locus-tag	class	description
fado_126	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
fado_145	COG3420	alginic acid biosynthetic process
fado_145	COG5434	Belongs to the glycosyl hydrolase 28 family
fado_162	COG0582	viral genome integration into host DNA
fado_163	COG0739	heme binding
fado_163	COG0741	lytic transglycosylase activity
fado_163	COG1196	nuclear chromosome segregation
fado_166	COG2433	Pfam Transposase IS66
fado_171	COG1388	LysM domain
fado_171	COG1705	Flagellar rod assembly protein muramidase FlgJ
fado_181	COG1435	thymidine kinase activity
fado_183	COG0740	serine-type endopeptidase activity
fado_184	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
fado_194	COG1192	Involved in chromosome partitioning
fado_203	COG1404	Belongs to the peptidase S8 family
fado_210	COG0756	dUTP diphosphatase activity
fado_211	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
fado_212	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
fado_214	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
fado_217	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
fado_218	COG0187	DNA topoisomerase II activity
fado_29	COG4195	phage-related replication protein
fado_30	COG0754	glutathionylspermidine amidase activity
fado_39	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
fado_39	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
fado_46	COG3583	domain protein
fado_46	COG3584	3D domain protein
fado_78	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
fado_81	COG1216	Glycosyl transferase, family 2
fado_83	COG2195	Cleaves the N-terminal amino acid of tripeptides
fado_87	COG0457	Tetratricopeptide repeat