locus-tag	class	description
UP15_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UP15_00010	COG0592	DNA-directed DNA polymerase activity
UP15_00015	COG2501	S4 domain
UP15_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UP15_00030	COG0187	DNA topoisomerase II activity
UP15_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP15_00070	COG0516	GMP reductase activity
UP15_00070	COG0517	IMP dehydrogenase activity
UP15_00075	COG1686	Belongs to the peptidase S11 family
UP15_00085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP15_00090	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UP15_00095	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
UP15_00100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UP15_00105	COG0840	transmembrane signaling receptor activity
UP15_00120	COG1428	Deoxynucleoside kinase
UP15_00125	COG1428	Deoxynucleoside kinase
UP15_00130	COG1388	LysM domain
UP15_00130	COG3858	chitin binding
UP15_00135	COG1335	isochorismatase
UP15_00140	COG0590	tRNA wobble adenosine to inosine editing
UP15_00145	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UP15_00150	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UP15_00155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UP15_00200	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
UP15_00205	COG3853	Toxic anion resistance protein (TelA)
UP15_00210	COG1982	Orn Lys Arg decarboxylase major
UP15_00215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UP15_00220	COG3870	Protein conserved in bacteria
UP15_00225	COG1728	Protein conserved in bacteria
UP15_00230	COG0470	DNA polymerase III
UP15_00235	COG1774	PSP1 C-terminal conserved region
UP15_00240	COG4467	Involved in initiation control of chromosome replication
UP15_00245	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UP15_00250	COG2827	Endonuclease containing a URI domain
UP15_00255	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UP15_00260	COG2002	toxin-antitoxin pair type II binding
UP15_00265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP15_00265	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP15_00270	COG0084	hydrolase, TatD family'
UP15_00275	COG3583	domain protein
UP15_00275	COG3584	3D domain protein
UP15_00280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UP15_00285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UP15_00295	COG4466	Protein conserved in bacteria
UP15_00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
UP15_00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP15_00315	COG0251	oxidation-reduction process
UP15_00320	COG2088	sporulation resulting in formation of a cellular spore
UP15_00330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UP15_00335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UP15_00340	COG0193	aminoacyl-tRNA hydrolase activity
UP15_00350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UP15_00355	COG2002	toxin-antitoxin pair type II binding
UP15_00360	COG2244	polysaccharide biosynthetic process
UP15_00365	COG3956	TIGRFAM MazG family protein
UP15_00370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UP15_00385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
UP15_00390	COG1098	S1 RNA binding domain
UP15_00405	COG2208	phosphoserine phosphatase activity
UP15_00410	COG2304	oxidoreductase activity
UP15_00415	COG0515	serine threonine protein kinase
UP15_00420	COG0037	tRNA processing
UP15_00430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UP15_00435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UP15_00440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UP15_00445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP15_00450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP15_00455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UP15_00460	COG0512	Glutamine amidotransferase of anthranilate synthase
UP15_00465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP15_00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UP15_00475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UP15_00480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UP15_00485	COG1396	sequence-specific DNA binding
UP15_00490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP15_00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UP15_00575	COG4463	regulation of RNA biosynthetic process
UP15_00580	COG3880	PFAM UvrB UvrC protein
UP15_00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
UP15_00590	COG0542	response to heat
UP15_00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UP15_00600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
UP15_00605	COG4956	integral membrane protein (PIN domain superfamily)
UP15_00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UP15_00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UP15_00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UP15_00625	COG1045	serine acetyltransferase
UP15_00630	COG0215	cysteine-tRNA ligase activity
UP15_00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
UP15_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP15_00645	COG3688	RNA-binding protein containing a PIN domain
UP15_00650	COG1595	DNA-templated transcription, initiation
UP15_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP15_00660	COG0250	Participates in transcription elongation, termination and antitermination
UP15_00665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UP15_00670	COG0081	regulation of translation
UP15_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UP15_00680	COG0222	ribosome binding
UP15_00685	COG2813	Specifically methylates the guanine in position
UP15_00690	COG0085	RNA polymerase activity
UP15_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UP15_00700	COG1358	cellular component organization or biogenesis
UP15_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UP15_00710	COG0049	tRNA binding
UP15_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UP15_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UP15_00725	COG0596	Alpha beta hydrolase
UP15_00730	COG0051	transcription antitermination factor activity, RNA binding
UP15_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UP15_00740	COG0088	Forms part of the polypeptide exit tunnel
UP15_00745	COG0089	rRNA binding
UP15_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UP15_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UP15_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UP15_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UP15_00770	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UP15_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
UP15_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UP15_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UP15_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UP15_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UP15_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP15_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UP15_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UP15_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UP15_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UP15_00825	COG1841	ribosomal large subunit assembly
UP15_00830	COG0200	Binds to the 23S rRNA
UP15_00835	COG0201	protein transport
UP15_00840	COG0563	adenylate kinase activity
UP15_00845	COG0024	Methionine aminopeptidase
UP15_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UP15_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UP15_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UP15_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UP15_00870	COG0202	RNA polymerase activity
UP15_00875	COG0203	ribosomal protein L17
UP15_00880	COG1122	ATPase activity
UP15_00885	COG1122	ATPase activity
UP15_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP15_00895	COG0101	tRNA pseudouridine synthase activity
UP15_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UP15_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UP15_00910	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP15_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP15_00940	COG0489	protein tyrosine kinase activity
UP15_00950	COG2194	sulfuric ester hydrolase activity
UP15_00955	COG0726	polysaccharide deacetylase
UP15_00985	COG0659	secondary active sulfate transmembrane transporter activity
UP15_00990	COG0385	Bile acid
UP15_00995	COG3876	Protein conserved in bacteria
UP15_01000	COG1472	Belongs to the glycosyl hydrolase 3 family
UP15_01005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UP15_01010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_01010	COG1263	PTS System
UP15_01015	COG1737	Transcriptional regulator
UP15_01020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UP15_01055	COG1595	DNA-templated transcription, initiation
UP15_01060	COG5662	AntiSigma factor
UP15_01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UP15_01070	COG4856	YbbR-like protein
UP15_01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP15_01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UP15_01095	COG1131	(ABC) transporter
UP15_01105	COG1136	(ABC) transporter
UP15_01115	COG1695	Transcriptional regulator
UP15_01135	COG2311	Membrane
UP15_01155	COG1476	TRANSCRIPTIONal
UP15_01165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UP15_01170	COG2207	Transcriptional regulator
UP15_01175	COG1309	transcriptional regulator
UP15_01190	COG1113	amino acid transport
UP15_01195	COG0584	glycerophosphoryl diester phosphodiesterase
UP15_01200	COG2271	Major facilitator Superfamily
UP15_01210	COG1331	Highly conserved protein containing a thioredoxin domain
UP15_01220	COG0232	Belongs to the dGTPase family. Type 2 subfamily
UP15_01225	COG1331	Highly conserved protein containing a thioredoxin domain
UP15_01235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP15_01255	COG0640	Transcriptional regulator
UP15_01270	COG1937	Protein conserved in bacteria
UP15_01275	COG2210	Belongs to the sulfur carrier protein TusA family
UP15_01285	COG0425	Belongs to the sulfur carrier protein TusA family
UP15_01285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP15_01290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP15_01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP15_01295	COG0425	Belongs to the sulfur carrier protein TusA family
UP15_01300	COG0730	response to heat
UP15_01305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP15_01310	COG2814	Major facilitator Superfamily
UP15_01325	COG1846	Transcriptional regulator
UP15_01335	COG1683	Conserved Protein
UP15_01345	COG0656	L-ascorbic acid biosynthetic process
UP15_01350	COG0371	Dehydrogenase
UP15_01360	COG0531	amino acid
UP15_01370	COG3711	transcriptional antiterminator
UP15_01375	COG2190	(PTS) system
UP15_01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_01375	COG1263	PTS System
UP15_01380	COG2723	6-phospho-beta-galactosidase activity
UP15_01395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_01395	COG3711	transcriptional antiterminator
UP15_01400	COG1940	carbohydrate kinase activity
UP15_01405	COG0383	alpha-mannosidase activity
UP15_01410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_01415	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_01420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_01420	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_01425	COG1404	Belongs to the peptidase S8 family
