locus-tag	class	description
AKO65_00020	COG0735	belongs to the Fur family
AKO65_00025	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO65_00030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO65_00035	COG4129	membrane
AKO65_00050	COG0747	negative chemotaxis
AKO65_00055	COG4608	Belongs to the ABC transporter superfamily
AKO65_00060	COG0444	Belongs to the ABC transporter superfamily
AKO65_00065	COG1132	(ABC) transporter
AKO65_00070	COG3557	Belongs to the UPF0374 family
AKO65_00085	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_00095	COG1194	a g-specific adenine glycosylase
AKO65_00100	COG1988	membrane-bound metal-dependent
AKO65_00110	COG1191	sigma factor activity
AKO65_00115	COG2140	Oxalate decarboxylase
AKO65_00130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKO65_00135	COG4485	Bacterial membrane protein, YfhO
AKO65_00140	COG0463	Glycosyl transferase, family 2
AKO65_00160	COG2137	regulation of response to DNA damage stimulus
AKO65_00165	COG1090	epimerase
AKO65_00175	COG0778	Nitroreductase
AKO65_00195	COG0392	lysyltransferase activity
AKO65_00195	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AKO65_00200	COG1846	Transcriptional regulator
AKO65_00210	COG2318	DinB family
AKO65_00230	COG1595	DNA-templated transcription, initiation
AKO65_00235	COG1742	UPF0060 membrane protein
AKO65_00240	COG1132	(ABC) transporter
AKO65_00245	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO65_00250	COG2169	Transcriptional regulator
AKO65_00255	COG0492	ferredoxin-NADP+ reductase activity
AKO65_00260	COG2755	lipolytic protein G-D-S-L family
AKO65_00265	COG4637	Psort location Cytoplasmic, score
AKO65_00275	COG1309	transcriptional regulator
AKO65_00280	COG2076	Multidrug Resistance protein
AKO65_00285	COG2076	Multidrug Resistance protein
AKO65_00340	COG2814	Major facilitator Superfamily
AKO65_00345	COG0789	Transcriptional regulator
AKO65_00350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO65_00355	COG1942	4-Oxalocrotonate Tautomerase
AKO65_00360	COG0583	DNA-binding transcription factor activity
AKO65_00375	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO65_00380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AKO65_00390	COG0598	Magnesium transport protein CorA
AKO65_00400	COG0726	polysaccharide deacetylase
AKO65_00410	COG0535	radical SAM domain protein
AKO65_00415	COG0668	transmembrane transport
AKO65_00425	COG0217	transcriptional regulatory protein
AKO65_00435	COG0387	Pfam Sodium calcium exchanger
AKO65_00445	COG0477	Major facilitator Superfamily
AKO65_00450	COG1295	ribonuclease BN
AKO65_00455	COG4980	gas vesicle protein
AKO65_00460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO65_00465	COG1115	amino acid carrier protein
AKO65_00470	COG4840	Belongs to the UPF0435 family
AKO65_00475	COG0693	protein deglycase activity
AKO65_00480	COG0737	Belongs to the 5'-nucleotidase family
AKO65_00490	COG2188	Transcriptional regulator
AKO65_00495	COG0366	Alpha amylase catalytic
AKO65_00500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_00500	COG1263	PTS System
AKO65_00515	COG0076	glutamate decarboxylase activity
AKO65_00520	COG1368	sulfuric ester hydrolase activity
AKO65_00535	COG3739	integral membrane protein
AKO65_00540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_00540	COG1263	PTS System
AKO65_00545	COG0024	Methionine aminopeptidase
AKO65_00550	COG2258	MOSC domain
AKO65_00555	COG1254	Belongs to the acylphosphatase family
AKO65_00565	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AKO65_00570	COG1695	Transcriptional regulator
AKO65_00575	COG3479	Phenolic acid decarboxylase
AKO65_00585	COG2851	Citrate transporter
AKO65_00590	COG3181	Tripartite tricarboxylate transporter family receptor
AKO65_00595	COG4565	transcriptional regulatory protein
AKO65_00600	COG3290	protein histidine kinase activity
AKO65_00610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_00610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_00620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKO65_00625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_00625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_00645	COG2130	NADP-dependent
AKO65_00650	COG0513	Belongs to the DEAD box helicase family
AKO65_00655	COG0488	(ABC) transporter
AKO65_00660	COG2814	Major facilitator Superfamily
AKO65_00665	COG0789	Transcriptional regulator
AKO65_00670	COG1469	GTP cyclohydrolase I activity
AKO65_00675	COG0488	(ABC) transporter
AKO65_00680	COG0463	Glycosyl transferase, family 2
AKO65_00680	COG0457	Tetratricopeptide repeat
AKO65_00685	COG0531	amino acid
AKO65_00700	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO65_00715	COG0471	metal ion transport
AKO65_00725	COG2223	nitrite transmembrane transporter activity
AKO65_00730	COG1442	glycosyl transferase family 8
AKO65_00735	COG1216	Glycosyl transferase, family 2
AKO65_00740	COG1442	glycosyl transferase family 8
AKO65_00745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO65_00750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKO65_00775	COG2211	Major facilitator Superfamily
AKO65_00785	COG1486	melibiose metabolic process
AKO65_00800	COG0492	ferredoxin-NADP+ reductase activity
AKO65_00805	COG1959	2 iron, 2 sulfur cluster binding
AKO65_00820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO65_00825	COG5444	nuclease activity
AKO65_00835	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO65_00840	COG1597	lipid kinase activity
AKO65_00845	COG1957	nucleoside hydrolase
AKO65_00850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO65_00855	COG1309	transcriptional regulator
AKO65_00860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO65_00865	COG0154	amidase activity
AKO65_00870	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO65_00875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO65_00880	COG1285	pathogenesis
AKO65_00885	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO65_00890	COG4851	CamS sex pheromone cAM373 precursor
AKO65_00895	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKO65_00900	COG0210	DNA helicase
AKO65_00905	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AKO65_00920	COG0069	glutamate synthase activity
AKO65_00930	COG4496	protein, YerC YecD
AKO65_00935	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO65_00945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO65_00950	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKO65_00955	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKO65_00960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO65_00980	COG0151	Belongs to the GarS family
AKO65_00985	COG0138	bifunctional purine biosynthesis protein purh
AKO65_00990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKO65_00995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKO65_01000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKO65_01005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO65_01010	COG0047	phosphoribosylformylglycinamidine synthase activity
AKO65_01015	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO65_01020	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKO65_01025	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKO65_01030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKO65_01035	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKO65_01045	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AKO65_01050	COG3064	Membrane
AKO65_01055	COG5583	Uncharacterized small protein (DUF2292)
AKO65_01060	COG2252	PERMEase
AKO65_01065	COG0583	DNA-binding transcription factor activity
AKO65_01070	COG2814	Major facilitator Superfamily
AKO65_01080	COG1595	DNA-templated transcription, initiation
AKO65_01100	COG3279	Response regulator of the LytR AlgR family
AKO65_01130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO65_01140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKO65_01150	COG0519	Catalyzes the synthesis of GMP from XMP
AKO65_01150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKO65_01155	COG1305	Transglutaminase-like
AKO65_01160	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AKO65_01165	COG0714	Associated with various cellular activities
AKO65_01170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO65_01175	COG1113	amino acid transport
AKO65_01180	COG2132	Multicopper oxidase
AKO65_01190	COG0823	Involved in the tonB-independent uptake of proteins
AKO65_01195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKO65_01220	COG1876	peptidase activity
AKO65_01225	COG2808	Putative FMN-binding domain
AKO65_01230	COG1846	Transcriptional regulator
AKO65_01255	COG0459	protein refolding
AKO65_01260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKO65_01265	COG1266	CAAX protease self-immunity
AKO65_01280	COG0805	protein transport
AKO65_01285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKO65_01290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AKO65_01295	COG0315	cyclic pyranopterin monophosphate synthase activity
AKO65_01300	COG0488	(ABC) transporter
AKO65_01305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKO65_01310	COG0456	acetyltransferase
AKO65_01315	COG1214	PFAM Peptidase M22, glycoprotease
AKO65_01320	COG0802	atpase or kinase
AKO65_01325	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKO65_01375	COG1301	dicarboxylic acid transport
AKO65_01385	COG0697	spore germination
AKO65_01390	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKO65_01410	COG0456	acetyltransferase
AKO65_01420	COG1396	sequence-specific DNA binding
AKO65_01435	COG0778	Nitroreductase
AKO65_01440	COG1846	Transcriptional regulator
AKO65_01445	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO65_01450	COG1309	transcriptional regulator
AKO65_01495	COG2814	Major facilitator Superfamily
AKO65_01520	COG0252	asparaginase activity
AKO65_01530	COG4221	oxidoreductase activity
AKO65_01545	COG0477	Major facilitator Superfamily
AKO65_01560	COG0789	Transcriptional regulator
AKO65_01565	COG1064	alcohol dehydrogenase
AKO65_01570	COG1329	Transcriptional regulator
AKO65_01575	COG1278	Cold shock
AKO65_01590	COG0433	COG0433 Predicted ATPase
AKO65_01630	COG3091	SprT-like family
AKO65_01635	COG2183	response to ionizing radiation
AKO65_01640	COG2208	phosphoserine phosphatase activity
AKO65_01645	COG1191	sigma factor activity
AKO65_01650	COG2172	sigma factor antagonist activity
AKO65_01655	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_01660	COG2208	phosphoserine phosphatase activity
AKO65_01665	COG2172	sigma factor antagonist activity
AKO65_01670	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_01675	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_01680	COG2337	Toxic component of a toxin-antitoxin (TA) module
AKO65_01685	COG0864	Transcriptional regulator
AKO65_01690	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO65_01695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AKO65_01700	COG0736	holo-[acyl-carrier-protein] synthase activity
AKO65_01705	COG0705	Rhomboid family
AKO65_01710	COG3428	Bacterial PH domain
AKO65_01715	COG3402	PFAM membrane-flanked domain
AKO65_01720	COG0513	Belongs to the DEAD box helicase family
AKO65_01735	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKO65_01740	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO65_01745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_01760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO65_01765	COG1131	(ABC) transporter
AKO65_01770	COG1301	dicarboxylic acid transport
AKO65_01775	COG0628	permease
AKO65_01780	COG1301	dicarboxylic acid transport
AKO65_01785	COG4565	transcriptional regulatory protein
AKO65_01790	COG3290	protein histidine kinase activity
AKO65_01795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKO65_01800	COG2217	Heavy metal translocating P-type atpase
AKO65_01805	COG2261	transglycosylase associated protein
AKO65_01810	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO65_01815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_01835	COG5444	nuclease activity
AKO65_01840	COG0028	Belongs to the TPP enzyme family
AKO65_01845	COG0531	amino acid
AKO65_01855	COG1215	transferase activity, transferring glycosyl groups
AKO65_01860	COG5298	Protein conserved in bacteria
AKO65_01865	COG3706	GGDEF domain
AKO65_01870	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AKO65_01875	COG0551	DNA topoisomerase type I activity
AKO65_01875	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO65_01880	COG2814	Major facilitator Superfamily
AKO65_01900	COG3871	stress protein (general stress protein 26)
AKO65_01905	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_01910	COG2226	methyltransferase
AKO65_01915	COG3711	transcriptional antiterminator
AKO65_01925	COG2755	lipolytic protein G-D-S-L family
AKO65_01930	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO65_01935	COG1414	Transcriptional regulator
AKO65_01940	COG1984	allophanate hydrolase subunit 2
AKO65_01945	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKO65_01950	COG4336	lyase activity
AKO65_01955	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO65_01960	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKO65_01965	COG0457	Tetratricopeptide repeat
AKO65_01980	COG0561	phosphatase activity
AKO65_01990	COG0346	lactoylglutathione lyase activity
AKO65_02025	COG0840	transmembrane signaling receptor activity
AKO65_02030	COG0246	Mannitol dehydrogenase
AKO65_02035	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_02040	COG2213	PTS system mannitol-specific
AKO65_02045	COG2372	response to copper ion
AKO65_02045	COG1276	copper resistance
AKO65_02050	COG4549	nuclear export factor GLE1
AKO65_02055	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO65_02060	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_02065	COG0531	amino acid
AKO65_02070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AKO65_02075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_02080	COG0583	DNA-binding transcription factor activity
AKO65_02090	COG0640	Transcriptional regulator
AKO65_02100	COG1309	transcriptional regulator
AKO65_02105	COG2814	Major facilitator Superfamily
AKO65_02110	COG0527	aspartate kinase activity
AKO65_02115	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_02120	COG5002	protein histidine kinase activity
AKO65_02120	COG3850	Histidine kinase
AKO65_02125	COG0745	RESPONSE REGULATOR receiver
AKO65_02140	COG2079	MmgE PrpD family protein
AKO65_02150	COG1126	abc transporter atp-binding protein
AKO65_02155	COG0765	amino acid transport
AKO65_02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_02175	COG5434	Belongs to the glycosyl hydrolase 28 family
AKO65_02180	COG3104	oligopeptide transport
AKO65_02185	COG0833	amino acid
AKO65_02190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_02195	COG0765	amino acid transport
AKO65_02200	COG1126	abc transporter atp-binding protein
AKO65_02205	COG2364	Membrane
AKO65_02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_02220	COG0697	spore germination
AKO65_02225	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AKO65_02240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_02245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_02250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_02260	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKO65_02265	COG3842	ATPase activity
AKO65_02290	COG3209	COG3209 Rhs family protein
AKO65_02295	COG0840	transmembrane signaling receptor activity
AKO65_02295	COG3290	protein histidine kinase activity
AKO65_02305	COG2746	aminoglycoside 3-N-acetyltransferase activity
AKO65_02310	COG1522	sequence-specific DNA binding
AKO65_02315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO65_02325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_02330	COG0765	amino acid transport
AKO65_02335	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO65_02340	COG2508	Transcriptional regulator
AKO65_02345	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_02350	COG0506	proline dehydrogenase activity
AKO65_02355	COG3541	Predicted nucleotidyltransferase
AKO65_02365	COG3458	cephalosporin-C deacetylase activity
AKO65_02370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO65_02375	COG0583	DNA-binding transcription factor activity
AKO65_02380	COG2226	methyltransferase
AKO65_02385	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKO65_02390	COG1414	Transcriptional regulator
AKO65_02400	COG2271	Major facilitator Superfamily
AKO65_02405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKO65_02415	COG0028	Belongs to the TPP enzyme family
AKO65_02420	COG0710	3-dehydroquinate dehydratase activity
AKO65_02425	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_02435	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKO65_02440	COG3665	Urea carboxylase-associated protein
AKO65_02445	COG1113	amino acid transport
AKO65_02450	COG3403	YqcI/YcgG family
AKO65_02465	COG1280	lysine exporter protein (LysE YggA)
AKO65_02470	COG0738	Major facilitator superfamily
AKO65_02475	COG0673	inositol 2-dehydrogenase activity
AKO65_02480	COG0561	phosphatase activity
AKO65_02485	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO65_02490	COG1609	Transcriptional regulator
AKO65_02495	COG1620	l-lactate permease
AKO65_02500	COG0039	L-malate dehydrogenase activity
AKO65_02505	COG1288	antiporter activity
AKO65_02510	COG1473	amidohydrolase
AKO65_02525	COG2113	Glycine betaine
AKO65_02530	COG4176	ABC-type proline glycine betaine transport system permease component
AKO65_02535	COG4175	Glycine betaine
AKO65_02535	COG0517	IMP dehydrogenase activity
AKO65_02540	COG3853	Toxic anion resistance protein (TelA)
AKO65_02570	COG0861	Integral membrane protein TerC family
AKO65_02575	COG2310	stress, protein
AKO65_02580	COG2310	stress, protein
AKO65_02585	COG2310	stress, protein
AKO65_02590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_02600	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_02605	COG3773	Cell wall hydrolase
AKO65_02620	COG1668	transmembrane transport
AKO65_02625	COG4555	ABC transporter
AKO65_02630	COG3279	Response regulator of the LytR AlgR family
AKO65_02635	COG3290	protein histidine kinase activity
AKO65_02640	COG0667	Aldo Keto reductase
