locus-tag	class	description
AKO66_00005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AKO66_00010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO66_00015	COG1396	sequence-specific DNA binding
AKO66_00020	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AKO66_00025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AKO66_00030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AKO66_00035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_00040	COG0512	Glutamine amidotransferase of anthranilate synthase
AKO66_00045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AKO66_00050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_00055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO66_00060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AKO66_00065	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AKO66_00070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AKO66_00080	COG0037	tRNA processing
AKO66_00085	COG0515	serine threonine protein kinase
AKO66_00090	COG2304	oxidoreductase activity
AKO66_00095	COG2208	phosphoserine phosphatase activity
AKO66_00110	COG1098	S1 RNA binding domain
AKO66_00115	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AKO66_00130	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AKO66_00135	COG3956	TIGRFAM MazG family protein
AKO66_00140	COG2244	polysaccharide biosynthetic process
AKO66_00145	COG2002	toxin-antitoxin pair type II binding
AKO66_00150	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AKO66_00160	COG0193	aminoacyl-tRNA hydrolase activity
AKO66_00165	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AKO66_00170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AKO66_00180	COG2088	sporulation resulting in formation of a cellular spore
AKO66_00185	COG0251	oxidation-reduction process
AKO66_00190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO66_00195	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AKO66_00205	COG4466	Protein conserved in bacteria
AKO66_00215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AKO66_00220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO66_00225	COG3584	3D domain protein
AKO66_00225	COG3583	domain protein
AKO66_00230	COG0084	hydrolase, TatD family'
AKO66_00235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_00235	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_00240	COG2002	toxin-antitoxin pair type II binding
AKO66_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AKO66_00250	COG2827	Endonuclease containing a URI domain
AKO66_00255	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AKO66_00260	COG4467	Involved in initiation control of chromosome replication
AKO66_00265	COG1774	PSP1 C-terminal conserved region
AKO66_00270	COG0470	DNA polymerase III
AKO66_00275	COG1728	Protein conserved in bacteria
AKO66_00280	COG3870	Protein conserved in bacteria
AKO66_00285	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AKO66_00290	COG1982	Orn Lys Arg decarboxylase major
AKO66_00295	COG3853	Toxic anion resistance protein (TelA)
AKO66_00300	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
AKO66_00345	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AKO66_00350	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AKO66_00355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AKO66_00360	COG0590	tRNA wobble adenosine to inosine editing
AKO66_00365	COG1335	isochorismatase
AKO66_00370	COG3858	chitin binding
AKO66_00370	COG1388	LysM domain
AKO66_00375	COG1428	Deoxynucleoside kinase
AKO66_00380	COG1428	Deoxynucleoside kinase
AKO66_00390	COG0840	transmembrane signaling receptor activity
AKO66_00395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AKO66_00400	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AKO66_00405	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AKO66_00410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_00415	COG1686	Belongs to the peptidase S11 family
AKO66_00420	COG0517	IMP dehydrogenase activity
AKO66_00420	COG0516	GMP reductase activity
AKO66_00455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO66_00460	COG0187	DNA topoisomerase II activity
AKO66_00470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AKO66_00475	COG2501	S4 domain
AKO66_00480	COG0592	DNA-directed DNA polymerase activity
AKO66_00485	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AKO66_00490	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AKO66_00495	COG0594	ribonuclease P activity
AKO66_00500	COG0706	membrane insertase activity
AKO66_00505	COG1847	R3H domain protein
AKO66_00510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AKO66_00515	COG0445	tRNA wobble uridine modification
AKO66_00520	COG0357	Ribosomal RNA small subunit methyltransferase G
AKO66_00525	COG1475	DNA binding
AKO66_00535	COG1192	Involved in chromosome partitioning
AKO66_00540	COG1475	DNA binding
AKO66_00550	COG3949	Membrane
AKO66_00565	COG4481	Protein conserved in bacteria
AKO66_00570	COG0012	GTP binding
AKO66_00575	COG0360	Binds together with S18 to 16S ribosomal RNA
AKO66_00580	COG0629	single-stranded DNA binding
AKO66_00585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AKO66_00590	COG1125	glycine betaine transport
AKO66_00590	COG0517	IMP dehydrogenase activity
AKO66_00595	COG1174	glycine betaine transport
AKO66_00600	COG0346	lactoylglutathione lyase activity
AKO66_00605	COG0400	carboxylic ester hydrolase activity
AKO66_00610	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO66_00615	COG0753	catalase activity
AKO66_00625	COG1595	DNA-templated transcription, initiation
AKO66_00635	COG1227	inorganic diphosphatase activity
AKO66_00640	COG4241	membrane
AKO66_00645	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
AKO66_00650	COG0359	binds to the 23S rRNA
AKO66_00655	COG2807	transmembrane transport
AKO66_00660	COG2819	hydrolase of the alpha beta superfamily
AKO66_00665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_00670	COG2207	Transcriptional regulator
AKO66_00670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_00675	COG2819	hydrolase of the alpha beta superfamily
AKO66_00695	COG0305	Participates in initiation and elongation during chromosome replication
AKO66_00700	COG0346	lactoylglutathione lyase activity
AKO66_00705	COG2124	cytochrome p450
AKO66_00710	COG1309	transcriptional regulator
AKO66_00715	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AKO66_00720	COG2311	Membrane
AKO66_00730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO66_00755	COG0745	RESPONSE REGULATOR receiver
AKO66_00760	COG5002	protein histidine kinase activity
AKO66_00765	COG4863	YycH protein
AKO66_00770	COG4853	Protein conserved in bacteria
AKO66_00775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AKO66_00780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_00785	COG0456	acetyltransferase
AKO66_00805	COG4720	Psort location CytoplasmicMembrane, score
AKO66_00815	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO66_00820	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AKO66_00850	COG2409	Drug exporters of the RND superfamily
AKO66_00860	COG5002	protein histidine kinase activity
AKO66_00860	COG3850	Histidine kinase
AKO66_00875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AKO66_00895	COG0583	DNA-binding transcription factor activity
AKO66_00900	COG0384	phenazine biosynthesis protein PhzF
AKO66_00915	COG2188	Transcriptional regulator
AKO66_00920	COG2190	(PTS) system
AKO66_00920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_00920	COG1263	PTS System
AKO66_00925	COG2723	6-phospho-beta-galactosidase activity
AKO66_00955	COG2814	Major facilitator Superfamily
AKO66_00960	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO66_00965	COG2814	Major facilitator Superfamily
AKO66_00975	COG1113	amino acid transport
AKO66_00990	COG0494	nUDIX hydrolase
AKO66_01015	COG2190	(PTS) system
AKO66_01015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_01015	COG1263	PTS System
AKO66_01020	COG2723	6-phospho-beta-galactosidase activity
AKO66_01025	COG3711	transcriptional antiterminator
AKO66_01030	COG0457	Tetratricopeptide repeat
AKO66_01040	COG1136	(ABC) transporter
AKO66_01050	COG2814	Major facilitator Superfamily
AKO66_01055	COG1309	transcriptional regulator
AKO66_01060	COG3835	regulator
AKO66_01065	COG2610	gluconate transmembrane transporter activity
AKO66_01070	COG1929	Belongs to the glycerate kinase type-1 family
AKO66_01075	COG2824	Alkylphosphonate utilization operon protein PhnA
AKO66_01080	COG1131	(ABC) transporter
AKO66_01085	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO66_01095	COG2851	Citrate transporter
AKO66_01100	COG1874	Beta-galactosidase
AKO66_01110	COG3833	ABC-type maltose transport systems, permease component
AKO66_01115	COG1175	transmembrane transport
AKO66_01120	COG2182	Extracellular solute-binding protein
AKO66_01125	COG1609	Transcriptional regulator
AKO66_01130	COG0583	DNA-binding transcription factor activity
AKO66_01170	COG1737	Transcriptional regulator
AKO66_01175	COG1070	Carbohydrate kinase
AKO66_01185	COG4335	DNA alkylation repair
AKO66_01190	COG1113	amino acid transport
AKO66_01195	COG0840	transmembrane signaling receptor activity
AKO66_01200	COG0673	inositol 2-dehydrogenase activity
AKO66_01205	COG0789	Transcriptional regulator
AKO66_01210	COG0561	phosphatase activity
AKO66_01220	COG2226	methyltransferase
AKO66_01225	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO66_01230	COG0477	Major facilitator Superfamily
AKO66_01235	COG2755	lipolytic protein G-D-S-L family
AKO66_01235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AKO66_01245	COG2390	Transcriptional regulator
AKO66_01250	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
AKO66_01255	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
AKO66_01260	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
AKO66_01265	COG1846	Transcriptional regulator
AKO66_01270	COG0778	Nitroreductase
AKO66_01275	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
AKO66_01280	COG3291	Pkd domain containing protein
AKO66_01280	COG4412	M6 family metalloprotease domain protein
AKO66_01310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO66_01315	COG4721	ABC-type cobalt transport system, permease component
AKO66_01320	COG1122	ATPase activity
AKO66_01325	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO66_01335	COG3878	Protein conserved in bacteria
AKO66_01340	COG3711	transcriptional antiterminator
AKO66_01345	COG1263	PTS System
AKO66_01345	COG2190	(PTS) system
AKO66_01345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_01350	COG2723	6-phospho-beta-galactosidase activity
AKO66_01375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO66_01380	COG2610	gluconate transmembrane transporter activity
AKO66_01390	COG2084	Dehydrogenase
AKO66_01395	COG1737	Transcriptional regulator
AKO66_01410	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO66_01415	COG4842	Belongs to the WXG100 family
AKO66_01440	COG1396	sequence-specific DNA binding
AKO66_01445	COG0252	asparaginase activity
AKO66_01450	COG1027	Aspartate ammonia-lyase
AKO66_01455	COG1757	Na H antiporter
AKO66_01480	COG3711	transcriptional antiterminator
AKO66_01480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_01485	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_01490	COG1312	Catalyzes the dehydration of D-mannonate
AKO66_01495	COG2723	6-phospho-beta-galactosidase activity
AKO66_01500	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_01505	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO66_01510	COG0726	polysaccharide deacetylase
AKO66_01520	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_01520	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_01525	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_01525	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_01530	COG2514	catechol 2,3-dioxygenase activity
AKO66_01535	COG1733	regulation of RNA biosynthetic process
AKO66_01540	COG5386	Cell surface protein
AKO66_01545	COG5386	Cell surface protein
AKO66_01570	COG4509	Sortase family
AKO66_01575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO66_01580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_01585	COG1120	ATPase activity
AKO66_01590	COG1271	oxidase subunit
AKO66_01595	COG1294	oxidase, subunit
AKO66_01600	COG4988	ABC transporter
AKO66_01605	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
AKO66_01610	COG3866	Pectate lyase
AKO66_01615	COG1595	DNA-templated transcription, initiation
AKO66_01630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO66_01645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_01645	COG3711	transcriptional antiterminator
AKO66_01650	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_01655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_01660	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO66_01665	COG1486	melibiose metabolic process
AKO66_01680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_01685	COG3420	alginic acid biosynthetic process
AKO66_01695	COG1129	ABC transporter
AKO66_01700	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO66_01705	COG2357	RelA SpoT domain protein
AKO66_01710	COG0457	Tetratricopeptide repeat
AKO66_01715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_01720	COG0765	amino acid transport
AKO66_01735	COG0346	lactoylglutathione lyase activity
AKO66_01740	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AKO66_01745	COG1346	cytolysis
AKO66_01750	COG1380	Effector of murein hydrolase LrgA
AKO66_01755	COG0583	DNA-binding transcription factor activity
AKO66_01760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AKO66_01765	COG0352	thiamine-phosphate diphosphorylase activity
AKO66_01780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO66_01785	COG3162	membrane
AKO66_01795	COG4106	trans-aconitate 2-methyltransferase activity
AKO66_01805	COG2246	polysaccharide biosynthetic process
AKO66_01820	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AKO66_01825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AKO66_01830	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
AKO66_01840	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO66_01845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO66_01850	COG1845	cytochrome c oxidase, subunit III
AKO66_01855	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO66_01865	COG0772	Belongs to the SEDS family
AKO66_01870	COG0778	Nitroreductase
AKO66_01875	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_01885	COG1404	Belongs to the peptidase S8 family
AKO66_01895	COG3711	transcriptional antiterminator
AKO66_01900	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_01900	COG1263	PTS System
AKO66_01905	COG1621	beta-fructofuranosidase activity
AKO66_01920	COG0351	phosphomethylpyrimidine kinase
AKO66_01930	COG1216	Glycosyl transferase, family 2
AKO66_01935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AKO66_01940	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_01950	COG2233	PERMEase
AKO66_01955	COG2363	Small membrane protein
AKO66_01975	COG0463	Glycosyl transferase, family 2
AKO66_01980	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_01985	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO66_01990	COG0456	acetyltransferase
AKO66_01995	COG2089	acid synthase
AKO66_02000	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
AKO66_02005	COG3980	spore coat polysaccharide biosynthesis protein
AKO66_02010	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO66_02015	COG1088	dTDP-glucose 4,6-dehydratase activity
AKO66_02020	COG1091	dTDP-4-dehydrorhamnose reductase activity
AKO66_02025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AKO66_02030	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_02035	COG0436	Aminotransferase
AKO66_02040	COG0151	Belongs to the GarS family
AKO66_02045	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_02050	COG1917	Cupin 2, conserved barrel domain protein
AKO66_02055	COG0077	Prephenate dehydratase
AKO66_02060	COG2814	Major facilitator Superfamily
AKO66_02065	COG1522	sequence-specific DNA binding
AKO66_02070	COG2814	Major facilitator Superfamily
AKO66_02080	COG0280	phosphate acetyltransferase
AKO66_02090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AKO66_02120	COG5444	nuclease activity
AKO66_02170	COG4844	belongs to the
AKO66_02175	COG1078	dGTPase activity
AKO66_02180	COG3465	dGTPase activity
AKO66_02190	COG1942	4-Oxalocrotonate Tautomerase
AKO66_02195	COG1994	Peptidase M50
AKO66_02205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_02210	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AKO66_02215	COG0010	Belongs to the arginase family
AKO66_02225	COG4506	Protein conserved in bacteria
AKO66_02230	COG0018	arginyl-trna synthetase
AKO66_02235	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO66_02240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_02245	COG1132	(ABC) transporter
AKO66_02250	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO66_02260	COG4294	response to UV
AKO66_02265	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_02270	COG0247	lactate metabolic process
AKO66_02270	COG2181	nitrate reductase activity
AKO66_02275	COG0183	Belongs to the thiolase family
AKO66_02280	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO66_02285	COG1960	acyl-CoA dehydrogenase activity
AKO66_02290	COG1960	acyl-CoA dehydrogenase activity
AKO66_02315	COG1131	(ABC) transporter
AKO66_02325	COG3343	RNA polymerase activity
AKO66_02330	COG0504	CTP synthase activity
AKO66_02335	COG4821	SIS domain
AKO66_02340	COG2204	response regulator
AKO66_02345	COG0191	fructose-bisphosphate aldolase activity
AKO66_02350	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AKO66_02355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO66_02360	COG1494	fructose-1,6-bisphosphatase
AKO66_02365	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AKO66_02370	COG0254	rRNA binding
AKO66_02375	COG1435	thymidine kinase activity
AKO66_02380	COG0281	malic enzyme
AKO66_02385	COG0679	Auxin Efflux Carrier
AKO66_02390	COG0789	Transcriptional regulator
AKO66_02395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AKO66_02400	COG2890	protein-(glutamine-N5) methyltransferase activity
