locus-tag class description BPUM_0001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BPUM_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BPUM_0003 ENOG410848D S4 domain protein YaaA BPUM_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BPUM_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BPUM_0007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BPUM_0010 ENOG4105CDW Resistance protein BPUM_0011 ENOG4105CXN decarboxylase BPUM_0012 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BPUM_0013 ENOG4105X0R protein from nitrogen regulatory protein P-II BPUM_0014 ENOG4105XVJ Protein of unknown function (DUF327) BPUM_0015 ENOG4105FA2 dna polymerase iii BPUM_0016 ENOG4105MA4 psp1 domain protein BPUM_0017 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) BPUM_0018 ENOG41060K3 Methyltransferase BPUM_0019 ENOG4105VC4 domain protein BPUM_0020 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BPUM_0021 ENOG4105KRN Transcriptional regulator, abrb family BPUM_0022 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BPUM_0023 ENOG4105F8V Hydrolase, tatD family BPUM_0024 ENOG41069ER domain protein BPUM_0026 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BPUM_0027 ENOG4105XFA sporulation peptidase YabG BPUM_0028 ENOG4105W42 Veg protein BPUM_0029 ENOG4105XEW small acid-soluble spore protein BPUM_0030 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BPUM_0031 ENOG4105DFT pur operon repressor BPUM_0032 ENOG4105KME endoribonuclease L-psp BPUM_0034 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BPUM_0035 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BPUM_0036 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BPUM_0037 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BPUM_0039 ENOG4108JA2 transcriptioN-repair coupling factor BPUM_0040 ENOG4108M14 stage v sporulation protein t BPUM_0042 ENOG4108IY2 MazG family BPUM_0043 ENOG41082I2 s4 domain protein BPUM_0044 ENOG4105VYY sporulation protein yabp BPUM_0047 ENOG41060GV RNA binding s1 domain protein BPUM_0051 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BPUM_0052 ENOG4108UGV hypoxanthine phosphoribosyltransferase BPUM_0053 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BPUM_0054 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BPUM_0055 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BPUM_0056 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BPUM_0057 ENOG4105C6T cysteine synthase BPUM_0058 ENOG4105CRQ synthase (Component I) BPUM_0059 ENOG4105DDQ anthranilate synthase BPUM_0060 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BPUM_0061 ENOG4105EEI dihydropteroate synthase BPUM_0062 ENOG4105KRF dihydroneopterin aldolase BPUM_0063 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BPUM_0065 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BPUM_0066 ENOG4105CRK lysyL-tRNA synthetase BPUM_0069 ENOG4108Z0C Uvrb UvrC protein BPUM_0070 ENOG41066A3 ATP guanido phosphotransferase BPUM_0072 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BPUM_0073 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BPUM_0074 ENOG4105CTP PilT protein domain protein BPUM_0075 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BPUM_0076 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BPUM_0077 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BPUM_0078 ENOG4105D7W serine acetyltransferase BPUM_0079 ENOG4105C8N cysteinyl-tRNA synthetase BPUM_0080 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BPUM_0081 ENOG4105C2N RNA methyltransferase TrmH family group 3 BPUM_0082 ENOG4105M0M Tetracycline resistance protein BPUM_0086 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BPUM_0087 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BPUM_0088 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BPUM_0089 ENOG4108VZM 50s ribosomal protein L10 BPUM_0090 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BPUM_0091 ENOG4107Y49 methyltransferase BPUM_0093 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BPUM_0094 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BPUM_0095 ENOG4105XPM ribosomal protein BPUM_0096 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BPUM_0097 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BPUM_0098 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BPUM_0100 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BPUM_0101 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BPUM_0102 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BPUM_0103 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BPUM_0104 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BPUM_0105 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BPUM_0106 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BPUM_0107 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BPUM_0108 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BPUM_0109 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BPUM_0110 ENOG41082SA 50s ribosomal protein l29 BPUM_0111 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BPUM_0112 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BPUM_0113 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BPUM_0114 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BPUM_0115 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BPUM_0116 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BPUM_0117 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BPUM_0118 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BPUM_0119 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BPUM_0120 ENOG4105VPB 50S ribosomal protein L30 BPUM_0121 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BPUM_0122 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BPUM_0123 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BPUM_0124 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BPUM_0126 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BPUM_0128 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BPUM_0129 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BPUM_0130 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BPUM_0131 ENOG4108ZT0 50S ribosomal protein l17 BPUM_0132 ENOG4108JJB ABC transporter BPUM_0133 ENOG4108JJB ABC transporter BPUM_0134 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BPUM_0135 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BPUM_0136 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BPUM_0137 ENOG4108UJD 30S ribosomal protein S9 BPUM_0145 ENOG4105D1F ATP-binding protein BPUM_0148 ENOG4108NMV polysaccharide deacetylase BPUM_0150 ENOG4105I03 Flagellin BPUM_0151 ENOG4105CHH sulfate transporter BPUM_0153 ENOG4105EHZ conserved protein UCP016719 BPUM_0154 ENOG4105D17 glycoside hydrolase, family 3 domain protein BPUM_0158 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BPUM_0160 ENOG4105EMN RNA polymerase sigma factor BPUM_0162 ENOG4105C8B TIGR00159 family BPUM_0163 ENOG4107U5W ybbr family BPUM_0164 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BPUM_0165 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BPUM_0169 ENOG4105DA5 (ABC) transporter BPUM_0177 ENOG4105VZ8 Transcriptional regulator BPUM_0181 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BPUM_0182 ENOG4105CXY transporter BPUM_0184 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BPUM_0186 ENOG4105C7Z Conserved Protein BPUM_0189 ENOG4105XTG Pfam:DUF156 BPUM_0190 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BPUM_0191 ENOG4105WZW rhodanese family BPUM_0192 ENOG4105VFE sira family BPUM_0193 ENOG4107TPS domain protein BPUM_0194 ENOG4105VFE sira family BPUM_0195 ENOG41087NI Sulfite exporter TauE/SafE BPUM_0197 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BPUM_0198 ENOG4108SUT Major Facilitator Superfamily BPUM_0202 ENOG4105EWC Purine nucleoside phosphorylase BPUM_0204 ENOG4107SCQ Iron-containing alcohol dehydrogenase BPUM_0205 ENOG4105C72 UPF0176 protein BPUM_0206 ENOG4107QTZ amino acid BPUM_0208 ENOG4105CID antiterminator BPUM_0209 ENOG4105C5Y PTS System BPUM_0210 ENOG4105CS2 ec 3.2.1.21 BPUM_0214 ENOG4105EMD TRANSCRIPTIONal BPUM_0215 ENOG4105EVU fructokinase BPUM_0216 ENOG4105C8I hydrolase, family 38 BPUM_0217 ENOG4105DM4 PTS System BPUM_0218 ENOG4108YRF PTS System BPUM_0219 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BPUM_0220 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BPUM_0223 ENOG4108IQI permease BPUM_0224 ENOG4108J5H Homocysteine s-methyltransferase BPUM_0229 ENOG4105C2C drug resistance transporter, Bcr CflA BPUM_0233 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BPUM_0235 ENOG4105J7D transcriptional regulator BPUM_0237 ENOG4105E2A Dehydrogenase BPUM_0238 ENOG41067TZ transcriptional regulator, MarR family BPUM_0240 ENOG4105CUB amino acid BPUM_0242 ENOG4105D74 hydrolase BPUM_0244 ENOG4105CSV Glutaminase BPUM_0247 ENOG41060AI SEC-C motif BPUM_0249 ENOG4107SET aldo keto reductase BPUM_0251 ENOG4107Y7X LytTR BPUM_0252 ENOG4108IUW ABC transporter BPUM_0253 ENOG4108SDH ABC, transporter BPUM_0257 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BPUM_0259 ENOG4105DEN Luciferase family BPUM_0260 ENOG4108N0M stress protein BPUM_0261 ENOG4106FN3 tellurium resistance protein BPUM_0262 ENOG4106FN3 tellurium resistance protein BPUM_0263 ENOG4107TS3 membrane protein, TerC BPUM_0268 ENOG4108TTB tellurium resistance protein BPUM_0270 ENOG4108IJ7 Glycine betaine BPUM_0271 ENOG4107SQ8 Glycine betaine BPUM_0277 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BPUM_0281 ENOG4105TRI Hydrolase BPUM_0288 ENOG4105EIG urea carboxylase-associated protein 1 BPUM_0289 ENOG4107RMH nh(3)-dependent nad( ) synthetase BPUM_0290 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BPUM_0291 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BPUM_0293 ENOG41079KZ Major Facilitator Superfamily BPUM_0295 ENOG4105C5Q Transcriptional regulator BPUM_0296 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BPUM_0297 ENOG4105I82 acetyl xylan esterase BPUM_0299 ENOG410756H nucleotidyltransferase BPUM_0301 ENOG4105C26 Dehydrogenase BPUM_0302 ENOG4107YHD transcriptional regulator BPUM_0303 ENOG4107R5R arsenical pump membrane protein BPUM_0304 ENOG4105E5Q amino acid AbC transporter BPUM_0305 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BPUM_0307 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BPUM_0309 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BPUM_0311 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_0317 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BPUM_0318 ENOG4105F38 ABC transporter, permease BPUM_0319 ENOG4105CEY Amp-dependent synthetase and ligase BPUM_0325 ENOG4105SX7 Transporter BPUM_0337 ENOG4105C19 ABC transporter BPUM_0338 ENOG4105CDA abc transporter atp-binding protein BPUM_0339 ENOG4105DRP amino acid AbC transporter BPUM_0343 ENOG4105DUX Transporter BPUM_0345 ENOG4105CPU Monooxygenase BPUM_0346 ENOG4108XSB acetyltransferase, (GNAT) family BPUM_0347 ENOG4105EAB amino acid AbC transporter BPUM_0348 ENOG4108HW4 amino acid AbC transporter BPUM_0350 ENOG4105CH2 amidohydrolase BPUM_0351 ENOG4108PGP mmge prpd family protein BPUM_0353 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BPUM_0354 ENOG4105BZU Histidine kinase BPUM_0356 ENOG4105CFH Aspartokinase BPUM_0358 ENOG4105R8C Transcriptional regulator BPUM_0360 ENOG4105YVS arsR family transcriptional regulator BPUM_0362 ENOG4108JPW Aminotransferase BPUM_0363 ENOG4107QTZ amino acid BPUM_0364 ENOG4105C26 Dehydrogenase BPUM_0365 ENOG4105DYS nad(p)h dehydrogenase (quinone) BPUM_0367 ENOG4105KTB nuclear export factor GLE1 BPUM_0368 ENOG4108T5E Copper resistance protein BPUM_0371 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BPUM_0372 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_0377 ENOG4105X3H Excalibur domain protein BPUM_0379 ENOG4105E7W lamb ycsf family protein BPUM_0380 ENOG4105C5A transporter BPUM_0381 ENOG4105CFM UPF0317 protein BPUM_0382 ENOG4105P4J Allophanate hydrolase, subunit 1 BPUM_0384 ENOG4107258 Transcriptional regulator BPUM_0385 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BPUM_0386 ENOG4105XJB lipolytic protein G-D-S-L family BPUM_0388 ENOG4105ETD TRANSCRIPTIONal BPUM_0389 ENOG4105HMZ Methyltransferase BPUM_0390 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BPUM_0391 ENOG410606W general stress protein BPUM_03955 ENOG4108RYM conjugative transposon protein BPUM_0396 ENOG4105VCH membrane BPUM_0397 ENOG4105DRR Transcriptional regulator, GntR family BPUM_0398 ENOG410631K Membrane BPUM_0399 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BPUM_0400 ENOG4105C9U ATP-dependent DNA helicase RecQ BPUM_0403 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BPUM_0404 ENOG4107R8N Glycosyl transferase, family 2 BPUM_0406 ENOG4105C0X amino acid BPUM_0413 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BPUM_0414 ENOG4107BMA Transglycosylase associated protein BPUM_0415 ENOG4105EU9 BPUM_0416 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BPUM_04165 ENOG4105CB2 alcohol dehydrogenase BPUM_0417 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BPUM_0418 ENOG4108MRH transcriptional regulatory protein BPUM_04185 ENOG4107YR5 Diacylglycerol kinase BPUM_0419 ENOG4107QJT sodium dicarboxylate symporter BPUM_0420 ENOG4106F5Q Membrane BPUM_0422 ENOG4105CJ1 ABC, transporter BPUM_0426 ENOG4105SZ6 Thioredoxin BPUM_0427 ENOG4105CPF Cell wall formation (By similarity) BPUM_0428 