AKO65_02650	COG4585	Histidine kinase
AKO65_02655	COG2197	response regulator
AKO65_02665	COG1405	negative regulation of cell septum assembly
AKO65_02665	COG3012	SEC-C Motif Domain Protein
AKO65_02670	COG0784	Response regulator, receiver
AKO65_02675	COG4191	Histidine kinase
AKO65_02680	COG2066	Belongs to the glutaminase family
AKO65_02685	COG1115	amino acid carrier protein
AKO65_02690	COG0596	Alpha beta hydrolase
AKO65_02700	COG0531	amino acid
AKO65_02705	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_02710	COG1846	Transcriptional regulator
AKO65_02715	COG1063	alcohol dehydrogenase
AKO65_02720	COG1917	Cupin 2, conserved barrel domain protein
AKO65_02725	COG1309	transcriptional regulator
AKO65_02735	COG1404	Belongs to the peptidase S8 family
AKO65_02755	COG2814	Major facilitator Superfamily
AKO65_02765	COG1695	Transcriptional regulator
AKO65_02770	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_02775	COG2040	homocysteine
AKO65_02780	COG0833	amino acid
AKO65_02790	COG1404	Belongs to the peptidase S8 family
AKO65_02800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_02805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_02810	COG0383	alpha-mannosidase activity
AKO65_02815	COG1940	carbohydrate kinase activity
AKO65_02820	COG3711	transcriptional antiterminator
AKO65_02820	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_02835	COG2723	6-phospho-beta-galactosidase activity
AKO65_02840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_02840	COG1263	PTS System
AKO65_02840	COG2190	(PTS) system
AKO65_02845	COG3711	transcriptional antiterminator
AKO65_02855	COG0531	amino acid
AKO65_02865	COG0371	Dehydrogenase
AKO65_02870	COG0656	L-ascorbic acid biosynthetic process
AKO65_02880	COG1683	Conserved Protein
AKO65_02890	COG1846	Transcriptional regulator
AKO65_02905	COG2814	Major facilitator Superfamily
AKO65_02910	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO65_02915	COG0730	response to heat
AKO65_02920	COG0425	Belongs to the sulfur carrier protein TusA family
AKO65_02925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_02925	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_02930	COG0425	Belongs to the sulfur carrier protein TusA family
AKO65_02930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_02940	COG2210	Belongs to the sulfur carrier protein TusA family
AKO65_02945	COG1937	Protein conserved in bacteria
AKO65_02960	COG0640	Transcriptional regulator
AKO65_02970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO65_02975	COG1331	Highly conserved protein containing a thioredoxin domain
AKO65_02985	COG2271	Major facilitator Superfamily
AKO65_02990	COG0584	glycerophosphoryl diester phosphodiesterase
AKO65_02995	COG1113	amino acid transport
AKO65_03010	COG1309	transcriptional regulator
AKO65_03015	COG2207	Transcriptional regulator
AKO65_03020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKO65_03030	COG1476	TRANSCRIPTIONal
AKO65_03050	COG2311	Membrane
AKO65_03060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_03065	COG1413	lyase activity
AKO65_03075	COG1131	(ABC) transporter
AKO65_03080	COG1266	CAAX protease self-immunity
AKO65_03085	COG0535	radical SAM domain protein
AKO65_03100	COG1695	Transcriptional regulator
AKO65_03110	COG1136	(ABC) transporter
AKO65_03120	COG1131	(ABC) transporter
AKO65_03140	COG3852	Histidine kinase
AKO65_03145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKO65_03150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO65_03155	COG4856	YbbR-like protein
AKO65_03160	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO65_03165	COG5662	AntiSigma factor
AKO65_03170	COG1595	DNA-templated transcription, initiation
AKO65_03205	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AKO65_03210	COG1737	Transcriptional regulator
AKO65_03215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_03215	COG1263	PTS System
AKO65_03220	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AKO65_03225	COG1472	Belongs to the glycosyl hydrolase 3 family
AKO65_03230	COG3876	Protein conserved in bacteria
AKO65_03235	COG0385	Bile acid
AKO65_03240	COG0659	secondary active sulfate transmembrane transporter activity
AKO65_03245	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_03285	COG0726	polysaccharide deacetylase
AKO65_03290	COG2194	sulfuric ester hydrolase activity
AKO65_03300	COG0489	protein tyrosine kinase activity
AKO65_03305	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_03330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_03335	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKO65_03340	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKO65_03345	COG0101	tRNA pseudouridine synthase activity
AKO65_03350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO65_03355	COG1122	ATPase activity
AKO65_03360	COG1122	ATPase activity
AKO65_03365	COG0203	ribosomal protein L17
AKO65_03370	COG0202	RNA polymerase activity
AKO65_03375	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKO65_03380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKO65_03385	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKO65_03390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKO65_03395	COG0024	Methionine aminopeptidase
AKO65_03400	COG0563	adenylate kinase activity
AKO65_03405	COG0201	protein transport
AKO65_03410	COG0200	Binds to the 23S rRNA
AKO65_03415	COG1841	ribosomal large subunit assembly
AKO65_03420	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKO65_03425	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKO65_03430	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKO65_03435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKO65_03440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO65_03445	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKO65_03450	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKO65_03455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKO65_03460	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKO65_03465	COG0255	Belongs to the universal ribosomal protein uL29 family
AKO65_03470	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKO65_03475	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKO65_03480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKO65_03485	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKO65_03490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKO65_03495	COG0089	rRNA binding
AKO65_03500	COG0088	Forms part of the polypeptide exit tunnel
AKO65_03505	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKO65_03510	COG0051	transcription antitermination factor activity, RNA binding
AKO65_03515	COG0596	Alpha beta hydrolase
AKO65_03520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKO65_03525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKO65_03530	COG0049	tRNA binding
AKO65_03535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKO65_03540	COG1358	cellular component organization or biogenesis
AKO65_03545	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKO65_03550	COG0085	RNA polymerase activity
AKO65_03555	COG2813	Specifically methylates the guanine in position
AKO65_03560	COG0222	ribosome binding
AKO65_03565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKO65_03570	COG0081	regulation of translation
AKO65_03575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKO65_03580	COG0250	Participates in transcription elongation, termination and antitermination
AKO65_03585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO65_03590	COG1595	DNA-templated transcription, initiation
AKO65_03595	COG3688	RNA-binding protein containing a PIN domain
AKO65_03600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO65_03605	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AKO65_03610	COG0215	cysteine-tRNA ligase activity
AKO65_03615	COG1045	serine acetyltransferase
AKO65_03620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKO65_03625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKO65_03630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKO65_03635	COG4956	integral membrane protein (PIN domain superfamily)
AKO65_03640	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AKO65_03645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKO65_03650	COG0542	response to heat
AKO65_03655	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AKO65_03660	COG3880	PFAM UvrB UvrC protein
AKO65_03665	COG4463	regulation of RNA biosynthetic process
AKO65_03695	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKO65_03700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO65_03705	COG1396	sequence-specific DNA binding
AKO65_03710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKO65_03715	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKO65_03720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKO65_03725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_03730	COG0512	Glutamine amidotransferase of anthranilate synthase
AKO65_03735	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKO65_03740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_03745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO65_03750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKO65_03755	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKO65_03760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKO65_03770	COG0037	tRNA processing
AKO65_03775	COG0515	serine threonine protein kinase
AKO65_03780	COG2304	oxidoreductase activity
AKO65_03785	COG2208	phosphoserine phosphatase activity
AKO65_03800	COG1098	S1 RNA binding domain
AKO65_03805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKO65_03820	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKO65_03825	COG3956	TIGRFAM MazG family protein
AKO65_03830	COG2244	polysaccharide biosynthetic process
AKO65_03835	COG2002	toxin-antitoxin pair type II binding
AKO65_03840	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKO65_03850	COG0193	aminoacyl-tRNA hydrolase activity
AKO65_03855	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKO65_03860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKO65_03870	COG2088	sporulation resulting in formation of a cellular spore
AKO65_03875	COG0251	oxidation-reduction process
AKO65_03880	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO65_03885	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKO65_03895	COG4466	Protein conserved in bacteria
AKO65_03905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKO65_03910	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO65_03915	COG3583	domain protein
AKO65_03915	COG3584	3D domain protein
AKO65_03920	COG0084	hydrolase, TatD family'
AKO65_03925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_03925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_03930	COG2002	toxin-antitoxin pair type II binding
AKO65_03935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKO65_03940	COG2827	Endonuclease containing a URI domain
AKO65_03945	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKO65_03950	COG4467	Involved in initiation control of chromosome replication
AKO65_03955	COG1774	PSP1 C-terminal conserved region
AKO65_03960	COG0470	DNA polymerase III
AKO65_03965	COG1728	Protein conserved in bacteria
AKO65_03970	COG3870	Protein conserved in bacteria
AKO65_03975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKO65_03980	COG1982	Orn Lys Arg decarboxylase major
AKO65_03985	COG3853	Toxic anion resistance protein (TelA)
AKO65_03990	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
AKO65_04035	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKO65_04040	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKO65_04045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKO65_04050	COG0590	tRNA wobble adenosine to inosine editing
AKO65_04055	COG1335	isochorismatase
AKO65_04060	COG3858	chitin binding
AKO65_04060	COG1388	LysM domain
AKO65_04065	COG1428	Deoxynucleoside kinase
AKO65_04070	COG1428	Deoxynucleoside kinase
AKO65_04080	COG0840	transmembrane signaling receptor activity
AKO65_04085	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKO65_04090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AKO65_04095	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AKO65_04100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_04105	COG1686	Belongs to the peptidase S11 family
AKO65_04110	COG0517	IMP dehydrogenase activity
AKO65_04110	COG0516	GMP reductase activity
AKO65_04145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO65_04150	COG0187	DNA topoisomerase II activity
AKO65_04160	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKO65_04165	COG2501	S4 domain
AKO65_04170	COG0592	DNA-directed DNA polymerase activity
AKO65_04175	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKO65_04180	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKO65_04185	COG0594	ribonuclease P activity
AKO65_04190	COG0706	membrane insertase activity
AKO65_04195	COG1847	R3H domain protein
AKO65_04200	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKO65_04205	COG0445	tRNA wobble uridine modification
AKO65_04210	COG0357	Ribosomal RNA small subunit methyltransferase G
AKO65_04215	COG1475	DNA binding
AKO65_04225	COG1192	Involved in chromosome partitioning
AKO65_04230	COG1475	DNA binding
AKO65_04240	COG3949	Membrane
AKO65_04255	COG4481	Protein conserved in bacteria
AKO65_04260	COG0012	GTP binding
AKO65_04265	COG0360	Binds together with S18 to 16S ribosomal RNA
AKO65_04270	COG0629	single-stranded DNA binding
AKO65_04275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKO65_04280	COG1125	glycine betaine transport
AKO65_04280	COG0517	IMP dehydrogenase activity
AKO65_04285	COG1174	glycine betaine transport
AKO65_04290	COG0346	lactoylglutathione lyase activity
AKO65_04295	COG0400	carboxylic ester hydrolase activity
AKO65_04300	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO65_04305	COG0753	catalase activity
AKO65_04315	COG1595	DNA-templated transcription, initiation
AKO65_04325	COG1227	inorganic diphosphatase activity
AKO65_04330	COG4241	membrane
AKO65_04335	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AKO65_04340	COG0359	binds to the 23S rRNA
AKO65_04345	COG2807	transmembrane transport
AKO65_04350	COG2819	hydrolase of the alpha beta superfamily
AKO65_04355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_04360	COG2207	Transcriptional regulator
AKO65_04360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_04365	COG2819	hydrolase of the alpha beta superfamily
AKO65_04385	COG0305	Participates in initiation and elongation during chromosome replication
AKO65_04390	COG0346	lactoylglutathione lyase activity
AKO65_04395	COG2124	cytochrome p450
AKO65_04400	COG1309	transcriptional regulator
AKO65_04405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKO65_04410	COG2311	Membrane
AKO65_04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO65_04445	COG0745	RESPONSE REGULATOR receiver
AKO65_04450	COG5002	protein histidine kinase activity
AKO65_04455	COG4863	YycH protein
AKO65_04460	COG4853	Protein conserved in bacteria
AKO65_04465	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AKO65_04470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_04475	COG0456	acetyltransferase
AKO65_04495	COG4720	Psort location CytoplasmicMembrane, score
AKO65_04505	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO65_04510	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKO65_04540	COG2409	Drug exporters of the RND superfamily
AKO65_04550	COG3850	Histidine kinase
AKO65_04550	COG5002	protein histidine kinase activity
AKO65_04565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKO65_04585	COG0583	DNA-binding transcription factor activity
AKO65_04590	COG0384	phenazine biosynthesis protein PhzF
AKO65_04605	COG2188	Transcriptional regulator
AKO65_04610	COG1263	PTS System
AKO65_04610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_04610	COG2190	(PTS) system
AKO65_04615	COG2723	6-phospho-beta-galactosidase activity
AKO65_04645	COG2814	Major facilitator Superfamily
AKO65_04650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO65_04655	COG2814	Major facilitator Superfamily
AKO65_04665	COG1113	amino acid transport
AKO65_04680	COG0494	nUDIX hydrolase
AKO65_04705	COG1263	PTS System
AKO65_04705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_04705	COG2190	(PTS) system
AKO65_04710	COG2723	6-phospho-beta-galactosidase activity
AKO65_04715	COG3711	transcriptional antiterminator
AKO65_04720	COG0457	Tetratricopeptide repeat
AKO65_04730	COG1136	(ABC) transporter
AKO65_04740	COG2814	Major facilitator Superfamily
AKO65_04745	COG1309	transcriptional regulator
AKO65_04750	COG3835	regulator
AKO65_04755	COG2610	gluconate transmembrane transporter activity
AKO65_04760	COG1929	Belongs to the glycerate kinase type-1 family
AKO65_04765	COG2824	Alkylphosphonate utilization operon protein PhnA
AKO65_04770	COG1131	(ABC) transporter
AKO65_04775	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO65_04785	COG2851	Citrate transporter
AKO65_04790	COG1874	Beta-galactosidase
AKO65_04800	COG3833	ABC-type maltose transport systems, permease component
AKO65_04805	COG1175	transmembrane transport
AKO65_04810	COG2182	Extracellular solute-binding protein
AKO65_04815	COG1609	Transcriptional regulator
AKO65_04820	COG0583	DNA-binding transcription factor activity
AKO65_04860	COG1737	Transcriptional regulator
AKO65_04865	COG1070	Carbohydrate kinase
AKO65_04875	COG4335	DNA alkylation repair
AKO65_04880	COG1113	amino acid transport
AKO65_04885	COG0840	transmembrane signaling receptor activity
AKO65_04890	COG0673	inositol 2-dehydrogenase activity
AKO65_04895	COG0789	Transcriptional regulator
AKO65_04900	COG0561	phosphatase activity
AKO65_04910	COG2226	methyltransferase
AKO65_04915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO65_04920	COG0477	Major facilitator Superfamily
AKO65_04925	COG2755	lipolytic protein G-D-S-L family
AKO65_04925	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKO65_04935	COG2390	Transcriptional regulator
