locus-tag class description BEN31_00105 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BEN31_00110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BEN31_00115 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BEN31_00135 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) BEN31_00170 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the BEN31_00315 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BEN31_00345 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BEN31_00380 ENOG4108MES Periplasmic binding protein BEN31_00390 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BEN31_00395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BEN31_00410 ENOG4108S9F abc transporter, atp-binding protein BEN31_00420 ENOG4108ZJ4 polysaccharide deacetylase BEN31_00425 ENOG4105DQ5 transport system permease protein BEN31_00430 ENOG4105EHG Permease protein BEN31_00435 ENOG4108V5C ABC transporter BEN31_00450 ENOG4105HTX biosynthesis protein BEN31_00455 ENOG4108QV3 biosynthesis protein BEN31_00465 ENOG4108PQP glycosyl transferase group 1 BEN31_00470 ENOG4105K64 Glycosyl transferase, family 2 BEN31_00475 ENOG4108KMV Glycosyl transferase (Group 1 BEN31_00480 ENOG41068W6 Capsular polysaccharide biosynthesis protein BEN31_00485 ENOG4107QRS glycosyltransferase group 2 family protein BEN31_00500 ENOG4105D3Q Sugar transferase BEN31_00505 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BEN31_00510 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BEN31_00515 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BEN31_00520 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BEN31_00525 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BEN31_00530 ENOG4105C3U ABC transporter BEN31_00535 ENOG4108JQ7 (ABC) transporter BEN31_00540 ENOG4107R73 Mate efflux family protein BEN31_00550 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_00555 ENOG4105JXH GntR family transcriptional regulator BEN31_00560 ENOG4108JUB Transcriptional regulator BEN31_00565 ENOG4105C8Y Acetylornithine aminotransferase BEN31_00580 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BEN31_00585 ENOG4105BZA Phosphoglycerate kinase BEN31_00590 ENOG4105CP7 Triose-phosphate isomerase BEN31_00600 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BEN31_00610 ENOG4105CJ1 ABC, transporter BEN31_00630 ENOG4108W0I acetyltransferase BEN31_00640 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BEN31_00645 ENOG4107HG4 Transcriptional regulator BEN31_00650 ENOG4108IJ8 ABC transporter BEN31_00655 ENOG4105E90 ABC transporter BEN31_00660 ENOG4108HQR Glycine betaine BEN31_00665 ENOG4105R40 Glycine betaine carnitine choline BEN31_00670 ENOG4105KVH Transcriptional regulator BEN31_00695 ENOG4105XZU Preprotein translocase, subunit SecG BEN31_00705 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BEN31_00710 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BEN31_00730 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_00795 ENOG410682Q Phage transcriptional regulator, ArpU BEN31_00835 ENOG4105CAR Terminase, large subunit BEN31_00915 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase BEN31_00925 ENOG41068G1 BEN31_00945 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BEN31_00975 ENOG4108X7A Terpene synthase metal-binding domain-containing protein BEN31_00985 ENOG4105BZU Histidine kinase BEN31_00995 ENOG4105VPX protein, conserved in bacteria BEN31_01000 ENOG410681U heavy metal transport detoxification protein BEN31_01005 ENOG4105C59 p-type ATPase BEN31_01015 ENOG4108IJ0 Aspartate ammonia-lyase BEN31_01030 ENOG4105W1N transcriptional regulator BEN31_01035 ENOG4105IIP Membrane BEN31_01040 ENOG4105DSE periplasmic solute binding protein BEN31_01045 ENOG4105CC5 ABC transporter BEN31_01050 ENOG4105DIK (ABC) transporter BEN31_01055 ENOG4105C59 p-type ATPase BEN31_01060 ENOG4107ZQN disulfide bond BEN31_01070 ENOG4105EN6 Membrane BEN31_01080 ENOG4107SUZ Sodium/hydrogen exchanger family BEN31_01085 ENOG4105EVU fructokinase BEN31_01095 ENOG4105E0C molybdate abc transporter BEN31_01100 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BEN31_01105 ENOG4107QZ2 Sulfatase BEN31_01110 ENOG4107K5X Membrane-bound metal-dependent hydrolase BEN31_01125 ENOG4105D5Q Arginine ornithine antiporter BEN31_01135 ENOG4105DQ5 transport system permease protein BEN31_01140 ENOG4105EHG Permease protein BEN31_01145 ENOG4105E0A ABC, transporter BEN31_01150 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BEN31_01160 ENOG4105D2H Uronic isomerase BEN31_01165 ENOG4107KJX Transcriptional regulator BEN31_01170 ENOG4107QZW Altronate oxidoreductase BEN31_01175 ENOG4105CTX dehydratase BEN31_01185 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BEN31_01190 ENOG4105EHG Permease protein BEN31_01195 ENOG4105E0A ABC, transporter BEN31_01200 ENOG4108WBT adenosyltransferase BEN31_01210 ENOG41087YS Phage shock protein A BEN31_01225 ENOG4105ENE Histidine kinase BEN31_01230 ENOG4105WH1 Two component transcriptional regulator luxr family BEN31_01255 ENOG4105C9Q fumarate hydratase class II BEN31_01260 ENOG41067SE Tetr family transcriptional regulator BEN31_01265 ENOG4105F3H Histidine kinase BEN31_01275 ENOG4105C0H protease BEN31_01280 ENOG4105E1F short-chain dehydrogenase reductase BEN31_01290 ENOG4105E0A ABC, transporter BEN31_01315 ENOG4105CHU acetyl-coa acetyltransferase BEN31_01320 ENOG4105C1G acyl-Coa dehydrogenase BEN31_01325 ENOG41080E8 Transcriptional regulator, Spx MgsR family BEN31_01330 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BEN31_01355 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BEN31_01360 ENOG4108UMI ABC transporter, permease BEN31_01365 ENOG4105D01 (LipO)protein BEN31_01375 ENOG4105C3K feS assembly ATPase SufC BEN31_01380 ENOG4105JRK feS assembly protein SufD BEN31_01385 ENOG4105C9B Cysteine desulfurase BEN31_01390 ENOG4108UNV SUF system FeS assembly protein, NifU family BEN31_01395 ENOG4105DIW FeS assembly protein SUFB BEN31_01400 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BEN31_01410 ENOG4105DHF Membrane BEN31_01415 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BEN31_01420 ENOG4108SWU Histidine kinase BEN31_01430 ENOG4108MES Periplasmic binding protein BEN31_01435 ENOG4105DQ5 transport system permease protein BEN31_01440 ENOG4108IHU transport system permease protein BEN31_01450 ENOG4108K8S endonuclease I BEN31_01455 ENOG4105C5R Aminotransferase BEN31_01465 ENOG4105F0F Oxalate decarboxylase BEN31_01470 ENOG4105G9B Transcriptional regulator BEN31_01475 ENOG4105I3N Conserved Protein BEN31_01480 ENOG4107R8B 5'-nucleotidase BEN31_01485 ENOG4105KZD Domain of unknown function (DUF1805) BEN31_01490 ENOG4108YTE sporulation protein YunB BEN31_01495 ENOG4105FAA peptidase M23 BEN31_01505 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BEN31_01510 ENOG4105MMD transcriptional regulator BEN31_01520 ENOG4105D4U had-superfamily hydrolase, subfamily iia BEN31_01525 ENOG4108W5N phosphatidylglycerophosphatase a BEN31_01535 ENOG4105C5I Dehydrogenase BEN31_01540 ENOG4105D6E homoserine dehydrogenase BEN31_01545 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BEN31_01555 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BEN31_01560 ENOG41083MR nifu domain-containing protein BEN31_01580 ENOG4105ZKE UPF0349 protein BEN31_01585 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BEN31_01590 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BEN31_01600 ENOG4107TXC Transcriptional regulator BEN31_01610 ENOG4105CAY ferredoxin--nadp reductase BEN31_01615 ENOG4105CEP NADH dehydrogenase BEN31_01625 ENOG41069ER domain protein BEN31_01635 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BEN31_01645 ENOG4108N23 SpoOM-related protein BEN31_01655 ENOG4105DCF alanine dehydrogenase BEN31_01660 ENOG4108K8K Transcriptional regulator BEN31_01695 ENOG410904N short-chain dehydrogenase reductase BEN31_01715 ENOG4105C02 permease BEN31_01745 ENOG4105DAP Nicotinate phosphoribosyltransferase BEN31_01750 ENOG4105D58 Diguanylate phosphodiesterase BEN31_01770 ENOG4105BZU Histidine kinase BEN31_01780 ENOG4105KA0 thioesterase Superfamily protein BEN31_01785 ENOG4105KJM monovalent cation h antiporter subunit g BEN31_01795 ENOG4105SC1 monovalent cation H antiporter subunit E BEN31_01800 ENOG4108JPZ Monovalent cation H antiporter subunit D BEN31_01805 ENOG4108ZE9 Monovalent cation H antiporter subunit C BEN31_01810 ENOG4105HC0 Na H antiporter BEN31_01815 ENOG4105D65 subunit l BEN31_01835 ENOG4105UIB (ABC) transporter BEN31_01840 ENOG4108JQ9 ABC transporter BEN31_01845 ENOG4105DIH basic membrane BEN31_01850 ENOG4108MRH transcriptional regulatory protein BEN31_01865 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BEN31_01870 ENOG4105BZ4 penicillin-binding protein BEN31_01885 ENOG4105Y38 Kinase-associated protein B BEN31_01895 ENOG4108HGU Histidine kinase BEN31_01900 ENOG4105C87 Aminotransferase class I and II BEN31_01910 ENOG4108MUZ hydrolase BEN31_01915 ENOG4108ZB6 transcriptional regulator AsnC family BEN31_01920 ENOG4105CHM Aminotransferase BEN31_01930 ENOG4105WG9 Conserved Protein BEN31_01935 ENOG4107QW4 alcohol dehydrogenase BEN31_01945 ENOG4107QYV phosphohexose isomerase BEN31_01960 ENOG4107PBV potassium channel BEN31_01975 ENOG4105C37 (CBS) domain BEN31_01980 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BEN31_01985 ENOG4105EA8 2-Nitropropane dioxygenase BEN31_02000 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_02005 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_02010 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_02015 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_02020 ENOG4108Z0Z intracellular protease Pfpi family BEN31_02025 ENOG4105EE0 oxidoreductase BEN31_02045 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BEN31_02055 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BEN31_02080 ENOG4105QBX endodeoxyribonuclease RusA BEN31_02100 ENOG4105IG6 Phage terminase, large subunit BEN31_02105 ENOG4108MDF Phage Portal Protein BEN31_02130 ENOG41060SN BEN31_02145 ENOG4105PQS phage protein BEN31_02150 ENOG4105FR7 XkdM protein, phage-like element PBSX BEN31_02155 ENOG4105MTC XkdN-like protein BEN31_02160 ENOG4108FKH Transglycosylase SLT domain BEN31_02160 ENOG4108FKH Transglycosylase SLT domain BEN31_02165 ENOG4108WZM domain protein BEN31_02170 ENOG4105X7F BEN31_02180 ENOG4105MFU Protein of unknown function (DUF2634) BEN31_02185 ENOG41066EA baseplate J family protein BEN31_02190 ENOG410906S phage-like element pbsx protein xkdt BEN31_02225 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BEN31_02240 ENOG4105TRT Transcriptional regulator BEN31_02245 ENOG4105C26 Dehydrogenase BEN31_02250 ENOG4108JB8 alcohol dehydrogenase BEN31_02255 ENOG4106DF1 BEN31_02265 ENOG4105DZ6 Band 7 protein BEN31_02270 ENOG4105CNI cell division protein FtsW BEN31_02275 ENOG4105CNI cell division protein FtsW BEN31_02285 ENOG4105VRR gCN5-related N-acetyltransferase BEN31_02290 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BEN31_02415 ENOG4108606 TspO/MBR family BEN31_02425 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BEN31_02430 ENOG4105E4F Isochorismate synthase BEN31_02435 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BEN31_02440 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BEN31_02445 ENOG4108IPT Naphthoate synthase BEN31_02455 ENOG4105DTQ mandelate racemase muconate lactonizing BEN31_02490 ENOG4105DSE periplasmic solute binding protein BEN31_02495 ENOG4108V2W Carbonate dehydratase BEN31_02500 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BEN31_02505 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BEN31_02520 ENOG4108RMU ferritin dps family protein BEN31_02545 ENOG4106FN3 tellurium resistance protein BEN31_02555 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BEN31_02565 ENOG4105D2X ABC transporter substrate-binding protein BEN31_02595 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BEN31_02600 ENOG4105CAQ asparagine synthetase BEN31_02605 ENOG4108Z0R Transferase BEN31_02610 ENOG4105E8V Alpha Beta Hydrolase Fold protein BEN31_02625 ENOG4105N5T Radical SAM Protein BEN31_02640 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BEN31_02645 ENOG4105DVE abc transporter atp-binding protein BEN31_02655 ENOG4105C19 ABC transporter BEN31_02660 ENOG4107R34 abc transporter permease protein BEN31_02665 ENOG4106UBQ BEN31_02670 ENOG4105BZU Histidine kinase BEN31_02680 ENOG4105C8T Leucyl-tRNA synthetase BEN31_02685 ENOG4105NTD Inherit from COG: Hydrolase BEN31_02695 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BEN31_02705 ENOG4105CV8 reductase BEN31_02710 ENOG4105F27 Major Facilitator BEN31_02715 ENOG4105KVH Transcriptional regulator BEN31_02720 ENOG41075H3 AraC family transcriptional regulator BEN31_02730 ENOG4105F5H Glycosyl Hydrolase Family 88 BEN31_02740 ENOG4105DDC Oxidoreductase domain protein BEN31_02745 ENOG4105MU9 integral membrane protein BEN31_02750 ENOG41085GJ domain protein BEN31_02765 ENOG4105C94 Transporter BEN31_02775 ENOG4105CBX hi0933 family BEN31_02790 ENOG4105YW5 deoR family transcriptional regulator BEN31_02795 ENOG4105C7N Xanthine uracil vitamin C permease BEN31_02800 ENOG4107QSE Dipeptidase BEN31_02805 ENOG4107UIE peptidase BEN31_02810 ENOG4105C6T cysteine synthase BEN31_02815 ENOG4107F58 2'-5' rna ligase BEN31_02830 ENOG4108V15 phosphotransferase enzyme family BEN31_02840 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BEN31_02845 ENOG4105C8F Beta-lactamase domain protein BEN31_02850 ENOG4105C6K Malic enzyme BEN31_02865 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BEN31_02880 ENOG4108NKM UPF0354 protein BEN31_02885 ENOG4108VDD TRNA binding domain protein BEN31_02895 ENOG4105DFU Cell wall formation (By similarity) BEN31_02915 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BEN31_02920 ENOG4105ETE Transcriptional regulator (LacI family BEN31_02925 ENOG4105DGU Histone deacetylase BEN31_02930 ENOG4105W87 Cbs domain BEN31_02935 ENOG4105F1V Acetoin utilization protein BEN31_02945 