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BPUM_0431 ENOG4105C1J atp-dependent rna helicase BPUM_0432 ENOG410905X membrane-flanked domain protein BPUM_0433 ENOG4105CKV Membrane BPUM_04335 ENOG41081UC Inherit from COG: Competence protein BPUM_04355 ENOG4105E5Q amino acid AbC transporter BPUM_0436 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BPUM_04360 ENOG4107R0W ABC transporter BPUM_04365 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BPUM_0437 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BPUM_0439 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BPUM_0440 ENOG4107MMM Anti-sigma-factor antagonist BPUM_0441 ENOG4105FUA antagonist BPUM_0442 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BPUM_0443 ENOG4107SGM protein serine threonine phosphatase BPUM_0444 ENOG4105WN5 stage II sporulation protein BPUM_0445 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BPUM_0447 ENOG41064BQ Phosphatase BPUM_0451 ENOG4107RUY (E1 component), alpha subunit BPUM_0453 ENOG4107QKR Dehydrogenase BPUM_0455 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BPUM_0458 ENOG4105RHY Pfam:UPF0157 BPUM_0459 ENOG4105VEQ Cold shock protein BPUM_0460 ENOG4108VJ1 Transcriptional regulator (CarD family BPUM_0461 ENOG4105DQ4 alcohol dehydrogenase BPUM_0462 ENOG4105VUF Transcriptional regulator BPUM_0465 ENOG4105C0R drug resistance transporter emrb qaca subfamily BPUM_0470 ENOG4107RB3 L-asparaginase BPUM_0474 ENOG4108IG5 Transcriptional regulator BPUM_0481 ENOG4105VDT -acetyltransferase BPUM_0482 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BPUM_0484 ENOG4105ST3 Transcriptional regulator BPUM_0485 ENOG4105NAE bifunctional deaminase-reductase domain protein BPUM_0486 ENOG41090MY MarR family Transcriptional regulator BPUM_0487 ENOG4108TVJ Nitroreductase BPUM_0491 ENOG4108JCI Transcriptional regulator BPUM_0493 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BPUM_0494 ENOG4106NZI LysR family Transcriptional regulator BPUM_0495 ENOG4105CPC Aldo Keto reductase BPUM_0499 ENOG4108UMN azlc family BPUM_0504 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BPUM_0506 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BPUM_0507 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BPUM_0508 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BPUM_0509 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BPUM_0510 ENOG4105FKZ Methyl-accepting chemotaxis BPUM_0511 ENOG4105ZMH deoxynucleoside kinase BPUM_0513 ENOG4105VRS hydrolase family 18 BPUM_0514 ENOG4105GTG Isochorismatase BPUM_0515 ENOG4108Z6B deaminase BPUM_0516 ENOG4105C6E dna polymerase iii BPUM_0517 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BPUM_0518 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BPUM_0520 ENOG41067KS pro-sigma K processing BPUM_0521 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BPUM_0522 ENOG4105K8N protein family UPF0079, ATPase BPUM_0523 ENOG41072GX Peptidase M22 Glycoprotease BPUM_0524 ENOG410801F ribosomal-protein-alanine acetyltransferase BPUM_0525 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BPUM_0526 ENOG4105C5H ABC transporter BPUM_0527 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BPUM_0528 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BPUM_0529 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BPUM_0530 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BPUM_0531 ENOG41081VB Hydrolase BPUM_0533 ENOG4108TYN CAAX amino terminal protease family protein BPUM_0534 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BPUM_0535 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BPUM_0542 ENOG4107STQ Multicopper oxidase BPUM_0543 ENOG4105C85 amino acid BPUM_0545 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BPUM_0548 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BPUM_0554 ENOG4106BHR ftsk SpoIIIE family protein BPUM_0555 ENOG4106128 DNA-binding helix-turn-helix protein BPUM_0576 ENOG4105K4H Nlp p60 protein BPUM_0582 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BPUM_0586 ENOG4105KNA -acetyltransferase BPUM_0588 ENOG4105JVQ RNA Polymerase BPUM_0590 ENOG4108RWP Major Facilitator Superfamily protein BPUM_0591 ENOG4105GZI Transcriptional regulator BPUM_0592 ENOG4105C7N Xanthine uracil vitamin C permease BPUM_0594 ENOG4108U5N UPF0316 protein BPUM_0596 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BPUM_0597 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BPUM_0598 ENOG4105C83 adenylosuccinate lyase BPUM_0599 ENOG4105C8V SAICAR synthetase BPUM_0600 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BPUM_0602 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BPUM_0604 ENOG4105CXB phosphoribosylaminoimidazole synthetase BPUM_0605 ENOG4108V3E phosphoribosylglycinamide formyltransferase BPUM_0606 ENOG4105DC1 bifunctional purine biosynthesis protein purh BPUM_0607 ENOG4105C12 Phosphoribosylglycinamide synthetase BPUM_0612 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BPUM_0615 ENOG4107S4Y M20 DapE family protein YgeY BPUM_0619 ENOG4105KGF protein, YerC YecD BPUM_0621 ENOG4105CBC glutamate synthase BPUM_0624 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BPUM_0625 ENOG4105C4R Atp-dependent dna helicase BPUM_0626 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BPUM_0632 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BPUM_0635 ENOG4105C1G acyl-Coa dehydrogenase BPUM_0638 ENOG4107SQU synthase BPUM_0640 ENOG4105CRN Aminoglycoside phosphotransferase BPUM_0641 ENOG4105G6Z alkaline phosphatase BPUM_0642 ENOG4105KT7 mgtC SapB transporter BPUM_0643 ENOG4105CK7 Sodium proline symporter BPUM_0644 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BPUM_0645 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BPUM_0646 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BPUM_0647 ENOG4108IG5 Transcriptional regulator BPUM_0649 ENOG4105DU0 nucleoside hydrolase BPUM_0650 ENOG4105CBD Diacylglycerol kinase BPUM_0651 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BPUM_0652 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BPUM_0659 ENOG4108Q3X Transcriptional regulator BPUM_0660 ENOG4105CI1 PTS System BPUM_0661 ENOG4105F8D glycoside hydrolase family 4 BPUM_0663 ENOG41062ES Transcriptional regulator BPUM_0664 ENOG4105C3M thioredoxin reductase BPUM_0667 ENOG4105F8D glycoside hydrolase family 4 BPUM_0668 ENOG4105HX0 Transcriptional regulator BPUM_0674 ENOG4108R1P BPUM_0676 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BPUM_0678 ENOG41090R9 glycosyltransferase BPUM_0679 ENOG4107R51 Glycosyl transferase, family 2 BPUM_0680 ENOG41090R9 glycosyltransferase BPUM_0681 ENOG4105EU0 Major facilitator Superfamily BPUM_0683 ENOG4107RVG penicillin-binding protein BPUM_0684 ENOG4105C8P )-transporter BPUM_0689 ENOG4105CUB amino acid BPUM_0690 ENOG4107TVC Glycosyl transferase, family 2 BPUM_0691 ENOG4105C5H ABC transporter BPUM_0692 ENOG4107SWG transcriptional regulator MERR family BPUM_0693 ENOG4105DXB Major Facilitator superfamily BPUM_0694 ENOG4105C5H ABC transporter BPUM_0695 ENOG4105FDU atp-dependent rna helicase BPUM_0696 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BPUM_0700 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BPUM_0701 ENOG4105E6M Sulphatase-modifying factor protein BPUM_0703 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BPUM_0708 ENOG4108MRH transcriptional regulatory protein BPUM_0712 ENOG4105PY6 Phenolic acid decarboxylase BPUM_0713 ENOG4105U3E Transcriptional regulator BPUM_0715 ENOG41084AG Acylphosphatase BPUM_0716 ENOG4108RPX mosc domain containing protein BPUM_0719 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BPUM_0721 ENOG4105NX3 Membrane BPUM_0725 ENOG4105DY8 decarboxylase BPUM_0728 ENOG4105C5Y PTS System BPUM_0729 ENOG4105CG3 alpha amylase, catalytic region BPUM_0730 ENOG4107414 GntR family transcriptional regulator BPUM_0732 ENOG4105CGH 5'-nucleotidase BPUM_0733 ENOG4107RKG DJ-1/PfpI family BPUM_0735 ENOG4105BZG amino acid carrier protein BPUM_0736 ENOG4105KJF protein tyrosine phosphatase BPUM_0738 ENOG4107U9T Pfam:Ribonuclease_BN BPUM_0739 ENOG4108ISG Major Facilitator BPUM_0741 ENOG4105UPD Calcium Proton BPUM_0743 ENOG4105CDY transcriptional regulatory protein BPUM_0745 ENOG4105D8X mechanosensitive ion channel BPUM_0750 ENOG4105D7N magnesium and cobalt transport protein CorA BPUM_0753 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BPUM_0754 ENOG4108IG5 Transcriptional regulator BPUM_0755 ENOG4107P5I polyketide synthase BPUM_0758 ENOG4107TXC Transcriptional regulator BPUM_0759 ENOG4108RWP Major Facilitator Superfamily protein BPUM_0761 ENOG4105C22 threonyL-tRNA synthetase BPUM_0771 ENOG4105KPY Small multidrug resistance protein BPUM_0772 ENOG410839T multidrug resistance protein BPUM_0776 ENOG4107TDE lipolytic protein G-D-S-L family BPUM_0780 ENOG4105K6V RNA polymerase BPUM_0784 ENOG4108YYS metal-dependent hydrolase (By similarity) BPUM_0786 ENOG410834F Transcriptional regulator BPUM_0791 ENOG4107Y03 Nitroreductase BPUM_0794 ENOG4105ECP epimerase BPUM_0795 ENOG4105KC9 Modulates RecA activity (By similarity) BPUM_0800 ENOG4105CKK Glycosyl transferase, family 2 BPUM_0801 ENOG4105EJV Membrane BPUM_0805 ENOG4105F0F Oxalate decarboxylase BPUM_0807 ENOG4106DF4 Sigma-70, region 4 BPUM_0809 ENOG41067AE Membrane-bound metal-dependent hydrolase BPUM_0810 ENOG4105CEN a g-specific adenine glycosylase BPUM_0811 ENOG4106BXE BPUM_0812 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BPUM_0817 ENOG4105EVI UPF0374 protein BPUM_0818 ENOG4105BZ1 (ABC) transporter BPUM_0819 ENOG4105C3U ABC transporter BPUM_0820 ENOG4108JQ7 (ABC) transporter BPUM_0821 ENOG4105DEF Extracellular solute-binding protein, family 5 BPUM_0822 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BPUM_0823 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BPUM_0824 ENOG4107NBY Membrane BPUM_0825 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BPUM_0826 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BPUM_0827 ENOG4105G5W regulator Fur family BPUM_0839 ENOG4105E0M Sulfatase BPUM_0843 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BPUM_0845 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BPUM_0851 ENOG4105CJ1 ABC, transporter BPUM_0856 ENOG4105CYN Serine protein kinase BPUM_0857 ENOG4106AKX UPF0229 protein BPUM_0858 ENOG4105CW7 secretion protein, HlyD family BPUM_0859 ENOG4105C0R drug resistance transporter emrb qaca subfamily BPUM_0860 ENOG4105CS1 NAD(P)H quinone oxidoreductase BPUM_0862 ENOG4105VEQ Cold shock protein BPUM_0863 ENOG4105BZU Histidine kinase BPUM_0869 ENOG4105BZU Histidine kinase BPUM_0872 ENOG4108YBP pseudouridine synthase BPUM_0875 ENOG4107YBY Hydrolase BPUM_0876 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BPUM_0879 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BPUM_0880 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BPUM_0881 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BPUM_0883 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BPUM_0884 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BPUM_0886 ENOG4105BZU Histidine kinase BPUM_0887 ENOG4105WH1 Two component transcriptional regulator luxr family BPUM_0892 ENOG4105CH6 catalase BPUM_0893 ENOG4105KPV Transcriptional regulator BPUM_0894 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BPUM_0895 ENOG4105ED1 spovr family BPUM_0896 ENOG4105G6Z alkaline phosphatase BPUM_0899 ENOG4105DQ6 Transposase BPUM_0901 ENOG4105J37 BPUM_0902 ENOG4108AEY RNA polymerase sigma factor BPUM_0903 ENOG4105F6E Acyl-transferase BPUM_0904 ENOG4105C37 (CBS) domain BPUM_0906 ENOG4105C37 (CBS) domain BPUM_0908 ENOG4106A8V Protein CrcB homolog BPUM_0909 ENOG4105WMR Protein CrcB homolog BPUM_0910 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BPUM_0913 ENOG4105D64 Mechanosensitive ion channel BPUM_0914 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BPUM_0915 ENOG4107VMI polysaccharide deacetylase BPUM_0916 ENOG4105F0I Aminotransferase BPUM_0918 ENOG4105BZ1 (ABC) transporter BPUM_0919 ENOG4105BZ1 (ABC) transporter BPUM_0925 ENOG410839P BPUM_0927 ENOG4108UH6 UPF0754 membrane protein BPUM_0928 ENOG4105WZB UPF0342 protein BPUM_0930 ENOG4105D4P Coproporphyrinogen iii oxidase BPUM_0932 ENOG4105CGU Enoyl-CoA hydratase BPUM_0934 ENOG4107VRP DNA repair exonuclease BPUM_0935 ENOG4106D4I domain protein BPUM_0938 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BPUM_0947 ENOG4105NBU tryptophan transport protein BPUM_0948 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BPUM_0949 ENOG4105K59 histidine triad (HIT) protein BPUM_0956 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BPUM_0957 ENOG4105BZ4 penicillin-binding protein BPUM_0958 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BPUM_0959 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BPUM_0960 ENOG4105C1Q protoporphyrinogen oxidase BPUM_0962 ENOG4105ECB domain protein BPUM_0963 ENOG4105DER m42 family BPUM_0966 ENOG4106AXD BPUM_0967 ENOG4108RQ5 Beta-lactamase domain-containing protein BPUM_0968 ENOG4105DF9 Lipoate-protein, ligase BPUM_0969 ENOG4105CEY Amp-dependent synthetase and ligase BPUM_0971 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BPUM_0972 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BPUM_0973 ENOG4107TB6 phosphoglycerate mutase BPUM_0974 ENOG4106YBV Methyl-accepting chemotaxis BPUM_0978 ENOG4105XVF Competence transcription factor BPUM_0981 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BPUM_0982 ENOG4105E5M