AKO65_04940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKO65_04945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AKO65_04950	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AKO65_04955	COG1846	Transcriptional regulator
AKO65_04960	COG0778	Nitroreductase
AKO65_04965	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AKO65_04970	COG3291	Pkd domain containing protein
AKO65_04970	COG4412	M6 family metalloprotease domain protein
AKO65_04995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO65_05000	COG4721	ABC-type cobalt transport system, permease component
AKO65_05005	COG1122	ATPase activity
AKO65_05010	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO65_05020	COG3878	Protein conserved in bacteria
AKO65_05025	COG3711	transcriptional antiterminator
AKO65_05030	COG1263	PTS System
AKO65_05030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_05030	COG2190	(PTS) system
AKO65_05035	COG2723	6-phospho-beta-galactosidase activity
AKO65_05060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO65_05065	COG2610	gluconate transmembrane transporter activity
AKO65_05075	COG2084	Dehydrogenase
AKO65_05080	COG1737	Transcriptional regulator
AKO65_05095	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO65_05100	COG4842	Belongs to the WXG100 family
AKO65_05125	COG1396	sequence-specific DNA binding
AKO65_05130	COG0252	asparaginase activity
AKO65_05135	COG1027	Aspartate ammonia-lyase
AKO65_05140	COG1757	Na H antiporter
AKO65_05165	COG3711	transcriptional antiterminator
AKO65_05165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_05170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_05175	COG1312	Catalyzes the dehydration of D-mannonate
AKO65_05180	COG2723	6-phospho-beta-galactosidase activity
AKO65_05185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_05190	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO65_05195	COG0726	polysaccharide deacetylase
AKO65_05205	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_05205	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO65_05210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_05210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO65_05215	COG2514	catechol 2,3-dioxygenase activity
AKO65_05220	COG1733	regulation of RNA biosynthetic process
AKO65_05225	COG5386	Cell surface protein
AKO65_05230	COG5386	Cell surface protein
AKO65_05255	COG4509	Sortase family
AKO65_05260	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO65_05265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_05270	COG1120	ATPase activity
AKO65_05275	COG1271	oxidase subunit
AKO65_05280	COG1294	oxidase, subunit
AKO65_05285	COG4988	ABC transporter
AKO65_05290	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKO65_05295	COG3866	Pectate lyase
AKO65_05300	COG1595	DNA-templated transcription, initiation
AKO65_05315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO65_05330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_05330	COG3711	transcriptional antiterminator
AKO65_05335	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_05340	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_05345	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO65_05350	COG1486	melibiose metabolic process
AKO65_05365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_05370	COG3420	alginic acid biosynthetic process
AKO65_05380	COG1129	ABC transporter
AKO65_05385	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO65_05390	COG2357	RelA SpoT domain protein
AKO65_05395	COG0457	Tetratricopeptide repeat
AKO65_05400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_05405	COG0765	amino acid transport
AKO65_05420	COG0346	lactoylglutathione lyase activity
AKO65_05425	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKO65_05430	COG1346	cytolysis
AKO65_05435	COG1380	Effector of murein hydrolase LrgA
AKO65_05440	COG0583	DNA-binding transcription factor activity
AKO65_05445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKO65_05450	COG0352	thiamine-phosphate diphosphorylase activity
AKO65_05465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO65_05470	COG3162	membrane
AKO65_05480	COG4106	trans-aconitate 2-methyltransferase activity
AKO65_05490	COG2246	polysaccharide biosynthetic process
AKO65_05505	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AKO65_05510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKO65_05515	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AKO65_05525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO65_05530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO65_05535	COG1845	cytochrome c oxidase, subunit III
AKO65_05540	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO65_05550	COG0772	Belongs to the SEDS family
AKO65_05555	COG0778	Nitroreductase
AKO65_05560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_05570	COG1404	Belongs to the peptidase S8 family
AKO65_05580	COG3711	transcriptional antiterminator
AKO65_05585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_05585	COG1263	PTS System
AKO65_05590	COG1621	beta-fructofuranosidase activity
AKO65_05605	COG0351	phosphomethylpyrimidine kinase
AKO65_05615	COG1216	Glycosyl transferase, family 2
AKO65_05620	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKO65_05625	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_05635	COG2233	PERMEase
AKO65_05640	COG2363	Small membrane protein
AKO65_05660	COG0463	Glycosyl transferase, family 2
AKO65_05665	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_05670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO65_05675	COG0456	acetyltransferase
AKO65_05680	COG2089	acid synthase
AKO65_05685	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AKO65_05690	COG3980	spore coat polysaccharide biosynthesis protein
AKO65_05695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO65_05700	COG1088	dTDP-glucose 4,6-dehydratase activity
AKO65_05705	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKO65_05710	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AKO65_05715	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_05720	COG0436	Aminotransferase
AKO65_05725	COG0151	Belongs to the GarS family
AKO65_05730	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_05735	COG1917	Cupin 2, conserved barrel domain protein
AKO65_05740	COG0077	Prephenate dehydratase
AKO65_05745	COG2814	Major facilitator Superfamily
AKO65_05750	COG1522	sequence-specific DNA binding
AKO65_05755	COG2814	Major facilitator Superfamily
AKO65_05765	COG0280	phosphate acetyltransferase
AKO65_05775	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKO65_05805	COG5444	nuclease activity
AKO65_05855	COG4844	belongs to the
AKO65_05860	COG1078	dGTPase activity
AKO65_05865	COG3465	dGTPase activity
AKO65_05875	COG1942	4-Oxalocrotonate Tautomerase
AKO65_05880	COG1994	Peptidase M50
AKO65_05890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_05895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKO65_05900	COG0010	Belongs to the arginase family
AKO65_05910	COG4506	Protein conserved in bacteria
AKO65_05915	COG0018	arginyl-trna synthetase
AKO65_05920	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO65_05925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_05930	COG1132	(ABC) transporter
AKO65_05935	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO65_05945	COG4294	response to UV
AKO65_05950	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_05955	COG0247	lactate metabolic process
AKO65_05955	COG2181	nitrate reductase activity
AKO65_05960	COG0183	Belongs to the thiolase family
AKO65_05965	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO65_05970	COG1960	acyl-CoA dehydrogenase activity
AKO65_05975	COG1960	acyl-CoA dehydrogenase activity
AKO65_06000	COG1131	(ABC) transporter
AKO65_06010	COG3343	RNA polymerase activity
AKO65_06015	COG0504	CTP synthase activity
AKO65_06020	COG4821	SIS domain
AKO65_06025	COG2204	response regulator
AKO65_06030	COG0191	fructose-bisphosphate aldolase activity
AKO65_06035	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKO65_06040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO65_06045	COG1494	fructose-1,6-bisphosphatase
AKO65_06050	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKO65_06055	COG0254	rRNA binding
AKO65_06060	COG1435	thymidine kinase activity
AKO65_06065	COG0281	malic enzyme
AKO65_06070	COG0679	Auxin Efflux Carrier
AKO65_06075	COG0789	Transcriptional regulator
AKO65_06080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKO65_06085	COG2890	protein-(glutamine-N5) methyltransferase activity
AKO65_06100	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AKO65_06105	COG0009	L-threonylcarbamoyladenylate synthase
AKO65_06110	COG1971	Probably functions as a manganese efflux pump
AKO65_06115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO65_06120	COG0698	ribose 5-phosphate isomerase
AKO65_06125	COG4475	Protein of unknown function (DUF436)
AKO65_06130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKO65_06135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKO65_06145	COG0356	it plays a direct role in the translocation of protons across the membrane
AKO65_06150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO65_06155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKO65_06160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO65_06165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKO65_06170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKO65_06175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKO65_06180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKO65_06190	COG4836	Membrane
AKO65_06200	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO65_06205	COG2385	sporulation resulting in formation of a cellular spore
AKO65_06210	COG2304	oxidoreductase activity
AKO65_06215	COG2304	oxidoreductase activity
AKO65_06230	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKO65_06235	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AKO65_06240	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO65_06245	COG0523	cobalamin synthesis protein
AKO65_06250	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO65_06260	COG1247	-acetyltransferase
AKO65_06265	COG0739	heme binding
AKO65_06270	COG0347	Belongs to the P(II) protein family
AKO65_06275	COG0004	ammonium transporteR
AKO65_06280	COG1126	abc transporter atp-binding protein
AKO65_06285	COG0765	amino acid transport
AKO65_06290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_06295	COG0477	Major facilitator Superfamily
AKO65_06300	COG0671	phosphoesterase, PA-phosphatase related
AKO65_06305	COG2814	Major facilitator Superfamily
AKO65_06310	COG1846	Transcriptional regulator
AKO65_06315	COG1609	Transcriptional regulator
AKO65_06320	COG1077	Cell shape determining protein MreB Mrl
AKO65_06325	COG4786	Flagellar basal body rod
AKO65_06330	COG4786	Flagellar basal body rod
AKO65_06335	COG0457	Tetratricopeptide repeat
AKO65_06340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKO65_06345	COG1970	mechanosensitive ion channel activity
AKO65_06360	COG0561	phosphatase activity
AKO65_06365	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_06365	COG2202	Pas domain
AKO65_06370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO65_06375	COG4715	Zinc finger, swim domain protein
AKO65_06380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO65_06385	COG2059	Chromate
AKO65_06390	COG2059	Chromate
AKO65_06395	COG1522	sequence-specific DNA binding
AKO65_06400	COG3527	Alpha-acetolactate decarboxylase
AKO65_06405	COG0028	Belongs to the TPP enzyme family
AKO65_06410	COG0583	DNA-binding transcription factor activity
AKO65_06415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKO65_06420	COG1879	ABC-type sugar transport system periplasmic component
AKO65_06425	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO65_06430	COG1129	ABC transporter
AKO65_06435	COG1869	D-ribose catabolic process
AKO65_06440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO65_06445	COG1609	Transcriptional regulator
AKO65_06460	COG0697	spore germination
AKO65_06465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO65_06475	COG2843	Capsule synthesis protein
AKO65_06480	COG0791	NLP P60 protein
AKO65_06485	COG0561	phosphatase activity
AKO65_06490	COG1316	TRANSCRIPTIONal
AKO65_06495	COG2814	Major facilitator Superfamily
AKO65_06510	COG0814	amino acid
AKO65_06515	COG0697	spore germination
AKO65_06520	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_06525	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AKO65_06530	COG1609	Transcriptional regulator
AKO65_06535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO65_06540	COG0800	Aldolase
AKO65_06545	COG0454	-acetyltransferase
AKO65_06555	COG2972	Histidine kinase
AKO65_06560	COG2197	response regulator
AKO65_06565	COG1653	transport
AKO65_06570	COG1175	transmembrane transport
AKO65_06580	COG1482	cell wall glycoprotein biosynthetic process
AKO65_06585	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_06590	COG4193	domain, Protein
AKO65_06595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_06600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKO65_06605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKO65_06615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_06620	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO65_06630	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO65_06635	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO65_06645	COG1216	Glycosyl transferase, family 2
AKO65_06650	COG1682	transport, permease protein
AKO65_06655	COG1134	teichoic acid transport
AKO65_06660	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO65_06665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKO65_06670	COG1316	TRANSCRIPTIONal
AKO65_06680	COG2247	cell wall binding repeat
AKO65_06680	COG2385	sporulation resulting in formation of a cellular spore
AKO65_06685	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_06685	COG2247	cell wall binding repeat
AKO65_06690	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_06690	COG2247	cell wall binding repeat
AKO65_06705	COG2244	polysaccharide biosynthetic process
AKO65_06710	COG0297	glycogen (starch) synthase activity
AKO65_06710	COG0438	transferase activity, transferring glycosyl groups
AKO65_06715	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO65_06720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO65_06725	COG3307	-O-antigen
AKO65_06730	COG3206	protein involved in exopolysaccharide biosynthesis
AKO65_06735	COG1215	transferase activity, transferring glycosyl groups
AKO65_06740	COG0438	transferase activity, transferring glycosyl groups
AKO65_06745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO65_06750	COG1316	TRANSCRIPTIONal
AKO65_06755	COG1739	Uncharacterized protein family UPF0029
AKO65_06760	COG4585	Histidine kinase
AKO65_06765	COG2197	response regulator
AKO65_06770	COG1307	EDD domain protein, DegV family
AKO65_06775	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AKO65_06785	COG1040	competence protein
AKO65_06800	COG3418	PFAM FlgN family protein
AKO65_06805	COG4786	Flagellar basal body rod
AKO65_06805	COG1256	bacterial-type flagellum assembly
AKO65_06810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_06820	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AKO65_06825	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKO65_06830	COG1334	flagellar protein FlaG
AKO65_06835	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKO65_06840	COG1516	flagellar protein fliS
AKO65_06855	COG0840	transmembrane signaling receptor activity
AKO65_06860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKO65_06865	COG0653	protein targeting
AKO65_06870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKO65_06885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_06890	COG2010	Cytochrome c
AKO65_06895	COG2884	Cell division ATP-binding protein ftsE
AKO65_06900	COG2177	Part of the ABC transporter FtsEX involved in
AKO65_06905	COG3883	PFAM NLP P60 protein
AKO65_06905	COG0791	NLP P60 protein
AKO65_06910	COG0730	response to heat
AKO65_06915	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_06915	COG0793	Belongs to the peptidase S41A family
AKO65_06925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_06930	COG1733	regulation of RNA biosynthetic process
AKO65_06935	COG0778	Nitroreductase
AKO65_06940	COG1113	amino acid transport
AKO65_06945	COG0463	Glycosyl transferase, family 2
AKO65_06950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO65_06955	COG5002	protein histidine kinase activity
AKO65_06960	COG0745	RESPONSE REGULATOR receiver
AKO65_06970	COG2814	Major facilitator Superfamily
AKO65_06975	COG1309	transcriptional regulator
AKO65_06980	COG0574	Belongs to the PEP-utilizing enzyme family
AKO65_06980	COG3848	Pyruvate phosphate dikinase
AKO65_06985	COG4897	Protein conserved in bacteria
AKO65_07000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKO65_07015	COG3595	metallopeptidase activity
AKO65_07020	COG1983	PspC domain protein
AKO65_07025	COG1950	PFAM Membrane protein of
AKO65_07030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKO65_07040	COG0363	glucosamine-6-phosphate deaminase activity
AKO65_07045	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKO65_07050	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKO65_07055	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKO65_07060	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AKO65_07065	COG0546	phosphoglycolate phosphatase activity
AKO65_07070	COG0110	maltose O-acetyltransferase activity
AKO65_07075	COG1959	2 iron, 2 sulfur cluster binding
AKO65_07080	COG2910	NAD(P)H-binding
AKO65_07090	COG4990	cell redox homeostasis
AKO65_07095	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKO65_07100	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKO65_07105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKO65_07110	COG0131	Imidazoleglycerol-phosphate dehydratase
AKO65_07115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKO65_07120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKO65_07125	COG0107	imidazoleglycerol-phosphate synthase activity
AKO65_07130	COG0140	phosphoribosyl-ATP diphosphatase activity
