locus-tag class description C5Y82_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C5Y82_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C5Y82_00015 ENOG410848D S4 domain protein YaaA C5Y82_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) C5Y82_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5Y82_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5Y82_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C5Y82_00080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5Y82_00085 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C5Y82_00090 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C5Y82_00095 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C5Y82_00100 ENOG4105FKZ Methyl-accepting chemotaxis C5Y82_00110 ENOG4105ZMH deoxynucleoside kinase C5Y82_00120 ENOG4105VRS hydrolase family 18 C5Y82_00125 ENOG4105GTG Isochorismatase C5Y82_00130 ENOG4108Z6B deaminase C5Y82_00140 ENOG4105C6E dna polymerase iii C5Y82_00145 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C5Y82_00150 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C5Y82_00160 ENOG41067KS pro-sigma K processing C5Y82_00200 ENOG4105CDW Resistance protein C5Y82_00205 ENOG4105CXN decarboxylase C5Y82_00210 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C5Y82_00215 ENOG4105X0R protein from nitrogen regulatory protein P-II C5Y82_00220 ENOG4105XVJ Protein of unknown function (DUF327) C5Y82_00225 ENOG4105FA2 dna polymerase iii C5Y82_00230 ENOG4105MA4 psp1 domain protein C5Y82_00235 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) C5Y82_00240 ENOG41060K3 Methyltransferase C5Y82_00245 ENOG4105VC4 domain protein C5Y82_00250 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C5Y82_00255 ENOG4105KRN Transcriptional regulator, abrb family C5Y82_00260 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C5Y82_00265 ENOG4105F8V Hydrolase, tatD family C5Y82_00270 ENOG41069ER domain protein C5Y82_00280 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C5Y82_00285 ENOG4105XFA sporulation peptidase YabG C5Y82_00290 ENOG4105W42 Veg protein C5Y82_00295 ENOG4105XEW small acid-soluble spore protein C5Y82_00300 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C5Y82_00305 ENOG4105DFT pur operon repressor C5Y82_00310 ENOG4105KME endoribonuclease L-psp C5Y82_00320 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C5Y82_00325 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C5Y82_00330 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C5Y82_00335 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C5Y82_00345 ENOG4108JA2 transcriptioN-repair coupling factor C5Y82_00350 ENOG4108M14 stage v sporulation protein t C5Y82_00360 ENOG4108IY2 MazG family C5Y82_00365 ENOG41082I2 s4 domain protein C5Y82_00370 ENOG4105VYY sporulation protein yabp C5Y82_00385 ENOG41060GV RNA binding s1 domain protein C5Y82_00415 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C5Y82_00420 ENOG4108UGV hypoxanthine phosphoribosyltransferase C5Y82_00425 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C5Y82_00430 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) C5Y82_00435 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C5Y82_00440 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C5Y82_00445 ENOG4105C6T cysteine synthase C5Y82_00450 ENOG4105CRQ synthase (Component I) C5Y82_00455 ENOG4105DDQ anthranilate synthase C5Y82_00460 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C5Y82_00465 ENOG4105EEI dihydropteroate synthase C5Y82_00470 ENOG4105KRF dihydroneopterin aldolase C5Y82_00475 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C5Y82_00485 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C5Y82_00490 ENOG4105CRK lysyL-tRNA synthetase C5Y82_00575 ENOG4108Z0C Uvrb UvrC protein C5Y82_00580 ENOG41066A3 ATP guanido phosphotransferase C5Y82_00590 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C5Y82_00595 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C5Y82_00600 ENOG4105CTP PilT protein domain protein C5Y82_00605 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C5Y82_00610 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C5Y82_00615 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C5Y82_00620 ENOG4105D7W serine acetyltransferase C5Y82_00625 ENOG4105C8N cysteinyl-tRNA synthetase C5Y82_00630 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C5Y82_00635 ENOG4105C2N RNA methyltransferase TrmH family group 3 C5Y82_00640 ENOG4105M0M Tetracycline resistance protein C5Y82_00660 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C5Y82_00665 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) C5Y82_00670 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) C5Y82_00675 ENOG4108VZM 50s ribosomal protein L10 C5Y82_00680 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) C5Y82_00685 ENOG4107Y49 methyltransferase C5Y82_00690 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5Y82_00695 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5Y82_00700 ENOG4105XPM ribosomal protein C5Y82_00705 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C5Y82_00710 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C5Y82_00715 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C5Y82_00725 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C5Y82_00730 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C5Y82_00735 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C5Y82_00740 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C5Y82_00745 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) C5Y82_00750 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C5Y82_00755 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) C5Y82_00760 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) C5Y82_00765 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C5Y82_00770 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C5Y82_00775 ENOG41082SA 50s ribosomal protein l29 C5Y82_00780 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C5Y82_00785 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C5Y82_00790 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) C5Y82_00795 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C5Y82_00800 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C5Y82_00805 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C5Y82_00810 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C5Y82_00815 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C5Y82_00820 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C5Y82_00825 ENOG4105VPB 50S ribosomal protein L30 C5Y82_00830 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C5Y82_00835 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C5Y82_00840 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C5Y82_00845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C5Y82_00855 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) C5Y82_00865 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C5Y82_00870 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C5Y82_00875 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C5Y82_00880 ENOG4108ZT0 50S ribosomal protein l17 C5Y82_00885 ENOG4108JJB ABC transporter C5Y82_00890 ENOG4108JJB ABC transporter C5Y82_00895 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C5Y82_00900 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C5Y82_00905 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C5Y82_00910 ENOG4108UJD 30S ribosomal protein S9 C5Y82_00950 ENOG4105D1F ATP-binding protein C5Y82_00965 ENOG4108NMV polysaccharide deacetylase C5Y82_00995 ENOG4105I03 Flagellin C5Y82_01000 ENOG4105CHH sulfate transporter C5Y82_01010 ENOG4105EHZ conserved protein UCP016719 C5Y82_01015 ENOG4105D17 glycoside hydrolase, family 3 domain protein C5Y82_01035 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C5Y82_01070 ENOG4105EMN RNA polymerase sigma factor C5Y82_01080 ENOG4105C8B TIGR00159 family C5Y82_01085 ENOG4107U5W ybbr family C5Y82_01090 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C5Y82_01100 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C5Y82_01115 ENOG4105DA5 (ABC) transporter C5Y82_01160 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C5Y82_01165 ENOG4105CXY transporter C5Y82_01170 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C5Y82_01175 ENOG4105C7Z Conserved Protein C5Y82_01195 ENOG4105XTG Pfam:DUF156 C5Y82_01200 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C5Y82_01205 ENOG4105WZW rhodanese family C5Y82_01210 ENOG4105VFE sira family C5Y82_01215 ENOG4107TPS domain protein C5Y82_01220 ENOG4105VFE sira family C5Y82_01225 ENOG41087NI Sulfite exporter TauE/SafE C5Y82_01230 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) C5Y82_01235 ENOG4108SUT Major Facilitator Superfamily C5Y82_01255 ENOG4105EWC Purine nucleoside phosphorylase C5Y82_01270 ENOG4107SCQ Iron-containing alcohol dehydrogenase C5Y82_01275 ENOG4105C72 UPF0176 protein C5Y82_01280 ENOG4107QTZ amino acid C5Y82_01290 ENOG4105CID antiterminator C5Y82_01295 ENOG4105C5Y PTS System C5Y82_01300 ENOG4105CS2 ec 3.2.1.21 C5Y82_01325 ENOG4105EMD TRANSCRIPTIONal C5Y82_01330 ENOG4105EVU fructokinase C5Y82_01335 ENOG4105C8I hydrolase, family 38 C5Y82_01340 ENOG4105DM4 PTS System C5Y82_01345 ENOG4108YRF PTS System C5Y82_01350 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein C5Y82_01355 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5Y82_01370 ENOG4108IQI permease C5Y82_01375 ENOG4108J5H Homocysteine s-methyltransferase C5Y82_01380 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C5Y82_01395 ENOG4105C2C drug resistance transporter, Bcr CflA C5Y82_01415 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C5Y82_01425 ENOG4105J7D transcriptional regulator C5Y82_01435 ENOG4105E2A Dehydrogenase C5Y82_01440 ENOG41067TZ transcriptional regulator, MarR family C5Y82_01450 ENOG4105CUB amino acid C5Y82_01460 ENOG4105D74 hydrolase C5Y82_01470 ENOG4105CSV Glutaminase C5Y82_01485 ENOG41060AI SEC-C motif C5Y82_01495 ENOG4107SET aldo keto reductase C5Y82_01505 ENOG4107Y7X LytTR C5Y82_01510 ENOG4108IUW ABC transporter C5Y82_01515 ENOG4108SDH ABC, transporter C5Y82_01535 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C5Y82_01545 ENOG4105DEN Luciferase family C5Y82_01550 ENOG4108N0M stress protein C5Y82_01555 ENOG4106FN3 tellurium resistance protein C5Y82_01560 ENOG4106FN3 tellurium resistance protein C5Y82_01565 ENOG4107TS3 membrane protein, TerC C5Y82_01590 ENOG4108TTB tellurium resistance protein C5Y82_01600 ENOG4108IJ7 Glycine betaine C5Y82_01605 ENOG4107SQ8 Glycine betaine C5Y82_01635 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C5Y82_01655 ENOG4105TRI Hydrolase C5Y82_01690 ENOG4105EIG urea carboxylase-associated protein 1 C5Y82_01695 ENOG4107RMH nh(3)-dependent nad( ) synthetase C5Y82_01700 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C5Y82_01710 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Y82_01715 ENOG4105ETE Transcriptional regulator (LacI family C5Y82_01720 ENOG41079KZ Major Facilitator Superfamily C5Y82_01725 ENOG41089UC methyltransferase, type 11 C5Y82_01730 ENOG4105C5Q Transcriptional regulator C5Y82_01735 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C5Y82_01740 ENOG4105I82 acetyl xylan esterase C5Y82_01750 ENOG410756H nucleotidyltransferase C5Y82_01760 ENOG4105C26 Dehydrogenase C5Y82_01765 ENOG4107YHD transcriptional regulator C5Y82_01770 ENOG4107R5R arsenical pump membrane protein C5Y82_01775 ENOG4105E5Q amino acid AbC transporter C5Y82_01780 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein C5Y82_01790 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein C5Y82_01800 ENOG4108AQF aminoglycoside N(3)-acetyltransferase C5Y82_01810 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_01840 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C5Y82_01845 ENOG4105F38 ABC transporter, permease C5Y82_01855 ENOG4105CEY Amp-dependent synthetase and ligase C5Y82_01885 ENOG4105SX7 Transporter C5Y82_01925 ENOG4105CDA abc transporter atp-binding protein C5Y82_01930 ENOG4105DRP amino acid AbC transporter C5Y82_01945 ENOG4108IQI permease C5Y82_01950 ENOG4105DUX Transporter C5Y82_01960 ENOG4105CPU Monooxygenase C5Y82_01965 ENOG4108XSB acetyltransferase, (GNAT) family C5Y82_01970 ENOG4105EAB amino acid AbC transporter C5Y82_01975 ENOG4108HW4 amino acid AbC transporter C5Y82_01985 ENOG4105CH2 amidohydrolase C5Y82_01990 ENOG4108PGP mmge prpd family protein C5Y82_01995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Y82_02000 ENOG4105BZU Histidine kinase C5Y82_02010 ENOG4105CFH Aspartokinase C5Y82_02020 ENOG4105R8C Transcriptional regulator C5Y82_02030 ENOG4105YVS arsR family transcriptional regulator C5Y82_02040 ENOG4108JPW Aminotransferase C5Y82_02045 ENOG4107QTZ amino acid C5Y82_02050 ENOG4105C26 Dehydrogenase C5Y82_02055 ENOG4105DYS nad(p)h dehydrogenase (quinone) C5Y82_02060 ENOG4105KTB nuclear export factor GLE1 C5Y82_02065 ENOG4108T5E Copper resistance protein C5Y82_02080 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase C5Y82_02085 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_02110 ENOG4105X3H Excalibur domain protein C5Y82_02120 ENOG4105E7W lamb ycsf family protein C5Y82_02125 ENOG4105C5A transporter C5Y82_02130 ENOG4105CFM UPF0317 protein C5Y82_02135 ENOG4105P4J Allophanate hydrolase, subunit 1 C5Y82_02145 ENOG4107258 Transcriptional regulator C5Y82_02150 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5Y82_02155 ENOG4105XJB lipolytic protein G-D-S-L family C5Y82_02165 ENOG4105ETD TRANSCRIPTIONal C5Y82_02170 ENOG4105HMZ Methyltransferase C5Y82_02175 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5Y82_02180 ENOG410606W general stress protein C5Y82_02205 ENOG4105VCH membrane C5Y82_02210 ENOG4105DRR Transcriptional regulator, GntR family C5Y82_02215 ENOG410631K Membrane C5Y82_02220 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5Y82_02225 ENOG4105C9U ATP-dependent DNA helicase RecQ C5Y82_02240 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C5Y82_02245 