UP15_01440	COG0833	amino acid
UP15_01445	COG2040	homocysteine
UP15_01450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP15_01455	COG1695	Transcriptional regulator
UP15_01465	COG2814	Major facilitator Superfamily
UP15_01485	COG1404	Belongs to the peptidase S8 family
UP15_01495	COG1309	transcriptional regulator
UP15_01500	COG1917	Cupin 2, conserved barrel domain protein
UP15_01505	COG1063	alcohol dehydrogenase
UP15_01510	COG1846	Transcriptional regulator
UP15_01515	COG0318	PFAM AMP-dependent synthetase and ligase
UP15_01520	COG0531	amino acid
UP15_01530	COG0596	Alpha beta hydrolase
UP15_01535	COG1115	amino acid carrier protein
UP15_01540	COG2066	Belongs to the glutaminase family
UP15_01545	COG4191	Histidine kinase
UP15_01550	COG0784	Response regulator, receiver
UP15_01555	COG3012	SEC-C Motif Domain Protein
UP15_01555	COG1405	negative regulation of cell septum assembly
UP15_01570	COG0667	Aldo Keto reductase
UP15_01575	COG3290	protein histidine kinase activity
UP15_01580	COG3279	Response regulator of the LytR AlgR family
UP15_01585	COG4555	ABC transporter
UP15_01590	COG1668	transmembrane transport
UP15_01610	COG3773	Cell wall hydrolase
UP15_01615	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP15_01630	COG2310	stress, protein
UP15_01635	COG2310	stress, protein
UP15_01640	COG2310	stress, protein
UP15_01645	COG0861	Integral membrane protein TerC family
UP15_01675	COG3853	Toxic anion resistance protein (TelA)
UP15_01680	COG4175	Glycine betaine
UP15_01680	COG0517	IMP dehydrogenase activity
UP15_01685	COG4176	ABC-type proline glycine betaine transport system permease component
UP15_01690	COG2113	Glycine betaine
UP15_01705	COG1473	amidohydrolase
UP15_01710	COG1288	antiporter activity
UP15_01715	COG0039	L-malate dehydrogenase activity
UP15_01720	COG1620	l-lactate permease
UP15_01725	COG1609	Transcriptional regulator
UP15_01730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UP15_01735	COG0561	phosphatase activity
UP15_01740	COG0673	inositol 2-dehydrogenase activity
UP15_01745	COG0738	Major facilitator superfamily
UP15_01750	COG1280	lysine exporter protein (LysE YggA)
UP15_01765	COG3403	YqcI/YcgG family
UP15_01770	COG1113	amino acid transport
UP15_01775	COG3665	Urea carboxylase-associated protein
UP15_01780	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UP15_01790	COG1012	belongs to the aldehyde dehydrogenase family
UP15_01795	COG0710	3-dehydroquinate dehydratase activity
UP15_01800	COG0028	Belongs to the TPP enzyme family
UP15_01810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UP15_01815	COG2271	Major facilitator Superfamily
UP15_01825	COG1414	Transcriptional regulator
UP15_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UP15_01835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP15_01845	COG0477	Major facilitator Superfamily
UP15_01850	COG2226	methyltransferase
UP15_01855	COG0583	DNA-binding transcription factor activity
UP15_01860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP15_01865	COG3458	cephalosporin-C deacetylase activity
UP15_01875	COG3541	Predicted nucleotidyltransferase
UP15_01880	COG0506	proline dehydrogenase activity
UP15_01885	COG1012	belongs to the aldehyde dehydrogenase family
UP15_01890	COG2508	Transcriptional regulator
UP15_01895	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP15_01900	COG0765	amino acid transport
UP15_01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_01915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP15_01920	COG1522	sequence-specific DNA binding
UP15_01925	COG2746	aminoglycoside 3-N-acetyltransferase activity
UP15_01935	COG0840	transmembrane signaling receptor activity
UP15_01935	COG3290	protein histidine kinase activity
UP15_01940	COG3209	COG3209 Rhs family protein
UP15_01965	COG3842	ATPase activity
UP15_01970	COG1176	ABC-type spermidine putrescine transport system, permease component I
UP15_01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP15_01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP15_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP15_02005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
UP15_02010	COG0697	spore germination
UP15_02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP15_02030	COG2364	Membrane
UP15_02035	COG0737	Belongs to the 5'-nucleotidase family
UP15_02040	COG3764	Sortase (surface protein transpeptidase)
UP15_02045	COG2002	toxin-antitoxin pair type II binding
UP15_02050	COG1126	abc transporter atp-binding protein
UP15_02055	COG0765	amino acid transport
UP15_02060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_02065	COG0412	Dienelactone hydrolase
UP15_02070	COG0833	amino acid
UP15_02075	COG3104	oligopeptide transport
UP15_02080	COG5434	Belongs to the glycosyl hydrolase 28 family
UP15_02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_02100	COG0765	amino acid transport
UP15_02105	COG1126	abc transporter atp-binding protein
UP15_02115	COG2079	MmgE PrpD family protein
UP15_02125	COG0745	RESPONSE REGULATOR receiver
UP15_02130	COG5002	protein histidine kinase activity
UP15_02130	COG3850	Histidine kinase
UP15_02135	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_02140	COG0527	aspartate kinase activity
UP15_02145	COG2814	Major facilitator Superfamily
UP15_02150	COG1309	transcriptional regulator
UP15_02160	COG0640	Transcriptional regulator
UP15_02170	COG0583	DNA-binding transcription factor activity
UP15_02175	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP15_02180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UP15_02185	COG0531	amino acid
UP15_02190	COG1012	belongs to the aldehyde dehydrogenase family
UP15_02195	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP15_02200	COG4549	nuclear export factor GLE1
UP15_02205	COG2372	response to copper ion
UP15_02205	COG1276	copper resistance
UP15_02210	COG2213	PTS system mannitol-specific
UP15_02215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_02220	COG0246	Mannitol dehydrogenase
UP15_02225	COG0840	transmembrane signaling receptor activity
UP15_02260	COG0346	lactoylglutathione lyase activity
UP15_02270	COG0561	phosphatase activity
UP15_02300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UP15_02305	COG1914	H( )-stimulated, divalent metal cation uptake system
UP15_02310	COG4336	lyase activity
UP15_02315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UP15_02320	COG1984	allophanate hydrolase subunit 2
UP15_02325	COG1414	Transcriptional regulator
UP15_02330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP15_02335	COG2755	lipolytic protein G-D-S-L family
UP15_02345	COG3711	transcriptional antiterminator
UP15_02350	COG2226	methyltransferase
UP15_02355	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_02360	COG3871	stress protein (general stress protein 26)
UP15_02380	COG2814	Major facilitator Superfamily
UP15_02385	COG1802	Transcriptional regulator
UP15_02390	COG2207	Transcriptional regulator
UP15_02390	COG1917	Cupin 2, conserved barrel domain protein
UP15_02395	COG0697	spore germination
UP15_02400	COG0473	3-isopropylmalate dehydrogenase activity
UP15_02405	COG0551	DNA topoisomerase type I activity
UP15_02405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP15_02410	COG3344	reverse transcriptase
UP15_02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
UP15_02425	COG3706	GGDEF domain
UP15_02430	COG5298	Protein conserved in bacteria
UP15_02435	COG1215	transferase activity, transferring glycosyl groups
UP15_02445	COG0531	amino acid
UP15_02450	COG0028	Belongs to the TPP enzyme family
UP15_02480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP15_02485	COG1914	H( )-stimulated, divalent metal cation uptake system
UP15_02490	COG2261	transglycosylase associated protein
UP15_02495	COG2217	Heavy metal translocating P-type atpase
UP15_02500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UP15_02505	COG3290	protein histidine kinase activity
UP15_02510	COG4565	transcriptional regulatory protein
UP15_02515	COG1301	dicarboxylic acid transport
UP15_02520	COG0628	permease
UP15_02525	COG1301	dicarboxylic acid transport
UP15_02530	COG1131	(ABC) transporter
UP15_02535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP15_02545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_02550	COG1181	Belongs to the D-alanine--D-alanine ligase family
UP15_02555	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UP15_02570	COG0513	Belongs to the DEAD box helicase family
UP15_02575	COG3402	PFAM membrane-flanked domain
UP15_02580	COG3428	Bacterial PH domain
UP15_02585	COG0705	Rhomboid family
UP15_02590	COG0736	holo-[acyl-carrier-protein] synthase activity
UP15_02595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UP15_02600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UP15_02605	COG0864	Transcriptional regulator
UP15_02610	COG2337	Toxic component of a toxin-antitoxin (TA) module
UP15_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_02625	COG2172	sigma factor antagonist activity
UP15_02630	COG2208	phosphoserine phosphatase activity
UP15_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_02640	COG2172	sigma factor antagonist activity
UP15_02645	COG1191	sigma factor activity
UP15_02650	COG2208	phosphoserine phosphatase activity
UP15_02655	COG2183	response to ionizing radiation
UP15_02660	COG3091	SprT-like family
UP15_02665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP15_02670	COG0022	dehydrogenase e1 component
UP15_02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP15_02680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP15_02685	COG3284	Transcriptional regulator
UP15_02725	COG0433	COG0433 Predicted ATPase
UP15_02740	COG1404	Belongs to the peptidase S8 family
UP15_02745	COG1278	Cold shock
UP15_02750	COG1329	Transcriptional regulator
UP15_02755	COG1064	alcohol dehydrogenase
UP15_02760	COG0789	Transcriptional regulator
UP15_02775	COG0477	Major facilitator Superfamily
UP15_02795	COG4221	oxidoreductase activity
UP15_02805	COG0252	asparaginase activity
UP15_02815	COG2801	Transposase and inactivated derivatives
UP15_02840	COG2814	Major facilitator Superfamily
UP15_02845	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
UP15_02850	COG2409	Drug exporters of the RND superfamily
UP15_02855	COG4585	Histidine kinase
UP15_02860	COG2197	response regulator
UP15_02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP15_02905	COG1309	transcriptional regulator
UP15_02910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP15_02915	COG1846	Transcriptional regulator
UP15_02920	COG0778	Nitroreductase
UP15_02935	COG1396	sequence-specific DNA binding
UP15_02945	COG0456	acetyltransferase
UP15_02965	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UP15_02970	COG0697	spore germination
UP15_02980	COG1301	dicarboxylic acid transport
UP15_03020	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
UP15_03025	COG0802	atpase or kinase
UP15_03030	COG1214	PFAM Peptidase M22, glycoprotease
UP15_03035	COG0456	acetyltransferase
UP15_03040	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UP15_03045	COG0488	(ABC) transporter
UP15_03050	COG0315	cyclic pyranopterin monophosphate synthase activity
UP15_03055	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UP15_03060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP15_03065	COG0805	protein transport
UP15_03080	COG1266	CAAX protease self-immunity