AKO65_07130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKO65_07135	COG0457	Tetratricopeptide repeat
AKO65_07140	COG3883	PFAM NLP P60 protein
AKO65_07140	COG0791	NLP P60 protein
AKO65_07145	COG0492	ferredoxin-NADP+ reductase activity
AKO65_07150	COG1051	belongs to the nudix hydrolase family
AKO65_07155	COG1660	Displays ATPase and GTPase activities
AKO65_07160	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKO65_07165	COG1481	regulation of sporulation
AKO65_07170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_07175	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AKO65_07185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO65_07190	COG0288	reversible hydration of carbon dioxide
AKO65_07195	COG0659	secondary active sulfate transmembrane transporter activity
AKO65_07200	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO65_07205	COG1611	Belongs to the LOG family
AKO65_07210	COG0740	serine-type endopeptidase activity
AKO65_07300	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKO65_07305	COG0582	viral genome integration into host DNA
AKO65_07405	COG3953	SLT domain
AKO65_07405	COG5412	phage tail tape measure protein
AKO65_07415	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO65_07415	COG1388	LysM domain
AKO65_07440	COG4824	toxin secretion phage lysis holin
AKO65_07445	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_07470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_07475	COG1819	glycosyl
AKO65_07480	COG0747	negative chemotaxis
AKO65_07485	COG0601	transmembrane transport
AKO65_07500	COG1124	(ABC) transporter
AKO65_07510	COG0726	polysaccharide deacetylase
AKO65_07515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_07520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_07525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_07535	COG1396	sequence-specific DNA binding
AKO65_07540	COG3944	biosynthesis protein
AKO65_07545	COG0489	protein tyrosine kinase activity
AKO65_07550	COG1086	Polysaccharide biosynthesis protein
AKO65_07555	COG0438	transferase activity, transferring glycosyl groups
AKO65_07560	COG1215	transferase activity, transferring glycosyl groups
AKO65_07565	COG0438	transferase activity, transferring glycosyl groups
AKO65_07575	COG1216	Glycosyl transferase, family 2
AKO65_07580	COG5039	Polysaccharide pyruvyl transferase
AKO65_07585	COG2244	polysaccharide biosynthetic process
AKO65_07590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKO65_07595	COG0110	maltose O-acetyltransferase activity
AKO65_07600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO65_07605	COG0747	negative chemotaxis
AKO65_07610	COG0601	transmembrane transport
AKO65_07615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_07620	COG0444	Belongs to the ABC transporter superfamily
AKO65_07625	COG4608	Belongs to the ABC transporter superfamily
AKO65_07630	COG0534	Mate efflux family protein
AKO65_07640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKO65_07645	COG2186	Transcriptional regulator
AKO65_07650	COG3829	transcription factor binding
AKO65_07655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO65_07660	COG0833	amino acid
AKO65_07665	COG2390	Transcriptional regulator
AKO65_07670	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO65_07675	COG0126	phosphoglycerate kinase activity
AKO65_07680	COG0149	triose-phosphate isomerase activity
AKO65_07685	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKO65_07690	COG0148	phosphopyruvate hydratase activity
AKO65_07700	COG1131	(ABC) transporter
AKO65_07720	COG0456	acetyltransferase
AKO65_07730	COG2095	MarC family integral membrane protein
AKO65_07735	COG1510	regulation of RNA biosynthetic process
AKO65_07740	COG0517	IMP dehydrogenase activity
AKO65_07740	COG1125	glycine betaine transport
AKO65_07745	COG1174	glycine betaine transport
AKO65_07750	COG1732	Glycine betaine
AKO65_07755	COG1174	glycine betaine transport
AKO65_07760	COG1733	regulation of RNA biosynthetic process
AKO65_07765	COG1396	sequence-specific DNA binding
AKO65_07770	COG1396	sequence-specific DNA binding
AKO65_07775	COG1476	TRANSCRIPTIONal
AKO65_07780	COG2002	toxin-antitoxin pair type II binding
AKO65_07785	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO65_07790	COG1647	Serine aminopeptidase, S33
AKO65_07795	COG0557	exoribonuclease II activity
AKO65_07800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKO65_07820	COG3706	GGDEF domain
AKO65_07820	COG0745	RESPONSE REGULATOR receiver
AKO65_07830	COG1937	Protein conserved in bacteria
AKO65_07835	COG2608	mercury ion transmembrane transporter activity
AKO65_07840	COG2217	Heavy metal translocating P-type atpase
AKO65_07850	COG1027	Aspartate ammonia-lyase
AKO65_07855	COG4191	Histidine kinase
AKO65_07860	COG0784	Response regulator, receiver
AKO65_07865	COG3226	Transcriptional regulator
AKO65_07875	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO65_07880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO65_07885	COG1121	(ABC) transporter
AKO65_07890	COG2217	Heavy metal translocating P-type atpase
AKO65_07895	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKO65_07900	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AKO65_07905	COG2860	membrane
AKO65_07910	COG0025	NhaP-type Na H and K H
AKO65_07915	COG1940	carbohydrate kinase activity
AKO65_07920	COG0656	L-ascorbic acid biosynthetic process
AKO65_07925	COG4149	molybdate abc transporter
AKO65_07930	COG0725	ABC transporter, periplasmic molybdate-binding protein
AKO65_07935	COG1368	sulfuric ester hydrolase activity
AKO65_07940	COG1988	membrane-bound metal-dependent
AKO65_07960	COG0531	amino acid
AKO65_07965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_07970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_07975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_07980	COG1120	ATPase activity
AKO65_07985	COG0745	RESPONSE REGULATOR receiver
AKO65_07990	COG2205	protein histidine kinase activity
AKO65_07995	COG1904	glucuronate isomerase
AKO65_08000	COG1609	Transcriptional regulator
AKO65_08005	COG0246	Mannitol dehydrogenase
AKO65_08010	COG2721	sulfolactate sulfo-lyase activity
AKO65_08020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_08025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_08030	COG1120	ATPase activity
AKO65_08035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKO65_08040	COG1454	alcohol dehydrogenase
AKO65_08055	COG3604	Transcriptional regulator
AKO65_08065	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKO65_08070	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_08075	COG2096	Adenosyltransferase
AKO65_08080	COG4758	membrane
AKO65_08085	COG1842	Phage shock protein A
AKO65_08095	COG4758	membrane
AKO65_08100	COG4585	Histidine kinase
AKO65_08105	COG2197	response regulator
AKO65_08120	COG0814	amino acid
AKO65_08125	COG0697	spore germination
AKO65_08130	COG0114	fumarate hydratase activity
AKO65_08135	COG1309	transcriptional regulator
AKO65_08140	COG2770	Histidine kinase
AKO65_08140	COG2205	protein histidine kinase activity
AKO65_08145	COG0745	RESPONSE REGULATOR receiver
AKO65_08150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_08155	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_08165	COG1120	ATPase activity
AKO65_08175	COG5577	PFAM Coat F domain
AKO65_08185	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO65_08185	COG1024	Enoyl-CoA hydratase
AKO65_08190	COG0183	Belongs to the thiolase family
AKO65_08195	COG1960	acyl-CoA dehydrogenase activity
AKO65_08200	COG1393	Belongs to the ArsC family
AKO65_08205	COG0509	glycine decarboxylation via glycine cleavage system
AKO65_08215	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO65_08220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_08230	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AKO65_08235	COG2011	ABC-type metal ion transport system permease component
AKO65_08240	COG1464	Belongs to the NlpA lipoprotein family
AKO65_08245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO65_08250	COG0396	ATPase activity
AKO65_08255	COG0719	Fe-S assembly protein
AKO65_08260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKO65_08265	COG0822	iron-sulfur transferase activity
AKO65_08270	COG0719	Fe-S assembly protein
AKO65_08295	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO65_08310	COG2311	Membrane
AKO65_08315	COG0745	RESPONSE REGULATOR receiver
AKO65_08320	COG5002	protein histidine kinase activity
AKO65_08320	COG0642	Histidine kinase
AKO65_08345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_08350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_08355	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_08370	COG2356	endonuclease I
AKO65_08375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKO65_08380	COG2814	Major facilitator Superfamily
AKO65_08385	COG2140	Oxalate decarboxylase
AKO65_08390	COG2508	Transcriptional regulator
AKO65_08395	COG1801	Protein of unknown function DUF72
AKO65_08400	COG0737	Belongs to the 5'-nucleotidase family
AKO65_08405	COG3377	Domain of unknown function (DUF1805)
AKO65_08425	COG0739	heme binding
AKO65_08430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKO65_08440	COG4470	Protein conserved in bacteria
AKO65_08445	COG2445	Protein of unknown function DUF86
AKO65_08450	COG0647	UMP catabolic process
AKO65_08455	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO65_08460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO65_08465	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO65_08470	COG0460	homoserine dehydrogenase
AKO65_08475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AKO65_08480	COG0083	homoserine kinase activity
AKO65_08485	COG4946	Tricorn protease homolog
AKO65_08485	COG0823	Involved in the tonB-independent uptake of proteins
AKO65_08485	COG1506	peptidase
AKO65_08490	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKO65_08495	COG4837	Protein of unknown function (DUF1462)
AKO65_08505	COG1252	NADH dehydrogenase
AKO65_08510	COG4844	belongs to the
AKO65_08515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKO65_08520	COG0316	Belongs to the HesB IscA family
AKO65_08535	COG0492	ferredoxin-NADP+ reductase activity
AKO65_08540	COG1252	NADH dehydrogenase
AKO65_08550	COG3584	3D domain protein
AKO65_08555	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AKO65_08560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKO65_08565	COG2056	Na+-H+ antiporter family
AKO65_08570	COG1268	BioY protein
AKO65_08575	COG0686	Belongs to the AlaDH PNT family
AKO65_08580	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO65_08580	COG2508	Transcriptional regulator
AKO65_08585	COG4842	Belongs to the WXG100 family
AKO65_08590	COG5417	Belongs to the EsaB family
AKO65_08595	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO65_08600	COG1674	ftsk spoiiie
AKO65_08600	COG0433	COG0433 Predicted ATPase
AKO65_08605	COG1511	domain protein
AKO65_08615	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_08620	COG1418	mRNA catabolic process
AKO65_08635	COG0628	permease
AKO65_08655	COG5506	Protein of unknown function (DUF1694)
AKO65_08660	COG1335	isochorismatase
AKO65_08665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKO65_08670	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AKO65_08685	COG0142	geranyltranstransferase activity
AKO65_08695	COG4585	Histidine kinase
AKO65_08700	COG2197	response regulator
AKO65_08705	COG2050	protein possibly involved in aromatic compounds catabolism
AKO65_08710	COG1320	monovalent cation:proton antiporter activity
AKO65_08715	COG2212	antiporter activity
AKO65_08720	COG1863	multisubunit Na H antiporter MnhE subunit
AKO65_08725	COG0651	ATP synthesis coupled electron transport
AKO65_08730	COG1006	Multisubunit Na H antiporter MnhC subunit
AKO65_08735	COG2111	Na H antiporter
AKO65_08740	COG2111	Na H antiporter
AKO65_08740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKO65_08750	COG3493	citrate carrier protein
AKO65_08775	COG4565	transcriptional regulatory protein
AKO65_08780	COG3290	protein histidine kinase activity
AKO65_08790	COG3011	Protein conserved in bacteria
AKO65_08795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_08800	COG2814	Major facilitator Superfamily
AKO65_08805	COG5018	Exonuclease
AKO65_08815	COG2205	protein histidine kinase activity
AKO65_08820	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKO65_08830	COG2267	carboxylic ester hydrolase activity
AKO65_08835	COG1522	sequence-specific DNA binding
AKO65_08840	COG0436	Aminotransferase
AKO65_08845	COG1098	S1 RNA binding domain
AKO65_08850	COG2155	Conserved Protein
AKO65_08855	COG1979	alcohol dehydrogenase
AKO65_08860	COG1979	alcohol dehydrogenase
AKO65_08865	COG0166	Belongs to the GPI family
AKO65_08880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKO65_08890	COG2738	Putative neutral zinc metallopeptidase
AKO65_08895	COG1253	flavin adenine dinucleotide binding
AKO65_08900	COG0432	Pfam Uncharacterised protein family UPF0047
AKO65_08905	COG2070	2-Nitropropane dioxygenase
AKO65_08920	COG0840	transmembrane signaling receptor activity
AKO65_08925	COG0840	transmembrane signaling receptor activity
AKO65_08930	COG0840	transmembrane signaling receptor activity
AKO65_08935	COG0840	transmembrane signaling receptor activity
AKO65_08940	COG0693	protein deglycase activity
AKO65_08945	COG0673	inositol 2-dehydrogenase activity
AKO65_08955	COG0628	permease
AKO65_08970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKO65_08980	COG1396	sequence-specific DNA binding
AKO65_08995	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AKO65_09005	COG1595	DNA-templated transcription, initiation
AKO65_09010	COG5484	DNA packaging
AKO65_09015	COG1783	phage Terminase large subunit
AKO65_09020	COG5518	Phage portal protein
AKO65_09025	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKO65_09030	COG4653	Phage capsid family
AKO65_09075	COG3953	SLT domain
AKO65_09075	COG3953	SLT domain
AKO65_09075	COG5280	Phage tail tape measure protein TP901
AKO65_09075	COG5280	Phage tail tape measure protein TP901
AKO65_09080	COG1652	LysM domain
AKO65_09085	COG4193	domain, Protein
AKO65_09095	COG3628	GPW Gp25 family protein
AKO65_09100	COG3299	homolog of phage Mu protein gp47
AKO65_09105	COG3778	Protein conserved in bacteria
AKO65_09160	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO65_09160	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_09175	COG1510	regulation of RNA biosynthetic process
AKO65_09185	COG1454	alcohol dehydrogenase
AKO65_09190	COG2318	DinB family
AKO65_09195	COG1585	Membrane protein implicated in regulation of membrane protease activity
AKO65_09200	COG2268	Band 7 protein
AKO65_09205	COG0772	Belongs to the SEDS family
AKO65_09210	COG0772	Belongs to the SEDS family
AKO65_09215	COG3339	Conserved Protein
AKO65_09220	COG1247	-acetyltransferase
AKO65_09225	COG3859	Proton-coupled thiamine transporter YuaJ
AKO65_09365	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO65_09370	COG1575	Belongs to the MenA family. Type 1 subfamily
AKO65_09375	COG1169	isochorismate synthase
AKO65_09380	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKO65_09385	COG0596	Alpha beta hydrolase
AKO65_09390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKO65_09395	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_09400	COG4948	Mandelate Racemase Muconate Lactonizing
AKO65_09410	COG1294	oxidase, subunit
AKO65_09415	COG1271	oxidase subunit
AKO65_09425	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO65_09425	COG3443	Belongs to the bacterial solute-binding protein 9 family
AKO65_09430	COG0288	reversible hydration of carbon dioxide
AKO65_09435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKO65_09440	COG1854	S-ribosylhomocysteine lyase activity
AKO65_09455	COG0783	Belongs to the Dps family
AKO65_09465	COG4824	toxin secretion phage lysis holin
AKO65_09480	COG2310	stress, protein
AKO65_09485	COG0494	nUDIX hydrolase
AKO65_09490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO65_09495	COG1116	anion transmembrane transporter activity
AKO65_09500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO65_09520	COG1233	COG1233 Phytoene dehydrogenase and related
AKO65_09525	COG1506	peptidase
AKO65_09535	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKO65_09540	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKO65_09545	COG0367	asparagine synthase
AKO65_09550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKO65_09555	COG2267	carboxylic ester hydrolase activity
AKO65_09565	COG4326	sporulation control protein
AKO65_09570	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AKO65_09575	COG1242	4 iron, 4 sulfur cluster binding
AKO65_09595	COG1725	Transcriptional regulator
AKO65_09600	COG1131	(ABC) transporter
AKO65_09610	COG1136	(ABC) transporter
AKO65_09615	COG0577	efflux transmembrane transporter activity
AKO65_09620	COG2433	Pfam Transposase IS66
AKO65_09625	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_09625	COG2202	Pas domain
AKO65_09635	COG0495	leucyl-tRNA aminoacylation
AKO65_09640	COG1073	alpha beta
AKO65_09645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO65_09650	COG0395	ABC-type sugar transport system, permease component
AKO65_09655	COG1653	transport
AKO65_09660	COG0656	L-ascorbic acid biosynthetic process
AKO65_09665	COG2814	Major facilitator Superfamily
AKO65_09670	COG1733	regulation of RNA biosynthetic process
AKO65_09675	COG2207	Transcriptional regulator
AKO65_09680	COG4209	transmembrane transport
AKO65_09685	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AKO65_09690	COG1653	transport
AKO65_09695	COG0673	inositol 2-dehydrogenase activity
AKO65_09700	COG5578	integral membrane protein
AKO65_09705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_09715	COG3196	Protein conserved in bacteria
AKO65_09720	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKO65_09730	COG2081	HI0933 family
AKO65_09735	COG2244	polysaccharide biosynthetic process
AKO65_09740	COG1187	pseudouridine synthase activity
AKO65_09745	COG1349	DNA-binding transcription factor activity
AKO65_09750	COG2252	PERMEase
AKO65_09755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO65_09760	COG3340	Belongs to the peptidase S51 family
