locus-tag	class	description
ID12_00010	COG3859	Proton-coupled thiamine transporter YuaJ
ID12_00015	COG1247	-acetyltransferase
ID12_00020	COG3339	Conserved Protein
ID12_00025	COG0772	Belongs to the SEDS family
ID12_00030	COG0772	Belongs to the SEDS family
ID12_00035	COG2268	Band 7 protein
ID12_00040	COG1585	Membrane protein implicated in regulation of membrane protease activity
ID12_00045	COG2318	DinB family
ID12_00050	COG1454	alcohol dehydrogenase
ID12_00060	COG1510	regulation of RNA biosynthetic process
ID12_00075	COG5632	N-Acetylmuramoyl-L-alanine amidase
ID12_00075	COG3409	Peptidoglycan-binding domain 1 protein
ID12_00130	COG3778	Protein conserved in bacteria
ID12_00135	COG3299	homolog of phage Mu protein gp47
ID12_00140	COG3628	GPW Gp25 family protein
ID12_00150	COG4193	domain, Protein
ID12_00155	COG1652	LysM domain
ID12_00160	COG5280	Phage tail tape measure protein TP901
ID12_00160	COG3953	SLT domain
ID12_00160	COG5280	Phage tail tape measure protein TP901
ID12_00160	COG3953	SLT domain
ID12_00215	COG4653	Phage capsid family
ID12_00220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ID12_00225	COG5518	Phage portal protein
ID12_00230	COG1783	phage Terminase large subunit
ID12_00235	COG5484	DNA packaging
ID12_00240	COG1595	DNA-templated transcription, initiation
ID12_00250	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
ID12_00275	COG1396	sequence-specific DNA binding
ID12_00290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ID12_00305	COG0628	permease
ID12_00315	COG0673	inositol 2-dehydrogenase activity
ID12_00320	COG0693	protein deglycase activity
ID12_00325	COG0840	transmembrane signaling receptor activity
ID12_00330	COG0840	transmembrane signaling receptor activity
ID12_00335	COG0840	transmembrane signaling receptor activity
ID12_00340	COG0840	transmembrane signaling receptor activity
ID12_00355	COG2070	2-Nitropropane dioxygenase
ID12_00360	COG0432	Pfam Uncharacterised protein family UPF0047
ID12_00365	COG1253	flavin adenine dinucleotide binding
ID12_00370	COG2738	Putative neutral zinc metallopeptidase
ID12_00380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ID12_00395	COG0166	Belongs to the GPI family
ID12_00400	COG1979	alcohol dehydrogenase
ID12_00405	COG1979	alcohol dehydrogenase
ID12_00410	COG2155	Conserved Protein
ID12_00415	COG1098	S1 RNA binding domain
ID12_00420	COG0436	Aminotransferase
ID12_00425	COG1522	sequence-specific DNA binding
ID12_00430	COG2267	carboxylic ester hydrolase activity
ID12_00440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ID12_00445	COG2205	protein histidine kinase activity
ID12_00460	COG5018	Exonuclease
ID12_00465	COG2814	Major facilitator Superfamily
ID12_00470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_00475	COG3011	Protein conserved in bacteria
ID12_00485	COG3290	protein histidine kinase activity
ID12_00490	COG4565	transcriptional regulatory protein
ID12_00515	COG3493	citrate carrier protein
ID12_00530	COG2111	Na H antiporter
ID12_00530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ID12_00535	COG2111	Na H antiporter
ID12_00540	COG1006	Multisubunit Na H antiporter MnhC subunit
ID12_00545	COG0651	ATP synthesis coupled electron transport
ID12_00550	COG1863	multisubunit Na H antiporter MnhE subunit
ID12_00555	COG2212	antiporter activity
ID12_00560	COG1320	monovalent cation:proton antiporter activity
ID12_00565	COG2050	protein possibly involved in aromatic compounds catabolism
ID12_00570	COG2197	response regulator
ID12_00575	COG4585	Histidine kinase
ID12_00585	COG0142	geranyltranstransferase activity
ID12_00600	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ID12_00605	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ID12_00610	COG1335	isochorismatase
ID12_00615	COG5506	Protein of unknown function (DUF1694)
ID12_00635	COG0628	permease
ID12_00650	COG1418	mRNA catabolic process
ID12_00655	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_00665	COG1511	domain protein
ID12_00670	COG0433	COG0433 Predicted ATPase
ID12_00670	COG1674	ftsk spoiiie
ID12_00675	COG4499	WXG100 protein secretion system (Wss), protein YukC
ID12_00680	COG5417	Belongs to the EsaB family
ID12_00685	COG4842	Belongs to the WXG100 family
ID12_00690	COG2508	Transcriptional regulator
ID12_00690	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ID12_00695	COG0686	Belongs to the AlaDH PNT family
ID12_00700	COG1268	BioY protein
ID12_00705	COG2056	Na+-H+ antiporter family
ID12_00710	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ID12_00715	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ID12_00720	COG3584	3D domain protein
ID12_00735	COG1252	NADH dehydrogenase
ID12_00740	COG0492	ferredoxin-NADP+ reductase activity
ID12_00755	COG0316	Belongs to the HesB IscA family
ID12_00760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ID12_00765	COG4844	belongs to the
ID12_00770	COG1252	NADH dehydrogenase
ID12_00780	COG4837	Protein of unknown function (DUF1462)
ID12_00785	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ID12_00790	COG1506	peptidase
ID12_00790	COG0823	Involved in the tonB-independent uptake of proteins
ID12_00790	COG4946	Tricorn protease homolog
ID12_00795	COG0083	homoserine kinase activity
ID12_00800	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ID12_00805	COG0460	homoserine dehydrogenase
ID12_00810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID12_00815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ID12_00820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ID12_00825	COG0647	UMP catabolic process
ID12_00830	COG2445	Protein of unknown function DUF86
ID12_00835	COG4470	Protein conserved in bacteria
ID12_00845	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ID12_00850	COG0739	heme binding
ID12_00870	COG3377	Domain of unknown function (DUF1805)
ID12_00875	COG0737	Belongs to the 5'-nucleotidase family
ID12_00880	COG1801	Protein of unknown function DUF72
ID12_00885	COG2508	Transcriptional regulator
ID12_00890	COG2140	Oxalate decarboxylase
ID12_00895	COG2814	Major facilitator Superfamily
ID12_00900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ID12_00905	COG2356	endonuclease I
ID12_00920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_00925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_00930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_00950	COG5002	protein histidine kinase activity
ID12_00950	COG0642	Histidine kinase
ID12_00955	COG0745	RESPONSE REGULATOR receiver
ID12_00960	COG2311	Membrane
ID12_00970	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID12_00990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ID12_01000	COG0719	Fe-S assembly protein
ID12_01005	COG0822	iron-sulfur transferase activity
ID12_01010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ID12_01015	COG0719	Fe-S assembly protein
ID12_01020	COG0396	ATPase activity
ID12_01030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ID12_01035	COG1464	Belongs to the NlpA lipoprotein family
ID12_01040	COG2011	ABC-type metal ion transport system permease component
ID12_01045	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ID12_01055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_01060	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ID12_01070	COG0509	glycine decarboxylation via glycine cleavage system
ID12_01075	COG1393	Belongs to the ArsC family
ID12_01080	COG1960	acyl-CoA dehydrogenase activity
ID12_01085	COG0183	Belongs to the thiolase family
ID12_01090	COG1024	Enoyl-CoA hydratase
ID12_01090	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID12_01105	COG5577	PFAM Coat F domain
ID12_01115	COG1120	ATPase activity
ID12_01125	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_01130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_01135	COG0745	RESPONSE REGULATOR receiver
ID12_01140	COG2205	protein histidine kinase activity
ID12_01140	COG2770	Histidine kinase
ID12_01150	COG1309	transcriptional regulator
ID12_01155	COG0114	fumarate hydratase activity
ID12_01165	COG0697	spore germination
ID12_01170	COG0814	amino acid
ID12_01185	COG2197	response regulator
ID12_01190	COG4585	Histidine kinase
ID12_01195	COG4758	membrane
ID12_01205	COG1842	Phage shock protein A
ID12_01210	COG4758	membrane
ID12_01215	COG2096	Adenosyltransferase
ID12_01220	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_01225	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ID12_01235	COG3604	Transcriptional regulator
ID12_01250	COG1454	alcohol dehydrogenase
ID12_01255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ID12_01260	COG1120	ATPase activity
ID12_01265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_01270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_01280	COG2721	sulfolactate sulfo-lyase activity
ID12_01285	COG0246	Mannitol dehydrogenase
ID12_01290	COG1609	Transcriptional regulator
ID12_01295	COG1904	glucuronate isomerase
ID12_01300	COG2205	protein histidine kinase activity
ID12_01305	COG0745	RESPONSE REGULATOR receiver
ID12_01310	COG1120	ATPase activity
ID12_01315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_01320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_01325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_01330	COG0531	amino acid
ID12_01345	COG1988	membrane-bound metal-dependent
ID12_01350	COG1368	sulfuric ester hydrolase activity
ID12_01355	COG0725	ABC transporter, periplasmic molybdate-binding protein
ID12_01360	COG4149	molybdate abc transporter
ID12_01365	COG0656	L-ascorbic acid biosynthetic process
ID12_01370	COG1940	carbohydrate kinase activity
ID12_01375	COG0025	NhaP-type Na H and K H
ID12_01380	COG2860	membrane
ID12_01385	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ID12_01390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ID12_01395	COG2217	Heavy metal translocating P-type atpase
ID12_01400	COG1121	(ABC) transporter
ID12_01405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID12_01410	COG0803	Belongs to the bacterial solute-binding protein 9 family
ID12_01420	COG3226	Transcriptional regulator
ID12_01425	COG0784	Response regulator, receiver
ID12_01430	COG4191	Histidine kinase
ID12_01435	COG1027	Aspartate ammonia-lyase
ID12_01450	COG2217	Heavy metal translocating P-type atpase
ID12_01455	COG2608	mercury ion transmembrane transporter activity
ID12_01460	COG1937	Protein conserved in bacteria
ID12_01470	COG0745	RESPONSE REGULATOR receiver
ID12_01470	COG3706	GGDEF domain
ID12_01495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ID12_01500	COG0557	exoribonuclease II activity
ID12_01505	COG1647	Serine aminopeptidase, S33
ID12_01510	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ID12_01515	COG2002	toxin-antitoxin pair type II binding
ID12_01520	COG1476	TRANSCRIPTIONal
ID12_01525	COG1396	sequence-specific DNA binding
ID12_01530	COG1396	sequence-specific DNA binding
ID12_01535	COG1733	regulation of RNA biosynthetic process
ID12_01540	COG1174	glycine betaine transport
ID12_01545	COG1732	Glycine betaine
ID12_01550	COG1174	glycine betaine transport
ID12_01555	COG0517	IMP dehydrogenase activity
ID12_01555	COG1125	glycine betaine transport
ID12_01560	COG1510	regulation of RNA biosynthetic process
ID12_01565	COG2095	MarC family integral membrane protein
ID12_01575	COG0456	acetyltransferase
ID12_01595	COG1131	(ABC) transporter
ID12_01605	COG0148	phosphopyruvate hydratase activity
ID12_01610	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ID12_01615	COG0149	triose-phosphate isomerase activity
ID12_01620	COG0126	phosphoglycerate kinase activity
ID12_01625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ID12_01630	COG2390	Transcriptional regulator
ID12_01635	COG0833	amino acid
ID12_01640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID12_01645	COG3829	transcription factor binding
ID12_01650	COG2186	Transcriptional regulator
ID12_01660	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ID12_01670	COG0534	Mate efflux family protein
ID12_01675	COG4608	Belongs to the ABC transporter superfamily
ID12_01680	COG0444	Belongs to the ABC transporter superfamily
ID12_01685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_01690	COG0601	transmembrane transport
ID12_01695	COG0747	negative chemotaxis
ID12_01700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID12_01705	COG0110	maltose O-acetyltransferase activity
ID12_01710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ID12_01715	COG2244	polysaccharide biosynthetic process
ID12_01720	COG5039	Polysaccharide pyruvyl transferase
ID12_01725	COG1216	Glycosyl transferase, family 2
ID12_01735	COG0438	transferase activity, transferring glycosyl groups
ID12_01740	COG1215	transferase activity, transferring glycosyl groups
ID12_01745	COG0438	transferase activity, transferring glycosyl groups
ID12_01750	COG1086	Polysaccharide biosynthesis protein
ID12_01755	COG0489	protein tyrosine kinase activity
ID12_01760	COG3944	biosynthesis protein
ID12_01765	COG1396	sequence-specific DNA binding
ID12_01775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_01780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_01785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_01790	COG0726	polysaccharide deacetylase
ID12_01800	COG1124	(ABC) transporter
ID12_01815	COG0601	transmembrane transport
ID12_01820	COG0747	negative chemotaxis
ID12_01825	COG1819	glycosyl
ID12_01830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_01850	COG3177	Filamentation induced by cAMP protein fic
ID12_01865	COG0740	serine-type endopeptidase activity
ID12_01870	COG1611	Belongs to the LOG family
ID12_01875	COG1694	Mazg nucleotide pyrophosphohydrolase
ID12_01880	COG0659	secondary active sulfate transmembrane transporter activity
ID12_01885	COG0288	reversible hydration of carbon dioxide
ID12_01895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID12_01905	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ID12_01910	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_01915	COG1481	regulation of sporulation
ID12_01920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ID12_01925	COG1660	Displays ATPase and GTPase activities
ID12_01930	COG1051	belongs to the nudix hydrolase family
ID12_01935	COG0492	ferredoxin-NADP+ reductase activity
ID12_01940	COG0791	NLP P60 protein
ID12_01940	COG3883	PFAM NLP P60 protein
ID12_01945	COG0457	Tetratricopeptide repeat
ID12_01950	COG0140	phosphoribosyl-ATP diphosphatase activity
ID12_01950	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ID12_01955	COG0107	imidazoleglycerol-phosphate synthase activity
ID12_01960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ID12_01965	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ID12_01970	COG0131	Imidazoleglycerol-phosphate dehydratase
ID12_01975	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ID12_01980	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ID12_01985	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ID12_01990	COG4990	cell redox homeostasis
ID12_02005	COG2910	NAD(P)H-binding
ID12_02010	COG1959	2 iron, 2 sulfur cluster binding
ID12_02015	COG0110	maltose O-acetyltransferase activity
ID12_02020	COG0546	phosphoglycolate phosphatase activity
ID12_02025	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ID12_02035	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ID12_02040	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ID12_02045	COG0363	glucosamine-6-phosphate deaminase activity
ID12_02055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ID12_02060	COG1950	PFAM Membrane protein of
ID12_02065	COG1983	PspC domain protein
ID12_02070	COG3595	metallopeptidase activity
ID12_02085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ID12_02095	COG4897	Protein conserved in bacteria
ID12_02100	COG3848	Pyruvate phosphate dikinase
ID12_02100	COG0574	Belongs to the PEP-utilizing enzyme family
ID12_02105	COG1309	transcriptional regulator
ID12_02110	COG2814	Major facilitator Superfamily
ID12_02120	COG0745	RESPONSE REGULATOR receiver
ID12_02125	COG5002	protein histidine kinase activity
ID12_02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ID12_02135	COG0463	Glycosyl transferase, family 2
ID12_02140	COG1113	amino acid transport
ID12_02145	COG0778	Nitroreductase
ID12_02150	COG1733	regulation of RNA biosynthetic process
ID12_02155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_02165	COG0793	Belongs to the peptidase S41A family
ID12_02165	COG3409	Peptidoglycan-binding domain 1 protein
ID12_02170	COG0730	response to heat
ID12_02175	COG0791	NLP P60 protein
ID12_02175	COG3883	PFAM NLP P60 protein
ID12_02180	COG2177	Part of the ABC transporter FtsEX involved in
ID12_02185	COG2884	Cell division ATP-binding protein ftsE
ID12_02190	COG2010	Cytochrome c
ID12_02195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_02210	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
ID12_02215	COG0653	protein targeting
ID12_02220	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ID12_02225	COG0840	transmembrane signaling receptor activity
ID12_02240	COG1516	flagellar protein fliS
ID12_02245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ID12_02250	COG1334	flagellar protein FlaG
ID12_02255	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ID12_02260	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ID12_02270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_02275	COG4786	Flagellar basal body rod
ID12_02275	COG1256	bacterial-type flagellum assembly
ID12_02280	COG3418	PFAM FlgN family protein
ID12_02295	COG1040	competence protein
ID12_02305	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ID12_02310	COG1307	EDD domain protein, DegV family
ID12_02315	COG2197	response regulator
ID12_02320	COG4585	Histidine kinase
ID12_02325	COG1739	Uncharacterized protein family UPF0029