UP15_03085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UP15_03090	COG0459	protein refolding
UP15_03095	COG1846	Transcriptional regulator
UP15_03100	COG0456	acetyltransferase
UP15_03105	COG2808	Putative FMN-binding domain
UP15_03135	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UP15_03140	COG0823	Involved in the tonB-independent uptake of proteins
UP15_03150	COG2132	Multicopper oxidase
UP15_03155	COG1113	amino acid transport
UP15_03160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP15_03165	COG0714	Associated with various cellular activities
UP15_03170	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
UP15_03175	COG1305	Transglutaminase-like
UP15_03180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UP15_03180	COG0519	Catalyzes the synthesis of GMP from XMP
UP15_03200	COG1674	ftsk spoiiie
UP15_03230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UP15_03240	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP15_03245	COG2207	Transcriptional regulator
UP15_03265	COG1404	Belongs to the peptidase S8 family
UP15_03285	COG1595	DNA-templated transcription, initiation
UP15_03295	COG2814	Major facilitator Superfamily
UP15_03300	COG0583	DNA-binding transcription factor activity
UP15_03305	COG2252	PERMEase
UP15_03310	COG5583	Uncharacterized small protein (DUF2292)
UP15_03315	COG3064	Membrane
UP15_03320	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
UP15_03330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UP15_03335	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UP15_03340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UP15_03345	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UP15_03350	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UP15_03355	COG0047	phosphoribosylformylglycinamidine synthase activity
UP15_03360	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UP15_03365	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UP15_03370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UP15_03375	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UP15_03380	COG0138	bifunctional purine biosynthesis protein purh
UP15_03385	COG0151	Belongs to the GarS family
UP15_03405	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP15_03410	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP15_03415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP15_03420	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP15_03430	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UP15_03435	COG4496	protein, YerC YecD
UP15_03445	COG0069	glutamate synthase activity
UP15_03460	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
UP15_03465	COG0210	DNA helicase
UP15_03470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UP15_03475	COG4851	CamS sex pheromone cAM373 precursor
UP15_03490	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UP15_03505	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP15_03520	COG1960	acyl-CoA dehydrogenase activity
UP15_03530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP15_03550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP15_03555	COG1785	Belongs to the alkaline phosphatase family
UP15_03560	COG1285	pathogenesis
UP15_03565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP15_03570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP15_03575	COG0154	amidase activity
UP15_03580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP15_03585	COG1309	transcriptional regulator
UP15_03590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP15_03600	COG1597	lipid kinase activity
UP15_03605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UP15_03620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP15_03635	COG1959	2 iron, 2 sulfur cluster binding
UP15_03640	COG0492	ferredoxin-NADP+ reductase activity
UP15_03655	COG1486	melibiose metabolic process
UP15_03665	COG2211	Major facilitator Superfamily
UP15_03690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
UP15_03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP15_03700	COG1442	glycosyl transferase family 8
UP15_03705	COG1216	Glycosyl transferase, family 2
UP15_03710	COG1442	glycosyl transferase family 8
UP15_03715	COG2223	nitrite transmembrane transporter activity
UP15_03725	COG0471	metal ion transport
UP15_03740	COG0071	Belongs to the small heat shock protein (HSP20) family
UP15_03755	COG0531	amino acid
UP15_03760	COG0463	Glycosyl transferase, family 2
UP15_03760	COG0457	Tetratricopeptide repeat
UP15_03765	COG0488	(ABC) transporter
UP15_03775	COG1469	GTP cyclohydrolase I activity
UP15_03780	COG0789	Transcriptional regulator
UP15_03785	COG2814	Major facilitator Superfamily
UP15_03790	COG0488	(ABC) transporter
UP15_03795	COG0513	Belongs to the DEAD box helicase family
UP15_03800	COG2130	NADP-dependent
UP15_03820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP15_03820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP15_03825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UP15_03835	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP15_03835	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP15_03860	COG3290	protein histidine kinase activity
UP15_03865	COG4565	transcriptional regulatory protein
UP15_03870	COG3181	Tripartite tricarboxylate transporter family receptor
UP15_03875	COG2851	Citrate transporter
UP15_03885	COG3479	Phenolic acid decarboxylase
UP15_03890	COG1695	Transcriptional regulator
UP15_03895	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
UP15_03905	COG1254	Belongs to the acylphosphatase family
UP15_03910	COG2258	MOSC domain
UP15_03915	COG0024	Methionine aminopeptidase
UP15_03920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_03920	COG1263	PTS System
UP15_03925	COG3739	integral membrane protein
UP15_03940	COG1368	sulfuric ester hydrolase activity
UP15_03945	COG0076	glutamate decarboxylase activity
UP15_03960	COG1263	PTS System
UP15_03960	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_03965	COG0366	Alpha amylase catalytic
UP15_03970	COG2188	Transcriptional regulator
UP15_03980	COG0737	Belongs to the 5'-nucleotidase family
UP15_03985	COG0693	protein deglycase activity
UP15_03990	COG4840	Belongs to the UPF0435 family
UP15_03995	COG1115	amino acid carrier protein
UP15_04000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP15_04005	COG4980	gas vesicle protein
UP15_04010	COG1295	ribonuclease BN
UP15_04015	COG0477	Major facilitator Superfamily
UP15_04025	COG0387	Pfam Sodium calcium exchanger
UP15_04035	COG0217	transcriptional regulatory protein
UP15_04045	COG0668	transmembrane transport
UP15_04050	COG0535	radical SAM domain protein
UP15_04060	COG0726	polysaccharide deacetylase
UP15_04070	COG0598	Magnesium transport protein CorA
UP15_04080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UP15_04085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UP15_04115	COG0789	Transcriptional regulator
UP15_04120	COG2814	Major facilitator Superfamily
UP15_04170	COG2076	Multidrug Resistance protein
UP15_04175	COG2076	Multidrug Resistance protein
UP15_04180	COG1309	transcriptional regulator
UP15_04190	COG4637	Psort location Cytoplasmic, score
UP15_04195	COG2755	lipolytic protein G-D-S-L family
UP15_04200	COG0492	ferredoxin-NADP+ reductase activity
UP15_04205	COG2169	Transcriptional regulator
UP15_04210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
UP15_04215	COG1132	(ABC) transporter
UP15_04220	COG1742	UPF0060 membrane protein
UP15_04225	COG1595	DNA-templated transcription, initiation
UP15_04245	COG2318	DinB family
UP15_04255	COG1846	Transcriptional regulator
UP15_04260	COG0392	lysyltransferase activity
UP15_04260	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
UP15_04280	COG0778	Nitroreductase
UP15_04290	COG1090	epimerase
UP15_04295	COG2137	regulation of response to DNA damage stimulus
UP15_04315	COG0463	Glycosyl transferase, family 2
UP15_04320	COG4485	Bacterial membrane protein, YfhO
UP15_04340	COG2140	Oxalate decarboxylase
UP15_04345	COG1191	sigma factor activity
UP15_04355	COG1988	membrane-bound metal-dependent
UP15_04360	COG1194	a g-specific adenine glycosylase
UP15_04370	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_04385	COG3557	Belongs to the UPF0374 family
UP15_04390	COG1132	(ABC) transporter
UP15_04395	COG0444	Belongs to the ABC transporter superfamily
UP15_04400	COG4608	Belongs to the ABC transporter superfamily
UP15_04405	COG0747	negative chemotaxis
UP15_04420	COG4129	membrane
UP15_04425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP15_04430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UP15_04435	COG0735	belongs to the Fur family
UP15_04585	COG1368	sulfuric ester hydrolase activity
UP15_04590	COG0681	Belongs to the peptidase S26 family
UP15_04610	COG1116	anion transmembrane transporter activity
UP15_04615	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP15_04620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP15_04625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP15_04635	COG1131	(ABC) transporter
UP15_04665	COG3382	B3 4 domain protein
UP15_04670	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UP15_04680	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UP15_04685	COG2766	serine protein kinase
UP15_04690	COG2718	Belongs to the UPF0229 family
UP15_04695	COG1566	PFAM secretion protein HlyD family protein
UP15_04700	COG2814	Major facilitator Superfamily
UP15_04705	COG0655	NAD(P)H dehydrogenase (quinone) activity
UP15_04715	COG1278	Cold shock
UP15_04745	COG5577	PFAM Coat F domain
UP15_04750	COG5002	protein histidine kinase activity
UP15_04755	COG1525	nuclease
UP15_04755	COG0737	Belongs to the 5'-nucleotidase family
UP15_04755	COG4085	toxin activity
UP15_04760	COG3764	Sortase (surface protein transpeptidase)
UP15_04765	COG0564	pseudouridine synthase activity
UP15_04775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UP15_04780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP15_04780	COG3153	acetyltransferase
UP15_04800	COG3835	regulator
UP15_04805	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP15_04810	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
UP15_04815	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UP15_04820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UP15_04825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UP15_04830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP15_04835	COG4585	Histidine kinase
UP15_04835	COG2203	Gaf domain
UP15_04840	COG2197	response regulator
UP15_04855	COG0753	catalase activity
UP15_04860	COG1959	2 iron, 2 sulfur cluster binding
UP15_04865	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UP15_04865	COG1017	nitric oxide dioxygenase activity
UP15_04870	COG2719	SpoVR family
UP15_04875	COG1785	Belongs to the alkaline phosphatase family
UP15_04880	COG1388	LysM domain
UP15_04880	COG0791	NLP P60 protein
UP15_04895	COG1595	DNA-templated transcription, initiation
UP15_04900	COG0204	Acyl-transferase
UP15_04905	COG1253	flavin adenine dinucleotide binding
UP15_04910	COG0789	Transcriptional regulator
UP15_04915	COG1253	flavin adenine dinucleotide binding
UP15_04930	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UP15_04935	COG0584	glycerophosphoryl diester phosphodiesterase
UP15_04940	COG0668	transmembrane transport
UP15_04945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
UP15_04950	COG0726	polysaccharide deacetylase
