locus-tag	class	description
NPA43_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NPA43_00010	COG0592	DNA-directed DNA polymerase activity
NPA43_00015	COG2501	S4 domain
NPA43_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NPA43_00030	COG0187	DNA topoisomerase II activity
NPA43_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NPA43_00070	COG0516	GMP reductase activity
NPA43_00070	COG0517	IMP dehydrogenase activity
NPA43_00075	COG1686	Belongs to the peptidase S11 family
NPA43_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA43_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NPA43_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NPA43_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NPA43_00100	COG0840	transmembrane signaling receptor activity
NPA43_00110	COG1428	Deoxynucleoside kinase
NPA43_00115	COG1428	Deoxynucleoside kinase
NPA43_00120	COG1388	LysM domain
NPA43_00120	COG3858	chitin binding
NPA43_00125	COG1335	isochorismatase
NPA43_00130	COG0590	tRNA wobble adenosine to inosine editing
NPA43_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NPA43_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NPA43_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NPA43_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NPA43_00200	COG3853	Toxic anion resistance protein (TelA)
NPA43_00205	COG1982	Orn Lys Arg decarboxylase major
NPA43_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NPA43_00215	COG3870	Protein conserved in bacteria
NPA43_00220	COG1728	Protein conserved in bacteria
NPA43_00225	COG0470	DNA polymerase III
NPA43_00230	COG1774	PSP1 C-terminal conserved region
NPA43_00235	COG4467	Involved in initiation control of chromosome replication
NPA43_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NPA43_00245	COG2827	Endonuclease containing a URI domain
NPA43_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NPA43_00255	COG2002	toxin-antitoxin pair type II binding
NPA43_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA43_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA43_00265	COG0084	hydrolase, TatD family'
NPA43_00270	COG3583	domain protein
NPA43_00270	COG3584	3D domain protein
NPA43_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NPA43_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NPA43_00290	COG4466	Protein conserved in bacteria
NPA43_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NPA43_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPA43_00310	COG0251	oxidation-reduction process
NPA43_00315	COG2088	sporulation resulting in formation of a cellular spore
NPA43_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NPA43_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NPA43_00335	COG0193	aminoacyl-tRNA hydrolase activity
NPA43_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NPA43_00350	COG2002	toxin-antitoxin pair type II binding
NPA43_00355	COG2244	polysaccharide biosynthetic process
NPA43_00360	COG3956	TIGRFAM MazG family protein
NPA43_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NPA43_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NPA43_00385	COG1098	S1 RNA binding domain
NPA43_00400	COG2208	phosphoserine phosphatase activity
NPA43_00405	COG2304	oxidoreductase activity
NPA43_00410	COG0515	serine threonine protein kinase
NPA43_00415	COG0037	tRNA processing
NPA43_00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NPA43_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NPA43_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NPA43_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NPA43_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NPA43_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA43_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NPA43_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
NPA43_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA43_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NPA43_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NPA43_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NPA43_00480	COG1396	sequence-specific DNA binding
NPA43_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NPA43_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NPA43_00570	COG4463	regulation of RNA biosynthetic process
NPA43_00575	COG3880	PFAM UvrB UvrC protein
NPA43_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NPA43_00585	COG0542	response to heat
NPA43_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NPA43_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NPA43_00600	COG4956	integral membrane protein (PIN domain superfamily)
NPA43_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NPA43_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NPA43_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NPA43_00620	COG1045	serine acetyltransferase
NPA43_00625	COG0215	cysteine-tRNA ligase activity
NPA43_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NPA43_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NPA43_00640	COG3688	RNA-binding protein containing a PIN domain
NPA43_00645	COG1595	DNA-templated transcription, initiation
NPA43_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NPA43_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NPA43_00660	COG0250	Participates in transcription elongation, termination and antitermination
NPA43_00670	COG0081	regulation of translation
NPA43_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NPA43_00680	COG0222	ribosome binding
NPA43_00685	COG2813	Specifically methylates the guanine in position
NPA43_00690	COG0085	RNA polymerase activity
NPA43_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NPA43_00700	COG1358	cellular component organization or biogenesis
NPA43_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NPA43_00710	COG0049	tRNA binding
NPA43_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NPA43_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NPA43_00725	COG0596	Alpha beta hydrolase
NPA43_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NPA43_00740	COG0088	Forms part of the polypeptide exit tunnel
NPA43_00745	COG0089	rRNA binding
NPA43_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NPA43_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NPA43_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NPA43_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NPA43_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NPA43_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
NPA43_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NPA43_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NPA43_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NPA43_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NPA43_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NPA43_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NPA43_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NPA43_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NPA43_00825	COG1841	ribosomal large subunit assembly
NPA43_00830	COG0200	Binds to the 23S rRNA
NPA43_00835	COG0201	protein transport
NPA43_00840	COG0563	adenylate kinase activity
NPA43_00845	COG0024	Methionine aminopeptidase
NPA43_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NPA43_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NPA43_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NPA43_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NPA43_00875	COG0202	RNA polymerase activity
NPA43_00880	COG0203	ribosomal protein L17
NPA43_00885	COG1122	ATPase activity
NPA43_00890	COG1122	ATPase activity
NPA43_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPA43_00900	COG0101	tRNA pseudouridine synthase activity
NPA43_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NPA43_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NPA43_00915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA43_00945	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA43_00950	COG0489	protein tyrosine kinase activity
NPA43_00960	COG2194	sulfuric ester hydrolase activity
NPA43_00965	COG0726	polysaccharide deacetylase
NPA43_00995	COG0659	secondary active sulfate transmembrane transporter activity
NPA43_01000	COG0385	Bile acid
NPA43_01005	COG3876	Protein conserved in bacteria
NPA43_01010	COG1472	Belongs to the glycosyl hydrolase 3 family
NPA43_01015	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NPA43_01020	COG1263	PTS System
NPA43_01020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_01025	COG1737	Transcriptional regulator
NPA43_01030	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NPA43_01065	COG1595	DNA-templated transcription, initiation
NPA43_01070	COG5662	AntiSigma factor
NPA43_01075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NPA43_01080	COG4856	YbbR-like protein
NPA43_01085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NPA43_01090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NPA43_01105	COG1131	(ABC) transporter
NPA43_01125	COG0535	radical SAM domain protein
NPA43_01130	COG1266	CAAX protease self-immunity
NPA43_01135	COG1131	(ABC) transporter
NPA43_01145	COG1413	lyase activity
NPA43_01150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_01160	COG2311	Membrane
NPA43_01180	COG2207	Transcriptional regulator
NPA43_01185	COG1309	transcriptional regulator
NPA43_01200	COG1113	amino acid transport
NPA43_01205	COG0584	glycerophosphoryl diester phosphodiesterase
NPA43_01210	COG2271	Major facilitator Superfamily
NPA43_01220	COG1331	Highly conserved protein containing a thioredoxin domain
NPA43_01235	COG1131	(ABC) transporter
NPA43_01265	COG1937	Protein conserved in bacteria
NPA43_01270	COG2210	Belongs to the sulfur carrier protein TusA family
NPA43_01280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPA43_01280	COG0425	Belongs to the sulfur carrier protein TusA family
NPA43_01285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA43_01285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPA43_01290	COG0425	Belongs to the sulfur carrier protein TusA family
NPA43_01295	COG0730	response to heat
NPA43_01305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NPA43_01310	COG2814	Major facilitator Superfamily
NPA43_01320	COG1846	Transcriptional regulator
NPA43_01330	COG1683	Conserved Protein
NPA43_01340	COG0656	L-ascorbic acid biosynthetic process
NPA43_01345	COG0371	Dehydrogenase
NPA43_01350	COG1054	Belongs to the UPF0176 family
NPA43_01355	COG0531	amino acid
NPA43_01365	COG3711	transcriptional antiterminator
NPA43_01370	COG2190	(PTS) system
NPA43_01370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_01370	COG1263	PTS System
NPA43_01375	COG2723	6-phospho-beta-galactosidase activity
NPA43_01405	COG3711	transcriptional antiterminator
NPA43_01405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_01410	COG1940	carbohydrate kinase activity
NPA43_01415	COG0383	alpha-mannosidase activity
NPA43_01420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_01425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_01435	COG1404	Belongs to the peptidase S8 family
NPA43_01445	COG0833	amino acid
NPA43_01450	COG2040	homocysteine
NPA43_01455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA43_01475	COG2814	Major facilitator Superfamily
NPA43_01480	COG0456	acetyltransferase
NPA43_01495	COG1404	Belongs to the peptidase S8 family
NPA43_01505	COG1309	transcriptional regulator
NPA43_01510	COG1917	Cupin 2, conserved barrel domain protein
NPA43_01515	COG1063	alcohol dehydrogenase
NPA43_01520	COG1846	Transcriptional regulator
NPA43_01525	COG0318	PFAM AMP-dependent synthetase and ligase
NPA43_01530	COG0531	amino acid
NPA43_01540	COG0596	Alpha beta hydrolase
NPA43_01550	COG2066	Belongs to the glutaminase family
NPA43_01555	COG4191	Histidine kinase
NPA43_01560	COG0784	Response regulator, receiver
NPA43_01565	COG3012	SEC-C Motif Domain Protein
NPA43_01565	COG1405	negative regulation of cell septum assembly
NPA43_01575	COG0667	Aldo Keto reductase
NPA43_01580	COG3290	protein histidine kinase activity
NPA43_01585	COG3279	Response regulator of the LytR AlgR family
NPA43_01590	COG4555	ABC transporter
NPA43_01595	COG1668	transmembrane transport
NPA43_01620	COG1404	Belongs to the peptidase S8 family
NPA43_01630	COG3773	Cell wall hydrolase
NPA43_01635	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_01645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA43_01650	COG2310	stress, protein
NPA43_01655	COG2310	stress, protein
NPA43_01660	COG2310	stress, protein
NPA43_01665	COG0861	Integral membrane protein TerC family
NPA43_01695	COG3853	Toxic anion resistance protein (TelA)
NPA43_01700	COG0517	IMP dehydrogenase activity
NPA43_01700	COG4175	Glycine betaine
NPA43_01705	COG4176	ABC-type proline glycine betaine transport system permease component
NPA43_01710	COG2113	Glycine betaine
NPA43_01725	COG1473	amidohydrolase
NPA43_01730	COG1288	antiporter activity
NPA43_01735	COG0039	L-malate dehydrogenase activity
NPA43_01740	COG1620	l-lactate permease
NPA43_01745	COG1609	Transcriptional regulator
NPA43_01750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA43_01755	COG0561	phosphatase activity
NPA43_01760	COG0673	inositol 2-dehydrogenase activity
NPA43_01765	COG0738	Major facilitator superfamily
NPA43_01770	COG1280	lysine exporter protein (LysE YggA)
NPA43_01780	COG3403	YqcI/YcgG family
NPA43_01785	COG1113	amino acid transport
NPA43_01790	COG3665	Urea carboxylase-associated protein
NPA43_01795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NPA43_01805	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_01810	COG0710	3-dehydroquinate dehydratase activity
NPA43_01825	COG1804	L-carnitine dehydratase bile acid-inducible protein F
NPA43_01830	COG2271	Major facilitator Superfamily
NPA43_01845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NPA43_01850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NPA43_01855	COG3458	cephalosporin-C deacetylase activity
NPA43_01865	COG3541	Predicted nucleotidyltransferase
NPA43_01870	COG0506	proline dehydrogenase activity
NPA43_01875	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_01880	COG2508	Transcriptional regulator
NPA43_01885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NPA43_01890	COG0765	amino acid transport
NPA43_01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_01905	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NPA43_01910	COG1522	sequence-specific DNA binding
NPA43_01915	COG2746	aminoglycoside 3-N-acetyltransferase activity
NPA43_01925	COG3209	COG3209 Rhs family protein
NPA43_01945	COG3842	ATPase activity
NPA43_01960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA43_01965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA43_01970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA43_01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NPA43_01990	COG0697	spore germination
NPA43_01995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA43_02005	COG2364	Membrane
NPA43_02010	COG0737	Belongs to the 5'-nucleotidase family
NPA43_02015	COG3764	Sortase (surface protein transpeptidase)
NPA43_02020	COG2002	toxin-antitoxin pair type II binding
NPA43_02025	COG1126	abc transporter atp-binding protein
NPA43_02030	COG0765	amino acid transport
NPA43_02035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_02040	COG0412	Dienelactone hydrolase
NPA43_02045	COG0833	amino acid
NPA43_02050	COG3104	oligopeptide transport
NPA43_02055	COG5434	Belongs to the glycosyl hydrolase 28 family
NPA43_02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA43_02065	COG0456	acetyltransferase
NPA43_02070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_02075	COG0765	amino acid transport
NPA43_02080	COG1126	abc transporter atp-binding protein
NPA43_02085	COG1473	amidohydrolase
NPA43_02090	COG2079	MmgE PrpD family protein
NPA43_02100	COG0745	RESPONSE REGULATOR receiver
NPA43_02105	COG5002	protein histidine kinase activity
NPA43_02105	COG3850	Histidine kinase
NPA43_02110	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_02115	COG0527	aspartate kinase activity
NPA43_02120	COG2814	Major facilitator Superfamily
NPA43_02125	COG1309	transcriptional regulator
NPA43_02130	COG0640	Transcriptional regulator
NPA43_02135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA43_02140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NPA43_02145	COG0531	amino acid
NPA43_02150	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_02155	COG2249	NAD(P)H dehydrogenase (quinone) activity
NPA43_02160	COG4549	nuclear export factor GLE1
NPA43_02165	COG2372	response to copper ion
NPA43_02165	COG1276	copper resistance
NPA43_02170	COG2213	PTS system mannitol-specific
NPA43_02175	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_02180	COG0246	Mannitol dehydrogenase
NPA43_02185	COG0840	transmembrane signaling receptor activity
NPA43_02205	COG0346	lactoylglutathione lyase activity
NPA43_02215	COG0561	phosphatase activity
NPA43_02220	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NPA43_02225	COG1914	H( )-stimulated, divalent metal cation uptake system
NPA43_02230	COG4336	lyase activity
NPA43_02235	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NPA43_02240	COG1984	allophanate hydrolase subunit 2
NPA43_02245	COG1414	Transcriptional regulator
NPA43_02250	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NPA43_02255	COG2755	lipolytic protein G-D-S-L family
NPA43_02265	COG3711	transcriptional antiterminator
NPA43_02270	COG2226	methyltransferase
NPA43_02275	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_02280	COG3871	stress protein (general stress protein 26)
NPA43_02305	COG2814	Major facilitator Superfamily
NPA43_02310	COG1802	Transcriptional regulator
NPA43_02315	COG2207	Transcriptional regulator
NPA43_02315	COG1917	Cupin 2, conserved barrel domain protein
NPA43_02320	COG0697	spore germination
NPA43_02325	COG0473	3-isopropylmalate dehydrogenase activity
NPA43_02330	COG0551	DNA topoisomerase type I activity
