locus-tag	class	description
SOPHRITA_102	COG1388	LysM domain
SOPHRITA_102	COG3584	3D domain protein
SOPHRITA_110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
SOPHRITA_137	COG0187	DNA topoisomerase II activity
SOPHRITA_138	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
SOPHRITA_142	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
SOPHRITA_143	COG1780	Probably involved in ribonucleotide reductase function
SOPHRITA_144	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
SOPHRITA_147	COG0756	dUTP diphosphatase activity
SOPHRITA_153	COG0194	GDP metabolic process
SOPHRITA_163	COG1404	Belongs to the peptidase S8 family
SOPHRITA_166	COG0740	serine-type endopeptidase activity
SOPHRITA_174	COG4474	Belongs to the UPF0398 family
SOPHRITA_184	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
SOPHRITA_185	COG0740	serine-type endopeptidase activity
SOPHRITA_187	COG1435	thymidine kinase activity
SOPHRITA_189	COG0587	DNA-directed DNA polymerase activity
SOPHRITA_191	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
SOPHRITA_201	COG1388	LysM domain
SOPHRITA_201	COG3409	Peptidoglycan-binding domain 1 protein
SOPHRITA_201	COG5632	N-Acetylmuramoyl-L-alanine amidase
SOPHRITA_206	COG2433	Pfam Transposase IS66
SOPHRITA_208	COG0739	heme binding
SOPHRITA_208	COG0741	lytic transglycosylase activity
SOPHRITA_208	COG1196	nuclear chromosome segregation
SOPHRITA_209	COG0582	viral genome integration into host DNA
SOPHRITA_22	COG2195	Cleaves the N-terminal amino acid of tripeptides
SOPHRITA_235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
SOPHRITA_250	COG0739	heme binding
SOPHRITA_257	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
SOPHRITA_93	COG3091	SprT-like family