ID12_02330	COG1316	TRANSCRIPTIONal
ID12_02335	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID12_02340	COG0438	transferase activity, transferring glycosyl groups
ID12_02345	COG1215	transferase activity, transferring glycosyl groups
ID12_02350	COG3206	protein involved in exopolysaccharide biosynthesis
ID12_02355	COG3307	-O-antigen
ID12_02360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID12_02365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ID12_02370	COG0297	glycogen (starch) synthase activity
ID12_02370	COG0438	transferase activity, transferring glycosyl groups
ID12_02375	COG2244	polysaccharide biosynthetic process
ID12_02390	COG2247	cell wall binding repeat
ID12_02390	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_02395	COG2247	cell wall binding repeat
ID12_02395	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_02400	COG2385	sporulation resulting in formation of a cellular spore
ID12_02400	COG2247	cell wall binding repeat
ID12_02410	COG1316	TRANSCRIPTIONal
ID12_02415	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ID12_02420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ID12_02425	COG1134	teichoic acid transport
ID12_02430	COG1682	transport, permease protein
ID12_02440	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID12_02450	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ID12_02455	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ID12_02460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID12_02465	COG4193	domain, Protein
ID12_02470	COG1482	cell wall glycoprotein biosynthetic process
ID12_02480	COG1175	transmembrane transport
ID12_02485	COG1653	transport
ID12_02490	COG2197	response regulator
ID12_02495	COG2972	Histidine kinase
ID12_02505	COG0454	-acetyltransferase
ID12_02510	COG0800	Aldolase
ID12_02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ID12_02520	COG1609	Transcriptional regulator
ID12_02525	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ID12_02530	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_02535	COG0697	spore germination
ID12_02540	COG0814	amino acid
ID12_02560	COG2814	Major facilitator Superfamily
ID12_02565	COG1316	TRANSCRIPTIONal
ID12_02570	COG0561	phosphatase activity
ID12_02575	COG0791	NLP P60 protein
ID12_02585	COG2843	Capsule synthesis protein
ID12_02595	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ID12_02600	COG0697	spore germination
ID12_02615	COG1609	Transcriptional regulator
ID12_02620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ID12_02625	COG1869	D-ribose catabolic process
ID12_02630	COG1129	ABC transporter
ID12_02635	COG1172	Belongs to the binding-protein-dependent transport system permease family
ID12_02640	COG1879	ABC-type sugar transport system periplasmic component
ID12_02645	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ID12_02650	COG0583	DNA-binding transcription factor activity
ID12_02655	COG0028	Belongs to the TPP enzyme family
ID12_02660	COG3527	Alpha-acetolactate decarboxylase
ID12_02665	COG1522	sequence-specific DNA binding
ID12_02670	COG2059	Chromate
ID12_02675	COG2059	Chromate
ID12_02680	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ID12_02690	COG4715	Zinc finger, swim domain protein
ID12_02695	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ID12_02700	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_02700	COG2202	Pas domain
ID12_02705	COG0561	phosphatase activity
ID12_02720	COG1970	mechanosensitive ion channel activity
ID12_02725	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ID12_02730	COG0457	Tetratricopeptide repeat
ID12_02735	COG4786	Flagellar basal body rod
ID12_02740	COG4786	Flagellar basal body rod
ID12_02750	COG1077	Cell shape determining protein MreB Mrl
ID12_02755	COG1609	Transcriptional regulator
ID12_02760	COG1846	Transcriptional regulator
ID12_02765	COG2814	Major facilitator Superfamily
ID12_02770	COG0671	phosphoesterase, PA-phosphatase related
ID12_02775	COG0477	Major facilitator Superfamily
ID12_02780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_02785	COG0765	amino acid transport
ID12_02790	COG1126	abc transporter atp-binding protein
ID12_02795	COG0004	ammonium transporteR
ID12_02800	COG0347	Belongs to the P(II) protein family
ID12_02805	COG0739	heme binding
ID12_02810	COG1247	-acetyltransferase
ID12_02845	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID12_02850	COG0523	cobalamin synthesis protein
ID12_02855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID12_02860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ID12_02865	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ID12_02880	COG2304	oxidoreductase activity
ID12_02885	COG2304	oxidoreductase activity
ID12_02890	COG2385	sporulation resulting in formation of a cellular spore
ID12_02895	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID12_02905	COG4836	Membrane
ID12_02915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ID12_02920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ID12_02925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ID12_02930	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ID12_02935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID12_02940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ID12_02945	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ID12_02950	COG0356	it plays a direct role in the translocation of protons across the membrane
ID12_02965	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ID12_02970	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ID12_02975	COG4475	Protein of unknown function (DUF436)
ID12_02980	COG0698	ribose 5-phosphate isomerase
ID12_02985	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID12_02990	COG1971	Probably functions as a manganese efflux pump
ID12_02995	COG0009	L-threonylcarbamoyladenylate synthase
ID12_03000	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ID12_03015	COG2890	protein-(glutamine-N5) methyltransferase activity
ID12_03020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ID12_03025	COG0789	Transcriptional regulator
ID12_03030	COG0679	Auxin Efflux Carrier
ID12_03035	COG0281	malic enzyme
ID12_03040	COG1435	thymidine kinase activity
ID12_03045	COG0254	rRNA binding
ID12_03050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ID12_03055	COG1494	fructose-1,6-bisphosphatase
ID12_03060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ID12_03065	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ID12_03070	COG0191	fructose-bisphosphate aldolase activity
ID12_03075	COG2204	response regulator
ID12_03080	COG4821	SIS domain
ID12_03085	COG0504	CTP synthase activity
ID12_03090	COG3343	RNA polymerase activity
ID12_03105	COG1960	acyl-CoA dehydrogenase activity
ID12_03110	COG1960	acyl-CoA dehydrogenase activity
ID12_03115	COG1250	3-hydroxyacyl-CoA dehydrogenase
ID12_03120	COG0183	Belongs to the thiolase family
ID12_03125	COG2181	nitrate reductase activity
ID12_03125	COG0247	lactate metabolic process
ID12_03130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_03135	COG4294	response to UV
ID12_03145	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID12_03155	COG1132	(ABC) transporter
ID12_03160	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_03165	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID12_03175	COG0018	arginyl-trna synthetase
ID12_03180	COG4506	Protein conserved in bacteria
ID12_03190	COG0010	Belongs to the arginase family
ID12_03195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ID12_03200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_03210	COG1994	Peptidase M50
ID12_03215	COG1942	4-Oxalocrotonate Tautomerase
ID12_03225	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_03230	COG0583	DNA-binding transcription factor activity
ID12_03235	COG0431	NADPH-dependent FMN reductase
ID12_03240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_03245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ID12_03250	COG0454	-acetyltransferase
ID12_03255	COG0765	amino acid transport
ID12_03270	COG1126	abc transporter atp-binding protein
ID12_03275	COG3465	dGTPase activity
ID12_03280	COG1078	dGTPase activity
ID12_03285	COG4844	belongs to the
ID12_03375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
ID12_03385	COG0280	phosphate acetyltransferase
ID12_03395	COG2814	Major facilitator Superfamily
ID12_03400	COG1522	sequence-specific DNA binding
ID12_03405	COG2814	Major facilitator Superfamily
ID12_03410	COG0077	Prephenate dehydratase
ID12_03415	COG1917	Cupin 2, conserved barrel domain protein
ID12_03420	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_03425	COG0151	Belongs to the GarS family
ID12_03430	COG0436	Aminotransferase
ID12_03435	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_03440	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ID12_03445	COG1091	dTDP-4-dehydrorhamnose reductase activity
ID12_03450	COG1088	dTDP-glucose 4,6-dehydratase activity
ID12_03455	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ID12_03460	COG3980	spore coat polysaccharide biosynthesis protein
ID12_03465	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ID12_03470	COG2089	acid synthase
ID12_03475	COG0456	acetyltransferase
ID12_03480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID12_03485	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ID12_03490	COG0463	Glycosyl transferase, family 2
ID12_03510	COG2363	Small membrane protein
ID12_03515	COG2233	PERMEase
ID12_03525	COG1012	belongs to the aldehyde dehydrogenase family
ID12_03530	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ID12_03535	COG1216	Glycosyl transferase, family 2
ID12_03545	COG0351	phosphomethylpyrimidine kinase
ID12_03560	COG1621	beta-fructofuranosidase activity
ID12_03565	COG1263	PTS System
ID12_03565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_03570	COG3711	transcriptional antiterminator
ID12_03580	COG1404	Belongs to the peptidase S8 family
ID12_03590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_03595	COG0778	Nitroreductase
ID12_03600	COG0772	Belongs to the SEDS family
ID12_03610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ID12_03615	COG1845	cytochrome c oxidase, subunit III
ID12_03620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ID12_03625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ID12_03635	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ID12_03640	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ID12_03645	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ID12_03660	COG2246	polysaccharide biosynthetic process
ID12_03680	COG3162	membrane
ID12_03685	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID12_03710	COG0352	thiamine-phosphate diphosphorylase activity
ID12_03715	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ID12_03720	COG0583	DNA-binding transcription factor activity
ID12_03725	COG1380	Effector of murein hydrolase LrgA
ID12_03730	COG1346	cytolysis
ID12_03735	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ID12_03740	COG0346	lactoylglutathione lyase activity
ID12_03750	COG0765	amino acid transport
ID12_03755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_03765	COG0457	Tetratricopeptide repeat
ID12_03775	COG2357	RelA SpoT domain protein
ID12_03780	COG1172	Belongs to the binding-protein-dependent transport system permease family
ID12_03785	COG1129	ABC transporter
ID12_03795	COG3420	alginic acid biosynthetic process
ID12_03800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_03815	COG1486	melibiose metabolic process
ID12_03820	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID12_03825	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_03830	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_03835	COG3711	transcriptional antiterminator
ID12_03835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_03855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID12_03870	COG1595	DNA-templated transcription, initiation
ID12_03875	COG3866	Pectate lyase
ID12_03880	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ID12_03885	COG4988	ABC transporter
ID12_03890	COG1294	oxidase, subunit
ID12_03895	COG1271	oxidase subunit
ID12_03900	COG1120	ATPase activity
ID12_03905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_03910	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ID12_03915	COG4509	Sortase family
ID12_03940	COG5386	Cell surface protein
ID12_03945	COG5386	Cell surface protein
ID12_03955	COG1733	regulation of RNA biosynthetic process
ID12_03960	COG2514	catechol 2,3-dioxygenase activity
ID12_03965	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_03965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_03970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_03970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_03985	COG0726	polysaccharide deacetylase
ID12_03990	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID12_03995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_04000	COG2723	6-phospho-beta-galactosidase activity
ID12_04005	COG1312	Catalyzes the dehydration of D-mannonate
ID12_04015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_04020	COG3711	transcriptional antiterminator
ID12_04020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_04045	COG1757	Na H antiporter
ID12_04050	COG1027	Aspartate ammonia-lyase
ID12_04055	COG0252	asparaginase activity
ID12_04060	COG1396	sequence-specific DNA binding
ID12_04085	COG4842	Belongs to the WXG100 family
ID12_04090	COG2195	Cleaves the N-terminal amino acid of tripeptides
ID12_04105	COG1737	Transcriptional regulator
ID12_04110	COG2084	Dehydrogenase
ID12_04120	COG2610	gluconate transmembrane transporter activity
ID12_04125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ID12_04135	COG1136	(ABC) transporter
ID12_04140	COG2723	6-phospho-beta-galactosidase activity
ID12_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_04145	COG1263	PTS System
ID12_04145	COG2190	(PTS) system
ID12_04150	COG3711	transcriptional antiterminator
ID12_04155	COG3878	Protein conserved in bacteria
ID12_04165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ID12_04170	COG1122	ATPase activity
ID12_04175	COG4721	ABC-type cobalt transport system, permease component
ID12_04180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ID12_04210	COG3291	Pkd domain containing protein
ID12_04210	COG4412	M6 family metalloprotease domain protein
ID12_04215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ID12_04220	COG0778	Nitroreductase
ID12_04225	COG1846	Transcriptional regulator
ID12_04235	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ID12_04240	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ID12_04245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ID12_04250	COG2390	Transcriptional regulator
ID12_04260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ID12_04260	COG2755	lipolytic protein G-D-S-L family
ID12_04265	COG0477	Major facilitator Superfamily
ID12_04275	COG2226	methyltransferase
ID12_04285	COG0561	phosphatase activity
ID12_04290	COG0789	Transcriptional regulator
ID12_04295	COG0673	inositol 2-dehydrogenase activity
ID12_04300	COG0840	transmembrane signaling receptor activity
ID12_04310	COG1113	amino acid transport
ID12_04315	COG4335	DNA alkylation repair
ID12_04325	COG1070	Carbohydrate kinase
ID12_04330	COG1737	Transcriptional regulator
ID12_04370	COG0583	DNA-binding transcription factor activity
ID12_04375	COG1609	Transcriptional regulator
ID12_04380	COG2182	Extracellular solute-binding protein
ID12_04385	COG1175	transmembrane transport
ID12_04390	COG3833	ABC-type maltose transport systems, permease component
ID12_04400	COG1874	Beta-galactosidase
ID12_04405	COG2851	Citrate transporter
ID12_04415	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ID12_04420	COG1131	(ABC) transporter
ID12_04425	COG2824	Alkylphosphonate utilization operon protein PhnA
ID12_04430	COG1929	Belongs to the glycerate kinase type-1 family
ID12_04435	COG2610	gluconate transmembrane transporter activity
ID12_04440	COG3835	regulator
ID12_04445	COG1309	transcriptional regulator
ID12_04450	COG2814	Major facilitator Superfamily
ID12_04460	COG1136	(ABC) transporter
ID12_04470	COG0457	Tetratricopeptide repeat
ID12_04475	COG3711	transcriptional antiterminator
ID12_04480	COG2723	6-phospho-beta-galactosidase activity
ID12_04485	COG1263	PTS System
ID12_04485	COG2190	(PTS) system
ID12_04485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_04510	COG0494	nUDIX hydrolase
ID12_04525	COG1113	amino acid transport
ID12_04535	COG2814	Major facilitator Superfamily
ID12_04540	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ID12_04545	COG2814	Major facilitator Superfamily
ID12_04585	COG2723	6-phospho-beta-galactosidase activity
ID12_04590	COG2190	(PTS) system
ID12_04590	COG1263	PTS System
ID12_04590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_04595	COG2188	Transcriptional regulator
ID12_04610	COG0384	phenazine biosynthesis protein PhzF
ID12_04615	COG0583	DNA-binding transcription factor activity
ID12_04635	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ID12_04675	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ID12_04685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ID12_04695	COG4720	Psort location CytoplasmicMembrane, score
ID12_04715	COG0456	acetyltransferase
ID12_04720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_04725	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ID12_04730	COG4853	Protein conserved in bacteria
ID12_04735	COG4863	YycH protein
ID12_04740	COG5002	protein histidine kinase activity
ID12_04745	COG0745	RESPONSE REGULATOR receiver
ID12_04770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ID12_04780	COG2311	Membrane
ID12_04785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ID12_04790	COG1309	transcriptional regulator
