locus-tag	class	description
BW16_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BW16_00010	COG0592	DNA-directed DNA polymerase activity
BW16_00015	COG2501	S4 domain
BW16_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BW16_00030	COG0187	DNA topoisomerase II activity
BW16_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW16_00075	COG0517	IMP dehydrogenase activity
BW16_00075	COG0516	GMP reductase activity
BW16_00080	COG1686	Belongs to the peptidase S11 family
BW16_00085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_00090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
BW16_00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BW16_00100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BW16_00105	COG0840	transmembrane signaling receptor activity
BW16_00115	COG1428	Deoxynucleoside kinase
BW16_00120	COG1428	Deoxynucleoside kinase
BW16_00125	COG3858	chitin binding
BW16_00125	COG1388	LysM domain
BW16_00130	COG1335	isochorismatase
BW16_00135	COG0590	tRNA wobble adenosine to inosine editing
BW16_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BW16_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BW16_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BW16_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BW16_00200	COG3853	Toxic anion resistance protein (TelA)
BW16_00205	COG1982	Orn Lys Arg decarboxylase major
BW16_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BW16_00215	COG3870	Protein conserved in bacteria
BW16_00220	COG1728	Protein conserved in bacteria
BW16_00225	COG0470	DNA polymerase III
BW16_00230	COG1774	PSP1 C-terminal conserved region
BW16_00235	COG4467	Involved in initiation control of chromosome replication
BW16_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BW16_00245	COG2827	Endonuclease containing a URI domain
BW16_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BW16_00255	COG2002	toxin-antitoxin pair type II binding
BW16_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_00265	COG0084	hydrolase, TatD family'
BW16_00270	COG3584	3D domain protein
BW16_00270	COG3583	domain protein
BW16_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BW16_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BW16_00290	COG4466	Protein conserved in bacteria
BW16_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BW16_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW16_00310	COG0251	oxidation-reduction process
BW16_00315	COG2088	sporulation resulting in formation of a cellular spore
BW16_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW16_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BW16_00335	COG0193	aminoacyl-tRNA hydrolase activity
BW16_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BW16_00350	COG2002	toxin-antitoxin pair type II binding
BW16_00355	COG2244	polysaccharide biosynthetic process
BW16_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BW16_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BW16_00385	COG1098	S1 RNA binding domain
BW16_00400	COG2208	phosphoserine phosphatase activity
BW16_00405	COG2304	oxidoreductase activity
BW16_00410	COG0515	serine threonine protein kinase
BW16_00415	COG0037	tRNA processing
BW16_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW16_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BW16_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BW16_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BW16_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BW16_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
BW16_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BW16_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BW16_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BW16_00480	COG1396	sequence-specific DNA binding
BW16_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BW16_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BW16_00570	COG4463	regulation of RNA biosynthetic process
BW16_00575	COG3880	PFAM UvrB UvrC protein
BW16_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BW16_00585	COG0542	response to heat
BW16_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BW16_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BW16_00600	COG4956	integral membrane protein (PIN domain superfamily)
BW16_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BW16_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BW16_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW16_00620	COG1045	serine acetyltransferase
BW16_00625	COG0215	cysteine-tRNA ligase activity
BW16_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BW16_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW16_00640	COG3688	RNA-binding protein containing a PIN domain
BW16_00645	COG1595	DNA-templated transcription, initiation
BW16_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW16_00655	COG0250	Participates in transcription elongation, termination and antitermination
BW16_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BW16_00665	COG0081	regulation of translation
BW16_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BW16_00675	COG0222	ribosome binding
BW16_00680	COG2813	Specifically methylates the guanine in position
BW16_00685	COG0085	RNA polymerase activity
BW16_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BW16_00695	COG1358	cellular component organization or biogenesis
BW16_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BW16_00705	COG0049	tRNA binding
BW16_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BW16_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BW16_00720	COG0596	Alpha beta hydrolase
BW16_00725	COG0051	transcription antitermination factor activity, RNA binding
BW16_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BW16_00735	COG0088	Forms part of the polypeptide exit tunnel
BW16_00740	COG0089	rRNA binding
BW16_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BW16_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BW16_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BW16_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BW16_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BW16_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
BW16_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BW16_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BW16_00785	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BW16_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BW16_00795	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW16_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BW16_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BW16_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BW16_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BW16_00820	COG1841	ribosomal large subunit assembly
BW16_00825	COG0200	Binds to the 23S rRNA
BW16_00830	COG0201	protein transport
BW16_00835	COG0563	adenylate kinase activity
BW16_00840	COG0024	Methionine aminopeptidase
BW16_00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BW16_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BW16_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BW16_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BW16_00865	COG0202	RNA polymerase activity
BW16_00870	COG0203	ribosomal protein L17
BW16_00875	COG1122	ATPase activity
BW16_00880	COG1122	ATPase activity
BW16_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW16_00890	COG0101	tRNA pseudouridine synthase activity
BW16_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BW16_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BW16_00905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_00935	COG0489	protein tyrosine kinase activity
BW16_00945	COG2194	sulfuric ester hydrolase activity
BW16_00950	COG0726	polysaccharide deacetylase
BW16_00980	COG0659	secondary active sulfate transmembrane transporter activity
BW16_00985	COG0385	Bile acid
BW16_00990	COG3876	Protein conserved in bacteria
BW16_00995	COG1472	Belongs to the glycosyl hydrolase 3 family
BW16_01000	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
BW16_01005	COG1263	PTS System
BW16_01005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_01010	COG1737	Transcriptional regulator
BW16_01015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BW16_01050	COG1595	DNA-templated transcription, initiation
BW16_01055	COG5662	AntiSigma factor
BW16_01060	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BW16_01065	COG4856	YbbR-like protein
BW16_01070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW16_01075	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BW16_01095	COG1131	(ABC) transporter
BW16_01105	COG1136	(ABC) transporter
BW16_01115	COG1695	Transcriptional regulator
BW16_01125	COG1131	(ABC) transporter
BW16_01135	COG1413	lyase activity
BW16_01140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_01155	COG2311	Membrane
BW16_01175	COG1476	TRANSCRIPTIONal
BW16_01185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BW16_01190	COG2207	Transcriptional regulator
BW16_01195	COG1309	transcriptional regulator
BW16_01210	COG1113	amino acid transport
BW16_01215	COG0584	glycerophosphoryl diester phosphodiesterase
BW16_01220	COG2271	Major facilitator Superfamily
BW16_01230	COG1331	Highly conserved protein containing a thioredoxin domain
BW16_01255	COG0640	Transcriptional regulator
BW16_01270	COG1937	Protein conserved in bacteria
BW16_01275	COG2210	Belongs to the sulfur carrier protein TusA family
BW16_01285	COG0425	Belongs to the sulfur carrier protein TusA family
BW16_01285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_01290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_01295	COG0425	Belongs to the sulfur carrier protein TusA family
BW16_01300	COG0730	response to heat
BW16_01310	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW16_01320	COG2814	Major facilitator Superfamily
BW16_01335	COG1846	Transcriptional regulator
BW16_01345	COG1683	Conserved Protein
BW16_01355	COG0656	L-ascorbic acid biosynthetic process
BW16_01360	COG0371	Dehydrogenase
BW16_01370	COG0531	amino acid
BW16_01380	COG3711	transcriptional antiterminator
BW16_01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_01385	COG1263	PTS System
BW16_01385	COG2190	(PTS) system
BW16_01390	COG2723	6-phospho-beta-galactosidase activity
BW16_01410	COG2801	Transposase and inactivated derivatives
BW16_01420	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_01420	COG3711	transcriptional antiterminator
BW16_01425	COG1940	carbohydrate kinase activity
BW16_01430	COG0383	alpha-mannosidase activity
BW16_01435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_01440	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_01450	COG1404	Belongs to the peptidase S8 family
BW16_01465	COG0833	amino acid
BW16_01470	COG2040	homocysteine
BW16_01475	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_01480	COG1695	Transcriptional regulator
BW16_01495	COG2814	Major facilitator Superfamily
BW16_01520	COG1404	Belongs to the peptidase S8 family
BW16_01530	COG1309	transcriptional regulator
BW16_01535	COG1917	Cupin 2, conserved barrel domain protein
BW16_01540	COG1846	Transcriptional regulator
BW16_01545	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_01550	COG0531	amino acid
BW16_01560	COG0596	Alpha beta hydrolase
BW16_01565	COG1115	amino acid carrier protein
BW16_01570	COG2066	Belongs to the glutaminase family
BW16_01575	COG4191	Histidine kinase
BW16_01580	COG0784	Response regulator, receiver
BW16_01585	COG1405	negative regulation of cell septum assembly
BW16_01585	COG3012	SEC-C Motif Domain Protein
BW16_01595	COG0667	Aldo Keto reductase
BW16_01600	COG3290	protein histidine kinase activity
BW16_01605	COG3279	Response regulator of the LytR AlgR family
BW16_01610	COG4555	ABC transporter
BW16_01615	COG1668	transmembrane transport
BW16_01635	COG3773	Cell wall hydrolase
BW16_01640	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_01650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_01655	COG2310	stress, protein
BW16_01660	COG2310	stress, protein
BW16_01665	COG2310	stress, protein
BW16_01670	COG0861	Integral membrane protein TerC family
BW16_01700	COG3853	Toxic anion resistance protein (TelA)
BW16_01705	COG0517	IMP dehydrogenase activity
BW16_01705	COG4175	Glycine betaine
BW16_01710	COG4176	ABC-type proline glycine betaine transport system permease component
BW16_01715	COG2113	Glycine betaine
BW16_01730	COG1473	amidohydrolase
BW16_01735	COG1288	antiporter activity
BW16_01740	COG0039	L-malate dehydrogenase activity
BW16_01745	COG1620	l-lactate permease
BW16_01750	COG1609	Transcriptional regulator
BW16_01755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW16_01760	COG0561	phosphatase activity
BW16_01765	COG0673	inositol 2-dehydrogenase activity
BW16_01770	COG0738	Major facilitator superfamily
BW16_01775	COG1280	lysine exporter protein (LysE YggA)
BW16_01795	COG3403	YqcI/YcgG family
BW16_01800	COG1113	amino acid transport
BW16_01805	COG3665	Urea carboxylase-associated protein
BW16_01810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BW16_01820	COG1012	belongs to the aldehyde dehydrogenase family
BW16_01825	COG0710	3-dehydroquinate dehydratase activity
BW16_01830	COG0028	Belongs to the TPP enzyme family
BW16_01840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BW16_01845	COG2271	Major facilitator Superfamily
BW16_01855	COG1414	Transcriptional regulator
BW16_01860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BW16_01865	COG2226	methyltransferase
BW16_01870	COG0583	DNA-binding transcription factor activity
BW16_01875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW16_01880	COG3458	cephalosporin-C deacetylase activity
BW16_01890	COG3541	Predicted nucleotidyltransferase
BW16_01895	COG0506	proline dehydrogenase activity
BW16_01900	COG1012	belongs to the aldehyde dehydrogenase family
BW16_01905	COG2508	Transcriptional regulator
BW16_01910	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BW16_01915	COG0765	amino acid transport
BW16_01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_01930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BW16_01935	COG1522	sequence-specific DNA binding
BW16_01940	COG2746	aminoglycoside 3-N-acetyltransferase activity
BW16_01950	COG0840	transmembrane signaling receptor activity
BW16_01950	COG3290	protein histidine kinase activity
BW16_01955	COG3209	COG3209 Rhs family protein
BW16_01980	COG3842	ATPase activity
BW16_01985	COG1176	ABC-type spermidine putrescine transport system, permease component I
BW16_01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
BW16_02025	COG0697	spore germination
BW16_02030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_02040	COG2207	Transcriptional regulator
BW16_02040	COG3708	Transcriptional regulator
BW16_02050	COG2364	Membrane
BW16_02055	COG1126	abc transporter atp-binding protein
BW16_02060	COG0765	amino acid transport
BW16_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_02070	COG0412	Dienelactone hydrolase
BW16_02075	COG0833	amino acid
BW16_02080	COG3104	oligopeptide transport
BW16_02085	COG5434	Belongs to the glycosyl hydrolase 28 family
BW16_02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_02105	COG0765	amino acid transport
BW16_02110	COG1126	abc transporter atp-binding protein
BW16_02120	COG2079	MmgE PrpD family protein
BW16_02130	COG0745	RESPONSE REGULATOR receiver
BW16_02135	COG3850	Histidine kinase
BW16_02135	COG5002	protein histidine kinase activity
BW16_02140	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_02145	COG0527	aspartate kinase activity
BW16_02150	COG2814	Major facilitator Superfamily
BW16_02155	COG1309	transcriptional regulator
BW16_02160	COG0640	Transcriptional regulator
BW16_02170	COG0583	DNA-binding transcription factor activity
BW16_02175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_02180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BW16_02185	COG0531	amino acid
BW16_02190	COG1012	belongs to the aldehyde dehydrogenase family
BW16_02195	COG2249	NAD(P)H dehydrogenase (quinone) activity
BW16_02200	COG4549	nuclear export factor GLE1
BW16_02205	COG1276	copper resistance
BW16_02205	COG2372	response to copper ion
BW16_02210	COG2213	PTS system mannitol-specific
BW16_02215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_02220	COG0246	Mannitol dehydrogenase
BW16_02225	COG0840	transmembrane signaling receptor activity
BW16_02260	COG0346	lactoylglutathione lyase activity
BW16_02270	COG0561	phosphatase activity
BW16_02275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BW16_02280	COG1914	H( )-stimulated, divalent metal cation uptake system
BW16_02285	COG4336	lyase activity
BW16_02290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BW16_02295	COG1984	allophanate hydrolase subunit 2
BW16_02300	COG1414	Transcriptional regulator
BW16_02305	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_02315	COG2755	lipolytic protein G-D-S-L family
BW16_02325	COG3711	transcriptional antiterminator
BW16_02330	COG2226	methyltransferase
BW16_02335	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_02345	COG3871	stress protein (general stress protein 26)
BW16_02370	COG2814	Major facilitator Superfamily
BW16_02375	COG1802	Transcriptional regulator
BW16_02380	COG2207	Transcriptional regulator
BW16_02380	COG1917	Cupin 2, conserved barrel domain protein
BW16_02385	COG0697	spore germination
BW16_02390	COG0473	3-isopropylmalate dehydrogenase activity
BW16_02395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW16_02395	COG0551	DNA topoisomerase type I activity
BW16_02400	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BW16_02405	COG3706	GGDEF domain
BW16_02410	COG5298	Protein conserved in bacteria
BW16_02415	COG1215	transferase activity, transferring glycosyl groups
BW16_02425	COG0531	amino acid