NPA43_02330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NPA43_02335	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NPA43_02340	COG3706	GGDEF domain
NPA43_02345	COG5298	Protein conserved in bacteria
NPA43_02350	COG1215	transferase activity, transferring glycosyl groups
NPA43_02360	COG0531	amino acid
NPA43_02365	COG0028	Belongs to the TPP enzyme family
NPA43_02370	COG5444	nuclease activity
NPA43_02400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA43_02405	COG1914	H( )-stimulated, divalent metal cation uptake system
NPA43_02410	COG2261	transglycosylase associated protein
NPA43_02415	COG2217	Heavy metal translocating P-type atpase
NPA43_02420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NPA43_02425	COG3290	protein histidine kinase activity
NPA43_02430	COG4565	transcriptional regulatory protein
NPA43_02435	COG1301	dicarboxylic acid transport
NPA43_02440	COG0628	permease
NPA43_02445	COG1301	dicarboxylic acid transport
NPA43_02450	COG1131	(ABC) transporter
NPA43_02455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NPA43_02470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_02475	COG1181	Belongs to the D-alanine--D-alanine ligase family
NPA43_02480	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NPA43_02495	COG0513	Belongs to the DEAD box helicase family
NPA43_02500	COG3402	PFAM membrane-flanked domain
NPA43_02505	COG3428	Bacterial PH domain
NPA43_02510	COG0705	Rhomboid family
NPA43_02515	COG0736	holo-[acyl-carrier-protein] synthase activity
NPA43_02520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NPA43_02525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NPA43_02530	COG0864	Transcriptional regulator
NPA43_02535	COG2337	Toxic component of a toxin-antitoxin (TA) module
NPA43_02540	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_02545	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_02550	COG2172	sigma factor antagonist activity
NPA43_02555	COG2208	phosphoserine phosphatase activity
NPA43_02560	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_02565	COG2172	sigma factor antagonist activity
NPA43_02570	COG1191	sigma factor activity
NPA43_02575	COG2208	phosphoserine phosphatase activity
NPA43_02580	COG2183	response to ionizing radiation
NPA43_02595	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA43_02600	COG0022	dehydrogenase e1 component
NPA43_02605	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA43_02610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA43_02615	COG3284	Transcriptional regulator
NPA43_02670	COG1278	Cold shock
NPA43_02675	COG1329	Transcriptional regulator
NPA43_02680	COG1064	alcohol dehydrogenase
NPA43_02685	COG0789	Transcriptional regulator
NPA43_02700	COG0477	Major facilitator Superfamily
NPA43_02705	COG0657	acetylesterase activity
NPA43_02745	COG0252	asparaginase activity
NPA43_02765	COG2814	Major facilitator Superfamily
NPA43_02805	COG1309	transcriptional regulator
NPA43_02810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NPA43_02815	COG1846	Transcriptional regulator
NPA43_02820	COG0778	Nitroreductase
NPA43_02835	COG1396	sequence-specific DNA binding
NPA43_02855	COG4122	O-methyltransferase activity
NPA43_02865	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NPA43_02870	COG0697	spore germination
NPA43_02880	COG1301	dicarboxylic acid transport
NPA43_02920	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NPA43_02925	COG0802	atpase or kinase
NPA43_02930	COG1214	PFAM Peptidase M22, glycoprotease
NPA43_02935	COG0456	acetyltransferase
NPA43_02940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NPA43_02945	COG0488	(ABC) transporter
NPA43_02950	COG0315	cyclic pyranopterin monophosphate synthase activity
NPA43_02955	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NPA43_02960	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NPA43_02965	COG0805	protein transport
NPA43_02985	COG1266	CAAX protease self-immunity
NPA43_02990	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NPA43_02995	COG0459	protein refolding
NPA43_03000	COG1846	Transcriptional regulator
NPA43_03005	COG0456	acetyltransferase
NPA43_03010	COG2808	Putative FMN-binding domain
NPA43_03030	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NPA43_03035	COG0823	Involved in the tonB-independent uptake of proteins
NPA43_03045	COG2132	Multicopper oxidase
NPA43_03050	COG1113	amino acid transport
NPA43_03055	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPA43_03060	COG0714	Associated with various cellular activities
NPA43_03065	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NPA43_03070	COG1305	Transglutaminase-like
NPA43_03075	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NPA43_03075	COG0519	Catalyzes the synthesis of GMP from XMP
NPA43_03080	COG0662	Cupin 2, conserved barrel domain protein
NPA43_03085	COG2207	Transcriptional regulator
NPA43_03105	COG2814	Major facilitator Superfamily
NPA43_03110	COG0583	DNA-binding transcription factor activity
NPA43_03115	COG2252	PERMEase
NPA43_03120	COG3064	Membrane
NPA43_03125	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NPA43_03135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NPA43_03140	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NPA43_03145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NPA43_03150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NPA43_03155	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NPA43_03160	COG0047	phosphoribosylformylglycinamidine synthase activity
NPA43_03165	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NPA43_03170	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NPA43_03175	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NPA43_03180	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NPA43_03185	COG0138	bifunctional purine biosynthesis protein purh
NPA43_03190	COG0151	Belongs to the GarS family
NPA43_03205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NPA43_03210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NPA43_03215	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NPA43_03220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPA43_03230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NPA43_03235	COG4496	protein, YerC YecD
NPA43_03240	COG0069	glutamate synthase activity
NPA43_03255	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NPA43_03260	COG0210	DNA helicase
NPA43_03265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NPA43_03270	COG4851	CamS sex pheromone cAM373 precursor
NPA43_03300	COG1250	3-hydroxyacyl-CoA dehydrogenase
NPA43_03315	COG1960	acyl-CoA dehydrogenase activity
NPA43_03335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA43_03335	COG0300	oxidoreductase activity
NPA43_03335	COG3321	synthase
NPA43_03335	COG4221	oxidoreductase activity
NPA43_03345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NPA43_03350	COG1785	Belongs to the alkaline phosphatase family
NPA43_03355	COG1285	pathogenesis
NPA43_03360	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA43_03365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NPA43_03370	COG0154	amidase activity
NPA43_03375	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NPA43_03380	COG1309	transcriptional regulator
NPA43_03385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NPA43_03390	COG1957	nucleoside hydrolase
NPA43_03395	COG1597	lipid kinase activity
NPA43_03400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NPA43_03425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NPA43_03440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_03440	COG1263	PTS System
NPA43_03445	COG1486	melibiose metabolic process
NPA43_03455	COG1959	2 iron, 2 sulfur cluster binding
NPA43_03460	COG0492	ferredoxin-NADP+ reductase activity
NPA43_03475	COG1486	melibiose metabolic process
NPA43_03485	COG2211	Major facilitator Superfamily
NPA43_03515	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NPA43_03520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA43_03525	COG1442	glycosyl transferase family 8
NPA43_03530	COG1216	Glycosyl transferase, family 2
NPA43_03535	COG1442	glycosyl transferase family 8
NPA43_03540	COG2223	nitrite transmembrane transporter activity
NPA43_03550	COG3397	chitin binding
NPA43_03560	COG0471	metal ion transport
NPA43_03570	COG0531	amino acid
NPA43_03575	COG0457	Tetratricopeptide repeat
NPA43_03575	COG0463	Glycosyl transferase, family 2
NPA43_03580	COG0488	(ABC) transporter
NPA43_03590	COG0789	Transcriptional regulator
NPA43_03595	COG2814	Major facilitator Superfamily
NPA43_03600	COG0488	(ABC) transporter
NPA43_03605	COG0513	Belongs to the DEAD box helicase family
NPA43_03610	COG2130	NADP-dependent
NPA43_03635	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPA43_03635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPA43_03640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NPA43_03650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NPA43_03650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NPA43_03660	COG3290	protein histidine kinase activity
NPA43_03665	COG4565	transcriptional regulatory protein
NPA43_03670	COG3181	Tripartite tricarboxylate transporter family receptor
NPA43_03675	COG2851	Citrate transporter
NPA43_03685	COG3479	Phenolic acid decarboxylase
NPA43_03690	COG1695	Transcriptional regulator
NPA43_03695	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NPA43_03700	COG1254	Belongs to the acylphosphatase family
NPA43_03720	COG2258	MOSC domain
NPA43_03735	COG0024	Methionine aminopeptidase
NPA43_03740	COG1263	PTS System
NPA43_03740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_03745	COG3739	integral membrane protein
NPA43_03760	COG1368	sulfuric ester hydrolase activity
NPA43_03765	COG0076	glutamate decarboxylase activity
NPA43_03780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_03780	COG1263	PTS System
NPA43_03785	COG0366	Alpha amylase catalytic
NPA43_03790	COG2188	Transcriptional regulator
NPA43_03800	COG0737	Belongs to the 5'-nucleotidase family
NPA43_03805	COG0693	protein deglycase activity
NPA43_03810	COG4840	Belongs to the UPF0435 family
NPA43_03815	COG1115	amino acid carrier protein
NPA43_03820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA43_03825	COG4980	gas vesicle protein
NPA43_03830	COG1295	ribonuclease BN
NPA43_03840	COG0477	Major facilitator Superfamily
NPA43_03850	COG0387	Pfam Sodium calcium exchanger
NPA43_03860	COG0217	transcriptional regulatory protein
NPA43_03870	COG0668	transmembrane transport
NPA43_03875	COG0535	radical SAM domain protein
NPA43_03885	COG0726	polysaccharide deacetylase
NPA43_03890	COG0598	Magnesium transport protein CorA
NPA43_03900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NPA43_03905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NPA43_03920	COG0583	DNA-binding transcription factor activity
NPA43_03925	COG1942	4-Oxalocrotonate Tautomerase
NPA43_03930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NPA43_03965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA43_03970	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPA43_03975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA43_03980	COG1486	melibiose metabolic process
NPA43_03985	COG2188	Transcriptional regulator
NPA43_03990	COG3394	polysaccharide catabolic process
NPA43_04010	COG2076	Multidrug Resistance protein
NPA43_04015	COG2076	Multidrug Resistance protein
NPA43_04020	COG1309	transcriptional regulator
NPA43_04030	COG4637	Psort location Cytoplasmic, score
NPA43_04035	COG2755	lipolytic protein G-D-S-L family
NPA43_04040	COG0492	ferredoxin-NADP+ reductase activity
NPA43_04050	COG1595	DNA-templated transcription, initiation
NPA43_04065	COG2318	DinB family
NPA43_04075	COG1846	Transcriptional regulator
NPA43_04080	COG0392	lysyltransferase activity
NPA43_04080	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NPA43_04100	COG0778	Nitroreductase
NPA43_04115	COG1090	epimerase
NPA43_04120	COG2137	regulation of response to DNA damage stimulus
NPA43_04145	COG0463	Glycosyl transferase, family 2
NPA43_04150	COG4485	Bacterial membrane protein, YfhO
NPA43_04165	COG2140	Oxalate decarboxylase
NPA43_04175	COG1191	sigma factor activity
NPA43_04185	COG1988	membrane-bound metal-dependent
NPA43_04190	COG1194	a g-specific adenine glycosylase
NPA43_04200	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_04215	COG3557	Belongs to the UPF0374 family
NPA43_04220	COG1132	(ABC) transporter
NPA43_04225	COG0444	Belongs to the ABC transporter superfamily
NPA43_04230	COG4608	Belongs to the ABC transporter superfamily
NPA43_04235	COG0747	negative chemotaxis
NPA43_04240	COG0601	transmembrane transport
NPA43_04245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA43_04250	COG4129	membrane
NPA43_04255	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NPA43_04260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NPA43_04265	COG0735	belongs to the Fur family
NPA43_04405	COG1368	sulfuric ester hydrolase activity
NPA43_04410	COG0681	Belongs to the peptidase S26 family
NPA43_04415	COG2873	o-acetylhomoserine
NPA43_04425	COG1131	(ABC) transporter
NPA43_04455	COG3382	B3 4 domain protein
NPA43_04460	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NPA43_04470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NPA43_04480	COG2766	serine protein kinase
NPA43_04485	COG2718	Belongs to the UPF0229 family
NPA43_04490	COG1566	PFAM secretion protein HlyD family protein
NPA43_04495	COG2814	Major facilitator Superfamily
NPA43_04500	COG0655	NAD(P)H dehydrogenase (quinone) activity
NPA43_04510	COG1278	Cold shock
NPA43_04515	COG3706	GGDEF domain
NPA43_04540	COG5577	PFAM Coat F domain
NPA43_04545	COG5002	protein histidine kinase activity
NPA43_04550	COG0737	Belongs to the 5'-nucleotidase family
NPA43_04550	COG1525	nuclease
NPA43_04550	COG4085	toxin activity
NPA43_04555	COG3764	Sortase (surface protein transpeptidase)
NPA43_04560	COG0564	pseudouridine synthase activity
NPA43_04570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NPA43_04575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NPA43_04575	COG3153	acetyltransferase
NPA43_04595	COG3835	regulator
NPA43_04600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NPA43_04605	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NPA43_04610	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NPA43_04615	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NPA43_04620	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NPA43_04625	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NPA43_04630	COG2203	Gaf domain
NPA43_04630	COG4585	Histidine kinase
NPA43_04635	COG2197	response regulator
NPA43_04650	COG0753	catalase activity
NPA43_04655	COG1959	2 iron, 2 sulfur cluster binding
NPA43_04660	COG1017	nitric oxide dioxygenase activity
NPA43_04660	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NPA43_04665	COG2719	SpoVR family
NPA43_04670	COG1785	Belongs to the alkaline phosphatase family
NPA43_04675	COG1388	LysM domain
NPA43_04675	COG0791	NLP P60 protein
NPA43_04695	COG1595	DNA-templated transcription, initiation
NPA43_04700	COG0204	Acyl-transferase
NPA43_04705	COG1253	flavin adenine dinucleotide binding
NPA43_04710	COG0789	Transcriptional regulator
NPA43_04715	COG1253	flavin adenine dinucleotide binding
NPA43_04730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NPA43_04735	COG0584	glycerophosphoryl diester phosphodiesterase
NPA43_04745	COG0668	transmembrane transport
NPA43_04750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NPA43_04755	COG0726	polysaccharide deacetylase
NPA43_04760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA43_04765	COG0589	response to stress
NPA43_04770	COG1132	(ABC) transporter
NPA43_04775	COG1132	(ABC) transporter
NPA43_04780	COG0702	epimerase
NPA43_04790	COG3842	ATPase activity
NPA43_04795	COG2508	Transcriptional regulator
NPA43_04805	COG0189	ligase activity
NPA43_04810	COG0189	ligase activity
NPA43_04815	COG4399	Belongs to the UPF0754 family
NPA43_04820	COG3679	Belongs to the UPF0342 family
NPA43_04830	COG0561	phosphatase activity
NPA43_04835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NPA43_04840	COG0475	glutathione-regulated potassium exporter activity
NPA43_04845	COG0490	domain, Protein
NPA43_04850	COG1024	Enoyl-CoA hydratase
NPA43_04860	COG0420	3'-5' exonuclease activity
NPA43_04865	COG4717	serine-type aminopeptidase activity
NPA43_04870	COG3481	metal-dependent phosphohydrolase, HD sub domain
NPA43_04880	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NPA43_04910	COG1846	Transcriptional regulator
NPA43_04915	COG4980	gas vesicle protein
NPA43_04930	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NPA43_04935	COG0537	adenosine 5'-monophosphoramidase activity
NPA43_04940	COG1131	(ABC) transporter
NPA43_04945	COG4473	ABC transporter
NPA43_04955	COG1473	amidohydrolase
NPA43_04960	COG2329	Antibiotic biosynthesis monooxygenase
NPA43_04965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA43_04970	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NPA43_04975	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NPA43_04980	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NPA43_04985	COG1309	transcriptional regulator
NPA43_04990	COG1511	domain protein
NPA43_04995	COG1363	Peptidase, m42
NPA43_05000	COG1301	dicarboxylic acid transport
NPA43_05010	COG1234	tRNA 3'-trailer cleavage
NPA43_05015	COG0095	Lipoate-protein ligase
NPA43_05020	COG0318	PFAM AMP-dependent synthetase and ligase
NPA43_05030	COG0501	Belongs to the peptidase M48B family
NPA43_05035	COG1404	Belongs to the peptidase S8 family
NPA43_05040	COG0406	alpha-ribazole phosphatase activity
NPA43_05045	COG0840	transmembrane signaling receptor activity
NPA43_05050	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NPA43_05050	COG0723	plastoquinol--plastocyanin reductase activity
NPA43_05055	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_05065	COG4903	ComK protein
NPA43_05075	COG2964	Protein conserved in bacteria