AKO66_02415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AKO66_02420	COG0009	L-threonylcarbamoyladenylate synthase
AKO66_02425	COG1971	Probably functions as a manganese efflux pump
AKO66_02430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO66_02435	COG0698	ribose 5-phosphate isomerase
AKO66_02440	COG4475	Protein of unknown function (DUF436)
AKO66_02445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AKO66_02450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AKO66_02460	COG0356	it plays a direct role in the translocation of protons across the membrane
AKO66_02465	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO66_02470	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AKO66_02475	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AKO66_02480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AKO66_02485	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AKO66_02490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AKO66_02495	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AKO66_02505	COG4836	Membrane
AKO66_02515	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AKO66_02520	COG2385	sporulation resulting in formation of a cellular spore
AKO66_02525	COG2304	oxidoreductase activity
AKO66_02530	COG2304	oxidoreductase activity
AKO66_02545	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AKO66_02550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AKO66_02555	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO66_02560	COG0523	cobalamin synthesis protein
AKO66_02565	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO66_02575	COG1247	-acetyltransferase
AKO66_02580	COG0739	heme binding
AKO66_02585	COG0347	Belongs to the P(II) protein family
AKO66_02590	COG0004	ammonium transporteR
AKO66_02595	COG1126	abc transporter atp-binding protein
AKO66_02600	COG0765	amino acid transport
AKO66_02605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_02610	COG0477	Major facilitator Superfamily
AKO66_02615	COG0671	phosphoesterase, PA-phosphatase related
AKO66_02620	COG2814	Major facilitator Superfamily
AKO66_02625	COG1846	Transcriptional regulator
AKO66_02630	COG1609	Transcriptional regulator
AKO66_02635	COG1077	Cell shape determining protein MreB Mrl
AKO66_02640	COG4786	Flagellar basal body rod
AKO66_02645	COG4786	Flagellar basal body rod
AKO66_02650	COG0457	Tetratricopeptide repeat
AKO66_02655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AKO66_02660	COG1970	mechanosensitive ion channel activity
AKO66_02675	COG0561	phosphatase activity
AKO66_02680	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_02680	COG2202	Pas domain
AKO66_02685	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO66_02690	COG4715	Zinc finger, swim domain protein
AKO66_02695	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO66_02700	COG2059	Chromate
AKO66_02705	COG2059	Chromate
AKO66_02710	COG1522	sequence-specific DNA binding
AKO66_02715	COG3527	Alpha-acetolactate decarboxylase
AKO66_02720	COG0028	Belongs to the TPP enzyme family
AKO66_02725	COG0583	DNA-binding transcription factor activity
AKO66_02730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AKO66_02735	COG1879	ABC-type sugar transport system periplasmic component
AKO66_02740	COG1172	Belongs to the binding-protein-dependent transport system permease family
AKO66_02745	COG1129	ABC transporter
AKO66_02750	COG1869	D-ribose catabolic process
AKO66_02755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO66_02760	COG1609	Transcriptional regulator
AKO66_02775	COG0697	spore germination
AKO66_02780	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO66_02790	COG2843	Capsule synthesis protein
AKO66_02795	COG0791	NLP P60 protein
AKO66_02800	COG0561	phosphatase activity
AKO66_02805	COG1316	TRANSCRIPTIONal
AKO66_02810	COG2814	Major facilitator Superfamily
AKO66_02825	COG0814	amino acid
AKO66_02830	COG0697	spore germination
AKO66_02835	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_02840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
AKO66_02845	COG1609	Transcriptional regulator
AKO66_02850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AKO66_02855	COG0800	Aldolase
AKO66_02860	COG0454	-acetyltransferase
AKO66_02870	COG2972	Histidine kinase
AKO66_02875	COG2197	response regulator
AKO66_02880	COG1653	transport
AKO66_02885	COG1175	transmembrane transport
AKO66_02895	COG1482	cell wall glycoprotein biosynthetic process
AKO66_02900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_02905	COG4193	domain, Protein
AKO66_02910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_02915	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AKO66_02920	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AKO66_02930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_02935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AKO66_02945	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
AKO66_02950	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO66_02960	COG1216	Glycosyl transferase, family 2
AKO66_02965	COG1682	transport, permease protein
AKO66_02970	COG1134	teichoic acid transport
AKO66_02975	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO66_02980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AKO66_02985	COG1316	TRANSCRIPTIONal
AKO66_02995	COG2247	cell wall binding repeat
AKO66_02995	COG2385	sporulation resulting in formation of a cellular spore
AKO66_03000	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_03000	COG2247	cell wall binding repeat
AKO66_03005	COG2247	cell wall binding repeat
AKO66_03005	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_03020	COG2244	polysaccharide biosynthetic process
AKO66_03025	COG0438	transferase activity, transferring glycosyl groups
AKO66_03025	COG0297	glycogen (starch) synthase activity
AKO66_03030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AKO66_03035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO66_03040	COG3307	-O-antigen
AKO66_03045	COG3206	protein involved in exopolysaccharide biosynthesis
AKO66_03050	COG1215	transferase activity, transferring glycosyl groups
AKO66_03055	COG0438	transferase activity, transferring glycosyl groups
AKO66_03060	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO66_03065	COG1316	TRANSCRIPTIONal
AKO66_03070	COG1739	Uncharacterized protein family UPF0029
AKO66_03075	COG4585	Histidine kinase
AKO66_03080	COG2197	response regulator
AKO66_03085	COG1307	EDD domain protein, DegV family
AKO66_03090	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
AKO66_03100	COG1040	competence protein
AKO66_03115	COG3418	PFAM FlgN family protein
AKO66_03120	COG4786	Flagellar basal body rod
AKO66_03120	COG1256	bacterial-type flagellum assembly
AKO66_03125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_03135	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AKO66_03140	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AKO66_03145	COG1334	flagellar protein FlaG
AKO66_03150	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AKO66_03155	COG1516	flagellar protein fliS
AKO66_03170	COG0840	transmembrane signaling receptor activity
AKO66_03175	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AKO66_03180	COG0653	protein targeting
AKO66_03185	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AKO66_03200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_03205	COG2010	Cytochrome c
AKO66_03210	COG2884	Cell division ATP-binding protein ftsE
AKO66_03215	COG2177	Part of the ABC transporter FtsEX involved in
AKO66_03220	COG0791	NLP P60 protein
AKO66_03220	COG3883	PFAM NLP P60 protein
AKO66_03225	COG0730	response to heat
AKO66_03230	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_03230	COG0793	Belongs to the peptidase S41A family
AKO66_03240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_03245	COG1733	regulation of RNA biosynthetic process
AKO66_03250	COG0778	Nitroreductase
AKO66_03255	COG1113	amino acid transport
AKO66_03260	COG0463	Glycosyl transferase, family 2
AKO66_03265	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO66_03270	COG5002	protein histidine kinase activity
AKO66_03275	COG0745	RESPONSE REGULATOR receiver
AKO66_03285	COG2814	Major facilitator Superfamily
AKO66_03290	COG1309	transcriptional regulator
AKO66_03295	COG0574	Belongs to the PEP-utilizing enzyme family
AKO66_03295	COG3848	Pyruvate phosphate dikinase
AKO66_03300	COG4897	Protein conserved in bacteria
AKO66_03315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AKO66_03330	COG3595	metallopeptidase activity
AKO66_03335	COG1983	PspC domain protein
AKO66_03340	COG1950	PFAM Membrane protein of
AKO66_03345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AKO66_03355	COG0363	glucosamine-6-phosphate deaminase activity
AKO66_03360	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AKO66_03365	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AKO66_03370	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AKO66_03375	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AKO66_03380	COG0546	phosphoglycolate phosphatase activity
AKO66_03385	COG0110	maltose O-acetyltransferase activity
AKO66_03390	COG1959	2 iron, 2 sulfur cluster binding
AKO66_03395	COG2910	NAD(P)H-binding
AKO66_03405	COG4990	cell redox homeostasis
AKO66_03410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AKO66_03415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AKO66_03420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AKO66_03425	COG0131	Imidazoleglycerol-phosphate dehydratase
AKO66_03430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AKO66_03435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AKO66_03440	COG0107	imidazoleglycerol-phosphate synthase activity
AKO66_03445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AKO66_03445	COG0140	phosphoribosyl-ATP diphosphatase activity
AKO66_03450	COG0457	Tetratricopeptide repeat
AKO66_03455	COG3883	PFAM NLP P60 protein
AKO66_03455	COG0791	NLP P60 protein
AKO66_03460	COG0492	ferredoxin-NADP+ reductase activity
AKO66_03465	COG1051	belongs to the nudix hydrolase family
AKO66_03470	COG1660	Displays ATPase and GTPase activities
AKO66_03475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AKO66_03480	COG1481	regulation of sporulation
AKO66_03485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_03490	COG2162	N-hydroxyarylamine O-acetyltransferase activity
AKO66_03500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO66_03505	COG0288	reversible hydration of carbon dioxide
AKO66_03510	COG0659	secondary active sulfate transmembrane transporter activity
AKO66_03515	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO66_03520	COG1611	Belongs to the LOG family
AKO66_03525	COG0740	serine-type endopeptidase activity
AKO66_03615	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AKO66_03620	COG0582	viral genome integration into host DNA
AKO66_03720	COG3953	SLT domain
AKO66_03720	COG5412	phage tail tape measure protein
AKO66_03730	COG1388	LysM domain
AKO66_03730	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO66_03755	COG4824	toxin secretion phage lysis holin
AKO66_03760	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_03785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_03790	COG1819	glycosyl
AKO66_03795	COG0747	negative chemotaxis
AKO66_03800	COG0601	transmembrane transport
AKO66_03815	COG1124	(ABC) transporter
AKO66_03825	COG0726	polysaccharide deacetylase
AKO66_03830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_03835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_03840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_03850	COG1396	sequence-specific DNA binding
AKO66_03855	COG3944	biosynthesis protein
AKO66_03860	COG0489	protein tyrosine kinase activity
AKO66_03865	COG1086	Polysaccharide biosynthesis protein
AKO66_03870	COG0438	transferase activity, transferring glycosyl groups
AKO66_03875	COG1215	transferase activity, transferring glycosyl groups
AKO66_03880	COG0438	transferase activity, transferring glycosyl groups
AKO66_03890	COG1216	Glycosyl transferase, family 2
AKO66_03895	COG5039	Polysaccharide pyruvyl transferase
AKO66_03900	COG2244	polysaccharide biosynthetic process
AKO66_03905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AKO66_03910	COG0110	maltose O-acetyltransferase activity
AKO66_03915	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO66_03920	COG0747	negative chemotaxis
AKO66_03925	COG0601	transmembrane transport
AKO66_03930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_03935	COG0444	Belongs to the ABC transporter superfamily
AKO66_03940	COG4608	Belongs to the ABC transporter superfamily
AKO66_03945	COG0534	Mate efflux family protein
AKO66_03955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AKO66_03960	COG2186	Transcriptional regulator
AKO66_03965	COG3829	transcription factor binding
AKO66_03970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO66_03975	COG0833	amino acid
AKO66_03980	COG2390	Transcriptional regulator
AKO66_03985	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO66_03990	COG0126	phosphoglycerate kinase activity
AKO66_03995	COG0149	triose-phosphate isomerase activity
AKO66_04000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AKO66_04005	COG0148	phosphopyruvate hydratase activity
AKO66_04015	COG1131	(ABC) transporter
AKO66_04035	COG0456	acetyltransferase
AKO66_04045	COG2095	MarC family integral membrane protein
AKO66_04050	COG1510	regulation of RNA biosynthetic process
AKO66_04055	COG0517	IMP dehydrogenase activity
AKO66_04055	COG1125	glycine betaine transport
AKO66_04060	COG1174	glycine betaine transport
AKO66_04065	COG1732	Glycine betaine
AKO66_04070	COG1174	glycine betaine transport
AKO66_04075	COG1733	regulation of RNA biosynthetic process
AKO66_04080	COG1396	sequence-specific DNA binding
AKO66_04085	COG1396	sequence-specific DNA binding
AKO66_04090	COG1476	TRANSCRIPTIONal
AKO66_04095	COG2002	toxin-antitoxin pair type II binding
AKO66_04100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO66_04105	COG1647	Serine aminopeptidase, S33
AKO66_04110	COG0557	exoribonuclease II activity
AKO66_04115	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AKO66_04135	COG3706	GGDEF domain
AKO66_04135	COG0745	RESPONSE REGULATOR receiver
AKO66_04145	COG1937	Protein conserved in bacteria
AKO66_04150	COG2608	mercury ion transmembrane transporter activity
AKO66_04155	COG2217	Heavy metal translocating P-type atpase
AKO66_04165	COG1027	Aspartate ammonia-lyase
AKO66_04170	COG4191	Histidine kinase
AKO66_04175	COG0784	Response regulator, receiver
AKO66_04180	COG3226	Transcriptional regulator
AKO66_04190	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO66_04195	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO66_04200	COG1121	(ABC) transporter
AKO66_04205	COG2217	Heavy metal translocating P-type atpase
AKO66_04210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AKO66_04215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AKO66_04220	COG2860	membrane
AKO66_04225	COG0025	NhaP-type Na H and K H
AKO66_04230	COG1940	carbohydrate kinase activity
AKO66_04235	COG0656	L-ascorbic acid biosynthetic process
AKO66_04240	COG4149	molybdate abc transporter
AKO66_04245	COG0725	ABC transporter, periplasmic molybdate-binding protein
AKO66_04250	COG1368	sulfuric ester hydrolase activity
AKO66_04255	COG1988	membrane-bound metal-dependent
AKO66_04275	COG0531	amino acid
AKO66_04280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_04285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_04290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_04295	COG1120	ATPase activity
AKO66_04300	COG0745	RESPONSE REGULATOR receiver
AKO66_04305	COG2205	protein histidine kinase activity
AKO66_04310	COG1904	glucuronate isomerase
AKO66_04315	COG1609	Transcriptional regulator
AKO66_04320	COG0246	Mannitol dehydrogenase
AKO66_04325	COG2721	sulfolactate sulfo-lyase activity
AKO66_04335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_04340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_04345	COG1120	ATPase activity
AKO66_04350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AKO66_04355	COG1454	alcohol dehydrogenase
AKO66_04370	COG3604	Transcriptional regulator
AKO66_04380	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AKO66_04385	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_04390	COG2096	Adenosyltransferase
AKO66_04395	COG4758	membrane
AKO66_04400	COG1842	Phage shock protein A
AKO66_04410	COG4758	membrane
AKO66_04415	COG4585	Histidine kinase
AKO66_04420	COG2197	response regulator
AKO66_04435	COG0814	amino acid
AKO66_04440	COG0697	spore germination
AKO66_04445	COG0114	fumarate hydratase activity
AKO66_04450	COG1309	transcriptional regulator
AKO66_04455	COG2205	protein histidine kinase activity
AKO66_04455	COG2770	Histidine kinase
AKO66_04460	COG0745	RESPONSE REGULATOR receiver
AKO66_04465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_04470	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_04480	COG1120	ATPase activity
AKO66_04490	COG5577	PFAM Coat F domain
AKO66_04500	COG1024	Enoyl-CoA hydratase
AKO66_04500	COG1250	3-hydroxyacyl-CoA dehydrogenase
AKO66_04505	COG0183	Belongs to the thiolase family
AKO66_04510	COG1960	acyl-CoA dehydrogenase activity
AKO66_04515	COG1393	Belongs to the ArsC family
AKO66_04520	COG0509	glycine decarboxylation via glycine cleavage system
AKO66_04530	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
AKO66_04535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_04545	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AKO66_04550	COG2011	ABC-type metal ion transport system permease component
AKO66_04555	COG1464	Belongs to the NlpA lipoprotein family
AKO66_04560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO66_04565	COG0396	ATPase activity
AKO66_04570	COG0719	Fe-S assembly protein
AKO66_04575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AKO66_04580	COG0822	iron-sulfur transferase activity
AKO66_04585	COG0719	Fe-S assembly protein
AKO66_04610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO66_04625	COG2311	Membrane
AKO66_04630	COG0745	RESPONSE REGULATOR receiver
AKO66_04635	COG5002	protein histidine kinase activity
AKO66_04635	COG0642	Histidine kinase