ID12_04795	COG2124	cytochrome p450
ID12_04800	COG0346	lactoylglutathione lyase activity
ID12_04805	COG0305	Participates in initiation and elongation during chromosome replication
ID12_04825	COG2819	hydrolase of the alpha beta superfamily
ID12_04830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_04830	COG2207	Transcriptional regulator
ID12_04835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_04840	COG2819	hydrolase of the alpha beta superfamily
ID12_04850	COG2807	transmembrane transport
ID12_04855	COG0359	binds to the 23S rRNA
ID12_04860	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ID12_04865	COG4241	membrane
ID12_04870	COG1227	inorganic diphosphatase activity
ID12_04880	COG1595	DNA-templated transcription, initiation
ID12_04890	COG0753	catalase activity
ID12_04895	COG0655	NAD(P)H dehydrogenase (quinone) activity
ID12_04900	COG0400	carboxylic ester hydrolase activity
ID12_04905	COG0346	lactoylglutathione lyase activity
ID12_04910	COG1174	glycine betaine transport
ID12_04915	COG0517	IMP dehydrogenase activity
ID12_04915	COG1125	glycine betaine transport
ID12_04920	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ID12_04925	COG0629	single-stranded DNA binding
ID12_04930	COG0360	Binds together with S18 to 16S ribosomal RNA
ID12_04935	COG0012	GTP binding
ID12_04940	COG4481	Protein conserved in bacteria
ID12_04955	COG3949	Membrane
ID12_04965	COG1475	DNA binding
ID12_04970	COG1192	Involved in chromosome partitioning
ID12_04980	COG1475	DNA binding
ID12_04985	COG0357	Ribosomal RNA small subunit methyltransferase G
ID12_04990	COG0445	tRNA wobble uridine modification
ID12_04995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ID12_05000	COG1847	R3H domain protein
ID12_05005	COG0706	membrane insertase activity
ID12_05010	COG0594	ribonuclease P activity
ID12_05020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ID12_05025	COG0592	DNA-directed DNA polymerase activity
ID12_05030	COG2501	S4 domain
ID12_05035	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ID12_05045	COG0187	DNA topoisomerase II activity
ID12_05050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ID12_05090	COG0517	IMP dehydrogenase activity
ID12_05090	COG0516	GMP reductase activity
ID12_05095	COG1686	Belongs to the peptidase S11 family
ID12_05100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_05105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ID12_05110	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ID12_05115	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ID12_05120	COG0840	transmembrane signaling receptor activity
ID12_05130	COG1428	Deoxynucleoside kinase
ID12_05135	COG1428	Deoxynucleoside kinase
ID12_05140	COG3858	chitin binding
ID12_05140	COG1388	LysM domain
ID12_05145	COG1335	isochorismatase
ID12_05150	COG0590	tRNA wobble adenosine to inosine editing
ID12_05155	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ID12_05160	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ID12_05165	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ID12_05210	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ID12_05215	COG3853	Toxic anion resistance protein (TelA)
ID12_05220	COG1982	Orn Lys Arg decarboxylase major
ID12_05225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ID12_05230	COG3870	Protein conserved in bacteria
ID12_05235	COG1728	Protein conserved in bacteria
ID12_05240	COG0470	DNA polymerase III
ID12_05245	COG1774	PSP1 C-terminal conserved region
ID12_05250	COG4467	Involved in initiation control of chromosome replication
ID12_05255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ID12_05260	COG2827	Endonuclease containing a URI domain
ID12_05265	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ID12_05270	COG2002	toxin-antitoxin pair type II binding
ID12_05275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_05275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_05280	COG0084	hydrolase, TatD family'
ID12_05285	COG3584	3D domain protein
ID12_05285	COG3583	domain protein
ID12_05290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ID12_05295	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ID12_05305	COG4466	Protein conserved in bacteria
ID12_05315	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ID12_05320	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID12_05325	COG0251	oxidation-reduction process
ID12_05330	COG2088	sporulation resulting in formation of a cellular spore
ID12_05340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ID12_05345	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ID12_05350	COG0193	aminoacyl-tRNA hydrolase activity
ID12_05360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ID12_05365	COG2002	toxin-antitoxin pair type II binding
ID12_05370	COG2244	polysaccharide biosynthetic process
ID12_05375	COG3956	TIGRFAM MazG family protein
ID12_05380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ID12_05395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ID12_05400	COG1098	S1 RNA binding domain
ID12_05420	COG2208	phosphoserine phosphatase activity
ID12_05425	COG2304	oxidoreductase activity
ID12_05430	COG0515	serine threonine protein kinase
ID12_05435	COG0037	tRNA processing
ID12_05445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ID12_05450	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ID12_05455	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ID12_05460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID12_05465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_05470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ID12_05475	COG0512	Glutamine amidotransferase of anthranilate synthase
ID12_05480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_05485	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ID12_05490	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ID12_05495	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ID12_05500	COG1396	sequence-specific DNA binding
ID12_05505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ID12_05510	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ID12_05590	COG4463	regulation of RNA biosynthetic process
ID12_05595	COG3880	PFAM UvrB UvrC protein
ID12_05600	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ID12_05605	COG0542	response to heat
ID12_05610	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ID12_05615	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ID12_05620	COG4956	integral membrane protein (PIN domain superfamily)
ID12_05625	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ID12_05630	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ID12_05635	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ID12_05640	COG1045	serine acetyltransferase
ID12_05645	COG0215	cysteine-tRNA ligase activity
ID12_05650	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ID12_05655	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID12_05660	COG3688	RNA-binding protein containing a PIN domain
ID12_05665	COG1595	DNA-templated transcription, initiation
ID12_05670	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ID12_05675	COG0250	Participates in transcription elongation, termination and antitermination
ID12_05680	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ID12_05685	COG0081	regulation of translation
ID12_05690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ID12_05695	COG0222	ribosome binding
ID12_05700	COG2813	Specifically methylates the guanine in position
ID12_05705	COG0085	RNA polymerase activity
ID12_05710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ID12_05715	COG1358	cellular component organization or biogenesis
ID12_05720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ID12_05725	COG0049	tRNA binding
ID12_05730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ID12_05735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ID12_05740	COG0596	Alpha beta hydrolase
ID12_05745	COG0051	transcription antitermination factor activity, RNA binding
ID12_05750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ID12_05755	COG0088	Forms part of the polypeptide exit tunnel
ID12_05760	COG0089	rRNA binding
ID12_05765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ID12_05770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ID12_05775	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ID12_05780	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ID12_05785	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ID12_05790	COG0255	Belongs to the universal ribosomal protein uL29 family
ID12_05795	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ID12_05800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ID12_05805	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ID12_05810	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ID12_05815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ID12_05820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ID12_05825	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ID12_05830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ID12_05835	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ID12_05840	COG1841	ribosomal large subunit assembly
ID12_05845	COG0200	Binds to the 23S rRNA
ID12_05850	COG0201	protein transport
ID12_05855	COG0563	adenylate kinase activity
ID12_05860	COG0024	Methionine aminopeptidase
ID12_05865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ID12_05870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ID12_05875	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ID12_05880	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ID12_05885	COG0202	RNA polymerase activity
ID12_05890	COG0203	ribosomal protein L17
ID12_05895	COG1122	ATPase activity
ID12_05900	COG1122	ATPase activity
ID12_05905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ID12_05910	COG0101	tRNA pseudouridine synthase activity
ID12_05915	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ID12_05920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ID12_05925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_05950	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_05955	COG0489	protein tyrosine kinase activity
ID12_05965	COG2194	sulfuric ester hydrolase activity
ID12_05970	COG0726	polysaccharide deacetylase
ID12_06000	COG0659	secondary active sulfate transmembrane transporter activity
ID12_06005	COG0385	Bile acid
ID12_06010	COG3876	Protein conserved in bacteria
ID12_06015	COG1472	Belongs to the glycosyl hydrolase 3 family
ID12_06020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ID12_06025	COG1263	PTS System
ID12_06025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_06030	COG1737	Transcriptional regulator
ID12_06035	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ID12_06070	COG1595	DNA-templated transcription, initiation
ID12_06075	COG5662	AntiSigma factor
ID12_06080	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ID12_06085	COG4856	YbbR-like protein
ID12_06090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID12_06095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ID12_06115	COG1131	(ABC) transporter
ID12_06125	COG1136	(ABC) transporter
ID12_06155	COG3402	PFAM membrane-flanked domain
ID12_06160	COG1131	(ABC) transporter
ID12_06210	COG2311	Membrane
ID12_06230	COG1476	TRANSCRIPTIONal
ID12_06240	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ID12_06245	COG2207	Transcriptional regulator
ID12_06250	COG1309	transcriptional regulator
ID12_06270	COG1113	amino acid transport
ID12_06275	COG0584	glycerophosphoryl diester phosphodiesterase
ID12_06280	COG2271	Major facilitator Superfamily
ID12_06290	COG1331	Highly conserved protein containing a thioredoxin domain
ID12_06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID12_06310	COG0640	Transcriptional regulator
ID12_06325	COG1937	Protein conserved in bacteria
ID12_06330	COG2210	Belongs to the sulfur carrier protein TusA family
ID12_06340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_06340	COG0425	Belongs to the sulfur carrier protein TusA family
ID12_06345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_06345	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_06350	COG0425	Belongs to the sulfur carrier protein TusA family
ID12_06355	COG0730	response to heat
ID12_06365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID12_06370	COG2814	Major facilitator Superfamily
ID12_06385	COG1846	Transcriptional regulator
ID12_06395	COG1683	Conserved Protein
ID12_06400	COG0656	L-ascorbic acid biosynthetic process
ID12_06405	COG0371	Dehydrogenase
ID12_06415	COG0531	amino acid
ID12_06425	COG3711	transcriptional antiterminator
ID12_06430	COG2190	(PTS) system
ID12_06430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_06430	COG1263	PTS System
ID12_06435	COG2723	6-phospho-beta-galactosidase activity
ID12_06450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_06450	COG3711	transcriptional antiterminator
ID12_06455	COG1940	carbohydrate kinase activity
ID12_06460	COG0383	alpha-mannosidase activity
ID12_06465	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_06470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_06475	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_06475	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_06480	COG1404	Belongs to the peptidase S8 family
ID12_06495	COG0833	amino acid
ID12_06500	COG2040	homocysteine
ID12_06505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_06510	COG1695	Transcriptional regulator
ID12_06525	COG2814	Major facilitator Superfamily
ID12_06545	COG1404	Belongs to the peptidase S8 family
ID12_06555	COG1309	transcriptional regulator
ID12_06560	COG1917	Cupin 2, conserved barrel domain protein
ID12_06565	COG1063	alcohol dehydrogenase
ID12_06570	COG1846	Transcriptional regulator
ID12_06575	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_06580	COG0531	amino acid
ID12_06590	COG0596	Alpha beta hydrolase
ID12_06595	COG1115	amino acid carrier protein
ID12_06600	COG2066	Belongs to the glutaminase family
ID12_06605	COG4191	Histidine kinase
ID12_06610	COG0784	Response regulator, receiver
ID12_06615	COG3012	SEC-C Motif Domain Protein
ID12_06615	COG1405	negative regulation of cell septum assembly
ID12_06625	COG0667	Aldo Keto reductase
ID12_06630	COG3290	protein histidine kinase activity
ID12_06635	COG3279	Response regulator of the LytR AlgR family
ID12_06640	COG4555	ABC transporter
ID12_06645	COG1668	transmembrane transport
ID12_06665	COG3773	Cell wall hydrolase
ID12_06670	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_06680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_06685	COG2310	stress, protein
ID12_06690	COG2310	stress, protein
ID12_06695	COG2310	stress, protein
ID12_06700	COG0861	Integral membrane protein TerC family
ID12_06730	COG3853	Toxic anion resistance protein (TelA)
ID12_06735	COG0517	IMP dehydrogenase activity
ID12_06735	COG4175	Glycine betaine
ID12_06740	COG4176	ABC-type proline glycine betaine transport system permease component
ID12_06745	COG2113	Glycine betaine
ID12_06760	COG1473	amidohydrolase
ID12_06765	COG1288	antiporter activity
ID12_06770	COG0039	L-malate dehydrogenase activity
ID12_06775	COG1620	l-lactate permease
ID12_06780	COG1609	Transcriptional regulator
ID12_06785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ID12_06790	COG0561	phosphatase activity
ID12_06795	COG0673	inositol 2-dehydrogenase activity
ID12_06800	COG0738	Major facilitator superfamily
ID12_06805	COG1280	lysine exporter protein (LysE YggA)
ID12_06825	COG3403	YqcI/YcgG family
ID12_06830	COG1113	amino acid transport
ID12_06835	COG3665	Urea carboxylase-associated protein
ID12_06840	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ID12_06870	COG1012	belongs to the aldehyde dehydrogenase family
ID12_06875	COG0710	3-dehydroquinate dehydratase activity
ID12_06880	COG0028	Belongs to the TPP enzyme family
ID12_06890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
ID12_06895	COG2271	Major facilitator Superfamily
ID12_06905	COG1414	Transcriptional regulator
ID12_06910	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ID12_06915	COG2226	methyltransferase
ID12_06920	COG0583	DNA-binding transcription factor activity
ID12_06925	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID12_06930	COG3458	cephalosporin-C deacetylase activity
ID12_06940	COG3541	Predicted nucleotidyltransferase
ID12_06945	COG0506	proline dehydrogenase activity
ID12_06950	COG1012	belongs to the aldehyde dehydrogenase family
ID12_06955	COG2508	Transcriptional regulator
ID12_06960	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ID12_06965	COG0765	amino acid transport
ID12_06970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_06980	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ID12_06985	COG1522	sequence-specific DNA binding
ID12_06990	COG2746	aminoglycoside 3-N-acetyltransferase activity
ID12_07000	COG3290	protein histidine kinase activity
ID12_07000	COG0840	transmembrane signaling receptor activity
ID12_07005	COG3209	COG3209 Rhs family protein
ID12_07030	COG3842	ATPase activity
ID12_07035	COG1176	ABC-type spermidine putrescine transport system, permease component I
ID12_07045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID12_07050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID12_07055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ID12_07070	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ID12_07085	COG4555	ABC transporter
ID12_07100	COG0697	spore germination
ID12_07105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_07115	COG3708	Transcriptional regulator
ID12_07115	COG2207	Transcriptional regulator
ID12_07125	COG2364	Membrane
ID12_07130	COG1126	abc transporter atp-binding protein
ID12_07135	COG0765	amino acid transport
