locus-tag	class	description
MRDARSEY_116	COG0187	DNA topoisomerase II activity
MRDARSEY_117	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MRDARSEY_120	COG1780	Probably involved in ribonucleotide reductase function
MRDARSEY_122	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MRDARSEY_123	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MRDARSEY_125	COG0756	dUTP diphosphatase activity
MRDARSEY_130	COG0194	GDP metabolic process
MRDARSEY_145	COG1404	Belongs to the peptidase S8 family
MRDARSEY_149	COG0740	serine-type endopeptidase activity
MRDARSEY_159	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MRDARSEY_171	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MRDARSEY_172	COG0740	serine-type endopeptidase activity
MRDARSEY_174	COG1435	thymidine kinase activity
MRDARSEY_176	COG0587	DNA-directed DNA polymerase activity
MRDARSEY_179	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MRDARSEY_18	COG2195	Cleaves the N-terminal amino acid of tripeptides
MRDARSEY_189	COG5632	N-Acetylmuramoyl-L-alanine amidase
MRDARSEY_189	COG1388	LysM domain
MRDARSEY_189	COG3409	Peptidoglycan-binding domain 1 protein
MRDARSEY_195	COG2433	Pfam Transposase IS66
MRDARSEY_198	COG0739	heme binding
MRDARSEY_198	COG0741	lytic transglycosylase activity
MRDARSEY_198	COG1196	nuclear chromosome segregation
MRDARSEY_199	COG0582	viral genome integration into host DNA
MRDARSEY_240	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MRDARSEY_252	COG0739	heme binding
MRDARSEY_257	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MRDARSEY_61	COG3091	SprT-like family
MRDARSEY_71	COG1388	LysM domain
MRDARSEY_71	COG3584	3D domain protein
MRDARSEY_72	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MRDARSEY_80	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MRDARSEY_82	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MRDARSEY_93	COG0322	excinuclease ABC activity