NPA43_05080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA43_05085	COG0662	Cupin 2, conserved barrel domain protein
NPA43_05095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA43_05100	COG2814	Major facilitator Superfamily
NPA43_05105	COG2732	(Barnase) inhibitor
NPA43_05110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_05115	COG4605	iron ion homeostasis
NPA43_05120	COG4604	ABC transporter, ATP-binding protein
NPA43_05125	COG4607	ABC-type enterochelin transport system periplasmic component
NPA43_05130	COG1316	TRANSCRIPTIONal
NPA43_05140	COG0398	Pfam SNARE associated Golgi protein
NPA43_05145	COG0681	Belongs to the peptidase S26 family
NPA43_05150	COG3180	Ammonia monooxygenase
NPA43_05165	COG2259	Doxx family
NPA43_05170	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NPA43_05175	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NPA43_05180	COG1074	ATP-dependent DNA helicase activity
NPA43_05185	COG0420	3'-5' exonuclease activity
NPA43_05190	COG0419	ATPase involved in DNA repair
NPA43_05195	COG1403	HNH endonuclease
NPA43_05235	COG5337	Spore coat protein CotH
NPA43_05245	COG0179	Fumarylacetoacetate (FAA) hydrolase
NPA43_05260	COG0367	asparagine synthase
NPA43_05275	COG1562	ergosterol biosynthetic process
NPA43_05280	COG0534	Mate efflux family protein
NPA43_05285	COG1917	Cupin 2, conserved barrel domain protein
NPA43_05285	COG2207	Transcriptional regulator
NPA43_05315	COG0076	glutamate decarboxylase activity
NPA43_05350	COG0646	methionine synthase
NPA43_05350	COG1410	methionine synthase
NPA43_05355	COG0646	methionine synthase
NPA43_05355	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NPA43_05360	COG1666	GTP binding
NPA43_05365	COG2996	Protein conserved in bacteria
NPA43_05370	COG1744	ABC transporter substrate-binding protein PnrA-like
NPA43_05375	COG0840	transmembrane signaling receptor activity
NPA43_05380	COG1307	EDD domain protein, DegV family
NPA43_05385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA43_05405	COG0561	phosphatase activity
NPA43_05410	COG1073	alpha beta
NPA43_05415	COG2151	metal-sulfur cluster biosynthetic enzyme
NPA43_05420	COG0277	FAD linked oxidase domain protein
NPA43_05425	COG2271	Major facilitator Superfamily
NPA43_05430	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NPA43_05435	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NPA43_05440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NPA43_05445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NPA43_05450	COG0505	Belongs to the CarA family
NPA43_05455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NPA43_05460	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NPA43_05470	COG2814	Major facilitator Superfamily
NPA43_05480	COG2267	carboxylic ester hydrolase activity
NPA43_05490	COG1744	ABC transporter substrate-binding protein PnrA-like
NPA43_05505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPA43_05510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NPA43_05515	COG5504	Zn-dependent protease
NPA43_05520	COG0444	Belongs to the ABC transporter superfamily
NPA43_05525	COG4608	Belongs to the ABC transporter superfamily
NPA43_05535	COG0601	transmembrane transport
NPA43_05540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA43_05550	COG0180	Tryptophanyl-tRNA synthetase
NPA43_05555	COG4166	transmembrane transport
NPA43_05560	COG0601	transmembrane transport
NPA43_05565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA43_05570	COG0444	Belongs to the ABC transporter superfamily
NPA43_05575	COG4608	Belongs to the ABC transporter superfamily
NPA43_05585	COG0456	acetyltransferase
NPA43_05590	COG1393	Belongs to the ArsC family
NPA43_05595	COG0861	Integral membrane protein TerC family
NPA43_05600	COG4862	establishment of competence for transformation
NPA43_05605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA43_05615	COG1164	Oligoendopeptidase f
NPA43_05625	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NPA43_05630	COG2346	COG2346, Truncated hemoglobins
NPA43_05635	COG0741	lytic transglycosylase activity
NPA43_05640	COG4116	CYTH
NPA43_05650	COG2357	RelA SpoT domain protein
NPA43_05655	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NPA43_05660	COG0564	pseudouridine synthase activity
NPA43_05665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NPA43_05670	COG0475	glutathione-regulated potassium exporter activity
NPA43_05670	COG0569	domain protein
NPA43_05675	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NPA43_05680	COG0352	thiamine-phosphate diphosphorylase activity
NPA43_05690	COG2104	thiamine diphosphate biosynthetic process
NPA43_05695	COG2022	thiamine diphosphate biosynthetic process
NPA43_05700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NPA43_05705	COG0351	phosphomethylpyrimidine kinase
NPA43_05710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NPA43_05770	COG0210	DNA helicase
NPA43_05780	COG2153	protein acetylation
NPA43_05785	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NPA43_05790	COG2382	esterase
NPA43_05795	COG0626	cystathionine gamma-synthase activity
NPA43_05800	COG0626	cystathionine gamma-synthase activity
NPA43_05825	COG0457	Tetratricopeptide repeat
NPA43_05835	COG0693	protein deglycase activity
NPA43_05855	COG2807	transmembrane transport
NPA43_05865	COG1280	lysine exporter protein (LysE YggA)
NPA43_05890	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NPA43_05900	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPA43_05905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPA43_05930	COG4195	phage-related replication protein
NPA43_05935	COG2856	Zn peptidase
NPA43_05940	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA43_05940	COG3409	Peptidoglycan-binding domain 1 protein
NPA43_05960	COG0306	phosphate transporter
NPA43_05965	COG1392	Phosphate transport regulator
NPA43_05975	COG0405	Gamma-glutamyltransferase
NPA43_05990	COG3775	system Galactitol-specific IIC component
NPA43_06005	COG1063	alcohol dehydrogenase
NPA43_06010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA43_06015	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA43_06015	COG0022	dehydrogenase e1 component
NPA43_06020	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA43_06025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA43_06030	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_06035	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_06040	COG2390	Transcriptional regulator
NPA43_06050	COG0531	amino acid
NPA43_06055	COG0346	lactoylglutathione lyase activity
NPA43_06060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA43_06065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA43_06070	COG2362	D-Aminopeptidase
NPA43_06075	COG0601	transmembrane transport
NPA43_06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA43_06085	COG0444	Belongs to the ABC transporter superfamily
NPA43_06090	COG4166	transmembrane transport
NPA43_06095	COG1619	proteins homologs of microcin C7 resistance protein MccF
NPA43_06100	COG4948	Mandelate Racemase Muconate Lactonizing
NPA43_06105	COG0791	NLP P60 protein
NPA43_06110	COG4608	Belongs to the ABC transporter superfamily
NPA43_06115	COG1834	amidinotransferase
NPA43_06120	COG1607	acyl-coa hydrolase
NPA43_06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA43_06150	COG2076	Multidrug Resistance protein
NPA43_06155	COG2076	Multidrug Resistance protein
NPA43_06165	COG0788	formyltetrahydrofolate deformylase activity
NPA43_06170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NPA43_06175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NPA43_06180	COG0457	Tetratricopeptide repeat
NPA43_06190	COG1764	response to oxidative stress
NPA43_06195	COG1846	Transcriptional regulator
NPA43_06200	COG1764	response to oxidative stress
NPA43_06205	COG0590	tRNA wobble adenosine to inosine editing
NPA43_06210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NPA43_06215	COG1404	Belongs to the peptidase S8 family
NPA43_06220	COG0745	RESPONSE REGULATOR receiver
NPA43_06225	COG3850	Histidine kinase
NPA43_06225	COG5002	protein histidine kinase activity
NPA43_06230	COG3212	peptidase
NPA43_06235	COG3212	peptidase
NPA43_06245	COG2239	Acts as a magnesium transporter
NPA43_06255	COG0789	Transcriptional regulator
NPA43_06270	COG1846	Transcriptional regulator
NPA43_06275	COG3300	MHYT domain
NPA43_06275	COG5001	Diguanylate cyclase
NPA43_06280	COG0586	Pfam SNARE associated Golgi protein
NPA43_06285	COG0861	Integral membrane protein TerC family
NPA43_06290	COG1191	sigma factor activity
NPA43_06310	COG0501	Belongs to the peptidase M48B family
NPA43_06315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NPA43_06320	COG2323	membrane
NPA43_06335	COG3594	Acyltransferase
NPA43_06340	COG5002	protein histidine kinase activity
NPA43_06345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NPA43_06355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NPA43_06360	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NPA43_06365	COG0436	Aminotransferase
NPA43_06370	COG1850	ribulose-bisphosphate carboxylase activity
NPA43_06375	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NPA43_06380	COG0235	Class ii aldolase
NPA43_06385	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NPA43_06395	COG3852	Histidine kinase
NPA43_06400	COG1846	Transcriptional regulator
NPA43_06405	COG1360	Flagellar Motor Protein
NPA43_06410	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NPA43_06415	COG0542	response to heat
NPA43_06420	COG3949	Membrane
NPA43_06425	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NPA43_06430	COG0720	synthase
NPA43_06435	COG0602	queuosine metabolic process
NPA43_06440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NPA43_06450	COG4873	Protein conserved in bacteria
NPA43_06460	COG3773	Cell wall hydrolase
NPA43_06465	COG2244	polysaccharide biosynthetic process
NPA43_06470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_06475	COG2217	Heavy metal translocating P-type atpase
NPA43_06480	COG0006	proline dipeptidase activity
NPA43_06490	COG1609	Transcriptional regulator
NPA43_06495	COG3711	transcriptional antiterminator
NPA43_06500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_06500	COG2190	(PTS) system
NPA43_06500	COG1263	PTS System
NPA43_06505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_06510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NPA43_06520	COG1533	DNA photolyase activity
NPA43_06525	COG0840	transmembrane signaling receptor activity
NPA43_06530	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_06535	COG2084	Dehydrogenase
NPA43_06540	COG2340	Cysteine-rich secretory protein family
NPA43_06545	COG0768	penicillin binding
NPA43_06550	COG4191	Histidine kinase
NPA43_06555	COG0436	Aminotransferase
NPA43_06560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NPA43_06570	COG1714	RDD family
NPA43_06580	COG0835	chemotaxis
NPA43_06580	COG0784	Response regulator, receiver
NPA43_06605	COG2814	Major facilitator Superfamily
NPA43_06610	COG1376	ErfK ybiS ycfS ynhG family protein
NPA43_06615	COG1408	metallophosphoesterase
NPA43_06620	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_06625	COG2200	EAL domain
NPA43_06630	COG3546	catalase activity
NPA43_06635	COG4703	Protein of unknown function (DUF1797)
NPA43_06640	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NPA43_06650	COG0517	IMP dehydrogenase activity
NPA43_06655	COG0583	DNA-binding transcription factor activity
NPA43_06665	COG0716	FMN binding
NPA43_06675	COG0716	FMN binding
NPA43_06680	COG2171	N-acyltransferase activity
NPA43_06685	COG1473	amidohydrolase
NPA43_06700	COG0450	alkyl hydroperoxide reductase
NPA43_06705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_06720	COG0746	molybdenum cofactor guanylyltransferase activity
NPA43_06725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NPA43_06730	COG0303	'Molybdopterin
NPA43_06735	COG1763	Mo-molybdopterin cofactor biosynthetic process
NPA43_06740	COG0314	molybdopterin synthase activity
NPA43_06745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NPA43_06760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NPA43_06765	COG1136	(ABC) transporter
NPA43_06770	COG0577	efflux transmembrane transporter activity
NPA43_06775	COG1349	DNA-binding transcription factor activity
NPA43_06780	COG1105	Belongs to the carbohydrate kinase PfkB family
NPA43_06785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_06785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_06785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_06800	COG0488	(ABC) transporter
NPA43_06805	COG2309	aminopeptidase activity
NPA43_06815	COG1077	Cell shape determining protein MreB Mrl
NPA43_06820	COG2002	toxin-antitoxin pair type II binding
NPA43_06825	COG3852	Histidine kinase
NPA43_06830	COG2105	PFAM AIG2 family protein
NPA43_06830	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NPA43_06835	COG0569	domain protein
NPA43_06840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NPA43_06845	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NPA43_06850	COG5503	Protein of unknown function (DUF1447)
NPA43_06855	COG0561	phosphatase activity
NPA43_06860	COG0242	peptide deformylase activity
NPA43_06875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA43_06880	COG0022	dehydrogenase e1 component
NPA43_06885	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA43_06890	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA43_06895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_06905	COG1982	Orn Lys Arg decarboxylase major
NPA43_06910	COG4476	Belongs to the UPF0223 family
NPA43_06915	COG4493	Belongs to the UPF0637 family
NPA43_06925	COG0483	inositol monophosphate 1-phosphatase activity
NPA43_06950	COG1595	DNA-templated transcription, initiation
NPA43_06970	COG1217	gtp-binding protein TYPA
NPA43_06980	COG4896	Protein conserved in bacteria
NPA43_06990	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NPA43_06995	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NPA43_07000	COG2066	Belongs to the glutaminase family
NPA43_07005	COG4838	Belongs to the UPF0358 family
NPA43_07010	COG0772	Belongs to the SEDS family
NPA43_07015	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NPA43_07020	COG0415	Belongs to the DNA photolyase family
NPA43_07025	COG1612	heme a metabolic process
NPA43_07030	COG0109	protoheme IX farnesyltransferase activity
NPA43_07035	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NPA43_07035	COG2010	Cytochrome c
NPA43_07040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NPA43_07045	COG1845	cytochrome c oxidase, subunit III
NPA43_07050	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NPA43_07055	COG3336	cytochrome c oxidase
NPA43_07065	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NPA43_07070	COG2340	Cysteine-rich secretory protein family
NPA43_07090	COG3679	Belongs to the UPF0342 family
NPA43_07095	COG4471	UPF0298 protein
NPA43_07100	COG0742	ribosomal rna small subunit methyltransferase
NPA43_07105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NPA43_07110	COG3314	Sporulation integral membrane protein YlbJ
NPA43_07115	COG1752	Esterase of the alpha-beta hydrolase superfamily
NPA43_07120	COG3480	Lon protease (S16) C-terminal proteolytic domain
NPA43_07130	COG1399	metal-binding, possibly nucleic acid-binding protein
NPA43_07135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NPA43_07145	COG0454	-acetyltransferase
NPA43_07150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NPA43_07155	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NPA43_07160	COG2001	Belongs to the MraZ family
NPA43_07165	COG0275	rRNA processing
NPA43_07170	COG4839	cell division protein FtsL
NPA43_07175	COG0768	penicillin binding
NPA43_07180	COG0768	penicillin binding
NPA43_07190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NPA43_07195	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NPA43_07200	COG0772	Belongs to the SEDS family
NPA43_07205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NPA43_07210	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NPA43_07215	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NPA43_07220	COG3879	Bacterial protein of unknown function (DUF881)
NPA43_07225	COG3879	Bacterial protein of unknown function (DUF881)
NPA43_07230	COG3856	small basic protein
NPA43_07235	COG0849	cell division
NPA43_07240	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NPA43_07245	COG1404	Belongs to the peptidase S8 family
NPA43_07245	COG4412	M6 family metalloprotease domain protein
NPA43_07255	COG1191	sigma factor activity
NPA43_07260	COG1191	sigma factor activity
NPA43_07265	COG2390	Transcriptional regulator
NPA43_07280	COG3730	PTS system glucitol sorbitol-specific
NPA43_07285	COG3732	PTS system glucitol sorbitol-specific
NPA43_07295	COG1119	ATPase activity
NPA43_07300	COG1873	PFAM PRC-barrel domain
NPA43_07305	COG1496	oxidoreductase activity
NPA43_07310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NPA43_07315	COG1799	cell septum assembly
NPA43_07320	COG0762	integral membrane protein
NPA43_07325	COG2302	S4 RNA-binding domain
NPA43_07330	COG3599	regulation of cell shape
NPA43_07335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NPA43_07340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPA43_07345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NPA43_07350	COG0564	pseudouridine synthase activity
NPA43_07355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NPA43_07360	COG2233	PERMEase
NPA43_07365	COG0540	Belongs to the ATCase OTCase family
NPA43_07370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NPA43_07375	COG0505	Belongs to the CarA family
NPA43_07380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NPA43_07385	COG0543	2 iron, 2 sulfur cluster binding
NPA43_07390	COG0167	dihydroorotate dehydrogenase activity
NPA43_07395	COG0284	orotidine-5'-phosphate decarboxylase activity
NPA43_07400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NPA43_07405	COG0175	sulfate reduction