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BEN31_02950 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BEN31_02975 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BEN31_02985 ENOG4105U5Y Transcriptional regulator BEN31_03015 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BEN31_03025 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BEN31_03030 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BEN31_03040 ENOG4108X0B nad(p)h dehydrogenase (quinone) BEN31_03045 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BEN31_03055 ENOG4105C19 ABC transporter BEN31_03065 ENOG4105CNI cell division protein FtsW BEN31_03070 ENOG4105EWM Histidine kinase BEN31_03085 ENOG4108S01 response regulator BEN31_03090 ENOG4108ZGX Histidine kinase BEN31_03095 ENOG4105ECK Fatty Acid Desaturase BEN31_03100 ENOG4105C1J atp-dependent rna helicase BEN31_03105 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BEN31_03110 ENOG4105D07 Signal peptide peptidase, SppA BEN31_03115 ENOG4105VK3 rdd domain containing protein BEN31_03125 ENOG4105KBJ sporulation protein ytfj BEN31_03130 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BEN31_03140 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BEN31_03145 ENOG4105EPU Molybdenum cofactor synthesis domain protein BEN31_03150 ENOG4105CDH Citrulline--aspartate ligase BEN31_03155 ENOG4105CH7 arginosuccinase BEN31_03165 ENOG4105E8R UPF0173 metal-dependent hydrolase BEN31_03180 ENOG4105SFS phosphoesterase RecJ domain protein BEN31_03185 ENOG4106EVM BEN31_03195 ENOG4105VV2 BEN31_03200 ENOG4105C0B DNA polymerase III (alpha subunit) BEN31_03205 ENOG4105C6K Malic enzyme BEN31_03210 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BEN31_03220 ENOG4105CTQ phosphohexokinase BEN31_03225 ENOG4105CA9 Pyruvate kinase BEN31_03230 ENOG4105FS0 cytoplasmic membrane protein BEN31_03235 ENOG4108REF Sporulation integral membrane protein ytvi BEN31_03240 ENOG4107CWS Protein of unknown function (DUF441) BEN31_03245 ENOG4105BZN citrate synthase BEN31_03250 ENOG4108HMX isocitrate dehydrogenase (NADP) BEN31_03255 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BEN31_03260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BEN31_03265 ENOG4105BZU Histidine kinase BEN31_03270 ENOG4105C2M dna polymerase I BEN31_03275 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BEN31_03285 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BEN31_03290 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BEN31_03295 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BEN31_03305 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BEN31_03325 ENOG4108TDW sporulation protein YtxC BEN31_03330 ENOG4105C22 threonyL-tRNA synthetase BEN31_03335 ENOG4107SDU Methyl-accepting chemotaxis BEN31_03340 ENOG4105U0R haloacid dehalogenase-like hydrolase BEN31_03345 ENOG4108HRK Histidine kinase BEN31_03350 ENOG4105DY9 regulatoR BEN31_03360 ENOG41067MG lrgb family BEN31_03365 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BEN31_03370 ENOG4105VJV 50s ribosomal protein L35 BEN31_03375 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BEN31_03380 ENOG410696E Membrane BEN31_03390 ENOG4105CN9 Peptidase m42 family protein BEN31_03400 ENOG41067MF small acid-soluble spore protein BEN31_03405 ENOG4108RWN rrna methyltransferase BEN31_03410 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BEN31_03415 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BEN31_03420 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BEN31_03425 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BEN31_03435 ENOG4105DCG PHP domain protein BEN31_03440 ENOG4105C98 muts2 protein BEN31_03455 ENOG4105CEY Amp-dependent synthetase and ligase BEN31_03460 ENOG4107Z3H Transcriptional regulator, TetR family BEN31_03465 ENOG41060WC Enoyl-CoA hydratase BEN31_03470 ENOG4105BZJ Electron transfer flavoprotein BEN31_03475 ENOG4105C10 Electron transfer flavoprotein BEN31_03480 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BEN31_03485 ENOG4105K63 Thioredoxin BEN31_03490 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BEN31_03495 ENOG4105CFH Aspartokinase BEN31_03505 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BEN31_03515 ENOG4105E33 succinate dehydrogenase BEN31_03525 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BEN31_03530 ENOG4105C7F AcnD-accessory protein PrpF BEN31_03535 ENOG4108KAM Transcriptional regulator BEN31_03545 ENOG4105PFC Transcriptional regulator BEN31_03550 ENOG41067TZ transcriptional regulator, MarR family BEN31_03555 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BEN31_03560 ENOG4108XJQ germination protein BEN31_03565 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BEN31_03570 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BEN31_03575 ENOG4105M59 Phosphodiesterase, mj0936 family BEN31_03600 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BEN31_03605 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BEN31_03615 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BEN31_03625 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BEN31_03630 ENOG4105CM2 brancheD-chain amino acid aminotransferase BEN31_03635 ENOG4105C7K acetolactate synthase BEN31_03640 ENOG4108ZP8 Acetolactate synthase small subunit BEN31_03645 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BEN31_03650 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BEN31_03655 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BEN31_03660 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BEN31_03665 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BEN31_03675 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BEN31_03680 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BEN31_03685 ENOG4108IUQ atp-dependent protease BEN31_03690 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BEN31_03695 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BEN31_03705 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BEN31_03715 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BEN31_03725 ENOG4105D52 delta-aminolevulinic acid dehydratase BEN31_03730 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BEN31_03735 ENOG41068KH stage VI sporulation protein D BEN31_03740 ENOG4106AR7 Spore coat protein BEN31_03750 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BEN31_03755 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BEN31_03760 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BEN31_03770 ENOG4108Z03 MAF-like protein BEN31_03775 ENOG4105W5Q DNA repair protein (RadC BEN31_03780 ENOG4105DFF Rod shape-determining protein mreb BEN31_03785 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BEN31_03790 ENOG4105YHC Rod shape-determining protein MreD BEN31_03795 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BEN31_03800 ENOG4107QMS site-determining protein BEN31_03815 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BEN31_03820 ENOG4105X36 (ribosomal) protein BEN31_03825 ENOG4105K46 50S ribosomal protein l27 BEN31_03835 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BEN31_03845 ENOG4105CQC Prephenate dehydratase BEN31_03860 ENOG4108IYU L-aspartate oxidase BEN31_03865 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BEN31_03870 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BEN31_03875 ENOG4106678 morphogenetic protein associated with SpoVID BEN31_03875 ENOG4106678 morphogenetic protein associated with SpoVID BEN31_03885 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BEN31_03905 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BEN31_03910 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BEN31_03915 ENOG41061AI Protein of unknown function (DUF2905) BEN31_03920 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BEN31_03925 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BEN31_03930 ENOG4105VIE preprotein translocase, subunit YajC BEN31_03935 ENOG4105NAP BEN31_03940 ENOG4108QG2 Membrane BEN31_03945 ENOG4105CKP Polysaccharide Biosynthesis Protein BEN31_03955 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BEN31_03960 ENOG4105NCW Trka-c domain protein BEN31_03965 ENOG41067VP Protein of unknown function (DUF1049) BEN31_03970 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BEN31_03975 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BEN31_03980 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BEN31_03985 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BEN31_03990 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BEN31_03995 ENOG4105CUT histidyl-tRNA synthetase BEN31_04000 ENOG4105C9M aspartyl-trna synthetase BEN31_04010 ENOG4105CUZ uba thif-type nad fad binding protein BEN31_04015 ENOG4105D1H recombination factor protein RarA BEN31_04025 ENOG4105C3J Cysteine desulfurase BEN31_04030 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BEN31_04040 ENOG4105C7H Helicase, RecD TraA family BEN31_04050 ENOG41060CR BEN31_04060 ENOG4105DRP amino acid AbC transporter BEN31_04065 ENOG4105EAD ABC transporter BEN31_04070 ENOG4105CT1 (ABC) transporter BEN31_04075 ENOG4105CDA abc transporter atp-binding protein BEN31_04080 ENOG4105C02 permease BEN31_04090 ENOG4105VBH UPF0297 protein BEN31_04095 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BEN31_04100 ENOG4105VPH UPF0473 protein BEN31_04105 ENOG4107ZYJ bioY protein BEN31_04110 ENOG4107F3J Amp-dependent synthetase and ligase BEN31_04120 ENOG4105HHA aminodeoxychorismate lyase BEN31_04125 ENOG4108VQJ O-methyltransferase BEN31_04130 ENOG4105XYU peptidase (U32 family) BEN31_04135 ENOG4105CFP Peptidase U32 BEN31_04140 ENOG4107S03 uridine kinase BEN31_04145 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BEN31_04150 ENOG4107XRG penicillin-binding protein BEN31_04165 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BEN31_04170 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BEN31_04180 ENOG4105C28 cystathionine BEN31_04200 ENOG4105E2A Dehydrogenase BEN31_04205 ENOG41089UC methyltransferase, type 11 BEN31_04210 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BEN31_04225 ENOG4105WEF catalase BEN31_04230 ENOG4105E5Q amino acid AbC transporter BEN31_04250 ENOG4105FDT acyl-CoA dehydrogenase BEN31_04255 ENOG4108HWY Beta-lactamase BEN31_04285 ENOG4105KVH Transcriptional regulator BEN31_04290 ENOG4108VA3 3-hexulose-6-phosphate synthase BEN31_04295 ENOG41080HJ 6-phospho 3-hexuloisomerase BEN31_04305 ENOG4105CMD Transcriptional regulator, GntR family BEN31_04320 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BEN31_04325 ENOG4107QNK )-transporter BEN31_04340 ENOG4105CJ1 ABC, transporter BEN31_04375 ENOG4108ZJ4 polysaccharide deacetylase BEN31_04390 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BEN31_04400 ENOG4105M4P Tetr family transcriptional regulator BEN31_04405 ENOG4107TTQ Alpha beta hydrolase fold BEN31_04410 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BEN31_04415 ENOG4108IXY short-chain dehydrogenase reductase BEN31_04420 ENOG4107GJV short-chain dehydrogenase reductase BEN31_04425 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BEN31_04430 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_04440 ENOG4108ZJ4 polysaccharide deacetylase BEN31_04455 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BEN31_04460 ENOG4105CQW ribosome biogenesis GTPase YqeH BEN31_04465 ENOG4105E2X shikimate dehydrogenase BEN31_04470 ENOG410812S Rna-binding protein BEN31_04475 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BEN31_04480 ENOG4108WF2 Metal Dependent Phosphohydrolase BEN31_04490 ENOG4108D32 Methyltransferase BEN31_04500 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BEN31_04505 ENOG4108UK2 deaminase BEN31_04510 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BEN31_04520 ENOG4105TQK DNA polymerase iii, delta' subunit BEN31_04535 ENOG4108ZRV stage ii sporulation protein p BEN31_04545 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BEN31_04550 ENOG4105CSA Coproporphyrinogen iii oxidase BEN31_04555 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BEN31_04560 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BEN31_04570 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BEN31_04575 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BEN31_04580 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BEN31_04585 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BEN31_04600 ENOG4105KTH gatB Yqey BEN31_04605 ENOG4105F7J membrane-bound serine protease BEN31_04610 ENOG4105DI5 UPF0365 protein BEN31_04620 ENOG41068P3 sporulation protein YqfC BEN31_04625 ENOG4105EI1 sporulation protein yqfd BEN31_04630 ENOG4105C9A Phoh family BEN31_04635 ENOG4105CTJ Metal Dependent Phosphohydrolase BEN31_04640 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BEN31_04645 ENOG4107YR5 Diacylglycerol kinase BEN31_04650 ENOG4105KG3 cytidine deaminase BEN31_04655 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BEN31_04665 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BEN31_04670 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BEN31_04675 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BEN31_04685 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BEN31_04690 ENOG4108UPT UPF0178 protein BEN31_04695 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BEN31_04700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_04715 ENOG4105EGD dinuclear metal center protein, YbgI family BEN31_04720 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BEN31_04735 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BEN31_04740 ENOG41069ZM Protein of unknown function (DUF2624) BEN31_04745 ENOG4108JYZ YitT family BEN31_04750 ENOG4105FDK ABC transporter BEN31_04755 ENOG4105FAV ABC, transporter BEN31_04760 ENOG4105N80 Ferric uptake regulator, Fur family BEN31_04765 ENOG41066F8 ROK family BEN31_04770 ENOG4108U5J '-nucleotidase BEN31_04775 ENOG41063Y9 BEN31_04780 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BEN31_04790 ENOG4105D9U N-acetyltransferase BEN31_04800 ENOG4105SXS Protein