AKO66_04660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_04665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_04670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_04685	COG2356	endonuclease I
AKO66_04690	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AKO66_04695	COG2814	Major facilitator Superfamily
AKO66_04700	COG2140	Oxalate decarboxylase
AKO66_04705	COG2508	Transcriptional regulator
AKO66_04710	COG1801	Protein of unknown function DUF72
AKO66_04715	COG0737	Belongs to the 5'-nucleotidase family
AKO66_04720	COG3377	Domain of unknown function (DUF1805)
AKO66_04740	COG0739	heme binding
AKO66_04745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AKO66_04755	COG4470	Protein conserved in bacteria
AKO66_04760	COG2445	Protein of unknown function DUF86
AKO66_04765	COG0647	UMP catabolic process
AKO66_04770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO66_04775	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO66_04780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO66_04785	COG0460	homoserine dehydrogenase
AKO66_04790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AKO66_04795	COG0083	homoserine kinase activity
AKO66_04800	COG4946	Tricorn protease homolog
AKO66_04800	COG1506	peptidase
AKO66_04800	COG0823	Involved in the tonB-independent uptake of proteins
AKO66_04805	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AKO66_04810	COG4837	Protein of unknown function (DUF1462)
AKO66_04820	COG1252	NADH dehydrogenase
AKO66_04825	COG4844	belongs to the
AKO66_04830	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AKO66_04835	COG0316	Belongs to the HesB IscA family
AKO66_04850	COG0492	ferredoxin-NADP+ reductase activity
AKO66_04855	COG1252	NADH dehydrogenase
AKO66_04865	COG3584	3D domain protein
AKO66_04870	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
AKO66_04875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AKO66_04880	COG2056	Na+-H+ antiporter family
AKO66_04885	COG1268	BioY protein
AKO66_04890	COG0686	Belongs to the AlaDH PNT family
AKO66_04895	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO66_04895	COG2508	Transcriptional regulator
AKO66_04900	COG4842	Belongs to the WXG100 family
AKO66_04905	COG5417	Belongs to the EsaB family
AKO66_04910	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO66_04915	COG0433	COG0433 Predicted ATPase
AKO66_04915	COG1674	ftsk spoiiie
AKO66_04920	COG1511	domain protein
AKO66_04930	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_04935	COG1418	mRNA catabolic process
AKO66_04950	COG0628	permease
AKO66_04970	COG5506	Protein of unknown function (DUF1694)
AKO66_04975	COG1335	isochorismatase
AKO66_04980	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AKO66_04985	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
AKO66_05000	COG0142	geranyltranstransferase activity
AKO66_05010	COG4585	Histidine kinase
AKO66_05015	COG2197	response regulator
AKO66_05020	COG2050	protein possibly involved in aromatic compounds catabolism
AKO66_05025	COG1320	monovalent cation:proton antiporter activity
AKO66_05030	COG2212	antiporter activity
AKO66_05035	COG1863	multisubunit Na H antiporter MnhE subunit
AKO66_05040	COG0651	ATP synthesis coupled electron transport
AKO66_05045	COG1006	Multisubunit Na H antiporter MnhC subunit
AKO66_05050	COG2111	Na H antiporter
AKO66_05055	COG2111	Na H antiporter
AKO66_05055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AKO66_05065	COG3493	citrate carrier protein
AKO66_05090	COG4565	transcriptional regulatory protein
AKO66_05095	COG3290	protein histidine kinase activity
AKO66_05105	COG3011	Protein conserved in bacteria
AKO66_05110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_05115	COG2814	Major facilitator Superfamily
AKO66_05120	COG5018	Exonuclease
AKO66_05130	COG2205	protein histidine kinase activity
AKO66_05135	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AKO66_05145	COG2267	carboxylic ester hydrolase activity
AKO66_05150	COG1522	sequence-specific DNA binding
AKO66_05155	COG0436	Aminotransferase
AKO66_05160	COG1098	S1 RNA binding domain
AKO66_05165	COG2155	Conserved Protein
AKO66_05170	COG1979	alcohol dehydrogenase
AKO66_05175	COG1979	alcohol dehydrogenase
AKO66_05180	COG0166	Belongs to the GPI family
AKO66_05195	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AKO66_05205	COG2738	Putative neutral zinc metallopeptidase
AKO66_05210	COG1253	flavin adenine dinucleotide binding
AKO66_05215	COG0432	Pfam Uncharacterised protein family UPF0047
AKO66_05220	COG2070	2-Nitropropane dioxygenase
AKO66_05235	COG0840	transmembrane signaling receptor activity
AKO66_05240	COG0840	transmembrane signaling receptor activity
AKO66_05245	COG0840	transmembrane signaling receptor activity
AKO66_05250	COG0840	transmembrane signaling receptor activity
AKO66_05255	COG0693	protein deglycase activity
AKO66_05260	COG0673	inositol 2-dehydrogenase activity
AKO66_05270	COG0628	permease
AKO66_05285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AKO66_05295	COG1396	sequence-specific DNA binding
AKO66_05310	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
AKO66_05320	COG1595	DNA-templated transcription, initiation
AKO66_05325	COG5484	DNA packaging
AKO66_05330	COG1783	phage Terminase large subunit
AKO66_05335	COG5518	Phage portal protein
AKO66_05340	COG0338	D12 class N6 adenine-specific DNA methyltransferase
AKO66_05345	COG4653	Phage capsid family
AKO66_05390	COG3953	SLT domain
AKO66_05390	COG5280	Phage tail tape measure protein TP901
AKO66_05390	COG5280	Phage tail tape measure protein TP901
AKO66_05390	COG3953	SLT domain
AKO66_05395	COG1652	LysM domain
AKO66_05400	COG4193	domain, Protein
AKO66_05410	COG3628	GPW Gp25 family protein
AKO66_05415	COG3299	homolog of phage Mu protein gp47
AKO66_05420	COG3778	Protein conserved in bacteria
AKO66_05475	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_05475	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO66_05490	COG1510	regulation of RNA biosynthetic process
AKO66_05500	COG1454	alcohol dehydrogenase
AKO66_05505	COG2318	DinB family
AKO66_05510	COG1585	Membrane protein implicated in regulation of membrane protease activity
AKO66_05515	COG2268	Band 7 protein
AKO66_05520	COG0772	Belongs to the SEDS family
AKO66_05525	COG0772	Belongs to the SEDS family
AKO66_05530	COG3339	Conserved Protein
AKO66_05535	COG1247	-acetyltransferase
AKO66_05540	COG3859	Proton-coupled thiamine transporter YuaJ
AKO66_05680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO66_05685	COG1575	Belongs to the MenA family. Type 1 subfamily
AKO66_05690	COG1169	isochorismate synthase
AKO66_05695	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AKO66_05700	COG0596	Alpha beta hydrolase
AKO66_05705	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AKO66_05710	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_05715	COG4948	Mandelate Racemase Muconate Lactonizing
AKO66_05725	COG1294	oxidase, subunit
AKO66_05730	COG1271	oxidase subunit
AKO66_05740	COG3443	Belongs to the bacterial solute-binding protein 9 family
AKO66_05740	COG0803	Belongs to the bacterial solute-binding protein 9 family
AKO66_05745	COG0288	reversible hydration of carbon dioxide
AKO66_05750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AKO66_05755	COG1854	S-ribosylhomocysteine lyase activity
AKO66_05770	COG0783	Belongs to the Dps family
AKO66_05780	COG4824	toxin secretion phage lysis holin
AKO66_05795	COG2310	stress, protein
AKO66_05800	COG0494	nUDIX hydrolase
AKO66_05805	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO66_05810	COG1116	anion transmembrane transporter activity
AKO66_05815	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO66_05835	COG1233	COG1233 Phytoene dehydrogenase and related
AKO66_05840	COG1506	peptidase
AKO66_05850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AKO66_05855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AKO66_05860	COG0367	asparagine synthase
AKO66_05865	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AKO66_05870	COG2267	carboxylic ester hydrolase activity
AKO66_05880	COG4326	sporulation control protein
AKO66_05885	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
AKO66_05890	COG1242	4 iron, 4 sulfur cluster binding
AKO66_05910	COG1725	Transcriptional regulator
AKO66_05915	COG1131	(ABC) transporter
AKO66_05925	COG1136	(ABC) transporter
AKO66_05930	COG0577	efflux transmembrane transporter activity
AKO66_05935	COG2433	Pfam Transposase IS66
AKO66_05940	COG2202	Pas domain
AKO66_05940	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_05950	COG0495	leucyl-tRNA aminoacylation
AKO66_05955	COG1073	alpha beta
AKO66_05960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO66_05965	COG0395	ABC-type sugar transport system, permease component
AKO66_05970	COG1653	transport
AKO66_05975	COG0656	L-ascorbic acid biosynthetic process
AKO66_05980	COG2814	Major facilitator Superfamily
AKO66_05985	COG1733	regulation of RNA biosynthetic process
AKO66_05990	COG2207	Transcriptional regulator
AKO66_05995	COG4209	transmembrane transport
AKO66_06000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
AKO66_06005	COG1653	transport
AKO66_06010	COG0673	inositol 2-dehydrogenase activity
AKO66_06015	COG5578	integral membrane protein
AKO66_06020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_06030	COG3196	Protein conserved in bacteria
AKO66_06035	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AKO66_06045	COG2081	HI0933 family
AKO66_06050	COG2244	polysaccharide biosynthetic process
AKO66_06055	COG1187	pseudouridine synthase activity
AKO66_06060	COG1349	DNA-binding transcription factor activity
AKO66_06065	COG2252	PERMEase
AKO66_06070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO66_06075	COG3340	Belongs to the peptidase S51 family
AKO66_06080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_06085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO66_06095	COG1597	lipid kinase activity
AKO66_06100	COG0510	thiamine kinase activity
AKO66_06110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AKO66_06115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_06120	COG0281	malic enzyme
AKO66_06125	COG5584	Small secreted protein
AKO66_06130	COG1363	Peptidase, m42
AKO66_06145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_06150	COG4848	Belongs to the UPF0354 family
AKO66_06155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_06160	COG1674	ftsk spoiiie
AKO66_06165	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AKO66_06170	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
AKO66_06175	COG4980	gas vesicle protein
AKO66_06180	COG3118	belongs to the thioredoxin family
AKO66_06185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
AKO66_06185	COG1605	Chorismate mutase
AKO66_06190	COG1609	Transcriptional regulator
AKO66_06195	COG0123	including yeast histone deacetylase and acetoin utilization protein
AKO66_06200	COG0517	IMP dehydrogenase activity
AKO66_06205	COG0454	-acetyltransferase
AKO66_06210	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO66_06215	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AKO66_06220	COG2329	Antibiotic biosynthesis monooxygenase
AKO66_06225	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AKO66_06235	COG1335	isochorismatase
AKO66_06245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AKO66_06250	COG1956	GAF domain-containing protein
AKO66_06255	COG1309	transcriptional regulator
AKO66_06260	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO66_06265	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
AKO66_06270	COG1114	Component of the transport system for branched-chain amino acids
AKO66_06275	COG1114	Component of the transport system for branched-chain amino acids
AKO66_06280	COG1104	cysteine desulfurase activity
AKO66_06285	COG0301	tRNA thio-modification
AKO66_06295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AKO66_06300	COG1279	arginine transmembrane transporter activity
AKO66_06315	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO66_06320	COG0402	S-adenosylhomocysteine deaminase activity
AKO66_06325	COG0577	efflux transmembrane transporter activity
AKO66_06330	COG1136	(ABC) transporter
AKO66_06335	COG1695	Transcriptional regulator
AKO66_06340	COG0772	Belongs to the SEDS family
AKO66_06345	COG2205	protein histidine kinase activity
AKO66_06350	COG0745	RESPONSE REGULATOR receiver
AKO66_06355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AKO66_06360	COG2197	response regulator
AKO66_06365	COG4585	Histidine kinase
AKO66_06370	COG3239	Fatty acid desaturase
AKO66_06380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO66_06385	COG0616	signal peptide processing
AKO66_06390	COG1714	RDD family
AKO66_06400	COG3874	Sporulation protein YtfJ
AKO66_06405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AKO66_06410	COG0827	DNA restriction-modification system
AKO66_06415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AKO66_06420	COG0521	Mo-molybdopterin cofactor biosynthetic process
AKO66_06425	COG0137	argininosuccinate synthase activity
AKO66_06430	COG0165	Argininosuccinate lyase
AKO66_06440	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_06445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO66_06450	COG4109	DRTGG domain
AKO66_06460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AKO66_06480	COG0587	DNA-directed DNA polymerase activity
AKO66_06485	COG0281	malic enzyme
AKO66_06490	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AKO66_06495	COG0825	malonyl-CoA metabolic process
AKO66_06500	COG0205	6-phosphofructokinase activity
AKO66_06510	COG3030	protein affecting phage T7 exclusion by the F plasmid
AKO66_06515	COG0628	permease
AKO66_06520	COG2707	UPF0756 membrane protein
AKO66_06525	COG0372	Belongs to the citrate synthase family
AKO66_06530	COG0538	isocitrate dehydrogenase activity
AKO66_06535	COG0039	L-malate dehydrogenase activity
AKO66_06540	COG0745	RESPONSE REGULATOR receiver
AKO66_06545	COG5002	protein histidine kinase activity
AKO66_06550	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO66_06550	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO66_06555	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AKO66_06560	COG1971	Probably functions as a manganese efflux pump
AKO66_06565	COG0237	dephospho-CoA kinase activity
AKO66_06570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AKO66_06575	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AKO66_06585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AKO66_06590	COG3611	Membrane attachment protein
AKO66_06595	COG1484	DNA-dependent DNA replication
AKO66_06600	COG0398	Pfam SNARE associated Golgi protein
AKO66_06610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO66_06630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AKO66_06635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AKO66_06640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AKO66_06645	COG3326	Membrane
AKO66_06655	COG1363	Peptidase, m42
AKO66_06660	COG1966	Carbon starvation protein
AKO66_06670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO66_06675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AKO66_06680	COG0072	phenylalanine-tRNA ligase activity
AKO66_06680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_06685	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO66_06690	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
AKO66_06695	COG1286	toxin biosynthetic process
AKO66_06700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO66_06700	COG1796	DNA polymerase
AKO66_06705	COG1193	negative regulation of DNA recombination
AKO66_06710	COG3766	membrane
AKO66_06720	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_06725	COG1309	transcriptional regulator
AKO66_06730	COG1024	Enoyl-CoA hydratase
AKO66_06735	COG2086	electron transfer activity
AKO66_06740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AKO66_06745	COG3534	alpha-L-arabinofuranosidase
AKO66_06750	COG3118	belongs to the thioredoxin family
AKO66_06755	COG0322	excinuclease ABC activity
AKO66_06760	COG0527	aspartate kinase activity
AKO66_06765	COG1719	4-vinyl reductase, 4VR
AKO66_06770	COG2009	succinate dehydrogenase
AKO66_06775	COG1053	succinate dehydrogenase
AKO66_06780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AKO66_06785	COG0824	Thioesterase
AKO66_06790	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AKO66_06790	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AKO66_06795	COG2828	Protein conserved in bacteria
AKO66_06800	COG0583	DNA-binding transcription factor activity
AKO66_06805	COG2851	Citrate transporter
AKO66_06810	COG2197	response regulator
AKO66_06815	COG1846	Transcriptional regulator
AKO66_06820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AKO66_06825	COG5401	PFAM Sporulation and spore germination
AKO66_06830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AKO66_06835	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AKO66_06840	COG0622	Phosphoesterase
AKO66_06880	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_06885	COG1696	Membrane protein involved in D-alanine export
AKO66_06890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO66_06895	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
AKO66_06900	COG3339	Conserved Protein
AKO66_06905	COG2706	6-phosphogluconolactonase activity
AKO66_06910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_06915	COG0028	Belongs to the TPP enzyme family
AKO66_06920	COG0440	acetolactate synthase activity
AKO66_06925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AKO66_06930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO66_06935	COG0473	3-isopropylmalate dehydrogenase activity
AKO66_06940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AKO66_06945	COG0066	3-isopropylmalate dehydratase activity
AKO66_06950	COG1477	protein flavinylation
AKO66_06950	COG0457	Tetratricopeptide repeat
AKO66_06955	COG0544	peptidyl-prolyl cis-trans isomerase activity
AKO66_06960	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AKO66_06965	COG0470	DNA polymerase III
AKO66_06965	COG1067	ATP-dependent peptidase activity
AKO66_06970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AKO66_06975	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AKO66_06995	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AKO66_07000	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO66_07005	COG0181	hydroxymethylbilane synthase activity
