locus-tag	class	description
K4A85_00015	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4A85_00020	COG0022	dehydrogenase e1 component
K4A85_00020	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_00025	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_00030	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A85_00035	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_00045	COG2390	Transcriptional regulator
K4A85_00055	COG0531	amino acid
K4A85_00065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A85_00070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4A85_00075	COG2362	D-Aminopeptidase
K4A85_00080	COG0601	transmembrane transport
K4A85_00085	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4A85_00090	COG0444	Belongs to the ABC transporter superfamily
K4A85_00095	COG4166	transmembrane transport
K4A85_00100	COG1619	proteins homologs of microcin C7 resistance protein MccF
K4A85_00105	COG4948	Mandelate Racemase Muconate Lactonizing
K4A85_00110	COG0791	NLP P60 protein
K4A85_00115	COG4608	Belongs to the ABC transporter superfamily
K4A85_00120	COG1834	amidinotransferase
K4A85_00125	COG1607	acyl-coa hydrolase
K4A85_00130	COG1695	Transcriptional regulator
K4A85_00145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4A85_00155	COG2076	Multidrug Resistance protein
K4A85_00160	COG2076	Multidrug Resistance protein
K4A85_00170	COG0788	formyltetrahydrofolate deformylase activity
K4A85_00175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K4A85_00180	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K4A85_00185	COG0457	Tetratricopeptide repeat
K4A85_00195	COG1764	response to oxidative stress
K4A85_00200	COG1846	Transcriptional regulator
K4A85_00205	COG1764	response to oxidative stress
K4A85_00210	COG0590	tRNA wobble adenosine to inosine editing
K4A85_00215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K4A85_00220	COG1404	Belongs to the peptidase S8 family
K4A85_00225	COG0745	RESPONSE REGULATOR receiver
K4A85_00235	COG3212	peptidase
K4A85_00240	COG3212	peptidase
K4A85_00250	COG2239	Acts as a magnesium transporter
K4A85_00260	COG0583	DNA-binding transcription factor activity
K4A85_00270	COG0789	Transcriptional regulator
K4A85_00285	COG1846	Transcriptional regulator
K4A85_00290	COG3300	MHYT domain
K4A85_00290	COG5001	Diguanylate cyclase
K4A85_00295	COG0586	Pfam SNARE associated Golgi protein
K4A85_00300	COG0861	Integral membrane protein TerC family
K4A85_00305	COG1191	sigma factor activity
K4A85_00325	COG0501	Belongs to the peptidase M48B family
K4A85_00330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K4A85_00335	COG2323	membrane
K4A85_00350	COG3594	Acyltransferase
K4A85_00355	COG5002	protein histidine kinase activity
K4A85_00360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K4A85_00365	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K4A85_00370	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K4A85_00375	COG0436	Aminotransferase
K4A85_00380	COG1850	ribulose-bisphosphate carboxylase activity
K4A85_00385	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K4A85_00390	COG0235	Class ii aldolase
K4A85_00395	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K4A85_00405	COG3852	Histidine kinase
K4A85_00410	COG1846	Transcriptional regulator
K4A85_00415	COG1360	Flagellar Motor Protein
K4A85_00420	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K4A85_00425	COG0542	response to heat
K4A85_00430	COG3949	Membrane
K4A85_00435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K4A85_00440	COG0720	synthase
K4A85_00445	COG0602	queuosine metabolic process
K4A85_00460	COG3773	Cell wall hydrolase
K4A85_00475	COG0006	proline dipeptidase activity
K4A85_00485	COG1609	Transcriptional regulator
K4A85_00490	COG3711	transcriptional antiterminator
K4A85_00525	COG2084	Dehydrogenase
K4A85_00530	COG2340	Cysteine-rich secretory protein family
K4A85_00535	COG0768	penicillin binding
K4A85_00540	COG4191	Histidine kinase
K4A85_00545	COG0436	Aminotransferase
K4A85_00550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K4A85_00560	COG1714	RDD family
K4A85_00570	COG0784	Response regulator, receiver
K4A85_00570	COG0835	chemotaxis
K4A85_00585	COG2814	Major facilitator Superfamily
K4A85_00590	COG1376	ErfK ybiS ycfS ynhG family protein
K4A85_00595	COG1408	metallophosphoesterase
K4A85_00600	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_00605	COG2200	EAL domain
K4A85_00610	COG3546	catalase activity
K4A85_00615	COG4703	Protein of unknown function (DUF1797)
K4A85_00620	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K4A85_00630	COG0517	IMP dehydrogenase activity
K4A85_00635	COG0583	DNA-binding transcription factor activity
K4A85_00645	COG0716	FMN binding
K4A85_00655	COG0716	FMN binding
K4A85_00660	COG2171	N-acyltransferase activity
K4A85_00665	COG1473	amidohydrolase
K4A85_00680	COG0450	alkyl hydroperoxide reductase
K4A85_00685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_00700	COG0746	molybdenum cofactor guanylyltransferase activity
K4A85_00705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K4A85_00710	COG0303	'Molybdopterin
K4A85_00715	COG1763	Mo-molybdopterin cofactor biosynthetic process
K4A85_00720	COG0314	molybdopterin synthase activity
K4A85_00725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K4A85_00740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K4A85_00745	COG1136	(ABC) transporter
K4A85_00750	COG0577	efflux transmembrane transporter activity
K4A85_00755	COG1349	DNA-binding transcription factor activity
K4A85_00760	COG1105	Belongs to the carbohydrate kinase PfkB family
K4A85_00765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_00765	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A85_00765	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A85_00780	COG0488	(ABC) transporter
K4A85_00810	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K4A85_00810	COG2105	PFAM AIG2 family protein
K4A85_00815	COG0569	domain protein
K4A85_00830	COG5503	Protein of unknown function (DUF1447)
K4A85_00835	COG0561	phosphatase activity
K4A85_00840	COG0242	peptide deformylase activity
K4A85_00855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4A85_00860	COG0022	dehydrogenase e1 component
K4A85_00865	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_00870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A85_00875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_00885	COG1982	Orn Lys Arg decarboxylase major
K4A85_00890	COG4476	Belongs to the UPF0223 family
K4A85_00895	COG4493	Belongs to the UPF0637 family
K4A85_00905	COG0483	inositol monophosphate 1-phosphatase activity
K4A85_00920	COG1595	DNA-templated transcription, initiation
K4A85_00950	COG4896	Protein conserved in bacteria
K4A85_00960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K4A85_00965	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K4A85_00970	COG2066	Belongs to the glutaminase family
K4A85_00975	COG4838	Belongs to the UPF0358 family
K4A85_00980	COG0772	Belongs to the SEDS family
K4A85_00985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K4A85_00990	COG0415	Belongs to the DNA photolyase family
K4A85_00995	COG1612	heme a metabolic process
K4A85_01000	COG0109	protoheme IX farnesyltransferase activity
K4A85_01005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K4A85_01005	COG2010	Cytochrome c
K4A85_01010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K4A85_01015	COG1845	cytochrome c oxidase, subunit III
K4A85_01020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K4A85_01025	COG3336	cytochrome c oxidase
K4A85_01035	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K4A85_01040	COG2340	Cysteine-rich secretory protein family
K4A85_01060	COG3679	Belongs to the UPF0342 family
K4A85_01065	COG4471	UPF0298 protein
K4A85_01070	COG0742	ribosomal rna small subunit methyltransferase
K4A85_01075	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K4A85_01080	COG3314	Sporulation integral membrane protein YlbJ
K4A85_01085	COG1752	Esterase of the alpha-beta hydrolase superfamily
K4A85_01090	COG3480	Lon protease (S16) C-terminal proteolytic domain
K4A85_01100	COG1399	metal-binding, possibly nucleic acid-binding protein
K4A85_01105	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K4A85_01115	COG0454	-acetyltransferase
K4A85_01120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K4A85_01125	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K4A85_01130	COG2001	Belongs to the MraZ family
K4A85_01135	COG0275	rRNA processing
K4A85_01140	COG4839	cell division protein FtsL
K4A85_01145	COG0768	penicillin binding
K4A85_01150	COG0768	penicillin binding
K4A85_01155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K4A85_01160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4A85_01165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K4A85_01170	COG0772	Belongs to the SEDS family
K4A85_01175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4A85_01180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K4A85_01185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K4A85_01190	COG3879	Bacterial protein of unknown function (DUF881)
K4A85_01195	COG3879	Bacterial protein of unknown function (DUF881)
K4A85_01200	COG3856	small basic protein
K4A85_01205	COG0849	cell division
K4A85_01210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K4A85_01215	COG4412	M6 family metalloprotease domain protein
K4A85_01215	COG1404	Belongs to the peptidase S8 family
K4A85_01225	COG1191	sigma factor activity
K4A85_01230	COG1191	sigma factor activity
K4A85_01235	COG2390	Transcriptional regulator
K4A85_01250	COG3730	PTS system glucitol sorbitol-specific
K4A85_01255	COG3732	PTS system glucitol sorbitol-specific
K4A85_01265	COG1119	ATPase activity
K4A85_01270	COG1873	PFAM PRC-barrel domain
K4A85_01275	COG1496	oxidoreductase activity
K4A85_01280	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K4A85_01285	COG1799	cell septum assembly
K4A85_01290	COG0762	integral membrane protein
K4A85_01295	COG2302	S4 RNA-binding domain
K4A85_01300	COG3599	regulation of cell shape
K4A85_01305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K4A85_01310	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K4A85_01315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K4A85_01320	COG0564	pseudouridine synthase activity
K4A85_01325	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K4A85_01330	COG2233	PERMEase
K4A85_01335	COG0540	Belongs to the ATCase OTCase family
K4A85_01340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K4A85_01345	COG0505	Belongs to the CarA family
K4A85_01350	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K4A85_01355	COG0543	2 iron, 2 sulfur cluster binding
K4A85_01360	COG0167	dihydroorotate dehydrogenase activity
K4A85_01365	COG0284	orotidine-5'-phosphate decarboxylase activity
K4A85_01370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K4A85_01380	COG0175	sulfate reduction
K4A85_01385	COG0306	phosphate transporter
K4A85_01390	COG2046	Belongs to the sulfate adenylyltransferase family
K4A85_01395	COG0529	Catalyzes the synthesis of activated sulfate
K4A85_01400	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K4A85_01405	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
K4A85_01410	COG1648	precorrin-2 dehydrogenase activity
K4A85_01420	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K4A85_01425	COG1561	YicC-like family, N-terminal region
K4A85_01430	COG2052	Domain of unknown function (DUF370)
K4A85_01435	COG0194	GDP metabolic process
K4A85_01440	COG1758	RNA polymerase activity
K4A85_01445	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K4A85_01485	COG1162	GTPase activity
K4A85_01490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K4A85_01495	COG1564	THIamine pyrophosphokinase
K4A85_01505	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K4A85_01510	COG1302	Protein conserved in bacteria
K4A85_01515	COG1461	Dihydroxyacetone kinase
K4A85_01520	COG1760	l-serine dehydratase
K4A85_01525	COG1760	l-serine dehydratase
K4A85_01530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K4A85_01535	COG1349	DNA-binding transcription factor activity
K4A85_01540	COG0416	fatty acid biosynthetic process
K4A85_01545	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K4A85_01550	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_01555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4A85_01565	COG1196	nuclear chromosome segregation
K4A85_01570	COG0552	protein localization to endoplasmic reticulum
K4A85_01575	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K4A85_01580	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K4A85_01585	COG0228	four-way junction DNA binding
K4A85_01590	COG1837	Belongs to the UPF0109 family
K4A85_01600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K4A85_01605	COG0336	Belongs to the RNA methyltransferase TrmD family
K4A85_01610	COG0335	large ribosomal subunit rRNA binding
K4A85_01615	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K4A85_01620	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K4A85_01630	COG2257	FlhB HrpN YscU SpaS Family
K4A85_01635	COG0045	succinate-CoA ligase (ADP-forming) activity
K4A85_01640	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K4A85_01645	COG0758	DNA mediated transformation
K4A85_01650	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K4A85_01655	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K4A85_01660	COG4974	Belongs to the 'phage' integrase family
K4A85_01665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K4A85_01670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K4A85_01675	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K4A85_01680	COG1815	bacterial-type flagellum-dependent cell motility
K4A85_01685	COG1558	bacterial-type flagellum-dependent cell motility
K4A85_01690	COG1677	Flagellar hook-basal body complex protein FliE
K4A85_01695	COG1766	The M ring may be actively involved in energy transduction
K4A85_01700	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K4A85_01705	COG1317	bacterial-type flagellum organization
K4A85_01710	COG1157	protein secretion by the type III secretion system
K4A85_01715	COG2882	bacterial-type flagellum organization
K4A85_01720	COG3334	PFAM MgtE intracellular
K4A85_01725	COG3144	bacterial-type flagellum assembly
K4A85_01730	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K4A85_01735	COG4786	Flagellar basal body rod
K4A85_01740	COG1582	Flagellar protein (FlbD)
K4A85_01745	COG1580	Controls the rotational direction of flagella during chemotaxis
K4A85_01750	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K4A85_01755	COG1776	CheC inhibitor of MCP methylation
K4A85_01755	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K4A85_01760	COG2201	protein-glutamate methylesterase activity
K4A85_01775	COG1987	bacterial-type flagellum assembly
K4A85_01780	COG1684	flagellar biosynthetic protein fliR
K4A85_01785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4A85_01790	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K4A85_01795	COG1419	protein localization to endoplasmic reticulum
K4A85_01800	COG0455	bacterial-type flagellum organization
K4A85_01805	COG2201	protein-glutamate methylesterase activity
K4A85_01810	COG2198	Histidine kinase
K4A85_01810	COG0643	Histidine kinase
K4A85_01815	COG0835	chemotaxis
K4A85_01820	COG1776	CheC inhibitor of MCP methylation
K4A85_01830	COG1191	sigma factor activity
K4A85_01840	COG0052	Belongs to the universal ribosomal protein uS2 family
K4A85_01845	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K4A85_01850	COG0528	UMP kinase activity
K4A85_01855	COG0233	cytoplasmic translational termination
K4A85_01860	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K4A85_01865	COG4589	Belongs to the CDS family
K4A85_01870	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K4A85_01875	COG0750	zinc metalloprotease
K4A85_01880	COG0442	prolyl-tRNA aminoacylation
K4A85_01885	COG2176	DNA-directed DNA polymerase activity
K4A85_01900	COG3693	PFAM glycoside hydrolase, family 10
K4A85_01910	COG0779	Required for maturation of 30S ribosomal subunits
K4A85_01915	COG0195	Participates in both transcription termination and antitermination
K4A85_01920	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K4A85_01925	COG1358	cellular component organization or biogenesis
K4A85_01930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K4A85_01935	COG1550	Protein conserved in bacteria
K4A85_01940	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K4A85_01945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K4A85_01950	COG0196	riboflavin kinase activity