of unknown function (DUF456) BEN31_04805 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BEN31_04815 ENOG4107RF6 penicillin-binding protein BEN31_04820 ENOG4105CVA phosphate BEN31_04825 ENOG4105C8U phosphate abc transporter BEN31_04830 ENOG4105E2Z phosphate ABC transporter (Permease BEN31_04835 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BEN31_04840 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BEN31_04845 ENOG41068DG YceG-like family BEN31_04855 ENOG4105WDJ 50S ribosomal protein L33 BEN31_04860 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BEN31_04865 ENOG4107ZXI Rhomboid family BEN31_04880 ENOG4105E0M Sulfatase BEN31_04905 ENOG4105C5X domain protein BEN31_04945 ENOG4106855 Competence protein BEN31_04985 ENOG4105VFR signal peptidase BEN31_05005 ENOG4105C0D helicase BEN31_05010 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BEN31_05020 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BEN31_05025 ENOG4105WZW rhodanese family BEN31_05030 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BEN31_05035 ENOG4105KST dependent repressor BEN31_05050 ENOG4105CBJ Metal-dependent enzyme BEN31_05060 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BEN31_05065 ENOG4105DC7 peptidase M24 BEN31_05070 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BEN31_05080 ENOG4105CD2 stage iii sporulation protein aa BEN31_05085 ENOG4105KR5 Stage iii sporulation protein BEN31_05090 ENOG4108CQH stage III sporulation protein AC BEN31_05095 ENOG4105KQ4 Stage iii sporulation protein ad BEN31_05105 ENOG410644B Stage III sporulation protein af BEN31_05125 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BEN31_05130 ENOG4108ZSR alkaline shock protein BEN31_05135 ENOG4105M7K Involved in the transcription termination process (By similarity) BEN31_05140 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BEN31_05145 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BEN31_05150 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BEN31_05155 ENOG4105CTB Polyprenyl synthetase BEN31_05160 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BEN31_05165 ENOG4105DX0 Hemolysin A BEN31_05170 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BEN31_05175 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BEN31_05180 ENOG4105S1Z Stage IV sporulation protein B BEN31_05185 ENOG4107QQR Sporulation BEN31_05200 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BEN31_05205 ENOG4106CCJ Protein of unknown function (DUF2627) BEN31_05210 ENOG4108JUB Transcriptional regulator BEN31_05220 ENOG4107RDP Dehydrogenase BEN31_05225 ENOG4105CKM Branched-chain carboxylic acid kinase BEN31_05240 ENOG4105CPP Dehydrogenase, E1 component BEN31_05245 ENOG4105C7S Dehydrogenase BEN31_05255 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BEN31_05260 ENOG4108Y6J UPF0403 protein BEN31_05265 ENOG4108HW3 (ABC) transporter BEN31_05270 ENOG4105E5Q amino acid AbC transporter BEN31_05275 ENOG4105CDA abc transporter atp-binding protein BEN31_05280 ENOG4108QEG Membrane BEN31_05285 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BEN31_05290 ENOG4108ZVT methylmalonyl-coA epimerase BEN31_05295 ENOG4108HNZ carboxyl transferase BEN31_05300 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BEN31_05310 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BEN31_05320 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BEN31_05325 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BEN31_05330 ENOG4105CSC Glucose uptake protein BEN31_05335 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BEN31_05340 ENOG4105VZJ PTS System BEN31_05345 ENOG4105VCP PTS System BEN31_05350 ENOG4105CK1 PTS System BEN31_05355 ENOG4105CS2 ec 3.2.1.21 BEN31_05360 ENOG4108TZY GntR Family Transcriptional Regulator BEN31_05365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BEN31_05370 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BEN31_05375 ENOG4105XT2 Transcriptional regulator BEN31_05385 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BEN31_05400 ENOG4105II7 pyrroline-5-carboxylate reductase BEN31_05405 ENOG41069FQ Metallo-beta-lactamase superfamily BEN31_05410 ENOG4108IXY short-chain dehydrogenase reductase BEN31_05415 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BEN31_05425 ENOG4105E5W Transporter BEN31_05435 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BEN31_05445 ENOG4108XET gCN5-related N-acetyltransferase BEN31_05450 ENOG4105RHY Pfam:UPF0157 BEN31_05455 ENOG4108YQE rare lipoprotein a BEN31_05460 ENOG4106HZJ BEN31_05490 ENOG4105CPC Aldo Keto reductase BEN31_05495 ENOG4108YZ4 nudix hydrolase BEN31_05520 ENOG4105MZ9 stage II sporulation protein m BEN31_05525 ENOG4105I3K Ferric uptake regulator, Fur family BEN31_05535 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BEN31_05540 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BEN31_05545 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BEN31_05550 ENOG4105DZ1 carboxypeptidase BEN31_05555 ENOG41082AN stage II sporulation protein BEN31_05560 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BEN31_05565 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_05580 ENOG41090VF Stage v sporulation protein ac BEN31_05585 ENOG4105CZ3 stage V sporulation protein ad BEN31_05595 ENOG4105G6R Stage v sporulation protein ae BEN31_05605 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BEN31_05610 ENOG4105PTM secreted protein BEN31_05615 ENOG4107ZE5 PPIases accelerate the folding of proteins BEN31_05640 ENOG4108R6K riboflavin synthase, subunit alpha BEN31_05650 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BEN31_05665 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BEN31_05670 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BEN31_05680 ENOG4105DZ1 carboxypeptidase BEN31_05685 ENOG4108JIC nucleoside recognition domain protein BEN31_05695 ENOG4105FE9 pseudouridine synthase BEN31_05700 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BEN31_05705 ENOG4107TWT Cytochrome c biogenesis protein BEN31_05710 ENOG4105CRE cytochrome C BEN31_05715 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BEN31_05720 ENOG4105BZU Histidine kinase BEN31_05735 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BEN31_05740 ENOG4108JQ1 Dehydrogenase BEN31_05745 ENOG4108SAX Membrane BEN31_05755 ENOG4105T7X BEN31_05760 ENOG4105C9U ATP-dependent DNA helicase RecQ BEN31_05765 ENOG4105I7S Abortive infection protein BEN31_05780 ENOG4107RGJ metallophosphoesterase BEN31_05795 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BEN31_05800 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BEN31_05810 ENOG4105MSI germination protein ypeb BEN31_05825 ENOG4105CAT Cytidine monophosphate kinase BEN31_05830 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BEN31_05850 ENOG4105S2F BEN31_05855 ENOG41065D1 BEN31_05860 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BEN31_05865 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BEN31_05880 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BEN31_05885 ENOG4105K70 DNA-binding protein BEN31_05890 ENOG4105EUJ GTP cyclohydrolase i BEN31_05900 ENOG4105XXQ heptaprenyl diphosphate synthase component I BEN31_05905 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BEN31_05910 ENOG4105EAH synthase BEN31_05915 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BEN31_05920 ENOG4105BZU Histidine kinase BEN31_05925 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BEN31_05930 ENOG4105D49 3-dehydroquinate synthase BEN31_05935 ENOG4105KHN chorismate mutase BEN31_05945 ENOG4108I0Q anthranilate phosphoribosyltransferase BEN31_05950 ENOG4105DK0 Indole-3-glycerol phosphate synthase BEN31_05960 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BEN31_05965 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BEN31_05970 ENOG4105CIH Imidazole acetol-phosphate transaminase BEN31_05980 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BEN31_05985 ENOG41068YB TPR repeat-containing protein BEN31_05990 ENOG4108SXZ UPF0302 protein BEN31_06005 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BEN31_06025 ENOG4108JYZ YitT family BEN31_06030 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BEN31_06035 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BEN31_06040 ENOG4108Z5K methylglyoxal synthase BEN31_06045 ENOG4105FJR Lmbe family BEN31_06050 ENOG4105CPK Glycosyl transferase (Group 1 BEN31_06055 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BEN31_06065 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BEN31_06070 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BEN31_06075 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BEN31_06080 ENOG4105DVT helicase BEN31_06085 ENOG4105YAC BEN31_06105 ENOG4105CSM endonuclease III BEN31_06115 ENOG4105BZ4 penicillin-binding protein BEN31_06120 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BEN31_06160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BEN31_06165 ENOG4108I5C dEAD DEAH box helicase BEN31_06170 ENOG4107X2U Inherit from COG: Exonuclease-like protein BEN31_06175 ENOG4108UKS UPF0398 protein BEN31_06180 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BEN31_06190 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BEN31_06200 ENOG4105DVT helicase BEN31_06205 ENOG4105CTD carboxy-peptidase BEN31_06215 ENOG4105C2W permease BEN31_06220 ENOG41065KQ synthase BEN31_06230 ENOG410890F Dynamin family BEN31_06250 ENOG41081VK Ribonuclease BEN31_06285 ENOG4108QBV Monogalactosyldiacylglycerol synthase BEN31_06290 ENOG4105CVG Homoserine O-transsuccinylase BEN31_06295 ENOG4105CKU formyltetrahydrofolate synthetase BEN31_06300 ENOG4108V06 Glutathione peroxidase BEN31_06315 ENOG4105C01 Dihydroxy-acid dehydratase BEN31_06320 ENOG4108Y6J UPF0403 protein BEN31_06325 ENOG4107YX5 Pfam:DUF548 BEN31_06340 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BEN31_06345 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BEN31_06355 ENOG4108UT2 hemolysin iii BEN31_06365 ENOG4105C7B Threonine dehydratase BEN31_06380 ENOG4108KF3 Electron transport protein SCO1 SenC BEN31_06385 ENOG41090WU lipolytic protein G-D-S-L family BEN31_06390 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BEN31_06415 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BEN31_06420 ENOG4105E0X reductase BEN31_06425 ENOG4105C5E polysaccharide biosynthesis protein BEN31_06455 ENOG4108JUB Transcriptional regulator BEN31_06460 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BEN31_06470 ENOG4105VSD UPF0346 protein BEN31_06485 ENOG410841Q phosphoesterase PA-phosphatase related protein BEN31_06490 ENOG4106Z5R BEN31_06495 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BEN31_06500 ENOG4108VXD carboxy-peptidase BEN31_06520 ENOG4105E1V na solute symporter BEN31_06550 ENOG4105FR1 rard protein BEN31_06570 ENOG4107QMU Mate efflux family protein BEN31_06580 ENOG4105K4H Nlp p60 protein BEN31_06590 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BEN31_06595 ENOG4107T89 von Willebrand factor, type A BEN31_06600 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BEN31_06605 ENOG4105C7S Dehydrogenase BEN31_06610 ENOG4105C09 Bile acid BEN31_06615 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BEN31_06620 ENOG4105EWU Squalene--hopene cyclase BEN31_06625 ENOG4105C26 Dehydrogenase BEN31_06645 ENOG4105SCY DNAK suppressor BEN31_06655 ENOG4105C9U ATP-dependent DNA helicase RecQ BEN31_06660 ENOG41069ER domain protein BEN31_06670 ENOG4108SJC Membrane BEN31_06680 ENOG4105DXD 2-methylcitrate dehydratase BEN31_06685 ENOG4105CR4 methylisocitrate lyase BEN31_06695 ENOG4105CUB amino acid BEN31_06700 ENOG4105KTU Transcriptional regulator, arsr family BEN31_06710 ENOG4105D29 Helix-turn-helix type 11 domain protein BEN31_06740 ENOG4108Z7R Chaperone CsaA BEN31_06745 ENOG4105CT4 transporter BEN31_06755 ENOG4105E2R ROK family BEN31_06765 ENOG4105CMG Carbohydrate kinase BEN31_06775 ENOG4108J2R molybdopterin oxidoreductase BEN31_06790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BEN31_06795 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BEN31_06800 ENOG4108UYN gCN5-related N-acetyltransferase BEN31_06820 ENOG4105C5Q Transcriptional regulator BEN31_06825 ENOG4105CBC glutamate synthase BEN31_06830 ENOG4105BZ8 glutamate synthase BEN31_06845 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BEN31_06850 ENOG4108IFG nitrite reductase, (NAD(P)H) BEN31_06855 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BEN31_06860 ENOG4105H67 Protein of unknown function (DUF421) BEN31_06865 ENOG4105NBR Pectinesterase BEN31_06870 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BEN31_06875 ENOG4107QJQ Mate efflux family protein BEN31_06900 ENOG4105DEN Luciferase family BEN31_06910 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BEN31_06915 ENOG4107T5V SNARE associated Golgi BEN31_06940 ENOG4108B31 Spore germination protein BEN31_06950 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BEN31_06955 ENOG4105CQB FAD linked oxidase domain protein BEN31_06980 ENOG4105F32 YngK protein BEN31_06985 ENOG4105C1G acyl-Coa dehydrogenase BEN31_06990 ENOG4105CEY Amp-dependent synthetase and ligase BEN31_06995 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BEN31_07000 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BEN31_07005 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BEN31_07010 ENOG4105E39 Enoyl-CoA hydratase BEN31_07015 ENOG4107QX3 carboxylase BEN31_07020 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BEN31_07030 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BEN31_07040 ENOG4105C26 Dehydrogenase BEN31_07060 ENOG4107RZC phospholipase d BEN31_07065 ENOG4105HX0 Transcriptional regulator BEN31_07070 ENOG4105DE4 1-phosphofructokinase BEN31_07075 ENOG4105DM4 PTS System BEN31_07080 ENOG4105DM4 PTS System BEN31_07115 ENOG4106ETB IIa component BEN31_07130 ENOG4105UP7 3-epimerase BEN31_07145 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BEN31_07150 ENOG4105I1K ABC transporter BEN31_07165 ENOG4107SYN Glycosyl hydrolases family 