locus-tag	class	description
C5695_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C5695_00010	COG0592	DNA-directed DNA polymerase activity
C5695_00015	COG2501	S4 domain
C5695_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C5695_00030	COG0187	DNA topoisomerase II activity
C5695_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5695_00070	COG0516	GMP reductase activity
C5695_00070	COG0517	IMP dehydrogenase activity
C5695_00075	COG1686	Belongs to the peptidase S11 family
C5695_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5695_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C5695_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C5695_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C5695_00100	COG0840	transmembrane signaling receptor activity
C5695_00110	COG1428	Deoxynucleoside kinase
C5695_00115	COG1428	Deoxynucleoside kinase
C5695_00120	COG1388	LysM domain
C5695_00120	COG3858	chitin binding
C5695_00125	COG1335	isochorismatase
C5695_00130	COG0590	tRNA wobble adenosine to inosine editing
C5695_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5695_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C5695_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C5695_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C5695_00200	COG3853	Toxic anion resistance protein (TelA)
C5695_00205	COG1982	Orn Lys Arg decarboxylase major
C5695_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5695_00215	COG3870	Protein conserved in bacteria
C5695_00220	COG1728	Protein conserved in bacteria
C5695_00225	COG0470	DNA polymerase III
C5695_00230	COG1774	PSP1 C-terminal conserved region
C5695_00235	COG4467	Involved in initiation control of chromosome replication
C5695_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C5695_00245	COG2827	Endonuclease containing a URI domain
C5695_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5695_00255	COG2002	toxin-antitoxin pair type II binding
C5695_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5695_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5695_00265	COG0084	hydrolase, TatD family'
C5695_00270	COG3584	3D domain protein
C5695_00270	COG3583	domain protein
C5695_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C5695_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5695_00290	COG4466	Protein conserved in bacteria
C5695_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5695_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5695_00310	COG0251	oxidation-reduction process
C5695_00315	COG2088	sporulation resulting in formation of a cellular spore
C5695_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5695_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C5695_00335	COG0193	aminoacyl-tRNA hydrolase activity
C5695_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5695_00350	COG2002	toxin-antitoxin pair type II binding
C5695_00355	COG2244	polysaccharide biosynthetic process
C5695_00360	COG3956	TIGRFAM MazG family protein
C5695_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5695_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5695_00385	COG1098	S1 RNA binding domain
C5695_00400	COG2208	phosphoserine phosphatase activity
C5695_00405	COG2304	oxidoreductase activity
C5695_00410	COG0515	serine threonine protein kinase
C5695_00415	COG0037	tRNA processing
C5695_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5695_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C5695_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C5695_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5695_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5695_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C5695_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
C5695_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5695_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C5695_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C5695_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C5695_00480	COG1396	sequence-specific DNA binding
C5695_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5695_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5695_00570	COG4463	regulation of RNA biosynthetic process
C5695_00575	COG3880	PFAM UvrB UvrC protein
C5695_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C5695_00585	COG0542	response to heat
C5695_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C5695_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C5695_00600	COG4956	integral membrane protein (PIN domain superfamily)
C5695_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5695_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C5695_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5695_00620	COG1045	serine acetyltransferase
C5695_00625	COG0215	cysteine-tRNA ligase activity
C5695_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C5695_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5695_00640	COG3688	RNA-binding protein containing a PIN domain
C5695_00645	COG1595	DNA-templated transcription, initiation
C5695_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5695_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5695_00660	COG0250	Participates in transcription elongation, termination and antitermination
C5695_00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C5695_00670	COG0081	regulation of translation
C5695_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C5695_00680	COG0222	ribosome binding
C5695_00685	COG2813	Specifically methylates the guanine in position
C5695_00690	COG0085	RNA polymerase activity
C5695_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5695_00700	COG1358	cellular component organization or biogenesis
C5695_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C5695_00710	COG0049	tRNA binding
C5695_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C5695_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C5695_00725	COG0596	Alpha beta hydrolase
C5695_00730	COG0051	transcription antitermination factor activity, RNA binding
C5695_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C5695_00740	COG0088	Forms part of the polypeptide exit tunnel
C5695_00745	COG0089	rRNA binding
C5695_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C5695_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C5695_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C5695_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C5695_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C5695_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
C5695_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C5695_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C5695_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C5695_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C5695_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5695_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C5695_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5695_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C5695_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5695_00825	COG1841	ribosomal large subunit assembly
C5695_00830	COG0200	Binds to the 23S rRNA
C5695_00835	COG0201	protein transport
C5695_00840	COG0563	adenylate kinase activity
C5695_00845	COG0024	Methionine aminopeptidase
C5695_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5695_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C5695_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C5695_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C5695_00875	COG0202	RNA polymerase activity
C5695_00880	COG0203	ribosomal protein L17
C5695_00885	COG1122	ATPase activity
C5695_00890	COG1122	ATPase activity
C5695_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5695_00900	COG0101	tRNA pseudouridine synthase activity
C5695_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C5695_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C5695_00915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5695_00945	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5695_00950	COG0489	protein tyrosine kinase activity
C5695_00960	COG2194	sulfuric ester hydrolase activity
C5695_00965	COG0726	polysaccharide deacetylase
C5695_00995	COG0659	secondary active sulfate transmembrane transporter activity
C5695_01000	COG0385	Bile acid
C5695_01005	COG3876	Protein conserved in bacteria
C5695_01010	COG1472	Belongs to the glycosyl hydrolase 3 family
C5695_01015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5695_01020	COG1263	PTS System
C5695_01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_01025	COG1737	Transcriptional regulator
C5695_01030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C5695_01065	COG1595	DNA-templated transcription, initiation
C5695_01070	COG5662	AntiSigma factor
C5695_01075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5695_01080	COG4856	YbbR-like protein
C5695_01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5695_01090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5695_01100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5695_01120	COG1131	(ABC) transporter
C5695_01130	COG1136	(ABC) transporter
C5695_01140	COG1695	Transcriptional regulator
C5695_01150	COG1131	(ABC) transporter
C5695_01160	COG1413	lyase activity
C5695_01165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_01175	COG2311	Membrane
C5695_01195	COG1476	TRANSCRIPTIONal
C5695_01210	COG1113	amino acid transport
C5695_01215	COG0584	glycerophosphoryl diester phosphodiesterase
C5695_01220	COG2271	Major facilitator Superfamily
C5695_01230	COG1331	Highly conserved protein containing a thioredoxin domain
C5695_01250	COG1937	Protein conserved in bacteria
C5695_01255	COG2210	Belongs to the sulfur carrier protein TusA family
C5695_01260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5695_01265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5695_01265	COG0425	Belongs to the sulfur carrier protein TusA family
C5695_01270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5695_01270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5695_01275	COG0425	Belongs to the sulfur carrier protein TusA family
C5695_01280	COG0730	response to heat
C5695_01285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5695_01290	COG2814	Major facilitator Superfamily
C5695_01310	COG1846	Transcriptional regulator
C5695_01320	COG1683	Conserved Protein
C5695_01330	COG0656	L-ascorbic acid biosynthetic process
C5695_01335	COG0371	Dehydrogenase
C5695_01350	COG3711	transcriptional antiterminator
C5695_01355	COG1263	PTS System
C5695_01355	COG2190	(PTS) system
C5695_01355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_01360	COG2723	6-phospho-beta-galactosidase activity
C5695_01380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_01380	COG3711	transcriptional antiterminator
C5695_01390	COG0383	alpha-mannosidase activity
C5695_01395	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_01400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_01405	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_01405	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_01410	COG1404	Belongs to the peptidase S8 family
C5695_01425	COG0833	amino acid
C5695_01430	COG2040	homocysteine
C5695_01435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5695_01455	COG2814	Major facilitator Superfamily
C5695_01475	COG1404	Belongs to the peptidase S8 family
C5695_01485	COG1309	transcriptional regulator
C5695_01490	COG1917	Cupin 2, conserved barrel domain protein
C5695_01495	COG1063	alcohol dehydrogenase
C5695_01500	COG1846	Transcriptional regulator
C5695_01505	COG0318	PFAM AMP-dependent synthetase and ligase
C5695_01510	COG0531	amino acid
C5695_01520	COG0596	Alpha beta hydrolase
C5695_01525	COG1115	amino acid carrier protein
C5695_01530	COG2066	Belongs to the glutaminase family
C5695_01535	COG4191	Histidine kinase
C5695_01540	COG0784	Response regulator, receiver
C5695_01545	COG1405	negative regulation of cell septum assembly
C5695_01545	COG3012	SEC-C Motif Domain Protein
C5695_01555	COG0667	Aldo Keto reductase
C5695_01560	COG3290	protein histidine kinase activity
C5695_01565	COG3279	Response regulator of the LytR AlgR family
C5695_01570	COG4555	ABC transporter
C5695_01575	COG1668	transmembrane transport
C5695_01590	COG3773	Cell wall hydrolase
C5695_01595	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_01605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5695_01610	COG2310	stress, protein
C5695_01615	COG2310	stress, protein
C5695_01620	COG2310	stress, protein
C5695_01625	COG0861	Integral membrane protein TerC family
C5695_01655	COG3853	Toxic anion resistance protein (TelA)
C5695_01660	COG0517	IMP dehydrogenase activity
C5695_01660	COG4175	Glycine betaine
C5695_01665	COG4176	ABC-type proline glycine betaine transport system permease component
C5695_01670	COG2113	Glycine betaine
C5695_01685	COG1473	amidohydrolase
C5695_01690	COG1288	antiporter activity
C5695_01695	COG0039	L-malate dehydrogenase activity
C5695_01700	COG1620	l-lactate permease
C5695_01705	COG1609	Transcriptional regulator
C5695_01710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5695_01715	COG0561	phosphatase activity
C5695_01720	COG0673	inositol 2-dehydrogenase activity
C5695_01725	COG0738	Major facilitator superfamily
C5695_01730	COG1280	lysine exporter protein (LysE YggA)
C5695_01740	COG3403	YqcI/YcgG family
C5695_01745	COG1113	amino acid transport
C5695_01750	COG3665	Urea carboxylase-associated protein
C5695_01755	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C5695_01765	COG1012	belongs to the aldehyde dehydrogenase family
C5695_01770	COG0710	3-dehydroquinate dehydratase activity
C5695_01775	COG0028	Belongs to the TPP enzyme family
C5695_01785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C5695_01790	COG2271	Major facilitator Superfamily
C5695_01800	COG1414	Transcriptional regulator
C5695_01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5695_01810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C5695_01820	COG0477	Major facilitator Superfamily
C5695_01830	COG2226	methyltransferase
C5695_01835	COG0583	DNA-binding transcription factor activity
C5695_01840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5695_01845	COG3458	cephalosporin-C deacetylase activity
C5695_01855	COG3541	Predicted nucleotidyltransferase
C5695_01860	COG0506	proline dehydrogenase activity
C5695_01865	COG1012	belongs to the aldehyde dehydrogenase family
C5695_01870	COG2508	Transcriptional regulator
C5695_01875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5695_01880	COG0765	amino acid transport
C5695_01885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_01895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5695_01900	COG1522	sequence-specific DNA binding
C5695_01905	COG2746	aminoglycoside 3-N-acetyltransferase activity
C5695_01915	COG3290	protein histidine kinase activity
C5695_01915	COG0840	transmembrane signaling receptor activity
C5695_01920	COG3209	COG3209 Rhs family protein
C5695_01945	COG3842	ATPase activity
C5695_01950	COG1176	ABC-type spermidine putrescine transport system, permease component I
C5695_01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5695_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5695_01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5695_01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C5695_01990	COG0697	spore germination
C5695_01995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5695_02005	COG2364	Membrane
C5695_02010	COG1126	abc transporter atp-binding protein
C5695_02015	COG0765	amino acid transport
C5695_02020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_02025	COG0833	amino acid
C5695_02035	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_02040	COG1312	Catalyzes the dehydration of D-mannonate
C5695_02045	COG1802	Transcriptional regulator
C5695_02050	COG0673	inositol 2-dehydrogenase activity
C5695_02060	COG1904	glucuronate isomerase
C5695_02065	COG3104	oligopeptide transport
C5695_02070	COG5434	Belongs to the glycosyl hydrolase 28 family
C5695_02085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_02090	COG0765	amino acid transport
C5695_02095	COG1126	abc transporter atp-binding protein
C5695_02105	COG2079	MmgE PrpD family protein
C5695_02110	COG0745	RESPONSE REGULATOR receiver
C5695_02115	COG3850	Histidine kinase
C5695_02115	COG5002	protein histidine kinase activity
C5695_02120	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_02125	COG0527	aspartate kinase activity
C5695_02130	COG2814	Major facilitator Superfamily
C5695_02135	COG1309	transcriptional regulator
C5695_02145	COG0640	Transcriptional regulator
C5695_02150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5695_02155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C5695_02160	COG0531	amino acid
C5695_02165	COG1012	belongs to the aldehyde dehydrogenase family
C5695_02170	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5695_02175	COG4549	nuclear export factor GLE1
C5695_02180	COG2372	response to copper ion
C5695_02180	COG1276	copper resistance
C5695_02185	COG2213	PTS system mannitol-specific
C5695_02190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_02195	COG0246	Mannitol dehydrogenase
C5695_02200	COG0840	transmembrane signaling receptor activity
C5695_02220	COG0346	lactoylglutathione lyase activity
C5695_02230	COG0561	phosphatase activity
C5695_02235	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C5695_02240	COG1914	H( )-stimulated, divalent metal cation uptake system
C5695_02245	COG4336	lyase activity
C5695_02250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C5695_02255	COG1984	allophanate hydrolase subunit 2
C5695_02260	COG1414	Transcriptional regulator
C5695_02265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5695_02270	COG2755	lipolytic protein G-D-S-L family
C5695_02280	COG3711	transcriptional antiterminator
C5695_02285	COG2226	methyltransferase
C5695_02290	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_02295	COG3871	stress protein (general stress protein 26)