K4A85_01955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K4A85_01960	COG1185	polyribonucleotide nucleotidyltransferase activity
K4A85_01965	COG0726	polysaccharide deacetylase
K4A85_01970	COG0612	Peptidase, M16
K4A85_01980	COG1873	PFAM PRC-barrel domain
K4A85_01985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K4A85_01990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K4A85_01995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K4A85_02000	COG0527	aspartate kinase activity
K4A85_02010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K4A85_02015	COG0740	serine-type endopeptidase activity
K4A85_02025	COG1674	ftsk spoiiie
K4A85_02025	COG4980	gas vesicle protein
K4A85_02030	COG2188	Transcriptional regulator
K4A85_02035	COG2814	Major facilitator Superfamily
K4A85_02040	COG1033	growth of symbiont in host cell
K4A85_02040	COG2409	Drug exporters of the RND superfamily
K4A85_02045	COG0612	Peptidase, M16
K4A85_02050	COG0612	Peptidase, M16
K4A85_02060	COG1033	growth of symbiont in host cell
K4A85_02060	COG2409	Drug exporters of the RND superfamily
K4A85_02065	COG0300	oxidoreductase activity
K4A85_02080	COG1426	Protein conserved in bacteria
K4A85_02085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K4A85_02090	COG1546	Belongs to the CinA family
K4A85_02090	COG1058	Belongs to the CinA family
K4A85_02095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K4A85_02100	COG1418	mRNA catabolic process
K4A85_02105	COG1692	metallophosphoesterase
K4A85_02110	COG2359	stage V sporulation protein S
K4A85_02115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A85_02120	COG1063	alcohol dehydrogenase
K4A85_02125	COG0156	8-amino-7-oxononanoate synthase activity
K4A85_02130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K4A85_02135	COG4550	Control of competence regulator ComK, YlbF/YmcA
K4A85_02145	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K4A85_02165	COG1329	Transcriptional regulator
K4A85_02170	COG4195	phage-related replication protein
K4A85_02175	COG0457	Tetratricopeptide repeat
K4A85_02180	COG1404	Belongs to the peptidase S8 family
K4A85_02185	COG4195	phage-related replication protein
K4A85_02190	COG1764	response to oxidative stress
K4A85_02195	COG2076	Multidrug Resistance protein
K4A85_02220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K4A85_02225	COG1923	regulation of RNA biosynthetic process
K4A85_02240	COG1780	Probably involved in ribonucleotide reductase function
K4A85_02245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4A85_02250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K4A85_02255	COG4112	unkown
K4A85_02265	COG0464	growth
K4A85_02270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K4A85_02275	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K4A85_02280	COG0789	Transcriptional regulator
K4A85_02305	COG5646	InterPro IPR014922
K4A85_02315	COG0457	Tetratricopeptide repeat
K4A85_02325	COG3619	membrane
K4A85_02330	COG1793	dna ligase
K4A85_02330	COG3285	dna ligase
K4A85_02335	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K4A85_02340	COG4876	unkown
K4A85_02350	COG1959	2 iron, 2 sulfur cluster binding
K4A85_02355	COG0702	epimerase
K4A85_02380	COG1131	(ABC) transporter
K4A85_02385	COG0247	lactate metabolic process
K4A85_02390	COG1139	Iron-sulfur cluster binding protein
K4A85_02395	COG1556	Lactate utilization protein
K4A85_02420	COG1309	transcriptional regulator
K4A85_02425	COG2124	cytochrome p450
K4A85_02425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K4A85_02430	COG3591	Belongs to the peptidase S1B family
K4A85_02435	COG3209	COG3209 Rhs family protein
K4A85_02440	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_02455	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K4A85_02460	COG1388	LysM domain
K4A85_02465	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K4A85_02470	COG4224	UPF0291 protein
K4A85_02475	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K4A85_02485	COG3763	UPF0154 protein
K4A85_02495	COG0785	Cytochrome C biogenesis protein
K4A85_02500	COG4846	Membrane protein involved in cytochrome C biogenesis
K4A85_02510	COG0071	Belongs to the small heat shock protein (HSP20) family
K4A85_02525	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K4A85_02530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_02560	COG4841	protein insertion into membrane
K4A85_02565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K4A85_02570	COG1832	CoA-binding protein
K4A85_02575	COG0187	DNA topoisomerase II activity
K4A85_02580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K4A85_02590	COG0738	Major facilitator superfamily
K4A85_02595	COG0473	3-isopropylmalate dehydrogenase activity
K4A85_02610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4A85_02615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K4A85_02620	COG0640	Transcriptional regulator
K4A85_02625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K4A85_02630	COG0251	oxidation-reduction process
K4A85_02655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K4A85_02675	COG0657	acetylesterase activity
K4A85_02685	COG2205	protein histidine kinase activity
K4A85_02690	COG0745	RESPONSE REGULATOR receiver
K4A85_02700	COG3507	Belongs to the glycosyl hydrolase 43 family
K4A85_02705	COG1012	belongs to the aldehyde dehydrogenase family
K4A85_02710	COG1486	melibiose metabolic process
K4A85_02715	COG0395	ABC-type sugar transport system, permease component
K4A85_02720	COG1175	transmembrane transport
K4A85_02725	COG1653	transport
K4A85_02730	COG1609	Transcriptional regulator
K4A85_02735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K4A85_02750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_02760	COG1846	Transcriptional regulator
K4A85_02765	COG2814	Major facilitator Superfamily
K4A85_02775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_02775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A85_02775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A85_02780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_02780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A85_02780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K4A85_02785	COG1105	Belongs to the carbohydrate kinase PfkB family
K4A85_02795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A85_02830	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4A85_02835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K4A85_02840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K4A85_02845	COG1024	Enoyl-CoA hydratase
K4A85_02850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4A85_02855	COG0511	ligase activity, forming carbon-carbon bonds
K4A85_02860	COG0439	Biotin carboxylase
K4A85_02865	COG0318	PFAM AMP-dependent synthetase and ligase
K4A85_02870	COG1960	acyl-CoA dehydrogenase activity
K4A85_02875	COG1649	PFAM Uncharacterised BCR, COG1649
K4A85_02880	COG2365	Tyrosine phosphatase family
K4A85_02885	COG1349	DNA-binding transcription factor activity
K4A85_02895	COG3835	regulator
K4A85_02900	COG0277	FAD linked oxidase domain protein
K4A85_02905	COG0247	lactate metabolic process
K4A85_02930	COG0166	Belongs to the GPI family
K4A85_02935	COG0586	Pfam SNARE associated Golgi protein
K4A85_02940	COG1587	Uroporphyrinogen-III synthase
K4A85_02950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4A85_02970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4A85_02975	COG1846	Transcriptional regulator
K4A85_02985	COG2085	NADP oxidoreductase coenzyme F420-dependent
K4A85_03005	COG0534	Mate efflux family protein
K4A85_03010	COG2027	D-alanyl-D-alanine carboxypeptidase
K4A85_03015	COG4677	pectinesterase activity
K4A85_03020	COG2323	membrane
K4A85_03025	COG2146	nitrite reductase [NAD(P)H] activity
K4A85_03030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4A85_03035	COG0243	molybdopterin cofactor binding
K4A85_03040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K4A85_03045	COG2223	nitrite transmembrane transporter activity
K4A85_03050	COG0493	'glutamate synthase
K4A85_03055	COG0070	glutamate synthase
K4A85_03055	COG0067	glutamate synthase
K4A85_03055	COG0069	glutamate synthase activity
K4A85_03060	COG0583	DNA-binding transcription factor activity
K4A85_03080	COG0454	-acetyltransferase
K4A85_03085	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K4A85_03090	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K4A85_03105	COG0243	molybdopterin cofactor binding
K4A85_03120	COG2115	Belongs to the xylose isomerase family
K4A85_03125	COG1940	carbohydrate kinase activity
K4A85_03135	COG2211	Major facilitator Superfamily
K4A85_03140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A85_03145	COG1994	Peptidase M50
K4A85_03165	COG1309	transcriptional regulator
K4A85_03170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A85_03175	COG3708	Transcriptional regulator
K4A85_03180	COG2378	regulation of single-species biofilm formation
K4A85_03190	COG0640	Transcriptional regulator
K4A85_03195	COG0531	amino acid
K4A85_03200	COG0741	lytic transglycosylase activity
K4A85_03210	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K4A85_03215	COG2079	MmgE PrpD family protein
K4A85_03220	COG0372	Belongs to the citrate synthase family
K4A85_03225	COG2322	membrane
K4A85_03235	COG1388	LysM domain
K4A85_03235	COG3584	3D domain protein
K4A85_03240	COG0514	ATP-dependent DNA helicase (RecQ)
K4A85_03250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K4A85_03275	COG1012	belongs to the aldehyde dehydrogenase family
K4A85_03280	COG1657	PFAM Prenyltransferase squalene oxidase
K4A85_03285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K4A85_03290	COG0385	Bile acid
K4A85_03295	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_03300	COG0567	Dehydrogenase, E1 component
K4A85_03310	COG0714	Associated with various cellular activities
K4A85_03315	COG2032	superoxide dismutase activity
K4A85_03320	COG1388	LysM domain
K4A85_03320	COG0791	NLP P60 protein
K4A85_03325	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K4A85_03330	COG0534	Mate efflux family protein
K4A85_03335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4A85_03340	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4A85_03350	COG2962	Rard protein
K4A85_03365	COG1733	regulation of RNA biosynthetic process
K4A85_03370	COG0778	Nitroreductase
K4A85_03380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4A85_03385	COG0793	Belongs to the peptidase S41A family
K4A85_03385	COG3409	Peptidoglycan-binding domain 1 protein
K4A85_03390	COG2226	methyltransferase
K4A85_03400	COG1876	peptidase activity
K4A85_03445	COG3829	transcription factor binding
K4A85_03450	COG0463	Glycosyl transferase, family 2
K4A85_03465	COG4641	Protein conserved in bacteria
K4A85_03475	COG1086	Polysaccharide biosynthesis protein
K4A85_03480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K4A85_03485	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K4A85_03490	COG1846	Transcriptional regulator
K4A85_03505	COG4698	Protein conserved in bacteria
K4A85_03510	COG2755	lipolytic protein G-D-S-L family
K4A85_03515	COG1999	signal sequence binding
K4A85_03530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K4A85_03535	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K4A85_03540	COG1272	protein, Hemolysin III
K4A85_03545	COG0204	Acyl-transferase
K4A85_03550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K4A85_03555	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K4A85_03560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K4A85_03570	COG2136	Putative SAM-dependent methyltransferase
K4A85_03570	COG2521	methyltransferase
K4A85_03580	COG0129	dihydroxy-acid dehydratase activity
K4A85_03585	COG1413	lyase activity
K4A85_03590	COG1418	mRNA catabolic process
K4A85_03595	COG0386	Belongs to the glutathione peroxidase family
K4A85_03600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
K4A85_03605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K4A85_03610	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K4A85_03620	COG1278	Cold shock
K4A85_03635	COG0328	RNA-DNA hybrid ribonuclease activity
K4A85_03640	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K4A85_03645	COG0328	RNA-DNA hybrid ribonuclease activity
K4A85_03655	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A85_03665	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K4A85_03675	COG1755	Isoprenylcysteine carboxyl methyltransferase
K4A85_03680	COG3424	synthase
K4A85_03690	COG0726	polysaccharide deacetylase
K4A85_03695	COG2233	PERMEase
K4A85_03700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4A85_03720	COG0116	Belongs to the methyltransferase superfamily
K4A85_03730	COG3599	regulation of cell shape
K4A85_03735	COG4474	Belongs to the UPF0398 family
K4A85_03745	COG3359	exonuclease
K4A85_03750	COG1205	dead DEAH box helicase
K4A85_03750	COG1111	helicase
K4A85_03755	COG1902	pentaerythritol trinitrate reductase activity
K4A85_03760	COG2190	(PTS) system
K4A85_03765	COG0071	Belongs to the small heat shock protein (HSP20) family
K4A85_03795	COG3331	DNA recombination
K4A85_03800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A85_03800	COG4499	WXG100 protein secretion system (Wss), protein YukC
K4A85_03810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K4A85_03815	COG3935	DnaD domain protein
K4A85_03820	COG0017	Asparaginyl-tRNA synthetase
K4A85_03825	COG5353	protein conserved in bacteria
K4A85_03835	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K4A85_03835	COG1199	ATP-dependent helicase activity
K4A85_03840	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K4A85_03845	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K4A85_03850	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K4A85_03865	COG0438	transferase activity, transferring glycosyl groups
K4A85_03870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K4A85_03875	COG1803	Methylglyoxal synthase
K4A85_03880	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K4A85_03885	COG1694	Mazg nucleotide pyrophosphohydrolase
K4A85_03890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4A85_03900	COG4347	Protein of unknown function (DUF1405)
K4A85_03905	COG2010	Cytochrome c
K4A85_03905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K4A85_03910	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K4A85_03915	COG0723	plastoquinol--plastocyanin reductase activity
K4A85_03925	COG5582	Belongs to the UPF0302 family
K4A85_03930	COG0457	Tetratricopeptide repeat
K4A85_03935	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K4A85_03940	COG0287	Prephenate dehydrogenase
K4A85_03945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K4A85_03950	COG0159	tryptophan synthase activity
K4A85_03955	COG0133	tryptophan synthase activity
K4A85_03960	COG0135	phosphoribosylanthranilate isomerase activity
K4A85_03965	COG0134	indole-3-glycerol-phosphate synthase activity
K4A85_03970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K4A85_03980	COG4401	Chorismate mutase type I
K4A85_03985	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K4A85_03990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K4A85_03995	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K4A85_04000	COG0105	UTP biosynthetic process
K4A85_04005	COG0142	geranyltranstransferase activity
K4A85_04010	COG2226	methyltransferase
K4A85_04015	COG0142	geranyltranstransferase activity
K4A85_04025	COG0302	gtp cyclohydrolase
K4A85_04030	COG0776	regulation of translation
K4A85_04035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K4A85_04050	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K4A85_04055	COG1160	GTP binding
K4A85_04080	COG1304	FMN binding
K4A85_04085	COG0539	negative regulation of cytoplasmic translation
K4A85_04090	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K4A85_04100	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K4A85_04105	COG2959	enzyme of heme biosynthesis
K4A85_04110	COG3409	Peptidoglycan-binding domain 1 protein
K4A85_04110	COG3773	Cell wall hydrolase
K4A85_04115	COG2339	peptidase activity
K4A85_04120	COG0492	ferredoxin-NADP+ reductase activity
K4A85_04125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K4A85_04130	COG4862	establishment of competence for transformation
K4A85_04135	COG1408	metallophosphoesterase
K4A85_04145	COG1388	LysM domain
K4A85_04150	COG1266	CAAX protease self-immunity
K4A85_04155	COG0514	ATP-dependent DNA helicase (RecQ)
K4A85_04160	COG4955	Helix-turn-helix domain
K4A85_04165	COG1141	Ferredoxin
K4A85_04175	COG5632	N-Acetylmuramoyl-L-alanine amidase
K4A85_04175	COG3409	Peptidoglycan-binding domain 1 protein
