitator Superfamily
NHM99_11585	COG4841	protein insertion into membrane
NHM99_11590	COG0372	Belongs to the citrate synthase family
NHM99_11595	COG2079	MmgE PrpD family protein
NHM99_11600	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NHM99_11605	COG1960	acyl-CoA dehydrogenase activity
NHM99_11610	COG2084	Dehydrogenase
NHM99_11620	COG1280	lysine exporter protein (LysE YggA)
NHM99_11625	COG1024	Enoyl-CoA hydratase
NHM99_11640	COG0420	3'-5' exonuclease activity
NHM99_11670	COG2223	nitrite transmembrane transporter activity
NHM99_11675	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_11680	COG1169	isochorismate synthase
NHM99_11685	COG1021	2,3-dihydroxybenzoate-AMP ligase
NHM99_11690	COG1535	isochorismatase
NHM99_11690	COG3433	isochorismatase activity
NHM99_11695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NHM99_11705	COG2814	Major facilitator Superfamily
NHM99_11720	COG0776	regulation of translation
NHM99_11740	COG1115	amino acid carrier protein
NHM99_11765	COG2329	Antibiotic biosynthesis monooxygenase
NHM99_11770	COG1187	pseudouridine synthase activity
NHM99_11775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHM99_11780	COG1136	(ABC) transporter
NHM99_11790	COG2814	Major facilitator Superfamily
NHM99_11805	COG0028	Belongs to the TPP enzyme family
NHM99_11815	COG2226	methyltransferase
NHM99_11885	COG1247	-acetyltransferase
NHM99_11910	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NHM99_11915	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NHM99_11925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_11950	COG0010	Belongs to the arginase family
NHM99_11955	COG0561	phosphatase activity
NHM99_11965	COG1846	Transcriptional regulator
NHM99_11970	COG2814	Major facilitator Superfamily
NHM99_11975	COG0583	DNA-binding transcription factor activity
NHM99_11980	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NHM99_11995	COG0583	DNA-binding transcription factor activity
NHM99_12000	COG2258	MOSC domain
NHM99_12015	COG1132	(ABC) transporter
NHM99_12020	COG1132	(ABC) transporter
NHM99_12035	COG1396	sequence-specific DNA binding
NHM99_12080	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
NHM99_12085	COG1595	DNA-templated transcription, initiation
NHM99_12110	COG1649	PFAM Uncharacterised BCR, COG1649
NHM99_12135	COG2971	BadF BadG BcrA BcrD
NHM99_12145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NHM99_12165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_12200	COG1309	transcriptional regulator
NHM99_12215	COG1136	(ABC) transporter
NHM99_12215	COG0577	efflux transmembrane transporter activity
NHM99_12220	COG3615	Tellurite resistance protein tehB
NHM99_12220	COG0500	methyltransferase
NHM99_12235	COG3961	Belongs to the TPP enzyme family
NHM99_12265	COG2195	Cleaves the N-terminal amino acid of tripeptides
NHM99_12280	COG1595	DNA-templated transcription, initiation
NHM99_12290	COG0768	penicillin binding
NHM99_12295	COG0768	penicillin binding
NHM99_12300	COG2367	Beta-lactamase
NHM99_12315	COG1131	(ABC) transporter
NHM99_12325	COG1309	transcriptional regulator
NHM99_12340	COG1960	acyl-CoA dehydrogenase activity
NHM99_12345	COG0439	Biotin carboxylase
NHM99_12350	COG0511	ligase activity, forming carbon-carbon bonds
NHM99_12355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NHM99_12360	COG1024	Enoyl-CoA hydratase
NHM99_12365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NHM99_12370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHM99_12385	COG0572	uridine kinase
NHM99_12395	COG2318	DinB family
NHM99_12400	COG1686	Belongs to the peptidase S11 family
NHM99_12425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NHM99_12445	COG3227	Zinc metalloprotease (Elastase)
NHM99_12480	COG2814	Major facilitator Superfamily
NHM99_12490	COG2226	methyltransferase
NHM99_12520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_12535	COG1063	alcohol dehydrogenase
NHM99_12545	COG2323	membrane
NHM99_12550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NHM99_12565	COG3386	PFAM SMP-30 Gluconolaconase
NHM99_12580	COG3773	Cell wall hydrolase
NHM99_12590	COG0745	RESPONSE REGULATOR receiver
NHM99_12595	COG2205	protein histidine kinase activity
NHM99_12605	COG0488	(ABC) transporter
NHM99_12610	COG1136	(ABC) transporter
NHM99_12615	COG0577	efflux transmembrane transporter activity
NHM99_12635	COG0460	homoserine dehydrogenase
NHM99_12640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_12650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NHM99_12785	COG2124	cytochrome p450
NHM99_12815	COG0561	phosphatase activity
NHM99_12820	COG5002	protein histidine kinase activity
NHM99_12825	COG0768	penicillin binding
NHM99_12835	COG1794	racemase activity, acting on amino acids and derivatives
NHM99_12860	COG2205	protein histidine kinase activity
NHM99_12870	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NHM99_12875	COG0604	alcohol dehydrogenase
NHM99_12880	COG0671	phosphoesterase, PA-phosphatase related
NHM99_12885	COG0768	penicillin binding
NHM99_12895	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_12955	COG0584	glycerophosphoryl diester phosphodiesterase
NHM99_12980	COG0697	spore germination
NHM99_12990	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NHM99_13005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NHM99_13015	COG2223	nitrite transmembrane transporter activity
NHM99_13030	COG2816	NAD+ diphosphatase activity
NHM99_13040	COG1051	belongs to the nudix hydrolase family
NHM99_13070	COG3878	Protein conserved in bacteria
NHM99_13100	COG4667	esterase of the alpha-beta hydrolase superfamily
NHM99_13140	COG0322	excinuclease ABC activity
NHM99_13170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHM99_13195	COG1011	Hydrolase
NHM99_13215	COG1523	belongs to the glycosyl hydrolase 13 family
NHM99_13220	COG3227	Zinc metalloprotease (Elastase)
NHM99_13230	COG0346	lactoylglutathione lyase activity
NHM99_13235	COG0201	protein transport
NHM99_13275	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_13290	COG2959	enzyme of heme biosynthesis
NHM99_13330	COG1309	transcriptional regulator
NHM99_13360	COG3284	Transcriptional regulator
NHM99_13375	COG1349	DNA-binding transcription factor activity
NHM99_13390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHM99_13395	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHM99_13400	COG0022	dehydrogenase e1 component
NHM99_13405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NHM99_13415	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_13420	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NHM99_13420	COG0456	acetyltransferase
NHM99_13425	COG0572	uridine kinase
NHM99_13460	COG4176	ABC-type proline glycine betaine transport system permease component
NHM99_13465	COG4175	Glycine betaine
NHM99_13465	COG0517	IMP dehydrogenase activity
NHM99_13490	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NHM99_13495	COG2153	protein acetylation
NHM99_13500	COG3397	chitin binding
NHM99_13505	COG1819	glycosyl
NHM99_13520	COG2205	protein histidine kinase activity
NHM99_13525	COG2226	methyltransferase
NHM99_13530	COG2315	Protein conserved in bacteria
NHM99_13540	COG0658	competence protein
NHM99_13540	COG2333	competence protein COMEC
NHM99_13580	COG3973	AAA domain
NHM99_13600	COG0514	ATP-dependent DNA helicase (RecQ)
NHM99_13630	COG4637	Psort location Cytoplasmic, score
NHM99_13650	COG3397	chitin binding
NHM99_13670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NHM99_13675	COG1115	amino acid carrier protein
NHM99_13680	COG1012	belongs to the aldehyde dehydrogenase family
NHM99_13685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NHM99_13695	COG3938	Belongs to the proline racemase family
NHM99_13700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NHM99_13745	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NHM99_13750	COG0519	Catalyzes the synthesis of GMP from XMP
NHM99_13755	COG4166	transmembrane transport
NHM99_13765	COG4948	Mandelate Racemase Muconate Lactonizing
NHM99_13815	COG2936	dipeptidyl-peptidase activity
NHM99_13820	COG5002	protein histidine kinase activity
NHM99_13825	COG0745	RESPONSE REGULATOR receiver
NHM99_13870	COG1307	EDD domain protein, DegV family
NHM99_13910	COG2814	Major facilitator Superfamily
NHM99_13920	COG1664	Polymer-forming cytoskeletal
NHM99_13925	COG0789	Transcriptional regulator
NHM99_13930	COG4533	DNA binding
NHM99_13935	COG0477	Major facilitator Superfamily
NHM99_13935	COG2814	Major facilitator Superfamily
NHM99_13960	COG2261	transglycosylase associated protein
NHM99_13975	COG2226	methyltransferase