ENOG4107R8N Glycosyl transferase, family 2 C5Y82_02255 ENOG4105C0X amino acid C5Y82_02290 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C5Y82_02295 ENOG4107BMA Transglycosylase associated protein C5Y82_02300 ENOG4105EU9 C5Y82_02305 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C5Y82_02310 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C5Y82_02315 ENOG4108MRH transcriptional regulatory protein C5Y82_02320 ENOG4107QJT sodium dicarboxylate symporter C5Y82_02325 ENOG4106F5Q Membrane C5Y82_02335 ENOG4105CJ1 ABC, transporter C5Y82_02355 ENOG4105SZ6 Thioredoxin C5Y82_02360 ENOG4105CPF Cell wall formation (By similarity) C5Y82_02365 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C5Y82_02380 ENOG4105C1J atp-dependent rna helicase C5Y82_02385 ENOG410905X membrane-flanked domain protein C5Y82_02390 ENOG4105CKV Membrane C5Y82_02405 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C5Y82_02410 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C5Y82_02420 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C5Y82_02425 ENOG4107MMM Anti-sigma-factor antagonist C5Y82_02430 ENOG4105FUA antagonist C5Y82_02435 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C5Y82_02440 ENOG4107SGM protein serine threonine phosphatase C5Y82_02445 ENOG4105WN5 stage II sporulation protein C5Y82_02450 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C5Y82_02460 ENOG41064BQ Phosphatase C5Y82_02480 ENOG4107RUY (E1 component), alpha subunit C5Y82_02490 ENOG4107QKR Dehydrogenase C5Y82_02500 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C5Y82_02560 ENOG4105VEQ Cold shock protein C5Y82_02565 ENOG4108VJ1 Transcriptional regulator (CarD family C5Y82_02570 ENOG4105DQ4 alcohol dehydrogenase C5Y82_02575 ENOG4105VUF Transcriptional regulator C5Y82_02590 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5Y82_02610 ENOG4105DUM transcriptional regulator, lysR family C5Y82_02645 ENOG4107RB3 L-asparaginase C5Y82_02660 ENOG4108IG5 Transcriptional regulator C5Y82_02670 ENOG4105H93 Acyltransferase family C5Y82_02675 ENOG4105EYF MMPL domain protein C5Y82_02680 ENOG4105ENE Histidine kinase C5Y82_02685 ENOG4108VB1 regulatoR C5Y82_02705 ENOG4105VDT -acetyltransferase C5Y82_02710 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase C5Y82_02720 ENOG4105ST3 Transcriptional regulator C5Y82_02725 ENOG4105NAE bifunctional deaminase-reductase domain protein C5Y82_02730 ENOG41090MY MarR family Transcriptional regulator C5Y82_02735 ENOG4108TVJ Nitroreductase C5Y82_02750 ENOG4108JCI Transcriptional regulator C5Y82_02760 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C5Y82_02765 ENOG4106NZI LysR family Transcriptional regulator C5Y82_02770 ENOG4105CPC Aldo Keto reductase C5Y82_02790 ENOG4108UMN azlc family C5Y82_02845 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C5Y82_02850 ENOG4105K8N protein family UPF0079, ATPase C5Y82_02855 ENOG41072GX Peptidase M22 Glycoprotease C5Y82_02860 ENOG410801F ribosomal-protein-alanine acetyltransferase C5Y82_02865 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C5Y82_02870 ENOG4105C5H ABC transporter C5Y82_02875 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C5Y82_02880 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C5Y82_02885 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C5Y82_02890 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C5Y82_02905 ENOG4108TYN CAAX amino terminal protease family protein C5Y82_02910 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) C5Y82_02915 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C5Y82_02950 ENOG4107STQ Multicopper oxidase C5Y82_02955 ENOG4105C85 amino acid C5Y82_02965 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C5Y82_02980 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) C5Y82_02990 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C5Y82_03010 ENOG4105KNA -acetyltransferase C5Y82_03020 ENOG4105JVQ RNA Polymerase C5Y82_03030 ENOG4108RWP Major Facilitator Superfamily protein C5Y82_03035 ENOG4105GZI Transcriptional regulator C5Y82_03040 ENOG4105C7N Xanthine uracil vitamin C permease C5Y82_03050 ENOG4108U5N UPF0316 protein C5Y82_03060 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C5Y82_03065 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C5Y82_03070 ENOG4105C83 adenylosuccinate lyase C5Y82_03075 ENOG4105C8V SAICAR synthetase C5Y82_03080 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C5Y82_03090 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C5Y82_03100 ENOG4105CXB phosphoribosylaminoimidazole synthetase C5Y82_03105 ENOG4108V3E phosphoribosylglycinamide formyltransferase C5Y82_03110 ENOG4105DC1 bifunctional purine biosynthesis protein purh C5Y82_03115 ENOG4105C12 Phosphoribosylglycinamide synthetase C5Y82_03135 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C5Y82_03150 ENOG4107S4Y M20 DapE family protein YgeY C5Y82_03165 ENOG4105KGF protein, YerC YecD C5Y82_03170 ENOG4105CBC glutamate synthase C5Y82_03185 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) C5Y82_03190 ENOG4105C4R Atp-dependent dna helicase C5Y82_03195 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C5Y82_03230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C5Y82_03245 ENOG4105C1G acyl-Coa dehydrogenase C5Y82_03265 ENOG4107SQU synthase C5Y82_03275 ENOG4105CRN Aminoglycoside phosphotransferase C5Y82_03280 ENOG4105G6Z alkaline phosphatase C5Y82_03285 ENOG4105KT7 mgtC SapB transporter C5Y82_03290 ENOG4105CK7 Sodium proline symporter C5Y82_03295 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5Y82_03300 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C5Y82_03305 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C5Y82_03315 ENOG4108IG5 Transcriptional regulator C5Y82_03325 ENOG4105DU0 nucleoside hydrolase C5Y82_03330 ENOG4105CBD Diacylglycerol kinase C5Y82_03335 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C5Y82_03340 ENOG41069I7 C5Y82_03370 ENOG41062ES Transcriptional regulator C5Y82_03375 ENOG4105C3M thioredoxin reductase C5Y82_03390 ENOG4105F8D glycoside hydrolase family 4 C5Y82_03395 ENOG4105HX0 Transcriptional regulator C5Y82_03410 ENOG4105DUM transcriptional regulator, lysR family C5Y82_03420 ENOG4108R1P C5Y82_03430 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C5Y82_03440 ENOG41090R9 glycosyltransferase C5Y82_03445 ENOG4107R51 Glycosyl transferase, family 2 C5Y82_03450 ENOG41090R9 glycosyltransferase C5Y82_03455 ENOG4105EU0 Major facilitator Superfamily C5Y82_03460 ENOG4107RVG penicillin-binding protein C5Y82_03465 ENOG4105C8P )-transporter C5Y82_03495 ENOG4105CUB amino acid C5Y82_03500 ENOG4107TVC Glycosyl transferase, family 2 C5Y82_03505 ENOG4105C5H ABC transporter C5Y82_03515 ENOG4107SWG transcriptional regulator MERR family C5Y82_03520 ENOG4105DXB Major Facilitator superfamily C5Y82_03525 ENOG4105C5H ABC transporter C5Y82_03530 ENOG4105FDU atp-dependent rna helicase C5Y82_03535 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C5Y82_03555 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5Y82_03560 ENOG4105E6M Sulphatase-modifying factor protein C5Y82_03570 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C5Y82_03585 ENOG4108MRH transcriptional regulatory protein C5Y82_03605 ENOG4105PY6 Phenolic acid decarboxylase C5Y82_03610 ENOG4105U3E Transcriptional regulator C5Y82_03620 ENOG41084AG Acylphosphatase C5Y82_03625 ENOG4108RPX mosc domain containing protein C5Y82_03635 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C5Y82_03645 ENOG4105NX3 Membrane C5Y82_03665 ENOG4105DY8 decarboxylase C5Y82_03680 ENOG4105C5Y PTS System C5Y82_03685 ENOG4105CG3 alpha amylase, catalytic region C5Y82_03690 ENOG4107414 GntR family transcriptional regulator C5Y82_03695 ENOG4108V4B ThiJ pfpI C5Y82_03705 ENOG4105CGH 5'-nucleotidase C5Y82_03710 ENOG4107RKG DJ-1/PfpI family C5Y82_03720 ENOG4105BZG amino acid carrier protein C5Y82_03730 ENOG4105KJF protein tyrosine phosphatase C5Y82_03740 ENOG4107U9T Pfam:Ribonuclease_BN C5Y82_03745 ENOG4108ISG Major Facilitator C5Y82_03755 ENOG4105UPD Calcium Proton C5Y82_03765 ENOG4105CDY transcriptional regulatory protein C5Y82_03775 ENOG4105D8X mechanosensitive ion channel C5Y82_03800 ENOG4105D7N magnesium and cobalt transport protein CorA C5Y82_03815 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C5Y82_03820 ENOG4108IG5 Transcriptional regulator C5Y82_03840 ENOG4107TXC Transcriptional regulator C5Y82_03860 ENOG4105C22 threonyL-tRNA synthetase C5Y82_03905 ENOG410839T multidrug resistance protein C5Y82_03925 ENOG4107TDE lipolytic protein G-D-S-L family C5Y82_03945 ENOG4105BZ1 (ABC) transporter C5Y82_03950 ENOG4105KK4 UPF0060 membrane protein C5Y82_03955 ENOG4105K6V RNA polymerase C5Y82_03975 ENOG4108YYS metal-dependent hydrolase (By similarity) C5Y82_03985 ENOG410834F Transcriptional regulator C5Y82_04015 ENOG4107Y03 Nitroreductase C5Y82_04035 ENOG4105KC9 Modulates RecA activity (By similarity) C5Y82_04060 ENOG4105CKK Glycosyl transferase, family 2 C5Y82_04065 ENOG4105EJV Membrane C5Y82_04085 ENOG4105F0F Oxalate decarboxylase C5Y82_04095 ENOG4106DF4 Sigma-70, region 4 C5Y82_04105 ENOG41067AE Membrane-bound metal-dependent hydrolase C5Y82_04110 ENOG4105CEN a g-specific adenine glycosylase C5Y82_04115 ENOG4106BXE C5Y82_04120 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C5Y82_04135 ENOG4105EVI UPF0374 protein C5Y82_04140 ENOG4105BZ1 (ABC) transporter C5Y82_04145 ENOG4105C3U ABC transporter C5Y82_04150 ENOG4108JQ7 (ABC) transporter C5Y82_04155 ENOG4105DEF Extracellular solute-binding protein, family 5 C5Y82_04160 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5Y82_04165 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Y82_04175 ENOG4107NBY Membrane C5Y82_04180 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C5Y82_04185 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5Y82_04190 ENOG4105G5W regulator Fur family C5Y82_04345 ENOG4105E0M Sulfatase C5Y82_04365 ENOG4105CJ1 ABC, transporter C5Y82_04400 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C5Y82_04410 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C5Y82_04420 ENOG4105CYN Serine protein kinase C5Y82_04425 ENOG4106AKX UPF0229 protein C5Y82_04430 ENOG4105CW7 secretion protein, HlyD family C5Y82_04435 ENOG4105C0R drug resistance transporter emrb qaca subfamily C5Y82_04440 ENOG4105CS1 NAD(P)H quinone oxidoreductase C5Y82_04450 ENOG4105VEQ Cold shock protein C5Y82_04460 ENOG4105BZU Histidine kinase C5Y82_04490 ENOG4105BZU Histidine kinase C5Y82_04510 ENOG4108YBP pseudouridine synthase C5Y82_04520 ENOG4107YBY Hydrolase C5Y82_04525 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C5Y82_04540 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR C5Y82_04545 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C5Y82_04550 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C5Y82_04560 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C5Y82_04565 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C5Y82_04580 ENOG4105BZU Histidine kinase C5Y82_04585 ENOG4105WH1 Two component transcriptional regulator luxr family C5Y82_04605 ENOG4105CH6 catalase C5Y82_04610 ENOG4105KPV Transcriptional regulator C5Y82_04615 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C5Y82_04620 ENOG4105ED1 spovr family C5Y82_04625 ENOG4105G6Z alkaline phosphatase C5Y82_04640 ENOG4105J37 C5Y82_04645 ENOG4108AEY RNA polymerase sigma factor C5Y82_04650 ENOG4105F6E Acyl-transferase C5Y82_04655 ENOG4105C37 (CBS) domain C5Y82_04665 ENOG4105C37 (CBS) domain C5Y82_04675 ENOG4106A8V Protein CrcB homolog C5Y82_04680 ENOG4105WMR Protein CrcB homolog C5Y82_04685 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Y82_04700 ENOG4105D64 Mechanosensitive ion channel C5Y82_04705 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C5Y82_04710 ENOG4107VMI polysaccharide deacetylase C5Y82_04715 ENOG4105F0I Aminotransferase C5Y82_04730 ENOG4105BZ1 (ABC) transporter C5Y82_04760 ENOG410839P C5Y82_04770 ENOG4108UH6 UPF0754 membrane protein C5Y82_04775 ENOG4105WZB UPF0342 protein C5Y82_04785 ENOG4105D4P Coproporphyrinogen iii oxidase C5Y82_04795 ENOG4105CGU Enoyl-CoA hydratase C5Y82_04805 ENOG4107VRP DNA repair exonuclease C5Y82_04810 ENOG4106D4I domain protein C5Y82_04825 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C5Y82_04870 ENOG4105NBU tryptophan transport protein C5Y82_04875 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C5Y82_04880 ENOG4105K59 histidine triad (HIT) protein C5Y82_04910 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C5Y82_04915 ENOG4105BZ4 penicillin-binding protein C5Y82_04920 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C5Y82_04925 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C5Y82_04930 ENOG4105C1Q protoporphyrinogen oxidase C5Y82_04940 ENOG4105ECB domain protein C5Y82_04945 ENOG4105DER m42 family C5Y82_04955 ENOG4106AXD C5Y82_04960 ENOG4108RQ5 Beta-lactamase domain-containing protein C5Y82_04965 ENOG4105DF9 Lipoate-protein, ligase C5Y82_04970 ENOG4105CEY Amp-dependent synthetase and ligase C5Y82_04980 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C5Y82_04985 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5Y82_04990 ENOG4107TB6 phosphoglycerate mutase C5Y82_04995 ENOG4106YBV Methyl-accepting chemotaxis C5Y82_05015 ENOG4105XVF Competence transcription factor C5Y82_05030 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C5Y82_05035 ENOG4105E5M Multidrug resistance protein D C5Y82_05040 ENOG41067XF inhibitor C5Y82_05045 ENOG4105DHS permease protein C5Y82_05050 ENOG4105CM4 permease protein C5Y82_05055 ENOG4108IPW abc transporter atp-binding protein C5Y82_05065 ENOG4108KGH TRANSCRIPTIONal C5Y82_05070 ENOG41060YP C5Y82_05085 ENOG4108KK1 membrane protein AbrB duplication C5Y82_05095 ENOG4105D0M Protease HtpX homolog C5Y82_05115 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C5Y82_05125 ENOG4105EYH Exonuclease C5Y82_05180 ENOG4105ERH Fumarylacetoacetate hydrolase C5Y82_05185 ENOG4106BKT UPF0344 protein C5Y82_05195 ENOG4105CAQ asparagine synthetase C5Y82_05215 ENOG4105UQX