Multidrug resistance protein D BPUM_0983 ENOG41067XF inhibitor BPUM_0984 ENOG4105DHS permease protein BPUM_0985 ENOG4105CM4 permease protein BPUM_0986 ENOG4108IPW abc transporter atp-binding protein BPUM_0988 ENOG4108KGH TRANSCRIPTIONal BPUM_0989 ENOG41060YP BPUM_0991 ENOG4108KK1 membrane protein AbrB duplication BPUM_0992 ENOG4105D0M Protease HtpX homolog BPUM_0994 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BPUM_0996 ENOG4105EYH Exonuclease BPUM_1007 ENOG4105ERH Fumarylacetoacetate hydrolase BPUM_1008 ENOG4106BKT UPF0344 protein BPUM_1010 ENOG4105CAQ asparagine synthetase BPUM_1013 ENOG4105UQX Mate efflux family protein BPUM_1014 ENOG4106HBX Transcriptional Regulator AraC Family BPUM_1020 ENOG4105DY8 decarboxylase BPUM_1028 ENOG4108VPT UPF0234 protein BPUM_1029 ENOG4105QNR S1 RNA binding domain protein BPUM_1030 ENOG4105DIH basic membrane BPUM_1031 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_1032 ENOG4105EPR degv family BPUM_1033 ENOG4107AYK membrAne BPUM_1035 ENOG41073B9 BPUM_1037 ENOG4108KP7 hydrolase BPUM_1038 ENOG4108MXZ Esterase BPUM_1039 ENOG4105VG1 fes assembly suf system protein BPUM_1040 ENOG4105IQ5 FAD linked oxidase domain protein BPUM_1042 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BPUM_1044 ENOG4105CAS nag kinase BPUM_1045 ENOG4105C8Y Acetylornithine aminotransferase BPUM_1046 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BPUM_1048 ENOG4105DBV ornithine carbamoyltransferase BPUM_1054 ENOG4107RMD Basic membrane lipoprotein BPUM_1057 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BPUM_1058 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BPUM_1060 ENOG4105C3U ABC transporter BPUM_1061 ENOG4108JQ7 (ABC) transporter BPUM_1064 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BPUM_1068 ENOG4105C31 Tryptophanyl-tRNA synthetase BPUM_1071 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BPUM_1072 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BPUM_1074 ENOG4108JQ7 (ABC) transporter BPUM_1077 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BPUM_1078 ENOG4108ZCF integral membrane protein BPUM_1079 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BPUM_1080 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BPUM_1082 ENOG4105DPN Oligoendopeptidase f BPUM_1084 ENOG4105T58 Dithiol-disulfide isomerase BPUM_1085 ENOG4108Z18 K06886 hemoglobin BPUM_1086 ENOG4105E4C Lytic transglycosylase catalytic BPUM_1087 ENOG4105MIX Adenylate cyclase BPUM_1088 ENOG4106EFP UPF0738 protein BPUM_1090 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BPUM_1091 ENOG4105EMS pseudouridine synthase BPUM_1092 ENOG4107S1Q Phosphatase BPUM_1094 ENOG4105ETU transcriptional activator (TenA BPUM_1095 ENOG4108VEU Thiamine monophosphate synthase BPUM_1098 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BPUM_1099 ENOG4105D06 uba thif-type nad fad binding protein BPUM_1100 ENOG4105DWF phosphomethylpyrimidine kinase BPUM_1101 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BPUM_1102 ENOG4107A88 BPUM_1114 ENOG4105ENA helicase BPUM_1119 ENOG4105C28 cystathionine BPUM_1120 ENOG4105C28 cystathionine BPUM_1122 ENOG4105KVH Transcriptional regulator BPUM_1125 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BPUM_1135 ENOG4105DUM transcriptional regulator, lysR family BPUM_1138 ENOG4107V2S Transcriptional regulator BPUM_1139 ENOG4105DJ2 Major Facilitator Superfamily BPUM_1146 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BPUM_1149 ENOG4105I03 Flagellin BPUM_1150 ENOG4105I03 Flagellin BPUM_1151 ENOG4105I03 Flagellin BPUM_1152 ENOG4105I03 Flagellin BPUM_1156 ENOG4105K7W phage-related replication protein BPUM_1157 ENOG410635T phage-like element pbsx protein BPUM_1158 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BPUM_1161 ENOG4105CJ3 phosphate transporter BPUM_1162 ENOG4107GRR phosphate transport regulator BPUM_1164 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BPUM_1167 ENOG4105DT3 PTS system, galactitol-specific IIc component BPUM_1170 ENOG4105CPQ Dehydrogenase BPUM_1171 ENOG4107RUY (E1 component), alpha subunit BPUM_1172 ENOG4105CPP Dehydrogenase, E1 component BPUM_1173 ENOG4105C7S Dehydrogenase BPUM_1175 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BPUM_1176 ENOG4105CHR reductase BPUM_1177 ENOG4107RHR regulatoR BPUM_1179 ENOG4107R7I amino acid BPUM_1181 ENOG4105C0H protease BPUM_1184 ENOG4108ME1 Peptidase M55 D-aminopeptidase BPUM_1185 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BPUM_1186 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BPUM_1187 ENOG4105C3U ABC transporter BPUM_1189 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BPUM_1190 ENOG4105DTQ mandelate racemase muconate lactonizing BPUM_1191 ENOG4107SN7 NLP P60 protein BPUM_1192 ENOG4108JQ7 (ABC) transporter BPUM_1193 ENOG4107TUM Amidinotransferase BPUM_1194 ENOG4108S4H thioesterase Superfamily protein BPUM_1195 ENOG4105K7K Transcriptional regulator BPUM_1199 ENOG4108428 Inherit from COG: -acetyltransferase BPUM_1200 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BPUM_1202 ENOG410839T multidrug resistance protein BPUM_1203 ENOG41080TC multidrug resistance protein BPUM_1205 ENOG4105CIY formyltetrahydrofolate deformylase BPUM_1207 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BPUM_1212 ENOG4105K56 Transcriptional regulator BPUM_1213 ENOG4108ZHJ Organic hydroperoxide resistance protein BPUM_1214 ENOG4107Y2X deaminase BPUM_1215 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BPUM_1217 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BPUM_1219 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BPUM_1220 ENOG41062D9 Histidine kinase BPUM_1222 ENOG4106849 propeptide, pepSY amd peptidase M4 BPUM_1225 ENOG4105CJW magnesium transporter BPUM_1230 ENOG4105V75 Transcriptional regulator BPUM_1234 ENOG4105BZU Histidine kinase BPUM_1235 ENOG4107T5V SNARE associated Golgi BPUM_1236 ENOG4107TS3 membrane protein, TerC BPUM_1237 ENOG4108WZW RNA polymerase sigma BPUM_1239 ENOG410681C small acid-soluble spore protein BPUM_1241 ENOG4105D0M Protease HtpX homolog BPUM_1243 ENOG410900G Protein of unknown function (DUF421) BPUM_1246 ENOG4108TGC Acyltransferase BPUM_1247 ENOG4105BZU Histidine kinase BPUM_1248 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BPUM_1249 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BPUM_1250 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BPUM_1252 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BPUM_1253 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BPUM_1254 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BPUM_1255 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BPUM_1257 ENOG4105BZU Histidine kinase BPUM_1258 ENOG41090MY MarR family Transcriptional regulator BPUM_1259 ENOG4105ER2 Ompa motb domain protein BPUM_1260 ENOG4105E14 MotA TolQ exbB proton channel BPUM_1262 ENOG4108K88 Membrane BPUM_1263 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BPUM_1264 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BPUM_1265 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BPUM_1266 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BPUM_1269 ENOG4108MK9 spermidine N(1)-acetyltransferase BPUM_1272 ENOG4105F0V Cell wall hydrolase BPUM_1275 ENOG4105C59 p-type ATPase BPUM_1276 ENOG4105DC7 peptidase M24 BPUM_1278 ENOG4105CID antiterminator BPUM_1280 ENOG4105KRI phosphocarrier protein (HPr BPUM_1281 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BPUM_1283 ENOG4105F6S Spore photoproduct lyase BPUM_1284 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BPUM_1285 ENOG4105CHR reductase BPUM_1286 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BPUM_1288 ENOG4105K4I Scp-like extracellular BPUM_1290 ENOG4105BZU Histidine kinase BPUM_1291 ENOG4105CHM Aminotransferase BPUM_1294 ENOG41085PJ rdd domain containing protein BPUM_1296 ENOG4107R88 Chemotaxis protein (CheV) BPUM_1297 ENOG4105UIN BPUM_1301 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein BPUM_1303 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BPUM_1304 ENOG4105EPM Diguanylate phosphodiesterase BPUM_1305 ENOG4105WEF catalase BPUM_1306 ENOG4107IN1 Protein of unknown function (DUF1797) BPUM_1307 ENOG4108XRC Protein of unknown function (DUF458) BPUM_1314 ENOG4105NQC Flavodoxin BPUM_1315 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BPUM_1317 ENOG4106AUC UPF0180 protein BPUM_1318 ENOG4105D8X mechanosensitive ion channel BPUM_1319 ENOG4105D3R alkyl hydroperoxide reductase BPUM_1320 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BPUM_1323 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BPUM_1324 ENOG4105D06 uba thif-type nad fad binding protein BPUM_1325 ENOG4105CVM Molybdenum cofactor synthesis domain protein BPUM_1326 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BPUM_1327 ENOG4108ZAF Molybdopterin BPUM_1328 ENOG41067WU Molybdopterin converting factor (Subunit 1) BPUM_1331 ENOG4107X8C Efflux transporter RND family MFP subunit BPUM_1332 ENOG4105C19 ABC transporter BPUM_1333 ENOG4107RBB ABC transporter, permease BPUM_1334 ENOG4105E98 transcriptional regulator DeoR family BPUM_1335 ENOG4105DE4 1-phosphofructokinase BPUM_1336 ENOG4105DM4 PTS System BPUM_1337 ENOG4105C3F Signal peptidase i BPUM_1339 ENOG4105C5H ABC transporter BPUM_1345 ENOG4105BZU Histidine kinase BPUM_1347 ENOG4107ZYR domain protein BPUM_1348 ENOG4105CPN adenine deaminase BPUM_1349 ENOG4105CN5 Metallo-Beta-Lactamase BPUM_1351 ENOG4108X4Q Hydrolase BPUM_1352 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BPUM_1356 ENOG4105CPP Dehydrogenase, E1 component BPUM_1357 ENOG4105C7S Dehydrogenase BPUM_1358 ENOG4107QN2 dihydrolipoyl dehydrogenase BPUM_1361 ENOG4105CXN decarboxylase BPUM_1363 ENOG4108WQ8 UPF0637 protein BPUM_1365 ENOG4105ECY inositol monophosphatase BPUM_1368 ENOG4105CI3 gtp-binding protein typa BPUM_1369 ENOG4105QA2 BPUM_1372 ENOG4108IAB Phoh family BPUM_1374 ENOG4105CSV Glutaminase BPUM_1376 ENOG4105CNI cell division protein FtsW BPUM_1377 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BPUM_1378 ENOG4105CVP deoxyribo-dipyrimidine photolyase BPUM_1380 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BPUM_1382 ENOG4105BZ9 Cytochrome C oxidase, subunit I BPUM_1383 ENOG4105CCU oxidase (Subunit III) BPUM_1384 ENOG41064X9 cytochrome C oxidase subunit IV BPUM_1387 ENOG41080XQ Signal transduction protein with cbs domains BPUM_1388 ENOG4106UY4 Inherit from COG: Scp-like extracellular BPUM_1393 ENOG4105WUC UPF0298 protein BPUM_1394 ENOG4106H78 methyltransferase BPUM_1395 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BPUM_1396 ENOG4105H20 Sporulation integral membrane protein YlbJ BPUM_1397 ENOG4105D78 K07001 NTE family protein BPUM_1398 ENOG41063PX domain protein BPUM_1399 ENOG4105CDE UPF0348 protein BPUM_1400 ENOG4105KNH Nucleic acid-binding protein BPUM_1401 ENOG41067VY 50S ribosomal protein L32 BPUM_1406 ENOG4108V6E Cell division protein mraZ BPUM_1407 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BPUM_1409 ENOG4105CJN penicillin-binding protein BPUM_1410 ENOG4105CJN penicillin-binding protein BPUM_1411 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BPUM_1412 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BPUM_1413 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BPUM_1414 ENOG4105CNI cell division protein FtsW BPUM_1415 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BPUM_1416 ENOG4105D4A Cell wall formation (By similarity) BPUM_1417 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BPUM_1418 ENOG4108R2U division initiation protein BPUM_1420 ENOG4105K67 small basic protein BPUM_1421 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BPUM_1422 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BPUM_1425 ENOG4105FFI sigma-e processing peptidase spoiiga BPUM_1426 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BPUM_1428 ENOG4105DKT Transcriptional regulator BPUM_1431 ENOG410787A Pts system, glucitol sorbitol-specific BPUM_1432 ENOG4105DZY Pts system, glucitol sorbitol-specific BPUM_1433 ENOG4105VI0 Pts system, glucitol sorbitol-specific BPUM_1434 ENOG4105DKW ABC transporter BPUM_1435 ENOG4105WR5 sporulation protein, YlmC YmxH family BPUM_1436 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BPUM_1437 ENOG4105DFA alanine racemase domain protein BPUM_1438 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BPUM_1439 ENOG41067XK integral membrane protein BPUM_1440 ENOG4105DBK s4 domain protein BPUM_1442 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BPUM_1444 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BPUM_1445 ENOG4105C34 Pseudouridine synthase BPUM_1446 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BPUM_1448 ENOG4105CXT aspartate transcarbamylase BPUM_1449 ENOG4105CD3 dihydroorotase BPUM_1450 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BPUM_1451 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BPUM_1452 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BPUM_1453 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BPUM_1454 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BPUM_1455 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BPUM_1456 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BPUM_1458 ENOG4107RIQ Sulfate adenylate transferase BPUM_1459 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) BPUM_1460 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BPUM_1461 