AKO66_07010	COG1587	Uroporphyrinogen-III synthase
AKO66_07015	COG0113	porphobilinogen synthase activity
AKO66_07020	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO66_07025	COG1388	LysM domain
AKO66_07030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO66_07040	COG0525	valine-tRNA ligase activity
AKO66_07045	COG0285	dihydrofolate synthase activity
AKO66_07050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AKO66_07060	COG0424	maF-like protein
AKO66_07065	COG2003	Belongs to the UPF0758 family
AKO66_07070	COG1077	Cell shape determining protein MreB Mrl
AKO66_07075	COG1792	Involved in formation and maintenance of cell shape
AKO66_07080	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
AKO66_07085	COG0850	regulation of cytokinetic process
AKO66_07090	COG2894	cell division
AKO66_07095	COG0739	heme binding
AKO66_07100	COG1994	Peptidase M50
AKO66_07105	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AKO66_07110	COG2868	ribosomal protein
AKO66_07115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AKO66_07120	COG3290	protein histidine kinase activity
AKO66_07125	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AKO66_07130	COG4492	Belongs to the UPF0735 family
AKO66_07135	COG0077	Prephenate dehydratase
AKO66_07140	COG1827	regulation of RNA biosynthetic process
AKO66_07145	COG1104	cysteine desulfurase activity
AKO66_07150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
AKO66_07155	COG0157	Belongs to the NadC ModD family
AKO66_07160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AKO66_07165	COG1388	LysM domain
AKO66_07180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AKO66_07190	COG2112	serine threonine protein kinase
AKO66_07200	COG0632	four-way junction helicase activity
AKO66_07205	COG2255	four-way junction helicase activity
AKO66_07215	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AKO66_07220	COG0343	queuine tRNA-ribosyltransferase activity
AKO66_07225	COG1862	Preprotein translocase
AKO66_07235	COG2323	membrane
AKO66_07240	COG2244	polysaccharide biosynthetic process
AKO66_07250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO66_07250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AKO66_07255	COG0490	domain, Protein
AKO66_07260	COG5416	Lipopolysaccharide assembly protein A domain
AKO66_07265	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AKO66_07265	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AKO66_07270	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO66_07275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AKO66_07280	COG1490	D-aminoacyl-tRNA deacylase activity
AKO66_07285	COG3103	Sh3 type 3 domain protein
AKO66_07285	COG4991	sh3 domain protein
AKO66_07285	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_07290	COG0124	histidyl-tRNA synthetase
AKO66_07300	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AKO66_07305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AKO66_07310	COG1959	2 iron, 2 sulfur cluster binding
AKO66_07315	COG1104	cysteine desulfurase activity
AKO66_07320	COG0482	sulfurtransferase activity
AKO66_07325	COG0457	Tetratricopeptide repeat
AKO66_07330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AKO66_07335	COG3881	PFAM PRC-barrel domain
AKO66_07345	COG0765	amino acid transport
AKO66_07350	COG0765	amino acid transport
AKO66_07355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_07360	COG1126	abc transporter atp-binding protein
AKO66_07365	COG0628	permease
AKO66_07370	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AKO66_07375	COG4472	Bacterial protein of unknown function (DUF965)
AKO66_07380	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AKO66_07385	COG3906	Belongs to the UPF0473 family
AKO66_07395	COG1268	BioY protein
AKO66_07400	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_07405	COG0183	Belongs to the thiolase family
AKO66_07410	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO66_07430	COG0572	uridine kinase
AKO66_07435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AKO66_07440	COG0768	penicillin binding
AKO66_07455	COG2226	methyltransferase
AKO66_07460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AKO66_07465	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_07470	COG0626	cystathionine gamma-synthase activity
AKO66_07480	COG2226	methyltransferase
AKO66_07485	COG1063	alcohol dehydrogenase
AKO66_07490	COG0583	DNA-binding transcription factor activity
AKO66_07495	COG1115	amino acid carrier protein
AKO66_07505	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_07515	COG1063	alcohol dehydrogenase
AKO66_07525	COG0765	amino acid transport
AKO66_07530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_07535	COG1126	abc transporter atp-binding protein
AKO66_07540	COG1960	acyl-CoA dehydrogenase activity
AKO66_07545	COG2602	Beta-lactamase
AKO66_07575	COG1733	regulation of RNA biosynthetic process
AKO66_07580	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
AKO66_07585	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AKO66_07595	COG1846	Transcriptional regulator
AKO66_07605	COG1609	Transcriptional regulator
AKO66_07620	COG2160	L-arabinose isomerase activity
AKO66_07645	COG1122	ATPase activity
AKO66_07680	COG0726	polysaccharide deacetylase
AKO66_07710	COG0457	Tetratricopeptide repeat
AKO66_07720	COG2755	lipolytic protein G-D-S-L family
AKO66_07730	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
AKO66_07735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO66_07740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AKO66_07745	COG1534	Rna-binding protein
AKO66_07750	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AKO66_07755	COG1713	HD superfamily hydrolase involved in NAD metabolism
AKO66_07760	COG0799	negative regulation of ribosome biogenesis
AKO66_07765	COG2226	methyltransferase
AKO66_07770	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_07775	COG1555	photosystem II stabilization
AKO66_07775	COG1596	polysaccharide export
AKO66_07780	COG2131	deaminase
AKO66_07785	COG2333	competence protein COMEC
AKO66_07785	COG0658	competence protein
AKO66_07790	COG1466	dna polymerase III delta subunit
AKO66_07795	COG0268	Binds directly to 16S ribosomal RNA
AKO66_07800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AKO66_07805	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_07815	COG0481	GTPase activity
AKO66_07820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO66_07825	COG1420	regulation of RNA biosynthetic process
AKO66_07830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AKO66_07835	COG0443	Heat shock 70 kDa protein
AKO66_07840	COG0484	heat shock protein binding
AKO66_07845	COG2264	protein methyltransferase activity
AKO66_07850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AKO66_07855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO66_07860	COG1283	sodium-dependent phosphate transmembrane transporter activity
AKO66_07865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AKO66_07870	COG1610	YqeY-like protein
AKO66_07875	COG1030	water channel activity
AKO66_07880	COG4864	UPF0365 protein
AKO66_07895	COG0561	phosphatase activity
AKO66_07900	COG1702	phosphate starvation-inducible protein PhoH
AKO66_07905	COG1480	7TM receptor with intracellular HD hydrolase
AKO66_07910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AKO66_07915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AKO66_07920	COG0295	cytidine deaminase activity
AKO66_07925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AKO66_07930	COG1381	Involved in DNA repair and RecF pathway recombination
AKO66_07935	COG0752	glycyl-tRNA synthetase alpha subunit
AKO66_07940	COG0751	glycine-tRNA ligase activity
AKO66_07945	COG0517	IMP dehydrogenase activity
AKO66_07950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AKO66_07955	COG1671	Belongs to the UPF0178 family
AKO66_07960	COG0358	DNA primase activity
AKO66_07965	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AKO66_07970	COG2010	Cytochrome c
AKO66_07975	COG2384	SAM-dependent methyltransferase
AKO66_07980	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AKO66_07985	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AKO66_07995	COG0513	Belongs to the DEAD box helicase family
AKO66_08010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_08015	COG1121	(ABC) transporter
AKO66_08020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AKO66_08025	COG0735	belongs to the Fur family
AKO66_08030	COG1940	carbohydrate kinase activity
AKO66_08035	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
AKO66_08040	COG4709	membrane
AKO66_08045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AKO66_08050	COG1388	LysM domain
AKO66_08055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_08060	COG5521	maltodextrose utilization protein MalA
AKO66_08065	COG2839	Protein conserved in bacteria
AKO66_08070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO66_08075	COG0477	Major facilitator Superfamily
AKO66_08085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AKO66_08090	COG0573	inorganic phosphate transmembrane transporter activity
AKO66_08095	COG0581	inorganic phosphate transmembrane transporter activity
AKO66_08100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO66_08105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AKO66_08110	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AKO66_08125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AKO66_08130	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AKO66_08140	COG0457	Tetratricopeptide repeat
AKO66_08140	COG0705	Rhomboid family
AKO66_08145	COG4483	Protein conserved in bacteria
AKO66_08150	COG1940	carbohydrate kinase activity
AKO66_08155	COG1368	sulfuric ester hydrolase activity
AKO66_08160	COG2866	Carboxypeptidase
AKO66_08165	COG2814	Major facilitator Superfamily
AKO66_08170	COG0011	TIGRFAM Protein of
AKO66_08175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_08185	COG1393	Belongs to the ArsC family
AKO66_08195	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_08200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AKO66_08205	COG1459	type II secretion system
AKO66_08210	COG4537	Required for transformation and DNA binding
AKO66_08215	COG4970	Tfp pilus assembly protein FimT
AKO66_08250	COG0681	Belongs to the peptidase S26 family
AKO66_08270	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AKO66_08275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AKO66_08280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO66_08285	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AKO66_08290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_08295	COG0095	Lipoate-protein ligase
AKO66_08300	COG1321	iron dependent repressor
AKO66_08305	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO66_08315	COG3872	metal-dependent enzyme
AKO66_08325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AKO66_08330	COG0006	proline dipeptidase activity
AKO66_08335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AKO66_08345	COG3854	ATPases associated with a variety of cellular activities
AKO66_08385	COG0511	ligase activity, forming carbon-carbon bonds
AKO66_08390	COG0439	Biotin carboxylase
AKO66_08395	COG1302	Protein conserved in bacteria
AKO66_08400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO66_08405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AKO66_08410	COG1570	exodeoxyribonuclease VII activity
AKO66_08415	COG1722	exodeoxyribonuclease VII activity
AKO66_08420	COG0142	geranyltranstransferase activity
AKO66_08425	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AKO66_08430	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
AKO66_08435	COG1438	arginine binding
AKO66_08440	COG0497	DNA recombination
AKO66_08445	COG0750	zinc metalloprotease
AKO66_08450	COG0745	RESPONSE REGULATOR receiver
AKO66_08455	COG0457	Tetratricopeptide repeat
AKO66_08460	COG0584	glycerophosphoryl diester phosphodiesterase
AKO66_08470	COG3290	protein histidine kinase activity
AKO66_08470	COG3829	transcription factor binding
AKO66_08475	COG0280	phosphate acetyltransferase
AKO66_08485	COG3426	butyrate kinase activity
AKO66_08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO66_08495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO66_08500	COG0022	dehydrogenase e1 component
AKO66_08505	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_08515	COG1597	lipid kinase activity
AKO66_08525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_08530	COG0765	amino acid transport
AKO66_08535	COG1126	abc transporter atp-binding protein
AKO66_08540	COG4129	membrane
AKO66_08545	COG1376	ErfK ybiS ycfS ynhG family protein
AKO66_08550	COG0346	lactoylglutathione lyase activity
AKO66_08555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO66_08560	COG2195	Cleaves the N-terminal amino acid of tripeptides
AKO66_08565	COG0835	chemotaxis
AKO66_08570	COG0706	membrane insertase activity
AKO66_08580	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO66_08585	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AKO66_08595	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_08605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_08610	COG1447	Phosphotransferase system cellobiose-specific component IIA
AKO66_08615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
AKO66_08620	COG2723	6-phospho-beta-galactosidase activity
AKO66_08625	COG2188	Transcriptional regulator
AKO66_08630	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AKO66_08640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_08645	COG0596	Alpha beta hydrolase
AKO66_08650	COG1902	pentaerythritol trinitrate reductase activity
AKO66_08655	COG4187	Peptidase family M20/M25/M40
AKO66_08665	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_08670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_08675	COG0300	oxidoreductase activity
AKO66_08685	COG0446	pyridine nucleotide-disulphide oxidoreductase
AKO66_08690	COG1072	(Pantothenic acid kinase))
AKO66_08695	COG2211	Major facilitator Superfamily
AKO66_08705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AKO66_08715	COG0456	acetyltransferase
AKO66_08720	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO66_08720	COG0456	acetyltransferase
AKO66_08725	COG4305	rare lipoprotein A
AKO66_08730	COG4918	Iron-sulphur cluster biosynthesis
AKO66_08740	COG0457	Tetratricopeptide repeat
AKO66_08745	COG1073	alpha beta
AKO66_08760	COG0667	Aldo Keto reductase
AKO66_08765	COG0494	nUDIX hydrolase
AKO66_08770	COG1379	DNA repair
AKO66_08775	COG2153	protein acetylation
AKO66_08785	COG1404	Belongs to the peptidase S8 family
AKO66_08790	COG1300	Membrane
AKO66_08795	COG0735	belongs to the Fur family
AKO66_08805	COG4974	Belongs to the 'phage' integrase family
AKO66_08810	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
AKO66_08815	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AKO66_08820	COG1686	Belongs to the peptidase S11 family
AKO66_08830	COG2172	sigma factor antagonist activity
AKO66_08835	COG1191	sigma factor activity
AKO66_08855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO66_08870	COG0697	spore germination
AKO66_08875	COG0019	diaminopimelate decarboxylase activity
AKO66_08880	COG4086	secreted protein
AKO66_08885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AKO66_08890	COG2814	Major facilitator Superfamily
AKO66_08910	COG0307	riboflavin synthase, alpha
AKO66_08920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AKO66_08925	COG0456	acetyltransferase
AKO66_08930	COG1547	Domain of unknown function (DUF309)
AKO66_08935	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AKO66_08940	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AKO66_08950	COG1686	Belongs to the peptidase S11 family
AKO66_08955	COG2715	membrane protein required for spore maturation
AKO66_08960	COG0700	Nucleoside recognition
AKO66_08965	COG1187	pseudouridine synthase activity
AKO66_08970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_08975	COG1333	cytochrome c biogenesis protein
AKO66_08980	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AKO66_08985	COG0745	RESPONSE REGULATOR receiver
AKO66_08990	COG5002	protein histidine kinase activity
AKO66_08995	COG1595	DNA-templated transcription, initiation
AKO66_09010	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AKO66_09015	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
AKO66_09020	COG1141	Ferredoxin
AKO66_09025	COG4955	Helix-turn-helix domain
AKO66_09030	COG0514	ATP-dependent DNA helicase (RecQ)
AKO66_09035	COG1266	CAAX protease self-immunity
AKO66_09040	COG1388	LysM domain
AKO66_09050	COG1408	metallophosphoesterase
AKO66_09055	COG4862	establishment of competence for transformation
AKO66_09060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AKO66_09065	COG0492	ferredoxin-NADP+ reductase activity
AKO66_09070	COG2339	peptidase activity
AKO66_09075	COG3773	Cell wall hydrolase
AKO66_09075	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_09080	COG2959	enzyme of heme biosynthesis
AKO66_09085	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AKO66_09095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AKO66_09100	COG0539	negative regulation of cytoplasmic translation
AKO66_09105	COG1304	FMN binding
AKO66_09125	COG1160	GTP binding
AKO66_09130	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AKO66_09145	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO66_09150	COG0776	regulation of translation
AKO66_09155	COG0302	gtp cyclohydrolase
AKO66_09165	COG0142	geranyltranstransferase activity
AKO66_09170	COG2226	methyltransferase
AKO66_09175	COG0142	geranyltranstransferase activity
AKO66_09180	COG0105	UTP biosynthetic process
AKO66_09185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AKO66_09190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AKO66_09195	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AKO66_09200	COG4401	Chorismate mutase type I
AKO66_09210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AKO66_09215	COG0134	indole-3-glycerol-phosphate synthase activity
AKO66_09220	COG0135	phosphoribosylanthranilate isomerase activity