Mate efflux family protein C5Y82_05220 ENOG4106HBX Transcriptional Regulator AraC Family C5Y82_05250 ENOG4105DY8 decarboxylase C5Y82_05290 ENOG4108VPT UPF0234 protein C5Y82_05295 ENOG4105QNR S1 RNA binding domain protein C5Y82_05300 ENOG4105DIH basic membrane C5Y82_05305 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_05310 ENOG4105EPR degv family C5Y82_05315 ENOG4107AYK membrAne C5Y82_05325 ENOG41073B9 C5Y82_05335 ENOG4108KP7 hydrolase C5Y82_05340 ENOG4108MXZ Esterase C5Y82_05345 ENOG4105VG1 fes assembly suf system protein C5Y82_05350 ENOG4105IQ5 FAD linked oxidase domain protein C5Y82_05360 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C5Y82_05370 ENOG4105CAS nag kinase C5Y82_05375 ENOG4105C8Y Acetylornithine aminotransferase C5Y82_05380 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C5Y82_05390 ENOG4105DBV ornithine carbamoyltransferase C5Y82_05420 ENOG4107RMD Basic membrane lipoprotein C5Y82_05435 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C5Y82_05440 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C5Y82_05450 ENOG4105C3U ABC transporter C5Y82_05455 ENOG4108JQ7 (ABC) transporter C5Y82_05470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Y82_05490 ENOG4105C31 Tryptophanyl-tRNA synthetase C5Y82_05505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5Y82_05510 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Y82_05520 ENOG4108JQ7 (ABC) transporter C5Y82_05535 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C5Y82_05540 ENOG4108ZCF integral membrane protein C5Y82_05545 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C5Y82_05550 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C5Y82_05560 ENOG4105DPN Oligoendopeptidase f C5Y82_05565 ENOG4105T58 Dithiol-disulfide isomerase C5Y82_05570 ENOG4108Z18 K06886 hemoglobin C5Y82_05575 ENOG4105E4C Lytic transglycosylase catalytic C5Y82_05580 ENOG4105MIX Adenylate cyclase C5Y82_05585 ENOG4106EFP UPF0738 protein C5Y82_05595 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C5Y82_05600 ENOG4105EMS pseudouridine synthase C5Y82_05605 ENOG4107S1Q Phosphatase C5Y82_05615 ENOG4105ETU transcriptional activator (TenA C5Y82_05620 ENOG4108VEU Thiamine monophosphate synthase C5Y82_05635 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C5Y82_05640 ENOG4105D06 uba thif-type nad fad binding protein C5Y82_05645 ENOG4105DWF phosphomethylpyrimidine kinase C5Y82_05650 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C5Y82_05655 ENOG4107A88 C5Y82_05705 ENOG4105ENA helicase C5Y82_05730 ENOG4105C28 cystathionine C5Y82_05735 ENOG4105C28 cystathionine C5Y82_05765 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) C5Y82_05835 ENOG4105DUM transcriptional regulator, lysR family C5Y82_05850 ENOG4107V2S Transcriptional regulator C5Y82_05855 ENOG4105DJ2 Major Facilitator Superfamily C5Y82_05890 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C5Y82_05905 ENOG4105I03 Flagellin C5Y82_05910 ENOG4105I03 Flagellin C5Y82_05915 ENOG4105I03 Flagellin C5Y82_05920 ENOG4105I03 Flagellin C5Y82_05945 ENOG410635T phage-like element pbsx protein C5Y82_05950 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C5Y82_05965 ENOG4105CJ3 phosphate transporter C5Y82_05970 ENOG4107GRR phosphate transport regulator C5Y82_05980 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C5Y82_05995 ENOG4105DT3 PTS system, galactitol-specific IIc component C5Y82_06010 ENOG4105CPQ Dehydrogenase C5Y82_06015 ENOG4107RUY (E1 component), alpha subunit C5Y82_06020 ENOG4105CPP Dehydrogenase, E1 component C5Y82_06025 ENOG4107QKR Dehydrogenase C5Y82_06035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5Y82_06040 ENOG4105CHR reductase C5Y82_06045 ENOG4107RHR regulatoR C5Y82_06055 ENOG4107R7I amino acid C5Y82_06065 ENOG4105C0H protease C5Y82_06075 ENOG4108ME1 Peptidase M55 D-aminopeptidase C5Y82_06080 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5Y82_06085 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Y82_06090 ENOG4105C3U ABC transporter C5Y82_06100 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C5Y82_06105 ENOG4105DTQ mandelate racemase muconate lactonizing C5Y82_06110 ENOG4107SN7 NLP P60 protein C5Y82_06115 ENOG4108JQ7 (ABC) transporter C5Y82_06120 ENOG4107TUM Amidinotransferase C5Y82_06125 ENOG4108S4H thioesterase Superfamily protein C5Y82_06130 ENOG4105K7K Transcriptional regulator C5Y82_06145 ENOG4108428 Inherit from COG: -acetyltransferase C5Y82_06150 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5Y82_06160 ENOG410839T multidrug resistance protein C5Y82_06165 ENOG41080TC multidrug resistance protein C5Y82_06175 ENOG4105CIY formyltetrahydrofolate deformylase C5Y82_06185 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C5Y82_06210 ENOG4105K56 Transcriptional regulator C5Y82_06215 ENOG4108ZHJ Organic hydroperoxide resistance protein C5Y82_06220 ENOG4107Y2X deaminase C5Y82_06225 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C5Y82_06230 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5Y82_06235 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Y82_06240 ENOG41062D9 Histidine kinase C5Y82_06250 ENOG4106849 propeptide, pepSY amd peptidase M4 C5Y82_06260 ENOG4105CJW magnesium transporter C5Y82_06285 ENOG4105V75 Transcriptional regulator C5Y82_06300 ENOG4105BZU Histidine kinase C5Y82_06305 ENOG4107T5V SNARE associated Golgi C5Y82_06310 ENOG4107TS3 membrane protein, TerC C5Y82_06315 ENOG4108WZW RNA polymerase sigma C5Y82_06325 ENOG410681C small acid-soluble spore protein C5Y82_06335 ENOG4105D0M Protease HtpX homolog C5Y82_06345 ENOG410900G Protein of unknown function (DUF421) C5Y82_06350 ENOG4108TGC Acyltransferase C5Y82_06355 ENOG4105BZU Histidine kinase C5Y82_06360 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C5Y82_06365 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C5Y82_06370 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C5Y82_06380 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate C5Y82_06385 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C5Y82_06390 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C5Y82_06395 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C5Y82_06405 ENOG4105BZU Histidine kinase C5Y82_06410 ENOG41090MY MarR family Transcriptional regulator C5Y82_06415 ENOG4105ER2 Ompa motb domain protein C5Y82_06420 ENOG4105E14 MotA TolQ exbB proton channel C5Y82_06430 ENOG4108K88 Membrane C5Y82_06435 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C5Y82_06440 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C5Y82_06445 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C5Y82_06450 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C5Y82_06470 ENOG4108MK9 spermidine N(1)-acetyltransferase C5Y82_06485 ENOG4105F0V Cell wall hydrolase C5Y82_06505 ENOG4105C59 p-type ATPase C5Y82_06510 ENOG4105DC7 peptidase M24 C5Y82_06520 ENOG4105CID antiterminator C5Y82_06530 ENOG4105KRI phosphocarrier protein (HPr C5Y82_06535 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C5Y82_06545 ENOG4105F6S Spore photoproduct lyase C5Y82_06550 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C5Y82_06555 ENOG4105CHR reductase C5Y82_06560 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C5Y82_06570 ENOG4105K4I Scp-like extracellular C5Y82_06580 ENOG4105BZU Histidine kinase C5Y82_06585 ENOG4105CHM Aminotransferase C5Y82_06595 ENOG41085PJ rdd domain containing protein C5Y82_06605 ENOG4107R88 Chemotaxis protein (CheV) C5Y82_06610 ENOG4105UIN C5Y82_06625 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein C5Y82_06635 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C5Y82_06640 ENOG4105EPM Diguanylate phosphodiesterase C5Y82_06645 ENOG4105WEF catalase C5Y82_06650 ENOG4107IN1 Protein of unknown function (DUF1797) C5Y82_06655 ENOG4108XRC Protein of unknown function (DUF458) C5Y82_06690 ENOG4105NQC Flavodoxin C5Y82_06695 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) C5Y82_06705 ENOG4106AUC UPF0180 protein C5Y82_06710 ENOG4105D8X mechanosensitive ion channel C5Y82_06715 ENOG4105D3R alkyl hydroperoxide reductase C5Y82_06720 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5Y82_06735 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C5Y82_06740 ENOG4105D06 uba thif-type nad fad binding protein C5Y82_06750 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C5Y82_06755 ENOG4108ZAF Molybdopterin C5Y82_06760 ENOG41067WU Molybdopterin converting factor (Subunit 1) C5Y82_06775 ENOG4107X8C Efflux transporter RND family MFP subunit C5Y82_06780 ENOG4105C19 ABC transporter C5Y82_06785 ENOG4107RBB ABC transporter, permease C5Y82_06790 ENOG4105E98 transcriptional regulator DeoR family C5Y82_06795 ENOG4105DE4 1-phosphofructokinase C5Y82_06800 ENOG4105DM4 PTS System C5Y82_06805 ENOG4105C3F Signal peptidase i C5Y82_06815 ENOG4105C5H ABC transporter C5Y82_06840 ENOG4105BZU Histidine kinase C5Y82_06850 ENOG4107ZYR domain protein C5Y82_06855 ENOG4105CPN adenine deaminase C5Y82_06860 ENOG4105CN5 Metallo-Beta-Lactamase C5Y82_06870 ENOG4108X4Q Hydrolase C5Y82_06890 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C5Y82_06910 ENOG4105CPP Dehydrogenase, E1 component C5Y82_06915 ENOG4105C7S Dehydrogenase C5Y82_06920 ENOG4107QN2 dihydrolipoyl dehydrogenase C5Y82_06940 ENOG4105CXN decarboxylase C5Y82_06950 ENOG4108WQ8 UPF0637 protein C5Y82_06960 ENOG4105ECY inositol monophosphatase C5Y82_06975 ENOG4105CI3 gtp-binding protein typa C5Y82_06980 ENOG4105QA2 C5Y82_06995 ENOG4108IAB Phoh family C5Y82_07005 ENOG4105CSV Glutaminase C5Y82_07015 ENOG4105CNI cell division protein FtsW C5Y82_07020 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C5Y82_07025 ENOG4105CVP deoxyribo-dipyrimidine photolyase C5Y82_07035 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C5Y82_07045 ENOG4105BZ9 Cytochrome C oxidase, subunit I C5Y82_07050 ENOG4105CCU oxidase (Subunit III) C5Y82_07055 ENOG41064X9 cytochrome C oxidase subunit IV C5Y82_07070 ENOG41080XQ Signal transduction protein with cbs domains C5Y82_07075 ENOG4106UY4 Inherit from COG: Scp-like extracellular C5Y82_07100 ENOG4105WUC UPF0298 protein C5Y82_07105 ENOG4106H78 methyltransferase C5Y82_07110 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C5Y82_07115 ENOG4105H20 Sporulation integral membrane protein YlbJ C5Y82_07120 ENOG4105D78 K07001 NTE family protein C5Y82_07125 ENOG41063PX domain protein C5Y82_07130 ENOG4105CDE UPF0348 protein C5Y82_07135 ENOG4105KNH Nucleic acid-binding protein C5Y82_07140 ENOG41067VY 50S ribosomal protein L32 C5Y82_07165 ENOG4108V6E Cell division protein mraZ C5Y82_07170 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C5Y82_07180 ENOG4105CJN penicillin-binding protein C5Y82_07190 ENOG4105CJN penicillin-binding protein C5Y82_07195 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C5Y82_07200 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C5Y82_07205 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C5Y82_07210 ENOG4105CNI cell division protein FtsW C5Y82_07215 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C5Y82_07220 ENOG4105D4A Cell wall formation (By similarity) C5Y82_07225 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C5Y82_07230 ENOG4108R2U division initiation protein C5Y82_07240 ENOG4105K67 small basic protein C5Y82_07245 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C5Y82_07250 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C5Y82_07260 ENOG4105FFI sigma-e processing peptidase spoiiga C5Y82_07265 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Y82_07275 ENOG4105DKT Transcriptional regulator C5Y82_07290 ENOG410787A Pts system, glucitol sorbitol-specific C5Y82_07295 ENOG4105DZY Pts system, glucitol sorbitol-specific C5Y82_07300 ENOG4105VI0 Pts system, glucitol sorbitol-specific C5Y82_07305 ENOG4105DKW ABC transporter C5Y82_07310 ENOG4105WR5 sporulation protein, YlmC YmxH family C5Y82_07315 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C5Y82_07320 ENOG4105DFA alanine racemase domain protein C5Y82_07325 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C5Y82_07330 ENOG41067XK integral membrane protein C5Y82_07335 ENOG4105DBK s4 domain protein C5Y82_07345 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C5Y82_07355 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C5Y82_07360 ENOG4105C34 Pseudouridine synthase C5Y82_07365 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C5Y82_07375 ENOG4105CXT aspartate transcarbamylase C5Y82_07380 ENOG4105CD3 dihydroorotase C5Y82_07385 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C5Y82_07390 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C5Y82_07395 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C5Y82_07400 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C5Y82_07405 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C5Y82_07410 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C5Y82_07420 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C5Y82_07430 ENOG4107RIQ Sulfate adenylate transferase C5Y82_07435 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) C5Y82_07440 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C5Y82_07445 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C5Y82_07450 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C5Y82_07455 ENOG4105F23 Fibronectin-binding protein C5Y82_07465 ENOG4105DSJ YicC domain protein C5Y82_07470 ENOG4105KC4 UPF0296 protein C5Y82_07475 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C5Y82_07485 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C5Y82_07490 ENOG4105C25 Primosomal protein n' C5Y82_07495 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C5Y82_07500 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C5Y82_07505 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C5Y82_07510 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C5Y82_07515 ENOG4108ZF3 Phosphatase C5Y82_07520 ENOG4105D9P serine threonine protein kinase C5Y82_07525 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C5Y82_07530 ENOG4105DJV ribulose-phosphate 3-epimerase C5Y82_07535 