SMUDGE_178 4587cce6c54e4017c07e097b56fe74fe 97 Pfam PF04688 SPP1 phage holin 16 88 3.9E-13 T 30-10-2018 IPR006479 Holin SMUDGE_178 4587cce6c54e4017c07e097b56fe74fe 97 ProDom PD008023 HOLIN TRANSMEMBRANE MEMBRANE PROPHAGE FAMILY BHLB SPP1 5'REGION HOLIN ORF050 19 84 2.0E-4 T 30-10-2018 IPR006479 Holin SMUDGE_71 ae2db6438acdf5215f4f8744f2a5d292 599 Gene3D G3DSA:3.40.50.300 47 231 1.3E-11 T 30-10-2018 SMUDGE_71 ae2db6438acdf5215f4f8744f2a5d292 599 Pfam PF05876 Phage terminase large subunit (GpA) 63 427 1.4E-26 T 30-10-2018 IPR008866 Bacteriophage lambda, GpA SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 PRINTS PR01183 Ribonucleotide reductase large chain signature 321 340 2.3E-19 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 PRINTS PR01183 Ribonucleotide reductase large chain signature 526 549 2.3E-19 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 PRINTS PR01183 Ribonucleotide reductase large chain signature 472 483 2.3E-19 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 PRINTS PR01183 Ribonucleotide reductase large chain signature 652 679 2.3E-19 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 PRINTS PR01183 Ribonucleotide reductase large chain signature 564 586 2.3E-19 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 SUPERFAMILY SSF51998 245 772 7.63E-116 T 30-10-2018 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 Pfam PF00317 Ribonucleotide reductase, all-alpha domain 166 243 1.2E-7 T 30-10-2018 IPR013509 Ribonucleotide reductase large subunit, N-terminal GO:0004748|GO:0005524|GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 Gene3D G3DSA:3.20.70.20 231 768 1.7E-152 T 30-10-2018 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 TIGRFAM TIGR02506 NrdE_NrdA: ribonucleoside-diphosphate reductase, alpha subunit 169 770 2.0E-120 T 30-10-2018 IPR013346 Ribonucleotide reductase, class I , alpha subunit GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 Pfam PF02867 Ribonucleotide reductase, barrel domain 246 767 1.1E-99 T 30-10-2018 IPR000788 Ribonucleotide reductase large subunit, C-terminal GO:0006260|GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 Gene3D G3DSA:1.10.1650.20 364 434 1.7E-152 T 30-10-2018 SMUDGE_132 0c417cce37635c290e23ccfc355093eb 784 SUPERFAMILY SSF48168 36 243 1.22E-31 T 30-10-2018 IPR008926 Ribonucleotide reductase R1 subunit, N-terminal KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_124 3be4240759bf4a3e69761978d59f3a01 358 SUPERFAMILY SSF57783 8 77 1.55E-11 T 30-10-2018 SMUDGE_124 3be4240759bf4a3e69761978d59f3a01 358 Pfam PF12760 Transposase zinc-ribbon domain 21 51 9.1E-7 T 30-10-2018 IPR024442 Transposase, zinc-ribbon SMUDGE_124 3be4240759bf4a3e69761978d59f3a01 358 Gene3D G3DSA:3.40.1360.10 230 346 1.7E-6 T 30-10-2018 SMUDGE_124 3be4240759bf4a3e69761978d59f3a01 358 Gene3D G3DSA:3.90.580.10 2 82 2.6E-8 T 30-10-2018 IPR036977 DNA Primase, CHC2-type zinc finger GO:0003677|GO:0006260|GO:0008270 