43 BEN31_07175 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BEN31_07210 ENOG4105CZN Potassium uptake protein BEN31_07220 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) BEN31_07235 ENOG4105KME endoribonuclease L-psp BEN31_07240 ENOG4105C6T cysteine synthase BEN31_07245 ENOG41082YX Transcriptional regulator, arsr family BEN31_07250 ENOG4107R5R arsenical pump membrane protein BEN31_07255 ENOG4108UXE Protein tyrosine phosphatase BEN31_07275 ENOG4107V2S Transcriptional regulator BEN31_07285 ENOG4105KVH Transcriptional regulator BEN31_07305 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BEN31_07310 ENOG4106UW1 Major Facilitator superfamily BEN31_07325 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BEN31_07335 ENOG4105K4P CoA-binding domain protein BEN31_07340 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BEN31_07345 ENOG4105W8X HesB YadR YfhF-family protein BEN31_07350 ENOG4105MI2 BEN31_07375 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BEN31_07380 ENOG4108I0Z Aconitate hydratase BEN31_07410 ENOG4107QIV Cytochrome c biogenesis protein BEN31_07420 ENOG4105VXM UPF0154 protein BEN31_07430 ENOG4105CV1 Transketolase (EC 2.2.1.1) BEN31_07435 ENOG4105VPS UPF0291 protein BEN31_07440 ENOG4108SVB resolvase BEN31_07450 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BEN31_07465 ENOG4106SCS STAS domain BEN31_07470 ENOG4105WFK nuclease BEN31_07475 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases BEN31_07480 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BEN31_07485 ENOG41082JN Transcriptional regulator BEN31_07505 ENOG41080R8 Conserved Protein BEN31_07510 ENOG4107QR9 Iron-sulfur cluster binding protein BEN31_07515 ENOG4107R5T Cysteine-rich domain BEN31_07520 ENOG4105ECR NmrA family BEN31_07525 ENOG4108Z40 Transcriptional regulator BEN31_07535 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BEN31_07540 ENOG4105FDF Could be involved in DNA repair (By similarity) BEN31_07545 ENOG4105DQE DNA ligase BEN31_07550 ENOG4105XPP Protein of unknown function (DUF1275) BEN31_07560 ENOG410780I phosphoprotein phosphatase activity BEN31_07570 ENOG4108ZMX Domain of unknown function (DU1801) BEN31_07600 ENOG410780I phosphoprotein phosphatase activity BEN31_07605 ENOG4105C5F glutamine synthetase BEN31_07610 ENOG4105KV4 Transcriptional regulator BEN31_07615 ENOG4105CXI aluminum resistance protein BEN31_07620 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BEN31_07625 ENOG4106F1P AAA ATPase, central domain protein BEN31_07635 ENOG4105U6W MutT NUDIX family protein BEN31_07640 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BEN31_07645 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BEN31_07650 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BEN31_07670 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BEN31_07695 ENOG410814C multidrug resistance protein BEN31_07700 ENOG4108X3M OsmC Ohr family protein BEN31_07705 ENOG4105K7W phage-related replication protein BEN31_07710 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_07720 ENOG4105K7W phage-related replication protein BEN31_07725 ENOG4108VJ1 Transcriptional regulator (CarD family BEN31_07745 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BEN31_07750 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BEN31_07765 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BEN31_07770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BEN31_07775 ENOG4105CPQ Dehydrogenase BEN31_07785 ENOG4105MCT stage V sporulation protein S BEN31_07790 ENOG4105D48 metallophosphoesterase BEN31_07795 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BEN31_07800 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BEN31_07805 ENOG4105CEV competence damage-inducible protein BEN31_07810 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BEN31_07825 ENOG4105XZV Protein of unknown function (DUF3243) BEN31_07830 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BEN31_07835 ENOG4105EYF MMPL domain protein BEN31_07855 ENOG4105EYF MMPL domain protein BEN31_07865 ENOG4105FDP GntR family transcriptional regulator BEN31_07870 ENOG4105CNU cell division protein FtsK BEN31_07880 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BEN31_07890 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BEN31_07900 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BEN31_07905 ENOG4108S0H Dipicolinic acid synthetase, b subunit BEN31_07910 ENOG4105E35 Dipicolinate synthase subunit A BEN31_07925 ENOG4105C1V Peptidase, M16 BEN31_07935 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BEN31_07940 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BEN31_07945 ENOG4105DTN riboflavin biosynthesis protein ribF BEN31_07950 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BEN31_07955 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BEN31_07960 ENOG4105W7A Protein of unknown function (DUF503) BEN31_07965 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BEN31_07970 ENOG4105VHM ribosomal protein BEN31_07975 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BEN31_07980 ENOG4105CHV Transcription elongation factor NusA BEN31_07985 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BEN31_07995 ENOG4105WJF BEN31_08000 ENOG4105CYP glycoside hydrolase, family BEN31_08010 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BEN31_08015 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BEN31_08020 ENOG4105DZP Membrane-associated zinc metalloprotease BEN31_08025 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BEN31_08030 ENOG4105KNE Phosphatidate cytidylyltransferase BEN31_08035 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BEN31_08040 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BEN31_08050 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BEN31_08055 ENOG4105CE9 30S ribosomal protein S2 BEN31_08065 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_08070 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BEN31_08080 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BEN31_08085 ENOG4105CBS Chea signal transduction histidine kinase BEN31_08090 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BEN31_08100 ENOG4105FZW flagellar biosynthesis regulator FlhF BEN31_08105 ENOG4105D7B Flagellar biosynthesis protein flha BEN31_08110 ENOG4105D00 flagellar biosynthetic protein flhB BEN31_08115 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BEN31_08120 ENOG4105VS8 Flagellar biosynthetic protein fliq BEN31_08125 ENOG4105CN7 Flagellar biosynthetic protein FliP BEN31_08135 ENOG4107YTP response regulator receiver protein BEN31_08140 ENOG4105DD5 Flagellar motor switch protein BEN31_08145 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BEN31_08155 ENOG41068WV flagellar FlbD family protein BEN31_08160 ENOG4108JQA flagellar BEN31_08165 ENOG410822I Flagellar hook capping protein BEN31_08170 ENOG410696Y Flagellar hook-length control protein BEN31_08180 ENOG4106YF4 Flagellar biosynthesis chaperone BEN31_08195 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BEN31_08200 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BEN31_08205 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BEN31_08210 ENOG4108ZC9 flagellar basal-body rod protein flgc BEN31_08215 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BEN31_08225 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BEN31_08230 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BEN31_08235 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BEN31_08240 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BEN31_08245 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BEN31_08250 ENOG4105C79 DNA protecting protein DprA BEN31_08255 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BEN31_08260 ENOG4105CMV Succinyl-CoA synthetase subunit beta BEN31_08265 ENOG4105VM1 flagellar BEN31_08275 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BEN31_08280 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BEN31_08285 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BEN31_08290 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BEN31_08295 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BEN31_08305 ENOG4108BW8 UPF0109 protein BEN31_08310 ENOG4105K5M 30s ribosomal protein S16 BEN31_08320 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BEN31_08325 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BEN31_08330 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BEN31_08335 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BEN31_08340 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BEN31_08345 ENOG4105CHR reductase BEN31_08350 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BEN31_08355 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BEN31_08360 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BEN31_08365 ENOG4105CB5 ATP-dependent DNA helicase recG BEN31_08370 ENOG4105EJQ L-serine dehydratase BEN31_08380 ENOG4105DP4 dak2 domain fusion protein ylov BEN31_08385 ENOG4108ZAA Alkaline-shock protein BEN31_08390 ENOG4105VB9 50S ribosomal protein l28 BEN31_08400 ENOG4105FJ0 thiamine BEN31_08405 ENOG4105DJV ribulose-phosphate 3-epimerase BEN31_08410 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BEN31_08415 ENOG4105D9P serine threonine protein kinase BEN31_08420 ENOG4108ZF3 Phosphatase BEN31_08425 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BEN31_08430 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BEN31_08435 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BEN31_08440 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BEN31_08445 ENOG4105C25 Primosomal protein n' BEN31_08450 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BEN31_08460 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BEN31_08465 ENOG4105KC4 UPF0296 protein BEN31_08470 ENOG4105DSJ YicC domain protein BEN31_08480 ENOG4105F23 Fibronectin-binding protein BEN31_08485 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BEN31_08490 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BEN31_08495 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BEN31_08500 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) BEN31_08505 ENOG4107RIQ Sulfate adenylate transferase BEN31_08515 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BEN31_08520 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BEN31_08525 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BEN31_08530 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BEN31_08535 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BEN31_08540 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BEN31_08545 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BEN31_08550 ENOG4105CD3 dihydroorotase BEN31_08555 ENOG4105CXT aspartate transcarbamylase BEN31_08565 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BEN31_08570 ENOG4105C34 Pseudouridine synthase BEN31_08575 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BEN31_08585 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BEN31_08595 ENOG4105DBK s4 domain protein BEN31_08600 ENOG41067XK integral membrane protein BEN31_08605 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BEN31_08610 ENOG4105DFA alanine racemase domain protein BEN31_08615 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BEN31_08620 ENOG4105WR5 sporulation protein, YlmC YmxH family BEN31_08625 ENOG4105DKW ABC transporter BEN31_08630 ENOG4105VI0 Pts system, glucitol sorbitol-specific BEN31_08635 ENOG4105DZY Pts system, glucitol sorbitol-specific BEN31_08640 ENOG410787A Pts system, glucitol sorbitol-specific BEN31_08655 ENOG4105DKT Transcriptional regulator BEN31_08665 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BEN31_08670 ENOG4105FFI sigma-e processing peptidase spoiiga BEN31_08680 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BEN31_08685 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BEN31_08690 ENOG4105K67 small basic protein BEN31_08700 ENOG4108R2U division initiation protein BEN31_08705 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BEN31_08710 ENOG4105D4A Cell wall formation (By similarity) BEN31_08715 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BEN31_08720 ENOG4105CNI cell division protein FtsW BEN31_08725 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BEN31_08730 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BEN31_08735 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BEN31_08740 ENOG4105CJN penicillin-binding protein BEN31_08745 ENOG4105CJN penicillin-binding protein BEN31_08755 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BEN31_08760 ENOG4108V6E Cell division protein mraZ BEN31_08785 ENOG41067VY 50S ribosomal protein L32 BEN31_08790 ENOG4105KNH Nucleic acid-binding protein BEN31_08795 ENOG4105CDE UPF0348 protein BEN31_08800 ENOG41063PX domain protein BEN31_08805 ENOG4105D78 K07001 NTE family protein BEN31_08810 ENOG4105H20 Sporulation integral membrane protein YlbJ BEN31_08815 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BEN31_08820 ENOG4106H78 methyltransferase BEN31_08825 ENOG4105WUC UPF0298 protein BEN31_08850 ENOG4106UY4 Inherit from COG: Scp-like extracellular BEN31_08855 ENOG41080XQ Signal transduction protein with cbs domains BEN31_08870 ENOG41064X9 cytochrome C oxidase subunit IV BEN31_08875 ENOG4105CCU oxidase (Subunit III) BEN31_08880 ENOG4105BZ9 Cytochrome C oxidase, subunit I BEN31_08890 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BEN31_08900 ENOG4105CVP deoxyribo-dipyrimidine photolyase BEN31_08905 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BEN31_08910 ENOG4105CNI cell division protein FtsW BEN31_08920 ENOG4105CSV Glutaminase BEN31_08930 ENOG4108IAB Phoh family BEN31_08945 ENOG4105QA2 BEN31_08950 ENOG4105CI3 gtp-binding protein typa BEN31_08965 ENOG4105ECY inositol monophosphatase BEN31_08975 ENOG4108WQ8 UPF0637 protein BEN31_08985 ENOG4105CXN decarboxylase BEN31_09000 ENOG4107QN2 dihydrolipoyl dehydrogenase BEN31_09005 ENOG4105C7S Dehydrogenase BEN31_09010 ENOG4105CPP