NHM99_14005	COG0436	Aminotransferase
NHM99_14010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NHM99_14015	COG5146	pantothenate kinase activity
NHM99_14020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NHM99_14075	COG0628	permease
NHM99_14090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NHM99_14095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHM99_14145	COG2746	aminoglycoside 3-N-acetyltransferase activity
NHM99_14165	COG0697	spore germination
NHM99_14170	COG2318	DinB family
NHM99_14190	COG4912	Dna alkylation repair
NHM99_14200	COG0346	lactoylglutathione lyase activity
NHM99_14220	COG0861	Integral membrane protein TerC family
NHM99_14225	COG1368	sulfuric ester hydrolase activity
NHM99_14230	COG0488	(ABC) transporter
NHM99_14240	COG2409	Drug exporters of the RND superfamily
NHM99_14240	COG1033	growth of symbiont in host cell
NHM99_14245	COG1309	transcriptional regulator
NHM99_14260	COG0287	Prephenate dehydrogenase
NHM99_14265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NHM99_14275	COG1605	Chorismate mutase
NHM99_14275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NHM99_14305	COG1388	LysM domain
NHM99_14305	COG3584	3D domain protein
NHM99_14335	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHM99_14345	COG2390	Transcriptional regulator
NHM99_14350	COG1070	Carbohydrate kinase
NHM99_14370	COG2329	Antibiotic biosynthesis monooxygenase
NHM99_14385	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHM99_14400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHM99_14405	COG4187	Peptidase family M20/M25/M40
NHM99_14410	COG1414	Transcriptional regulator
NHM99_14415	COG0833	amino acid
NHM99_14420	COG1690	Belongs to the RtcB family
NHM99_14425	COG3239	Fatty acid desaturase
NHM99_14435	COG1785	Belongs to the alkaline phosphatase family
NHM99_14445	COG3655	Transcriptional regulator
NHM99_14460	COG4377	Putative membrane peptidase family (DUF2324)
NHM99_14470	COG3279	Response regulator of the LytR AlgR family
NHM99_14485	COG0346	lactoylglutathione lyase activity
NHM99_14505	COG0714	Associated with various cellular activities
NHM99_14525	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHM99_14530	COG0753	catalase activity
NHM99_14535	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHM99_14555	COG1846	Transcriptional regulator
NHM99_14560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NHM99_14585	COG0714	Associated with various cellular activities
NHM99_14595	COG0778	Nitroreductase
NHM99_14600	COG1846	Transcriptional regulator
NHM99_14635	COG1725	Transcriptional regulator
NHM99_14645	COG1136	(ABC) transporter
NHM99_14675	COG0456	acetyltransferase
NHM99_14690	COG0697	spore germination
NHM99_14695	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_14735	COG0730	response to heat
NHM99_14745	COG0833	amino acid
NHM99_14755	COG4335	DNA alkylation repair
NHM99_14795	COG0768	penicillin binding
NHM99_14830	COG1984	allophanate hydrolase subunit 2
NHM99_14835	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NHM99_14840	COG1414	Transcriptional regulator
NHM99_14850	COG3142	Participates in the control of copper homeostasis
NHM99_14855	COG0860	N-Acetylmuramoyl-L-alanine amidase
NHM99_14860	COG0640	Transcriptional regulator
NHM99_14870	COG2814	Major facilitator Superfamily
NHM99_14880	COG1960	acyl-CoA dehydrogenase activity
NHM99_14895	COG3314	Sporulation integral membrane protein YlbJ
NHM99_14920	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NHM99_14935	COG3848	Pyruvate phosphate dikinase
NHM99_14935	COG0574	Belongs to the PEP-utilizing enzyme family
NHM99_14945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_14960	COG5577	PFAM Coat F domain
NHM99_14965	COG3403	YqcI/YcgG family
NHM99_14970	COG1280	lysine exporter protein (LysE YggA)
NHM99_14975	COG1113	amino acid transport
NHM99_15005	COG1063	alcohol dehydrogenase
NHM99_15020	COG0252	asparaginase activity
NHM99_15025	COG1396	sequence-specific DNA binding
NHM99_15035	COG0322	excinuclease ABC activity
NHM99_15040	COG0531	amino acid
NHM99_15045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHM99_15055	COG0531	amino acid
NHM99_15060	COG0697	spore germination
NHM99_15065	COG0784	Response regulator, receiver
NHM99_15070	COG4191	Histidine kinase
NHM99_15075	COG2066	Belongs to the glutaminase family
NHM99_15080	COG1115	amino acid carrier protein
NHM99_15105	COG0534	Mate efflux family protein
NHM99_15115	COG0531	amino acid
NHM99_15120	COG0737	Belongs to the 5'-nucleotidase family
NHM99_15125	COG0753	catalase activity
NHM99_15135	COG0598	Magnesium transport protein CorA
NHM99_15190	COG0415	Belongs to the DNA photolyase family
NHM99_15205	COG0288	reversible hydration of carbon dioxide
NHM99_15215	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NHM99_15220	COG5609	conserved protein (DUF2294)
NHM99_15235	COG0697	spore germination
NHM99_15245	COG1575	Belongs to the MenA family. Type 1 subfamily
NHM99_15250	COG4641	Protein conserved in bacteria
NHM99_15275	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_15275	COG3347	Dehydrogenase
NHM99_15285	COG1070	Carbohydrate kinase
NHM99_15290	COG0235	Class ii aldolase
NHM99_15300	COG1172	Belongs to the binding-protein-dependent transport system permease family
NHM99_15310	COG4154	Belongs to the RbsD FucU family
NHM99_15325	COG0798	PFAM Bile acid sodium symporter
NHM99_15330	COG0346	lactoylglutathione lyase activity
NHM99_15335	COG0640	Transcriptional regulator
NHM99_15345	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NHM99_15365	COG1136	(ABC) transporter
NHM99_15405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHM99_15405	COG3320	Male sterility
NHM99_15410	COG1309	transcriptional regulator
NHM99_15415	COG2814	Major facilitator Superfamily
NHM99_15420	COG1309	transcriptional regulator
NHM99_15425	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_15430	COG1522	sequence-specific DNA binding
NHM99_15445	COG0346	lactoylglutathione lyase activity
NHM99_15480	COG2814	Major facilitator Superfamily
NHM99_15490	COG4895	conserved protein (DUF2196)
NHM99_15540	COG2515	1-aminocyclopropane-1-carboxylate deaminase
NHM99_15560	COG0789	Transcriptional regulator
NHM99_15565	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NHM99_15585	COG0577	efflux transmembrane transporter activity
NHM99_15605	COG5002	protein histidine kinase activity
NHM99_15605	COG3850	Histidine kinase
NHM99_15615	COG2364	Membrane
NHM99_15620	COG1846	Transcriptional regulator
NHM99_15625	COG0456	acetyltransferase
NHM99_15630	COG2808	Putative FMN-binding domain
NHM99_15635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_15665	COG1619	proteins homologs of microcin C7 resistance protein MccF
NHM99_15680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NHM99_15700	COG0662	Cupin 2, conserved barrel domain protein
NHM99_15705	COG2207	Transcriptional regulator
NHM99_15705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_15725	COG3409	Peptidoglycan-binding domain 1 protein
NHM99_15725	COG5632	N-Acetylmuramoyl-L-alanine amidase
NHM99_15765	COG0477	Major facilitator Superfamily
NHM99_15780	COG1846	Transcriptional regulator
NHM99_15785	COG2814	Major facilitator Superfamily
NHM99_15795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NHM99_15800	COG1131	(ABC) transporter
NHM99_15820	COG2076	Multidrug Resistance protein
NHM99_15825	COG1309	transcriptional regulator
NHM99_15840	COG2031	fatty acid transporter
NHM99_15850	COG2249	NAD(P)H dehydrogenase (quinone) activity
NHM99_15885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NHM99_15900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
NHM99_15905	COG1288	antiporter activity
NHM99_15925	COG0789	Transcriptional regulator
NHM99_15945	COG3344	reverse transcriptase
NHM99_15950	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NHM99_15950	COG0456	acetyltransferase
NHM99_15955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NHM99_15975	COG1733	regulation of RNA biosynthetic process
NHM99_15980	COG0778	Nitroreductase
NHM99_16000	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_16010	COG1131	(ABC) transporter
NHM99_16035	COG1011	Hydrolase
NHM99_16060	COG0346	lactoylglutathione lyase activity
NHM99_16065	COG1940	carbohydrate kinase activity
NHM99_16070	COG0110	maltose O-acetyltransferase activity
NHM99_16085	COG0628	permease
NHM99_16115	COG2226	methyltransferase
NHM99_16125	COG0477	Major facilitator Superfamily
NHM99_16150	COG1253	flavin adenine dinucleotide binding
NHM99_16155	COG0789	Transcriptional regulator