AKO65_09765	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_09770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO65_09780	COG1597	lipid kinase activity
AKO65_09785	COG0510	thiamine kinase activity
AKO65_09795	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKO65_09800	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_09805	COG0281	malic enzyme
AKO65_09810	COG5584	Small secreted protein
AKO65_09815	COG1363	Peptidase, m42
AKO65_09830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_09835	COG4848	Belongs to the UPF0354 family
AKO65_09840	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_09845	COG1674	ftsk spoiiie
AKO65_09850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKO65_09855	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AKO65_09860	COG4980	gas vesicle protein
AKO65_09865	COG3118	belongs to the thioredoxin family
AKO65_09870	COG1605	Chorismate mutase
AKO65_09870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AKO65_09875	COG1609	Transcriptional regulator
AKO65_09880	COG0123	including yeast histone deacetylase and acetoin utilization protein
AKO65_09885	COG0517	IMP dehydrogenase activity
AKO65_09890	COG0454	-acetyltransferase
AKO65_09895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO65_09900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKO65_09905	COG2329	Antibiotic biosynthesis monooxygenase
AKO65_09910	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AKO65_09920	COG1335	isochorismatase
AKO65_09930	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKO65_09935	COG1956	GAF domain-containing protein
AKO65_09940	COG1309	transcriptional regulator
AKO65_09945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO65_09950	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AKO65_09955	COG1114	Component of the transport system for branched-chain amino acids
AKO65_09960	COG1114	Component of the transport system for branched-chain amino acids
AKO65_09965	COG1104	cysteine desulfurase activity
AKO65_09970	COG0301	tRNA thio-modification
AKO65_09980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO65_09985	COG1279	arginine transmembrane transporter activity
AKO65_10000	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO65_10005	COG0402	S-adenosylhomocysteine deaminase activity
AKO65_10010	COG0577	efflux transmembrane transporter activity
AKO65_10015	COG1136	(ABC) transporter
AKO65_10020	COG1695	Transcriptional regulator
AKO65_10025	COG0772	Belongs to the SEDS family
AKO65_10030	COG2205	protein histidine kinase activity
AKO65_10035	COG0745	RESPONSE REGULATOR receiver
AKO65_10040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO65_10045	COG2197	response regulator
AKO65_10050	COG4585	Histidine kinase
AKO65_10055	COG3239	Fatty acid desaturase
AKO65_10065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO65_10070	COG0616	signal peptide processing
AKO65_10075	COG1714	RDD family
AKO65_10085	COG3874	Sporulation protein YtfJ
AKO65_10090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AKO65_10095	COG0827	DNA restriction-modification system
AKO65_10100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKO65_10105	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKO65_10110	COG0137	argininosuccinate synthase activity
AKO65_10115	COG0165	Argininosuccinate lyase
AKO65_10125	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_10130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO65_10135	COG4109	DRTGG domain
AKO65_10145	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKO65_10165	COG0587	DNA-directed DNA polymerase activity
AKO65_10170	COG0281	malic enzyme
AKO65_10175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKO65_10180	COG0825	malonyl-CoA metabolic process
AKO65_10185	COG0205	6-phosphofructokinase activity
AKO65_10195	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKO65_10200	COG0628	permease
AKO65_10205	COG2707	UPF0756 membrane protein
AKO65_10210	COG0372	Belongs to the citrate synthase family
AKO65_10215	COG0538	isocitrate dehydrogenase activity
AKO65_10220	COG0039	L-malate dehydrogenase activity
AKO65_10225	COG0745	RESPONSE REGULATOR receiver
AKO65_10230	COG5002	protein histidine kinase activity
AKO65_10235	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO65_10235	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO65_10240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKO65_10245	COG1971	Probably functions as a manganese efflux pump
AKO65_10250	COG0237	dephospho-CoA kinase activity
AKO65_10255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO65_10260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKO65_10270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKO65_10275	COG3611	Membrane attachment protein
AKO65_10280	COG1484	DNA-dependent DNA replication
AKO65_10285	COG0398	Pfam SNARE associated Golgi protein
AKO65_10295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO65_10315	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKO65_10320	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKO65_10325	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKO65_10330	COG3326	Membrane
AKO65_10340	COG1363	Peptidase, m42
AKO65_10345	COG1966	Carbon starvation protein
AKO65_10355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO65_10360	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKO65_10365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_10365	COG0072	phenylalanine-tRNA ligase activity
AKO65_10370	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO65_10375	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AKO65_10380	COG1286	toxin biosynthetic process
AKO65_10385	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO65_10385	COG1796	DNA polymerase
AKO65_10390	COG1193	negative regulation of DNA recombination
AKO65_10395	COG3766	membrane
AKO65_10405	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_10410	COG1309	transcriptional regulator
AKO65_10415	COG1024	Enoyl-CoA hydratase
AKO65_10420	COG2086	electron transfer activity
AKO65_10425	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AKO65_10430	COG3534	alpha-L-arabinofuranosidase
AKO65_10435	COG3118	belongs to the thioredoxin family
AKO65_10440	COG0322	excinuclease ABC activity
AKO65_10445	COG0527	aspartate kinase activity
AKO65_10450	COG1719	4-vinyl reductase, 4VR
AKO65_10455	COG2009	succinate dehydrogenase
AKO65_10460	COG1053	succinate dehydrogenase
AKO65_10465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKO65_10470	COG0824	Thioesterase
AKO65_10475	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKO65_10475	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKO65_10480	COG2828	Protein conserved in bacteria
AKO65_10485	COG0583	DNA-binding transcription factor activity
AKO65_10490	COG2851	Citrate transporter
AKO65_10495	COG2197	response regulator
AKO65_10500	COG1846	Transcriptional regulator
AKO65_10505	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKO65_10510	COG5401	PFAM Sporulation and spore germination
AKO65_10515	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKO65_10520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKO65_10525	COG0622	Phosphoesterase
AKO65_10565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO65_10570	COG1696	Membrane protein involved in D-alanine export
AKO65_10575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO65_10580	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AKO65_10585	COG3339	Conserved Protein
AKO65_10590	COG2706	6-phosphogluconolactonase activity
AKO65_10595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_10600	COG0028	Belongs to the TPP enzyme family
AKO65_10605	COG0440	acetolactate synthase activity
AKO65_10610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKO65_10615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO65_10620	COG0473	3-isopropylmalate dehydrogenase activity
AKO65_10625	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKO65_10630	COG0066	3-isopropylmalate dehydratase activity
AKO65_10635	COG0457	Tetratricopeptide repeat
AKO65_10635	COG1477	protein flavinylation
AKO65_10640	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKO65_10645	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKO65_10650	COG0470	DNA polymerase III
AKO65_10650	COG1067	ATP-dependent peptidase activity
AKO65_10655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKO65_10660	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKO65_10680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO65_10685	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO65_10690	COG0181	hydroxymethylbilane synthase activity
AKO65_10695	COG1587	Uroporphyrinogen-III synthase
AKO65_10700	COG0113	porphobilinogen synthase activity
AKO65_10705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO65_10710	COG1388	LysM domain
AKO65_10715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO65_10725	COG0525	valine-tRNA ligase activity
AKO65_10730	COG0285	dihydrofolate synthase activity
AKO65_10735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKO65_10745	COG0424	maF-like protein
AKO65_10750	COG2003	Belongs to the UPF0758 family
AKO65_10755	COG1077	Cell shape determining protein MreB Mrl
AKO65_10760	COG1792	Involved in formation and maintenance of cell shape
AKO65_10765	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AKO65_10770	COG0850	regulation of cytokinetic process
AKO65_10775	COG2894	cell division
AKO65_10780	COG0739	heme binding
AKO65_10785	COG1994	Peptidase M50
AKO65_10790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKO65_10795	COG2868	ribosomal protein
AKO65_10800	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKO65_10805	COG3290	protein histidine kinase activity
AKO65_10810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKO65_10815	COG4492	Belongs to the UPF0735 family
AKO65_10820	COG0077	Prephenate dehydratase
AKO65_10825	COG1827	regulation of RNA biosynthetic process
AKO65_10830	COG1104	cysteine desulfurase activity
AKO65_10835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKO65_10840	COG0157	Belongs to the NadC ModD family
AKO65_10845	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKO65_10850	COG1388	LysM domain
AKO65_10865	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKO65_10875	COG2112	serine threonine protein kinase
AKO65_10885	COG0632	four-way junction helicase activity
AKO65_10890	COG2255	four-way junction helicase activity
AKO65_10900	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKO65_10905	COG0343	queuine tRNA-ribosyltransferase activity
AKO65_10910	COG1862	Preprotein translocase
AKO65_10920	COG2323	membrane
AKO65_10925	COG2244	polysaccharide biosynthetic process
AKO65_10935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO65_10935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO65_10940	COG0490	domain, Protein
AKO65_10945	COG5416	Lipopolysaccharide assembly protein A domain
AKO65_10950	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKO65_10950	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKO65_10955	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO65_10960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKO65_10965	COG1490	D-aminoacyl-tRNA deacylase activity
AKO65_10970	COG4991	sh3 domain protein
AKO65_10970	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_10970	COG3103	Sh3 type 3 domain protein
AKO65_10975	COG0124	histidyl-tRNA synthetase
AKO65_10985	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKO65_10990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKO65_10995	COG1959	2 iron, 2 sulfur cluster binding
AKO65_11000	COG1104	cysteine desulfurase activity
AKO65_11005	COG0482	sulfurtransferase activity
AKO65_11010	COG0457	Tetratricopeptide repeat
AKO65_11015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKO65_11020	COG3881	PFAM PRC-barrel domain
AKO65_11030	COG0765	amino acid transport
AKO65_11035	COG0765	amino acid transport
AKO65_11040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_11045	COG1126	abc transporter atp-binding protein
AKO65_11050	COG0628	permease
AKO65_11055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKO65_11060	COG4472	Bacterial protein of unknown function (DUF965)
AKO65_11065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKO65_11070	COG3906	Belongs to the UPF0473 family
AKO65_11080	COG1268	BioY protein
AKO65_11085	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_11090	COG0183	Belongs to the thiolase family
AKO65_11095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO65_11115	COG0572	uridine kinase
AKO65_11120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKO65_11125	COG0768	penicillin binding
AKO65_11140	COG2226	methyltransferase
AKO65_11145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKO65_11150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_11155	COG0626	cystathionine gamma-synthase activity
AKO65_11165	COG2226	methyltransferase
AKO65_11170	COG1063	alcohol dehydrogenase
AKO65_11175	COG0583	DNA-binding transcription factor activity
AKO65_11180	COG1115	amino acid carrier protein
AKO65_11190	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_11200	COG1063	alcohol dehydrogenase
AKO65_11210	COG0765	amino acid transport
AKO65_11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_11220	COG1126	abc transporter atp-binding protein
AKO65_11225	COG1960	acyl-CoA dehydrogenase activity
AKO65_11230	COG2602	Beta-lactamase
AKO65_11260	COG1733	regulation of RNA biosynthetic process
AKO65_11265	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AKO65_11270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AKO65_11280	COG1846	Transcriptional regulator
AKO65_11290	COG1609	Transcriptional regulator
AKO65_11305	COG2160	L-arabinose isomerase activity
AKO65_11330	COG1122	ATPase activity
AKO65_11365	COG0726	polysaccharide deacetylase
AKO65_11395	COG0457	Tetratricopeptide repeat
AKO65_11405	COG2755	lipolytic protein G-D-S-L family
AKO65_11415	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AKO65_11420	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO65_11425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO65_11430	COG1534	Rna-binding protein
AKO65_11435	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKO65_11440	COG1713	HD superfamily hydrolase involved in NAD metabolism
AKO65_11445	COG0799	negative regulation of ribosome biogenesis
AKO65_11450	COG2226	methyltransferase
AKO65_11455	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_11460	COG1555	photosystem II stabilization
AKO65_11460	COG1596	polysaccharide export
AKO65_11465	COG2131	deaminase
AKO65_11470	COG0658	competence protein
AKO65_11470	COG2333	competence protein COMEC
AKO65_11475	COG1466	dna polymerase III delta subunit
AKO65_11480	COG0268	Binds directly to 16S ribosomal RNA
AKO65_11485	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AKO65_11490	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_11500	COG0481	GTPase activity
AKO65_11505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO65_11510	COG1420	regulation of RNA biosynthetic process
AKO65_11515	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKO65_11520	COG0443	Heat shock 70 kDa protein
AKO65_11525	COG0484	heat shock protein binding
AKO65_11530	COG2264	protein methyltransferase activity
AKO65_11535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKO65_11540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO65_11545	COG1283	sodium-dependent phosphate transmembrane transporter activity
AKO65_11550	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AKO65_11555	COG1610	YqeY-like protein
AKO65_11560	COG1030	water channel activity
AKO65_11565	COG4864	UPF0365 protein
AKO65_11580	COG0561	phosphatase activity
AKO65_11585	COG1702	phosphate starvation-inducible protein PhoH
AKO65_11590	COG1480	7TM receptor with intracellular HD hydrolase
AKO65_11595	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKO65_11600	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKO65_11605	COG0295	cytidine deaminase activity
AKO65_11610	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKO65_11615	COG1381	Involved in DNA repair and RecF pathway recombination
AKO65_11620	COG0752	glycyl-tRNA synthetase alpha subunit
AKO65_11625	COG0751	glycine-tRNA ligase activity
AKO65_11630	COG0517	IMP dehydrogenase activity
AKO65_11635	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKO65_11640	COG1671	Belongs to the UPF0178 family
AKO65_11645	COG0358	DNA primase activity
AKO65_11650	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKO65_11655	COG2010	Cytochrome c
AKO65_11660	COG2384	SAM-dependent methyltransferase
AKO65_11665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKO65_11670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKO65_11680	COG0513	Belongs to the DEAD box helicase family
AKO65_11695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_11700	COG1121	(ABC) transporter
AKO65_11705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO65_11710	COG0735	belongs to the Fur family
AKO65_11715	COG1940	carbohydrate kinase activity
AKO65_11720	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AKO65_11725	COG4709	membrane
AKO65_11730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKO65_11735	COG1388	LysM domain
AKO65_11740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_11745	COG5521	maltodextrose utilization protein MalA
AKO65_11750	COG2839	Protein conserved in bacteria
AKO65_11755	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO65_11760	COG0477	Major facilitator Superfamily
AKO65_11770	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKO65_11775	COG0573	inorganic phosphate transmembrane transporter activity
AKO65_11780	COG0581	inorganic phosphate transmembrane transporter activity
AKO65_11785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO65_11790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO65_11795	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO65_11810	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO65_11815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKO65_11825	COG0705	Rhomboid family