SMUDGE_124 3be4240759bf4a3e69761978d59f3a01 358 SUPERFAMILY SSF56731 140 344 2.09E-12 T 30-10-2018 SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 Gene3D G3DSA:3.40.50.300 403 589 1.4E-33 T 30-10-2018 SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 Gene3D G3DSA:3.40.50.300 100 233 2.8E-9 T 30-10-2018 SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 Gene3D G3DSA:3.40.50.300 277 387 3.4E-9 T 30-10-2018 SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 Pfam PF00271 Helicase conserved C-terminal domain 454 545 5.6E-14 T 30-10-2018 IPR001650 Helicase, C-terminal SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 SUPERFAMILY SSF52540 321 559 1.17E-24 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 Pfam PF04851 Type III restriction enzyme, res subunit 129 366 4.0E-10 T 30-10-2018 IPR006935 Helicase/UvrB, N-terminal GO:0003677|GO:0005524|GO:0016787 SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 SUPERFAMILY SSF52540 25 384 9.31E-17 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_112 9c76361d9beb75ce47bf44dfce236773 589 SMART SM00490 465 546 2.6E-16 T 30-10-2018 IPR001650 Helicase, C-terminal SMUDGE_154 cdaae6e7e9d5ba2bbaffecd39451cc50 706 Gene3D G3DSA:3.30.420.10 187 414 6.6E-28 T 30-10-2018 IPR036397 Ribonuclease H superfamily GO:0003676 SMUDGE_154 cdaae6e7e9d5ba2bbaffecd39451cc50 706 SUPERFAMILY SSF52141 31 176 4.25E-5 T 30-10-2018 IPR036895 Uracil-DNA glycosylase-like domain superfamily Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SMUDGE_154 cdaae6e7e9d5ba2bbaffecd39451cc50 706 SUPERFAMILY SSF53098 189 331 1.21E-16 T 30-10-2018 IPR012337 Ribonuclease H-like superfamily SMUDGE_154 cdaae6e7e9d5ba2bbaffecd39451cc50 706 Pfam PF01612 3'-5' exonuclease 201 353 4.3E-12 T 30-10-2018 IPR002562 3'-5' exonuclease domain GO:0003676|GO:0006139|GO:0008408 SMUDGE_154 cdaae6e7e9d5ba2bbaffecd39451cc50 706 Gene3D G3DSA:3.40.470.10 25 179 1.5E-12 T 30-10-2018 IPR036895 Uracil-DNA glycosylase-like domain superfamily Reactome: R-HSA-110328|Reactome: R-HSA-110329|Reactome: R-HSA-110357 SMUDGE_154 cdaae6e7e9d5ba2bbaffecd39451cc50 706 SUPERFAMILY SSF56672 493 704 6.56E-23 T 30-10-2018 SMUDGE_100 1b62a05ced5b99ac86fda76056a5e1dc 725 Gene3D G3DSA:3.90.1720.10 539 718 1.0E-20 T 30-10-2018 SMUDGE_100 1b62a05ced5b99ac86fda76056a5e1dc 725 SUPERFAMILY SSF54001 581 721 5.89E-17 T 30-10-2018 IPR038765 Papain-like cysteine peptidase superfamily SMUDGE_100 1b62a05ced5b99ac86fda76056a5e1dc 725 Pfam PF00877 NlpC/P60 family 597 718 2.1E-16 T 30-10-2018 IPR000064 Endopeptidase, NLPC/P60 domain SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 SMART SM00287 201 267 1.2E-12 T 30-10-2018 IPR003646 SH3-like domain, bacterial-type SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 SMART SM00644 10 151 2.0E-31 T 30-10-2018 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 Reactome: R-HSA-6803157 SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 