locus-tag	class	description
spr_1	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
spr_108	COG1573	uracil-dna glycosylase
spr_115	COG0582	viral genome integration into host DNA
spr_118	COG3655	Transcriptional regulator
spr_136	COG1793	dna ligase
spr_137	COG2135	peptidase activity
spr_147	COG2887	Belongs to the helicase family. UvrD subfamily
spr_149	COG0305	Participates in initiation and elongation during chromosome replication
spr_150	COG0358	DNA primase activity
spr_151	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
spr_152	COG0587	DNA-directed DNA polymerase activity
spr_153	COG3584	3D domain protein
spr_158	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
spr_161	COG0270	DNA (cytosine-5-)-methyltransferase activity
spr_181	COG1780	Probably involved in ribonucleotide reductase function
spr_182	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spr_182	COG1372	Participates in initiation and elongation during chromosome replication
spr_183	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spr_184	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spr_186	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
spr_187	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spr_189	COG0756	dUTP diphosphatase activity
spr_19	COG3331	DNA recombination
spr_2	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
spr_21	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
spr_23	COG1525	nuclease
spr_25	COG4282	regulation of fungal-type cell wall biogenesis
spr_26	COG5444	nuclease activity
spr_30	COG0457	Tetratricopeptide repeat
spr_36	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
spr_39	COG2274	protein secretion by the type I secretion system
spr_39	COG3271	cysteine-type peptidase activity
spr_40	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
spr_41	COG0463	Glycosyl transferase, family 2
spr_42	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
spr_45	COG5632	N-Acetylmuramoyl-L-alanine amidase
spr_45	COG3409	Peptidoglycan-binding domain 1 protein
spr_46	COG5434	Belongs to the glycosyl hydrolase 28 family
spr_48	COG2433	Pfam Transposase IS66
spr_50	COG0739	heme binding
spr_50	COG0741	lytic transglycosylase activity
spr_50	COG1196	nuclear chromosome segregation
spr_54	COG0582	viral genome integration into host DNA
spr_57	COG0584	glycerophosphoryl diester phosphodiesterase
spr_83	COG0776	regulation of translation
spr_9	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
spr_97	COG3655	Transcriptional regulator