NHM99_16165	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NHM99_16195	COG0697	spore germination
NHM99_16200	COG1357	PFAM Pentapeptide repeats (8 copies)
NHM99_16205	COG3813	Protein conserved in bacteria
NHM99_16210	COG2706	6-phosphogluconolactonase activity
NHM99_16215	COG1070	Carbohydrate kinase
NHM99_16225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NHM99_16230	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NHM99_16240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NHM99_16245	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NHM99_16250	COG0604	alcohol dehydrogenase
NHM99_16265	COG0604	alcohol dehydrogenase
NHM99_16265	COG3321	synthase
NHM99_16270	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_16285	COG0656	L-ascorbic acid biosynthetic process
NHM99_16290	COG2814	Major facilitator Superfamily
NHM99_16305	COG0814	amino acid
NHM99_16310	COG3344	reverse transcriptase
NHM99_16335	COG1393	Belongs to the ArsC family
NHM99_16340	COG1733	regulation of RNA biosynthetic process
NHM99_16345	COG2188	Transcriptional regulator
NHM99_16350	COG0673	inositol 2-dehydrogenase activity
NHM99_16355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
NHM99_16360	COG1733	regulation of RNA biosynthetic process
NHM99_16365	COG1733	regulation of RNA biosynthetic process
NHM99_16385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_16405	COG0384	phenazine biosynthesis protein PhzF
NHM99_16425	COG0318	PFAM AMP-dependent synthetase and ligase
NHM99_16430	COG2249	NAD(P)H dehydrogenase (quinone) activity
NHM99_16435	COG1733	regulation of RNA biosynthetic process
NHM99_16465	COG1266	CAAX protease self-immunity
NHM99_16470	COG1309	transcriptional regulator
NHM99_16515	COG1151	hydroxylamine reductase activity
NHM99_16525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_16555	COG2072	flavoprotein involved in K transport
NHM99_16600	COG1695	Transcriptional regulator
NHM99_16605	COG0604	alcohol dehydrogenase
NHM99_16610	COG1113	amino acid transport
NHM99_16615	COG2814	Major facilitator Superfamily
NHM99_16640	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NHM99_16645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NHM99_16660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_16665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_16670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_16675	COG3739	integral membrane protein
NHM99_16705	COG0583	DNA-binding transcription factor activity
NHM99_16725	COG1193	negative regulation of DNA recombination
NHM99_16730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NHM99_16735	COG1164	Oligoendopeptidase f
NHM99_16740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NHM99_16770	COG0584	glycerophosphoryl diester phosphodiesterase
NHM99_16780	COG0640	Transcriptional regulator
NHM99_16785	COG0604	alcohol dehydrogenase
NHM99_16795	COG0457	Tetratricopeptide repeat
NHM99_16805	COG2808	Putative FMN-binding domain
NHM99_16810	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NHM99_16820	COG0385	Bile acid
NHM99_16825	COG0277	FAD linked oxidase domain protein
NHM99_16855	COG1285	pathogenesis
NHM99_16870	COG2514	catechol 2,3-dioxygenase activity
NHM99_16875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHM99_16880	COG1126	abc transporter atp-binding protein
NHM99_16885	COG0765	amino acid transport
NHM99_16890	COG2720	vancomycin resistance protein
NHM99_16930	COG0716	FMN binding
NHM99_16940	COG0494	nUDIX hydrolase
NHM99_16960	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_16970	COG0165	Argininosuccinate lyase
NHM99_16985	COG4145	pantothenate transmembrane transporter activity
NHM99_17035	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_17050	COG1657	PFAM Prenyltransferase squalene oxidase
NHM99_17055	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NHM99_17060	COG2962	Rard protein
NHM99_17065	COG3326	Membrane
NHM99_17080	COG0489	protein tyrosine kinase activity
NHM99_17090	COG0314	molybdopterin synthase activity
NHM99_17095	COG0303	'Molybdopterin
NHM99_17100	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NHM99_17105	COG2116	formate transmembrane transporter activity
NHM99_17115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NHM99_17120	COG5609	conserved protein (DUF2294)
NHM99_17125	COG2427	Protein of unknown function (DUF1641)
NHM99_17130	COG3383	formate dehydrogenase (NAD+) activity
NHM99_17135	COG0697	spore germination
NHM99_17175	COG2226	methyltransferase
NHM99_17180	COG4166	transmembrane transport
NHM99_17185	COG4166	transmembrane transport
NHM99_17195	COG1301	dicarboxylic acid transport
NHM99_17200	COG1316	TRANSCRIPTIONal
NHM99_17210	COG1595	DNA-templated transcription, initiation
NHM99_17215	COG0346	lactoylglutathione lyase activity
NHM99_17225	COG1131	(ABC) transporter
NHM99_17235	COG0673	inositol 2-dehydrogenase activity
NHM99_17240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NHM99_17245	COG0187	DNA topoisomerase II activity
NHM99_17250	COG1832	CoA-binding protein
NHM99_17255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHM99_17260	COG0745	RESPONSE REGULATOR receiver
NHM99_17270	COG1328	CTP reductase activity
NHM99_17270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NHM99_17280	COG4841	protein insertion into membrane
NHM99_17285	COG0824	Thioesterase
NHM99_17315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHM99_17325	COG1132	(ABC) transporter
NHM99_17330	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NHM99_17360	COG2211	Major facilitator Superfamily
NHM99_17360	COG2211	Major facilitator Superfamily
NHM99_17365	COG4282	regulation of fungal-type cell wall biogenesis
NHM99_17385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NHM99_17410	COG0183	Belongs to the thiolase family
NHM99_17415	COG0318	PFAM AMP-dependent synthetase and ligase
NHM99_17420	COG1268	BioY protein
NHM99_17425	COG0318	PFAM AMP-dependent synthetase and ligase
NHM99_17440	COG1396	sequence-specific DNA binding
NHM99_17485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_17500	COG0400	carboxylic ester hydrolase activity
NHM99_17505	COG0346	lactoylglutathione lyase activity
NHM99_17510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NHM99_17520	COG0069	glutamate synthase activity
NHM99_17530	COG1329	Transcriptional regulator
NHM99_17535	COG0010	Belongs to the arginase family
NHM99_17560	COG2226	methyltransferase
NHM99_17600	COG3344	reverse transcriptase
NHM99_17610	COG4846	Membrane protein involved in cytochrome C biogenesis
NHM99_17615	COG0785	Cytochrome C biogenesis protein
NHM99_17625	COG1473	amidohydrolase
NHM99_17635	COG1131	(ABC) transporter
NHM99_17645	COG0583	DNA-binding transcription factor activity
NHM99_17655	COG1346	cytolysis
NHM99_17670	COG0730	response to heat
NHM99_17680	COG3409	Peptidoglycan-binding domain 1 protein
NHM99_17680	COG5632	N-Acetylmuramoyl-L-alanine amidase
NHM99_17695	COG1132	(ABC) transporter
NHM99_17700	COG1132	(ABC) transporter
NHM99_17815	COG3639	organic phosphonate transmembrane transporter activity
NHM99_17820	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
NHM99_17830	COG0737	Belongs to the 5'-nucleotidase family
NHM99_17840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHM99_17860	COG1695	Transcriptional regulator
NHM99_17865	COG0174	glutamine synthetase
NHM99_17870	COG0789	Transcriptional regulator
NHM99_17875	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NHM99_17880	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NHM99_17885	COG2860	membrane
NHM99_17890	COG0464	growth
NHM99_17920	COG1388	LysM domain
NHM99_17920	COG3584	3D domain protein
NHM99_17925	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHM99_17925	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NHM99_17925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHM99_17930	COG1105	Belongs to the carbohydrate kinase PfkB family
NHM99_17935	COG1349	DNA-binding transcription factor activity
NHM99_17940	COG1979	alcohol dehydrogenase
NHM99_17945	COG2322	membrane
NHM99_17955	COG1113	amino acid transport
NHM99_17965	COG1408	metallophosphoesterase
NHM99_17970	COG2116	formate transmembrane transporter activity
NHM99_17985	COG2217	Heavy metal translocating P-type atpase
NHM99_17990	COG2608	mercury ion transmembrane transporter activity
NHM99_17995	COG1937	Protein conserved in bacteria
NHM99_18005	COG2819	hydrolase of the alpha beta superfamily
NHM99_18010	COG1120	ATPase activity
NHM99_18015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_18020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_18025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_18035	COG2169	Transcriptional regulator