BW16_02430	COG0028	Belongs to the TPP enzyme family
BW16_02435	COG5444	nuclease activity
BW16_02455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_02460	COG1914	H( )-stimulated, divalent metal cation uptake system
BW16_02465	COG2261	transglycosylase associated protein
BW16_02470	COG2217	Heavy metal translocating P-type atpase
BW16_02475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BW16_02480	COG3290	protein histidine kinase activity
BW16_02485	COG4565	transcriptional regulatory protein
BW16_02490	COG1301	dicarboxylic acid transport
BW16_02495	COG0628	permease
BW16_02500	COG1301	dicarboxylic acid transport
BW16_02505	COG1131	(ABC) transporter
BW16_02510	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BW16_02525	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_02530	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW16_02535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BW16_02550	COG0513	Belongs to the DEAD box helicase family
BW16_02555	COG3402	PFAM membrane-flanked domain
BW16_02560	COG3428	Bacterial PH domain
BW16_02565	COG0705	Rhomboid family
BW16_02570	COG0736	holo-[acyl-carrier-protein] synthase activity
BW16_02575	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BW16_02580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW16_02585	COG0864	Transcriptional regulator
BW16_02590	COG2337	Toxic component of a toxin-antitoxin (TA) module
BW16_02595	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_02600	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_02605	COG2172	sigma factor antagonist activity
BW16_02610	COG2208	phosphoserine phosphatase activity
BW16_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_02620	COG2172	sigma factor antagonist activity
BW16_02625	COG1191	sigma factor activity
BW16_02630	COG2208	phosphoserine phosphatase activity
BW16_02635	COG2183	response to ionizing radiation
BW16_02645	COG3091	SprT-like family
BW16_02650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_02655	COG0022	dehydrogenase e1 component
BW16_02660	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_02665	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_02670	COG3284	Transcriptional regulator
BW16_02710	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BW16_02725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_02730	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BW16_02730	COG0456	acetyltransferase
BW16_02735	COG1278	Cold shock
BW16_02745	COG1404	Belongs to the peptidase S8 family
BW16_02760	COG0789	Transcriptional regulator
BW16_02770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_02795	COG0477	Major facilitator Superfamily
BW16_02810	COG4221	oxidoreductase activity
BW16_02820	COG0252	asparaginase activity
BW16_02845	COG2814	Major facilitator Superfamily
BW16_02860	COG2801	Transposase and inactivated derivatives
BW16_02910	COG1309	transcriptional regulator
BW16_02915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW16_02920	COG1846	Transcriptional regulator
BW16_02925	COG0778	Nitroreductase
BW16_02945	COG1396	sequence-specific DNA binding
BW16_02955	COG0456	acetyltransferase
BW16_02965	COG4122	O-methyltransferase activity
BW16_02975	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BW16_02980	COG0697	spore germination
BW16_02990	COG1301	dicarboxylic acid transport
BW16_03030	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BW16_03035	COG0802	atpase or kinase
BW16_03040	COG1214	PFAM Peptidase M22, glycoprotease
BW16_03045	COG0456	acetyltransferase
BW16_03050	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BW16_03055	COG0488	(ABC) transporter
BW16_03060	COG0315	cyclic pyranopterin monophosphate synthase activity
BW16_03065	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BW16_03070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BW16_03075	COG0805	protein transport
BW16_03090	COG1266	CAAX protease self-immunity
BW16_03095	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BW16_03100	COG0459	protein refolding
BW16_03105	COG1846	Transcriptional regulator
BW16_03110	COG2808	Putative FMN-binding domain
BW16_03115	COG1876	peptidase activity
BW16_03140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BW16_03145	COG0823	Involved in the tonB-independent uptake of proteins
BW16_03155	COG2132	Multicopper oxidase
BW16_03160	COG1113	amino acid transport
BW16_03165	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW16_03170	COG0714	Associated with various cellular activities
BW16_03175	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
BW16_03180	COG1305	Transglutaminase-like
BW16_03185	COG0519	Catalyzes the synthesis of GMP from XMP
BW16_03185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW16_03190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BW16_03200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW16_03230	COG3279	Response regulator of the LytR AlgR family
BW16_03250	COG1595	DNA-templated transcription, initiation
BW16_03260	COG2814	Major facilitator Superfamily
BW16_03265	COG0583	DNA-binding transcription factor activity
BW16_03270	COG2252	PERMEase
BW16_03280	COG5583	Uncharacterized small protein (DUF2292)
BW16_03285	COG3064	Membrane
BW16_03290	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
BW16_03300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BW16_03305	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BW16_03310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BW16_03315	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BW16_03320	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW16_03325	COG0047	phosphoribosylformylglycinamidine synthase activity
BW16_03330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW16_03335	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BW16_03340	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BW16_03345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BW16_03350	COG0138	bifunctional purine biosynthesis protein purh
BW16_03355	COG0151	Belongs to the GarS family
BW16_03375	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BW16_03380	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BW16_03385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BW16_03390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW16_03400	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BW16_03405	COG4496	protein, YerC YecD
BW16_03415	COG0069	glutamate synthase activity
BW16_03430	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
BW16_03435	COG0210	DNA helicase
BW16_03440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BW16_03445	COG4851	CamS sex pheromone cAM373 precursor
BW16_03450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BW16_03455	COG1285	pathogenesis
BW16_03460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW16_03465	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW16_03470	COG0154	amidase activity
BW16_03475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW16_03480	COG1309	transcriptional regulator
BW16_03485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BW16_03490	COG1957	nucleoside hydrolase
BW16_03495	COG1597	lipid kinase activity
BW16_03500	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW16_03510	COG0514	ATP-dependent DNA helicase (RecQ)
BW16_03515	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BW16_03535	COG0492	ferredoxin-NADP+ reductase activity
BW16_03550	COG1486	melibiose metabolic process
BW16_03560	COG2211	Major facilitator Superfamily
BW16_03590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BW16_03595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW16_03600	COG1442	glycosyl transferase family 8
BW16_03605	COG1216	Glycosyl transferase, family 2
BW16_03610	COG1442	glycosyl transferase family 8
BW16_03615	COG2223	nitrite transmembrane transporter activity
BW16_03625	COG0471	metal ion transport
BW16_03640	COG0071	Belongs to the small heat shock protein (HSP20) family
BW16_03655	COG0531	amino acid
BW16_03660	COG0463	Glycosyl transferase, family 2
BW16_03660	COG0457	Tetratricopeptide repeat
BW16_03665	COG0488	(ABC) transporter
BW16_03670	COG1469	GTP cyclohydrolase I activity
BW16_03675	COG0789	Transcriptional regulator
BW16_03680	COG2814	Major facilitator Superfamily
BW16_03685	COG0488	(ABC) transporter
BW16_03690	COG0513	Belongs to the DEAD box helicase family
BW16_03715	COG2130	NADP-dependent
BW16_03740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_03740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_03745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BW16_03755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_03755	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_03765	COG3290	protein histidine kinase activity
BW16_03770	COG4565	transcriptional regulatory protein
BW16_03775	COG3181	Tripartite tricarboxylate transporter family receptor
BW16_03780	COG2851	Citrate transporter
BW16_03790	COG3479	Phenolic acid decarboxylase
BW16_03795	COG1695	Transcriptional regulator
BW16_03800	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
BW16_03810	COG1254	Belongs to the acylphosphatase family
BW16_03815	COG2258	MOSC domain
BW16_03830	COG0024	Methionine aminopeptidase
BW16_03835	COG1263	PTS System
BW16_03835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_03840	COG3739	integral membrane protein
BW16_03855	COG1368	sulfuric ester hydrolase activity
BW16_03860	COG0076	glutamate decarboxylase activity
BW16_03875	COG1263	PTS System
BW16_03875	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_03880	COG0366	Alpha amylase catalytic
BW16_03885	COG2188	Transcriptional regulator
BW16_03895	COG0737	Belongs to the 5'-nucleotidase family
BW16_03900	COG0693	protein deglycase activity
BW16_03905	COG4840	Belongs to the UPF0435 family
BW16_03910	COG1115	amino acid carrier protein
BW16_03920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW16_03925	COG4980	gas vesicle protein
BW16_03930	COG1295	ribonuclease BN
BW16_03940	COG0477	Major facilitator Superfamily
BW16_03950	COG0387	Pfam Sodium calcium exchanger
BW16_03960	COG0217	transcriptional regulatory protein
BW16_03970	COG0668	transmembrane transport
BW16_03975	COG0535	radical SAM domain protein
BW16_03985	COG0726	polysaccharide deacetylase
BW16_03995	COG0598	Magnesium transport protein CorA
BW16_04005	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BW16_04010	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW16_04075	COG0789	Transcriptional regulator
BW16_04080	COG2814	Major facilitator Superfamily
BW16_04095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW16_04140	COG2076	Multidrug Resistance protein
BW16_04145	COG2076	Multidrug Resistance protein
BW16_04150	COG1309	transcriptional regulator
BW16_04160	COG4637	Psort location Cytoplasmic, score
BW16_04165	COG2755	lipolytic protein G-D-S-L family
BW16_04170	COG0492	ferredoxin-NADP+ reductase activity
BW16_04175	COG2169	Transcriptional regulator
BW16_04180	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BW16_04185	COG1132	(ABC) transporter
BW16_04190	COG1742	UPF0060 membrane protein
BW16_04195	COG1595	DNA-templated transcription, initiation
BW16_04220	COG2318	DinB family
BW16_04230	COG1846	Transcriptional regulator
BW16_04235	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BW16_04235	COG0392	lysyltransferase activity
BW16_04255	COG0778	Nitroreductase
BW16_04270	COG1090	epimerase
BW16_04275	COG2137	regulation of response to DNA damage stimulus
BW16_04300	COG0463	Glycosyl transferase, family 2
BW16_04305	COG4485	Bacterial membrane protein, YfhO
BW16_04310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BW16_04325	COG2140	Oxalate decarboxylase
BW16_04335	COG1191	sigma factor activity
BW16_04345	COG1988	membrane-bound metal-dependent
BW16_04350	COG1194	a g-specific adenine glycosylase
BW16_04360	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_04375	COG3557	Belongs to the UPF0374 family
BW16_04380	COG1132	(ABC) transporter
BW16_04385	COG0444	Belongs to the ABC transporter superfamily
BW16_04390	COG4608	Belongs to the ABC transporter superfamily
BW16_04395	COG0747	negative chemotaxis
BW16_04410	COG4129	membrane
BW16_04415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW16_04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BW16_04425	COG0735	belongs to the Fur family
BW16_04580	COG1368	sulfuric ester hydrolase activity
BW16_04585	COG0681	Belongs to the peptidase S26 family
BW16_04610	COG1131	(ABC) transporter
BW16_04640	COG3382	B3 4 domain protein
BW16_04645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BW16_04655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BW16_04670	COG2766	serine protein kinase
BW16_04675	COG2718	Belongs to the UPF0229 family
BW16_04680	COG1566	PFAM secretion protein HlyD family protein
BW16_04685	COG2814	Major facilitator Superfamily
BW16_04690	COG0655	NAD(P)H dehydrogenase (quinone) activity
BW16_04700	COG1278	Cold shock
BW16_04705	COG3706	GGDEF domain
BW16_04730	COG5577	PFAM Coat F domain
BW16_04735	COG5002	protein histidine kinase activity
BW16_04740	COG4085	toxin activity
BW16_04740	COG1525	nuclease
BW16_04740	COG0737	Belongs to the 5'-nucleotidase family
BW16_04745	COG3764	Sortase (surface protein transpeptidase)
BW16_04750	COG0564	pseudouridine synthase activity
BW16_04765	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BW16_04770	COG3153	acetyltransferase
BW16_04770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW16_04790	COG3835	regulator
BW16_04795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BW16_04800	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BW16_04805	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BW16_04810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BW16_04815	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BW16_04820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW16_04825	COG2203	Gaf domain
BW16_04825	COG4585	Histidine kinase
BW16_04830	COG2197	response regulator
BW16_04845	COG0753	catalase activity
BW16_04850	COG1959	2 iron, 2 sulfur cluster binding
BW16_04855	COG1017	nitric oxide dioxygenase activity
BW16_04855	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BW16_04860	COG2719	SpoVR family
BW16_04865	COG1785	Belongs to the alkaline phosphatase family
BW16_04870	COG0791	NLP P60 protein
BW16_04870	COG1388	LysM domain
BW16_04875	COG0531	amino acid
BW16_04890	COG1595	DNA-templated transcription, initiation
BW16_04895	COG0204	Acyl-transferase
BW16_04900	COG1253	flavin adenine dinucleotide binding
BW16_04905	COG0789	Transcriptional regulator
BW16_04910	COG1253	flavin adenine dinucleotide binding
BW16_04925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW16_04930	COG0584	glycerophosphoryl diester phosphodiesterase
BW16_04940	COG0668	transmembrane transport
BW16_04945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW16_04950	COG0726	polysaccharide deacetylase
BW16_04955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_04960	COG0589	response to stress
BW16_04980	COG1132	(ABC) transporter
BW16_04985	COG1132	(ABC) transporter
BW16_04990	COG0702	epimerase
BW16_05005	COG3842	ATPase activity
BW16_05010	COG2508	Transcriptional regulator
BW16_05020	COG0189	ligase activity
BW16_05025	COG0189	ligase activity
BW16_05030	COG4399	Belongs to the UPF0754 family
BW16_05035	COG3679	Belongs to the UPF0342 family
BW16_05040	COG0561	phosphatase activity
BW16_05045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BW16_05055	COG0475	glutathione-regulated potassium exporter activity
BW16_05060	COG0490	domain, Protein
BW16_05070	COG1024	Enoyl-CoA hydratase
BW16_05080	COG0420	3'-5' exonuclease activity
BW16_05085	COG4717	serine-type aminopeptidase activity
BW16_05090	COG3481	metal-dependent phosphohydrolase, HD sub domain
BW16_05100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BW16_05125	COG1846	Transcriptional regulator
BW16_05130	COG4980	gas vesicle protein
BW16_05145	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BW16_05150	COG0537	adenosine 5'-monophosphoramidase activity
BW16_05160	COG1131	(ABC) transporter
BW16_05165	COG4473	ABC transporter
BW16_05175	COG1473	amidohydrolase
BW16_05185	COG2329	Antibiotic biosynthesis monooxygenase
BW16_05190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_05195	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BW16_05210	COG1309	transcriptional regulator
BW16_05215	COG1511	domain protein
BW16_05220	COG1363	Peptidase, m42
BW16_05225	COG1301	dicarboxylic acid transport
BW16_05235	COG1234	tRNA 3'-trailer cleavage
BW16_05240	COG0095	Lipoate-protein ligase
BW16_05245	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_05255	COG0501	Belongs to the peptidase M48B family
BW16_05260	COG1404	Belongs to the peptidase S8 family
BW16_05265	COG0406	alpha-ribazole phosphatase activity
BW16_05270	COG0840	transmembrane signaling receptor activity
BW16_05275	COG0723	plastoquinol--plastocyanin reductase activity
BW16_05275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW16_05280	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_05290	COG4903	ComK protein
BW16_05295	COG4974	Belongs to the 'phage' integrase family
BW16_05300	COG2856	Zn peptidase
BW16_05310	COG1396	sequence-specific DNA binding
BW16_05360	COG5377	YqaJ viral recombinase family
BW16_05365	COG3723	Recombinational DNA repair protein, rece pathway
BW16_05380	COG1484	DNA-dependent DNA replication
BW16_05395	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BW16_05440	COG3677	Transposase
BW16_05455	COG5484	DNA packaging
BW16_05560	COG5632	N-Acetylmuramoyl-L-alanine amidase
BW16_05560	COG3409	Peptidoglycan-binding domain 1 protein
BW16_05590	COG0328	RNA-DNA hybrid ribonuclease activity
BW16_05600	COG4903	ComK protein
BW16_05615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_05620	COG2814	Major facilitator Superfamily