C5695_02315	COG2814	Major facilitator Superfamily
C5695_02320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5695_02320	COG0551	DNA topoisomerase type I activity
C5695_02325	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C5695_02330	COG3706	GGDEF domain
C5695_02335	COG5298	Protein conserved in bacteria
C5695_02340	COG1215	transferase activity, transferring glycosyl groups
C5695_02350	COG0531	amino acid
C5695_02355	COG0028	Belongs to the TPP enzyme family
C5695_02380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5695_02385	COG1914	H( )-stimulated, divalent metal cation uptake system
C5695_02390	COG2261	transglycosylase associated protein
C5695_02395	COG2217	Heavy metal translocating P-type atpase
C5695_02400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C5695_02405	COG3290	protein histidine kinase activity
C5695_02410	COG4565	transcriptional regulatory protein
C5695_02415	COG1301	dicarboxylic acid transport
C5695_02420	COG0628	permease
C5695_02425	COG1301	dicarboxylic acid transport
C5695_02430	COG1131	(ABC) transporter
C5695_02435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C5695_02450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_02455	COG1181	Belongs to the D-alanine--D-alanine ligase family
C5695_02460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5695_02475	COG0513	Belongs to the DEAD box helicase family
C5695_02480	COG3402	PFAM membrane-flanked domain
C5695_02485	COG3428	Bacterial PH domain
C5695_02490	COG0705	Rhomboid family
C5695_02495	COG0736	holo-[acyl-carrier-protein] synthase activity
C5695_02500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C5695_02505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5695_02510	COG0864	Transcriptional regulator
C5695_02515	COG2337	Toxic component of a toxin-antitoxin (TA) module
C5695_02520	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_02525	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_02530	COG2172	sigma factor antagonist activity
C5695_02535	COG2208	phosphoserine phosphatase activity
C5695_02540	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_02545	COG2172	sigma factor antagonist activity
C5695_02550	COG1191	sigma factor activity
C5695_02555	COG2208	phosphoserine phosphatase activity
C5695_02560	COG2183	response to ionizing radiation
C5695_02570	COG3091	SprT-like family
C5695_02575	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5695_02580	COG0022	dehydrogenase e1 component
C5695_02585	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5695_02590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5695_02595	COG3284	Transcriptional regulator
C5695_02640	COG1278	Cold shock
C5695_02645	COG1329	Transcriptional regulator
C5695_02650	COG1064	alcohol dehydrogenase
C5695_02655	COG0789	Transcriptional regulator
C5695_02670	COG0477	Major facilitator Superfamily
C5695_02710	COG0252	asparaginase activity
C5695_02730	COG2814	Major facilitator Superfamily
C5695_02735	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C5695_02740	COG2409	Drug exporters of the RND superfamily
C5695_02745	COG4585	Histidine kinase
C5695_02750	COG2197	response regulator
C5695_02795	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5695_02800	COG1846	Transcriptional regulator
C5695_02805	COG0778	Nitroreductase
C5695_02820	COG1396	sequence-specific DNA binding
C5695_02830	COG0456	acetyltransferase
C5695_02835	COG0583	DNA-binding transcription factor activity
C5695_02840	COG0667	Aldo Keto reductase
C5695_02850	COG4122	O-methyltransferase activity
C5695_02860	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C5695_02865	COG0697	spore germination
C5695_02875	COG1301	dicarboxylic acid transport
C5695_02920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5695_02925	COG0802	atpase or kinase
C5695_02930	COG1214	PFAM Peptidase M22, glycoprotease
C5695_02935	COG0456	acetyltransferase
C5695_02940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C5695_02945	COG0488	(ABC) transporter
C5695_02950	COG0315	cyclic pyranopterin monophosphate synthase activity
C5695_02955	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C5695_02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C5695_02965	COG0805	protein transport
C5695_02980	COG1266	CAAX protease self-immunity
C5695_02985	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C5695_02990	COG0459	protein refolding
C5695_03020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C5695_03025	COG0823	Involved in the tonB-independent uptake of proteins
C5695_03035	COG2132	Multicopper oxidase
C5695_03040	COG1113	amino acid transport
C5695_03045	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5695_03050	COG0714	Associated with various cellular activities
C5695_03055	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C5695_03060	COG1305	Transglutaminase-like
C5695_03065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C5695_03065	COG0519	Catalyzes the synthesis of GMP from XMP
C5695_03070	COG2207	Transcriptional regulator
C5695_03080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5695_03120	COG2814	Major facilitator Superfamily
C5695_03125	COG0583	DNA-binding transcription factor activity
C5695_03130	COG2252	PERMEase
C5695_03135	COG3064	Membrane
C5695_03140	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C5695_03150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C5695_03155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C5695_03160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5695_03165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C5695_03170	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5695_03175	COG0047	phosphoribosylformylglycinamidine synthase activity
C5695_03180	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C5695_03185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C5695_03190	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C5695_03195	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C5695_03200	COG0138	bifunctional purine biosynthesis protein purh
C5695_03205	COG0151	Belongs to the GarS family
C5695_03225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5695_03230	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C5695_03235	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C5695_03240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5695_03250	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5695_03255	COG4496	protein, YerC YecD
C5695_03260	COG0069	glutamate synthase activity
C5695_03275	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C5695_03280	COG0210	DNA helicase
C5695_03285	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C5695_03290	COG4851	CamS sex pheromone cAM373 precursor
C5695_03305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C5695_03320	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5695_03335	COG1960	acyl-CoA dehydrogenase activity
C5695_03345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5695_03355	COG0300	oxidoreductase activity
C5695_03355	COG4221	oxidoreductase activity
C5695_03355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5695_03355	COG3321	synthase
C5695_03365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5695_03370	COG1785	Belongs to the alkaline phosphatase family
C5695_03375	COG1285	pathogenesis
C5695_03380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5695_03385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5695_03390	COG0154	amidase activity
C5695_03395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C5695_03400	COG1309	transcriptional regulator
C5695_03405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5695_03410	COG1957	nucleoside hydrolase
C5695_03415	COG1597	lipid kinase activity
C5695_03420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5695_03425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C5695_03440	COG1959	2 iron, 2 sulfur cluster binding
C5695_03445	COG0492	ferredoxin-NADP+ reductase activity
C5695_03460	COG1486	melibiose metabolic process
C5695_03500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C5695_03505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5695_03510	COG1442	glycosyl transferase family 8
C5695_03515	COG1216	Glycosyl transferase, family 2
C5695_03520	COG1442	glycosyl transferase family 8
C5695_03525	COG2223	nitrite transmembrane transporter activity
C5695_03535	COG0471	metal ion transport
C5695_03560	COG0531	amino acid
C5695_03565	COG0463	Glycosyl transferase, family 2
C5695_03570	COG0488	(ABC) transporter
C5695_03575	COG1469	GTP cyclohydrolase I activity
C5695_03580	COG0789	Transcriptional regulator
C5695_03585	COG2814	Major facilitator Superfamily
C5695_03590	COG0488	(ABC) transporter
C5695_03595	COG0513	Belongs to the DEAD box helicase family
C5695_03600	COG2130	NADP-dependent
C5695_03620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5695_03620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5695_03635	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5695_03635	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5695_03645	COG3290	protein histidine kinase activity
C5695_03650	COG4565	transcriptional regulatory protein
C5695_03655	COG3181	Tripartite tricarboxylate transporter family receptor
C5695_03660	COG2851	Citrate transporter
C5695_03670	COG3479	Phenolic acid decarboxylase
C5695_03675	COG1695	Transcriptional regulator
C5695_03680	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C5695_03685	COG1254	Belongs to the acylphosphatase family
C5695_03690	COG2258	MOSC domain
C5695_03700	COG0024	Methionine aminopeptidase
C5695_03705	COG1263	PTS System
C5695_03705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_03710	COG3739	integral membrane protein
C5695_03725	COG1368	sulfuric ester hydrolase activity
C5695_03730	COG0076	glutamate decarboxylase activity
C5695_03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_03745	COG1263	PTS System
C5695_03750	COG0366	Alpha amylase catalytic
C5695_03755	COG2188	Transcriptional regulator
C5695_03765	COG0737	Belongs to the 5'-nucleotidase family
C5695_03770	COG0693	protein deglycase activity
C5695_03775	COG4840	Belongs to the UPF0435 family
C5695_03780	COG1115	amino acid carrier protein
C5695_03790	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5695_03795	COG4980	gas vesicle protein
C5695_03800	COG1295	ribonuclease BN
C5695_03805	COG0477	Major facilitator Superfamily
C5695_03815	COG0387	Pfam Sodium calcium exchanger
C5695_03825	COG0217	transcriptional regulatory protein
C5695_03835	COG0668	transmembrane transport
C5695_03840	COG0535	radical SAM domain protein
C5695_03850	COG0726	polysaccharide deacetylase
C5695_03860	COG0598	Magnesium transport protein CorA
C5695_03870	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C5695_03875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C5695_03890	COG0583	DNA-binding transcription factor activity
C5695_03895	COG1942	4-Oxalocrotonate Tautomerase
C5695_03910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5695_03955	COG2076	Multidrug Resistance protein
C5695_03960	COG2076	Multidrug Resistance protein
C5695_03965	COG1309	transcriptional regulator
C5695_03975	COG4637	Psort location Cytoplasmic, score
C5695_03980	COG2755	lipolytic protein G-D-S-L family
C5695_03985	COG0492	ferredoxin-NADP+ reductase activity
C5695_03990	COG0662	Cupin 2, conserved barrel domain protein
C5695_03990	COG2207	Transcriptional regulator
C5695_03995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_04000	COG1132	(ABC) transporter
C5695_04005	COG1742	UPF0060 membrane protein
C5695_04010	COG1595	DNA-templated transcription, initiation
C5695_04045	COG1846	Transcriptional regulator
C5695_04050	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C5695_04050	COG0392	lysyltransferase activity
C5695_04075	COG0778	Nitroreductase
C5695_04090	COG1090	epimerase
C5695_04095	COG2137	regulation of response to DNA damage stimulus
C5695_04120	COG0463	Glycosyl transferase, family 2
C5695_04125	COG4485	Bacterial membrane protein, YfhO
C5695_04135	COG2140	Oxalate decarboxylase
C5695_04145	COG1191	sigma factor activity
C5695_04155	COG1988	membrane-bound metal-dependent
C5695_04160	COG1194	a g-specific adenine glycosylase
C5695_04170	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_04185	COG3557	Belongs to the UPF0374 family
C5695_04190	COG1132	(ABC) transporter
C5695_04195	COG0444	Belongs to the ABC transporter superfamily
C5695_04200	COG4608	Belongs to the ABC transporter superfamily
C5695_04205	COG0747	negative chemotaxis
C5695_04225	COG4129	membrane
C5695_04230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5695_04235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C5695_04240	COG0735	belongs to the Fur family
C5695_04390	COG1368	sulfuric ester hydrolase activity
C5695_04395	COG0681	Belongs to the peptidase S26 family
C5695_04410	COG1131	(ABC) transporter
C5695_04440	COG3382	B3 4 domain protein
C5695_04445	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C5695_04455	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C5695_04460	COG2766	serine protein kinase
C5695_04470	COG1566	PFAM secretion protein HlyD family protein
C5695_04475	COG2814	Major facilitator Superfamily
C5695_04480	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5695_04490	COG1278	Cold shock
C5695_04500	COG3706	GGDEF domain
C5695_04525	COG5577	PFAM Coat F domain
C5695_04530	COG5002	protein histidine kinase activity
C5695_04535	COG0737	Belongs to the 5'-nucleotidase family
C5695_04535	COG1525	nuclease
C5695_04535	COG4085	toxin activity
C5695_04540	COG3764	Sortase (surface protein transpeptidase)
C5695_04545	COG0564	pseudouridine synthase activity
C5695_04555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C5695_04560	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C5695_04560	COG3153	acetyltransferase
C5695_04580	COG3835	regulator
C5695_04585	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5695_04590	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C5695_04595	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5695_04600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C5695_04605	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C5695_04610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C5695_04615	COG4585	Histidine kinase
C5695_04615	COG2203	Gaf domain
C5695_04620	COG2197	response regulator
C5695_04640	COG0753	catalase activity
C5695_04645	COG1959	2 iron, 2 sulfur cluster binding
C5695_04650	COG1017	nitric oxide dioxygenase activity
C5695_04650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5695_04655	COG2719	SpoVR family
C5695_04660	COG1785	Belongs to the alkaline phosphatase family
C5695_04665	COG0791	NLP P60 protein
C5695_04665	COG1388	LysM domain
C5695_04680	COG1595	DNA-templated transcription, initiation
C5695_04685	COG0204	Acyl-transferase
C5695_04690	COG1253	flavin adenine dinucleotide binding
C5695_04695	COG0789	Transcriptional regulator
C5695_04700	COG1253	flavin adenine dinucleotide binding
C5695_04710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5695_04715	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C5695_04720	COG0584	glycerophosphoryl diester phosphodiesterase
C5695_04730	COG0668	transmembrane transport
C5695_04735	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C5695_04740	COG0726	polysaccharide deacetylase
C5695_04745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5695_04750	COG0589	response to stress
C5695_04755	COG1132	(ABC) transporter
C5695_04760	COG1132	(ABC) transporter
C5695_04765	COG0702	epimerase
C5695_04775	COG3842	ATPase activity
C5695_04780	COG2508	Transcriptional regulator
C5695_04790	COG0189	ligase activity
C5695_04795	COG0189	ligase activity
C5695_04800	COG4399	Belongs to the UPF0754 family
C5695_04805	COG3679	Belongs to the UPF0342 family
C5695_04810	COG0561	phosphatase activity
C5695_04815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5695_04825	COG0475	glutathione-regulated potassium exporter activity
C5695_04830	COG0490	domain, Protein
C5695_04840	COG1024	Enoyl-CoA hydratase
C5695_04850	COG0420	3'-5' exonuclease activity
C5695_04855	COG4717	serine-type aminopeptidase activity
C5695_04860	COG3481	metal-dependent phosphohydrolase, HD sub domain
C5695_04870	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5695_04900	COG1846	Transcriptional regulator
C5695_04905	COG4980	gas vesicle protein
C5695_04920	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C5695_04930	COG0537	adenosine 5'-monophosphoramidase activity
C5695_04935	COG1131	(ABC) transporter
C5695_04940	COG4473	ABC transporter
C5695_04955	COG1473	amidohydrolase
C5695_04965	COG2329	Antibiotic biosynthesis monooxygenase
C5695_04970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5695_04975	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C5695_04990	COG1309	transcriptional regulator
C5695_04995	COG1511	domain protein
C5695_05000	COG1363	Peptidase, m42
C5695_05005	COG1301	dicarboxylic acid transport
C5695_05015	COG1234	tRNA 3'-trailer cleavage
C5695_05020	COG0095	Lipoate-protein ligase
C5695_05025	COG0318	PFAM AMP-dependent synthetase and ligase
C5695_05035	COG0501	Belongs to the peptidase M48B family
C5695_05040	COG1404	Belongs to the peptidase S8 family
C5695_05045	COG0406	alpha-ribazole phosphatase activity
C5695_05050	COG0840	transmembrane signaling receptor activity
C5695_05055	COG0723	plastoquinol--plastocyanin reductase activity
C5695_05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C5695_05060	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_05070	COG4903	ComK protein
C5695_05075	COG4974	Belongs to the 'phage' integrase family
C5695_05080	COG2856	Zn peptidase
C5695_05090	COG3620	sequence-specific DNA binding
C5695_05095	COG1396	sequence-specific DNA binding
C5695_05160	COG1484	DNA-dependent DNA replication
C5695_05225	COG3677	Transposase
C5695_05240	COG5484	DNA packaging
C5695_05400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5695_05405	COG2814	Major facilitator Superfamily
