locus-tag	class	description
PBC4_017	COG0739	heme binding
PBC4_017	COG0741	lytic transglycosylase activity
PBC4_017	COG1196	nuclear chromosome segregation
PBC4_030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PBC4_033	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PBC4_042	COG0358	DNA primase activity
PBC4_043	COG0305	Participates in initiation and elongation during chromosome replication
PBC4_052	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PBC4_056	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PBC4_057	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PBC4_066	COG3646	Phage regulatory protein
PBC4_072	COG4974	Belongs to the 'phage' integrase family