NPA43_07410	COG0306	phosphate transporter
NPA43_07415	COG2046	Belongs to the sulfate adenylyltransferase family
NPA43_07420	COG0529	Catalyzes the synthesis of activated sulfate
NPA43_07425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NPA43_07430	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NPA43_07435	COG1648	precorrin-2 dehydrogenase activity
NPA43_07445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NPA43_07450	COG1561	YicC-like family, N-terminal region
NPA43_07455	COG2052	Domain of unknown function (DUF370)
NPA43_07460	COG0194	GDP metabolic process
NPA43_07465	COG1758	RNA polymerase activity
NPA43_07470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NPA43_07475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NPA43_07480	COG0242	peptide deformylase activity
NPA43_07485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NPA43_07490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NPA43_07490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NPA43_07495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NPA43_07500	COG0631	protein serine/threonine phosphatase activity
NPA43_07505	COG0515	serine threonine protein kinase
NPA43_07505	COG2815	serine threonine protein kinase
NPA43_07510	COG1162	GTPase activity
NPA43_07515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NPA43_07520	COG1564	THIamine pyrophosphokinase
NPA43_07530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NPA43_07535	COG1302	Protein conserved in bacteria
NPA43_07540	COG1461	Dihydroxyacetone kinase
NPA43_07545	COG1760	l-serine dehydratase
NPA43_07550	COG1760	l-serine dehydratase
NPA43_07555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NPA43_07560	COG1349	DNA-binding transcription factor activity
NPA43_07565	COG0416	fatty acid biosynthetic process
NPA43_07570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NPA43_07575	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_07580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA43_07590	COG1196	nuclear chromosome segregation
NPA43_07595	COG0552	protein localization to endoplasmic reticulum
NPA43_07600	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NPA43_07605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NPA43_07610	COG0228	four-way junction DNA binding
NPA43_07615	COG1837	Belongs to the UPF0109 family
NPA43_07625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NPA43_07630	COG0336	Belongs to the RNA methyltransferase TrmD family
NPA43_07635	COG0335	large ribosomal subunit rRNA binding
NPA43_07640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NPA43_07645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NPA43_07655	COG2257	FlhB HrpN YscU SpaS Family
NPA43_07660	COG0045	succinate-CoA ligase (ADP-forming) activity
NPA43_07665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NPA43_07670	COG0758	DNA mediated transformation
NPA43_07675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NPA43_07680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NPA43_07685	COG4974	Belongs to the 'phage' integrase family
NPA43_07690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NPA43_07695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NPA43_07700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NPA43_07705	COG1815	bacterial-type flagellum-dependent cell motility
NPA43_07710	COG1558	bacterial-type flagellum-dependent cell motility
NPA43_07715	COG1677	Flagellar hook-basal body complex protein FliE
NPA43_07720	COG1766	The M ring may be actively involved in energy transduction
NPA43_07725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPA43_07730	COG1317	bacterial-type flagellum organization
NPA43_07735	COG1157	protein secretion by the type III secretion system
NPA43_07740	COG2882	bacterial-type flagellum organization
NPA43_07745	COG3334	PFAM MgtE intracellular
NPA43_07750	COG3144	bacterial-type flagellum assembly
NPA43_07755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NPA43_07760	COG4786	Flagellar basal body rod
NPA43_07765	COG1582	Flagellar protein (FlbD)
NPA43_07770	COG1580	Controls the rotational direction of flagella during chemotaxis
NPA43_07775	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPA43_07780	COG1776	CheC inhibitor of MCP methylation
NPA43_07780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NPA43_07785	COG2201	protein-glutamate methylesterase activity
NPA43_07790	COG3190	flagellar
NPA43_07795	COG1338	Plays a role in the flagellum-specific transport system
NPA43_07800	COG1987	bacterial-type flagellum assembly
NPA43_07805	COG1684	flagellar biosynthetic protein fliR
NPA43_07810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NPA43_07815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NPA43_07820	COG1419	protein localization to endoplasmic reticulum
NPA43_07825	COG0455	bacterial-type flagellum organization
NPA43_07830	COG2201	protein-glutamate methylesterase activity
NPA43_07835	COG0643	Histidine kinase
NPA43_07835	COG2198	Histidine kinase
NPA43_07840	COG0835	chemotaxis
NPA43_07845	COG1776	CheC inhibitor of MCP methylation
NPA43_07855	COG1191	sigma factor activity
NPA43_07870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NPA43_07875	COG0528	UMP kinase activity
NPA43_07880	COG0233	cytoplasmic translational termination
NPA43_07885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NPA43_07890	COG4589	Belongs to the CDS family
NPA43_07895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NPA43_07900	COG0750	zinc metalloprotease
NPA43_07905	COG0442	prolyl-tRNA aminoacylation
NPA43_07910	COG2176	DNA-directed DNA polymerase activity
NPA43_07925	COG3693	PFAM glycoside hydrolase, family 10
NPA43_07935	COG0779	Required for maturation of 30S ribosomal subunits
NPA43_07940	COG0195	Participates in both transcription termination and antitermination
NPA43_07945	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NPA43_07950	COG1358	cellular component organization or biogenesis
NPA43_07955	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NPA43_07960	COG1550	Protein conserved in bacteria
NPA43_07965	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NPA43_07970	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NPA43_07975	COG0196	riboflavin kinase activity
NPA43_07980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NPA43_07985	COG1185	polyribonucleotide nucleotidyltransferase activity
NPA43_07990	COG0726	polysaccharide deacetylase
NPA43_07995	COG0612	Peptidase, M16
NPA43_08010	COG1132	(ABC) transporter
NPA43_08015	COG1132	(ABC) transporter
NPA43_08050	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
NPA43_08060	COG0563	adenylate kinase activity
NPA43_08070	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_08075	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_08080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NPA43_08085	COG1260	myo-inositol-1-phosphate synthase
NPA43_08115	COG1960	acyl-CoA dehydrogenase activity
NPA43_08130	COG0367	asparagine synthase
NPA43_08135	COG1873	PFAM PRC-barrel domain
NPA43_08145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPA43_08150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NPA43_08155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NPA43_08160	COG0527	aspartate kinase activity
NPA43_08170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NPA43_08175	COG0740	serine-type endopeptidase activity
NPA43_08185	COG4980	gas vesicle protein
NPA43_08185	COG1674	ftsk spoiiie
NPA43_08190	COG2188	Transcriptional regulator
NPA43_08195	COG2814	Major facilitator Superfamily
NPA43_08200	COG1033	growth of symbiont in host cell
NPA43_08200	COG2409	Drug exporters of the RND superfamily
NPA43_08205	COG0612	Peptidase, M16
NPA43_08210	COG0612	Peptidase, M16
NPA43_08220	COG1033	growth of symbiont in host cell
NPA43_08220	COG2409	Drug exporters of the RND superfamily
NPA43_08225	COG0300	oxidoreductase activity
NPA43_08240	COG1426	Protein conserved in bacteria
NPA43_08245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NPA43_08250	COG1058	Belongs to the CinA family
NPA43_08250	COG1546	Belongs to the CinA family
NPA43_08255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NPA43_08260	COG1418	mRNA catabolic process
NPA43_08265	COG1692	metallophosphoesterase
NPA43_08270	COG2359	stage V sporulation protein S
NPA43_08275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NPA43_08280	COG1063	alcohol dehydrogenase
NPA43_08285	COG0156	8-amino-7-oxononanoate synthase activity
NPA43_08290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NPA43_08295	COG4550	Control of competence regulator ComK, YlbF/YmcA
NPA43_08305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NPA43_08310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NPA43_08325	COG1329	Transcriptional regulator
NPA43_08330	COG4195	phage-related replication protein
NPA43_08335	COG0457	Tetratricopeptide repeat
NPA43_08340	COG1404	Belongs to the peptidase S8 family
NPA43_08345	COG4195	phage-related replication protein
NPA43_08350	COG1764	response to oxidative stress
NPA43_08355	COG2076	Multidrug Resistance protein
NPA43_08380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NPA43_08385	COG1923	regulation of RNA biosynthetic process
NPA43_08400	COG1780	Probably involved in ribonucleotide reductase function
NPA43_08405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NPA43_08410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NPA43_08415	COG4112	unkown
NPA43_08425	COG0464	growth
NPA43_08430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NPA43_08435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NPA43_08440	COG0789	Transcriptional regulator
NPA43_08445	COG0174	glutamine synthetase
NPA43_08450	COG0582	viral genome integration into host DNA
NPA43_08460	COG0457	Tetratricopeptide repeat
NPA43_08470	COG5444	nuclease activity
NPA43_08515	COG5646	InterPro IPR014922
NPA43_08520	COG0457	Tetratricopeptide repeat
NPA43_08530	COG3619	membrane
NPA43_08535	COG1793	dna ligase
NPA43_08535	COG3285	dna ligase
NPA43_08540	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NPA43_08545	COG4876	unkown
NPA43_08555	COG1959	2 iron, 2 sulfur cluster binding
NPA43_08570	COG0247	lactate metabolic process
NPA43_08575	COG1139	Iron-sulfur cluster binding protein
NPA43_08580	COG1556	Lactate utilization protein
NPA43_08605	COG1309	transcriptional regulator
NPA43_08610	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NPA43_08610	COG2124	cytochrome p450
NPA43_08615	COG3591	Belongs to the peptidase S1B family
NPA43_08620	COG3209	COG3209 Rhs family protein
NPA43_08625	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_08640	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NPA43_08645	COG1388	LysM domain
NPA43_08650	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NPA43_08655	COG4224	UPF0291 protein
NPA43_08660	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NPA43_08670	COG3763	UPF0154 protein
NPA43_08680	COG0785	Cytochrome C biogenesis protein
NPA43_08685	COG4846	Membrane protein involved in cytochrome C biogenesis
NPA43_08695	COG0071	Belongs to the small heat shock protein (HSP20) family
NPA43_08710	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NPA43_08715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_08735	COG0824	Thioesterase
NPA43_08745	COG4841	protein insertion into membrane
NPA43_08750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NPA43_08755	COG1832	CoA-binding protein
NPA43_08760	COG0187	DNA topoisomerase II activity
NPA43_08765	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NPA43_08780	COG0738	Major facilitator superfamily
NPA43_08785	COG0473	3-isopropylmalate dehydrogenase activity
NPA43_08810	COG2323	membrane
NPA43_08820	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NPA43_08830	COG0659	secondary active sulfate transmembrane transporter activity
NPA43_08840	COG0569	domain protein
NPA43_08845	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NPA43_08855	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA43_08860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NPA43_08865	COG0640	Transcriptional regulator
NPA43_08870	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPA43_08900	COG2205	protein histidine kinase activity
NPA43_08905	COG0745	RESPONSE REGULATOR receiver
NPA43_08915	COG3507	Belongs to the glycosyl hydrolase 43 family
NPA43_08920	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_08925	COG1486	melibiose metabolic process
NPA43_08930	COG0395	ABC-type sugar transport system, permease component
NPA43_08935	COG1175	transmembrane transport
NPA43_08940	COG1653	transport
NPA43_08945	COG1609	Transcriptional regulator
NPA43_08950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NPA43_08965	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_08970	COG1846	Transcriptional regulator
NPA43_08975	COG2814	Major facilitator Superfamily
NPA43_08985	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_08985	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_08985	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_08990	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_08990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_08990	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NPA43_08995	COG1105	Belongs to the carbohydrate kinase PfkB family
NPA43_09005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA43_09030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NPA43_09035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPA43_09045	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NPA43_09050	COG1024	Enoyl-CoA hydratase
NPA43_09055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NPA43_09060	COG0511	ligase activity, forming carbon-carbon bonds
NPA43_09065	COG0439	Biotin carboxylase
NPA43_09070	COG0318	PFAM AMP-dependent synthetase and ligase
NPA43_09075	COG1960	acyl-CoA dehydrogenase activity
NPA43_09080	COG1649	PFAM Uncharacterised BCR, COG1649
NPA43_09085	COG2365	Tyrosine phosphatase family
NPA43_09090	COG1349	DNA-binding transcription factor activity
NPA43_09100	COG3835	regulator
NPA43_09105	COG0277	FAD linked oxidase domain protein
NPA43_09110	COG0247	lactate metabolic process
NPA43_09130	COG0166	Belongs to the GPI family
NPA43_09135	COG2246	polysaccharide biosynthetic process
NPA43_09140	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NPA43_09145	COG0586	Pfam SNARE associated Golgi protein
NPA43_09150	COG1587	Uroporphyrinogen-III synthase
NPA43_09160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA43_09170	COG0534	Mate efflux family protein
NPA43_09175	COG2027	D-alanyl-D-alanine carboxypeptidase
NPA43_09180	COG4677	pectinesterase activity
NPA43_09185	COG2323	membrane
NPA43_09190	COG2146	nitrite reductase [NAD(P)H] activity
NPA43_09195	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPA43_09200	COG0243	molybdopterin cofactor binding
NPA43_09205	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NPA43_09210	COG2223	nitrite transmembrane transporter activity
NPA43_09215	COG0493	'glutamate synthase
NPA43_09220	COG0067	glutamate synthase
NPA43_09220	COG0069	glutamate synthase activity
NPA43_09220	COG0070	glutamate synthase
NPA43_09225	COG0583	DNA-binding transcription factor activity
NPA43_09235	COG1132	(ABC) transporter
NPA43_09245	COG0454	-acetyltransferase
NPA43_09250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NPA43_09255	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NPA43_09260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA43_09270	COG0243	molybdopterin cofactor binding
NPA43_09280	COG1070	Carbohydrate kinase
NPA43_09285	COG2115	Belongs to the xylose isomerase family
NPA43_09290	COG1940	carbohydrate kinase activity
NPA43_09300	COG2211	Major facilitator Superfamily
NPA43_09305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA43_09310	COG1994	Peptidase M50
NPA43_09335	COG3708	Transcriptional regulator
NPA43_09340	COG2378	regulation of single-species biofilm formation
NPA43_09350	COG0640	Transcriptional regulator
NPA43_09355	COG0531	amino acid
NPA43_09360	COG0741	lytic transglycosylase activity
NPA43_09365	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NPA43_09370	COG2079	MmgE PrpD family protein
NPA43_09375	COG0372	Belongs to the citrate synthase family
NPA43_09380	COG2322	membrane
NPA43_09390	COG1388	LysM domain
NPA43_09390	COG3584	3D domain protein
NPA43_09395	COG0514	ATP-dependent DNA helicase (RecQ)
NPA43_09405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPA43_09430	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_09435	COG1657	PFAM Prenyltransferase squalene oxidase
NPA43_09440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NPA43_09445	COG0385	Bile acid
NPA43_09450	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA43_09455	COG0567	Dehydrogenase, E1 component
NPA43_09460	COG4548	von Willebrand factor, type A
NPA43_09465	COG0714	Associated with various cellular activities
NPA43_09470	COG2032	superoxide dismutase activity
NPA43_09475	COG0791	NLP P60 protein
NPA43_09475	COG1388	LysM domain
NPA43_09480	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NPA43_09490	COG0534	Mate efflux family protein
NPA43_09495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA43_09500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA43_09510	COG2962	Rard protein
NPA43_09525	COG1733	regulation of RNA biosynthetic process
NPA43_09530	COG0778	Nitroreductase
NPA43_09540	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA43_09545	COG0793	Belongs to the peptidase S41A family
NPA43_09545	COG3409	Peptidoglycan-binding domain 1 protein
NPA43_09550	COG2226	methyltransferase
NPA43_09560	COG1876	peptidase activity
NPA43_09565	COG0813	purine-nucleoside phosphorylase activity
NPA43_09575	COG0671	phosphoesterase, PA-phosphatase related
NPA43_09595	COG4479	Belongs to the UPF0346 family
NPA43_09605	COG1509	lysine 2,3-aminomutase activity
NPA43_09610	COG3829	transcription factor binding