ID12_07140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_07145	COG0412	Dienelactone hydrolase
ID12_07150	COG0833	amino acid
ID12_07155	COG3104	oligopeptide transport
ID12_07160	COG5434	Belongs to the glycosyl hydrolase 28 family
ID12_07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_07180	COG0765	amino acid transport
ID12_07185	COG1126	abc transporter atp-binding protein
ID12_07195	COG2079	MmgE PrpD family protein
ID12_07200	COG0745	RESPONSE REGULATOR receiver
ID12_07205	COG3850	Histidine kinase
ID12_07205	COG5002	protein histidine kinase activity
ID12_07210	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_07215	COG0527	aspartate kinase activity
ID12_07220	COG2814	Major facilitator Superfamily
ID12_07225	COG1309	transcriptional regulator
ID12_07235	COG0640	Transcriptional regulator
ID12_07245	COG0583	DNA-binding transcription factor activity
ID12_07250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_07255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ID12_07260	COG0531	amino acid
ID12_07265	COG1012	belongs to the aldehyde dehydrogenase family
ID12_07270	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID12_07275	COG4549	nuclear export factor GLE1
ID12_07280	COG2372	response to copper ion
ID12_07280	COG1276	copper resistance
ID12_07285	COG2213	PTS system mannitol-specific
ID12_07290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_07295	COG0246	Mannitol dehydrogenase
ID12_07300	COG0840	transmembrane signaling receptor activity
ID12_07335	COG0346	lactoylglutathione lyase activity
ID12_07345	COG0561	phosphatase activity
ID12_07350	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ID12_07355	COG1914	H( )-stimulated, divalent metal cation uptake system
ID12_07360	COG4336	lyase activity
ID12_07365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ID12_07370	COG1984	allophanate hydrolase subunit 2
ID12_07375	COG1414	Transcriptional regulator
ID12_07380	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID12_07390	COG2755	lipolytic protein G-D-S-L family
ID12_07400	COG3711	transcriptional antiterminator
ID12_07405	COG2226	methyltransferase
ID12_07410	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_07420	COG3871	stress protein (general stress protein 26)
ID12_07440	COG2814	Major facilitator Superfamily
ID12_07445	COG1802	Transcriptional regulator
ID12_07460	COG0473	3-isopropylmalate dehydrogenase activity
ID12_07465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ID12_07465	COG0551	DNA topoisomerase type I activity
ID12_07470	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ID12_07475	COG3706	GGDEF domain
ID12_07480	COG5298	Protein conserved in bacteria
ID12_07485	COG1215	transferase activity, transferring glycosyl groups
ID12_07495	COG0531	amino acid
ID12_07500	COG0028	Belongs to the TPP enzyme family
ID12_07545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_07550	COG1914	H( )-stimulated, divalent metal cation uptake system
ID12_07555	COG2261	transglycosylase associated protein
ID12_07560	COG2217	Heavy metal translocating P-type atpase
ID12_07565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ID12_07570	COG3290	protein histidine kinase activity
ID12_07575	COG4565	transcriptional regulatory protein
ID12_07580	COG1301	dicarboxylic acid transport
ID12_07585	COG0628	permease
ID12_07590	COG1301	dicarboxylic acid transport
ID12_07595	COG1131	(ABC) transporter
ID12_07600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ID12_07615	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_07620	COG1181	Belongs to the D-alanine--D-alanine ligase family
ID12_07625	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ID12_07640	COG0513	Belongs to the DEAD box helicase family
ID12_07645	COG3402	PFAM membrane-flanked domain
ID12_07650	COG3428	Bacterial PH domain
ID12_07655	COG0705	Rhomboid family
ID12_07660	COG0736	holo-[acyl-carrier-protein] synthase activity
ID12_07665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ID12_07670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ID12_07675	COG0864	Transcriptional regulator
ID12_07680	COG2337	Toxic component of a toxin-antitoxin (TA) module
ID12_07685	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_07690	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_07695	COG2172	sigma factor antagonist activity
ID12_07700	COG2208	phosphoserine phosphatase activity
ID12_07705	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_07710	COG2172	sigma factor antagonist activity
ID12_07715	COG1191	sigma factor activity
ID12_07720	COG2208	phosphoserine phosphatase activity
ID12_07725	COG2183	response to ionizing radiation
ID12_07735	COG3091	SprT-like family
ID12_07775	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ID12_07785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_07800	COG1278	Cold shock
ID12_07805	COG1329	Transcriptional regulator
ID12_07810	COG1064	alcohol dehydrogenase
ID12_07815	COG0789	Transcriptional regulator
ID12_07830	COG0477	Major facilitator Superfamily
ID12_07850	COG4221	oxidoreductase activity
ID12_07860	COG0252	asparaginase activity
ID12_07880	COG2814	Major facilitator Superfamily
ID12_07925	COG1309	transcriptional regulator
ID12_07930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID12_07935	COG1846	Transcriptional regulator
ID12_07940	COG0778	Nitroreductase
ID12_07960	COG1396	sequence-specific DNA binding
ID12_07970	COG0456	acetyltransferase
ID12_07980	COG4122	O-methyltransferase activity
ID12_07990	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ID12_07995	COG0697	spore germination
ID12_08005	COG1301	dicarboxylic acid transport
ID12_08050	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ID12_08055	COG0802	atpase or kinase
ID12_08060	COG1214	PFAM Peptidase M22, glycoprotease
ID12_08065	COG0456	acetyltransferase
ID12_08070	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ID12_08075	COG0488	(ABC) transporter
ID12_08080	COG0315	cyclic pyranopterin monophosphate synthase activity
ID12_08085	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ID12_08090	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ID12_08095	COG0805	protein transport
ID12_08110	COG1266	CAAX protease self-immunity
ID12_08115	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ID12_08120	COG0459	protein refolding
ID12_08125	COG1846	Transcriptional regulator
ID12_08130	COG2808	Putative FMN-binding domain
ID12_08135	COG1876	peptidase activity
ID12_08160	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ID12_08165	COG0823	Involved in the tonB-independent uptake of proteins
ID12_08175	COG2132	Multicopper oxidase
ID12_08180	COG1113	amino acid transport
ID12_08185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ID12_08190	COG0714	Associated with various cellular activities
ID12_08195	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ID12_08200	COG1305	Transglutaminase-like
ID12_08205	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ID12_08205	COG0519	Catalyzes the synthesis of GMP from XMP
ID12_08235	COG1595	DNA-templated transcription, initiation
ID12_08245	COG2814	Major facilitator Superfamily
ID12_08250	COG0583	DNA-binding transcription factor activity
ID12_08255	COG2252	PERMEase
ID12_08265	COG5583	Uncharacterized small protein (DUF2292)
ID12_08270	COG3064	Membrane
ID12_08275	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ID12_08285	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ID12_08290	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ID12_08295	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ID12_08300	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ID12_08305	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ID12_08310	COG0047	phosphoribosylformylglycinamidine synthase activity
ID12_08315	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ID12_08320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ID12_08325	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ID12_08330	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ID12_08335	COG0138	bifunctional purine biosynthesis protein purh
ID12_08340	COG0151	Belongs to the GarS family
ID12_08360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ID12_08365	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ID12_08370	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ID12_08375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID12_08385	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ID12_08390	COG4496	protein, YerC YecD
ID12_08400	COG0069	glutamate synthase activity
ID12_08415	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ID12_08420	COG0210	DNA helicase
ID12_08425	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ID12_08430	COG4851	CamS sex pheromone cAM373 precursor
ID12_08440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ID12_08445	COG1285	pathogenesis
ID12_08450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID12_08455	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID12_08460	COG0154	amidase activity
ID12_08465	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ID12_08470	COG1309	transcriptional regulator
ID12_08475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID12_08480	COG1957	nucleoside hydrolase
ID12_08485	COG1597	lipid kinase activity
ID12_08490	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID12_08495	COG1122	ATPase activity
ID12_08505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ID12_08520	COG1959	2 iron, 2 sulfur cluster binding
ID12_08525	COG0492	ferredoxin-NADP+ reductase activity
ID12_08540	COG1486	melibiose metabolic process
ID12_08550	COG2211	Major facilitator Superfamily
ID12_08580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ID12_08585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID12_08590	COG1442	glycosyl transferase family 8
ID12_08595	COG1216	Glycosyl transferase, family 2
ID12_08600	COG1442	glycosyl transferase family 8
ID12_08605	COG2223	nitrite transmembrane transporter activity
ID12_08620	COG0471	metal ion transport
ID12_08635	COG0071	Belongs to the small heat shock protein (HSP20) family
ID12_08650	COG0531	amino acid
ID12_08655	COG0457	Tetratricopeptide repeat
ID12_08655	COG0463	Glycosyl transferase, family 2
ID12_08660	COG0488	(ABC) transporter
ID12_08665	COG1469	GTP cyclohydrolase I activity
ID12_08670	COG0789	Transcriptional regulator
ID12_08675	COG2814	Major facilitator Superfamily
ID12_08680	COG0488	(ABC) transporter
ID12_08685	COG0513	Belongs to the DEAD box helicase family
ID12_08690	COG2130	NADP-dependent
ID12_08715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_08715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_08720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID12_08730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_08730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ID12_08740	COG3290	protein histidine kinase activity
ID12_08745	COG4565	transcriptional regulatory protein
ID12_08750	COG3181	Tripartite tricarboxylate transporter family receptor
ID12_08760	COG2851	Citrate transporter
ID12_08770	COG3479	Phenolic acid decarboxylase
ID12_08775	COG1695	Transcriptional regulator
ID12_08780	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ID12_08790	COG1254	Belongs to the acylphosphatase family
ID12_08795	COG2258	MOSC domain
ID12_08810	COG0024	Methionine aminopeptidase
ID12_08815	COG1263	PTS System
ID12_08815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_08820	COG3739	integral membrane protein
ID12_08835	COG1368	sulfuric ester hydrolase activity
ID12_08840	COG0076	glutamate decarboxylase activity
ID12_08845	COG0840	transmembrane signaling receptor activity
ID12_08855	COG1263	PTS System
ID12_08855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_08860	COG0366	Alpha amylase catalytic
ID12_08865	COG2188	Transcriptional regulator
ID12_08875	COG0737	Belongs to the 5'-nucleotidase family
ID12_08880	COG0693	protein deglycase activity
ID12_08885	COG4840	Belongs to the UPF0435 family
ID12_08890	COG1115	amino acid carrier protein
ID12_08895	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID12_08900	COG4980	gas vesicle protein
ID12_08905	COG1295	ribonuclease BN
ID12_08915	COG0477	Major facilitator Superfamily
ID12_08925	COG0387	Pfam Sodium calcium exchanger
ID12_08935	COG0217	transcriptional regulatory protein
ID12_08945	COG0668	transmembrane transport
ID12_08950	COG0535	radical SAM domain protein
ID12_08960	COG0726	polysaccharide deacetylase
ID12_08970	COG0598	Magnesium transport protein CorA
ID12_08980	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ID12_08985	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ID12_09020	COG0789	Transcriptional regulator
ID12_09025	COG2814	Major facilitator Superfamily
ID12_09040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID12_09100	COG2076	Multidrug Resistance protein
ID12_09105	COG2076	Multidrug Resistance protein
ID12_09110	COG1309	transcriptional regulator
ID12_09120	COG4637	Psort location Cytoplasmic, score
ID12_09125	COG2755	lipolytic protein G-D-S-L family
ID12_09130	COG0492	ferredoxin-NADP+ reductase activity
ID12_09135	COG2169	Transcriptional regulator
ID12_09140	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ID12_09145	COG1132	(ABC) transporter
ID12_09150	COG1742	UPF0060 membrane protein
ID12_09155	COG1595	DNA-templated transcription, initiation
ID12_09180	COG2318	DinB family
ID12_09190	COG1846	Transcriptional regulator
ID12_09195	COG0392	lysyltransferase activity
ID12_09195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ID12_09215	COG0778	Nitroreductase
ID12_09230	COG1090	epimerase
ID12_09235	COG2137	regulation of response to DNA damage stimulus
ID12_09260	COG0463	Glycosyl transferase, family 2
ID12_09265	COG4485	Bacterial membrane protein, YfhO
ID12_09270	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ID12_09285	COG2140	Oxalate decarboxylase
ID12_09295	COG1191	sigma factor activity
ID12_09305	COG1988	membrane-bound metal-dependent
ID12_09310	COG1194	a g-specific adenine glycosylase
ID12_09320	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_09335	COG3557	Belongs to the UPF0374 family
ID12_09340	COG1132	(ABC) transporter
ID12_09345	COG0444	Belongs to the ABC transporter superfamily
ID12_09350	COG4608	Belongs to the ABC transporter superfamily
ID12_09355	COG0747	negative chemotaxis
ID12_09370	COG4129	membrane
ID12_09375	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ID12_09380	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ID12_09385	COG0735	belongs to the Fur family
ID12_09535	COG1368	sulfuric ester hydrolase activity
ID12_09540	COG0681	Belongs to the peptidase S26 family
ID12_09555	COG1116	anion transmembrane transporter activity
ID12_09560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ID12_09565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ID12_09570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_09585	COG1131	(ABC) transporter
ID12_09615	COG3382	B3 4 domain protein
ID12_09620	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ID12_09630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ID12_09650	COG2766	serine protein kinase
ID12_09655	COG2718	Belongs to the UPF0229 family
ID12_09660	COG1566	PFAM secretion protein HlyD family protein
ID12_09665	COG2814	Major facilitator Superfamily
ID12_09670	COG0655	NAD(P)H dehydrogenase (quinone) activity
ID12_09680	COG1278	Cold shock
ID12_09685	COG3706	GGDEF domain
ID12_09710	COG5577	PFAM Coat F domain
ID12_09715	COG5002	protein histidine kinase activity
ID12_09720	COG4085	toxin activity
ID12_09720	COG1525	nuclease
ID12_09720	COG0737	Belongs to the 5'-nucleotidase family
ID12_09725	COG3764	Sortase (surface protein transpeptidase)
ID12_09730	COG0564	pseudouridine synthase activity
ID12_09745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ID12_09750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ID12_09750	COG3153	acetyltransferase
ID12_09770	COG3835	regulator
ID12_09775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ID12_09780	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ID12_09785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ID12_09790	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ID12_09795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ID12_09800	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ID12_09805	COG2203	Gaf domain
ID12_09805	COG4585	Histidine kinase
ID12_09810	COG2197	response regulator
ID12_09825	COG0753	catalase activity
ID12_09830	COG1959	2 iron, 2 sulfur cluster binding
ID12_09835	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ID12_09835	COG1017	nitric oxide dioxygenase activity
ID12_09840	COG2719	SpoVR family
ID12_09845	COG1785	Belongs to the alkaline phosphatase family
ID12_09850	COG1388	LysM domain
ID12_09850	COG0791	NLP P60 protein
ID12_09855	COG0531	amino acid
ID12_09870	COG1595	DNA-templated transcription, initiation
ID12_09875	COG0204	Acyl-transferase
ID12_09880	COG1253	flavin adenine dinucleotide binding
ID12_09885	COG0789	Transcriptional regulator
ID12_09890	COG1253	flavin adenine dinucleotide binding
ID12_09905	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ID12_09910	COG0584	glycerophosphoryl diester phosphodiesterase
ID12_09920	COG0668	transmembrane transport
ID12_09925	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ID12_09930	COG0726	polysaccharide deacetylase
ID12_09935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_09940	COG0589	response to stress
ID12_09955	COG1132	(ABC) transporter
ID12_09960	COG1132	(ABC) transporter
ID12_09975	COG0702	epimerase
ID12_09990	COG3842	ATPase activity
ID12_09995	COG2508	Transcriptional regulator
ID12_10005	COG0189	ligase activity
ID12_10010	COG0189	ligase activity
ID12_10015	COG4399	Belongs to the UPF0754 family
ID12_10020	COG3679	Belongs to the UPF0342 family