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BPUM_1462 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BPUM_1463 ENOG4105F23 Fibronectin-binding protein BPUM_1465 ENOG4105DSJ YicC domain protein BPUM_1466 ENOG4105KC4 UPF0296 protein BPUM_1467 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BPUM_1469 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BPUM_1470 ENOG4105C25 Primosomal protein n' BPUM_1471 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BPUM_1472 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BPUM_1473 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BPUM_1474 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BPUM_1475 ENOG4108ZF3 Phosphatase BPUM_1476 ENOG4105D9P serine threonine protein kinase BPUM_1477 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BPUM_1478 ENOG4105DJV ribulose-phosphate 3-epimerase BPUM_1479 ENOG4105FJ0 thiamine BPUM_1481 ENOG4105VB9 50S ribosomal protein l28 BPUM_1482 ENOG4108ZAA Alkaline-shock protein BPUM_1483 ENOG4105DP4 dak2 domain fusion protein ylov BPUM_1485 ENOG4105EJQ L-serine dehydratase BPUM_1486 ENOG4105CB5 ATP-dependent DNA helicase recG BPUM_1487 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BPUM_1488 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BPUM_1489 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BPUM_1490 ENOG4105CHR reductase BPUM_1491 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BPUM_1492 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BPUM_1493 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BPUM_1494 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BPUM_1495 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BPUM_1497 ENOG4105K5M 30s ribosomal protein S16 BPUM_1498 ENOG4108BW8 UPF0109 protein BPUM_1500 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BPUM_1501 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BPUM_1502 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BPUM_1503 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BPUM_1504 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BPUM_1506 ENOG4105VM1 flagellar BPUM_1507 ENOG4105CMV Succinyl-CoA synthetase subunit beta BPUM_1508 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BPUM_1509 ENOG4105C79 DNA protecting protein DprA BPUM_1510 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BPUM_1511 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BPUM_1512 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BPUM_1513 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BPUM_1514 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BPUM_1516 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BPUM_1517 ENOG4108ZC9 flagellar basal-body rod protein flgc BPUM_1518 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BPUM_1519 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BPUM_1520 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BPUM_1523 ENOG4106YF4 Flagellar biosynthesis chaperone BPUM_1525 ENOG410696Y Flagellar hook-length control protein BPUM_1526 ENOG410822I Flagellar hook capping protein BPUM_1527 ENOG4108JQA flagellar BPUM_1528 ENOG41068WV flagellar FlbD family protein BPUM_1530 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BPUM_1531 ENOG4105DD5 Flagellar motor switch protein BPUM_1532 ENOG4107YTP response regulator receiver protein BPUM_1534 ENOG4105CN7 Flagellar biosynthetic protein FliP BPUM_1535 ENOG4105VS8 Flagellar biosynthetic protein fliq BPUM_1536 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BPUM_1537 ENOG4105D00 flagellar biosynthetic protein flhB BPUM_1538 ENOG4105D7B Flagellar biosynthesis protein flha BPUM_1539 ENOG4105FZW flagellar biosynthesis regulator FlhF BPUM_1541 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BPUM_1542 ENOG4105CBS Chea signal transduction histidine kinase BPUM_1543 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BPUM_1545 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BPUM_1546 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BPUM_1549 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BPUM_1551 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BPUM_1552 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BPUM_1553 ENOG4105KNE Phosphatidate cytidylyltransferase BPUM_1554 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BPUM_1555 ENOG4105DZP Membrane-associated zinc metalloprotease BPUM_1556 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BPUM_1557 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BPUM_1559 ENOG4105CYP glycoside hydrolase, family BPUM_1560 ENOG4105WJF BPUM_1562 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BPUM_1563 ENOG4105CHV Transcription elongation factor NusA BPUM_1564 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BPUM_1565 ENOG4105VHM ribosomal protein BPUM_1566 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BPUM_1567 ENOG4105W7A Protein of unknown function (DUF503) BPUM_1568 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BPUM_1569 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BPUM_1570 ENOG4105DTN riboflavin biosynthesis protein ribF BPUM_1571 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BPUM_1572 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BPUM_1574 ENOG4105C1V Peptidase, M16 BPUM_1577 ENOG4105E35 Dipicolinate synthase subunit A BPUM_1578 ENOG4108S0H Dipicolinic acid synthetase, b subunit BPUM_1579 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BPUM_1581 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BPUM_1583 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BPUM_1585 ENOG4105CNU cell division protein FtsK BPUM_1586 ENOG4105FDP GntR family transcriptional regulator BPUM_1587 ENOG4105EYF MMPL domain protein BPUM_1591 ENOG4105EYF MMPL domain protein BPUM_1592 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BPUM_1593 ENOG4105XZV Protein of unknown function (DUF3243) BPUM_1596 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BPUM_1597 ENOG4105CEV competence damage-inducible protein BPUM_1598 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BPUM_1599 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BPUM_1600 ENOG4105D48 metallophosphoesterase BPUM_1601 ENOG4105MCT stage V sporulation protein S BPUM_1603 ENOG4105CPQ Dehydrogenase BPUM_1604 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BPUM_1605 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BPUM_1608 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BPUM_1609 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BPUM_1613 ENOG4108VJ1 Transcriptional regulator (CarD family BPUM_1614 ENOG4105K7W phage-related replication protein BPUM_1616 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BPUM_1617 ENOG4105K7W phage-related replication protein BPUM_1618 ENOG4108X3M OsmC Ohr family protein BPUM_1619 ENOG410814C multidrug resistance protein BPUM_1624 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BPUM_1628 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BPUM_1629 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BPUM_1630 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BPUM_1631 ENOG4105U6W MutT NUDIX family protein BPUM_1633 ENOG4106F1P AAA ATPase, central domain protein BPUM_1634 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BPUM_1635 ENOG4105CXI aluminum resistance protein BPUM_1636 ENOG4105KV4 Transcriptional regulator BPUM_1637 ENOG4105C5F glutamine synthetase BPUM_1659 ENOG4108ZMX Domain of unknown function (DU1801) BPUM_1663 ENOG410780I phosphoprotein phosphatase activity BPUM_1665 ENOG4105XPP Protein of unknown function (DUF1275) BPUM_1666 ENOG4105DQE DNA ligase BPUM_1667 ENOG4105FDF Could be involved in DNA repair (By similarity) BPUM_1668 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BPUM_1670 ENOG4108Z40 Transcriptional regulator BPUM_1671 ENOG4105ECR NmrA family BPUM_1672 ENOG4107R5T Cysteine-rich domain BPUM_1673 ENOG4107QR9 Iron-sulfur cluster binding protein BPUM_1674 ENOG41080R8 Conserved Protein BPUM_1679 ENOG41082JN Transcriptional regulator BPUM_1680 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BPUM_1681 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases BPUM_1682 ENOG4105WFK nuclease BPUM_1683 ENOG4106SCS STAS domain BPUM_1686 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BPUM_1688 ENOG4108SVB resolvase BPUM_1689 ENOG4105VPS UPF0291 protein BPUM_1690 ENOG4105CV1 Transketolase (EC 2.2.1.1) BPUM_1692 ENOG4105VXM UPF0154 protein BPUM_1694 ENOG4107QIV Cytochrome c biogenesis protein BPUM_1699 ENOG4108I0Z Aconitate hydratase BPUM_1700 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BPUM_1705 ENOG4105MI2 BPUM_1706 ENOG4105W8X HesB YadR YfhF-family protein BPUM_1707 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BPUM_1708 ENOG4105K4P CoA-binding domain protein BPUM_1709 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BPUM_1713 ENOG4106UW1 Major Facilitator superfamily BPUM_1721 ENOG4105DYS nad(p)h dehydrogenase (quinone) BPUM_1722 ENOG4105KVH Transcriptional regulator BPUM_1723 ENOG4105C6T cysteine synthase BPUM_1724 ENOG4105KME endoribonuclease L-psp BPUM_1732 ENOG4106H6A BPUM_1733 ENOG4105N0V mono-oxygenase ydhR BPUM_1740 ENOG4108Z6Z Transcriptional regulator BPUM_1741 ENOG4105CS2 ec 3.2.1.21 BPUM_1742 ENOG4105C5Y PTS System BPUM_1746 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BPUM_1748 ENOG4107SYN Glycosyl hydrolases family 43 BPUM_1751 ENOG4105I1K ABC transporter BPUM_1752 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BPUM_1755 ENOG4105UP7 3-epimerase BPUM_1758 ENOG4106ETB IIa component BPUM_1767 ENOG4105D2N Aldolase BPUM_1768 ENOG4105DM4 PTS System BPUM_1769 ENOG4105DM4 PTS System BPUM_1770 ENOG4105DE4 1-phosphofructokinase BPUM_1771 ENOG4105HX0 Transcriptional regulator BPUM_1772 ENOG4107RZC phospholipase d BPUM_1776 ENOG4105C26 Dehydrogenase BPUM_1777 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BPUM_1779 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BPUM_1780 ENOG4107QX3 carboxylase BPUM_1781 ENOG4105E39 Enoyl-CoA hydratase BPUM_1782 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BPUM_1783 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BPUM_1784 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BPUM_1785 ENOG4105CEY Amp-dependent synthetase and ligase BPUM_1786 ENOG4105C1G acyl-Coa dehydrogenase BPUM_1787 ENOG4105F32 YngK protein BPUM_1792 ENOG4105CQB FAD linked oxidase domain protein BPUM_1793 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BPUM_1795 ENOG4108B31 Spore germination protein BPUM_1800 ENOG4107T5V SNARE associated Golgi BPUM_1801 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BPUM_1803 ENOG4105DEN Luciferase family BPUM_1806 ENOG4107QJQ Mate efflux family protein BPUM_1807 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BPUM_1808 ENOG4105NBR Pectinesterase BPUM_1809 ENOG4105H67 Protein of unknown function (DUF421) BPUM_1810 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BPUM_1811 ENOG4108IFG nitrite reductase, (NAD(P)H) BPUM_1813 ENOG4105BZ8 glutamate synthase BPUM_1814 ENOG4105CBC glutamate synthase BPUM_1815 ENOG4105C5Q Transcriptional regulator BPUM_1817 ENOG4105BZ1 (ABC) transporter BPUM_1819 ENOG4108UYN gCN5-related N-acetyltransferase BPUM_1821 ENOG4105D9U N-acetyltransferase BPUM_1822 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BPUM_1823 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BPUM_1826 ENOG4108J2R molybdopterin oxidoreductase BPUM_1828 ENOG4105CMG Carbohydrate kinase BPUM_1830 ENOG4105E2R ROK family BPUM_1832 ENOG4105CT4 transporter BPUM_1833 ENOG4108Z7R Chaperone CsaA BPUM_1835 ENOG4105FVX BPUM_1839 ENOG4108W8B Beta-lactamase domain protein BPUM_1841 ENOG4105D29 Helix-turn-helix type 11 domain protein BPUM_1843 ENOG4105KTU Transcriptional regulator, arsr family BPUM_1844 ENOG4105CUB amino acid BPUM_1846 ENOG4105CR4 methylisocitrate lyase BPUM_1847 ENOG4105DXD 2-methylcitrate dehydratase BPUM_1849 ENOG4108SJC Membrane BPUM_1851 ENOG41069ER domain protein BPUM_1852 ENOG4105C9U ATP-dependent DNA helicase RecQ BPUM_1853 ENOG4105SCY DNAK suppressor BPUM_1857 ENOG4105C26 Dehydrogenase BPUM_1858 ENOG4105EWU Squalene--hopene cyclase BPUM_1859 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BPUM_1860 ENOG4105C09 Bile acid BPUM_1861 ENOG4105C7S Dehydrogenase BPUM_1862 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BPUM_1863 ENOG4107T89 von Willebrand factor, type A BPUM_1864 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BPUM_1868 ENOG4107QMU Mate efflux family protein BPUM_1872 ENOG4105FR1 rard protein BPUM_1878 ENOG4105E1V na solute symporter BPUM_1879 ENOG4105JQZ Methyltransferase BPUM_1883 ENOG4108VXD carboxy-peptidase BPUM_1884 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BPUM_1885 ENOG4106Z5R BPUM_1886 ENOG410841Q phosphoesterase PA-phosphatase related protein BPUM_1890 ENOG4105VSD UPF0346 protein BPUM_1892 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BPUM_1893 ENOG4108JUB Transcriptional regulator BPUM_1899 ENOG4105C5E polysaccharide biosynthesis protein BPUM_1900 ENOG4105E0X reductase BPUM_1901 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BPUM_1906 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BPUM_1907 ENOG41090WU lipolytic protein G-D-S-L family BPUM_1908 ENOG4108KF3 Electron transport protein SCO1 SenC BPUM_1911 ENOG4105C7B Threonine dehydratase BPUM_1913 ENOG4108UT2 hemolysin iii