locus-tag	class	description
BpOF4_00005	COG0442	prolyl-tRNA aminoacylation
BpOF4_00010	COG0750	zinc metalloprotease
BpOF4_00015	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BpOF4_00020	COG4589	Belongs to the CDS family
BpOF4_00025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BpOF4_00030	COG0233	cytoplasmic translational termination
BpOF4_00035	COG0528	UMP kinase activity
BpOF4_00040	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BpOF4_00045	COG0052	Belongs to the universal ribosomal protein uS2 family
BpOF4_00065	COG1191	sigma factor activity
BpOF4_00070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BpOF4_00075	COG1776	CheC inhibitor of MCP methylation
BpOF4_00080	COG2201	protein-glutamate methylesterase activity
BpOF4_00085	COG0455	bacterial-type flagellum organization
BpOF4_00090	COG1419	protein localization to endoplasmic reticulum
BpOF4_00095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BpOF4_00100	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BpOF4_00105	COG1684	flagellar biosynthetic protein fliR
BpOF4_00110	COG1987	bacterial-type flagellum assembly
BpOF4_00115	COG1338	Plays a role in the flagellum-specific transport system
BpOF4_00120	COG3190	flagellar
BpOF4_00125	COG2201	protein-glutamate methylesterase activity
BpOF4_00130	COG1776	CheC inhibitor of MCP methylation
BpOF4_00130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BpOF4_00135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BpOF4_00145	COG1582	Flagellar protein (FlbD)
BpOF4_00150	COG4786	Flagellar basal body rod
BpOF4_00160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BpOF4_00180	COG1157	protein secretion by the type III secretion system
BpOF4_00185	COG1317	bacterial-type flagellum organization
BpOF4_00190	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BpOF4_00195	COG1766	The M ring may be actively involved in energy transduction
BpOF4_00200	COG1677	Flagellar hook-basal body complex protein FliE
BpOF4_00205	COG1558	bacterial-type flagellum-dependent cell motility
BpOF4_00210	COG1815	bacterial-type flagellum-dependent cell motility
BpOF4_00215	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BpOF4_00220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BpOF4_00225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BpOF4_00230	COG4974	Belongs to the 'phage' integrase family
BpOF4_00235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BpOF4_00240	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BpOF4_00245	COG0758	DNA mediated transformation
BpOF4_00250	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BpOF4_00255	COG0045	succinate-CoA ligase (ADP-forming) activity
BpOF4_00265	COG2257	FlhB HrpN YscU SpaS Family
BpOF4_00275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BpOF4_00290	COG0335	large ribosomal subunit rRNA binding
BpOF4_00295	COG0336	Belongs to the RNA methyltransferase TrmD family
BpOF4_00300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BpOF4_00310	COG1837	Belongs to the UPF0109 family
BpOF4_00315	COG0228	four-way junction DNA binding
BpOF4_00320	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BpOF4_00325	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BpOF4_00330	COG0552	protein localization to endoplasmic reticulum
BpOF4_00335	COG1196	nuclear chromosome segregation
BpOF4_00340	COG4840	Belongs to the UPF0435 family
BpOF4_00345	COG0571	ribonuclease III activity
BpOF4_00350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BpOF4_00355	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_00360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BpOF4_00365	COG0416	fatty acid biosynthetic process
BpOF4_00370	COG1349	DNA-binding transcription factor activity
BpOF4_00375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BpOF4_00380	COG1760	l-serine dehydratase
BpOF4_00385	COG1760	l-serine dehydratase
BpOF4_00390	COG1307	EDD domain protein, DegV family
BpOF4_00395	COG1461	Dihydroxyacetone kinase
BpOF4_00400	COG1302	Protein conserved in bacteria
BpOF4_00405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BpOF4_00415	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BpOF4_00420	COG1162	GTPase activity
BpOF4_00425	COG0515	serine threonine protein kinase
BpOF4_00425	COG2815	serine threonine protein kinase
BpOF4_00430	COG0631	protein serine/threonine phosphatase activity
BpOF4_00435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BpOF4_00435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BpOF4_00440	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BpOF4_00445	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BpOF4_00450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BpOF4_00455	COG1758	RNA polymerase activity
BpOF4_00460	COG0194	GDP metabolic process
BpOF4_00465	COG2052	Domain of unknown function (DUF370)
BpOF4_00470	COG1561	YicC-like family, N-terminal region
BpOF4_00475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BpOF4_00485	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BpOF4_00495	COG5609	conserved protein (DUF2294)
BpOF4_00515	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BpOF4_00520	COG0284	orotidine-5'-phosphate decarboxylase activity
BpOF4_00525	COG0167	dihydroorotate dehydrogenase activity
BpOF4_00535	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BpOF4_00540	COG0505	Belongs to the CarA family
BpOF4_00545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BpOF4_00550	COG0540	Belongs to the ATCase OTCase family
BpOF4_00555	COG2233	PERMEase
BpOF4_00560	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BpOF4_00565	COG0564	pseudouridine synthase activity
BpOF4_00570	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BpOF4_00575	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BpOF4_00580	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BpOF4_00585	COG3599	regulation of cell shape
BpOF4_00590	COG2302	S4 RNA-binding domain
BpOF4_00595	COG0762	integral membrane protein
BpOF4_00600	COG1799	cell septum assembly
BpOF4_00605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BpOF4_00615	COG1873	PFAM PRC-barrel domain
BpOF4_00620	COG1191	sigma factor activity
BpOF4_00625	COG1191	sigma factor activity
BpOF4_00635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BpOF4_00640	COG0849	cell division
BpOF4_00650	COG3856	small basic protein
BpOF4_00655	COG3879	Bacterial protein of unknown function (DUF881)
BpOF4_00660	COG3879	Bacterial protein of unknown function (DUF881)
BpOF4_00665	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BpOF4_00670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BpOF4_00675	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BpOF4_00680	COG0772	Belongs to the SEDS family
BpOF4_00685	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BpOF4_00690	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BpOF4_00695	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BpOF4_00700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BpOF4_00705	COG0768	penicillin binding
BpOF4_00720	COG0275	rRNA processing
BpOF4_00725	COG2001	Belongs to the MraZ family
BpOF4_00730	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BpOF4_00740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BpOF4_00750	COG0454	-acetyltransferase
BpOF4_00760	COG1024	Enoyl-CoA hydratase
BpOF4_00765	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BpOF4_00770	COG1399	metal-binding, possibly nucleic acid-binding protein
BpOF4_00775	COG1323	Belongs to the UPF0348 family
BpOF4_00780	COG3480	Lon protease (S16) C-terminal proteolytic domain
BpOF4_00785	COG1752	Esterase of the alpha-beta hydrolase superfamily
BpOF4_00790	COG3314	Sporulation integral membrane protein YlbJ
BpOF4_00795	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BpOF4_00800	COG0742	ribosomal rna small subunit methyltransferase
BpOF4_00810	COG2814	Major facilitator Superfamily
BpOF4_00815	COG4471	UPF0298 protein
BpOF4_00830	COG3679	Belongs to the UPF0342 family
BpOF4_00835	COG4294	response to UV
BpOF4_00865	COG2340	Cysteine-rich secretory protein family
BpOF4_00880	COG2801	Transposase and inactivated derivatives
BpOF4_00940	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BpOF4_00950	COG4838	Belongs to the UPF0358 family
BpOF4_00955	COG2066	Belongs to the glutaminase family
BpOF4_00960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BpOF4_00965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BpOF4_00975	COG4896	Protein conserved in bacteria
BpOF4_00995	COG0483	inositol monophosphate 1-phosphatase activity
BpOF4_01005	COG4493	Belongs to the UPF0637 family
BpOF4_01010	COG4476	Belongs to the UPF0223 family
BpOF4_01020	COG1982	Orn Lys Arg decarboxylase major
BpOF4_01040	COG0726	polysaccharide deacetylase
BpOF4_01045	COG4129	membrane
BpOF4_01050	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BpOF4_01075	COG0022	dehydrogenase e1 component
BpOF4_01095	COG0242	peptide deformylase activity
BpOF4_01105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BpOF4_01110	COG0569	domain protein
BpOF4_01115	COG0450	alkyl hydroperoxide reductase
BpOF4_01120	COG0668	transmembrane transport
BpOF4_01140	COG1473	amidohydrolase
BpOF4_01145	COG2171	N-acyltransferase activity
BpOF4_01160	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BpOF4_01165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_01170	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BpOF4_01175	COG1737	Transcriptional regulator
BpOF4_01180	COG1070	Carbohydrate kinase
BpOF4_01185	COG2224	Isocitrate lyase
BpOF4_01195	COG2814	Major facilitator Superfamily
BpOF4_01200	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BpOF4_01205	COG0668	transmembrane transport
BpOF4_01215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BpOF4_01220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BpOF4_01250	COG1797	cobyrinic acid a,c-diamide synthase activity
BpOF4_01270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_01270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_01275	COG2210	Belongs to the sulfur carrier protein TusA family
BpOF4_01300	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BpOF4_01310	COG0309	Hydrogenase expression formation protein (HypE)
BpOF4_01315	COG0409	Hydrogenase expression formation protein
BpOF4_01320	COG0298	carbon dioxide binding
BpOF4_01325	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BpOF4_01330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BpOF4_01335	COG0375	protein maturation
BpOF4_01340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BpOF4_01345	COG3383	formate dehydrogenase (NAD+) activity
BpOF4_01350	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BpOF4_01365	COG4191	Histidine kinase
BpOF4_01370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BpOF4_01380	COG2801	Transposase and inactivated derivatives
BpOF4_01410	COG0508	dehydrogenase complex catalyzes the overall conversion of
BpOF4_01415	COG0022	dehydrogenase e1 component
BpOF4_01420	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BpOF4_01425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BpOF4_01430	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BpOF4_01435	COG3290	protein histidine kinase activity
BpOF4_01435	COG3829	transcription factor binding
BpOF4_01450	COG1215	transferase activity, transferring glycosyl groups
BpOF4_01460	COG0745	RESPONSE REGULATOR receiver
BpOF4_01465	COG2801	Transposase and inactivated derivatives
BpOF4_01475	COG0750	zinc metalloprotease
BpOF4_01480	COG0497	DNA recombination
BpOF4_01485	COG1438	arginine binding
BpOF4_01490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BpOF4_01495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BpOF4_01510	COG0142	geranyltranstransferase activity
BpOF4_01515	COG1722	exodeoxyribonuclease VII activity
BpOF4_01520	COG1570	exodeoxyribonuclease VII activity
BpOF4_01525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BpOF4_01530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BpOF4_01535	COG1302	Protein conserved in bacteria
BpOF4_01540	COG0439	Biotin carboxylase
BpOF4_01545	COG0511	ligase activity, forming carbon-carbon bonds
BpOF4_01590	COG3854	ATPases associated with a variety of cellular activities
BpOF4_01600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BpOF4_01605	COG0006	proline dipeptidase activity
BpOF4_01610	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BpOF4_01625	COG1752	Esterase of the alpha-beta hydrolase superfamily
BpOF4_01630	COG1321	iron dependent repressor
BpOF4_01635	COG1533	DNA photolyase activity
BpOF4_01645	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BpOF4_01655	COG0095	Lipoate-protein ligase
BpOF4_01660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_01665	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BpOF4_01670	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BpOF4_01675	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BpOF4_01680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BpOF4_01695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_01730	COG4537	Required for transformation and DNA binding
BpOF4_01735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BpOF4_01745	COG1459	type II secretion system
BpOF4_01750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BpOF4_01755	COG1970	mechanosensitive ion channel activity
BpOF4_01760	COG1403	HNH endonuclease
BpOF4_01770	COG0210	DNA helicase
BpOF4_01775	COG1418	mRNA catabolic process
BpOF4_01810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BpOF4_01830	COG0589	response to stress
BpOF4_01830	COG0475	glutathione-regulated potassium exporter activity
BpOF4_01835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BpOF4_01845	COG0564	pseudouridine synthase activity
BpOF4_01850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BpOF4_01855	COG2357	RelA SpoT domain protein
BpOF4_01870	COG0741	lytic transglycosylase activity
BpOF4_01875	COG0243	molybdopterin cofactor binding
BpOF4_01880	COG2346	COG2346, Truncated hemoglobins
BpOF4_01890	COG1164	Oligoendopeptidase f
BpOF4_01895	COG4469	Competence protein
BpOF4_01910	COG0861	Integral membrane protein TerC family
BpOF4_01915	COG1393	Belongs to the ArsC family
BpOF4_01925	COG0456	acetyltransferase
BpOF4_01940	COG1272	protein, Hemolysin III
BpOF4_01945	COG1418	mRNA catabolic process
BpOF4_01950	COG0530	calcium, potassium:sodium antiporter activity
BpOF4_01975	COG1063	alcohol dehydrogenase
BpOF4_01990	COG0180	Tryptophanyl-tRNA synthetase
BpOF4_02025	COG0400	carboxylic ester hydrolase activity
BpOF4_02030	COG0346	lactoylglutathione lyase activity
BpOF4_02040	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BpOF4_02045	COG1072	(Pantothenic acid kinase))
BpOF4_02050	COG1686	Belongs to the peptidase S11 family
BpOF4_02055	COG2340	Cysteine-rich secretory protein family
BpOF4_02060	COG3773	Cell wall hydrolase
BpOF4_02070	COG0617	tRNA 3'-terminal CCA addition
BpOF4_02075	COG0427	acetyl-CoA hydrolase
BpOF4_02080	COG1316	TRANSCRIPTIONal
BpOF4_02085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BpOF4_02090	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BpOF4_02115	COG1744	ABC transporter substrate-binding protein PnrA-like
BpOF4_02120	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BpOF4_02140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BpOF4_02145	COG2267	carboxylic ester hydrolase activity
BpOF4_02155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BpOF4_02160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BpOF4_02165	COG0505	Belongs to the CarA family
BpOF4_02175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BpOF4_02180	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BpOF4_02185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BpOF4_02200	COG1999	signal sequence binding
BpOF4_02205	COG3336	cytochrome c oxidase