BW16_05625	COG2732	(Barnase) inhibitor
BW16_05630	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_05635	COG4605	iron ion homeostasis
BW16_05640	COG4604	ABC transporter, ATP-binding protein
BW16_05645	COG4607	ABC-type enterochelin transport system periplasmic component
BW16_05650	COG1316	TRANSCRIPTIONal
BW16_05665	COG0398	Pfam SNARE associated Golgi protein
BW16_05670	COG0681	Belongs to the peptidase S26 family
BW16_05675	COG3180	Ammonia monooxygenase
BW16_05690	COG2259	Doxx family
BW16_05695	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BW16_05700	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BW16_05705	COG1074	ATP-dependent DNA helicase activity
BW16_05710	COG0420	3'-5' exonuclease activity
BW16_05715	COG0419	ATPase involved in DNA repair
BW16_05720	COG1403	HNH endonuclease
BW16_05760	COG5337	Spore coat protein CotH
BW16_05775	COG0179	Fumarylacetoacetate (FAA) hydrolase
BW16_05790	COG0367	asparagine synthase
BW16_05805	COG1562	ergosterol biosynthetic process
BW16_05815	COG0534	Mate efflux family protein
BW16_05820	COG2207	Transcriptional regulator
BW16_05820	COG1917	Cupin 2, conserved barrel domain protein
BW16_05845	COG0076	glutamate decarboxylase activity
BW16_05880	COG0646	methionine synthase
BW16_05880	COG1410	methionine synthase
BW16_05885	COG0646	methionine synthase
BW16_05885	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BW16_05890	COG1666	GTP binding
BW16_05895	COG2996	Protein conserved in bacteria
BW16_05905	COG0840	transmembrane signaling receptor activity
BW16_05910	COG1307	EDD domain protein, DegV family
BW16_05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_05935	COG0561	phosphatase activity
BW16_05940	COG1073	alpha beta
BW16_05945	COG2151	metal-sulfur cluster biosynthetic enzyme
BW16_05950	COG0277	FAD linked oxidase domain protein
BW16_05955	COG2271	Major facilitator Superfamily
BW16_05960	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BW16_05970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BW16_05975	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW16_05980	COG0505	Belongs to the CarA family
BW16_05985	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW16_05990	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW16_06000	COG2814	Major facilitator Superfamily
BW16_06015	COG2267	carboxylic ester hydrolase activity
BW16_06025	COG1744	ABC transporter substrate-binding protein PnrA-like
BW16_06040	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW16_06045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BW16_06050	COG5504	Zn-dependent protease
BW16_06055	COG0444	Belongs to the ABC transporter superfamily
BW16_06060	COG4608	Belongs to the ABC transporter superfamily
BW16_06070	COG0601	transmembrane transport
BW16_06075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_06085	COG0180	Tryptophanyl-tRNA synthetase
BW16_06090	COG4166	transmembrane transport
BW16_06095	COG0601	transmembrane transport
BW16_06100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_06105	COG0444	Belongs to the ABC transporter superfamily
BW16_06110	COG4608	Belongs to the ABC transporter superfamily
BW16_06120	COG0456	acetyltransferase
BW16_06125	COG1393	Belongs to the ArsC family
BW16_06130	COG0861	Integral membrane protein TerC family
BW16_06135	COG4862	establishment of competence for transformation
BW16_06140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_06150	COG1164	Oligoendopeptidase f
BW16_06165	COG2346	COG2346, Truncated hemoglobins
BW16_06170	COG0741	lytic transglycosylase activity
BW16_06175	COG4116	CYTH
BW16_06185	COG2357	RelA SpoT domain protein
BW16_06190	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW16_06195	COG0564	pseudouridine synthase activity
BW16_06200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BW16_06205	COG0569	domain protein
BW16_06205	COG0475	glutathione-regulated potassium exporter activity
BW16_06210	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW16_06215	COG0352	thiamine-phosphate diphosphorylase activity
BW16_06225	COG2104	thiamine diphosphate biosynthetic process
BW16_06230	COG2022	thiamine diphosphate biosynthetic process
BW16_06235	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BW16_06240	COG0351	phosphomethylpyrimidine kinase
BW16_06245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BW16_06305	COG0210	DNA helicase
BW16_06315	COG2153	protein acetylation
BW16_06320	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BW16_06325	COG2382	esterase
BW16_06330	COG0626	cystathionine gamma-synthase activity
BW16_06335	COG0626	cystathionine gamma-synthase activity
BW16_06345	COG0825	malonyl-CoA metabolic process
BW16_06360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_06365	COG2807	transmembrane transport
BW16_06375	COG0583	DNA-binding transcription factor activity
BW16_06390	COG0457	Tetratricopeptide repeat
BW16_06405	COG2153	protein acetylation
BW16_06410	COG2364	Membrane
BW16_06430	COG0300	oxidoreductase activity
BW16_06445	COG3173	Aminoglycoside phosphotransferase
BW16_06450	COG0583	DNA-binding transcription factor activity
BW16_06470	COG0583	DNA-binding transcription factor activity
BW16_06475	COG2807	transmembrane transport
BW16_06495	COG0457	Tetratricopeptide repeat
BW16_06525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW16_06535	COG1309	transcriptional regulator
BW16_06545	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_06550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_06555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_06575	COG4195	phage-related replication protein
BW16_06580	COG2856	Zn peptidase
BW16_06605	COG0306	phosphate transporter
BW16_06610	COG1392	Phosphate transport regulator
BW16_06620	COG0405	Gamma-glutamyltransferase
BW16_06625	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BW16_06635	COG4208	sulfate ABC transporter
BW16_06640	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BW16_06650	COG3775	system Galactitol-specific IIC component
BW16_06665	COG1063	alcohol dehydrogenase
BW16_06670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_06675	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_06675	COG0022	dehydrogenase e1 component
BW16_06680	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_06685	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_06690	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_06695	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_06700	COG2390	Transcriptional regulator
BW16_06710	COG0531	amino acid
BW16_06715	COG0346	lactoylglutathione lyase activity
BW16_06720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_06725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_06730	COG2362	D-Aminopeptidase
BW16_06735	COG0601	transmembrane transport
BW16_06740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_06745	COG0444	Belongs to the ABC transporter superfamily
BW16_06750	COG4166	transmembrane transport
BW16_06760	COG1619	proteins homologs of microcin C7 resistance protein MccF
BW16_06765	COG4948	Mandelate Racemase Muconate Lactonizing
BW16_06770	COG0791	NLP P60 protein
BW16_06775	COG4608	Belongs to the ABC transporter superfamily
BW16_06780	COG1834	amidinotransferase
BW16_06785	COG1607	acyl-coa hydrolase
BW16_06790	COG1695	Transcriptional regulator
BW16_06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_06815	COG2076	Multidrug Resistance protein
BW16_06820	COG2076	Multidrug Resistance protein
BW16_06830	COG0788	formyltetrahydrofolate deformylase activity
BW16_06835	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW16_06840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW16_06845	COG0457	Tetratricopeptide repeat
BW16_06855	COG1764	response to oxidative stress
BW16_06860	COG1846	Transcriptional regulator
BW16_06865	COG1764	response to oxidative stress
BW16_06870	COG0590	tRNA wobble adenosine to inosine editing
BW16_06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BW16_06880	COG1404	Belongs to the peptidase S8 family
BW16_06895	COG0745	RESPONSE REGULATOR receiver
BW16_06900	COG3850	Histidine kinase
BW16_06900	COG5002	protein histidine kinase activity
BW16_06905	COG3212	peptidase
BW16_06910	COG3212	peptidase
BW16_06930	COG2239	Acts as a magnesium transporter
BW16_06940	COG0583	DNA-binding transcription factor activity
BW16_06950	COG0789	Transcriptional regulator
BW16_06965	COG1846	Transcriptional regulator
BW16_06970	COG3300	MHYT domain
BW16_06970	COG5001	Diguanylate cyclase
BW16_06975	COG0586	Pfam SNARE associated Golgi protein
BW16_06980	COG0861	Integral membrane protein TerC family
BW16_06985	COG1191	sigma factor activity
BW16_07005	COG0501	Belongs to the peptidase M48B family
BW16_07010	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BW16_07015	COG2323	membrane
BW16_07030	COG3594	Acyltransferase
BW16_07035	COG5002	protein histidine kinase activity
BW16_07040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BW16_07050	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BW16_07055	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BW16_07060	COG0436	Aminotransferase
BW16_07065	COG1850	ribulose-bisphosphate carboxylase activity
BW16_07070	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BW16_07075	COG0235	Class ii aldolase
BW16_07080	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BW16_07090	COG3852	Histidine kinase
BW16_07095	COG1846	Transcriptional regulator
BW16_07100	COG1360	Flagellar Motor Protein
BW16_07105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BW16_07115	COG0542	response to heat
BW16_07120	COG3949	Membrane
BW16_07130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BW16_07135	COG0720	synthase
BW16_07140	COG0602	queuosine metabolic process
BW16_07145	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BW16_07155	COG4873	Protein conserved in bacteria
BW16_07165	COG3773	Cell wall hydrolase
BW16_07170	COG2244	polysaccharide biosynthetic process
BW16_07175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_07180	COG2217	Heavy metal translocating P-type atpase
BW16_07185	COG0006	proline dipeptidase activity
BW16_07195	COG1609	Transcriptional regulator
BW16_07200	COG3711	transcriptional antiterminator
BW16_07205	COG2190	(PTS) system
BW16_07205	COG1263	PTS System
BW16_07205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_07210	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_07215	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW16_07225	COG1533	DNA photolyase activity
BW16_07230	COG0840	transmembrane signaling receptor activity
BW16_07240	COG2084	Dehydrogenase
BW16_07245	COG2340	Cysteine-rich secretory protein family
BW16_07250	COG0768	penicillin binding
BW16_07255	COG4191	Histidine kinase
BW16_07260	COG0436	Aminotransferase
BW16_07265	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BW16_07275	COG1714	RDD family
BW16_07285	COG0784	Response regulator, receiver
BW16_07285	COG0835	chemotaxis
BW16_07295	COG1917	Cupin 2, conserved barrel domain protein
BW16_07295	COG2207	Transcriptional regulator
BW16_07300	COG0697	spore germination
BW16_07315	COG2814	Major facilitator Superfamily
BW16_07320	COG1376	ErfK ybiS ycfS ynhG family protein
BW16_07325	COG1408	metallophosphoesterase
BW16_07330	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_07335	COG2200	EAL domain
BW16_07340	COG3546	catalase activity
BW16_07345	COG4703	Protein of unknown function (DUF1797)
BW16_07350	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
BW16_07360	COG0517	IMP dehydrogenase activity
BW16_07365	COG0583	DNA-binding transcription factor activity
BW16_07375	COG0716	FMN binding
BW16_07385	COG0716	FMN binding
BW16_07390	COG2171	N-acyltransferase activity
BW16_07395	COG1473	amidohydrolase
BW16_07415	COG0668	transmembrane transport
BW16_07420	COG0450	alkyl hydroperoxide reductase
BW16_07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_07440	COG0746	molybdenum cofactor guanylyltransferase activity
BW16_07445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BW16_07450	COG0303	'Molybdopterin
BW16_07455	COG1763	Mo-molybdopterin cofactor biosynthetic process
BW16_07460	COG0314	molybdopterin synthase activity
BW16_07465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BW16_07480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BW16_07485	COG1136	(ABC) transporter
BW16_07490	COG0577	efflux transmembrane transporter activity
BW16_07495	COG1349	DNA-binding transcription factor activity
BW16_07500	COG1105	Belongs to the carbohydrate kinase PfkB family
BW16_07505	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_07505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_07505	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_07510	COG0681	Belongs to the peptidase S26 family
BW16_07520	COG0488	(ABC) transporter
BW16_07535	COG2309	aminopeptidase activity
BW16_07545	COG1077	Cell shape determining protein MreB Mrl
BW16_07550	COG2002	toxin-antitoxin pair type II binding
BW16_07555	COG3852	Histidine kinase
BW16_07560	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BW16_07560	COG2105	PFAM AIG2 family protein
BW16_07565	COG0569	domain protein
BW16_07575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BW16_07580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW16_07590	COG0561	phosphatase activity
BW16_07595	COG0242	peptide deformylase activity
BW16_07610	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_07615	COG0022	dehydrogenase e1 component
BW16_07620	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_07625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_07630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_07640	COG1982	Orn Lys Arg decarboxylase major
BW16_07645	COG4476	Belongs to the UPF0223 family
BW16_07650	COG4493	Belongs to the UPF0637 family
BW16_07660	COG0483	inositol monophosphate 1-phosphatase activity
BW16_07675	COG1595	DNA-templated transcription, initiation
BW16_07705	COG4896	Protein conserved in bacteria
BW16_07715	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BW16_07720	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BW16_07725	COG2066	Belongs to the glutaminase family
BW16_07730	COG4838	Belongs to the UPF0358 family
BW16_07735	COG0772	Belongs to the SEDS family
BW16_07740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BW16_07750	COG1612	heme a metabolic process
BW16_07755	COG0109	protoheme IX farnesyltransferase activity
BW16_07760	COG2010	Cytochrome c
BW16_07760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW16_07765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW16_07770	COG1845	cytochrome c oxidase, subunit III
BW16_07775	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BW16_07780	COG3336	cytochrome c oxidase
BW16_07790	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BW16_07795	COG2340	Cysteine-rich secretory protein family
BW16_07815	COG3679	Belongs to the UPF0342 family
BW16_07820	COG4471	UPF0298 protein
BW16_07825	COG0742	ribosomal rna small subunit methyltransferase
BW16_07830	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BW16_07835	COG3314	Sporulation integral membrane protein YlbJ
BW16_07840	COG1752	Esterase of the alpha-beta hydrolase superfamily
BW16_07845	COG3480	Lon protease (S16) C-terminal proteolytic domain
BW16_07855	COG1399	metal-binding, possibly nucleic acid-binding protein
BW16_07860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BW16_07870	COG0454	-acetyltransferase
BW16_07875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BW16_07880	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BW16_07885	COG2001	Belongs to the MraZ family
BW16_07890	COG0275	rRNA processing
BW16_07895	COG4839	cell division protein FtsL
BW16_07905	COG0768	penicillin binding
BW16_07910	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BW16_07920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW16_07925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW16_07930	COG0772	Belongs to the SEDS family
BW16_07935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW16_07940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BW16_07945	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BW16_07950	COG3879	Bacterial protein of unknown function (DUF881)
BW16_07955	COG3879	Bacterial protein of unknown function (DUF881)
BW16_07960	COG3856	small basic protein
BW16_07965	COG0849	cell division
BW16_07970	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BW16_07975	COG1404	Belongs to the peptidase S8 family
BW16_07975	COG4412	M6 family metalloprotease domain protein
BW16_07985	COG1191	sigma factor activity
BW16_07990	COG1191	sigma factor activity
BW16_07995	COG2390	Transcriptional regulator
BW16_08010	COG3730	PTS system glucitol sorbitol-specific
BW16_08015	COG3732	PTS system glucitol sorbitol-specific
BW16_08025	COG1119	ATPase activity
BW16_08030	COG1873	PFAM PRC-barrel domain
BW16_08040	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BW16_08045	COG1799	cell septum assembly
BW16_08050	COG0762	integral membrane protein
BW16_08055	COG2302	S4 RNA-binding domain
BW16_08060	COG3599	regulation of cell shape
BW16_08065	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BW16_08070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BW16_08075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW16_08080	COG0564	pseudouridine synthase activity
BW16_08090	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BW16_08095	COG2233	PERMEase
BW16_08100	COG0540	Belongs to the ATCase OTCase family
BW16_08105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW16_08110	COG0505	Belongs to the CarA family
BW16_08115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BW16_08120	COG0543	2 iron, 2 sulfur cluster binding
BW16_08125	COG0167	dihydroorotate dehydrogenase activity
BW16_08130	COG0284	orotidine-5'-phosphate decarboxylase activity