NPA43_09630	COG4641	Protein conserved in bacteria
NPA43_09640	COG1086	Polysaccharide biosynthesis protein
NPA43_09645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NPA43_09650	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NPA43_09655	COG1846	Transcriptional regulator
NPA43_09675	COG4698	Protein conserved in bacteria
NPA43_09680	COG2755	lipolytic protein G-D-S-L family
NPA43_09685	COG1999	signal sequence binding
NPA43_09700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NPA43_09705	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NPA43_09710	COG1272	protein, Hemolysin III
NPA43_09720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NPA43_09725	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NPA43_09730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NPA43_09740	COG2136	Putative SAM-dependent methyltransferase
NPA43_09740	COG2521	methyltransferase
NPA43_09750	COG0129	dihydroxy-acid dehydratase activity
NPA43_09755	COG1413	lyase activity
NPA43_09760	COG1418	mRNA catabolic process
NPA43_09765	COG0386	Belongs to the glutathione peroxidase family
NPA43_09770	COG2759	Belongs to the formate--tetrahydrofolate ligase family
NPA43_09775	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NPA43_09780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NPA43_09790	COG1278	Cold shock
NPA43_09805	COG0328	RNA-DNA hybrid ribonuclease activity
NPA43_09810	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NPA43_09815	COG0328	RNA-DNA hybrid ribonuclease activity
NPA43_09825	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPA43_09835	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NPA43_09845	COG1755	Isoprenylcysteine carboxyl methyltransferase
NPA43_09850	COG3424	synthase
NPA43_09860	COG0726	polysaccharide deacetylase
NPA43_09865	COG2233	PERMEase
NPA43_09870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPA43_09875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NPA43_09880	COG1199	ATP-dependent helicase activity
NPA43_09890	COG0116	Belongs to the methyltransferase superfamily
NPA43_09900	COG3599	regulation of cell shape
NPA43_09905	COG4474	Belongs to the UPF0398 family
NPA43_09915	COG3359	exonuclease
NPA43_09920	COG1111	helicase
NPA43_09920	COG1205	dead DEAH box helicase
NPA43_09925	COG1902	pentaerythritol trinitrate reductase activity
NPA43_09930	COG2190	(PTS) system
NPA43_09935	COG0071	Belongs to the small heat shock protein (HSP20) family
NPA43_09965	COG3331	DNA recombination
NPA43_09970	COG4499	WXG100 protein secretion system (Wss), protein YukC
NPA43_09970	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA43_09980	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NPA43_09985	COG3935	DnaD domain protein
NPA43_09990	COG0017	Asparaginyl-tRNA synthetase
NPA43_09995	COG5353	protein conserved in bacteria
NPA43_10005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NPA43_10005	COG1199	ATP-dependent helicase activity
NPA43_10010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NPA43_10015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NPA43_10020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NPA43_10030	COG0617	tRNA 3'-terminal CCA addition
NPA43_10035	COG0438	transferase activity, transferring glycosyl groups
NPA43_10040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NPA43_10045	COG1803	Methylglyoxal synthase
NPA43_10050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NPA43_10055	COG1694	Mazg nucleotide pyrophosphohydrolase
NPA43_10060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA43_10070	COG4347	Protein of unknown function (DUF1405)
NPA43_10075	COG2010	Cytochrome c
NPA43_10075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NPA43_10080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NPA43_10085	COG0723	plastoquinol--plastocyanin reductase activity
NPA43_10095	COG5582	Belongs to the UPF0302 family
NPA43_10100	COG0457	Tetratricopeptide repeat
NPA43_10105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NPA43_10110	COG0287	Prephenate dehydrogenase
NPA43_10115	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NPA43_10120	COG0159	tryptophan synthase activity
NPA43_10125	COG0133	tryptophan synthase activity
NPA43_10130	COG0135	phosphoribosylanthranilate isomerase activity
NPA43_10135	COG0134	indole-3-glycerol-phosphate synthase activity
NPA43_10150	COG4401	Chorismate mutase type I
NPA43_10155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NPA43_10160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NPA43_10165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NPA43_10170	COG0105	UTP biosynthetic process
NPA43_10175	COG0142	geranyltranstransferase activity
NPA43_10180	COG2226	methyltransferase
NPA43_10185	COG0142	geranyltranstransferase activity
NPA43_10195	COG0302	gtp cyclohydrolase
NPA43_10200	COG0776	regulation of translation
NPA43_10205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NPA43_10220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NPA43_10225	COG1160	GTP binding
NPA43_10250	COG1304	FMN binding
NPA43_10255	COG0539	negative regulation of cytoplasmic translation
NPA43_10260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NPA43_10270	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NPA43_10275	COG2959	enzyme of heme biosynthesis
NPA43_10280	COG3409	Peptidoglycan-binding domain 1 protein
NPA43_10280	COG3773	Cell wall hydrolase
NPA43_10285	COG2339	peptidase activity
NPA43_10290	COG0492	ferredoxin-NADP+ reductase activity
NPA43_10295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NPA43_10300	COG4862	establishment of competence for transformation
NPA43_10305	COG1408	metallophosphoesterase
NPA43_10315	COG1388	LysM domain
NPA43_10320	COG1266	CAAX protease self-immunity
NPA43_10325	COG0514	ATP-dependent DNA helicase (RecQ)
NPA43_10330	COG4955	Helix-turn-helix domain
NPA43_10335	COG1141	Ferredoxin
NPA43_10340	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NPA43_10345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NPA43_10360	COG1595	DNA-templated transcription, initiation
NPA43_10365	COG5002	protein histidine kinase activity
NPA43_10370	COG0745	RESPONSE REGULATOR receiver
NPA43_10375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NPA43_10380	COG1333	cytochrome c biogenesis protein
NPA43_10385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_10390	COG1187	pseudouridine synthase activity
NPA43_10395	COG0700	Nucleoside recognition
NPA43_10400	COG2715	membrane protein required for spore maturation
NPA43_10405	COG1686	Belongs to the peptidase S11 family
NPA43_10415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NPA43_10420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NPA43_10430	COG1547	Domain of unknown function (DUF309)
NPA43_10435	COG0456	acetyltransferase
NPA43_10440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NPA43_10450	COG0307	riboflavin synthase, alpha
NPA43_10465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NPA43_10470	COG4086	secreted protein
NPA43_10475	COG0019	diaminopimelate decarboxylase activity
NPA43_10480	COG0697	spore germination
NPA43_10495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NPA43_10515	COG1191	sigma factor activity
NPA43_10520	COG2172	sigma factor antagonist activity
NPA43_10530	COG1686	Belongs to the peptidase S11 family
NPA43_10535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NPA43_10540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NPA43_10545	COG4974	Belongs to the 'phage' integrase family
NPA43_10555	COG0735	belongs to the Fur family
NPA43_10560	COG1300	Membrane
NPA43_10565	COG1404	Belongs to the peptidase S8 family
NPA43_10575	COG2153	protein acetylation
NPA43_10580	COG1379	DNA repair
NPA43_10585	COG0494	nUDIX hydrolase
NPA43_10590	COG0667	Aldo Keto reductase
NPA43_10600	COG1073	alpha beta
NPA43_10605	COG0457	Tetratricopeptide repeat
NPA43_10615	COG4918	Iron-sulphur cluster biosynthesis
NPA43_10620	COG4305	rare lipoprotein A
NPA43_10625	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NPA43_10625	COG0456	acetyltransferase
NPA43_10630	COG0456	acetyltransferase
NPA43_10640	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NPA43_10650	COG2211	Major facilitator Superfamily
NPA43_10655	COG1072	(Pantothenic acid kinase))
NPA43_10660	COG0446	pyridine nucleotide-disulphide oxidoreductase
NPA43_10665	COG0300	oxidoreductase activity
NPA43_10670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA43_10675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA43_10690	COG4187	Peptidase family M20/M25/M40
NPA43_10695	COG1902	pentaerythritol trinitrate reductase activity
NPA43_10700	COG0596	Alpha beta hydrolase
NPA43_10705	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NPA43_10715	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NPA43_10720	COG2188	Transcriptional regulator
NPA43_10725	COG2723	6-phospho-beta-galactosidase activity
NPA43_10730	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA43_10735	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPA43_10740	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA43_10745	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_10755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NPA43_10760	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NPA43_10775	COG0706	membrane insertase activity
NPA43_10785	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPA43_10790	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NPA43_10795	COG0346	lactoylglutathione lyase activity
NPA43_10805	COG1376	ErfK ybiS ycfS ynhG family protein
NPA43_10810	COG4129	membrane
NPA43_10815	COG1126	abc transporter atp-binding protein
NPA43_10820	COG0765	amino acid transport
NPA43_10825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_10835	COG1597	lipid kinase activity
NPA43_10845	COG0508	dehydrogenase complex catalyzes the overall conversion of
NPA43_10850	COG0022	dehydrogenase e1 component
NPA43_10855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NPA43_10860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NPA43_10865	COG3426	butyrate kinase activity
NPA43_10870	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NPA43_10875	COG0280	phosphate acetyltransferase
NPA43_10880	COG3829	transcription factor binding
NPA43_10880	COG3290	protein histidine kinase activity
NPA43_10890	COG0584	glycerophosphoryl diester phosphodiesterase
NPA43_10895	COG0457	Tetratricopeptide repeat
NPA43_10900	COG0745	RESPONSE REGULATOR receiver
NPA43_10905	COG0750	zinc metalloprotease
NPA43_10910	COG0497	DNA recombination
NPA43_10915	COG1438	arginine binding
NPA43_10920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NPA43_10925	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NPA43_10930	COG0142	geranyltranstransferase activity
NPA43_10935	COG1722	exodeoxyribonuclease VII activity
NPA43_10940	COG1570	exodeoxyribonuclease VII activity
NPA43_10945	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NPA43_10950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NPA43_10955	COG1302	Protein conserved in bacteria
NPA43_10960	COG0439	Biotin carboxylase
NPA43_10965	COG0511	ligase activity, forming carbon-carbon bonds
NPA43_11005	COG3854	ATPases associated with a variety of cellular activities
NPA43_11015	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NPA43_11020	COG0006	proline dipeptidase activity
NPA43_11025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NPA43_11035	COG3872	metal-dependent enzyme
NPA43_11045	COG1752	Esterase of the alpha-beta hydrolase superfamily
NPA43_11050	COG1321	iron dependent repressor
NPA43_11055	COG0095	Lipoate-protein ligase
NPA43_11060	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPA43_11065	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NPA43_11070	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NPA43_11075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NPA43_11080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NPA43_11105	COG0681	Belongs to the peptidase S26 family
NPA43_11140	COG4970	Tfp pilus assembly protein FimT
NPA43_11145	COG4537	Required for transformation and DNA binding
NPA43_11150	COG1459	type II secretion system
NPA43_11155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NPA43_11160	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_11170	COG1393	Belongs to the ArsC family
NPA43_11180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA43_11190	COG0011	TIGRFAM Protein of
NPA43_11195	COG2814	Major facilitator Superfamily
NPA43_11200	COG2866	Carboxypeptidase
NPA43_11205	COG1368	sulfuric ester hydrolase activity
NPA43_11210	COG1940	carbohydrate kinase activity
NPA43_11215	COG4483	Protein conserved in bacteria
NPA43_11220	COG0457	Tetratricopeptide repeat
NPA43_11220	COG0705	Rhomboid family
NPA43_11230	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NPA43_11235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NPA43_11245	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NPA43_11250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NPA43_11255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NPA43_11260	COG0581	inorganic phosphate transmembrane transporter activity
NPA43_11265	COG0573	inorganic phosphate transmembrane transporter activity
NPA43_11270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NPA43_11275	COG0768	penicillin binding
NPA43_11280	COG0477	Major facilitator Superfamily
NPA43_11285	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NPA43_11290	COG2839	Protein conserved in bacteria
NPA43_11295	COG5521	maltodextrose utilization protein MalA
NPA43_11300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NPA43_11305	COG1388	LysM domain
NPA43_11310	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NPA43_11315	COG4709	membrane
NPA43_11320	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NPA43_11325	COG1940	carbohydrate kinase activity
NPA43_11330	COG0735	belongs to the Fur family
NPA43_11335	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NPA43_11340	COG1121	(ABC) transporter
NPA43_11345	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA43_11355	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NPA43_11360	COG0513	Belongs to the DEAD box helicase family
NPA43_11370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NPA43_11375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NPA43_11380	COG2384	SAM-dependent methyltransferase
NPA43_11385	COG2010	Cytochrome c
NPA43_11390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NPA43_11395	COG0358	DNA primase activity
NPA43_11400	COG1671	Belongs to the UPF0178 family
NPA43_11405	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NPA43_11410	COG0517	IMP dehydrogenase activity
NPA43_11415	COG0751	glycine-tRNA ligase activity
NPA43_11420	COG0752	glycyl-tRNA synthetase alpha subunit
NPA43_11425	COG1381	Involved in DNA repair and RecF pathway recombination
NPA43_11435	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NPA43_11440	COG0295	cytidine deaminase activity
NPA43_11445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NPA43_11450	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NPA43_11455	COG1480	7TM receptor with intracellular HD hydrolase
NPA43_11460	COG1702	phosphate starvation-inducible protein PhoH
NPA43_11465	COG0561	phosphatase activity
NPA43_11480	COG4864	UPF0365 protein
NPA43_11485	COG1030	water channel activity
NPA43_11490	COG1610	YqeY-like protein
NPA43_11500	COG1283	sodium-dependent phosphate transmembrane transporter activity
NPA43_11505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NPA43_11510	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NPA43_11515	COG2264	protein methyltransferase activity
NPA43_11520	COG0484	heat shock protein binding
NPA43_11525	COG0443	Heat shock 70 kDa protein
NPA43_11530	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NPA43_11535	COG1420	regulation of RNA biosynthetic process
NPA43_11540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NPA43_11545	COG0481	GTPase activity
NPA43_11555	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA43_11560	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NPA43_11565	COG0268	Binds directly to 16S ribosomal RNA
NPA43_11570	COG1466	dna polymerase III delta subunit
NPA43_11580	COG0658	competence protein
NPA43_11580	COG2333	competence protein COMEC
NPA43_11585	COG2131	deaminase
NPA43_11590	COG1555	photosystem II stabilization
NPA43_11590	COG1596	polysaccharide export
NPA43_11600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NPA43_11605	COG2226	methyltransferase
NPA43_11610	COG0799	negative regulation of ribosome biogenesis
NPA43_11615	COG1713	HD superfamily hydrolase involved in NAD metabolism
NPA43_11620	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NPA43_11625	COG1534	Rna-binding protein
NPA43_11630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NPA43_11635	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NPA43_11640	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NPA43_11655	COG2755	lipolytic protein G-D-S-L family
NPA43_11665	COG0457	Tetratricopeptide repeat
NPA43_11695	COG0726	polysaccharide deacetylase
NPA43_11730	COG2160	L-arabinose isomerase activity
NPA43_11745	COG1609	Transcriptional regulator
NPA43_11755	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NPA43_11760	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NPA43_11765	COG1733	regulation of RNA biosynthetic process
NPA43_11770	COG0657	acetylesterase activity
NPA43_11795	COG2602	Beta-lactamase
NPA43_11800	COG1960	acyl-CoA dehydrogenase activity
NPA43_11805	COG3546	catalase activity
NPA43_11810	COG1063	alcohol dehydrogenase
NPA43_11840	COG1063	alcohol dehydrogenase
NPA43_11845	COG2226	methyltransferase
NPA43_11870	COG0626	cystathionine gamma-synthase activity
NPA43_11875	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA43_11880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NPA43_11885	COG2226	methyltransferase
NPA43_11900	COG0768	penicillin binding