UP15_04955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP15_04960	COG0589	response to stress
UP15_04965	COG1132	(ABC) transporter
UP15_04970	COG1132	(ABC) transporter
UP15_04980	COG0702	epimerase
UP15_04990	COG3842	ATPase activity
UP15_04995	COG2508	Transcriptional regulator
UP15_05005	COG0189	ligase activity
UP15_05010	COG0189	ligase activity
UP15_05015	COG4399	Belongs to the UPF0754 family
UP15_05020	COG3679	Belongs to the UPF0342 family
UP15_05025	COG0561	phosphatase activity
UP15_05030	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP15_05040	COG0475	glutathione-regulated potassium exporter activity
UP15_05045	COG0490	domain, Protein
UP15_05055	COG1024	Enoyl-CoA hydratase
UP15_05065	COG0420	3'-5' exonuclease activity
UP15_05070	COG4717	serine-type aminopeptidase activity
UP15_05075	COG3481	metal-dependent phosphohydrolase, HD sub domain
UP15_05085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP15_05110	COG1846	Transcriptional regulator
UP15_05115	COG4980	gas vesicle protein
UP15_05130	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UP15_05135	COG0537	adenosine 5'-monophosphoramidase activity
UP15_05140	COG1131	(ABC) transporter
UP15_05145	COG4473	ABC transporter
UP15_05155	COG1473	amidohydrolase
UP15_05165	COG2329	Antibiotic biosynthesis monooxygenase
UP15_05170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP15_05175	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UP15_05190	COG1309	transcriptional regulator
UP15_05195	COG1511	domain protein
UP15_05205	COG1363	Peptidase, m42
UP15_05210	COG1301	dicarboxylic acid transport
UP15_05215	COG1234	tRNA 3'-trailer cleavage
UP15_05220	COG0095	Lipoate-protein ligase
UP15_05225	COG0318	PFAM AMP-dependent synthetase and ligase
UP15_05235	COG0501	Belongs to the peptidase M48B family
UP15_05240	COG1404	Belongs to the peptidase S8 family
UP15_05245	COG0406	alpha-ribazole phosphatase activity
UP15_05250	COG0840	transmembrane signaling receptor activity
UP15_05255	COG0723	plastoquinol--plastocyanin reductase activity
UP15_05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP15_05260	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_05270	COG4903	ComK protein
UP15_05285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP15_05290	COG2814	Major facilitator Superfamily
UP15_05295	COG2732	(Barnase) inhibitor
UP15_05300	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_05305	COG4605	iron ion homeostasis
UP15_05310	COG4604	ABC transporter, ATP-binding protein
UP15_05315	COG4607	ABC-type enterochelin transport system periplasmic component
UP15_05320	COG1316	TRANSCRIPTIONal
UP15_05335	COG0398	Pfam SNARE associated Golgi protein
UP15_05340	COG0681	Belongs to the peptidase S26 family
UP15_05345	COG3180	Ammonia monooxygenase
UP15_05360	COG2259	Doxx family
UP15_05365	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
UP15_05370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
UP15_05375	COG1074	ATP-dependent DNA helicase activity
UP15_05380	COG0420	3'-5' exonuclease activity
UP15_05385	COG0419	ATPase involved in DNA repair
UP15_05390	COG1403	HNH endonuclease
UP15_05430	COG5337	Spore coat protein CotH
UP15_05440	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP15_05455	COG0367	asparagine synthase
UP15_05470	COG1562	ergosterol biosynthetic process
UP15_05475	COG0534	Mate efflux family protein
UP15_05480	COG2207	Transcriptional regulator
UP15_05480	COG1917	Cupin 2, conserved barrel domain protein
UP15_05505	COG0076	glutamate decarboxylase activity
UP15_05540	COG0646	methionine synthase
UP15_05540	COG1410	methionine synthase
UP15_05545	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UP15_05545	COG0646	methionine synthase
UP15_05550	COG1666	GTP binding
UP15_05555	COG2996	Protein conserved in bacteria
UP15_05565	COG0840	transmembrane signaling receptor activity
UP15_05570	COG1307	EDD domain protein, DegV family
UP15_05575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP15_05595	COG0561	phosphatase activity
UP15_05600	COG1073	alpha beta
UP15_05605	COG2151	metal-sulfur cluster biosynthetic enzyme
UP15_05610	COG0277	FAD linked oxidase domain protein
UP15_05615	COG2271	Major facilitator Superfamily
UP15_05620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UP15_05630	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UP15_05635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UP15_05640	COG0505	Belongs to the CarA family
UP15_05645	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UP15_05650	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UP15_05660	COG2814	Major facilitator Superfamily
UP15_05670	COG2267	carboxylic ester hydrolase activity
UP15_05680	COG1744	ABC transporter substrate-binding protein PnrA-like
UP15_05695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP15_05700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP15_05705	COG5504	Zn-dependent protease
UP15_05710	COG0444	Belongs to the ABC transporter superfamily
UP15_05715	COG4608	Belongs to the ABC transporter superfamily
UP15_05725	COG0601	transmembrane transport
UP15_05730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP15_05740	COG0180	Tryptophanyl-tRNA synthetase
UP15_05750	COG4166	transmembrane transport
UP15_05755	COG0601	transmembrane transport
UP15_05760	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP15_05765	COG0444	Belongs to the ABC transporter superfamily
UP15_05770	COG4608	Belongs to the ABC transporter superfamily
UP15_05780	COG0456	acetyltransferase
UP15_05785	COG1393	Belongs to the ArsC family
UP15_05790	COG0861	Integral membrane protein TerC family
UP15_05795	COG4862	establishment of competence for transformation
UP15_05800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP15_05810	COG1164	Oligoendopeptidase f
UP15_05825	COG2346	COG2346, Truncated hemoglobins
UP15_05830	COG0741	lytic transglycosylase activity
UP15_05835	COG4116	CYTH
UP15_05845	COG2357	RelA SpoT domain protein
UP15_05850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP15_05855	COG0564	pseudouridine synthase activity
UP15_05860	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UP15_05865	COG0475	glutathione-regulated potassium exporter activity
UP15_05865	COG0569	domain protein
UP15_05870	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP15_05875	COG0352	thiamine-phosphate diphosphorylase activity
UP15_05885	COG2104	thiamine diphosphate biosynthetic process
UP15_05890	COG2022	thiamine diphosphate biosynthetic process
UP15_05895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP15_05900	COG0351	phosphomethylpyrimidine kinase
UP15_05905	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UP15_05960	COG0210	DNA helicase
UP15_05970	COG2801	Transposase and inactivated derivatives
UP15_05980	COG2153	protein acetylation
UP15_05985	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UP15_05990	COG2382	esterase
UP15_05995	COG0626	cystathionine gamma-synthase activity
UP15_06000	COG0626	cystathionine gamma-synthase activity
UP15_06020	COG1280	lysine exporter protein (LysE YggA)
UP15_06030	COG2153	protein acetylation
UP15_06035	COG2364	Membrane
UP15_06075	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
UP15_06080	COG0583	DNA-binding transcription factor activity
UP15_06100	COG0583	DNA-binding transcription factor activity
UP15_06105	COG2807	transmembrane transport
UP15_06130	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UP15_06150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP15_06155	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP15_06175	COG4195	phage-related replication protein
UP15_06180	COG2856	Zn peptidase
UP15_06185	COG3409	Peptidoglycan-binding domain 1 protein
UP15_06185	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP15_06200	COG0306	phosphate transporter
UP15_06205	COG1392	Phosphate transport regulator
UP15_06215	COG0405	Gamma-glutamyltransferase
UP15_06220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UP15_06230	COG4208	sulfate ABC transporter
UP15_06245	COG3775	system Galactitol-specific IIC component
UP15_06260	COG1063	alcohol dehydrogenase
UP15_06265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP15_06270	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP15_06270	COG0022	dehydrogenase e1 component
UP15_06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP15_06280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP15_06285	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_06290	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_06295	COG2390	Transcriptional regulator
UP15_06305	COG0531	amino acid
UP15_06310	COG0346	lactoylglutathione lyase activity
UP15_06315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP15_06320	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP15_06325	COG2362	D-Aminopeptidase
UP15_06330	COG0601	transmembrane transport
UP15_06335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP15_06340	COG0444	Belongs to the ABC transporter superfamily
UP15_06345	COG4166	transmembrane transport
UP15_06350	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP15_06355	COG4948	Mandelate Racemase Muconate Lactonizing
UP15_06360	COG0791	NLP P60 protein
UP15_06365	COG4608	Belongs to the ABC transporter superfamily
UP15_06370	COG1834	amidinotransferase
UP15_06375	COG1607	acyl-coa hydrolase
UP15_06380	COG1695	Transcriptional regulator
UP15_06395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP15_06405	COG2076	Multidrug Resistance protein
UP15_06410	COG2076	Multidrug Resistance protein
UP15_06420	COG0788	formyltetrahydrofolate deformylase activity
UP15_06425	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP15_06430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP15_06435	COG0457	Tetratricopeptide repeat
UP15_06445	COG1764	response to oxidative stress
UP15_06450	COG1846	Transcriptional regulator
UP15_06455	COG1764	response to oxidative stress
UP15_06460	COG0590	tRNA wobble adenosine to inosine editing
UP15_06465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UP15_06470	COG1404	Belongs to the peptidase S8 family
UP15_06485	COG0745	RESPONSE REGULATOR receiver
UP15_06490	COG3850	Histidine kinase
UP15_06490	COG5002	protein histidine kinase activity
UP15_06495	COG3212	peptidase
UP15_06500	COG3212	peptidase
UP15_06515	COG0583	DNA-binding transcription factor activity
UP15_06525	COG0789	Transcriptional regulator
UP15_06535	COG1846	Transcriptional regulator
UP15_06540	COG3300	MHYT domain
UP15_06540	COG5001	Diguanylate cyclase
UP15_06545	COG0586	Pfam SNARE associated Golgi protein
UP15_06550	COG0861	Integral membrane protein TerC family
UP15_06555	COG1191	sigma factor activity
UP15_06575	COG0501	Belongs to the peptidase M48B family
UP15_06580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP15_06585	COG2323	membrane
UP15_06595	COG3594	Acyltransferase
UP15_06600	COG5002	protein histidine kinase activity
UP15_06605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UP15_06610	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UP15_06615	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
UP15_06620	COG0436	Aminotransferase
UP15_06625	COG1850	ribulose-bisphosphate carboxylase activity
UP15_06630	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
UP15_06635	COG0235	Class ii aldolase
UP15_06640	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
UP15_06650	COG3852	Histidine kinase
UP15_06655	COG1846	Transcriptional regulator