BpOF4_02210	COG0561	phosphatase activity
BpOF4_02235	COG1966	Carbon starvation protein
BpOF4_02240	COG3279	Response regulator of the LytR AlgR family
BpOF4_02245	COG3275	phosphorelay sensor kinase activity
BpOF4_02250	COG1396	sequence-specific DNA binding
BpOF4_02255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BpOF4_02270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BpOF4_02285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BpOF4_02290	COG1073	alpha beta
BpOF4_02315	COG0425	Belongs to the sulfur carrier protein TusA family
BpOF4_02315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_02320	COG0628	permease
BpOF4_02325	COG1609	Transcriptional regulator
BpOF4_02330	COG3833	ABC-type maltose transport systems, permease component
BpOF4_02335	COG1175	transmembrane transport
BpOF4_02355	COG0534	Mate efflux family protein
BpOF4_02380	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BpOF4_02390	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_02410	COG2204	response regulator
BpOF4_02415	COG5002	protein histidine kinase activity
BpOF4_02425	COG0778	Nitroreductase
BpOF4_02440	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BpOF4_02440	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BpOF4_02450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BpOF4_02455	COG0511	ligase activity, forming carbon-carbon bonds
BpOF4_02460	COG1309	transcriptional regulator
BpOF4_02465	COG1834	amidinotransferase
BpOF4_02480	COG0523	cobalamin synthesis protein
BpOF4_02510	COG1555	photosystem II stabilization
BpOF4_02510	COG3568	Endonuclease Exonuclease Phosphatase
BpOF4_02515	COG2201	protein-glutamate methylesterase activity
BpOF4_02520	COG0835	chemotaxis
BpOF4_02525	COG0643	Histidine kinase
BpOF4_02525	COG2198	Histidine kinase
BpOF4_02530	COG5001	Diguanylate cyclase
BpOF4_02530	COG3300	MHYT domain
BpOF4_02545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BpOF4_02550	COG3639	organic phosphonate transmembrane transporter activity
BpOF4_02555	COG3639	organic phosphonate transmembrane transporter activity
BpOF4_02565	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BpOF4_02570	COG2153	protein acetylation
BpOF4_02595	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BpOF4_02600	COG3829	transcription factor binding
BpOF4_02605	COG0506	proline dehydrogenase activity
BpOF4_02615	COG0704	Plays a role in the regulation of phosphate uptake
BpOF4_02620	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BpOF4_02625	COG0581	inorganic phosphate transmembrane transporter activity
BpOF4_02630	COG0573	inorganic phosphate transmembrane transporter activity
BpOF4_02635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BpOF4_02640	COG0840	transmembrane signaling receptor activity
BpOF4_02645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BpOF4_02650	COG1607	acyl-coa hydrolase
BpOF4_02660	COG2239	Acts as a magnesium transporter
BpOF4_02675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BpOF4_02680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BpOF4_02685	COG0640	Transcriptional regulator
BpOF4_02690	COG0640	Transcriptional regulator
BpOF4_02710	COG1234	tRNA 3'-trailer cleavage
BpOF4_02715	COG1228	amidohydrolase
BpOF4_02725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BpOF4_02730	COG2868	ribosomal protein
BpOF4_02735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BpOF4_02740	COG1530	ribonuclease E activity
BpOF4_02745	COG1994	Peptidase M50
BpOF4_02750	COG0739	heme binding
BpOF4_02755	COG0746	molybdenum cofactor guanylyltransferase activity
BpOF4_02760	COG0667	Aldo Keto reductase
BpOF4_02765	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BpOF4_02770	COG0314	molybdopterin synthase activity
BpOF4_02775	COG1763	Mo-molybdopterin cofactor biosynthetic process
BpOF4_02780	COG0303	'Molybdopterin
BpOF4_02785	COG0521	Mo-molybdopterin cofactor biosynthetic process
BpOF4_02790	COG0315	cyclic pyranopterin monophosphate synthase activity
BpOF4_02795	COG0693	protein deglycase activity
BpOF4_02800	COG2894	cell division
BpOF4_02805	COG0850	regulation of cytokinetic process
BpOF4_02810	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BpOF4_02815	COG1792	Involved in formation and maintenance of cell shape
BpOF4_02820	COG1077	Cell shape determining protein MreB Mrl
BpOF4_02825	COG2003	Belongs to the UPF0758 family
BpOF4_02830	COG0424	maF-like protein
BpOF4_02855	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BpOF4_02860	COG4969	Belongs to the N-Me-Phe pilin family
BpOF4_02875	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BpOF4_02890	COG0285	dihydrofolate synthase activity
BpOF4_02895	COG0525	valine-tRNA ligase activity
BpOF4_02915	COG1388	LysM domain
BpOF4_02915	COG1388	LysM domain
BpOF4_02920	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BpOF4_02925	COG0113	porphobilinogen synthase activity
BpOF4_02930	COG1587	Uroporphyrinogen-III synthase
BpOF4_02935	COG0181	hydroxymethylbilane synthase activity
BpOF4_02940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BpOF4_02945	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BpOF4_02955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BpOF4_02960	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BpOF4_02965	COG1067	ATP-dependent peptidase activity
BpOF4_02965	COG0470	DNA polymerase III
BpOF4_02975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BpOF4_02980	COG0544	peptidyl-prolyl cis-trans isomerase activity
BpOF4_02985	COG1477	protein flavinylation
BpOF4_02985	COG0457	Tetratricopeptide repeat
BpOF4_02990	COG0840	transmembrane signaling receptor activity
BpOF4_02995	COG0066	3-isopropylmalate dehydratase activity
BpOF4_03000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BpOF4_03005	COG0473	3-isopropylmalate dehydrogenase activity
BpOF4_03010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BpOF4_03015	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BpOF4_03020	COG0440	acetolactate synthase activity
BpOF4_03025	COG0028	Belongs to the TPP enzyme family
BpOF4_03035	COG0129	dihydroxy-acid dehydratase activity
BpOF4_03055	COG0622	Phosphoesterase
BpOF4_03060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BpOF4_03065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BpOF4_03070	COG5401	PFAM Sporulation and spore germination
BpOF4_03080	COG1846	Transcriptional regulator
BpOF4_03085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BpOF4_03090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BpOF4_03095	COG3711	transcriptional antiterminator
BpOF4_03100	COG2197	response regulator
BpOF4_03105	COG0824	Thioesterase
BpOF4_03110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BpOF4_03115	COG1053	succinate dehydrogenase
BpOF4_03120	COG2009	succinate dehydrogenase
BpOF4_03125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BpOF4_03130	COG1719	4-vinyl reductase, 4VR
BpOF4_03135	COG0527	aspartate kinase activity
BpOF4_03140	COG0322	excinuclease ABC activity
BpOF4_03145	COG3118	belongs to the thioredoxin family
BpOF4_03150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BpOF4_03155	COG2086	electron transfer activity
BpOF4_03160	COG1024	Enoyl-CoA hydratase
BpOF4_03165	COG1309	transcriptional regulator
BpOF4_03170	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_03175	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_03180	COG3766	membrane
BpOF4_03185	COG1193	negative regulation of DNA recombination
BpOF4_03190	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BpOF4_03190	COG1796	DNA polymerase
BpOF4_03200	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BpOF4_03210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BpOF4_03210	COG0072	phenylalanine-tRNA ligase activity
BpOF4_03215	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BpOF4_03220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BpOF4_03230	COG1363	Peptidase, m42
BpOF4_03250	COG3326	Membrane
BpOF4_03255	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BpOF4_03260	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BpOF4_03265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BpOF4_03270	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BpOF4_03280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BpOF4_03285	COG1484	DNA-dependent DNA replication
BpOF4_03290	COG3611	Membrane attachment protein
BpOF4_03295	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BpOF4_03305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BpOF4_03310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BpOF4_03315	COG0237	dephospho-CoA kinase activity
BpOF4_03320	COG1971	Probably functions as a manganese efflux pump
BpOF4_03330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BpOF4_03330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BpOF4_03335	COG0330	HflC and HflK could
BpOF4_03340	COG0330	HflC and HflK could
BpOF4_03345	COG5002	protein histidine kinase activity
BpOF4_03350	COG0745	RESPONSE REGULATOR receiver
BpOF4_03355	COG0039	L-malate dehydrogenase activity
BpOF4_03360	COG0538	isocitrate dehydrogenase activity
BpOF4_03365	COG0372	Belongs to the citrate synthase family
BpOF4_03370	COG2707	UPF0756 membrane protein
BpOF4_03375	COG3030	protein affecting phage T7 exclusion by the F plasmid
BpOF4_03385	COG0205	6-phosphofructokinase activity
BpOF4_03390	COG0825	malonyl-CoA metabolic process
BpOF4_03395	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BpOF4_03400	COG2186	Transcriptional regulator
BpOF4_03405	COG0281	malic enzyme
BpOF4_03410	COG0587	DNA-directed DNA polymerase activity
BpOF4_03430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BpOF4_03440	COG4109	DRTGG domain
BpOF4_03450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BpOF4_03455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BpOF4_03465	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_03475	COG0165	Argininosuccinate lyase
BpOF4_03480	COG0137	argininosuccinate synthase activity
BpOF4_03490	COG2217	Heavy metal translocating P-type atpase
BpOF4_03500	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BpOF4_03505	COG0827	DNA restriction-modification system
BpOF4_03510	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BpOF4_03515	COG3874	Sporulation protein YtfJ
BpOF4_03525	COG1714	RDD family
BpOF4_03530	COG0616	signal peptide processing
BpOF4_03535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BpOF4_03540	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BpOF4_03545	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BpOF4_03555	COG0301	tRNA thio-modification
BpOF4_03560	COG1104	cysteine desulfurase activity
BpOF4_03565	COG1114	Component of the transport system for branched-chain amino acids
BpOF4_03570	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BpOF4_03575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BpOF4_03580	COG1309	transcriptional regulator
BpOF4_03585	COG1956	GAF domain-containing protein
BpOF4_03590	COG2199	diguanylate cyclase activity
BpOF4_03590	COG2203	Gaf domain
BpOF4_03595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BpOF4_03675	COG1484	DNA-dependent DNA replication
BpOF4_03690	COG4584	PFAM Integrase catalytic
BpOF4_03690	COG2390	Transcriptional regulator
BpOF4_03695	COG1484	DNA-dependent DNA replication
BpOF4_03725	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BpOF4_03735	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BpOF4_03780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BpOF4_03785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BpOF4_03785	COG4499	WXG100 protein secretion system (Wss), protein YukC
BpOF4_03790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BpOF4_03795	COG0454	-acetyltransferase
BpOF4_03800	COG0517	IMP dehydrogenase activity
BpOF4_03805	COG0123	including yeast histone deacetylase and acetoin utilization protein
BpOF4_03810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BpOF4_03820	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BpOF4_03825	COG1609	Transcriptional regulator
BpOF4_03830	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BpOF4_03830	COG1605	Chorismate mutase
BpOF4_03840	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_03845	COG4980	gas vesicle protein
BpOF4_03855	COG2309	aminopeptidase activity
BpOF4_03860	COG1063	alcohol dehydrogenase
BpOF4_03870	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BpOF4_03880	COG1674	ftsk spoiiie
BpOF4_03885	COG4848	Belongs to the UPF0354 family
BpOF4_03890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_03905	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BpOF4_03910	COG1363	Peptidase, m42
BpOF4_03920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_03935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BpOF4_03950	COG0559	Belongs to the binding-protein-dependent transport system permease family
BpOF4_03960	COG0411	ABC transporter
BpOF4_03985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BpOF4_03995	COG0510	thiamine kinase activity
BpOF4_04000	COG0788	formyltetrahydrofolate deformylase activity
BpOF4_04015	COG1346	cytolysis
BpOF4_04020	COG1380	Effector of murein hydrolase LrgA
BpOF4_04030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BpOF4_04035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BpOF4_04040	COG1349	DNA-binding transcription factor activity
BpOF4_04045	COG1187	pseudouridine synthase activity
BpOF4_04055	COG0772	Belongs to the SEDS family
BpOF4_04060	COG0772	Belongs to the SEDS family
BpOF4_04065	COG2244	polysaccharide biosynthetic process
BpOF4_04070	COG2081	HI0933 family
BpOF4_04075	COG0495	leucyl-tRNA aminoacylation
BpOF4_04080	COG2814	Major facilitator Superfamily
BpOF4_04085	COG1242	4 iron, 4 sulfur cluster binding
BpOF4_04090	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BpOF4_04095	COG0288	reversible hydration of carbon dioxide
BpOF4_04100	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_04110	COG2267	carboxylic ester hydrolase activity
BpOF4_04115	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BpOF4_04120	COG0671	phosphoesterase, PA-phosphatase related
BpOF4_04125	COG0438	transferase activity, transferring glycosyl groups
BpOF4_04140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BpOF4_04150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BpOF4_04160	COG1506	peptidase
BpOF4_04165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BpOF4_04170	COG1116	anion transmembrane transporter activity
BpOF4_04175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BpOF4_04180	COG0494	nUDIX hydrolase
BpOF4_04185	COG2814	Major facilitator Superfamily
BpOF4_04195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BpOF4_04200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BpOF4_04215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BpOF4_04220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BpOF4_04230	COG1523	belongs to the glycosyl hydrolase 13 family
BpOF4_04235	COG3237	CsbD-like
BpOF4_04240	COG0488	(ABC) transporter
BpOF4_04250	COG1428	Deoxynucleoside kinase
BpOF4_04255	COG1428	Deoxynucleoside kinase
BpOF4_04265	COG1231	oxidoreductase activity
BpOF4_04300	COG2197	response regulator
BpOF4_04305	COG2203	Gaf domain
BpOF4_04305	COG4585	Histidine kinase
BpOF4_04325	COG1131	(ABC) transporter
BpOF4_04345	COG0395	ABC-type sugar transport system, permease component
BpOF4_04385	COG3546	catalase activity
BpOF4_04395	COG1609	Transcriptional regulator
BpOF4_04400	COG4876	unkown
BpOF4_04405	COG0517	IMP dehydrogenase activity
BpOF4_04550	COG4974	Belongs to the 'phage' integrase family
BpOF4_04555	COG1994	Peptidase M50
BpOF4_04575	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BpOF4_04585	COG0166	Belongs to the GPI family
BpOF4_04595	COG1979	alcohol dehydrogenase
BpOF4_04600	COG2155	Conserved Protein
BpOF4_04605	COG1098	S1 RNA binding domain