AKO66_09225	COG0133	tryptophan synthase activity
AKO66_09230	COG0159	tryptophan synthase activity
AKO66_09235	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AKO66_09240	COG0287	Prephenate dehydrogenase
AKO66_09245	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AKO66_09250	COG0457	Tetratricopeptide repeat
AKO66_09255	COG5582	Belongs to the UPF0302 family
AKO66_09265	COG0723	plastoquinol--plastocyanin reductase activity
AKO66_09270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO66_09275	COG2010	Cytochrome c
AKO66_09275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AKO66_09280	COG4347	Protein of unknown function (DUF1405)
AKO66_09290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_09295	COG1694	Mazg nucleotide pyrophosphohydrolase
AKO66_09300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AKO66_09305	COG1803	Methylglyoxal synthase
AKO66_09310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO66_09315	COG0438	transferase activity, transferring glycosyl groups
AKO66_09320	COG0617	tRNA 3'-terminal CCA addition
AKO66_09330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AKO66_09335	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AKO66_09340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AKO66_09345	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AKO66_09345	COG1199	ATP-dependent helicase activity
AKO66_09350	COG5353	protein conserved in bacteria
AKO66_09355	COG0017	Asparaginyl-tRNA synthetase
AKO66_09360	COG3935	DnaD domain protein
AKO66_09365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AKO66_09375	COG4499	WXG100 protein secretion system (Wss), protein YukC
AKO66_09375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_09380	COG3331	DNA recombination
AKO66_09410	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO66_09415	COG2190	(PTS) system
AKO66_09420	COG1902	pentaerythritol trinitrate reductase activity
AKO66_09530	COG1802	Transcriptional regulator
AKO66_09530	COG4626	Terminase
AKO66_09610	COG1705	Flagellar rod assembly protein muramidase FlgJ
AKO66_09610	COG3942	CHAP domain
AKO66_09635	COG4824	toxin secretion phage lysis holin
AKO66_09640	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_09660	COG0457	Tetratricopeptide repeat
AKO66_09675	COG1111	helicase
AKO66_09675	COG1205	dead DEAH box helicase
AKO66_09680	COG3359	exonuclease
AKO66_09685	COG4474	Belongs to the UPF0398 family
AKO66_09690	COG3599	regulation of cell shape
AKO66_09695	COG0116	Belongs to the methyltransferase superfamily
AKO66_09705	COG1199	ATP-dependent helicase activity
AKO66_09710	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
AKO66_09715	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AKO66_09720	COG2233	PERMEase
AKO66_09725	COG0726	polysaccharide deacetylase
AKO66_09730	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
AKO66_09730	COG0456	acetyltransferase
AKO66_09735	COG3424	synthase
AKO66_09740	COG1755	Isoprenylcysteine carboxyl methyltransferase
AKO66_09745	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
AKO66_09755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AKO66_09765	COG0328	RNA-DNA hybrid ribonuclease activity
AKO66_09770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
AKO66_09775	COG0328	RNA-DNA hybrid ribonuclease activity
AKO66_09790	COG1278	Cold shock
AKO66_09800	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO66_09805	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
AKO66_09810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
AKO66_09815	COG0386	Belongs to the glutathione peroxidase family
AKO66_09820	COG1418	mRNA catabolic process
AKO66_09825	COG1413	lyase activity
AKO66_09830	COG0129	dihydroxy-acid dehydratase activity
AKO66_09840	COG2136	Putative SAM-dependent methyltransferase
AKO66_09840	COG2521	methyltransferase
AKO66_09850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AKO66_09855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AKO66_09860	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO66_09865	COG0204	Acyl-transferase
AKO66_09870	COG1272	protein, Hemolysin III
AKO66_09875	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
AKO66_09880	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AKO66_09895	COG1999	signal sequence binding
AKO66_09900	COG2755	lipolytic protein G-D-S-L family
AKO66_09905	COG4698	Protein conserved in bacteria
AKO66_09925	COG1846	Transcriptional regulator
AKO66_09930	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO66_09935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AKO66_09940	COG1086	Polysaccharide biosynthesis protein
AKO66_09950	COG4641	Protein conserved in bacteria
AKO66_09965	COG0463	Glycosyl transferase, family 2
AKO66_09970	COG3829	transcription factor binding
AKO66_09975	COG1509	lysine 2,3-aminomutase activity
AKO66_09985	COG4479	Belongs to the UPF0346 family
AKO66_09995	COG0671	phosphoesterase, PA-phosphatase related
AKO66_10005	COG0813	purine-nucleoside phosphorylase activity
AKO66_10010	COG1876	peptidase activity
AKO66_10020	COG2226	methyltransferase
AKO66_10025	COG0793	Belongs to the peptidase S41A family
AKO66_10025	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_10030	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO66_10040	COG0778	Nitroreductase
AKO66_10045	COG1733	regulation of RNA biosynthetic process
AKO66_10060	COG2962	Rard protein
AKO66_10070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO66_10075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AKO66_10080	COG0534	Mate efflux family protein
AKO66_10085	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO66_10090	COG0791	NLP P60 protein
AKO66_10090	COG1388	LysM domain
AKO66_10095	COG2032	superoxide dismutase activity
AKO66_10100	COG0714	Associated with various cellular activities
AKO66_10105	COG4548	von Willebrand factor, type A
AKO66_10110	COG0567	Dehydrogenase, E1 component
AKO66_10115	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_10120	COG0385	Bile acid
AKO66_10125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AKO66_10130	COG1657	PFAM Prenyltransferase squalene oxidase
AKO66_10140	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_10160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO66_10165	COG0514	ATP-dependent DNA helicase (RecQ)
AKO66_10170	COG1388	LysM domain
AKO66_10170	COG3584	3D domain protein
AKO66_10180	COG2322	membrane
AKO66_10185	COG0372	Belongs to the citrate synthase family
AKO66_10190	COG2079	MmgE PrpD family protein
AKO66_10195	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AKO66_10200	COG0741	lytic transglycosylase activity
AKO66_10205	COG0531	amino acid
AKO66_10210	COG0640	Transcriptional regulator
AKO66_10220	COG2378	regulation of single-species biofilm formation
AKO66_10225	COG3708	Transcriptional regulator
AKO66_10230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_10235	COG1309	transcriptional regulator
AKO66_10255	COG1994	Peptidase M50
AKO66_10260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AKO66_10265	COG2211	Major facilitator Superfamily
AKO66_10275	COG1940	carbohydrate kinase activity
AKO66_10280	COG2115	Belongs to the xylose isomerase family
AKO66_10285	COG1070	Carbohydrate kinase
AKO66_10295	COG0243	molybdopterin cofactor binding
AKO66_10305	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_10310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO66_10315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO66_10320	COG0454	-acetyltransferase
AKO66_10325	COG0789	Transcriptional regulator
AKO66_10325	COG4978	Transcriptional regulator
AKO66_10330	COG1132	(ABC) transporter
AKO66_10340	COG0583	DNA-binding transcription factor activity
AKO66_10345	COG0067	glutamate synthase
AKO66_10345	COG0070	glutamate synthase
AKO66_10345	COG0069	glutamate synthase activity
AKO66_10350	COG0493	'glutamate synthase
AKO66_10355	COG2223	nitrite transmembrane transporter activity
AKO66_10360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO66_10365	COG0243	molybdopterin cofactor binding
AKO66_10370	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO66_10375	COG2146	nitrite reductase [NAD(P)H] activity
AKO66_10380	COG2323	membrane
AKO66_10385	COG4677	pectinesterase activity
AKO66_10390	COG2027	D-alanyl-D-alanine carboxypeptidase
AKO66_10395	COG0534	Mate efflux family protein
AKO66_10420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_10430	COG1587	Uroporphyrinogen-III synthase
AKO66_10435	COG0586	Pfam SNARE associated Golgi protein
AKO66_10440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AKO66_10445	COG2246	polysaccharide biosynthetic process
AKO66_10450	COG0166	Belongs to the GPI family
AKO66_10470	COG0247	lactate metabolic process
AKO66_10475	COG0277	FAD linked oxidase domain protein
AKO66_10480	COG3835	regulator
AKO66_10490	COG1942	4-Oxalocrotonate Tautomerase
AKO66_10495	COG1349	DNA-binding transcription factor activity
AKO66_10505	COG1649	PFAM Uncharacterised BCR, COG1649
AKO66_10510	COG1960	acyl-CoA dehydrogenase activity
AKO66_10515	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_10520	COG0439	Biotin carboxylase
AKO66_10525	COG0511	ligase activity, forming carbon-carbon bonds
AKO66_10530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO66_10535	COG1024	Enoyl-CoA hydratase
AKO66_10540	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AKO66_10550	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AKO66_10555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO66_10560	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_10580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_10590	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO66_10595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_10595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_10595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_10600	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_10600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_10600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_10610	COG2814	Major facilitator Superfamily
AKO66_10615	COG1846	Transcriptional regulator
AKO66_10620	COG5444	nuclease activity
AKO66_10650	COG1783	phage Terminase large subunit
AKO66_10655	COG5518	Phage portal protein
AKO66_10660	COG2369	cell adhesion
AKO66_10675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_10690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO66_10715	COG1486	melibiose metabolic process
AKO66_10720	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_10725	COG3507	Belongs to the glycosyl hydrolase 43 family
AKO66_10735	COG0745	RESPONSE REGULATOR receiver
AKO66_10740	COG2205	protein histidine kinase activity
AKO66_10755	COG1263	PTS System
AKO66_10755	COG2190	(PTS) system
AKO66_10755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_10760	COG2723	6-phospho-beta-galactosidase activity
AKO66_10765	COG0789	Transcriptional regulator
AKO66_10770	COG0657	acetylesterase activity
AKO66_10810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AKO66_10820	COG0640	Transcriptional regulator
AKO66_10825	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO66_10830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO66_10835	COG0110	maltose O-acetyltransferase activity
AKO66_10840	COG0473	3-isopropylmalate dehydrogenase activity
AKO66_10845	COG0738	Major facilitator superfamily
AKO66_10855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AKO66_10860	COG0187	DNA topoisomerase II activity
AKO66_10865	COG1832	CoA-binding protein
AKO66_10870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AKO66_10875	COG4841	protein insertion into membrane
AKO66_10885	COG0824	Thioesterase
AKO66_10900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_10905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AKO66_10920	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO66_10930	COG4846	Membrane protein involved in cytochrome C biogenesis
AKO66_10935	COG0785	Cytochrome C biogenesis protein
AKO66_10945	COG3763	UPF0154 protein
AKO66_10955	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AKO66_10960	COG4224	UPF0291 protein
AKO66_10965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
AKO66_10970	COG1388	LysM domain
AKO66_10975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AKO66_10990	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_10995	COG3209	COG3209 Rhs family protein
AKO66_11000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AKO66_11005	COG3591	Belongs to the peptidase S1B family
AKO66_11010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
AKO66_11010	COG2124	cytochrome p450
AKO66_11015	COG1309	transcriptional regulator
AKO66_11020	COG2323	membrane
AKO66_11040	COG1556	Lactate utilization protein
AKO66_11045	COG1139	Iron-sulfur cluster binding protein
AKO66_11050	COG0247	lactate metabolic process
AKO66_11060	COG0702	epimerase
AKO66_11065	COG1959	2 iron, 2 sulfur cluster binding
AKO66_11075	COG4876	unkown
AKO66_11080	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AKO66_11085	COG3285	dna ligase
AKO66_11085	COG1793	dna ligase
AKO66_11090	COG3619	membrane
AKO66_11100	COG0457	Tetratricopeptide repeat
AKO66_11125	COG5646	InterPro IPR014922
AKO66_11150	COG5444	nuclease activity
AKO66_11170	COG0604	alcohol dehydrogenase
AKO66_11185	COG0457	Tetratricopeptide repeat
AKO66_11220	COG0174	glutamine synthetase
AKO66_11225	COG0789	Transcriptional regulator
AKO66_11230	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
AKO66_11235	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AKO66_11240	COG0464	growth
AKO66_11250	COG4112	unkown
AKO66_11255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO66_11260	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AKO66_11265	COG1780	Probably involved in ribonucleotide reductase function
AKO66_11280	COG1923	regulation of RNA biosynthetic process
AKO66_11285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AKO66_11310	COG2076	Multidrug Resistance protein
AKO66_11315	COG1764	response to oxidative stress
AKO66_11320	COG4195	phage-related replication protein
AKO66_11325	COG1404	Belongs to the peptidase S8 family
AKO66_11330	COG0457	Tetratricopeptide repeat
AKO66_11335	COG4195	phage-related replication protein
AKO66_11340	COG1329	Transcriptional regulator
AKO66_11360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AKO66_11365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AKO66_11375	COG4550	Control of competence regulator ComK, YlbF/YmcA
AKO66_11380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AKO66_11390	COG0156	8-amino-7-oxononanoate synthase activity
AKO66_11395	COG1063	alcohol dehydrogenase
AKO66_11400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO66_11405	COG2359	stage V sporulation protein S
AKO66_11410	COG1692	metallophosphoesterase
AKO66_11415	COG1418	mRNA catabolic process
AKO66_11420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AKO66_11425	COG1058	Belongs to the CinA family
AKO66_11425	COG1546	Belongs to the CinA family
AKO66_11430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AKO66_11435	COG1426	Protein conserved in bacteria
AKO66_11450	COG0300	oxidoreductase activity
AKO66_11455	COG1033	growth of symbiont in host cell
AKO66_11455	COG2409	Drug exporters of the RND superfamily
AKO66_11465	COG0612	Peptidase, M16
AKO66_11470	COG0612	Peptidase, M16
AKO66_11475	COG1033	growth of symbiont in host cell
AKO66_11475	COG2409	Drug exporters of the RND superfamily
AKO66_11480	COG2814	Major facilitator Superfamily
AKO66_11485	COG2188	Transcriptional regulator
AKO66_11490	COG4980	gas vesicle protein
AKO66_11490	COG1674	ftsk spoiiie
AKO66_11500	COG0740	serine-type endopeptidase activity
AKO66_11505	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO66_11515	COG0527	aspartate kinase activity
AKO66_11520	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AKO66_11525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO66_11530	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AKO66_11535	COG1873	PFAM PRC-barrel domain
AKO66_11540	COG0367	asparagine synthase
AKO66_11585	COG1260	myo-inositol-1-phosphate synthase
AKO66_11590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AKO66_11595	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_11600	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_11620	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
AKO66_11655	COG1132	(ABC) transporter
AKO66_11660	COG1132	(ABC) transporter
AKO66_11675	COG0612	Peptidase, M16
AKO66_11680	COG0726	polysaccharide deacetylase
AKO66_11685	COG1185	polyribonucleotide nucleotidyltransferase activity
AKO66_11690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AKO66_11695	COG0196	riboflavin kinase activity
AKO66_11700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AKO66_11705	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AKO66_11710	COG1550	Protein conserved in bacteria
AKO66_11715	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AKO66_11720	COG1358	cellular component organization or biogenesis
AKO66_11725	COG2740	Nucleic-acid-binding protein implicated in transcription termination
AKO66_11730	COG0195	Participates in both transcription termination and antitermination
AKO66_11735	COG0779	Required for maturation of 30S ribosomal subunits
AKO66_11760	COG2176	DNA-directed DNA polymerase activity
AKO66_11765	COG0442	prolyl-tRNA aminoacylation
AKO66_11770	COG0750	zinc metalloprotease
AKO66_11775	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AKO66_11780	COG4589	Belongs to the CDS family
AKO66_11785	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AKO66_11790	COG0233	cytoplasmic translational termination
AKO66_11795	COG0528	UMP kinase activity
AKO66_11800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AKO66_11815	COG1191	sigma factor activity
AKO66_11825	COG1776	CheC inhibitor of MCP methylation
AKO66_11830	COG0835	chemotaxis
AKO66_11835	COG0643	Histidine kinase
AKO66_11835	COG2198	Histidine kinase
AKO66_11840	COG2201	protein-glutamate methylesterase activity
AKO66_11845	COG0455	bacterial-type flagellum organization
AKO66_11850	COG1419	protein localization to endoplasmic reticulum
AKO66_11855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO66_11860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AKO66_11865	COG1684	flagellar biosynthetic protein fliR