ENOG4105FJ0 thiamine C5Y82_07545 ENOG4105VB9 50S ribosomal protein l28 C5Y82_07550 ENOG4108ZAA Alkaline-shock protein C5Y82_07555 ENOG4105DP4 dak2 domain fusion protein ylov C5Y82_07565 ENOG4105EJQ L-serine dehydratase C5Y82_07570 ENOG4105CB5 ATP-dependent DNA helicase recG C5Y82_07575 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C5Y82_07580 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) C5Y82_07585 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C5Y82_07590 ENOG4105CHR reductase C5Y82_07595 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) C5Y82_07600 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C5Y82_07605 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C5Y82_07610 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C5Y82_07615 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C5Y82_07625 ENOG4105K5M 30s ribosomal protein S16 C5Y82_07630 ENOG4108BW8 UPF0109 protein C5Y82_07640 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C5Y82_07645 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C5Y82_07650 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C5Y82_07655 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C5Y82_07660 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5Y82_07670 ENOG4105VM1 flagellar C5Y82_07675 ENOG4105CMV Succinyl-CoA synthetase subunit beta C5Y82_07680 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C5Y82_07685 ENOG4105C79 DNA protecting protein DprA C5Y82_07690 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C5Y82_07695 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C5Y82_07700 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5Y82_07705 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C5Y82_07710 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C5Y82_07720 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C5Y82_07725 ENOG4108ZC9 flagellar basal-body rod protein flgc C5Y82_07730 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C5Y82_07735 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C5Y82_07740 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C5Y82_07755 ENOG4106YF4 Flagellar biosynthesis chaperone C5Y82_07765 ENOG410696Y Flagellar hook-length control protein C5Y82_07770 ENOG410822I Flagellar hook capping protein C5Y82_07775 ENOG4108JQA flagellar C5Y82_07780 ENOG41068WV flagellar FlbD family protein C5Y82_07790 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C5Y82_07795 ENOG4105DD5 Flagellar motor switch protein C5Y82_07800 ENOG4107YTP response regulator receiver protein C5Y82_07810 ENOG4105CN7 Flagellar biosynthetic protein FliP C5Y82_07815 ENOG4105VS8 Flagellar biosynthetic protein fliq C5Y82_07820 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C5Y82_07825 ENOG4105D00 flagellar biosynthetic protein flhB C5Y82_07830 ENOG4105D7B Flagellar biosynthesis protein flha C5Y82_07835 ENOG4105FZW flagellar biosynthesis regulator FlhF C5Y82_07845 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C5Y82_07850 ENOG4105CBS Chea signal transduction histidine kinase C5Y82_07855 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C5Y82_07865 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) C5Y82_07870 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Y82_07880 ENOG4105CE9 30S ribosomal protein S2 C5Y82_07885 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C5Y82_07895 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C5Y82_07900 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C5Y82_07905 ENOG4105KNE Phosphatidate cytidylyltransferase C5Y82_07910 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C5Y82_07915 ENOG4105DZP Membrane-associated zinc metalloprotease C5Y82_07920 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C5Y82_07925 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C5Y82_07935 ENOG4105CYP glycoside hydrolase, family C5Y82_07940 ENOG4105WJF C5Y82_07950 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C5Y82_07955 ENOG4105CHV Transcription elongation factor NusA C5Y82_07960 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C5Y82_07965 ENOG4105VHM ribosomal protein C5Y82_07970 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C5Y82_07975 ENOG4105W7A Protein of unknown function (DUF503) C5Y82_07980 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C5Y82_07985 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C5Y82_07990 ENOG4105DTN riboflavin biosynthesis protein ribF C5Y82_07995 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C5Y82_08000 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C5Y82_08010 ENOG4105C1V Peptidase, M16 C5Y82_08025 ENOG4105E35 Dipicolinate synthase subunit A C5Y82_08030 ENOG4108S0H Dipicolinic acid synthetase, b subunit C5Y82_08035 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C5Y82_08045 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C5Y82_08055 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C5Y82_08065 ENOG4105CNU cell division protein FtsK C5Y82_08070 ENOG4105FDP GntR family transcriptional regulator C5Y82_08080 ENOG4105EYF MMPL domain protein C5Y82_08100 ENOG4105EYF MMPL domain protein C5Y82_08105 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C5Y82_08110 ENOG4105XZV Protein of unknown function (DUF3243) C5Y82_08125 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C5Y82_08130 ENOG4105CEV competence damage-inducible protein C5Y82_08135 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) C5Y82_08140 ENOG4108A04 Beta-lactamase C5Y82_08145 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C5Y82_08150 ENOG4105D48 metallophosphoesterase C5Y82_08155 ENOG4105MCT stage V sporulation protein S C5Y82_08165 ENOG4105CPQ Dehydrogenase C5Y82_08170 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C5Y82_08175 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C5Y82_08190 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C5Y82_08195 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C5Y82_08215 ENOG4108VJ1 Transcriptional regulator (CarD family C5Y82_08220 ENOG4105K7W phage-related replication protein C5Y82_08230 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C5Y82_08235 ENOG4105K7W phage-related replication protein C5Y82_08240 ENOG4108X3M OsmC Ohr family protein C5Y82_08245 ENOG410814C multidrug resistance protein C5Y82_08270 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C5Y82_08290 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C5Y82_08295 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C5Y82_08300 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C5Y82_08305 ENOG4105U6W MutT NUDIX family protein C5Y82_08315 ENOG4106F1P AAA ATPase, central domain protein C5Y82_08320 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C5Y82_08325 ENOG4105CXI aluminum resistance protein C5Y82_08330 ENOG4105KV4 Transcriptional regulator C5Y82_08335 ENOG4105C5F glutamine synthetase C5Y82_08405 ENOG4105CDU Replicative dna helicase C5Y82_08415 ENOG4105QBX endodeoxyribonuclease RusA C5Y82_08490 ENOG4105IG6 Phage terminase, large subunit C5Y82_08495 ENOG4108MDF Phage Portal Protein C5Y82_08500 ENOG4106CGH Phage Mu protein F like protein C5Y82_08535 ENOG41060SN C5Y82_08550 ENOG4105PQS phage protein C5Y82_08555 ENOG4105FR7 XkdM protein, phage-like element PBSX C5Y82_08560 ENOG4105MTC XkdN-like protein C5Y82_08565 ENOG4108FKH Transglycosylase SLT domain C5Y82_08565 ENOG4108FKH Transglycosylase SLT domain C5Y82_08570 ENOG4108WZM domain protein C5Y82_08575 ENOG4105X7F C5Y82_08585 ENOG4105MFU Protein of unknown function (DUF2634) C5Y82_08590 ENOG41066EA baseplate J family protein C5Y82_08595 ENOG410906S phage-like element pbsx protein xkdt C5Y82_08630 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C5Y82_08765 ENOG4108ZMX Domain of unknown function (DU1801) C5Y82_08785 ENOG410780I phosphoprotein phosphatase activity C5Y82_08795 ENOG4105XPP Protein of unknown function (DUF1275) C5Y82_08800 ENOG4105DQE DNA ligase C5Y82_08805 ENOG4105FDF Could be involved in DNA repair (By similarity) C5Y82_08810 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C5Y82_08820 ENOG4108Z40 Transcriptional regulator C5Y82_08825 ENOG4105ECR NmrA family C5Y82_08830 ENOG4107R5T Cysteine-rich domain C5Y82_08835 ENOG4107QR9 Iron-sulfur cluster binding protein C5Y82_08840 ENOG41080R8 Conserved Protein C5Y82_08865 ENOG41082JN Transcriptional regulator C5Y82_08870 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C5Y82_08875 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases C5Y82_08880 ENOG4105WFK nuclease C5Y82_08885 ENOG4106SCS STAS domain C5Y82_08900 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C5Y82_08910 ENOG4108SVB resolvase C5Y82_08915 ENOG4105VPS UPF0291 protein C5Y82_08920 ENOG4105CV1 Transketolase (EC 2.2.1.1) C5Y82_08930 ENOG4105VXM UPF0154 protein C5Y82_08940 ENOG4107QIV Cytochrome c biogenesis protein C5Y82_08970 ENOG4108I0Z Aconitate hydratase C5Y82_08975 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5Y82_09000 ENOG4105MI2 C5Y82_09005 ENOG4105W8X HesB YadR YfhF-family protein C5Y82_09010 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C5Y82_09015 ENOG4105K4P CoA-binding domain protein C5Y82_09025 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C5Y82_09040 ENOG4106UW1 Major Facilitator superfamily C5Y82_09060 ENOG4105CB2 alcohol dehydrogenase C5Y82_09075 ENOG4105DYS nad(p)h dehydrogenase (quinone) C5Y82_09080 ENOG4105KVH Transcriptional regulator C5Y82_09085 ENOG4105C6T cysteine synthase C5Y82_09090 ENOG4105KME endoribonuclease L-psp C5Y82_09130 ENOG4106H6A C5Y82_09135 ENOG4105N0V mono-oxygenase ydhR C5Y82_09165 ENOG4108Z6Z Transcriptional regulator C5Y82_09170 ENOG4105CS2 ec 3.2.1.21 C5Y82_09175 ENOG4105C5Y PTS System C5Y82_09195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5Y82_09205 ENOG4107SYN Glycosyl hydrolases family 43 C5Y82_09220 ENOG4105I1K ABC transporter C5Y82_09225 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component C5Y82_09240 ENOG4105UP7 3-epimerase C5Y82_09255 ENOG4106ETB IIa component C5Y82_09300 ENOG4105D2N Aldolase C5Y82_09305 ENOG4105DM4 PTS System C5Y82_09310 ENOG4105DM4 PTS System C5Y82_09320 ENOG4105HX0 Transcriptional regulator C5Y82_09325 ENOG4107RZC phospholipase d C5Y82_09345 ENOG4105C26 Dehydrogenase C5Y82_09355 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C5Y82_09365 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C5Y82_09370 ENOG4107QX3 carboxylase C5Y82_09375 ENOG4105E39 Enoyl-CoA hydratase C5Y82_09380 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C5Y82_09385 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C5Y82_09390 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5Y82_09395 ENOG4105CEY Amp-dependent synthetase and ligase C5Y82_09400 ENOG4105C1G acyl-Coa dehydrogenase C5Y82_09405 ENOG4105F32 YngK protein C5Y82_09430 ENOG4105CQB FAD linked oxidase domain protein C5Y82_09435 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C5Y82_09445 ENOG4108B31 Spore germination protein C5Y82_09465 ENOG4107T5V SNARE associated Golgi C5Y82_09470 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C5Y82_09480 ENOG4105DEN Luciferase family C5Y82_09495 ENOG4107QJQ Mate efflux family protein C5Y82_09500 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C5Y82_09505 ENOG4105NBR Pectinesterase C5Y82_09510 ENOG4105H67 Protein of unknown function (DUF421) C5Y82_09515 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C5Y82_09520 ENOG4108IFG nitrite reductase, (NAD(P)H) C5Y82_09525 ENOG4105BZ8 glutamate synthase C5Y82_09530 ENOG4105CBC glutamate synthase C5Y82_09535 ENOG4105C5Q Transcriptional regulator C5Y82_09545 ENOG4105BZ1 (ABC) transporter C5Y82_09555 ENOG4108UYN gCN5-related N-acetyltransferase C5Y82_09565 ENOG4105D9U N-acetyltransferase C5Y82_09570 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) C5Y82_09575 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C5Y82_09590 ENOG4108J2R molybdopterin oxidoreductase C5Y82_09605 ENOG4105CMG Carbohydrate kinase C5Y82_09615 ENOG4105E2R ROK family C5Y82_09625 ENOG4105CT4 transporter C5Y82_09635 ENOG4108Z7R Chaperone CsaA C5Y82_09645 ENOG4105FVX C5Y82_09665 ENOG4108W8B Beta-lactamase domain protein C5Y82_09675 ENOG4105D29 Helix-turn-helix type 11 domain protein C5Y82_09685 ENOG4105KTU Transcriptional regulator, arsr family C5Y82_09690 ENOG4105CUB amino acid C5Y82_09705 ENOG4105CR4 methylisocitrate lyase C5Y82_09710 ENOG4105DXD 2-methylcitrate dehydratase C5Y82_09720 ENOG4108SJC Membrane C5Y82_09730 ENOG41069ER domain protein C5Y82_09735 ENOG4105C9U ATP-dependent DNA helicase RecQ C5Y82_09745 ENOG4105SCY DNAK suppressor C5Y82_09770 ENOG4105C26 Dehydrogenase C5Y82_09775 ENOG4105EWU Squalene--hopene cyclase C5Y82_09780 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C5Y82_09785 ENOG4105C09 Bile acid C5Y82_09790 ENOG4105C7S Dehydrogenase C5Y82_09795 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 C5Y82_09800 ENOG4107T89 von Willebrand factor, type A C5Y82_09805 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C5Y82_09815 ENOG4105K4H Nlp p60 protein C5Y82_09825 ENOG4107QMU Mate efflux family protein C5Y82_09845 ENOG4105FR1 rard protein C5Y82_09875 ENOG4105E1V na solute symporter C5Y82_09880 ENOG4105JQZ Methyltransferase C5Y82_09900 ENOG4108VXD carboxy-peptidase C5Y82_09905 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C5Y82_09910 ENOG4106Z5R C5Y82_09915 ENOG410841Q phosphoesterase PA-phosphatase related protein C5Y82_09930 ENOG4105VSD UPF0346 protein C5Y82_09940 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C5Y82_09945 ENOG4108JUB Transcriptional regulator C5Y82_09975 ENOG4105C5E polysaccharide biosynthesis protein C5Y82_09980 ENOG4105E0X reductase C5Y82_09985 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C5Y82_10010 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) C5Y82_10015 ENOG41090WU lipolytic protein G-D-S-L family C5Y82_10020 ENOG4108KF3 Electron transport protein SCO1 SenC C5Y82_10035 ENOG4105C7B Threonine dehydratase C5Y82_10045 ENOG4108UT2 hemolysin