BPUM_1915 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BPUM_1916 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BPUM_1920 ENOG4107YX5 Pfam:DUF548 BPUM_1921 ENOG4108Y6J UPF0403 protein BPUM_1922 ENOG4105C01 Dihydroxy-acid dehydratase BPUM_1925 ENOG4108V06 Glutathione peroxidase BPUM_1926 ENOG4105CKU formyltetrahydrofolate synthetase BPUM_1927 ENOG4105CVG Homoserine O-transsuccinylase BPUM_1928 ENOG4108QBV Monogalactosyldiacylglycerol synthase BPUM_1935 ENOG41081VK Ribonuclease BPUM_1939 ENOG410890F Dynamin family BPUM_1941 ENOG41065KQ synthase BPUM_1942 ENOG4107VMI polysaccharide deacetylase BPUM_1943 ENOG4105C2W permease BPUM_1945 ENOG4105CTD carboxy-peptidase BPUM_1946 ENOG4105DVT helicase BPUM_1948 ENOG4105DQ6 Transposase BPUM_1950 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BPUM_1951 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BPUM_1952 ENOG4108UKS UPF0398 protein BPUM_1953 ENOG4107X2U Inherit from COG: Exonuclease-like protein BPUM_1954 ENOG4108I5C dEAD DEAH box helicase BPUM_1955 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BPUM_1963 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BPUM_1964 ENOG4105BZ4 penicillin-binding protein BPUM_1966 ENOG4105CSM endonuclease III BPUM_1970 ENOG4105YAC BPUM_1971 ENOG4105DVT helicase BPUM_1972 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BPUM_1973 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BPUM_1974 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BPUM_1976 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BPUM_1977 ENOG4105CPK Glycosyl transferase (Group 1 BPUM_1978 ENOG4105FJR Lmbe family BPUM_1979 ENOG4108Z5K methylglyoxal synthase BPUM_1980 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BPUM_1981 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BPUM_1982 ENOG4108JYZ YitT family BPUM_1986 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BPUM_1989 ENOG4108SXZ UPF0302 protein BPUM_1990 ENOG41068YB TPR repeat-containing protein BPUM_1991 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BPUM_1993 ENOG4105CIH Imidazole acetol-phosphate transaminase BPUM_1994 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BPUM_1995 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BPUM_1997 ENOG4105DK0 Indole-3-glycerol phosphate synthase BPUM_1998 ENOG4108I0Q anthranilate phosphoribosyltransferase BPUM_2000 ENOG4105KHN chorismate mutase BPUM_2001 ENOG4105D49 3-dehydroquinate synthase BPUM_2002 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BPUM_2003 ENOG4105BZU Histidine kinase BPUM_2004 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BPUM_2005 ENOG4105EAH synthase BPUM_2006 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BPUM_2007 ENOG4105XXQ heptaprenyl diphosphate synthase component I BPUM_2009 ENOG4105EUJ GTP cyclohydrolase i BPUM_2010 ENOG4105K70 DNA-binding protein BPUM_2011 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BPUM_2014 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BPUM_2015 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BPUM_2016 ENOG41065D1 BPUM_2017 ENOG4105S2F BPUM_2021 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BPUM_2022 ENOG4105CAT Cytidine monophosphate kinase BPUM_2025 ENOG4105MSI germination protein ypeb BPUM_2027 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BPUM_2028 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BPUM_2031 ENOG4107RGJ metallophosphoesterase BPUM_2034 ENOG4105I7S Abortive infection protein BPUM_2035 ENOG4105C9U ATP-dependent DNA helicase RecQ BPUM_2036 ENOG4105T7X BPUM_2038 ENOG4108SAX Membrane BPUM_2039 ENOG4108JQ1 Dehydrogenase BPUM_2040 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BPUM_2044 ENOG4105BZU Histidine kinase BPUM_2045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BPUM_2046 ENOG4105CRE cytochrome C BPUM_2047 ENOG4107TWT Cytochrome c biogenesis protein BPUM_2049 ENOG4105FE9 pseudouridine synthase BPUM_2051 ENOG4108JIC nucleoside recognition domain protein BPUM_2052 ENOG4105DZ1 carboxypeptidase BPUM_2054 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BPUM_2055 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BPUM_2059 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BPUM_2060 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BPUM_2061 ENOG4108R6K riboflavin synthase, subunit alpha BPUM_2065 ENOG4105EQ0 Major Facilitator superfamily BPUM_2066 ENOG4107ZE5 PPIases accelerate the folding of proteins BPUM_2067 ENOG4105PTM secreted protein BPUM_2068 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BPUM_2070 ENOG4105G6R Stage v sporulation protein ae BPUM_2072 ENOG4105CZ3 stage V sporulation protein ad BPUM_2073 ENOG41090VF Stage v sporulation protein ac BPUM_2076 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BPUM_2077 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BPUM_2078 ENOG41082AN stage II sporulation protein BPUM_2079 ENOG4105DZ1 carboxypeptidase BPUM_2080 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BPUM_2081 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BPUM_2082 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BPUM_2084 ENOG4105I3K Ferric uptake regulator, Fur family BPUM_2085 ENOG4105MZ9 stage II sporulation protein m BPUM_2088 ENOG4107YB6 acetyltransferase, (GNAT) family BPUM_2090 ENOG4108YZ4 nudix hydrolase BPUM_2091 ENOG4105CPC Aldo Keto reductase BPUM_2098 ENOG4106HZJ BPUM_2099 ENOG4105RHY Pfam:UPF0157 BPUM_2100 ENOG4108XET gCN5-related N-acetyltransferase BPUM_2102 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BPUM_2104 ENOG4105E5W Transporter BPUM_2106 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BPUM_2107 ENOG4108IXY short-chain dehydrogenase reductase BPUM_2108 ENOG41069FQ Metallo-beta-lactamase superfamily BPUM_2109 ENOG4105II7 pyrroline-5-carboxylate reductase BPUM_2112 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BPUM_2114 ENOG4105XT2 Transcriptional regulator BPUM_2115 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BPUM_2116 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BPUM_2117 ENOG4108TZY GntR Family Transcriptional Regulator BPUM_2118 ENOG4105CS2 ec 3.2.1.21 BPUM_2119 ENOG4105CK1 PTS System BPUM_2120 ENOG4105VCP PTS System BPUM_2121 ENOG4105VZJ PTS System BPUM_2122 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BPUM_2123 ENOG4105CSC Glucose uptake protein BPUM_2124 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BPUM_2125 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BPUM_2128 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BPUM_2130 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BPUM_2131 ENOG4108HNZ carboxyl transferase BPUM_2132 ENOG4108ZVT methylmalonyl-coA epimerase BPUM_2134 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BPUM_2135 ENOG4108QEG Membrane BPUM_2136 ENOG4105CDA abc transporter atp-binding protein BPUM_2137 ENOG4105E5Q amino acid AbC transporter BPUM_2138 ENOG4108HW3 (ABC) transporter BPUM_2139 ENOG4108Y6J UPF0403 protein BPUM_2140 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BPUM_2142 ENOG4105C7S Dehydrogenase BPUM_2143 ENOG4105CPP Dehydrogenase, E1 component BPUM_2146 ENOG4105CKM Branched-chain carboxylic acid kinase BPUM_2147 ENOG4107RDP Dehydrogenase BPUM_2149 ENOG4108JUB Transcriptional regulator BPUM_2150 ENOG4106CCJ Protein of unknown function (DUF2627) BPUM_2151 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BPUM_2154 ENOG4107QQR Sporulation BPUM_2155 ENOG4105S1Z Stage IV sporulation protein B BPUM_2156 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BPUM_2157 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BPUM_2158 ENOG4105DX0 Hemolysin A BPUM_2159 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BPUM_2160 ENOG4105CTB Polyprenyl synthetase BPUM_2161 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BPUM_2162 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BPUM_2163 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BPUM_2164 ENOG4105M7K Involved in the transcription termination process (By similarity) BPUM_2165 ENOG4108ZSR alkaline shock protein BPUM_2166 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BPUM_2170 ENOG410644B Stage III sporulation protein af BPUM_2172 ENOG4105KQ4 Stage iii sporulation protein ad BPUM_2173 ENOG4108CQH stage III sporulation protein AC BPUM_2174 ENOG4105KR5 Stage iii sporulation protein BPUM_2175 ENOG4105CD2 stage iii sporulation protein aa BPUM_2177 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BPUM_2178 ENOG4105DC7 peptidase M24 BPUM_2179 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BPUM_2181 ENOG4105CBJ Metal-dependent enzyme BPUM_2184 ENOG4105KST dependent repressor BPUM_2185 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BPUM_2186 ENOG4105WZW rhodanese family BPUM_2187 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BPUM_2189 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BPUM_2190 ENOG4105C0D helicase BPUM_2193 ENOG4108IMY Transcriptional regulator BPUM_2195 ENOG4105VFR signal peptidase BPUM_2203 ENOG4106855 Competence protein BPUM_2209 ENOG4105C5X domain protein BPUM_2214 ENOG4105E0M Sulfatase BPUM_2217 ENOG4107ZXI Rhomboid family BPUM_2219 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BPUM_2220 ENOG4105WDJ 50S ribosomal protein L33 BPUM_2222 ENOG41068DG YceG-like family BPUM_2223 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BPUM_2224 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BPUM_2225 ENOG4105E2Z phosphate ABC transporter (Permease BPUM_2226 ENOG4105C8U phosphate abc transporter BPUM_2227 ENOG4105CVA phosphate BPUM_2228 ENOG4107RF6 penicillin-binding protein BPUM_2230 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BPUM_2231 ENOG4105SXS Protein of unknown function (DUF456) BPUM_2233 ENOG4105D9U N-acetyltransferase BPUM_2235 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BPUM_2236 ENOG41063Y9 BPUM_2237 ENOG4108U5J '-nucleotidase BPUM_2238 ENOG41066F8 ROK family BPUM_2241 ENOG4105N80 Ferric uptake regulator, Fur family BPUM_2242 ENOG4105FAV ABC, transporter BPUM_2243 ENOG4105FDK ABC transporter BPUM_2244 ENOG4108JYZ YitT family BPUM_2245 ENOG41069ZM Protein of unknown function (DUF2624) BPUM_2246 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BPUM_2249 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BPUM_2250 ENOG4105EGD dinuclear metal center protein, YbgI family BPUM_2253 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BPUM_2254 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BPUM_2255 ENOG4108UPT UPF0178 protein BPUM_2256 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BPUM_2258 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BPUM_2259 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BPUM_2260 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BPUM_2262 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BPUM_2263 ENOG4105KG3 cytidine deaminase BPUM_2264 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BPUM_2265 ENOG4105CTJ Metal Dependent Phosphohydrolase BPUM_2266 ENOG4105C9A Phoh family BPUM_2267 ENOG4105EI1 sporulation protein yqfd BPUM_2268 ENOG41068P3 sporulation protein YqfC BPUM_2271 ENOG4105DI5 UPF0365 protein BPUM_2272 ENOG4105F7J membrane-bound serine protease BPUM_2273 ENOG4105KTH gatB Yqey BPUM_2276 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BPUM_2277 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BPUM_2278 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BPUM_2279 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BPUM_2281 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BPUM_2282 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BPUM_2283 ENOG4105CSA Coproporphyrinogen iii oxidase BPUM_2284 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BPUM_2286 ENOG4108ZRV stage ii sporulation protein p BPUM_2289 ENOG4105TQK DNA polymerase iii, delta' subunit BPUM_2291 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BPUM_2292 ENOG4108UK2 deaminase BPUM_2293 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BPUM_2295 ENOG4108D32 Methyltransferase BPUM_2297 ENOG4108WF2 Metal Dependent Phosphohydrolase BPUM_2298 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BPUM_2299 ENOG410812S Rna-binding protein BPUM_2300 ENOG4105E2X shikimate dehydrogenase BPUM_2301 ENOG4105CQW ribosome biogenesis GTPase YqeH BPUM_2302 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BPUM_2309 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BPUM_2320 ENOG4108ZJ4 polysaccharide deacetylase BPUM_2326 ENOG4107QNK )-transporter BPUM_2327 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BPUM_2330 ENOG4105CMD Transcriptional regulator, GntR family BPUM_2332 ENOG41080HJ 6-phospho 3-hexuloisomerase BPUM_2333 ENOG4108VA3 3-hexulose-6-phosphate synthase BPUM_2334 ENOG4105KVH Transcriptional regulator BPUM_2339 ENOG4105CNA YD repeat protein BPUM_2340 ENOG4108HWY Beta-lactamase BPUM_2341 ENOG4105FDT acyl-CoA dehydrogenase BPUM_2345 ENOG4105E5Q amino acid AbC transporter BPUM_2346 ENOG4105WEF catalase BPUM_2349 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BPUM_2352 ENOG4107V2S Transcriptional regulator BPUM_2353 ENOG4105BZ1 (ABC) transporter BPUM_2354 ENOG4108UYN gCN5-related N-acetyltransferase BPUM_2355 ENOG4105E2A Dehydrogenase BPUM_2360 ENOG4105C28 cystathionine BPUM_2362 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BPUM_2363 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BPUM_2366 