BpOF4_04615	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BpOF4_04635	COG0436	Aminotransferase
BpOF4_04640	COG1522	sequence-specific DNA binding
BpOF4_04645	COG1335	isochorismatase
BpOF4_04650	COG0778	Nitroreductase
BpOF4_04655	COG0366	Alpha amylase catalytic
BpOF4_04660	COG1854	S-ribosylhomocysteine lyase activity
BpOF4_04675	COG1295	ribonuclease BN
BpOF4_04680	COG0776	regulation of translation
BpOF4_04685	COG1714	RDD family
BpOF4_04690	COG1268	BioY protein
BpOF4_04695	COG2056	Na+-H+ antiporter family
BpOF4_04700	COG1378	Sugar-specific transcriptional regulator TrmB
BpOF4_04705	COG2814	Major facilitator Superfamily
BpOF4_04715	COG0288	reversible hydration of carbon dioxide
BpOF4_04725	COG5609	conserved protein (DUF2294)
BpOF4_04730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BpOF4_04745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_04750	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BpOF4_04755	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BpOF4_04760	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BpOF4_04765	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BpOF4_04780	COG3584	3D domain protein
BpOF4_04785	COG0840	transmembrane signaling receptor activity
BpOF4_04800	COG2323	membrane
BpOF4_04810	COG1252	NADH dehydrogenase
BpOF4_04815	COG0492	ferredoxin-NADP+ reductase activity
BpOF4_04820	COG0316	Belongs to the HesB IscA family
BpOF4_04830	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BpOF4_04835	COG0039	L-malate dehydrogenase activity
BpOF4_04840	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BpOF4_04850	COG4844	belongs to the
BpOF4_04855	COG1252	NADH dehydrogenase
BpOF4_04860	COG4837	Protein of unknown function (DUF1462)
BpOF4_04865	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_04870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BpOF4_04880	COG0083	homoserine kinase activity
BpOF4_04885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BpOF4_04890	COG0460	homoserine dehydrogenase
BpOF4_04895	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BpOF4_04900	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BpOF4_04910	COG0647	UMP catabolic process
BpOF4_04920	COG2445	Protein of unknown function DUF86
BpOF4_04925	COG1494	fructose-1,6-bisphosphatase
BpOF4_04940	COG4470	Protein conserved in bacteria
BpOF4_04970	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BpOF4_04975	COG0739	heme binding
BpOF4_04985	COG0733	neurotransmitter:sodium symporter activity
BpOF4_04990	COG1757	Na H antiporter
BpOF4_05000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BpOF4_05005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BpOF4_05015	COG3377	Domain of unknown function (DUF1805)
BpOF4_05020	COG0737	Belongs to the 5'-nucleotidase family
BpOF4_05025	COG0730	response to heat
BpOF4_05030	COG1801	Protein of unknown function DUF72
BpOF4_05035	COG0719	Fe-S assembly protein
BpOF4_05040	COG0822	iron-sulfur transferase activity
BpOF4_05045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BpOF4_05050	COG0719	Fe-S assembly protein
BpOF4_05055	COG0396	ATPase activity
BpOF4_05060	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BpOF4_05065	COG1464	Belongs to the NlpA lipoprotein family
BpOF4_05070	COG2011	ABC-type metal ion transport system permease component
BpOF4_05075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BpOF4_05095	COG0509	glycine decarboxylation via glycine cleavage system
BpOF4_05100	COG1393	Belongs to the ArsC family
BpOF4_05110	COG1960	acyl-CoA dehydrogenase activity
BpOF4_05115	COG0183	Belongs to the thiolase family
BpOF4_05120	COG1250	3-hydroxyacyl-CoA dehydrogenase
BpOF4_05120	COG1024	Enoyl-CoA hydratase
BpOF4_05130	COG5577	PFAM Coat F domain
BpOF4_05140	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BpOF4_05145	COG3711	transcriptional antiterminator
BpOF4_05160	COG1131	(ABC) transporter
BpOF4_05175	COG3706	GGDEF domain
BpOF4_05190	COG1301	dicarboxylic acid transport
BpOF4_05195	COG1063	alcohol dehydrogenase
BpOF4_05200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BpOF4_05210	COG1316	TRANSCRIPTIONal
BpOF4_05245	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BpOF4_05250	COG0557	exoribonuclease II activity
BpOF4_05255	COG1647	Serine aminopeptidase, S33
BpOF4_05265	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BpOF4_05270	COG0148	phosphopyruvate hydratase activity
BpOF4_05275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BpOF4_05285	COG0126	phosphoglycerate kinase activity
BpOF4_05290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BpOF4_05305	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BpOF4_05310	COG0740	serine-type endopeptidase activity
BpOF4_05315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BpOF4_05320	COG1481	regulation of sporulation
BpOF4_05325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BpOF4_05330	COG1660	Displays ATPase and GTPase activities
BpOF4_05335	COG1051	belongs to the nudix hydrolase family
BpOF4_05340	COG0492	ferredoxin-NADP+ reductase activity
BpOF4_05345	COG0457	Tetratricopeptide repeat
BpOF4_05355	COG0140	phosphoribosyl-ATP diphosphatase activity
BpOF4_05355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BpOF4_05360	COG0107	imidazoleglycerol-phosphate synthase activity
BpOF4_05365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BpOF4_05370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BpOF4_05375	COG0131	Imidazoleglycerol-phosphate dehydratase
BpOF4_05380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BpOF4_05385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BpOF4_05390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BpOF4_05395	COG0110	maltose O-acetyltransferase activity
BpOF4_05400	COG0546	phosphoglycolate phosphatase activity
BpOF4_05405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BpOF4_05410	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BpOF4_05415	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BpOF4_05420	COG1950	PFAM Membrane protein of
BpOF4_05425	COG1983	PspC domain protein
BpOF4_05430	COG3595	metallopeptidase activity
BpOF4_05435	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BpOF4_05440	COG0556	nucleotide-excision repair
BpOF4_05455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BpOF4_05460	COG0793	Belongs to the peptidase S41A family
BpOF4_05460	COG3409	Peptidoglycan-binding domain 1 protein
BpOF4_05465	COG2223	nitrite transmembrane transporter activity
BpOF4_05470	COG0243	molybdopterin cofactor binding
BpOF4_05475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BpOF4_05480	COG0739	heme binding
BpOF4_05485	COG2177	Part of the ABC transporter FtsEX involved in
BpOF4_05490	COG2884	Cell division ATP-binding protein ftsE
BpOF4_05495	COG2010	Cytochrome c
BpOF4_05500	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BpOF4_05505	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BpOF4_05510	COG0653	protein targeting
BpOF4_05515	COG3290	protein histidine kinase activity
BpOF4_05520	COG4565	transcriptional regulatory protein
BpOF4_05525	COG0471	metal ion transport
BpOF4_05535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BpOF4_05540	COG1278	Cold shock
BpOF4_05560	COG1516	flagellar protein fliS
BpOF4_05570	COG2146	nitrite reductase [NAD(P)H] activity
BpOF4_05575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BpOF4_05580	COG2116	formate transmembrane transporter activity
BpOF4_05585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BpOF4_05585	COG1587	Uroporphyrinogen-III synthase
BpOF4_05595	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BpOF4_05625	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BpOF4_05635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BpOF4_05640	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BpOF4_05650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BpOF4_05650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BpOF4_05655	COG4786	Flagellar basal body rod
BpOF4_05655	COG1256	bacterial-type flagellum assembly
BpOF4_05665	COG2747	anti-sigma28 factor FlgM
BpOF4_05675	COG1040	competence protein
BpOF4_05680	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BpOF4_05690	COG1307	EDD domain protein, DegV family
BpOF4_05705	COG1739	Uncharacterized protein family UPF0029
BpOF4_05710	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BpOF4_05715	COG1522	sequence-specific DNA binding
BpOF4_05720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BpOF4_05725	COG0601	transmembrane transport
BpOF4_05735	COG4608	Belongs to the ABC transporter superfamily
BpOF4_05740	COG0444	Belongs to the ABC transporter superfamily
BpOF4_05755	COG0747	negative chemotaxis
BpOF4_05760	COG4608	Belongs to the ABC transporter superfamily
BpOF4_05765	COG0444	Belongs to the ABC transporter superfamily
BpOF4_05770	COG1316	TRANSCRIPTIONal
BpOF4_05775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BpOF4_05790	COG2244	polysaccharide biosynthetic process
BpOF4_05795	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BpOF4_05800	COG0653	protein targeting
BpOF4_05810	COG0860	N-Acetylmuramoyl-L-alanine amidase
BpOF4_05810	COG2247	cell wall binding repeat
BpOF4_05815	COG4193	domain, Protein
BpOF4_05815	COG5263	repeat protein
BpOF4_05830	COG1404	Belongs to the peptidase S8 family
BpOF4_05845	COG1696	Membrane protein involved in D-alanine export
BpOF4_05850	COG0010	Belongs to the arginase family
BpOF4_05865	COG0840	transmembrane signaling receptor activity
BpOF4_05870	COG0577	efflux transmembrane transporter activity
BpOF4_05875	COG1136	(ABC) transporter
BpOF4_05880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BpOF4_05890	COG1404	Belongs to the peptidase S8 family
BpOF4_05900	COG2340	Cysteine-rich secretory protein family
BpOF4_05910	COG1686	Belongs to the peptidase S11 family
BpOF4_05925	COG0737	Belongs to the 5'-nucleotidase family
BpOF4_05935	COG0737	Belongs to the 5'-nucleotidase family
BpOF4_05945	COG0791	NLP P60 protein
BpOF4_05945	COG1388	LysM domain
BpOF4_05950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BpOF4_06070	COG2801	Transposase and inactivated derivatives
BpOF4_06080	COG1388	LysM domain
BpOF4_06080	COG0791	NLP P60 protein
BpOF4_06085	COG1404	Belongs to the peptidase S8 family
BpOF4_06090	COG4124	Belongs to the glycosyl hydrolase 26 family
BpOF4_06095	COG1649	PFAM Uncharacterised BCR, COG1649
BpOF4_06095	COG0726	polysaccharide deacetylase
BpOF4_06105	COG0860	N-Acetylmuramoyl-L-alanine amidase
BpOF4_06110	COG1388	LysM domain
BpOF4_06110	COG0791	NLP P60 protein
BpOF4_06120	COG0489	protein tyrosine kinase activity
BpOF4_06125	COG3944	biosynthesis protein
BpOF4_06160	COG3177	Filamentation induced by cAMP protein fic
BpOF4_06165	COG0653	protein targeting
BpOF4_06190	COG0367	asparagine synthase
BpOF4_06195	COG0745	RESPONSE REGULATOR receiver
BpOF4_06200	COG5002	protein histidine kinase activity
BpOF4_06230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BpOF4_06300	COG0531	amino acid
BpOF4_06335	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BpOF4_06345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_06350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BpOF4_06355	COG1609	Transcriptional regulator
BpOF4_06365	COG2340	Cysteine-rich secretory protein family
BpOF4_06410	COG0606	chelatase, subunit chli
BpOF4_06500	COG4372	Transposase
BpOF4_06530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BpOF4_06545	COG2244	polysaccharide biosynthetic process
BpOF4_06555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BpOF4_06560	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BpOF4_06570	COG1045	serine acetyltransferase
BpOF4_06575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BpOF4_06580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BpOF4_06590	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BpOF4_06620	COG4464	protein tyrosine phosphatase activity
BpOF4_06645	COG0791	NLP P60 protein
BpOF4_06650	COG2843	Capsule synthesis protein
BpOF4_06660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BpOF4_06670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BpOF4_06685	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_06690	COG1063	alcohol dehydrogenase
BpOF4_06715	COG1129	ABC transporter
BpOF4_06720	COG1131	(ABC) transporter
BpOF4_06730	COG1316	TRANSCRIPTIONal
BpOF4_06760	COG4786	Flagellar basal body rod
BpOF4_06765	COG4786	Flagellar basal body rod
BpOF4_06770	COG1077	Cell shape determining protein MreB Mrl
BpOF4_06775	COG1609	Transcriptional regulator
BpOF4_06780	COG2176	DNA-directed DNA polymerase activity
BpOF4_06785	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BpOF4_06790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BpOF4_06810	COG0739	heme binding
BpOF4_06820	COG2385	sporulation resulting in formation of a cellular spore
BpOF4_06830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BpOF4_06840	COG4836	Membrane
BpOF4_06895	COG1404	Belongs to the peptidase S8 family
BpOF4_06900	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BpOF4_06905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BpOF4_06910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BpOF4_06915	COG4475	Protein of unknown function (DUF436)
BpOF4_06920	COG0698	ribose 5-phosphate isomerase
BpOF4_06925	COG0840	transmembrane signaling receptor activity
BpOF4_06930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BpOF4_06935	COG1971	Probably functions as a manganese efflux pump
BpOF4_06940	COG0009	L-threonylcarbamoyladenylate synthase
BpOF4_06960	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BpOF4_06965	COG0446	pyridine nucleotide-disulphide oxidoreductase
BpOF4_06970	COG0840	transmembrane signaling receptor activity
BpOF4_06980	COG1435	thymidine kinase activity
BpOF4_06985	COG0254	rRNA binding
BpOF4_06990	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BpOF4_06995	COG1494	fructose-1,6-bisphosphatase
BpOF4_07000	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BpOF4_07005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BpOF4_07010	COG0191	fructose-bisphosphate aldolase activity
BpOF4_07015	COG2204	response regulator
BpOF4_07025	COG0504	CTP synthase activity
BpOF4_07030	COG3343	RNA polymerase activity
BpOF4_07035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BpOF4_07035	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BpOF4_07035	COG1703	isobutyryl-CoA mutase activity
BpOF4_07045	COG1960	acyl-CoA dehydrogenase activity
BpOF4_07050	COG1960	acyl-CoA dehydrogenase activity
BpOF4_07055	COG1250	3-hydroxyacyl-CoA dehydrogenase
BpOF4_07060	COG0183	Belongs to the thiolase family
BpOF4_07065	COG0247	lactate metabolic process
BpOF4_07065	COG2181	nitrate reductase activity
BpOF4_07070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BpOF4_07075	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BpOF4_07080	COG0569	domain protein
BpOF4_07085	COG2323	membrane
BpOF4_07100	COG2839	Protein conserved in bacteria
BpOF4_07110	COG0018	arginyl-trna synthetase
BpOF4_07120	COG0010	Belongs to the arginase family
BpOF4_07125	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BpOF4_07130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BpOF4_07150	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BpOF4_07155	COG3829	transcription factor binding
BpOF4_07160	COG3871	stress protein (general stress protein 26)
BpOF4_07180	COG3465	dGTPase activity
BpOF4_07185	COG1078	dGTPase activity
BpOF4_07190	COG1301	dicarboxylic acid transport
BpOF4_07195	COG4844	belongs to the
BpOF4_07200	COG0095	Lipoate-protein ligase
BpOF4_07210	COG0280	phosphate acetyltransferase
BpOF4_07215	COG1024	Enoyl-CoA hydratase
BpOF4_07225	COG3300	MHYT domain
BpOF4_07225	COG5001	Diguanylate cyclase
BpOF4_07230	COG1522	sequence-specific DNA binding
BpOF4_07240	COG3773	Cell wall hydrolase
BpOF4_07255	COG2363	Small membrane protein