C5695_05410	COG2732	(Barnase) inhibitor
C5695_05415	COG1316	TRANSCRIPTIONal
C5695_05425	COG0398	Pfam SNARE associated Golgi protein
C5695_05430	COG0681	Belongs to the peptidase S26 family
C5695_05435	COG3180	Ammonia monooxygenase
C5695_05440	COG0582	viral genome integration into host DNA
C5695_05445	COG2856	Zn peptidase
C5695_05450	COG1396	sequence-specific DNA binding
C5695_05475	COG1674	ftsk spoiiie
C5695_05480	COG2946	Replication initiation factor
C5695_05570	COG0433	COG0433 Predicted ATPase
C5695_05575	COG5644	endopeptidase inhibitor activity
C5695_05580	COG0791	NLP P60 protein
C5695_05580	COG0741	lytic transglycosylase activity
C5695_05595	COG0457	Tetratricopeptide repeat
C5695_05605	COG0501	Belongs to the peptidase M48B family
C5695_05610	COG2259	Doxx family
C5695_05615	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C5695_05620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C5695_05625	COG1074	ATP-dependent DNA helicase activity
C5695_05630	COG0420	3'-5' exonuclease activity
C5695_05635	COG0419	ATPase involved in DNA repair
C5695_05640	COG1403	HNH endonuclease
C5695_05680	COG5337	Spore coat protein CotH
C5695_05690	COG0179	Fumarylacetoacetate (FAA) hydrolase
C5695_05705	COG0367	asparagine synthase
C5695_05720	COG1562	ergosterol biosynthetic process
C5695_05730	COG0534	Mate efflux family protein
C5695_05735	COG1917	Cupin 2, conserved barrel domain protein
C5695_05735	COG2207	Transcriptional regulator
C5695_05760	COG0076	glutamate decarboxylase activity
C5695_05790	COG0646	methionine synthase
C5695_05790	COG1410	methionine synthase
C5695_05795	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5695_05795	COG0646	methionine synthase
C5695_05800	COG1666	GTP binding
C5695_05805	COG2996	Protein conserved in bacteria
C5695_05815	COG0840	transmembrane signaling receptor activity
C5695_05820	COG1307	EDD domain protein, DegV family
C5695_05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5695_05850	COG0561	phosphatase activity
C5695_05855	COG1073	alpha beta
C5695_05860	COG2151	metal-sulfur cluster biosynthetic enzyme
C5695_05870	COG2271	Major facilitator Superfamily
C5695_05875	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C5695_05885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5695_05890	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5695_05895	COG0505	Belongs to the CarA family
C5695_05900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5695_05905	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C5695_05915	COG2814	Major facilitator Superfamily
C5695_05925	COG2267	carboxylic ester hydrolase activity
C5695_05935	COG1744	ABC transporter substrate-binding protein PnrA-like
C5695_05950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5695_05955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5695_05960	COG5504	Zn-dependent protease
C5695_05965	COG0444	Belongs to the ABC transporter superfamily
C5695_05970	COG4608	Belongs to the ABC transporter superfamily
C5695_05980	COG0601	transmembrane transport
C5695_05985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5695_05995	COG0180	Tryptophanyl-tRNA synthetase
C5695_06005	COG4166	transmembrane transport
C5695_06010	COG0601	transmembrane transport
C5695_06015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5695_06020	COG0444	Belongs to the ABC transporter superfamily
C5695_06025	COG4608	Belongs to the ABC transporter superfamily
C5695_06035	COG0456	acetyltransferase
C5695_06040	COG1393	Belongs to the ArsC family
C5695_06045	COG0861	Integral membrane protein TerC family
C5695_06050	COG4862	establishment of competence for transformation
C5695_06055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5695_06065	COG1164	Oligoendopeptidase f
C5695_06080	COG2346	COG2346, Truncated hemoglobins
C5695_06085	COG0741	lytic transglycosylase activity
C5695_06090	COG4116	CYTH
C5695_06100	COG2357	RelA SpoT domain protein
C5695_06105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5695_06110	COG0564	pseudouridine synthase activity
C5695_06120	COG0569	domain protein
C5695_06120	COG0475	glutathione-regulated potassium exporter activity
C5695_06125	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C5695_06130	COG0352	thiamine-phosphate diphosphorylase activity
C5695_06140	COG2104	thiamine diphosphate biosynthetic process
C5695_06145	COG2022	thiamine diphosphate biosynthetic process
C5695_06150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5695_06155	COG0351	phosphomethylpyrimidine kinase
C5695_06160	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5695_06215	COG0210	DNA helicase
C5695_06225	COG2153	protein acetylation
C5695_06230	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5695_06235	COG2382	esterase
C5695_06240	COG0626	cystathionine gamma-synthase activity
C5695_06245	COG0626	cystathionine gamma-synthase activity
C5695_06280	COG0457	Tetratricopeptide repeat
C5695_06310	COG0583	DNA-binding transcription factor activity
C5695_06330	COG0457	Tetratricopeptide repeat
C5695_06350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C5695_06360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5695_06365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5695_06370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5695_06385	COG4195	phage-related replication protein
C5695_06390	COG2856	Zn peptidase
C5695_06395	COG3409	Peptidoglycan-binding domain 1 protein
C5695_06395	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5695_06410	COG0306	phosphate transporter
C5695_06415	COG1392	Phosphate transport regulator
C5695_06425	COG0405	Gamma-glutamyltransferase
C5695_06435	COG3775	system Galactitol-specific IIC component
C5695_06450	COG1063	alcohol dehydrogenase
C5695_06455	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5695_06460	COG0022	dehydrogenase e1 component
C5695_06460	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5695_06465	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5695_06470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5695_06475	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_06485	COG2390	Transcriptional regulator
C5695_06495	COG0531	amino acid
C5695_06500	COG0346	lactoylglutathione lyase activity
C5695_06505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5695_06510	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5695_06515	COG2362	D-Aminopeptidase
C5695_06520	COG0601	transmembrane transport
C5695_06525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5695_06530	COG0444	Belongs to the ABC transporter superfamily
C5695_06535	COG4166	transmembrane transport
C5695_06540	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5695_06545	COG4948	Mandelate Racemase Muconate Lactonizing
C5695_06550	COG0791	NLP P60 protein
C5695_06555	COG4608	Belongs to the ABC transporter superfamily
C5695_06560	COG1834	amidinotransferase
C5695_06565	COG1607	acyl-coa hydrolase
C5695_06570	COG1695	Transcriptional regulator
C5695_06585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5695_06600	COG2076	Multidrug Resistance protein
C5695_06605	COG2076	Multidrug Resistance protein
C5695_06615	COG0788	formyltetrahydrofolate deformylase activity
C5695_06620	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5695_06625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5695_06630	COG0457	Tetratricopeptide repeat
C5695_06640	COG1764	response to oxidative stress
C5695_06645	COG1846	Transcriptional regulator
C5695_06650	COG1764	response to oxidative stress
C5695_06660	COG0590	tRNA wobble adenosine to inosine editing
C5695_06665	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5695_06670	COG1404	Belongs to the peptidase S8 family
C5695_06685	COG0745	RESPONSE REGULATOR receiver
C5695_06690	COG3850	Histidine kinase
C5695_06690	COG5002	protein histidine kinase activity
C5695_06695	COG3212	peptidase
C5695_06700	COG3212	peptidase
C5695_06710	COG2239	Acts as a magnesium transporter
C5695_06720	COG0583	DNA-binding transcription factor activity
C5695_06730	COG0789	Transcriptional regulator
C5695_06740	COG1846	Transcriptional regulator
C5695_06745	COG3300	MHYT domain
C5695_06745	COG5001	Diguanylate cyclase
C5695_06750	COG0586	Pfam SNARE associated Golgi protein
C5695_06755	COG0861	Integral membrane protein TerC family
C5695_06760	COG1191	sigma factor activity
C5695_06785	COG0501	Belongs to the peptidase M48B family
C5695_06790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5695_06800	COG2323	membrane
C5695_06810	COG3594	Acyltransferase
C5695_06815	COG5002	protein histidine kinase activity
C5695_06820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C5695_06825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C5695_06830	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C5695_06835	COG0436	Aminotransferase
C5695_06840	COG1850	ribulose-bisphosphate carboxylase activity
C5695_06845	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C5695_06850	COG0235	Class ii aldolase
C5695_06855	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C5695_06865	COG3852	Histidine kinase
C5695_06870	COG1846	Transcriptional regulator
C5695_06875	COG1360	Flagellar Motor Protein
C5695_06880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C5695_06885	COG0542	response to heat
C5695_06890	COG3949	Membrane
C5695_06895	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C5695_06900	COG0720	synthase
C5695_06905	COG0602	queuosine metabolic process
C5695_06910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C5695_06925	COG4873	Protein conserved in bacteria
C5695_06935	COG3773	Cell wall hydrolase
C5695_06940	COG2244	polysaccharide biosynthetic process
C5695_06945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_06950	COG2217	Heavy metal translocating P-type atpase
C5695_06955	COG0006	proline dipeptidase activity
C5695_06960	COG1609	Transcriptional regulator
C5695_06965	COG3711	transcriptional antiterminator
C5695_06970	COG1263	PTS System
C5695_06970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_06970	COG2190	(PTS) system
C5695_06975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_06980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5695_06990	COG1533	DNA photolyase activity
C5695_06995	COG0840	transmembrane signaling receptor activity
C5695_07005	COG2084	Dehydrogenase
C5695_07010	COG2340	Cysteine-rich secretory protein family
C5695_07015	COG0768	penicillin binding
C5695_07020	COG4191	Histidine kinase
C5695_07025	COG0436	Aminotransferase
C5695_07030	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C5695_07035	COG1714	RDD family
C5695_07045	COG0835	chemotaxis
C5695_07045	COG0784	Response regulator, receiver
C5695_07060	COG2814	Major facilitator Superfamily
C5695_07065	COG1376	ErfK ybiS ycfS ynhG family protein
C5695_07070	COG1408	metallophosphoesterase
C5695_07075	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_07080	COG2200	EAL domain
C5695_07085	COG3546	catalase activity
C5695_07090	COG4703	Protein of unknown function (DUF1797)
C5695_07095	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C5695_07105	COG0517	IMP dehydrogenase activity
C5695_07110	COG0583	DNA-binding transcription factor activity
C5695_07120	COG0716	FMN binding
C5695_07130	COG0716	FMN binding
C5695_07135	COG2171	N-acyltransferase activity
C5695_07140	COG1473	amidohydrolase
C5695_07150	COG0668	transmembrane transport
C5695_07155	COG0450	alkyl hydroperoxide reductase
C5695_07160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_07175	COG0746	molybdenum cofactor guanylyltransferase activity
C5695_07180	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C5695_07185	COG0303	'Molybdopterin
C5695_07190	COG1763	Mo-molybdopterin cofactor biosynthetic process
C5695_07195	COG0314	molybdopterin synthase activity
C5695_07200	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C5695_07215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C5695_07220	COG1136	(ABC) transporter
C5695_07225	COG0577	efflux transmembrane transporter activity
C5695_07230	COG1349	DNA-binding transcription factor activity
C5695_07235	COG1105	Belongs to the carbohydrate kinase PfkB family
C5695_07240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_07240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_07240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_07245	COG0681	Belongs to the peptidase S26 family
C5695_07255	COG0488	(ABC) transporter
C5695_07260	COG2309	aminopeptidase activity
C5695_07265	COG1077	Cell shape determining protein MreB Mrl
C5695_07270	COG2002	toxin-antitoxin pair type II binding
C5695_07275	COG3852	Histidine kinase
C5695_07280	COG2105	PFAM AIG2 family protein
C5695_07280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C5695_07285	COG0569	domain protein
C5695_07290	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C5695_07295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5695_07305	COG0561	phosphatase activity
C5695_07310	COG0242	peptide deformylase activity
C5695_07325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5695_07330	COG0022	dehydrogenase e1 component
C5695_07335	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5695_07340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5695_07345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_07360	COG1982	Orn Lys Arg decarboxylase major
C5695_07365	COG4476	Belongs to the UPF0223 family
C5695_07375	COG4493	Belongs to the UPF0637 family
C5695_07385	COG0483	inositol monophosphate 1-phosphatase activity
C5695_07420	COG4896	Protein conserved in bacteria
C5695_07430	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C5695_07435	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C5695_07440	COG2066	Belongs to the glutaminase family
C5695_07445	COG4838	Belongs to the UPF0358 family
C5695_07450	COG0772	Belongs to the SEDS family
C5695_07455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C5695_07470	COG1612	heme a metabolic process
C5695_07475	COG0109	protoheme IX farnesyltransferase activity
C5695_07480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5695_07480	COG2010	Cytochrome c
C5695_07485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5695_07490	COG1845	cytochrome c oxidase, subunit III
C5695_07495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5695_07500	COG3336	cytochrome c oxidase
C5695_07510	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C5695_07515	COG2340	Cysteine-rich secretory protein family
C5695_07535	COG3679	Belongs to the UPF0342 family
C5695_07540	COG4471	UPF0298 protein
C5695_07545	COG0742	ribosomal rna small subunit methyltransferase
C5695_07550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C5695_07555	COG3314	Sporulation integral membrane protein YlbJ
C5695_07560	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5695_07565	COG3480	Lon protease (S16) C-terminal proteolytic domain
C5695_07585	COG1399	metal-binding, possibly nucleic acid-binding protein
C5695_07590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C5695_07600	COG0454	-acetyltransferase
C5695_07605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C5695_07610	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C5695_07615	COG2001	Belongs to the MraZ family
C5695_07620	COG0275	rRNA processing
C5695_07625	COG4839	cell division protein FtsL
C5695_07640	COG0768	penicillin binding
C5695_07650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5695_07655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5695_07660	COG0772	Belongs to the SEDS family
C5695_07665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5695_07670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5695_07675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C5695_07680	COG3879	Bacterial protein of unknown function (DUF881)
C5695_07685	COG3879	Bacterial protein of unknown function (DUF881)
C5695_07690	COG3856	small basic protein
C5695_07695	COG0849	cell division
C5695_07700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5695_07705	COG4412	M6 family metalloprotease domain protein
C5695_07705	COG1404	Belongs to the peptidase S8 family
C5695_07715	COG1191	sigma factor activity
C5695_07720	COG1191	sigma factor activity
C5695_07725	COG2390	Transcriptional regulator
C5695_07740	COG3730	PTS system glucitol sorbitol-specific
C5695_07745	COG3732	PTS system glucitol sorbitol-specific
C5695_07755	COG1119	ATPase activity
C5695_07760	COG1873	PFAM PRC-barrel domain
C5695_07770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5695_07775	COG1799	cell septum assembly
C5695_07780	COG0762	integral membrane protein
C5695_07785	COG2302	S4 RNA-binding domain
C5695_07790	COG3599	regulation of cell shape
C5695_07795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C5695_07800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5695_07805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C5695_07810	COG0564	pseudouridine synthase activity
C5695_07815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C5695_07820	COG2233	PERMEase
C5695_07825	COG0540	Belongs to the ATCase OTCase family
C5695_07830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C5695_07835	COG0505	Belongs to the CarA family
C5695_07840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5695_07845	COG0543	2 iron, 2 sulfur cluster binding
C5695_07850	COG0167	dihydroorotate dehydrogenase activity
C5695_07855	COG0284	orotidine-5'-phosphate decarboxylase activity
C5695_07860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C5695_07865	COG0175	sulfate reduction
C5695_07870	COG0306	phosphate transporter
C5695_07875	COG2046	Belongs to the sulfate adenylyltransferase family
C5695_07880	COG0529	Catalyzes the synthesis of activated sulfate
C5695_07885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5695_07890	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C5695_07895	COG1648	precorrin-2 dehydrogenase activity
C5695_07905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C5695_07910	COG1561	YicC-like family, N-terminal region
C5695_07915	COG2052	Domain of unknown function (DUF370)
C5695_07920	COG0194	GDP metabolic process
