locus-tag	class	description
pW2_115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
pW2_126	COG0739	heme binding
pW2_126	COG0741	lytic transglycosylase activity
pW2_126	COG1196	nuclear chromosome segregation
pW2_131	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
pW2_157	COG2195	Cleaves the N-terminal amino acid of tripeptides
pW2_21	COG0187	DNA topoisomerase II activity
pW2_22	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
pW2_237	COG3091	SprT-like family
pW2_246	COG3584	3D domain protein
pW2_246	COG3583	domain protein
pW2_254	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
pW2_26	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
pW2_28	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
pW2_35	COG0194	GDP metabolic process
pW2_47	COG1404	Belongs to the peptidase S8 family
pW2_50	COG0740	serine-type endopeptidase activity
pW2_51	COG1793	dna ligase
pW2_57	COG4474	Belongs to the UPF0398 family
pW2_64	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
pW2_66	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
pW2_67	COG0740	serine-type endopeptidase activity
pW2_68	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
pW2_69	COG1435	thymidine kinase activity
pW2_71	COG0587	DNA-directed DNA polymerase activity
pW2_73	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
pW2_83	COG5632	N-Acetylmuramoyl-L-alanine amidase
pW2_83	COG3409	Peptidoglycan-binding domain 1 protein
pW2_83	COG1388	LysM domain
pW2_89	COG2433	Pfam Transposase IS66
pW2_92	COG0739	heme binding
pW2_92	COG0741	lytic transglycosylase activity
pW2_92	COG1196	nuclear chromosome segregation
pW2_93	COG0582	viral genome integration into host DNA