UP15_06660	COG1360	Flagellar Motor Protein
UP15_06665	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UP15_06670	COG0542	response to heat
UP15_06675	COG3949	Membrane
UP15_06680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UP15_06685	COG0720	synthase
UP15_06690	COG0602	queuosine metabolic process
UP15_06695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UP15_06705	COG4873	Protein conserved in bacteria
UP15_06715	COG3773	Cell wall hydrolase
UP15_06720	COG2244	polysaccharide biosynthetic process
UP15_06725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_06730	COG2217	Heavy metal translocating P-type atpase
UP15_06735	COG0006	proline dipeptidase activity
UP15_06740	COG1609	Transcriptional regulator
UP15_06745	COG3711	transcriptional antiterminator
UP15_06750	COG2190	(PTS) system
UP15_06750	COG1263	PTS System
UP15_06750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_06755	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_06760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UP15_06770	COG1533	DNA photolyase activity
UP15_06775	COG0840	transmembrane signaling receptor activity
UP15_06785	COG2084	Dehydrogenase
UP15_06790	COG2340	Cysteine-rich secretory protein family
UP15_06795	COG0768	penicillin binding
UP15_06800	COG4191	Histidine kinase
UP15_06805	COG0436	Aminotransferase
UP15_06810	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP15_06815	COG1714	RDD family
UP15_06825	COG0784	Response regulator, receiver
UP15_06825	COG0835	chemotaxis
UP15_06835	COG0582	viral genome integration into host DNA
UP15_06845	COG1396	sequence-specific DNA binding
UP15_06860	COG3645	SOS response
UP15_06860	COG3646	Phage regulatory protein
UP15_06895	COG0305	Participates in initiation and elongation during chromosome replication
UP15_07005	COG3953	SLT domain
UP15_07005	COG5280	Phage tail tape measure protein TP901
UP15_07050	COG3409	Peptidoglycan-binding domain 1 protein
UP15_07050	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP15_07060	COG0457	Tetratricopeptide repeat
UP15_07080	COG2814	Major facilitator Superfamily
UP15_07085	COG1376	ErfK ybiS ycfS ynhG family protein
UP15_07090	COG1408	metallophosphoesterase
UP15_07095	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_07100	COG2200	EAL domain
UP15_07105	COG3546	catalase activity
UP15_07110	COG4703	Protein of unknown function (DUF1797)
UP15_07115	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
UP15_07125	COG0517	IMP dehydrogenase activity
UP15_07130	COG0583	DNA-binding transcription factor activity
UP15_07140	COG0716	FMN binding
UP15_07150	COG0716	FMN binding
UP15_07155	COG2171	N-acyltransferase activity
UP15_07160	COG1473	amidohydrolase
UP15_07170	COG0668	transmembrane transport
UP15_07175	COG0450	alkyl hydroperoxide reductase
UP15_07180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_07195	COG0746	molybdenum cofactor guanylyltransferase activity
UP15_07200	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP15_07205	COG0303	'Molybdopterin
UP15_07210	COG1763	Mo-molybdopterin cofactor biosynthetic process
UP15_07215	COG0314	molybdopterin synthase activity
UP15_07220	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
UP15_07235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UP15_07240	COG1136	(ABC) transporter
UP15_07245	COG0577	efflux transmembrane transporter activity
UP15_07250	COG1349	DNA-binding transcription factor activity
UP15_07255	COG1105	Belongs to the carbohydrate kinase PfkB family
UP15_07260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_07260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_07260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_07265	COG0681	Belongs to the peptidase S26 family
UP15_07275	COG0488	(ABC) transporter
UP15_07280	COG2309	aminopeptidase activity
UP15_07285	COG1077	Cell shape determining protein MreB Mrl
UP15_07290	COG2002	toxin-antitoxin pair type II binding
UP15_07295	COG3852	Histidine kinase
UP15_07300	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
UP15_07300	COG2105	PFAM AIG2 family protein
UP15_07305	COG0569	domain protein
UP15_07310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UP15_07315	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP15_07325	COG0561	phosphatase activity
UP15_07330	COG0242	peptide deformylase activity
UP15_07345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP15_07350	COG0022	dehydrogenase e1 component
UP15_07355	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP15_07360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP15_07365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_07370	COG1982	Orn Lys Arg decarboxylase major
UP15_07375	COG4476	Belongs to the UPF0223 family
UP15_07380	COG4493	Belongs to the UPF0637 family
UP15_07390	COG0483	inositol monophosphate 1-phosphatase activity
UP15_07405	COG1595	DNA-templated transcription, initiation
UP15_07435	COG4896	Protein conserved in bacteria
UP15_07450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UP15_07455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UP15_07460	COG2066	Belongs to the glutaminase family
UP15_07465	COG4838	Belongs to the UPF0358 family
UP15_07470	COG0772	Belongs to the SEDS family
UP15_07475	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UP15_07485	COG1612	heme a metabolic process
UP15_07490	COG0109	protoheme IX farnesyltransferase activity
UP15_07495	COG2010	Cytochrome c
UP15_07495	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UP15_07500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UP15_07505	COG1845	cytochrome c oxidase, subunit III
UP15_07510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UP15_07515	COG3336	cytochrome c oxidase
UP15_07525	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
UP15_07530	COG2340	Cysteine-rich secretory protein family
UP15_07550	COG3679	Belongs to the UPF0342 family
UP15_07555	COG4471	UPF0298 protein
UP15_07560	COG0742	ribosomal rna small subunit methyltransferase
UP15_07565	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UP15_07570	COG3314	Sporulation integral membrane protein YlbJ
UP15_07575	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP15_07580	COG3480	Lon protease (S16) C-terminal proteolytic domain
UP15_07590	COG1399	metal-binding, possibly nucleic acid-binding protein
UP15_07595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UP15_07605	COG0454	-acetyltransferase
UP15_07610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UP15_07615	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
UP15_07620	COG2001	Belongs to the MraZ family
UP15_07625	COG0275	rRNA processing
UP15_07630	COG4839	cell division protein FtsL
UP15_07640	COG0768	penicillin binding
UP15_07645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UP15_07650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP15_07655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UP15_07660	COG0772	Belongs to the SEDS family
UP15_07665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UP15_07670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UP15_07675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UP15_07680	COG3879	Bacterial protein of unknown function (DUF881)
UP15_07685	COG3879	Bacterial protein of unknown function (DUF881)
UP15_07690	COG3856	small basic protein
UP15_07695	COG0849	cell division
UP15_07700	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UP15_07705	COG4412	M6 family metalloprotease domain protein
UP15_07705	COG1404	Belongs to the peptidase S8 family
UP15_07715	COG1191	sigma factor activity
UP15_07720	COG1191	sigma factor activity
UP15_07725	COG2390	Transcriptional regulator
UP15_07740	COG3730	PTS system glucitol sorbitol-specific
UP15_07745	COG3732	PTS system glucitol sorbitol-specific
UP15_07755	COG1119	ATPase activity
UP15_07760	COG1873	PFAM PRC-barrel domain
UP15_07770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UP15_07775	COG1799	cell septum assembly
UP15_07780	COG0762	integral membrane protein
UP15_07785	COG2302	S4 RNA-binding domain
UP15_07790	COG3599	regulation of cell shape
UP15_07795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UP15_07800	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP15_07805	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UP15_07810	COG0564	pseudouridine synthase activity
UP15_07815	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UP15_07820	COG2233	PERMEase
UP15_07825	COG0540	Belongs to the ATCase OTCase family
UP15_07830	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UP15_07835	COG0505	Belongs to the CarA family
UP15_07840	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UP15_07845	COG0543	2 iron, 2 sulfur cluster binding
UP15_07850	COG0167	dihydroorotate dehydrogenase activity
UP15_07855	COG0284	orotidine-5'-phosphate decarboxylase activity
UP15_07860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UP15_07865	COG0175	sulfate reduction
UP15_07870	COG0306	phosphate transporter
UP15_07875	COG2046	Belongs to the sulfate adenylyltransferase family
UP15_07880	COG0529	Catalyzes the synthesis of activated sulfate
UP15_07885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UP15_07890	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
UP15_07895	COG1648	precorrin-2 dehydrogenase activity
UP15_07905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UP15_07910	COG1561	YicC-like family, N-terminal region
UP15_07915	COG2052	Domain of unknown function (DUF370)
UP15_07920	COG0194	GDP metabolic process
UP15_07925	COG1758	RNA polymerase activity
UP15_07930	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP15_07935	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UP15_07940	COG0242	peptide deformylase activity
UP15_07945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UP15_07950	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP15_07950	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UP15_07955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UP15_07960	COG0631	protein serine/threonine phosphatase activity
UP15_07965	COG0515	serine threonine protein kinase
UP15_07965	COG2815	serine threonine protein kinase
UP15_07970	COG1162	GTPase activity
UP15_07975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UP15_07980	COG1564	THIamine pyrophosphokinase
UP15_07990	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UP15_07995	COG1302	Protein conserved in bacteria
UP15_08000	COG1461	Dihydroxyacetone kinase
UP15_08005	COG1760	l-serine dehydratase
UP15_08010	COG1760	l-serine dehydratase
UP15_08015	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UP15_08020	COG1349	DNA-binding transcription factor activity
UP15_08025	COG0416	fatty acid biosynthetic process
UP15_08030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UP15_08035	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_08040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP15_08050	COG1196	nuclear chromosome segregation
UP15_08055	COG0552	protein localization to endoplasmic reticulum
UP15_08060	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
UP15_08065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UP15_08070	COG0228	four-way junction DNA binding
UP15_08075	COG1837	Belongs to the UPF0109 family
UP15_08085	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UP15_08090	COG0336	Belongs to the RNA methyltransferase TrmD family
UP15_08095	COG0335	large ribosomal subunit rRNA binding