iii C5Y82_10055 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C5Y82_10060 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C5Y82_10075 ENOG4107YX5 Pfam:DUF548 C5Y82_10080 ENOG4108Y6J UPF0403 protein C5Y82_10085 ENOG4105C01 Dihydroxy-acid dehydratase C5Y82_10100 ENOG4108V06 Glutathione peroxidase C5Y82_10105 ENOG4105CKU formyltetrahydrofolate synthetase C5Y82_10110 ENOG4105CVG Homoserine O-transsuccinylase C5Y82_10115 ENOG4108QBV Monogalactosyldiacylglycerol synthase C5Y82_10150 ENOG41081VK Ribonuclease C5Y82_10170 ENOG410890F Dynamin family C5Y82_10185 ENOG41065KQ synthase C5Y82_10190 ENOG4107VMI polysaccharide deacetylase C5Y82_10195 ENOG4105C2W permease C5Y82_10205 ENOG4105CTD carboxy-peptidase C5Y82_10210 ENOG4105DVT helicase C5Y82_10225 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C5Y82_10235 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) C5Y82_10240 ENOG4108UKS UPF0398 protein C5Y82_10250 ENOG4107X2U Inherit from COG: Exonuclease-like protein C5Y82_10255 ENOG4108I5C dEAD DEAH box helicase C5Y82_10260 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5Y82_10300 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) C5Y82_10305 ENOG4105BZ4 penicillin-binding protein C5Y82_10315 ENOG4105CSM endonuclease III C5Y82_10335 ENOG4105YAC C5Y82_10340 ENOG4105DVT helicase C5Y82_10345 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C5Y82_10350 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C5Y82_10355 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C5Y82_10365 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate C5Y82_10370 ENOG4105CPK Glycosyl transferase (Group 1 C5Y82_10375 ENOG4105FJR Lmbe family C5Y82_10380 ENOG4108Z5K methylglyoxal synthase C5Y82_10385 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C5Y82_10390 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C5Y82_10395 ENOG4108JYZ YitT family C5Y82_10415 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C5Y82_10430 ENOG4108SXZ UPF0302 protein C5Y82_10435 ENOG41068YB TPR repeat-containing protein C5Y82_10440 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C5Y82_10450 ENOG4105CIH Imidazole acetol-phosphate transaminase C5Y82_10455 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C5Y82_10460 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C5Y82_10470 ENOG4105DK0 Indole-3-glycerol phosphate synthase C5Y82_10475 ENOG4108I0Q anthranilate phosphoribosyltransferase C5Y82_10485 ENOG4105KHN chorismate mutase C5Y82_10490 ENOG4105D49 3-dehydroquinate synthase C5Y82_10495 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C5Y82_10500 ENOG4105BZU Histidine kinase C5Y82_10505 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C5Y82_10510 ENOG4105EAH synthase C5Y82_10515 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C5Y82_10520 ENOG4105XXQ heptaprenyl diphosphate synthase component I C5Y82_10530 ENOG4105EUJ GTP cyclohydrolase i C5Y82_10535 ENOG4105K70 DNA-binding protein C5Y82_10545 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C5Y82_10560 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C5Y82_10565 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C5Y82_10570 ENOG41065D1 C5Y82_10575 ENOG4105S2F C5Y82_10595 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C5Y82_10600 ENOG4105CAT Cytidine monophosphate kinase C5Y82_10615 ENOG4105MSI germination protein ypeb C5Y82_10625 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) C5Y82_10630 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C5Y82_10645 ENOG4107RGJ metallophosphoesterase C5Y82_10660 ENOG4105I7S Abortive infection protein C5Y82_10665 ENOG4105C9U ATP-dependent DNA helicase RecQ C5Y82_10670 ENOG4105T7X C5Y82_10680 ENOG4108SAX Membrane C5Y82_10685 ENOG4108JQ1 Dehydrogenase C5Y82_10690 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C5Y82_10705 ENOG4105BZU Histidine kinase C5Y82_10710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Y82_10715 ENOG4105CRE cytochrome C C5Y82_10720 ENOG4107TWT Cytochrome c biogenesis protein C5Y82_10730 ENOG4105FE9 pseudouridine synthase C5Y82_10740 ENOG4108JIC nucleoside recognition domain protein C5Y82_10745 ENOG4105DZ1 carboxypeptidase C5Y82_10755 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C5Y82_10760 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C5Y82_10780 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C5Y82_10785 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5Y82_10790 ENOG4108R6K riboflavin synthase, subunit alpha C5Y82_10815 ENOG4105EQ0 Major Facilitator superfamily C5Y82_10820 ENOG4107ZE5 PPIases accelerate the folding of proteins C5Y82_10825 ENOG4105PTM secreted protein C5Y82_10835 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C5Y82_10845 ENOG4105G6R Stage v sporulation protein ae C5Y82_10855 ENOG4105CZ3 stage V sporulation protein ad C5Y82_10860 ENOG41090VF Stage v sporulation protein ac C5Y82_10875 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Y82_10880 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C5Y82_10885 ENOG41082AN stage II sporulation protein C5Y82_10890 ENOG4105DZ1 carboxypeptidase C5Y82_10895 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C5Y82_10900 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C5Y82_10905 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5Y82_10915 ENOG4105I3K Ferric uptake regulator, Fur family C5Y82_10920 ENOG4105MZ9 stage II sporulation protein m C5Y82_10935 ENOG4107YB6 acetyltransferase, (GNAT) family C5Y82_10945 ENOG4108YZ4 nudix hydrolase C5Y82_10950 ENOG4105CPC Aldo Keto reductase C5Y82_10980 ENOG4106HZJ C5Y82_10985 ENOG4105RHY Pfam:UPF0157 C5Y82_10990 ENOG4108XET gCN5-related N-acetyltransferase C5Y82_11000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5Y82_11010 ENOG4105E5W Transporter C5Y82_11025 ENOG4108IXY short-chain dehydrogenase reductase C5Y82_11030 ENOG41069FQ Metallo-beta-lactamase superfamily C5Y82_11035 ENOG4105II7 pyrroline-5-carboxylate reductase C5Y82_11050 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C5Y82_11060 ENOG4105XT2 Transcriptional regulator C5Y82_11065 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C5Y82_11070 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C5Y82_11075 ENOG4108TZY GntR Family Transcriptional Regulator C5Y82_11080 ENOG4105CS2 ec 3.2.1.21 C5Y82_11085 ENOG4105CK1 PTS System C5Y82_11090 ENOG4105VCP PTS System C5Y82_11095 ENOG4105VZJ PTS System C5Y82_11100 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C5Y82_11105 ENOG4105CSC Glucose uptake protein C5Y82_11110 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C5Y82_11115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C5Y82_11130 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C5Y82_11145 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C5Y82_11150 ENOG4108HNZ carboxyl transferase C5Y82_11155 ENOG4108ZVT methylmalonyl-coA epimerase C5Y82_11160 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C5Y82_11165 ENOG4108QEG Membrane C5Y82_11170 ENOG4105CDA abc transporter atp-binding protein C5Y82_11175 ENOG4105E5Q amino acid AbC transporter C5Y82_11180 ENOG4108HW3 (ABC) transporter C5Y82_11185 ENOG4108Y6J UPF0403 protein C5Y82_11190 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C5Y82_11200 ENOG4105C7S Dehydrogenase C5Y82_11205 ENOG4105CPP Dehydrogenase, E1 component C5Y82_11220 ENOG4105CKM Branched-chain carboxylic acid kinase C5Y82_11225 ENOG4107RDP Dehydrogenase C5Y82_11235 ENOG4108JUB Transcriptional regulator C5Y82_11240 ENOG4106CCJ Protein of unknown function (DUF2627) C5Y82_11245 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C5Y82_11260 ENOG4107QQR Sporulation C5Y82_11265 ENOG4105S1Z Stage IV sporulation protein B C5Y82_11270 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C5Y82_11275 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C5Y82_11280 ENOG4105DX0 Hemolysin A C5Y82_11285 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C5Y82_11290 ENOG4105CTB Polyprenyl synthetase C5Y82_11295 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5Y82_11300 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C5Y82_11305 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C5Y82_11310 ENOG4105M7K Involved in the transcription termination process (By similarity) C5Y82_11315 ENOG4108ZSR alkaline shock protein C5Y82_11320 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C5Y82_11340 ENOG410644B Stage III sporulation protein af C5Y82_11350 ENOG4105KQ4 Stage iii sporulation protein ad C5Y82_11355 ENOG4108CQH stage III sporulation protein AC C5Y82_11360 ENOG4105KR5 Stage iii sporulation protein C5Y82_11365 ENOG4105CD2 stage iii sporulation protein aa C5Y82_11375 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C5Y82_11380 ENOG4105DC7 peptidase M24 C5Y82_11385 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C5Y82_11395 ENOG4105CBJ Metal-dependent enzyme C5Y82_11410 ENOG4105KST dependent repressor C5Y82_11415 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C5Y82_11420 ENOG4105WZW rhodanese family C5Y82_11425 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C5Y82_11430 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C5Y82_11435 ENOG4105C0D helicase C5Y82_11450 ENOG4108IMY Transcriptional regulator C5Y82_11460 ENOG4105VFR signal peptidase C5Y82_11500 ENOG4106855 Competence protein C5Y82_11545 ENOG4105C5X domain protein C5Y82_11575 ENOG4105E0M Sulfatase C5Y82_11590 ENOG4107ZXI Rhomboid family C5Y82_11595 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C5Y82_11600 ENOG4105WDJ 50S ribosomal protein L33 C5Y82_11610 ENOG41068DG YceG-like family C5Y82_11615 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C5Y82_11620 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C5Y82_11625 ENOG4105E2Z phosphate ABC transporter (Permease C5Y82_11630 ENOG4105C8U phosphate abc transporter C5Y82_11635 ENOG4105CVA phosphate C5Y82_11640 ENOG4107RF6 penicillin-binding protein C5Y82_11650 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C5Y82_11655 ENOG4105SXS Protein of unknown function (DUF456) C5Y82_11665 ENOG4105D9U N-acetyltransferase C5Y82_11675 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C5Y82_11680 ENOG41063Y9 C5Y82_11685 ENOG4108U5J '-nucleotidase C5Y82_11690 ENOG41066F8 ROK family C5Y82_11700 ENOG4105N80 Ferric uptake regulator, Fur family C5Y82_11705 ENOG4105FAV ABC, transporter C5Y82_11710 ENOG4105FDK ABC transporter C5Y82_11715 ENOG4108JYZ YitT family C5Y82_11720 ENOG41069ZM Protein of unknown function (DUF2624) C5Y82_11725 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C5Y82_11740 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C5Y82_11745 ENOG4105EGD dinuclear metal center protein, YbgI family C5Y82_11760 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Y82_11765 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C5Y82_11770 ENOG4108UPT UPF0178 protein C5Y82_11775 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C5Y82_11785 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C5Y82_11790 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C5Y82_11795 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) C5Y82_11805 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C5Y82_11810 ENOG4105KG3 cytidine deaminase C5Y82_11815 ENOG4107YR5 Diacylglycerol kinase C5Y82_11820 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C5Y82_11825 ENOG4105CTJ Metal Dependent Phosphohydrolase C5Y82_11830 ENOG4105C9A Phoh family C5Y82_11835 ENOG4105EI1 sporulation protein yqfd C5Y82_11840 ENOG41068P3 sporulation protein YqfC C5Y82_11850 ENOG4105DI5 UPF0365 protein C5Y82_11855 ENOG4105F7J membrane-bound serine protease C5Y82_11860 ENOG4105KTH gatB Yqey C5Y82_11875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C5Y82_11880 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C5Y82_11885 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C5Y82_11890 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) C5Y82_11900 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C5Y82_11905 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C5Y82_11910 ENOG4105CSA Coproporphyrinogen iii oxidase C5Y82_11915 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C5Y82_11925 ENOG4108ZRV stage ii sporulation protein p C5Y82_11940 ENOG4105TQK DNA polymerase iii, delta' subunit C5Y82_11950 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C5Y82_11955 ENOG4108UK2 deaminase C5Y82_11960 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein C5Y82_11970 ENOG4108D32 Methyltransferase C5Y82_11980 ENOG4108WF2 Metal Dependent Phosphohydrolase C5Y82_11985 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C5Y82_11990 ENOG410812S Rna-binding protein C5Y82_11995 ENOG4105E2X shikimate dehydrogenase C5Y82_12000 ENOG4105CQW ribosome biogenesis GTPase YqeH C5Y82_12005 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C5Y82_12030 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Y82_12055 ENOG4108ZJ4 polysaccharide deacetylase C5Y82_12085 ENOG4107QNK )-transporter C5Y82_12090 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) C5Y82_12105 ENOG4105CMD Transcriptional regulator, GntR family C5Y82_12115 ENOG41080HJ 6-phospho 3-hexuloisomerase C5Y82_12120 ENOG4108VA3 3-hexulose-6-phosphate synthase C5Y82_12125 ENOG4105KVH Transcriptional regulator C5Y82_12145 ENOG4105CNA YD repeat protein C5Y82_12150 ENOG4108HWY Beta-lactamase C5Y82_12155 ENOG4105FDT acyl-CoA dehydrogenase C5Y82_12175 ENOG4105E5Q amino acid AbC transporter C5Y82_12180 ENOG4105WEF catalase C5Y82_12195 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C5Y82_12200 ENOG4105C0A alcohol dehydrogenase C5Y82_12210 ENOG4107V2S Transcriptional regulator C5Y82_12215 ENOG4105BZ1 (ABC) transporter C5Y82_12220 ENOG4108UYN gCN5-related N-acetyltransferase C5Y82_12225 ENOG4105E2A Dehydrogenase C5Y82_12250 ENOG4105C28 cystathionine C5Y82_12260 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C5Y82_12265 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C5Y82_12280 ENOG4107XRG penicillin-binding