ID12_10025	COG0561	phosphatase activity
ID12_10030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ID12_10040	COG0475	glutathione-regulated potassium exporter activity
ID12_10045	COG0490	domain, Protein
ID12_10055	COG1024	Enoyl-CoA hydratase
ID12_10065	COG0420	3'-5' exonuclease activity
ID12_10070	COG4717	serine-type aminopeptidase activity
ID12_10075	COG3481	metal-dependent phosphohydrolase, HD sub domain
ID12_10085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ID12_10110	COG1846	Transcriptional regulator
ID12_10115	COG4980	gas vesicle protein
ID12_10130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ID12_10135	COG0537	adenosine 5'-monophosphoramidase activity
ID12_10145	COG1131	(ABC) transporter
ID12_10150	COG4473	ABC transporter
ID12_10160	COG1473	amidohydrolase
ID12_10170	COG2329	Antibiotic biosynthesis monooxygenase
ID12_10175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_10180	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ID12_10195	COG1309	transcriptional regulator
ID12_10200	COG1511	domain protein
ID12_10205	COG1363	Peptidase, m42
ID12_10210	COG1301	dicarboxylic acid transport
ID12_10220	COG1234	tRNA 3'-trailer cleavage
ID12_10225	COG0095	Lipoate-protein ligase
ID12_10230	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_10240	COG0501	Belongs to the peptidase M48B family
ID12_10245	COG1404	Belongs to the peptidase S8 family
ID12_10250	COG0406	alpha-ribazole phosphatase activity
ID12_10255	COG0840	transmembrane signaling receptor activity
ID12_10260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ID12_10260	COG0723	plastoquinol--plastocyanin reductase activity
ID12_10265	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_10275	COG4903	ComK protein
ID12_10290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_10295	COG2814	Major facilitator Superfamily
ID12_10300	COG2732	(Barnase) inhibitor
ID12_10305	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ID12_10310	COG4605	iron ion homeostasis
ID12_10315	COG4604	ABC transporter, ATP-binding protein
ID12_10320	COG4607	ABC-type enterochelin transport system periplasmic component
ID12_10325	COG1316	TRANSCRIPTIONal
ID12_10340	COG0398	Pfam SNARE associated Golgi protein
ID12_10345	COG0681	Belongs to the peptidase S26 family
ID12_10350	COG3180	Ammonia monooxygenase
ID12_10365	COG2259	Doxx family
ID12_10370	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ID12_10375	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ID12_10380	COG1074	ATP-dependent DNA helicase activity
ID12_10385	COG0420	3'-5' exonuclease activity
ID12_10390	COG0419	ATPase involved in DNA repair
ID12_10395	COG1403	HNH endonuclease
ID12_10435	COG5337	Spore coat protein CotH
ID12_10450	COG0179	Fumarylacetoacetate (FAA) hydrolase
ID12_10465	COG0367	asparagine synthase
ID12_10480	COG1562	ergosterol biosynthetic process
ID12_10485	COG0534	Mate efflux family protein
ID12_10490	COG2207	Transcriptional regulator
ID12_10490	COG1917	Cupin 2, conserved barrel domain protein
ID12_10515	COG0076	glutamate decarboxylase activity
ID12_10550	COG0646	methionine synthase
ID12_10550	COG1410	methionine synthase
ID12_10555	COG0646	methionine synthase
ID12_10555	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ID12_10560	COG1666	GTP binding
ID12_10565	COG2996	Protein conserved in bacteria
ID12_10575	COG0840	transmembrane signaling receptor activity
ID12_10580	COG1307	EDD domain protein, DegV family
ID12_10585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_10605	COG0561	phosphatase activity
ID12_10610	COG1073	alpha beta
ID12_10615	COG2151	metal-sulfur cluster biosynthetic enzyme
ID12_10620	COG0277	FAD linked oxidase domain protein
ID12_10625	COG2271	Major facilitator Superfamily
ID12_10630	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ID12_10640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ID12_10645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ID12_10650	COG0505	Belongs to the CarA family
ID12_10655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID12_10660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ID12_10670	COG2814	Major facilitator Superfamily
ID12_10685	COG2267	carboxylic ester hydrolase activity
ID12_10695	COG1744	ABC transporter substrate-binding protein PnrA-like
ID12_10710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID12_10715	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ID12_10720	COG5504	Zn-dependent protease
ID12_10725	COG0444	Belongs to the ABC transporter superfamily
ID12_10730	COG4608	Belongs to the ABC transporter superfamily
ID12_10740	COG0601	transmembrane transport
ID12_10745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_10755	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ID12_10760	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ID12_10790	COG0180	Tryptophanyl-tRNA synthetase
ID12_10795	COG4166	transmembrane transport
ID12_10800	COG0601	transmembrane transport
ID12_10805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_10810	COG0444	Belongs to the ABC transporter superfamily
ID12_10815	COG4608	Belongs to the ABC transporter superfamily
ID12_10825	COG0456	acetyltransferase
ID12_10830	COG1393	Belongs to the ArsC family
ID12_10835	COG0861	Integral membrane protein TerC family
ID12_10840	COG4862	establishment of competence for transformation
ID12_10845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_10855	COG1164	Oligoendopeptidase f
ID12_10870	COG2346	COG2346, Truncated hemoglobins
ID12_10875	COG0741	lytic transglycosylase activity
ID12_10880	COG4116	CYTH
ID12_10890	COG2357	RelA SpoT domain protein
ID12_10895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ID12_10900	COG0564	pseudouridine synthase activity
ID12_10905	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ID12_10910	COG0475	glutathione-regulated potassium exporter activity
ID12_10910	COG0569	domain protein
ID12_10915	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ID12_10920	COG0352	thiamine-phosphate diphosphorylase activity
ID12_10930	COG2104	thiamine diphosphate biosynthetic process
ID12_10935	COG2022	thiamine diphosphate biosynthetic process
ID12_10940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID12_10945	COG0351	phosphomethylpyrimidine kinase
ID12_10950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ID12_11010	COG0210	DNA helicase
ID12_11020	COG2153	protein acetylation
ID12_11025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ID12_11030	COG2382	esterase
ID12_11035	COG0626	cystathionine gamma-synthase activity
ID12_11040	COG0626	cystathionine gamma-synthase activity
ID12_11050	COG0825	malonyl-CoA metabolic process
ID12_11065	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_11090	COG0300	oxidoreductase activity
ID12_11105	COG3173	Aminoglycoside phosphotransferase
ID12_11110	COG0583	DNA-binding transcription factor activity
ID12_11125	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_11130	COG0583	DNA-binding transcription factor activity
ID12_11135	COG2807	transmembrane transport
ID12_11160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ID12_11180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_11185	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ID12_11210	COG4195	phage-related replication protein
ID12_11215	COG2856	Zn peptidase
ID12_11225	COG5632	N-Acetylmuramoyl-L-alanine amidase
ID12_11225	COG3409	Peptidoglycan-binding domain 1 protein
ID12_11245	COG0306	phosphate transporter
ID12_11250	COG1392	Phosphate transport regulator
ID12_11260	COG0405	Gamma-glutamyltransferase
ID12_11265	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
ID12_11275	COG4208	sulfate ABC transporter
ID12_11290	COG3775	system Galactitol-specific IIC component
ID12_11305	COG1063	alcohol dehydrogenase
ID12_11310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID12_11315	COG0022	dehydrogenase e1 component
ID12_11315	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_11320	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_11325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID12_11330	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_11335	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_11340	COG2390	Transcriptional regulator
ID12_11350	COG0531	amino acid
ID12_11355	COG0346	lactoylglutathione lyase activity
ID12_11360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ID12_11365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_11370	COG2362	D-Aminopeptidase
ID12_11375	COG0601	transmembrane transport
ID12_11380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ID12_11385	COG0444	Belongs to the ABC transporter superfamily
ID12_11390	COG4166	transmembrane transport
ID12_11400	COG1619	proteins homologs of microcin C7 resistance protein MccF
ID12_11405	COG4948	Mandelate Racemase Muconate Lactonizing
ID12_11410	COG0791	NLP P60 protein
ID12_11415	COG4608	Belongs to the ABC transporter superfamily
ID12_11420	COG1834	amidinotransferase
ID12_11425	COG1607	acyl-coa hydrolase
ID12_11430	COG1695	Transcriptional regulator
ID12_11445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_11455	COG2076	Multidrug Resistance protein
ID12_11460	COG2076	Multidrug Resistance protein
ID12_11470	COG0788	formyltetrahydrofolate deformylase activity
ID12_11475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ID12_11480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ID12_11485	COG0457	Tetratricopeptide repeat
ID12_11495	COG1764	response to oxidative stress
ID12_11500	COG1846	Transcriptional regulator
ID12_11505	COG1764	response to oxidative stress
ID12_11510	COG0590	tRNA wobble adenosine to inosine editing
ID12_11515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ID12_11520	COG1404	Belongs to the peptidase S8 family
ID12_11535	COG0745	RESPONSE REGULATOR receiver
ID12_11540	COG5002	protein histidine kinase activity
ID12_11540	COG3850	Histidine kinase
ID12_11545	COG3212	peptidase
ID12_11550	COG3212	peptidase
ID12_11570	COG2239	Acts as a magnesium transporter
ID12_11580	COG0583	DNA-binding transcription factor activity
ID12_11590	COG0789	Transcriptional regulator
ID12_11605	COG1846	Transcriptional regulator
ID12_11610	COG3300	MHYT domain
ID12_11610	COG5001	Diguanylate cyclase
ID12_11615	COG0586	Pfam SNARE associated Golgi protein
ID12_11620	COG0861	Integral membrane protein TerC family
ID12_11625	COG1191	sigma factor activity
ID12_11645	COG0501	Belongs to the peptidase M48B family
ID12_11650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ID12_11655	COG2323	membrane
ID12_11670	COG3594	Acyltransferase
ID12_11675	COG5002	protein histidine kinase activity
ID12_11680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ID12_11690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ID12_11695	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ID12_11700	COG0436	Aminotransferase
ID12_11705	COG1850	ribulose-bisphosphate carboxylase activity
ID12_11710	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ID12_11715	COG0235	Class ii aldolase
ID12_11720	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ID12_11730	COG3852	Histidine kinase
ID12_11735	COG1846	Transcriptional regulator
ID12_11740	COG1360	Flagellar Motor Protein
ID12_11745	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ID12_11755	COG0542	response to heat
ID12_11760	COG3949	Membrane
ID12_11770	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ID12_11775	COG0720	synthase
ID12_11780	COG0602	queuosine metabolic process
ID12_11785	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ID12_11800	COG4873	Protein conserved in bacteria
ID12_11810	COG3773	Cell wall hydrolase
ID12_11815	COG2244	polysaccharide biosynthetic process
ID12_11820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_11825	COG2217	Heavy metal translocating P-type atpase
ID12_11830	COG0006	proline dipeptidase activity
ID12_11840	COG1609	Transcriptional regulator
ID12_11845	COG3711	transcriptional antiterminator
ID12_11850	COG1263	PTS System
ID12_11850	COG2190	(PTS) system
ID12_11850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_11855	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_11860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ID12_11870	COG1533	DNA photolyase activity
ID12_11875	COG0840	transmembrane signaling receptor activity
ID12_11885	COG2084	Dehydrogenase
ID12_11890	COG2340	Cysteine-rich secretory protein family
ID12_11895	COG0768	penicillin binding
ID12_11900	COG4191	Histidine kinase
ID12_11905	COG0436	Aminotransferase
ID12_11910	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ID12_11920	COG1714	RDD family
ID12_11930	COG0835	chemotaxis
ID12_11930	COG0784	Response regulator, receiver
ID12_11955	COG2814	Major facilitator Superfamily
ID12_11960	COG1376	ErfK ybiS ycfS ynhG family protein
ID12_11965	COG1408	metallophosphoesterase
ID12_11970	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_11975	COG2200	EAL domain
ID12_11980	COG3546	catalase activity
ID12_11985	COG4703	Protein of unknown function (DUF1797)
ID12_11990	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ID12_12000	COG0517	IMP dehydrogenase activity
ID12_12005	COG0583	DNA-binding transcription factor activity
ID12_12015	COG0716	FMN binding
ID12_12025	COG0716	FMN binding
ID12_12030	COG2171	N-acyltransferase activity
ID12_12035	COG1473	amidohydrolase
ID12_12045	COG0668	transmembrane transport
ID12_12050	COG0450	alkyl hydroperoxide reductase
ID12_12055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_12070	COG0746	molybdenum cofactor guanylyltransferase activity
ID12_12075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ID12_12080	COG0303	'Molybdopterin
ID12_12085	COG1763	Mo-molybdopterin cofactor biosynthetic process
ID12_12090	COG0314	molybdopterin synthase activity
ID12_12095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ID12_12110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ID12_12115	COG1136	(ABC) transporter
ID12_12120	COG0577	efflux transmembrane transporter activity
ID12_12125	COG1349	DNA-binding transcription factor activity
ID12_12130	COG1105	Belongs to the carbohydrate kinase PfkB family
ID12_12135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_12135	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_12135	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_12140	COG0681	Belongs to the peptidase S26 family
ID12_12150	COG0488	(ABC) transporter
ID12_12165	COG2309	aminopeptidase activity
ID12_12175	COG1077	Cell shape determining protein MreB Mrl
ID12_12180	COG2002	toxin-antitoxin pair type II binding
ID12_12185	COG3852	Histidine kinase
ID12_12190	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ID12_12190	COG2105	PFAM AIG2 family protein
ID12_12195	COG0569	domain protein
ID12_12200	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ID12_12205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ID12_12215	COG0561	phosphatase activity
ID12_12220	COG0242	peptide deformylase activity
ID12_12235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID12_12240	COG0022	dehydrogenase e1 component
ID12_12245	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_12250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID12_12255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_12265	COG1982	Orn Lys Arg decarboxylase major
ID12_12270	COG4476	Belongs to the UPF0223 family
ID12_12275	COG4493	Belongs to the UPF0637 family
ID12_12285	COG0483	inositol monophosphate 1-phosphatase activity
ID12_12300	COG1595	DNA-templated transcription, initiation
ID12_12330	COG4896	Protein conserved in bacteria
ID12_12340	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ID12_12345	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ID12_12350	COG2066	Belongs to the glutaminase family
ID12_12355	COG4838	Belongs to the UPF0358 family
ID12_12360	COG0772	Belongs to the SEDS family
ID12_12365	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ID12_12375	COG1612	heme a metabolic process
ID12_12380	COG0109	protoheme IX farnesyltransferase activity
ID12_12385	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ID12_12385	COG2010	Cytochrome c
ID12_12390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ID12_12395	COG1845	cytochrome c oxidase, subunit III
ID12_12400	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ID12_12405	COG3336	cytochrome c oxidase
ID12_12415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ID12_12420	COG2340	Cysteine-rich secretory protein family
ID12_12440	COG3679	Belongs to the UPF0342 family
ID12_12445	COG4471	UPF0298 protein
ID12_12450	COG0742	ribosomal rna small subunit methyltransferase
ID12_12455	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ID12_12460	COG3314	Sporulation integral membrane protein YlbJ
ID12_12465	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID12_12470	COG3480	Lon protease (S16) C-terminal proteolytic domain
ID12_12480	COG1399	metal-binding, possibly nucleic acid-binding protein
ID12_12485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ID12_12495	COG0454	-acetyltransferase
ID12_12500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ID12_12505	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ID12_12510	COG2001	Belongs to the MraZ family
ID12_12515	COG0275	rRNA processing
ID12_12520	COG4839	cell division protein FtsL
ID12_12530	COG0768	penicillin binding
ID12_12535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ID12_12545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ID12_12550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ID12_12555	COG0772	Belongs to the SEDS family
ID12_12560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ID12_12565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ID12_12570	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ID12_12575	COG3879	Bacterial protein of unknown function (DUF881)