NHM99_18040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NHM99_18045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NHM99_18055	COG2364	Membrane
NHM99_18065	COG3300	MHYT domain
NHM99_18065	COG5001	Diguanylate cyclase
NHM99_18085	COG1380	Effector of murein hydrolase LrgA
NHM99_18090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NHM99_18110	COG3773	Cell wall hydrolase
NHM99_18120	COG1368	sulfuric ester hydrolase activity
NHM99_18125	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NHM99_18135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NHM99_18160	COG1131	(ABC) transporter
NHM99_18185	COG4550	Control of competence regulator ComK, YlbF/YmcA
NHM99_18195	COG1013	pyruvate-flavodoxin oxidoreductase activity
NHM99_18200	COG0674	pyruvate-flavodoxin oxidoreductase activity
NHM99_18200	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
NHM99_18210	COG2359	stage V sporulation protein S
NHM99_18215	COG1692	metallophosphoesterase
NHM99_18220	COG1418	mRNA catabolic process
NHM99_18240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NHM99_18245	COG1426	Protein conserved in bacteria
NHM99_18260	COG0300	oxidoreductase activity
NHM99_18265	COG0612	Peptidase, M16
NHM99_18270	COG0612	Peptidase, M16
NHM99_18280	COG4603	Belongs to the binding-protein-dependent transport system permease family
NHM99_18285	COG3845	ABC transporter
NHM99_18290	COG1744	ABC transporter substrate-binding protein PnrA-like
NHM99_18295	COG2188	Transcriptional regulator
NHM99_18300	COG1674	ftsk spoiiie
NHM99_18310	COG0740	serine-type endopeptidase activity
NHM99_18315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NHM99_18325	COG0527	aspartate kinase activity
NHM99_18335	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NHM99_18340	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHM99_18345	COG1873	PFAM PRC-barrel domain
NHM99_18350	COG0612	Peptidase, M16
NHM99_18370	COG0196	riboflavin kinase activity
NHM99_18385	COG1550	Protein conserved in bacteria
NHM99_18395	COG1358	cellular component organization or biogenesis
NHM99_18400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NHM99_18405	COG0195	Participates in both transcription termination and antitermination
NHM99_18425	COG0750	zinc metalloprotease
NHM99_18435	COG4589	Belongs to the CDS family
NHM99_18450	COG0528	UMP kinase activity
NHM99_18480	COG4974	Belongs to the 'phage' integrase family
NHM99_18490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NHM99_18495	COG0758	DNA mediated transformation
NHM99_18500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NHM99_18540	COG1837	Belongs to the UPF0109 family
NHM99_18550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NHM99_18565	COG1196	nuclear chromosome segregation
NHM99_18575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NHM99_18580	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_18585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NHM99_18600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NHM99_18605	COG1461	Dihydroxyacetone kinase
NHM99_18610	COG1302	Protein conserved in bacteria
NHM99_18625	COG1564	THIamine pyrophosphokinase
NHM99_18630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NHM99_18640	COG2815	serine threonine protein kinase
NHM99_18640	COG0515	serine threonine protein kinase
NHM99_18645	COG0631	protein serine/threonine phosphatase activity
NHM99_18655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NHM99_18655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NHM99_18665	COG0242	peptide deformylase activity
NHM99_18670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NHM99_18675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NHM99_18695	COG1561	YicC-like family, N-terminal region
NHM99_18700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NHM99_18710	COG0006	proline dipeptidase activity
NHM99_18730	COG3069	C4-dicarboxylate transmembrane transporter activity
NHM99_18795	COG0564	pseudouridine synthase activity
NHM99_18815	COG3599	regulation of cell shape
NHM99_18820	COG2302	S4 RNA-binding domain
NHM99_18825	COG0762	integral membrane protein
NHM99_18835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NHM99_18845	COG1873	PFAM PRC-barrel domain
NHM99_18850	COG1191	sigma factor activity
NHM99_18855	COG1191	sigma factor activity
NHM99_18865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NHM99_18870	COG0849	cell division
NHM99_18875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NHM99_18890	COG0772	Belongs to the SEDS family
NHM99_18905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NHM99_18910	COG0768	penicillin binding
NHM99_18915	COG0768	penicillin binding
NHM99_18920	COG4839	cell division protein FtsL
NHM99_18935	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NHM99_18950	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NHM99_18955	COG1399	metal-binding, possibly nucleic acid-binding protein
NHM99_19085	COG0740	serine-type endopeptidase activity
NHM99_19095	COG1802	Transcriptional regulator
NHM99_19095	COG4626	Terminase
NHM99_19120	COG0582	viral genome integration into host DNA
NHM99_19190	COG1484	DNA-dependent DNA replication
NHM99_19220	COG1396	sequence-specific DNA binding
NHM99_19255	COG0582	viral genome integration into host DNA
NHM99_19265	COG3480	Lon protease (S16) C-terminal proteolytic domain
NHM99_19270	COG1752	Esterase of the alpha-beta hydrolase superfamily
NHM99_19275	COG3314	Sporulation integral membrane protein YlbJ
NHM99_19285	COG0742	ribosomal rna small subunit methyltransferase
NHM99_19305	COG3679	Belongs to the UPF0342 family
NHM99_19310	COG0406	alpha-ribazole phosphatase activity
NHM99_19325	COG2340	Cysteine-rich secretory protein family
NHM99_19340	COG3344	reverse transcriptase
NHM99_19350	COG3336	cytochrome c oxidase
NHM99_19385	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NHM99_19390	COG0772	Belongs to the SEDS family
NHM99_19400	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NHM99_19405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NHM99_19415	COG4896	Protein conserved in bacteria
NHM99_19430	COG1217	gtp-binding protein TYPA
NHM99_19440	COG0483	inositol monophosphate 1-phosphatase activity
NHM99_19460	COG1982	Orn Lys Arg decarboxylase major
NHM99_19510	COG0022	dehydrogenase e1 component
NHM99_19515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NHM99_19525	COG0242	peptide deformylase activity
NHM99_19530	COG0561	phosphatase activity
NHM99_19540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NHM99_19545	COG0569	domain protein
NHM99_19565	COG0583	DNA-binding transcription factor activity
NHM99_19570	COG0517	IMP dehydrogenase activity
NHM99_19580	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NHM99_19590	COG4703	Protein of unknown function (DUF1797)
NHM99_19610	COG2200	EAL domain
NHM99_19615	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_19620	COG1408	metallophosphoesterase
NHM99_19630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NHM99_19665	COG2814	Major facilitator Superfamily
NHM99_19690	COG3209	COG3209 Rhs family protein
NHM99_19700	COG2205	protein histidine kinase activity
NHM99_19710	COG0436	Aminotransferase
NHM99_19715	COG1609	Transcriptional regulator
NHM99_19720	COG3833	ABC-type maltose transport systems, permease component
NHM99_19725	COG1175	transmembrane transport
NHM99_19730	COG2182	Extracellular solute-binding protein
NHM99_19745	COG3842	ATPase activity
NHM99_19785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NHM99_19790	COG0183	Belongs to the thiolase family
NHM99_19820	COG1695	Transcriptional regulator
NHM99_19825	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_19850	COG3344	reverse transcriptase
NHM99_19855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NHM99_19860	COG0436	Aminotransferase
NHM99_19895	COG2084	Dehydrogenase
NHM99_19905	COG2199	diguanylate cyclase activity
NHM99_19910	COG0778	Nitroreductase
NHM99_19935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NHM99_19935	COG2190	(PTS) system
NHM99_19935	COG1263	PTS System
NHM99_19940	COG3711	transcriptional antiterminator
NHM99_19950	COG2188	Transcriptional regulator
NHM99_19965	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NHM99_19990	COG1547	Domain of unknown function (DUF309)
NHM99_20005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NHM99_20010	COG4086	secreted protein
NHM99_20015	COG0561	phosphatase activity
NHM99_20020	COG0697	spore germination