K4A85_04185	COG1595	DNA-templated transcription, initiation
K4A85_04190	COG5002	protein histidine kinase activity
K4A85_04195	COG0745	RESPONSE REGULATOR receiver
K4A85_04200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K4A85_04205	COG1333	cytochrome c biogenesis protein
K4A85_04210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_04215	COG1187	pseudouridine synthase activity
K4A85_04220	COG0700	Nucleoside recognition
K4A85_04225	COG2715	membrane protein required for spore maturation
K4A85_04230	COG1686	Belongs to the peptidase S11 family
K4A85_04240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K4A85_04245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K4A85_04255	COG1547	Domain of unknown function (DUF309)
K4A85_04260	COG0456	acetyltransferase
K4A85_04265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K4A85_04270	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A85_04270	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A85_04275	COG0307	riboflavin synthase, alpha
K4A85_04295	COG2814	Major facilitator Superfamily
K4A85_04300	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K4A85_04305	COG4086	secreted protein
K4A85_04310	COG0019	diaminopimelate decarboxylase activity
K4A85_04315	COG0697	spore germination
K4A85_04330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4A85_04350	COG1191	sigma factor activity
K4A85_04355	COG2172	sigma factor antagonist activity
K4A85_04365	COG1686	Belongs to the peptidase S11 family
K4A85_04370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K4A85_04375	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K4A85_04380	COG4974	Belongs to the 'phage' integrase family
K4A85_04390	COG0735	belongs to the Fur family
K4A85_04395	COG1300	Membrane
K4A85_04400	COG1404	Belongs to the peptidase S8 family
K4A85_04410	COG2153	protein acetylation
K4A85_04415	COG1379	DNA repair
K4A85_04420	COG0494	nUDIX hydrolase
K4A85_04425	COG0667	Aldo Keto reductase
K4A85_04455	COG4918	Iron-sulphur cluster biosynthesis
K4A85_04460	COG4305	rare lipoprotein A
K4A85_04465	COG0456	acetyltransferase
K4A85_04465	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K4A85_04470	COG0456	acetyltransferase
K4A85_04480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K4A85_04490	COG2211	Major facilitator Superfamily
K4A85_04495	COG1072	(Pantothenic acid kinase))
K4A85_04500	COG0446	pyridine nucleotide-disulphide oxidoreductase
K4A85_04505	COG0300	oxidoreductase activity
K4A85_04510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A85_04515	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4A85_04525	COG4187	Peptidase family M20/M25/M40
K4A85_04530	COG1902	pentaerythritol trinitrate reductase activity
K4A85_04535	COG0596	Alpha beta hydrolase
K4A85_04540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4A85_04545	COG1234	tRNA 3'-trailer cleavage
K4A85_04550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K4A85_04555	COG2188	Transcriptional regulator
K4A85_04560	COG2723	6-phospho-beta-galactosidase activity
K4A85_04565	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4A85_04570	COG1447	Phosphotransferase system cellobiose-specific component IIA
K4A85_04575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4A85_04580	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_04590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K4A85_04595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K4A85_04645	COG1126	abc transporter atp-binding protein
K4A85_04650	COG0765	amino acid transport
K4A85_04655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_04665	COG1597	lipid kinase activity
K4A85_04675	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_04680	COG0022	dehydrogenase e1 component
K4A85_04685	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4A85_04690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A85_04695	COG3426	butyrate kinase activity
K4A85_04700	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K4A85_04705	COG0280	phosphate acetyltransferase
K4A85_04710	COG3290	protein histidine kinase activity
K4A85_04710	COG3829	transcription factor binding
K4A85_04720	COG0584	glycerophosphoryl diester phosphodiesterase
K4A85_04725	COG0457	Tetratricopeptide repeat
K4A85_04730	COG0745	RESPONSE REGULATOR receiver
K4A85_04735	COG0750	zinc metalloprotease
K4A85_04740	COG0497	DNA recombination
K4A85_04745	COG1438	arginine binding
K4A85_04750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K4A85_04755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K4A85_04760	COG0142	geranyltranstransferase activity
K4A85_04765	COG1722	exodeoxyribonuclease VII activity
K4A85_04770	COG1570	exodeoxyribonuclease VII activity
K4A85_04775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K4A85_04780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K4A85_04785	COG1302	Protein conserved in bacteria
K4A85_04790	COG0439	Biotin carboxylase
K4A85_04795	COG0511	ligase activity, forming carbon-carbon bonds
K4A85_04835	COG3854	ATPases associated with a variety of cellular activities
K4A85_04845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K4A85_04850	COG0006	proline dipeptidase activity
K4A85_04855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K4A85_04865	COG3872	metal-dependent enzyme
K4A85_04875	COG1752	Esterase of the alpha-beta hydrolase superfamily
K4A85_04880	COG1321	iron dependent repressor
K4A85_04885	COG0095	Lipoate-protein ligase
K4A85_04890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4A85_04895	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4A85_04900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K4A85_04905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K4A85_04910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K4A85_04935	COG0681	Belongs to the peptidase S26 family
K4A85_04970	COG4970	Tfp pilus assembly protein FimT
K4A85_04975	COG4537	Required for transformation and DNA binding
K4A85_04980	COG1459	type II secretion system
K4A85_04985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K4A85_04990	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_05000	COG1393	Belongs to the ArsC family
K4A85_05010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A85_05020	COG0011	TIGRFAM Protein of
K4A85_05025	COG2814	Major facilitator Superfamily
K4A85_05030	COG2866	Carboxypeptidase
K4A85_05035	COG1368	sulfuric ester hydrolase activity
K4A85_05040	COG1940	carbohydrate kinase activity
K4A85_05045	COG4483	Protein conserved in bacteria
K4A85_05050	COG0705	Rhomboid family
K4A85_05050	COG0457	Tetratricopeptide repeat
K4A85_05060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K4A85_05065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K4A85_05075	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K4A85_05080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4A85_05085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K4A85_05090	COG0581	inorganic phosphate transmembrane transporter activity
K4A85_05095	COG0573	inorganic phosphate transmembrane transporter activity
K4A85_05100	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K4A85_05105	COG0768	penicillin binding
K4A85_05110	COG0477	Major facilitator Superfamily
K4A85_05115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K4A85_05120	COG2839	Protein conserved in bacteria
K4A85_05125	COG5521	maltodextrose utilization protein MalA
K4A85_05130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4A85_05135	COG1388	LysM domain
K4A85_05140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K4A85_05155	COG0735	belongs to the Fur family
K4A85_05160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K4A85_05165	COG1121	(ABC) transporter
K4A85_05170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4A85_05180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K4A85_05185	COG0513	Belongs to the DEAD box helicase family
K4A85_05195	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K4A85_05200	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K4A85_05220	COG0358	DNA primase activity
K4A85_05225	COG1671	Belongs to the UPF0178 family
K4A85_05235	COG0517	IMP dehydrogenase activity
K4A85_05240	COG0751	glycine-tRNA ligase activity
K4A85_05245	COG0752	glycyl-tRNA synthetase alpha subunit
K4A85_05250	COG1381	Involved in DNA repair and RecF pathway recombination
K4A85_05260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K4A85_05265	COG0295	cytidine deaminase activity
K4A85_05270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K4A85_05275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K4A85_05280	COG1480	7TM receptor with intracellular HD hydrolase
K4A85_05285	COG1702	phosphate starvation-inducible protein PhoH
K4A85_05290	COG0561	phosphatase activity
K4A85_05305	COG4864	UPF0365 protein
K4A85_05310	COG1030	water channel activity
K4A85_05315	COG1610	YqeY-like protein
K4A85_05325	COG1283	sodium-dependent phosphate transmembrane transporter activity
K4A85_05330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K4A85_05335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K4A85_05340	COG2264	protein methyltransferase activity
K4A85_05345	COG0484	heat shock protein binding
K4A85_05350	COG0443	Heat shock 70 kDa protein
K4A85_05355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K4A85_05360	COG1420	regulation of RNA biosynthetic process
K4A85_05365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K4A85_05370	COG0481	GTPase activity
K4A85_05380	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A85_05385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K4A85_05390	COG0268	Binds directly to 16S ribosomal RNA
K4A85_05395	COG1466	dna polymerase III delta subunit
K4A85_05405	COG0658	competence protein
K4A85_05405	COG2333	competence protein COMEC
K4A85_05410	COG2131	deaminase
K4A85_05415	COG1555	photosystem II stabilization
K4A85_05420	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K4A85_05425	COG2226	methyltransferase
K4A85_05430	COG0799	negative regulation of ribosome biogenesis
K4A85_05435	COG1713	HD superfamily hydrolase involved in NAD metabolism
K4A85_05440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K4A85_05445	COG1534	Rna-binding protein
K4A85_05450	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K4A85_05455	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K4A85_05460	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K4A85_05475	COG2755	lipolytic protein G-D-S-L family
K4A85_05485	COG0457	Tetratricopeptide repeat
K4A85_05500	COG4221	oxidoreductase activity
K4A85_05505	COG0300	oxidoreductase activity
K4A85_05510	COG1902	pentaerythritol trinitrate reductase activity
K4A85_05515	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_05515	COG0596	Alpha beta hydrolase
K4A85_05520	COG1309	transcriptional regulator
K4A85_05530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4A85_05545	COG0726	polysaccharide deacetylase
K4A85_05580	COG1122	ATPase activity
K4A85_05600	COG2160	L-arabinose isomerase activity
K4A85_05615	COG1609	Transcriptional regulator
K4A85_05630	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A85_05630	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_05630	COG3321	synthase
K4A85_05630	COG4221	oxidoreductase activity
K4A85_05695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A85_05705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A85_05745	COG0657	acetylesterase activity
K4A85_05765	COG2602	Beta-lactamase
K4A85_05770	COG1960	acyl-CoA dehydrogenase activity
K4A85_05775	COG1126	abc transporter atp-binding protein
K4A85_05780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_05785	COG0765	amino acid transport
K4A85_05795	COG3546	catalase activity
K4A85_05800	COG1063	alcohol dehydrogenase
K4A85_05810	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_05815	COG0842	Transport permease protein
K4A85_05820	COG1511	domain protein
K4A85_05820	COG0842	Transport permease protein
K4A85_05825	COG1131	(ABC) transporter
K4A85_05830	COG1063	alcohol dehydrogenase
K4A85_05835	COG2226	methyltransferase
K4A85_05860	COG0626	cystathionine gamma-synthase activity
K4A85_05865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K4A85_05870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K4A85_05875	COG2226	methyltransferase
K4A85_05890	COG0768	penicillin binding
K4A85_05895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K4A85_05900	COG0572	uridine kinase
K4A85_05905	COG0826	peptidase U32
K4A85_05910	COG0826	peptidase U32
K4A85_05915	COG4122	O-methyltransferase activity
K4A85_05920	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K4A85_05925	COG0183	Belongs to the thiolase family
K4A85_05930	COG0318	PFAM AMP-dependent synthetase and ligase
K4A85_05935	COG1268	BioY protein
K4A85_05940	COG3906	Belongs to the UPF0473 family
K4A85_05945	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K4A85_05950	COG4472	Bacterial protein of unknown function (DUF965)
K4A85_05955	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K4A85_05960	COG0628	permease
K4A85_05965	COG1126	abc transporter atp-binding protein
K4A85_05970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_05975	COG0765	amino acid transport
K4A85_05980	COG0765	amino acid transport
K4A85_05995	COG3881	PFAM PRC-barrel domain
K4A85_06000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K4A85_06005	COG0457	Tetratricopeptide repeat
K4A85_06010	COG0482	sulfurtransferase activity
K4A85_06015	COG1104	cysteine desulfurase activity
K4A85_06020	COG1959	2 iron, 2 sulfur cluster binding
K4A85_06025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K4A85_06030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K4A85_06045	COG0124	histidyl-tRNA synthetase
K4A85_06055	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A85_06055	COG3103	Sh3 type 3 domain protein
K4A85_06055	COG4991	sh3 domain protein
K4A85_06060	COG1490	D-aminoacyl-tRNA deacylase activity
K4A85_06065	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K4A85_06070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4A85_06075	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K4A85_06075	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K4A85_06080	COG5416	Lipopolysaccharide assembly protein A domain
K4A85_06085	COG0490	domain, Protein
K4A85_06090	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4A85_06090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K4A85_06100	COG2244	polysaccharide biosynthetic process
K4A85_06105	COG2323	membrane
K4A85_06115	COG1862	Preprotein translocase
K4A85_06120	COG0343	queuine tRNA-ribosyltransferase activity
K4A85_06125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K4A85_06150	COG2112	serine threonine protein kinase
K4A85_06165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K4A85_06180	COG1388	LysM domain
K4A85_06180	COG1388	LysM domain
K4A85_06185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K4A85_06190	COG0157	Belongs to the NadC ModD family
K4A85_06195	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K4A85_06200	COG1104	cysteine desulfurase activity
K4A85_06205	COG1827	regulation of RNA biosynthetic process
K4A85_06210	COG0077	Prephenate dehydratase
K4A85_06215	COG4492	Belongs to the UPF0735 family
K4A85_06220	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K4A85_06225	COG3290	protein histidine kinase activity
K4A85_06230	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K4A85_06235	COG2868	ribosomal protein
K4A85_06240	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K4A85_06245	COG1994	Peptidase M50
K4A85_06250	COG0739	heme binding
K4A85_06255	COG2894	cell division
K4A85_06260	COG0850	regulation of cytokinetic process
K4A85_06265	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K4A85_06275	COG1077	Cell shape determining protein MreB Mrl
K4A85_06280	COG2003	Belongs to the UPF0758 family
K4A85_06285	COG0424	maF-like protein
K4A85_06300	COG0285	dihydrofolate synthase activity
K4A85_06305	COG0525	valine-tRNA ligase activity
K4A85_06315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4A85_06320	COG1388	LysM domain
K4A85_06325	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K4A85_06330	COG0113	porphobilinogen synthase activity
K4A85_06335	COG1587	Uroporphyrinogen-III synthase
K4A85_06340	COG0181	hydroxymethylbilane synthase activity
K4A85_06345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K4A85_06350	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K4A85_06360	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K4A85_06365	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K4A85_06370	COG0470	DNA polymerase III
K4A85_06370	COG1067	ATP-dependent peptidase activity