C5695_07925	COG1758	RNA polymerase activity
C5695_07930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5695_07935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5695_07940	COG0242	peptide deformylase activity
C5695_07945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C5695_07950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5695_07950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C5695_07955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5695_07960	COG0631	protein serine/threonine phosphatase activity
C5695_07965	COG0515	serine threonine protein kinase
C5695_07965	COG2815	serine threonine protein kinase
C5695_07970	COG1162	GTPase activity
C5695_07975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5695_07980	COG1564	THIamine pyrophosphokinase
C5695_07990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C5695_07995	COG1302	Protein conserved in bacteria
C5695_08000	COG1461	Dihydroxyacetone kinase
C5695_08005	COG1760	l-serine dehydratase
C5695_08010	COG1760	l-serine dehydratase
C5695_08015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C5695_08020	COG1349	DNA-binding transcription factor activity
C5695_08025	COG0416	fatty acid biosynthetic process
C5695_08030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5695_08035	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_08040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5695_08050	COG1196	nuclear chromosome segregation
C5695_08055	COG0552	protein localization to endoplasmic reticulum
C5695_08060	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C5695_08065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5695_08070	COG0228	four-way junction DNA binding
C5695_08075	COG1837	Belongs to the UPF0109 family
C5695_08085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5695_08090	COG0336	Belongs to the RNA methyltransferase TrmD family
C5695_08095	COG0335	large ribosomal subunit rRNA binding
C5695_08100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C5695_08105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5695_08115	COG2257	FlhB HrpN YscU SpaS Family
C5695_08120	COG0045	succinate-CoA ligase (ADP-forming) activity
C5695_08125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C5695_08130	COG0758	DNA mediated transformation
C5695_08135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5695_08140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C5695_08145	COG4974	Belongs to the 'phage' integrase family
C5695_08150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5695_08155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C5695_08160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C5695_08165	COG1815	bacterial-type flagellum-dependent cell motility
C5695_08170	COG1558	bacterial-type flagellum-dependent cell motility
C5695_08175	COG1677	Flagellar hook-basal body complex protein FliE
C5695_08180	COG1766	The M ring may be actively involved in energy transduction
C5695_08185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5695_08190	COG1317	bacterial-type flagellum organization
C5695_08195	COG1157	protein secretion by the type III secretion system
C5695_08200	COG2882	bacterial-type flagellum organization
C5695_08205	COG3334	PFAM MgtE intracellular
C5695_08210	COG3144	bacterial-type flagellum assembly
C5695_08215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5695_08220	COG4786	Flagellar basal body rod
C5695_08225	COG1582	Flagellar protein (FlbD)
C5695_08230	COG1580	Controls the rotational direction of flagella during chemotaxis
C5695_08235	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5695_08240	COG1776	CheC inhibitor of MCP methylation
C5695_08240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5695_08245	COG2201	protein-glutamate methylesterase activity
C5695_08250	COG3190	flagellar
C5695_08255	COG1338	Plays a role in the flagellum-specific transport system
C5695_08260	COG1987	bacterial-type flagellum assembly
C5695_08265	COG1684	flagellar biosynthetic protein fliR
C5695_08270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5695_08275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5695_08280	COG1419	protein localization to endoplasmic reticulum
C5695_08285	COG0455	bacterial-type flagellum organization
C5695_08290	COG2201	protein-glutamate methylesterase activity
C5695_08295	COG0643	Histidine kinase
C5695_08295	COG2198	Histidine kinase
C5695_08300	COG0835	chemotaxis
C5695_08305	COG1776	CheC inhibitor of MCP methylation
C5695_08315	COG1191	sigma factor activity
C5695_08330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C5695_08335	COG0528	UMP kinase activity
C5695_08340	COG0233	cytoplasmic translational termination
C5695_08345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5695_08350	COG4589	Belongs to the CDS family
C5695_08355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C5695_08360	COG0750	zinc metalloprotease
C5695_08365	COG0442	prolyl-tRNA aminoacylation
C5695_08370	COG2176	DNA-directed DNA polymerase activity
C5695_08395	COG0779	Required for maturation of 30S ribosomal subunits
C5695_08400	COG0195	Participates in both transcription termination and antitermination
C5695_08405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C5695_08410	COG1358	cellular component organization or biogenesis
C5695_08415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C5695_08420	COG1550	Protein conserved in bacteria
C5695_08425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C5695_08430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5695_08435	COG0196	riboflavin kinase activity
C5695_08440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C5695_08445	COG1185	polyribonucleotide nucleotidyltransferase activity
C5695_08450	COG0726	polysaccharide deacetylase
C5695_08455	COG0612	Peptidase, M16
C5695_08465	COG1873	PFAM PRC-barrel domain
C5695_08470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5695_08475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C5695_08480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5695_08485	COG0527	aspartate kinase activity
C5695_08495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C5695_08500	COG0740	serine-type endopeptidase activity
C5695_08510	COG4980	gas vesicle protein
C5695_08510	COG1674	ftsk spoiiie
C5695_08515	COG2188	Transcriptional regulator
C5695_08520	COG2814	Major facilitator Superfamily
C5695_08525	COG2409	Drug exporters of the RND superfamily
C5695_08525	COG1033	growth of symbiont in host cell
C5695_08530	COG0612	Peptidase, M16
C5695_08535	COG0612	Peptidase, M16
C5695_08545	COG1033	growth of symbiont in host cell
C5695_08545	COG2409	Drug exporters of the RND superfamily
C5695_08550	COG0300	oxidoreductase activity
C5695_08565	COG1426	Protein conserved in bacteria
C5695_08570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C5695_08575	COG1546	Belongs to the CinA family
C5695_08575	COG1058	Belongs to the CinA family
C5695_08580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C5695_08590	COG1418	mRNA catabolic process
C5695_08595	COG1692	metallophosphoesterase
C5695_08600	COG2359	stage V sporulation protein S
C5695_08605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C5695_08615	COG1063	alcohol dehydrogenase
C5695_08620	COG0156	8-amino-7-oxononanoate synthase activity
C5695_08630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5695_08635	COG4550	Control of competence regulator ComK, YlbF/YmcA
C5695_08650	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C5695_08655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C5695_08675	COG1329	Transcriptional regulator
C5695_08680	COG4195	phage-related replication protein
C5695_08685	COG0457	Tetratricopeptide repeat
C5695_08695	COG1404	Belongs to the peptidase S8 family
C5695_08700	COG4195	phage-related replication protein
C5695_08705	COG1764	response to oxidative stress
C5695_08710	COG2076	Multidrug Resistance protein
C5695_08735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C5695_08740	COG1923	regulation of RNA biosynthetic process
C5695_08755	COG1780	Probably involved in ribonucleotide reductase function
C5695_08760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5695_08765	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5695_08770	COG4112	unkown
C5695_08775	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5695_08780	COG0464	growth
C5695_08785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C5695_08790	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C5695_08795	COG0789	Transcriptional regulator
C5695_08800	COG0174	glutamine synthetase
C5695_08805	COG1733	regulation of RNA biosynthetic process
C5695_08815	COG0457	Tetratricopeptide repeat
C5695_08820	COG5444	nuclease activity
C5695_08860	COG5646	InterPro IPR014922
C5695_08865	COG0457	Tetratricopeptide repeat
C5695_08875	COG3619	membrane
C5695_08880	COG1793	dna ligase
C5695_08880	COG3285	dna ligase
C5695_08885	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C5695_08890	COG4876	unkown
C5695_08900	COG1959	2 iron, 2 sulfur cluster binding
C5695_08905	COG0702	epimerase
C5695_08935	COG1131	(ABC) transporter
C5695_08945	COG0247	lactate metabolic process
C5695_08950	COG1139	Iron-sulfur cluster binding protein
C5695_08955	COG1556	Lactate utilization protein
C5695_08980	COG1309	transcriptional regulator
C5695_08985	COG2124	cytochrome p450
C5695_08985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5695_08990	COG3591	Belongs to the peptidase S1B family
C5695_08995	COG3209	COG3209 Rhs family protein
C5695_09000	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_09015	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C5695_09020	COG1388	LysM domain
C5695_09025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C5695_09030	COG4224	UPF0291 protein
C5695_09035	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5695_09045	COG3763	UPF0154 protein
C5695_09055	COG0785	Cytochrome C biogenesis protein
C5695_09060	COG4846	Membrane protein involved in cytochrome C biogenesis
C5695_09070	COG0071	Belongs to the small heat shock protein (HSP20) family
C5695_09085	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C5695_09090	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_09110	COG0824	Thioesterase
C5695_09120	COG4841	protein insertion into membrane
C5695_09125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C5695_09130	COG1832	CoA-binding protein
C5695_09135	COG0187	DNA topoisomerase II activity
C5695_09140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5695_09150	COG0738	Major facilitator superfamily
C5695_09155	COG0473	3-isopropylmalate dehydrogenase activity
C5695_09165	COG2323	membrane
C5695_09175	COG0659	secondary active sulfate transmembrane transporter activity
C5695_09185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5695_09190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C5695_09195	COG0640	Transcriptional regulator
C5695_09200	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5695_09205	COG0251	oxidation-reduction process
C5695_09220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C5695_09225	COG2323	membrane
C5695_09245	COG0657	acetylesterase activity
C5695_09260	COG2205	protein histidine kinase activity
C5695_09265	COG0745	RESPONSE REGULATOR receiver
C5695_09275	COG3507	Belongs to the glycosyl hydrolase 43 family
C5695_09280	COG1012	belongs to the aldehyde dehydrogenase family
C5695_09285	COG1486	melibiose metabolic process
C5695_09310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5695_09325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_09340	COG5444	nuclease activity
C5695_09345	COG1846	Transcriptional regulator
C5695_09350	COG2814	Major facilitator Superfamily
C5695_09360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_09360	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_09360	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_09365	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_09365	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_09365	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C5695_09370	COG1105	Belongs to the carbohydrate kinase PfkB family
C5695_09380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5695_09400	COG1012	belongs to the aldehyde dehydrogenase family
C5695_09410	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5695_09415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C5695_09420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5695_09425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5695_09430	COG1024	Enoyl-CoA hydratase
C5695_09435	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5695_09440	COG0511	ligase activity, forming carbon-carbon bonds
C5695_09445	COG0439	Biotin carboxylase
C5695_09450	COG0318	PFAM AMP-dependent synthetase and ligase
C5695_09455	COG1960	acyl-CoA dehydrogenase activity
C5695_09460	COG1649	PFAM Uncharacterised BCR, COG1649
C5695_09470	COG1349	DNA-binding transcription factor activity
C5695_09480	COG3835	regulator
C5695_09485	COG0277	FAD linked oxidase domain protein
C5695_09490	COG0247	lactate metabolic process
C5695_09515	COG0166	Belongs to the GPI family
C5695_09520	COG0586	Pfam SNARE associated Golgi protein
C5695_09525	COG1587	Uroporphyrinogen-III synthase
C5695_09535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5695_09560	COG0534	Mate efflux family protein
C5695_09565	COG2027	D-alanyl-D-alanine carboxypeptidase
C5695_09570	COG4677	pectinesterase activity
C5695_09575	COG2323	membrane
C5695_09585	COG0493	'glutamate synthase
C5695_09590	COG0067	glutamate synthase
C5695_09590	COG0069	glutamate synthase activity
C5695_09590	COG0070	glutamate synthase
C5695_09595	COG0583	DNA-binding transcription factor activity
C5695_09605	COG1132	(ABC) transporter
C5695_09610	COG0789	Transcriptional regulator
C5695_09610	COG4978	Transcriptional regulator
C5695_09615	COG0454	-acetyltransferase
C5695_09620	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C5695_09625	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C5695_09640	COG0243	molybdopterin cofactor binding
C5695_09650	COG1070	Carbohydrate kinase
C5695_09655	COG2115	Belongs to the xylose isomerase family
C5695_09660	COG1940	carbohydrate kinase activity
C5695_09670	COG2211	Major facilitator Superfamily
C5695_09675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5695_09680	COG1994	Peptidase M50
C5695_09700	COG1309	transcriptional regulator
C5695_09705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5695_09710	COG3708	Transcriptional regulator
C5695_09715	COG2378	regulation of single-species biofilm formation
C5695_09725	COG0640	Transcriptional regulator
C5695_09730	COG0531	amino acid
C5695_09735	COG0741	lytic transglycosylase activity
C5695_09740	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C5695_09745	COG2079	MmgE PrpD family protein
C5695_09750	COG0372	Belongs to the citrate synthase family
C5695_09755	COG2322	membrane
C5695_09765	COG3584	3D domain protein
C5695_09765	COG1388	LysM domain
C5695_09770	COG0514	ATP-dependent DNA helicase (RecQ)
C5695_09780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5695_09785	COG0702	epimerase
C5695_09805	COG1012	belongs to the aldehyde dehydrogenase family
C5695_09810	COG1657	PFAM Prenyltransferase squalene oxidase
C5695_09815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5695_09820	COG0385	Bile acid
C5695_09830	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5695_09835	COG0567	Dehydrogenase, E1 component
C5695_09840	COG4548	von Willebrand factor, type A
C5695_09845	COG0714	Associated with various cellular activities
C5695_09850	COG2032	superoxide dismutase activity
C5695_09855	COG0791	NLP P60 protein
C5695_09855	COG1388	LysM domain
C5695_09860	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C5695_09865	COG0534	Mate efflux family protein
C5695_09870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5695_09875	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5695_09885	COG2962	Rard protein
C5695_09900	COG1733	regulation of RNA biosynthetic process
C5695_09905	COG0778	Nitroreductase
C5695_09915	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5695_09920	COG3409	Peptidoglycan-binding domain 1 protein
C5695_09920	COG0793	Belongs to the peptidase S41A family
C5695_09925	COG2226	methyltransferase
C5695_09935	COG1876	peptidase activity
C5695_09940	COG0813	purine-nucleoside phosphorylase activity
C5695_09950	COG0671	phosphoesterase, PA-phosphatase related
C5695_09965	COG4479	Belongs to the UPF0346 family
C5695_09975	COG1509	lysine 2,3-aminomutase activity
C5695_09980	COG3829	transcription factor binding
C5695_09995	COG4641	Protein conserved in bacteria
C5695_10005	COG1086	Polysaccharide biosynthesis protein
C5695_10010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5695_10015	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C5695_10020	COG1846	Transcriptional regulator
C5695_10040	COG4698	Protein conserved in bacteria
C5695_10045	COG2755	lipolytic protein G-D-S-L family
C5695_10050	COG1999	signal sequence binding
C5695_10065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C5695_10070	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C5695_10075	COG1272	protein, Hemolysin III
C5695_10080	COG0204	Acyl-transferase
C5695_10085	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5695_10090	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5695_10095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5695_10105	COG2136	Putative SAM-dependent methyltransferase
C5695_10105	COG2521	methyltransferase
C5695_10115	COG0129	dihydroxy-acid dehydratase activity
C5695_10125	COG1413	lyase activity
C5695_10130	COG1418	mRNA catabolic process
C5695_10135	COG0386	Belongs to the glutathione peroxidase family
C5695_10140	COG2759	Belongs to the formate--tetrahydrofolate ligase family
C5695_10145	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C5695_10150	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C5695_10160	COG1278	Cold shock
C5695_10175	COG0328	RNA-DNA hybrid ribonuclease activity