AKO66_11870	COG1987	bacterial-type flagellum assembly
AKO66_11875	COG1338	Plays a role in the flagellum-specific transport system
AKO66_11880	COG3190	flagellar
AKO66_11885	COG2201	protein-glutamate methylesterase activity
AKO66_11890	COG1776	CheC inhibitor of MCP methylation
AKO66_11890	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO66_11895	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO66_11900	COG1580	Controls the rotational direction of flagella during chemotaxis
AKO66_11905	COG1582	Flagellar protein (FlbD)
AKO66_11910	COG4786	Flagellar basal body rod
AKO66_11915	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AKO66_11925	COG3334	PFAM MgtE intracellular
AKO66_11930	COG2882	bacterial-type flagellum organization
AKO66_11935	COG1157	protein secretion by the type III secretion system
AKO66_11940	COG1317	bacterial-type flagellum organization
AKO66_11945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AKO66_11950	COG1766	The M ring may be actively involved in energy transduction
AKO66_11955	COG1677	Flagellar hook-basal body complex protein FliE
AKO66_11960	COG1558	bacterial-type flagellum-dependent cell motility
AKO66_11965	COG1815	bacterial-type flagellum-dependent cell motility
AKO66_11970	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
AKO66_11975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AKO66_11980	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AKO66_11985	COG4974	Belongs to the 'phage' integrase family
AKO66_11990	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AKO66_11995	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO66_12000	COG0758	DNA mediated transformation
AKO66_12005	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AKO66_12010	COG0045	succinate-CoA ligase (ADP-forming) activity
AKO66_12015	COG2257	FlhB HrpN YscU SpaS Family
AKO66_12025	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AKO66_12030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AKO66_12035	COG0335	large ribosomal subunit rRNA binding
AKO66_12040	COG0336	Belongs to the RNA methyltransferase TrmD family
AKO66_12045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AKO66_12055	COG1837	Belongs to the UPF0109 family
AKO66_12060	COG0228	four-way junction DNA binding
AKO66_12065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AKO66_12070	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
AKO66_12075	COG0552	protein localization to endoplasmic reticulum
AKO66_12080	COG1196	nuclear chromosome segregation
AKO66_12090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AKO66_12095	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_12100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AKO66_12105	COG0416	fatty acid biosynthetic process
AKO66_12110	COG1349	DNA-binding transcription factor activity
AKO66_12115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AKO66_12120	COG1760	l-serine dehydratase
AKO66_12125	COG1760	l-serine dehydratase
AKO66_12130	COG1461	Dihydroxyacetone kinase
AKO66_12135	COG1302	Protein conserved in bacteria
AKO66_12140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AKO66_12150	COG1564	THIamine pyrophosphokinase
AKO66_12155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AKO66_12160	COG1162	GTPase activity
AKO66_12165	COG0515	serine threonine protein kinase
AKO66_12165	COG2815	serine threonine protein kinase
AKO66_12170	COG0631	protein serine/threonine phosphatase activity
AKO66_12175	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AKO66_12180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AKO66_12180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AKO66_12185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AKO66_12190	COG0242	peptide deformylase activity
AKO66_12195	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AKO66_12200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AKO66_12205	COG1758	RNA polymerase activity
AKO66_12210	COG0194	GDP metabolic process
AKO66_12215	COG2052	Domain of unknown function (DUF370)
AKO66_12220	COG1561	YicC-like family, N-terminal region
AKO66_12225	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AKO66_12235	COG1648	precorrin-2 dehydrogenase activity
AKO66_12240	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
AKO66_12245	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AKO66_12250	COG0529	Catalyzes the synthesis of activated sulfate
AKO66_12255	COG2046	Belongs to the sulfate adenylyltransferase family
AKO66_12260	COG0306	phosphate transporter
AKO66_12265	COG0175	sulfate reduction
AKO66_12270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AKO66_12275	COG0284	orotidine-5'-phosphate decarboxylase activity
AKO66_12280	COG0167	dihydroorotate dehydrogenase activity
AKO66_12285	COG0543	2 iron, 2 sulfur cluster binding
AKO66_12290	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO66_12295	COG0505	Belongs to the CarA family
AKO66_12300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AKO66_12305	COG0540	Belongs to the ATCase OTCase family
AKO66_12310	COG2233	PERMEase
AKO66_12315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AKO66_12320	COG0564	pseudouridine synthase activity
AKO66_12325	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AKO66_12330	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AKO66_12335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AKO66_12340	COG3599	regulation of cell shape
AKO66_12345	COG2302	S4 RNA-binding domain
AKO66_12350	COG0762	integral membrane protein
AKO66_12355	COG1799	cell septum assembly
AKO66_12360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AKO66_12370	COG1873	PFAM PRC-barrel domain
AKO66_12375	COG1119	ATPase activity
AKO66_12385	COG3732	PTS system glucitol sorbitol-specific
AKO66_12390	COG3730	PTS system glucitol sorbitol-specific
AKO66_12405	COG2390	Transcriptional regulator
AKO66_12410	COG1191	sigma factor activity
AKO66_12415	COG1191	sigma factor activity
AKO66_12425	COG1404	Belongs to the peptidase S8 family
AKO66_12425	COG4412	M6 family metalloprotease domain protein
AKO66_12430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AKO66_12435	COG0849	cell division
AKO66_12440	COG3856	small basic protein
AKO66_12445	COG3879	Bacterial protein of unknown function (DUF881)
AKO66_12450	COG3879	Bacterial protein of unknown function (DUF881)
AKO66_12455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AKO66_12460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AKO66_12465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AKO66_12470	COG0772	Belongs to the SEDS family
AKO66_12475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AKO66_12480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AKO66_12485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AKO66_12490	COG0768	penicillin binding
AKO66_12500	COG4839	cell division protein FtsL
AKO66_12505	COG0275	rRNA processing
AKO66_12510	COG2001	Belongs to the MraZ family
AKO66_12515	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
AKO66_12520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AKO66_12525	COG0454	-acetyltransferase
AKO66_12535	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AKO66_12540	COG1399	metal-binding, possibly nucleic acid-binding protein
AKO66_12550	COG3480	Lon protease (S16) C-terminal proteolytic domain
AKO66_12555	COG1752	Esterase of the alpha-beta hydrolase superfamily
AKO66_12560	COG3314	Sporulation integral membrane protein YlbJ
AKO66_12565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AKO66_12570	COG0742	ribosomal rna small subunit methyltransferase
AKO66_12575	COG4471	UPF0298 protein
AKO66_12580	COG3679	Belongs to the UPF0342 family
AKO66_12600	COG2340	Cysteine-rich secretory protein family
AKO66_12605	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
AKO66_12615	COG3336	cytochrome c oxidase
AKO66_12620	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
AKO66_12625	COG1845	cytochrome c oxidase, subunit III
AKO66_12630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AKO66_12635	COG2010	Cytochrome c
AKO66_12635	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AKO66_12640	COG0109	protoheme IX farnesyltransferase activity
AKO66_12645	COG1612	heme a metabolic process
AKO66_12655	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AKO66_12660	COG0772	Belongs to the SEDS family
AKO66_12665	COG4838	Belongs to the UPF0358 family
AKO66_12670	COG2066	Belongs to the glutaminase family
AKO66_12675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AKO66_12680	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AKO66_12690	COG4896	Protein conserved in bacteria
AKO66_12730	COG0483	inositol monophosphate 1-phosphatase activity
AKO66_12740	COG4493	Belongs to the UPF0637 family
AKO66_12745	COG4476	Belongs to the UPF0223 family
AKO66_12750	COG1982	Orn Lys Arg decarboxylase major
AKO66_12755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_12760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO66_12765	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_12770	COG0022	dehydrogenase e1 component
AKO66_12775	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO66_12790	COG0242	peptide deformylase activity
AKO66_12795	COG0561	phosphatase activity
AKO66_12805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AKO66_12810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO66_12815	COG0569	domain protein
AKO66_12820	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
AKO66_12820	COG2105	PFAM AIG2 family protein
AKO66_12825	COG3852	Histidine kinase
AKO66_12830	COG2002	toxin-antitoxin pair type II binding
AKO66_12835	COG1077	Cell shape determining protein MreB Mrl
AKO66_12840	COG2309	aminopeptidase activity
AKO66_12850	COG0488	(ABC) transporter
AKO66_12860	COG0681	Belongs to the peptidase S26 family
AKO66_12865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_12865	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_12865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_12870	COG1105	Belongs to the carbohydrate kinase PfkB family
AKO66_12875	COG1349	DNA-binding transcription factor activity
AKO66_12880	COG0577	efflux transmembrane transporter activity
AKO66_12885	COG1136	(ABC) transporter
AKO66_12890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AKO66_12905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AKO66_12910	COG0314	molybdopterin synthase activity
AKO66_12915	COG1763	Mo-molybdopterin cofactor biosynthetic process
AKO66_12920	COG0303	'Molybdopterin
AKO66_12925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO66_12930	COG0746	molybdenum cofactor guanylyltransferase activity
AKO66_12945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_12950	COG0450	alkyl hydroperoxide reductase
AKO66_12955	COG0668	transmembrane transport
AKO66_12965	COG1473	amidohydrolase
AKO66_12970	COG2171	N-acyltransferase activity
AKO66_12975	COG0716	FMN binding
AKO66_12985	COG0716	FMN binding
AKO66_12995	COG0583	DNA-binding transcription factor activity
AKO66_13000	COG0517	IMP dehydrogenase activity
AKO66_13010	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
AKO66_13015	COG4703	Protein of unknown function (DUF1797)
AKO66_13020	COG3546	catalase activity
AKO66_13025	COG2200	EAL domain
AKO66_13030	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_13035	COG1408	metallophosphoesterase
AKO66_13040	COG1376	ErfK ybiS ycfS ynhG family protein
AKO66_13045	COG2814	Major facilitator Superfamily
AKO66_13065	COG0835	chemotaxis
AKO66_13065	COG0784	Response regulator, receiver
AKO66_13075	COG1714	RDD family
AKO66_13080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO66_13085	COG0436	Aminotransferase
AKO66_13090	COG4191	Histidine kinase
AKO66_13095	COG0768	penicillin binding
AKO66_13100	COG2340	Cysteine-rich secretory protein family
AKO66_13105	COG2084	Dehydrogenase
AKO66_13115	COG0840	transmembrane signaling receptor activity
AKO66_13120	COG1533	DNA photolyase activity
AKO66_13130	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AKO66_13135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_13140	COG2190	(PTS) system
AKO66_13140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_13140	COG1263	PTS System
AKO66_13145	COG3711	transcriptional antiterminator
AKO66_13150	COG1609	Transcriptional regulator
AKO66_13155	COG0006	proline dipeptidase activity
AKO66_13160	COG2217	Heavy metal translocating P-type atpase
AKO66_13165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_13170	COG2244	polysaccharide biosynthetic process
AKO66_13175	COG3773	Cell wall hydrolase
AKO66_13185	COG4873	Protein conserved in bacteria
AKO66_13195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AKO66_13200	COG0602	queuosine metabolic process
AKO66_13205	COG0720	synthase
AKO66_13210	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AKO66_13215	COG3949	Membrane
AKO66_13220	COG0542	response to heat
AKO66_13225	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AKO66_13230	COG1360	Flagellar Motor Protein
AKO66_13235	COG1846	Transcriptional regulator
AKO66_13240	COG3852	Histidine kinase
AKO66_13250	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AKO66_13255	COG0235	Class ii aldolase
AKO66_13260	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
AKO66_13265	COG1850	ribulose-bisphosphate carboxylase activity
AKO66_13270	COG0436	Aminotransferase
AKO66_13275	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
AKO66_13280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AKO66_13285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AKO66_13290	COG5002	protein histidine kinase activity
AKO66_13295	COG3594	Acyltransferase
AKO66_13305	COG2323	membrane
AKO66_13310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AKO66_13315	COG0501	Belongs to the peptidase M48B family
AKO66_13335	COG1191	sigma factor activity
AKO66_13340	COG0861	Integral membrane protein TerC family
AKO66_13345	COG0586	Pfam SNARE associated Golgi protein
AKO66_13350	COG3300	MHYT domain
AKO66_13350	COG5001	Diguanylate cyclase
AKO66_13355	COG1846	Transcriptional regulator
AKO66_13365	COG0789	Transcriptional regulator
AKO66_13375	COG0583	DNA-binding transcription factor activity
AKO66_13385	COG2239	Acts as a magnesium transporter
AKO66_13395	COG3212	peptidase
AKO66_13400	COG3212	peptidase
AKO66_13405	COG3850	Histidine kinase
AKO66_13405	COG5002	protein histidine kinase activity
AKO66_13410	COG0745	RESPONSE REGULATOR receiver
AKO66_13425	COG1404	Belongs to the peptidase S8 family
AKO66_13430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AKO66_13435	COG0590	tRNA wobble adenosine to inosine editing
AKO66_13440	COG1764	response to oxidative stress
AKO66_13445	COG1846	Transcriptional regulator
AKO66_13450	COG1764	response to oxidative stress
AKO66_13460	COG0457	Tetratricopeptide repeat
AKO66_13465	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AKO66_13470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AKO66_13475	COG0788	formyltetrahydrofolate deformylase activity
AKO66_13485	COG2076	Multidrug Resistance protein
AKO66_13490	COG2076	Multidrug Resistance protein
AKO66_13500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_13515	COG1695	Transcriptional regulator
AKO66_13520	COG1607	acyl-coa hydrolase
AKO66_13525	COG1834	amidinotransferase
AKO66_13530	COG4608	Belongs to the ABC transporter superfamily
AKO66_13535	COG0791	NLP P60 protein
AKO66_13540	COG4948	Mandelate Racemase Muconate Lactonizing
AKO66_13545	COG1619	proteins homologs of microcin C7 resistance protein MccF
AKO66_13550	COG4166	transmembrane transport
AKO66_13555	COG0444	Belongs to the ABC transporter superfamily
AKO66_13560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_13565	COG0601	transmembrane transport
AKO66_13570	COG2362	D-Aminopeptidase
AKO66_13575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AKO66_13580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AKO66_13585	COG0346	lactoylglutathione lyase activity
AKO66_13590	COG0531	amino acid
AKO66_13600	COG2390	Transcriptional regulator
AKO66_13605	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_13610	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_13615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AKO66_13620	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_13625	COG0022	dehydrogenase e1 component
AKO66_13625	COG0508	dehydrogenase complex catalyzes the overall conversion of
AKO66_13630	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AKO66_13635	COG1063	alcohol dehydrogenase
AKO66_13650	COG3775	system Galactitol-specific IIC component
AKO66_13665	COG4208	sulfate ABC transporter
AKO66_13675	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AKO66_13680	COG0405	Gamma-glutamyltransferase
AKO66_13690	COG1392	Phosphate transport regulator
AKO66_13695	COG0306	phosphate transporter
AKO66_13710	COG5632	N-Acetylmuramoyl-L-alanine amidase
AKO66_13710	COG3409	Peptidoglycan-binding domain 1 protein
AKO66_13720	COG2856	Zn peptidase
AKO66_13725	COG4195	phage-related replication protein
AKO66_13745	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_13750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_13755	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_13760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_13770	COG1309	transcriptional regulator
AKO66_13780	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO66_13815	COG2807	transmembrane transport
AKO66_13820	COG0583	DNA-binding transcription factor activity
AKO66_13840	COG0583	DNA-binding transcription factor activity
AKO66_13865	COG0457	Tetratricopeptide repeat
AKO66_13875	COG2364	Membrane
AKO66_13880	COG2153	protein acetylation
AKO66_13885	COG0457	Tetratricopeptide repeat
AKO66_13895	COG0583	DNA-binding transcription factor activity
AKO66_13905	COG2807	transmembrane transport
AKO66_13925	COG0825	malonyl-CoA metabolic process
AKO66_13930	COG0113	porphobilinogen synthase activity
AKO66_14065	COG0626	cystathionine gamma-synthase activity
AKO66_14070	COG0626	cystathionine gamma-synthase activity
AKO66_14075	COG2382	esterase
AKO66_14080	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AKO66_14085	COG2153	protein acetylation