NHM99_20035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHM99_20060	COG0733	neurotransmitter:sodium symporter activity
NHM99_20080	COG1686	Belongs to the peptidase S11 family
NHM99_20085	COG1725	Transcriptional regulator
NHM99_20090	COG1131	(ABC) transporter
NHM99_20105	COG1846	Transcriptional regulator
NHM99_20125	COG0598	Magnesium transport protein CorA
NHM99_20150	COG4974	Belongs to the 'phage' integrase family
NHM99_20160	COG0735	belongs to the Fur family
NHM99_20165	COG1300	Membrane
NHM99_20185	COG0667	Aldo Keto reductase
NHM99_20190	COG0656	L-ascorbic acid biosynthetic process
NHM99_20195	COG0456	acetyltransferase
NHM99_20195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NHM99_20205	COG1525	nuclease
NHM99_20205	COG4085	toxin activity
NHM99_20205	COG0737	Belongs to the 5'-nucleotidase family
NHM99_20215	COG0596	Alpha beta hydrolase
NHM99_20220	COG2056	Na+-H+ antiporter family
NHM99_20225	COG1609	Transcriptional regulator
NHM99_20230	COG0456	acetyltransferase
NHM99_20235	COG1073	alpha beta
NHM99_20250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHM99_20250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NHM99_20255	COG0307	riboflavin synthase, alpha
NHM99_20280	COG4106	trans-aconitate 2-methyltransferase activity
NHM99_20285	COG1073	alpha beta
NHM99_20285	COG2226	methyltransferase
NHM99_20300	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NHM99_20310	COG1757	Na H antiporter
NHM99_20315	COG0737	Belongs to the 5'-nucleotidase family
NHM99_20325	COG1522	sequence-specific DNA binding
NHM99_20345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NHM99_20370	COG0300	oxidoreductase activity
NHM99_20375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_20380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHM99_20385	COG1760	l-serine dehydratase
NHM99_20390	COG1760	l-serine dehydratase
NHM99_20425	COG2195	Cleaves the N-terminal amino acid of tripeptides
NHM99_20430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_20445	COG1376	ErfK ybiS ycfS ynhG family protein
NHM99_20450	COG4129	membrane
NHM99_20455	COG1126	abc transporter atp-binding protein
NHM99_20460	COG0765	amino acid transport
NHM99_20465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NHM99_20480	COG2323	membrane
NHM99_20485	COG0772	Belongs to the SEDS family
NHM99_20490	COG0508	dehydrogenase complex catalyzes the overall conversion of
NHM99_20495	COG0022	dehydrogenase e1 component
NHM99_20500	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NHM99_20505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NHM99_20520	COG0280	phosphate acetyltransferase
NHM99_20525	COG3829	transcription factor binding
NHM99_20525	COG3290	protein histidine kinase activity
NHM99_20535	COG0584	glycerophosphoryl diester phosphodiesterase
NHM99_20540	COG3093	addiction module antidote protein HigA
NHM99_20545	COG0745	RESPONSE REGULATOR receiver
NHM99_20550	COG0750	zinc metalloprotease
NHM99_20555	COG0497	DNA recombination
NHM99_20565	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NHM99_20575	COG0142	geranyltranstransferase activity
NHM99_20600	COG1302	Protein conserved in bacteria
NHM99_20605	COG0439	Biotin carboxylase
NHM99_20610	COG0511	ligase activity, forming carbon-carbon bonds
NHM99_20655	COG3854	ATPases associated with a variety of cellular activities
NHM99_20680	COG0006	proline dipeptidase activity
NHM99_20695	COG3872	metal-dependent enzyme
NHM99_20735	COG0095	Lipoate-protein ligase
NHM99_20740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHM99_20745	COG1609	Transcriptional regulator
NHM99_20755	COG2076	Multidrug Resistance protein
NHM99_20760	COG2076	Multidrug Resistance protein
NHM99_20795	COG1131	(ABC) transporter
NHM99_20800	COG1725	Transcriptional regulator
NHM99_20830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHM99_20885	COG4970	Tfp pilus assembly protein FimT
NHM99_20895	COG1459	type II secretion system
NHM99_20900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NHM99_20955	COG1410	methionine synthase
NHM99_20955	COG0646	methionine synthase
NHM99_20960	COG0646	methionine synthase
NHM99_20960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NHM99_20965	COG0626	cystathionine gamma-synthase activity
NHM99_20970	COG0626	cystathionine gamma-synthase activity
NHM99_20990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_21000	COG1940	carbohydrate kinase activity
NHM99_21005	COG4483	Protein conserved in bacteria
NHM99_21010	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NHM99_21015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NHM99_21020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NHM99_21025	COG0704	Plays a role in the regulation of phosphate uptake
NHM99_21040	COG0573	inorganic phosphate transmembrane transporter activity
NHM99_21045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NHM99_21050	COG0768	penicillin binding
NHM99_21055	COG0477	Major facilitator Superfamily
NHM99_21060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NHM99_21085	COG0735	belongs to the Fur family
NHM99_21090	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NHM99_21095	COG1121	(ABC) transporter
NHM99_21100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_21130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NHM99_21135	COG2384	SAM-dependent methyltransferase
NHM99_21140	COG2010	Cytochrome c
NHM99_21145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NHM99_21150	COG0358	DNA primase activity
NHM99_21165	COG0517	IMP dehydrogenase activity
NHM99_21180	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NHM99_21185	COG0295	cytidine deaminase activity
NHM99_21190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NHM99_21200	COG1480	7TM receptor with intracellular HD hydrolase
NHM99_21205	COG1702	phosphate starvation-inducible protein PhoH
NHM99_21220	COG1610	YqeY-like protein
NHM99_21225	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NHM99_21230	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NHM99_21235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NHM99_21265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NHM99_21270	COG1733	regulation of RNA biosynthetic process
NHM99_21295	COG1466	dna polymerase III delta subunit
NHM99_21305	COG2333	competence protein COMEC
NHM99_21305	COG0658	competence protein
NHM99_21310	COG2131	deaminase
NHM99_21315	COG1555	photosystem II stabilization
NHM99_21315	COG1596	polysaccharide export
NHM99_21320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NHM99_21325	COG2226	methyltransferase
NHM99_21330	COG0799	negative regulation of ribosome biogenesis
NHM99_21335	COG1713	HD superfamily hydrolase involved in NAD metabolism
NHM99_21345	COG1534	Rna-binding protein
NHM99_21355	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NHM99_21360	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NHM99_21395	COG2357	RelA SpoT domain protein
NHM99_21405	COG1785	Belongs to the alkaline phosphatase family
NHM99_21410	COG0456	acetyltransferase
NHM99_21415	COG2267	carboxylic ester hydrolase activity
NHM99_21450	COG1404	Belongs to the peptidase S8 family
NHM99_21455	COG3186	Phenylalanine-4-hydroxylase
NHM99_21465	COG2514	catechol 2,3-dioxygenase activity
NHM99_21470	COG2259	Doxx family
NHM99_21510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NHM99_21520	COG1012	belongs to the aldehyde dehydrogenase family
NHM99_21520	COG1454	alcohol dehydrogenase
NHM99_21525	COG0626	cystathionine gamma-synthase activity
NHM99_21530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NHM99_21555	COG0768	penicillin binding
NHM99_21570	COG0826	peptidase U32
NHM99_21575	COG0826	peptidase U32
NHM99_21580	COG4122	O-methyltransferase activity
NHM99_21585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NHM99_21615	COG0628	permease
NHM99_21635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NHM99_21650	COG1104	cysteine desulfurase activity
NHM99_21655	COG1959	2 iron, 2 sulfur cluster binding
NHM99_21660	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NHM99_21670	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NHM99_21705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NHM99_21715	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NHM99_21715	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NHM99_21720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NHM99_21725	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHM99_21725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NHM99_21735	COG2244	polysaccharide biosynthetic process
NHM99_21740	COG2323	membrane