Dehydrogenase, E1 component BEN31_09030 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BEN31_09035 ENOG4108X4Q Hydrolase BEN31_09045 ENOG4105CN5 Metallo-Beta-Lactamase BEN31_09050 ENOG4105CPN adenine deaminase BEN31_09055 ENOG4107ZYR domain protein BEN31_09065 ENOG4105BZU Histidine kinase BEN31_09085 ENOG4105C5H ABC transporter BEN31_09095 ENOG4105C3F Signal peptidase i BEN31_09100 ENOG4105DM4 PTS System BEN31_09105 ENOG4105DE4 1-phosphofructokinase BEN31_09110 ENOG4105E98 transcriptional regulator DeoR family BEN31_09115 ENOG4107RBB ABC transporter, permease BEN31_09120 ENOG4105C19 ABC transporter BEN31_09125 ENOG4107X8C Efflux transporter RND family MFP subunit BEN31_09140 ENOG41067WU Molybdopterin converting factor (Subunit 1) BEN31_09145 ENOG4108ZAF Molybdopterin BEN31_09150 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BEN31_09155 ENOG4105CVM Molybdenum cofactor synthesis domain protein BEN31_09160 ENOG4105D06 uba thif-type nad fad binding protein BEN31_09165 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BEN31_09180 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BEN31_09185 ENOG4105D3R alkyl hydroperoxide reductase BEN31_09190 ENOG4105D8X mechanosensitive ion channel BEN31_09195 ENOG4106AUC UPF0180 protein BEN31_09205 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BEN31_09210 ENOG4105NQC Flavodoxin BEN31_09245 ENOG4108XRC Protein of unknown function (DUF458) BEN31_09250 ENOG4107IN1 Protein of unknown function (DUF1797) BEN31_09255 ENOG4105WEF catalase BEN31_09260 ENOG4105EPM Diguanylate phosphodiesterase BEN31_09265 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BEN31_09275 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein BEN31_09290 ENOG4105UIN BEN31_09295 ENOG4107R88 Chemotaxis protein (CheV) BEN31_09305 ENOG41085PJ rdd domain containing protein BEN31_09315 ENOG4105CHM Aminotransferase BEN31_09320 ENOG4105BZU Histidine kinase BEN31_09330 ENOG4105K4I Scp-like extracellular BEN31_09335 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BEN31_09340 ENOG4105CHR reductase BEN31_09345 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BEN31_09350 ENOG4105F6S Spore photoproduct lyase BEN31_09360 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BEN31_09365 ENOG4105KRI phosphocarrier protein (HPr BEN31_09375 ENOG4105CID antiterminator BEN31_09385 ENOG4105DC7 peptidase M24 BEN31_09390 ENOG4105C59 p-type ATPase BEN31_09405 ENOG4105F0V Cell wall hydrolase BEN31_09425 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BEN31_09430 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BEN31_09435 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BEN31_09440 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BEN31_09445 ENOG4108K88 Membrane BEN31_09455 ENOG4105E14 MotA TolQ exbB proton channel BEN31_09460 ENOG4105ER2 Ompa motb domain protein BEN31_09465 ENOG41090MY MarR family Transcriptional regulator BEN31_09470 ENOG4105BZU Histidine kinase BEN31_09480 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BEN31_09485 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BEN31_09490 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BEN31_09495 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BEN31_09505 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BEN31_09510 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BEN31_09515 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BEN31_09520 ENOG4105BZU Histidine kinase BEN31_09525 ENOG4108TGC Acyltransferase BEN31_09535 ENOG410900G Protein of unknown function (DUF421) BEN31_09545 ENOG4105D0M Protease HtpX homolog BEN31_09555 ENOG410681C small acid-soluble spore protein BEN31_09565 ENOG4108WZW RNA polymerase sigma BEN31_09570 ENOG4107TS3 membrane protein, TerC BEN31_09575 ENOG4107T5V SNARE associated Golgi BEN31_09580 ENOG4105BZU Histidine kinase BEN31_09600 ENOG4105V75 Transcriptional regulator BEN31_09620 ENOG4105CJW magnesium transporter BEN31_09630 ENOG4106849 propeptide, pepSY amd peptidase M4 BEN31_09640 ENOG41062D9 Histidine kinase BEN31_09645 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BEN31_09650 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_09655 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BEN31_09660 ENOG4107Y2X deaminase BEN31_09665 ENOG4108ZHJ Organic hydroperoxide resistance protein BEN31_09670 ENOG4105K56 Transcriptional regulator BEN31_09695 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BEN31_09700 ENOG4105CIY formyltetrahydrofolate deformylase BEN31_09710 ENOG41080TC multidrug resistance protein BEN31_09715 ENOG410839T multidrug resistance protein BEN31_09720 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BEN31_09725 ENOG4108428 Inherit from COG: -acetyltransferase BEN31_09740 ENOG4105K7K Transcriptional regulator BEN31_09745 ENOG4108S4H thioesterase Superfamily protein BEN31_09750 ENOG4107TUM Amidinotransferase BEN31_09755 ENOG4108JQ7 (ABC) transporter BEN31_09760 ENOG4107SN7 NLP P60 protein BEN31_09765 ENOG4105DTQ mandelate racemase muconate lactonizing BEN31_09770 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BEN31_09780 ENOG4105C3U ABC transporter BEN31_09785 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BEN31_09790 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BEN31_09795 ENOG4108ME1 Peptidase M55 D-aminopeptidase BEN31_09805 ENOG4105C0H protease BEN31_09815 ENOG4107R7I amino acid BEN31_09825 ENOG4107RHR regulatoR BEN31_09830 ENOG4105CHR reductase BEN31_09835 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BEN31_09845 ENOG4105C7S Dehydrogenase BEN31_09850 ENOG4105CPP Dehydrogenase, E1 component BEN31_09855 ENOG4107RUY (E1 component), alpha subunit BEN31_09860 ENOG4105CPQ Dehydrogenase BEN31_09875 ENOG4105DT3 PTS system, galactitol-specific IIc component BEN31_09885 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BEN31_09895 ENOG4107GRR phosphate transport regulator BEN31_09900 ENOG4105CJ3 phosphate transporter BEN31_09915 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BEN31_09920 ENOG410635T phage-like element pbsx protein BEN31_09925 ENOG4105K7W phage-related replication protein BEN31_09940 ENOG4105I03 Flagellin BEN31_09945 ENOG4105I03 Flagellin BEN31_09955 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BEN31_09985 ENOG4105DJ2 Major Facilitator Superfamily BEN31_09990 ENOG4107RSM transcriptional regulator BEN31_10055 ENOG4105I03 Flagellin BEN31_10070 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BEN31_10090 ENOG4105C28 cystathionine BEN31_10095 ENOG4105C28 cystathionine BEN31_10170 ENOG4107A88 BEN31_10175 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BEN31_10180 ENOG4105DWF phosphomethylpyrimidine kinase BEN31_10185 ENOG4105D06 uba thif-type nad fad binding protein BEN31_10190 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BEN31_10205 ENOG4108VEU Thiamine monophosphate synthase BEN31_10210 ENOG4105ETU transcriptional activator (TenA BEN31_10220 ENOG4107S1Q Phosphatase BEN31_10225 ENOG4105EMS pseudouridine synthase BEN31_10230 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BEN31_10240 ENOG4106EFP UPF0738 protein BEN31_10245 ENOG4105MIX Adenylate cyclase BEN31_10250 ENOG4105E4C Lytic transglycosylase catalytic BEN31_10255 ENOG4108Z18 K06886 hemoglobin BEN31_10260 ENOG4105T58 Dithiol-disulfide isomerase BEN31_10265 ENOG4105DPN Oligoendopeptidase f BEN31_10275 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BEN31_10280 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BEN31_10285 ENOG4108ZCF integral membrane protein BEN31_10290 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BEN31_10305 ENOG4108JQ7 (ABC) transporter BEN31_10315 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BEN31_10320 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BEN31_10325 ENOG4108J59 Extracellular solute-binding protein, family 5 BEN31_10330 ENOG4105C31 Tryptophanyl-tRNA synthetase BEN31_10340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BEN31_10355 ENOG4108JQ7 (ABC) transporter BEN31_10360 ENOG4105C3U ABC transporter BEN31_10370 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BEN31_10375 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BEN31_10390 ENOG4107RMD Basic membrane lipoprotein BEN31_10420 ENOG4105DBV ornithine carbamoyltransferase BEN31_10430 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BEN31_10435 ENOG4105C8Y Acetylornithine aminotransferase BEN31_10440 ENOG4105CAS nag kinase BEN31_10450 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BEN31_10460 ENOG4105IQ5 FAD linked oxidase domain protein BEN31_10465 ENOG4105VG1 fes assembly suf system protein BEN31_10470 ENOG4108MXZ Esterase BEN31_10475 ENOG4108KP7 hydrolase BEN31_10485 ENOG41073B9 BEN31_10495 ENOG4107AYK membrAne BEN31_10500 ENOG4105EPR degv family BEN31_10505 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_10510 ENOG4105DIH basic membrane BEN31_10515 ENOG4105QNR S1 RNA binding domain protein BEN31_10520 ENOG4108VPT UPF0234 protein BEN31_10560 ENOG4105DY8 decarboxylase BEN31_10585 ENOG4106HBX Transcriptional Regulator AraC Family BEN31_10590 ENOG4105UQX Mate efflux family protein BEN31_10610 ENOG4105CAQ asparagine synthetase BEN31_10620 ENOG4106BKT UPF0344 protein BEN31_10625 ENOG4105ERH Fumarylacetoacetate hydrolase BEN31_10680 ENOG4105EYH Exonuclease BEN31_10690 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BEN31_10720 ENOG4108KK1 membrane protein AbrB duplication BEN31_10735 ENOG41060YP BEN31_10740 ENOG4108KGH TRANSCRIPTIONal BEN31_10750 ENOG4108IPW abc transporter atp-binding protein BEN31_10755 ENOG4105CM4 permease protein BEN31_10760 ENOG4105DHS permease protein BEN31_10765 ENOG41067XF inhibitor BEN31_10770 ENOG4105E5M Multidrug resistance protein D BEN31_10775 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BEN31_10790 ENOG4105XVF Competence transcription factor BEN31_10810 ENOG4106YBV Methyl-accepting chemotaxis BEN31_10815 ENOG4107TB6 phosphoglycerate mutase BEN31_10820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_10825 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BEN31_10835 ENOG4105CEY Amp-dependent synthetase and ligase BEN31_10840 ENOG4105DF9 Lipoate-protein, ligase BEN31_10845 ENOG4108RQ5 Beta-lactamase domain-containing protein BEN31_10850 ENOG4106AXD BEN31_10860 ENOG4105DER m42 family BEN31_10865 ENOG4105ECB domain protein BEN31_10875 ENOG4105C1Q protoporphyrinogen oxidase BEN31_10880 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BEN31_10885 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BEN31_10890 ENOG4105BZ4 penicillin-binding protein BEN31_10895 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BEN31_10925 ENOG4105K59 histidine triad (HIT) protein BEN31_10930 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BEN31_10935 ENOG4105NBU tryptophan transport protein BEN31_10970 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BEN31_10985 ENOG4106D4I domain protein BEN31_10990 ENOG4107VRP DNA repair exonuclease BEN31_11000 ENOG4105CGU Enoyl-CoA hydratase BEN31_11010 ENOG4105NCW Trka-c domain protein BEN31_11015 ENOG4107S91 Sodium hydrogen exchanger BEN31_11025 ENOG4105D4P Coproporphyrinogen iii oxidase BEN31_11035 ENOG4105WZB UPF0342 protein BEN31_11040 ENOG4108UH6 UPF0754 membrane protein BEN31_11050 ENOG410839P BEN31_11080 ENOG4105BZ1 (ABC) transporter BEN31_11085 ENOG4105BZ1 (ABC) transporter BEN31_11095 ENOG4105F0I Aminotransferase BEN31_11100 ENOG4107VMI polysaccharide deacetylase BEN31_11105 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BEN31_11110 ENOG4105D64 Mechanosensitive ion channel BEN31_11115 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BEN31_11120 ENOG4105WMR Protein CrcB homolog BEN31_11125 ENOG4106A8V Protein CrcB homolog BEN31_11135 ENOG4105C37 (CBS) domain BEN31_11145 ENOG4105C37 (CBS) domain BEN31_11150 ENOG4105F6E Acyl-transferase BEN31_11155 ENOG4108AEY RNA polymerase sigma factor BEN31_11160 ENOG4105J37 BEN31_11175 ENOG4105G6Z alkaline phosphatase BEN31_11180 ENOG4105ED1 spovr family BEN31_11185 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BEN31_11190 ENOG4105KPV Transcriptional regulator BEN31_11195 ENOG4105CH6 catalase BEN31_11215 ENOG4105WH1 Two component transcriptional regulator luxr family BEN31_11220 ENOG4105BZU Histidine kinase BEN31_11230 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BEN31_11235 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BEN31_11245 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BEN31_11250 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BEN31_11255 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BEN31_11270 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BEN31_11275 ENOG4107YBY Hydrolase BEN31_11285 ENOG4108YBP pseudouridine synthase BEN31_11300 ENOG4105BZU Histidine kinase BEN31_11330 ENOG4105BZU Histidine kinase BEN31_11335 ENOG4105VEQ Cold shock protein BEN31_11345 ENOG4105CS1 NAD(P)H quinone oxidoreductase BEN31_11350 ENOG4105C0R drug resistance transporter emrb qaca subfamily BEN31_11355 ENOG4105CW7 secretion protein, HlyD family BEN31_11360 ENOG4106AKX UPF0229 protein BEN31_11365 ENOG4105CYN Serine protein kinase BEN31_11375 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BEN31_11385 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BEN31_11420 ENOG4105CJ1 ABC, transporter BEN31_11440 ENOG4105E0M Sulfatase BEN31_11580 ENOG4105G5W regulator Fur family BEN31_11585 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BEN31_11590 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BEN31_11595 ENOG4107NBY Membrane BEN31_11600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BEN31_11605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BEN31_11610 ENOG4105DEF Extracellular solute-binding protein, family 5 BEN31_11615 ENOG4108JQ7 (ABC) transporter BEN31_11620 ENOG4105C3U ABC transporter BEN31_11625 ENOG4105BZ1 (ABC) transporter BEN31_11630 ENOG4105EVI UPF0374 protein BEN31_11645 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BEN31_11650 