ENOG4107XRG penicillin-binding protein BPUM_2367 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BPUM_2369 ENOG4107S03 uridine kinase BPUM_2370 ENOG4105CFP Peptidase U32 BPUM_2371 ENOG4105XYU peptidase (U32 family) BPUM_2372 ENOG4108VQJ O-methyltransferase BPUM_2373 ENOG4105HHA aminodeoxychorismate lyase BPUM_2375 ENOG4107F3J Amp-dependent synthetase and ligase BPUM_2376 ENOG4107ZYJ bioY protein BPUM_2377 ENOG4105VPH UPF0473 protein BPUM_2378 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BPUM_2379 ENOG4105VBH UPF0297 protein BPUM_2381 ENOG4105C02 permease BPUM_2382 ENOG4105CDA abc transporter atp-binding protein BPUM_2383 ENOG4105CT1 (ABC) transporter BPUM_2384 ENOG4105EAD ABC transporter BPUM_2385 ENOG4105DRP amino acid AbC transporter BPUM_2387 ENOG41060CR BPUM_2389 ENOG4105C7H Helicase, RecD TraA family BPUM_2391 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BPUM_2392 ENOG4105C3J Cysteine desulfurase BPUM_2394 ENOG4105D1H recombination factor protein RarA BPUM_2395 ENOG4105CUZ uba thif-type nad fad binding protein BPUM_2396 ENOG4105C9M aspartyl-trna synthetase BPUM_2397 ENOG4105CUT histidyl-tRNA synthetase BPUM_2399 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BPUM_2400 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BPUM_2401 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BPUM_2402 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BPUM_2403 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BPUM_2404 ENOG41067VP Protein of unknown function (DUF1049) BPUM_2406 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BPUM_2408 ENOG4105CKP Polysaccharide Biosynthesis Protein BPUM_2409 ENOG4108QG2 Membrane BPUM_2410 ENOG4105NAP BPUM_2411 ENOG4105VIE preprotein translocase, subunit YajC BPUM_2412 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BPUM_2413 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BPUM_2414 ENOG41061AI Protein of unknown function (DUF2905) BPUM_2415 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BPUM_2416 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BPUM_2421 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BPUM_2424 ENOG4106678 morphogenetic protein associated with SpoVID BPUM_2425 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BPUM_2426 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BPUM_2427 ENOG4108IYU L-aspartate oxidase BPUM_2430 ENOG4105CQC Prephenate dehydratase BPUM_2432 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BPUM_2434 ENOG4105K46 50S ribosomal protein l27 BPUM_2435 ENOG4105X36 (ribosomal) protein BPUM_2436 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BPUM_2439 ENOG4107QMS site-determining protein BPUM_2440 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BPUM_2441 ENOG4105YHC Rod shape-determining protein MreD BPUM_2442 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BPUM_2443 ENOG4105DFF Rod shape-determining protein mreb BPUM_2444 ENOG4105W5Q DNA repair protein (RadC BPUM_2445 ENOG4108Z03 MAF-like protein BPUM_2447 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) BPUM_2448 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BPUM_2449 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BPUM_2451 ENOG4106AR7 Spore coat protein BPUM_2452 ENOG41068KH stage VI sporulation protein D BPUM_2453 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BPUM_2454 ENOG4105D52 delta-aminolevulinic acid dehydratase BPUM_2456 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BPUM_2458 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BPUM_2460 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BPUM_2461 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BPUM_2462 ENOG4108IUQ atp-dependent protease BPUM_2463 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BPUM_2464 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BPUM_2466 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BPUM_2467 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BPUM_2468 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BPUM_2469 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BPUM_2470 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BPUM_2471 ENOG4108ZP8 Acetolactate synthase small subunit BPUM_2472 ENOG4105C7K acetolactate synthase BPUM_2473 ENOG4105CM2 brancheD-chain amino acid aminotransferase BPUM_2474 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BPUM_2476 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BPUM_2478 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BPUM_2479 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BPUM_2481 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BPUM_2488 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BPUM_2489 ENOG4105M59 Phosphodiesterase, mj0936 family BPUM_2490 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BPUM_2491 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BPUM_2492 ENOG4108XJQ germination protein BPUM_2493 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BPUM_2494 ENOG41067TZ transcriptional regulator, MarR family BPUM_2495 ENOG4105PFC Transcriptional regulator BPUM_2497 ENOG4108KAM Transcriptional regulator BPUM_2498 ENOG4105C7F AcnD-accessory protein PrpF BPUM_2499 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BPUM_2501 ENOG4105E33 succinate dehydrogenase BPUM_2503 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BPUM_2505 ENOG4105CFH Aspartokinase BPUM_2506 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BPUM_2507 ENOG4105K63 Thioredoxin BPUM_2508 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BPUM_2509 ENOG4105C10 Electron transfer flavoprotein BPUM_2510 ENOG4105BZJ Electron transfer flavoprotein BPUM_2511 ENOG41060WC Enoyl-CoA hydratase BPUM_2512 ENOG4107Z3H Transcriptional regulator, TetR family BPUM_2513 ENOG4105CEY Amp-dependent synthetase and ligase BPUM_2516 ENOG4105C98 muts2 protein BPUM_2517 ENOG4105DCG PHP domain protein BPUM_2519 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BPUM_2520 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BPUM_2521 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BPUM_2522 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BPUM_2523 ENOG4108RWN rrna methyltransferase BPUM_2524 ENOG41067MF small acid-soluble spore protein BPUM_2527 ENOG4105CN9 Peptidase m42 family protein BPUM_2529 ENOG410696E Membrane BPUM_2530 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BPUM_2531 ENOG4105VJV 50s ribosomal protein L35 BPUM_2532 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BPUM_2533 ENOG41067MG lrgb family BPUM_2535 ENOG4105DY9 regulatoR BPUM_2536 ENOG4108HRK Histidine kinase BPUM_2537 ENOG4105U0R haloacid dehalogenase-like hydrolase BPUM_2538 ENOG4107SDU Methyl-accepting chemotaxis BPUM_2539 ENOG4105C22 threonyL-tRNA synthetase BPUM_2540 ENOG4108TDW sporulation protein YtxC BPUM_2546 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BPUM_2547 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BPUM_2548 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BPUM_2550 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BPUM_2551 ENOG4105C2M dna polymerase I BPUM_2552 ENOG4105BZU Histidine kinase BPUM_2553 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BPUM_2554 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BPUM_2555 ENOG4108HMX isocitrate dehydrogenase (NADP) BPUM_2556 ENOG4105BZN citrate synthase BPUM_2558 ENOG4107CWS Protein of unknown function (DUF441) BPUM_2559 ENOG4108REF Sporulation integral membrane protein ytvi BPUM_2560 ENOG4105FS0 cytoplasmic membrane protein BPUM_2561 ENOG4105CA9 Pyruvate kinase BPUM_2562 ENOG4105CTQ phosphohexokinase BPUM_2564 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BPUM_2565 ENOG4105C6K Malic enzyme BPUM_2566 ENOG4105C0B DNA polymerase III (alpha subunit) BPUM_2567 ENOG4105VV2 BPUM_2569 ENOG4106EVM BPUM_2570 ENOG4105SFS phosphoesterase RecJ domain protein BPUM_2573 ENOG4105E8R UPF0173 metal-dependent hydrolase BPUM_2576 ENOG4105CH7 arginosuccinase BPUM_2577 ENOG4105CDH Citrulline--aspartate ligase BPUM_2579 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BPUM_2581 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BPUM_2582 ENOG4105KBJ sporulation protein ytfj BPUM_2584 ENOG4105VK3 rdd domain containing protein BPUM_2585 ENOG4105D07 Signal peptide peptidase, SppA BPUM_2586 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BPUM_2587 ENOG4105C1J atp-dependent rna helicase BPUM_2588 ENOG4105ECK Fatty Acid Desaturase BPUM_2589 ENOG4108ZGX Histidine kinase BPUM_2590 ENOG4108S01 response regulator BPUM_2591 ENOG4108V5C ABC transporter BPUM_2593 ENOG4105EWM Histidine kinase BPUM_2594 ENOG4105C19 ABC transporter BPUM_2596 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BPUM_2597 ENOG4108X0B nad(p)h dehydrogenase (quinone) BPUM_2599 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BPUM_2600 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BPUM_2602 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BPUM_2608 ENOG4105U5Y Transcriptional regulator BPUM_2610 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BPUM_2613 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BPUM_2614 ENOG4105KAC Antibiotic biosynthesis monooxygenase BPUM_2615 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BPUM_2617 ENOG4105F1V Acetoin utilization protein BPUM_2618 ENOG4105W87 Cbs domain BPUM_2619 ENOG4105DGU Histone deacetylase BPUM_2620 ENOG4105ETE Transcriptional regulator (LacI family BPUM_2621 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BPUM_2626 ENOG4105DFU Cell wall formation (By similarity) BPUM_2628 ENOG4108VDD TRNA binding domain protein BPUM_2629 ENOG4108NKM UPF0354 protein BPUM_2632 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BPUM_2635 ENOG4105C6K Malic enzyme BPUM_2636 ENOG4105C8F Beta-lactamase domain protein BPUM_2637 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BPUM_2639 ENOG4108V15 phosphotransferase enzyme family BPUM_2642 ENOG4107F58 2'-5' rna ligase BPUM_2643 ENOG4105C6T cysteine synthase BPUM_2644 ENOG4107UIE peptidase BPUM_2645 ENOG4107QSE Dipeptidase BPUM_2646 ENOG4105C7N Xanthine uracil vitamin C permease BPUM_2647 ENOG4105YW5 deoR family transcriptional regulator BPUM_2650 ENOG4105CBX hi0933 family BPUM_2652 ENOG4105C94 Transporter BPUM_2653 ENOG4106611 bacteriocin immunity BPUM_2655 ENOG41085GJ domain protein BPUM_2656 ENOG4105MU9 integral membrane protein BPUM_2657 ENOG4105DDC Oxidoreductase domain protein BPUM_2659 ENOG4105F5H Glycosyl Hydrolase Family 88 BPUM_2661 ENOG41075H3 AraC family transcriptional regulator BPUM_2662 ENOG4105KVH Transcriptional regulator BPUM_2663 ENOG4105F27 Major Facilitator BPUM_2664 ENOG4105CV8 reductase BPUM_2666 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BPUM_2668 ENOG4105NTD Inherit from COG: Hydrolase BPUM_2669 ENOG4105C8T Leucyl-tRNA synthetase BPUM_2671 ENOG4105BZU Histidine kinase BPUM_2672 ENOG4106UBQ BPUM_2673 ENOG4107R34 abc transporter permease protein BPUM_2674 ENOG4105C19 ABC transporter BPUM_2676 ENOG4105DVE abc transporter atp-binding protein BPUM_2677 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BPUM_2680 ENOG4105N5T Radical SAM Protein BPUM_2683 ENOG4105E8V Alpha Beta Hydrolase Fold protein BPUM_2684 ENOG4108Z0R Transferase BPUM_2685 ENOG4105CAQ asparagine synthetase BPUM_2686 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BPUM_2690 ENOG4105EWK phytoene BPUM_2694 ENOG4105D2X ABC transporter substrate-binding protein BPUM_2696 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BPUM_2698 ENOG4106FN3 tellurium resistance protein BPUM_2703 ENOG4108RMU ferritin dps family protein BPUM_2705 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BPUM_2706 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BPUM_2707 ENOG4108V2W Carbonate dehydratase BPUM_2708 ENOG4105DSE periplasmic solute binding protein BPUM_2709 ENOG4105NRA 50s ribosomal protein l31 type b BPUM_2714 ENOG4105DTQ mandelate racemase muconate lactonizing BPUM_2716 ENOG4108IPT Naphthoate synthase BPUM_2717 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BPUM_2718 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BPUM_2719 ENOG4105E4F Isochorismate synthase BPUM_2720 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BPUM_2723 ENOG4108606 TspO/MBR family BPUM_2725 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BPUM_2727 ENOG4105VRR gCN5-related N-acetyltransferase BPUM_2729 ENOG4105CNI cell division protein FtsW BPUM_2731 ENOG4105DZ6 Band 7 protein BPUM_2733 ENOG4106DF1 BPUM_2734 ENOG4108JB8 alcohol dehydrogenase BPUM_2735 ENOG4105C26 Dehydrogenase BPUM_2736 ENOG4105TRT Transcriptional regulator BPUM_2739 ENOG4108TGC Acyltransferase BPUM_2750 ENOG410906S phage-like element pbsx protein xkdt BPUM_2751 ENOG41066EA baseplate J family protein BPUM_2752 ENOG4105MFU Protein of unknown function (DUF2634) BPUM_2754 ENOG4105X7F BPUM_2755 ENOG4108WZM domain protein BPUM_2756 ENOG4108FKH Transglycosylase SLT domain BPUM_2756 ENOG4108FKH Transglycosylase SLT domain BPUM_2758 ENOG4105MTC XkdN-like protein BPUM_2760 ENOG4105FR7 XkdM protein, phage-like element PBSX BPUM_2761 ENOG4105PQS phage protein BPUM_2764 ENOG41060SN BPUM_2769 ENOG4108MDF Phage Portal Protein BPUM_2770 ENOG4105IG6 Phage terminase, large subunit BPUM_2774 ENOG4105QBX endodeoxyribonuclease RusA BPUM_2779 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BPUM_2782 