ID12_12580	COG3879	Bacterial protein of unknown function (DUF881)
ID12_12585	COG3856	small basic protein
ID12_12590	COG0849	cell division
ID12_12595	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ID12_12600	COG4412	M6 family metalloprotease domain protein
ID12_12600	COG1404	Belongs to the peptidase S8 family
ID12_12615	COG1191	sigma factor activity
ID12_12620	COG1191	sigma factor activity
ID12_12625	COG2390	Transcriptional regulator
ID12_12640	COG3730	PTS system glucitol sorbitol-specific
ID12_12645	COG3732	PTS system glucitol sorbitol-specific
ID12_12655	COG1119	ATPase activity
ID12_12660	COG1873	PFAM PRC-barrel domain
ID12_12670	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ID12_12675	COG1799	cell septum assembly
ID12_12680	COG0762	integral membrane protein
ID12_12685	COG2302	S4 RNA-binding domain
ID12_12690	COG3599	regulation of cell shape
ID12_12695	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ID12_12700	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ID12_12705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ID12_12710	COG0564	pseudouridine synthase activity
ID12_12715	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ID12_12720	COG2233	PERMEase
ID12_12725	COG0540	Belongs to the ATCase OTCase family
ID12_12730	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ID12_12735	COG0505	Belongs to the CarA family
ID12_12740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ID12_12745	COG0543	2 iron, 2 sulfur cluster binding
ID12_12750	COG0167	dihydroorotate dehydrogenase activity
ID12_12755	COG0284	orotidine-5'-phosphate decarboxylase activity
ID12_12760	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ID12_12770	COG0175	sulfate reduction
ID12_12775	COG0306	phosphate transporter
ID12_12780	COG2046	Belongs to the sulfate adenylyltransferase family
ID12_12785	COG0529	Catalyzes the synthesis of activated sulfate
ID12_12790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ID12_12795	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ID12_12800	COG1648	precorrin-2 dehydrogenase activity
ID12_12810	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ID12_12815	COG1561	YicC-like family, N-terminal region
ID12_12820	COG2052	Domain of unknown function (DUF370)
ID12_12825	COG0194	GDP metabolic process
ID12_12830	COG1758	RNA polymerase activity
ID12_12835	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ID12_12840	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ID12_12845	COG0242	peptide deformylase activity
ID12_12850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ID12_12855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID12_12855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ID12_12860	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ID12_12865	COG0631	protein serine/threonine phosphatase activity
ID12_12870	COG0515	serine threonine protein kinase
ID12_12870	COG2815	serine threonine protein kinase
ID12_12875	COG1162	GTPase activity
ID12_12880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ID12_12885	COG1564	THIamine pyrophosphokinase
ID12_12895	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ID12_12900	COG1302	Protein conserved in bacteria
ID12_12905	COG1461	Dihydroxyacetone kinase
ID12_12910	COG1760	l-serine dehydratase
ID12_12915	COG1760	l-serine dehydratase
ID12_12920	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ID12_12925	COG1349	DNA-binding transcription factor activity
ID12_12930	COG0416	fatty acid biosynthetic process
ID12_12935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ID12_12940	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_12945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID12_12955	COG1196	nuclear chromosome segregation
ID12_12960	COG0552	protein localization to endoplasmic reticulum
ID12_12965	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ID12_12970	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ID12_12975	COG0228	four-way junction DNA binding
ID12_12980	COG1837	Belongs to the UPF0109 family
ID12_12990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ID12_12995	COG0336	Belongs to the RNA methyltransferase TrmD family
ID12_13000	COG0335	large ribosomal subunit rRNA binding
ID12_13005	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ID12_13010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ID12_13020	COG2257	FlhB HrpN YscU SpaS Family
ID12_13025	COG0045	succinate-CoA ligase (ADP-forming) activity
ID12_13030	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ID12_13035	COG0758	DNA mediated transformation
ID12_13040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ID12_13045	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ID12_13050	COG4974	Belongs to the 'phage' integrase family
ID12_13055	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ID12_13060	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ID12_13065	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ID12_13070	COG1815	bacterial-type flagellum-dependent cell motility
ID12_13075	COG1558	bacterial-type flagellum-dependent cell motility
ID12_13080	COG1677	Flagellar hook-basal body complex protein FliE
ID12_13085	COG1766	The M ring may be actively involved in energy transduction
ID12_13090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ID12_13095	COG1317	bacterial-type flagellum organization
ID12_13100	COG1157	protein secretion by the type III secretion system
ID12_13105	COG2882	bacterial-type flagellum organization
ID12_13110	COG3334	PFAM MgtE intracellular
ID12_13115	COG3144	bacterial-type flagellum assembly
ID12_13120	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ID12_13125	COG4786	Flagellar basal body rod
ID12_13130	COG1582	Flagellar protein (FlbD)
ID12_13135	COG1580	Controls the rotational direction of flagella during chemotaxis
ID12_13140	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ID12_13145	COG1776	CheC inhibitor of MCP methylation
ID12_13145	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ID12_13150	COG2201	protein-glutamate methylesterase activity
ID12_13155	COG3190	flagellar
ID12_13160	COG1338	Plays a role in the flagellum-specific transport system
ID12_13165	COG1987	bacterial-type flagellum assembly
ID12_13170	COG1684	flagellar biosynthetic protein fliR
ID12_13175	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ID12_13180	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ID12_13185	COG1419	protein localization to endoplasmic reticulum
ID12_13190	COG0455	bacterial-type flagellum organization
ID12_13195	COG2201	protein-glutamate methylesterase activity
ID12_13200	COG2198	Histidine kinase
ID12_13200	COG0643	Histidine kinase
ID12_13205	COG0835	chemotaxis
ID12_13210	COG1776	CheC inhibitor of MCP methylation
ID12_13220	COG1191	sigma factor activity
ID12_13235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ID12_13240	COG0528	UMP kinase activity
ID12_13245	COG0233	cytoplasmic translational termination
ID12_13250	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ID12_13255	COG4589	Belongs to the CDS family
ID12_13260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ID12_13265	COG0750	zinc metalloprotease
ID12_13270	COG0442	prolyl-tRNA aminoacylation
ID12_13275	COG2176	DNA-directed DNA polymerase activity
ID12_13300	COG0779	Required for maturation of 30S ribosomal subunits
ID12_13305	COG0195	Participates in both transcription termination and antitermination
ID12_13310	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ID12_13315	COG1358	cellular component organization or biogenesis
ID12_13320	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ID12_13325	COG1550	Protein conserved in bacteria
ID12_13330	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ID12_13335	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ID12_13340	COG0196	riboflavin kinase activity
ID12_13345	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ID12_13350	COG1185	polyribonucleotide nucleotidyltransferase activity
ID12_13355	COG0726	polysaccharide deacetylase
ID12_13360	COG0612	Peptidase, M16
ID12_13370	COG1873	PFAM PRC-barrel domain
ID12_13375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ID12_13380	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ID12_13385	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ID12_13390	COG0527	aspartate kinase activity
ID12_13400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ID12_13405	COG0740	serine-type endopeptidase activity
ID12_13415	COG4980	gas vesicle protein
ID12_13415	COG1674	ftsk spoiiie
ID12_13420	COG2188	Transcriptional regulator
ID12_13425	COG2814	Major facilitator Superfamily
ID12_13430	COG1033	growth of symbiont in host cell
ID12_13430	COG2409	Drug exporters of the RND superfamily
ID12_13435	COG0612	Peptidase, M16
ID12_13440	COG0612	Peptidase, M16
ID12_13450	COG1033	growth of symbiont in host cell
ID12_13450	COG2409	Drug exporters of the RND superfamily
ID12_13455	COG0300	oxidoreductase activity
ID12_13470	COG1426	Protein conserved in bacteria
ID12_13475	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ID12_13480	COG1058	Belongs to the CinA family
ID12_13480	COG1546	Belongs to the CinA family
ID12_13485	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ID12_13490	COG1418	mRNA catabolic process
ID12_13495	COG1692	metallophosphoesterase
ID12_13500	COG2359	stage V sporulation protein S
ID12_13505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ID12_13510	COG1063	alcohol dehydrogenase
ID12_13515	COG0156	8-amino-7-oxononanoate synthase activity
ID12_13525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID12_13530	COG4550	Control of competence regulator ComK, YlbF/YmcA
ID12_13540	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ID12_13545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ID12_13570	COG1329	Transcriptional regulator
ID12_13575	COG4195	phage-related replication protein
ID12_13580	COG0457	Tetratricopeptide repeat
ID12_13585	COG1404	Belongs to the peptidase S8 family
ID12_13590	COG4195	phage-related replication protein
ID12_13595	COG1764	response to oxidative stress
ID12_13625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ID12_13630	COG1923	regulation of RNA biosynthetic process
ID12_13645	COG1780	Probably involved in ribonucleotide reductase function
ID12_13650	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID12_13655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ID12_13660	COG4112	unkown
ID12_13670	COG0464	growth
ID12_13680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ID12_13685	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ID12_13690	COG0789	Transcriptional regulator
ID12_13695	COG0174	glutamine synthetase
ID12_13740	COG0457	Tetratricopeptide repeat
ID12_13765	COG0604	alcohol dehydrogenase
ID12_13775	COG5444	nuclease activity
ID12_13805	COG5646	InterPro IPR014922
ID12_13825	COG0457	Tetratricopeptide repeat
ID12_13840	COG3619	membrane
ID12_13845	COG1793	dna ligase
ID12_13845	COG3285	dna ligase
ID12_13850	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ID12_13855	COG4876	unkown
ID12_13865	COG1959	2 iron, 2 sulfur cluster binding
ID12_13870	COG0702	epimerase
ID12_13880	COG0247	lactate metabolic process
ID12_13885	COG1139	Iron-sulfur cluster binding protein
ID12_13890	COG1556	Lactate utilization protein
ID12_13910	COG2323	membrane
ID12_13915	COG1309	transcriptional regulator
ID12_13920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ID12_13920	COG2124	cytochrome p450
ID12_13925	COG3591	Belongs to the peptidase S1B family
ID12_13930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ID12_13935	COG3209	COG3209 Rhs family protein
ID12_13940	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_13955	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ID12_13960	COG1388	LysM domain
ID12_13965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ID12_13970	COG4224	UPF0291 protein
ID12_13975	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ID12_13985	COG3763	UPF0154 protein
ID12_13995	COG0785	Cytochrome C biogenesis protein
ID12_14000	COG4846	Membrane protein involved in cytochrome C biogenesis
ID12_14010	COG0071	Belongs to the small heat shock protein (HSP20) family
ID12_14025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ID12_14030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_14050	COG0824	Thioesterase
ID12_14060	COG4841	protein insertion into membrane
ID12_14065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ID12_14070	COG1832	CoA-binding protein
ID12_14075	COG0187	DNA topoisomerase II activity
ID12_14080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ID12_14095	COG0738	Major facilitator superfamily
ID12_14100	COG0473	3-isopropylmalate dehydrogenase activity
ID12_14105	COG0110	maltose O-acetyltransferase activity
ID12_14110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ID12_14115	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ID12_14120	COG0640	Transcriptional regulator
ID12_14135	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ID12_14140	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ID12_14150	COG1309	transcriptional regulator
ID12_14155	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID12_14160	COG1733	regulation of RNA biosynthetic process
ID12_14170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_14175	COG0251	oxidation-reduction process
ID12_14210	COG0657	acetylesterase activity
ID12_14215	COG0789	Transcriptional regulator
ID12_14220	COG2723	6-phospho-beta-galactosidase activity
ID12_14225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ID12_14225	COG1263	PTS System
ID12_14225	COG2190	(PTS) system
ID12_14240	COG2205	protein histidine kinase activity
ID12_14245	COG0745	RESPONSE REGULATOR receiver
ID12_14255	COG3507	Belongs to the glycosyl hydrolase 43 family
ID12_14260	COG1012	belongs to the aldehyde dehydrogenase family
ID12_14265	COG1486	melibiose metabolic process
ID12_14295	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ID12_14310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_14320	COG0456	acetyltransferase
ID12_14325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_14355	COG1846	Transcriptional regulator
ID12_14360	COG2814	Major facilitator Superfamily
ID12_14370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_14370	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_14370	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_14375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ID12_14375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_14375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ID12_14380	COG1105	Belongs to the carbohydrate kinase PfkB family
ID12_14390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ID12_14425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ID12_14440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ID12_14445	COG1024	Enoyl-CoA hydratase
ID12_14455	COG0511	ligase activity, forming carbon-carbon bonds
ID12_14460	COG0439	Biotin carboxylase
ID12_14465	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_14470	COG1960	acyl-CoA dehydrogenase activity
ID12_14475	COG1649	PFAM Uncharacterised BCR, COG1649
ID12_14485	COG1349	DNA-binding transcription factor activity
ID12_14490	COG1942	4-Oxalocrotonate Tautomerase
ID12_14500	COG3835	regulator
ID12_14505	COG0277	FAD linked oxidase domain protein
ID12_14510	COG0247	lactate metabolic process
ID12_14530	COG0166	Belongs to the GPI family
ID12_14535	COG2246	polysaccharide biosynthetic process
ID12_14540	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ID12_14545	COG0586	Pfam SNARE associated Golgi protein
ID12_14550	COG1587	Uroporphyrinogen-III synthase
ID12_14560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ID12_14580	COG0534	Mate efflux family protein
ID12_14585	COG2027	D-alanyl-D-alanine carboxypeptidase
ID12_14590	COG4677	pectinesterase activity
ID12_14595	COG2323	membrane
ID12_14600	COG2146	nitrite reductase [NAD(P)H] activity
ID12_14605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID12_14610	COG0243	molybdopterin cofactor binding
ID12_14615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ID12_14620	COG2223	nitrite transmembrane transporter activity
ID12_14625	COG0493	'glutamate synthase
ID12_14630	COG0067	glutamate synthase
ID12_14630	COG0069	glutamate synthase activity
ID12_14630	COG0070	glutamate synthase
ID12_14635	COG0583	DNA-binding transcription factor activity
ID12_14645	COG1132	(ABC) transporter
ID12_14650	COG0789	Transcriptional regulator
ID12_14650	COG4978	Transcriptional regulator
ID12_14655	COG0454	-acetyltransferase
ID12_14660	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ID12_14665	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ID12_14670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_14680	COG0243	molybdopterin cofactor binding
ID12_14690	COG1070	Carbohydrate kinase
ID12_14695	COG2115	Belongs to the xylose isomerase family
ID12_14700	COG1940	carbohydrate kinase activity
ID12_14710	COG2211	Major facilitator Superfamily
ID12_14715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_14720	COG1994	Peptidase M50
ID12_14740	COG1309	transcriptional regulator
ID12_14745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_14750	COG3708	Transcriptional regulator
ID12_14755	COG2378	regulation of single-species biofilm formation
ID12_14770	COG0640	Transcriptional regulator
ID12_14775	COG0531	amino acid
ID12_14780	COG0741	lytic transglycosylase activity
ID12_14785	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ID12_14790	COG2079	MmgE PrpD family protein
ID12_14795	COG0372	Belongs to the citrate synthase family
ID12_14800	COG2322	membrane
ID12_14810	COG1388	LysM domain
ID12_14810	COG3584	3D domain protein