NPA43_11905	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NPA43_11910	COG0572	uridine kinase
NPA43_11915	COG0826	peptidase U32
NPA43_11920	COG0826	peptidase U32
NPA43_11925	COG4122	O-methyltransferase activity
NPA43_11930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NPA43_11935	COG0183	Belongs to the thiolase family
NPA43_11940	COG0318	PFAM AMP-dependent synthetase and ligase
NPA43_11945	COG1268	BioY protein
NPA43_11950	COG3906	Belongs to the UPF0473 family
NPA43_11955	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NPA43_11960	COG4472	Bacterial protein of unknown function (DUF965)
NPA43_11965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NPA43_11970	COG0628	permease
NPA43_11975	COG1126	abc transporter atp-binding protein
NPA43_11980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_11985	COG0765	amino acid transport
NPA43_11990	COG0765	amino acid transport
NPA43_12005	COG3881	PFAM PRC-barrel domain
NPA43_12010	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NPA43_12015	COG0457	Tetratricopeptide repeat
NPA43_12020	COG0482	sulfurtransferase activity
NPA43_12025	COG1104	cysteine desulfurase activity
NPA43_12030	COG1959	2 iron, 2 sulfur cluster binding
NPA43_12035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NPA43_12040	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NPA43_12055	COG0124	histidyl-tRNA synthetase
NPA43_12065	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA43_12065	COG3103	Sh3 type 3 domain protein
NPA43_12065	COG4991	sh3 domain protein
NPA43_12070	COG1490	D-aminoacyl-tRNA deacylase activity
NPA43_12075	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NPA43_12080	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NPA43_12085	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NPA43_12085	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NPA43_12090	COG5416	Lipopolysaccharide assembly protein A domain
NPA43_12095	COG0490	domain, Protein
NPA43_12100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NPA43_12100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NPA43_12110	COG2244	polysaccharide biosynthetic process
NPA43_12115	COG2323	membrane
NPA43_12125	COG1862	Preprotein translocase
NPA43_12130	COG0343	queuine tRNA-ribosyltransferase activity
NPA43_12135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NPA43_12145	COG2255	four-way junction helicase activity
NPA43_12150	COG0632	four-way junction helicase activity
NPA43_12160	COG2112	serine threonine protein kinase
NPA43_12175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NPA43_12185	COG1388	LysM domain
NPA43_12185	COG1388	LysM domain
NPA43_12190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NPA43_12195	COG0157	Belongs to the NadC ModD family
NPA43_12200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NPA43_12205	COG1104	cysteine desulfurase activity
NPA43_12210	COG1827	regulation of RNA biosynthetic process
NPA43_12215	COG0077	Prephenate dehydratase
NPA43_12220	COG4492	Belongs to the UPF0735 family
NPA43_12225	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NPA43_12230	COG3290	protein histidine kinase activity
NPA43_12235	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NPA43_12240	COG2868	ribosomal protein
NPA43_12245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NPA43_12250	COG1994	Peptidase M50
NPA43_12255	COG0739	heme binding
NPA43_12260	COG2894	cell division
NPA43_12265	COG0850	regulation of cytokinetic process
NPA43_12270	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NPA43_12280	COG1077	Cell shape determining protein MreB Mrl
NPA43_12285	COG2003	Belongs to the UPF0758 family
NPA43_12290	COG0424	maF-like protein
NPA43_12305	COG0285	dihydrofolate synthase activity
NPA43_12310	COG0525	valine-tRNA ligase activity
NPA43_12320	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NPA43_12325	COG1388	LysM domain
NPA43_12330	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NPA43_12335	COG0113	porphobilinogen synthase activity
NPA43_12340	COG1587	Uroporphyrinogen-III synthase
NPA43_12345	COG0181	hydroxymethylbilane synthase activity
NPA43_12350	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NPA43_12355	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NPA43_12365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NPA43_12370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NPA43_12375	COG0470	DNA polymerase III
NPA43_12375	COG1067	ATP-dependent peptidase activity
NPA43_12380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NPA43_12385	COG0544	peptidyl-prolyl cis-trans isomerase activity
NPA43_12390	COG0457	Tetratricopeptide repeat
NPA43_12390	COG1477	protein flavinylation
NPA43_12395	COG0066	3-isopropylmalate dehydratase activity
NPA43_12400	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NPA43_12405	COG0473	3-isopropylmalate dehydrogenase activity
NPA43_12410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NPA43_12415	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NPA43_12420	COG0440	acetolactate synthase activity
NPA43_12425	COG0028	Belongs to the TPP enzyme family
NPA43_12430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA43_12435	COG2706	6-phosphogluconolactonase activity
NPA43_12440	COG3339	Conserved Protein
NPA43_12445	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NPA43_12450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NPA43_12455	COG1696	Membrane protein involved in D-alanine export
NPA43_12470	COG0346	lactoylglutathione lyase activity
NPA43_12485	COG0622	Phosphoesterase
NPA43_12490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NPA43_12495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NPA43_12500	COG5401	PFAM Sporulation and spore germination
NPA43_12505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NPA43_12510	COG1846	Transcriptional regulator
NPA43_12515	COG2197	response regulator
NPA43_12520	COG2851	Citrate transporter
NPA43_12525	COG0583	DNA-binding transcription factor activity
NPA43_12530	COG2828	Protein conserved in bacteria
NPA43_12550	COG0824	Thioesterase
NPA43_12555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NPA43_12560	COG1053	succinate dehydrogenase
NPA43_12565	COG2009	succinate dehydrogenase
NPA43_12570	COG1719	4-vinyl reductase, 4VR
NPA43_12575	COG0527	aspartate kinase activity
NPA43_12580	COG0322	excinuclease ABC activity
NPA43_12585	COG3118	belongs to the thioredoxin family
NPA43_12590	COG3534	alpha-L-arabinofuranosidase
NPA43_12595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NPA43_12600	COG2086	electron transfer activity
NPA43_12605	COG1024	Enoyl-CoA hydratase
NPA43_12610	COG1309	transcriptional regulator
NPA43_12615	COG0318	PFAM AMP-dependent synthetase and ligase
NPA43_12625	COG3766	membrane
NPA43_12630	COG1193	negative regulation of DNA recombination
NPA43_12635	COG1796	DNA polymerase
NPA43_12635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NPA43_12640	COG1286	toxin biosynthetic process
NPA43_12645	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NPA43_12650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NPA43_12655	COG0072	phenylalanine-tRNA ligase activity
NPA43_12655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA43_12660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NPA43_12665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NPA43_12675	COG1966	Carbon starvation protein
NPA43_12680	COG1363	Peptidase, m42
NPA43_12690	COG3326	Membrane
NPA43_12695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NPA43_12700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NPA43_12705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NPA43_12710	COG1346	cytolysis
NPA43_12715	COG1380	Effector of murein hydrolase LrgA
NPA43_12720	COG3279	Response regulator of the LytR AlgR family
NPA43_12725	COG3275	phosphorelay sensor kinase activity
NPA43_12730	COG1011	Hydrolase
NPA43_12745	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NPA43_12755	COG0398	Pfam SNARE associated Golgi protein
NPA43_12760	COG1484	DNA-dependent DNA replication
NPA43_12765	COG3611	Membrane attachment protein
NPA43_12770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NPA43_12780	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NPA43_12785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NPA43_12790	COG0237	dephospho-CoA kinase activity
NPA43_12795	COG1971	Probably functions as a manganese efflux pump
NPA43_12800	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NPA43_12805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPA43_12805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NPA43_12810	COG5002	protein histidine kinase activity
NPA43_12815	COG0745	RESPONSE REGULATOR receiver
NPA43_12820	COG0039	L-malate dehydrogenase activity
NPA43_12825	COG0538	isocitrate dehydrogenase activity
NPA43_12830	COG0372	Belongs to the citrate synthase family
NPA43_12835	COG2707	UPF0756 membrane protein
NPA43_12840	COG0628	permease
NPA43_12845	COG3030	protein affecting phage T7 exclusion by the F plasmid
NPA43_12855	COG0205	6-phosphofructokinase activity
NPA43_12860	COG0825	malonyl-CoA metabolic process
NPA43_12865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NPA43_12870	COG0281	malic enzyme
NPA43_12875	COG0587	DNA-directed DNA polymerase activity
NPA43_12895	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NPA43_12905	COG4109	DRTGG domain
NPA43_12910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NPA43_12915	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_12920	COG0165	Argininosuccinate lyase
NPA43_12925	COG0137	argininosuccinate synthase activity
NPA43_12930	COG0521	Mo-molybdopterin cofactor biosynthetic process
NPA43_12935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NPA43_12940	COG0827	DNA restriction-modification system
NPA43_12945	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NPA43_12950	COG3874	Sporulation protein YtfJ
NPA43_12960	COG1714	RDD family
NPA43_12965	COG0616	signal peptide processing
NPA43_12970	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NPA43_12980	COG3239	Fatty acid desaturase
NPA43_12985	COG4585	Histidine kinase
NPA43_12990	COG2197	response regulator
NPA43_12995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_13000	COG0745	RESPONSE REGULATOR receiver
NPA43_13005	COG2205	protein histidine kinase activity
NPA43_13010	COG0772	Belongs to the SEDS family
NPA43_13015	COG1695	Transcriptional regulator
NPA43_13020	COG1136	(ABC) transporter
NPA43_13025	COG0577	efflux transmembrane transporter activity
NPA43_13030	COG0402	S-adenosylhomocysteine deaminase activity
NPA43_13035	COG2249	NAD(P)H dehydrogenase (quinone) activity
NPA43_13045	COG1279	arginine transmembrane transporter activity
NPA43_13050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NPA43_13060	COG0301	tRNA thio-modification
NPA43_13065	COG1104	cysteine desulfurase activity
NPA43_13070	COG1114	Component of the transport system for branched-chain amino acids
NPA43_13075	COG1114	Component of the transport system for branched-chain amino acids
NPA43_13080	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NPA43_13085	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NPA43_13090	COG1309	transcriptional regulator
NPA43_13095	COG1956	GAF domain-containing protein
NPA43_13100	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NPA43_13110	COG1335	isochorismatase
NPA43_13115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NPA43_13135	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NPA43_13140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NPA43_13145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NPA43_13150	COG0454	-acetyltransferase
NPA43_13155	COG0517	IMP dehydrogenase activity
NPA43_13160	COG0123	including yeast histone deacetylase and acetoin utilization protein
NPA43_13165	COG1609	Transcriptional regulator
NPA43_13170	COG1605	Chorismate mutase
NPA43_13170	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NPA43_13175	COG3118	belongs to the thioredoxin family
NPA43_13180	COG4980	gas vesicle protein
NPA43_13185	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NPA43_13190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NPA43_13195	COG1674	ftsk spoiiie
NPA43_13200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NPA43_13205	COG4848	Belongs to the UPF0354 family
NPA43_13210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_13225	COG1363	Peptidase, m42
NPA43_13230	COG5584	Small secreted protein
NPA43_13235	COG0281	malic enzyme
NPA43_13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NPA43_13245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NPA43_13255	COG0510	thiamine kinase activity
NPA43_13260	COG1597	lipid kinase activity
NPA43_13270	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NPA43_13275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NPA43_13280	COG3340	Belongs to the peptidase S51 family
NPA43_13285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NPA43_13290	COG2252	PERMEase
NPA43_13295	COG1349	DNA-binding transcription factor activity
NPA43_13300	COG1187	pseudouridine synthase activity
NPA43_13305	COG2244	polysaccharide biosynthetic process
NPA43_13310	COG2081	HI0933 family
NPA43_13320	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NPA43_13340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NPA43_13345	COG5578	integral membrane protein
NPA43_13350	COG0673	inositol 2-dehydrogenase activity
NPA43_13355	COG1653	transport
NPA43_13360	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NPA43_13365	COG4209	transmembrane transport
NPA43_13370	COG2207	Transcriptional regulator
NPA43_13375	COG1653	transport
NPA43_13380	COG0395	ABC-type sugar transport system, permease component
NPA43_13385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA43_13390	COG1073	alpha beta
NPA43_13395	COG0495	leucyl-tRNA aminoacylation
NPA43_13405	COG2202	Pas domain
NPA43_13405	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_13410	COG2433	Pfam Transposase IS66
NPA43_13415	COG0577	efflux transmembrane transporter activity
NPA43_13420	COG1136	(ABC) transporter
NPA43_13430	COG1131	(ABC) transporter
NPA43_13435	COG1725	Transcriptional regulator
NPA43_13450	COG1242	4 iron, 4 sulfur cluster binding
NPA43_13455	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NPA43_13465	COG2267	carboxylic ester hydrolase activity
NPA43_13470	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NPA43_13475	COG0367	asparagine synthase
NPA43_13480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NPA43_13485	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NPA43_13495	COG1506	peptidase
NPA43_13500	COG1233	COG1233 Phytoene dehydrogenase and related
NPA43_13520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NPA43_13525	COG1116	anion transmembrane transporter activity
NPA43_13530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NPA43_13535	COG0494	nUDIX hydrolase
NPA43_13540	COG2310	stress, protein
NPA43_13555	COG4824	toxin secretion phage lysis holin
NPA43_13565	COG0783	Belongs to the Dps family
NPA43_13580	COG1854	S-ribosylhomocysteine lyase activity
NPA43_13585	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NPA43_13590	COG0288	reversible hydration of carbon dioxide
NPA43_13595	COG0803	Belongs to the bacterial solute-binding protein 9 family
NPA43_13595	COG3443	Belongs to the bacterial solute-binding protein 9 family
NPA43_13605	COG1271	oxidase subunit
NPA43_13610	COG1294	oxidase, subunit
NPA43_13625	COG4948	Mandelate Racemase Muconate Lactonizing
NPA43_13630	COG0318	PFAM AMP-dependent synthetase and ligase
NPA43_13635	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NPA43_13640	COG0596	Alpha beta hydrolase
NPA43_13645	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NPA43_13650	COG1169	isochorismate synthase
NPA43_13655	COG1575	Belongs to the MenA family. Type 1 subfamily
NPA43_13660	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NPA43_13790	COG3859	Proton-coupled thiamine transporter YuaJ
NPA43_13800	COG1247	-acetyltransferase
NPA43_13805	COG2268	Band 7 protein
NPA43_13810	COG1585	Membrane protein implicated in regulation of membrane protease activity
NPA43_13815	COG2318	DinB family
NPA43_13820	COG1454	alcohol dehydrogenase
NPA43_13825	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_13830	COG1510	regulation of RNA biosynthetic process
NPA43_13845	COG3409	Peptidoglycan-binding domain 1 protein
NPA43_13845	COG5632	N-Acetylmuramoyl-L-alanine amidase
NPA43_13890	COG3778	Protein conserved in bacteria
NPA43_13895	COG3299	homolog of phage Mu protein gp47
NPA43_13900	COG3628	GPW Gp25 family protein
NPA43_13910	COG4193	domain, Protein
NPA43_13915	COG1652	LysM domain
NPA43_13920	COG3953	SLT domain
NPA43_13920	COG5280	Phage tail tape measure protein TP901
NPA43_13920	COG3953	SLT domain
NPA43_13920	COG5280	Phage tail tape measure protein TP901
NPA43_13975	COG4653	Phage capsid family
NPA43_13980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NPA43_13985	COG5518	Phage portal protein
NPA43_13990	COG1783	phage Terminase large subunit
NPA43_13995	COG5484	DNA packaging
NPA43_14000	COG1595	DNA-templated transcription, initiation
NPA43_14010	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
NPA43_14025	COG1396	sequence-specific DNA binding
NPA43_14030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NPA43_14040	COG1968	undecaprenyl-diphosphatase activity
NPA43_14045	COG0628	permease
NPA43_14055	COG0673	inositol 2-dehydrogenase activity
NPA43_14060	COG0693	protein deglycase activity
NPA43_14065	COG0840	transmembrane signaling receptor activity
NPA43_14070	COG0840	transmembrane signaling receptor activity
NPA43_14075	COG0840	transmembrane signaling receptor activity
NPA43_14080	COG0840	transmembrane signaling receptor activity
NPA43_14095	COG2070	2-Nitropropane dioxygenase
NPA43_14100	COG0432	Pfam Uncharacterised protein family UPF0047
NPA43_14105	COG1253	flavin adenine dinucleotide binding