ENOG4106BXE BEN31_11655 ENOG4105CEN a g-specific adenine glycosylase BEN31_11660 ENOG41067AE Membrane-bound metal-dependent hydrolase BEN31_11705 ENOG4106DF4 Sigma-70, region 4 BEN31_11710 ENOG4105F0F Oxalate decarboxylase BEN31_11725 ENOG4105EJV Membrane BEN31_11730 ENOG4105CKK Glycosyl transferase, family 2 BEN31_11750 ENOG4105KC9 Modulates RecA activity (By similarity) BEN31_11755 ENOG4105ECP epimerase BEN31_11770 ENOG4107Y03 Nitroreductase BEN31_11795 ENOG410834F Transcriptional regulator BEN31_11805 ENOG4108YYS metal-dependent hydrolase (By similarity) BEN31_11825 ENOG4107TDE lipolytic protein G-D-S-L family BEN31_11845 ENOG410839T multidrug resistance protein BEN31_11890 ENOG4105C22 threonyL-tRNA synthetase BEN31_11905 ENOG4108RWP Major Facilitator Superfamily protein BEN31_11910 ENOG4107TXC Transcriptional regulator BEN31_11920 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BEN31_11935 ENOG4105D7N magnesium and cobalt transport protein CorA BEN31_11960 ENOG4105D8X mechanosensitive ion channel BEN31_11970 ENOG4105CDY transcriptional regulatory protein BEN31_11990 ENOG4108IUX (ABC) transporter BEN31_12005 ENOG4105UPD Calcium Proton BEN31_12015 ENOG4108ISG Major Facilitator BEN31_12020 ENOG4107U9T Pfam:Ribonuclease_BN BEN31_12030 ENOG4105KJF protein tyrosine phosphatase BEN31_12035 ENOG4105BZG amino acid carrier protein BEN31_12045 ENOG4107RKG DJ-1/PfpI family BEN31_12050 ENOG4105CGH 5'-nucleotidase BEN31_12060 ENOG4107414 GntR family transcriptional regulator BEN31_12065 ENOG4105CG3 alpha amylase, catalytic region BEN31_12070 ENOG4105C5Y PTS System BEN31_12080 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_12085 ENOG4105DY8 decarboxylase BEN31_12110 ENOG4105NX3 Membrane BEN31_12120 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BEN31_12130 ENOG4108RPX mosc domain containing protein BEN31_12135 ENOG41084AG Acylphosphatase BEN31_12145 ENOG4105U3E Transcriptional regulator BEN31_12150 ENOG4105PY6 Phenolic acid decarboxylase BEN31_12170 ENOG4108MRH transcriptional regulatory protein BEN31_12185 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BEN31_12195 ENOG4105E6M Sulphatase-modifying factor protein BEN31_12200 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BEN31_12220 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BEN31_12225 ENOG4105FDU atp-dependent rna helicase BEN31_12230 ENOG4105C5H ABC transporter BEN31_12235 ENOG4105DXB Major Facilitator superfamily BEN31_12240 ENOG4107SWG transcriptional regulator MERR family BEN31_12245 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) BEN31_12250 ENOG4105C5H ABC transporter BEN31_12255 ENOG4107TVC Glycosyl transferase, family 2 BEN31_12260 ENOG4105CUB amino acid BEN31_12265 ENOG4105C8P )-transporter BEN31_12270 ENOG4107RVG penicillin-binding protein BEN31_12275 ENOG4105EU0 Major facilitator Superfamily BEN31_12280 ENOG41090R9 glycosyltransferase BEN31_12285 ENOG4107R51 Glycosyl transferase, family 2 BEN31_12290 ENOG41090R9 glycosyltransferase BEN31_12300 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BEN31_12305 ENOG4108R1P BEN31_12330 ENOG4105HX0 Transcriptional regulator BEN31_12335 ENOG4105F8D glycoside hydrolase family 4 BEN31_12350 ENOG4105C3M thioredoxin reductase BEN31_12390 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BEN31_12395 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BEN31_12400 ENOG4105CBD Diacylglycerol kinase BEN31_12405 ENOG4105DU0 nucleoside hydrolase BEN31_12415 ENOG4108IG5 Transcriptional regulator BEN31_12420 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BEN31_12425 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BEN31_12430 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BEN31_12435 ENOG4105CK7 Sodium proline symporter BEN31_12440 ENOG4105KT7 mgtC SapB transporter BEN31_12445 ENOG4105G6Z alkaline phosphatase BEN31_12450 ENOG4105CRN Aminoglycoside phosphotransferase BEN31_12480 ENOG4105C1G acyl-Coa dehydrogenase BEN31_12495 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BEN31_12530 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BEN31_12535 ENOG4105C4R Atp-dependent dna helicase BEN31_12540 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BEN31_12555 ENOG4105CBC glutamate synthase BEN31_12560 ENOG4105KGF protein, YerC YecD BEN31_12575 ENOG4107S4Y M20 DapE family protein YgeY BEN31_12590 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BEN31_12610 ENOG4105C12 Phosphoribosylglycinamide synthetase BEN31_12615 ENOG4105DC1 bifunctional purine biosynthesis protein purh BEN31_12620 ENOG4108V3E phosphoribosylglycinamide formyltransferase BEN31_12625 ENOG4105CXB phosphoribosylaminoimidazole synthetase BEN31_12635 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BEN31_12645 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BEN31_12650 ENOG4105C8V SAICAR synthetase BEN31_12655 ENOG4105C83 adenylosuccinate lyase BEN31_12660 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BEN31_12665 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BEN31_12675 ENOG4108U5N UPF0316 protein BEN31_12685 ENOG4105C7N Xanthine uracil vitamin C permease BEN31_12690 ENOG4105GZI Transcriptional regulator BEN31_12695 ENOG4108RWP Major Facilitator Superfamily protein BEN31_12710 ENOG4105KNA -acetyltransferase BEN31_12740 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BEN31_12765 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BEN31_12770 ENOG4105W4W Transcriptional regulator BEN31_12775 ENOG4108UIN ybak prolyl-trna synthetase associated region BEN31_12780 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BEN31_12795 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BEN31_12805 ENOG4105C85 amino acid BEN31_12810 ENOG4107STQ Multicopper oxidase BEN31_12855 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BEN31_12860 ENOG4108U05 Transcriptional regulator BEN31_12875 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BEN31_12880 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BEN31_12885 ENOG4108TYN CAAX amino terminal protease family protein BEN31_12895 ENOG41081VB Hydrolase BEN31_12900 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BEN31_12905 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BEN31_12910 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BEN31_12915 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BEN31_12920 ENOG4105C5H ABC transporter BEN31_12925 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BEN31_12930 ENOG410801F ribosomal-protein-alanine acetyltransferase BEN31_12935 ENOG41072GX Peptidase M22 Glycoprotease BEN31_12940 ENOG4105K8N protein family UPF0079, ATPase BEN31_12945 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BEN31_13000 ENOG4108UMN azlc family BEN31_13020 ENOG4105CPC Aldo Keto reductase BEN31_13025 ENOG4106NZI LysR family Transcriptional regulator BEN31_13030 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BEN31_13040 ENOG4108JCI Transcriptional regulator BEN31_13055 ENOG4108TVJ Nitroreductase BEN31_13060 ENOG41090MY MarR family Transcriptional regulator BEN31_13065 ENOG4105NAE bifunctional deaminase-reductase domain protein BEN31_13070 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BEN31_13075 ENOG4105VDT -acetyltransferase BEN31_13120 ENOG4107RB3 L-asparaginase BEN31_13155 ENOG4105C0R drug resistance transporter emrb qaca subfamily BEN31_13170 ENOG4105VUF Transcriptional regulator BEN31_13175 ENOG4105DQ4 alcohol dehydrogenase BEN31_13180 ENOG4108VJ1 Transcriptional regulator (CarD family BEN31_13185 ENOG4105VEQ Cold shock protein BEN31_13190 ENOG4105RHY Pfam:UPF0157 BEN31_13200 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BEN31_13215 ENOG4105DJ2 Major Facilitator Superfamily BEN31_13225 ENOG4105NF4 modulator of drug activity BEN31_13230 ENOG4105GZI Transcriptional regulator BEN31_13270 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BEN31_13280 ENOG4107QKR Dehydrogenase BEN31_13305 ENOG41064BQ Phosphatase BEN31_13315 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BEN31_13320 ENOG4105WN5 stage II sporulation protein BEN31_13325 ENOG4107SGM protein serine threonine phosphatase BEN31_13330 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BEN31_13335 ENOG4105FUA antagonist BEN31_13340 ENOG4107MMM Anti-sigma-factor antagonist BEN31_13345 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BEN31_13355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BEN31_13360 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BEN31_13375 ENOG4105CKV Membrane BEN31_13380 ENOG410905X membrane-flanked domain protein BEN31_13385 ENOG4105C1J atp-dependent rna helicase BEN31_13400 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BEN31_13405 ENOG4105CPF Cell wall formation (By similarity) BEN31_13410 ENOG4105SZ6 Thioredoxin BEN31_13430 ENOG4105CJ1 ABC, transporter BEN31_13440 ENOG4106F5Q Membrane BEN31_13445 ENOG4107QJT sodium dicarboxylate symporter BEN31_13450 ENOG4108MRH transcriptional regulatory protein BEN31_13455 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BEN31_13460 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BEN31_13470 ENOG4107BMA Transglycosylase associated protein BEN31_13475 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BEN31_13515 ENOG4105C0X amino acid BEN31_13525 ENOG4107R8N Glycosyl transferase, family 2 BEN31_13530 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BEN31_13545 ENOG4105C9U ATP-dependent DNA helicase RecQ BEN31_13550 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BEN31_13555 ENOG410631K Membrane BEN31_13560 ENOG4106AXJ AraC family transcriptional regulator BEN31_13565 ENOG4105DRR Transcriptional regulator, GntR family BEN31_13570 ENOG4105VCH membrane BEN31_13590 ENOG410606W general stress protein BEN31_13595 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BEN31_13600 ENOG4105HMZ Methyltransferase BEN31_13605 ENOG4105ETD TRANSCRIPTIONal BEN31_13615 ENOG4105XJB lipolytic protein G-D-S-L family BEN31_13620 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BEN31_13625 ENOG4107258 Transcriptional regulator BEN31_13635 ENOG4105P4J Allophanate hydrolase, subunit 1 BEN31_13640 ENOG4105CFM UPF0317 protein BEN31_13645 ENOG4105C5A transporter BEN31_13650 ENOG4105E7W lamb ycsf family protein BEN31_13660 ENOG4105X3H Excalibur domain protein BEN31_13685 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_13690 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BEN31_13705 ENOG4108T5E Copper resistance protein BEN31_13710 ENOG4105KTB nuclear export factor GLE1 BEN31_13715 ENOG4105DYS nad(p)h dehydrogenase (quinone) BEN31_13720 ENOG4105C26 Dehydrogenase BEN31_13725 ENOG4107QTZ amino acid BEN31_13730 ENOG4108JPW Aminotransferase BEN31_13740 ENOG4105YVS arsR family transcriptional regulator BEN31_13750 ENOG4105R8C Transcriptional regulator BEN31_13760 ENOG4105CFH Aspartokinase BEN31_13770 ENOG4108PGP mmge prpd family protein BEN31_13775 ENOG4105CH2 amidohydrolase BEN31_13785 ENOG4108HW4 amino acid AbC transporter BEN31_13790 ENOG4105EAB amino acid AbC transporter BEN31_13795 ENOG4108XSB acetyltransferase, (GNAT) family BEN31_13800 ENOG4105CPU Monooxygenase BEN31_13810 ENOG4105DUX Transporter BEN31_13815 ENOG4108IQI permease BEN31_13825 ENOG4105DRP amino acid AbC transporter BEN31_13830 ENOG4105CDA abc transporter atp-binding protein BEN31_13850 ENOG4105SX7 Transporter BEN31_13865 ENOG4108IUW ABC transporter BEN31_13905 ENOG4105CEY Amp-dependent synthetase and ligase BEN31_13915 ENOG4105F38 ABC transporter, permease BEN31_13920 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BEN31_13950 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_13960 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BEN31_13970 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BEN31_13980 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BEN31_13985 ENOG4105E5Q amino acid AbC transporter BEN31_13990 ENOG4107R5R arsenical pump membrane protein BEN31_13995 ENOG4107YHD transcriptional regulator BEN31_14000 ENOG4105C26 Dehydrogenase BEN31_14010 ENOG410756H nucleotidyltransferase BEN31_14020 ENOG4105I82 acetyl xylan esterase BEN31_14025 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BEN31_14030 ENOG4105C5Q Transcriptional regulator BEN31_14035 ENOG41089UC methyltransferase, type 11 BEN31_14040 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BEN31_14045 ENOG41079KZ Major Facilitator Superfamily BEN31_14055 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BEN31_14060 ENOG4107RMH nh(3)-dependent nad( ) synthetase BEN31_14065 ENOG4105EIG urea carboxylase-associated protein 1 BEN31_14095 ENOG4105TRI Hydrolase BEN31_14115 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BEN31_14145 ENOG4107SQ8 Glycine betaine BEN31_14150 ENOG4108IJ7 Glycine betaine BEN31_14160 ENOG4108TTB tellurium resistance protein BEN31_14185 ENOG4107TS3 membrane protein, TerC BEN31_14190 ENOG4106FN3 tellurium resistance protein BEN31_14195 ENOG4106FN3 tellurium resistance protein BEN31_14200 ENOG4108N0M stress protein BEN31_14205 ENOG4105DEN Luciferase family BEN31_14215 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BEN31_14240 ENOG4108SDH ABC, transporter BEN31_14245 ENOG4108IUW ABC transporter BEN31_14250 ENOG4107Y7X LytTR BEN31_14260 ENOG4107SET aldo keto reductase BEN31_14270 ENOG41060AI SEC-C motif BEN31_14285 ENOG4105CSV Glutaminase BEN31_14295 ENOG4105D74 hydrolase BEN31_14310 ENOG4105CUB amino acid BEN31_14320 ENOG41067TZ transcriptional regulator, MarR family BEN31_14325 ENOG4105E2A Dehydrogenase BEN31_14335 ENOG4105J7D transcriptional regulator BEN31_14345 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_14365 ENOG4105C2C drug resistance transporter, Bcr CflA BEN31_14380 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BEN31_14385 ENOG4108J5H Homocysteine s-methyltransferase BEN31_14390 ENOG4108IQI permease BEN31_14405 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_14410 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BEN31_14415 