protein C5Y82_12285 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C5Y82_12290 ENOG4107S03 uridine kinase C5Y82_12295 ENOG4105CFP Peptidase U32 C5Y82_12300 ENOG4105XYU peptidase (U32 family) C5Y82_12305 ENOG4108VQJ O-methyltransferase C5Y82_12310 ENOG4105HHA aminodeoxychorismate lyase C5Y82_12320 ENOG4107F3J Amp-dependent synthetase and ligase C5Y82_12325 ENOG4107ZYJ bioY protein C5Y82_12330 ENOG4105VPH UPF0473 protein C5Y82_12335 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C5Y82_12340 ENOG4105VBH UPF0297 protein C5Y82_12350 ENOG4105C02 permease C5Y82_12355 ENOG4105CDA abc transporter atp-binding protein C5Y82_12360 ENOG4105CT1 (ABC) transporter C5Y82_12365 ENOG4105EAD ABC transporter C5Y82_12370 ENOG4105DRP amino acid AbC transporter C5Y82_12385 ENOG41060CR C5Y82_12395 ENOG4105C7H Helicase, RecD TraA family C5Y82_12405 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C5Y82_12410 ENOG4105C3J Cysteine desulfurase C5Y82_12420 ENOG4105D1H recombination factor protein RarA C5Y82_12430 ENOG4105CUZ uba thif-type nad fad binding protein C5Y82_12440 ENOG4105C9M aspartyl-trna synthetase C5Y82_12445 ENOG4105CUT histidyl-tRNA synthetase C5Y82_12450 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5Y82_12455 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) C5Y82_12460 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C5Y82_12465 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C5Y82_12470 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C5Y82_12475 ENOG41067VP Protein of unknown function (DUF1049) C5Y82_12485 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C5Y82_12495 ENOG4105CKP Polysaccharide Biosynthesis Protein C5Y82_12500 ENOG4108QG2 Membrane C5Y82_12505 ENOG4105NAP C5Y82_12510 ENOG4105VIE preprotein translocase, subunit YajC C5Y82_12515 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C5Y82_12520 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C5Y82_12525 ENOG41061AI Protein of unknown function (DUF2905) C5Y82_12530 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C5Y82_12535 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C5Y82_12555 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C5Y82_12570 ENOG4106678 morphogenetic protein associated with SpoVID C5Y82_12575 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C5Y82_12580 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C5Y82_12585 ENOG4108IYU L-aspartate oxidase C5Y82_12600 ENOG4105CQC Prephenate dehydratase C5Y82_12610 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C5Y82_12620 ENOG4105K46 50S ribosomal protein l27 C5Y82_12625 ENOG4105X36 (ribosomal) protein C5Y82_12630 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C5Y82_12645 ENOG4107QMS site-determining protein C5Y82_12650 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C5Y82_12655 ENOG4105YHC Rod shape-determining protein MreD C5Y82_12660 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C5Y82_12665 ENOG4105DFF Rod shape-determining protein mreb C5Y82_12670 ENOG4105W5Q DNA repair protein (RadC C5Y82_12675 ENOG4108Z03 MAF-like protein C5Y82_12685 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) C5Y82_12690 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C5Y82_12695 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C5Y82_12705 ENOG4106AR7 Spore coat protein C5Y82_12710 ENOG41068KH stage VI sporulation protein D C5Y82_12715 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C5Y82_12720 ENOG4105D52 delta-aminolevulinic acid dehydratase C5Y82_12730 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C5Y82_12740 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C5Y82_12750 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C5Y82_12755 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C5Y82_12760 ENOG4108IUQ atp-dependent protease C5Y82_12765 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C5Y82_12770 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C5Y82_12780 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5Y82_12785 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C5Y82_12790 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C5Y82_12795 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C5Y82_12800 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C5Y82_12805 ENOG4108ZP8 Acetolactate synthase small subunit C5Y82_12810 ENOG4105C7K acetolactate synthase C5Y82_12815 ENOG4105CM2 brancheD-chain amino acid aminotransferase C5Y82_12820 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C5Y82_12830 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C5Y82_12840 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C5Y82_12845 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C5Y82_12855 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C5Y82_12885 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C5Y82_12895 ENOG4105M59 Phosphodiesterase, mj0936 family C5Y82_12900 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C5Y82_12905 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C5Y82_12910 ENOG4108XJQ germination protein C5Y82_12915 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C5Y82_12920 ENOG41067TZ transcriptional regulator, MarR family C5Y82_12925 ENOG4105PFC Transcriptional regulator C5Y82_12935 ENOG4108KAM Transcriptional regulator C5Y82_12940 ENOG4105C7F AcnD-accessory protein PrpF C5Y82_12945 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C5Y82_12955 ENOG4105E33 succinate dehydrogenase C5Y82_12965 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C5Y82_12975 ENOG4105CFH Aspartokinase C5Y82_12985 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C5Y82_12990 ENOG4105K63 Thioredoxin C5Y82_12995 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C5Y82_13000 ENOG4105C10 Electron transfer flavoprotein C5Y82_13005 ENOG4105BZJ Electron transfer flavoprotein C5Y82_13010 ENOG41060WC Enoyl-CoA hydratase C5Y82_13015 ENOG4107Z3H Transcriptional regulator, TetR family C5Y82_13020 ENOG4105CEY Amp-dependent synthetase and ligase C5Y82_13035 ENOG4105C98 muts2 protein C5Y82_13040 ENOG4105DCG PHP domain protein C5Y82_13050 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) C5Y82_13055 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C5Y82_13060 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C5Y82_13065 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C5Y82_13070 ENOG4108RWN rrna methyltransferase C5Y82_13075 ENOG41067MF small acid-soluble spore protein C5Y82_13085 ENOG4105CN9 Peptidase m42 family protein C5Y82_13095 ENOG410696E Membrane C5Y82_13100 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C5Y82_13105 ENOG4105VJV 50s ribosomal protein L35 C5Y82_13110 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C5Y82_13115 ENOG41067MG lrgb family C5Y82_13125 ENOG4105DY9 regulatoR C5Y82_13130 ENOG4108HRK Histidine kinase C5Y82_13135 ENOG4105U0R haloacid dehalogenase-like hydrolase C5Y82_13140 ENOG4107SDU Methyl-accepting chemotaxis C5Y82_13145 ENOG4105C22 threonyL-tRNA synthetase C5Y82_13150 ENOG4108TDW sporulation protein YtxC C5Y82_13170 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C5Y82_13180 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C5Y82_13185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C5Y82_13190 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C5Y82_13200 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C5Y82_13205 ENOG4105C2M dna polymerase I C5Y82_13210 ENOG4105BZU Histidine kinase C5Y82_13215 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5Y82_13220 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C5Y82_13225 ENOG4108HMX isocitrate dehydrogenase (NADP) C5Y82_13230 ENOG4105BZN citrate synthase C5Y82_13235 ENOG4107CWS Protein of unknown function (DUF441) C5Y82_13240 ENOG4108REF Sporulation integral membrane protein ytvi C5Y82_13245 ENOG4105FS0 cytoplasmic membrane protein C5Y82_13250 ENOG4105CA9 Pyruvate kinase C5Y82_13255 ENOG4105CTQ phosphohexokinase C5Y82_13265 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) C5Y82_13270 ENOG4105C6K Malic enzyme C5Y82_13275 ENOG4105C0B DNA polymerase III (alpha subunit) C5Y82_13280 ENOG4105VV2 C5Y82_13290 ENOG4106EVM C5Y82_13295 ENOG4105SFS phosphoesterase RecJ domain protein C5Y82_13310 ENOG4105E8R UPF0173 metal-dependent hydrolase C5Y82_13325 ENOG4105CH7 arginosuccinase C5Y82_13330 ENOG4105CDH Citrulline--aspartate ligase C5Y82_13335 ENOG4105EPU Molybdenum cofactor synthesis domain protein C5Y82_13340 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C5Y82_13350 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C5Y82_13355 ENOG4105KBJ sporulation protein ytfj C5Y82_13365 ENOG4105VK3 rdd domain containing protein C5Y82_13370 ENOG4105D07 Signal peptide peptidase, SppA C5Y82_13375 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C5Y82_13380 ENOG4105C1J atp-dependent rna helicase C5Y82_13385 ENOG4105ECK Fatty Acid Desaturase C5Y82_13390 ENOG4108ZGX Histidine kinase C5Y82_13395 ENOG4108S01 response regulator C5Y82_13400 ENOG4108V5C ABC transporter C5Y82_13410 ENOG4105EWM Histidine kinase C5Y82_13415 ENOG4105C19 ABC transporter C5Y82_13425 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) C5Y82_13430 ENOG4108X0B nad(p)h dehydrogenase (quinone) C5Y82_13445 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C5Y82_13450 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C5Y82_13460 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) C5Y82_13490 ENOG4105U5Y Transcriptional regulator C5Y82_13500 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C5Y82_13520 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C5Y82_13525 ENOG4105KAC Antibiotic biosynthesis monooxygenase C5Y82_13530 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C5Y82_13540 ENOG4105F1V Acetoin utilization protein C5Y82_13545 ENOG4105W87 Cbs domain C5Y82_13550 ENOG4105DGU Histone deacetylase C5Y82_13555 ENOG4105ETE Transcriptional regulator (LacI family C5Y82_13560 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C5Y82_13580 ENOG4105DFU Cell wall formation (By similarity) C5Y82_13590 ENOG4108VDD TRNA binding domain protein C5Y82_13595 ENOG4108NKM UPF0354 protein C5Y82_13610 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C5Y82_13630 ENOG4105C6K Malic enzyme C5Y82_13635 ENOG4105C8F Beta-lactamase domain protein C5Y82_13640 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C5Y82_13650 ENOG4108V15 phosphotransferase enzyme family C5Y82_13665 ENOG4107F58 2'-5' rna ligase C5Y82_13670 ENOG4105C6T cysteine synthase C5Y82_13675 ENOG4107UIE peptidase C5Y82_13680 ENOG4107QSE Dipeptidase C5Y82_13685 ENOG4105C7N Xanthine uracil vitamin C permease C5Y82_13690 ENOG4105YW5 deoR family transcriptional regulator C5Y82_13705 ENOG4105CBX hi0933 family C5Y82_13715 ENOG4105C94 Transporter C5Y82_13725 ENOG4106611 bacteriocin immunity C5Y82_13735 ENOG41085GJ domain protein C5Y82_13740 ENOG4105MU9 integral membrane protein C5Y82_13745 ENOG4105DDC Oxidoreductase domain protein C5Y82_13755 ENOG4105F5H Glycosyl Hydrolase Family 88 C5Y82_13765 ENOG41075H3 AraC family transcriptional regulator C5Y82_13770 ENOG4105KVH Transcriptional regulator C5Y82_13775 ENOG4105F27 Major Facilitator C5Y82_13780 ENOG4105CV8 reductase C5Y82_13790 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C5Y82_13800 ENOG4105NTD Inherit from COG: Hydrolase C5Y82_13805 ENOG4105C8T Leucyl-tRNA synthetase C5Y82_13815 ENOG4105BZU Histidine kinase C5Y82_13820 ENOG4106UBQ C5Y82_13825 ENOG4107R34 abc transporter permease protein C5Y82_13830 ENOG4105C19 ABC transporter C5Y82_13840 ENOG4105DVE abc transporter atp-binding protein C5Y82_13845 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C5Y82_13860 ENOG4105N5T Radical SAM Protein C5Y82_13875 ENOG4105E8V Alpha Beta Hydrolase Fold protein C5Y82_13880 ENOG4108Z0R Transferase C5Y82_13885 ENOG4105CAQ asparagine synthetase C5Y82_13890 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C5Y82_13910 ENOG4105EWK phytoene C5Y82_13930 ENOG4105D2X ABC transporter substrate-binding protein C5Y82_13940 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C5Y82_13950 ENOG4106FN3 tellurium resistance protein C5Y82_13975 ENOG4108RMU ferritin dps family protein C5Y82_13990 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C5Y82_13995 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) C5Y82_14000 ENOG4108V2W Carbonate dehydratase C5Y82_14005 ENOG4105DSE periplasmic solute binding protein C5Y82_14010 ENOG4105NRA 50s ribosomal protein l31 type b C5Y82_14040 ENOG4105DTQ mandelate racemase muconate lactonizing C5Y82_14050 ENOG4108IPT Naphthoate synthase C5Y82_14055 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C5Y82_14060 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C5Y82_14065 ENOG4105E4F Isochorismate synthase C5Y82_14070 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C5Y82_14080 ENOG4108606 TspO/MBR family C5Y82_14205 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C5Y82_14215 ENOG4105VRR gCN5-related N-acetyltransferase C5Y82_14225 ENOG4105CNI cell division protein FtsW C5Y82_14230 ENOG4105CNI cell division protein FtsW C5Y82_14235 ENOG4105DZ6 Band 7 protein C5Y82_14245 ENOG4106DF1 C5Y82_14250 ENOG4108JB8 alcohol dehydrogenase C5Y82_14255 ENOG4105C26 Dehydrogenase C5Y82_14260 ENOG4105TRT Transcriptional regulator C5Y82_14270 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C5Y82_14335 ENOG4108TGC Acyltransferase C5Y82_14370 ENOG410906S phage-like element pbsx protein xkdt C5Y82_14375 ENOG41066EA baseplate J family protein C5Y82_14380 ENOG4105MFU Protein of unknown function (DUF2634) C5Y82_14390 ENOG4105X7F C5Y82_14395 ENOG4108WZM domain protein C5Y82_14400 ENOG4108FKH Transglycosylase SLT domain C5Y82_14400 ENOG4108FKH Transglycosylase SLT domain C5Y82_14410 ENOG4105MTC XkdN-like protein C5Y82_14420 ENOG4105FR7 XkdM protein, phage-like element PBSX C5Y82_14425 ENOG4105PQS phage protein C5Y82_14440 ENOG41060SN C5Y82_14465 ENOG4108MDF Phage Portal Protein C5Y82_14470 ENOG4105IG6 Phage