NPA43_14110	COG2738	Putative neutral zinc metallopeptidase
NPA43_14120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NPA43_14135	COG0166	Belongs to the GPI family
NPA43_14140	COG1979	alcohol dehydrogenase
NPA43_14145	COG1979	alcohol dehydrogenase
NPA43_14150	COG2155	Conserved Protein
NPA43_14155	COG1098	S1 RNA binding domain
NPA43_14160	COG0436	Aminotransferase
NPA43_14165	COG1522	sequence-specific DNA binding
NPA43_14170	COG2267	carboxylic ester hydrolase activity
NPA43_14180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NPA43_14185	COG2205	protein histidine kinase activity
NPA43_14200	COG5018	Exonuclease
NPA43_14205	COG2814	Major facilitator Superfamily
NPA43_14210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA43_14215	COG3011	Protein conserved in bacteria
NPA43_14225	COG3290	protein histidine kinase activity
NPA43_14230	COG4565	transcriptional regulatory protein
NPA43_14235	COG1744	ABC transporter substrate-binding protein PnrA-like
NPA43_14240	COG3845	ABC transporter
NPA43_14245	COG4603	Belongs to the binding-protein-dependent transport system permease family
NPA43_14250	COG1079	Belongs to the binding-protein-dependent transport system permease family
NPA43_14255	COG3493	citrate carrier protein
NPA43_14265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NPA43_14265	COG2111	Na H antiporter
NPA43_14270	COG2111	Na H antiporter
NPA43_14275	COG1006	Multisubunit Na H antiporter MnhC subunit
NPA43_14280	COG0651	ATP synthesis coupled electron transport
NPA43_14285	COG1863	multisubunit Na H antiporter MnhE subunit
NPA43_14290	COG2212	antiporter activity
NPA43_14295	COG1320	monovalent cation:proton antiporter activity
NPA43_14300	COG2050	protein possibly involved in aromatic compounds catabolism
NPA43_14305	COG2197	response regulator
NPA43_14310	COG4585	Histidine kinase
NPA43_14320	COG0142	geranyltranstransferase activity
NPA43_14335	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NPA43_14340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NPA43_14345	COG1335	isochorismatase
NPA43_14350	COG5506	Protein of unknown function (DUF1694)
NPA43_14370	COG0628	permease
NPA43_14385	COG1418	mRNA catabolic process
NPA43_14390	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_14400	COG1511	domain protein
NPA43_14405	COG0433	COG0433 Predicted ATPase
NPA43_14405	COG1674	ftsk spoiiie
NPA43_14410	COG4499	WXG100 protein secretion system (Wss), protein YukC
NPA43_14415	COG5417	Belongs to the EsaB family
NPA43_14420	COG4842	Belongs to the WXG100 family
NPA43_14425	COG2508	Transcriptional regulator
NPA43_14425	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NPA43_14430	COG0686	Belongs to the AlaDH PNT family
NPA43_14435	COG1268	BioY protein
NPA43_14440	COG2056	Na+-H+ antiporter family
NPA43_14445	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NPA43_14450	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NPA43_14455	COG3584	3D domain protein
NPA43_14470	COG1252	NADH dehydrogenase
NPA43_14475	COG0492	ferredoxin-NADP+ reductase activity
NPA43_14485	COG0789	Transcriptional regulator
NPA43_14490	COG5504	Zn-dependent protease
NPA43_14495	COG0316	Belongs to the HesB IscA family
NPA43_14500	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NPA43_14505	COG4844	belongs to the
NPA43_14510	COG1252	NADH dehydrogenase
NPA43_14520	COG4837	Protein of unknown function (DUF1462)
NPA43_14530	COG0823	Involved in the tonB-independent uptake of proteins
NPA43_14530	COG4946	Tricorn protease homolog
NPA43_14530	COG1506	peptidase
NPA43_14535	COG0083	homoserine kinase activity
NPA43_14540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NPA43_14545	COG0460	homoserine dehydrogenase
NPA43_14550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPA43_14555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NPA43_14560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NPA43_14565	COG0647	UMP catabolic process
NPA43_14570	COG2445	Protein of unknown function DUF86
NPA43_14575	COG4470	Protein conserved in bacteria
NPA43_14585	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NPA43_14590	COG0739	heme binding
NPA43_14600	COG3377	Domain of unknown function (DUF1805)
NPA43_14605	COG0737	Belongs to the 5'-nucleotidase family
NPA43_14610	COG1801	Protein of unknown function DUF72
NPA43_14615	COG2508	Transcriptional regulator
NPA43_14620	COG2814	Major facilitator Superfamily
NPA43_14625	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NPA43_14630	COG2356	endonuclease I
NPA43_14640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_14645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_14650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_14665	COG5002	protein histidine kinase activity
NPA43_14665	COG0642	Histidine kinase
NPA43_14670	COG0745	RESPONSE REGULATOR receiver
NPA43_14675	COG2311	Membrane
NPA43_14685	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NPA43_14705	COG0719	Fe-S assembly protein
NPA43_14710	COG0822	iron-sulfur transferase activity
NPA43_14715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NPA43_14720	COG0719	Fe-S assembly protein
NPA43_14725	COG0396	ATPase activity
NPA43_14735	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NPA43_14740	COG1464	Belongs to the NlpA lipoprotein family
NPA43_14745	COG2011	ABC-type metal ion transport system permease component
NPA43_14750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NPA43_14760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NPA43_14765	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NPA43_14775	COG0509	glycine decarboxylation via glycine cleavage system
NPA43_14780	COG1393	Belongs to the ArsC family
NPA43_14785	COG1960	acyl-CoA dehydrogenase activity
NPA43_14790	COG0183	Belongs to the thiolase family
NPA43_14795	COG1250	3-hydroxyacyl-CoA dehydrogenase
NPA43_14795	COG1024	Enoyl-CoA hydratase
NPA43_14810	COG5577	PFAM Coat F domain
NPA43_14820	COG1120	ATPase activity
NPA43_14830	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_14835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA43_14840	COG0745	RESPONSE REGULATOR receiver
NPA43_14845	COG2205	protein histidine kinase activity
NPA43_14845	COG2770	Histidine kinase
NPA43_14855	COG1309	transcriptional regulator
NPA43_14860	COG0114	fumarate hydratase activity
NPA43_14870	COG0697	spore germination
NPA43_14875	COG0814	amino acid
NPA43_14890	COG2197	response regulator
NPA43_14895	COG4585	Histidine kinase
NPA43_14900	COG4758	membrane
NPA43_14910	COG1842	Phage shock protein A
NPA43_14915	COG4758	membrane
NPA43_14920	COG2096	Adenosyltransferase
NPA43_14925	COG1120	ATPase activity
NPA43_14930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_14935	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_14945	COG2721	sulfolactate sulfo-lyase activity
NPA43_14950	COG0246	Mannitol dehydrogenase
NPA43_14955	COG1609	Transcriptional regulator
NPA43_14960	COG1904	glucuronate isomerase
NPA43_14965	COG2205	protein histidine kinase activity
NPA43_14970	COG0745	RESPONSE REGULATOR receiver
NPA43_14975	COG1120	ATPase activity
NPA43_14980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_14985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_14990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_14995	COG0531	amino acid
NPA43_15010	COG1988	membrane-bound metal-dependent
NPA43_15015	COG1368	sulfuric ester hydrolase activity
NPA43_15020	COG0725	ABC transporter, periplasmic molybdate-binding protein
NPA43_15025	COG4149	molybdate abc transporter
NPA43_15030	COG0656	L-ascorbic acid biosynthetic process
NPA43_15035	COG1940	carbohydrate kinase activity
NPA43_15040	COG0025	NhaP-type Na H and K H
NPA43_15045	COG2860	membrane
NPA43_15050	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NPA43_15055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NPA43_15060	COG2217	Heavy metal translocating P-type atpase
NPA43_15065	COG1121	(ABC) transporter
NPA43_15070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NPA43_15075	COG0803	Belongs to the bacterial solute-binding protein 9 family
NPA43_15085	COG3226	Transcriptional regulator
NPA43_15090	COG0784	Response regulator, receiver
NPA43_15095	COG4191	Histidine kinase
NPA43_15100	COG1027	Aspartate ammonia-lyase
NPA43_15115	COG2217	Heavy metal translocating P-type atpase
NPA43_15120	COG2608	mercury ion transmembrane transporter activity
NPA43_15125	COG1937	Protein conserved in bacteria
NPA43_15160	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NPA43_15165	COG0557	exoribonuclease II activity
NPA43_15170	COG1647	Serine aminopeptidase, S33
NPA43_15175	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NPA43_15180	COG2002	toxin-antitoxin pair type II binding
NPA43_15185	COG1476	TRANSCRIPTIONal
NPA43_15190	COG1396	sequence-specific DNA binding
NPA43_15195	COG1396	sequence-specific DNA binding
NPA43_15200	COG1733	regulation of RNA biosynthetic process
NPA43_15205	COG1174	glycine betaine transport
NPA43_15210	COG1732	Glycine betaine
NPA43_15215	COG1174	glycine betaine transport
NPA43_15220	COG0517	IMP dehydrogenase activity
NPA43_15220	COG1125	glycine betaine transport
NPA43_15225	COG1510	regulation of RNA biosynthetic process
NPA43_15230	COG2095	MarC family integral membrane protein
NPA43_15240	COG0456	acetyltransferase
NPA43_15260	COG1131	(ABC) transporter
NPA43_15270	COG0148	phosphopyruvate hydratase activity
NPA43_15275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NPA43_15280	COG0149	triose-phosphate isomerase activity
NPA43_15285	COG0126	phosphoglycerate kinase activity
NPA43_15290	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NPA43_15295	COG2390	Transcriptional regulator
NPA43_15300	COG0833	amino acid
NPA43_15305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NPA43_15310	COG3829	transcription factor binding
NPA43_15315	COG2186	Transcriptional regulator
NPA43_15320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NPA43_15330	COG0534	Mate efflux family protein
NPA43_15335	COG4608	Belongs to the ABC transporter superfamily
NPA43_15340	COG0444	Belongs to the ABC transporter superfamily
NPA43_15345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NPA43_15350	COG0601	transmembrane transport
NPA43_15355	COG0747	negative chemotaxis
NPA43_15360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA43_15365	COG0110	maltose O-acetyltransferase activity
NPA43_15370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NPA43_15375	COG2244	polysaccharide biosynthetic process
NPA43_15380	COG5039	Polysaccharide pyruvyl transferase
NPA43_15385	COG1216	Glycosyl transferase, family 2
NPA43_15395	COG0438	transferase activity, transferring glycosyl groups
NPA43_15400	COG1215	transferase activity, transferring glycosyl groups
NPA43_15405	COG0438	transferase activity, transferring glycosyl groups
NPA43_15410	COG1086	Polysaccharide biosynthesis protein
NPA43_15415	COG0489	protein tyrosine kinase activity
NPA43_15420	COG3944	biosynthesis protein
NPA43_15425	COG1396	sequence-specific DNA binding
NPA43_15435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_15440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_15445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_15450	COG0726	polysaccharide deacetylase
NPA43_15455	COG0488	(ABC) transporter
NPA43_15460	COG1124	(ABC) transporter
NPA43_15475	COG0601	transmembrane transport
NPA43_15480	COG0747	negative chemotaxis
NPA43_15485	COG1819	glycosyl
NPA43_15500	COG0740	serine-type endopeptidase activity
NPA43_15510	COG1694	Mazg nucleotide pyrophosphohydrolase
NPA43_15520	COG0288	reversible hydration of carbon dioxide
NPA43_15525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPA43_15535	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NPA43_15540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_15545	COG1481	regulation of sporulation
NPA43_15550	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NPA43_15555	COG1660	Displays ATPase and GTPase activities
NPA43_15560	COG1051	belongs to the nudix hydrolase family
NPA43_15565	COG0492	ferredoxin-NADP+ reductase activity
NPA43_15570	COG3883	PFAM NLP P60 protein
NPA43_15570	COG0791	NLP P60 protein
NPA43_15575	COG0457	Tetratricopeptide repeat
NPA43_15580	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NPA43_15580	COG0140	phosphoribosyl-ATP diphosphatase activity
NPA43_15585	COG0107	imidazoleglycerol-phosphate synthase activity
NPA43_15590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NPA43_15595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NPA43_15600	COG0131	Imidazoleglycerol-phosphate dehydratase
NPA43_15605	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NPA43_15610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NPA43_15615	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NPA43_15620	COG4990	cell redox homeostasis
NPA43_15625	COG2910	NAD(P)H-binding
NPA43_15630	COG1959	2 iron, 2 sulfur cluster binding
NPA43_15635	COG0110	maltose O-acetyltransferase activity
NPA43_15640	COG0546	phosphoglycolate phosphatase activity
NPA43_15645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NPA43_15650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NPA43_15655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NPA43_15660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NPA43_15665	COG0363	glucosamine-6-phosphate deaminase activity
NPA43_15670	COG2188	Transcriptional regulator
NPA43_15675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NPA43_15680	COG1950	PFAM Membrane protein of
NPA43_15685	COG1983	PspC domain protein
NPA43_15690	COG3595	metallopeptidase activity
NPA43_15705	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NPA43_15715	COG4897	Protein conserved in bacteria
NPA43_15720	COG0574	Belongs to the PEP-utilizing enzyme family
NPA43_15720	COG3848	Pyruvate phosphate dikinase
NPA43_15725	COG1309	transcriptional regulator
NPA43_15730	COG2814	Major facilitator Superfamily
NPA43_15740	COG0745	RESPONSE REGULATOR receiver
NPA43_15745	COG5002	protein histidine kinase activity
NPA43_15750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NPA43_15755	COG0463	Glycosyl transferase, family 2
NPA43_15760	COG1113	amino acid transport
NPA43_15765	COG0778	Nitroreductase
NPA43_15770	COG1733	regulation of RNA biosynthetic process
NPA43_15775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA43_15785	COG0793	Belongs to the peptidase S41A family
NPA43_15785	COG3409	Peptidoglycan-binding domain 1 protein
NPA43_15790	COG0730	response to heat
NPA43_15795	COG3883	PFAM NLP P60 protein
NPA43_15795	COG0791	NLP P60 protein
NPA43_15800	COG2177	Part of the ABC transporter FtsEX involved in
NPA43_15805	COG2884	Cell division ATP-binding protein ftsE
NPA43_15810	COG2010	Cytochrome c
NPA43_15815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NPA43_15835	COG0653	protein targeting
NPA43_15840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NPA43_15845	COG0840	transmembrane signaling receptor activity
NPA43_15860	COG1516	flagellar protein fliS
NPA43_15865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NPA43_15870	COG1334	flagellar protein FlaG
NPA43_15875	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NPA43_15880	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NPA43_15890	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NPA43_15895	COG1256	bacterial-type flagellum assembly
NPA43_15895	COG4786	Flagellar basal body rod
NPA43_15900	COG3418	PFAM FlgN family protein
NPA43_15915	COG1040	competence protein
NPA43_15930	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NPA43_15935	COG1307	EDD domain protein, DegV family
NPA43_15940	COG2197	response regulator
NPA43_15945	COG4585	Histidine kinase
NPA43_15950	COG1739	Uncharacterized protein family UPF0029
NPA43_15955	COG1316	TRANSCRIPTIONal
NPA43_15960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NPA43_15965	COG0438	transferase activity, transferring glycosyl groups
NPA43_15970	COG1215	transferase activity, transferring glycosyl groups
NPA43_15975	COG3206	protein involved in exopolysaccharide biosynthesis
NPA43_15980	COG3307	-O-antigen
NPA43_15985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NPA43_15990	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NPA43_15995	COG0297	glycogen (starch) synthase activity
NPA43_15995	COG0438	transferase activity, transferring glycosyl groups
NPA43_16000	COG2244	polysaccharide biosynthetic process
NPA43_16015	COG0860	N-Acetylmuramoyl-L-alanine amidase
NPA43_16015	COG2247	cell wall binding repeat
NPA43_16020	COG2247	cell wall binding repeat
NPA43_16020	COG2385	sporulation resulting in formation of a cellular spore
NPA43_16030	COG1316	TRANSCRIPTIONal
NPA43_16035	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NPA43_16040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NPA43_16045	COG1134	teichoic acid transport
NPA43_16050	COG1682	transport, permease protein
NPA43_16055	COG1216	Glycosyl transferase, family 2
NPA43_16065	COG1181	Belongs to the D-alanine--D-alanine ligase family
NPA43_16070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA43_16085	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA43_16090	COG0438	transferase activity, transferring glycosyl groups
NPA43_16095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NPA43_16100	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NPA43_16105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA43_16110	COG4193	domain, Protein
NPA43_16115	COG1482	cell wall glycoprotein biosynthetic process
NPA43_16125	COG1175	transmembrane transport
NPA43_16130	COG1653	transport
NPA43_16135	COG2197	response regulator
NPA43_16140	COG2972	Histidine kinase
NPA43_16150	COG0454	-acetyltransferase
NPA43_16155	COG0800	Aldolase
NPA43_16160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA43_16165	COG1609	Transcriptional regulator
NPA43_16170	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NPA43_16175	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_16180	COG0697	spore germination