BpOF4_07260	COG0456	acetyltransferase
BpOF4_07275	COG0789	Transcriptional regulator
BpOF4_07280	COG2176	DNA-directed DNA polymerase activity
BpOF4_07290	COG0004	ammonium transporteR
BpOF4_07295	COG5577	PFAM Coat F domain
BpOF4_07305	COG0656	L-ascorbic acid biosynthetic process
BpOF4_07310	COG4149	molybdate abc transporter
BpOF4_07325	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BpOF4_07335	COG1404	Belongs to the peptidase S8 family
BpOF4_07340	COG1263	PTS System
BpOF4_07340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_07345	COG4221	oxidoreductase activity
BpOF4_07355	COG1621	beta-fructofuranosidase activity
BpOF4_07365	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BpOF4_07370	COG0351	phosphomethylpyrimidine kinase
BpOF4_07375	COG2962	Rard protein
BpOF4_07390	COG2084	Dehydrogenase
BpOF4_07395	COG4607	ABC-type enterochelin transport system periplasmic component
BpOF4_07400	COG4604	ABC transporter, ATP-binding protein
BpOF4_07405	COG4605	iron ion homeostasis
BpOF4_07410	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BpOF4_07415	COG0513	Belongs to the DEAD box helicase family
BpOF4_07420	COG0366	Alpha amylase catalytic
BpOF4_07425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_07425	COG1263	PTS System
BpOF4_07425	COG2190	(PTS) system
BpOF4_07440	COG2124	cytochrome p450
BpOF4_07445	COG3243	poly(R)-hydroxyalkanoic acid synthase
BpOF4_07455	COG2124	cytochrome p450
BpOF4_07460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BpOF4_07470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BpOF4_07480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BpOF4_07480	COG0723	plastoquinol--plastocyanin reductase activity
BpOF4_07485	COG4895	conserved protein (DUF2196)
BpOF4_07490	COG0346	lactoylglutathione lyase activity
BpOF4_07495	COG0840	transmembrane signaling receptor activity
BpOF4_07505	COG0551	DNA topoisomerase type I activity
BpOF4_07505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BpOF4_07510	COG2076	Multidrug Resistance protein
BpOF4_07515	COG2076	Multidrug Resistance protein
BpOF4_07520	COG3409	Peptidoglycan-binding domain 1 protein
BpOF4_07520	COG3773	Cell wall hydrolase
BpOF4_07525	COG2801	Transposase and inactivated derivatives
BpOF4_07535	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BpOF4_07545	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_07570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BpOF4_07575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BpOF4_07580	COG1454	alcohol dehydrogenase
BpOF4_07605	COG0747	negative chemotaxis
BpOF4_07695	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BpOF4_07700	COG5002	protein histidine kinase activity
BpOF4_07710	COG0693	protein deglycase activity
BpOF4_07720	COG2323	membrane
BpOF4_07725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BpOF4_07745	COG0579	oxidoreductase
BpOF4_07750	COG4682	membrane
BpOF4_07755	COG0450	alkyl hydroperoxide reductase
BpOF4_07760	COG3634	alkyl hydroperoxide reductase activity
BpOF4_07770	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BpOF4_07795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BpOF4_07805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BpOF4_07810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BpOF4_07815	COG4853	Protein conserved in bacteria
BpOF4_07825	COG5002	protein histidine kinase activity
BpOF4_07830	COG0745	RESPONSE REGULATOR receiver
BpOF4_07835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BpOF4_07840	COG0305	Participates in initiation and elongation during chromosome replication
BpOF4_07845	COG0359	binds to the 23S rRNA
BpOF4_07850	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BpOF4_07855	COG4241	membrane
BpOF4_07860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BpOF4_07865	COG0629	single-stranded DNA binding
BpOF4_07870	COG0360	Binds together with S18 to 16S ribosomal RNA
BpOF4_07875	COG0012	GTP binding
BpOF4_07880	COG4481	Protein conserved in bacteria
BpOF4_07885	COG3949	Membrane
BpOF4_07900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BpOF4_07905	COG1475	DNA binding
BpOF4_07910	COG1192	Involved in chromosome partitioning
BpOF4_07915	COG1475	DNA binding
BpOF4_07920	COG0357	Ribosomal RNA small subunit methyltransferase G
BpOF4_07925	COG0445	tRNA wobble uridine modification
BpOF4_07930	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BpOF4_07935	COG1847	R3H domain protein
BpOF4_07940	COG0706	membrane insertase activity
BpOF4_07945	COG0594	ribonuclease P activity
BpOF4_07950	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BpOF4_07955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BpOF4_07960	COG0592	DNA-directed DNA polymerase activity
BpOF4_07965	COG2501	S4 domain
BpOF4_07970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BpOF4_07980	COG0187	DNA topoisomerase II activity
BpOF4_07985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BpOF4_07990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BpOF4_08000	COG0516	GMP reductase activity
BpOF4_08000	COG0517	IMP dehydrogenase activity
BpOF4_08010	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BpOF4_08015	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BpOF4_08020	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BpOF4_08025	COG4608	Belongs to the ABC transporter superfamily
BpOF4_08030	COG0444	Belongs to the ABC transporter superfamily
BpOF4_08035	COG0601	transmembrane transport
BpOF4_08045	COG0747	negative chemotaxis
BpOF4_08050	COG0590	tRNA wobble adenosine to inosine editing
BpOF4_08055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BpOF4_08060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BpOF4_08065	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BpOF4_08095	COG1982	Orn Lys Arg decarboxylase major
BpOF4_08100	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BpOF4_08105	COG3870	Protein conserved in bacteria
BpOF4_08110	COG0470	DNA polymerase III
BpOF4_08115	COG1774	PSP1 C-terminal conserved region
BpOF4_08120	COG4467	Involved in initiation control of chromosome replication
BpOF4_08125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BpOF4_08130	COG2827	Endonuclease containing a URI domain
BpOF4_08135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BpOF4_08140	COG2002	toxin-antitoxin pair type II binding
BpOF4_08155	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BpOF4_08155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BpOF4_08160	COG0084	hydrolase, TatD family'
BpOF4_08165	COG3583	domain protein
BpOF4_08165	COG3584	3D domain protein
BpOF4_08175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BpOF4_08185	COG4466	Protein conserved in bacteria
BpOF4_08200	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BpOF4_08205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BpOF4_08210	COG0251	oxidation-reduction process
BpOF4_08215	COG2088	sporulation resulting in formation of a cellular spore
BpOF4_08220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BpOF4_08225	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BpOF4_08230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BpOF4_08235	COG0193	aminoacyl-tRNA hydrolase activity
BpOF4_08245	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BpOF4_08250	COG2002	toxin-antitoxin pair type II binding
BpOF4_08255	COG2244	polysaccharide biosynthetic process
BpOF4_08260	COG3956	TIGRFAM MazG family protein
BpOF4_08265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BpOF4_08285	COG1098	S1 RNA binding domain
BpOF4_08290	COG2208	phosphoserine phosphatase activity
BpOF4_08295	COG2304	oxidoreductase activity
BpOF4_08300	COG0515	serine threonine protein kinase
BpOF4_08305	COG2966	Psort location CytoplasmicMembrane, score
BpOF4_08315	COG0037	tRNA processing
BpOF4_08330	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BpOF4_08335	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BpOF4_08340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BpOF4_08345	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BpOF4_08350	COG0512	Glutamine amidotransferase of anthranilate synthase
BpOF4_08355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BpOF4_08360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BpOF4_08365	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BpOF4_08370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BpOF4_08375	COG1396	sequence-specific DNA binding
BpOF4_08380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BpOF4_08385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BpOF4_08395	COG3880	PFAM UvrB UvrC protein
BpOF4_08400	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BpOF4_08405	COG0542	response to heat
BpOF4_08410	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BpOF4_08415	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BpOF4_08420	COG4956	integral membrane protein (PIN domain superfamily)
BpOF4_08425	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BpOF4_08435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BpOF4_08440	COG1045	serine acetyltransferase
BpOF4_08445	COG0215	cysteine-tRNA ligase activity
BpOF4_08455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BpOF4_08460	COG3688	RNA-binding protein containing a PIN domain
BpOF4_08470	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BpOF4_08475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BpOF4_08480	COG0250	Participates in transcription elongation, termination and antitermination
BpOF4_08485	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BpOF4_08490	COG0081	regulation of translation
BpOF4_08495	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BpOF4_08500	COG0222	ribosome binding
BpOF4_08505	COG2813	Specifically methylates the guanine in position
BpOF4_08510	COG0085	RNA polymerase activity
BpOF4_08515	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BpOF4_08520	COG1358	cellular component organization or biogenesis
BpOF4_08525	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BpOF4_08530	COG0049	tRNA binding
BpOF4_08535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BpOF4_08540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BpOF4_08545	COG0051	transcription antitermination factor activity, RNA binding
BpOF4_08550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BpOF4_08555	COG0088	Forms part of the polypeptide exit tunnel
BpOF4_08560	COG0089	rRNA binding
BpOF4_08565	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BpOF4_08570	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BpOF4_08575	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BpOF4_08580	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BpOF4_08585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BpOF4_08590	COG0255	Belongs to the universal ribosomal protein uL29 family
BpOF4_08595	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BpOF4_08600	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BpOF4_08605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BpOF4_08610	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BpOF4_08615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BpOF4_08620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BpOF4_08625	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BpOF4_08630	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BpOF4_08635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BpOF4_08640	COG1841	ribosomal large subunit assembly
BpOF4_08645	COG0200	Binds to the 23S rRNA
BpOF4_08650	COG0201	protein transport
BpOF4_08655	COG0563	adenylate kinase activity
BpOF4_08660	COG0024	Methionine aminopeptidase
BpOF4_08670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BpOF4_08675	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BpOF4_08680	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BpOF4_08685	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BpOF4_08690	COG0202	RNA polymerase activity
BpOF4_08695	COG0203	ribosomal protein L17
BpOF4_08700	COG1122	ATPase activity
BpOF4_08705	COG1122	ATPase activity
BpOF4_08715	COG0101	tRNA pseudouridine synthase activity
BpOF4_08720	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BpOF4_08725	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BpOF4_08760	COG0860	N-Acetylmuramoyl-L-alanine amidase
BpOF4_08765	COG0489	protein tyrosine kinase activity
BpOF4_08775	COG2194	sulfuric ester hydrolase activity
BpOF4_08780	COG0726	polysaccharide deacetylase
BpOF4_08800	COG1595	DNA-templated transcription, initiation
BpOF4_08805	COG5662	AntiSigma factor
BpOF4_08810	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BpOF4_08815	COG4856	YbbR-like protein
BpOF4_08820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BpOF4_08825	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BpOF4_08830	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BpOF4_08835	COG2404	hydrolase activity, acting on ester bonds
BpOF4_08840	COG1376	ErfK ybiS ycfS ynhG family protein
BpOF4_08850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BpOF4_08860	COG2801	Transposase and inactivated derivatives
BpOF4_08875	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BpOF4_08880	COG1528	Iron-storage protein
BpOF4_08885	COG2233	PERMEase
BpOF4_08890	COG0450	alkyl hydroperoxide reductase
BpOF4_08895	COG0450	alkyl hydroperoxide reductase
BpOF4_08900	COG2329	Antibiotic biosynthesis monooxygenase
BpOF4_08905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BpOF4_08910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BpOF4_08915	COG2207	Transcriptional regulator
BpOF4_08915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BpOF4_08930	COG4264	IucA IucC family
BpOF4_08940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BpOF4_08950	COG1082	Xylose isomerase domain protein TIM barrel
BpOF4_08975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BpOF4_08980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BpOF4_08985	COG0765	amino acid transport
BpOF4_08990	COG1126	abc transporter atp-binding protein
BpOF4_08995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BpOF4_09000	COG2011	ABC-type metal ion transport system permease component
BpOF4_09005	COG1464	Belongs to the NlpA lipoprotein family
BpOF4_09010	COG0747	negative chemotaxis
BpOF4_09020	COG0493	'glutamate synthase
BpOF4_09025	COG0167	dihydroorotate dehydrogenase activity
BpOF4_09025	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BpOF4_09045	COG2508	Transcriptional regulator
BpOF4_09050	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_09055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BpOF4_09060	COG4191	Histidine kinase
BpOF4_09065	COG5002	protein histidine kinase activity
BpOF4_09070	COG1404	Belongs to the peptidase S8 family
BpOF4_09090	COG1733	regulation of RNA biosynthetic process
BpOF4_09095	COG0655	NAD(P)H dehydrogenase (quinone) activity
BpOF4_09100	COG0589	response to stress
BpOF4_09115	COG2239	Acts as a magnesium transporter
BpOF4_09120	COG3842	ATPase activity
BpOF4_09125	COG2182	Extracellular solute-binding protein
BpOF4_09130	COG1178	ABC-type Fe3 transport system permease component
BpOF4_09145	COG0803	Belongs to the bacterial solute-binding protein 9 family
BpOF4_09150	COG0705	Rhomboid family
BpOF4_09155	COG0736	holo-[acyl-carrier-protein] synthase activity
BpOF4_09160	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BpOF4_09165	COG0864	Transcriptional regulator
BpOF4_09170	COG2337	Toxic component of a toxin-antitoxin (TA) module
BpOF4_09175	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_09180	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_09185	COG2172	sigma factor antagonist activity
BpOF4_09190	COG2208	phosphoserine phosphatase activity
BpOF4_09195	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_09200	COG2172	sigma factor antagonist activity
BpOF4_09205	COG1191	sigma factor activity