ID12_14815	COG0514	ATP-dependent DNA helicase (RecQ)
ID12_14820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ID12_14845	COG1012	belongs to the aldehyde dehydrogenase family
ID12_14850	COG1657	PFAM Prenyltransferase squalene oxidase
ID12_14855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ID12_14860	COG0385	Bile acid
ID12_14865	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_14870	COG0567	Dehydrogenase, E1 component
ID12_14875	COG4548	von Willebrand factor, type A
ID12_14880	COG0714	Associated with various cellular activities
ID12_14885	COG2032	superoxide dismutase activity
ID12_14890	COG1388	LysM domain
ID12_14890	COG0791	NLP P60 protein
ID12_14895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ID12_14905	COG0534	Mate efflux family protein
ID12_14910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID12_14915	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID12_14925	COG2962	Rard protein
ID12_14940	COG1733	regulation of RNA biosynthetic process
ID12_14945	COG0778	Nitroreductase
ID12_14955	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ID12_14960	COG0793	Belongs to the peptidase S41A family
ID12_14960	COG3409	Peptidoglycan-binding domain 1 protein
ID12_14965	COG2226	methyltransferase
ID12_14975	COG1876	peptidase activity
ID12_14980	COG0813	purine-nucleoside phosphorylase activity
ID12_14990	COG0671	phosphoesterase, PA-phosphatase related
ID12_15010	COG4479	Belongs to the UPF0346 family
ID12_15020	COG1509	lysine 2,3-aminomutase activity
ID12_15025	COG3829	transcription factor binding
ID12_15030	COG0463	Glycosyl transferase, family 2
ID12_15045	COG4641	Protein conserved in bacteria
ID12_15055	COG1086	Polysaccharide biosynthesis protein
ID12_15060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID12_15065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ID12_15070	COG1846	Transcriptional regulator
ID12_15090	COG4698	Protein conserved in bacteria
ID12_15095	COG2755	lipolytic protein G-D-S-L family
ID12_15100	COG1999	signal sequence binding
ID12_15115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ID12_15120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ID12_15125	COG1272	protein, Hemolysin III
ID12_15130	COG0204	Acyl-transferase
ID12_15135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ID12_15140	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ID12_15145	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ID12_15160	COG2136	Putative SAM-dependent methyltransferase
ID12_15160	COG2521	methyltransferase
ID12_15170	COG0129	dihydroxy-acid dehydratase activity
ID12_15175	COG1413	lyase activity
ID12_15180	COG1418	mRNA catabolic process
ID12_15185	COG0386	Belongs to the glutathione peroxidase family
ID12_15190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
ID12_15195	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ID12_15200	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ID12_15210	COG1278	Cold shock
ID12_15225	COG0328	RNA-DNA hybrid ribonuclease activity
ID12_15230	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ID12_15235	COG0328	RNA-DNA hybrid ribonuclease activity
ID12_15245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID12_15260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ID12_15265	COG1755	Isoprenylcysteine carboxyl methyltransferase
ID12_15270	COG3424	synthase
ID12_15280	COG0726	polysaccharide deacetylase
ID12_15285	COG2233	PERMEase
ID12_15290	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID12_15295	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ID12_15300	COG1199	ATP-dependent helicase activity
ID12_15310	COG0116	Belongs to the methyltransferase superfamily
ID12_15315	COG3599	regulation of cell shape
ID12_15320	COG4474	Belongs to the UPF0398 family
ID12_15330	COG3359	exonuclease
ID12_15335	COG1111	helicase
ID12_15335	COG1205	dead DEAH box helicase
ID12_15340	COG1902	pentaerythritol trinitrate reductase activity
ID12_15345	COG2190	(PTS) system
ID12_15350	COG0071	Belongs to the small heat shock protein (HSP20) family
ID12_15380	COG3331	DNA recombination
ID12_15385	COG4499	WXG100 protein secretion system (Wss), protein YukC
ID12_15385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ID12_15395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ID12_15400	COG3935	DnaD domain protein
ID12_15405	COG0017	Asparaginyl-tRNA synthetase
ID12_15410	COG5353	protein conserved in bacteria
ID12_15420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ID12_15420	COG1199	ATP-dependent helicase activity
ID12_15425	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ID12_15430	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ID12_15435	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ID12_15445	COG0617	tRNA 3'-terminal CCA addition
ID12_15450	COG0438	transferase activity, transferring glycosyl groups
ID12_15455	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ID12_15460	COG1803	Methylglyoxal synthase
ID12_15465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ID12_15470	COG1694	Mazg nucleotide pyrophosphohydrolase
ID12_15475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_15485	COG4347	Protein of unknown function (DUF1405)
ID12_15490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ID12_15490	COG2010	Cytochrome c
ID12_15495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ID12_15500	COG0723	plastoquinol--plastocyanin reductase activity
ID12_15510	COG5582	Belongs to the UPF0302 family
ID12_15515	COG0457	Tetratricopeptide repeat
ID12_15520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ID12_15525	COG0287	Prephenate dehydrogenase
ID12_15530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ID12_15535	COG0159	tryptophan synthase activity
ID12_15540	COG0133	tryptophan synthase activity
ID12_15545	COG0135	phosphoribosylanthranilate isomerase activity
ID12_15550	COG0134	indole-3-glycerol-phosphate synthase activity
ID12_15555	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ID12_15565	COG4401	Chorismate mutase type I
ID12_15570	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ID12_15575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ID12_15580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ID12_15585	COG0105	UTP biosynthetic process
ID12_15590	COG0142	geranyltranstransferase activity
ID12_15595	COG2226	methyltransferase
ID12_15600	COG0142	geranyltranstransferase activity
ID12_15610	COG0302	gtp cyclohydrolase
ID12_15615	COG0776	regulation of translation
ID12_15620	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ID12_15635	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ID12_15640	COG1160	GTP binding
ID12_15665	COG1304	FMN binding
ID12_15670	COG0539	negative regulation of cytoplasmic translation
ID12_15675	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ID12_15685	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ID12_15690	COG2959	enzyme of heme biosynthesis
ID12_15695	COG3409	Peptidoglycan-binding domain 1 protein
ID12_15695	COG3773	Cell wall hydrolase
ID12_15700	COG2339	peptidase activity
ID12_15705	COG0492	ferredoxin-NADP+ reductase activity
ID12_15710	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID12_15715	COG4862	establishment of competence for transformation
ID12_15720	COG1408	metallophosphoesterase
ID12_15730	COG1388	LysM domain
ID12_15735	COG1266	CAAX protease self-immunity
ID12_15740	COG0514	ATP-dependent DNA helicase (RecQ)
ID12_15745	COG4955	Helix-turn-helix domain
ID12_15750	COG1141	Ferredoxin
ID12_15755	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ID12_15760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ID12_15775	COG1595	DNA-templated transcription, initiation
ID12_15780	COG5002	protein histidine kinase activity
ID12_15785	COG0745	RESPONSE REGULATOR receiver
ID12_15790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ID12_15795	COG1333	cytochrome c biogenesis protein
ID12_15800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_15805	COG1187	pseudouridine synthase activity
ID12_15810	COG0700	Nucleoside recognition
ID12_15815	COG2715	membrane protein required for spore maturation
ID12_15820	COG1686	Belongs to the peptidase S11 family
ID12_15830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ID12_15835	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ID12_15845	COG1547	Domain of unknown function (DUF309)
ID12_15850	COG0456	acetyltransferase
ID12_15855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ID12_15865	COG0307	riboflavin synthase, alpha
ID12_15885	COG2814	Major facilitator Superfamily
ID12_15890	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ID12_15895	COG4086	secreted protein
ID12_15900	COG0019	diaminopimelate decarboxylase activity
ID12_15905	COG0697	spore germination
ID12_15920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ID12_15940	COG1191	sigma factor activity
ID12_15945	COG2172	sigma factor antagonist activity
ID12_15955	COG1686	Belongs to the peptidase S11 family
ID12_15960	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ID12_15965	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ID12_15970	COG4974	Belongs to the 'phage' integrase family
ID12_15980	COG0735	belongs to the Fur family
ID12_15985	COG1300	Membrane
ID12_15990	COG1404	Belongs to the peptidase S8 family
ID12_16000	COG2153	protein acetylation
ID12_16005	COG1379	DNA repair
ID12_16010	COG0494	nUDIX hydrolase
ID12_16015	COG0667	Aldo Keto reductase
ID12_16025	COG1073	alpha beta
ID12_16030	COG0457	Tetratricopeptide repeat
ID12_16040	COG4918	Iron-sulphur cluster biosynthesis
ID12_16045	COG4305	rare lipoprotein A
ID12_16050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ID12_16050	COG0456	acetyltransferase
ID12_16055	COG0456	acetyltransferase
ID12_16065	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID12_16075	COG2211	Major facilitator Superfamily
ID12_16080	COG1072	(Pantothenic acid kinase))
ID12_16085	COG0446	pyridine nucleotide-disulphide oxidoreductase
ID12_16095	COG0300	oxidoreductase activity
ID12_16100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_16110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_16120	COG4187	Peptidase family M20/M25/M40
ID12_16125	COG1902	pentaerythritol trinitrate reductase activity
ID12_16130	COG0596	Alpha beta hydrolase
ID12_16135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ID12_16145	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ID12_16150	COG2188	Transcriptional regulator
ID12_16155	COG2723	6-phospho-beta-galactosidase activity
ID12_16160	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_16165	COG1447	Phosphotransferase system cellobiose-specific component IIA
ID12_16170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ID12_16180	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_16190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ID12_16195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ID12_16205	COG0706	membrane insertase activity
ID12_16210	COG0835	chemotaxis
ID12_16215	COG2195	Cleaves the N-terminal amino acid of tripeptides
ID12_16220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ID12_16225	COG0346	lactoylglutathione lyase activity
ID12_16235	COG1376	ErfK ybiS ycfS ynhG family protein
ID12_16240	COG4129	membrane
ID12_16245	COG1126	abc transporter atp-binding protein
ID12_16250	COG0765	amino acid transport
ID12_16255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_16265	COG1597	lipid kinase activity
ID12_16275	COG0508	dehydrogenase complex catalyzes the overall conversion of
ID12_16280	COG0022	dehydrogenase e1 component
ID12_16285	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ID12_16290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ID12_16295	COG3426	butyrate kinase activity
ID12_16300	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ID12_16305	COG0280	phosphate acetyltransferase
ID12_16315	COG3829	transcription factor binding
ID12_16315	COG3290	protein histidine kinase activity
ID12_16325	COG0584	glycerophosphoryl diester phosphodiesterase
ID12_16335	COG0457	Tetratricopeptide repeat
ID12_16340	COG0745	RESPONSE REGULATOR receiver
ID12_16345	COG0750	zinc metalloprotease
ID12_16350	COG0497	DNA recombination
ID12_16355	COG1438	arginine binding
ID12_16360	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ID12_16365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ID12_16370	COG0142	geranyltranstransferase activity
ID12_16375	COG1722	exodeoxyribonuclease VII activity
ID12_16380	COG1570	exodeoxyribonuclease VII activity
ID12_16385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ID12_16390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ID12_16395	COG1302	Protein conserved in bacteria
ID12_16400	COG0439	Biotin carboxylase
ID12_16405	COG0511	ligase activity, forming carbon-carbon bonds
ID12_16445	COG3854	ATPases associated with a variety of cellular activities
ID12_16455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ID12_16460	COG0006	proline dipeptidase activity
ID12_16465	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ID12_16475	COG3872	metal-dependent enzyme
ID12_16485	COG1752	Esterase of the alpha-beta hydrolase superfamily
ID12_16490	COG1321	iron dependent repressor
ID12_16495	COG0095	Lipoate-protein ligase
ID12_16500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_16505	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ID12_16510	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ID12_16515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ID12_16520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ID12_16545	COG0681	Belongs to the peptidase S26 family
ID12_16580	COG4970	Tfp pilus assembly protein FimT
ID12_16585	COG4537	Required for transformation and DNA binding
ID12_16590	COG1459	type II secretion system
ID12_16595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ID12_16600	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_16615	COG1393	Belongs to the ArsC family
ID12_16625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_16635	COG0011	TIGRFAM Protein of
ID12_16640	COG2814	Major facilitator Superfamily
ID12_16645	COG2866	Carboxypeptidase
ID12_16650	COG1368	sulfuric ester hydrolase activity
ID12_16655	COG1940	carbohydrate kinase activity
ID12_16660	COG4483	Protein conserved in bacteria
ID12_16665	COG0705	Rhomboid family
ID12_16665	COG0457	Tetratricopeptide repeat
ID12_16680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ID12_16685	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ID12_16700	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ID12_16705	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ID12_16710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ID12_16715	COG0581	inorganic phosphate transmembrane transporter activity
ID12_16720	COG0573	inorganic phosphate transmembrane transporter activity
ID12_16725	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ID12_16735	COG0477	Major facilitator Superfamily
ID12_16740	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ID12_16745	COG2839	Protein conserved in bacteria
ID12_16750	COG5521	maltodextrose utilization protein MalA
ID12_16755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ID12_16760	COG1388	LysM domain
ID12_16765	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ID12_16770	COG4709	membrane
ID12_16775	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ID12_16780	COG1940	carbohydrate kinase activity
ID12_16785	COG0735	belongs to the Fur family
ID12_16790	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ID12_16795	COG1121	(ABC) transporter
ID12_16800	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ID12_16815	COG0513	Belongs to the DEAD box helicase family
ID12_16825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ID12_16830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ID12_16835	COG2384	SAM-dependent methyltransferase
ID12_16840	COG2010	Cytochrome c
ID12_16845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ID12_16850	COG0358	DNA primase activity
ID12_16855	COG1671	Belongs to the UPF0178 family
ID12_16860	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ID12_16865	COG0517	IMP dehydrogenase activity
ID12_16870	COG0751	glycine-tRNA ligase activity
ID12_16875	COG0752	glycyl-tRNA synthetase alpha subunit
ID12_16880	COG1381	Involved in DNA repair and RecF pathway recombination
ID12_16890	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ID12_16895	COG0295	cytidine deaminase activity
ID12_16900	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ID12_16905	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ID12_16910	COG1480	7TM receptor with intracellular HD hydrolase
ID12_16915	COG1702	phosphate starvation-inducible protein PhoH
ID12_16920	COG0561	phosphatase activity
ID12_16935	COG4864	UPF0365 protein
ID12_16940	COG1030	water channel activity
ID12_16945	COG1610	YqeY-like protein
ID12_16950	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ID12_16955	COG1283	sodium-dependent phosphate transmembrane transporter activity
ID12_16960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ID12_16965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ID12_16970	COG2264	protein methyltransferase activity
ID12_16975	COG0484	heat shock protein binding
ID12_16980	COG0443	Heat shock 70 kDa protein
ID12_16985	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ID12_16990	COG1420	regulation of RNA biosynthetic process
ID12_16995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ID12_17000	COG0481	GTPase activity
ID12_17010	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_17015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ID12_17020	COG0268	Binds directly to 16S ribosomal RNA
ID12_17025	COG1466	dna polymerase III delta subunit
ID12_17035	COG2333	competence protein COMEC