Pfam PF01510 N-acetylmuramoyl-L-alanine amidase 25 142 1.9E-17 T 30-10-2018 IPR002502 N-acetylmuramoyl-L-alanine amidase domain GO:0008745|GO:0009253 Reactome: R-HSA-6803157 SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 Pfam PF08460 Bacterial SH3 domain 200 255 2.7E-7 T 30-10-2018 IPR003646 SH3-like domain, bacterial-type SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 SUPERFAMILY SSF55846 21 157 8.8E-41 T 30-10-2018 IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily GO:0008745|GO:0009253 Reactome: R-HSA-6803157 SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 Gene3D G3DSA:2.30.30.410 164 277 3.1E-12 T 30-10-2018 SMUDGE_69 b0525a09076f2fbb9a775b1f60b31056 277 Gene3D G3DSA:3.40.80.10 15 163 6.0E-40 T 30-10-2018 IPR036505 N-acetylmuramoyl-L-alanine amidase/PGRP domain superfamily GO:0008745|GO:0009253 Reactome: R-HSA-6803157 SMUDGE_173 30102bd75fb2358075e4e5d7ad9b368d 415 SUPERFAMILY SSF52540 40 291 8.65E-25 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_173 30102bd75fb2358075e4e5d7ad9b368d 415 Pfam PF00154 recA bacterial DNA recombination protein 52 291 7.4E-30 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SMUDGE_173 30102bd75fb2358075e4e5d7ad9b368d 415 PRINTS PR00142 RecA protein signature 99 128 3.7E-7 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SMUDGE_173 30102bd75fb2358075e4e5d7ad9b368d 415 PRINTS PR00142 RecA protein signature 230 258 3.7E-7 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SMUDGE_173 30102bd75fb2358075e4e5d7ad9b368d 415 PRINTS PR00142 RecA protein signature 267 296 3.7E-7 T 30-10-2018 IPR013765 DNA recombination and repair protein RecA GO:0003697|GO:0005524|GO:0006281 SMUDGE_173 30102bd75fb2358075e4e5d7ad9b368d 415 Gene3D G3DSA:3.40.50.300 41 357 1.2E-61 T 30-10-2018 SMUDGE_116 ad92100a0165c83284ed0dfe01b4a6a1 492 SUPERFAMILY SSF52540 172 415 2.87E-25 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_116 ad92100a0165c83284ed0dfe01b4a6a1 492 SMART SM00382 191 414 3.4E-5 T 30-10-2018 IPR003593 AAA+ ATPase domain SMUDGE_116 ad92100a0165c83284ed0dfe01b4a6a1 492 Gene3D G3DSA:3.40.50.300 149 422 3.9E-40 T 30-10-2018 SMUDGE_116 ad92100a0165c83284ed0dfe01b4a6a1 492 Pfam PF03796 DnaB-like helicase C terminal domain 174 361 1.0E-16 T 30-10-2018 IPR007694 DNA helicase, DnaB-like, C-terminal GO:0003678|GO:0005524|GO:0006260 Reactome: R-HSA-2151201 SMUDGE_66 4ef27c78430a39c607660c70ad068fec 136 Gene3D G3DSA:3.40.50.1000 22 132 3.8E-20 T 30-10-2018 IPR023214 HAD superfamily SMUDGE_66 4ef27c78430a39c607660c70ad068fec 136 SUPERFAMILY SSF56784 26 114 5.96E-13 T 30-10-2018 IPR036412 HAD-like superfamily SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 SUPERFAMILY SSF88659 171 233 3.18E-11 T 30-10-2018 IPR013324 RNA polymerase sigma factor, region 3/4-like SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 Pfam PF04545 Sigma-70, region 4 182 231 1.3E-7 T 30-10-2018 IPR007630 RNA polymerase sigma-70 region 