BpOF4_09215	COG2183	response to ionizing radiation
BpOF4_09225	COG3091	SprT-like family
BpOF4_09240	COG0626	cystathionine gamma-synthase activity
BpOF4_09245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BpOF4_09250	COG0802	atpase or kinase
BpOF4_09255	COG1214	PFAM Peptidase M22, glycoprotease
BpOF4_09260	COG0456	acetyltransferase
BpOF4_09265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BpOF4_09280	COG0488	(ABC) transporter
BpOF4_09285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BpOF4_09290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BpOF4_09295	COG0805	protein transport
BpOF4_09305	COG2814	Major facilitator Superfamily
BpOF4_09310	COG1271	oxidase subunit
BpOF4_09315	COG1294	oxidase, subunit
BpOF4_09330	COG3835	regulator
BpOF4_09335	COG2610	gluconate transmembrane transporter activity
BpOF4_09340	COG1929	Belongs to the glycerate kinase type-1 family
BpOF4_09350	COG1266	CAAX protease self-immunity
BpOF4_09355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BpOF4_09360	COG0459	protein refolding
BpOF4_09365	COG0446	pyridine nucleotide-disulphide oxidoreductase
BpOF4_09370	COG0583	DNA-binding transcription factor activity
BpOF4_09375	COG0730	response to heat
BpOF4_09380	COG0804	urea catabolic process
BpOF4_09385	COG0832	Belongs to the urease beta subunit family
BpOF4_09390	COG0831	urea catabolic process
BpOF4_09395	COG2851	Citrate transporter
BpOF4_09400	COG4565	transcriptional regulatory protein
BpOF4_09405	COG3290	protein histidine kinase activity
BpOF4_09430	COG4842	Belongs to the WXG100 family
BpOF4_09435	COG5417	Belongs to the EsaB family
BpOF4_09440	COG4499	WXG100 protein secretion system (Wss), protein YukC
BpOF4_09445	COG1674	ftsk spoiiie
BpOF4_09450	COG1511	domain protein
BpOF4_09515	COG2897	thiosulfate sulfurtransferase activity
BpOF4_09520	COG1846	Transcriptional regulator
BpOF4_09535	COG2357	RelA SpoT domain protein
BpOF4_09540	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BpOF4_09545	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BpOF4_09550	COG1957	nucleoside hydrolase
BpOF4_09555	COG1132	(ABC) transporter
BpOF4_09560	COG2226	methyltransferase
BpOF4_09580	COG0714	Associated with various cellular activities
BpOF4_09585	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BpOF4_09590	COG1305	Transglutaminase-like
BpOF4_09595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BpOF4_09595	COG0519	Catalyzes the synthesis of GMP from XMP
BpOF4_09600	COG2252	PERMEase
BpOF4_09620	COG2258	MOSC domain
BpOF4_09625	COG3424	synthase
BpOF4_09630	COG1755	Isoprenylcysteine carboxyl methyltransferase
BpOF4_09635	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BpOF4_09645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BpOF4_09650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BpOF4_09655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BpOF4_09660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BpOF4_09665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BpOF4_09670	COG0047	phosphoribosylformylglycinamidine synthase activity
BpOF4_09675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BpOF4_09680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BpOF4_09685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BpOF4_09690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BpOF4_09695	COG0138	bifunctional purine biosynthesis protein purh
BpOF4_09700	COG0151	Belongs to the GarS family
BpOF4_09715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BpOF4_09720	COG1470	cell adhesion involved in biofilm formation
BpOF4_09725	COG4496	protein, YerC YecD
BpOF4_09730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BpOF4_09740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BpOF4_09750	COG3835	regulator
BpOF4_09755	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BpOF4_09770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BpOF4_09775	COG0686	Belongs to the AlaDH PNT family
BpOF4_09780	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BpOF4_09780	COG2508	Transcriptional regulator
BpOF4_09785	COG1115	amino acid carrier protein
BpOF4_09805	COG0393	Putative heavy-metal-binding
BpOF4_09810	COG0688	phosphatidylethanolamine metabolic process
BpOF4_09830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BpOF4_09835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BpOF4_09845	COG0385	Bile acid
BpOF4_09850	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BpOF4_09855	COG0210	DNA helicase
BpOF4_09860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BpOF4_09865	COG4851	CamS sex pheromone cAM373 precursor
BpOF4_09870	COG1744	ABC transporter substrate-binding protein PnrA-like
BpOF4_09890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BpOF4_09895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BpOF4_09900	COG0154	amidase activity
BpOF4_09905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BpOF4_09910	COG1597	lipid kinase activity
BpOF4_09920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BpOF4_09940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BpOF4_09970	COG0577	efflux transmembrane transporter activity
BpOF4_09975	COG1136	(ABC) transporter
BpOF4_09980	COG0642	Histidine kinase
BpOF4_09985	COG0745	RESPONSE REGULATOR receiver
BpOF4_10015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BpOF4_10025	COG3239	Fatty acid desaturase
BpOF4_10030	COG4585	Histidine kinase
BpOF4_10035	COG2197	response regulator
BpOF4_10050	COG3119	arylsulfatase activity
BpOF4_10065	COG0745	RESPONSE REGULATOR receiver
BpOF4_10070	COG3850	Histidine kinase
BpOF4_10070	COG5002	protein histidine kinase activity
BpOF4_10120	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BpOF4_10130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_10160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BpOF4_10165	COG1984	allophanate hydrolase subunit 2
BpOF4_10170	COG1414	Transcriptional regulator
BpOF4_10175	COG1914	H( )-stimulated, divalent metal cation uptake system
BpOF4_10180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BpOF4_10185	COG0456	acetyltransferase
BpOF4_10185	COG1214	PFAM Peptidase M22, glycoprotease
BpOF4_10190	COG5444	nuclease activity
BpOF4_10210	COG2066	Belongs to the glutaminase family
BpOF4_10230	COG0840	transmembrane signaling receptor activity
BpOF4_10250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BpOF4_10255	COG0733	neurotransmitter:sodium symporter activity
BpOF4_10265	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BpOF4_10275	COG1309	transcriptional regulator
BpOF4_10285	COG1132	(ABC) transporter
BpOF4_10290	COG1132	(ABC) transporter
BpOF4_10305	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_10310	COG1187	pseudouridine synthase activity
BpOF4_10315	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BpOF4_10325	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BpOF4_10335	COG1115	amino acid carrier protein
BpOF4_10340	COG2244	polysaccharide biosynthetic process
BpOF4_10345	COG1263	PTS System
BpOF4_10345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_10350	COG0366	Alpha amylase catalytic
BpOF4_10355	COG2188	Transcriptional regulator
BpOF4_10360	COG0386	Belongs to the glutathione peroxidase family
BpOF4_10365	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BpOF4_10370	COG0488	(ABC) transporter
BpOF4_10375	COG3706	GGDEF domain
BpOF4_10380	COG1349	DNA-binding transcription factor activity
BpOF4_10385	COG1105	Belongs to the carbohydrate kinase PfkB family
BpOF4_10390	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BpOF4_10390	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BpOF4_10390	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BpOF4_10395	COG0154	amidase activity
BpOF4_10400	COG3859	Proton-coupled thiamine transporter YuaJ
BpOF4_10405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BpOF4_10410	COG1404	Belongs to the peptidase S8 family
BpOF4_10425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BpOF4_10435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BpOF4_10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BpOF4_10445	COG1077	Cell shape determining protein MreB Mrl
BpOF4_10450	COG2190	(PTS) system
BpOF4_10450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_10450	COG1263	PTS System
BpOF4_10455	COG3711	transcriptional antiterminator
BpOF4_10460	COG3011	Protein conserved in bacteria
BpOF4_10465	COG0733	neurotransmitter:sodium symporter activity
BpOF4_10480	COG1104	cysteine desulfurase activity
BpOF4_10485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BpOF4_10490	COG0157	Belongs to the NadC ModD family
BpOF4_10500	COG0534	Mate efflux family protein
BpOF4_10515	COG3341	Caulimovirus viroplasmin
BpOF4_10515	COG0328	RNA-DNA hybrid ribonuclease activity
BpOF4_10520	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_10530	COG0753	catalase activity
BpOF4_10550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BpOF4_10555	COG0405	Gamma-glutamyltransferase
BpOF4_10560	COG1522	sequence-specific DNA binding
BpOF4_10565	COG2059	Chromate
BpOF4_10570	COG2059	Chromate
BpOF4_10580	COG0840	transmembrane signaling receptor activity
BpOF4_10585	COG1294	oxidase, subunit
BpOF4_10590	COG1271	oxidase subunit
BpOF4_10610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_10620	COG0477	Major facilitator Superfamily
BpOF4_10630	COG0534	Mate efflux family protein
BpOF4_10635	COG2364	Membrane
BpOF4_10645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BpOF4_10655	COG0535	radical SAM domain protein
BpOF4_10675	COG1278	Cold shock
BpOF4_10700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BpOF4_10715	COG4989	oxidoreductase activity
BpOF4_10720	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_10725	COG4187	Peptidase family M20/M25/M40
BpOF4_10745	COG1126	abc transporter atp-binding protein
BpOF4_10750	COG0765	amino acid transport
BpOF4_10755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BpOF4_10765	COG1917	Cupin 2, conserved barrel domain protein
BpOF4_10770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BpOF4_10775	COG0456	acetyltransferase
BpOF4_10795	COG1090	epimerase
BpOF4_10800	COG2137	regulation of response to DNA damage stimulus
BpOF4_10825	COG1988	membrane-bound metal-dependent
BpOF4_10835	COG1194	a g-specific adenine glycosylase
BpOF4_10840	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_10850	COG0604	alcohol dehydrogenase
BpOF4_10855	COG0436	Aminotransferase
BpOF4_10865	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_10875	COG3557	Belongs to the UPF0374 family
BpOF4_10880	COG1132	(ABC) transporter
BpOF4_10885	COG4129	membrane
BpOF4_10890	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BpOF4_10905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BpOF4_10910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BpOF4_10915	COG3870	Protein conserved in bacteria
BpOF4_10920	COG0735	belongs to the Fur family
BpOF4_10935	COG0129	dihydroxy-acid dehydratase activity
BpOF4_10950	COG2149	membrane
BpOF4_10975	COG5002	protein histidine kinase activity
BpOF4_10980	COG0737	Belongs to the 5'-nucleotidase family
BpOF4_10990	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_10995	COG0783	Belongs to the Dps family
BpOF4_11000	COG3382	B3 4 domain protein
BpOF4_11005	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BpOF4_11010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BpOF4_11020	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BpOF4_11040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BpOF4_11045	COG2766	serine protein kinase
BpOF4_11050	COG2718	Belongs to the UPF0229 family
BpOF4_11070	COG1120	ATPase activity
BpOF4_11085	COG2311	Membrane
BpOF4_11095	COG0436	Aminotransferase
BpOF4_11100	COG3546	catalase activity
BpOF4_11105	COG0473	3-isopropylmalate dehydrogenase activity
BpOF4_11110	COG0179	Fumarylacetoacetate (FAA) hydrolase
BpOF4_11115	COG2226	methyltransferase
BpOF4_11125	COG1115	amino acid carrier protein
BpOF4_11130	COG2610	gluconate transmembrane transporter activity
BpOF4_11140	COG0584	glycerophosphoryl diester phosphodiesterase
BpOF4_11160	COG0058	SHG alpha-glucan phosphorylase activity
BpOF4_11165	COG0297	glycogen (starch) synthase activity
BpOF4_11170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BpOF4_11175	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BpOF4_11190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BpOF4_11190	COG3153	acetyltransferase
BpOF4_11200	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BpOF4_11205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BpOF4_11210	COG1619	proteins homologs of microcin C7 resistance protein MccF
BpOF4_11215	COG2719	SpoVR family
BpOF4_11225	COG1132	(ABC) transporter
BpOF4_11230	COG1132	(ABC) transporter
BpOF4_11235	COG0745	RESPONSE REGULATOR receiver
BpOF4_11240	COG5002	protein histidine kinase activity
BpOF4_11240	COG3850	Histidine kinase
BpOF4_11245	COG3212	peptidase
BpOF4_11260	COG5001	Diguanylate cyclase
BpOF4_11265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BpOF4_11270	COG0733	neurotransmitter:sodium symporter activity
BpOF4_11275	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BpOF4_11280	COG1960	acyl-CoA dehydrogenase activity
BpOF4_11285	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_11290	COG0439	Biotin carboxylase
BpOF4_11295	COG0511	ligase activity, forming carbon-carbon bonds
BpOF4_11300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BpOF4_11305	COG1024	Enoyl-CoA hydratase
BpOF4_11310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BpOF4_11320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BpOF4_11330	COG3842	ATPase activity
BpOF4_11335	COG2508	Transcriptional regulator
BpOF4_11370	COG0561	phosphatase activity
BpOF4_11390	COG1121	(ABC) transporter
BpOF4_11400	COG1668	transmembrane transport
BpOF4_11420	COG0745	RESPONSE REGULATOR receiver
BpOF4_11425	COG2770	Histidine kinase
BpOF4_11425	COG2205	protein histidine kinase activity
BpOF4_11430	COG2814	Major facilitator Superfamily
BpOF4_11435	COG3481	metal-dependent phosphohydrolase, HD sub domain
BpOF4_11445	COG2323	membrane
BpOF4_11455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BpOF4_11475	COG1846	Transcriptional regulator
BpOF4_11495	COG0537	adenosine 5'-monophosphoramidase activity
BpOF4_11500	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_11520	COG1131	(ABC) transporter
BpOF4_11525	COG4473	ABC transporter
BpOF4_11535	COG0785	Cytochrome C biogenesis protein
BpOF4_11545	COG1842	Phage shock protein A
BpOF4_11555	COG4758	membrane
BpOF4_11560	COG4585	Histidine kinase
BpOF4_11565	COG2197	response regulator
BpOF4_11570	COG2329	Antibiotic biosynthesis monooxygenase
BpOF4_11575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BpOF4_11580	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BpOF4_11610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BpOF4_11620	COG3290	protein histidine kinase activity
BpOF4_11625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BpOF4_11630	COG4492	Belongs to the UPF0735 family
BpOF4_11635	COG0077	Prephenate dehydratase
BpOF4_11640	COG1827	regulation of RNA biosynthetic process
BpOF4_11660	COG0632	four-way junction helicase activity
BpOF4_11665	COG2255	four-way junction helicase activity
BpOF4_11675	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BpOF4_11680	COG0343	queuine tRNA-ribosyltransferase activity
BpOF4_11685	COG1862	Preprotein translocase
BpOF4_11695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BpOF4_11700	COG2323	membrane
BpOF4_11715	COG2244	polysaccharide biosynthetic process
BpOF4_11730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BpOF4_11730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BpOF4_11735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BpOF4_11735	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BpOF4_11740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BpOF4_11745	COG5416	Lipopolysaccharide assembly protein A domain