K4A85_06375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K4A85_06380	COG0544	peptidyl-prolyl cis-trans isomerase activity
K4A85_06385	COG0457	Tetratricopeptide repeat
K4A85_06385	COG1477	protein flavinylation
K4A85_06390	COG0066	3-isopropylmalate dehydratase activity
K4A85_06395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K4A85_06400	COG0473	3-isopropylmalate dehydrogenase activity
K4A85_06405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4A85_06410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K4A85_06415	COG0440	acetolactate synthase activity
K4A85_06420	COG0028	Belongs to the TPP enzyme family
K4A85_06425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4A85_06430	COG2706	6-phosphogluconolactonase activity
K4A85_06435	COG3339	Conserved Protein
K4A85_06440	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K4A85_06445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K4A85_06450	COG1696	Membrane protein involved in D-alanine export
K4A85_06455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A85_06500	COG0622	Phosphoesterase
K4A85_06505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K4A85_06510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K4A85_06515	COG5401	PFAM Sporulation and spore germination
K4A85_06520	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K4A85_06525	COG1846	Transcriptional regulator
K4A85_06530	COG2197	response regulator
K4A85_06535	COG2851	Citrate transporter
K4A85_06540	COG0583	DNA-binding transcription factor activity
K4A85_06545	COG2828	Protein conserved in bacteria
K4A85_06565	COG0824	Thioesterase
K4A85_06570	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K4A85_06575	COG1053	succinate dehydrogenase
K4A85_06580	COG2009	succinate dehydrogenase
K4A85_06585	COG1719	4-vinyl reductase, 4VR
K4A85_06590	COG0527	aspartate kinase activity
K4A85_06595	COG0322	excinuclease ABC activity
K4A85_06600	COG3118	belongs to the thioredoxin family
K4A85_06605	COG3534	alpha-L-arabinofuranosidase
K4A85_06610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K4A85_06615	COG2086	electron transfer activity
K4A85_06620	COG1024	Enoyl-CoA hydratase
K4A85_06625	COG1309	transcriptional regulator
K4A85_06630	COG0318	PFAM AMP-dependent synthetase and ligase
K4A85_06640	COG3766	membrane
K4A85_06645	COG1193	negative regulation of DNA recombination
K4A85_06650	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K4A85_06650	COG1796	DNA polymerase
K4A85_06655	COG1286	toxin biosynthetic process
K4A85_06660	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K4A85_06665	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K4A85_06670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A85_06670	COG0072	phenylalanine-tRNA ligase activity
K4A85_06675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K4A85_06680	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4A85_06690	COG1966	Carbon starvation protein
K4A85_06695	COG1363	Peptidase, m42
K4A85_06705	COG3326	Membrane
K4A85_06710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K4A85_06715	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K4A85_06720	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K4A85_06725	COG1346	cytolysis
K4A85_06735	COG3279	Response regulator of the LytR AlgR family
K4A85_06740	COG3275	phosphorelay sensor kinase activity
K4A85_06745	COG1011	Hydrolase
K4A85_06755	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4A85_06765	COG0398	Pfam SNARE associated Golgi protein
K4A85_06770	COG1484	DNA-dependent DNA replication
K4A85_06775	COG3611	Membrane attachment protein
K4A85_06780	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K4A85_06790	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K4A85_06795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K4A85_06800	COG0237	dephospho-CoA kinase activity
K4A85_06805	COG1971	Probably functions as a manganese efflux pump
K4A85_06810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K4A85_06815	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A85_06815	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K4A85_06820	COG5002	protein histidine kinase activity
K4A85_06825	COG0745	RESPONSE REGULATOR receiver
K4A85_06830	COG0039	L-malate dehydrogenase activity
K4A85_06835	COG0538	isocitrate dehydrogenase activity
K4A85_06840	COG0372	Belongs to the citrate synthase family
K4A85_06845	COG2707	UPF0756 membrane protein
K4A85_06850	COG0628	permease
K4A85_06855	COG3030	protein affecting phage T7 exclusion by the F plasmid
K4A85_06865	COG0205	6-phosphofructokinase activity
K4A85_06870	COG0825	malonyl-CoA metabolic process
K4A85_06875	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K4A85_06880	COG0281	malic enzyme
K4A85_06885	COG0587	DNA-directed DNA polymerase activity
K4A85_06905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K4A85_06915	COG4109	DRTGG domain
K4A85_06920	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K4A85_06925	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_06930	COG0165	Argininosuccinate lyase
K4A85_06935	COG0137	argininosuccinate synthase activity
K4A85_06940	COG0521	Mo-molybdopterin cofactor biosynthetic process
K4A85_06945	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K4A85_06950	COG0827	DNA restriction-modification system
K4A85_06955	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K4A85_06960	COG3874	Sporulation protein YtfJ
K4A85_06970	COG1714	RDD family
K4A85_06975	COG0616	signal peptide processing
K4A85_06980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K4A85_06990	COG3239	Fatty acid desaturase
K4A85_06995	COG4585	Histidine kinase
K4A85_07000	COG2197	response regulator
K4A85_07005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_07010	COG0745	RESPONSE REGULATOR receiver
K4A85_07015	COG2205	protein histidine kinase activity
K4A85_07020	COG0772	Belongs to the SEDS family
K4A85_07025	COG1695	Transcriptional regulator
K4A85_07030	COG1136	(ABC) transporter
K4A85_07035	COG0577	efflux transmembrane transporter activity
K4A85_07040	COG0402	S-adenosylhomocysteine deaminase activity
K4A85_07045	COG2249	NAD(P)H dehydrogenase (quinone) activity
K4A85_07055	COG1279	arginine transmembrane transporter activity
K4A85_07060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K4A85_07070	COG0301	tRNA thio-modification
K4A85_07075	COG1104	cysteine desulfurase activity
K4A85_07080	COG1114	Component of the transport system for branched-chain amino acids
K4A85_07085	COG1114	Component of the transport system for branched-chain amino acids
K4A85_07090	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K4A85_07095	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K4A85_07100	COG1309	transcriptional regulator
K4A85_07105	COG1956	GAF domain-containing protein
K4A85_07110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K4A85_07130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K4A85_07135	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K4A85_07140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K4A85_07145	COG0454	-acetyltransferase
K4A85_07150	COG0517	IMP dehydrogenase activity
K4A85_07155	COG0123	including yeast histone deacetylase and acetoin utilization protein
K4A85_07190	COG1674	ftsk spoiiie
K4A85_07195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A85_07200	COG4848	Belongs to the UPF0354 family
K4A85_07205	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_07220	COG1363	Peptidase, m42
K4A85_07225	COG5584	Small secreted protein
K4A85_07230	COG0281	malic enzyme
K4A85_07235	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A85_07240	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K4A85_07270	COG3340	Belongs to the peptidase S51 family
K4A85_07280	COG2252	PERMEase
K4A85_07285	COG1349	DNA-binding transcription factor activity
K4A85_07290	COG1187	pseudouridine synthase activity
K4A85_07295	COG2244	polysaccharide biosynthetic process
K4A85_07315	COG3196	Protein conserved in bacteria
K4A85_07325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4A85_07330	COG5578	integral membrane protein
K4A85_07335	COG0673	inositol 2-dehydrogenase activity
K4A85_07340	COG1653	transport
K4A85_07345	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K4A85_07350	COG4209	transmembrane transport
K4A85_07355	COG2207	Transcriptional regulator
K4A85_07360	COG1733	regulation of RNA biosynthetic process
K4A85_07365	COG2814	Major facilitator Superfamily
K4A85_07370	COG0656	L-ascorbic acid biosynthetic process
K4A85_07375	COG1653	transport
K4A85_07380	COG0395	ABC-type sugar transport system, permease component
K4A85_07385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A85_07390	COG1073	alpha beta
K4A85_07395	COG0495	leucyl-tRNA aminoacylation
K4A85_07405	COG2202	Pas domain
K4A85_07405	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_07410	COG2433	Pfam Transposase IS66
K4A85_07415	COG0577	efflux transmembrane transporter activity
K4A85_07420	COG1136	(ABC) transporter
K4A85_07430	COG1131	(ABC) transporter
K4A85_07435	COG1725	Transcriptional regulator
K4A85_07450	COG1242	4 iron, 4 sulfur cluster binding
K4A85_07455	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K4A85_07465	COG2267	carboxylic ester hydrolase activity
K4A85_07470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K4A85_07475	COG0367	asparagine synthase
K4A85_07485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K4A85_07495	COG1506	peptidase
K4A85_07500	COG1233	COG1233 Phytoene dehydrogenase and related
K4A85_07520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K4A85_07525	COG1116	anion transmembrane transporter activity
K4A85_07530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K4A85_07535	COG0494	nUDIX hydrolase
K4A85_07540	COG2310	stress, protein
K4A85_07560	COG0783	Belongs to the Dps family
K4A85_07575	COG1854	S-ribosylhomocysteine lyase activity
K4A85_07580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K4A85_07585	COG0288	reversible hydration of carbon dioxide
K4A85_07590	COG3443	Belongs to the bacterial solute-binding protein 9 family
K4A85_07590	COG0803	Belongs to the bacterial solute-binding protein 9 family
K4A85_07595	COG0254	rRNA binding
K4A85_07600	COG1271	oxidase subunit
K4A85_07605	COG1294	oxidase, subunit
K4A85_07620	COG4948	Mandelate Racemase Muconate Lactonizing
K4A85_07625	COG0318	PFAM AMP-dependent synthetase and ligase
K4A85_07630	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K4A85_07635	COG0596	Alpha beta hydrolase
K4A85_07640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K4A85_07645	COG1169	isochorismate synthase
K4A85_07650	COG1575	Belongs to the MenA family. Type 1 subfamily
K4A85_07655	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K4A85_07785	COG3859	Proton-coupled thiamine transporter YuaJ
K4A85_07800	COG1585	Membrane protein implicated in regulation of membrane protease activity
K4A85_07805	COG2318	DinB family
K4A85_07810	COG1454	alcohol dehydrogenase
K4A85_07815	COG1012	belongs to the aldehyde dehydrogenase family
K4A85_07820	COG1510	regulation of RNA biosynthetic process
K4A85_07835	COG3409	Peptidoglycan-binding domain 1 protein
K4A85_07835	COG5632	N-Acetylmuramoyl-L-alanine amidase
K4A85_07885	COG3778	Protein conserved in bacteria
K4A85_07890	COG3299	homolog of phage Mu protein gp47
K4A85_07895	COG3628	GPW Gp25 family protein
K4A85_07980	COG5518	Phage portal protein
K4A85_07985	COG1783	phage Terminase large subunit
K4A85_07990	COG5484	DNA packaging
K4A85_07995	COG1595	DNA-templated transcription, initiation
K4A85_08005	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K4A85_08025	COG1396	sequence-specific DNA binding
K4A85_08035	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K4A85_08045	COG1968	undecaprenyl-diphosphatase activity
K4A85_08050	COG0628	permease
K4A85_08060	COG0673	inositol 2-dehydrogenase activity
K4A85_08075	COG0840	transmembrane signaling receptor activity
K4A85_08080	COG0840	transmembrane signaling receptor activity
K4A85_08085	COG0840	transmembrane signaling receptor activity
K4A85_08100	COG0432	Pfam Uncharacterised protein family UPF0047
K4A85_08105	COG1253	flavin adenine dinucleotide binding
K4A85_08110	COG2738	Putative neutral zinc metallopeptidase
K4A85_08120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K4A85_08135	COG0166	Belongs to the GPI family
K4A85_08140	COG1979	alcohol dehydrogenase
K4A85_08145	COG1979	alcohol dehydrogenase
K4A85_08150	COG2155	Conserved Protein
K4A85_08155	COG1098	S1 RNA binding domain
K4A85_08160	COG0436	Aminotransferase
K4A85_08165	COG1522	sequence-specific DNA binding
K4A85_08170	COG2267	carboxylic ester hydrolase activity
K4A85_08180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K4A85_08185	COG2205	protein histidine kinase activity
K4A85_08200	COG5018	Exonuclease
K4A85_08205	COG2814	Major facilitator Superfamily
K4A85_08210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A85_08215	COG3011	Protein conserved in bacteria
K4A85_08225	COG3290	protein histidine kinase activity
K4A85_08230	COG4565	transcriptional regulatory protein
K4A85_08235	COG1744	ABC transporter substrate-binding protein PnrA-like
K4A85_08240	COG3845	ABC transporter
K4A85_08245	COG4603	Belongs to the binding-protein-dependent transport system permease family
K4A85_08250	COG1079	Belongs to the binding-protein-dependent transport system permease family
K4A85_08255	COG3493	citrate carrier protein
K4A85_08265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K4A85_08265	COG2111	Na H antiporter
K4A85_08270	COG2111	Na H antiporter
K4A85_08275	COG1006	Multisubunit Na H antiporter MnhC subunit
K4A85_08280	COG0651	ATP synthesis coupled electron transport
K4A85_08285	COG1863	multisubunit Na H antiporter MnhE subunit
K4A85_08290	COG2212	antiporter activity
K4A85_08295	COG1320	monovalent cation:proton antiporter activity
K4A85_08300	COG2050	protein possibly involved in aromatic compounds catabolism
K4A85_08305	COG2197	response regulator
K4A85_08310	COG4585	Histidine kinase
K4A85_08320	COG0142	geranyltranstransferase activity
K4A85_08335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K4A85_08340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K4A85_08345	COG1335	isochorismatase
K4A85_08350	COG5506	Protein of unknown function (DUF1694)
K4A85_08370	COG0628	permease
K4A85_08385	COG1418	mRNA catabolic process
K4A85_08390	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_08400	COG1511	domain protein
K4A85_08405	COG1674	ftsk spoiiie
K4A85_08405	COG0433	COG0433 Predicted ATPase
K4A85_08410	COG4499	WXG100 protein secretion system (Wss), protein YukC
K4A85_08415	COG5417	Belongs to the EsaB family
K4A85_08420	COG4842	Belongs to the WXG100 family
K4A85_08425	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K4A85_08425	COG2508	Transcriptional regulator
K4A85_08435	COG1268	BioY protein
K4A85_08440	COG4326	sporulation control protein
K4A85_08445	COG2056	Na+-H+ antiporter family
K4A85_08450	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K4A85_08455	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K4A85_08460	COG3584	3D domain protein
K4A85_08475	COG1252	NADH dehydrogenase
K4A85_08480	COG0492	ferredoxin-NADP+ reductase activity
K4A85_08490	COG0789	Transcriptional regulator
K4A85_08495	COG5504	Zn-dependent protease
K4A85_08500	COG0316	Belongs to the HesB IscA family
K4A85_08505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K4A85_08510	COG4844	belongs to the
K4A85_08515	COG1252	NADH dehydrogenase
K4A85_08525	COG4837	Protein of unknown function (DUF1462)
K4A85_08530	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K4A85_08535	COG0823	Involved in the tonB-independent uptake of proteins
K4A85_08535	COG1506	peptidase
K4A85_08535	COG4946	Tricorn protease homolog
K4A85_08540	COG0083	homoserine kinase activity
K4A85_08545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K4A85_08550	COG0460	homoserine dehydrogenase
K4A85_08555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K4A85_08560	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4A85_08565	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K4A85_08570	COG0647	UMP catabolic process
K4A85_08575	COG2445	Protein of unknown function DUF86
K4A85_08580	COG4470	Protein conserved in bacteria
K4A85_08590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K4A85_08595	COG0739	heme binding
K4A85_08605	COG3377	Domain of unknown function (DUF1805)
K4A85_08610	COG0737	Belongs to the 5'-nucleotidase family
K4A85_08615	COG1801	Protein of unknown function DUF72
K4A85_08620	COG2508	Transcriptional regulator
K4A85_08625	COG2814	Major facilitator Superfamily