terminase, large subunit C5Y82_14490 ENOG4105QBX endodeoxyribonuclease RusA C5Y82_14515 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C5Y82_14530 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C5Y82_14545 ENOG4105EE0 oxidoreductase C5Y82_14550 ENOG4108Z0Z intracellular protease Pfpi family C5Y82_14555 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_14560 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_14565 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_14570 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_14585 ENOG4105EA8 2-Nitropropane dioxygenase C5Y82_14590 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C5Y82_14595 ENOG4105C37 (CBS) domain C5Y82_14610 ENOG4107PBV potassium channel C5Y82_14625 ENOG4107QYV phosphohexose isomerase C5Y82_14635 ENOG4107QW4 alcohol dehydrogenase C5Y82_14640 ENOG4105WG9 Conserved Protein C5Y82_14650 ENOG4105CHM Aminotransferase C5Y82_14655 ENOG4108ZB6 transcriptional regulator AsnC family C5Y82_14660 ENOG4108MUZ hydrolase C5Y82_14670 ENOG4105C87 Aminotransferase class I and II C5Y82_14675 ENOG4108HGU Histidine kinase C5Y82_14685 ENOG4105Y38 Kinase-associated protein B C5Y82_14700 ENOG4105BZ4 penicillin-binding protein C5Y82_14705 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C5Y82_14720 ENOG4108MRH transcriptional regulatory protein C5Y82_14725 ENOG4105DIH basic membrane C5Y82_14730 ENOG4108JQ9 ABC transporter C5Y82_14735 ENOG4105UIB (ABC) transporter C5Y82_14755 ENOG4105D65 subunit l C5Y82_14760 ENOG4105HC0 Na H antiporter C5Y82_14765 ENOG4108ZE9 Monovalent cation H antiporter subunit C C5Y82_14770 ENOG4108JPZ Monovalent cation H antiporter subunit D C5Y82_14775 ENOG4105SC1 monovalent cation H antiporter subunit E C5Y82_14785 ENOG4105KJM monovalent cation h antiporter subunit g C5Y82_14790 ENOG4105KA0 thioesterase Superfamily protein C5Y82_14800 ENOG4105BZU Histidine kinase C5Y82_14825 ENOG4105D58 Diguanylate phosphodiesterase C5Y82_14830 ENOG4105DAP Nicotinate phosphoribosyltransferase C5Y82_14860 ENOG4105C02 permease C5Y82_14880 ENOG410904N short-chain dehydrogenase reductase C5Y82_14915 ENOG4108K8K Transcriptional regulator C5Y82_14920 ENOG4105DCF alanine dehydrogenase C5Y82_14930 ENOG4108N23 SpoOM-related protein C5Y82_14940 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C5Y82_14950 ENOG41069ER domain protein C5Y82_14960 ENOG4105CEP NADH dehydrogenase C5Y82_14965 ENOG4105CAY ferredoxin--nadp reductase C5Y82_14980 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C5Y82_14985 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) C5Y82_14990 ENOG4105ZKE UPF0349 protein C5Y82_15010 ENOG41083MR nifu domain-containing protein C5Y82_15015 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C5Y82_15025 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C5Y82_15030 ENOG4105D6E homoserine dehydrogenase C5Y82_15035 ENOG4105C5I Dehydrogenase C5Y82_15045 ENOG4108W5N phosphatidylglycerophosphatase a C5Y82_15050 ENOG4105D4U had-superfamily hydrolase, subfamily iia C5Y82_15060 ENOG4105MMD transcriptional regulator C5Y82_15065 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C5Y82_15075 ENOG4105FAA peptidase M23 C5Y82_15080 ENOG4108YTE sporulation protein YunB C5Y82_15085 ENOG4105KZD Domain of unknown function (DUF1805) C5Y82_15090 ENOG4107R8B 5'-nucleotidase C5Y82_15095 ENOG4105I3N Conserved Protein C5Y82_15100 ENOG4105G9B Transcriptional regulator C5Y82_15105 ENOG4105F0F Oxalate decarboxylase C5Y82_15115 ENOG4105C5R Aminotransferase C5Y82_15120 ENOG4108K8S endonuclease I C5Y82_15130 ENOG4108IHU transport system permease protein C5Y82_15135 ENOG4105DQ5 transport system permease protein C5Y82_15140 ENOG4108MES Periplasmic binding protein C5Y82_15160 ENOG4108SWU Histidine kinase C5Y82_15165 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5Y82_15170 ENOG4105DHF Membrane C5Y82_15180 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C5Y82_15195 ENOG4105DIW FeS assembly protein SUFB C5Y82_15200 ENOG4108UNV SUF system FeS assembly protein, NifU family C5Y82_15205 ENOG4105C9B Cysteine desulfurase C5Y82_15210 ENOG4105JRK feS assembly protein SufD C5Y82_15215 ENOG4105C3K feS assembly ATPase SufC C5Y82_15230 ENOG4105D01 (LipO)protein C5Y82_15235 ENOG4108UMI ABC transporter, permease C5Y82_15240 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C5Y82_15265 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C5Y82_15270 ENOG41080E8 Transcriptional regulator, Spx MgsR family C5Y82_15275 ENOG4105C1G acyl-Coa dehydrogenase C5Y82_15280 ENOG4105CHU acetyl-coa acetyltransferase C5Y82_15310 ENOG4105E0A ABC, transporter C5Y82_15320 ENOG4105E1F short-chain dehydrogenase reductase C5Y82_15325 ENOG4105C0H protease C5Y82_15335 ENOG4105F3H Histidine kinase C5Y82_15340 ENOG41067SE Tetr family transcriptional regulator C5Y82_15345 ENOG4105C9Q fumarate hydratase class II C5Y82_15375 ENOG4105WH1 Two component transcriptional regulator luxr family C5Y82_15380 ENOG4105ENE Histidine kinase C5Y82_15395 ENOG41087YS Phage shock protein A C5Y82_15405 ENOG4108WBT adenosyltransferase C5Y82_15410 ENOG4105E0A ABC, transporter C5Y82_15415 ENOG4105EHG Permease protein C5Y82_15420 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C5Y82_15430 ENOG4105CTX dehydratase C5Y82_15435 ENOG4107QZW Altronate oxidoreductase C5Y82_15440 ENOG4107KJX Transcriptional regulator C5Y82_15445 ENOG4105D2H Uronic isomerase C5Y82_15455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C5Y82_15460 ENOG4105E0A ABC, transporter C5Y82_15465 ENOG4105EHG Permease protein C5Y82_15470 ENOG4105DQ5 transport system permease protein C5Y82_15480 ENOG4105D5Q Arginine ornithine antiporter C5Y82_15500 ENOG4107K5X Membrane-bound metal-dependent hydrolase C5Y82_15505 ENOG4107QZ2 Sulfatase C5Y82_15510 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C5Y82_15515 ENOG4105E0C molybdate abc transporter C5Y82_15525 ENOG4105EVU fructokinase C5Y82_15530 ENOG4107SUZ Sodium/hydrogen exchanger family C5Y82_15535 ENOG4105EN6 Membrane C5Y82_15545 ENOG4107ZQN disulfide bond C5Y82_15550 ENOG4105C59 p-type ATPase C5Y82_15555 ENOG4105DIK (ABC) transporter C5Y82_15560 ENOG4105CC5 ABC transporter C5Y82_15565 ENOG4105DSE periplasmic solute binding protein C5Y82_15570 ENOG4105IIP Membrane C5Y82_15575 ENOG4105W1N transcriptional regulator C5Y82_15590 ENOG4108IJ0 Aspartate ammonia-lyase C5Y82_15600 ENOG4105C59 p-type ATPase C5Y82_15605 ENOG410681U heavy metal transport detoxification protein C5Y82_15610 ENOG4105VPX protein, conserved in bacteria C5Y82_15620 ENOG4105BZU Histidine kinase C5Y82_15645 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C5Y82_15650 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C5Y82_15660 ENOG4105XZU Preprotein translocase, subunit SecG C5Y82_15685 ENOG4105KVH Transcriptional regulator C5Y82_15690 ENOG4105R40 Glycine betaine carnitine choline C5Y82_15695 ENOG4108HQR Glycine betaine C5Y82_15700 ENOG4105E90 ABC transporter C5Y82_15705 ENOG4108IJ8 ABC transporter C5Y82_15710 ENOG4107HG4 Transcriptional regulator C5Y82_15715 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C5Y82_15725 ENOG4108W0I acetyltransferase C5Y82_15745 ENOG4105CJ1 ABC, transporter C5Y82_15755 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C5Y82_15765 ENOG4105CP7 Triose-phosphate isomerase C5Y82_15770 ENOG4105BZA Phosphoglycerate kinase C5Y82_15775 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C5Y82_15790 ENOG4105C8Y Acetylornithine aminotransferase C5Y82_15795 ENOG4108JUB Transcriptional regulator C5Y82_15800 ENOG4105JXH GntR family transcriptional regulator C5Y82_15805 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C5Y82_15815 ENOG4107R73 Mate efflux family protein C5Y82_15820 ENOG4108JQ7 (ABC) transporter C5Y82_15825 ENOG4105C3U ABC transporter C5Y82_15830 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C5Y82_15835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5Y82_15840 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein C5Y82_15845 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5Y82_15850 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C5Y82_15855 ENOG4105D3Q Sugar transferase C5Y82_15870 ENOG4107QRS glycosyltransferase group 2 family protein C5Y82_15875 ENOG41068W6 Capsular polysaccharide biosynthesis protein C5Y82_15880 ENOG4108KMV Glycosyl transferase (Group 1 C5Y82_15885 ENOG4105K64 Glycosyl transferase, family 2 C5Y82_15890 ENOG4108PQP glycosyl transferase group 1 C5Y82_15900 ENOG4108QV3 biosynthesis protein C5Y82_15925 ENOG4105EHG Permease protein C5Y82_15930 ENOG4105DQ5 transport system permease protein C5Y82_15935 ENOG4108ZJ4 polysaccharide deacetylase C5Y82_15945 ENOG4108S9F abc transporter, atp-binding protein C5Y82_15960 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C5Y82_15965 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein C5Y82_16000 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C5Y82_16005 ENOG4108URH decarboxylase C5Y82_16010 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C5Y82_16015 ENOG4105CHH sulfate transporter C5Y82_16020 ENOG4108V2W Carbonate dehydratase C5Y82_16025 ENOG4105C5I Dehydrogenase C5Y82_16050 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C5Y82_16055 ENOG4105KRI phosphocarrier protein (HPr C5Y82_16060 ENOG4105CIE May be required for sporulation (By similarity) C5Y82_16065 ENOG4105CHW UPF0052 protein C5Y82_16070 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C5Y82_16075 ENOG4108Z4K mutator MutT protein C5Y82_16080 ENOG4105C3M thioredoxin reductase C5Y82_16095 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C5Y82_16100 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C5Y82_16105 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C5Y82_16110 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C5Y82_16115 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C5Y82_16120 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C5Y82_16125 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C5Y82_16130 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C5Y82_16145 ENOG4108RYK Nad-dependent epimerase dehydratase C5Y82_16150 ENOG4108Z40 Transcriptional regulator C5Y82_16155 ENOG4108S4C acetyltransferase C5Y82_16160 ENOG4107XGZ Hydrolase C5Y82_16165 ENOG4105HKU nucleoside recognition domain-containing protein C5Y82_16170 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C5Y82_16175 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C5Y82_16180 ENOG4105CE4 GlcNAc 6-P deacetylase C5Y82_16185 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C5Y82_16190 ENOG4105FDP GntR family transcriptional regulator C5Y82_16195 ENOG41088CQ domain protein C5Y82_16200 ENOG41086DT Membrane protein of unknown function C5Y82_16205 ENOG41067S9 phage shock protein C, PspC C5Y82_16210 ENOG4108PY7 C5Y82_16225 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C5Y82_16230 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C5Y82_16245 ENOG4105MKU Transcriptional regulator C5Y82_16260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Y82_16265 ENOG4105BZU Histidine kinase C5Y82_16270 ENOG4105EDW glycosyl transferase, family 39 C5Y82_16275 ENOG4105CKK Glycosyl transferase, family 2 C5Y82_16285 ENOG4108RCM Nitroreductase C5Y82_16290 ENOG4105KVH Transcriptional regulator C5Y82_16305 ENOG4105CN1 protease C5Y82_16320 ENOG4105CRP Part of the ABC transporter FtsEX involved in C5Y82_16325 ENOG4105CAK Cell division ATP-binding protein ftsE C5Y82_16360 ENOG4105MS2 ribosomal subunit Interface protein C5Y82_16365 ENOG4105C8Q Methyl-accepting chemotaxis C5Y82_16380 ENOG4105MQ3 flagellar protein FliS C5Y82_16385 ENOG4107RT6 flagellar hook-associated C5Y82_16390 ENOG41083S7 flagellar protein FlaG C5Y82_16395 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C5Y82_16400 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C5Y82_16405 ENOG4105MKD C5Y82_16410 ENOG4105DTJ flagellar hook-associated protein C5Y82_16415 ENOG4105E1Q flagellar hook-associated protein C5Y82_16430 ENOG4105RU3 C5Y82_16435 ENOG41081UC Inherit from COG: Competence protein C5Y82_16455 ENOG4105WH1 Two component transcriptional regulator luxr family C5Y82_16460 ENOG4105BZU Histidine kinase C5Y82_16465 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C5Y82_16470 ENOG4108KGH TRANSCRIPTIONal C5Y82_16475 ENOG4105ESV Glycosyl transferase, family 4 C5Y82_16480 ENOG4107EF8 Glycosyl transferase (Group 1 C5Y82_16495 ENOG4105QZI O-Antigen Polymerase C5Y82_16500 ENOG4105C1B dTDP-glucose 4-6-dehydratase C5Y82_16505 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5Y82_16510 ENOG4107RA4 Glycosyl transferase (Group 1 C5Y82_16515 ENOG4105PSV Polysaccharide Biosynthesis Protein C5Y82_16520 ENOG4105D3Q Sugar transferase C5Y82_16530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C5Y82_16535 ENOG4105JFG SpoIID LytB domain protein C5Y82_16550 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C5Y82_16555 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C5Y82_16565 ENOG4105EY8 ABC transporter C5Y82_16610 ENOG4107SJB teichoic acid biosynthesis C5Y82_16615 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) C5Y82_16620 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C5Y82_16630 ENOG4107RZX Teichoic acid biosynthesis protein C5Y82_16640 ENOG4107SJB teichoic acid biosynthesis C5Y82_16645 ENOG4105DG6 mannose-6-phosphate isomerase C5Y82_16655 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C5Y82_16660 ENOG4108JP0 extracellular solute-binding protein family 1 C5Y82_16665 ENOG4105WH1 Two component transcriptional regulator luxr family C5Y82_16670 ENOG4105C2F Histidine kinase C5Y82_16680 ENOG4105I4A GCN5-related N-acetyltransferase C5Y82_16685 ENOG4108UHU Aldolase C5Y82_16690 ENOG4105D7K pfkb domain protein C5Y82_16695 ENOG4108M60 Transcriptional regulator C5Y82_16700 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) C5Y82_16705 ENOG4105CHR reductase C5Y82_16720 ENOG4108NHD germination protein C5Y82_16725 ENOG4107QJZ Glycosyl transferase, family 2 C5Y82_16730 ENOG4105C54 Major Facilitator