BpOF4_11750	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BpOF4_11750	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BpOF4_11755	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BpOF4_11760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BpOF4_11775	COG0124	histidyl-tRNA synthetase
BpOF4_11780	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BpOF4_11785	COG0460	homoserine dehydrogenase
BpOF4_11795	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BpOF4_11805	COG5002	protein histidine kinase activity
BpOF4_11810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BpOF4_11815	COG2364	Membrane
BpOF4_11820	COG1959	2 iron, 2 sulfur cluster binding
BpOF4_11825	COG1104	cysteine desulfurase activity
BpOF4_11830	COG0482	sulfurtransferase activity
BpOF4_11840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BpOF4_11860	COG0628	permease
BpOF4_11865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BpOF4_11870	COG4472	Bacterial protein of unknown function (DUF965)
BpOF4_11875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BpOF4_11880	COG3906	Belongs to the UPF0473 family
BpOF4_11885	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BpOF4_11905	COG0572	uridine kinase
BpOF4_11910	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BpOF4_11915	COG1960	acyl-CoA dehydrogenase activity
BpOF4_11930	COG2217	Heavy metal translocating P-type atpase
BpOF4_11940	COG2801	Transposase and inactivated derivatives
BpOF4_11965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BpOF4_11980	COG3052	prosthetic group binding
BpOF4_12005	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BpOF4_12015	COG4336	lyase activity
BpOF4_12035	COG0542	response to heat
BpOF4_12040	COG0791	NLP P60 protein
BpOF4_12050	COG0840	transmembrane signaling receptor activity
BpOF4_12070	COG4948	Mandelate Racemase Muconate Lactonizing
BpOF4_12120	COG1131	(ABC) transporter
BpOF4_12125	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BpOF4_12140	COG0277	FAD linked oxidase domain protein
BpOF4_12145	COG2378	regulation of single-species biofilm formation
BpOF4_12175	COG1131	(ABC) transporter
BpOF4_12180	COG3559	Exporter of polyketide antibiotics
BpOF4_12185	COG1595	DNA-templated transcription, initiation
BpOF4_12215	COG0814	amino acid
BpOF4_12225	COG0697	spore germination
BpOF4_12240	COG1132	(ABC) transporter
BpOF4_12245	COG1506	peptidase
BpOF4_12245	COG0823	Involved in the tonB-independent uptake of proteins
BpOF4_12245	COG4946	Tricorn protease homolog
BpOF4_12270	COG1288	antiporter activity
BpOF4_12295	COG0582	viral genome integration into host DNA
BpOF4_12300	COG3263	regulation of cellular component size
BpOF4_12320	COG0745	RESPONSE REGULATOR receiver
BpOF4_12350	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BpOF4_12350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BpOF4_12360	COG0501	Belongs to the peptidase M48B family
BpOF4_12365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_12365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_12370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_12390	COG0561	phosphatase activity
BpOF4_12405	COG1454	alcohol dehydrogenase
BpOF4_12415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BpOF4_12420	COG0583	DNA-binding transcription factor activity
BpOF4_12445	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_12470	COG0789	Transcriptional regulator
BpOF4_12485	COG4565	transcriptional regulatory protein
BpOF4_12490	COG3290	protein histidine kinase activity
BpOF4_12510	COG0039	L-malate dehydrogenase activity
BpOF4_12515	COG4948	Mandelate Racemase Muconate Lactonizing
BpOF4_12520	COG0583	DNA-binding transcription factor activity
BpOF4_12525	COG0028	Belongs to the TPP enzyme family
BpOF4_12530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_12535	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BpOF4_12540	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BpOF4_12550	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_12565	COG2807	transmembrane transport
BpOF4_12570	COG1414	Transcriptional regulator
BpOF4_12590	COG1414	Transcriptional regulator
BpOF4_12630	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_12645	COG1620	l-lactate permease
BpOF4_12650	COG0247	lactate metabolic process
BpOF4_12655	COG1139	Iron-sulfur cluster binding protein
BpOF4_12660	COG1556	Lactate utilization protein
BpOF4_12665	COG2186	Transcriptional regulator
BpOF4_12670	COG3361	conserved protein (COG2071)
BpOF4_12680	COG2271	Major facilitator Superfamily
BpOF4_12725	COG0745	RESPONSE REGULATOR receiver
BpOF4_12725	COG3706	GGDEF domain
BpOF4_12740	COG2234	aminopeptidase activity
BpOF4_12800	COG2188	Transcriptional regulator
BpOF4_12805	COG1486	melibiose metabolic process
BpOF4_12810	COG1263	PTS System
BpOF4_12810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_12810	COG2190	(PTS) system
BpOF4_12815	COG0697	spore germination
BpOF4_12835	COG3383	formate dehydrogenase (NAD+) activity
BpOF4_12860	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BpOF4_12870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BpOF4_12885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BpOF4_12895	COG2814	Major facilitator Superfamily
BpOF4_12900	COG0494	nUDIX hydrolase
BpOF4_12905	COG1846	Transcriptional regulator
BpOF4_12910	COG0095	Lipoate-protein ligase
BpOF4_12925	COG0456	acetyltransferase
BpOF4_12930	COG0671	phosphoesterase, PA-phosphatase related
BpOF4_12935	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_12950	COG0745	RESPONSE REGULATOR receiver
BpOF4_12955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BpOF4_12970	COG5002	protein histidine kinase activity
BpOF4_12980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_12985	COG0785	Cytochrome C biogenesis protein
BpOF4_12995	COG1191	sigma factor activity
BpOF4_13000	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
BpOF4_13005	COG1388	LysM domain
BpOF4_13015	COG2267	carboxylic ester hydrolase activity
BpOF4_13025	COG0840	transmembrane signaling receptor activity
BpOF4_13030	COG2205	protein histidine kinase activity
BpOF4_13040	COG2198	Histidine kinase
BpOF4_13040	COG0784	Response regulator, receiver
BpOF4_13040	COG5002	protein histidine kinase activity
BpOF4_13045	COG3279	Response regulator of the LytR AlgR family
BpOF4_13085	COG0784	Response regulator, receiver
BpOF4_13085	COG2205	protein histidine kinase activity
BpOF4_13085	COG5002	protein histidine kinase activity
BpOF4_13090	COG0671	phosphoesterase, PA-phosphatase related
BpOF4_13095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BpOF4_13100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BpOF4_13125	COG0656	L-ascorbic acid biosynthetic process
BpOF4_13130	COG1785	Belongs to the alkaline phosphatase family
BpOF4_13140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BpOF4_13145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BpOF4_13150	COG1116	anion transmembrane transporter activity
BpOF4_13155	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BpOF4_13160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BpOF4_13165	COG0776	regulation of translation
BpOF4_13170	COG1183	phosphatidylcholine synthase activity
BpOF4_13225	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BpOF4_13230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BpOF4_13235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BpOF4_13240	COG1534	Rna-binding protein
BpOF4_13245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BpOF4_13250	COG1713	HD superfamily hydrolase involved in NAD metabolism
BpOF4_13255	COG0799	negative regulation of ribosome biogenesis
BpOF4_13260	COG2996	Protein conserved in bacteria
BpOF4_13265	COG2226	methyltransferase
BpOF4_13270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BpOF4_13280	COG1596	polysaccharide export
BpOF4_13280	COG1555	photosystem II stabilization
BpOF4_13285	COG2131	deaminase
BpOF4_13290	COG0658	competence protein
BpOF4_13290	COG2333	competence protein COMEC
BpOF4_13300	COG1466	dna polymerase III delta subunit
BpOF4_13305	COG0268	Binds directly to 16S ribosomal RNA
BpOF4_13310	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BpOF4_13315	COG0860	N-Acetylmuramoyl-L-alanine amidase
BpOF4_13330	COG0481	GTPase activity
BpOF4_13335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BpOF4_13340	COG1420	regulation of RNA biosynthetic process
BpOF4_13350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BpOF4_13355	COG0443	Heat shock 70 kDa protein
BpOF4_13360	COG0484	heat shock protein binding
BpOF4_13365	COG2264	protein methyltransferase activity
BpOF4_13370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BpOF4_13375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BpOF4_13380	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BpOF4_13390	COG0697	spore germination
BpOF4_13400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_13405	COG1937	Protein conserved in bacteria
BpOF4_13410	COG1309	transcriptional regulator
BpOF4_13415	COG0183	Belongs to the thiolase family
BpOF4_13425	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_13430	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_13435	COG2610	gluconate transmembrane transporter activity
BpOF4_13440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_13445	COG1285	pathogenesis
BpOF4_13450	COG1937	Protein conserved in bacteria
BpOF4_13455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_13455	COG0425	Belongs to the sulfur carrier protein TusA family
BpOF4_13460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_13460	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_13465	COG0425	Belongs to the sulfur carrier protein TusA family
BpOF4_13475	COG0288	reversible hydration of carbon dioxide
BpOF4_13480	COG2210	Belongs to the sulfur carrier protein TusA family
BpOF4_13485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BpOF4_13490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BpOF4_13500	COG1595	DNA-templated transcription, initiation
BpOF4_13510	COG2824	Alkylphosphonate utilization operon protein PhnA
BpOF4_13520	COG1283	sodium-dependent phosphate transmembrane transporter activity
BpOF4_13530	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_13540	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_13555	COG1250	3-hydroxyacyl-CoA dehydrogenase
BpOF4_13560	COG1024	Enoyl-CoA hydratase
BpOF4_13570	COG2045	Belongs to the ComB family
BpOF4_13575	COG1960	acyl-CoA dehydrogenase activity
BpOF4_13585	COG1024	Enoyl-CoA hydratase
BpOF4_13595	COG0559	Belongs to the binding-protein-dependent transport system permease family
BpOF4_13620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BpOF4_13625	COG1610	YqeY-like protein
BpOF4_13630	COG1030	water channel activity
BpOF4_13635	COG4864	UPF0365 protein
BpOF4_13655	COG1702	phosphate starvation-inducible protein PhoH
BpOF4_13660	COG1480	7TM receptor with intracellular HD hydrolase
BpOF4_13665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BpOF4_13670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BpOF4_13680	COG0295	cytidine deaminase activity
BpOF4_13685	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BpOF4_13695	COG1381	Involved in DNA repair and RecF pathway recombination
BpOF4_13700	COG0752	glycyl-tRNA synthetase alpha subunit
BpOF4_13705	COG0751	glycine-tRNA ligase activity
BpOF4_13710	COG0517	IMP dehydrogenase activity
BpOF4_13715	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BpOF4_13720	COG1671	Belongs to the UPF0178 family
BpOF4_13725	COG0358	DNA primase activity
BpOF4_13730	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BpOF4_13740	COG2010	Cytochrome c
BpOF4_13745	COG2384	SAM-dependent methyltransferase
BpOF4_13750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BpOF4_13755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BpOF4_13760	COG1329	Transcriptional regulator
BpOF4_13770	COG0513	Belongs to the DEAD box helicase family
BpOF4_13775	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BpOF4_13785	COG5002	protein histidine kinase activity
BpOF4_13790	COG1121	(ABC) transporter
BpOF4_13795	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BpOF4_13805	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BpOF4_13815	COG1121	(ABC) transporter
BpOF4_13820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BpOF4_13825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BpOF4_13830	COG0735	belongs to the Fur family
BpOF4_13840	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BpOF4_13845	COG4709	membrane
BpOF4_13850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BpOF4_13855	COG1388	LysM domain
BpOF4_13860	COG2814	Major facilitator Superfamily
BpOF4_13865	COG4086	secreted protein
BpOF4_13885	COG0704	Plays a role in the regulation of phosphate uptake
BpOF4_13890	COG1968	undecaprenyl-diphosphatase activity
BpOF4_13895	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BpOF4_13900	COG0477	Major facilitator Superfamily
BpOF4_13930	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BpOF4_13940	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BpOF4_13945	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BpOF4_13955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BpOF4_13980	COG0705	Rhomboid family
BpOF4_13980	COG0457	Tetratricopeptide repeat
BpOF4_13990	COG0697	spore germination
BpOF4_14010	COG1940	carbohydrate kinase activity
BpOF4_14015	COG1027	Aspartate ammonia-lyase
BpOF4_14025	COG0352	thiamine-phosphate diphosphorylase activity
BpOF4_14035	COG2022	thiamine diphosphate biosynthetic process
BpOF4_14040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BpOF4_14040	COG2022	thiamine diphosphate biosynthetic process
BpOF4_14045	COG0351	phosphomethylpyrimidine kinase
BpOF4_14050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BpOF4_14055	COG0390	transport system, permease component
BpOF4_14065	COG0011	TIGRFAM Protein of
BpOF4_14070	COG2153	protein acetylation
BpOF4_14075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BpOF4_14080	COG2382	esterase
BpOF4_14085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BpOF4_14095	COG0114	fumarate hydratase activity
BpOF4_14100	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BpOF4_14105	COG1725	Transcriptional regulator
BpOF4_14110	COG1131	(ABC) transporter
BpOF4_14120	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BpOF4_14135	COG2818	Glycosylase
BpOF4_14175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BpOF4_14190	COG5002	protein histidine kinase activity
BpOF4_14195	COG0745	RESPONSE REGULATOR receiver
BpOF4_14230	COG0730	response to heat
BpOF4_14235	COG4191	Histidine kinase
BpOF4_14245	COG1280	lysine exporter protein (LysE YggA)
BpOF4_14260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BpOF4_14265	COG0765	amino acid transport
BpOF4_14270	COG1126	abc transporter atp-binding protein
BpOF4_14275	COG4129	membrane
BpOF4_14280	COG1376	ErfK ybiS ycfS ynhG family protein
BpOF4_14285	COG0346	lactoylglutathione lyase activity
BpOF4_14290	COG2195	Cleaves the N-terminal amino acid of tripeptides
BpOF4_14300	COG2801	Transposase and inactivated derivatives
BpOF4_14310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BpOF4_14320	COG2257	FlhB HrpN YscU SpaS Family
BpOF4_14335	COG1728	Protein conserved in bacteria
BpOF4_14350	COG1902	pentaerythritol trinitrate reductase activity
BpOF4_14355	COG0517	IMP dehydrogenase activity
BpOF4_14375	COG0175	sulfate reduction
BpOF4_14380	COG2046	Belongs to the sulfate adenylyltransferase family
BpOF4_14385	COG0306	phosphate transporter
BpOF4_14390	COG0529	Catalyzes the synthesis of activated sulfate
BpOF4_14405	COG2861	carbohydrate metabolic process
BpOF4_14410	COG0789	Transcriptional regulator