AKO65_11825	COG0457	Tetratricopeptide repeat
AKO65_11830	COG4483	Protein conserved in bacteria
AKO65_11835	COG1940	carbohydrate kinase activity
AKO65_11840	COG1368	sulfuric ester hydrolase activity
AKO65_11845	COG2866	Carboxypeptidase
AKO65_11850	COG2814	Major facilitator Superfamily
AKO65_11855	COG0011	TIGRFAM Protein of
AKO65_11860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_11870	COG1393	Belongs to the ArsC family
AKO65_11880	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_11885	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKO65_11890	COG1459	type II secretion system
AKO65_11895	COG4537	Required for transformation and DNA binding
AKO65_11900	COG4970	Tfp pilus assembly protein FimT
AKO65_11935	COG0681	Belongs to the peptidase S26 family
AKO65_11955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO65_11960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKO65_11965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO65_11970	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO65_11975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO65_11980	COG0095	Lipoate-protein ligase
AKO65_11985	COG1321	iron dependent repressor
AKO65_11990	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO65_12000	COG3872	metal-dependent enzyme
AKO65_12010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKO65_12015	COG0006	proline dipeptidase activity
AKO65_12020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKO65_12030	COG3854	ATPases associated with a variety of cellular activities
AKO65_12070	COG0511	ligase activity, forming carbon-carbon bonds
AKO65_12075	COG0439	Biotin carboxylase
AKO65_12080	COG1302	Protein conserved in bacteria
AKO65_12085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO65_12090	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKO65_12095	COG1570	exodeoxyribonuclease VII activity
AKO65_12100	COG1722	exodeoxyribonuclease VII activity
AKO65_12105	COG0142	geranyltranstransferase activity
AKO65_12110	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKO65_12115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKO65_12120	COG1438	arginine binding
AKO65_12125	COG0497	DNA recombination
AKO65_12130	COG0750	zinc metalloprotease
AKO65_12135	COG0745	RESPONSE REGULATOR receiver
AKO65_12140	COG0457	Tetratricopeptide repeat
AKO65_12145	COG0584	glycerophosphoryl diester phosphodiesterase
AKO65_12155	COG3829	transcription factor binding
AKO65_12155	COG3290	protein histidine kinase activity
AKO65_12160	COG0280	phosphate acetyltransferase
AKO65_12170	COG3426	butyrate kinase activity
AKO65_12175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO65_12180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO65_12185	COG0022	dehydrogenase e1 component
AKO65_12190	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_12200	COG1597	lipid kinase activity
AKO65_12210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO65_12215	COG0765	amino acid transport
AKO65_12220	COG1126	abc transporter atp-binding protein
AKO65_12225	COG4129	membrane
AKO65_12230	COG1376	ErfK ybiS ycfS ynhG family protein
AKO65_12235	COG0346	lactoylglutathione lyase activity
AKO65_12240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO65_12245	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO65_12250	COG0835	chemotaxis
AKO65_12255	COG0706	membrane insertase activity
AKO65_12265	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO65_12270	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKO65_12280	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_12290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_12295	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO65_12300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO65_12305	COG2723	6-phospho-beta-galactosidase activity
AKO65_12310	COG2188	Transcriptional regulator
AKO65_12315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKO65_12325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_12330	COG0596	Alpha beta hydrolase
AKO65_12335	COG1902	pentaerythritol trinitrate reductase activity
AKO65_12340	COG4187	Peptidase family M20/M25/M40
AKO65_12350	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_12355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_12360	COG0300	oxidoreductase activity
AKO65_12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKO65_12375	COG1072	(Pantothenic acid kinase))
AKO65_12380	COG2211	Major facilitator Superfamily
AKO65_12390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO65_12400	COG0456	acetyltransferase
AKO65_12405	COG0456	acetyltransferase
AKO65_12405	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO65_12410	COG4305	rare lipoprotein A
AKO65_12415	COG4918	Iron-sulphur cluster biosynthesis
AKO65_12425	COG0457	Tetratricopeptide repeat
AKO65_12430	COG1073	alpha beta
AKO65_12445	COG0667	Aldo Keto reductase
AKO65_12450	COG0494	nUDIX hydrolase
AKO65_12455	COG1379	DNA repair
AKO65_12460	COG2153	protein acetylation
AKO65_12470	COG1404	Belongs to the peptidase S8 family
AKO65_12475	COG1300	Membrane
AKO65_12480	COG0735	belongs to the Fur family
AKO65_12490	COG4974	Belongs to the 'phage' integrase family
AKO65_12495	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AKO65_12500	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKO65_12505	COG1686	Belongs to the peptidase S11 family
AKO65_12515	COG2172	sigma factor antagonist activity
AKO65_12520	COG1191	sigma factor activity
AKO65_12540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO65_12555	COG0697	spore germination
AKO65_12560	COG0019	diaminopimelate decarboxylase activity
AKO65_12565	COG4086	secreted protein
AKO65_12570	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKO65_12575	COG2814	Major facilitator Superfamily
AKO65_12595	COG0307	riboflavin synthase, alpha
AKO65_12605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKO65_12610	COG0456	acetyltransferase
AKO65_12615	COG1547	Domain of unknown function (DUF309)
AKO65_12620	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKO65_12625	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKO65_12635	COG1686	Belongs to the peptidase S11 family
AKO65_12640	COG2715	membrane protein required for spore maturation
AKO65_12645	COG0700	Nucleoside recognition
AKO65_12650	COG1187	pseudouridine synthase activity
AKO65_12655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_12660	COG1333	cytochrome c biogenesis protein
AKO65_12665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO65_12670	COG0745	RESPONSE REGULATOR receiver
AKO65_12675	COG5002	protein histidine kinase activity
AKO65_12680	COG1595	DNA-templated transcription, initiation
AKO65_12695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKO65_12700	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AKO65_12705	COG1141	Ferredoxin
AKO65_12710	COG4955	Helix-turn-helix domain
AKO65_12715	COG0514	ATP-dependent DNA helicase (RecQ)
AKO65_12720	COG1266	CAAX protease self-immunity
AKO65_12725	COG1388	LysM domain
AKO65_12735	COG1408	metallophosphoesterase
AKO65_12740	COG4862	establishment of competence for transformation
AKO65_12745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO65_12750	COG0492	ferredoxin-NADP+ reductase activity
AKO65_12755	COG2339	peptidase activity
AKO65_12760	COG3773	Cell wall hydrolase
AKO65_12760	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_12765	COG2959	enzyme of heme biosynthesis
AKO65_12770	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AKO65_12780	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKO65_12785	COG0539	negative regulation of cytoplasmic translation
AKO65_12790	COG1304	FMN binding
AKO65_12810	COG1160	GTP binding
AKO65_12815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKO65_12830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO65_12835	COG0776	regulation of translation
AKO65_12840	COG0302	gtp cyclohydrolase
AKO65_12850	COG0142	geranyltranstransferase activity
AKO65_12855	COG2226	methyltransferase
AKO65_12860	COG0142	geranyltranstransferase activity
AKO65_12865	COG0105	UTP biosynthetic process
AKO65_12870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKO65_12875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKO65_12880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKO65_12885	COG4401	Chorismate mutase type I
AKO65_12895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKO65_12900	COG0134	indole-3-glycerol-phosphate synthase activity
AKO65_12905	COG0135	phosphoribosylanthranilate isomerase activity
AKO65_12910	COG0133	tryptophan synthase activity
AKO65_12915	COG0159	tryptophan synthase activity
AKO65_12920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKO65_12925	COG0287	Prephenate dehydrogenase
AKO65_12930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKO65_12935	COG0457	Tetratricopeptide repeat
AKO65_12940	COG5582	Belongs to the UPF0302 family
AKO65_12950	COG0723	plastoquinol--plastocyanin reductase activity
AKO65_12955	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO65_12960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO65_12960	COG2010	Cytochrome c
AKO65_12965	COG4347	Protein of unknown function (DUF1405)
AKO65_12975	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_12980	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO65_12985	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKO65_12990	COG1803	Methylglyoxal synthase
AKO65_12995	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO65_13000	COG0438	transferase activity, transferring glycosyl groups
AKO65_13005	COG0617	tRNA 3'-terminal CCA addition
AKO65_13015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKO65_13020	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKO65_13025	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKO65_13030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKO65_13030	COG1199	ATP-dependent helicase activity
AKO65_13035	COG5353	protein conserved in bacteria
AKO65_13040	COG0017	Asparaginyl-tRNA synthetase
AKO65_13045	COG3935	DnaD domain protein
AKO65_13050	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKO65_13060	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO65_13060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_13065	COG3331	DNA recombination
AKO65_13095	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO65_13100	COG2190	(PTS) system
AKO65_13105	COG1902	pentaerythritol trinitrate reductase activity
AKO65_13215	COG1802	Transcriptional regulator
AKO65_13215	COG4626	Terminase
AKO65_13295	COG3942	CHAP domain
AKO65_13295	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO65_13320	COG4824	toxin secretion phage lysis holin
AKO65_13325	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO65_13345	COG0457	Tetratricopeptide repeat
AKO65_13360	COG1111	helicase
AKO65_13360	COG1205	dead DEAH box helicase
AKO65_13365	COG3359	exonuclease
AKO65_13370	COG4474	Belongs to the UPF0398 family
AKO65_13375	COG3599	regulation of cell shape
AKO65_13380	COG0116	Belongs to the methyltransferase superfamily
AKO65_13390	COG1199	ATP-dependent helicase activity
AKO65_13395	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AKO65_13400	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO65_13405	COG2233	PERMEase
AKO65_13410	COG0726	polysaccharide deacetylase
AKO65_13415	COG0456	acetyltransferase
AKO65_13415	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO65_13420	COG3424	synthase
AKO65_13425	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKO65_13430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO65_13440	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO65_13450	COG0328	RNA-DNA hybrid ribonuclease activity
AKO65_13455	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKO65_13460	COG0328	RNA-DNA hybrid ribonuclease activity
AKO65_13475	COG1278	Cold shock
AKO65_13485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO65_13490	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AKO65_13495	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKO65_13500	COG0386	Belongs to the glutathione peroxidase family
AKO65_13505	COG1418	mRNA catabolic process
AKO65_13510	COG1413	lyase activity
AKO65_13515	COG0129	dihydroxy-acid dehydratase activity
AKO65_13525	COG2136	Putative SAM-dependent methyltransferase
AKO65_13525	COG2521	methyltransferase
AKO65_13535	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO65_13540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKO65_13545	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO65_13550	COG0204	Acyl-transferase
AKO65_13555	COG1272	protein, Hemolysin III
AKO65_13560	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AKO65_13565	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKO65_13580	COG1999	signal sequence binding
AKO65_13585	COG2755	lipolytic protein G-D-S-L family
AKO65_13590	COG4698	Protein conserved in bacteria
AKO65_13610	COG1846	Transcriptional regulator
AKO65_13615	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO65_13620	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO65_13625	COG1086	Polysaccharide biosynthesis protein
AKO65_13635	COG4641	Protein conserved in bacteria
AKO65_13650	COG0463	Glycosyl transferase, family 2
AKO65_13655	COG3829	transcription factor binding
AKO65_13660	COG1509	lysine 2,3-aminomutase activity
AKO65_13670	COG4479	Belongs to the UPF0346 family
AKO65_13680	COG0671	phosphoesterase, PA-phosphatase related
AKO65_13690	COG0813	purine-nucleoside phosphorylase activity
AKO65_13695	COG1876	peptidase activity
AKO65_13705	COG2226	methyltransferase
AKO65_13710	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_13710	COG0793	Belongs to the peptidase S41A family
AKO65_13715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO65_13725	COG0778	Nitroreductase
AKO65_13730	COG1733	regulation of RNA biosynthetic process
AKO65_13745	COG2962	Rard protein
AKO65_13755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO65_13760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO65_13765	COG0534	Mate efflux family protein
AKO65_13770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO65_13775	COG1388	LysM domain
AKO65_13775	COG0791	NLP P60 protein
AKO65_13780	COG2032	superoxide dismutase activity
AKO65_13785	COG0714	Associated with various cellular activities
AKO65_13790	COG4548	von Willebrand factor, type A
AKO65_13795	COG0567	Dehydrogenase, E1 component
AKO65_13800	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_13805	COG0385	Bile acid
AKO65_13810	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO65_13815	COG1657	PFAM Prenyltransferase squalene oxidase
AKO65_13825	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_13845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO65_13850	COG0514	ATP-dependent DNA helicase (RecQ)
AKO65_13855	COG1388	LysM domain
AKO65_13855	COG3584	3D domain protein
AKO65_13865	COG2322	membrane
AKO65_13870	COG0372	Belongs to the citrate synthase family
AKO65_13875	COG2079	MmgE PrpD family protein
AKO65_13880	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKO65_13885	COG0741	lytic transglycosylase activity
AKO65_13890	COG0531	amino acid
AKO65_13895	COG0640	Transcriptional regulator
AKO65_13905	COG2378	regulation of single-species biofilm formation
AKO65_13910	COG3708	Transcriptional regulator
AKO65_13915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO65_13920	COG1309	transcriptional regulator
AKO65_13940	COG1994	Peptidase M50
AKO65_13945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO65_13950	COG2211	Major facilitator Superfamily
AKO65_13960	COG1940	carbohydrate kinase activity
AKO65_13965	COG2115	Belongs to the xylose isomerase family
AKO65_13970	COG1070	Carbohydrate kinase
AKO65_13980	COG0243	molybdopterin cofactor binding
AKO65_13990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_13995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO65_14000	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO65_14005	COG0454	-acetyltransferase
AKO65_14010	COG0789	Transcriptional regulator
AKO65_14010	COG4978	Transcriptional regulator
AKO65_14015	COG1132	(ABC) transporter
AKO65_14025	COG0583	DNA-binding transcription factor activity
AKO65_14030	COG0070	glutamate synthase
AKO65_14030	COG0067	glutamate synthase
AKO65_14030	COG0069	glutamate synthase activity
AKO65_14035	COG0493	'glutamate synthase
AKO65_14040	COG2223	nitrite transmembrane transporter activity
AKO65_14045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO65_14050	COG0243	molybdopterin cofactor binding
AKO65_14055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO65_14060	COG2146	nitrite reductase [NAD(P)H] activity
AKO65_14065	COG2323	membrane
AKO65_14070	COG4677	pectinesterase activity
AKO65_14075	COG2027	D-alanyl-D-alanine carboxypeptidase
AKO65_14080	COG0534	Mate efflux family protein
AKO65_14100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO65_14110	COG1587	Uroporphyrinogen-III synthase
AKO65_14115	COG0586	Pfam SNARE associated Golgi protein
AKO65_14120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO65_14125	COG2246	polysaccharide biosynthetic process
AKO65_14130	COG0166	Belongs to the GPI family
AKO65_14150	COG0247	lactate metabolic process
AKO65_14155	COG0277	FAD linked oxidase domain protein
AKO65_14160	COG3835	regulator
AKO65_14170	COG1942	4-Oxalocrotonate Tautomerase
AKO65_14175	COG1349	DNA-binding transcription factor activity
AKO65_14185	COG1649	PFAM Uncharacterised BCR, COG1649
AKO65_14190	COG1960	acyl-CoA dehydrogenase activity
AKO65_14195	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_14200	COG0439	Biotin carboxylase
AKO65_14205	COG0511	ligase activity, forming carbon-carbon bonds
AKO65_14210	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO65_14215	COG1024	Enoyl-CoA hydratase
AKO65_14220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO65_14230	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO65_14235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO65_14240	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_14260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_14270	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO65_14275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_14275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_14275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_14280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_14280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_14280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_14290	COG2814	Major facilitator Superfamily