NHM99_21750	COG1862	Preprotein translocase
NHM99_21805	COG0157	Belongs to the NadC ModD family
NHM99_21810	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NHM99_21820	COG1827	regulation of RNA biosynthetic process
NHM99_21825	COG2258	MOSC domain
NHM99_21830	COG0077	Prephenate dehydratase
NHM99_21835	COG0577	efflux transmembrane transporter activity
NHM99_21840	COG0577	efflux transmembrane transporter activity
NHM99_21845	COG1136	(ABC) transporter
NHM99_21850	COG5002	protein histidine kinase activity
NHM99_21855	COG0745	RESPONSE REGULATOR receiver
NHM99_21865	COG3290	protein histidine kinase activity
NHM99_21875	COG2868	ribosomal protein
NHM99_21880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NHM99_21885	COG1530	ribonuclease E activity
NHM99_21890	COG1994	Peptidase M50
NHM99_21895	COG0739	heme binding
NHM99_21900	COG2894	cell division
NHM99_21920	COG1077	Cell shape determining protein MreB Mrl
NHM99_21940	COG0285	dihydrofolate synthase activity
NHM99_21965	COG1388	LysM domain
NHM99_21975	COG0113	porphobilinogen synthase activity
NHM99_21980	COG1587	Uroporphyrinogen-III synthase
NHM99_21990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NHM99_22000	COG1846	Transcriptional regulator
NHM99_22005	COG1764	response to oxidative stress
NHM99_22020	COG0470	DNA polymerase III
NHM99_22020	COG1067	ATP-dependent peptidase activity
NHM99_22075	COG0622	Phosphoesterase
NHM99_22090	COG5401	PFAM Sporulation and spore germination
NHM99_22110	COG1309	transcriptional regulator
NHM99_22125	COG2197	response regulator
NHM99_22130	COG2233	PERMEase
NHM99_22135	COG0402	S-adenosylhomocysteine deaminase activity
NHM99_22140	COG1983	PspC domain protein
NHM99_22145	COG1396	sequence-specific DNA binding
NHM99_22150	COG0697	spore germination
NHM99_22160	COG1959	2 iron, 2 sulfur cluster binding
NHM99_22165	COG1668	transmembrane transport
NHM99_22170	COG4152	abc transporter atp-binding protein
NHM99_22175	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
NHM99_22180	COG1360	Flagellar Motor Protein
NHM99_22185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NHM99_22190	COG1876	peptidase activity
NHM99_22195	COG0824	Thioesterase
NHM99_22200	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NHM99_22205	COG1053	succinate dehydrogenase
NHM99_22210	COG2009	succinate dehydrogenase
NHM99_22215	COG1719	4-vinyl reductase, 4VR
NHM99_22225	COG3118	belongs to the thioredoxin family
NHM99_22230	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NHM99_22235	COG2086	electron transfer activity
NHM99_22240	COG1024	Enoyl-CoA hydratase
NHM99_22245	COG1309	transcriptional regulator
NHM99_22250	COG0318	PFAM AMP-dependent synthetase and ligase
NHM99_22260	COG2318	DinB family
NHM99_22285	COG1131	(ABC) transporter
NHM99_22295	COG0745	RESPONSE REGULATOR receiver
NHM99_22305	COG4895	conserved protein (DUF2196)
NHM99_22310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NHM99_22325	COG4509	Sortase family
NHM99_22330	COG1120	ATPase activity
NHM99_22345	COG5386	Cell surface protein
NHM99_22350	COG5386	Cell surface protein
NHM99_22355	COG1114	Component of the transport system for branched-chain amino acids
NHM99_22360	COG1187	pseudouridine synthase activity
NHM99_22370	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NHM99_22370	COG1796	DNA polymerase
NHM99_22375	COG1286	toxin biosynthetic process
NHM99_22420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NHM99_22430	COG1418	mRNA catabolic process
NHM99_22440	COG2814	Major facilitator Superfamily
NHM99_22445	COG1566	PFAM secretion protein HlyD family protein
NHM99_22450	COG1309	transcriptional regulator
NHM99_22455	COG1363	Peptidase, m42
NHM99_22480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NHM99_22490	COG1484	DNA-dependent DNA replication
NHM99_22495	COG3611	Membrane attachment protein
NHM99_22505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NHM99_22510	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NHM99_22515	COG0237	dephospho-CoA kinase activity
NHM99_22530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHM99_22530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NHM99_22535	COG5002	protein histidine kinase activity
NHM99_22540	COG0745	RESPONSE REGULATOR receiver
NHM99_22560	COG0538	isocitrate dehydrogenase activity
NHM99_22565	COG0372	Belongs to the citrate synthase family
NHM99_22580	COG3030	protein affecting phage T7 exclusion by the F plasmid
NHM99_22605	COG1725	Transcriptional regulator
NHM99_22610	COG0281	malic enzyme
NHM99_22615	COG0587	DNA-directed DNA polymerase activity
NHM99_22630	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NHM99_22670	COG0006	proline dipeptidase activity
NHM99_22705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_22710	COG0662	Cupin 2, conserved barrel domain protein
NHM99_22725	COG1028	Short-chain dehydrogenase reductase Sdr
NHM99_22730	COG0589	response to stress
NHM99_22800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_22825	COG0827	DNA restriction-modification system
NHM99_22830	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NHM99_22835	COG3874	Sporulation protein YtfJ
NHM99_22850	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NHM99_22860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHM99_22875	COG1104	cysteine desulfurase activity
NHM99_22885	COG0583	DNA-binding transcription factor activity
NHM99_22890	COG0697	spore germination
NHM99_22895	COG1309	transcriptional regulator
NHM99_22900	COG1956	GAF domain-containing protein
NHM99_22905	COG0626	cystathionine gamma-synthase activity
NHM99_22935	COG1595	DNA-templated transcription, initiation
NHM99_22950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NHM99_22955	COG0454	-acetyltransferase
NHM99_22960	COG0517	IMP dehydrogenase activity
NHM99_22965	COG0123	including yeast histone deacetylase and acetoin utilization protein
NHM99_22980	COG0745	RESPONSE REGULATOR receiver
NHM99_23020	COG1609	Transcriptional regulator
NHM99_23025	COG4851	CamS sex pheromone cAM373 precursor
NHM99_23030	COG3118	belongs to the thioredoxin family
NHM99_23040	COG2309	aminopeptidase activity
NHM99_23060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_23075	COG1674	ftsk spoiiie
NHM99_23085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NHM99_23095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHM99_23100	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
NHM99_23105	COG1363	Peptidase, m42
NHM99_23115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_23130	COG0510	thiamine kinase activity
NHM99_23135	COG1523	belongs to the glycosyl hydrolase 13 family
NHM99_23145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NHM99_23150	COG1349	DNA-binding transcription factor activity
NHM99_23155	COG1187	pseudouridine synthase activity
NHM99_23165	COG2081	HI0933 family
NHM99_23170	COG2814	Major facilitator Superfamily
NHM99_23180	COG3832	glyoxalase III activity
NHM99_23200	COG1329	Transcriptional regulator
NHM99_23225	COG0314	molybdopterin synthase activity
NHM99_23230	COG1763	Mo-molybdopterin cofactor biosynthetic process
NHM99_23235	COG0303	'Molybdopterin
NHM99_23245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NHM99_23250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NHM99_23270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NHM99_23280	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NHM99_23320	COG2814	Major facilitator Superfamily
NHM99_23325	COG0475	glutathione-regulated potassium exporter activity
NHM99_23330	COG0490	domain, Protein
NHM99_23335	COG0582	viral genome integration into host DNA
NHM99_23345	COG1136	(ABC) transporter
NHM99_23365	COG1242	4 iron, 4 sulfur cluster binding
NHM99_23370	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NHM99_23385	COG1794	racemase activity, acting on amino acids and derivatives
NHM99_23410	COG2267	carboxylic ester hydrolase activity
NHM99_23415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NHM99_23420	COG0671	phosphoesterase, PA-phosphatase related
NHM99_23425	COG0438	transferase activity, transferring glycosyl groups
NHM99_23435	COG0521	Mo-molybdopterin cofactor biosynthetic process
NHM99_23450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_23495	COG5002	protein histidine kinase activity
NHM99_23500	COG4191	Histidine kinase
NHM99_23505	COG2267	carboxylic ester hydrolase activity
NHM99_23510	COG1368	sulfuric ester hydrolase activity
NHM99_23530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NHM99_23535	COG1116	anion transmembrane transporter activity