BpOF4_14415	COG1587	Uroporphyrinogen-III synthase
BpOF4_14415	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BpOF4_14430	COG1469	GTP cyclohydrolase I activity
BpOF4_14440	COG0527	aspartate kinase activity
BpOF4_14465	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BpOF4_14470	COG0300	oxidoreductase activity
BpOF4_14485	COG0367	asparagine synthase
BpOF4_14490	COG1309	transcriptional regulator
BpOF4_14495	COG1511	domain protein
BpOF4_14515	COG0745	RESPONSE REGULATOR receiver
BpOF4_14515	COG3706	GGDEF domain
BpOF4_14530	COG0745	RESPONSE REGULATOR receiver
BpOF4_14535	COG5002	protein histidine kinase activity
BpOF4_14560	COG1562	ergosterol biosynthetic process
BpOF4_14585	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_14590	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_14595	COG3093	addiction module antidote protein HigA
BpOF4_14605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BpOF4_14610	COG4166	transmembrane transport
BpOF4_14615	COG2190	(PTS) system
BpOF4_14620	COG3711	transcriptional antiterminator
BpOF4_14625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BpOF4_14640	COG1966	Carbon starvation protein
BpOF4_14650	COG0701	Predicted permease
BpOF4_14655	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BpOF4_14660	COG0523	cobalamin synthesis protein
BpOF4_14665	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BpOF4_14670	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BpOF4_14675	COG1850	ribulose-bisphosphate carboxylase activity
BpOF4_14680	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BpOF4_14685	COG0235	Class ii aldolase
BpOF4_14690	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BpOF4_14700	COG0702	epimerase
BpOF4_14710	COG1968	undecaprenyl-diphosphatase activity
BpOF4_14715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_14725	COG0494	nUDIX hydrolase
BpOF4_14730	COG0626	cystathionine gamma-synthase activity
BpOF4_14735	COG1300	Membrane
BpOF4_14740	COG0735	belongs to the Fur family
BpOF4_14750	COG4974	Belongs to the 'phage' integrase family
BpOF4_14755	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BpOF4_14780	COG1764	response to oxidative stress
BpOF4_14790	COG1988	membrane-bound metal-dependent
BpOF4_14795	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BpOF4_14810	COG1301	dicarboxylic acid transport
BpOF4_14820	COG1686	Belongs to the peptidase S11 family
BpOF4_14830	COG2172	sigma factor antagonist activity
BpOF4_14855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BpOF4_14870	COG0697	spore germination
BpOF4_14880	COG0019	diaminopimelate decarboxylase activity
BpOF4_14885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BpOF4_14890	COG0006	proline dipeptidase activity
BpOF4_14900	COG1131	(ABC) transporter
BpOF4_14905	COG1725	Transcriptional regulator
BpOF4_14925	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BpOF4_14925	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BpOF4_14930	COG0307	riboflavin synthase, alpha
BpOF4_14935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BpOF4_14935	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BpOF4_14940	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BpOF4_14950	COG1547	Domain of unknown function (DUF309)
BpOF4_14955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BpOF4_14960	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BpOF4_14965	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BpOF4_14975	COG2323	membrane
BpOF4_15000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BpOF4_15015	COG2323	membrane
BpOF4_15020	COG2323	membrane
BpOF4_15025	COG1686	Belongs to the peptidase S11 family
BpOF4_15030	COG2715	membrane protein required for spore maturation
BpOF4_15035	COG0700	Nucleoside recognition
BpOF4_15040	COG1187	pseudouridine synthase activity
BpOF4_15045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_15050	COG1333	cytochrome c biogenesis protein
BpOF4_15055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BpOF4_15060	COG0745	RESPONSE REGULATOR receiver
BpOF4_15065	COG5002	protein histidine kinase activity
BpOF4_15075	COG0534	Mate efflux family protein
BpOF4_15080	COG5577	PFAM Coat F domain
BpOF4_15090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BpOF4_15095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BpOF4_15100	COG1120	ATPase activity
BpOF4_15105	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BpOF4_15110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BpOF4_15115	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BpOF4_15120	COG1492	cobalamin metabolic process
BpOF4_15125	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BpOF4_15140	COG2096	Adenosyltransferase
BpOF4_15145	COG2720	vancomycin resistance protein
BpOF4_15165	COG0739	heme binding
BpOF4_15175	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BpOF4_15180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BpOF4_15190	COG1141	Ferredoxin
BpOF4_15200	COG0514	ATP-dependent DNA helicase (RecQ)
BpOF4_15230	COG1473	amidohydrolase
BpOF4_15250	COG1408	metallophosphoesterase
BpOF4_15255	COG0789	Transcriptional regulator
BpOF4_15260	COG4862	establishment of competence for transformation
BpOF4_15265	COG1181	Belongs to the D-alanine--D-alanine ligase family
BpOF4_15270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BpOF4_15275	COG0492	ferredoxin-NADP+ reductase activity
BpOF4_15280	COG0252	asparaginase activity
BpOF4_15285	COG2339	peptidase activity
BpOF4_15295	COG0626	cystathionine gamma-synthase activity
BpOF4_15300	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BpOF4_15300	COG0646	methionine synthase
BpOF4_15305	COG1410	methionine synthase
BpOF4_15305	COG0646	methionine synthase
BpOF4_15310	COG3773	Cell wall hydrolase
BpOF4_15310	COG3409	Peptidoglycan-binding domain 1 protein
BpOF4_15315	COG2959	enzyme of heme biosynthesis
BpOF4_15325	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BpOF4_15330	COG0204	Acyl-transferase
BpOF4_15340	COG1304	FMN binding
BpOF4_15355	COG1160	GTP binding
BpOF4_15360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BpOF4_15365	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BpOF4_15385	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BpOF4_15395	COG0142	geranyltranstransferase activity
BpOF4_15415	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BpOF4_15420	COG0142	geranyltranstransferase activity
BpOF4_15425	COG0105	UTP biosynthetic process
BpOF4_15430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BpOF4_15440	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BpOF4_15445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BpOF4_15450	COG4401	Chorismate mutase type I
BpOF4_15460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BpOF4_15465	COG0134	indole-3-glycerol-phosphate synthase activity
BpOF4_15470	COG0135	phosphoribosylanthranilate isomerase activity
BpOF4_15475	COG0133	tryptophan synthase activity
BpOF4_15480	COG0159	tryptophan synthase activity
BpOF4_15485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BpOF4_15490	COG0287	Prephenate dehydrogenase
BpOF4_15495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BpOF4_15505	COG0457	Tetratricopeptide repeat
BpOF4_15510	COG5582	Belongs to the UPF0302 family
BpOF4_15525	COG0723	plastoquinol--plastocyanin reductase activity
BpOF4_15530	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BpOF4_15535	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BpOF4_15535	COG2010	Cytochrome c
BpOF4_15540	COG4347	Protein of unknown function (DUF1405)
BpOF4_15550	COG2738	Putative neutral zinc metallopeptidase
BpOF4_15555	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BpOF4_15560	COG1694	Mazg nucleotide pyrophosphohydrolase
BpOF4_15565	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BpOF4_15570	COG1803	Methylglyoxal synthase
BpOF4_15575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BpOF4_15580	COG0438	transferase activity, transferring glycosyl groups
BpOF4_15600	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BpOF4_15605	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BpOF4_15610	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BpOF4_15620	COG1199	ATP-dependent helicase activity
BpOF4_15620	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BpOF4_15630	COG0402	S-adenosylhomocysteine deaminase activity
BpOF4_15650	COG0436	Aminotransferase
BpOF4_15655	COG0017	Asparaginyl-tRNA synthetase
BpOF4_15660	COG3935	DnaD domain protein
BpOF4_15665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BpOF4_15675	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BpOF4_15685	COG4499	WXG100 protein secretion system (Wss), protein YukC
BpOF4_15685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BpOF4_15690	COG3331	DNA recombination
BpOF4_15705	COG0789	Transcriptional regulator
BpOF4_15720	COG2860	membrane
BpOF4_15730	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BpOF4_15735	COG0835	chemotaxis
BpOF4_15735	COG0784	Response regulator, receiver
BpOF4_15740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BpOF4_15745	COG1234	tRNA 3'-trailer cleavage
BpOF4_15775	COG1413	lyase activity
BpOF4_15785	COG3402	PFAM membrane-flanked domain
BpOF4_15790	COG3428	Bacterial PH domain
BpOF4_15800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_15820	COG0067	glutamate synthase
BpOF4_15820	COG0069	glutamate synthase activity
BpOF4_15820	COG0070	glutamate synthase
BpOF4_15825	COG0493	'glutamate synthase
BpOF4_15855	COG2508	Transcriptional regulator
BpOF4_15865	COG0460	homoserine dehydrogenase
BpOF4_15870	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_15875	COG0006	proline dipeptidase activity
BpOF4_15885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BpOF4_15910	COG0561	phosphatase activity
BpOF4_15925	COG1278	Cold shock
BpOF4_15940	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
BpOF4_15945	COG1278	Cold shock
BpOF4_15955	COG1960	acyl-CoA dehydrogenase activity
BpOF4_15960	COG3012	SEC-C Motif Domain Protein
BpOF4_15960	COG1405	negative regulation of cell septum assembly
BpOF4_15990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BpOF4_15995	COG1205	dead DEAH box helicase
BpOF4_15995	COG1111	helicase
BpOF4_16000	COG3359	exonuclease
BpOF4_16015	COG4474	Belongs to the UPF0398 family
BpOF4_16020	COG3599	regulation of cell shape
BpOF4_16025	COG0328	RNA-DNA hybrid ribonuclease activity
BpOF4_16030	COG0116	Belongs to the methyltransferase superfamily
BpOF4_16045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BpOF4_16055	COG5522	Integral membrane protein (intg_mem_TP0381)
BpOF4_16060	COG4974	Belongs to the 'phage' integrase family
BpOF4_16070	COG0156	8-amino-7-oxononanoate synthase activity
BpOF4_16075	COG2124	cytochrome p450
BpOF4_16080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BpOF4_16090	COG3290	protein histidine kinase activity
BpOF4_16090	COG3829	transcription factor binding
BpOF4_16100	COG2610	gluconate transmembrane transporter activity
BpOF4_16105	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_16110	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_16115	COG1125	glycine betaine transport
BpOF4_16115	COG0517	IMP dehydrogenase activity
BpOF4_16120	COG1174	glycine betaine transport
BpOF4_16130	COG1832	CoA-binding protein
BpOF4_16140	COG0187	DNA topoisomerase II activity
BpOF4_16145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BpOF4_16150	COG0628	permease
BpOF4_16165	COG0596	Alpha beta hydrolase
BpOF4_16185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BpOF4_16200	COG0596	Alpha beta hydrolase
BpOF4_16205	COG0406	alpha-ribazole phosphatase activity
BpOF4_16240	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_16250	COG0110	maltose O-acetyltransferase activity
BpOF4_16255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BpOF4_16265	COG3037	sugar-specific permease SgaT UlaA
BpOF4_16305	COG0076	glutamate decarboxylase activity
BpOF4_16330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BpOF4_16335	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BpOF4_16350	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_16360	COG2226	methyltransferase
BpOF4_16370	COG1595	DNA-templated transcription, initiation
BpOF4_16375	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_16400	COG1595	DNA-templated transcription, initiation
BpOF4_16465	COG0456	acetyltransferase
BpOF4_16465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BpOF4_16520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BpOF4_16545	COG1104	cysteine desulfurase activity
BpOF4_16550	COG0697	spore germination
BpOF4_16555	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_16580	COG1131	(ABC) transporter
BpOF4_16610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BpOF4_16615	COG0010	Belongs to the arginase family
BpOF4_16620	COG1228	amidohydrolase
BpOF4_16625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BpOF4_16640	COG0456	acetyltransferase
BpOF4_16655	COG0737	Belongs to the 5'-nucleotidase family
BpOF4_16690	COG2056	Na+-H+ antiporter family
BpOF4_16695	COG2986	histidine ammonia-lyase
BpOF4_16725	COG2153	protein acetylation
BpOF4_16730	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BpOF4_16760	COG0662	Cupin 2, conserved barrel domain protein
BpOF4_16765	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BpOF4_16775	COG3546	catalase activity
BpOF4_16790	COG0300	oxidoreductase activity
BpOF4_16840	COG1253	flavin adenine dinucleotide binding
BpOF4_16850	COG0577	efflux transmembrane transporter activity
BpOF4_16855	COG1136	(ABC) transporter
BpOF4_16860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BpOF4_16865	COG1253	flavin adenine dinucleotide binding
BpOF4_16880	COG1408	metallophosphoesterase
BpOF4_16885	COG4608	Belongs to the ABC transporter superfamily
BpOF4_16900	COG0601	transmembrane transport
BpOF4_16910	COG0717	Belongs to the dCTP deaminase family
BpOF4_16915	COG0523	cobalamin synthesis protein
BpOF4_16920	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_16925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BpOF4_16930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BpOF4_16935	COG3973	AAA domain
BpOF4_16950	COG0322	excinuclease ABC activity
BpOF4_16955	COG1278	Cold shock
BpOF4_16975	COG4978	Transcriptional regulator
BpOF4_16975	COG0789	Transcriptional regulator
BpOF4_16980	COG2211	Major facilitator Superfamily
BpOF4_17040	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_17050	COG1329	Transcriptional regulator
BpOF4_17065	COG2135	peptidase activity
BpOF4_17115	COG1061	Type III restriction enzyme res subunit
BpOF4_17125	COG1484	DNA-dependent DNA replication
BpOF4_17130	COG4584	PFAM Integrase catalytic
BpOF4_17130	COG2390	Transcriptional regulator
BpOF4_17145	COG0537	adenosine 5'-monophosphoramidase activity
BpOF4_17160	COG0494	nUDIX hydrolase
BpOF4_17200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BpOF4_17215	COG2195	Cleaves the N-terminal amino acid of tripeptides
BpOF4_17290	COG5444	nuclease activity
BpOF4_17310	COG0494	nUDIX hydrolase
BpOF4_17325	COG2202	Pas domain
BpOF4_17325	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_17355	COG0726	polysaccharide deacetylase
BpOF4_17385	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_17415	COG0733	neurotransmitter:sodium symporter activity
BpOF4_17455	COG3173	Aminoglycoside phosphotransferase
BpOF4_17480	COG2259	Doxx family
BpOF4_17485	COG2514	catechol 2,3-dioxygenase activity
BpOF4_17490	COG1733	regulation of RNA biosynthetic process
BpOF4_17510	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BpOF4_17510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BpOF4_17540	COG3708	Transcriptional regulator
BpOF4_17540	COG2207	Transcriptional regulator
BpOF4_17555	COG0534	Mate efflux family protein
BpOF4_17585	COG0464	growth
BpOF4_17595	COG1595	DNA-templated transcription, initiation