BW16_08135	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW16_08145	COG0175	sulfate reduction
BW16_08150	COG0306	phosphate transporter
BW16_08155	COG2046	Belongs to the sulfate adenylyltransferase family
BW16_08160	COG0529	Catalyzes the synthesis of activated sulfate
BW16_08165	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BW16_08170	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
BW16_08175	COG1648	precorrin-2 dehydrogenase activity
BW16_08185	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BW16_08190	COG1561	YicC-like family, N-terminal region
BW16_08195	COG2052	Domain of unknown function (DUF370)
BW16_08200	COG0194	GDP metabolic process
BW16_08205	COG1758	RNA polymerase activity
BW16_08210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BW16_08215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BW16_08220	COG0242	peptide deformylase activity
BW16_08225	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BW16_08230	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BW16_08230	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW16_08235	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BW16_08240	COG0631	protein serine/threonine phosphatase activity
BW16_08245	COG0515	serine threonine protein kinase
BW16_08245	COG2815	serine threonine protein kinase
BW16_08250	COG1162	GTPase activity
BW16_08255	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW16_08260	COG1564	THIamine pyrophosphokinase
BW16_08270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BW16_08275	COG1302	Protein conserved in bacteria
BW16_08280	COG1461	Dihydroxyacetone kinase
BW16_08285	COG1760	l-serine dehydratase
BW16_08290	COG1760	l-serine dehydratase
BW16_08295	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BW16_08300	COG1349	DNA-binding transcription factor activity
BW16_08305	COG0416	fatty acid biosynthetic process
BW16_08310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BW16_08315	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_08320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW16_08330	COG1196	nuclear chromosome segregation
BW16_08335	COG0552	protein localization to endoplasmic reticulum
BW16_08340	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BW16_08345	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BW16_08350	COG0228	four-way junction DNA binding
BW16_08355	COG1837	Belongs to the UPF0109 family
BW16_08365	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BW16_08370	COG0336	Belongs to the RNA methyltransferase TrmD family
BW16_08375	COG0335	large ribosomal subunit rRNA binding
BW16_08380	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BW16_08385	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW16_08395	COG2257	FlhB HrpN YscU SpaS Family
BW16_08400	COG0045	succinate-CoA ligase (ADP-forming) activity
BW16_08405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BW16_08410	COG0758	DNA mediated transformation
BW16_08415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW16_08420	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BW16_08425	COG4974	Belongs to the 'phage' integrase family
BW16_08430	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BW16_08435	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BW16_08440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BW16_08445	COG1815	bacterial-type flagellum-dependent cell motility
BW16_08450	COG1558	bacterial-type flagellum-dependent cell motility
BW16_08455	COG1677	Flagellar hook-basal body complex protein FliE
BW16_08460	COG1766	The M ring may be actively involved in energy transduction
BW16_08465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW16_08470	COG1317	bacterial-type flagellum organization
BW16_08475	COG1157	protein secretion by the type III secretion system
BW16_08480	COG2882	bacterial-type flagellum organization
BW16_08485	COG3334	PFAM MgtE intracellular
BW16_08490	COG3144	bacterial-type flagellum assembly
BW16_08495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BW16_08500	COG4786	Flagellar basal body rod
BW16_08505	COG1582	Flagellar protein (FlbD)
BW16_08510	COG1580	Controls the rotational direction of flagella during chemotaxis
BW16_08515	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW16_08520	COG1776	CheC inhibitor of MCP methylation
BW16_08520	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW16_08525	COG2201	protein-glutamate methylesterase activity
BW16_08530	COG3190	flagellar
BW16_08535	COG1338	Plays a role in the flagellum-specific transport system
BW16_08540	COG1987	bacterial-type flagellum assembly
BW16_08545	COG1684	flagellar biosynthetic protein fliR
BW16_08550	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BW16_08555	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BW16_08560	COG1419	protein localization to endoplasmic reticulum
BW16_08565	COG0455	bacterial-type flagellum organization
BW16_08570	COG2201	protein-glutamate methylesterase activity
BW16_08575	COG2198	Histidine kinase
BW16_08575	COG0643	Histidine kinase
BW16_08580	COG0835	chemotaxis
BW16_08585	COG1776	CheC inhibitor of MCP methylation
BW16_08595	COG1191	sigma factor activity
BW16_08610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BW16_08615	COG0528	UMP kinase activity
BW16_08620	COG0233	cytoplasmic translational termination
BW16_08625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW16_08630	COG4589	Belongs to the CDS family
BW16_08635	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BW16_08640	COG0750	zinc metalloprotease
BW16_08645	COG0442	prolyl-tRNA aminoacylation
BW16_08675	COG0779	Required for maturation of 30S ribosomal subunits
BW16_08680	COG0195	Participates in both transcription termination and antitermination
BW16_08685	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BW16_08690	COG1358	cellular component organization or biogenesis
BW16_08695	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BW16_08700	COG1550	Protein conserved in bacteria
BW16_08705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BW16_08710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BW16_08715	COG0196	riboflavin kinase activity
BW16_08720	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BW16_08725	COG1185	polyribonucleotide nucleotidyltransferase activity
BW16_08730	COG0726	polysaccharide deacetylase
BW16_08735	COG0612	Peptidase, M16
BW16_08745	COG1873	PFAM PRC-barrel domain
BW16_08750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW16_08755	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BW16_08760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BW16_08765	COG0527	aspartate kinase activity
BW16_08775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BW16_08780	COG0740	serine-type endopeptidase activity
BW16_08790	COG1674	ftsk spoiiie
BW16_08790	COG4980	gas vesicle protein
BW16_08795	COG2188	Transcriptional regulator
BW16_08800	COG2814	Major facilitator Superfamily
BW16_08805	COG2409	Drug exporters of the RND superfamily
BW16_08805	COG1033	growth of symbiont in host cell
BW16_08810	COG0612	Peptidase, M16
BW16_08815	COG0612	Peptidase, M16
BW16_08825	COG1033	growth of symbiont in host cell
BW16_08825	COG2409	Drug exporters of the RND superfamily
BW16_08845	COG1426	Protein conserved in bacteria
BW16_08850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BW16_08855	COG1058	Belongs to the CinA family
BW16_08855	COG1546	Belongs to the CinA family
BW16_08860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BW16_08865	COG1418	mRNA catabolic process
BW16_08870	COG1692	metallophosphoesterase
BW16_08875	COG2359	stage V sporulation protein S
BW16_08880	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BW16_08885	COG1063	alcohol dehydrogenase
BW16_08890	COG0156	8-amino-7-oxononanoate synthase activity
BW16_08900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW16_08905	COG4550	Control of competence regulator ComK, YlbF/YmcA
BW16_08915	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BW16_08920	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BW16_08945	COG1329	Transcriptional regulator
BW16_08950	COG4195	phage-related replication protein
BW16_08955	COG0457	Tetratricopeptide repeat
BW16_08960	COG1404	Belongs to the peptidase S8 family
BW16_08965	COG4195	phage-related replication protein
BW16_08970	COG1764	response to oxidative stress
BW16_09000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BW16_09005	COG1923	regulation of RNA biosynthetic process
BW16_09020	COG1780	Probably involved in ribonucleotide reductase function
BW16_09025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW16_09030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BW16_09035	COG4112	unkown
BW16_09045	COG0464	growth
BW16_09055	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BW16_09060	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BW16_09065	COG0789	Transcriptional regulator
BW16_09070	COG0174	glutamine synthetase
BW16_09090	COG0457	Tetratricopeptide repeat
BW16_09120	COG5444	nuclease activity
BW16_09150	COG5646	InterPro IPR014922
BW16_09170	COG0457	Tetratricopeptide repeat
BW16_09185	COG3619	membrane
BW16_09190	COG3285	dna ligase
BW16_09190	COG1793	dna ligase
BW16_09195	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BW16_09200	COG4876	unkown
BW16_09210	COG1959	2 iron, 2 sulfur cluster binding
BW16_09215	COG0702	epimerase
BW16_09220	COG0247	lactate metabolic process
BW16_09225	COG1139	Iron-sulfur cluster binding protein
BW16_09230	COG1556	Lactate utilization protein
BW16_09250	COG2323	membrane
BW16_09255	COG1309	transcriptional regulator
BW16_09260	COG2124	cytochrome p450
BW16_09260	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BW16_09265	COG3591	Belongs to the peptidase S1B family
BW16_09270	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BW16_09275	COG3209	COG3209 Rhs family protein
BW16_09280	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_09295	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW16_09300	COG1388	LysM domain
BW16_09305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BW16_09310	COG4224	UPF0291 protein
BW16_09315	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BW16_09325	COG3763	UPF0154 protein
BW16_09335	COG0785	Cytochrome C biogenesis protein
BW16_09340	COG4846	Membrane protein involved in cytochrome C biogenesis
BW16_09350	COG0071	Belongs to the small heat shock protein (HSP20) family
BW16_09365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BW16_09370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_09390	COG0824	Thioesterase
BW16_09400	COG4841	protein insertion into membrane
BW16_09405	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BW16_09410	COG1832	CoA-binding protein
BW16_09415	COG0187	DNA topoisomerase II activity
BW16_09420	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW16_09435	COG0738	Major facilitator superfamily
BW16_09440	COG0473	3-isopropylmalate dehydrogenase activity
BW16_09445	COG0110	maltose O-acetyltransferase activity
BW16_09450	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW16_09455	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BW16_09460	COG0640	Transcriptional regulator
BW16_09475	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BW16_09480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_09490	COG1309	transcriptional regulator
BW16_09495	COG2249	NAD(P)H dehydrogenase (quinone) activity
BW16_09500	COG1733	regulation of RNA biosynthetic process
BW16_09510	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_09515	COG0251	oxidation-reduction process
BW16_09550	COG0657	acetylesterase activity
BW16_09555	COG0789	Transcriptional regulator
BW16_09560	COG2723	6-phospho-beta-galactosidase activity
BW16_09565	COG1263	PTS System
BW16_09565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_09565	COG2190	(PTS) system
BW16_09580	COG2205	protein histidine kinase activity
BW16_09585	COG0745	RESPONSE REGULATOR receiver
BW16_09595	COG3507	Belongs to the glycosyl hydrolase 43 family
BW16_09600	COG1012	belongs to the aldehyde dehydrogenase family
BW16_09605	COG1486	melibiose metabolic process
BW16_09635	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW16_09650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_09660	COG0456	acetyltransferase
BW16_09665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_09695	COG1846	Transcriptional regulator
BW16_09700	COG2814	Major facilitator Superfamily
BW16_09710	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_09710	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_09710	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_09715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_09715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BW16_09715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_09720	COG1105	Belongs to the carbohydrate kinase PfkB family
BW16_09730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_09765	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
BW16_09780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW16_09785	COG1024	Enoyl-CoA hydratase
BW16_09795	COG0511	ligase activity, forming carbon-carbon bonds
BW16_09800	COG0439	Biotin carboxylase
BW16_09805	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_09810	COG1960	acyl-CoA dehydrogenase activity
BW16_09815	COG1649	PFAM Uncharacterised BCR, COG1649
BW16_09825	COG1349	DNA-binding transcription factor activity
BW16_09830	COG1942	4-Oxalocrotonate Tautomerase
BW16_09840	COG3835	regulator
BW16_09845	COG0277	FAD linked oxidase domain protein
BW16_09850	COG0247	lactate metabolic process
BW16_09870	COG0166	Belongs to the GPI family
BW16_09875	COG2246	polysaccharide biosynthetic process
BW16_09880	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BW16_09885	COG0586	Pfam SNARE associated Golgi protein
BW16_09890	COG1587	Uroporphyrinogen-III synthase
BW16_09900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_09915	COG0534	Mate efflux family protein
BW16_09920	COG2027	D-alanyl-D-alanine carboxypeptidase
BW16_09925	COG4677	pectinesterase activity
BW16_09930	COG2323	membrane
BW16_09935	COG2146	nitrite reductase [NAD(P)H] activity
BW16_09940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BW16_09945	COG0243	molybdopterin cofactor binding
BW16_09950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BW16_09955	COG2223	nitrite transmembrane transporter activity
BW16_09960	COG0493	'glutamate synthase
BW16_09965	COG0069	glutamate synthase activity
BW16_09965	COG0067	glutamate synthase
BW16_09965	COG0070	glutamate synthase
BW16_09970	COG0583	DNA-binding transcription factor activity
BW16_09980	COG1132	(ABC) transporter
BW16_09985	COG0789	Transcriptional regulator
BW16_09985	COG4978	Transcriptional regulator
BW16_09990	COG0454	-acetyltransferase
BW16_09995	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BW16_10000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BW16_10005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_10015	COG0243	molybdopterin cofactor binding
BW16_10025	COG1070	Carbohydrate kinase
BW16_10030	COG2115	Belongs to the xylose isomerase family
BW16_10035	COG1940	carbohydrate kinase activity
BW16_10045	COG2211	Major facilitator Superfamily
BW16_10050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_10055	COG1994	Peptidase M50
BW16_10080	COG1309	transcriptional regulator
BW16_10085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_10090	COG3708	Transcriptional regulator
BW16_10095	COG2378	regulation of single-species biofilm formation
BW16_10110	COG0640	Transcriptional regulator
BW16_10115	COG0531	amino acid
BW16_10120	COG0741	lytic transglycosylase activity
BW16_10125	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BW16_10130	COG2079	MmgE PrpD family protein
BW16_10135	COG0372	Belongs to the citrate synthase family
BW16_10140	COG2322	membrane
BW16_10155	COG3584	3D domain protein
BW16_10155	COG1388	LysM domain
BW16_10160	COG0514	ATP-dependent DNA helicase (RecQ)
BW16_10165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BW16_10190	COG1012	belongs to the aldehyde dehydrogenase family
BW16_10200	COG1657	PFAM Prenyltransferase squalene oxidase
BW16_10205	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BW16_10210	COG0385	Bile acid
BW16_10215	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_10225	COG4548	von Willebrand factor, type A
BW16_10230	COG0714	Associated with various cellular activities
BW16_10235	COG2032	superoxide dismutase activity
BW16_10240	COG0791	NLP P60 protein
BW16_10240	COG1388	LysM domain
BW16_10245	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BW16_10255	COG0534	Mate efflux family protein
BW16_10260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW16_10265	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW16_10275	COG2962	Rard protein
BW16_10290	COG1733	regulation of RNA biosynthetic process
BW16_10295	COG0778	Nitroreductase
BW16_10305	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW16_10310	COG0793	Belongs to the peptidase S41A family
BW16_10310	COG3409	Peptidoglycan-binding domain 1 protein
BW16_10315	COG2226	methyltransferase
BW16_10325	COG1876	peptidase activity
BW16_10330	COG0813	purine-nucleoside phosphorylase activity
BW16_10340	COG0671	phosphoesterase, PA-phosphatase related
BW16_10360	COG4479	Belongs to the UPF0346 family
BW16_10370	COG1509	lysine 2,3-aminomutase activity
BW16_10375	COG3829	transcription factor binding
BW16_10380	COG0463	Glycosyl transferase, family 2
BW16_10395	COG4641	Protein conserved in bacteria
BW16_10405	COG1086	Polysaccharide biosynthesis protein
BW16_10410	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW16_10415	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BW16_10420	COG1846	Transcriptional regulator