4 GO:0003700|GO:0006352|GO:0006355 SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 Gene3D G3DSA:1.20.140.160 111 234 8.8E-14 T 30-10-2018 SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 SUPERFAMILY SSF88946 5 96 2.51E-12 T 30-10-2018 IPR013325 RNA polymerase sigma factor, region 2 GO:0003700|GO:0006352|GO:0006355 SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 Gene3D G3DSA:1.10.1740.10 2 89 7.3E-6 T 30-10-2018 SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 Pfam PF04542 Sigma-70 region 2 22 90 7.1E-8 T 30-10-2018 IPR007627 RNA polymerase sigma-70 region 2 GO:0003700|GO:0006352|GO:0006355 SMUDGE_221 edee66c1375cf6d6562106b72a66e9c7 292 TIGRFAM TIGR02937 sigma70-ECF: RNA polymerase sigma factor, sigma-70 family 17 231 5.1E-16 T 30-10-2018 IPR014284 RNA polymerase sigma-70 like domain GO:0003700|GO:0006352|GO:0006355 SMUDGE_126 bbc5aed2631144dbf6d61e304fcaef39 270 SUPERFAMILY SSF51283 12 105 8.64E-14 T 30-10-2018 IPR036157 dUTPase-like superfamily SMUDGE_126 bbc5aed2631144dbf6d61e304fcaef39 270 SUPERFAMILY SSF51283 217 269 3.27E-8 T 30-10-2018 IPR036157 dUTPase-like superfamily SMUDGE_126 bbc5aed2631144dbf6d61e304fcaef39 270 Pfam PF00692 dUTPase 33 107 7.4E-5 T 30-10-2018 IPR029054 dUTPase-like SMUDGE_107 c2f8f4473888d335411a6f4f321e3d05 250 Gene3D G3DSA:3.10.450.40 126 243 3.1E-11 T 30-10-2018 SMUDGE_107 c2f8f4473888d335411a6f4f321e3d05 250 SUPERFAMILY SSF160719 140 237 9.42E-14 T 30-10-2018 SMUDGE_107 c2f8f4473888d335411a6f4f321e3d05 250 Pfam PF10934 Protein of unknown function (DUF2634) 137 224 1.7E-8 T 30-10-2018 IPR020288 Protein of unknown function DUF2634 SMUDGE_121 2cda014b358aa854a1cfada7cbc90332 629 SUPERFAMILY SSF75712 278 358 2.09E-7 T 30-10-2018 SMUDGE_121 2cda014b358aa854a1cfada7cbc90332 629 Gene3D G3DSA:3.40.50.300 1 246 1.7E-20 T 30-10-2018 SMUDGE_121 2cda014b358aa854a1cfada7cbc90332 629 SUPERFAMILY SSF52540 364 621 5.32E-20 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_121 2cda014b358aa854a1cfada7cbc90332 629 Gene3D G3DSA:3.40.50.300 326 625 7.9E-29 T 30-10-2018 SMUDGE_121 2cda014b358aa854a1cfada7cbc90332 629 SUPERFAMILY SSF52540 1 300 2.52E-9 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_198 8be879e8cf5b02b48d22c95e393f6dd1 100 Gene3D G3DSA:1.10.287.1080 7 100 3.1E-10 T 30-10-2018 SMUDGE_198 8be879e8cf5b02b48d22c95e393f6dd1 100 SUPERFAMILY SSF101386 19 99 2.78E-9 T 30-10-2018 SMUDGE_198 8be879e8cf5b02b48d22c95e393f6dd1 100 Pfam PF03819 MazG nucleotide pyrophosphohydrolase domain 21 98 5.7E-5 T 30-10-2018 IPR004518 NTP pyrophosphohydrolase MazG, putative catalytic core SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 SUPERFAMILY SSF56672 1 215 6.45E-46 T 30-10-2018 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 Gene3D G3DSA:1.10.150.20 1 130 2.7E-33 T 30-10-2018 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 Pfam PF00476 DNA polymerase family A 1 212 6.6E-43 T 30-10-2018 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 