C5695_10180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C5695_10185	COG0328	RNA-DNA hybrid ribonuclease activity
C5695_10195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5695_10205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C5695_10215	COG1755	Isoprenylcysteine carboxyl methyltransferase
C5695_10220	COG3424	synthase
C5695_10225	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5695_10225	COG0456	acetyltransferase
C5695_10230	COG0726	polysaccharide deacetylase
C5695_10245	COG3331	DNA recombination
C5695_10330	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C5695_10350	COG0756	dUTP diphosphatase activity
C5695_10370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5695_10375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5695_10380	COG1780	Probably involved in ribonucleotide reductase function
C5695_10470	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
C5695_10475	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5695_10490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5695_10495	COG0358	DNA primase activity
C5695_10500	COG0305	Participates in initiation and elongation during chromosome replication
C5695_10510	COG2887	Belongs to the helicase family. UvrD subfamily
C5695_10525	COG0194	GDP metabolic process
C5695_10620	COG4474	Belongs to the UPF0398 family
C5695_10640	COG0328	RNA-DNA hybrid ribonuclease activity
C5695_10645	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5695_10665	COG3655	Transcriptional regulator
C5695_10680	COG0582	viral genome integration into host DNA
C5695_10815	COG0776	regulation of translation
C5695_10840	COG4373	Mu-like prophage FluMu protein gp28
C5695_10940	COG0582	viral genome integration into host DNA
C5695_10945	COG1396	sequence-specific DNA binding
C5695_10990	COG3617	BRO family, N-terminal domain
C5695_11005	COG1196	nuclear chromosome segregation
C5695_11005	COG0741	lytic transglycosylase activity
C5695_11005	COG0739	heme binding
C5695_11010	COG1196	nuclear chromosome segregation
C5695_11010	COG0739	heme binding
C5695_11010	COG0741	lytic transglycosylase activity
C5695_11020	COG2433	Pfam Transposase IS66
C5695_11035	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5695_11060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5695_11085	COG0457	Tetratricopeptide repeat
C5695_11100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5695_11105	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C5695_11110	COG1199	ATP-dependent helicase activity
C5695_11120	COG0116	Belongs to the methyltransferase superfamily
C5695_11130	COG3599	regulation of cell shape
C5695_11135	COG4474	Belongs to the UPF0398 family
C5695_11145	COG3359	exonuclease
C5695_11150	COG1205	dead DEAH box helicase
C5695_11150	COG1111	helicase
C5695_11155	COG1902	pentaerythritol trinitrate reductase activity
C5695_11160	COG2190	(PTS) system
C5695_11165	COG0071	Belongs to the small heat shock protein (HSP20) family
C5695_11195	COG3331	DNA recombination
C5695_11200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5695_11200	COG4499	WXG100 protein secretion system (Wss), protein YukC
C5695_11210	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5695_11215	COG3935	DnaD domain protein
C5695_11220	COG0017	Asparaginyl-tRNA synthetase
C5695_11225	COG5353	protein conserved in bacteria
C5695_11235	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5695_11235	COG1199	ATP-dependent helicase activity
C5695_11240	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C5695_11245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C5695_11250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C5695_11260	COG0617	tRNA 3'-terminal CCA addition
C5695_11265	COG0438	transferase activity, transferring glycosyl groups
C5695_11270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C5695_11275	COG1803	Methylglyoxal synthase
C5695_11280	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C5695_11285	COG1694	Mazg nucleotide pyrophosphohydrolase
C5695_11290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5695_11300	COG4347	Protein of unknown function (DUF1405)
C5695_11305	COG2010	Cytochrome c
C5695_11305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5695_11310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C5695_11315	COG0723	plastoquinol--plastocyanin reductase activity
C5695_11325	COG5582	Belongs to the UPF0302 family
C5695_11330	COG0457	Tetratricopeptide repeat
C5695_11335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C5695_11340	COG0287	Prephenate dehydrogenase
C5695_11345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C5695_11350	COG0159	tryptophan synthase activity
C5695_11355	COG0133	tryptophan synthase activity
C5695_11360	COG0135	phosphoribosylanthranilate isomerase activity
C5695_11365	COG0134	indole-3-glycerol-phosphate synthase activity
C5695_11370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C5695_11380	COG4401	Chorismate mutase type I
C5695_11385	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5695_11390	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C5695_11395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C5695_11400	COG0105	UTP biosynthetic process
C5695_11405	COG0142	geranyltranstransferase activity
C5695_11410	COG2226	methyltransferase
C5695_11415	COG0142	geranyltranstransferase activity
C5695_11425	COG0302	gtp cyclohydrolase
C5695_11430	COG0776	regulation of translation
C5695_11435	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C5695_11450	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C5695_11455	COG1160	GTP binding
C5695_11485	COG1304	FMN binding
C5695_11490	COG0539	negative regulation of cytoplasmic translation
C5695_11495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5695_11505	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C5695_11510	COG2959	enzyme of heme biosynthesis
C5695_11515	COG3773	Cell wall hydrolase
C5695_11515	COG3409	Peptidoglycan-binding domain 1 protein
C5695_11520	COG2339	peptidase activity
C5695_11525	COG0492	ferredoxin-NADP+ reductase activity
C5695_11530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5695_11535	COG4862	establishment of competence for transformation
C5695_11540	COG1408	metallophosphoesterase
C5695_11550	COG1388	LysM domain
C5695_11555	COG1266	CAAX protease self-immunity
C5695_11560	COG0514	ATP-dependent DNA helicase (RecQ)
C5695_11565	COG4955	Helix-turn-helix domain
C5695_11570	COG1141	Ferredoxin
C5695_11575	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C5695_11580	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C5695_11585	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5695_11585	COG3409	Peptidoglycan-binding domain 1 protein
C5695_11595	COG1595	DNA-templated transcription, initiation
C5695_11600	COG5002	protein histidine kinase activity
C5695_11605	COG0745	RESPONSE REGULATOR receiver
C5695_11610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5695_11615	COG1333	cytochrome c biogenesis protein
C5695_11620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_11625	COG1187	pseudouridine synthase activity
C5695_11630	COG0700	Nucleoside recognition
C5695_11635	COG2715	membrane protein required for spore maturation
C5695_11640	COG1686	Belongs to the peptidase S11 family
C5695_11650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C5695_11655	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C5695_11665	COG1547	Domain of unknown function (DUF309)
C5695_11670	COG0456	acetyltransferase
C5695_11675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C5695_11680	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5695_11680	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5695_11685	COG0307	riboflavin synthase, alpha
C5695_11710	COG2814	Major facilitator Superfamily
C5695_11715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C5695_11720	COG4086	secreted protein
C5695_11725	COG0019	diaminopimelate decarboxylase activity
C5695_11730	COG0697	spore germination
C5695_11745	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C5695_11765	COG1191	sigma factor activity
C5695_11770	COG2172	sigma factor antagonist activity
C5695_11780	COG1686	Belongs to the peptidase S11 family
C5695_11785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C5695_11790	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C5695_11795	COG4974	Belongs to the 'phage' integrase family
C5695_11805	COG0735	belongs to the Fur family
C5695_11810	COG1300	Membrane
C5695_11815	COG1404	Belongs to the peptidase S8 family
C5695_11825	COG2153	protein acetylation
C5695_11830	COG1379	DNA repair
C5695_11835	COG0494	nUDIX hydrolase
C5695_11840	COG0667	Aldo Keto reductase
C5695_11855	COG1073	alpha beta
C5695_11860	COG0457	Tetratricopeptide repeat
C5695_11870	COG4918	Iron-sulphur cluster biosynthesis
C5695_11875	COG4305	rare lipoprotein A
C5695_11880	COG0456	acetyltransferase
C5695_11880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C5695_11885	COG0456	acetyltransferase
C5695_11895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5695_11905	COG2211	Major facilitator Superfamily
C5695_11915	COG1072	(Pantothenic acid kinase))
C5695_11920	COG0446	pyridine nucleotide-disulphide oxidoreductase
C5695_11925	COG0300	oxidoreductase activity
C5695_11930	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5695_11935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5695_11950	COG4187	Peptidase family M20/M25/M40
C5695_11955	COG1902	pentaerythritol trinitrate reductase activity
C5695_11960	COG0596	Alpha beta hydrolase
C5695_11965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C5695_11975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5695_11980	COG2188	Transcriptional regulator
C5695_11985	COG2723	6-phospho-beta-galactosidase activity
C5695_11990	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5695_11995	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5695_12000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5695_12005	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_12010	COG4975	Glucose uptake
C5695_12015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5695_12020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C5695_12030	COG0706	membrane insertase activity
C5695_12040	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5695_12045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C5695_12050	COG0346	lactoylglutathione lyase activity
C5695_12055	COG1376	ErfK ybiS ycfS ynhG family protein
C5695_12060	COG4129	membrane
C5695_12065	COG1126	abc transporter atp-binding protein
C5695_12070	COG0765	amino acid transport
C5695_12075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_12085	COG1597	lipid kinase activity
C5695_12095	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5695_12100	COG0022	dehydrogenase e1 component
C5695_12105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C5695_12110	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5695_12115	COG3426	butyrate kinase activity
C5695_12120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5695_12125	COG0280	phosphate acetyltransferase
C5695_12130	COG3829	transcription factor binding
C5695_12130	COG3290	protein histidine kinase activity
C5695_12140	COG0584	glycerophosphoryl diester phosphodiesterase
C5695_12145	COG0457	Tetratricopeptide repeat
C5695_12155	COG0745	RESPONSE REGULATOR receiver
C5695_12160	COG0750	zinc metalloprotease
C5695_12165	COG0497	DNA recombination
C5695_12170	COG1438	arginine binding
C5695_12175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C5695_12180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C5695_12185	COG0142	geranyltranstransferase activity
C5695_12190	COG1722	exodeoxyribonuclease VII activity
C5695_12195	COG1570	exodeoxyribonuclease VII activity
C5695_12200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5695_12205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C5695_12210	COG1302	Protein conserved in bacteria
C5695_12215	COG0439	Biotin carboxylase
C5695_12220	COG0511	ligase activity, forming carbon-carbon bonds
C5695_12260	COG3854	ATPases associated with a variety of cellular activities
C5695_12270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5695_12275	COG0006	proline dipeptidase activity
C5695_12280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C5695_12290	COG3872	metal-dependent enzyme
C5695_12300	COG1752	Esterase of the alpha-beta hydrolase superfamily
C5695_12305	COG1321	iron dependent repressor
C5695_12310	COG0095	Lipoate-protein ligase
C5695_12315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5695_12320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5695_12325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C5695_12330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C5695_12335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5695_12360	COG0681	Belongs to the peptidase S26 family
C5695_12395	COG4970	Tfp pilus assembly protein FimT
C5695_12400	COG4537	Required for transformation and DNA binding
C5695_12405	COG1459	type II secretion system
C5695_12410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C5695_12415	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_12425	COG1393	Belongs to the ArsC family
C5695_12435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5695_12445	COG0011	TIGRFAM Protein of
C5695_12450	COG2814	Major facilitator Superfamily
C5695_12455	COG2866	Carboxypeptidase
C5695_12460	COG1368	sulfuric ester hydrolase activity
C5695_12465	COG1940	carbohydrate kinase activity
C5695_12470	COG4483	Protein conserved in bacteria
C5695_12475	COG0705	Rhomboid family
C5695_12475	COG0457	Tetratricopeptide repeat
C5695_12485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C5695_12490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5695_12500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5695_12505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5695_12510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C5695_12515	COG0581	inorganic phosphate transmembrane transporter activity
C5695_12520	COG0573	inorganic phosphate transmembrane transporter activity
C5695_12525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C5695_12535	COG0477	Major facilitator Superfamily
C5695_12540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5695_12545	COG2839	Protein conserved in bacteria
C5695_12550	COG5521	maltodextrose utilization protein MalA
C5695_12555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C5695_12560	COG1388	LysM domain
C5695_12565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5695_12570	COG4709	membrane
C5695_12575	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C5695_12580	COG1940	carbohydrate kinase activity
C5695_12585	COG0735	belongs to the Fur family
C5695_12590	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5695_12595	COG1121	(ABC) transporter
C5695_12600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5695_12615	COG0513	Belongs to the DEAD box helicase family
C5695_12625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C5695_12630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5695_12635	COG2384	SAM-dependent methyltransferase
C5695_12640	COG2010	Cytochrome c
C5695_12645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5695_12650	COG0358	DNA primase activity
C5695_12655	COG1671	Belongs to the UPF0178 family
C5695_12660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C5695_12665	COG0517	IMP dehydrogenase activity
C5695_12670	COG0751	glycine-tRNA ligase activity
C5695_12675	COG0752	glycyl-tRNA synthetase alpha subunit
C5695_12680	COG1381	Involved in DNA repair and RecF pathway recombination
C5695_12690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C5695_12695	COG0295	cytidine deaminase activity
C5695_12700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C5695_12705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C5695_12710	COG1480	7TM receptor with intracellular HD hydrolase
C5695_12715	COG1702	phosphate starvation-inducible protein PhoH
C5695_12720	COG0561	phosphatase activity
C5695_12735	COG4864	UPF0365 protein
C5695_12740	COG1030	water channel activity
C5695_12745	COG1610	YqeY-like protein
C5695_12750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C5695_12755	COG1283	sodium-dependent phosphate transmembrane transporter activity
C5695_12760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5695_12765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5695_12770	COG2264	protein methyltransferase activity
C5695_12775	COG0484	heat shock protein binding
C5695_12780	COG0443	Heat shock 70 kDa protein
C5695_12785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5695_12790	COG1420	regulation of RNA biosynthetic process
C5695_12795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5695_12800	COG0481	GTPase activity
C5695_12810	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5695_12815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C5695_12820	COG0268	Binds directly to 16S ribosomal RNA
C5695_12825	COG1466	dna polymerase III delta subunit
C5695_12835	COG0658	competence protein
C5695_12835	COG2333	competence protein COMEC
C5695_12840	COG2131	deaminase
C5695_12845	COG1555	photosystem II stabilization
C5695_12850	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C5695_12855	COG2226	methyltransferase
C5695_12860	COG0799	negative regulation of ribosome biogenesis
C5695_12865	COG1713	HD superfamily hydrolase involved in NAD metabolism
C5695_12870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C5695_12875	COG1534	Rna-binding protein
C5695_12880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5695_12885	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C5695_12890	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C5695_12900	COG2755	lipolytic protein G-D-S-L family
C5695_12905	COG0726	polysaccharide deacetylase
C5695_12910	COG0457	Tetratricopeptide repeat
C5695_12950	COG0726	polysaccharide deacetylase
C5695_12980	COG2160	L-arabinose isomerase activity
C5695_12995	COG1609	Transcriptional regulator