AKO65_14295	COG1846	Transcriptional regulator
AKO65_14300	COG5444	nuclease activity
AKO65_14330	COG1783	phage Terminase large subunit
AKO65_14335	COG5518	Phage portal protein
AKO65_14340	COG2369	cell adhesion
AKO65_14355	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_14370	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO65_14395	COG1486	melibiose metabolic process
AKO65_14400	COG1012	belongs to the aldehyde dehydrogenase family
AKO65_14405	COG3507	Belongs to the glycosyl hydrolase 43 family
AKO65_14415	COG0745	RESPONSE REGULATOR receiver
AKO65_14420	COG2205	protein histidine kinase activity
AKO65_14435	COG2190	(PTS) system
AKO65_14435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_14435	COG1263	PTS System
AKO65_14440	COG2723	6-phospho-beta-galactosidase activity
AKO65_14445	COG0789	Transcriptional regulator
AKO65_14450	COG0657	acetylesterase activity
AKO65_14490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO65_14500	COG0640	Transcriptional regulator
AKO65_14505	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO65_14510	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO65_14515	COG0110	maltose O-acetyltransferase activity
AKO65_14520	COG0473	3-isopropylmalate dehydrogenase activity
AKO65_14525	COG0738	Major facilitator superfamily
AKO65_14535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO65_14540	COG0187	DNA topoisomerase II activity
AKO65_14545	COG1832	CoA-binding protein
AKO65_14550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKO65_14555	COG4841	protein insertion into membrane
AKO65_14565	COG0824	Thioesterase
AKO65_14580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_14585	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKO65_14600	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO65_14610	COG4846	Membrane protein involved in cytochrome C biogenesis
AKO65_14615	COG0785	Cytochrome C biogenesis protein
AKO65_14625	COG3763	UPF0154 protein
AKO65_14635	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKO65_14640	COG4224	UPF0291 protein
AKO65_14645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AKO65_14650	COG1388	LysM domain
AKO65_14655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKO65_14670	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO65_14675	COG3209	COG3209 Rhs family protein
AKO65_14680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO65_14685	COG3591	Belongs to the peptidase S1B family
AKO65_14690	COG2124	cytochrome p450
AKO65_14690	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO65_14695	COG1309	transcriptional regulator
AKO65_14700	COG2323	membrane
AKO65_14720	COG1556	Lactate utilization protein
AKO65_14725	COG1139	Iron-sulfur cluster binding protein
AKO65_14730	COG0247	lactate metabolic process
AKO65_14740	COG0702	epimerase
AKO65_14745	COG1959	2 iron, 2 sulfur cluster binding
AKO65_14755	COG4876	unkown
AKO65_14760	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AKO65_14765	COG1793	dna ligase
AKO65_14765	COG3285	dna ligase
AKO65_14770	COG3619	membrane
AKO65_14780	COG0457	Tetratricopeptide repeat
AKO65_14805	COG5646	InterPro IPR014922
AKO65_14830	COG5444	nuclease activity
AKO65_14850	COG0604	alcohol dehydrogenase
AKO65_14865	COG0457	Tetratricopeptide repeat
AKO65_14895	COG0174	glutamine synthetase
AKO65_14900	COG0789	Transcriptional regulator
AKO65_14905	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AKO65_14910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKO65_14915	COG0464	growth
AKO65_14925	COG4112	unkown
AKO65_14930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO65_14935	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO65_14940	COG1780	Probably involved in ribonucleotide reductase function
AKO65_14955	COG1923	regulation of RNA biosynthetic process
AKO65_14960	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKO65_14985	COG2076	Multidrug Resistance protein
AKO65_14990	COG1764	response to oxidative stress
AKO65_14995	COG4195	phage-related replication protein
AKO65_15000	COG1404	Belongs to the peptidase S8 family
AKO65_15005	COG0457	Tetratricopeptide repeat
AKO65_15010	COG4195	phage-related replication protein
AKO65_15015	COG1329	Transcriptional regulator
AKO65_15035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKO65_15040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKO65_15050	COG4550	Control of competence regulator ComK, YlbF/YmcA
AKO65_15055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO65_15065	COG0156	8-amino-7-oxononanoate synthase activity
AKO65_15070	COG1063	alcohol dehydrogenase
AKO65_15075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO65_15080	COG2359	stage V sporulation protein S
AKO65_15085	COG1692	metallophosphoesterase
AKO65_15090	COG1418	mRNA catabolic process
AKO65_15095	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKO65_15100	COG1058	Belongs to the CinA family
AKO65_15100	COG1546	Belongs to the CinA family
AKO65_15105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKO65_15110	COG1426	Protein conserved in bacteria
AKO65_15125	COG0300	oxidoreductase activity
AKO65_15130	COG1033	growth of symbiont in host cell
AKO65_15130	COG2409	Drug exporters of the RND superfamily
AKO65_15140	COG0612	Peptidase, M16
AKO65_15145	COG0612	Peptidase, M16
AKO65_15150	COG1033	growth of symbiont in host cell
AKO65_15150	COG2409	Drug exporters of the RND superfamily
AKO65_15155	COG2814	Major facilitator Superfamily
AKO65_15160	COG2188	Transcriptional regulator
AKO65_15165	COG4980	gas vesicle protein
AKO65_15165	COG1674	ftsk spoiiie
AKO65_15175	COG0740	serine-type endopeptidase activity
AKO65_15180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO65_15190	COG0527	aspartate kinase activity
AKO65_15195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKO65_15200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO65_15205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO65_15210	COG1873	PFAM PRC-barrel domain
AKO65_15215	COG0367	asparagine synthase
AKO65_15260	COG1260	myo-inositol-1-phosphate synthase
AKO65_15265	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO65_15270	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_15275	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_15295	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AKO65_15330	COG1132	(ABC) transporter
AKO65_15335	COG1132	(ABC) transporter
AKO65_15350	COG0612	Peptidase, M16
AKO65_15355	COG0726	polysaccharide deacetylase
AKO65_15360	COG1185	polyribonucleotide nucleotidyltransferase activity
AKO65_15365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKO65_15370	COG0196	riboflavin kinase activity
AKO65_15375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKO65_15380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKO65_15385	COG1550	Protein conserved in bacteria
AKO65_15390	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKO65_15395	COG1358	cellular component organization or biogenesis
AKO65_15400	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AKO65_15405	COG0195	Participates in both transcription termination and antitermination
AKO65_15410	COG0779	Required for maturation of 30S ribosomal subunits
AKO65_15435	COG2176	DNA-directed DNA polymerase activity
AKO65_15440	COG0442	prolyl-tRNA aminoacylation
AKO65_15445	COG0750	zinc metalloprotease
AKO65_15450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKO65_15455	COG4589	Belongs to the CDS family
AKO65_15460	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKO65_15465	COG0233	cytoplasmic translational termination
AKO65_15470	COG0528	UMP kinase activity
AKO65_15475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKO65_15490	COG1191	sigma factor activity
AKO65_15500	COG1776	CheC inhibitor of MCP methylation
AKO65_15505	COG0835	chemotaxis
AKO65_15510	COG0643	Histidine kinase
AKO65_15510	COG2198	Histidine kinase
AKO65_15515	COG2201	protein-glutamate methylesterase activity
AKO65_15520	COG0455	bacterial-type flagellum organization
AKO65_15525	COG1419	protein localization to endoplasmic reticulum
AKO65_15530	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO65_15535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO65_15540	COG1684	flagellar biosynthetic protein fliR
AKO65_15545	COG1987	bacterial-type flagellum assembly
AKO65_15550	COG1338	Plays a role in the flagellum-specific transport system
AKO65_15555	COG3190	flagellar
AKO65_15560	COG2201	protein-glutamate methylesterase activity
AKO65_15565	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO65_15565	COG1776	CheC inhibitor of MCP methylation
AKO65_15570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO65_15575	COG1580	Controls the rotational direction of flagella during chemotaxis
AKO65_15580	COG1582	Flagellar protein (FlbD)
AKO65_15585	COG4786	Flagellar basal body rod
AKO65_15590	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AKO65_15595	COG3144	bacterial-type flagellum assembly
AKO65_15600	COG3334	PFAM MgtE intracellular
AKO65_15605	COG2882	bacterial-type flagellum organization
AKO65_15610	COG1157	protein secretion by the type III secretion system
AKO65_15615	COG1317	bacterial-type flagellum organization
AKO65_15620	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO65_15625	COG1766	The M ring may be actively involved in energy transduction
AKO65_15630	COG1677	Flagellar hook-basal body complex protein FliE
AKO65_15635	COG1558	bacterial-type flagellum-dependent cell motility
AKO65_15640	COG1815	bacterial-type flagellum-dependent cell motility
AKO65_15645	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO65_15650	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKO65_15655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKO65_15660	COG4974	Belongs to the 'phage' integrase family
AKO65_15665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AKO65_15670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO65_15675	COG0758	DNA mediated transformation
AKO65_15680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKO65_15685	COG0045	succinate-CoA ligase (ADP-forming) activity
AKO65_15690	COG2257	FlhB HrpN YscU SpaS Family
AKO65_15700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO65_15705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO65_15710	COG0335	large ribosomal subunit rRNA binding
AKO65_15715	COG0336	Belongs to the RNA methyltransferase TrmD family
AKO65_15720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKO65_15730	COG1837	Belongs to the UPF0109 family
AKO65_15735	COG0228	four-way junction DNA binding
AKO65_15740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKO65_15745	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AKO65_15750	COG0552	protein localization to endoplasmic reticulum
AKO65_15755	COG1196	nuclear chromosome segregation
AKO65_15765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO65_15770	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_15775	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKO65_15780	COG0416	fatty acid biosynthetic process
AKO65_15785	COG1349	DNA-binding transcription factor activity
AKO65_15790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKO65_15795	COG1760	l-serine dehydratase
AKO65_15800	COG1760	l-serine dehydratase
AKO65_15805	COG1461	Dihydroxyacetone kinase
AKO65_15810	COG1302	Protein conserved in bacteria
AKO65_15815	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKO65_15825	COG1564	THIamine pyrophosphokinase
AKO65_15830	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO65_15835	COG1162	GTPase activity
AKO65_15840	COG0515	serine threonine protein kinase
AKO65_15840	COG2815	serine threonine protein kinase
AKO65_15845	COG0631	protein serine/threonine phosphatase activity
AKO65_15850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKO65_15855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO65_15855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKO65_15860	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKO65_15865	COG0242	peptide deformylase activity
AKO65_15870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKO65_15875	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO65_15880	COG1758	RNA polymerase activity
AKO65_15885	COG0194	GDP metabolic process
AKO65_15890	COG2052	Domain of unknown function (DUF370)
AKO65_15895	COG1561	YicC-like family, N-terminal region
AKO65_15900	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKO65_15910	COG1648	precorrin-2 dehydrogenase activity
AKO65_15915	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AKO65_15920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKO65_15925	COG0529	Catalyzes the synthesis of activated sulfate
AKO65_15930	COG2046	Belongs to the sulfate adenylyltransferase family
AKO65_15935	COG0306	phosphate transporter
AKO65_15940	COG0175	sulfate reduction
AKO65_15945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKO65_15950	COG0284	orotidine-5'-phosphate decarboxylase activity
AKO65_15955	COG0167	dihydroorotate dehydrogenase activity
AKO65_15960	COG0543	2 iron, 2 sulfur cluster binding
AKO65_15965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO65_15970	COG0505	Belongs to the CarA family
AKO65_15975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKO65_15980	COG0540	Belongs to the ATCase OTCase family
AKO65_15985	COG2233	PERMEase
AKO65_15990	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKO65_15995	COG0564	pseudouridine synthase activity
AKO65_16000	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKO65_16005	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO65_16010	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKO65_16015	COG3599	regulation of cell shape
AKO65_16020	COG2302	S4 RNA-binding domain
AKO65_16025	COG0762	integral membrane protein
AKO65_16030	COG1799	cell septum assembly
AKO65_16035	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKO65_16045	COG1873	PFAM PRC-barrel domain
AKO65_16050	COG1119	ATPase activity
AKO65_16060	COG3732	PTS system glucitol sorbitol-specific
AKO65_16065	COG3730	PTS system glucitol sorbitol-specific
AKO65_16080	COG2390	Transcriptional regulator
AKO65_16085	COG1191	sigma factor activity
AKO65_16090	COG1191	sigma factor activity
AKO65_16100	COG4412	M6 family metalloprotease domain protein
AKO65_16100	COG1404	Belongs to the peptidase S8 family
AKO65_16105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKO65_16110	COG0849	cell division
AKO65_16115	COG3856	small basic protein
AKO65_16120	COG3879	Bacterial protein of unknown function (DUF881)
AKO65_16125	COG3879	Bacterial protein of unknown function (DUF881)
AKO65_16130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKO65_16135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKO65_16140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO65_16145	COG0772	Belongs to the SEDS family
AKO65_16150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO65_16155	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO65_16160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKO65_16165	COG0768	penicillin binding
AKO65_16175	COG4839	cell division protein FtsL
AKO65_16180	COG0275	rRNA processing
AKO65_16185	COG2001	Belongs to the MraZ family
AKO65_16190	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AKO65_16195	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKO65_16200	COG0454	-acetyltransferase
AKO65_16210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKO65_16215	COG1399	metal-binding, possibly nucleic acid-binding protein
AKO65_16225	COG3480	Lon protease (S16) C-terminal proteolytic domain
AKO65_16230	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO65_16235	COG3314	Sporulation integral membrane protein YlbJ
AKO65_16240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKO65_16245	COG0742	ribosomal rna small subunit methyltransferase
AKO65_16250	COG4471	UPF0298 protein
AKO65_16255	COG3679	Belongs to the UPF0342 family
AKO65_16275	COG2340	Cysteine-rich secretory protein family
AKO65_16280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AKO65_16290	COG3336	cytochrome c oxidase
AKO65_16295	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO65_16300	COG1845	cytochrome c oxidase, subunit III
AKO65_16305	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO65_16310	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO65_16310	COG2010	Cytochrome c
AKO65_16315	COG0109	protoheme IX farnesyltransferase activity
AKO65_16320	COG1612	heme a metabolic process
AKO65_16330	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKO65_16335	COG0772	Belongs to the SEDS family
AKO65_16340	COG4838	Belongs to the UPF0358 family
AKO65_16345	COG2066	Belongs to the glutaminase family
AKO65_16350	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKO65_16355	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKO65_16365	COG4896	Protein conserved in bacteria
AKO65_16405	COG0483	inositol monophosphate 1-phosphatase activity
AKO65_16415	COG4493	Belongs to the UPF0637 family
AKO65_16420	COG4476	Belongs to the UPF0223 family
AKO65_16425	COG1982	Orn Lys Arg decarboxylase major
AKO65_16430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_16435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO65_16440	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_16445	COG0022	dehydrogenase e1 component
AKO65_16450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO65_16465	COG0242	peptide deformylase activity
AKO65_16470	COG0561	phosphatase activity
AKO65_16480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO65_16485	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO65_16490	COG0569	domain protein
AKO65_16495	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AKO65_16495	COG2105	PFAM AIG2 family protein
AKO65_16500	COG3852	Histidine kinase