BW16_10440	COG4698	Protein conserved in bacteria
BW16_10445	COG2755	lipolytic protein G-D-S-L family
BW16_10450	COG1999	signal sequence binding
BW16_10465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BW16_10470	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
BW16_10475	COG1272	protein, Hemolysin III
BW16_10480	COG0204	Acyl-transferase
BW16_10485	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW16_10490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BW16_10495	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BW16_10510	COG2521	methyltransferase
BW16_10510	COG2136	Putative SAM-dependent methyltransferase
BW16_10520	COG0129	dihydroxy-acid dehydratase activity
BW16_10525	COG1413	lyase activity
BW16_10530	COG1418	mRNA catabolic process
BW16_10535	COG0386	Belongs to the glutathione peroxidase family
BW16_10540	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BW16_10550	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW16_10560	COG1278	Cold shock
BW16_10575	COG0328	RNA-DNA hybrid ribonuclease activity
BW16_10580	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BW16_10585	COG0328	RNA-DNA hybrid ribonuclease activity
BW16_10595	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW16_10610	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BW16_10615	COG1755	Isoprenylcysteine carboxyl methyltransferase
BW16_10620	COG3424	synthase
BW16_10625	COG0726	polysaccharide deacetylase
BW16_10630	COG2233	PERMEase
BW16_10635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW16_10640	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BW16_10645	COG1199	ATP-dependent helicase activity
BW16_10655	COG0116	Belongs to the methyltransferase superfamily
BW16_10660	COG3599	regulation of cell shape
BW16_10665	COG4474	Belongs to the UPF0398 family
BW16_10675	COG3359	exonuclease
BW16_10680	COG1111	helicase
BW16_10680	COG1205	dead DEAH box helicase
BW16_10685	COG1902	pentaerythritol trinitrate reductase activity
BW16_10690	COG2190	(PTS) system
BW16_10695	COG0071	Belongs to the small heat shock protein (HSP20) family
BW16_10725	COG3331	DNA recombination
BW16_10730	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_10730	COG4499	WXG100 protein secretion system (Wss), protein YukC
BW16_10740	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BW16_10745	COG3935	DnaD domain protein
BW16_10750	COG0017	Asparaginyl-tRNA synthetase
BW16_10755	COG5353	protein conserved in bacteria
BW16_10765	COG1199	ATP-dependent helicase activity
BW16_10765	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BW16_10770	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BW16_10775	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BW16_10780	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BW16_10790	COG0617	tRNA 3'-terminal CCA addition
BW16_10795	COG0438	transferase activity, transferring glycosyl groups
BW16_10800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BW16_10805	COG1803	Methylglyoxal synthase
BW16_10810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BW16_10815	COG1694	Mazg nucleotide pyrophosphohydrolase
BW16_10820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_10830	COG4347	Protein of unknown function (DUF1405)
BW16_10835	COG2010	Cytochrome c
BW16_10835	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW16_10840	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BW16_10845	COG0723	plastoquinol--plastocyanin reductase activity
BW16_10855	COG5582	Belongs to the UPF0302 family
BW16_10860	COG0457	Tetratricopeptide repeat
BW16_10865	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BW16_10870	COG0287	Prephenate dehydrogenase
BW16_10875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BW16_10880	COG0159	tryptophan synthase activity
BW16_10885	COG0133	tryptophan synthase activity
BW16_10890	COG0135	phosphoribosylanthranilate isomerase activity
BW16_10895	COG0134	indole-3-glycerol-phosphate synthase activity
BW16_10900	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BW16_10910	COG4401	Chorismate mutase type I
BW16_10915	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BW16_10920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BW16_10925	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BW16_10930	COG0105	UTP biosynthetic process
BW16_10935	COG0142	geranyltranstransferase activity
BW16_10940	COG2226	methyltransferase
BW16_10945	COG0142	geranyltranstransferase activity
BW16_10955	COG0302	gtp cyclohydrolase
BW16_10960	COG0776	regulation of translation
BW16_10965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BW16_10980	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BW16_10985	COG1160	GTP binding
BW16_11010	COG1304	FMN binding
BW16_11015	COG0539	negative regulation of cytoplasmic translation
BW16_11020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BW16_11030	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
BW16_11035	COG2959	enzyme of heme biosynthesis
BW16_11040	COG3773	Cell wall hydrolase
BW16_11040	COG3409	Peptidoglycan-binding domain 1 protein
BW16_11045	COG2339	peptidase activity
BW16_11050	COG0492	ferredoxin-NADP+ reductase activity
BW16_11055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW16_11060	COG4862	establishment of competence for transformation
BW16_11065	COG1408	metallophosphoesterase
BW16_11075	COG1388	LysM domain
BW16_11080	COG1266	CAAX protease self-immunity
BW16_11085	COG0514	ATP-dependent DNA helicase (RecQ)
BW16_11090	COG4955	Helix-turn-helix domain
BW16_11095	COG1141	Ferredoxin
BW16_11100	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BW16_11105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BW16_11120	COG1595	DNA-templated transcription, initiation
BW16_11125	COG5002	protein histidine kinase activity
BW16_11130	COG0745	RESPONSE REGULATOR receiver
BW16_11135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW16_11140	COG1333	cytochrome c biogenesis protein
BW16_11145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_11150	COG1187	pseudouridine synthase activity
BW16_11155	COG0700	Nucleoside recognition
BW16_11160	COG2715	membrane protein required for spore maturation
BW16_11165	COG1686	Belongs to the peptidase S11 family
BW16_11175	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BW16_11180	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BW16_11190	COG1547	Domain of unknown function (DUF309)
BW16_11195	COG0456	acetyltransferase
BW16_11210	COG0307	riboflavin synthase, alpha
BW16_11230	COG2814	Major facilitator Superfamily
BW16_11235	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BW16_11240	COG4086	secreted protein
BW16_11245	COG0019	diaminopimelate decarboxylase activity
BW16_11250	COG0697	spore germination
BW16_11265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BW16_11285	COG1191	sigma factor activity
BW16_11290	COG2172	sigma factor antagonist activity
BW16_11300	COG1686	Belongs to the peptidase S11 family
BW16_11305	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BW16_11310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BW16_11315	COG4974	Belongs to the 'phage' integrase family
BW16_11325	COG0735	belongs to the Fur family
BW16_11330	COG1300	Membrane
BW16_11335	COG1404	Belongs to the peptidase S8 family
BW16_11345	COG2153	protein acetylation
BW16_11350	COG1379	DNA repair
BW16_11355	COG0494	nUDIX hydrolase
BW16_11360	COG0667	Aldo Keto reductase
BW16_11370	COG1073	alpha beta
BW16_11375	COG0457	Tetratricopeptide repeat
BW16_11385	COG4918	Iron-sulphur cluster biosynthesis
BW16_11390	COG4305	rare lipoprotein A
BW16_11395	COG0456	acetyltransferase
BW16_11395	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
BW16_11400	COG0456	acetyltransferase
BW16_11410	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW16_11420	COG2211	Major facilitator Superfamily
BW16_11425	COG2801	Transposase and inactivated derivatives
BW16_11435	COG1072	(Pantothenic acid kinase))
BW16_11440	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW16_11450	COG0300	oxidoreductase activity
BW16_11455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_11465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_11475	COG4187	Peptidase family M20/M25/M40
BW16_11480	COG1902	pentaerythritol trinitrate reductase activity
BW16_11485	COG0596	Alpha beta hydrolase
BW16_11490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW16_11500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BW16_11505	COG2188	Transcriptional regulator
BW16_11510	COG2723	6-phospho-beta-galactosidase activity
BW16_11515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_11520	COG1447	Phosphotransferase system cellobiose-specific component IIA
BW16_11525	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_11530	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_11540	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BW16_11545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BW16_11555	COG0706	membrane insertase activity
BW16_11560	COG0835	chemotaxis
BW16_11565	COG2195	Cleaves the N-terminal amino acid of tripeptides
BW16_11570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BW16_11585	COG1376	ErfK ybiS ycfS ynhG family protein
BW16_11590	COG4129	membrane
BW16_11595	COG1126	abc transporter atp-binding protein
BW16_11600	COG0765	amino acid transport
BW16_11605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_11615	COG1597	lipid kinase activity
BW16_11625	COG0508	dehydrogenase complex catalyzes the overall conversion of
BW16_11630	COG0022	dehydrogenase e1 component
BW16_11635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BW16_11640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW16_11645	COG3426	butyrate kinase activity
BW16_11650	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW16_11655	COG0280	phosphate acetyltransferase
BW16_11660	COG3829	transcription factor binding
BW16_11660	COG3290	protein histidine kinase activity
BW16_11670	COG0584	glycerophosphoryl diester phosphodiesterase
BW16_11680	COG0457	Tetratricopeptide repeat
BW16_11685	COG0745	RESPONSE REGULATOR receiver
BW16_11690	COG0750	zinc metalloprotease
BW16_11695	COG0497	DNA recombination
BW16_11700	COG1438	arginine binding
BW16_11705	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BW16_11710	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW16_11715	COG0142	geranyltranstransferase activity
BW16_11720	COG1722	exodeoxyribonuclease VII activity
BW16_11725	COG1570	exodeoxyribonuclease VII activity
BW16_11730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BW16_11735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW16_11740	COG1302	Protein conserved in bacteria
BW16_11745	COG0439	Biotin carboxylase
BW16_11750	COG0511	ligase activity, forming carbon-carbon bonds
BW16_11790	COG3854	ATPases associated with a variety of cellular activities
BW16_11800	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BW16_11805	COG0006	proline dipeptidase activity
BW16_11810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BW16_11820	COG3872	metal-dependent enzyme
BW16_11830	COG1752	Esterase of the alpha-beta hydrolase superfamily
BW16_11835	COG1321	iron dependent repressor
BW16_11840	COG0095	Lipoate-protein ligase
BW16_11845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_11850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW16_11855	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW16_11860	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BW16_11865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW16_11890	COG0681	Belongs to the peptidase S26 family
BW16_11925	COG4970	Tfp pilus assembly protein FimT
BW16_11930	COG4537	Required for transformation and DNA binding
BW16_11935	COG1459	type II secretion system
BW16_11940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BW16_11950	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_11960	COG1393	Belongs to the ArsC family
BW16_11970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_11980	COG0011	TIGRFAM Protein of
BW16_11985	COG2814	Major facilitator Superfamily
BW16_11990	COG2866	Carboxypeptidase
BW16_11995	COG1368	sulfuric ester hydrolase activity
BW16_12000	COG1940	carbohydrate kinase activity
BW16_12005	COG4483	Protein conserved in bacteria
BW16_12010	COG0705	Rhomboid family
BW16_12010	COG0457	Tetratricopeptide repeat
BW16_12025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BW16_12030	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW16_12045	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BW16_12050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW16_12055	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW16_12060	COG0581	inorganic phosphate transmembrane transporter activity
BW16_12065	COG0573	inorganic phosphate transmembrane transporter activity
BW16_12070	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BW16_12080	COG0477	Major facilitator Superfamily
BW16_12085	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BW16_12090	COG2839	Protein conserved in bacteria
BW16_12095	COG5521	maltodextrose utilization protein MalA
BW16_12100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW16_12105	COG1388	LysM domain
BW16_12110	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BW16_12115	COG4709	membrane
BW16_12120	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BW16_12125	COG1940	carbohydrate kinase activity
BW16_12135	COG0735	belongs to the Fur family
BW16_12140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW16_12145	COG1121	(ABC) transporter
BW16_12150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_12165	COG0513	Belongs to the DEAD box helicase family
BW16_12175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BW16_12180	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BW16_12185	COG2384	SAM-dependent methyltransferase
BW16_12190	COG2010	Cytochrome c
BW16_12195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW16_12200	COG0358	DNA primase activity
BW16_12205	COG1671	Belongs to the UPF0178 family
BW16_12210	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BW16_12215	COG0517	IMP dehydrogenase activity
BW16_12220	COG0751	glycine-tRNA ligase activity
BW16_12225	COG0752	glycyl-tRNA synthetase alpha subunit
BW16_12230	COG1381	Involved in DNA repair and RecF pathway recombination
BW16_12240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW16_12245	COG0295	cytidine deaminase activity
BW16_12250	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BW16_12255	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BW16_12260	COG1480	7TM receptor with intracellular HD hydrolase
BW16_12265	COG1702	phosphate starvation-inducible protein PhoH
BW16_12270	COG0561	phosphatase activity
BW16_12285	COG4864	UPF0365 protein
BW16_12290	COG1030	water channel activity
BW16_12295	COG1610	YqeY-like protein
BW16_12300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BW16_12305	COG1283	sodium-dependent phosphate transmembrane transporter activity
BW16_12310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW16_12315	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BW16_12320	COG2264	protein methyltransferase activity
BW16_12325	COG0484	heat shock protein binding
BW16_12330	COG0443	Heat shock 70 kDa protein
BW16_12335	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW16_12340	COG1420	regulation of RNA biosynthetic process
BW16_12345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BW16_12350	COG0481	GTPase activity
BW16_12360	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_12365	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BW16_12370	COG0268	Binds directly to 16S ribosomal RNA
BW16_12375	COG1466	dna polymerase III delta subunit
BW16_12385	COG2333	competence protein COMEC
BW16_12385	COG0658	competence protein
BW16_12390	COG2131	deaminase
BW16_12395	COG1555	photosystem II stabilization
BW16_12395	COG1596	polysaccharide export
BW16_12400	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BW16_12405	COG2226	methyltransferase
BW16_12410	COG0799	negative regulation of ribosome biogenesis
BW16_12415	COG1713	HD superfamily hydrolase involved in NAD metabolism
BW16_12420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BW16_12425	COG1534	Rna-binding protein
BW16_12430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW16_12435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BW16_12440	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BW16_12455	COG2755	lipolytic protein G-D-S-L family
BW16_12465	COG0457	Tetratricopeptide repeat
BW16_12490	COG2186	Transcriptional regulator
BW16_12505	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_12510	COG3958	Transketolase
BW16_12515	COG3959	Transketolase, thiamine diphosphate binding domain
BW16_12545	COG0726	polysaccharide deacetylase
BW16_12580	COG1122	ATPase activity
BW16_12610	COG2160	L-arabinose isomerase activity
BW16_12625	COG1609	Transcriptional regulator
BW16_12645	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BW16_12650	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BW16_12655	COG1733	regulation of RNA biosynthetic process
BW16_12720	COG2602	Beta-lactamase
BW16_12725	COG1960	acyl-CoA dehydrogenase activity
BW16_12730	COG1126	abc transporter atp-binding protein
BW16_12735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_12740	COG0765	amino acid transport
BW16_12750	COG3546	catalase activity
BW16_12755	COG1063	alcohol dehydrogenase
BW16_12770	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_12780	COG1115	amino acid carrier protein
BW16_12785	COG0583	DNA-binding transcription factor activity
BW16_12790	COG1063	alcohol dehydrogenase
BW16_12795	COG2226	methyltransferase
BW16_12815	COG0626	cystathionine gamma-synthase activity
BW16_12820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_12830	COG2226	methyltransferase