C5695_13005	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C5695_13010	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C5695_13015	COG1733	regulation of RNA biosynthetic process
C5695_13050	COG2602	Beta-lactamase
C5695_13055	COG1960	acyl-CoA dehydrogenase activity
C5695_13060	COG3546	catalase activity
C5695_13065	COG1063	alcohol dehydrogenase
C5695_13075	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_13085	COG1115	amino acid carrier protein
C5695_13090	COG0583	DNA-binding transcription factor activity
C5695_13095	COG0842	Transport permease protein
C5695_13100	COG1511	domain protein
C5695_13100	COG0842	Transport permease protein
C5695_13105	COG1131	(ABC) transporter
C5695_13115	COG1063	alcohol dehydrogenase
C5695_13125	COG2226	methyltransferase
C5695_13145	COG0626	cystathionine gamma-synthase activity
C5695_13150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5695_13155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C5695_13160	COG2226	methyltransferase
C5695_13180	COG0768	penicillin binding
C5695_13185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C5695_13190	COG0572	uridine kinase
C5695_13210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C5695_13215	COG0183	Belongs to the thiolase family
C5695_13220	COG0318	PFAM AMP-dependent synthetase and ligase
C5695_13225	COG1268	BioY protein
C5695_13230	COG3906	Belongs to the UPF0473 family
C5695_13235	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C5695_13240	COG4472	Bacterial protein of unknown function (DUF965)
C5695_13245	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5695_13250	COG0628	permease
C5695_13255	COG1126	abc transporter atp-binding protein
C5695_13260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_13270	COG0765	amino acid transport
C5695_13285	COG3881	PFAM PRC-barrel domain
C5695_13290	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5695_13295	COG0457	Tetratricopeptide repeat
C5695_13300	COG0482	sulfurtransferase activity
C5695_13305	COG1104	cysteine desulfurase activity
C5695_13310	COG1959	2 iron, 2 sulfur cluster binding
C5695_13315	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C5695_13325	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C5695_13340	COG0124	histidyl-tRNA synthetase
C5695_13345	COG4991	sh3 domain protein
C5695_13345	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5695_13345	COG3103	Sh3 type 3 domain protein
C5695_13350	COG1490	D-aminoacyl-tRNA deacylase activity
C5695_13355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C5695_13360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C5695_13365	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C5695_13365	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C5695_13370	COG5416	Lipopolysaccharide assembly protein A domain
C5695_13375	COG0490	domain, Protein
C5695_13380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5695_13380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C5695_13390	COG2244	polysaccharide biosynthetic process
C5695_13395	COG2323	membrane
C5695_13405	COG1862	Preprotein translocase
C5695_13410	COG0343	queuine tRNA-ribosyltransferase activity
C5695_13415	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C5695_13425	COG2255	four-way junction helicase activity
C5695_13430	COG0632	four-way junction helicase activity
C5695_13440	COG2112	serine threonine protein kinase
C5695_13450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C5695_13465	COG1388	LysM domain
C5695_13470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C5695_13475	COG0157	Belongs to the NadC ModD family
C5695_13480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C5695_13485	COG1104	cysteine desulfurase activity
C5695_13490	COG1827	regulation of RNA biosynthetic process
C5695_13500	COG0077	Prephenate dehydratase
C5695_13505	COG4492	Belongs to the UPF0735 family
C5695_13510	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C5695_13515	COG3290	protein histidine kinase activity
C5695_13520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C5695_13525	COG2868	ribosomal protein
C5695_13530	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C5695_13535	COG1994	Peptidase M50
C5695_13540	COG0739	heme binding
C5695_13545	COG2894	cell division
C5695_13550	COG0850	regulation of cytokinetic process
C5695_13555	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C5695_13560	COG1792	Involved in formation and maintenance of cell shape
C5695_13565	COG1077	Cell shape determining protein MreB Mrl
C5695_13570	COG2003	Belongs to the UPF0758 family
C5695_13575	COG0424	maF-like protein
C5695_13595	COG2124	cytochrome p450
C5695_13620	COG0285	dihydrofolate synthase activity
C5695_13625	COG0525	valine-tRNA ligase activity
C5695_13635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5695_13640	COG1388	LysM domain
C5695_13645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C5695_13650	COG0113	porphobilinogen synthase activity
C5695_13655	COG1587	Uroporphyrinogen-III synthase
C5695_13660	COG0181	hydroxymethylbilane synthase activity
C5695_13665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C5695_13670	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C5695_13680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C5695_13685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5695_13690	COG1067	ATP-dependent peptidase activity
C5695_13690	COG0470	DNA polymerase III
C5695_13695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C5695_13700	COG0544	peptidyl-prolyl cis-trans isomerase activity
C5695_13705	COG1477	protein flavinylation
C5695_13705	COG0457	Tetratricopeptide repeat
C5695_13710	COG0066	3-isopropylmalate dehydratase activity
C5695_13715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C5695_13720	COG0473	3-isopropylmalate dehydrogenase activity
C5695_13725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C5695_13730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C5695_13735	COG0440	acetolactate synthase activity
C5695_13740	COG0028	Belongs to the TPP enzyme family
C5695_13745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5695_13750	COG2706	6-phosphogluconolactonase activity
C5695_13760	COG3339	Conserved Protein
C5695_13765	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C5695_13770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C5695_13775	COG1696	Membrane protein involved in D-alanine export
C5695_13840	COG0622	Phosphoesterase
C5695_13845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C5695_13850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C5695_13855	COG5401	PFAM Sporulation and spore germination
C5695_13860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C5695_13865	COG1846	Transcriptional regulator
C5695_13900	COG3409	Peptidoglycan-binding domain 1 protein
C5695_13900	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5695_13990	COG0740	serine-type endopeptidase activity
C5695_14035	COG0582	viral genome integration into host DNA
C5695_14040	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
C5695_14140	COG2197	response regulator
C5695_14145	COG2851	Citrate transporter
C5695_14150	COG0583	DNA-binding transcription factor activity
C5695_14155	COG2828	Protein conserved in bacteria
C5695_14165	COG0824	Thioesterase
C5695_14170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C5695_14175	COG1053	succinate dehydrogenase
C5695_14180	COG2009	succinate dehydrogenase
C5695_14185	COG1719	4-vinyl reductase, 4VR
C5695_14190	COG0527	aspartate kinase activity
C5695_14195	COG0322	excinuclease ABC activity
C5695_14200	COG3118	belongs to the thioredoxin family
C5695_14205	COG3534	alpha-L-arabinofuranosidase
C5695_14210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C5695_14215	COG2086	electron transfer activity
C5695_14220	COG1024	Enoyl-CoA hydratase
C5695_14225	COG1309	transcriptional regulator
C5695_14230	COG0318	PFAM AMP-dependent synthetase and ligase
C5695_14240	COG3766	membrane
C5695_14245	COG1193	negative regulation of DNA recombination
C5695_14250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5695_14250	COG1796	DNA polymerase
C5695_14255	COG1286	toxin biosynthetic process
C5695_14260	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C5695_14265	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C5695_14270	COG0072	phenylalanine-tRNA ligase activity
C5695_14270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5695_14275	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5695_14280	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C5695_14290	COG1966	Carbon starvation protein
C5695_14295	COG1363	Peptidase, m42
C5695_14305	COG3326	Membrane
C5695_14310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C5695_14315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C5695_14320	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C5695_14325	COG1346	cytolysis
C5695_14335	COG3279	Response regulator of the LytR AlgR family
C5695_14340	COG3275	phosphorelay sensor kinase activity
C5695_14355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C5695_14365	COG0398	Pfam SNARE associated Golgi protein
C5695_14370	COG1484	DNA-dependent DNA replication
C5695_14375	COG3611	Membrane attachment protein
C5695_14380	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C5695_14390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C5695_14395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5695_14400	COG0237	dephospho-CoA kinase activity
C5695_14405	COG1971	Probably functions as a manganese efflux pump
C5695_14410	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C5695_14415	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5695_14415	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5695_14420	COG5002	protein histidine kinase activity
C5695_14425	COG0745	RESPONSE REGULATOR receiver
C5695_14430	COG0039	L-malate dehydrogenase activity
C5695_14435	COG0538	isocitrate dehydrogenase activity
C5695_14440	COG0372	Belongs to the citrate synthase family
C5695_14445	COG2707	UPF0756 membrane protein
C5695_14450	COG0628	permease
C5695_14455	COG3030	protein affecting phage T7 exclusion by the F plasmid
C5695_14465	COG0205	6-phosphofructokinase activity
C5695_14470	COG0825	malonyl-CoA metabolic process
C5695_14475	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C5695_14480	COG0281	malic enzyme
C5695_14485	COG0587	DNA-directed DNA polymerase activity
C5695_14505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C5695_14515	COG4109	DRTGG domain
C5695_14520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C5695_14525	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_14535	COG0165	Argininosuccinate lyase
C5695_14540	COG0137	argininosuccinate synthase activity
C5695_14545	COG0521	Mo-molybdopterin cofactor biosynthetic process
C5695_14550	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5695_14555	COG0827	DNA restriction-modification system
C5695_14560	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C5695_14565	COG3874	Sporulation protein YtfJ
C5695_14575	COG1714	RDD family
C5695_14580	COG0616	signal peptide processing
C5695_14585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C5695_14595	COG3239	Fatty acid desaturase
C5695_14600	COG4585	Histidine kinase
C5695_14605	COG2197	response regulator
C5695_14610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_14615	COG0745	RESPONSE REGULATOR receiver
C5695_14620	COG0642	Histidine kinase
C5695_14625	COG1136	(ABC) transporter
C5695_14630	COG0577	efflux transmembrane transporter activity
C5695_14635	COG0402	S-adenosylhomocysteine deaminase activity
C5695_14640	COG2249	NAD(P)H dehydrogenase (quinone) activity
C5695_14650	COG1279	arginine transmembrane transporter activity
C5695_14655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5695_14665	COG0301	tRNA thio-modification
C5695_14670	COG1104	cysteine desulfurase activity
C5695_14675	COG1114	Component of the transport system for branched-chain amino acids
C5695_14680	COG1114	Component of the transport system for branched-chain amino acids
C5695_14685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C5695_14690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C5695_14695	COG1309	transcriptional regulator
C5695_14700	COG1956	GAF domain-containing protein
C5695_14705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C5695_14715	COG1335	isochorismatase
C5695_14725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C5695_14730	COG2329	Antibiotic biosynthesis monooxygenase
C5695_14735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C5695_14740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C5695_14745	COG0454	-acetyltransferase
C5695_14750	COG0517	IMP dehydrogenase activity
C5695_14755	COG0123	including yeast histone deacetylase and acetoin utilization protein
C5695_14760	COG1609	Transcriptional regulator
C5695_14765	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C5695_14765	COG1605	Chorismate mutase
C5695_14770	COG3118	belongs to the thioredoxin family
C5695_14775	COG4980	gas vesicle protein
C5695_14780	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C5695_14785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C5695_14790	COG1674	ftsk spoiiie
C5695_14795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5695_14800	COG4848	Belongs to the UPF0354 family
C5695_14805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_14820	COG1363	Peptidase, m42
C5695_14825	COG5584	Small secreted protein
C5695_14830	COG0281	malic enzyme
C5695_14835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C5695_14840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C5695_14850	COG0510	thiamine kinase activity
C5695_14860	COG1597	lipid kinase activity
C5695_14870	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C5695_14875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5695_14880	COG3340	Belongs to the peptidase S51 family
C5695_14885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C5695_14890	COG2252	PERMEase
C5695_14895	COG1349	DNA-binding transcription factor activity
C5695_14900	COG1187	pseudouridine synthase activity
C5695_14905	COG2244	polysaccharide biosynthetic process
C5695_14910	COG2081	HI0933 family
C5695_14920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C5695_14925	COG3196	Protein conserved in bacteria
C5695_14935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5695_14940	COG5578	integral membrane protein
C5695_14945	COG0673	inositol 2-dehydrogenase activity
C5695_14950	COG1653	transport
C5695_14955	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C5695_14960	COG4209	transmembrane transport
C5695_14965	COG2207	Transcriptional regulator
C5695_14980	COG1653	transport
C5695_14985	COG0395	ABC-type sugar transport system, permease component
C5695_14990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5695_14995	COG1073	alpha beta
C5695_15000	COG0495	leucyl-tRNA aminoacylation
C5695_15010	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_15010	COG2202	Pas domain
C5695_15015	COG2433	Pfam Transposase IS66
C5695_15020	COG0577	efflux transmembrane transporter activity
C5695_15025	COG1136	(ABC) transporter
C5695_15035	COG1131	(ABC) transporter
C5695_15040	COG1725	Transcriptional regulator
C5695_15055	COG1242	4 iron, 4 sulfur cluster binding
C5695_15060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C5695_15070	COG2267	carboxylic ester hydrolase activity
C5695_15075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C5695_15080	COG0367	asparagine synthase
C5695_15085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C5695_15090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C5695_15100	COG1506	peptidase
C5695_15105	COG1233	COG1233 Phytoene dehydrogenase and related
C5695_15125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C5695_15130	COG1116	anion transmembrane transporter activity
C5695_15135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C5695_15145	COG0494	nUDIX hydrolase
C5695_15150	COG2310	stress, protein
C5695_15165	COG4824	toxin secretion phage lysis holin
C5695_15175	COG0783	Belongs to the Dps family
C5695_15190	COG1854	S-ribosylhomocysteine lyase activity
C5695_15195	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C5695_15200	COG0288	reversible hydration of carbon dioxide
C5695_15205	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5695_15205	COG3443	Belongs to the bacterial solute-binding protein 9 family
C5695_15210	COG0254	rRNA binding
C5695_15220	COG1271	oxidase subunit
C5695_15225	COG1294	oxidase, subunit
C5695_15240	COG4948	Mandelate Racemase Muconate Lactonizing
C5695_15245	COG0318	PFAM AMP-dependent synthetase and ligase
C5695_15250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C5695_15255	COG0596	Alpha beta hydrolase
C5695_15260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C5695_15265	COG1169	isochorismate synthase
C5695_15270	COG1575	Belongs to the MenA family. Type 1 subfamily
C5695_15275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5695_15405	COG3859	Proton-coupled thiamine transporter YuaJ
C5695_15415	COG1247	-acetyltransferase
C5695_15420	COG2268	Band 7 protein
C5695_15425	COG1585	Membrane protein implicated in regulation of membrane protease activity
C5695_15430	COG2318	DinB family
C5695_15435	COG1454	alcohol dehydrogenase
C5695_15445	COG1510	regulation of RNA biosynthetic process
C5695_15460	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5695_15460	COG3409	Peptidoglycan-binding domain 1 protein
C5695_15510	COG3778	Protein conserved in bacteria
C5695_15515	COG3299	homolog of phage Mu protein gp47
C5695_15520	COG3628	GPW Gp25 family protein
C5695_15530	COG4193	domain, Protein
C5695_15535	COG1652	LysM domain
C5695_15540	COG3953	SLT domain
C5695_15540	COG5280	Phage tail tape measure protein TP901
C5695_15540	COG5280	Phage tail tape measure protein TP901
C5695_15540	COG3953	SLT domain
C5695_15590	COG4653	Phage capsid family
C5695_15595	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C5695_15600	COG5518	Phage portal protein
C5695_15605	COG1783	phage Terminase large subunit
C5695_15610	COG5484	DNA packaging