PRINTS PR00868 DNA-polymerase family A (pol I) signature 32 57 2.9E-19 T 30-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 PRINTS PR00868 DNA-polymerase family A (pol I) signature 8 21 2.9E-19 T 30-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 PRINTS PR00868 DNA-polymerase family A (pol I) signature 69 80 2.9E-19 T 30-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 PRINTS PR00868 DNA-polymerase family A (pol I) signature 123 139 2.9E-19 T 30-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 PRINTS PR00868 DNA-polymerase family A (pol I) signature 91 102 2.9E-19 T 30-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 PRINTS PR00868 DNA-polymerase family A (pol I) signature 153 166 2.9E-19 T 30-10-2018 IPR002298 DNA polymerase A GO:0003887|GO:0006261 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_156 a11dc462f9880ffe4cba89fe41b6e755 274 SMART SM00482 1 170 1.8E-14 T 30-10-2018 IPR001098 DNA-directed DNA polymerase, family A, palm domain GO:0003677|GO:0003887|GO:0006260 KEGG: 00230+2.7.7.7|KEGG: 00240+2.7.7.7 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 Gene3D G3DSA:3.30.572.10 5 295 1.1E-98 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 TIGRFAM TIGR03284 thym_sym: thymidylate synthase 18 295 2.8E-84 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 SUPERFAMILY SSF55831 5 295 6.8E-95 T 30-10-2018 IPR036926 Thymidylate synthase/dCMP hydroxymethylase superfamily KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 Hamap MF_00008 Thymidylate synthase [thyA]. 13 295 30.531 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 Pfam PF00303 Thymidylate synthase 19 295 5.5E-89 T 30-10-2018 IPR023451 Thymidylate synthase/dCMP hydroxymethylase domain KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 PRINTS PR00108 Thymidylate synthase family signature 171 186 1.4E-32 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 PRINTS PR00108 Thymidylate synthase family signature 190 216 1.4E-32 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 PRINTS PR00108 Thymidylate synthase family signature 145 164 1.4E-32 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 PRINTS PR00108 Thymidylate synthase family signature 54 75 1.4E-32 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_59 a0fd5b0c0215593b7038f04d309c308b 300 PRINTS PR00108 Thymidylate synthase family signature 228 245 1.4E-32 T 30-10-2018 IPR000398 Thymidylate synthase GO:0004799|GO:0006231 KEGG: 00240+2.1.1.45|KEGG: 00670+2.1.1.45|MetaCyc: PWY-3841|MetaCyc: PWY-7184|MetaCyc: PWY-7187|MetaCyc: PWY-7198|MetaCyc: PWY-7199|MetaCyc: PWY-7210|Reactome: R-HSA-499943|Reactome: R-HSA-539107 SMUDGE_82 f04a60ce0cae54d3a4f671731be68c35 563 Pfam PF04860 Phage portal protein 162 462 2.8E-21 T 30-10-2018 IPR006944 Bacteriophage/Gene transfer agent portal protein SMUDGE_184 02240c79905bf899f81ad33584a6111a 425 SUPERFAMILY SSF56300 162 382 2.9E-10 T 