BW16_12845	COG0768	penicillin binding
BW16_12850	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BW16_12855	COG0572	uridine kinase
BW16_12875	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BW16_12880	COG0183	Belongs to the thiolase family
BW16_12885	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_12890	COG1268	BioY protein
BW16_12895	COG3906	Belongs to the UPF0473 family
BW16_12900	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BW16_12905	COG4472	Bacterial protein of unknown function (DUF965)
BW16_12910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW16_12915	COG0628	permease
BW16_12920	COG1126	abc transporter atp-binding protein
BW16_12925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_12930	COG0765	amino acid transport
BW16_12935	COG0765	amino acid transport
BW16_12950	COG3881	PFAM PRC-barrel domain
BW16_12955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BW16_12960	COG0457	Tetratricopeptide repeat
BW16_12965	COG0482	sulfurtransferase activity
BW16_12970	COG1104	cysteine desulfurase activity
BW16_12975	COG1959	2 iron, 2 sulfur cluster binding
BW16_12980	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BW16_12985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BW16_12995	COG0124	histidyl-tRNA synthetase
BW16_13005	COG3103	Sh3 type 3 domain protein
BW16_13005	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_13005	COG4991	sh3 domain protein
BW16_13010	COG1490	D-aminoacyl-tRNA deacylase activity
BW16_13015	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BW16_13020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW16_13025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BW16_13025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BW16_13030	COG5416	Lipopolysaccharide assembly protein A domain
BW16_13035	COG0490	domain, Protein
BW16_13040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW16_13040	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW16_13050	COG2244	polysaccharide biosynthetic process
BW16_13055	COG2323	membrane
BW16_13065	COG1862	Preprotein translocase
BW16_13070	COG0343	queuine tRNA-ribosyltransferase activity
BW16_13075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BW16_13085	COG2255	four-way junction helicase activity
BW16_13090	COG0632	four-way junction helicase activity
BW16_13100	COG2112	serine threonine protein kinase
BW16_13115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BW16_13130	COG1388	LysM domain
BW16_13135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BW16_13140	COG0157	Belongs to the NadC ModD family
BW16_13145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BW16_13150	COG1104	cysteine desulfurase activity
BW16_13155	COG1827	regulation of RNA biosynthetic process
BW16_13160	COG0077	Prephenate dehydratase
BW16_13165	COG4492	Belongs to the UPF0735 family
BW16_13170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW16_13175	COG3290	protein histidine kinase activity
BW16_13180	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BW16_13185	COG2868	ribosomal protein
BW16_13190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BW16_13195	COG1994	Peptidase M50
BW16_13200	COG0739	heme binding
BW16_13205	COG2894	cell division
BW16_13210	COG0850	regulation of cytokinetic process
BW16_13215	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BW16_13220	COG1792	Involved in formation and maintenance of cell shape
BW16_13225	COG1077	Cell shape determining protein MreB Mrl
BW16_13230	COG2003	Belongs to the UPF0758 family
BW16_13235	COG0424	maF-like protein
BW16_13250	COG0285	dihydrofolate synthase activity
BW16_13255	COG0525	valine-tRNA ligase activity
BW16_13265	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BW16_13270	COG1388	LysM domain
BW16_13275	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW16_13280	COG0113	porphobilinogen synthase activity
BW16_13285	COG1587	Uroporphyrinogen-III synthase
BW16_13290	COG0181	hydroxymethylbilane synthase activity
BW16_13295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BW16_13300	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW16_13310	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BW16_13315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BW16_13320	COG1067	ATP-dependent peptidase activity
BW16_13320	COG0470	DNA polymerase III
BW16_13325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BW16_13330	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW16_13335	COG0457	Tetratricopeptide repeat
BW16_13335	COG1477	protein flavinylation
BW16_13340	COG0066	3-isopropylmalate dehydratase activity
BW16_13345	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BW16_13350	COG0473	3-isopropylmalate dehydrogenase activity
BW16_13355	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BW16_13360	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BW16_13365	COG0440	acetolactate synthase activity
BW16_13370	COG0028	Belongs to the TPP enzyme family
BW16_13375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_13385	COG2706	6-phosphogluconolactonase activity
BW16_13390	COG3339	Conserved Protein
BW16_13395	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
BW16_13400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW16_13405	COG1696	Membrane protein involved in D-alanine export
BW16_13410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BW16_13420	COG5444	nuclease activity
BW16_13445	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
BW16_13450	COG5444	nuclease activity
BW16_13465	COG0622	Phosphoesterase
BW16_13470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BW16_13475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BW16_13480	COG5401	PFAM Sporulation and spore germination
BW16_13485	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BW16_13490	COG1846	Transcriptional regulator
BW16_13495	COG2197	response regulator
BW16_13500	COG2851	Citrate transporter
BW16_13505	COG0583	DNA-binding transcription factor activity
BW16_13510	COG2828	Protein conserved in bacteria
BW16_13520	COG0824	Thioesterase
BW16_13525	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BW16_13530	COG1053	succinate dehydrogenase
BW16_13535	COG2009	succinate dehydrogenase
BW16_13540	COG1719	4-vinyl reductase, 4VR
BW16_13545	COG0527	aspartate kinase activity
BW16_13550	COG0322	excinuclease ABC activity
BW16_13560	COG3118	belongs to the thioredoxin family
BW16_13565	COG3534	alpha-L-arabinofuranosidase
BW16_13575	COG2086	electron transfer activity
BW16_13580	COG1024	Enoyl-CoA hydratase
BW16_13585	COG1309	transcriptional regulator
BW16_13590	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_13600	COG3766	membrane
BW16_13610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW16_13610	COG1796	DNA polymerase
BW16_13615	COG1286	toxin biosynthetic process
BW16_13620	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BW16_13625	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW16_13630	COG0072	phenylalanine-tRNA ligase activity
BW16_13630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_13635	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BW16_13640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW16_13650	COG1966	Carbon starvation protein
BW16_13655	COG1363	Peptidase, m42
BW16_13665	COG3326	Membrane
BW16_13670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BW16_13675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BW16_13680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BW16_13705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW16_13715	COG0398	Pfam SNARE associated Golgi protein
BW16_13720	COG1484	DNA-dependent DNA replication
BW16_13725	COG3611	Membrane attachment protein
BW16_13730	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW16_13740	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BW16_13745	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW16_13750	COG0237	dephospho-CoA kinase activity
BW16_13755	COG1971	Probably functions as a manganese efflux pump
BW16_13760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BW16_13765	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW16_13765	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW16_13770	COG5002	protein histidine kinase activity
BW16_13775	COG0745	RESPONSE REGULATOR receiver
BW16_13780	COG0039	L-malate dehydrogenase activity
BW16_13785	COG0538	isocitrate dehydrogenase activity
BW16_13790	COG0372	Belongs to the citrate synthase family
BW16_13795	COG2707	UPF0756 membrane protein
BW16_13800	COG0628	permease
BW16_13805	COG3030	protein affecting phage T7 exclusion by the F plasmid
BW16_13815	COG0205	6-phosphofructokinase activity
BW16_13820	COG0825	malonyl-CoA metabolic process
BW16_13825	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BW16_13830	COG0281	malic enzyme
BW16_13835	COG0587	DNA-directed DNA polymerase activity
BW16_13855	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BW16_13870	COG4109	DRTGG domain
BW16_13875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BW16_13880	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_13890	COG0165	Argininosuccinate lyase
BW16_13895	COG0137	argininosuccinate synthase activity
BW16_13900	COG0521	Mo-molybdopterin cofactor biosynthetic process
BW16_13905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BW16_13910	COG0827	DNA restriction-modification system
BW16_13915	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BW16_13920	COG3874	Sporulation protein YtfJ
BW16_13930	COG1714	RDD family
BW16_13935	COG0616	signal peptide processing
BW16_13940	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW16_13955	COG3239	Fatty acid desaturase
BW16_13965	COG4585	Histidine kinase
BW16_13970	COG2197	response regulator
BW16_13975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_13980	COG0745	RESPONSE REGULATOR receiver
BW16_13985	COG2205	protein histidine kinase activity
BW16_13990	COG1136	(ABC) transporter
BW16_13995	COG0577	efflux transmembrane transporter activity
BW16_14000	COG0402	S-adenosylhomocysteine deaminase activity
BW16_14005	COG2249	NAD(P)H dehydrogenase (quinone) activity
BW16_14025	COG1279	arginine transmembrane transporter activity
BW16_14030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW16_14040	COG0301	tRNA thio-modification
BW16_14045	COG1104	cysteine desulfurase activity
BW16_14050	COG1114	Component of the transport system for branched-chain amino acids
BW16_14055	COG1114	Component of the transport system for branched-chain amino acids
BW16_14060	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BW16_14065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW16_14070	COG1309	transcriptional regulator
BW16_14075	COG1956	GAF domain-containing protein
BW16_14080	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BW16_14090	COG1335	isochorismatase
BW16_14105	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
BW16_14110	COG2329	Antibiotic biosynthesis monooxygenase
BW16_14115	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BW16_14120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BW16_14125	COG0454	-acetyltransferase
BW16_14130	COG0517	IMP dehydrogenase activity
BW16_14135	COG0123	including yeast histone deacetylase and acetoin utilization protein
BW16_14140	COG1609	Transcriptional regulator
BW16_14150	COG2801	Transposase and inactivated derivatives
BW16_14155	COG1605	Chorismate mutase
BW16_14155	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BW16_14160	COG3118	belongs to the thioredoxin family
BW16_14165	COG4980	gas vesicle protein
BW16_14170	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
BW16_14175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BW16_14180	COG1674	ftsk spoiiie
BW16_14185	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW16_14190	COG4848	Belongs to the UPF0354 family
BW16_14195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_14210	COG1363	Peptidase, m42
BW16_14215	COG5584	Small secreted protein
BW16_14220	COG0281	malic enzyme
BW16_14225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_14230	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BW16_14240	COG0510	thiamine kinase activity
BW16_14245	COG1597	lipid kinase activity
BW16_14255	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BW16_14260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW16_14265	COG3340	Belongs to the peptidase S51 family
BW16_14270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW16_14275	COG2252	PERMEase
BW16_14280	COG1349	DNA-binding transcription factor activity
BW16_14285	COG1187	pseudouridine synthase activity
BW16_14290	COG2244	polysaccharide biosynthetic process
BW16_14295	COG2081	HI0933 family
BW16_14305	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BW16_14310	COG3196	Protein conserved in bacteria
BW16_14320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BW16_14325	COG5578	integral membrane protein
BW16_14330	COG0673	inositol 2-dehydrogenase activity
BW16_14335	COG1653	transport
BW16_14340	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
BW16_14345	COG4209	transmembrane transport
BW16_14350	COG2207	Transcriptional regulator
BW16_14355	COG1733	regulation of RNA biosynthetic process
BW16_14360	COG2814	Major facilitator Superfamily
BW16_14365	COG0656	L-ascorbic acid biosynthetic process
BW16_14370	COG1653	transport
BW16_14375	COG0395	ABC-type sugar transport system, permease component
BW16_14380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW16_14385	COG1073	alpha beta
BW16_14390	COG0495	leucyl-tRNA aminoacylation
BW16_14405	COG2202	Pas domain
BW16_14405	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_14410	COG2433	Pfam Transposase IS66
BW16_14415	COG0577	efflux transmembrane transporter activity
BW16_14420	COG1136	(ABC) transporter
BW16_14430	COG1131	(ABC) transporter
BW16_14435	COG1725	Transcriptional regulator
BW16_14455	COG1242	4 iron, 4 sulfur cluster binding
BW16_14460	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BW16_14465	COG4326	sporulation control protein
BW16_14475	COG2267	carboxylic ester hydrolase activity
BW16_14480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BW16_14485	COG0367	asparagine synthase
BW16_14490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BW16_14495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BW16_14505	COG1506	peptidase
BW16_14510	COG1233	COG1233 Phytoene dehydrogenase and related
BW16_14530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BW16_14535	COG1116	anion transmembrane transporter activity
BW16_14540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BW16_14545	COG0494	nUDIX hydrolase
BW16_14550	COG2310	stress, protein
BW16_14565	COG4824	toxin secretion phage lysis holin
BW16_14575	COG0783	Belongs to the Dps family
BW16_14590	COG1854	S-ribosylhomocysteine lyase activity
BW16_14595	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BW16_14600	COG0288	reversible hydration of carbon dioxide
BW16_14605	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW16_14605	COG3443	Belongs to the bacterial solute-binding protein 9 family
BW16_14615	COG1271	oxidase subunit
BW16_14620	COG1294	oxidase, subunit
BW16_14635	COG4948	Mandelate Racemase Muconate Lactonizing
BW16_14640	COG0318	PFAM AMP-dependent synthetase and ligase
BW16_14645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BW16_14650	COG0596	Alpha beta hydrolase
BW16_14655	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BW16_14660	COG1169	isochorismate synthase
BW16_14665	COG1575	Belongs to the MenA family. Type 1 subfamily
BW16_14670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BW16_14800	COG3859	Proton-coupled thiamine transporter YuaJ
BW16_14805	COG1247	-acetyltransferase
BW16_14810	COG3339	Conserved Protein
BW16_14815	COG0772	Belongs to the SEDS family
BW16_14820	COG0772	Belongs to the SEDS family
BW16_14825	COG2268	Band 7 protein
BW16_14830	COG1585	Membrane protein implicated in regulation of membrane protease activity
BW16_14835	COG2318	DinB family
BW16_14840	COG1454	alcohol dehydrogenase
BW16_14850	COG1510	regulation of RNA biosynthetic process
BW16_14865	COG3409	Peptidoglycan-binding domain 1 protein
BW16_14865	COG5632	N-Acetylmuramoyl-L-alanine amidase
BW16_14935	COG3778	Protein conserved in bacteria
BW16_14940	COG3299	homolog of phage Mu protein gp47
BW16_14945	COG3628	GPW Gp25 family protein
BW16_14955	COG4193	domain, Protein
BW16_14960	COG1652	LysM domain
BW16_14965	COG5280	Phage tail tape measure protein TP901
BW16_14965	COG3953	SLT domain
BW16_15020	COG4653	Phage capsid family
BW16_15025	COG0338	D12 class N6 adenine-specific DNA methyltransferase
BW16_15035	COG1783	phage Terminase large subunit
BW16_15040	COG5484	DNA packaging
BW16_15045	COG1595	DNA-templated transcription, initiation
BW16_15055	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
BW16_15080	COG1396	sequence-specific DNA binding
BW16_15090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BW16_15105	COG0628	permease
BW16_15115	COG0673	inositol 2-dehydrogenase activity
BW16_15120	COG0693	protein deglycase activity
BW16_15125	COG0840	transmembrane signaling receptor activity
BW16_15130	COG0840	transmembrane signaling receptor activity
BW16_15135	COG0840	transmembrane signaling receptor activity
BW16_15140	COG0840	transmembrane signaling receptor activity
BW16_15155	COG2070	2-Nitropropane dioxygenase
BW16_15160	COG0432	Pfam Uncharacterised protein family UPF0047
BW16_15165	COG1253	flavin adenine dinucleotide binding
BW16_15170	COG2738	Putative neutral zinc metallopeptidase
BW16_15180	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BW16_15205	COG1979	alcohol dehydrogenase
BW16_15210	COG1979	alcohol dehydrogenase
BW16_15215	COG2155	Conserved Protein
BW16_15220	COG1098	S1 RNA binding domain
BW16_15225	COG0436	Aminotransferase