K4A85_08630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K4A85_08635	COG2356	endonuclease I
K4A85_08645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4A85_08650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4A85_08655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_08665	COG0642	Histidine kinase
K4A85_08665	COG5002	protein histidine kinase activity
K4A85_08670	COG0745	RESPONSE REGULATOR receiver
K4A85_08675	COG2311	Membrane
K4A85_08685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K4A85_08705	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
K4A85_08715	COG0719	Fe-S assembly protein
K4A85_08720	COG0822	iron-sulfur transferase activity
K4A85_08725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K4A85_08730	COG0719	Fe-S assembly protein
K4A85_08745	COG1464	Belongs to the NlpA lipoprotein family
K4A85_08750	COG2011	ABC-type metal ion transport system permease component
K4A85_08755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K4A85_08770	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K4A85_08780	COG0509	glycine decarboxylation via glycine cleavage system
K4A85_08785	COG1393	Belongs to the ArsC family
K4A85_08790	COG1960	acyl-CoA dehydrogenase activity
K4A85_08795	COG0183	Belongs to the thiolase family
K4A85_08800	COG1024	Enoyl-CoA hydratase
K4A85_08800	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A85_08815	COG5577	PFAM Coat F domain
K4A85_08825	COG1120	ATPase activity
K4A85_08835	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_08840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A85_08845	COG0745	RESPONSE REGULATOR receiver
K4A85_08850	COG2205	protein histidine kinase activity
K4A85_08850	COG2770	Histidine kinase
K4A85_08860	COG1309	transcriptional regulator
K4A85_08865	COG0114	fumarate hydratase activity
K4A85_08875	COG0697	spore germination
K4A85_08880	COG0814	amino acid
K4A85_08895	COG2197	response regulator
K4A85_08900	COG4585	Histidine kinase
K4A85_08905	COG4758	membrane
K4A85_08930	COG1120	ATPase activity
K4A85_08935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4A85_08940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_08950	COG2721	sulfolactate sulfo-lyase activity
K4A85_08955	COG0246	Mannitol dehydrogenase
K4A85_08960	COG1609	Transcriptional regulator
K4A85_08965	COG1904	glucuronate isomerase
K4A85_08970	COG2205	protein histidine kinase activity
K4A85_08975	COG0745	RESPONSE REGULATOR receiver
K4A85_09000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_09005	COG0531	amino acid
K4A85_09020	COG1988	membrane-bound metal-dependent
K4A85_09025	COG1368	sulfuric ester hydrolase activity
K4A85_09030	COG0725	ABC transporter, periplasmic molybdate-binding protein
K4A85_09035	COG4149	molybdate abc transporter
K4A85_09040	COG0656	L-ascorbic acid biosynthetic process
K4A85_09045	COG1940	carbohydrate kinase activity
K4A85_09050	COG0025	NhaP-type Na H and K H
K4A85_09055	COG2860	membrane
K4A85_09060	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K4A85_09065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K4A85_09070	COG2217	Heavy metal translocating P-type atpase
K4A85_09075	COG1121	(ABC) transporter
K4A85_09080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K4A85_09085	COG0803	Belongs to the bacterial solute-binding protein 9 family
K4A85_09095	COG3226	Transcriptional regulator
K4A85_09100	COG0784	Response regulator, receiver
K4A85_09105	COG4191	Histidine kinase
K4A85_09110	COG1027	Aspartate ammonia-lyase
K4A85_09125	COG2217	Heavy metal translocating P-type atpase
K4A85_09130	COG2608	mercury ion transmembrane transporter activity
K4A85_09135	COG1937	Protein conserved in bacteria
K4A85_09150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K4A85_09165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K4A85_09170	COG0557	exoribonuclease II activity
K4A85_09175	COG1647	Serine aminopeptidase, S33
K4A85_09180	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K4A85_09185	COG2002	toxin-antitoxin pair type II binding
K4A85_09190	COG1476	TRANSCRIPTIONal
K4A85_09195	COG1396	sequence-specific DNA binding
K4A85_09200	COG1396	sequence-specific DNA binding
K4A85_09245	COG0456	acetyltransferase
K4A85_09265	COG1131	(ABC) transporter
K4A85_09280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K4A85_09285	COG0149	triose-phosphate isomerase activity
K4A85_09290	COG0126	phosphoglycerate kinase activity
K4A85_09295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K4A85_09300	COG2390	Transcriptional regulator
K4A85_09305	COG0833	amino acid
K4A85_09310	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K4A85_09315	COG3829	transcription factor binding
K4A85_09320	COG2186	Transcriptional regulator
K4A85_09325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K4A85_09335	COG0534	Mate efflux family protein
K4A85_09340	COG4608	Belongs to the ABC transporter superfamily
K4A85_09345	COG0444	Belongs to the ABC transporter superfamily
K4A85_09350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4A85_09355	COG0601	transmembrane transport
K4A85_09360	COG0747	negative chemotaxis
K4A85_09365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K4A85_09370	COG0110	maltose O-acetyltransferase activity
K4A85_09375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K4A85_09380	COG2244	polysaccharide biosynthetic process
K4A85_09390	COG1216	Glycosyl transferase, family 2
K4A85_09400	COG0438	transferase activity, transferring glycosyl groups
K4A85_09405	COG1215	transferase activity, transferring glycosyl groups
K4A85_09410	COG0438	transferase activity, transferring glycosyl groups
K4A85_09415	COG1086	Polysaccharide biosynthesis protein
K4A85_09420	COG0489	protein tyrosine kinase activity
K4A85_09425	COG3944	biosynthesis protein
K4A85_09430	COG1396	sequence-specific DNA binding
K4A85_09455	COG0726	polysaccharide deacetylase
K4A85_09460	COG0488	(ABC) transporter
K4A85_09465	COG1124	(ABC) transporter
K4A85_09480	COG0601	transmembrane transport
K4A85_09485	COG0747	negative chemotaxis
K4A85_09490	COG1819	glycosyl
K4A85_09495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_09505	COG0740	serine-type endopeptidase activity
K4A85_09510	COG1611	Belongs to the LOG family
K4A85_09515	COG1694	Mazg nucleotide pyrophosphohydrolase
K4A85_09520	COG0659	secondary active sulfate transmembrane transporter activity
K4A85_09525	COG0288	reversible hydration of carbon dioxide
K4A85_09540	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K4A85_09545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_09550	COG1481	regulation of sporulation
K4A85_09555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K4A85_09560	COG1660	Displays ATPase and GTPase activities
K4A85_09565	COG1051	belongs to the nudix hydrolase family
K4A85_09585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K4A85_09585	COG0140	phosphoribosyl-ATP diphosphatase activity
K4A85_09590	COG0107	imidazoleglycerol-phosphate synthase activity
K4A85_09595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K4A85_09600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K4A85_09605	COG0131	Imidazoleglycerol-phosphate dehydratase
K4A85_09610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K4A85_09615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K4A85_09620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K4A85_09625	COG4990	cell redox homeostasis
K4A85_09630	COG2910	NAD(P)H-binding
K4A85_09635	COG1959	2 iron, 2 sulfur cluster binding
K4A85_09640	COG0110	maltose O-acetyltransferase activity
K4A85_09645	COG0546	phosphoglycolate phosphatase activity
K4A85_09650	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K4A85_09660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K4A85_09665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K4A85_09670	COG0363	glucosamine-6-phosphate deaminase activity
K4A85_09675	COG2188	Transcriptional regulator
K4A85_09680	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K4A85_09685	COG1950	PFAM Membrane protein of
K4A85_09690	COG1983	PspC domain protein
K4A85_09695	COG3595	metallopeptidase activity
K4A85_09710	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K4A85_09720	COG4897	Protein conserved in bacteria
K4A85_09725	COG0574	Belongs to the PEP-utilizing enzyme family
K4A85_09725	COG3848	Pyruvate phosphate dikinase
K4A85_09730	COG1309	transcriptional regulator
K4A85_09735	COG2814	Major facilitator Superfamily
K4A85_09745	COG0745	RESPONSE REGULATOR receiver
K4A85_09750	COG5002	protein histidine kinase activity
K4A85_09755	COG1113	amino acid transport
K4A85_09760	COG0778	Nitroreductase
K4A85_09765	COG1733	regulation of RNA biosynthetic process
K4A85_09770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A85_09780	COG0793	Belongs to the peptidase S41A family
K4A85_09780	COG3409	Peptidoglycan-binding domain 1 protein
K4A85_09785	COG0730	response to heat
K4A85_09790	COG0791	NLP P60 protein
K4A85_09790	COG3883	PFAM NLP P60 protein
K4A85_09795	COG2177	Part of the ABC transporter FtsEX involved in
K4A85_09800	COG2884	Cell division ATP-binding protein ftsE
K4A85_09805	COG2010	Cytochrome c
K4A85_09810	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4A85_09830	COG0653	protein targeting
K4A85_09835	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K4A85_09840	COG0840	transmembrane signaling receptor activity
K4A85_09850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K4A85_09855	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K4A85_09860	COG1334	flagellar protein FlaG
K4A85_09865	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K4A85_09870	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K4A85_09880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4A85_09885	COG4786	Flagellar basal body rod
K4A85_09885	COG1256	bacterial-type flagellum assembly
K4A85_09890	COG3418	PFAM FlgN family protein
K4A85_09905	COG1040	competence protein
K4A85_09915	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K4A85_09920	COG1307	EDD domain protein, DegV family
K4A85_09930	COG4585	Histidine kinase
K4A85_09935	COG1739	Uncharacterized protein family UPF0029
K4A85_09940	COG1316	TRANSCRIPTIONal
K4A85_09945	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K4A85_09950	COG0438	transferase activity, transferring glycosyl groups
K4A85_09955	COG1215	transferase activity, transferring glycosyl groups
K4A85_09960	COG3206	protein involved in exopolysaccharide biosynthesis
K4A85_09965	COG3307	-O-antigen
K4A85_09970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A85_09975	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K4A85_09980	COG0297	glycogen (starch) synthase activity
K4A85_09980	COG0438	transferase activity, transferring glycosyl groups
K4A85_09985	COG2244	polysaccharide biosynthetic process
K4A85_10030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K4A85_10035	COG1134	teichoic acid transport
K4A85_10040	COG1682	transport, permease protein
K4A85_10050	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K4A85_10060	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K4A85_10065	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K4A85_10070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K4A85_10075	COG4193	domain, Protein
K4A85_10080	COG1482	cell wall glycoprotein biosynthetic process
K4A85_10090	COG1175	transmembrane transport
K4A85_10095	COG1653	transport
K4A85_10105	COG2972	Histidine kinase
K4A85_10115	COG0454	-acetyltransferase
K4A85_10120	COG0800	Aldolase
K4A85_10125	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A85_10130	COG1609	Transcriptional regulator
K4A85_10135	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K4A85_10140	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_10145	COG0697	spore germination
K4A85_10150	COG0814	amino acid
K4A85_10165	COG2814	Major facilitator Superfamily
K4A85_10170	COG1316	TRANSCRIPTIONal
K4A85_10175	COG0561	phosphatase activity
K4A85_10180	COG0791	NLP P60 protein
K4A85_10190	COG2843	Capsule synthesis protein
K4A85_10200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K4A85_10205	COG0697	spore germination
K4A85_10220	COG1609	Transcriptional regulator
K4A85_10225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K4A85_10230	COG1869	D-ribose catabolic process
K4A85_10235	COG1129	ABC transporter
K4A85_10240	COG1172	Belongs to the binding-protein-dependent transport system permease family
K4A85_10245	COG1879	ABC-type sugar transport system periplasmic component
K4A85_10250	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K4A85_10255	COG0583	DNA-binding transcription factor activity
K4A85_10260	COG0028	Belongs to the TPP enzyme family
K4A85_10265	COG3527	Alpha-acetolactate decarboxylase
K4A85_10270	COG1522	sequence-specific DNA binding
K4A85_10275	COG2059	Chromate
K4A85_10280	COG2059	Chromate
K4A85_10285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K4A85_10295	COG4715	Zinc finger, swim domain protein
K4A85_10300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K4A85_10305	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_10305	COG2202	Pas domain
K4A85_10310	COG0561	phosphatase activity
K4A85_10325	COG1970	mechanosensitive ion channel activity
K4A85_10330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K4A85_10335	COG0457	Tetratricopeptide repeat
K4A85_10340	COG4786	Flagellar basal body rod
K4A85_10350	COG1077	Cell shape determining protein MreB Mrl
K4A85_10355	COG1609	Transcriptional regulator
K4A85_10360	COG1846	Transcriptional regulator
K4A85_10365	COG2814	Major facilitator Superfamily
K4A85_10370	COG0671	phosphoesterase, PA-phosphatase related
K4A85_10375	COG0477	Major facilitator Superfamily
K4A85_10380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_10385	COG0765	amino acid transport
K4A85_10395	COG0004	ammonium transporteR
K4A85_10400	COG0347	Belongs to the P(II) protein family
K4A85_10405	COG0739	heme binding
K4A85_10410	COG1247	-acetyltransferase
K4A85_10445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K4A85_10450	COG0523	cobalamin synthesis protein
K4A85_10455	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K4A85_10460	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K4A85_10465	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K4A85_10475	COG0243	molybdopterin cofactor binding
K4A85_10480	COG2304	oxidoreductase activity
K4A85_10485	COG2304	oxidoreductase activity
K4A85_10490	COG2385	sporulation resulting in formation of a cellular spore
K4A85_10495	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K4A85_10505	COG4836	Membrane
K4A85_10515	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K4A85_10520	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K4A85_10525	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K4A85_10530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K4A85_10535	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K4A85_10540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K4A85_10545	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K4A85_10550	COG0356	it plays a direct role in the translocation of protons across the membrane
K4A85_10560	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K4A85_10565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K4A85_10570	COG4475	Protein of unknown function (DUF436)
K4A85_10575	COG0698	ribose 5-phosphate isomerase
K4A85_10580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4A85_10585	COG1971	Probably functions as a manganese efflux pump
K4A85_10590	COG0009	L-threonylcarbamoyladenylate synthase
K4A85_10595	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K4A85_10615	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K4A85_10625	COG0789	Transcriptional regulator
K4A85_10630	COG0679	Auxin Efflux Carrier
K4A85_10635	COG0281	malic enzyme
K4A85_10640	COG1435	thymidine kinase activity
K4A85_10645	COG0254	rRNA binding
K4A85_10650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K4A85_10655	COG1494	fructose-1,6-bisphosphatase
K4A85_10660	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K4A85_10665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K4A85_10670	COG0191	fructose-bisphosphate aldolase activity
K4A85_10675	COG2204	response regulator
K4A85_10680	COG4821	SIS domain
K4A85_10685	COG0504	CTP synthase activity
K4A85_10690	COG3343	RNA polymerase activity
K4A85_10720	COG1960	acyl-CoA dehydrogenase activity
K4A85_10725	COG1960	acyl-CoA dehydrogenase activity
K4A85_10730	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A85_10735	COG0183	Belongs to the thiolase family
K4A85_10740	COG0247	lactate metabolic process
K4A85_10740	COG2181	nitrate reductase activity