C5695_15615	COG1595	DNA-templated transcription, initiation
C5695_15640	COG1396	sequence-specific DNA binding
C5695_15650	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C5695_15660	COG1968	undecaprenyl-diphosphatase activity
C5695_15665	COG0628	permease
C5695_15675	COG0673	inositol 2-dehydrogenase activity
C5695_15680	COG0693	protein deglycase activity
C5695_15685	COG0840	transmembrane signaling receptor activity
C5695_15690	COG0840	transmembrane signaling receptor activity
C5695_15695	COG0840	transmembrane signaling receptor activity
C5695_15700	COG0840	transmembrane signaling receptor activity
C5695_15715	COG2070	2-Nitropropane dioxygenase
C5695_15720	COG1253	flavin adenine dinucleotide binding
C5695_15725	COG2738	Putative neutral zinc metallopeptidase
C5695_15735	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C5695_15750	COG0166	Belongs to the GPI family
C5695_15755	COG1979	alcohol dehydrogenase
C5695_15760	COG1979	alcohol dehydrogenase
C5695_15765	COG2155	Conserved Protein
C5695_15770	COG1098	S1 RNA binding domain
C5695_15775	COG0436	Aminotransferase
C5695_15780	COG1522	sequence-specific DNA binding
C5695_15785	COG2267	carboxylic ester hydrolase activity
C5695_15795	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C5695_15800	COG2205	protein histidine kinase activity
C5695_15815	COG5018	Exonuclease
C5695_15820	COG2814	Major facilitator Superfamily
C5695_15825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5695_15830	COG3011	Protein conserved in bacteria
C5695_15840	COG3290	protein histidine kinase activity
C5695_15845	COG4565	transcriptional regulatory protein
C5695_15870	COG3493	citrate carrier protein
C5695_15880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5695_15880	COG2111	Na H antiporter
C5695_15885	COG2111	Na H antiporter
C5695_15890	COG1006	Multisubunit Na H antiporter MnhC subunit
C5695_15895	COG0651	ATP synthesis coupled electron transport
C5695_15900	COG1863	multisubunit Na H antiporter MnhE subunit
C5695_15905	COG2212	antiporter activity
C5695_15910	COG1320	monovalent cation:proton antiporter activity
C5695_15915	COG2050	protein possibly involved in aromatic compounds catabolism
C5695_15920	COG2197	response regulator
C5695_15925	COG4585	Histidine kinase
C5695_15935	COG0142	geranyltranstransferase activity
C5695_15950	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C5695_15955	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C5695_15960	COG1335	isochorismatase
C5695_15965	COG5506	Protein of unknown function (DUF1694)
C5695_15985	COG0628	permease
C5695_16000	COG1418	mRNA catabolic process
C5695_16005	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_16015	COG1511	domain protein
C5695_16020	COG1674	ftsk spoiiie
C5695_16020	COG0433	COG0433 Predicted ATPase
C5695_16025	COG4499	WXG100 protein secretion system (Wss), protein YukC
C5695_16030	COG5417	Belongs to the EsaB family
C5695_16035	COG4842	Belongs to the WXG100 family
C5695_16040	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C5695_16040	COG2508	Transcriptional regulator
C5695_16045	COG0686	Belongs to the AlaDH PNT family
C5695_16050	COG1268	BioY protein
C5695_16055	COG4326	sporulation control protein
C5695_16060	COG2056	Na+-H+ antiporter family
C5695_16070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C5695_16075	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C5695_16080	COG3584	3D domain protein
C5695_16090	COG1252	NADH dehydrogenase
C5695_16095	COG0492	ferredoxin-NADP+ reductase activity
C5695_16110	COG0789	Transcriptional regulator
C5695_16115	COG5504	Zn-dependent protease
C5695_16120	COG0316	Belongs to the HesB IscA family
C5695_16125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C5695_16130	COG4844	belongs to the
C5695_16135	COG1252	NADH dehydrogenase
C5695_16145	COG4837	Protein of unknown function (DUF1462)
C5695_16150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C5695_16155	COG4946	Tricorn protease homolog
C5695_16155	COG1506	peptidase
C5695_16155	COG0823	Involved in the tonB-independent uptake of proteins
C5695_16160	COG0083	homoserine kinase activity
C5695_16165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5695_16170	COG0460	homoserine dehydrogenase
C5695_16175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5695_16180	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C5695_16185	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C5695_16190	COG0647	UMP catabolic process
C5695_16195	COG2445	Protein of unknown function DUF86
C5695_16200	COG4470	Protein conserved in bacteria
C5695_16210	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C5695_16215	COG0739	heme binding
C5695_16230	COG3377	Domain of unknown function (DUF1805)
C5695_16235	COG0737	Belongs to the 5'-nucleotidase family
C5695_16240	COG1801	Protein of unknown function DUF72
C5695_16245	COG2508	Transcriptional regulator
C5695_16255	COG2814	Major facilitator Superfamily
C5695_16265	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C5695_16270	COG2356	endonuclease I
C5695_16280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_16285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_16290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_16295	COG0662	Cupin 2, conserved barrel domain protein
C5695_16300	COG3223	Belongs to the PsiE family
C5695_16305	COG0642	Histidine kinase
C5695_16305	COG5002	protein histidine kinase activity
C5695_16310	COG0745	RESPONSE REGULATOR receiver
C5695_16315	COG2311	Membrane
C5695_16325	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C5695_16345	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C5695_16350	COG0719	Fe-S assembly protein
C5695_16355	COG0822	iron-sulfur transferase activity
C5695_16360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C5695_16365	COG0719	Fe-S assembly protein
C5695_16370	COG0396	ATPase activity
C5695_16375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C5695_16380	COG1464	Belongs to the NlpA lipoprotein family
C5695_16385	COG2011	ABC-type metal ion transport system permease component
C5695_16390	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C5695_16400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_16405	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C5695_16415	COG0509	glycine decarboxylation via glycine cleavage system
C5695_16420	COG1393	Belongs to the ArsC family
C5695_16425	COG1960	acyl-CoA dehydrogenase activity
C5695_16430	COG0183	Belongs to the thiolase family
C5695_16435	COG1024	Enoyl-CoA hydratase
C5695_16435	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5695_16450	COG5577	PFAM Coat F domain
C5695_16460	COG1120	ATPase activity
C5695_16470	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_16475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5695_16480	COG0745	RESPONSE REGULATOR receiver
C5695_16485	COG2770	Histidine kinase
C5695_16485	COG2205	protein histidine kinase activity
C5695_16490	COG1309	transcriptional regulator
C5695_16495	COG0114	fumarate hydratase activity
C5695_16505	COG0697	spore germination
C5695_16510	COG0814	amino acid
C5695_16525	COG2197	response regulator
C5695_16530	COG4585	Histidine kinase
C5695_16535	COG4758	membrane
C5695_16545	COG1842	Phage shock protein A
C5695_16550	COG4758	membrane
C5695_16560	COG2096	Adenosyltransferase
C5695_16565	COG1120	ATPase activity
C5695_16570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_16575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_16585	COG2721	sulfolactate sulfo-lyase activity
C5695_16590	COG0246	Mannitol dehydrogenase
C5695_16595	COG1609	Transcriptional regulator
C5695_16600	COG1904	glucuronate isomerase
C5695_16605	COG2205	protein histidine kinase activity
C5695_16610	COG0745	RESPONSE REGULATOR receiver
C5695_16615	COG1120	ATPase activity
C5695_16620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_16625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_16630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_16635	COG0531	amino acid
C5695_16655	COG1988	membrane-bound metal-dependent
C5695_16660	COG1368	sulfuric ester hydrolase activity
C5695_16665	COG0725	ABC transporter, periplasmic molybdate-binding protein
C5695_16670	COG4149	molybdate abc transporter
C5695_16675	COG0656	L-ascorbic acid biosynthetic process
C5695_16680	COG1940	carbohydrate kinase activity
C5695_16685	COG0025	NhaP-type Na H and K H
C5695_16690	COG2860	membrane
C5695_16695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C5695_16700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5695_16705	COG2217	Heavy metal translocating P-type atpase
C5695_16710	COG1121	(ABC) transporter
C5695_16715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5695_16720	COG0803	Belongs to the bacterial solute-binding protein 9 family
C5695_16730	COG3226	Transcriptional regulator
C5695_16735	COG0784	Response regulator, receiver
C5695_16740	COG4191	Histidine kinase
C5695_16745	COG1027	Aspartate ammonia-lyase
C5695_16755	COG2217	Heavy metal translocating P-type atpase
C5695_16760	COG2608	mercury ion transmembrane transporter activity
C5695_16765	COG1937	Protein conserved in bacteria
C5695_16775	COG0745	RESPONSE REGULATOR receiver
C5695_16775	COG3706	GGDEF domain
C5695_16800	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5695_16820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C5695_16825	COG0557	exoribonuclease II activity
C5695_16830	COG1647	Serine aminopeptidase, S33
C5695_16835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5695_16840	COG2002	toxin-antitoxin pair type II binding
C5695_16845	COG1476	TRANSCRIPTIONal
C5695_16850	COG1396	sequence-specific DNA binding
C5695_16855	COG1396	sequence-specific DNA binding
C5695_16860	COG1733	regulation of RNA biosynthetic process
C5695_16865	COG1174	glycine betaine transport
C5695_16870	COG1732	Glycine betaine
C5695_16875	COG1174	glycine betaine transport
C5695_16880	COG1125	glycine betaine transport
C5695_16880	COG0517	IMP dehydrogenase activity
C5695_16885	COG1510	regulation of RNA biosynthetic process
C5695_16890	COG2095	MarC family integral membrane protein
C5695_16900	COG0456	acetyltransferase
C5695_16920	COG1131	(ABC) transporter
C5695_16930	COG0148	phosphopyruvate hydratase activity
C5695_16935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C5695_16940	COG0149	triose-phosphate isomerase activity
C5695_16945	COG0126	phosphoglycerate kinase activity
C5695_16950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5695_16955	COG2390	Transcriptional regulator
C5695_16960	COG0833	amino acid
C5695_16965	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5695_16970	COG3829	transcription factor binding
C5695_16975	COG2186	Transcriptional regulator
C5695_16980	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C5695_16990	COG0534	Mate efflux family protein
C5695_16995	COG4608	Belongs to the ABC transporter superfamily
C5695_17000	COG0444	Belongs to the ABC transporter superfamily
C5695_17005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C5695_17010	COG0601	transmembrane transport
C5695_17015	COG0747	negative chemotaxis
C5695_17020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5695_17025	COG0110	maltose O-acetyltransferase activity
C5695_17030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C5695_17035	COG2244	polysaccharide biosynthetic process
C5695_17040	COG5039	Polysaccharide pyruvyl transferase
C5695_17045	COG1216	Glycosyl transferase, family 2
C5695_17055	COG0438	transferase activity, transferring glycosyl groups
C5695_17060	COG1215	transferase activity, transferring glycosyl groups
C5695_17065	COG0438	transferase activity, transferring glycosyl groups
C5695_17070	COG1086	Polysaccharide biosynthesis protein
C5695_17075	COG0489	protein tyrosine kinase activity
C5695_17080	COG3944	biosynthesis protein
C5695_17085	COG1396	sequence-specific DNA binding
C5695_17095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_17100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_17105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C5695_17110	COG0726	polysaccharide deacetylase
C5695_17120	COG1124	(ABC) transporter
C5695_17135	COG0601	transmembrane transport
C5695_17140	COG0747	negative chemotaxis
C5695_17145	COG1819	glycosyl
C5695_17160	COG0740	serine-type endopeptidase activity
C5695_17165	COG1611	Belongs to the LOG family
C5695_17170	COG1694	Mazg nucleotide pyrophosphohydrolase
C5695_17175	COG0659	secondary active sulfate transmembrane transporter activity
C5695_17180	COG0288	reversible hydration of carbon dioxide
C5695_17185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C5695_17195	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C5695_17200	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_17205	COG1481	regulation of sporulation
C5695_17210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C5695_17215	COG1660	Displays ATPase and GTPase activities
C5695_17220	COG1051	belongs to the nudix hydrolase family
C5695_17225	COG0492	ferredoxin-NADP+ reductase activity
C5695_17230	COG3883	PFAM NLP P60 protein
C5695_17230	COG0791	NLP P60 protein
C5695_17235	COG0457	Tetratricopeptide repeat
C5695_17240	COG0140	phosphoribosyl-ATP diphosphatase activity
C5695_17240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5695_17245	COG0107	imidazoleglycerol-phosphate synthase activity
C5695_17250	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C5695_17255	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5695_17260	COG0131	Imidazoleglycerol-phosphate dehydratase
C5695_17265	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5695_17270	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C5695_17275	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C5695_17280	COG4990	cell redox homeostasis
C5695_17290	COG2910	NAD(P)H-binding
C5695_17295	COG1959	2 iron, 2 sulfur cluster binding
C5695_17300	COG0110	maltose O-acetyltransferase activity
C5695_17305	COG0546	phosphoglycolate phosphatase activity
C5695_17310	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C5695_17320	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C5695_17325	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C5695_17330	COG0363	glucosamine-6-phosphate deaminase activity
C5695_17340	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C5695_17345	COG1950	PFAM Membrane protein of
C5695_17350	COG1983	PspC domain protein
C5695_17355	COG3595	metallopeptidase activity
C5695_17370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C5695_17380	COG4897	Protein conserved in bacteria
C5695_17385	COG3848	Pyruvate phosphate dikinase
C5695_17385	COG0574	Belongs to the PEP-utilizing enzyme family
C5695_17390	COG1309	transcriptional regulator
C5695_17395	COG2814	Major facilitator Superfamily
C5695_17405	COG0745	RESPONSE REGULATOR receiver
C5695_17410	COG5002	protein histidine kinase activity
C5695_17415	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C5695_17420	COG0463	Glycosyl transferase, family 2
C5695_17425	COG1113	amino acid transport
C5695_17430	COG0778	Nitroreductase
C5695_17460	COG3409	Peptidoglycan-binding domain 1 protein
C5695_17460	COG5632	N-Acetylmuramoyl-L-alanine amidase
C5695_17505	COG3953	SLT domain
C5695_17505	COG5280	Phage tail tape measure protein TP901
C5695_17615	COG0305	Participates in initiation and elongation during chromosome replication
C5695_17665	COG1396	sequence-specific DNA binding
C5695_17675	COG0582	viral genome integration into host DNA
C5695_17680	COG1733	regulation of RNA biosynthetic process
C5695_17685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5695_17695	COG3409	Peptidoglycan-binding domain 1 protein
C5695_17695	COG0793	Belongs to the peptidase S41A family
C5695_17700	COG0730	response to heat
C5695_17705	COG3883	PFAM NLP P60 protein
C5695_17705	COG0791	NLP P60 protein
C5695_17710	COG2177	Part of the ABC transporter FtsEX involved in
C5695_17715	COG2884	Cell division ATP-binding protein ftsE
C5695_17720	COG2010	Cytochrome c
C5695_17725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C5695_17745	COG0653	protein targeting
C5695_17750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C5695_17755	COG0840	transmembrane signaling receptor activity
C5695_17770	COG1516	flagellar protein fliS
C5695_17775	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C5695_17780	COG1334	flagellar protein FlaG
C5695_17785	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C5695_17790	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C5695_17800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C5695_17805	COG1256	bacterial-type flagellum assembly
C5695_17805	COG4786	Flagellar basal body rod
C5695_17810	COG3418	PFAM FlgN family protein
C5695_17825	COG1040	competence protein
C5695_17835	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C5695_17840	COG1307	EDD domain protein, DegV family
C5695_17845	COG2197	response regulator
C5695_17850	COG4585	Histidine kinase
C5695_17855	COG1739	Uncharacterized protein family UPF0029
C5695_17860	COG1316	TRANSCRIPTIONal
C5695_17865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C5695_17870	COG0438	transferase activity, transferring glycosyl groups
C5695_17875	COG1215	transferase activity, transferring glycosyl groups
C5695_17880	COG3206	protein involved in exopolysaccharide biosynthesis
C5695_17885	COG3307	-O-antigen
C5695_17890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C5695_17895	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5695_17900	COG0297	glycogen (starch) synthase activity
C5695_17900	COG0438	transferase activity, transferring glycosyl groups
C5695_17905	COG2244	polysaccharide biosynthetic process
C5695_17920	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5695_17920	COG2247	cell wall binding repeat
C5695_17925	COG2385	sporulation resulting in formation of a cellular spore
C5695_17925	COG2247	cell wall binding repeat
C5695_17935	COG1316	TRANSCRIPTIONal
C5695_17945	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C5695_17950	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C5695_17955	COG1134	teichoic acid transport