BW16_15230	COG1522	sequence-specific DNA binding
BW16_15235	COG2267	carboxylic ester hydrolase activity
BW16_15245	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW16_15250	COG2205	protein histidine kinase activity
BW16_15265	COG5018	Exonuclease
BW16_15270	COG2814	Major facilitator Superfamily
BW16_15275	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_15280	COG3011	Protein conserved in bacteria
BW16_15290	COG3290	protein histidine kinase activity
BW16_15295	COG4565	transcriptional regulatory protein
BW16_15320	COG3493	citrate carrier protein
BW16_15330	COG2111	Na H antiporter
BW16_15330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BW16_15335	COG2111	Na H antiporter
BW16_15340	COG1006	Multisubunit Na H antiporter MnhC subunit
BW16_15345	COG0651	ATP synthesis coupled electron transport
BW16_15350	COG1863	multisubunit Na H antiporter MnhE subunit
BW16_15355	COG2212	antiporter activity
BW16_15360	COG1320	monovalent cation:proton antiporter activity
BW16_15365	COG2050	protein possibly involved in aromatic compounds catabolism
BW16_15370	COG2197	response regulator
BW16_15375	COG4585	Histidine kinase
BW16_15385	COG0142	geranyltranstransferase activity
BW16_15400	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
BW16_15405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BW16_15410	COG1335	isochorismatase
BW16_15415	COG5506	Protein of unknown function (DUF1694)
BW16_15435	COG0628	permease
BW16_15450	COG1418	mRNA catabolic process
BW16_15455	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_15465	COG1511	domain protein
BW16_15470	COG1674	ftsk spoiiie
BW16_15470	COG0433	COG0433 Predicted ATPase
BW16_15475	COG4499	WXG100 protein secretion system (Wss), protein YukC
BW16_15480	COG5417	Belongs to the EsaB family
BW16_15485	COG4842	Belongs to the WXG100 family
BW16_15490	COG2508	Transcriptional regulator
BW16_15490	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BW16_15495	COG0686	Belongs to the AlaDH PNT family
BW16_15500	COG1268	BioY protein
BW16_15505	COG2056	Na+-H+ antiporter family
BW16_15510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BW16_15515	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
BW16_15520	COG3584	3D domain protein
BW16_15535	COG1252	NADH dehydrogenase
BW16_15540	COG0492	ferredoxin-NADP+ reductase activity
BW16_15560	COG0316	Belongs to the HesB IscA family
BW16_15565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BW16_15570	COG4844	belongs to the
BW16_15575	COG1252	NADH dehydrogenase
BW16_15585	COG4837	Protein of unknown function (DUF1462)
BW16_15590	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BW16_15595	COG0823	Involved in the tonB-independent uptake of proteins
BW16_15595	COG1506	peptidase
BW16_15595	COG4946	Tricorn protease homolog
BW16_15600	COG0083	homoserine kinase activity
BW16_15605	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW16_15610	COG0460	homoserine dehydrogenase
BW16_15615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW16_15620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BW16_15625	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BW16_15630	COG0647	UMP catabolic process
BW16_15635	COG2445	Protein of unknown function DUF86
BW16_15640	COG4470	Protein conserved in bacteria
BW16_15650	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BW16_15655	COG0739	heme binding
BW16_15675	COG3377	Domain of unknown function (DUF1805)
BW16_15680	COG0737	Belongs to the 5'-nucleotidase family
BW16_15685	COG1801	Protein of unknown function DUF72
BW16_15690	COG2508	Transcriptional regulator
BW16_15695	COG2140	Oxalate decarboxylase
BW16_15700	COG2814	Major facilitator Superfamily
BW16_15705	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BW16_15710	COG2356	endonuclease I
BW16_15725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_15730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_15735	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_15750	COG0561	phosphatase activity
BW16_15760	COG5002	protein histidine kinase activity
BW16_15760	COG0642	Histidine kinase
BW16_15765	COG0745	RESPONSE REGULATOR receiver
BW16_15770	COG2311	Membrane
BW16_15780	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BW16_15785	COG1090	epimerase
BW16_15805	COG0719	Fe-S assembly protein
BW16_15810	COG0822	iron-sulfur transferase activity
BW16_15815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BW16_15820	COG0719	Fe-S assembly protein
BW16_15825	COG0396	ATPase activity
BW16_15835	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BW16_15840	COG1464	Belongs to the NlpA lipoprotein family
BW16_15845	COG2011	ABC-type metal ion transport system permease component
BW16_15850	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BW16_15860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BW16_15865	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BW16_15875	COG0509	glycine decarboxylation via glycine cleavage system
BW16_15880	COG1393	Belongs to the ArsC family
BW16_15885	COG1960	acyl-CoA dehydrogenase activity
BW16_15890	COG0183	Belongs to the thiolase family
BW16_15895	COG1024	Enoyl-CoA hydratase
BW16_15895	COG1250	3-hydroxyacyl-CoA dehydrogenase
BW16_15910	COG5577	PFAM Coat F domain
BW16_15920	COG1120	ATPase activity
BW16_15930	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_15935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_15940	COG0745	RESPONSE REGULATOR receiver
BW16_15945	COG2770	Histidine kinase
BW16_15945	COG2205	protein histidine kinase activity
BW16_15955	COG1309	transcriptional regulator
BW16_15965	COG0114	fumarate hydratase activity
BW16_15975	COG0697	spore germination
BW16_15980	COG0814	amino acid
BW16_15995	COG2197	response regulator
BW16_16000	COG4585	Histidine kinase
BW16_16005	COG4758	membrane
BW16_16015	COG1842	Phage shock protein A
BW16_16020	COG4758	membrane
BW16_16025	COG2096	Adenosyltransferase
BW16_16030	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_16035	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BW16_16045	COG3604	Transcriptional regulator
BW16_16060	COG1454	alcohol dehydrogenase
BW16_16065	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW16_16070	COG1120	ATPase activity
BW16_16075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_16080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_16090	COG2721	sulfolactate sulfo-lyase activity
BW16_16095	COG0246	Mannitol dehydrogenase
BW16_16100	COG1609	Transcriptional regulator
BW16_16105	COG1904	glucuronate isomerase
BW16_16110	COG2205	protein histidine kinase activity
BW16_16115	COG0745	RESPONSE REGULATOR receiver
BW16_16120	COG1120	ATPase activity
BW16_16125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_16130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_16135	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_16140	COG0531	amino acid
BW16_16155	COG1988	membrane-bound metal-dependent
BW16_16160	COG1368	sulfuric ester hydrolase activity
BW16_16165	COG0725	ABC transporter, periplasmic molybdate-binding protein
BW16_16170	COG4149	molybdate abc transporter
BW16_16175	COG0656	L-ascorbic acid biosynthetic process
BW16_16180	COG1940	carbohydrate kinase activity
BW16_16185	COG0025	NhaP-type Na H and K H
BW16_16190	COG2860	membrane
BW16_16195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BW16_16200	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BW16_16205	COG2217	Heavy metal translocating P-type atpase
BW16_16210	COG1121	(ABC) transporter
BW16_16215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW16_16220	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW16_16230	COG3226	Transcriptional regulator
BW16_16235	COG0784	Response regulator, receiver
BW16_16240	COG4191	Histidine kinase
BW16_16245	COG1027	Aspartate ammonia-lyase
BW16_16260	COG2217	Heavy metal translocating P-type atpase
BW16_16265	COG2608	mercury ion transmembrane transporter activity
BW16_16270	COG1937	Protein conserved in bacteria
BW16_16280	COG3706	GGDEF domain
BW16_16280	COG0745	RESPONSE REGULATOR receiver
BW16_16290	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_16290	COG0463	Glycosyl transferase, family 2
BW16_16295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BW16_16300	COG0557	exoribonuclease II activity
BW16_16305	COG1647	Serine aminopeptidase, S33
BW16_16310	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW16_16315	COG2002	toxin-antitoxin pair type II binding
BW16_16320	COG1476	TRANSCRIPTIONal
BW16_16325	COG1396	sequence-specific DNA binding
BW16_16330	COG1396	sequence-specific DNA binding
BW16_16335	COG1733	regulation of RNA biosynthetic process
BW16_16340	COG1174	glycine betaine transport
BW16_16345	COG1732	Glycine betaine
BW16_16350	COG1174	glycine betaine transport
BW16_16355	COG0517	IMP dehydrogenase activity
BW16_16355	COG1125	glycine betaine transport
BW16_16360	COG1510	regulation of RNA biosynthetic process
BW16_16365	COG2095	MarC family integral membrane protein
BW16_16375	COG0456	acetyltransferase
BW16_16395	COG1131	(ABC) transporter
BW16_16405	COG0148	phosphopyruvate hydratase activity
BW16_16410	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BW16_16415	COG0149	triose-phosphate isomerase activity
BW16_16420	COG0126	phosphoglycerate kinase activity
BW16_16425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW16_16430	COG2390	Transcriptional regulator
BW16_16435	COG0833	amino acid
BW16_16440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW16_16445	COG3829	transcription factor binding
BW16_16450	COG2186	Transcriptional regulator
BW16_16460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BW16_16470	COG0534	Mate efflux family protein
BW16_16475	COG4608	Belongs to the ABC transporter superfamily
BW16_16480	COG0444	Belongs to the ABC transporter superfamily
BW16_16485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW16_16490	COG0601	transmembrane transport
BW16_16495	COG0747	negative chemotaxis
BW16_16500	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW16_16505	COG0110	maltose O-acetyltransferase activity
BW16_16510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BW16_16515	COG2244	polysaccharide biosynthetic process
BW16_16520	COG5039	Polysaccharide pyruvyl transferase
BW16_16525	COG1216	Glycosyl transferase, family 2
BW16_16535	COG0438	transferase activity, transferring glycosyl groups
BW16_16540	COG1215	transferase activity, transferring glycosyl groups
BW16_16550	COG1086	Polysaccharide biosynthesis protein
BW16_16555	COG0489	protein tyrosine kinase activity
BW16_16560	COG3944	biosynthesis protein
BW16_16565	COG1396	sequence-specific DNA binding
BW16_16575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_16580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_16585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_16590	COG0726	polysaccharide deacetylase
BW16_16600	COG4608	Belongs to the ABC transporter superfamily
BW16_16615	COG0601	transmembrane transport
BW16_16620	COG0747	negative chemotaxis
BW16_16625	COG1819	glycosyl
BW16_16630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_16645	COG0740	serine-type endopeptidase activity
BW16_16650	COG1611	Belongs to the LOG family
BW16_16655	COG1694	Mazg nucleotide pyrophosphohydrolase
BW16_16660	COG0659	secondary active sulfate transmembrane transporter activity
BW16_16665	COG0288	reversible hydration of carbon dioxide
BW16_16675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW16_16685	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BW16_16690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_16695	COG1481	regulation of sporulation
BW16_16700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BW16_16705	COG1660	Displays ATPase and GTPase activities
BW16_16710	COG1051	belongs to the nudix hydrolase family
BW16_16715	COG0492	ferredoxin-NADP+ reductase activity
BW16_16720	COG3883	PFAM NLP P60 protein
BW16_16720	COG0791	NLP P60 protein
BW16_16725	COG0457	Tetratricopeptide repeat
BW16_16730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BW16_16730	COG0140	phosphoribosyl-ATP diphosphatase activity
BW16_16735	COG0107	imidazoleglycerol-phosphate synthase activity
BW16_16740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BW16_16745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BW16_16750	COG0131	Imidazoleglycerol-phosphate dehydratase
BW16_16755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BW16_16760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BW16_16765	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BW16_16770	COG4990	cell redox homeostasis
BW16_16775	COG2910	NAD(P)H-binding
BW16_16780	COG1959	2 iron, 2 sulfur cluster binding
BW16_16785	COG0110	maltose O-acetyltransferase activity
BW16_16790	COG0546	phosphoglycolate phosphatase activity
BW16_16795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BW16_16805	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BW16_16810	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BW16_16815	COG0363	glucosamine-6-phosphate deaminase activity
BW16_16825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BW16_16830	COG1950	PFAM Membrane protein of
BW16_16835	COG1983	PspC domain protein
BW16_16840	COG3595	metallopeptidase activity
BW16_16855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW16_16870	COG4897	Protein conserved in bacteria
BW16_16875	COG3848	Pyruvate phosphate dikinase
BW16_16875	COG0574	Belongs to the PEP-utilizing enzyme family
BW16_16880	COG1309	transcriptional regulator
BW16_16885	COG2814	Major facilitator Superfamily
BW16_16895	COG0745	RESPONSE REGULATOR receiver
BW16_16900	COG5002	protein histidine kinase activity
BW16_16905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BW16_16910	COG0463	Glycosyl transferase, family 2
BW16_16915	COG1113	amino acid transport
BW16_16920	COG0778	Nitroreductase
BW16_16925	COG1733	regulation of RNA biosynthetic process
BW16_16930	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_16940	COG0793	Belongs to the peptidase S41A family
BW16_16940	COG3409	Peptidoglycan-binding domain 1 protein
BW16_16945	COG0730	response to heat
BW16_16950	COG0791	NLP P60 protein
BW16_16950	COG3883	PFAM NLP P60 protein
BW16_16955	COG2177	Part of the ABC transporter FtsEX involved in
BW16_16960	COG2884	Cell division ATP-binding protein ftsE
BW16_16965	COG2010	Cytochrome c
BW16_16970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW16_16985	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW16_16990	COG0653	protein targeting
BW16_16995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BW16_17000	COG0840	transmembrane signaling receptor activity
BW16_17015	COG1516	flagellar protein fliS
BW16_17020	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BW16_17025	COG1334	flagellar protein FlaG
BW16_17030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BW16_17035	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BW16_17045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW16_17050	COG1256	bacterial-type flagellum assembly
BW16_17050	COG4786	Flagellar basal body rod
BW16_17055	COG3418	PFAM FlgN family protein
BW16_17070	COG1040	competence protein
BW16_17080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BW16_17085	COG1307	EDD domain protein, DegV family
BW16_17090	COG2197	response regulator
BW16_17095	COG4585	Histidine kinase
BW16_17100	COG1739	Uncharacterized protein family UPF0029
BW16_17105	COG1316	TRANSCRIPTIONal
BW16_17110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW16_17115	COG0438	transferase activity, transferring glycosyl groups
BW16_17120	COG1215	transferase activity, transferring glycosyl groups
BW16_17125	COG3206	protein involved in exopolysaccharide biosynthesis
BW16_17130	COG3307	-O-antigen
BW16_17135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW16_17140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW16_17145	COG0438	transferase activity, transferring glycosyl groups
BW16_17145	COG0297	glycogen (starch) synthase activity
BW16_17150	COG2244	polysaccharide biosynthetic process
BW16_17165	COG2247	cell wall binding repeat
BW16_17165	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_17170	COG2247	cell wall binding repeat
BW16_17170	COG0860	N-Acetylmuramoyl-L-alanine amidase
BW16_17175	COG2247	cell wall binding repeat
BW16_17175	COG2385	sporulation resulting in formation of a cellular spore
BW16_17185	COG1316	TRANSCRIPTIONal
BW16_17190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BW16_17195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BW16_17200	COG1134	teichoic acid transport
BW16_17205	COG1682	transport, permease protein
BW16_17210	COG1215	transferase activity, transferring glycosyl groups
BW16_17240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BW16_17245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
BW16_17250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_17255	COG4193	domain, Protein
BW16_17260	COG1482	cell wall glycoprotein biosynthetic process
BW16_17270	COG1175	transmembrane transport
BW16_17275	COG1653	transport
BW16_17280	COG2197	response regulator
BW16_17285	COG2972	Histidine kinase
BW16_17295	COG0454	-acetyltransferase
BW16_17300	COG0800	Aldolase
BW16_17305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW16_17310	COG1609	Transcriptional regulator
BW16_17315	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
BW16_17320	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_17325	COG0697	spore germination
BW16_17330	COG0814	amino acid
BW16_17345	COG2814	Major facilitator Superfamily
BW16_17350	COG1316	TRANSCRIPTIONal
BW16_17355	COG0561	phosphatase activity
BW16_17360	COG0791	NLP P60 protein
BW16_17370	COG2843	Capsule synthesis protein
BW16_17380	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW16_17385	COG0697	spore germination
BW16_17400	COG1609	Transcriptional regulator