UP15_08100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP15_08105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP15_08115	COG2257	FlhB HrpN YscU SpaS Family
UP15_08120	COG0045	succinate-CoA ligase (ADP-forming) activity
UP15_08125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UP15_08130	COG0758	DNA mediated transformation
UP15_08135	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP15_08140	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
UP15_08145	COG4974	Belongs to the 'phage' integrase family
UP15_08150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
UP15_08155	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UP15_08160	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP15_08165	COG1815	bacterial-type flagellum-dependent cell motility
UP15_08170	COG1558	bacterial-type flagellum-dependent cell motility
UP15_08175	COG1677	Flagellar hook-basal body complex protein FliE
UP15_08180	COG1766	The M ring may be actively involved in energy transduction
UP15_08185	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP15_08190	COG1317	bacterial-type flagellum organization
UP15_08195	COG1157	protein secretion by the type III secretion system
UP15_08200	COG2882	bacterial-type flagellum organization
UP15_08205	COG3334	PFAM MgtE intracellular
UP15_08210	COG3144	bacterial-type flagellum assembly
UP15_08215	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UP15_08220	COG4786	Flagellar basal body rod
UP15_08225	COG1582	Flagellar protein (FlbD)
UP15_08230	COG1580	Controls the rotational direction of flagella during chemotaxis
UP15_08235	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP15_08240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP15_08240	COG1776	CheC inhibitor of MCP methylation
UP15_08245	COG2201	protein-glutamate methylesterase activity
UP15_08250	COG3190	flagellar
UP15_08255	COG1338	Plays a role in the flagellum-specific transport system
UP15_08260	COG1987	bacterial-type flagellum assembly
UP15_08265	COG1684	flagellar biosynthetic protein fliR
UP15_08270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP15_08275	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP15_08280	COG1419	protein localization to endoplasmic reticulum
UP15_08285	COG0455	bacterial-type flagellum organization
UP15_08290	COG2201	protein-glutamate methylesterase activity
UP15_08295	COG0643	Histidine kinase
UP15_08295	COG2198	Histidine kinase
UP15_08300	COG0835	chemotaxis
UP15_08305	COG1776	CheC inhibitor of MCP methylation
UP15_08315	COG1191	sigma factor activity
UP15_08330	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UP15_08335	COG0528	UMP kinase activity
UP15_08340	COG0233	cytoplasmic translational termination
UP15_08345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UP15_08350	COG4589	Belongs to the CDS family
UP15_08355	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UP15_08360	COG0750	zinc metalloprotease
UP15_08365	COG0442	prolyl-tRNA aminoacylation
UP15_08370	COG2176	DNA-directed DNA polymerase activity
UP15_08395	COG0779	Required for maturation of 30S ribosomal subunits
UP15_08400	COG0195	Participates in both transcription termination and antitermination
UP15_08405	COG2740	Nucleic-acid-binding protein implicated in transcription termination
UP15_08410	COG1358	cellular component organization or biogenesis
UP15_08415	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UP15_08420	COG1550	Protein conserved in bacteria
UP15_08425	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UP15_08430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UP15_08435	COG0196	riboflavin kinase activity
UP15_08440	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UP15_08445	COG1185	polyribonucleotide nucleotidyltransferase activity
UP15_08450	COG0726	polysaccharide deacetylase
UP15_08455	COG0612	Peptidase, M16
UP15_08465	COG1873	PFAM PRC-barrel domain
UP15_08470	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP15_08475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP15_08480	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UP15_08485	COG0527	aspartate kinase activity
UP15_08495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP15_08500	COG0740	serine-type endopeptidase activity
UP15_08510	COG1674	ftsk spoiiie
UP15_08510	COG4980	gas vesicle protein
UP15_08515	COG2188	Transcriptional regulator
UP15_08520	COG2814	Major facilitator Superfamily
UP15_08525	COG2409	Drug exporters of the RND superfamily
UP15_08525	COG1033	growth of symbiont in host cell
UP15_08530	COG0612	Peptidase, M16
UP15_08535	COG0612	Peptidase, M16
UP15_08545	COG1033	growth of symbiont in host cell
UP15_08545	COG2409	Drug exporters of the RND superfamily
UP15_08550	COG0300	oxidoreductase activity
UP15_08565	COG1426	Protein conserved in bacteria
UP15_08570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UP15_08575	COG1546	Belongs to the CinA family
UP15_08575	COG1058	Belongs to the CinA family
UP15_08580	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UP15_08585	COG1418	mRNA catabolic process
UP15_08590	COG1692	metallophosphoesterase
UP15_08595	COG2359	stage V sporulation protein S
UP15_08600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP15_08605	COG1063	alcohol dehydrogenase
UP15_08610	COG0156	8-amino-7-oxononanoate synthase activity
UP15_08620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP15_08625	COG4550	Control of competence regulator ComK, YlbF/YmcA
UP15_08635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
UP15_08640	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UP15_08665	COG1329	Transcriptional regulator
UP15_08675	COG4195	phage-related replication protein
UP15_08680	COG0457	Tetratricopeptide repeat
UP15_08685	COG1404	Belongs to the peptidase S8 family
UP15_08690	COG4195	phage-related replication protein
UP15_08695	COG1764	response to oxidative stress
UP15_08700	COG2076	Multidrug Resistance protein
UP15_08725	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UP15_08730	COG1923	regulation of RNA biosynthetic process
UP15_08745	COG1780	Probably involved in ribonucleotide reductase function
UP15_08750	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP15_08755	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP15_08760	COG4112	unkown
UP15_08770	COG0464	growth
UP15_08775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UP15_08780	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
UP15_08785	COG0789	Transcriptional regulator
UP15_08790	COG0174	glutamine synthetase
UP15_08810	COG0457	Tetratricopeptide repeat
UP15_08815	COG5444	nuclease activity
UP15_08830	COG5646	InterPro IPR014922
UP15_08850	COG0457	Tetratricopeptide repeat
UP15_08860	COG3619	membrane
UP15_08865	COG3285	dna ligase
UP15_08865	COG1793	dna ligase
UP15_08870	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
UP15_08875	COG4876	unkown
UP15_08885	COG1959	2 iron, 2 sulfur cluster binding
UP15_08890	COG0702	epimerase
UP15_08900	COG0247	lactate metabolic process
UP15_08905	COG1139	Iron-sulfur cluster binding protein
UP15_08910	COG1556	Lactate utilization protein
UP15_08930	COG2323	membrane
UP15_08935	COG1309	transcriptional regulator
UP15_08940	COG2124	cytochrome p450
UP15_08940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UP15_08945	COG3591	Belongs to the peptidase S1B family
UP15_08950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
UP15_08955	COG3209	COG3209 Rhs family protein
UP15_08960	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_08975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UP15_08980	COG1388	LysM domain
UP15_08985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UP15_08990	COG4224	UPF0291 protein
UP15_08995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UP15_09005	COG3763	UPF0154 protein
UP15_09015	COG0785	Cytochrome C biogenesis protein
UP15_09020	COG4846	Membrane protein involved in cytochrome C biogenesis
UP15_09030	COG0071	Belongs to the small heat shock protein (HSP20) family
UP15_09045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UP15_09050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_09065	COG0824	Thioesterase
UP15_09075	COG4841	protein insertion into membrane
UP15_09080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UP15_09085	COG1832	CoA-binding protein
UP15_09090	COG0187	DNA topoisomerase II activity
UP15_09095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP15_09105	COG0738	Major facilitator superfamily
UP15_09110	COG0473	3-isopropylmalate dehydrogenase activity
UP15_09115	COG0110	maltose O-acetyltransferase activity
UP15_09120	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP15_09125	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP15_09130	COG0640	Transcriptional regulator
UP15_09145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP15_09150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP15_09160	COG1309	transcriptional regulator
UP15_09165	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP15_09170	COG1733	regulation of RNA biosynthetic process
UP15_09175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP15_09180	COG0251	oxidation-reduction process
UP15_09215	COG0657	acetylesterase activity
UP15_09220	COG0789	Transcriptional regulator
UP15_09230	COG2205	protein histidine kinase activity
UP15_09235	COG0745	RESPONSE REGULATOR receiver
UP15_09245	COG3507	Belongs to the glycosyl hydrolase 43 family
UP15_09250	COG1012	belongs to the aldehyde dehydrogenase family
UP15_09255	COG1486	melibiose metabolic process
UP15_09280	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UP15_09295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_09310	COG2369	cell adhesion
UP15_09325	COG5444	nuclease activity
UP15_09330	COG1846	Transcriptional regulator
UP15_09335	COG2814	Major facilitator Superfamily
UP15_09345	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_09345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_09345	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_09350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_09350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP15_09350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_09355	COG1105	Belongs to the carbohydrate kinase PfkB family
UP15_09365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP15_09390	COG3591	Belongs to the peptidase S1B family
UP15_09400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UP15_09405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP15_09415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP15_09420	COG1024	Enoyl-CoA hydratase
UP15_09425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP15_09430	COG0511	ligase activity, forming carbon-carbon bonds
UP15_09435	COG0439	Biotin carboxylase
UP15_09440	COG0318	PFAM AMP-dependent synthetase and ligase
UP15_09445	COG1960	acyl-CoA dehydrogenase activity
UP15_09450	COG1649	PFAM Uncharacterised BCR, COG1649
UP15_09460	COG1349	DNA-binding transcription factor activity
UP15_09465	COG1942	4-Oxalocrotonate Tautomerase
UP15_09475	COG3835	regulator
UP15_09480	COG0277	FAD linked oxidase domain protein
UP15_09485	COG0247	lactate metabolic process
UP15_09505	COG0166	Belongs to the GPI family
UP15_09510	COG2246	polysaccharide biosynthetic process
UP15_09515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP15_09520	COG0586	Pfam SNARE associated Golgi protein