30-10-2018 SMUDGE_184 02240c79905bf899f81ad33584a6111a 425 Gene3D G3DSA:3.60.21.10 161 389 1.5E-5 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like SMUDGE_136 d02d169096a7e22bf4113e0e68a7c44d 159 SUPERFAMILY SSF52218 1 121 7.75E-10 T 30-10-2018 IPR029039 Flavoprotein-like superfamily SMUDGE_136 d02d169096a7e22bf4113e0e68a7c44d 159 Gene3D G3DSA:3.40.50.360 1 143 2.8E-10 T 30-10-2018 IPR029039 Flavoprotein-like superfamily SMUDGE_139 f7f5ca79b1f9ea1f39d531c7faaad7e2 92 Gene3D G3DSA:3.40.30.10 1 80 9.9E-7 T 30-10-2018 SMUDGE_139 f7f5ca79b1f9ea1f39d531c7faaad7e2 92 SUPERFAMILY SSF52833 4 69 8.02E-8 T 30-10-2018 IPR036249 Thioredoxin-like superfamily SMUDGE_139 f7f5ca79b1f9ea1f39d531c7faaad7e2 92 Pfam PF00085 Thioredoxin 4 70 7.3E-5 T 30-10-2018 IPR013766 Thioredoxin domain GO:0045454 SMUDGE_110 91afb5d92af6f652983cd4b78ce8dc02 1203 Pfam PF16075 Domain of unknown function (DUF4815) 11 634 4.7E-127 T 30-10-2018 IPR032096 Domain of unknown function DUF4815 SMUDGE_67 9fd2811d80912b341a42ef9ba4570c33 495 Gene3D G3DSA:3.20.20.70 150 429 6.0E-90 T 30-10-2018 IPR013785 Aldolase-type TIM barrel GO:0003824 SMUDGE_67 9fd2811d80912b341a42ef9ba4570c33 495 PIRSF PIRSF005943 1 495 9.4E-157 T 30-10-2018 IPR016471 Nicotinamide phosphoribosyl transferase Reactome: R-HSA-1368108|Reactome: R-HSA-197264 SMUDGE_67 9fd2811d80912b341a42ef9ba4570c33 495 Pfam PF04095 Nicotinate phosphoribosyltransferase (NAPRTase) family 186 475 7.0E-43 T 30-10-2018 IPR007229 Nicotinate phosphoribosyltransferase family KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381|Reactome: R-HSA-197264 SMUDGE_67 9fd2811d80912b341a42ef9ba4570c33 495 SUPERFAMILY SSF51690 184 492 2.32E-32 T 30-10-2018 IPR036068 Nicotinate phosphoribosyltransferase-like, C-terminal GO:0004514|GO:0009435 KEGG: 00760+6.3.4.21|MetaCyc: PWY-5381 SMUDGE_96 efa2d4046dab8e9e565bfec13fbdd94f 240 Gene3D G3DSA:2.40.40.10 119 222 3.2E-6 T 30-10-2018 IPR036908 RlpA-like domain superfamily SMUDGE_96 efa2d4046dab8e9e565bfec13fbdd94f 240 Pfam PF06725 3D domain 179 240 4.5E-21 T 30-10-2018 IPR010611 3D domain GO:0004553|GO:0009254|GO:0019867 SMUDGE_96 efa2d4046dab8e9e565bfec13fbdd94f 240 SUPERFAMILY SSF50685 172 220 1.6E-8 T 30-10-2018 IPR036908 RlpA-like domain superfamily SMUDGE_56 6664b9f6c64f8f794c5d005e6a04c713 219 SUPERFAMILY SSF52540 18 212 2.52E-13 T 30-10-2018 IPR027417 P-loop containing nucleoside triphosphate hydrolase SMUDGE_56 6664b9f6c64f8f794c5d005e6a04c713 219 Pfam PF13238 AAA domain 19 180 1.4E-11 T 30-10-2018 SMUDGE_56 6664b9f6c64f8f794c5d005e6a04c713 219 Gene3D G3DSA:3.40.50.300 19 214 1.5E-25 T 30-10-2018 SMUDGE_53 cf6588b56edd9843930f8da3ee43c097 166 PRINTS PR00070 Dihydrofolate reductase signature 41 52 2.3E-7 T 30-10-2018 SMUDGE_53 cf6588b56edd9843930f8da3ee43c097 166 PRINTS PR00070 Dihydrofolate reductase signature 94 108 2.3E-7 T 30-10-2018 SMUDGE_53 cf6588b56edd9843930f8da3ee43c097 166 PRINTS PR00070 Dihydrofolate reductase signature 