ENOG4108YRF PTS System BEN31_14420 ENOG4105DM4 PTS System BEN31_14425 ENOG4105C8I hydrolase, family 38 BEN31_14430 ENOG4105EVU fructokinase BEN31_14435 ENOG4105EMD TRANSCRIPTIONal BEN31_14450 ENOG4105CS2 ec 3.2.1.21 BEN31_14455 ENOG4105C5Y PTS System BEN31_14460 ENOG4105CID antiterminator BEN31_14470 ENOG4107QTZ amino acid BEN31_14475 ENOG4105C72 UPF0176 protein BEN31_14480 ENOG4107SCQ Iron-containing alcohol dehydrogenase BEN31_14495 ENOG4105EWC Purine nucleoside phosphorylase BEN31_14515 ENOG4108SUT Major Facilitator Superfamily BEN31_14520 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BEN31_14525 ENOG41087NI Sulfite exporter TauE/SafE BEN31_14530 ENOG4105VFE sira family BEN31_14535 ENOG4107TPS domain protein BEN31_14540 ENOG4105VFE sira family BEN31_14545 ENOG4105WZW rhodanese family BEN31_14550 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BEN31_14555 ENOG4105XTG Pfam:DUF156 BEN31_14575 ENOG4105C7Z Conserved Protein BEN31_14580 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BEN31_14585 ENOG4105CXY transporter BEN31_14590 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BEN31_14610 ENOG4105YA8 Transcriptional regulator BEN31_14650 ENOG4105DA5 (ABC) transporter BEN31_14690 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BEN31_14695 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BEN31_14700 ENOG4107U5W ybbr family BEN31_14705 ENOG4105C8B TIGR00159 family BEN31_14715 ENOG4105EMN RNA polymerase sigma factor BEN31_14750 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BEN31_14770 ENOG4105D17 glycoside hydrolase, family 3 domain protein BEN31_14775 ENOG4105EHZ conserved protein UCP016719 BEN31_14785 ENOG4105CHH sulfate transporter BEN31_14815 ENOG4108NMV polysaccharide deacetylase BEN31_14830 ENOG4105D1F ATP-binding protein BEN31_14870 ENOG4108UJD 30S ribosomal protein S9 BEN31_14875 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BEN31_14880 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BEN31_14885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BEN31_14890 ENOG4108JJB ABC transporter BEN31_14895 ENOG4108JJB ABC transporter BEN31_14900 ENOG4108ZT0 50S ribosomal protein l17 BEN31_14905 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BEN31_14910 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BEN31_14915 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BEN31_14925 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BEN31_14935 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BEN31_14940 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BEN31_14945 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BEN31_14950 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BEN31_14955 ENOG4105VPB 50S ribosomal protein L30 BEN31_14960 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BEN31_14965 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BEN31_14970 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BEN31_14975 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BEN31_14980 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BEN31_14985 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BEN31_14990 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BEN31_14995 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BEN31_15000 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BEN31_15005 ENOG41082SA 50s ribosomal protein l29 BEN31_15010 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BEN31_15015 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BEN31_15020 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BEN31_15025 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BEN31_15030 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BEN31_15035 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BEN31_15040 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BEN31_15045 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BEN31_15050 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BEN31_15055 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BEN31_15065 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BEN31_15070 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BEN31_15075 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BEN31_15080 ENOG4105XPM ribosomal protein BEN31_15085 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BEN31_15090 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BEN31_15095 ENOG4107Y49 methyltransferase BEN31_15100 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BEN31_15105 ENOG4108VZM 50s ribosomal protein L10 BEN31_15110 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BEN31_15115 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BEN31_15120 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BEN31_15135 ENOG4105M0M Tetracycline resistance protein BEN31_15140 ENOG4105C2N RNA methyltransferase TrmH family group 3 BEN31_15145 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BEN31_15150 ENOG4105C8N cysteinyl-tRNA synthetase BEN31_15155 ENOG4105D7W serine acetyltransferase BEN31_15160 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BEN31_15165 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BEN31_15170 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BEN31_15175 ENOG4105CTP PilT protein domain protein BEN31_15180 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BEN31_15185 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BEN31_15195 ENOG41066A3 ATP guanido phosphotransferase BEN31_15200 ENOG4108Z0C Uvrb UvrC protein BEN31_15285 ENOG4105CRK lysyL-tRNA synthetase BEN31_15290 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BEN31_15300 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BEN31_15305 ENOG4105KRF dihydroneopterin aldolase BEN31_15310 ENOG4105EEI dihydropteroate synthase BEN31_15315 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BEN31_15320 ENOG4105DDQ anthranilate synthase BEN31_15325 ENOG4105CRQ synthase (Component I) BEN31_15330 ENOG4105C6T cysteine synthase BEN31_15335 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BEN31_15340 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BEN31_15345 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BEN31_15350 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BEN31_15355 ENOG4108UGV hypoxanthine phosphoribosyltransferase BEN31_15360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BEN31_15390 ENOG41060GV RNA binding s1 domain protein BEN31_15405 ENOG4105VYY sporulation protein yabp BEN31_15410 ENOG41082I2 s4 domain protein BEN31_15415 ENOG4108IY2 MazG family BEN31_15425 ENOG4108M14 stage v sporulation protein t BEN31_15430 ENOG4108JA2 transcriptioN-repair coupling factor BEN31_15440 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BEN31_15445 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BEN31_15450 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BEN31_15455 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BEN31_15465 ENOG4105KME endoribonuclease L-psp BEN31_15470 ENOG4105DFT pur operon repressor BEN31_15475 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BEN31_15480 ENOG4105XEW small acid-soluble spore protein BEN31_15485 ENOG4105W42 Veg protein BEN31_15490 ENOG4105XFA sporulation peptidase YabG BEN31_15495 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BEN31_15505 ENOG41069ER domain protein BEN31_15510 ENOG4105F8V Hydrolase, tatD family BEN31_15515 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BEN31_15520 ENOG4105KRN Transcriptional regulator, abrb family BEN31_15525 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BEN31_15530 ENOG4105VC4 domain protein BEN31_15535 ENOG41060K3 Methyltransferase BEN31_15540 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) BEN31_15545 ENOG4105MA4 psp1 domain protein BEN31_15550 ENOG4105FA2 dna polymerase iii BEN31_15555 ENOG4105XVJ Protein of unknown function (DUF327) BEN31_15560 ENOG4105X0R protein from nitrogen regulatory protein P-II BEN31_15565 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BEN31_15570 ENOG4105CXN decarboxylase BEN31_15575 ENOG4105CDW Resistance protein BEN31_15615 ENOG41067KS pro-sigma K processing BEN31_15625 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BEN31_15630 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BEN31_15635 ENOG4105C6E dna polymerase iii BEN31_15645 ENOG4108Z6B deaminase BEN31_15650 ENOG4105GTG Isochorismatase BEN31_15655 ENOG4105VRS hydrolase family 18 BEN31_15665 ENOG4105ZMH deoxynucleoside kinase BEN31_15675 ENOG4105FKZ Methyl-accepting chemotaxis BEN31_15680 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BEN31_15685 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BEN31_15690 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BEN31_15695 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BEN31_15705 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BEN31_15740 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BEN31_15745 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BEN31_15755 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BEN31_15760 ENOG410848D S4 domain protein YaaA BEN31_15765 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BEN31_15770 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BEN31_15780 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BEN31_15785 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BEN31_15795 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BEN31_15800 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BEN31_15805 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BEN31_15820 ENOG4107QJE Chromosome Partitioning Protein BEN31_15825 ENOG4105FA0 parb-like partition protein BEN31_15830 ENOG4108ZDA Sporulation protein YyaC BEN31_15850 ENOG4105VDK protein, conserved in bacteria BEN31_15855 ENOG4105C3G gtp-binding protein BEN31_15860 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BEN31_15865 ENOG4108UUM single-stranded DNA-binding protein BEN31_15870 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BEN31_15875 ENOG4108IJ8 ABC transporter BEN31_15880 ENOG4105E90 ABC transporter BEN31_15885 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BEN31_15890 ENOG4105FBA Phospholipase Carboxylesterase BEN31_15895 ENOG4105CS1 NAD(P)H quinone oxidoreductase BEN31_15900 ENOG4105CH6 catalase BEN31_15910 ENOG4105JVQ RNA Polymerase BEN31_15915 ENOG4108P49 AntiSigma factor BEN31_15920 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BEN31_15925 ENOG4108XMW Membrane BEN31_15930 ENOG4105BZR domain protein BEN31_15935 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BEN31_15940 ENOG4105DJ2 Major Facilitator Superfamily BEN31_15950 ENOG4108SA1 esterase BEN31_15960 ENOG410874W AraC family transcriptional regulator BEN31_15965 ENOG4105WQT MbtH domain protein BEN31_15970 ENOG4105CEY Amp-dependent synthetase and ligase BEN31_15975 ENOG4105WQI isochorismatase BEN31_15980 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BEN31_15985 ENOG4105E4F Isochorismate synthase BEN31_15990 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BEN31_15995 ENOG4105NIV Esterase BEN31_16005 ENOG4106K80 BEN31_16010 ENOG4105CDU Replicative dna helicase BEN31_16015 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BEN31_16020 ENOG4106A3M Cytochrome p-450 BEN31_16025 ENOG4105ST3 Transcriptional regulator BEN31_16030 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BEN31_16045 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BEN31_16070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BEN31_16075 ENOG4105BZU Histidine kinase BEN31_16090 ENOG4105Q2H domain protein BEN31_16095 ENOG4105C0H protease BEN31_16100 ENOG4105WQG acetyltransferase BEN31_16120 ENOG4108V7D UPF0397 protein BEN31_16130 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BEN31_16140 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BEN31_16150 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_16170 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) BEN31_16175 ENOG41067QW Transcriptional regulator BEN31_16180 ENOG4105CJ1 ABC, transporter BEN31_16200 ENOG4108S3Y transcriptional regulator BEN31_16210 ENOG4105CS2 ec 3.2.1.21 BEN31_16245 ENOG4105E2X shikimate dehydrogenase BEN31_16255 ENOG4105ETE Transcriptional regulator (LacI family BEN31_16260 ENOG4105C85 amino acid BEN31_16295 ENOG4105C5Y PTS System BEN31_16300 ENOG4105CS2 ec 3.2.1.21 BEN31_16305 ENOG4105CID antiterminator BEN31_16310 ENOG410780I phosphoprotein phosphatase activity BEN31_16320 ENOG4105C19 ABC transporter BEN31_16330 ENOG4107Y80 Major Facilitator superfamily BEN31_16335 ENOG4105YA8 Transcriptional regulator BEN31_16340 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BEN31_16345 ENOG4107QQ0 gntp family BEN31_16350 ENOG4105BZW Glycerate kinase BEN31_16355 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BEN31_16360 ENOG4105CJ1 ABC, transporter BEN31_16380 ENOG4105C4C beta-galactosidase BEN31_16390 ENOG4105EG2 ABC transporter, permease BEN31_16400 ENOG4107FKK extracellular solute-binding protein family 1 BEN31_16410 ENOG4105DUM transcriptional regulator, lysR family BEN31_16430 ENOG4106KNT transcriptional regulator BEN31_16435 ENOG4105CMG Carbohydrate kinase BEN31_16440 ENOG4105C6Z Gluconate BEN31_16445 ENOG4105F1N DNA alkylation repair BEN31_16455 ENOG4105FKZ Methyl-accepting chemotaxis BEN31_16460 ENOG4105EE0 oxidoreductase BEN31_16465 ENOG4105W1Y Transcriptional regulator BEN31_16470 ENOG410667J hydrolase BEN31_16490 ENOG4105EXC Acyl-transferase BEN31_16500 ENOG4107RHR regulatoR BEN31_16505 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BEN31_16510 ENOG4105D9N nucleoside BEN31_16515 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BEN31_16520 ENOG4105FS7 Transcriptional regulator BEN31_16525 ENOG4108TVJ Nitroreductase BEN31_16530 ENOG41067V3 Antibiotic biosynthesis monooxygenase BEN31_16535 ENOG4107G87 m6 family metalloprotease domain protein BEN31_16565 ENOG4105ETU transcriptional activator (TenA