NPA43_16185	COG0814	amino acid
NPA43_16200	COG2814	Major facilitator Superfamily
NPA43_16205	COG1316	TRANSCRIPTIONal
NPA43_16210	COG0561	phosphatase activity
NPA43_16215	COG0791	NLP P60 protein
NPA43_16225	COG2843	Capsule synthesis protein
NPA43_16235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NPA43_16240	COG0697	spore germination
NPA43_16255	COG1609	Transcriptional regulator
NPA43_16260	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NPA43_16265	COG1869	D-ribose catabolic process
NPA43_16270	COG1129	ABC transporter
NPA43_16275	COG1172	Belongs to the binding-protein-dependent transport system permease family
NPA43_16280	COG1879	ABC-type sugar transport system periplasmic component
NPA43_16285	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NPA43_16290	COG0583	DNA-binding transcription factor activity
NPA43_16295	COG0028	Belongs to the TPP enzyme family
NPA43_16300	COG3527	Alpha-acetolactate decarboxylase
NPA43_16305	COG1522	sequence-specific DNA binding
NPA43_16310	COG2059	Chromate
NPA43_16315	COG2059	Chromate
NPA43_16320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NPA43_16330	COG4715	Zinc finger, swim domain protein
NPA43_16335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NPA43_16340	COG2202	Pas domain
NPA43_16340	COG1366	Belongs to the anti-sigma-factor antagonist family
NPA43_16345	COG0561	phosphatase activity
NPA43_16360	COG1970	mechanosensitive ion channel activity
NPA43_16365	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NPA43_16370	COG0457	Tetratricopeptide repeat
NPA43_16375	COG4786	Flagellar basal body rod
NPA43_16380	COG4786	Flagellar basal body rod
NPA43_16385	COG1077	Cell shape determining protein MreB Mrl
NPA43_16390	COG1609	Transcriptional regulator
NPA43_16395	COG1846	Transcriptional regulator
NPA43_16400	COG2814	Major facilitator Superfamily
NPA43_16405	COG0671	phosphoesterase, PA-phosphatase related
NPA43_16410	COG0477	Major facilitator Superfamily
NPA43_16415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_16420	COG0765	amino acid transport
NPA43_16425	COG1126	abc transporter atp-binding protein
NPA43_16430	COG0004	ammonium transporteR
NPA43_16435	COG0347	Belongs to the P(II) protein family
NPA43_16440	COG0739	heme binding
NPA43_16445	COG1247	-acetyltransferase
NPA43_16480	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NPA43_16485	COG0523	cobalamin synthesis protein
NPA43_16490	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NPA43_16495	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NPA43_16500	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NPA43_16505	COG2223	nitrite transmembrane transporter activity
NPA43_16510	COG0243	molybdopterin cofactor binding
NPA43_16515	COG2304	oxidoreductase activity
NPA43_16520	COG2304	oxidoreductase activity
NPA43_16525	COG2385	sporulation resulting in formation of a cellular spore
NPA43_16530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NPA43_16540	COG4836	Membrane
NPA43_16550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NPA43_16555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NPA43_16560	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NPA43_16565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NPA43_16570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NPA43_16575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NPA43_16580	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NPA43_16585	COG0356	it plays a direct role in the translocation of protons across the membrane
NPA43_16595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NPA43_16600	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NPA43_16605	COG4475	Protein of unknown function (DUF436)
NPA43_16610	COG0698	ribose 5-phosphate isomerase
NPA43_16615	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NPA43_16620	COG1971	Probably functions as a manganese efflux pump
NPA43_16625	COG0009	L-threonylcarbamoyladenylate synthase
NPA43_16630	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NPA43_16645	COG2890	protein-(glutamine-N5) methyltransferase activity
NPA43_16650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NPA43_16655	COG0789	Transcriptional regulator
NPA43_16660	COG0679	Auxin Efflux Carrier
NPA43_16665	COG0281	malic enzyme
NPA43_16670	COG1435	thymidine kinase activity
NPA43_16675	COG0254	rRNA binding
NPA43_16680	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NPA43_16685	COG1494	fructose-1,6-bisphosphatase
NPA43_16690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NPA43_16695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NPA43_16700	COG0191	fructose-bisphosphate aldolase activity
NPA43_16705	COG2204	response regulator
NPA43_16710	COG4821	SIS domain
NPA43_16715	COG0504	CTP synthase activity
NPA43_16720	COG3343	RNA polymerase activity
NPA43_16750	COG1960	acyl-CoA dehydrogenase activity
NPA43_16755	COG1960	acyl-CoA dehydrogenase activity
NPA43_16760	COG1250	3-hydroxyacyl-CoA dehydrogenase
NPA43_16765	COG0183	Belongs to the thiolase family
NPA43_16770	COG0247	lactate metabolic process
NPA43_16770	COG2181	nitrate reductase activity
NPA43_16775	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA43_16780	COG4294	response to UV
NPA43_16795	COG1132	(ABC) transporter
NPA43_16800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NPA43_16805	COG1619	proteins homologs of microcin C7 resistance protein MccF
NPA43_16810	COG0018	arginyl-trna synthetase
NPA43_16815	COG4506	Protein conserved in bacteria
NPA43_16825	COG0010	Belongs to the arginase family
NPA43_16830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NPA43_16835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NPA43_16845	COG1994	Peptidase M50
NPA43_16850	COG1942	4-Oxalocrotonate Tautomerase
NPA43_16860	COG3465	dGTPase activity
NPA43_16865	COG1078	dGTPase activity
NPA43_16870	COG4844	belongs to the
NPA43_16935	COG0280	phosphate acetyltransferase
NPA43_16945	COG1073	alpha beta
NPA43_16950	COG1522	sequence-specific DNA binding
NPA43_16955	COG2814	Major facilitator Superfamily
NPA43_16960	COG0077	Prephenate dehydratase
NPA43_16970	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_16975	COG0151	Belongs to the GarS family
NPA43_16980	COG0436	Aminotransferase
NPA43_16985	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_16990	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NPA43_16995	COG1091	dTDP-4-dehydrorhamnose reductase activity
NPA43_17000	COG1088	dTDP-glucose 4,6-dehydratase activity
NPA43_17005	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NPA43_17010	COG3980	spore coat polysaccharide biosynthesis protein
NPA43_17015	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NPA43_17020	COG2089	acid synthase
NPA43_17025	COG0456	acetyltransferase
NPA43_17030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NPA43_17035	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NPA43_17040	COG0463	Glycosyl transferase, family 2
NPA43_17060	COG2363	Small membrane protein
NPA43_17065	COG2233	PERMEase
NPA43_17075	COG1012	belongs to the aldehyde dehydrogenase family
NPA43_17080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NPA43_17085	COG1216	Glycosyl transferase, family 2
NPA43_17095	COG0351	phosphomethylpyrimidine kinase
NPA43_17105	COG1621	beta-fructofuranosidase activity
NPA43_17110	COG1263	PTS System
NPA43_17110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_17115	COG3711	transcriptional antiterminator
NPA43_17125	COG1404	Belongs to the peptidase S8 family
NPA43_17130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA43_17135	COG0778	Nitroreductase
NPA43_17140	COG0772	Belongs to the SEDS family
NPA43_17150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NPA43_17155	COG1845	cytochrome c oxidase, subunit III
NPA43_17160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NPA43_17165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NPA43_17175	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NPA43_17180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NPA43_17185	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NPA43_17200	COG2246	polysaccharide biosynthetic process
NPA43_17220	COG3162	membrane
NPA43_17225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NPA43_17240	COG0352	thiamine-phosphate diphosphorylase activity
NPA43_17245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NPA43_17250	COG0583	DNA-binding transcription factor activity
NPA43_17255	COG1380	Effector of murein hydrolase LrgA
NPA43_17260	COG1346	cytolysis
NPA43_17265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NPA43_17270	COG0346	lactoylglutathione lyase activity
NPA43_17280	COG0765	amino acid transport
NPA43_17285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NPA43_17290	COG0457	Tetratricopeptide repeat
NPA43_17300	COG2357	RelA SpoT domain protein
NPA43_17305	COG1172	Belongs to the binding-protein-dependent transport system permease family
NPA43_17310	COG1129	ABC transporter
NPA43_17335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NPA43_17340	COG0179	Fumarylacetoacetate (FAA) hydrolase
NPA43_17365	COG3290	protein histidine kinase activity
NPA43_17365	COG3829	transcription factor binding
NPA43_17385	COG0477	Major facilitator Superfamily
NPA43_17405	COG2267	carboxylic ester hydrolase activity
NPA43_17410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NPA43_17415	COG0673	inositol 2-dehydrogenase activity
NPA43_17420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NPA43_17430	COG1486	melibiose metabolic process
NPA43_17435	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPA43_17440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA43_17445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NPA43_17450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_17450	COG3711	transcriptional antiterminator
NPA43_17470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NPA43_17485	COG1595	DNA-templated transcription, initiation
NPA43_17495	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NPA43_17500	COG4988	ABC transporter
NPA43_17505	COG1294	oxidase, subunit
NPA43_17510	COG1271	oxidase subunit
NPA43_17525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NPA43_17535	COG4509	Sortase family
NPA43_17560	COG5386	Cell surface protein
NPA43_17565	COG5386	Cell surface protein
NPA43_17570	COG1733	regulation of RNA biosynthetic process
NPA43_17575	COG2514	catechol 2,3-dioxygenase activity
NPA43_17580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPA43_17580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NPA43_17585	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NPA43_17585	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NPA43_17590	COG0346	lactoylglutathione lyase activity
NPA43_17595	COG0726	polysaccharide deacetylase
NPA43_17600	COG1447	Phosphotransferase system cellobiose-specific component IIA
NPA43_17605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NPA43_17605	COG3711	transcriptional antiterminator
NPA43_17630	COG1757	Na H antiporter
NPA43_17635	COG1027	Aspartate ammonia-lyase
NPA43_17640	COG0252	asparaginase activity
NPA43_17645	COG1396	sequence-specific DNA binding
NPA43_17670	COG4842	Belongs to the WXG100 family
NPA43_17675	COG2195	Cleaves the N-terminal amino acid of tripeptides
NPA43_17685	COG1737	Transcriptional regulator
NPA43_17690	COG2084	Dehydrogenase
NPA43_17700	COG2610	gluconate transmembrane transporter activity
NPA43_17705	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NPA43_17715	COG2723	6-phospho-beta-galactosidase activity
NPA43_17720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_17720	COG2190	(PTS) system
NPA43_17720	COG1263	PTS System
NPA43_17725	COG3711	transcriptional antiterminator
NPA43_17730	COG3878	Protein conserved in bacteria
NPA43_17740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPA43_17745	COG1122	ATPase activity
NPA43_17750	COG4721	ABC-type cobalt transport system, permease component
NPA43_17755	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NPA43_17790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NPA43_17795	COG0778	Nitroreductase
NPA43_17800	COG1846	Transcriptional regulator
NPA43_17805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NPA43_17810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NPA43_17815	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NPA43_17820	COG2390	Transcriptional regulator
NPA43_17830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NPA43_17830	COG2755	lipolytic protein G-D-S-L family
NPA43_17850	COG0561	phosphatase activity
NPA43_17855	COG0789	Transcriptional regulator
NPA43_17860	COG0673	inositol 2-dehydrogenase activity
NPA43_17865	COG0840	transmembrane signaling receptor activity
NPA43_17870	COG1113	amino acid transport
NPA43_17875	COG4335	DNA alkylation repair
NPA43_17885	COG1070	Carbohydrate kinase
NPA43_17890	COG1737	Transcriptional regulator
NPA43_17925	COG0583	DNA-binding transcription factor activity
NPA43_17930	COG1609	Transcriptional regulator
NPA43_17935	COG2182	Extracellular solute-binding protein
NPA43_17940	COG1175	transmembrane transport
NPA43_17945	COG3833	ABC-type maltose transport systems, permease component
NPA43_17955	COG1874	Beta-galactosidase
NPA43_17960	COG2851	Citrate transporter
NPA43_17975	COG1131	(ABC) transporter
NPA43_17980	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NPA43_17985	COG1131	(ABC) transporter
NPA43_18015	COG2824	Alkylphosphonate utilization operon protein PhnA
NPA43_18020	COG1929	Belongs to the glycerate kinase type-1 family
NPA43_18025	COG2610	gluconate transmembrane transporter activity
NPA43_18030	COG3835	regulator
NPA43_18035	COG1309	transcriptional regulator
NPA43_18040	COG2814	Major facilitator Superfamily
NPA43_18050	COG1136	(ABC) transporter
NPA43_18055	COG0457	Tetratricopeptide repeat
NPA43_18060	COG3711	transcriptional antiterminator
NPA43_18065	COG2723	6-phospho-beta-galactosidase activity
NPA43_18070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NPA43_18070	COG1263	PTS System
NPA43_18070	COG2190	(PTS) system
NPA43_18090	COG0494	nUDIX hydrolase
NPA43_18105	COG1113	amino acid transport
NPA43_18110	COG1609	Transcriptional regulator
NPA43_18115	COG2814	Major facilitator Superfamily
NPA43_18125	COG2814	Major facilitator Superfamily
NPA43_18135	COG5444	nuclease activity
NPA43_18150	COG2723	6-phospho-beta-galactosidase activity
NPA43_18160	COG2188	Transcriptional regulator
NPA43_18185	COG1476	TRANSCRIPTIONal
NPA43_18200	COG5002	protein histidine kinase activity
NPA43_18200	COG3850	Histidine kinase
NPA43_18210	COG2409	Drug exporters of the RND superfamily
NPA43_18250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NPA43_18260	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NPA43_18270	COG4720	Psort location CytoplasmicMembrane, score
NPA43_18290	COG0456	acetyltransferase
NPA43_18295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NPA43_18300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NPA43_18305	COG4853	Protein conserved in bacteria
NPA43_18310	COG4863	YycH protein
NPA43_18315	COG5002	protein histidine kinase activity
NPA43_18320	COG0745	RESPONSE REGULATOR receiver
NPA43_18345	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NPA43_18355	COG2311	Membrane
NPA43_18360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NPA43_18365	COG1309	transcriptional regulator
NPA43_18370	COG2124	cytochrome p450
NPA43_18375	COG0346	lactoylglutathione lyase activity
NPA43_18380	COG0305	Participates in initiation and elongation during chromosome replication
NPA43_18400	COG2819	hydrolase of the alpha beta superfamily
NPA43_18405	COG1028	Short-chain dehydrogenase reductase Sdr
NPA43_18410	COG1169	isochorismate synthase
NPA43_18415	COG1021	2,3-dihydroxybenzoate-AMP ligase
NPA43_18420	COG1535	isochorismatase
NPA43_18420	COG3433	isochorismatase activity
NPA43_18425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NPA43_18430	COG3251	PFAM MbtH domain protein
NPA43_18435	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_18435	COG2207	Transcriptional regulator
NPA43_18440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NPA43_18445	COG2819	hydrolase of the alpha beta superfamily
NPA43_18450	COG3093	addiction module antidote protein HigA
NPA43_18455	COG2807	transmembrane transport
NPA43_18460	COG0359	binds to the 23S rRNA
NPA43_18465	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NPA43_18470	COG4241	membrane
NPA43_18475	COG1227	inorganic diphosphatase activity
NPA43_18485	COG1595	DNA-templated transcription, initiation
NPA43_18495	COG0753	catalase activity
NPA43_18500	COG0655	NAD(P)H dehydrogenase (quinone) activity
NPA43_18505	COG0400	carboxylic ester hydrolase activity
NPA43_18510	COG0346	lactoylglutathione lyase activity
NPA43_18525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NPA43_18530	COG0629	single-stranded DNA binding
NPA43_18535	COG0360	Binds together with S18 to 16S ribosomal RNA
NPA43_18540	COG0012	GTP binding
NPA43_18545	COG4481	Protein conserved in bacteria
NPA43_18560	COG3949	Membrane
NPA43_18570	COG1475	DNA binding
NPA43_18575	COG1192	Involved in chromosome partitioning
NPA43_18590	COG1475	DNA binding
NPA43_18595	COG0357	Ribosomal RNA small subunit methyltransferase G
NPA43_18600	COG0445	tRNA wobble uridine modification
NPA43_18605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NPA43_18610	COG1847	R3H domain protein
NPA43_18615	COG0706	membrane insertase activity
NPA43_18620	COG0594	ribonuclease P activity
NPA43_18625	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NPA43_18675	COG0741	lytic transglycosylase activity
NPA43_18675	COG0791	NLP P60 protein
NPA43_18740	COG0629	single-stranded DNA binding
NPA43_18765	COG1525	nuclease
NPA43_18860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NPA43_19015	COG0457	Tetratricopeptide repeat
NPA43_19020	COG2002	toxin-antitoxin pair type II binding
NPA43_19050	COG2337	Toxic component of a toxin-antitoxin (TA) module
NPA43_19075	COG0457	Tetratricopeptide repeat