superfamily C5Y82_16735 ENOG4108KGH TRANSCRIPTIONal C5Y82_16740 ENOG4105J7I hydrolase C5Y82_16745 ENOG4105K4H Nlp p60 protein C5Y82_16750 ENOG4105PNM synthesis protein C5Y82_16760 ENOG4105N98 Capsule biosynthesis protein capB C5Y82_16780 ENOG4105ETE Transcriptional regulator (LacI family C5Y82_16785 ENOG4108RVA ribokinase C5Y82_16790 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C5Y82_16795 ENOG4105C2J ABC transporter C5Y82_16800 ENOG4105CNN ABC, transporter C5Y82_16805 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C5Y82_16810 ENOG4107XC4 flavin reductase domain protein, FMN-binding C5Y82_16815 ENOG4107RSM transcriptional regulator C5Y82_16825 ENOG4107FQX Alpha-acetolactate decarboxylase C5Y82_16835 ENOG4105CAH Chromate C5Y82_16840 ENOG4105FGV Chromate C5Y82_16845 ENOG4105C6Y Udp-glucose 6-dehydrogenase C5Y82_16850 ENOG4105KBK Zinc finger, swim domain protein C5Y82_16855 ENOG4105C0D helicase C5Y82_16860 ENOG4105BZU Histidine kinase C5Y82_16865 ENOG410667J hydrolase C5Y82_16880 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C5Y82_16885 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C5Y82_16895 ENOG4105CGA flagellar basal-body rod protein FlgG C5Y82_16905 ENOG4105DFF Rod shape-determining protein mreb C5Y82_16910 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C5Y82_16915 ENOG4107MII Sugar-specific transcriptional regulator TrmB C5Y82_16920 ENOG4105CZM Major Facilitator C5Y82_16925 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C5Y82_16930 ENOG41080V3 Major Facilitator superfamily C5Y82_16935 ENOG4105EAB amino acid AbC transporter C5Y82_16940 ENOG4105E5Q amino acid AbC transporter C5Y82_16945 ENOG4105CDA abc transporter atp-binding protein C5Y82_16955 ENOG4105BZU Histidine kinase C5Y82_16965 ENOG4105FRN stage II sporulation protein C5Y82_16970 ENOG4107TCE N-acetyltransferase C5Y82_17015 ENOG4105WDJ 50S ribosomal protein L33 C5Y82_17020 ENOG4105CKI cobalamin synthesis protein C5Y82_17025 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C5Y82_17040 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C5Y82_17045 ENOG4105FCD Major Facilitator C5Y82_17050 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit C5Y82_17055 ENOG4108TF4 von Willebrand factor, type A C5Y82_17070 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C5Y82_17080 ENOG4106778 Protein of unknown function (DUF1146) C5Y82_17090 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C5Y82_17095 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C5Y82_17100 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C5Y82_17105 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C5Y82_17125 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C5Y82_17135 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C5Y82_17140 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C5Y82_17145 ENOG4108UIC UPF0340 protein C5Y82_17150 ENOG4108YZG isomerase C5Y82_17155 ENOG4107WAU Protein tyrosine phosphatase C5Y82_17165 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C5Y82_17175 ENOG4108ZXQ stage ii sporulation protein r C5Y82_17185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C5Y82_17190 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C5Y82_17200 ENOG4107TT2 Auxin Efflux Carrier C5Y82_17205 ENOG4105C6K Malic enzyme C5Y82_17210 ENOG4107104 thymidine kinase C5Y82_17215 ENOG41082DI 50s ribosomal protein l31 C5Y82_17220 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C5Y82_17225 ENOG4105CBT Fructose-1,6-bisphosphatase C5Y82_17230 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C5Y82_17240 ENOG4105D2N Aldolase C5Y82_17245 ENOG410812K response regulator receiver protein C5Y82_17255 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C5Y82_17270 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C5Y82_17300 ENOG4105C1G acyl-Coa dehydrogenase C5Y82_17305 ENOG4105C1G acyl-Coa dehydrogenase C5Y82_17310 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C5Y82_17320 ENOG4105DF6 Fe-S oxidoreductase C5Y82_17340 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C5Y82_17345 ENOG4105BZ1 (ABC) transporter C5Y82_17350 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C5Y82_17365 ENOG4105C75 arginyL-tRNA synthetase C5Y82_17370 ENOG410684U Domain of unknown function (DUF1934) C5Y82_17380 ENOG4105CYW agmatinase C5Y82_17385 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C5Y82_17390 ENOG4105BZ4 penicillin-binding protein C5Y82_17395 ENOG4108XFG YwhD family C5Y82_17400 ENOG4108Z4T Peptidase M50 C5Y82_17405 ENOG41069HH 4-oxalocrotonate tautomerase C5Y82_17420 ENOG4105DCI Phosphohydrolase C5Y82_17425 ENOG4105QAT UPF0741 protein C5Y82_17430 ENOG4108VCI transcription factor, rsfa family C5Y82_17440 ENOG4107QZ7 Cellulose synthase catalytic subunit C5Y82_17450 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C5Y82_17470 ENOG4107EV6 Inherit from COG: YD repeat protein C5Y82_17505 ENOG4105JSC dimethylmenaquinone methyltransferase C5Y82_17515 ENOG4108IJ2 phosphate acetyltransferase C5Y82_17520 ENOG4107JTW chlorite dismutase C5Y82_17525 ENOG4105F27 Major Facilitator C5Y82_17535 ENOG4105FCW Major Facilitator superfamily C5Y82_17540 ENOG41061WN bacilysin biosynthesis protein C5Y82_17550 ENOG4105CHR reductase C5Y82_17555 ENOG4108M32 ATP-grasp domain C5Y82_17560 ENOG4105CHM Aminotransferase C5Y82_17570 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C5Y82_17575 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C5Y82_17580 ENOG4105C1B dTDP-glucose 4-6-dehydratase C5Y82_17585 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C5Y82_17590 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C5Y82_17595 ENOG4107TY6 Acylneuraminate cytidylyltransferase C5Y82_17605 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C5Y82_17610 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C5Y82_17655 ENOG4105C26 Dehydrogenase C5Y82_17660 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C5Y82_17665 ENOG4108RJ9 Glycosyl transferase, family 2 C5Y82_17675 ENOG4105DWF phosphomethylpyrimidine kinase C5Y82_17695 ENOG4105C5Y PTS System C5Y82_17710 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C5Y82_17720 ENOG4105DEN Luciferase family C5Y82_17725 ENOG4108DBC nitroreductase C5Y82_17745 ENOG41060D1 Quinol oxidase C5Y82_17750 ENOG4105CCU oxidase (Subunit III) C5Y82_17755 ENOG4105BZ9 Cytochrome C oxidase, subunit I C5Y82_17760 ENOG4105E2S oxidase) subunit II C5Y82_17775 ENOG4105CMR udp-glucose 4-epimerase C5Y82_17780 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C5Y82_17795 ENOG4105WH5 Teichoic acid glycosylation protein C5Y82_17855 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C5Y82_17860 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase C5Y82_17865 ENOG4105CMU LysR family (Transcriptional regulator C5Y82_17870 ENOG4105VAW lrga family C5Y82_17875 ENOG41067MG lrgb family C5Y82_17880 ENOG4105DR4 Methyltransferase C5Y82_17895 ENOG4105E5Q amino acid AbC transporter C5Y82_17900 ENOG4107R0W ABC transporter C5Y82_17915 ENOG4105CNN ABC, transporter C5Y82_17920 ENOG4105C2J ABC transporter C5Y82_17925 ENOG4108QGH periplasmic C5Y82_17930 ENOG4108M26 parallel beta-helix repeat protein C5Y82_17935 ENOG4105CM2 brancheD-chain amino acid aminotransferase C5Y82_17950 ENOG4105F8D glycoside hydrolase family 4 C5Y82_17955 ENOG4105VCP PTS System C5Y82_17960 ENOG4105CK1 PTS System C5Y82_17965 ENOG4105VZJ PTS System C5Y82_17970 ENOG4105EMD TRANSCRIPTIONal C5Y82_17985 ENOG4107R37 Glutamate dehydrogenase C5Y82_18005 ENOG4108J20 pectate lyase C5Y82_18010 ENOG4108JJ8 (ABC) transporter C5Y82_18015 ENOG4108JJ9 ABC, transporter C5Y82_18020 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C5Y82_18025 ENOG4105C4M (Ubiquinol oxidase) subunit I C5Y82_18035 ENOG4105S6R Iron-hydroxamate transporter permease subunit C5Y82_18045 ENOG4105KFN sortase, SrtB family C5Y82_18065 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) C5Y82_18070 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) C5Y82_18075 ENOG4105KVH Transcriptional regulator C5Y82_18080 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C5Y82_18085 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C5Y82_18090 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C5Y82_18100 ENOG4107BJW polysaccharide deacetylase C5Y82_18105 ENOG4105VCP PTS System C5Y82_18110 ENOG4105VZJ PTS System C5Y82_18115 ENOG4105CS2 ec 3.2.1.21 C5Y82_18125 ENOG4105CK1 PTS System C5Y82_18130 ENOG4105EMD TRANSCRIPTIONal C5Y82_18155 ENOG4105DFD Na H antiporter C5Y82_18160 ENOG4108IJ0 Aspartate ammonia-lyase C5Y82_18165 ENOG4105HDK L-asparaginase C5Y82_18170 ENOG4108IMY Transcriptional regulator C5Y82_18200 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C5Y82_18215 ENOG4106KNT transcriptional regulator C5Y82_18220 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C5Y82_18230 ENOG4105C6Z Gluconate C5Y82_18245 ENOG4105C19 ABC transporter C5Y82_18250 ENOG4105CS2 ec 3.2.1.21 C5Y82_18255 ENOG4105C5Y PTS System C5Y82_18260 ENOG4105CID antiterminator C5Y82_18265 ENOG4108XI2 Domain of unknown function (DUF1963) C5Y82_18275 ENOG4108W7F transporter, permease C5Y82_18280 ENOG4108JJB ABC transporter C5Y82_18285 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C5Y82_18290 ENOG4105ETU transcriptional activator (TenA C5Y82_18315 ENOG4107G87 m6 family metalloprotease domain protein C5Y82_18320 ENOG41067V3 Antibiotic biosynthesis monooxygenase C5Y82_18325 ENOG4108TVJ Nitroreductase C5Y82_18330 ENOG4105FS7 Transcriptional regulator C5Y82_18335 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C5Y82_18340 ENOG4105D9N nucleoside C5Y82_18345 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) C5Y82_18350 ENOG4107RHR regulatoR C5Y82_18365 ENOG4105EXC Acyl-transferase C5Y82_18370 ENOG4105DXI Major Facilitator superfamily C5Y82_18390 ENOG410667J hydrolase C5Y82_18395 ENOG4105W1Y Transcriptional regulator C5Y82_18400 ENOG4105EE0 oxidoreductase C5Y82_18405 ENOG4105FKZ Methyl-accepting chemotaxis C5Y82_18415 ENOG4105F1N DNA alkylation repair C5Y82_18420 ENOG4105C6Z Gluconate C5Y82_18425 ENOG4105CMG Carbohydrate kinase C5Y82_18430 ENOG4106KNT transcriptional regulator C5Y82_18460 ENOG4105DUM transcriptional regulator, lysR family C5Y82_18470 ENOG4107FKK extracellular solute-binding protein family 1 C5Y82_18480 ENOG4105EG2 ABC transporter, permease C5Y82_18490 ENOG4105C4C beta-galactosidase C5Y82_18505 ENOG4108TU7 Inherit from COG: (ABC) transporter C5Y82_18510 ENOG4105CJ1 ABC, transporter C5Y82_18515 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C5Y82_18520 ENOG4105BZW Glycerate kinase C5Y82_18525 ENOG4107QQ0 gntp family C5Y82_18530 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR C5Y82_18535 ENOG4105YA8 Transcriptional regulator C5Y82_18540 ENOG4107Y80 Major Facilitator superfamily C5Y82_18550 ENOG4105C19 ABC transporter C5Y82_18560 ENOG410780I phosphoprotein phosphatase activity C5Y82_18565 ENOG4105CID antiterminator C5Y82_18570 ENOG4105CS2 ec 3.2.1.21 C5Y82_18575 ENOG4105C5Y PTS System C5Y82_18615 ENOG4105C85 amino acid C5Y82_18620 ENOG4105ETE Transcriptional regulator (LacI family C5Y82_18630 ENOG4105E2X shikimate dehydrogenase C5Y82_18650 ENOG4105CS2 ec 3.2.1.21 C5Y82_18655 ENOG4108S3Y transcriptional regulator C5Y82_18670 ENOG4105JAB phenazine biosynthesis protein, phzf family C5Y82_18675 ENOG41080UQ Transcriptional regulator C5Y82_18710 ENOG4105C4R Atp-dependent dna helicase C5Y82_18725 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C5Y82_18735 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C5Y82_18745 ENOG4108V7D UPF0397 protein C5Y82_18765 ENOG4105WQG acetyltransferase C5Y82_18770 ENOG4105C0H protease C5Y82_18775 ENOG4105Q2H domain protein C5Y82_18790 ENOG4105BZU Histidine kinase C5Y82_18795 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C5Y82_18820 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C5Y82_18835 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C5Y82_18840 ENOG4105ST3 Transcriptional regulator C5Y82_18845 ENOG4106A3M Cytochrome p-450 C5Y82_18850 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C5Y82_18855 ENOG4105CDU Replicative dna helicase C5Y82_18860 ENOG4106K80 C5Y82_18865 ENOG4106K80 C5Y82_18875 ENOG4105NIV Esterase C5Y82_18880 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C5Y82_18885 ENOG4105E4F Isochorismate synthase C5Y82_18890 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C5Y82_18895 ENOG4105WQI isochorismatase C5Y82_18900 ENOG4105CEY Amp-dependent synthetase and ligase C5Y82_18905 ENOG4105WQT MbtH domain protein C5Y82_18910 ENOG410874W AraC family transcriptional regulator C5Y82_18920 ENOG4108SA1 esterase C5Y82_18930 ENOG4105DJ2 Major Facilitator Superfamily C5Y82_18940 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C5Y82_18945 ENOG4105BZR domain protein C5Y82_18950 ENOG4108XMW Membrane C5Y82_18955 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C5Y82_18960 ENOG4108P49 AntiSigma factor C5Y82_18965 ENOG4105JVQ RNA Polymerase C5Y82_18975 ENOG4105CH6 catalase C5Y82_18980 ENOG4105CS1 NAD(P)H quinone oxidoreductase C5Y82_18985 ENOG4105FBA Phospholipase Carboxylesterase C5Y82_18990 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C5Y82_18995 ENOG4105E90 ABC transporter C5Y82_19000 ENOG4108IJ8 ABC transporter C5Y82_19005 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C5Y82_19010 ENOG4108UUM single-stranded DNA-binding protein C5Y82_19015 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C5Y82_19020 ENOG4105C3G gtp-binding protein C5Y82_19025 ENOG4105VDK protein, conserved in bacteria C5Y82_19045 ENOG4108ZDA Sporulation protein YyaC C5Y82_19050 ENOG4105FA0 parb-like partition protein C5Y82_19055 ENOG4107QJE Chromosome Partitioning Protein C5Y82_19075 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C5Y82_19080 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C5Y82_19085 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C5Y82_19095 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C5Y82_19100 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)