BpOF4_17610	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BpOF4_17640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BpOF4_17650	COG0659	secondary active sulfate transmembrane transporter activity
BpOF4_17655	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_17665	COG0183	Belongs to the thiolase family
BpOF4_17720	COG1522	sequence-specific DNA binding
BpOF4_17775	COG2304	oxidoreductase activity
BpOF4_17790	COG1253	flavin adenine dinucleotide binding
BpOF4_17820	COG0842	Transport permease protein
BpOF4_17830	COG1131	(ABC) transporter
BpOF4_17835	COG2197	response regulator
BpOF4_17840	COG4585	Histidine kinase
BpOF4_17865	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BpOF4_17870	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
BpOF4_17890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BpOF4_17895	COG0318	PFAM AMP-dependent synthetase and ligase
BpOF4_17900	COG3876	Protein conserved in bacteria
BpOF4_17905	COG1472	Belongs to the glycosyl hydrolase 3 family
BpOF4_17915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_17915	COG1263	PTS System
BpOF4_17920	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BpOF4_17925	COG1737	Transcriptional regulator
BpOF4_17935	COG0860	N-Acetylmuramoyl-L-alanine amidase
BpOF4_17960	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BpOF4_17985	COG1609	Transcriptional regulator
BpOF4_17995	COG5578	integral membrane protein
BpOF4_18000	COG0395	ABC-type sugar transport system, permease component
BpOF4_18005	COG1175	transmembrane transport
BpOF4_18015	COG2723	6-phospho-beta-galactosidase activity
BpOF4_18045	COG2217	Heavy metal translocating P-type atpase
BpOF4_18055	COG1937	Protein conserved in bacteria
BpOF4_18060	COG1120	ATPase activity
BpOF4_18065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BpOF4_18070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BpOF4_18075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BpOF4_18080	COG4191	Histidine kinase
BpOF4_18085	COG4191	Histidine kinase
BpOF4_18090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BpOF4_18095	COG1028	Short-chain dehydrogenase reductase Sdr
BpOF4_18100	COG0798	PFAM Bile acid sodium symporter
BpOF4_18110	COG3493	citrate carrier protein
BpOF4_18120	COG4565	transcriptional regulatory protein
BpOF4_18125	COG3290	protein histidine kinase activity
BpOF4_18130	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BpOF4_18140	COG0659	secondary active sulfate transmembrane transporter activity
BpOF4_18170	COG2318	DinB family
BpOF4_18180	COG0402	S-adenosylhomocysteine deaminase activity
BpOF4_18190	COG0583	DNA-binding transcription factor activity
BpOF4_18210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BpOF4_18225	COG2312	Erythromycin esterase
BpOF4_18245	COG0515	serine threonine protein kinase
BpOF4_18245	COG2815	serine threonine protein kinase
BpOF4_18280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BpOF4_18285	COG0785	Cytochrome C biogenesis protein
BpOF4_18325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BpOF4_18330	COG2808	Putative FMN-binding domain
BpOF4_18345	COG2323	membrane
BpOF4_18350	COG4821	SIS domain
BpOF4_18360	COG0363	glucosamine-6-phosphate deaminase activity
BpOF4_18365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BpOF4_18370	COG1263	PTS System
BpOF4_18370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BpOF4_18400	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
BpOF4_18405	COG4145	pantothenate transmembrane transporter activity
BpOF4_18415	COG2720	vancomycin resistance protein
BpOF4_18425	COG1388	LysM domain
BpOF4_18425	COG3858	chitin binding
BpOF4_18435	COG0432	Pfam Uncharacterised protein family UPF0047
BpOF4_18440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BpOF4_18445	COG3285	dna ligase
BpOF4_18445	COG1793	dna ligase
BpOF4_18450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BpOF4_18455	COG4988	ABC transporter
BpOF4_18475	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BpOF4_18480	COG5002	protein histidine kinase activity
BpOF4_18485	COG0745	RESPONSE REGULATOR receiver
BpOF4_18505	COG0840	transmembrane signaling receptor activity
BpOF4_18515	COG0183	Belongs to the thiolase family
BpOF4_18520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BpOF4_18535	COG2340	Cysteine-rich secretory protein family
BpOF4_18540	COG1215	transferase activity, transferring glycosyl groups
BpOF4_18570	COG0561	phosphatase activity
BpOF4_18585	COG0708	Exodeoxyribonuclease III
BpOF4_18590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BpOF4_18595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BpOF4_18600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BpOF4_18605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BpOF4_18615	COG1509	lysine 2,3-aminomutase activity
BpOF4_18620	COG0456	acetyltransferase
BpOF4_18625	COG3829	transcription factor binding
BpOF4_18640	COG0655	NAD(P)H dehydrogenase (quinone) activity
BpOF4_18645	COG1199	ATP-dependent helicase activity
BpOF4_18650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BpOF4_18665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BpOF4_18680	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BpOF4_18700	COG1597	lipid kinase activity
BpOF4_18710	COG2094	Belongs to the DNA glycosylase MPG family
BpOF4_18715	COG0604	alcohol dehydrogenase
BpOF4_18720	COG1587	Uroporphyrinogen-III synthase
BpOF4_18725	COG1164	Oligoendopeptidase f
BpOF4_18750	COG3069	C4-dicarboxylate transmembrane transporter activity
BpOF4_18775	COG0436	Aminotransferase
BpOF4_18795	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BpOF4_18800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BpOF4_18810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BpOF4_18825	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BpOF4_18835	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BpOF4_18865	COG3118	belongs to the thioredoxin family
BpOF4_18875	COG0514	ATP-dependent DNA helicase (RecQ)
BpOF4_18885	COG0488	(ABC) transporter
BpOF4_18890	COG0180	Tryptophanyl-tRNA synthetase
BpOF4_18895	COG0697	spore germination
BpOF4_18905	COG0586	Pfam SNARE associated Golgi protein
BpOF4_18915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BpOF4_18920	COG0508	dehydrogenase complex catalyzes the overall conversion of
BpOF4_18925	COG0567	Dehydrogenase, E1 component
BpOF4_18935	COG2391	methyltransferase activity
BpOF4_18945	COG0778	Nitroreductase
BpOF4_18955	COG0500	methyltransferase
BpOF4_18960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BpOF4_19000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BpOF4_19010	COG0720	synthase
BpOF4_19015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BpOF4_19020	COG2309	aminopeptidase activity
BpOF4_19040	COG1309	transcriptional regulator
BpOF4_19055	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BpOF4_19075	COG4841	protein insertion into membrane
BpOF4_19090	COG0835	chemotaxis
BpOF4_19090	COG0784	Response regulator, receiver
BpOF4_19115	COG0071	Belongs to the small heat shock protein (HSP20) family
BpOF4_19155	COG2200	EAL domain
BpOF4_19160	COG2267	carboxylic ester hydrolase activity
BpOF4_19165	COG2770	Histidine kinase
BpOF4_19165	COG3437	response regulator, receiver
BpOF4_19170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BpOF4_19190	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BpOF4_19210	COG0824	Thioesterase
BpOF4_19215	COG0464	growth
BpOF4_19220	COG0697	spore germination
BpOF4_19235	COG0398	Pfam SNARE associated Golgi protein
BpOF4_19255	COG2323	membrane
BpOF4_19280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BpOF4_19300	COG1607	acyl-coa hydrolase
BpOF4_19315	COG0709	Synthesizes selenophosphate from selenide and ATP
BpOF4_19320	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BpOF4_19330	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BpOF4_19355	COG1408	metallophosphoesterase
BpOF4_19365	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BpOF4_19365	COG4499	WXG100 protein secretion system (Wss), protein YukC
BpOF4_19370	COG1388	LysM domain
BpOF4_19370	COG3584	3D domain protein
BpOF4_19385	COG0686	Belongs to the AlaDH PNT family
BpOF4_19395	COG4846	Membrane protein involved in cytochrome C biogenesis
BpOF4_19405	COG1132	(ABC) transporter
BpOF4_19410	COG1132	(ABC) transporter
BpOF4_19425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BpOF4_19430	COG4224	UPF0291 protein
BpOF4_19435	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BpOF4_19445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BpOF4_19465	COG0174	glutamine synthetase
BpOF4_19470	COG0789	Transcriptional regulator
BpOF4_19475	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BpOF4_19485	COG0464	growth
BpOF4_19495	COG1923	regulation of RNA biosynthetic process
BpOF4_19500	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BpOF4_19505	COG2136	Putative SAM-dependent methyltransferase
BpOF4_19505	COG2521	methyltransferase
BpOF4_19510	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BpOF4_19515	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BpOF4_19525	COG4550	Control of competence regulator ComK, YlbF/YmcA
BpOF4_19530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BpOF4_19535	COG1013	pyruvate-flavodoxin oxidoreductase activity
BpOF4_19540	COG0674	pyruvate-flavodoxin oxidoreductase activity
BpOF4_19540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BpOF4_19545	COG2359	stage V sporulation protein S
BpOF4_19550	COG1692	metallophosphoesterase
BpOF4_19555	COG1418	mRNA catabolic process
BpOF4_19570	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BpOF4_19580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BpOF4_19585	COG0513	Belongs to the DEAD box helicase family
BpOF4_19590	COG1058	Belongs to the CinA family
BpOF4_19590	COG1546	Belongs to the CinA family
BpOF4_19595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BpOF4_19600	COG1666	GTP binding
BpOF4_19605	COG1426	Protein conserved in bacteria
BpOF4_19620	COG0300	oxidoreductase activity
BpOF4_19625	COG0612	Peptidase, M16
BpOF4_19630	COG0612	Peptidase, M16
BpOF4_19635	COG2188	Transcriptional regulator
BpOF4_19640	COG1674	ftsk spoiiie
BpOF4_19650	COG0740	serine-type endopeptidase activity
BpOF4_19655	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BpOF4_19660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BpOF4_19665	COG0527	aspartate kinase activity
BpOF4_19670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BpOF4_19675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BpOF4_19680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BpOF4_19685	COG1873	PFAM PRC-barrel domain
BpOF4_19690	COG0612	Peptidase, M16
BpOF4_19695	COG0726	polysaccharide deacetylase
BpOF4_19700	COG1185	polyribonucleotide nucleotidyltransferase activity
BpOF4_19705	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BpOF4_19710	COG0196	riboflavin kinase activity
BpOF4_19715	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BpOF4_19720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BpOF4_19730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BpOF4_19735	COG1358	cellular component organization or biogenesis
BpOF4_19740	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BpOF4_19745	COG0195	Participates in both transcription termination and antitermination
BpOF4_19750	COG0779	Required for maturation of 30S ribosomal subunits
BpOF4_19755	COG2176	DNA-directed DNA polymerase activity
BpOF4_19979	COG0783	Belongs to the Dps family
BpOF4_19984	COG0840	transmembrane signaling receptor activity
BpOF4_20009	COG5444	nuclease activity
BpOF4_20019	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BpOF4_20089	COG1793	dna ligase
BpOF4_20124	COG0629	single-stranded DNA binding
BpOF4_20139	COG4974	Belongs to the 'phage' integrase family
BpOF4_20144	COG4974	Belongs to the 'phage' integrase family
BpOF4_20149	COG4956	integral membrane protein (PIN domain superfamily)
BpOF4_20189	COG2217	Heavy metal translocating P-type atpase
BpOF4_20229	COG3344	reverse transcriptase
BpOF4_20234	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BpOF4_20234	COG0456	acetyltransferase
BpOF4_20244	COG2390	Transcriptional regulator
BpOF4_20244	COG4584	PFAM Integrase catalytic
BpOF4_20249	COG1484	DNA-dependent DNA replication
BpOF4_20264	COG3879	Bacterial protein of unknown function (DUF881)
BpOF4_20299	COG5002	protein histidine kinase activity
BpOF4_20304	COG0745	RESPONSE REGULATOR receiver
BpOF4_20324	COG3336	cytochrome c oxidase
BpOF4_20369	COG0398	Pfam SNARE associated Golgi protein
BpOF4_20394	COG1876	peptidase activity
BpOF4_20429	COG0860	N-Acetylmuramoyl-L-alanine amidase
BpOF4_20444	COG0367	asparagine synthase
BpOF4_20454	COG0785	Cytochrome C biogenesis protein
BpOF4_20459	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BpOF4_20464	COG1333	cytochrome c biogenesis protein
BpOF4_20469	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BpOF4_20474	COG5002	protein histidine kinase activity
BpOF4_20479	COG0745	RESPONSE REGULATOR receiver
BpOF4_20489	COG0803	Belongs to the bacterial solute-binding protein 9 family
BpOF4_20489	COG3443	Belongs to the bacterial solute-binding protein 9 family
BpOF4_20494	COG2132	Multicopper oxidase
BpOF4_20504	COG0803	Belongs to the bacterial solute-binding protein 9 family
BpOF4_20509	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BpOF4_20514	COG1121	(ABC) transporter
BpOF4_20539	COG4974	Belongs to the 'phage' integrase family
BpOF4_20599	COG0739	heme binding
BpOF4_20599	COG0741	lytic transglycosylase activity
BpOF4_20599	COG1196	nuclear chromosome segregation
BpOF4_20614	COG2274	protein secretion by the type I secretion system
BpOF4_20679	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BpOF4_20689	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BpOF4_20754	COG0561	phosphatase activity
BpOF4_20759	COG2364	Membrane
BpOF4_20764	COG1609	Transcriptional regulator
BpOF4_20834	COG2003	Belongs to the UPF0758 family
BpOF4_20839	COG0629	single-stranded DNA binding
BpOF4_21159	COG3706	GGDEF domain
BpOF4_21159	COG0745	RESPONSE REGULATOR receiver
BpOF4_21214	COG3583	domain protein
BpOF4_21214	COG3584	3D domain protein
BpOF4_21264	COG1466	dna polymerase III delta subunit
BpOF4_21269	COG0592	DNA-directed DNA polymerase activity
BpOF4_21309	COG5001	Diguanylate cyclase
BpOF4_21309	COG4251	negative regulation of phosphorylation
BpOF4_21309	COG3706	GGDEF domain
BpOF4_21309	COG2203	Gaf domain
BpOF4_21314	COG5001	Diguanylate cyclase
BpOF4_21314	COG1716	ATPase activity
BpOF4_21429	COG1051	belongs to the nudix hydrolase family
BpOF4_21444	COG1484	DNA-dependent DNA replication
BpOF4_21449	COG2390	Transcriptional regulator
BpOF4_21449	COG4584	PFAM Integrase catalytic
BpOF4_21494	COG1609	Transcriptional regulator
BpOF4_21499	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BpOF4_21504	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BpOF4_21514	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BpOF4_21524	COG1012	belongs to the aldehyde dehydrogenase family
BpOF4_21529	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BpOF4_21534	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BpOF4_21579	COG0582	viral genome integration into host DNA
BpOF4_21584	COG3263	regulation of cellular component size
BpOF4_21614	COG0704	Plays a role in the regulation of phosphate uptake
BpOF4_21649	COG1366	Belongs to the anti-sigma-factor antagonist family
BpOF4_21679	COG1609	Transcriptional regulator
BpOF4_21794	COG4974	Belongs to the 'phage' integrase family
BpOF4_21914	COG0433	COG0433 Predicted ATPase
BpOF4_21929	COG0791	NLP P60 protein
BpOF4_21929	COG0741	lytic transglycosylase activity
BpOF4_21939	COG2002	toxin-antitoxin pair type II binding
BpOF4_21969	COG0741	lytic transglycosylase activity
BpOF4_21969	COG0791	NLP P60 protein
BpOF4_22004	COG1131	(ABC) transporter