K4A85_10745	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A85_10750	COG4294	response to UV
K4A85_10760	COG1619	proteins homologs of microcin C7 resistance protein MccF
K4A85_10765	COG1132	(ABC) transporter
K4A85_10770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A85_10775	COG1619	proteins homologs of microcin C7 resistance protein MccF
K4A85_10780	COG0018	arginyl-trna synthetase
K4A85_10785	COG4506	Protein conserved in bacteria
K4A85_10795	COG0010	Belongs to the arginase family
K4A85_10800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K4A85_10805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A85_10815	COG1994	Peptidase M50
K4A85_10820	COG1942	4-Oxalocrotonate Tautomerase
K4A85_10830	COG3465	dGTPase activity
K4A85_10835	COG1078	dGTPase activity
K4A85_10840	COG4844	belongs to the
K4A85_10900	COG0280	phosphate acetyltransferase
K4A85_10910	COG2814	Major facilitator Superfamily
K4A85_10915	COG1522	sequence-specific DNA binding
K4A85_10920	COG2814	Major facilitator Superfamily
K4A85_10925	COG0077	Prephenate dehydratase
K4A85_10930	COG1917	Cupin 2, conserved barrel domain protein
K4A85_10935	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_10940	COG0151	Belongs to the GarS family
K4A85_10945	COG0436	Aminotransferase
K4A85_10950	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_10955	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K4A85_10960	COG1091	dTDP-4-dehydrorhamnose reductase activity
K4A85_10965	COG1088	dTDP-glucose 4,6-dehydratase activity
K4A85_10970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K4A85_10975	COG3980	spore coat polysaccharide biosynthesis protein
K4A85_10980	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
K4A85_10985	COG2089	acid synthase
K4A85_11000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K4A85_11005	COG0463	Glycosyl transferase, family 2
K4A85_11025	COG2363	Small membrane protein
K4A85_11030	COG2233	PERMEase
K4A85_11040	COG1012	belongs to the aldehyde dehydrogenase family
K4A85_11045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K4A85_11050	COG1216	Glycosyl transferase, family 2
K4A85_11060	COG0351	phosphomethylpyrimidine kinase
K4A85_11075	COG1621	beta-fructofuranosidase activity
K4A85_11080	COG1263	PTS System
K4A85_11080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_11105	COG3711	transcriptional antiterminator
K4A85_11115	COG1404	Belongs to the peptidase S8 family
K4A85_11120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4A85_11125	COG0778	Nitroreductase
K4A85_11130	COG0772	Belongs to the SEDS family
K4A85_11140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K4A85_11145	COG1845	cytochrome c oxidase, subunit III
K4A85_11150	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K4A85_11155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K4A85_11165	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K4A85_11170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K4A85_11175	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K4A85_11190	COG2246	polysaccharide biosynthetic process
K4A85_11210	COG3162	membrane
K4A85_11215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4A85_11225	COG0352	thiamine-phosphate diphosphorylase activity
K4A85_11235	COG0583	DNA-binding transcription factor activity
K4A85_11245	COG1346	cytolysis
K4A85_11250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K4A85_11255	COG0346	lactoylglutathione lyase activity
K4A85_11265	COG0765	amino acid transport
K4A85_11270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_11275	COG0457	Tetratricopeptide repeat
K4A85_11285	COG2357	RelA SpoT domain protein
K4A85_11290	COG1172	Belongs to the binding-protein-dependent transport system permease family
K4A85_11295	COG1129	ABC transporter
K4A85_11305	COG3420	alginic acid biosynthetic process
K4A85_11310	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4A85_11320	COG1486	melibiose metabolic process
K4A85_11325	COG1447	Phosphotransferase system cellobiose-specific component IIA
K4A85_11330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4A85_11335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4A85_11340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_11340	COG3711	transcriptional antiterminator
K4A85_11355	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K4A85_11370	COG1595	DNA-templated transcription, initiation
K4A85_11380	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K4A85_11385	COG4988	ABC transporter
K4A85_11390	COG1294	oxidase, subunit
K4A85_11395	COG1271	oxidase subunit
K4A85_11415	COG4509	Sortase family
K4A85_11440	COG5386	Cell surface protein
K4A85_11445	COG5386	Cell surface protein
K4A85_11450	COG1733	regulation of RNA biosynthetic process
K4A85_11475	COG1447	Phosphotransferase system cellobiose-specific component IIA
K4A85_11480	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4A85_11485	COG2723	6-phospho-beta-galactosidase activity
K4A85_11495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K4A85_11515	COG1757	Na H antiporter
K4A85_11520	COG1027	Aspartate ammonia-lyase
K4A85_11525	COG0252	asparaginase activity
K4A85_11530	COG1396	sequence-specific DNA binding
K4A85_11555	COG4842	Belongs to the WXG100 family
K4A85_11560	COG2195	Cleaves the N-terminal amino acid of tripeptides
K4A85_11575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K4A85_11580	COG2723	6-phospho-beta-galactosidase activity
K4A85_11585	COG1263	PTS System
K4A85_11585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_11585	COG2190	(PTS) system
K4A85_11590	COG3711	transcriptional antiterminator
K4A85_11595	COG3878	Protein conserved in bacteria
K4A85_11605	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K4A85_11610	COG1122	ATPase activity
K4A85_11615	COG4721	ABC-type cobalt transport system, permease component
K4A85_11620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K4A85_11655	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K4A85_11660	COG0778	Nitroreductase
K4A85_11665	COG1846	Transcriptional regulator
K4A85_11670	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K4A85_11675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K4A85_11680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K4A85_11685	COG2390	Transcriptional regulator
K4A85_11695	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K4A85_11695	COG2755	lipolytic protein G-D-S-L family
K4A85_11720	COG0789	Transcriptional regulator
K4A85_11725	COG0673	inositol 2-dehydrogenase activity
K4A85_11730	COG0840	transmembrane signaling receptor activity
K4A85_11735	COG1113	amino acid transport
K4A85_11740	COG4335	DNA alkylation repair
K4A85_11750	COG1070	Carbohydrate kinase
K4A85_11755	COG1737	Transcriptional regulator
K4A85_11775	COG0583	DNA-binding transcription factor activity
K4A85_11780	COG1609	Transcriptional regulator
K4A85_11790	COG1175	transmembrane transport
K4A85_11795	COG3833	ABC-type maltose transport systems, permease component
K4A85_11805	COG1874	Beta-galactosidase
K4A85_11810	COG2851	Citrate transporter
K4A85_11820	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K4A85_11825	COG1131	(ABC) transporter
K4A85_11830	COG2824	Alkylphosphonate utilization operon protein PhnA
K4A85_11835	COG1929	Belongs to the glycerate kinase type-1 family
K4A85_11840	COG2610	gluconate transmembrane transporter activity
K4A85_11845	COG3835	regulator
K4A85_11850	COG1309	transcriptional regulator
K4A85_11855	COG2814	Major facilitator Superfamily
K4A85_11865	COG1136	(ABC) transporter
K4A85_11875	COG0457	Tetratricopeptide repeat
K4A85_11885	COG2723	6-phospho-beta-galactosidase activity
K4A85_11890	COG1263	PTS System
K4A85_11890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_11890	COG2190	(PTS) system
K4A85_11925	COG1113	amino acid transport
K4A85_11930	COG1609	Transcriptional regulator
K4A85_11935	COG2814	Major facilitator Superfamily
K4A85_11940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K4A85_11945	COG2814	Major facilitator Superfamily
K4A85_11960	COG5444	nuclease activity
K4A85_11975	COG2723	6-phospho-beta-galactosidase activity
K4A85_11985	COG2188	Transcriptional regulator
K4A85_12010	COG1131	(ABC) transporter
K4A85_12015	COG1396	sequence-specific DNA binding
K4A85_12025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A85_12030	COG2814	Major facilitator Superfamily
K4A85_12035	COG0640	Transcriptional regulator
K4A85_12040	COG0038	chloride channel
K4A85_12045	COG2323	membrane
K4A85_12050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K4A85_12060	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K4A85_12070	COG4720	Psort location CytoplasmicMembrane, score
K4A85_12090	COG0456	acetyltransferase
K4A85_12095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K4A85_12100	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K4A85_12105	COG4853	Protein conserved in bacteria
K4A85_12110	COG4863	YycH protein
K4A85_12115	COG5002	protein histidine kinase activity
K4A85_12120	COG0745	RESPONSE REGULATOR receiver
K4A85_12145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_12155	COG2311	Membrane
K4A85_12160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K4A85_12190	COG2819	hydrolase of the alpha beta superfamily
K4A85_12195	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_12200	COG1169	isochorismate synthase
K4A85_12205	COG1021	2,3-dihydroxybenzoate-AMP ligase
K4A85_12210	COG1535	isochorismatase
K4A85_12210	COG3433	isochorismatase activity
K4A85_12215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A85_12220	COG3251	PFAM MbtH domain protein
K4A85_12225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_12225	COG2207	Transcriptional regulator
K4A85_12230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K4A85_12235	COG2819	hydrolase of the alpha beta superfamily
K4A85_12240	COG3093	addiction module antidote protein HigA
K4A85_12260	COG4241	membrane
K4A85_12265	COG1227	inorganic diphosphatase activity
K4A85_12275	COG1595	DNA-templated transcription, initiation
K4A85_12285	COG0753	catalase activity
K4A85_12290	COG0655	NAD(P)H dehydrogenase (quinone) activity
K4A85_12295	COG0400	carboxylic ester hydrolase activity
K4A85_12300	COG0346	lactoylglutathione lyase activity
K4A85_12305	COG1174	glycine betaine transport
K4A85_12310	COG0517	IMP dehydrogenase activity
K4A85_12310	COG1125	glycine betaine transport
K4A85_12315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K4A85_12320	COG0629	single-stranded DNA binding
K4A85_12325	COG0360	Binds together with S18 to 16S ribosomal RNA
K4A85_12330	COG0012	GTP binding
K4A85_12335	COG4481	Protein conserved in bacteria
K4A85_12350	COG3949	Membrane
K4A85_12360	COG1475	DNA binding
K4A85_12365	COG1192	Involved in chromosome partitioning
K4A85_12375	COG1475	DNA binding
K4A85_12380	COG0357	Ribosomal RNA small subunit methyltransferase G
K4A85_12385	COG0445	tRNA wobble uridine modification
K4A85_12390	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K4A85_12395	COG1847	R3H domain protein
K4A85_12400	COG0706	membrane insertase activity
K4A85_12405	COG0594	ribonuclease P activity
K4A85_12410	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K4A85_12415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K4A85_12420	COG0592	DNA-directed DNA polymerase activity
K4A85_12425	COG2501	S4 domain
K4A85_12430	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K4A85_12440	COG0187	DNA topoisomerase II activity
K4A85_12445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K4A85_12480	COG0516	GMP reductase activity
K4A85_12480	COG0517	IMP dehydrogenase activity
K4A85_12485	COG1686	Belongs to the peptidase S11 family
K4A85_12490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4A85_12495	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K4A85_12500	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K4A85_12505	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K4A85_12510	COG0840	transmembrane signaling receptor activity
K4A85_12520	COG1428	Deoxynucleoside kinase
K4A85_12525	COG1428	Deoxynucleoside kinase
K4A85_12530	COG3858	chitin binding
K4A85_12530	COG1388	LysM domain
K4A85_12535	COG1335	isochorismatase
K4A85_12540	COG0590	tRNA wobble adenosine to inosine editing
K4A85_12550	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K4A85_12555	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K4A85_12560	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K4A85_12605	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K4A85_12610	COG3853	Toxic anion resistance protein (TelA)
K4A85_12615	COG1982	Orn Lys Arg decarboxylase major
K4A85_12620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K4A85_12625	COG3870	Protein conserved in bacteria
K4A85_12630	COG1728	Protein conserved in bacteria
K4A85_12635	COG0470	DNA polymerase III
K4A85_12640	COG1774	PSP1 C-terminal conserved region
K4A85_12645	COG4467	Involved in initiation control of chromosome replication
K4A85_12650	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K4A85_12655	COG2827	Endonuclease containing a URI domain
K4A85_12660	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K4A85_12665	COG2002	toxin-antitoxin pair type II binding
K4A85_12670	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A85_12670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K4A85_12675	COG0084	hydrolase, TatD family'
K4A85_12680	COG3584	3D domain protein
K4A85_12680	COG3583	domain protein
K4A85_12685	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K4A85_12690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K4A85_12700	COG4466	Protein conserved in bacteria
K4A85_12710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K4A85_12715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K4A85_12720	COG0251	oxidation-reduction process
K4A85_12725	COG2088	sporulation resulting in formation of a cellular spore
K4A85_12735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K4A85_12740	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K4A85_12745	COG0193	aminoacyl-tRNA hydrolase activity
K4A85_12755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K4A85_12760	COG2002	toxin-antitoxin pair type II binding
K4A85_12765	COG2244	polysaccharide biosynthetic process
K4A85_12770	COG3956	TIGRFAM MazG family protein
K4A85_12775	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K4A85_12790	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K4A85_12795	COG1098	S1 RNA binding domain
K4A85_12810	COG2208	phosphoserine phosphatase activity
K4A85_12815	COG2304	oxidoreductase activity
K4A85_12820	COG0515	serine threonine protein kinase
K4A85_12825	COG0037	tRNA processing
K4A85_12830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K4A85_12835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K4A85_12840	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K4A85_12855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K4A85_12860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K4A85_12865	COG0512	Glutamine amidotransferase of anthranilate synthase
K4A85_12870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K4A85_12875	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K4A85_12880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K4A85_12885	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K4A85_12890	COG1396	sequence-specific DNA binding
K4A85_12895	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K4A85_12900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K4A85_12975	COG4463	regulation of RNA biosynthetic process
K4A85_12990	COG0542	response to heat
K4A85_12995	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K4A85_13000	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K4A85_13005	COG4956	integral membrane protein (PIN domain superfamily)
K4A85_13010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K4A85_13015	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K4A85_13020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K4A85_13025	COG1045	serine acetyltransferase
K4A85_13030	COG0215	cysteine-tRNA ligase activity
K4A85_13035	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K4A85_13040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K4A85_13045	COG3688	RNA-binding protein containing a PIN domain
K4A85_13065	COG0081	regulation of translation
K4A85_13070	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K4A85_13075	COG0222	ribosome binding
K4A85_13080	COG2813	Specifically methylates the guanine in position
K4A85_13085	COG0085	RNA polymerase activity
K4A85_13090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K4A85_13095	COG1358	cellular component organization or biogenesis