AKO66_14095	COG0210	DNA helicase
AKO66_14145	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AKO66_14150	COG0351	phosphomethylpyrimidine kinase
AKO66_14155	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AKO66_14160	COG2022	thiamine diphosphate biosynthetic process
AKO66_14165	COG2104	thiamine diphosphate biosynthetic process
AKO66_14175	COG0352	thiamine-phosphate diphosphorylase activity
AKO66_14180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AKO66_14185	COG0569	domain protein
AKO66_14185	COG0475	glutathione-regulated potassium exporter activity
AKO66_14190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AKO66_14195	COG0564	pseudouridine synthase activity
AKO66_14200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AKO66_14205	COG2357	RelA SpoT domain protein
AKO66_14215	COG4116	CYTH
AKO66_14220	COG0741	lytic transglycosylase activity
AKO66_14225	COG2346	COG2346, Truncated hemoglobins
AKO66_14235	COG1164	Oligoendopeptidase f
AKO66_14245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AKO66_14250	COG4862	establishment of competence for transformation
AKO66_14255	COG0861	Integral membrane protein TerC family
AKO66_14260	COG1393	Belongs to the ArsC family
AKO66_14265	COG0456	acetyltransferase
AKO66_14275	COG4608	Belongs to the ABC transporter superfamily
AKO66_14280	COG0444	Belongs to the ABC transporter superfamily
AKO66_14285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_14290	COG0601	transmembrane transport
AKO66_14295	COG4166	transmembrane transport
AKO66_14300	COG0180	Tryptophanyl-tRNA synthetase
AKO66_14310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AKO66_14315	COG0601	transmembrane transport
AKO66_14325	COG4608	Belongs to the ABC transporter superfamily
AKO66_14330	COG0444	Belongs to the ABC transporter superfamily
AKO66_14335	COG5504	Zn-dependent protease
AKO66_14340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO66_14345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AKO66_14360	COG1744	ABC transporter substrate-binding protein PnrA-like
AKO66_14370	COG2267	carboxylic ester hydrolase activity
AKO66_14380	COG2814	Major facilitator Superfamily
AKO66_14390	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AKO66_14395	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AKO66_14400	COG0505	Belongs to the CarA family
AKO66_14405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AKO66_14410	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AKO66_14420	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AKO66_14425	COG2271	Major facilitator Superfamily
AKO66_14430	COG0277	FAD linked oxidase domain protein
AKO66_14435	COG2151	metal-sulfur cluster biosynthetic enzyme
AKO66_14440	COG1073	alpha beta
AKO66_14445	COG0561	phosphatase activity
AKO66_14465	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_14470	COG1307	EDD domain protein, DegV family
AKO66_14475	COG0840	transmembrane signaling receptor activity
AKO66_14485	COG2996	Protein conserved in bacteria
AKO66_14490	COG1666	GTP binding
AKO66_14495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AKO66_14495	COG0646	methionine synthase
AKO66_14500	COG1410	methionine synthase
AKO66_14500	COG0646	methionine synthase
AKO66_14535	COG0076	glutamate decarboxylase activity
AKO66_14560	COG2207	Transcriptional regulator
AKO66_14560	COG1917	Cupin 2, conserved barrel domain protein
AKO66_14565	COG0534	Mate efflux family protein
AKO66_14570	COG1562	ergosterol biosynthetic process
AKO66_14585	COG0367	asparagine synthase
AKO66_14600	COG0179	Fumarylacetoacetate (FAA) hydrolase
AKO66_14615	COG5337	Spore coat protein CotH
AKO66_14655	COG1403	HNH endonuclease
AKO66_14660	COG0419	ATPase involved in DNA repair
AKO66_14665	COG0420	3'-5' exonuclease activity
AKO66_14670	COG1074	ATP-dependent DNA helicase activity
AKO66_14675	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
AKO66_14680	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
AKO66_14685	COG2259	Doxx family
AKO66_14700	COG3180	Ammonia monooxygenase
AKO66_14705	COG0681	Belongs to the peptidase S26 family
AKO66_14710	COG0398	Pfam SNARE associated Golgi protein
AKO66_14725	COG1316	TRANSCRIPTIONal
AKO66_14730	COG4607	ABC-type enterochelin transport system periplasmic component
AKO66_14735	COG4604	ABC transporter, ATP-binding protein
AKO66_14740	COG4605	iron ion homeostasis
AKO66_14745	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AKO66_14750	COG2732	(Barnase) inhibitor
AKO66_14755	COG2814	Major facilitator Superfamily
AKO66_14760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_14775	COG4903	ComK protein
AKO66_14785	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_14790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AKO66_14790	COG0723	plastoquinol--plastocyanin reductase activity
AKO66_14795	COG0840	transmembrane signaling receptor activity
AKO66_14800	COG0406	alpha-ribazole phosphatase activity
AKO66_14805	COG1404	Belongs to the peptidase S8 family
AKO66_14810	COG0501	Belongs to the peptidase M48B family
AKO66_14820	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_14825	COG0095	Lipoate-protein ligase
AKO66_14830	COG1234	tRNA 3'-trailer cleavage
AKO66_14835	COG1301	dicarboxylic acid transport
AKO66_14840	COG1363	Peptidase, m42
AKO66_14845	COG1511	domain protein
AKO66_14850	COG1309	transcriptional regulator
AKO66_14865	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AKO66_14870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AKO66_14875	COG2329	Antibiotic biosynthesis monooxygenase
AKO66_14885	COG1473	amidohydrolase
AKO66_14895	COG4473	ABC transporter
AKO66_14900	COG1131	(ABC) transporter
AKO66_14905	COG0537	adenosine 5'-monophosphoramidase activity
AKO66_14910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AKO66_14925	COG4980	gas vesicle protein
AKO66_14930	COG1846	Transcriptional regulator
AKO66_14950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AKO66_14960	COG3481	metal-dependent phosphohydrolase, HD sub domain
AKO66_14965	COG4717	serine-type aminopeptidase activity
AKO66_14970	COG0420	3'-5' exonuclease activity
AKO66_14980	COG1024	Enoyl-CoA hydratase
AKO66_14990	COG0490	domain, Protein
AKO66_14995	COG0475	glutathione-regulated potassium exporter activity
AKO66_15005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AKO66_15010	COG0561	phosphatase activity
AKO66_15015	COG3679	Belongs to the UPF0342 family
AKO66_15020	COG4399	Belongs to the UPF0754 family
AKO66_15025	COG0189	ligase activity
AKO66_15030	COG0189	ligase activity
AKO66_15040	COG2508	Transcriptional regulator
AKO66_15045	COG3842	ATPase activity
AKO66_15055	COG0702	epimerase
AKO66_15060	COG1132	(ABC) transporter
AKO66_15065	COG1132	(ABC) transporter
AKO66_15070	COG0589	response to stress
AKO66_15075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AKO66_15080	COG0726	polysaccharide deacetylase
AKO66_15085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AKO66_15090	COG0668	transmembrane transport
AKO66_15095	COG0584	glycerophosphoryl diester phosphodiesterase
AKO66_15100	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AKO66_15115	COG1253	flavin adenine dinucleotide binding
AKO66_15120	COG0789	Transcriptional regulator
AKO66_15125	COG1253	flavin adenine dinucleotide binding
AKO66_15130	COG0204	Acyl-transferase
AKO66_15135	COG1595	DNA-templated transcription, initiation
AKO66_15150	COG0531	amino acid
AKO66_15155	COG0791	NLP P60 protein
AKO66_15155	COG1388	LysM domain
AKO66_15160	COG1785	Belongs to the alkaline phosphatase family
AKO66_15165	COG2719	SpoVR family
AKO66_15170	COG1017	nitric oxide dioxygenase activity
AKO66_15170	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AKO66_15175	COG1959	2 iron, 2 sulfur cluster binding
AKO66_15180	COG0753	catalase activity
AKO66_15195	COG2197	response regulator
AKO66_15200	COG2203	Gaf domain
AKO66_15200	COG4585	Histidine kinase
AKO66_15205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO66_15210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AKO66_15215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AKO66_15220	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AKO66_15225	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
AKO66_15230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO66_15235	COG3835	regulator
AKO66_15255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO66_15255	COG3153	acetyltransferase
AKO66_15260	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AKO66_15270	COG0564	pseudouridine synthase activity
AKO66_15275	COG3764	Sortase (surface protein transpeptidase)
AKO66_15280	COG0737	Belongs to the 5'-nucleotidase family
AKO66_15280	COG1525	nuclease
AKO66_15280	COG4085	toxin activity
AKO66_15285	COG5002	protein histidine kinase activity
AKO66_15290	COG5577	PFAM Coat F domain
AKO66_15315	COG3706	GGDEF domain
AKO66_15320	COG1278	Cold shock
AKO66_15330	COG0655	NAD(P)H dehydrogenase (quinone) activity
AKO66_15335	COG2814	Major facilitator Superfamily
AKO66_15340	COG1566	PFAM secretion protein HlyD family protein
AKO66_15345	COG2718	Belongs to the UPF0229 family
AKO66_15350	COG2766	serine protein kinase
AKO66_15355	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AKO66_15365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AKO66_15370	COG3382	B3 4 domain protein
AKO66_15400	COG1131	(ABC) transporter
AKO66_15415	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AKO66_15420	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AKO66_15425	COG1116	anion transmembrane transporter activity
AKO66_15440	COG0681	Belongs to the peptidase S26 family
AKO66_15445	COG1368	sulfuric ester hydrolase activity
AKO66_15600	COG0735	belongs to the Fur family
AKO66_15605	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AKO66_15610	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AKO66_15615	COG4129	membrane
AKO66_15630	COG0747	negative chemotaxis
AKO66_15635	COG4608	Belongs to the ABC transporter superfamily
AKO66_15640	COG0444	Belongs to the ABC transporter superfamily
AKO66_15645	COG1132	(ABC) transporter
AKO66_15650	COG3557	Belongs to the UPF0374 family
AKO66_15665	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_15675	COG1194	a g-specific adenine glycosylase
AKO66_15680	COG1988	membrane-bound metal-dependent
AKO66_15690	COG1191	sigma factor activity
AKO66_15695	COG2140	Oxalate decarboxylase
AKO66_15710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AKO66_15715	COG4485	Bacterial membrane protein, YfhO
AKO66_15720	COG0463	Glycosyl transferase, family 2
AKO66_15740	COG2137	regulation of response to DNA damage stimulus
AKO66_15745	COG1090	epimerase
AKO66_15755	COG0778	Nitroreductase
AKO66_15775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AKO66_15775	COG0392	lysyltransferase activity
AKO66_15780	COG1846	Transcriptional regulator
AKO66_15790	COG2318	DinB family
AKO66_15810	COG1595	DNA-templated transcription, initiation
AKO66_15815	COG1742	UPF0060 membrane protein
AKO66_15820	COG1132	(ABC) transporter
AKO66_15825	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AKO66_15830	COG2169	Transcriptional regulator
AKO66_15835	COG0492	ferredoxin-NADP+ reductase activity
AKO66_15840	COG2755	lipolytic protein G-D-S-L family
AKO66_15845	COG4637	Psort location Cytoplasmic, score
AKO66_15855	COG1309	transcriptional regulator
AKO66_15860	COG2076	Multidrug Resistance protein
AKO66_15865	COG2076	Multidrug Resistance protein
AKO66_15920	COG2814	Major facilitator Superfamily
AKO66_15925	COG0789	Transcriptional regulator
AKO66_15930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AKO66_15935	COG1942	4-Oxalocrotonate Tautomerase
AKO66_15940	COG0583	DNA-binding transcription factor activity
AKO66_15955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO66_15960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AKO66_15970	COG0598	Magnesium transport protein CorA
AKO66_15980	COG0726	polysaccharide deacetylase
AKO66_15990	COG0535	radical SAM domain protein
AKO66_15995	COG0668	transmembrane transport
AKO66_16005	COG0217	transcriptional regulatory protein
AKO66_16015	COG0387	Pfam Sodium calcium exchanger
AKO66_16025	COG0477	Major facilitator Superfamily
AKO66_16030	COG1295	ribonuclease BN
AKO66_16035	COG4980	gas vesicle protein
AKO66_16040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AKO66_16045	COG1115	amino acid carrier protein
AKO66_16050	COG4840	Belongs to the UPF0435 family
AKO66_16055	COG0693	protein deglycase activity
AKO66_16060	COG0737	Belongs to the 5'-nucleotidase family
AKO66_16070	COG2188	Transcriptional regulator
AKO66_16075	COG0366	Alpha amylase catalytic
AKO66_16080	COG1263	PTS System
AKO66_16080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_16095	COG0076	glutamate decarboxylase activity
AKO66_16100	COG1368	sulfuric ester hydrolase activity
AKO66_16115	COG3739	integral membrane protein
AKO66_16120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_16120	COG1263	PTS System
AKO66_16125	COG0024	Methionine aminopeptidase
AKO66_16130	COG2258	MOSC domain
AKO66_16135	COG1254	Belongs to the acylphosphatase family
AKO66_16145	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
AKO66_16150	COG1695	Transcriptional regulator
AKO66_16155	COG3479	Phenolic acid decarboxylase
AKO66_16165	COG2851	Citrate transporter
AKO66_16170	COG3181	Tripartite tricarboxylate transporter family receptor
AKO66_16175	COG4565	transcriptional regulatory protein
AKO66_16180	COG3290	protein histidine kinase activity
AKO66_16190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_16190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AKO66_16200	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AKO66_16205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_16205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AKO66_16225	COG2130	NADP-dependent
AKO66_16230	COG0513	Belongs to the DEAD box helicase family
AKO66_16235	COG0488	(ABC) transporter
AKO66_16240	COG2814	Major facilitator Superfamily
AKO66_16245	COG0789	Transcriptional regulator
AKO66_16250	COG1469	GTP cyclohydrolase I activity
AKO66_16255	COG0488	(ABC) transporter
AKO66_16260	COG0463	Glycosyl transferase, family 2
AKO66_16260	COG0457	Tetratricopeptide repeat
AKO66_16265	COG0531	amino acid
AKO66_16280	COG0071	Belongs to the small heat shock protein (HSP20) family
AKO66_16295	COG0471	metal ion transport
AKO66_16305	COG2223	nitrite transmembrane transporter activity
AKO66_16310	COG1442	glycosyl transferase family 8
AKO66_16315	COG1216	Glycosyl transferase, family 2
AKO66_16320	COG1442	glycosyl transferase family 8
AKO66_16325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AKO66_16330	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AKO66_16355	COG2211	Major facilitator Superfamily
AKO66_16365	COG1486	melibiose metabolic process
AKO66_16380	COG0492	ferredoxin-NADP+ reductase activity
AKO66_16385	COG1959	2 iron, 2 sulfur cluster binding
AKO66_16400	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AKO66_16405	COG5444	nuclease activity
AKO66_16415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AKO66_16420	COG1597	lipid kinase activity
AKO66_16425	COG1957	nucleoside hydrolase
AKO66_16430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AKO66_16435	COG1309	transcriptional regulator
AKO66_16440	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO66_16445	COG0154	amidase activity
AKO66_16450	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AKO66_16455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AKO66_16460	COG1285	pathogenesis
AKO66_16465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AKO66_16470	COG4851	CamS sex pheromone cAM373 precursor
AKO66_16475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AKO66_16480	COG0210	DNA helicase
AKO66_16485	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
AKO66_16500	COG0069	glutamate synthase activity
AKO66_16510	COG4496	protein, YerC YecD
AKO66_16515	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AKO66_16525	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AKO66_16530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AKO66_16535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AKO66_16540	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AKO66_16560	COG0151	Belongs to the GarS family
AKO66_16565	COG0138	bifunctional purine biosynthesis protein purh
AKO66_16570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AKO66_16575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AKO66_16580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AKO66_16585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO66_16590	COG0047	phosphoribosylformylglycinamidine synthase activity
AKO66_16595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AKO66_16600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AKO66_16605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AKO66_16610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
AKO66_16615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AKO66_16625	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AKO66_16630	COG3064	Membrane
AKO66_16635	COG5583	Uncharacterized small protein (DUF2292)
AKO66_16640	COG2252	PERMEase
AKO66_16645	COG0583	DNA-binding transcription factor activity
AKO66_16650	COG2814	Major facilitator Superfamily
AKO66_16660	COG1595	DNA-templated transcription, initiation
AKO66_16680	COG3279	Response regulator of the LytR AlgR family
AKO66_16710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AKO66_16720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AKO66_16730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AKO66_16730	COG0519	Catalyzes the synthesis of GMP from XMP
AKO66_16735	COG1305	Transglutaminase-like
AKO66_16740	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
AKO66_16745	COG0714	Associated with various cellular activities
AKO66_16750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AKO66_16755	COG1113	amino acid transport
AKO66_16760	COG2132	Multicopper oxidase
AKO66_16770	COG0823	Involved in the tonB-independent uptake of proteins
AKO66_16775	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AKO66_16800	COG1876	peptidase activity
AKO66_16805	COG2808	Putative FMN-binding domain
AKO66_16810	COG1846	Transcriptional regulator
