locus-tag	class	description
Kirov_100	COG1404	Belongs to the peptidase S8 family
Kirov_11	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Kirov_115	COG0194	GDP metabolic process
Kirov_124	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Kirov_125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Kirov_127	COG1780	Probably involved in ribonucleotide reductase function
Kirov_130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Kirov_131	COG0187	DNA topoisomerase II activity
Kirov_152	COG0322	excinuclease ABC activity
Kirov_16	COG0739	heme binding
Kirov_164	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Kirov_170	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Kirov_171	COG3584	3D domain protein
Kirov_171	COG3583	domain protein
Kirov_210	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Kirov_27	COG0776	regulation of translation
Kirov_28	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Kirov_46	COG4974	Belongs to the 'phage' integrase family
Kirov_47	COG0741	lytic transglycosylase activity
Kirov_47	COG1196	nuclear chromosome segregation
Kirov_47	COG0741	lytic transglycosylase activity
Kirov_47	COG0739	heme binding
Kirov_47	COG1196	nuclear chromosome segregation
Kirov_47	COG0739	heme binding
Kirov_50	COG2433	Pfam Transposase IS66
Kirov_56	COG3409	Peptidoglycan-binding domain 1 protein
Kirov_56	COG5632	N-Acetylmuramoyl-L-alanine amidase
Kirov_56	COG1388	LysM domain
Kirov_67	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Kirov_69	COG0587	DNA-directed DNA polymerase activity
Kirov_71	COG1435	thymidine kinase activity
Kirov_78	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Kirov_90	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Kirov_96	COG0740	serine-type endopeptidase activity