UP15_09525	COG1587	Uroporphyrinogen-III synthase
UP15_09540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP15_09545	COG0534	Mate efflux family protein
UP15_09550	COG2027	D-alanyl-D-alanine carboxypeptidase
UP15_09555	COG4677	pectinesterase activity
UP15_09560	COG2323	membrane
UP15_09565	COG2146	nitrite reductase [NAD(P)H] activity
UP15_09570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP15_09575	COG0243	molybdopterin cofactor binding
UP15_09580	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP15_09585	COG2223	nitrite transmembrane transporter activity
UP15_09590	COG0493	'glutamate synthase
UP15_09595	COG0069	glutamate synthase activity
UP15_09595	COG0070	glutamate synthase
UP15_09595	COG0067	glutamate synthase
UP15_09600	COG0583	DNA-binding transcription factor activity
UP15_09610	COG1132	(ABC) transporter
UP15_09615	COG0789	Transcriptional regulator
UP15_09615	COG4978	Transcriptional regulator
UP15_09620	COG0454	-acetyltransferase
UP15_09625	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP15_09630	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP15_09635	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP15_09645	COG0243	molybdopterin cofactor binding
UP15_09655	COG1070	Carbohydrate kinase
UP15_09660	COG2115	Belongs to the xylose isomerase family
UP15_09665	COG1940	carbohydrate kinase activity
UP15_09675	COG2211	Major facilitator Superfamily
UP15_09680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP15_09685	COG1994	Peptidase M50
UP15_09705	COG1309	transcriptional regulator
UP15_09710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP15_09715	COG3708	Transcriptional regulator
UP15_09720	COG2378	regulation of single-species biofilm formation
UP15_09730	COG0640	Transcriptional regulator
UP15_09735	COG0531	amino acid
UP15_09740	COG0741	lytic transglycosylase activity
UP15_09745	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UP15_09750	COG2079	MmgE PrpD family protein
UP15_09755	COG0372	Belongs to the citrate synthase family
UP15_09760	COG2322	membrane
UP15_09770	COG3584	3D domain protein
UP15_09770	COG1388	LysM domain
UP15_09775	COG0514	ATP-dependent DNA helicase (RecQ)
UP15_09780	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP15_09800	COG1012	belongs to the aldehyde dehydrogenase family
UP15_09810	COG1657	PFAM Prenyltransferase squalene oxidase
UP15_09815	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UP15_09820	COG0385	Bile acid
UP15_09825	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP15_09830	COG0567	Dehydrogenase, E1 component
UP15_09835	COG4548	von Willebrand factor, type A
UP15_09840	COG0714	Associated with various cellular activities
UP15_09845	COG2032	superoxide dismutase activity
UP15_09850	COG0791	NLP P60 protein
UP15_09850	COG1388	LysM domain
UP15_09855	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UP15_09860	COG0534	Mate efflux family protein
UP15_09865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP15_09870	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP15_09880	COG2962	Rard protein
UP15_09895	COG1733	regulation of RNA biosynthetic process
UP15_09900	COG0778	Nitroreductase
UP15_09910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP15_09915	COG0793	Belongs to the peptidase S41A family
UP15_09915	COG3409	Peptidoglycan-binding domain 1 protein
UP15_09920	COG2226	methyltransferase
UP15_09930	COG1876	peptidase activity
UP15_09935	COG0813	purine-nucleoside phosphorylase activity
UP15_09945	COG0671	phosphoesterase, PA-phosphatase related
UP15_09955	COG4479	Belongs to the UPF0346 family
UP15_09965	COG1509	lysine 2,3-aminomutase activity
UP15_09970	COG3829	transcription factor binding
UP15_09975	COG0463	Glycosyl transferase, family 2
UP15_09990	COG4641	Protein conserved in bacteria
UP15_10000	COG1086	Polysaccharide biosynthesis protein
UP15_10005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP15_10010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP15_10015	COG1846	Transcriptional regulator
UP15_10035	COG4698	Protein conserved in bacteria
UP15_10040	COG2755	lipolytic protein G-D-S-L family
UP15_10045	COG1999	signal sequence binding
UP15_10060	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UP15_10065	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
UP15_10070	COG1272	protein, Hemolysin III
UP15_10075	COG0204	Acyl-transferase
UP15_10080	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP15_10085	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
UP15_10090	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP15_10100	COG2521	methyltransferase
UP15_10100	COG2136	Putative SAM-dependent methyltransferase
UP15_10110	COG0129	dihydroxy-acid dehydratase activity
UP15_10120	COG1418	mRNA catabolic process
UP15_10125	COG0386	Belongs to the glutathione peroxidase family
UP15_10130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
UP15_10135	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
UP15_10140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UP15_10155	COG1278	Cold shock
UP15_10170	COG0328	RNA-DNA hybrid ribonuclease activity
UP15_10175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
UP15_10180	COG0328	RNA-DNA hybrid ribonuclease activity
UP15_10190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP15_10200	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP15_10205	COG1755	Isoprenylcysteine carboxyl methyltransferase
UP15_10210	COG3424	synthase
UP15_10220	COG0456	acetyltransferase
UP15_10220	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP15_10225	COG0726	polysaccharide deacetylase
UP15_10230	COG2233	PERMEase
UP15_10235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP15_10240	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
UP15_10245	COG1199	ATP-dependent helicase activity
UP15_10255	COG0116	Belongs to the methyltransferase superfamily
UP15_10260	COG3599	regulation of cell shape
UP15_10265	COG4474	Belongs to the UPF0398 family
UP15_10270	COG3359	exonuclease
UP15_10275	COG1205	dead DEAH box helicase
UP15_10275	COG1111	helicase
UP15_10280	COG1902	pentaerythritol trinitrate reductase activity
UP15_10285	COG2190	(PTS) system
UP15_10290	COG0071	Belongs to the small heat shock protein (HSP20) family
UP15_10320	COG3331	DNA recombination
UP15_10325	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP15_10325	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP15_10335	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UP15_10340	COG3935	DnaD domain protein
UP15_10345	COG0017	Asparaginyl-tRNA synthetase
UP15_10350	COG5353	protein conserved in bacteria
UP15_10355	COG1199	ATP-dependent helicase activity
UP15_10355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UP15_10360	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UP15_10365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UP15_10370	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UP15_10380	COG0617	tRNA 3'-terminal CCA addition
UP15_10385	COG0438	transferase activity, transferring glycosyl groups
UP15_10390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP15_10395	COG1803	Methylglyoxal synthase
UP15_10400	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UP15_10405	COG1694	Mazg nucleotide pyrophosphohydrolase
UP15_10410	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP15_10420	COG4347	Protein of unknown function (DUF1405)
UP15_10425	COG2010	Cytochrome c
UP15_10425	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UP15_10430	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UP15_10435	COG0723	plastoquinol--plastocyanin reductase activity
UP15_10445	COG5582	Belongs to the UPF0302 family
UP15_10450	COG0457	Tetratricopeptide repeat
UP15_10455	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UP15_10460	COG0287	Prephenate dehydrogenase
UP15_10465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP15_10470	COG0159	tryptophan synthase activity
UP15_10475	COG0133	tryptophan synthase activity
UP15_10480	COG0135	phosphoribosylanthranilate isomerase activity
UP15_10485	COG0134	indole-3-glycerol-phosphate synthase activity
UP15_10490	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UP15_10500	COG4401	Chorismate mutase type I
UP15_10505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UP15_10510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UP15_10515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UP15_10520	COG0105	UTP biosynthetic process
UP15_10525	COG0142	geranyltranstransferase activity
UP15_10530	COG2226	methyltransferase
UP15_10535	COG0142	geranyltranstransferase activity
UP15_10545	COG0302	gtp cyclohydrolase
UP15_10550	COG0776	regulation of translation
UP15_10555	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP15_10570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UP15_10575	COG1160	GTP binding
UP15_10595	COG1304	FMN binding
UP15_10600	COG0539	negative regulation of cytoplasmic translation
UP15_10605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UP15_10615	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
UP15_10620	COG2959	enzyme of heme biosynthesis
UP15_10625	COG3409	Peptidoglycan-binding domain 1 protein
UP15_10625	COG3773	Cell wall hydrolase
UP15_10630	COG2339	peptidase activity
UP15_10635	COG0492	ferredoxin-NADP+ reductase activity
UP15_10640	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP15_10645	COG4862	establishment of competence for transformation
UP15_10650	COG1408	metallophosphoesterase
UP15_10660	COG1388	LysM domain
UP15_10665	COG1266	CAAX protease self-immunity
UP15_10670	COG0514	ATP-dependent DNA helicase (RecQ)
UP15_10675	COG4955	Helix-turn-helix domain
UP15_10680	COG1141	Ferredoxin
UP15_10685	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
UP15_10690	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UP15_10705	COG1595	DNA-templated transcription, initiation
UP15_10710	COG5002	protein histidine kinase activity
UP15_10715	COG0745	RESPONSE REGULATOR receiver
UP15_10720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP15_10725	COG1333	cytochrome c biogenesis protein
UP15_10730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_10735	COG1187	pseudouridine synthase activity
UP15_10740	COG0700	Nucleoside recognition
UP15_10745	COG2715	membrane protein required for spore maturation
UP15_10750	COG1686	Belongs to the peptidase S11 family
UP15_10760	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UP15_10765	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
UP15_10770	COG1547	Domain of unknown function (DUF309)
UP15_10775	COG0456	acetyltransferase
UP15_10780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UP15_10790	COG0307	riboflavin synthase, alpha
UP15_10810	COG2814	Major facilitator Superfamily
UP15_10815	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UP15_10820	COG4086	secreted protein
UP15_10825	COG0019	diaminopimelate decarboxylase activity
UP15_10830	COG0697	spore germination
UP15_10845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP15_10865	COG1191	sigma factor activity
UP15_10870	COG2172	sigma factor antagonist activity
UP15_10880	COG1686	Belongs to the peptidase S11 family
UP15_10885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
UP15_10890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
UP15_10895	COG4974	Belongs to the 'phage' integrase family
UP15_10905	COG0735	belongs to the Fur family
UP15_10910	COG1300	Membrane