28 36 2.3E-7 T 30-10-2018 SMUDGE_53 cf6588b56edd9843930f8da3ee43c097 166 Pfam PF00186 Dihydrofolate reductase 3 164 2.2E-48 T 30-10-2018 IPR001796 Dihydrofolate reductase domain GO:0004146|GO:0046654|GO:0055114 KEGG: 00670+1.5.1.3|KEGG: 00790+1.5.1.3|MetaCyc: PWY-3841|MetaCyc: PWY-6614|Reactome: R-HSA-196757 SMUDGE_53 cf6588b56edd9843930f8da3ee43c097 166 SUPERFAMILY SSF53597 2 165 3.8E-47 T 30-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 SMUDGE_53 cf6588b56edd9843930f8da3ee43c097 166 Gene3D G3DSA:3.40.430.10 1 166 2.3E-48 T 30-10-2018 IPR024072 Dihydrofolate reductase-like domain superfamily Reactome: R-HSA-196757 SMUDGE_146 16b0d26eeb24b02675218e105ed3e91c 108 Pfam PF00216 Bacterial DNA-binding protein 6 90 2.1E-10 T 30-10-2018 IPR000119 Histone-like DNA-binding protein GO:0003677 SMUDGE_146 16b0d26eeb24b02675218e105ed3e91c 108 Gene3D G3DSA:4.10.520.10 5 99 9.4E-7 T 30-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 SMUDGE_146 16b0d26eeb24b02675218e105ed3e91c 108 SUPERFAMILY SSF47729 5 90 2.94E-10 T 30-10-2018 IPR010992 Integration host factor (IHF)-like DNA-binding domain superfamily GO:0003677 SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 SUPERFAMILY SSF54060 4 107 2.82E-31 T 30-10-2018 SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 Gene3D G3DSA:1.10.10.10 115 178 2.3E-9 T 30-10-2018 IPR036388 Winged helix-like DNA-binding domain superfamily SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 SMART SM00507 52 100 2.4E-4 T 30-10-2018 IPR003615 HNH nuclease SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 Pfam PF07463 NUMOD4 motif 4 47 1.6E-10 T 30-10-2018 IPR010902 NUMOD4 GO:0016788 SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 Pfam PF13392 HNH endonuclease 57 100 5.8E-10 T 30-10-2018 IPR003615 HNH nuclease SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 Gene3D G3DSA:3.90.75.20 4 109 6.0E-34 T 30-10-2018 SMUDGE_155 c31db4f6b9112974fbcded626c23d0db 188 SUPERFAMILY SSF64496 109 176 5.89E-14 T 30-10-2018 SMUDGE_68 b3b9a5ababf3dc0957364f6c69b0f15f 278 SUPERFAMILY SSF53271 11 122 2.04E-5 T 30-10-2018 IPR029057 Phosphoribosyltransferase-like SMUDGE_68 b3b9a5ababf3dc0957364f6c69b0f15f 278 Gene3D G3DSA:3.40.50.2020 135 277 4.1E-17 T 30-10-2018 SMUDGE_68 b3b9a5ababf3dc0957364f6c69b0f15f 278 SUPERFAMILY SSF53271 156 263 7.47E-12 T 30-10-2018 IPR029057 Phosphoribosyltransferase-like SMUDGE_68 b3b9a5ababf3dc0957364f6c69b0f15f 278 Gene3D G3DSA:3.40.50.2020 3 133 3.3E-10 T 30-10-2018 SMUDGE_135 63f444caaccba3fde55ed67544f8f810 369 Gene3D G3DSA:1.10.620.20 31 332 1.3E-68 T 30-10-2018 IPR012348 Ribonucleotide reductase-like GO:0016491|GO:0055114 Reactome: R-HSA-499943 SMUDGE_135 63f444caaccba3fde55ed67544f8f810 369 SUPERFAMILY SSF47240 33 332 6.38E-56 T 30-10-2018 IPR009078 Ferritin-like superfamily SMUDGE_135 63f444caaccba3fde55ed67544f8f810 369 Pfam PF00268 Ribonucleotide reductase, small chain 42 322 9.0E-44 T 30-10-2018 IPR000358 