ID12_17035	COG0658	competence protein
ID12_17040	COG2131	deaminase
ID12_17045	COG1596	polysaccharide export
ID12_17045	COG1555	photosystem II stabilization
ID12_17050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ID12_17055	COG2226	methyltransferase
ID12_17060	COG0799	negative regulation of ribosome biogenesis
ID12_17065	COG1713	HD superfamily hydrolase involved in NAD metabolism
ID12_17070	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ID12_17075	COG1534	Rna-binding protein
ID12_17080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ID12_17085	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ID12_17090	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ID12_17105	COG2755	lipolytic protein G-D-S-L family
ID12_17115	COG0457	Tetratricopeptide repeat
ID12_17145	COG0726	polysaccharide deacetylase
ID12_17180	COG1122	ATPase activity
ID12_17210	COG2160	L-arabinose isomerase activity
ID12_17225	COG1609	Transcriptional regulator
ID12_17235	COG1846	Transcriptional regulator
ID12_17245	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ID12_17250	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ID12_17255	COG1733	regulation of RNA biosynthetic process
ID12_17325	COG2602	Beta-lactamase
ID12_17330	COG1960	acyl-CoA dehydrogenase activity
ID12_17335	COG1126	abc transporter atp-binding protein
ID12_17340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_17345	COG0765	amino acid transport
ID12_17355	COG3546	catalase activity
ID12_17360	COG1063	alcohol dehydrogenase
ID12_17375	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_17385	COG1115	amino acid carrier protein
ID12_17390	COG0583	DNA-binding transcription factor activity
ID12_17395	COG0842	Transport permease protein
ID12_17400	COG0842	Transport permease protein
ID12_17400	COG1511	domain protein
ID12_17405	COG1131	(ABC) transporter
ID12_17410	COG1063	alcohol dehydrogenase
ID12_17415	COG2226	methyltransferase
ID12_17435	COG0626	cystathionine gamma-synthase activity
ID12_17440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_17445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ID12_17450	COG2226	methyltransferase
ID12_17465	COG0768	penicillin binding
ID12_17470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ID12_17475	COG0572	uridine kinase
ID12_17495	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ID12_17500	COG0183	Belongs to the thiolase family
ID12_17505	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_17510	COG1268	BioY protein
ID12_17515	COG3906	Belongs to the UPF0473 family
ID12_17520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ID12_17525	COG4472	Bacterial protein of unknown function (DUF965)
ID12_17530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ID12_17535	COG0628	permease
ID12_17540	COG1126	abc transporter atp-binding protein
ID12_17545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ID12_17550	COG0765	amino acid transport
ID12_17555	COG0765	amino acid transport
ID12_17570	COG3881	PFAM PRC-barrel domain
ID12_17575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ID12_17580	COG0457	Tetratricopeptide repeat
ID12_17585	COG0482	sulfurtransferase activity
ID12_17590	COG1104	cysteine desulfurase activity
ID12_17595	COG1959	2 iron, 2 sulfur cluster binding
ID12_17600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ID12_17605	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ID12_17615	COG0124	histidyl-tRNA synthetase
ID12_17625	COG0860	N-Acetylmuramoyl-L-alanine amidase
ID12_17625	COG4991	sh3 domain protein
ID12_17625	COG3103	Sh3 type 3 domain protein
ID12_17630	COG1490	D-aminoacyl-tRNA deacylase activity
ID12_17635	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ID12_17640	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ID12_17645	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ID12_17645	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ID12_17650	COG5416	Lipopolysaccharide assembly protein A domain
ID12_17655	COG0490	domain, Protein
ID12_17660	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ID12_17660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ID12_17670	COG2244	polysaccharide biosynthetic process
ID12_17675	COG2323	membrane
ID12_17685	COG1862	Preprotein translocase
ID12_17690	COG0343	queuine tRNA-ribosyltransferase activity
ID12_17695	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ID12_17705	COG2255	four-way junction helicase activity
ID12_17710	COG0632	four-way junction helicase activity
ID12_17720	COG2112	serine threonine protein kinase
ID12_17735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ID12_17750	COG1388	LysM domain
ID12_17755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ID12_17760	COG0157	Belongs to the NadC ModD family
ID12_17765	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ID12_17770	COG1104	cysteine desulfurase activity
ID12_17775	COG1827	regulation of RNA biosynthetic process
ID12_17780	COG0077	Prephenate dehydratase
ID12_17785	COG4492	Belongs to the UPF0735 family
ID12_17790	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ID12_17795	COG3290	protein histidine kinase activity
ID12_17800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ID12_17805	COG2868	ribosomal protein
ID12_17810	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ID12_17815	COG1994	Peptidase M50
ID12_17820	COG0739	heme binding
ID12_17825	COG2894	cell division
ID12_17830	COG0850	regulation of cytokinetic process
ID12_17835	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ID12_17840	COG1792	Involved in formation and maintenance of cell shape
ID12_17845	COG1077	Cell shape determining protein MreB Mrl
ID12_17850	COG2003	Belongs to the UPF0758 family
ID12_17855	COG0424	maF-like protein
ID12_17870	COG0285	dihydrofolate synthase activity
ID12_17875	COG0525	valine-tRNA ligase activity
ID12_17885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ID12_17890	COG1388	LysM domain
ID12_17895	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ID12_17900	COG0113	porphobilinogen synthase activity
ID12_17905	COG1587	Uroporphyrinogen-III synthase
ID12_17910	COG0181	hydroxymethylbilane synthase activity
ID12_17915	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ID12_17920	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ID12_17930	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ID12_17935	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ID12_17940	COG1067	ATP-dependent peptidase activity
ID12_17940	COG0470	DNA polymerase III
ID12_17945	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ID12_17950	COG0544	peptidyl-prolyl cis-trans isomerase activity
ID12_17955	COG1477	protein flavinylation
ID12_17955	COG0457	Tetratricopeptide repeat
ID12_17960	COG0066	3-isopropylmalate dehydratase activity
ID12_17965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ID12_17970	COG0473	3-isopropylmalate dehydrogenase activity
ID12_17975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ID12_17980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ID12_17985	COG0440	acetolactate synthase activity
ID12_17990	COG0028	Belongs to the TPP enzyme family
ID12_17995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ID12_18005	COG2706	6-phosphogluconolactonase activity
ID12_18010	COG3339	Conserved Protein
ID12_18015	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ID12_18020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ID12_18025	COG1696	Membrane protein involved in D-alanine export
ID12_18080	COG0622	Phosphoesterase
ID12_18085	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ID12_18090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ID12_18095	COG5401	PFAM Sporulation and spore germination
ID12_18100	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ID12_18105	COG1846	Transcriptional regulator
ID12_18110	COG2197	response regulator
ID12_18115	COG2851	Citrate transporter
ID12_18120	COG0583	DNA-binding transcription factor activity
ID12_18125	COG2828	Protein conserved in bacteria
ID12_18135	COG0824	Thioesterase
ID12_18140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ID12_18145	COG1053	succinate dehydrogenase
ID12_18150	COG2009	succinate dehydrogenase
ID12_18155	COG1719	4-vinyl reductase, 4VR
ID12_18160	COG0527	aspartate kinase activity
ID12_18165	COG0322	excinuclease ABC activity
ID12_18170	COG3118	belongs to the thioredoxin family
ID12_18175	COG3534	alpha-L-arabinofuranosidase
ID12_18180	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ID12_18185	COG2086	electron transfer activity
ID12_18190	COG1024	Enoyl-CoA hydratase
ID12_18195	COG1309	transcriptional regulator
ID12_18200	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_18210	COG3766	membrane
ID12_18215	COG1193	negative regulation of DNA recombination
ID12_18220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ID12_18220	COG1796	DNA polymerase
ID12_18225	COG1286	toxin biosynthetic process
ID12_18230	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ID12_18235	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ID12_18240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_18240	COG0072	phenylalanine-tRNA ligase activity
ID12_18245	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ID12_18250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ID12_18260	COG1966	Carbon starvation protein
ID12_18265	COG1363	Peptidase, m42
ID12_18275	COG3326	Membrane
ID12_18280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ID12_18285	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ID12_18290	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ID12_18315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ID12_18325	COG0398	Pfam SNARE associated Golgi protein
ID12_18330	COG1484	DNA-dependent DNA replication
ID12_18335	COG3611	Membrane attachment protein
ID12_18340	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ID12_18350	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ID12_18355	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ID12_18360	COG0237	dephospho-CoA kinase activity
ID12_18365	COG1971	Probably functions as a manganese efflux pump
ID12_18370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ID12_18375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID12_18375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ID12_18380	COG5002	protein histidine kinase activity
ID12_18385	COG0745	RESPONSE REGULATOR receiver
ID12_18390	COG0039	L-malate dehydrogenase activity
ID12_18395	COG0538	isocitrate dehydrogenase activity
ID12_18400	COG0372	Belongs to the citrate synthase family
ID12_18405	COG2707	UPF0756 membrane protein
ID12_18410	COG0628	permease
ID12_18415	COG3030	protein affecting phage T7 exclusion by the F plasmid
ID12_18425	COG0205	6-phosphofructokinase activity
ID12_18430	COG0825	malonyl-CoA metabolic process
ID12_18435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ID12_18440	COG0281	malic enzyme
ID12_18445	COG0587	DNA-directed DNA polymerase activity
ID12_18465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ID12_18480	COG4109	DRTGG domain
ID12_18485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ID12_18490	COG1028	Short-chain dehydrogenase reductase Sdr
ID12_18500	COG0165	Argininosuccinate lyase
ID12_18505	COG0137	argininosuccinate synthase activity
ID12_18510	COG0521	Mo-molybdopterin cofactor biosynthetic process
ID12_18515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ID12_18520	COG0827	DNA restriction-modification system
ID12_18525	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ID12_18530	COG3874	Sporulation protein YtfJ
ID12_18540	COG1714	RDD family
ID12_18545	COG0616	signal peptide processing
ID12_18550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ID12_18560	COG3239	Fatty acid desaturase
ID12_18570	COG4585	Histidine kinase
ID12_18575	COG2197	response regulator
ID12_18580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ID12_18585	COG0745	RESPONSE REGULATOR receiver
ID12_18590	COG2205	protein histidine kinase activity
ID12_18595	COG0772	Belongs to the SEDS family
ID12_18600	COG1695	Transcriptional regulator
ID12_18605	COG1136	(ABC) transporter
ID12_18610	COG0577	efflux transmembrane transporter activity
ID12_18615	COG0402	S-adenosylhomocysteine deaminase activity
ID12_18620	COG2249	NAD(P)H dehydrogenase (quinone) activity
ID12_18640	COG1279	arginine transmembrane transporter activity
ID12_18645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ID12_18655	COG0301	tRNA thio-modification
ID12_18660	COG1104	cysteine desulfurase activity
ID12_18665	COG1114	Component of the transport system for branched-chain amino acids
ID12_18670	COG1114	Component of the transport system for branched-chain amino acids
ID12_18675	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ID12_18680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ID12_18685	COG1309	transcriptional regulator
ID12_18690	COG1956	GAF domain-containing protein
ID12_18700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ID12_18710	COG1335	isochorismatase
ID12_18720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ID12_18725	COG2329	Antibiotic biosynthesis monooxygenase
ID12_18730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ID12_18735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ID12_18740	COG0454	-acetyltransferase
ID12_18745	COG0517	IMP dehydrogenase activity
ID12_18750	COG0123	including yeast histone deacetylase and acetoin utilization protein
ID12_18755	COG1609	Transcriptional regulator
ID12_18760	COG1605	Chorismate mutase
ID12_18760	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ID12_18765	COG3118	belongs to the thioredoxin family
ID12_18770	COG4980	gas vesicle protein
ID12_18775	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ID12_18780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ID12_18785	COG1674	ftsk spoiiie
ID12_18790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ID12_18795	COG4848	Belongs to the UPF0354 family
ID12_18800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ID12_18815	COG1363	Peptidase, m42
ID12_18820	COG5584	Small secreted protein
ID12_18825	COG0281	malic enzyme
ID12_18830	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ID12_18835	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ID12_18845	COG0510	thiamine kinase activity
ID12_18850	COG1597	lipid kinase activity
ID12_18860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ID12_18865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ID12_18870	COG3340	Belongs to the peptidase S51 family
ID12_18875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ID12_18880	COG2252	PERMEase
ID12_18885	COG1349	DNA-binding transcription factor activity
ID12_18890	COG1187	pseudouridine synthase activity
ID12_18895	COG2244	polysaccharide biosynthetic process
ID12_18900	COG2081	HI0933 family
ID12_18910	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ID12_18915	COG3196	Protein conserved in bacteria
ID12_18925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ID12_18930	COG5578	integral membrane protein
ID12_18935	COG0673	inositol 2-dehydrogenase activity
ID12_18940	COG1653	transport
ID12_18945	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ID12_18950	COG4209	transmembrane transport
ID12_18955	COG2207	Transcriptional regulator
ID12_18960	COG1733	regulation of RNA biosynthetic process
ID12_18965	COG2814	Major facilitator Superfamily
ID12_18970	COG0656	L-ascorbic acid biosynthetic process
ID12_18975	COG1653	transport
ID12_18980	COG0395	ABC-type sugar transport system, permease component
ID12_18990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ID12_18995	COG1073	alpha beta
ID12_19000	COG0495	leucyl-tRNA aminoacylation
ID12_19015	COG2202	Pas domain
ID12_19015	COG1366	Belongs to the anti-sigma-factor antagonist family
ID12_19020	COG2433	Pfam Transposase IS66
ID12_19025	COG0577	efflux transmembrane transporter activity
ID12_19030	COG1136	(ABC) transporter
ID12_19040	COG1131	(ABC) transporter
ID12_19045	COG1725	Transcriptional regulator
ID12_19060	COG1242	4 iron, 4 sulfur cluster binding
ID12_19065	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ID12_19070	COG4326	sporulation control protein
ID12_19080	COG2267	carboxylic ester hydrolase activity
ID12_19085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ID12_19090	COG0367	asparagine synthase
ID12_19095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ID12_19100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ID12_19110	COG1506	peptidase
ID12_19115	COG1233	COG1233 Phytoene dehydrogenase and related
ID12_19135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ID12_19140	COG1116	anion transmembrane transporter activity
ID12_19145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ID12_19150	COG0494	nUDIX hydrolase
ID12_19155	COG2310	stress, protein
ID12_19170	COG4824	toxin secretion phage lysis holin
ID12_19180	COG0783	Belongs to the Dps family
ID12_19195	COG1854	S-ribosylhomocysteine lyase activity
ID12_19200	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ID12_19205	COG0288	reversible hydration of carbon dioxide
ID12_19210	COG3443	Belongs to the bacterial solute-binding protein 9 family
ID12_19210	COG0803	Belongs to the bacterial solute-binding protein 9 family
ID12_19220	COG1271	oxidase subunit
ID12_19225	COG1294	oxidase, subunit
ID12_19240	COG4948	Mandelate Racemase Muconate Lactonizing
ID12_19245	COG0318	PFAM AMP-dependent synthetase and ligase
ID12_19250	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ID12_19255	COG0596	Alpha beta hydrolase
ID12_19260	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ID12_19265	COG1169	isochorismate synthase
ID12_19270	COG1575	Belongs to the MenA family. Type 1 subfamily
ID12_19275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ID12_19425	COG0457	Tetratricopeptide repeat