NHM99_23540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NHM99_23565	COG0494	nUDIX hydrolase
NHM99_23600	COG0288	reversible hydration of carbon dioxide
NHM99_23605	COG1271	oxidase subunit
NHM99_23610	COG1294	oxidase, subunit
NHM99_23630	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_23655	COG1842	Phage shock protein A
NHM99_23690	COG5002	protein histidine kinase activity
NHM99_23695	COG0745	RESPONSE REGULATOR receiver
NHM99_23725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NHM99_23730	COG1597	lipid kinase activity
NHM99_23750	COG0577	efflux transmembrane transporter activity
NHM99_23755	COG1136	(ABC) transporter
NHM99_23770	COG0586	Pfam SNARE associated Golgi protein
NHM99_23780	COG4977	sequence-specific DNA binding
NHM99_23790	COG0577	efflux transmembrane transporter activity
NHM99_23795	COG1136	(ABC) transporter
NHM99_23800	COG2207	Transcriptional regulator
NHM99_23800	COG3708	Transcriptional regulator
NHM99_23805	COG5658	integral membrane protein
NHM99_23810	COG0640	Transcriptional regulator
NHM99_23815	COG0745	RESPONSE REGULATOR receiver
NHM99_23820	COG2205	protein histidine kinase activity
NHM99_23825	COG0577	efflux transmembrane transporter activity
NHM99_23830	COG0577	efflux transmembrane transporter activity
NHM99_23835	COG1136	(ABC) transporter
NHM99_23855	COG2188	Transcriptional regulator
NHM99_23875	COG3964	amidohydrolase
NHM99_23895	COG4948	Mandelate Racemase Muconate Lactonizing
NHM99_23910	COG0596	Alpha beta hydrolase
NHM99_23920	COG1169	isochorismate synthase
NHM99_23925	COG1575	Belongs to the MenA family. Type 1 subfamily
NHM99_23930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NHM99_23955	COG0058	SHG alpha-glucan phosphorylase activity
NHM99_23965	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NHM99_23985	COG1404	Belongs to the peptidase S8 family
NHM99_24085	COG0544	peptidyl-prolyl cis-trans isomerase activity
NHM99_24120	COG1285	pathogenesis
NHM99_24125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NHM99_24140	COG2155	Conserved Protein
NHM99_24145	COG1098	S1 RNA binding domain
NHM99_24150	COG0436	Aminotransferase
NHM99_24155	COG1522	sequence-specific DNA binding
NHM99_24160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NHM99_24165	COG2267	carboxylic ester hydrolase activity
NHM99_24175	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NHM99_24195	COG5018	Exonuclease
NHM99_24200	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NHM99_24220	COG2050	protein possibly involved in aromatic compounds catabolism
NHM99_24230	COG1268	BioY protein
NHM99_24240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NHM99_24245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NHM99_24260	COG3584	3D domain protein
NHM99_24275	COG1252	NADH dehydrogenase
NHM99_24285	COG3708	Transcriptional regulator
NHM99_24300	COG1683	Conserved Protein
NHM99_24315	COG0316	Belongs to the HesB IscA family
NHM99_24330	COG1252	NADH dehydrogenase
NHM99_24340	COG2274	protein secretion by the type I secretion system
NHM99_24345	COG0390	transport system, permease component
NHM99_24350	COG2824	Alkylphosphonate utilization operon protein PhnA
NHM99_24390	COG4837	Protein of unknown function (DUF1462)
NHM99_24395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NHM99_24405	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NHM99_24410	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NHM99_24420	COG2249	NAD(P)H dehydrogenase (quinone) activity
NHM99_24425	COG0647	UMP catabolic process
NHM99_24435	COG2445	Protein of unknown function DUF86
NHM99_24440	COG1494	fructose-1,6-bisphosphatase
NHM99_24455	COG4470	Protein conserved in bacteria
NHM99_24465	COG0789	Transcriptional regulator
NHM99_24470	COG4377	Putative membrane peptidase family (DUF2324)
NHM99_24495	COG0739	heme binding
NHM99_24505	COG3377	Domain of unknown function (DUF1805)
NHM99_24510	COG0737	Belongs to the 5'-nucleotidase family
NHM99_24515	COG0719	Fe-S assembly protein
NHM99_24520	COG0822	iron-sulfur transferase activity
NHM99_24525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NHM99_24530	COG0719	Fe-S assembly protein
NHM99_24535	COG0396	ATPase activity
NHM99_24540	COG1464	Belongs to the NlpA lipoprotein family
NHM99_24545	COG1464	Belongs to the NlpA lipoprotein family
NHM99_24550	COG2011	ABC-type metal ion transport system permease component
NHM99_24555	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NHM99_24565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NHM99_24570	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NHM99_24580	COG1393	Belongs to the ArsC family
NHM99_24635	COG1396	sequence-specific DNA binding
NHM99_24645	COG1309	transcriptional regulator
NHM99_24650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NHM99_24655	COG1960	acyl-CoA dehydrogenase activity
NHM99_24665	COG0183	Belongs to the thiolase family
NHM99_24670	COG1024	Enoyl-CoA hydratase
NHM99_24670	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHM99_24680	COG1686	Belongs to the peptidase S11 family
NHM99_24695	COG0011	TIGRFAM Protein of
NHM99_24700	COG0840	transmembrane signaling receptor activity
NHM99_24725	COG2814	Major facilitator Superfamily
NHM99_24730	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NHM99_24740	COG0531	amino acid
NHM99_24775	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NHM99_24810	COG0586	Pfam SNARE associated Golgi protein
NHM99_24820	COG1376	ErfK ybiS ycfS ynhG family protein
NHM99_24825	COG0745	RESPONSE REGULATOR receiver
NHM99_24830	COG5002	protein histidine kinase activity
NHM99_24860	COG0840	transmembrane signaling receptor activity
NHM99_24865	COG2151	metal-sulfur cluster biosynthetic enzyme
NHM99_24870	COG3227	Zinc metalloprotease (Elastase)
NHM99_24875	COG1741	Belongs to the pirin family
NHM99_24890	COG0475	glutathione-regulated potassium exporter activity
NHM99_24895	COG0490	domain, Protein
NHM99_24905	COG0783	Belongs to the Dps family
NHM99_24925	COG1611	Belongs to the LOG family
NHM99_24945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHM99_24950	COG1115	amino acid carrier protein
NHM99_24955	COG1115	amino acid carrier protein
NHM99_24960	COG2910	NAD(P)H-binding
NHM99_24980	COG0656	L-ascorbic acid biosynthetic process
NHM99_24985	COG2814	Major facilitator Superfamily
NHM99_24990	COG1733	regulation of RNA biosynthetic process
NHM99_25000	COG1252	NADH dehydrogenase
NHM99_25005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NHM99_25035	COG3290	protein histidine kinase activity
NHM99_25035	COG0840	transmembrane signaling receptor activity
NHM99_25045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NHM99_25070	COG0488	(ABC) transporter
NHM99_25075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NHM99_25120	COG1136	(ABC) transporter
NHM99_25140	COG0586	Pfam SNARE associated Golgi protein
NHM99_25145	COG3963	phosphatidate phosphatase activity
NHM99_25195	COG2207	Transcriptional regulator
NHM99_25195	COG3708	Transcriptional regulator
NHM99_25210	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NHM99_25215	COG2814	Major facilitator Superfamily
NHM99_25225	COG0640	Transcriptional regulator
NHM99_25230	COG2311	Membrane
NHM99_25250	COG0557	exoribonuclease II activity
NHM99_25255	COG1647	Serine aminopeptidase, S33
NHM99_25260	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NHM99_25265	COG1346	cytolysis
NHM99_25300	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NHM99_25315	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NHM99_25350	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NHM99_25380	COG4974	Belongs to the 'phage' integrase family
NHM99_25400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NHM99_25415	COG2323	membrane
NHM99_25425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NHM99_25435	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NHM99_25445	COG1051	belongs to the nudix hydrolase family
NHM99_25455	COG0492	ferredoxin-NADP+ reductase activity
NHM99_25460	COG0457	Tetratricopeptide repeat
NHM99_25465	COG0110	maltose O-acetyltransferase activity
NHM99_25485	COG1950	PFAM Membrane protein of
NHM99_25495	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NHM99_25510	COG0789	Transcriptional regulator
NHM99_25545	COG0583	DNA-binding transcription factor activity
NHM99_25555	COG0655	NAD(P)H dehydrogenase (quinone) activity
NHM99_25570	COG1132	(ABC) transporter
NHM99_25575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHM99_25580	COG0793	Belongs to the peptidase S41A family
NHM99_25580	COG3409	Peptidoglycan-binding domain 1 protein
NHM99_25585	COG2177	Part of the ABC transporter FtsEX involved in
