locus-tag	class	description
CHEWBECCA_109	COG0187	DNA topoisomerase II activity
CHEWBECCA_110	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CHEWBECCA_113	COG1780	Probably involved in ribonucleotide reductase function
CHEWBECCA_115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHEWBECCA_116	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CHEWBECCA_118	COG0756	dUTP diphosphatase activity
CHEWBECCA_123	COG0194	GDP metabolic process
CHEWBECCA_135	COG1404	Belongs to the peptidase S8 family
CHEWBECCA_139	COG0740	serine-type endopeptidase activity
CHEWBECCA_150	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CHEWBECCA_160	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CHEWBECCA_162	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CHEWBECCA_163	COG0740	serine-type endopeptidase activity
CHEWBECCA_165	COG1435	thymidine kinase activity
CHEWBECCA_167	COG0587	DNA-directed DNA polymerase activity
CHEWBECCA_169	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CHEWBECCA_179	COG5632	N-Acetylmuramoyl-L-alanine amidase
CHEWBECCA_179	COG1388	LysM domain
CHEWBECCA_179	COG3409	Peptidoglycan-binding domain 1 protein
CHEWBECCA_185	COG2433	Pfam Transposase IS66
CHEWBECCA_188	COG0739	heme binding
CHEWBECCA_188	COG0741	lytic transglycosylase activity
CHEWBECCA_188	COG1196	nuclear chromosome segregation
CHEWBECCA_189	COG0582	viral genome integration into host DNA
CHEWBECCA_21	COG2195	Cleaves the N-terminal amino acid of tripeptides
CHEWBECCA_231	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CHEWBECCA_243	COG0739	heme binding
CHEWBECCA_247	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CHEWBECCA_54	COG3091	SprT-like family
CHEWBECCA_64	COG1388	LysM domain
CHEWBECCA_64	COG3584	3D domain protein
CHEWBECCA_72	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CHEWBECCA_74	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CHEWBECCA_84	COG0322	excinuclease ABC activity