K4A85_13100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K4A85_13105	COG0049	tRNA binding
K4A85_13120	COG0596	Alpha beta hydrolase
K4A85_13130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K4A85_13135	COG0088	Forms part of the polypeptide exit tunnel
K4A85_13140	COG0089	rRNA binding
K4A85_13145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K4A85_13150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K4A85_13155	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
K4A85_13160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K4A85_13170	COG0255	Belongs to the universal ribosomal protein uL29 family
K4A85_13175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K4A85_13180	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K4A85_13185	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
K4A85_13190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K4A85_13195	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K4A85_13200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K4A85_13205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K4A85_13210	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K4A85_13215	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K4A85_13220	COG1841	ribosomal large subunit assembly
K4A85_13225	COG0200	Binds to the 23S rRNA
K4A85_13230	COG0201	protein transport
K4A85_13235	COG0563	adenylate kinase activity
K4A85_13240	COG0024	Methionine aminopeptidase
K4A85_13245	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K4A85_13250	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K4A85_13255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K4A85_13260	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K4A85_13265	COG0202	RNA polymerase activity
K4A85_13270	COG0203	ribosomal protein L17
K4A85_13275	COG1122	ATPase activity
K4A85_13280	COG1122	ATPase activity
K4A85_13285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K4A85_13290	COG0101	tRNA pseudouridine synthase activity
K4A85_13295	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K4A85_13300	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K4A85_13305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4A85_13335	COG0860	N-Acetylmuramoyl-L-alanine amidase
K4A85_13340	COG0489	protein tyrosine kinase activity
K4A85_13350	COG2194	sulfuric ester hydrolase activity
K4A85_13355	COG0726	polysaccharide deacetylase
K4A85_13385	COG0659	secondary active sulfate transmembrane transporter activity
K4A85_13390	COG0385	Bile acid
K4A85_13395	COG3876	Protein conserved in bacteria
K4A85_13400	COG1472	Belongs to the glycosyl hydrolase 3 family
K4A85_13410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_13410	COG1263	PTS System
K4A85_13415	COG1737	Transcriptional regulator
K4A85_13420	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K4A85_13455	COG1595	DNA-templated transcription, initiation
K4A85_13460	COG5662	AntiSigma factor
K4A85_13465	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K4A85_13470	COG4856	YbbR-like protein
K4A85_13475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K4A85_13480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K4A85_13500	COG1131	(ABC) transporter
K4A85_13530	COG2311	Membrane
K4A85_13555	COG1309	transcriptional regulator
K4A85_13570	COG1113	amino acid transport
K4A85_13575	COG0584	glycerophosphoryl diester phosphodiesterase
K4A85_13580	COG2271	Major facilitator Superfamily
K4A85_13590	COG1331	Highly conserved protein containing a thioredoxin domain
K4A85_13605	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4A85_13605	COG0425	Belongs to the sulfur carrier protein TusA family
K4A85_13610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K4A85_13610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K4A85_13615	COG0425	Belongs to the sulfur carrier protein TusA family
K4A85_13620	COG0730	response to heat
K4A85_13630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4A85_13635	COG2814	Major facilitator Superfamily
K4A85_13640	COG1846	Transcriptional regulator
K4A85_13650	COG1683	Conserved Protein
K4A85_13660	COG0656	L-ascorbic acid biosynthetic process
K4A85_13665	COG0371	Dehydrogenase
K4A85_13670	COG1054	Belongs to the UPF0176 family
K4A85_13675	COG0531	amino acid
K4A85_13685	COG3711	transcriptional antiterminator
K4A85_13690	COG1263	PTS System
K4A85_13690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_13690	COG2190	(PTS) system
K4A85_13695	COG2723	6-phospho-beta-galactosidase activity
K4A85_13705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_13705	COG3711	transcriptional antiterminator
K4A85_13710	COG1940	carbohydrate kinase activity
K4A85_13715	COG0383	alpha-mannosidase activity
K4A85_13735	COG1404	Belongs to the peptidase S8 family
K4A85_13750	COG0833	amino acid
K4A85_13755	COG2040	homocysteine
K4A85_13760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4A85_13765	COG1695	Transcriptional regulator
K4A85_13780	COG2814	Major facilitator Superfamily
K4A85_13785	COG0456	acetyltransferase
K4A85_13800	COG1404	Belongs to the peptidase S8 family
K4A85_13810	COG1309	transcriptional regulator
K4A85_13815	COG1917	Cupin 2, conserved barrel domain protein
K4A85_13820	COG1063	alcohol dehydrogenase
K4A85_13825	COG1846	Transcriptional regulator
K4A85_13830	COG0318	PFAM AMP-dependent synthetase and ligase
K4A85_13835	COG0531	amino acid
K4A85_13850	COG0596	Alpha beta hydrolase
K4A85_13865	COG4191	Histidine kinase
K4A85_13870	COG0784	Response regulator, receiver
K4A85_13875	COG1405	negative regulation of cell septum assembly
K4A85_13875	COG3012	SEC-C Motif Domain Protein
K4A85_13885	COG0667	Aldo Keto reductase
K4A85_13890	COG3290	protein histidine kinase activity
K4A85_13895	COG3279	Response regulator of the LytR AlgR family
K4A85_13900	COG4555	ABC transporter
K4A85_13905	COG1668	transmembrane transport
K4A85_13925	COG3773	Cell wall hydrolase
K4A85_13930	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_13940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4A85_13950	COG2310	stress, protein
K4A85_13955	COG2310	stress, protein
K4A85_13960	COG0861	Integral membrane protein TerC family
K4A85_13990	COG3853	Toxic anion resistance protein (TelA)
K4A85_13995	COG0517	IMP dehydrogenase activity
K4A85_13995	COG4175	Glycine betaine
K4A85_14000	COG4176	ABC-type proline glycine betaine transport system permease component
K4A85_14005	COG2113	Glycine betaine
K4A85_14020	COG1473	amidohydrolase
K4A85_14025	COG1288	antiporter activity
K4A85_14030	COG0039	L-malate dehydrogenase activity
K4A85_14035	COG1620	l-lactate permease
K4A85_14040	COG1609	Transcriptional regulator
K4A85_14045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K4A85_14050	COG0561	phosphatase activity
K4A85_14055	COG0673	inositol 2-dehydrogenase activity
K4A85_14060	COG0738	Major facilitator superfamily
K4A85_14065	COG1280	lysine exporter protein (LysE YggA)
K4A85_14075	COG3403	YqcI/YcgG family
K4A85_14080	COG1113	amino acid transport
K4A85_14085	COG3665	Urea carboxylase-associated protein
K4A85_14090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K4A85_14095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K4A85_14105	COG0477	Major facilitator Superfamily
K4A85_14110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K4A85_14115	COG2226	methyltransferase
K4A85_14120	COG0583	DNA-binding transcription factor activity
K4A85_14125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4A85_14130	COG3458	cephalosporin-C deacetylase activity
K4A85_14140	COG3541	Predicted nucleotidyltransferase
K4A85_14145	COG0506	proline dehydrogenase activity
K4A85_14150	COG1012	belongs to the aldehyde dehydrogenase family
K4A85_14155	COG2508	Transcriptional regulator
K4A85_14160	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K4A85_14165	COG0765	amino acid transport
K4A85_14170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_14180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K4A85_14185	COG1522	sequence-specific DNA binding
K4A85_14190	COG2746	aminoglycoside 3-N-acetyltransferase activity
K4A85_14200	COG0840	transmembrane signaling receptor activity
K4A85_14200	COG3290	protein histidine kinase activity
K4A85_14205	COG3209	COG3209 Rhs family protein
K4A85_14230	COG3842	ATPase activity
K4A85_14235	COG1176	ABC-type spermidine putrescine transport system, permease component I
K4A85_14255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K4A85_14270	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K4A85_14275	COG0697	spore germination
K4A85_14280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4A85_14290	COG2364	Membrane
K4A85_14295	COG1126	abc transporter atp-binding protein
K4A85_14300	COG0765	amino acid transport
K4A85_14305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_14310	COG0833	amino acid
K4A85_14315	COG3104	oligopeptide transport
K4A85_14320	COG5434	Belongs to the glycosyl hydrolase 28 family
K4A85_14325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K4A85_14330	COG0456	acetyltransferase
K4A85_14335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K4A85_14340	COG0765	amino acid transport
K4A85_14345	COG1126	abc transporter atp-binding protein
K4A85_14350	COG1473	amidohydrolase
K4A85_14355	COG2079	MmgE PrpD family protein
K4A85_14360	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_14365	COG0527	aspartate kinase activity
K4A85_14370	COG2814	Major facilitator Superfamily
K4A85_14375	COG1309	transcriptional regulator
K4A85_14385	COG0640	Transcriptional regulator
K4A85_14390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4A85_14395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K4A85_14400	COG0531	amino acid
K4A85_14405	COG1012	belongs to the aldehyde dehydrogenase family
K4A85_14410	COG2249	NAD(P)H dehydrogenase (quinone) activity
K4A85_14415	COG4549	nuclear export factor GLE1
K4A85_14420	COG1276	copper resistance
K4A85_14420	COG2372	response to copper ion
K4A85_14425	COG2213	PTS system mannitol-specific
K4A85_14430	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K4A85_14435	COG0246	Mannitol dehydrogenase
K4A85_14465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K4A85_14470	COG1914	H( )-stimulated, divalent metal cation uptake system
K4A85_14475	COG4336	lyase activity
K4A85_14480	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K4A85_14485	COG1984	allophanate hydrolase subunit 2
K4A85_14490	COG1414	Transcriptional regulator
K4A85_14495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K4A85_14500	COG2755	lipolytic protein G-D-S-L family
K4A85_14510	COG3711	transcriptional antiterminator
K4A85_14515	COG2226	methyltransferase
K4A85_14520	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_14525	COG3871	stress protein (general stress protein 26)
K4A85_14540	COG2814	Major facilitator Superfamily
K4A85_14545	COG1802	Transcriptional regulator
K4A85_14550	COG1917	Cupin 2, conserved barrel domain protein
K4A85_14550	COG2207	Transcriptional regulator
K4A85_14555	COG0697	spore germination
K4A85_14560	COG0473	3-isopropylmalate dehydrogenase activity
K4A85_14565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K4A85_14565	COG0551	DNA topoisomerase type I activity
K4A85_14570	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K4A85_14575	COG3706	GGDEF domain
K4A85_14580	COG5298	Protein conserved in bacteria
K4A85_14585	COG1215	transferase activity, transferring glycosyl groups
K4A85_14595	COG0531	amino acid
K4A85_14600	COG0028	Belongs to the TPP enzyme family
K4A85_14635	COG2261	transglycosylase associated protein
K4A85_14655	COG4565	transcriptional regulatory protein
K4A85_14665	COG0628	permease
K4A85_14670	COG1301	dicarboxylic acid transport
K4A85_14675	COG1131	(ABC) transporter
K4A85_14680	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K4A85_14695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K4A85_14700	COG1181	Belongs to the D-alanine--D-alanine ligase family
K4A85_14705	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K4A85_14720	COG0513	Belongs to the DEAD box helicase family
K4A85_14725	COG3402	PFAM membrane-flanked domain
K4A85_14730	COG3428	Bacterial PH domain
K4A85_14735	COG0705	Rhomboid family
K4A85_14740	COG0736	holo-[acyl-carrier-protein] synthase activity
K4A85_14745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K4A85_14750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K4A85_14755	COG0864	Transcriptional regulator
K4A85_14760	COG2337	Toxic component of a toxin-antitoxin (TA) module
K4A85_14765	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_14770	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_14775	COG2172	sigma factor antagonist activity
K4A85_14780	COG2208	phosphoserine phosphatase activity
K4A85_14785	COG1366	Belongs to the anti-sigma-factor antagonist family
K4A85_14790	COG2172	sigma factor antagonist activity
K4A85_14795	COG1191	sigma factor activity
K4A85_14800	COG2208	phosphoserine phosphatase activity
K4A85_14805	COG2183	response to ionizing radiation
K4A85_14815	COG3091	SprT-like family
K4A85_14820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K4A85_14830	COG0508	dehydrogenase complex catalyzes the overall conversion of
K4A85_14835	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K4A85_14840	COG3284	Transcriptional regulator
K4A85_14880	COG0604	alcohol dehydrogenase
K4A85_14890	COG0456	acetyltransferase
K4A85_14890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K4A85_14895	COG1278	Cold shock
K4A85_14900	COG1329	Transcriptional regulator
K4A85_14905	COG1064	alcohol dehydrogenase
K4A85_14910	COG0789	Transcriptional regulator
K4A85_14925	COG0477	Major facilitator Superfamily
K4A85_14930	COG0657	acetylesterase activity
K4A85_14960	COG0252	asparaginase activity
K4A85_14980	COG2814	Major facilitator Superfamily
K4A85_15015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K4A85_15020	COG1846	Transcriptional regulator
K4A85_15025	COG0778	Nitroreductase
K4A85_15040	COG1396	sequence-specific DNA binding
K4A85_15050	COG0456	acetyltransferase
K4A85_15055	COG0583	DNA-binding transcription factor activity
K4A85_15060	COG0667	Aldo Keto reductase
K4A85_15070	COG4122	O-methyltransferase activity
K4A85_15080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K4A85_15085	COG0697	spore germination
K4A85_15095	COG1301	dicarboxylic acid transport
K4A85_15135	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K4A85_15140	COG0802	atpase or kinase
K4A85_15145	COG1214	PFAM Peptidase M22, glycoprotease
K4A85_15150	COG0456	acetyltransferase
K4A85_15155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K4A85_15160	COG0488	(ABC) transporter
K4A85_15165	COG0315	cyclic pyranopterin monophosphate synthase activity
K4A85_15170	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K4A85_15175	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K4A85_15180	COG0805	protein transport
K4A85_15185	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K4A85_15195	COG1266	CAAX protease self-immunity
K4A85_15200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K4A85_15205	COG0459	protein refolding
K4A85_15220	COG0456	acetyltransferase
K4A85_15225	COG2808	Putative FMN-binding domain
K4A85_15245	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K4A85_15250	COG0823	Involved in the tonB-independent uptake of proteins
K4A85_15265	COG2132	Multicopper oxidase
K4A85_15270	COG1113	amino acid transport
K4A85_15275	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K4A85_15280	COG0714	Associated with various cellular activities
K4A85_15285	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K4A85_15290	COG1305	Transglutaminase-like
K4A85_15295	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K4A85_15295	COG0519	Catalyzes the synthesis of GMP from XMP
K4A85_15305	COG1917	Cupin 2, conserved barrel domain protein
K4A85_15305	COG2207	Transcriptional regulator
K4A85_15310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K4A85_15315	COG2207	Transcriptional regulator
K4A85_15345	COG1595	DNA-templated transcription, initiation
K4A85_15355	COG2814	Major facilitator Superfamily
K4A85_15360	COG0583	DNA-binding transcription factor activity
K4A85_15365	COG2252	PERMEase
K4A85_15370	COG3064	Membrane
K4A85_15375	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K4A85_15385	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K4A85_15390	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K4A85_15395	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K4A85_15400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K4A85_15405	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K4A85_15410	COG0047	phosphoribosylformylglycinamidine synthase activity