NHM99_25610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NHM99_25615	COG1278	Cold shock
NHM99_25620	COG1040	competence protein
NHM99_25625	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NHM99_25630	COG0791	NLP P60 protein
NHM99_25630	COG1388	LysM domain
NHM99_25635	COG1733	regulation of RNA biosynthetic process
NHM99_25640	COG1307	EDD domain protein, DegV family
NHM99_25645	COG1739	Uncharacterized protein family UPF0029
NHM99_25650	COG1316	TRANSCRIPTIONal
NHM99_25655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NHM99_25660	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NHM99_25665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NHM99_25675	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NHM99_25675	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NHM99_25695	COG1486	melibiose metabolic process
NHM99_25700	COG1447	Phosphotransferase system cellobiose-specific component IIA
NHM99_25705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NHM99_25715	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NHM99_25735	COG1447	Phosphotransferase system cellobiose-specific component IIA
NHM99_25745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NHM99_25750	COG1301	dicarboxylic acid transport
NHM99_25760	COG0346	lactoylglutathione lyase activity
NHM99_25785	COG0583	DNA-binding transcription factor activity
NHM99_25790	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NHM99_25805	COG1294	oxidase, subunit
NHM99_25810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NHM99_25820	COG1620	l-lactate permease
NHM99_25830	COG2389	metal-binding protein
NHM99_25840	COG1368	sulfuric ester hydrolase activity
NHM99_25850	COG0791	NLP P60 protein
NHM99_25850	COG1388	LysM domain
NHM99_25855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NHM99_25870	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NHM99_25875	COG1388	LysM domain
NHM99_25875	COG3584	3D domain protein
NHM99_25900	COG4715	Zinc finger, swim domain protein
NHM99_25905	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NHM99_25945	COG0577	efflux transmembrane transporter activity
NHM99_25950	COG1136	(ABC) transporter
NHM99_25975	COG3850	Histidine kinase
NHM99_25975	COG5002	protein histidine kinase activity
NHM99_25980	COG0745	RESPONSE REGULATOR receiver
NHM99_25985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NHM99_25995	COG1316	TRANSCRIPTIONal
NHM99_26000	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NHM99_26005	COG1216	Glycosyl transferase, family 2
NHM99_26015	COG0438	transferase activity, transferring glycosyl groups
NHM99_26035	COG1086	Polysaccharide biosynthesis protein
NHM99_26055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NHM99_26060	COG1086	Polysaccharide biosynthesis protein
NHM99_26065	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NHM99_26075	COG0489	protein tyrosine kinase activity
NHM99_26080	COG3944	biosynthesis protein
NHM99_26085	COG0489	protein tyrosine kinase activity
NHM99_26100	COG1609	Transcriptional regulator
NHM99_26110	COG0739	heme binding
NHM99_26125	COG3279	Response regulator of the LytR AlgR family
NHM99_26130	COG2385	sporulation resulting in formation of a cellular spore
NHM99_26145	COG4836	Membrane
NHM99_26150	COG1007	ATP synthesis coupled electron transport
NHM99_26155	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHM99_26160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NHM99_26190	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NHM99_26205	COG3300	MHYT domain
NHM99_26205	COG5001	Diguanylate cyclase
NHM99_26255	COG0356	it plays a direct role in the translocation of protons across the membrane
NHM99_26290	COG0698	ribose 5-phosphate isomerase
NHM99_26300	COG2190	(PTS) system
NHM99_26305	COG2259	Doxx family
NHM99_26310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NHM99_26325	COG0009	L-threonylcarbamoyladenylate synthase
NHM99_26340	COG2890	protein-(glutamine-N5) methyltransferase activity
NHM99_26360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NHM99_26365	COG1494	fructose-1,6-bisphosphatase
NHM99_26385	COG4821	SIS domain
NHM99_26405	COG1960	acyl-CoA dehydrogenase activity
NHM99_26410	COG1960	acyl-CoA dehydrogenase activity
NHM99_26415	COG1250	3-hydroxyacyl-CoA dehydrogenase
NHM99_26420	COG0183	Belongs to the thiolase family
NHM99_26425	COG0247	lactate metabolic process
NHM99_26425	COG2181	nitrate reductase activity
NHM99_26430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NHM99_26440	COG5001	Diguanylate cyclase
NHM99_26440	COG3300	MHYT domain
NHM99_26460	COG2197	response regulator
NHM99_26465	COG4585	Histidine kinase
NHM99_26475	COG1131	(ABC) transporter
NHM99_26480	COG0024	Methionine aminopeptidase
NHM99_26490	COG2234	aminopeptidase activity
NHM99_26510	COG1595	DNA-templated transcription, initiation
NHM99_26520	COG4506	Protein conserved in bacteria
NHM99_26525	COG1619	proteins homologs of microcin C7 resistance protein MccF
NHM99_26550	COG2814	Major facilitator Superfamily
NHM99_26555	COG0789	Transcriptional regulator
NHM99_26560	COG0584	glycerophosphoryl diester phosphodiesterase
NHM99_26565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NHM99_26575	COG1994	Peptidase M50
NHM99_26585	COG1078	dGTPase activity
NHM99_26590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NHM99_26595	COG1120	ATPase activity
NHM99_26600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_26605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NHM99_26625	COG0095	Lipoate-protein ligase
NHM99_26630	COG0280	phosphate acetyltransferase
NHM99_26645	COG3773	Cell wall hydrolase
NHM99_26655	COG2363	Small membrane protein
NHM99_26665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NHM99_26670	COG2233	PERMEase
NHM99_26675	COG0561	phosphatase activity
NHM99_26680	COG2814	Major facilitator Superfamily
NHM99_26690	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NHM99_26695	COG1131	(ABC) transporter
NHM99_26700	COG2755	lipolytic protein G-D-S-L family
NHM99_26705	COG1609	Transcriptional regulator
NHM99_26715	COG0460	homoserine dehydrogenase
NHM99_26725	COG2873	o-acetylhomoserine
NHM99_26740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NHM99_26750	COG2197	response regulator
NHM99_26760	COG0351	phosphomethylpyrimidine kinase
NHM99_26765	COG3706	GGDEF domain
NHM99_26770	COG2879	small protein
NHM99_26775	COG1966	Carbon starvation protein
NHM99_26780	COG3279	Response regulator of the LytR AlgR family
NHM99_26785	COG0477	Major facilitator Superfamily
NHM99_26795	COG0438	transferase activity, transferring glycosyl groups
NHM99_26810	COG0840	transmembrane signaling receptor activity
NHM99_26820	COG1607	acyl-coa hydrolase
NHM99_26825	COG1216	Glycosyl transferase, family 2
NHM99_26840	COG1216	Glycosyl transferase, family 2
NHM99_26855	COG0488	(ABC) transporter
NHM99_26860	COG1309	transcriptional regulator
NHM99_26865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NHM99_26870	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHM99_26870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NHM99_26875	COG0628	permease
NHM99_26890	COG3279	Response regulator of the LytR AlgR family
NHM99_26895	COG3275	phosphorelay sensor kinase activity
NHM99_26900	COG2814	Major facilitator Superfamily
NHM99_26905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NHM99_26910	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NHM99_26915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NHM99_26960	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NHM99_26965	COG1272	protein, Hemolysin III
NHM99_26985	COG1164	Oligoendopeptidase f
NHM99_27005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NHM99_27010	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NHM99_27015	COG4853	Protein conserved in bacteria
NHM99_27020	COG4863	YycH protein
NHM99_27025	COG5002	protein histidine kinase activity
NHM99_27030	COG0745	RESPONSE REGULATOR receiver
NHM99_27060	COG0305	Participates in initiation and elongation during chromosome replication
NHM99_27070	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NHM99_27075	COG4241	membrane
NHM99_27085	COG0629	single-stranded DNA binding
NHM99_27095	COG0012	GTP binding
NHM99_27100	COG4481	Protein conserved in bacteria
NHM99_27105	COG0668	transmembrane transport
NHM99_27115	COG1475	DNA binding
NHM99_27120	COG1192	Involved in chromosome partitioning
NHM99_27145	COG1847	R3H domain protein
NHM99_27150	COG0706	membrane insertase activity
NHM99_27160	COG0230	Belongs to the bacterial ribosomal protein bL34 family