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BPUM_2785 ENOG4105EE0 oxidoreductase BPUM_2786 ENOG4108Z0Z intracellular protease Pfpi family BPUM_2787 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_2788 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_2789 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_2790 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_2794 ENOG4105EA8 2-Nitropropane dioxygenase BPUM_2795 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BPUM_2796 ENOG4105C37 (CBS) domain BPUM_2799 ENOG4107PBV potassium channel BPUM_2802 ENOG4107QYV phosphohexose isomerase BPUM_2804 ENOG4107QW4 alcohol dehydrogenase BPUM_2805 ENOG4105WG9 Conserved Protein BPUM_2807 ENOG4105CHM Aminotransferase BPUM_2808 ENOG4108ZB6 transcriptional regulator AsnC family BPUM_2809 ENOG4108MUZ hydrolase BPUM_2811 ENOG4105C87 Aminotransferase class I and II BPUM_2812 ENOG4108HGU Histidine kinase BPUM_2814 ENOG4105Y38 Kinase-associated protein B BPUM_2817 ENOG4105BZ4 penicillin-binding protein BPUM_2818 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BPUM_2821 ENOG4108MRH transcriptional regulatory protein BPUM_2823 ENOG4105DIH basic membrane BPUM_2824 ENOG4108JQ9 ABC transporter BPUM_2825 ENOG4105UIB (ABC) transporter BPUM_2829 ENOG4105D65 subunit l BPUM_2830 ENOG4105HC0 Na H antiporter BPUM_2831 ENOG4108ZE9 Monovalent cation H antiporter subunit C BPUM_2832 ENOG4108JPZ Monovalent cation H antiporter subunit D BPUM_2833 ENOG4105SC1 monovalent cation H antiporter subunit E BPUM_2835 ENOG4105KJM monovalent cation h antiporter subunit g BPUM_2836 ENOG4105KA0 thioesterase Superfamily protein BPUM_2838 ENOG4105BZU Histidine kinase BPUM_2843 ENOG4105D58 Diguanylate phosphodiesterase BPUM_2844 ENOG4105DAP Nicotinate phosphoribosyltransferase BPUM_2850 ENOG4105C02 permease BPUM_2854 ENOG410904N short-chain dehydrogenase reductase BPUM_2861 ENOG4108K8K Transcriptional regulator BPUM_2862 ENOG4105DCF alanine dehydrogenase BPUM_2864 ENOG4108N23 SpoOM-related protein BPUM_2866 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BPUM_2869 ENOG41069ER domain protein BPUM_2872 ENOG4105CEP NADH dehydrogenase BPUM_2873 ENOG4105CAY ferredoxin--nadp reductase BPUM_2876 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BPUM_2877 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BPUM_2879 ENOG4105ZKE UPF0349 protein BPUM_2884 ENOG41083MR nifu domain-containing protein BPUM_2885 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BPUM_2887 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BPUM_2888 ENOG4105D6E homoserine dehydrogenase BPUM_2889 ENOG4105C5I Dehydrogenase BPUM_2891 ENOG4108W5N phosphatidylglycerophosphatase a BPUM_2892 ENOG4105D4U had-superfamily hydrolase, subfamily iia BPUM_2894 ENOG4105MMD transcriptional regulator BPUM_2895 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BPUM_2897 ENOG4105FAA peptidase M23 BPUM_2899 ENOG4108YTE sporulation protein YunB BPUM_2900 ENOG4105KZD Domain of unknown function (DUF1805) BPUM_2901 ENOG4107R8B 5'-nucleotidase BPUM_2902 ENOG4105I3N Conserved Protein BPUM_2903 ENOG4105G9B Transcriptional regulator BPUM_2904 ENOG4105F0F Oxalate decarboxylase BPUM_2906 ENOG4105C5R Aminotransferase BPUM_2907 ENOG4108K8S endonuclease I BPUM_2909 ENOG4108IHU transport system permease protein BPUM_2910 ENOG4105DQ5 transport system permease protein BPUM_2911 ENOG4108MES Periplasmic binding protein BPUM_2915 ENOG4108SWU Histidine kinase BPUM_2916 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BPUM_2918 ENOG4105DHF Membrane BPUM_2922 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BPUM_2923 ENOG4105DIW FeS assembly protein SUFB BPUM_2924 ENOG4108UNV SUF system FeS assembly protein, NifU family BPUM_2925 ENOG4105C9B Cysteine desulfurase BPUM_2926 ENOG4105JRK feS assembly protein SufD BPUM_2927 ENOG4105C3K feS assembly ATPase SufC BPUM_2930 ENOG4105D01 (LipO)protein BPUM_2931 ENOG4108UMI ABC transporter, permease BPUM_2932 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BPUM_2938 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BPUM_2939 ENOG41080E8 Transcriptional regulator, Spx MgsR family BPUM_2940 ENOG4105C1G acyl-Coa dehydrogenase BPUM_2941 ENOG4105CHU acetyl-coa acetyltransferase BPUM_2949 ENOG4105E0A ABC, transporter BPUM_2951 ENOG4105E1F short-chain dehydrogenase reductase BPUM_2952 ENOG4105C0H protease BPUM_2954 ENOG4105F3H Histidine kinase BPUM_2956 ENOG41067SE Tetr family transcriptional regulator BPUM_2957 ENOG4105C9Q fumarate hydratase class II BPUM_2963 ENOG4105WH1 Two component transcriptional regulator luxr family BPUM_2964 ENOG4105ENE Histidine kinase BPUM_2967 ENOG41087YS Phage shock protein A BPUM_2969 ENOG4108WBT adenosyltransferase BPUM_2971 ENOG4105CHR reductase BPUM_2972 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BPUM_2973 ENOG4107S2N Type III effector Hrp-dependent BPUM_2974 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BPUM_2977 ENOG4105C0A alcohol dehydrogenase BPUM_2978 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BPUM_2979 ENOG4105E0A ABC, transporter BPUM_2980 ENOG4105EHG Permease protein BPUM_2981 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BPUM_2984 ENOG4105CTX dehydratase BPUM_2985 ENOG4107QZW Altronate oxidoreductase BPUM_2986 ENOG4107KJX Transcriptional regulator BPUM_2987 ENOG4105D2H Uronic isomerase BPUM_2989 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BPUM_2990 ENOG4105E0A ABC, transporter BPUM_2991 ENOG4105EHG Permease protein BPUM_2992 ENOG4105DQ5 transport system permease protein BPUM_2995 ENOG4105D5Q Arginine ornithine antiporter BPUM_3000 ENOG4107K5X Membrane-bound metal-dependent hydrolase BPUM_3001 ENOG4107QZ2 Sulfatase BPUM_3002 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BPUM_3003 ENOG4105E0C molybdate abc transporter BPUM_3005 ENOG4105EVU fructokinase BPUM_3006 ENOG4107SUZ Sodium/hydrogen exchanger family BPUM_3007 ENOG4105EN6 Membrane BPUM_3009 ENOG4107ZQN disulfide bond BPUM_3010 ENOG4105C59 p-type ATPase BPUM_3011 ENOG4105DIK (ABC) transporter BPUM_3012 ENOG4105CC5 ABC transporter BPUM_3013 ENOG4105DSE periplasmic solute binding protein BPUM_3014 ENOG4105IIP Membrane BPUM_3015 ENOG4105W1N transcriptional regulator BPUM_3018 ENOG4108IJ0 Aspartate ammonia-lyase BPUM_3021 ENOG4105C59 p-type ATPase BPUM_3022 ENOG410681U heavy metal transport detoxification protein BPUM_3023 ENOG4105VPX protein, conserved in bacteria BPUM_3026 ENOG4105BZU Histidine kinase BPUM_3030 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BPUM_3031 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BPUM_3033 ENOG4105XZU Preprotein translocase, subunit SecG BPUM_3039 ENOG4105KVH Transcriptional regulator BPUM_3040 ENOG4105R40 Glycine betaine carnitine choline BPUM_3041 ENOG4108HQR Glycine betaine BPUM_3042 ENOG4105E90 ABC transporter BPUM_3043 ENOG4108IJ8 ABC transporter BPUM_3044 ENOG4107HG4 Transcriptional regulator BPUM_3045 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BPUM_3047 ENOG4108W0I acetyltransferase BPUM_3051 ENOG4105CJ1 ABC, transporter BPUM_3053 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BPUM_3055 ENOG4105CP7 Triose-phosphate isomerase BPUM_3056 ENOG4105BZA Phosphoglycerate kinase BPUM_3057 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BPUM_3060 ENOG4105C8Y Acetylornithine aminotransferase BPUM_3061 ENOG4108JUB Transcriptional regulator BPUM_3062 ENOG4105JXH GntR family transcriptional regulator BPUM_3063 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BPUM_3065 ENOG4107R73 Mate efflux family protein BPUM_3066 ENOG4108JQ7 (ABC) transporter BPUM_3067 ENOG4105C3U ABC transporter BPUM_3068 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BPUM_3069 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BPUM_3070 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BPUM_3071 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BPUM_3072 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BPUM_3073 ENOG4105D3Q Sugar transferase BPUM_3076 ENOG4107QRS glycosyltransferase group 2 family protein BPUM_3077 ENOG41068W6 Capsular polysaccharide biosynthesis protein BPUM_3078 ENOG4108KMV Glycosyl transferase (Group 1 BPUM_3079 ENOG4105K64 Glycosyl transferase, family 2 BPUM_3080 ENOG4108PQP glycosyl transferase group 1 BPUM_3082 ENOG4108QV3 biosynthesis protein BPUM_3083 ENOG4105HTX biosynthesis protein BPUM_3087 ENOG4105EHG Permease protein BPUM_3088 ENOG4105DQ5 transport system permease protein BPUM_3090 ENOG4108ZJ4 polysaccharide deacetylase BPUM_3092 ENOG4108S9F abc transporter, atp-binding protein BPUM_3095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BPUM_3096 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BPUM_3102 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BPUM_3103 ENOG4108URH decarboxylase BPUM_3104 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BPUM_3105 ENOG4105CHH sulfate transporter BPUM_3106 ENOG4108V2W Carbonate dehydratase BPUM_3108 ENOG4105C5I Dehydrogenase BPUM_3111 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BPUM_3112 ENOG4105KRI phosphocarrier protein (HPr BPUM_3113 ENOG4105CIE May be required for sporulation (By similarity) BPUM_3114 ENOG4105CHW UPF0052 protein BPUM_3115 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BPUM_3116 ENOG4108Z4K mutator MutT protein BPUM_3117 ENOG4105C3M thioredoxin reductase BPUM_3119 ENOG4105Z8B NlpC/P60 family BPUM_3121 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BPUM_3122 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BPUM_3123 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BPUM_3124 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BPUM_3125 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BPUM_3126 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BPUM_3127 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BPUM_3128 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BPUM_3131 ENOG4108RYK Nad-dependent epimerase dehydratase BPUM_3132 ENOG4108Z40 Transcriptional regulator BPUM_3133 ENOG4108S4C acetyltransferase BPUM_3134 ENOG4107XGZ Hydrolase BPUM_3135 ENOG4105HKU nucleoside recognition domain-containing protein BPUM_3136 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BPUM_3137 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BPUM_3138 ENOG4105CE4 GlcNAc 6-P deacetylase BPUM_3139 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BPUM_3140 ENOG4105FDP GntR family transcriptional regulator BPUM_3141 ENOG41088CQ domain protein BPUM_3142 ENOG41086DT Membrane protein of unknown function BPUM_3143 ENOG41067S9 phage shock protein C, PspC BPUM_3144 ENOG4108PY7 BPUM_3147 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BPUM_3148 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BPUM_3152 ENOG4105MKU Transcriptional regulator BPUM_3155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BPUM_3156 ENOG4105BZU Histidine kinase BPUM_3157 ENOG4105EDW glycosyl transferase, family 39 BPUM_3158 ENOG4105CKK Glycosyl transferase, family 2 BPUM_3161 ENOG4108RCM Nitroreductase BPUM_3162 ENOG4105KVH Transcriptional regulator BPUM_3166 ENOG4105CN1 protease BPUM_3169 ENOG4105CRP Part of the ABC transporter FtsEX involved in BPUM_3170 ENOG4105CAK Cell division ATP-binding protein ftsE BPUM_3177 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BPUM_3179 ENOG4105MS2 ribosomal subunit Interface protein BPUM_3180 ENOG4105C8Q Methyl-accepting chemotaxis BPUM_3183 ENOG4105MQ3 flagellar protein FliS BPUM_3184 ENOG4107RT6 flagellar hook-associated BPUM_3185 ENOG41083S7 flagellar protein FlaG BPUM_3186 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BPUM_3187 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BPUM_3188 ENOG4105MKD BPUM_3189 ENOG4105DTJ flagellar hook-associated protein BPUM_3190 ENOG4105E1Q flagellar hook-associated protein BPUM_3193 ENOG4105RU3 BPUM_3198 ENOG4105WH1 Two component transcriptional regulator luxr family BPUM_3199 ENOG4105BZU Histidine kinase BPUM_3200 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BPUM_3201 ENOG4108KGH TRANSCRIPTIONal BPUM_3202 ENOG4105ESV Glycosyl transferase, family 4 BPUM_3203 ENOG4107EF8 Glycosyl transferase (Group 1 BPUM_3206 ENOG4105QZI O-Antigen Polymerase BPUM_3207 ENOG4105C1B dTDP-glucose 4-6-dehydratase BPUM_3208 ENOG4105C6Y Udp-glucose 6-dehydrogenase BPUM_3209 ENOG4107RA4 Glycosyl transferase (Group 1 BPUM_3210 ENOG4105PSV Polysaccharide Biosynthesis Protein BPUM_3211 ENOG4105D3Q Sugar transferase BPUM_3214 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BPUM_3215 ENOG4105JFG SpoIID LytB domain protein BPUM_3218 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BPUM_3219 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BPUM_3220 ENOG4105EY8 ABC transporter BPUM_3222 ENOG4105K64 Glycosyl transferase, family 2 BPUM_3224 ENOG4105CPF Cell wall formation (By similarity) BPUM_3225 ENOG4107SJB teichoic acid biosynthesis BPUM_3227 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BPUM_3228 ENOG4107SJB teichoic acid biosynthesis BPUM_3229 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BPUM_3230 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BPUM_3232 ENOG4107RZX Teichoic acid biosynthesis protein BPUM_3234 ENOG4107SJB teichoic acid biosynthesis BPUM_3235 ENOG4105DG6 mannose-6-phosphate isomerase BPUM_3237 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BPUM_3238 ENOG4108JP0 extracellular solute-binding