BEN31_16570 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BEN31_16575 ENOG4108JJB ABC transporter BEN31_16580 ENOG4108W7F transporter, permease BEN31_16590 ENOG4108XI2 Domain of unknown function (DUF1963) BEN31_16595 ENOG4105CID antiterminator BEN31_16600 ENOG4105C5Y PTS System BEN31_16605 ENOG4105CS2 ec 3.2.1.21 BEN31_16625 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BEN31_16655 ENOG4108IMY Transcriptional regulator BEN31_16660 ENOG4105HDK L-asparaginase BEN31_16665 ENOG4108IJ0 Aspartate ammonia-lyase BEN31_16670 ENOG4105DFD Na H antiporter BEN31_16695 ENOG4105EMD TRANSCRIPTIONal BEN31_16700 ENOG4105CK1 PTS System BEN31_16710 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BEN31_16715 ENOG4105CS2 ec 3.2.1.21 BEN31_16720 ENOG4105VZJ PTS System BEN31_16725 ENOG4105VCP PTS System BEN31_16730 ENOG4107BJW polysaccharide deacetylase BEN31_16735 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BEN31_16740 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BEN31_16745 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BEN31_16750 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BEN31_16755 ENOG4105KVH Transcriptional regulator BEN31_16760 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BEN31_16765 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BEN31_16790 ENOG4105KFN sortase, SrtB family BEN31_16800 ENOG4105S6R Iron-hydroxamate transporter permease subunit BEN31_16810 ENOG4105C4M (Ubiquinol oxidase) subunit I BEN31_16815 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BEN31_16820 ENOG4108JJ9 ABC, transporter BEN31_16825 ENOG4108JJ8 (ABC) transporter BEN31_16830 ENOG4108J20 pectate lyase BEN31_16850 ENOG4107R37 Glutamate dehydrogenase BEN31_16865 ENOG4105EMD TRANSCRIPTIONal BEN31_16870 ENOG4105VZJ PTS System BEN31_16875 ENOG4105CK1 PTS System BEN31_16880 ENOG4105VCP PTS System BEN31_16885 ENOG4105F8D glycoside hydrolase family 4 BEN31_16900 ENOG4105CM2 brancheD-chain amino acid aminotransferase BEN31_16905 ENOG4108M26 parallel beta-helix repeat protein BEN31_16910 ENOG4108QGH periplasmic BEN31_16915 ENOG4105C2J ABC transporter BEN31_16920 ENOG4105CNN ABC, transporter BEN31_16935 ENOG4107R0W ABC transporter BEN31_16940 ENOG4105E5Q amino acid AbC transporter BEN31_16955 ENOG4105DR4 Methyltransferase BEN31_16960 ENOG41067MG lrgb family BEN31_16970 ENOG4105CMU LysR family (Transcriptional regulator BEN31_16975 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BEN31_16980 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BEN31_17015 ENOG4105WH5 Teichoic acid glycosylation protein BEN31_17030 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BEN31_17035 ENOG4105CMR udp-glucose 4-epimerase BEN31_17050 ENOG4105E2S oxidase) subunit II BEN31_17055 ENOG4105BZ9 Cytochrome C oxidase, subunit I BEN31_17060 ENOG4105CCU oxidase (Subunit III) BEN31_17065 ENOG41060D1 Quinol oxidase BEN31_17080 ENOG4108DBC nitroreductase BEN31_17085 ENOG4105DEN Luciferase family BEN31_17095 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BEN31_17110 ENOG4105C5Y PTS System BEN31_17130 ENOG4105DWF phosphomethylpyrimidine kinase BEN31_17140 ENOG4108RJ9 Glycosyl transferase, family 2 BEN31_17145 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BEN31_17150 ENOG4105C26 Dehydrogenase BEN31_17195 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BEN31_17200 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BEN31_17210 ENOG4107TY6 Acylneuraminate cytidylyltransferase BEN31_17215 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BEN31_17220 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BEN31_17225 ENOG4105C1B dTDP-glucose 4-6-dehydratase BEN31_17230 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BEN31_17235 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BEN31_17245 ENOG4105CHM Aminotransferase BEN31_17250 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase BEN31_17255 ENOG4105CHR reductase BEN31_17265 ENOG41061WN bacilysin biosynthesis protein BEN31_17270 ENOG4105FCW Major Facilitator superfamily BEN31_17280 ENOG4105F27 Major Facilitator BEN31_17285 ENOG4107JTW chlorite dismutase BEN31_17290 ENOG4108IJ2 phosphate acetyltransferase BEN31_17325 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BEN31_17335 ENOG4108VCI transcription factor, rsfa family BEN31_17340 ENOG4105QAT UPF0741 protein BEN31_17345 ENOG4105DCI Phosphohydrolase BEN31_17360 ENOG41069HH 4-oxalocrotonate tautomerase BEN31_17365 ENOG4108Z4T Peptidase M50 BEN31_17370 ENOG4108XFG YwhD family BEN31_17375 ENOG4105BZ4 penicillin-binding protein BEN31_17380 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BEN31_17385 ENOG4105CYW agmatinase BEN31_17395 ENOG410684U Domain of unknown function (DUF1934) BEN31_17400 ENOG4105C75 arginyL-tRNA synthetase BEN31_17410 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BEN31_17415 ENOG4105BZ1 (ABC) transporter BEN31_17420 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BEN31_17440 ENOG4105DF6 Fe-S oxidoreductase BEN31_17450 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BEN31_17455 ENOG4105C1G acyl-Coa dehydrogenase BEN31_17460 ENOG4105C1G acyl-Coa dehydrogenase BEN31_17475 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BEN31_17485 ENOG410812K response regulator receiver protein BEN31_17490 ENOG4105D2N Aldolase BEN31_17500 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BEN31_17505 ENOG4105CBT Fructose-1,6-bisphosphatase BEN31_17510 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BEN31_17515 ENOG41082DI 50s ribosomal protein l31 BEN31_17520 ENOG4107104 thymidine kinase BEN31_17525 ENOG4105C6K Malic enzyme BEN31_17530 ENOG4107TT2 Auxin Efflux Carrier BEN31_17540 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BEN31_17545 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BEN31_17555 ENOG4108ZXQ stage ii sporulation protein r BEN31_17565 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BEN31_17575 ENOG4107WAU Protein tyrosine phosphatase BEN31_17580 ENOG4108YZG isomerase BEN31_17585 ENOG4108UIC UPF0340 protein BEN31_17590 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BEN31_17595 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BEN31_17605 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BEN31_17625 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BEN31_17630 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BEN31_17635 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BEN31_17640 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BEN31_17650 ENOG4106778 Protein of unknown function (DUF1146) BEN31_17660 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BEN31_17675 ENOG4108TF4 von Willebrand factor, type A BEN31_17680 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit BEN31_17685 ENOG4105FCD Major Facilitator BEN31_17690 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BEN31_17700 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BEN31_17705 ENOG4105CKI cobalamin synthesis protein BEN31_17745 ENOG4107TCE N-acetyltransferase BEN31_17750 ENOG4105FRN stage II sporulation protein BEN31_17760 ENOG4105BZU Histidine kinase BEN31_17765 ENOG4105CDA abc transporter atp-binding protein BEN31_17770 ENOG4105E5Q amino acid AbC transporter BEN31_17775 ENOG4105EAB amino acid AbC transporter BEN31_17780 ENOG41080V3 Major Facilitator superfamily BEN31_17785 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BEN31_17790 ENOG4105CZM Major Facilitator BEN31_17795 ENOG4107MII Sugar-specific transcriptional regulator TrmB BEN31_17800 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BEN31_17805 ENOG4105DFF Rod shape-determining protein mreb BEN31_17815 ENOG4105CGA flagellar basal-body rod protein FlgG BEN31_17825 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BEN31_17830 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BEN31_17845 ENOG410667J hydrolase BEN31_17850 ENOG4105BZU Histidine kinase BEN31_17855 ENOG4105C0D helicase BEN31_17860 ENOG4105KBK Zinc finger, swim domain protein BEN31_17865 ENOG4105C6Y Udp-glucose 6-dehydrogenase BEN31_17870 ENOG4105FGV Chromate BEN31_17875 ENOG4105CAH Chromate BEN31_17885 ENOG4107FQX Alpha-acetolactate decarboxylase BEN31_17895 ENOG4107RSM transcriptional regulator BEN31_17900 ENOG4107XC4 flavin reductase domain protein, FMN-binding BEN31_17905 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BEN31_17910 ENOG4105CNN ABC, transporter BEN31_17915 ENOG4105C2J ABC transporter BEN31_17920 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BEN31_17925 ENOG4108RVA ribokinase BEN31_17930 ENOG4105ETE Transcriptional regulator (LacI family BEN31_17950 ENOG4105N98 Capsule biosynthesis protein capB BEN31_17960 ENOG4105PNM synthesis protein BEN31_17965 ENOG4105K4H Nlp p60 protein BEN31_17970 ENOG4105J7I hydrolase BEN31_17975 ENOG4108KGH TRANSCRIPTIONal BEN31_17980 ENOG4105C54 Major Facilitator superfamily BEN31_17985 ENOG4107RGC Glycosyl transferase, family 2 BEN31_17990 ENOG4108NHD germination protein BEN31_18005 ENOG4105CHR reductase BEN31_18010 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BEN31_18015 ENOG4108M60 Transcriptional regulator BEN31_18020 ENOG4105D7K pfkb domain protein BEN31_18025 ENOG4108UHU Aldolase BEN31_18030 ENOG4105I4A GCN5-related N-acetyltransferase BEN31_18040 ENOG4105C2F Histidine kinase BEN31_18045 ENOG4105WH1 Two component transcriptional regulator luxr family BEN31_18050 ENOG4108JP0 extracellular solute-binding protein family 1 BEN31_18055 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BEN31_18065 ENOG4105DG6 mannose-6-phosphate isomerase BEN31_18075 ENOG4107RZX Teichoic acid biosynthesis protein BEN31_18085 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BEN31_18090 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BEN31_18095 ENOG4107SJB teichoic acid biosynthesis BEN31_18100 ENOG4107VDP teichoic acid biosynthesis BEN31_18110 ENOG4105EY8 ABC transporter BEN31_18120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BEN31_18125 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BEN31_18160 ENOG4108KGH TRANSCRIPTIONal BEN31_18170 ENOG4105JFG SpoIID LytB domain protein BEN31_18175 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BEN31_18185 ENOG4105D3Q Sugar transferase BEN31_18190 ENOG4105PSV Polysaccharide Biosynthesis Protein BEN31_18195 ENOG4107RA4 Glycosyl transferase (Group 1 BEN31_18200 ENOG4105C6Y Udp-glucose 6-dehydrogenase BEN31_18205 ENOG4105C1B dTDP-glucose 4-6-dehydratase BEN31_18210 ENOG4105QZI O-Antigen Polymerase BEN31_18225 ENOG4107EF8 Glycosyl transferase (Group 1 BEN31_18230 ENOG4105ESV Glycosyl transferase, family 4 BEN31_18235 ENOG4108KGH TRANSCRIPTIONal BEN31_18240 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BEN31_18245 ENOG4105BZU Histidine kinase BEN31_18250 ENOG4105WH1 Two component transcriptional regulator luxr family BEN31_18270 ENOG41081UC Inherit from COG: Competence protein BEN31_18275 ENOG4105RU3 BEN31_18290 ENOG4105E1Q flagellar hook-associated protein BEN31_18295 ENOG4105DTJ flagellar hook-associated protein BEN31_18300 ENOG4105MKD BEN31_18305 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BEN31_18310 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BEN31_18315 ENOG41083S7 flagellar protein FlaG BEN31_18320 ENOG4107RT6 flagellar hook-associated BEN31_18325 ENOG4105MQ3 flagellar protein FliS BEN31_18340 ENOG4105C8Q Methyl-accepting chemotaxis BEN31_18345 ENOG4105MS2 ribosomal subunit Interface protein BEN31_18355 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BEN31_18380 ENOG4105CAK Cell division ATP-binding protein ftsE BEN31_18385 ENOG4105CRP Part of the ABC transporter FtsEX involved in BEN31_18400 ENOG4105CN1 protease BEN31_18415 ENOG4105KVH Transcriptional regulator BEN31_18420 ENOG4108RCM Nitroreductase BEN31_18430 ENOG4105BZU Histidine kinase BEN31_18435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BEN31_18450 ENOG4105MKU Transcriptional regulator BEN31_18470 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BEN31_18475 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BEN31_18490 ENOG4108PY7 BEN31_18495 ENOG41067S9 phage shock protein C, PspC BEN31_18500 ENOG41086DT Membrane protein of unknown function BEN31_18505 ENOG41088CQ domain protein BEN31_18510 ENOG4105FDP GntR family transcriptional regulator BEN31_18515 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BEN31_18520 ENOG4105CE4 GlcNAc 6-P deacetylase BEN31_18525 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BEN31_18535 ENOG4105HKU nucleoside recognition domain-containing protein BEN31_18540 ENOG4107XGZ Hydrolase BEN31_18545 ENOG4108S4C acetyltransferase BEN31_18550 ENOG4108Z40 Transcriptional regulator BEN31_18555 ENOG4108RYK Nad-dependent epimerase dehydratase BEN31_18565 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BEN31_18570 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BEN31_18575 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BEN31_18580 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BEN31_18585 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BEN31_18590 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BEN31_18595 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BEN31_18600 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BEN31_18615 ENOG4105C3M thioredoxin reductase BEN31_18620 ENOG4108Z4K mutator MutT protein BEN31_18625 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BEN31_18630 ENOG4105CHW UPF0052 protein BEN31_18635 ENOG4105CIE May be required for sporulation (By similarity) BEN31_18640 ENOG4105KRI phosphocarrier protein (HPr BEN31_18645 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BEN31_18655 ENOG4105C5I Dehydrogenase BEN31_18660 ENOG4108V2W Carbonate dehydratase BEN31_18665 ENOG4105CHH sulfate transporter BEN31_18670 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BEN31_18675 ENOG4108URH decarboxylase BEN31_18680 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BEN31_18690 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)