K4A85_15415	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K4A85_15420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K4A85_15425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K4A85_15430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K4A85_15435	COG0138	bifunctional purine biosynthesis protein purh
K4A85_15440	COG0151	Belongs to the GarS family
K4A85_15475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K4A85_15485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K4A85_15490	COG4496	protein, YerC YecD
K4A85_15495	COG0069	glutamate synthase activity
K4A85_15510	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
K4A85_15515	COG0210	DNA helicase
K4A85_15520	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K4A85_15525	COG4851	CamS sex pheromone cAM373 precursor
K4A85_15540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K4A85_15555	COG1250	3-hydroxyacyl-CoA dehydrogenase
K4A85_15570	COG1960	acyl-CoA dehydrogenase activity
K4A85_15600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K4A85_15605	COG1785	Belongs to the alkaline phosphatase family
K4A85_15610	COG1285	pathogenesis
K4A85_15615	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K4A85_15620	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K4A85_15625	COG0154	amidase activity
K4A85_15630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K4A85_15640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K4A85_15645	COG1957	nucleoside hydrolase
K4A85_15650	COG1597	lipid kinase activity
K4A85_15655	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K4A85_15675	COG1737	Transcriptional regulator
K4A85_15680	COG1263	PTS System
K4A85_15680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_15700	COG0492	ferredoxin-NADP+ reductase activity
K4A85_15715	COG1486	melibiose metabolic process
K4A85_15725	COG2211	Major facilitator Superfamily
K4A85_15755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K4A85_15760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K4A85_15765	COG1442	glycosyl transferase family 8
K4A85_15770	COG1216	Glycosyl transferase, family 2
K4A85_15775	COG1442	glycosyl transferase family 8
K4A85_15780	COG2223	nitrite transmembrane transporter activity
K4A85_15790	COG0471	metal ion transport
K4A85_15795	COG0531	amino acid
K4A85_15800	COG0457	Tetratricopeptide repeat
K4A85_15800	COG0463	Glycosyl transferase, family 2
K4A85_15805	COG0488	(ABC) transporter
K4A85_15810	COG1469	GTP cyclohydrolase I activity
K4A85_15815	COG0789	Transcriptional regulator
K4A85_15820	COG2814	Major facilitator Superfamily
K4A85_15825	COG0488	(ABC) transporter
K4A85_15830	COG0513	Belongs to the DEAD box helicase family
K4A85_15835	COG2130	NADP-dependent
K4A85_15855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A85_15855	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K4A85_15860	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K4A85_15870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4A85_15870	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K4A85_15890	COG3290	protein histidine kinase activity
K4A85_15895	COG4565	transcriptional regulatory protein
K4A85_15900	COG3181	Tripartite tricarboxylate transporter family receptor
K4A85_15905	COG2851	Citrate transporter
K4A85_15915	COG3479	Phenolic acid decarboxylase
K4A85_15920	COG1695	Transcriptional regulator
K4A85_15925	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K4A85_15930	COG1254	Belongs to the acylphosphatase family
K4A85_15935	COG2258	MOSC domain
K4A85_15945	COG0024	Methionine aminopeptidase
K4A85_15950	COG1263	PTS System
K4A85_15950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_15955	COG3739	integral membrane protein
K4A85_15970	COG1368	sulfuric ester hydrolase activity
K4A85_15975	COG0076	glutamate decarboxylase activity
K4A85_15980	COG0840	transmembrane signaling receptor activity
K4A85_15990	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K4A85_15990	COG1263	PTS System
K4A85_15995	COG0366	Alpha amylase catalytic
K4A85_16000	COG2188	Transcriptional regulator
K4A85_16010	COG0737	Belongs to the 5'-nucleotidase family
K4A85_16015	COG0693	protein deglycase activity
K4A85_16020	COG4840	Belongs to the UPF0435 family
K4A85_16025	COG1115	amino acid carrier protein
K4A85_16030	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K4A85_16035	COG4980	gas vesicle protein
K4A85_16040	COG1295	ribonuclease BN
K4A85_16045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K4A85_16050	COG0477	Major facilitator Superfamily
K4A85_16060	COG0387	Pfam Sodium calcium exchanger
K4A85_16075	COG4152	abc transporter atp-binding protein
K4A85_16095	COG0217	transcriptional regulatory protein
K4A85_16105	COG0668	transmembrane transport
K4A85_16110	COG0535	radical SAM domain protein
K4A85_16120	COG0726	polysaccharide deacetylase
K4A85_16130	COG0598	Magnesium transport protein CorA
K4A85_16140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K4A85_16145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K4A85_16155	COG0789	Transcriptional regulator
K4A85_16160	COG2814	Major facilitator Superfamily
K4A85_16175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K4A85_16215	COG2076	Multidrug Resistance protein
K4A85_16220	COG2076	Multidrug Resistance protein
K4A85_16225	COG1309	transcriptional regulator
K4A85_16235	COG4637	Psort location Cytoplasmic, score
K4A85_16240	COG2755	lipolytic protein G-D-S-L family
K4A85_16245	COG0492	ferredoxin-NADP+ reductase activity
K4A85_16250	COG1742	UPF0060 membrane protein
K4A85_16265	COG2318	DinB family
K4A85_16275	COG1846	Transcriptional regulator
K4A85_16280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K4A85_16280	COG0392	lysyltransferase activity
K4A85_16300	COG0778	Nitroreductase
K4A85_16315	COG1090	epimerase
K4A85_16320	COG2137	regulation of response to DNA damage stimulus
K4A85_16345	COG0463	Glycosyl transferase, family 2
K4A85_16350	COG4485	Bacterial membrane protein, YfhO
K4A85_16365	COG2140	Oxalate decarboxylase
K4A85_16375	COG1191	sigma factor activity
K4A85_16385	COG1988	membrane-bound metal-dependent
K4A85_16390	COG1194	a g-specific adenine glycosylase
K4A85_16400	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_16415	COG3557	Belongs to the UPF0374 family
K4A85_16420	COG1132	(ABC) transporter
K4A85_16425	COG0444	Belongs to the ABC transporter superfamily
K4A85_16430	COG4608	Belongs to the ABC transporter superfamily
K4A85_16435	COG0747	negative chemotaxis
K4A85_16440	COG0601	transmembrane transport
K4A85_16445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4A85_16450	COG4129	membrane
K4A85_16455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K4A85_16460	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K4A85_16465	COG0735	belongs to the Fur family
K4A85_16605	COG1368	sulfuric ester hydrolase activity
K4A85_16610	COG0681	Belongs to the peptidase S26 family
K4A85_16615	COG2873	o-acetylhomoserine
K4A85_16625	COG1131	(ABC) transporter
K4A85_16655	COG3382	B3 4 domain protein
K4A85_16660	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K4A85_16670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K4A85_16680	COG2766	serine protein kinase
K4A85_16685	COG2718	Belongs to the UPF0229 family
K4A85_16690	COG1566	PFAM secretion protein HlyD family protein
K4A85_16695	COG2814	Major facilitator Superfamily
K4A85_16700	COG0655	NAD(P)H dehydrogenase (quinone) activity
K4A85_16710	COG1278	Cold shock
K4A85_16715	COG3706	GGDEF domain
K4A85_16750	COG4085	toxin activity
K4A85_16750	COG1525	nuclease
K4A85_16750	COG0737	Belongs to the 5'-nucleotidase family
K4A85_16755	COG3764	Sortase (surface protein transpeptidase)
K4A85_16760	COG0564	pseudouridine synthase activity
K4A85_16770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K4A85_16775	COG3153	acetyltransferase
K4A85_16775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K4A85_16790	COG3835	regulator
K4A85_16795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K4A85_16800	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K4A85_16805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K4A85_16810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K4A85_16830	COG2197	response regulator
K4A85_16850	COG0753	catalase activity
K4A85_16855	COG1959	2 iron, 2 sulfur cluster binding
K4A85_16860	COG1017	nitric oxide dioxygenase activity
K4A85_16860	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K4A85_16865	COG2719	SpoVR family
K4A85_16870	COG1785	Belongs to the alkaline phosphatase family
K4A85_16875	COG0791	NLP P60 protein
K4A85_16875	COG1388	LysM domain
K4A85_16890	COG1595	DNA-templated transcription, initiation
K4A85_16895	COG0204	Acyl-transferase
K4A85_16900	COG1253	flavin adenine dinucleotide binding
K4A85_16905	COG0789	Transcriptional regulator
K4A85_16910	COG1253	flavin adenine dinucleotide binding
K4A85_16925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K4A85_16930	COG0584	glycerophosphoryl diester phosphodiesterase
K4A85_16940	COG0668	transmembrane transport
K4A85_16945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K4A85_16950	COG0726	polysaccharide deacetylase
K4A85_16960	COG0589	response to stress
K4A85_16965	COG1132	(ABC) transporter
K4A85_16975	COG0702	epimerase
K4A85_16985	COG3842	ATPase activity
K4A85_16990	COG2508	Transcriptional regulator
K4A85_17000	COG0189	ligase activity
K4A85_17005	COG0189	ligase activity
K4A85_17010	COG4399	Belongs to the UPF0754 family
K4A85_17015	COG3679	Belongs to the UPF0342 family
K4A85_17020	COG0561	phosphatase activity
K4A85_17025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K4A85_17035	COG0475	glutathione-regulated potassium exporter activity
K4A85_17040	COG0490	domain, Protein
K4A85_17045	COG1024	Enoyl-CoA hydratase
K4A85_17055	COG0420	3'-5' exonuclease activity
K4A85_17060	COG4717	serine-type aminopeptidase activity
K4A85_17065	COG3481	metal-dependent phosphohydrolase, HD sub domain
K4A85_17075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K4A85_17100	COG1846	Transcriptional regulator
K4A85_17105	COG4980	gas vesicle protein
K4A85_17125	COG0537	adenosine 5'-monophosphoramidase activity
K4A85_17130	COG1131	(ABC) transporter
K4A85_17135	COG4473	ABC transporter
K4A85_17155	COG2329	Antibiotic biosynthesis monooxygenase
K4A85_17160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K4A85_17165	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K4A85_17170	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K4A85_17175	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K4A85_17180	COG1309	transcriptional regulator
K4A85_17185	COG1511	domain protein
K4A85_17190	COG1363	Peptidase, m42
K4A85_17195	COG1301	dicarboxylic acid transport
K4A85_17220	COG1404	Belongs to the peptidase S8 family
K4A85_17225	COG0406	alpha-ribazole phosphatase activity
K4A85_17230	COG0840	transmembrane signaling receptor activity
K4A85_17235	COG0723	plastoquinol--plastocyanin reductase activity
K4A85_17235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K4A85_17240	COG1028	Short-chain dehydrogenase reductase Sdr
K4A85_17250	COG4903	ComK protein
K4A85_17265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K4A85_17270	COG2814	Major facilitator Superfamily
K4A85_17275	COG2732	(Barnase) inhibitor
K4A85_17280	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K4A85_17285	COG4605	iron ion homeostasis
K4A85_17290	COG4604	ABC transporter, ATP-binding protein
K4A85_17295	COG4607	ABC-type enterochelin transport system periplasmic component
K4A85_17300	COG1316	TRANSCRIPTIONal
K4A85_17310	COG0398	Pfam SNARE associated Golgi protein
K4A85_17315	COG0681	Belongs to the peptidase S26 family
K4A85_17320	COG3180	Ammonia monooxygenase
K4A85_17335	COG2259	Doxx family
K4A85_17340	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K4A85_17345	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K4A85_17355	COG0420	3'-5' exonuclease activity
K4A85_17360	COG0419	ATPase involved in DNA repair
K4A85_17365	COG1403	HNH endonuclease
K4A85_17405	COG5337	Spore coat protein CotH
K4A85_17415	COG0179	Fumarylacetoacetate (FAA) hydrolase
K4A85_17430	COG0367	asparagine synthase
K4A85_17445	COG1562	ergosterol biosynthetic process
K4A85_17450	COG0534	Mate efflux family protein
K4A85_17455	COG1917	Cupin 2, conserved barrel domain protein
K4A85_17455	COG2207	Transcriptional regulator
K4A85_17480	COG0076	glutamate decarboxylase activity
K4A85_17515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K4A85_17515	COG0646	methionine synthase
K4A85_17520	COG1666	GTP binding
K4A85_17525	COG2996	Protein conserved in bacteria
K4A85_17530	COG1744	ABC transporter substrate-binding protein PnrA-like
K4A85_17535	COG0840	transmembrane signaling receptor activity
K4A85_17540	COG1307	EDD domain protein, DegV family
K4A85_17545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K4A85_17565	COG0561	phosphatase activity
K4A85_17570	COG1073	alpha beta
K4A85_17580	COG0277	FAD linked oxidase domain protein
K4A85_17585	COG2271	Major facilitator Superfamily
K4A85_17590	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K4A85_17595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K4A85_17600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K4A85_17605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K4A85_17610	COG0505	Belongs to the CarA family
K4A85_17615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K4A85_17620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K4A85_17630	COG2814	Major facilitator Superfamily
K4A85_17640	COG2267	carboxylic ester hydrolase activity
K4A85_17650	COG1744	ABC transporter substrate-binding protein PnrA-like
K4A85_17665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K4A85_17670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K4A85_17675	COG5504	Zn-dependent protease
K4A85_17680	COG0444	Belongs to the ABC transporter superfamily
K4A85_17685	COG4608	Belongs to the ABC transporter superfamily
K4A85_17695	COG0601	transmembrane transport
K4A85_17700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K4A85_17710	COG0180	Tryptophanyl-tRNA synthetase
K4A85_17715	COG4166	transmembrane transport
K4A85_17720	COG0601	transmembrane transport
K4A85_17735	COG4608	Belongs to the ABC transporter superfamily
K4A85_17740	COG0456	acetyltransferase
K4A85_17745	COG1393	Belongs to the ArsC family
K4A85_17750	COG0861	Integral membrane protein TerC family
K4A85_17755	COG4862	establishment of competence for transformation
K4A85_17760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K4A85_17770	COG1164	Oligoendopeptidase f
K4A85_17775	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K4A85_17780	COG2346	COG2346, Truncated hemoglobins
K4A85_17785	COG0741	lytic transglycosylase activity
K4A85_17790	COG4116	CYTH
K4A85_17800	COG2357	RelA SpoT domain protein
K4A85_17805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K4A85_17810	COG0564	pseudouridine synthase activity
K4A85_17815	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K4A85_17820	COG0475	glutathione-regulated potassium exporter activity
K4A85_17820	COG0569	domain protein
K4A85_17825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K4A85_17830	COG0352	thiamine-phosphate diphosphorylase activity
K4A85_17840	COG2104	thiamine diphosphate biosynthetic process
K4A85_17845	COG2022	thiamine diphosphate biosynthetic process
K4A85_17850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K4A85_17860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K4A85_17915	COG0210	DNA helicase
K4A85_17925	COG2153	protein acetylation
K4A85_17930	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K4A85_17935	COG2382	esterase
K4A85_17940	COG0626	cystathionine gamma-synthase activity
K4A85_17945	COG0626	cystathionine gamma-synthase activity
K4A85_17955	COG0604	alcohol dehydrogenase
K4A85_17970	COG0825	malonyl-CoA metabolic process
K4A85_18020	COG0457	Tetratricopeptide repeat
K4A85_18045	COG3173	Aminoglycoside phosphotransferase
K4A85_18060	COG0583	DNA-binding transcription factor activity
K4A85_18065	COG2807	transmembrane transport
K4A85_18075	COG0457	Tetratricopeptide repeat
K4A85_18090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K4A85_18100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4A85_18110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K4A85_18130	COG4195	phage-related replication protein
K4A85_18135	COG2856	Zn peptidase
K4A85_18140	COG3409	Peptidoglycan-binding domain 1 protein
K4A85_18140	COG5632	N-Acetylmuramoyl-L-alanine amidase
K4A85_18155	COG0306	phosphate transporter
K4A85_18160	COG1392	Phosphate transport regulator
K4A85_18180	COG3775	system Galactitol-specific IIC component