protein family 1 BPUM_3239 ENOG4105WH1 Two component transcriptional regulator luxr family BPUM_3240 ENOG4105C2F Histidine kinase BPUM_3242 ENOG4105I4A GCN5-related N-acetyltransferase BPUM_3243 ENOG4108UHU Aldolase BPUM_3244 ENOG4105D7K pfkb domain protein BPUM_3245 ENOG4108M60 Transcriptional regulator BPUM_3246 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BPUM_3247 ENOG4105CHR reductase BPUM_3250 ENOG4108NHD germination protein BPUM_3251 ENOG4107QJZ Glycosyl transferase, family 2 BPUM_3252 ENOG4105C54 Major Facilitator superfamily BPUM_3253 ENOG4108KGH TRANSCRIPTIONal BPUM_3254 ENOG4105J7I hydrolase BPUM_3255 ENOG4105K4H Nlp p60 protein BPUM_3257 ENOG4105PNM synthesis protein BPUM_3259 ENOG4105N98 Capsule biosynthesis protein capB BPUM_3263 ENOG4105ETE Transcriptional regulator (LacI family BPUM_3264 ENOG4108RVA ribokinase BPUM_3265 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BPUM_3266 ENOG4105C2J ABC transporter BPUM_3267 ENOG4105CNN ABC, transporter BPUM_3268 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BPUM_3269 ENOG4107XC4 flavin reductase domain protein, FMN-binding BPUM_3270 ENOG4107RSM transcriptional regulator BPUM_3272 ENOG4107FQX Alpha-acetolactate decarboxylase BPUM_3274 ENOG4105CAH Chromate BPUM_3275 ENOG4105FGV Chromate BPUM_3276 ENOG4105C6Y Udp-glucose 6-dehydrogenase BPUM_3278 ENOG4105KBK Zinc finger, swim domain protein BPUM_3279 ENOG4105C0D helicase BPUM_3280 ENOG4105BZU Histidine kinase BPUM_3281 ENOG410667J hydrolase BPUM_3285 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BPUM_3286 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BPUM_3288 ENOG4105CGA flagellar basal-body rod protein FlgG BPUM_3290 ENOG4105DFF Rod shape-determining protein mreb BPUM_3291 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BPUM_3292 ENOG4107MII Sugar-specific transcriptional regulator TrmB BPUM_3293 ENOG4105CZM Major Facilitator BPUM_3294 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BPUM_3295 ENOG41080V3 Major Facilitator superfamily BPUM_3296 ENOG4105EAB amino acid AbC transporter BPUM_3297 ENOG4105E5Q amino acid AbC transporter BPUM_3298 ENOG4105CDA abc transporter atp-binding protein BPUM_3300 ENOG4105BZU Histidine kinase BPUM_3302 ENOG4105FRN stage II sporulation protein BPUM_3303 ENOG4107TCE N-acetyltransferase BPUM_3310 ENOG4105WDJ 50S ribosomal protein L33 BPUM_3311 ENOG4105CKI cobalamin synthesis protein BPUM_3312 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BPUM_3315 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BPUM_3316 ENOG4105FCD Major Facilitator BPUM_3317 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit BPUM_3318 ENOG4108TF4 von Willebrand factor, type A BPUM_3321 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BPUM_3323 ENOG4106778 Protein of unknown function (DUF1146) BPUM_3325 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BPUM_3326 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BPUM_3327 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BPUM_3328 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BPUM_3332 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BPUM_3334 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BPUM_3335 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BPUM_3336 ENOG4108UIC UPF0340 protein BPUM_3337 ENOG4108YZG isomerase BPUM_3338 ENOG4107WAU Protein tyrosine phosphatase BPUM_3340 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BPUM_3342 ENOG4108ZXQ stage ii sporulation protein r BPUM_3344 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BPUM_3345 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BPUM_3347 ENOG4107TT2 Auxin Efflux Carrier BPUM_3348 ENOG4105C6K Malic enzyme BPUM_3349 ENOG4107104 thymidine kinase BPUM_3350 ENOG41082DI 50s ribosomal protein l31 BPUM_3353 ENOG4105CBT Fructose-1,6-bisphosphatase BPUM_3354 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BPUM_3357 ENOG4105D2N Aldolase BPUM_3358 ENOG410812K response regulator receiver protein BPUM_3360 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BPUM_3363 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BPUM_3370 ENOG4105C1G acyl-Coa dehydrogenase BPUM_3371 ENOG4105C1G acyl-Coa dehydrogenase BPUM_3372 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BPUM_3374 ENOG4105DF6 Fe-S oxidoreductase BPUM_3378 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BPUM_3379 ENOG4105BZ1 (ABC) transporter BPUM_3380 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BPUM_3383 ENOG4105C75 arginyL-tRNA synthetase BPUM_3384 ENOG410684U Domain of unknown function (DUF1934) BPUM_3386 ENOG4105CYW agmatinase BPUM_3387 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BPUM_3388 ENOG4105BZ4 penicillin-binding protein BPUM_3389 ENOG4108XFG YwhD family BPUM_3390 ENOG4108Z4T Peptidase M50 BPUM_3391 ENOG41069HH 4-oxalocrotonate tautomerase BPUM_3394 ENOG4105DCI Phosphohydrolase BPUM_3395 ENOG4105QAT UPF0741 protein BPUM_3396 ENOG4108VCI transcription factor, rsfa family BPUM_3398 ENOG4107QZ7 Cellulose synthase catalytic subunit BPUM_3400 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BPUM_3407 ENOG4107EV6 Inherit from COG: YD repeat protein BPUM_3413 ENOG4105JSC dimethylmenaquinone methyltransferase BPUM_3415 ENOG4108IJ2 phosphate acetyltransferase BPUM_3416 ENOG4107JTW chlorite dismutase BPUM_3417 ENOG4105F27 Major Facilitator BPUM_3419 ENOG4105FCW Major Facilitator superfamily BPUM_3420 ENOG41061WN bacilysin biosynthesis protein BPUM_3422 ENOG4105CHR reductase BPUM_3423 ENOG4108M32 ATP-grasp domain BPUM_3424 ENOG4105CHM Aminotransferase BPUM_3426 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BPUM_3427 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BPUM_3428 ENOG4105C1B dTDP-glucose 4-6-dehydratase BPUM_3429 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BPUM_3430 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BPUM_3431 ENOG4107TY6 Acylneuraminate cytidylyltransferase BPUM_3433 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BPUM_3434 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BPUM_3444 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BPUM_3445 ENOG4108RJ9 Glycosyl transferase, family 2 BPUM_3448 ENOG4105DWF phosphomethylpyrimidine kinase BPUM_3452 ENOG4105C5Y PTS System BPUM_3455 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BPUM_3457 ENOG4105DEN Luciferase family BPUM_3458 ENOG4108DBC nitroreductase BPUM_3461 ENOG41060D1 Quinol oxidase BPUM_3462 ENOG4105CCU oxidase (Subunit III) BPUM_3463 ENOG4105BZ9 Cytochrome C oxidase, subunit I BPUM_3464 ENOG4105E2S oxidase) subunit II BPUM_3467 ENOG4105CMR udp-glucose 4-epimerase BPUM_3468 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BPUM_3471 ENOG4105WH5 Teichoic acid glycosylation protein BPUM_3483 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BPUM_3484 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BPUM_3485 ENOG4105CMU LysR family (Transcriptional regulator BPUM_3487 ENOG41067MG lrgb family BPUM_3488 ENOG4105DR4 Methyltransferase BPUM_3490 ENOG4105CDA abc transporter atp-binding protein BPUM_3496 ENOG4105CNN ABC, transporter BPUM_3497 ENOG4105C2J ABC transporter BPUM_3498 ENOG4108QGH periplasmic BPUM_3499 ENOG4108M26 parallel beta-helix repeat protein BPUM_3500 ENOG4105CM2 brancheD-chain amino acid aminotransferase BPUM_3503 ENOG4105F8D glycoside hydrolase family 4 BPUM_3504 ENOG4105VCP PTS System BPUM_3505 ENOG4105CK1 PTS System BPUM_3506 ENOG4105VZJ PTS System BPUM_3507 ENOG4105EMD TRANSCRIPTIONal BPUM_3511 ENOG4107R37 Glutamate dehydrogenase BPUM_3515 ENOG4108J20 pectate lyase BPUM_3516 ENOG4108JJ8 (ABC) transporter BPUM_3517 ENOG4108JJ9 ABC, transporter BPUM_3518 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BPUM_3519 ENOG4105C4M (Ubiquinol oxidase) subunit I BPUM_3521 ENOG4105S6R Iron-hydroxamate transporter permease subunit BPUM_3523 ENOG4105KFN sortase, SrtB family BPUM_3528 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BPUM_3529 ENOG4105KVH Transcriptional regulator BPUM_3530 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BPUM_3531 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BPUM_3532 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BPUM_3535 ENOG4107BJW polysaccharide deacetylase BPUM_3536 ENOG4105VCP PTS System BPUM_3537 ENOG4105VZJ PTS System BPUM_3538 ENOG4105CS2 ec 3.2.1.21 BPUM_3540 ENOG4105CK1 PTS System BPUM_3541 ENOG4105EMD TRANSCRIPTIONal BPUM_3546 ENOG4105DFD Na H antiporter BPUM_3547 ENOG4108IJ0 Aspartate ammonia-lyase BPUM_3548 ENOG4105HDK L-asparaginase BPUM_3549 ENOG4108IMY Transcriptional regulator BPUM_3555 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BPUM_3558 ENOG4106KNT transcriptional regulator BPUM_3559 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BPUM_3561 ENOG4105C6Z Gluconate BPUM_3564 ENOG4105C19 ABC transporter BPUM_3565 ENOG4105CS2 ec 3.2.1.21 BPUM_3566 ENOG4105C5Y PTS System BPUM_3567 ENOG4105CID antiterminator BPUM_3569 ENOG4108XI2 Domain of unknown function (DUF1963) BPUM_3571 ENOG4108W7F transporter, permease BPUM_3572 ENOG4108JJB ABC transporter BPUM_3573 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BPUM_3574 ENOG4105ETU transcriptional activator (TenA BPUM_3580 ENOG4107G87 m6 family metalloprotease domain protein BPUM_3581 ENOG41067V3 Antibiotic biosynthesis monooxygenase BPUM_3582 ENOG4108TVJ Nitroreductase BPUM_3583 ENOG4105FS7 Transcriptional regulator BPUM_3585 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BPUM_3586 ENOG4105D9N nucleoside BPUM_3587 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BPUM_3588 ENOG4107RHR regulatoR BPUM_3590 ENOG4105EXC Acyl-transferase BPUM_3591 ENOG4105DXI Major Facilitator superfamily BPUM_3595 ENOG410667J hydrolase BPUM_3596 ENOG4105W1Y Transcriptional regulator BPUM_3597 ENOG4105EE0 oxidoreductase BPUM_3598 ENOG4105FKZ Methyl-accepting chemotaxis BPUM_3600 ENOG4105F1N DNA alkylation repair BPUM_3601 ENOG4105C6Z Gluconate BPUM_3602 ENOG4105CMG Carbohydrate kinase BPUM_3603 ENOG4106KNT transcriptional regulator BPUM_3611 ENOG4105DUM transcriptional regulator, lysR family BPUM_3613 ENOG4107FKK extracellular solute-binding protein family 1 BPUM_3615 ENOG4105EG2 ABC transporter, permease BPUM_3617 ENOG4105C4C beta-galactosidase BPUM_3620 ENOG4108TU7 Inherit from COG: (ABC) transporter BPUM_3621 ENOG4105CJ1 ABC, transporter BPUM_3623 ENOG4105CJ1 ABC, transporter BPUM_3629 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BPUM_3630 ENOG4105BZW Glycerate kinase BPUM_3631 ENOG4107QQ0 gntp family BPUM_3632 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BPUM_3633 ENOG4105YA8 Transcriptional regulator BPUM_3634 ENOG4107Y80 Major Facilitator superfamily BPUM_3636 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BPUM_3641 ENOG410780I phosphoprotein phosphatase activity BPUM_3642 ENOG4105CID antiterminator BPUM_3643 ENOG4105CS2 ec 3.2.1.21 BPUM_3644 ENOG4105C5Y PTS System BPUM_3652 ENOG4105C85 amino acid BPUM_3653 ENOG4105ETE Transcriptional regulator (LacI family BPUM_3656 ENOG4105E2X shikimate dehydrogenase BPUM_3662 ENOG4105CS2 ec 3.2.1.21 BPUM_3663 ENOG4108S3Y transcriptional regulator BPUM_3666 ENOG4105JAB phenazine biosynthesis protein, phzf family BPUM_3667 ENOG41080UQ Transcriptional regulator BPUM_3676 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BPUM_3677 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BPUM_3679 ENOG4108V7D UPF0397 protein BPUM_3683 ENOG4105WQG acetyltransferase BPUM_3684 ENOG4105C0H protease BPUM_3685 ENOG4105Q2H domain protein BPUM_3688 ENOG4105BZU Histidine kinase BPUM_3689 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BPUM_3690 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BPUM_3693 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BPUM_3694 ENOG4105ST3 Transcriptional regulator BPUM_3695 ENOG4106A3M Cytochrome p-450 BPUM_3696 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BPUM_3697 ENOG4105CDU Replicative dna helicase BPUM_3698 ENOG4106K80 BPUM_3700 ENOG410874W AraC family transcriptional regulator BPUM_3702 ENOG4108SA1 esterase BPUM_3704 ENOG4105DJ2 Major Facilitator Superfamily BPUM_3705 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BPUM_3706 ENOG4105BZR domain protein BPUM_3707 ENOG4108XMW Membrane BPUM_3708 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BPUM_3709 ENOG4108P49 AntiSigma factor BPUM_3710 ENOG4105JVQ RNA Polymerase BPUM_3712 ENOG4105CH6 catalase BPUM_3713 ENOG4105CS1 NAD(P)H quinone oxidoreductase BPUM_3714 ENOG4105FBA Phospholipase Carboxylesterase BPUM_3715 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BPUM_3716 ENOG4105E90 ABC transporter BPUM_3717 ENOG4108IJ8 ABC transporter BPUM_3718 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BPUM_3719 ENOG4108UUM single-stranded DNA-binding protein BPUM_3720 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BPUM_3721 ENOG4105C3G gtp-binding protein BPUM_3722 ENOG4105VDK protein, conserved in bacteria BPUM_3726 ENOG4108ZDA Sporulation protein YyaC BPUM_3727 ENOG4105FA0 parb-like partition protein BPUM_3728 ENOG4107QJE Chromosome Partitioning Protein BPUM_3731 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BPUM_3732 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BPUM_3733 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BPUM_3735 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BPUM_3736 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)