C5695_17960	COG1682	transport, permease protein
C5695_17970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5695_17975	COG0438	transferase activity, transferring glycosyl groups
C5695_17980	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C5695_17985	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
C5695_17990	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5695_17995	COG4193	domain, Protein
C5695_18000	COG1482	cell wall glycoprotein biosynthetic process
C5695_18010	COG1175	transmembrane transport
C5695_18015	COG1653	transport
C5695_18020	COG2197	response regulator
C5695_18025	COG2972	Histidine kinase
C5695_18035	COG0454	-acetyltransferase
C5695_18040	COG0800	Aldolase
C5695_18050	COG1609	Transcriptional regulator
C5695_18055	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C5695_18060	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_18065	COG0697	spore germination
C5695_18070	COG0814	amino acid
C5695_18085	COG2814	Major facilitator Superfamily
C5695_18090	COG1316	TRANSCRIPTIONal
C5695_18095	COG0561	phosphatase activity
C5695_18100	COG0791	NLP P60 protein
C5695_18105	COG2843	Capsule synthesis protein
C5695_18115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C5695_18120	COG0697	spore germination
C5695_18135	COG1609	Transcriptional regulator
C5695_18140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C5695_18145	COG1869	D-ribose catabolic process
C5695_18150	COG1129	ABC transporter
C5695_18155	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5695_18160	COG1879	ABC-type sugar transport system periplasmic component
C5695_18165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C5695_18170	COG0583	DNA-binding transcription factor activity
C5695_18175	COG0028	Belongs to the TPP enzyme family
C5695_18180	COG3527	Alpha-acetolactate decarboxylase
C5695_18185	COG1522	sequence-specific DNA binding
C5695_18190	COG2059	Chromate
C5695_18195	COG2059	Chromate
C5695_18200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C5695_18205	COG4715	Zinc finger, swim domain protein
C5695_18210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C5695_18215	COG2202	Pas domain
C5695_18215	COG1366	Belongs to the anti-sigma-factor antagonist family
C5695_18220	COG0561	phosphatase activity
C5695_18235	COG1970	mechanosensitive ion channel activity
C5695_18240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C5695_18245	COG0457	Tetratricopeptide repeat
C5695_18250	COG4786	Flagellar basal body rod
C5695_18255	COG4786	Flagellar basal body rod
C5695_18260	COG1077	Cell shape determining protein MreB Mrl
C5695_18265	COG1609	Transcriptional regulator
C5695_18270	COG1846	Transcriptional regulator
C5695_18275	COG2814	Major facilitator Superfamily
C5695_18280	COG0671	phosphoesterase, PA-phosphatase related
C5695_18285	COG0477	Major facilitator Superfamily
C5695_18290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_18295	COG0765	amino acid transport
C5695_18300	COG1126	abc transporter atp-binding protein
C5695_18305	COG0004	ammonium transporteR
C5695_18310	COG0347	Belongs to the P(II) protein family
C5695_18315	COG0739	heme binding
C5695_18320	COG1247	-acetyltransferase
C5695_18360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C5695_18365	COG0523	cobalamin synthesis protein
C5695_18370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5695_18375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C5695_18380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C5695_18390	COG0243	molybdopterin cofactor binding
C5695_18395	COG2304	oxidoreductase activity
C5695_18400	COG2304	oxidoreductase activity
C5695_18405	COG2385	sporulation resulting in formation of a cellular spore
C5695_18410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5695_18420	COG4836	Membrane
C5695_18430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C5695_18435	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C5695_18440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C5695_18445	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C5695_18450	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5695_18455	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5695_18460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C5695_18465	COG0356	it plays a direct role in the translocation of protons across the membrane
C5695_18480	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C5695_18485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C5695_18490	COG4475	Protein of unknown function (DUF436)
C5695_18495	COG0698	ribose 5-phosphate isomerase
C5695_18500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C5695_18505	COG1971	Probably functions as a manganese efflux pump
C5695_18510	COG0009	L-threonylcarbamoyladenylate synthase
C5695_18515	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5695_18530	COG2890	protein-(glutamine-N5) methyltransferase activity
C5695_18535	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C5695_18540	COG0789	Transcriptional regulator
C5695_18545	COG0679	Auxin Efflux Carrier
C5695_18550	COG0281	malic enzyme
C5695_18555	COG1435	thymidine kinase activity
C5695_18560	COG0254	rRNA binding
C5695_18565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5695_18570	COG1494	fructose-1,6-bisphosphatase
C5695_18575	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C5695_18580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C5695_18585	COG0191	fructose-bisphosphate aldolase activity
C5695_18590	COG2204	response regulator
C5695_18595	COG4821	SIS domain
C5695_18600	COG0504	CTP synthase activity
C5695_18605	COG3343	RNA polymerase activity
C5695_18645	COG1960	acyl-CoA dehydrogenase activity
C5695_18650	COG1960	acyl-CoA dehydrogenase activity
C5695_18655	COG1250	3-hydroxyacyl-CoA dehydrogenase
C5695_18660	COG0183	Belongs to the thiolase family
C5695_18665	COG2181	nitrate reductase activity
C5695_18665	COG0247	lactate metabolic process
C5695_18670	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5695_18675	COG4294	response to UV
C5695_18685	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5695_18700	COG1132	(ABC) transporter
C5695_18705	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C5695_18710	COG1619	proteins homologs of microcin C7 resistance protein MccF
C5695_18725	COG0018	arginyl-trna synthetase
C5695_18730	COG4506	Protein conserved in bacteria
C5695_18740	COG0010	Belongs to the arginase family
C5695_18745	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C5695_18750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5695_18760	COG1994	Peptidase M50
C5695_18765	COG1942	4-Oxalocrotonate Tautomerase
C5695_18775	COG3465	dGTPase activity
C5695_18780	COG1078	dGTPase activity
C5695_18785	COG4844	belongs to the
C5695_18860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C5695_18870	COG0280	phosphate acetyltransferase
C5695_18880	COG2814	Major facilitator Superfamily
C5695_18885	COG1522	sequence-specific DNA binding
C5695_18890	COG2814	Major facilitator Superfamily
C5695_18895	COG0077	Prephenate dehydratase
C5695_18900	COG1917	Cupin 2, conserved barrel domain protein
C5695_18905	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_18910	COG0151	Belongs to the GarS family
C5695_18915	COG0436	Aminotransferase
C5695_18920	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_18925	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C5695_18930	COG1091	dTDP-4-dehydrorhamnose reductase activity
C5695_18935	COG1088	dTDP-glucose 4,6-dehydratase activity
C5695_18940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C5695_18945	COG3980	spore coat polysaccharide biosynthesis protein
C5695_18950	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C5695_18955	COG2089	acid synthase
C5695_18960	COG0456	acetyltransferase
C5695_18965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C5695_18970	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C5695_18975	COG0463	Glycosyl transferase, family 2
C5695_18995	COG2363	Small membrane protein
C5695_19000	COG2233	PERMEase
C5695_19010	COG1012	belongs to the aldehyde dehydrogenase family
C5695_19015	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C5695_19020	COG1216	Glycosyl transferase, family 2
C5695_19030	COG0351	phosphomethylpyrimidine kinase
C5695_19045	COG1621	beta-fructofuranosidase activity
C5695_19050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_19050	COG1263	PTS System
C5695_19055	COG3711	transcriptional antiterminator
C5695_19065	COG1404	Belongs to the peptidase S8 family
C5695_19075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C5695_19080	COG0778	Nitroreductase
C5695_19085	COG0772	Belongs to the SEDS family
C5695_19100	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5695_19105	COG1845	cytochrome c oxidase, subunit III
C5695_19110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5695_19115	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5695_19125	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C5695_19130	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C5695_19135	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C5695_19150	COG2246	polysaccharide biosynthetic process
C5695_19170	COG3162	membrane
C5695_19175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C5695_19190	COG0352	thiamine-phosphate diphosphorylase activity
C5695_19195	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C5695_19200	COG0583	DNA-binding transcription factor activity
C5695_19210	COG1346	cytolysis
C5695_19215	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5695_19220	COG0346	lactoylglutathione lyase activity
C5695_19230	COG0765	amino acid transport
C5695_19235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C5695_19240	COG0457	Tetratricopeptide repeat
C5695_19245	COG2357	RelA SpoT domain protein
C5695_19250	COG1172	Belongs to the binding-protein-dependent transport system permease family
C5695_19255	COG1129	ABC transporter
C5695_19265	COG3420	alginic acid biosynthetic process
C5695_19270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C5695_19280	COG1486	melibiose metabolic process
C5695_19285	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5695_19290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5695_19295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5695_19300	COG3711	transcriptional antiterminator
C5695_19300	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_19315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C5695_19330	COG1595	DNA-templated transcription, initiation
C5695_19335	COG3866	Pectate lyase
C5695_19340	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C5695_19345	COG4988	ABC transporter
C5695_19350	COG1294	oxidase, subunit
C5695_19355	COG1271	oxidase subunit
C5695_19365	COG1733	regulation of RNA biosynthetic process
C5695_19370	COG2514	catechol 2,3-dioxygenase activity
C5695_19375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5695_19375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5695_19380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5695_19380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5695_19390	COG0726	polysaccharide deacetylase
C5695_19395	COG1447	Phosphotransferase system cellobiose-specific component IIA
C5695_19400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5695_19405	COG2723	6-phospho-beta-galactosidase activity
C5695_19410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C5695_19415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5695_19415	COG3711	transcriptional antiterminator
C5695_19440	COG1757	Na H antiporter
C5695_19445	COG1027	Aspartate ammonia-lyase
C5695_19450	COG0252	asparaginase activity
C5695_19455	COG1396	sequence-specific DNA binding
C5695_19485	COG4842	Belongs to the WXG100 family
C5695_19490	COG2195	Cleaves the N-terminal amino acid of tripeptides
C5695_19500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5695_19505	COG2723	6-phospho-beta-galactosidase activity
C5695_19510	COG1263	PTS System
C5695_19510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_19510	COG2190	(PTS) system
C5695_19515	COG3711	transcriptional antiterminator
C5695_19520	COG3878	Protein conserved in bacteria
C5695_19530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5695_19535	COG1122	ATPase activity
C5695_19540	COG4721	ABC-type cobalt transport system, permease component
C5695_19545	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C5695_19570	COG4412	M6 family metalloprotease domain protein
C5695_19570	COG3291	Pkd domain containing protein
C5695_19575	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C5695_19580	COG0778	Nitroreductase
C5695_19585	COG1846	Transcriptional regulator
C5695_19590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C5695_19595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C5695_19600	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C5695_19605	COG2390	Transcriptional regulator
C5695_19615	COG2755	lipolytic protein G-D-S-L family
C5695_19615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C5695_19620	COG0477	Major facilitator Superfamily
C5695_19640	COG0561	phosphatase activity
C5695_19645	COG0789	Transcriptional regulator
C5695_19650	COG0673	inositol 2-dehydrogenase activity
C5695_19655	COG0840	transmembrane signaling receptor activity
C5695_19660	COG1113	amino acid transport
C5695_19665	COG4335	DNA alkylation repair
C5695_19680	COG1737	Transcriptional regulator
C5695_19715	COG0583	DNA-binding transcription factor activity
C5695_19720	COG1609	Transcriptional regulator
C5695_19725	COG2182	Extracellular solute-binding protein
C5695_19730	COG1175	transmembrane transport
C5695_19735	COG3833	ABC-type maltose transport systems, permease component
C5695_19745	COG1874	Beta-galactosidase
C5695_19750	COG2851	Citrate transporter
C5695_19760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C5695_19765	COG1131	(ABC) transporter
C5695_19770	COG2824	Alkylphosphonate utilization operon protein PhnA
C5695_19775	COG1929	Belongs to the glycerate kinase type-1 family
C5695_19780	COG2610	gluconate transmembrane transporter activity
C5695_19785	COG3835	regulator
C5695_19790	COG1309	transcriptional regulator
C5695_19795	COG2814	Major facilitator Superfamily
C5695_19805	COG1136	(ABC) transporter
C5695_19815	COG0457	Tetratricopeptide repeat
C5695_19820	COG3711	transcriptional antiterminator
C5695_19825	COG2723	6-phospho-beta-galactosidase activity
C5695_19830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5695_19830	COG1263	PTS System
C5695_19830	COG2190	(PTS) system
C5695_19850	COG0494	nUDIX hydrolase
C5695_19865	COG1113	amino acid transport
C5695_19875	COG2814	Major facilitator Superfamily
C5695_19880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C5695_19885	COG2814	Major facilitator Superfamily
C5695_19905	COG5444	nuclease activity
C5695_19920	COG2723	6-phospho-beta-galactosidase activity
C5695_19930	COG2188	Transcriptional regulator
C5695_19940	COG0384	phenazine biosynthesis protein PhzF
C5695_19945	COG0583	DNA-binding transcription factor activity
C5695_20010	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C5695_20020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C5695_20030	COG4720	Psort location CytoplasmicMembrane, score
C5695_20055	COG0456	acetyltransferase
C5695_20060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5695_20065	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C5695_20070	COG4853	Protein conserved in bacteria
C5695_20075	COG4863	YycH protein
C5695_20080	COG5002	protein histidine kinase activity
C5695_20085	COG0745	RESPONSE REGULATOR receiver
C5695_20110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C5695_20120	COG2311	Membrane
C5695_20125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C5695_20135	COG2124	cytochrome p450
C5695_20140	COG0346	lactoylglutathione lyase activity
C5695_20145	COG0305	Participates in initiation and elongation during chromosome replication
C5695_20170	COG2819	hydrolase of the alpha beta superfamily
C5695_20175	COG1028	Short-chain dehydrogenase reductase Sdr
C5695_20180	COG1169	isochorismate synthase
C5695_20185	COG1021	2,3-dihydroxybenzoate-AMP ligase
C5695_20190	COG1535	isochorismatase
C5695_20190	COG3433	isochorismatase activity
C5695_20195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C5695_20200	COG3251	PFAM MbtH domain protein
C5695_20205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_20205	COG2207	Transcriptional regulator
C5695_20210	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C5695_20215	COG2819	hydrolase of the alpha beta superfamily
C5695_20220	COG3093	addiction module antidote protein HigA
C5695_20225	COG2807	transmembrane transport
C5695_20230	COG0359	binds to the 23S rRNA
C5695_20235	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C5695_20240	COG4241	membrane
C5695_20245	COG1227	inorganic diphosphatase activity
C5695_20255	COG1595	DNA-templated transcription, initiation
C5695_20270	COG0655	NAD(P)H dehydrogenase (quinone) activity
C5695_20275	COG0400	carboxylic ester hydrolase activity
C5695_20280	COG0346	lactoylglutathione lyase activity
C5695_20285	COG1174	glycine betaine transport
C5695_20290	COG0517	IMP dehydrogenase activity
C5695_20290	COG1125	glycine betaine transport
C5695_20295	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C5695_20300	COG0629	single-stranded DNA binding
C5695_20305	COG0360	Binds together with S18 to 16S ribosomal RNA
C5695_20310	COG0012	GTP binding
C5695_20315	COG4481	Protein conserved in bacteria
C5695_20330	COG3949	Membrane
C5695_20340	COG1475	DNA binding
C5695_20345	COG1192	Involved in chromosome partitioning
C5695_20355	COG1475	DNA binding
C5695_20360	COG0357	Ribosomal RNA small subunit methyltransferase G
C5695_20365	COG0445	tRNA wobble uridine modification
C5695_20370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5695_20375	COG1847	R3H domain protein
C5695_20380	COG0706	membrane insertase activity
C5695_20385	COG0594	ribonuclease P activity
C5695_20390	COG0230	Belongs to the bacterial ribosomal protein bL34 family