BW16_17405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW16_17410	COG1869	D-ribose catabolic process
BW16_17415	COG1129	ABC transporter
BW16_17420	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW16_17425	COG1879	ABC-type sugar transport system periplasmic component
BW16_17430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BW16_17435	COG0583	DNA-binding transcription factor activity
BW16_17440	COG0028	Belongs to the TPP enzyme family
BW16_17445	COG3527	Alpha-acetolactate decarboxylase
BW16_17450	COG1522	sequence-specific DNA binding
BW16_17455	COG2059	Chromate
BW16_17460	COG2059	Chromate
BW16_17465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BW16_17475	COG4715	Zinc finger, swim domain protein
BW16_17480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BW16_17485	COG1366	Belongs to the anti-sigma-factor antagonist family
BW16_17485	COG2202	Pas domain
BW16_17490	COG0561	phosphatase activity
BW16_17505	COG1970	mechanosensitive ion channel activity
BW16_17510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BW16_17515	COG0457	Tetratricopeptide repeat
BW16_17520	COG4786	Flagellar basal body rod
BW16_17525	COG4786	Flagellar basal body rod
BW16_17535	COG1077	Cell shape determining protein MreB Mrl
BW16_17540	COG1609	Transcriptional regulator
BW16_17545	COG1846	Transcriptional regulator
BW16_17550	COG2814	Major facilitator Superfamily
BW16_17555	COG0671	phosphoesterase, PA-phosphatase related
BW16_17560	COG0477	Major facilitator Superfamily
BW16_17565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_17570	COG0765	amino acid transport
BW16_17575	COG1126	abc transporter atp-binding protein
BW16_17580	COG0004	ammonium transporteR
BW16_17585	COG0347	Belongs to the P(II) protein family
BW16_17590	COG0739	heme binding
BW16_17595	COG1247	-acetyltransferase
BW16_17605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW16_17610	COG0523	cobalamin synthesis protein
BW16_17615	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW16_17620	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BW16_17625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BW16_17640	COG2304	oxidoreductase activity
BW16_17645	COG2304	oxidoreductase activity
BW16_17650	COG2385	sporulation resulting in formation of a cellular spore
BW16_17655	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW16_17665	COG4836	Membrane
BW16_17675	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BW16_17680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BW16_17685	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BW16_17690	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BW16_17695	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW16_17700	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BW16_17705	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW16_17710	COG0356	it plays a direct role in the translocation of protons across the membrane
BW16_17725	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BW16_17730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BW16_17735	COG4475	Protein of unknown function (DUF436)
BW16_17740	COG0698	ribose 5-phosphate isomerase
BW16_17745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BW16_17750	COG1971	Probably functions as a manganese efflux pump
BW16_17755	COG0009	L-threonylcarbamoyladenylate synthase
BW16_17760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BW16_17775	COG2890	protein-(glutamine-N5) methyltransferase activity
BW16_17780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BW16_17785	COG0789	Transcriptional regulator
BW16_17790	COG0679	Auxin Efflux Carrier
BW16_17795	COG0281	malic enzyme
BW16_17800	COG1435	thymidine kinase activity
BW16_17805	COG0254	rRNA binding
BW16_17810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BW16_17815	COG1494	fructose-1,6-bisphosphatase
BW16_17820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW16_17825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW16_17830	COG0191	fructose-bisphosphate aldolase activity
BW16_17835	COG2204	response regulator
BW16_17840	COG4821	SIS domain
BW16_17845	COG0504	CTP synthase activity
BW16_17850	COG3343	RNA polymerase activity
BW16_17865	COG1960	acyl-CoA dehydrogenase activity
BW16_17870	COG1960	acyl-CoA dehydrogenase activity
BW16_17875	COG1250	3-hydroxyacyl-CoA dehydrogenase
BW16_17880	COG0183	Belongs to the thiolase family
BW16_17885	COG0247	lactate metabolic process
BW16_17885	COG2181	nitrate reductase activity
BW16_17890	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_17895	COG4294	response to UV
BW16_17905	COG1619	proteins homologs of microcin C7 resistance protein MccF
BW16_17915	COG1132	(ABC) transporter
BW16_17920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BW16_17925	COG1619	proteins homologs of microcin C7 resistance protein MccF
BW16_17935	COG0018	arginyl-trna synthetase
BW16_17940	COG4506	Protein conserved in bacteria
BW16_17950	COG0010	Belongs to the arginase family
BW16_17955	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BW16_17960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW16_17970	COG1994	Peptidase M50
BW16_17975	COG1942	4-Oxalocrotonate Tautomerase
BW16_17985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_17990	COG0583	DNA-binding transcription factor activity
BW16_17995	COG0431	NADPH-dependent FMN reductase
BW16_18000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_18005	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BW16_18010	COG0454	-acetyltransferase
BW16_18015	COG0765	amino acid transport
BW16_18025	COG0765	amino acid transport
BW16_18030	COG1126	abc transporter atp-binding protein
BW16_18035	COG3465	dGTPase activity
BW16_18040	COG1078	dGTPase activity
BW16_18045	COG4844	belongs to the
BW16_18095	COG5444	nuclease activity
BW16_18125	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BW16_18135	COG0280	phosphate acetyltransferase
BW16_18145	COG2814	Major facilitator Superfamily
BW16_18150	COG1522	sequence-specific DNA binding
BW16_18155	COG2814	Major facilitator Superfamily
BW16_18160	COG0077	Prephenate dehydratase
BW16_18165	COG1917	Cupin 2, conserved barrel domain protein
BW16_18170	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_18175	COG0151	Belongs to the GarS family
BW16_18180	COG0436	Aminotransferase
BW16_18185	COG1028	Short-chain dehydrogenase reductase Sdr
BW16_18190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BW16_18195	COG1091	dTDP-4-dehydrorhamnose reductase activity
BW16_18200	COG1088	dTDP-glucose 4,6-dehydratase activity
BW16_18205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BW16_18210	COG3980	spore coat polysaccharide biosynthesis protein
BW16_18215	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BW16_18220	COG2089	acid synthase
BW16_18225	COG0456	acetyltransferase
BW16_18230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW16_18235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BW16_18240	COG0463	Glycosyl transferase, family 2
BW16_18260	COG2363	Small membrane protein
BW16_18265	COG2233	PERMEase
BW16_18275	COG1012	belongs to the aldehyde dehydrogenase family
BW16_18280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BW16_18285	COG1216	Glycosyl transferase, family 2
BW16_18295	COG0351	phosphomethylpyrimidine kinase
BW16_18310	COG1621	beta-fructofuranosidase activity
BW16_18315	COG1263	PTS System
BW16_18315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_18320	COG3711	transcriptional antiterminator
BW16_18330	COG1404	Belongs to the peptidase S8 family
BW16_18340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BW16_18345	COG0778	Nitroreductase
BW16_18350	COG0772	Belongs to the SEDS family
BW16_18360	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BW16_18365	COG1845	cytochrome c oxidase, subunit III
BW16_18370	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BW16_18375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BW16_18385	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
BW16_18390	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BW16_18395	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BW16_18410	COG2246	polysaccharide biosynthetic process
BW16_18430	COG3162	membrane
BW16_18435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BW16_18455	COG0352	thiamine-phosphate diphosphorylase activity
BW16_18460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
BW16_18465	COG0583	DNA-binding transcription factor activity
BW16_18470	COG1380	Effector of murein hydrolase LrgA
BW16_18475	COG1346	cytolysis
BW16_18480	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BW16_18485	COG0346	lactoylglutathione lyase activity
BW16_18495	COG0765	amino acid transport
BW16_18500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW16_18510	COG0457	Tetratricopeptide repeat
BW16_18520	COG2357	RelA SpoT domain protein
BW16_18525	COG1172	Belongs to the binding-protein-dependent transport system permease family
BW16_18530	COG1129	ABC transporter
BW16_18545	COG3420	alginic acid biosynthetic process
BW16_18550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW16_18565	COG1486	melibiose metabolic process
BW16_18570	COG1447	Phosphotransferase system cellobiose-specific component IIA
BW16_18575	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_18580	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_18585	COG3711	transcriptional antiterminator
BW16_18585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BW16_18605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW16_18620	COG1595	DNA-templated transcription, initiation
BW16_18625	COG3866	Pectate lyase
BW16_18630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BW16_18635	COG4988	ABC transporter
BW16_18640	COG1294	oxidase, subunit
BW16_18645	COG1271	oxidase subunit
BW16_18650	COG1120	ATPase activity
BW16_18655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BW16_18660	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
BW16_18665	COG4509	Sortase family
BW16_18690	COG5386	Cell surface protein
BW16_18695	COG5386	Cell surface protein
BW16_18705	COG1733	regulation of RNA biosynthetic process
BW16_18710	COG2514	catechol 2,3-dioxygenase activity
BW16_18715	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_18715	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW16_18720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_18720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW16_18730	COG0726	polysaccharide deacetylase
BW16_18735	COG1447	Phosphotransferase system cellobiose-specific component IIA
BW16_18740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_18745	COG2723	6-phospho-beta-galactosidase activity
BW16_18750	COG1312	Catalyzes the dehydration of D-mannonate
BW16_18755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
BW16_18785	COG1757	Na H antiporter
BW16_18790	COG1027	Aspartate ammonia-lyase
BW16_18795	COG0252	asparaginase activity
BW16_18800	COG1396	sequence-specific DNA binding
BW16_18825	COG4842	Belongs to the WXG100 family
BW16_18830	COG2195	Cleaves the N-terminal amino acid of tripeptides
BW16_18840	COG2801	Transposase and inactivated derivatives
BW16_18855	COG1737	Transcriptional regulator
BW16_18860	COG2084	Dehydrogenase
BW16_18870	COG2610	gluconate transmembrane transporter activity
BW16_18875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BW16_18905	COG2723	6-phospho-beta-galactosidase activity
BW16_18910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_18910	COG1263	PTS System
BW16_18910	COG2190	(PTS) system
BW16_18915	COG3711	transcriptional antiterminator
BW16_18920	COG3878	Protein conserved in bacteria
BW16_18930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW16_18935	COG1122	ATPase activity
BW16_18940	COG4721	ABC-type cobalt transport system, permease component
BW16_18945	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BW16_18975	COG3291	Pkd domain containing protein
BW16_18975	COG4412	M6 family metalloprotease domain protein
BW16_18980	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
BW16_18985	COG0778	Nitroreductase
BW16_18990	COG1846	Transcriptional regulator
BW16_19000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BW16_19005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BW16_19010	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BW16_19015	COG2390	Transcriptional regulator
BW16_19025	COG2755	lipolytic protein G-D-S-L family
BW16_19025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BW16_19030	COG0477	Major facilitator Superfamily
BW16_19035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW16_19040	COG2226	methyltransferase
BW16_19050	COG0561	phosphatase activity
BW16_19055	COG0789	Transcriptional regulator
BW16_19060	COG0673	inositol 2-dehydrogenase activity
BW16_19065	COG2801	Transposase and inactivated derivatives
BW16_19075	COG0840	transmembrane signaling receptor activity
BW16_19085	COG1113	amino acid transport
BW16_19090	COG4335	DNA alkylation repair
BW16_19100	COG1070	Carbohydrate kinase
BW16_19105	COG1737	Transcriptional regulator
BW16_19150	COG0583	DNA-binding transcription factor activity
BW16_19155	COG1609	Transcriptional regulator
BW16_19160	COG2182	Extracellular solute-binding protein
BW16_19165	COG1175	transmembrane transport
BW16_19170	COG3833	ABC-type maltose transport systems, permease component
BW16_19180	COG1874	Beta-galactosidase
BW16_19215	COG2851	Citrate transporter
BW16_19225	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
BW16_19230	COG1131	(ABC) transporter
BW16_19240	COG2824	Alkylphosphonate utilization operon protein PhnA
BW16_19245	COG1929	Belongs to the glycerate kinase type-1 family
BW16_19250	COG2610	gluconate transmembrane transporter activity
BW16_19255	COG3835	regulator
BW16_19260	COG1309	transcriptional regulator
BW16_19265	COG2814	Major facilitator Superfamily
BW16_19275	COG1136	(ABC) transporter
BW16_19285	COG0457	Tetratricopeptide repeat
BW16_19290	COG3711	transcriptional antiterminator
BW16_19295	COG2723	6-phospho-beta-galactosidase activity
BW16_19300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_19300	COG2190	(PTS) system
BW16_19300	COG1263	PTS System
BW16_19330	COG0494	nUDIX hydrolase
BW16_19350	COG1113	amino acid transport
BW16_19360	COG2814	Major facilitator Superfamily
BW16_19365	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BW16_19370	COG2814	Major facilitator Superfamily
BW16_19375	COG2723	6-phospho-beta-galactosidase activity
BW16_19385	COG1263	PTS System
BW16_19385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_19385	COG2190	(PTS) system
BW16_19410	COG5444	nuclease activity
BW16_19425	COG2723	6-phospho-beta-galactosidase activity
BW16_19430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BW16_19430	COG1263	PTS System
BW16_19430	COG2190	(PTS) system
BW16_19435	COG2188	Transcriptional regulator
BW16_19450	COG0384	phenazine biosynthesis protein PhzF
BW16_19455	COG0583	DNA-binding transcription factor activity
BW16_19475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BW16_19490	COG3850	Histidine kinase
BW16_19490	COG5002	protein histidine kinase activity
BW16_19500	COG2409	Drug exporters of the RND superfamily
BW16_19505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW16_19515	COG1078	dGTPase activity
BW16_19520	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BW16_19530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW16_19540	COG4720	Psort location CytoplasmicMembrane, score
BW16_19560	COG0456	acetyltransferase
BW16_19565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW16_19570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BW16_19575	COG4853	Protein conserved in bacteria
BW16_19580	COG4863	YycH protein
BW16_19585	COG5002	protein histidine kinase activity
BW16_19590	COG0745	RESPONSE REGULATOR receiver
BW16_19615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BW16_19625	COG2311	Membrane
BW16_19630	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BW16_19635	COG1309	transcriptional regulator
BW16_19640	COG2124	cytochrome p450
BW16_19645	COG0346	lactoylglutathione lyase activity
BW16_19650	COG0305	Participates in initiation and elongation during chromosome replication
BW16_19675	COG2819	hydrolase of the alpha beta superfamily
BW16_19680	COG2207	Transcriptional regulator
BW16_19680	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_19685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW16_19690	COG2819	hydrolase of the alpha beta superfamily
BW16_19700	COG2807	transmembrane transport
BW16_19705	COG0359	binds to the 23S rRNA
BW16_19710	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BW16_19715	COG4241	membrane
BW16_19720	COG1227	inorganic diphosphatase activity
BW16_19730	COG1595	DNA-templated transcription, initiation
BW16_19740	COG0753	catalase activity
BW16_19745	COG0655	NAD(P)H dehydrogenase (quinone) activity
BW16_19750	COG0400	carboxylic ester hydrolase activity
BW16_19755	COG0346	lactoylglutathione lyase activity
BW16_19760	COG1174	glycine betaine transport
BW16_19765	COG0517	IMP dehydrogenase activity
BW16_19765	COG1125	glycine betaine transport
BW16_19770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BW16_19775	COG0629	single-stranded DNA binding
BW16_19780	COG0360	Binds together with S18 to 16S ribosomal RNA
BW16_19785	COG0012	GTP binding
BW16_19790	COG4481	Protein conserved in bacteria
BW16_19805	COG3949	Membrane
BW16_19815	COG1475	DNA binding
BW16_19820	COG1192	Involved in chromosome partitioning
BW16_19830	COG1475	DNA binding
BW16_19835	COG0357	Ribosomal RNA small subunit methyltransferase G
BW16_19840	COG0445	tRNA wobble uridine modification
BW16_19845	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BW16_19850	COG1847	R3H domain protein
BW16_19855	COG0706	membrane insertase activity
BW16_19860	COG0594	ribonuclease P activity