Ribonucleotide reductase small subunit family GO:0055114 KEGG: 00230+1.17.4.1|KEGG: 00240+1.17.4.1|KEGG: 00480+1.17.4.1|KEGG: 00983+1.17.4.1|MetaCyc: PWY-6545|MetaCyc: PWY-7184|MetaCyc: PWY-7198|MetaCyc: PWY-7210|MetaCyc: PWY-7220|MetaCyc: PWY-7222|MetaCyc: PWY-7226|MetaCyc: PWY-7227|Reactome: R-HSA-499943 SMUDGE_80 cc1c0ed3b3a3126419936b89719624f4 278 SUPERFAMILY SSF51126 15 219 1.05E-6 T 30-10-2018 IPR011050 Pectin lyase fold/virulence factor SMUDGE_217 998aac9663f221513e855eeed5ebe4a9 255 Gene3D G3DSA:1.10.10.60 49 99 1.9E-5 T 30-10-2018 SMUDGE_217 998aac9663f221513e855eeed5ebe4a9 255 Gene3D G3DSA:1.10.10.60 112 155 4.0E-5 T 30-10-2018 SMUDGE_99 519188d4ca38a428c9f1ba8ac51a9768 1261 Pfam PF01832 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase 1096 1205 2.4E-14 T 30-10-2018 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SMUDGE_99 519188d4ca38a428c9f1ba8ac51a9768 1261 Gene3D G3DSA:1.10.530.10 1089 1207 2.7E-13 T 30-10-2018 SMUDGE_99 519188d4ca38a428c9f1ba8ac51a9768 1261 SMART SM00047 1082 1215 3.6E-7 T 30-10-2018 IPR002901 Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase-like domain GO:0004040 SMUDGE_118 c828a304f9b55910e0261b6867445996 365 Pfam PF00149 Calcineurin-like phosphoesterase 4 215 2.7E-9 T 30-10-2018 IPR004843 Calcineurin-like phosphoesterase domain, ApaH type GO:0016787 SMUDGE_118 c828a304f9b55910e0261b6867445996 365 Gene3D G3DSA:3.60.21.10 4 265 1.1E-34 T 30-10-2018 IPR029052 Metallo-dependent phosphatase-like SMUDGE_118 c828a304f9b55910e0261b6867445996 365 SUPERFAMILY SSF56300 5 303 1.04E-27 T 30-10-2018 SMUDGE_83 cfb0a94a77c97c0c8fcced23ca636098 268 Pfam PF04586 Caudovirus prohead serine protease 38 175 1.2E-4 T 30-10-2018 IPR006433 Prohead protease SMUDGE_228 d7d438f673f6dfa5919ee6a68e8cdb96 249 Pfam PF12706 Beta-lactamase superfamily domain 29 219 9.3E-14 T 30-10-2018 IPR001279 Metallo-beta-lactamase SMUDGE_228 d7d438f673f6dfa5919ee6a68e8cdb96 249 SUPERFAMILY SSF56281 3 223 4.19E-26 T 30-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like SMUDGE_228 d7d438f673f6dfa5919ee6a68e8cdb96 249 SMART SM00849 17 219 0.0014 T 30-10-2018 IPR001279 Metallo-beta-lactamase SMUDGE_228 d7d438f673f6dfa5919ee6a68e8cdb96 249 Gene3D G3DSA:3.60.15.10 7 242 1.8E-23 T 30-10-2018 IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like SMUDGE_130 74234b73012da5b467870a13c9d0dc0e 187 ProDom PD927567 D14 PHAGE GP54 SPO1 GENE ORF78 ORF063 ORF064 11 135 3.0E-21 T 30-10-2018 SMUDGE_114 4d60fddd6e6d3057c8aa169a72076c39 599 SUPERFAMILY SSF46785 25 78 7.69E-5 T 30-10-2018 IPR036390 Winged helix DNA-binding domain superfamily SMUDGE_55 fa3421630c88e9630d0d1fb40f115008 102 Gene3D G3DSA:1.20.5.340 1 101 4.8E-8 T 30-10-2018 SMUDGE_55 fa3421630c88e9630d0d1fb40f115008 102 SUPERFAMILY SSF57997 5 99 6.54E-7 T 30-10-2018 SMUDGE_108 665078fd0079c58c7177da5c6f5810e7 348 Pfam PF04865 Baseplate J-like protein 66 306 3.5E-33 T 30-10-2018 IPR006949 Baseplate protein J-like