AKO65_16505	COG2002	toxin-antitoxin pair type II binding
AKO65_16510	COG1077	Cell shape determining protein MreB Mrl
AKO65_16515	COG2309	aminopeptidase activity
AKO65_16525	COG0488	(ABC) transporter
AKO65_16535	COG0681	Belongs to the peptidase S26 family
AKO65_16540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_16540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_16540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO65_16545	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO65_16550	COG1349	DNA-binding transcription factor activity
AKO65_16555	COG0577	efflux transmembrane transporter activity
AKO65_16560	COG1136	(ABC) transporter
AKO65_16565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKO65_16580	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKO65_16585	COG0314	molybdopterin synthase activity
AKO65_16590	COG1763	Mo-molybdopterin cofactor biosynthetic process
AKO65_16595	COG0303	'Molybdopterin
AKO65_16600	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO65_16605	COG0746	molybdenum cofactor guanylyltransferase activity
AKO65_16620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_16625	COG0450	alkyl hydroperoxide reductase
AKO65_16630	COG0668	transmembrane transport
AKO65_16640	COG1473	amidohydrolase
AKO65_16645	COG2171	N-acyltransferase activity
AKO65_16650	COG0716	FMN binding
AKO65_16660	COG0716	FMN binding
AKO65_16670	COG0583	DNA-binding transcription factor activity
AKO65_16675	COG0517	IMP dehydrogenase activity
AKO65_16685	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AKO65_16690	COG4703	Protein of unknown function (DUF1797)
AKO65_16695	COG3546	catalase activity
AKO65_16700	COG2200	EAL domain
AKO65_16705	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_16710	COG1408	metallophosphoesterase
AKO65_16715	COG1376	ErfK ybiS ycfS ynhG family protein
AKO65_16720	COG2814	Major facilitator Superfamily
AKO65_16740	COG0784	Response regulator, receiver
AKO65_16740	COG0835	chemotaxis
AKO65_16750	COG1714	RDD family
AKO65_16755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO65_16760	COG0436	Aminotransferase
AKO65_16765	COG4191	Histidine kinase
AKO65_16770	COG0768	penicillin binding
AKO65_16775	COG2340	Cysteine-rich secretory protein family
AKO65_16780	COG2084	Dehydrogenase
AKO65_16790	COG0840	transmembrane signaling receptor activity
AKO65_16795	COG1533	DNA photolyase activity
AKO65_16805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKO65_16810	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO65_16815	COG2190	(PTS) system
AKO65_16815	COG1263	PTS System
AKO65_16815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO65_16820	COG3711	transcriptional antiterminator
AKO65_16825	COG1609	Transcriptional regulator
AKO65_16830	COG0006	proline dipeptidase activity
AKO65_16835	COG2217	Heavy metal translocating P-type atpase
AKO65_16840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO65_16845	COG2244	polysaccharide biosynthetic process
AKO65_16850	COG3773	Cell wall hydrolase
AKO65_16860	COG4873	Protein conserved in bacteria
AKO65_16870	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKO65_16875	COG0602	queuosine metabolic process
AKO65_16880	COG0720	synthase
AKO65_16885	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKO65_16890	COG3949	Membrane
AKO65_16895	COG0542	response to heat
AKO65_16900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKO65_16905	COG1360	Flagellar Motor Protein
AKO65_16910	COG1846	Transcriptional regulator
AKO65_16915	COG3852	Histidine kinase
AKO65_16925	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AKO65_16930	COG0235	Class ii aldolase
AKO65_16935	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AKO65_16940	COG1850	ribulose-bisphosphate carboxylase activity
AKO65_16945	COG0436	Aminotransferase
AKO65_16950	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AKO65_16955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKO65_16960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKO65_16965	COG5002	protein histidine kinase activity
AKO65_16970	COG3594	Acyltransferase
AKO65_16980	COG2323	membrane
AKO65_16985	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKO65_16990	COG0501	Belongs to the peptidase M48B family
AKO65_17010	COG1191	sigma factor activity
AKO65_17015	COG0861	Integral membrane protein TerC family
AKO65_17020	COG0586	Pfam SNARE associated Golgi protein
AKO65_17025	COG3300	MHYT domain
AKO65_17025	COG5001	Diguanylate cyclase
AKO65_17030	COG1846	Transcriptional regulator
AKO65_17045	COG0789	Transcriptional regulator
AKO65_17055	COG0583	DNA-binding transcription factor activity
AKO65_17065	COG2239	Acts as a magnesium transporter
AKO65_17075	COG3212	peptidase
AKO65_17080	COG3212	peptidase
AKO65_17085	COG5002	protein histidine kinase activity
AKO65_17085	COG3850	Histidine kinase
AKO65_17090	COG0745	RESPONSE REGULATOR receiver
AKO65_17105	COG1404	Belongs to the peptidase S8 family
AKO65_17110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO65_17115	COG0590	tRNA wobble adenosine to inosine editing
AKO65_17120	COG1764	response to oxidative stress
AKO65_17125	COG1846	Transcriptional regulator
AKO65_17130	COG1764	response to oxidative stress
AKO65_17140	COG0457	Tetratricopeptide repeat
AKO65_17145	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO65_17150	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO65_17155	COG0788	formyltetrahydrofolate deformylase activity
AKO65_17165	COG2076	Multidrug Resistance protein
AKO65_17170	COG2076	Multidrug Resistance protein
AKO65_17180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO65_17195	COG1695	Transcriptional regulator
AKO65_17200	COG1607	acyl-coa hydrolase
AKO65_17205	COG1834	amidinotransferase
AKO65_17210	COG4608	Belongs to the ABC transporter superfamily
AKO65_17215	COG0791	NLP P60 protein
AKO65_17220	COG4948	Mandelate Racemase Muconate Lactonizing
AKO65_17225	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO65_17230	COG4166	transmembrane transport
AKO65_17235	COG0444	Belongs to the ABC transporter superfamily
AKO65_17240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_17245	COG0601	transmembrane transport
AKO65_17250	COG2362	D-Aminopeptidase
AKO65_17255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO65_17260	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO65_17265	COG0346	lactoylglutathione lyase activity
AKO65_17270	COG0531	amino acid
AKO65_17280	COG2390	Transcriptional regulator
AKO65_17285	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_17290	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_17295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO65_17300	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_17305	COG0022	dehydrogenase e1 component
AKO65_17305	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO65_17310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO65_17315	COG1063	alcohol dehydrogenase
AKO65_17330	COG3775	system Galactitol-specific IIC component
AKO65_17345	COG4208	sulfate ABC transporter
AKO65_17355	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKO65_17360	COG0405	Gamma-glutamyltransferase
AKO65_17370	COG1392	Phosphate transport regulator
AKO65_17375	COG0306	phosphate transporter
AKO65_17390	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO65_17390	COG3409	Peptidoglycan-binding domain 1 protein
AKO65_17400	COG2856	Zn peptidase
AKO65_17405	COG4195	phage-related replication protein
AKO65_17425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_17430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_17435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_17440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO65_17450	COG1309	transcriptional regulator
AKO65_17460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO65_17495	COG2807	transmembrane transport
AKO65_17500	COG0583	DNA-binding transcription factor activity
AKO65_17520	COG0583	DNA-binding transcription factor activity
AKO65_17545	COG0457	Tetratricopeptide repeat
AKO65_17555	COG2364	Membrane
AKO65_17560	COG2153	protein acetylation
AKO65_17565	COG0457	Tetratricopeptide repeat
AKO65_17575	COG0583	DNA-binding transcription factor activity
AKO65_17585	COG2807	transmembrane transport
AKO65_17605	COG0825	malonyl-CoA metabolic process
AKO65_17610	COG0113	porphobilinogen synthase activity
AKO65_17745	COG0626	cystathionine gamma-synthase activity
AKO65_17750	COG0626	cystathionine gamma-synthase activity
AKO65_17755	COG2382	esterase
AKO65_17760	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO65_17765	COG2153	protein acetylation
AKO65_17775	COG0210	DNA helicase
AKO65_17825	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKO65_17830	COG0351	phosphomethylpyrimidine kinase
AKO65_17835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO65_17840	COG2022	thiamine diphosphate biosynthetic process
AKO65_17845	COG2104	thiamine diphosphate biosynthetic process
AKO65_17855	COG0352	thiamine-phosphate diphosphorylase activity
AKO65_17860	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO65_17865	COG0569	domain protein
AKO65_17865	COG0475	glutathione-regulated potassium exporter activity
AKO65_17870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKO65_17875	COG0564	pseudouridine synthase activity
AKO65_17880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO65_17885	COG2357	RelA SpoT domain protein
AKO65_17895	COG4116	CYTH
AKO65_17900	COG0741	lytic transglycosylase activity
AKO65_17905	COG2346	COG2346, Truncated hemoglobins
AKO65_17915	COG1164	Oligoendopeptidase f
AKO65_17925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO65_17930	COG4862	establishment of competence for transformation
AKO65_17935	COG0861	Integral membrane protein TerC family
AKO65_17940	COG1393	Belongs to the ArsC family
AKO65_17945	COG0456	acetyltransferase
AKO65_17955	COG4608	Belongs to the ABC transporter superfamily
AKO65_17960	COG0444	Belongs to the ABC transporter superfamily
AKO65_17965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_17970	COG0601	transmembrane transport
AKO65_17975	COG4166	transmembrane transport
AKO65_17980	COG0180	Tryptophanyl-tRNA synthetase
AKO65_17990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO65_17995	COG0601	transmembrane transport
AKO65_18005	COG4608	Belongs to the ABC transporter superfamily
AKO65_18010	COG0444	Belongs to the ABC transporter superfamily
AKO65_18015	COG5504	Zn-dependent protease
AKO65_18020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO65_18025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO65_18040	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO65_18050	COG2267	carboxylic ester hydrolase activity
AKO65_18060	COG2814	Major facilitator Superfamily
AKO65_18070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKO65_18075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO65_18080	COG0505	Belongs to the CarA family
AKO65_18085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO65_18090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKO65_18100	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKO65_18105	COG2271	Major facilitator Superfamily
AKO65_18110	COG0277	FAD linked oxidase domain protein
AKO65_18115	COG2151	metal-sulfur cluster biosynthetic enzyme
AKO65_18120	COG1073	alpha beta
AKO65_18125	COG0561	phosphatase activity
AKO65_18145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO65_18150	COG1307	EDD domain protein, DegV family
AKO65_18155	COG0840	transmembrane signaling receptor activity
AKO65_18165	COG2996	Protein conserved in bacteria
AKO65_18170	COG1666	GTP binding
AKO65_18175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKO65_18175	COG0646	methionine synthase
AKO65_18180	COG1410	methionine synthase
AKO65_18180	COG0646	methionine synthase
AKO65_18215	COG0076	glutamate decarboxylase activity
AKO65_18240	COG1917	Cupin 2, conserved barrel domain protein
AKO65_18240	COG2207	Transcriptional regulator
AKO65_18245	COG0534	Mate efflux family protein
AKO65_18250	COG1562	ergosterol biosynthetic process
AKO65_18265	COG0367	asparagine synthase
AKO65_18280	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKO65_18295	COG5337	Spore coat protein CotH
AKO65_18335	COG1403	HNH endonuclease
AKO65_18340	COG0419	ATPase involved in DNA repair
AKO65_18345	COG0420	3'-5' exonuclease activity
AKO65_18350	COG1074	ATP-dependent DNA helicase activity
AKO65_18355	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AKO65_18360	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AKO65_18365	COG2259	Doxx family
AKO65_18380	COG3180	Ammonia monooxygenase
AKO65_18385	COG0681	Belongs to the peptidase S26 family
AKO65_18390	COG0398	Pfam SNARE associated Golgi protein
AKO65_18405	COG1316	TRANSCRIPTIONal
AKO65_18410	COG4607	ABC-type enterochelin transport system periplasmic component
AKO65_18415	COG4604	ABC transporter, ATP-binding protein
AKO65_18420	COG4605	iron ion homeostasis
AKO65_18425	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO65_18430	COG2732	(Barnase) inhibitor
AKO65_18435	COG2814	Major facilitator Superfamily
AKO65_18440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO65_18455	COG4903	ComK protein
AKO65_18465	COG1028	Short-chain dehydrogenase reductase Sdr
AKO65_18470	COG0723	plastoquinol--plastocyanin reductase activity
AKO65_18470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKO65_18475	COG0840	transmembrane signaling receptor activity
AKO65_18480	COG0406	alpha-ribazole phosphatase activity
AKO65_18485	COG1404	Belongs to the peptidase S8 family
AKO65_18490	COG0501	Belongs to the peptidase M48B family
AKO65_18500	COG0318	PFAM AMP-dependent synthetase and ligase
AKO65_18505	COG0095	Lipoate-protein ligase
AKO65_18510	COG1234	tRNA 3'-trailer cleavage
AKO65_18515	COG1301	dicarboxylic acid transport
AKO65_18520	COG1363	Peptidase, m42
AKO65_18525	COG1511	domain protein
AKO65_18530	COG1309	transcriptional regulator
AKO65_18545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKO65_18550	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO65_18555	COG2329	Antibiotic biosynthesis monooxygenase
AKO65_18565	COG1473	amidohydrolase
AKO65_18575	COG4473	ABC transporter
AKO65_18580	COG1131	(ABC) transporter
AKO65_18585	COG0537	adenosine 5'-monophosphoramidase activity
AKO65_18590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKO65_18605	COG4980	gas vesicle protein
AKO65_18610	COG1846	Transcriptional regulator
AKO65_18630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO65_18640	COG3481	metal-dependent phosphohydrolase, HD sub domain
AKO65_18645	COG4717	serine-type aminopeptidase activity
AKO65_18650	COG0420	3'-5' exonuclease activity
AKO65_18660	COG1024	Enoyl-CoA hydratase
AKO65_18670	COG0490	domain, Protein
AKO65_18675	COG0475	glutathione-regulated potassium exporter activity
AKO65_18685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO65_18690	COG0561	phosphatase activity
AKO65_18695	COG3679	Belongs to the UPF0342 family
AKO65_18700	COG4399	Belongs to the UPF0754 family
AKO65_18705	COG0189	ligase activity
AKO65_18710	COG0189	ligase activity
AKO65_18720	COG2508	Transcriptional regulator
AKO65_18725	COG3842	ATPase activity
AKO65_18735	COG0702	epimerase
AKO65_18740	COG1132	(ABC) transporter
AKO65_18745	COG1132	(ABC) transporter
AKO65_18750	COG0589	response to stress
AKO65_18755	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO65_18760	COG0726	polysaccharide deacetylase
AKO65_18765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKO65_18770	COG0668	transmembrane transport
AKO65_18775	COG0584	glycerophosphoryl diester phosphodiesterase
AKO65_18780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKO65_18795	COG1253	flavin adenine dinucleotide binding
AKO65_18800	COG0789	Transcriptional regulator
AKO65_18805	COG1253	flavin adenine dinucleotide binding
AKO65_18810	COG0204	Acyl-transferase
AKO65_18815	COG1595	DNA-templated transcription, initiation
AKO65_18830	COG0531	amino acid
AKO65_18835	COG1388	LysM domain
AKO65_18835	COG0791	NLP P60 protein
AKO65_18840	COG1785	Belongs to the alkaline phosphatase family
AKO65_18845	COG2719	SpoVR family
AKO65_18850	COG1017	nitric oxide dioxygenase activity
AKO65_18850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKO65_18855	COG1959	2 iron, 2 sulfur cluster binding
AKO65_18860	COG0753	catalase activity
AKO65_18875	COG2197	response regulator
AKO65_18880	COG2203	Gaf domain
AKO65_18880	COG4585	Histidine kinase
AKO65_18885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO65_18890	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKO65_18895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKO65_18900	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AKO65_18905	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AKO65_18910	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO65_18915	COG3835	regulator
AKO65_18935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO65_18935	COG3153	acetyltransferase
AKO65_18940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKO65_18950	COG0564	pseudouridine synthase activity
AKO65_18955	COG3764	Sortase (surface protein transpeptidase)
AKO65_18960	COG4085	toxin activity
AKO65_18960	COG1525	nuclease
AKO65_18960	COG0737	Belongs to the 5'-nucleotidase family
AKO65_18965	COG5002	protein histidine kinase activity
AKO65_18970	COG5577	PFAM Coat F domain
AKO65_18995	COG3706	GGDEF domain
AKO65_19000	COG1278	Cold shock
AKO65_19010	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO65_19015	COG2814	Major facilitator Superfamily
AKO65_19020	COG1566	PFAM secretion protein HlyD family protein
AKO65_19025	COG2718	Belongs to the UPF0229 family
AKO65_19030	COG2766	serine protein kinase
AKO65_19035	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKO65_19045	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKO65_19050	COG3382	B3 4 domain protein
AKO65_19080	COG1131	(ABC) transporter
AKO65_19095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO65_19100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO65_19105	COG1116	anion transmembrane transporter activity
AKO65_19120	COG0681	Belongs to the peptidase S26 family
AKO65_19125	COG1368	sulfuric ester hydrolase activity