AKO66_16835	COG0459	protein refolding
AKO66_16840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AKO66_16845	COG1266	CAAX protease self-immunity
AKO66_16860	COG0805	protein transport
AKO66_16865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AKO66_16870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
AKO66_16875	COG0315	cyclic pyranopterin monophosphate synthase activity
AKO66_16880	COG0488	(ABC) transporter
AKO66_16885	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AKO66_16890	COG0456	acetyltransferase
AKO66_16895	COG1214	PFAM Peptidase M22, glycoprotease
AKO66_16900	COG0802	atpase or kinase
AKO66_16905	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AKO66_16955	COG1301	dicarboxylic acid transport
AKO66_16965	COG0697	spore germination
AKO66_16970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AKO66_16990	COG0456	acetyltransferase
AKO66_17000	COG1396	sequence-specific DNA binding
AKO66_17015	COG0778	Nitroreductase
AKO66_17020	COG1846	Transcriptional regulator
AKO66_17025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AKO66_17030	COG1309	transcriptional regulator
AKO66_17075	COG2814	Major facilitator Superfamily
AKO66_17100	COG0252	asparaginase activity
AKO66_17110	COG4221	oxidoreductase activity
AKO66_17125	COG0477	Major facilitator Superfamily
AKO66_17140	COG0789	Transcriptional regulator
AKO66_17145	COG1064	alcohol dehydrogenase
AKO66_17150	COG1329	Transcriptional regulator
AKO66_17155	COG1278	Cold shock
AKO66_17170	COG0433	COG0433 Predicted ATPase
AKO66_17210	COG3091	SprT-like family
AKO66_17215	COG2183	response to ionizing radiation
AKO66_17220	COG2208	phosphoserine phosphatase activity
AKO66_17225	COG1191	sigma factor activity
AKO66_17230	COG2172	sigma factor antagonist activity
AKO66_17235	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_17240	COG2208	phosphoserine phosphatase activity
AKO66_17245	COG2172	sigma factor antagonist activity
AKO66_17250	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_17255	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_17260	COG2337	Toxic component of a toxin-antitoxin (TA) module
AKO66_17265	COG0864	Transcriptional regulator
AKO66_17270	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AKO66_17275	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AKO66_17280	COG0736	holo-[acyl-carrier-protein] synthase activity
AKO66_17285	COG0705	Rhomboid family
AKO66_17290	COG3428	Bacterial PH domain
AKO66_17295	COG3402	PFAM membrane-flanked domain
AKO66_17300	COG0513	Belongs to the DEAD box helicase family
AKO66_17315	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AKO66_17320	COG1181	Belongs to the D-alanine--D-alanine ligase family
AKO66_17325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_17340	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
AKO66_17345	COG1131	(ABC) transporter
AKO66_17350	COG1301	dicarboxylic acid transport
AKO66_17355	COG0628	permease
AKO66_17360	COG1301	dicarboxylic acid transport
AKO66_17365	COG4565	transcriptional regulatory protein
AKO66_17370	COG3290	protein histidine kinase activity
AKO66_17375	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AKO66_17380	COG2217	Heavy metal translocating P-type atpase
AKO66_17385	COG2261	transglycosylase associated protein
AKO66_17390	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO66_17395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_17415	COG5444	nuclease activity
AKO66_17420	COG0028	Belongs to the TPP enzyme family
AKO66_17425	COG0531	amino acid
AKO66_17435	COG1215	transferase activity, transferring glycosyl groups
AKO66_17440	COG5298	Protein conserved in bacteria
AKO66_17445	COG3706	GGDEF domain
AKO66_17450	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AKO66_17455	COG0551	DNA topoisomerase type I activity
AKO66_17455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AKO66_17460	COG2814	Major facilitator Superfamily
AKO66_17480	COG3871	stress protein (general stress protein 26)
AKO66_17485	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_17490	COG2226	methyltransferase
AKO66_17495	COG3711	transcriptional antiterminator
AKO66_17505	COG2755	lipolytic protein G-D-S-L family
AKO66_17510	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AKO66_17515	COG1414	Transcriptional regulator
AKO66_17520	COG1984	allophanate hydrolase subunit 2
AKO66_17525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AKO66_17530	COG4336	lyase activity
AKO66_17535	COG1914	H( )-stimulated, divalent metal cation uptake system
AKO66_17540	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AKO66_17545	COG0457	Tetratricopeptide repeat
AKO66_17560	COG0561	phosphatase activity
AKO66_17570	COG0346	lactoylglutathione lyase activity
AKO66_17605	COG0840	transmembrane signaling receptor activity
AKO66_17610	COG0246	Mannitol dehydrogenase
AKO66_17615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_17620	COG2213	PTS system mannitol-specific
AKO66_17625	COG2372	response to copper ion
AKO66_17625	COG1276	copper resistance
AKO66_17630	COG4549	nuclear export factor GLE1
AKO66_17635	COG2249	NAD(P)H dehydrogenase (quinone) activity
AKO66_17640	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_17645	COG0531	amino acid
AKO66_17650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AKO66_17655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_17660	COG0583	DNA-binding transcription factor activity
AKO66_17670	COG0640	Transcriptional regulator
AKO66_17680	COG1309	transcriptional regulator
AKO66_17685	COG2814	Major facilitator Superfamily
AKO66_17690	COG0527	aspartate kinase activity
AKO66_17695	COG1366	Belongs to the anti-sigma-factor antagonist family
AKO66_17700	COG3850	Histidine kinase
AKO66_17700	COG5002	protein histidine kinase activity
AKO66_17705	COG0745	RESPONSE REGULATOR receiver
AKO66_17720	COG2079	MmgE PrpD family protein
AKO66_17730	COG1126	abc transporter atp-binding protein
AKO66_17735	COG0765	amino acid transport
AKO66_17740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_17755	COG5434	Belongs to the glycosyl hydrolase 28 family
AKO66_17760	COG3104	oligopeptide transport
AKO66_17765	COG0833	amino acid
AKO66_17770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_17775	COG0765	amino acid transport
AKO66_17780	COG1126	abc transporter atp-binding protein
AKO66_17785	COG2364	Membrane
AKO66_17795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AKO66_17800	COG0697	spore germination
AKO66_17805	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AKO66_17820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_17825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_17830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AKO66_17840	COG1176	ABC-type spermidine putrescine transport system, permease component I
AKO66_17845	COG3842	ATPase activity
AKO66_17870	COG3209	COG3209 Rhs family protein
AKO66_17875	COG3290	protein histidine kinase activity
AKO66_17875	COG0840	transmembrane signaling receptor activity
AKO66_17885	COG2746	aminoglycoside 3-N-acetyltransferase activity
AKO66_17890	COG1522	sequence-specific DNA binding
AKO66_17895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AKO66_17905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AKO66_17910	COG0765	amino acid transport
AKO66_17915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AKO66_17920	COG2508	Transcriptional regulator
AKO66_17925	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_17930	COG0506	proline dehydrogenase activity
AKO66_17935	COG3541	Predicted nucleotidyltransferase
AKO66_17945	COG3458	cephalosporin-C deacetylase activity
AKO66_17950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AKO66_17955	COG0583	DNA-binding transcription factor activity
AKO66_17960	COG2226	methyltransferase
AKO66_17965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AKO66_17970	COG1414	Transcriptional regulator
AKO66_17980	COG2271	Major facilitator Superfamily
AKO66_17985	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AKO66_17995	COG0028	Belongs to the TPP enzyme family
AKO66_18000	COG0710	3-dehydroquinate dehydratase activity
AKO66_18005	COG1012	belongs to the aldehyde dehydrogenase family
AKO66_18015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AKO66_18020	COG3665	Urea carboxylase-associated protein
AKO66_18025	COG1113	amino acid transport
AKO66_18030	COG3403	YqcI/YcgG family
AKO66_18045	COG1280	lysine exporter protein (LysE YggA)
AKO66_18050	COG0738	Major facilitator superfamily
AKO66_18055	COG0673	inositol 2-dehydrogenase activity
AKO66_18060	COG0561	phosphatase activity
AKO66_18065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AKO66_18070	COG1609	Transcriptional regulator
AKO66_18075	COG1620	l-lactate permease
AKO66_18080	COG0039	L-malate dehydrogenase activity
AKO66_18085	COG1288	antiporter activity
AKO66_18090	COG1473	amidohydrolase
AKO66_18105	COG2113	Glycine betaine
AKO66_18110	COG4176	ABC-type proline glycine betaine transport system permease component
AKO66_18115	COG4175	Glycine betaine
AKO66_18115	COG0517	IMP dehydrogenase activity
AKO66_18120	COG3853	Toxic anion resistance protein (TelA)
AKO66_18150	COG0861	Integral membrane protein TerC family
AKO66_18155	COG2310	stress, protein
AKO66_18160	COG2310	stress, protein
AKO66_18165	COG2310	stress, protein
AKO66_18170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AKO66_18180	COG1028	Short-chain dehydrogenase reductase Sdr
AKO66_18185	COG3773	Cell wall hydrolase
AKO66_18200	COG1668	transmembrane transport
AKO66_18205	COG4555	ABC transporter
AKO66_18210	COG3279	Response regulator of the LytR AlgR family
AKO66_18215	COG3290	protein histidine kinase activity
AKO66_18220	COG0667	Aldo Keto reductase
AKO66_18230	COG4585	Histidine kinase
AKO66_18235	COG2197	response regulator
AKO66_18245	COG1405	negative regulation of cell septum assembly
AKO66_18245	COG3012	SEC-C Motif Domain Protein
AKO66_18250	COG0784	Response regulator, receiver
AKO66_18255	COG4191	Histidine kinase
AKO66_18260	COG2066	Belongs to the glutaminase family
AKO66_18265	COG1115	amino acid carrier protein
AKO66_18270	COG0596	Alpha beta hydrolase
AKO66_18280	COG0531	amino acid
AKO66_18285	COG0318	PFAM AMP-dependent synthetase and ligase
AKO66_18290	COG1846	Transcriptional regulator
AKO66_18295	COG1063	alcohol dehydrogenase
AKO66_18300	COG1917	Cupin 2, conserved barrel domain protein
AKO66_18305	COG1309	transcriptional regulator
AKO66_18315	COG1404	Belongs to the peptidase S8 family
AKO66_18335	COG2814	Major facilitator Superfamily
AKO66_18345	COG1695	Transcriptional regulator
AKO66_18350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
AKO66_18355	COG2040	homocysteine
AKO66_18360	COG0833	amino acid
AKO66_18370	COG1404	Belongs to the peptidase S8 family
AKO66_18380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_18385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AKO66_18390	COG0383	alpha-mannosidase activity
AKO66_18395	COG1940	carbohydrate kinase activity
AKO66_18400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AKO66_18400	COG3711	transcriptional antiterminator
AKO66_18415	COG2723	6-phospho-beta-galactosidase activity
AKO66_18420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_18420	COG2190	(PTS) system
AKO66_18420	COG1263	PTS System
AKO66_18425	COG3711	transcriptional antiterminator
AKO66_18435	COG0531	amino acid
AKO66_18445	COG0371	Dehydrogenase
AKO66_18450	COG0656	L-ascorbic acid biosynthetic process
AKO66_18460	COG1683	Conserved Protein
AKO66_18470	COG1846	Transcriptional regulator
AKO66_18485	COG2814	Major facilitator Superfamily
AKO66_18490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AKO66_18495	COG0730	response to heat
AKO66_18500	COG0425	Belongs to the sulfur carrier protein TusA family
AKO66_18505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AKO66_18505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_18510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AKO66_18510	COG0425	Belongs to the sulfur carrier protein TusA family
AKO66_18520	COG2210	Belongs to the sulfur carrier protein TusA family
AKO66_18525	COG1937	Protein conserved in bacteria
AKO66_18540	COG0640	Transcriptional regulator
AKO66_18550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AKO66_18555	COG1331	Highly conserved protein containing a thioredoxin domain
AKO66_18565	COG2271	Major facilitator Superfamily
AKO66_18570	COG0584	glycerophosphoryl diester phosphodiesterase
AKO66_18575	COG1113	amino acid transport
AKO66_18590	COG1309	transcriptional regulator
AKO66_18595	COG2207	Transcriptional regulator
AKO66_18600	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AKO66_18610	COG1476	TRANSCRIPTIONal
AKO66_18630	COG2311	Membrane
AKO66_18640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AKO66_18645	COG1413	lyase activity
AKO66_18655	COG1131	(ABC) transporter
AKO66_18660	COG1266	CAAX protease self-immunity
AKO66_18665	COG0535	radical SAM domain protein
AKO66_18680	COG1695	Transcriptional regulator
AKO66_18690	COG1136	(ABC) transporter
AKO66_18700	COG1131	(ABC) transporter
AKO66_18720	COG3852	Histidine kinase
AKO66_18725	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AKO66_18730	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AKO66_18735	COG4856	YbbR-like protein
AKO66_18740	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AKO66_18745	COG5662	AntiSigma factor
AKO66_18750	COG1595	DNA-templated transcription, initiation
AKO66_18785	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
AKO66_18790	COG1737	Transcriptional regulator
AKO66_18795	COG1263	PTS System
AKO66_18795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AKO66_18800	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AKO66_18805	COG1472	Belongs to the glycosyl hydrolase 3 family
AKO66_18810	COG3876	Protein conserved in bacteria
AKO66_18815	COG0385	Bile acid
AKO66_18820	COG0659	secondary active sulfate transmembrane transporter activity
AKO66_18825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AKO66_18865	COG0726	polysaccharide deacetylase
AKO66_18870	COG2194	sulfuric ester hydrolase activity
AKO66_18880	COG0489	protein tyrosine kinase activity
AKO66_18885	COG0860	N-Acetylmuramoyl-L-alanine amidase
AKO66_18910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AKO66_18915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AKO66_18920	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AKO66_18925	COG0101	tRNA pseudouridine synthase activity
AKO66_18930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AKO66_18935	COG1122	ATPase activity
AKO66_18940	COG1122	ATPase activity
AKO66_18945	COG0203	ribosomal protein L17
AKO66_18950	COG0202	RNA polymerase activity
AKO66_18955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AKO66_18960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AKO66_18965	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AKO66_18970	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AKO66_18975	COG0024	Methionine aminopeptidase
AKO66_18980	COG0563	adenylate kinase activity
AKO66_18985	COG0201	protein transport
AKO66_18990	COG0200	Binds to the 23S rRNA
AKO66_18995	COG1841	ribosomal large subunit assembly
AKO66_19000	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AKO66_19005	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AKO66_19010	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AKO66_19015	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AKO66_19020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AKO66_19025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AKO66_19030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AKO66_19035	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AKO66_19040	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AKO66_19045	COG0255	Belongs to the universal ribosomal protein uL29 family
AKO66_19050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AKO66_19055	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AKO66_19060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AKO66_19065	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AKO66_19070	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AKO66_19075	COG0089	rRNA binding
AKO66_19080	COG0088	Forms part of the polypeptide exit tunnel
AKO66_19085	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AKO66_19090	COG0051	transcription antitermination factor activity, RNA binding
AKO66_19095	COG0596	Alpha beta hydrolase
AKO66_19100	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AKO66_19105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AKO66_19110	COG0049	tRNA binding
AKO66_19115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AKO66_19120	COG1358	cellular component organization or biogenesis
AKO66_19125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AKO66_19130	COG0085	RNA polymerase activity
AKO66_19135	COG2813	Specifically methylates the guanine in position
AKO66_19140	COG0222	ribosome binding
AKO66_19145	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AKO66_19150	COG0081	regulation of translation
AKO66_19155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AKO66_19160	COG0250	Participates in transcription elongation, termination and antitermination
AKO66_19165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AKO66_19170	COG1595	DNA-templated transcription, initiation
AKO66_19175	COG3688	RNA-binding protein containing a PIN domain
AKO66_19180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AKO66_19185	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
AKO66_19190	COG0215	cysteine-tRNA ligase activity
AKO66_19195	COG1045	serine acetyltransferase
AKO66_19200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AKO66_19205	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AKO66_19210	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AKO66_19215	COG4956	integral membrane protein (PIN domain superfamily)
AKO66_19220	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
AKO66_19225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AKO66_19230	COG0542	response to heat
AKO66_19235	COG3869	Catalyzes the specific phosphorylation of arginine residues in
AKO66_19240	COG3880	PFAM UvrB UvrC protein
AKO66_19245	COG4463	regulation of RNA biosynthetic process