UP15_10915	COG1404	Belongs to the peptidase S8 family
UP15_10925	COG2153	protein acetylation
UP15_10930	COG1379	DNA repair
UP15_10935	COG0494	nUDIX hydrolase
UP15_10940	COG0667	Aldo Keto reductase
UP15_10950	COG1073	alpha beta
UP15_10955	COG0457	Tetratricopeptide repeat
UP15_10965	COG4918	Iron-sulphur cluster biosynthesis
UP15_10970	COG4305	rare lipoprotein A
UP15_10975	COG0456	acetyltransferase
UP15_10975	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP15_10980	COG0456	acetyltransferase
UP15_10990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP15_11000	COG2211	Major facilitator Superfamily
UP15_11005	COG1072	(Pantothenic acid kinase))
UP15_11010	COG0446	pyridine nucleotide-disulphide oxidoreductase
UP15_11020	COG0300	oxidoreductase activity
UP15_11025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP15_11030	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP15_11045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP15_11050	COG4187	Peptidase family M20/M25/M40
UP15_11055	COG1902	pentaerythritol trinitrate reductase activity
UP15_11060	COG0596	Alpha beta hydrolase
UP15_11065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP15_11075	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UP15_11080	COG2188	Transcriptional regulator
UP15_11085	COG2723	6-phospho-beta-galactosidase activity
UP15_11090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP15_11095	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP15_11100	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP15_11110	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_11120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UP15_11125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP15_11135	COG0706	membrane insertase activity
UP15_11140	COG0835	chemotaxis
UP15_11145	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP15_11150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP15_11155	COG0346	lactoylglutathione lyase activity
UP15_11160	COG1376	ErfK ybiS ycfS ynhG family protein
UP15_11165	COG4129	membrane
UP15_11170	COG1126	abc transporter atp-binding protein
UP15_11175	COG0765	amino acid transport
UP15_11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_11190	COG1597	lipid kinase activity
UP15_11200	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP15_11205	COG0022	dehydrogenase e1 component
UP15_11210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP15_11215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP15_11220	COG3426	butyrate kinase activity
UP15_11225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP15_11230	COG0280	phosphate acetyltransferase
UP15_11235	COG3290	protein histidine kinase activity
UP15_11235	COG3829	transcription factor binding
UP15_11245	COG0584	glycerophosphoryl diester phosphodiesterase
UP15_11250	COG0457	Tetratricopeptide repeat
UP15_11255	COG0745	RESPONSE REGULATOR receiver
UP15_11260	COG0750	zinc metalloprotease
UP15_11265	COG0497	DNA recombination
UP15_11270	COG1438	arginine binding
UP15_11275	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
UP15_11280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UP15_11285	COG0142	geranyltranstransferase activity
UP15_11290	COG1722	exodeoxyribonuclease VII activity
UP15_11295	COG1570	exodeoxyribonuclease VII activity
UP15_11300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UP15_11305	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP15_11310	COG1302	Protein conserved in bacteria
UP15_11315	COG0439	Biotin carboxylase
UP15_11320	COG0511	ligase activity, forming carbon-carbon bonds
UP15_11360	COG3854	ATPases associated with a variety of cellular activities
UP15_11370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UP15_11375	COG0006	proline dipeptidase activity
UP15_11380	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UP15_11390	COG3872	metal-dependent enzyme
UP15_11400	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP15_11405	COG1321	iron dependent repressor
UP15_11410	COG0095	Lipoate-protein ligase
UP15_11415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP15_11420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP15_11425	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP15_11430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
UP15_11435	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP15_11455	COG0681	Belongs to the peptidase S26 family
UP15_11490	COG4970	Tfp pilus assembly protein FimT
UP15_11495	COG4537	Required for transformation and DNA binding
UP15_11500	COG1459	type II secretion system
UP15_11505	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UP15_11510	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_11520	COG1393	Belongs to the ArsC family
UP15_11530	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP15_11540	COG0011	TIGRFAM Protein of
UP15_11545	COG2814	Major facilitator Superfamily
UP15_11550	COG2866	Carboxypeptidase
UP15_11555	COG1368	sulfuric ester hydrolase activity
UP15_11560	COG1940	carbohydrate kinase activity
UP15_11565	COG4483	Protein conserved in bacteria
UP15_11570	COG0705	Rhomboid family
UP15_11570	COG0457	Tetratricopeptide repeat
UP15_11580	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UP15_11585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UP15_11600	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UP15_11605	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UP15_11610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UP15_11615	COG0581	inorganic phosphate transmembrane transporter activity
UP15_11620	COG0573	inorganic phosphate transmembrane transporter activity
UP15_11625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UP15_11635	COG0477	Major facilitator Superfamily
UP15_11640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UP15_11645	COG2839	Protein conserved in bacteria
UP15_11650	COG5521	maltodextrose utilization protein MalA
UP15_11655	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP15_11660	COG1388	LysM domain
UP15_11665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UP15_11670	COG4709	membrane
UP15_11675	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
UP15_11680	COG1940	carbohydrate kinase activity
UP15_11685	COG0735	belongs to the Fur family
UP15_11690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UP15_11695	COG1121	(ABC) transporter
UP15_11700	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP15_11715	COG0513	Belongs to the DEAD box helicase family
UP15_11725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UP15_11730	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UP15_11735	COG2384	SAM-dependent methyltransferase
UP15_11740	COG2010	Cytochrome c
UP15_11745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UP15_11750	COG0358	DNA primase activity
UP15_11755	COG1671	Belongs to the UPF0178 family
UP15_11760	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UP15_11765	COG0517	IMP dehydrogenase activity
UP15_11770	COG0751	glycine-tRNA ligase activity
UP15_11775	COG0752	glycyl-tRNA synthetase alpha subunit
UP15_11780	COG1381	Involved in DNA repair and RecF pathway recombination
UP15_11785	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UP15_11790	COG0295	cytidine deaminase activity
UP15_11795	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UP15_11800	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UP15_11805	COG1480	7TM receptor with intracellular HD hydrolase
UP15_11810	COG1702	phosphate starvation-inducible protein PhoH
UP15_11815	COG0561	phosphatase activity
UP15_11835	COG4864	UPF0365 protein
UP15_11840	COG1030	water channel activity
UP15_11845	COG1610	YqeY-like protein
UP15_11850	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UP15_11855	COG1283	sodium-dependent phosphate transmembrane transporter activity
UP15_11860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP15_11865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UP15_11870	COG2264	protein methyltransferase activity
UP15_11875	COG0484	heat shock protein binding
UP15_11880	COG0443	Heat shock 70 kDa protein
UP15_11885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UP15_11890	COG1420	regulation of RNA biosynthetic process
UP15_11895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP15_11900	COG0481	GTPase activity
UP15_11910	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP15_11915	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UP15_11920	COG0268	Binds directly to 16S ribosomal RNA
UP15_11925	COG1466	dna polymerase III delta subunit
UP15_11935	COG2333	competence protein COMEC
UP15_11935	COG0658	competence protein
UP15_11940	COG2131	deaminase
UP15_11945	COG1555	photosystem II stabilization
UP15_11945	COG1596	polysaccharide export
UP15_11950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP15_11955	COG2226	methyltransferase
UP15_11960	COG0799	negative regulation of ribosome biogenesis
UP15_11965	COG1713	HD superfamily hydrolase involved in NAD metabolism
UP15_11970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UP15_11975	COG1534	Rna-binding protein
UP15_11980	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UP15_11985	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP15_11990	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
UP15_12000	COG2755	lipolytic protein G-D-S-L family
UP15_12010	COG0457	Tetratricopeptide repeat
UP15_12020	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UP15_12060	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP15_12060	COG3409	Peptidoglycan-binding domain 1 protein
UP15_12095	COG3778	Protein conserved in bacteria
UP15_12100	COG3299	homolog of phage Mu protein gp47
UP15_12105	COG3628	GPW Gp25 family protein
UP15_12115	COG4193	domain, Protein
UP15_12120	COG1652	LysM domain
UP15_12125	COG5280	Phage tail tape measure protein TP901
UP15_12125	COG3953	SLT domain
UP15_12125	COG3953	SLT domain
UP15_12125	COG5280	Phage tail tape measure protein TP901
UP15_12180	COG4653	Phage capsid family
UP15_12185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
UP15_12190	COG2369	cell adhesion
UP15_12195	COG5518	Phage portal protein
UP15_12200	COG1783	phage Terminase large subunit
UP15_12275	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
UP15_12285	COG0305	Participates in initiation and elongation during chromosome replication
UP15_12335	COG1396	sequence-specific DNA binding
UP15_12340	COG2856	Zn peptidase
UP15_12385	COG0726	polysaccharide deacetylase
UP15_12420	COG1131	(ABC) transporter
UP15_12445	COG2160	L-arabinose isomerase activity
UP15_12460	COG1609	Transcriptional regulator
UP15_12470	COG1846	Transcriptional regulator
UP15_12480	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
UP15_12485	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
UP15_12490	COG1733	regulation of RNA biosynthetic process
UP15_12525	COG2602	Beta-lactamase
UP15_12530	COG1960	acyl-CoA dehydrogenase activity
UP15_12535	COG1126	abc transporter atp-binding protein
UP15_12540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_12545	COG0765	amino acid transport
UP15_12555	COG3546	catalase activity
UP15_12560	COG1063	alcohol dehydrogenase
UP15_12570	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_12580	COG1115	amino acid carrier protein
UP15_12585	COG0583	DNA-binding transcription factor activity
UP15_12590	COG0842	Transport permease protein
UP15_12595	COG0842	Transport permease protein
UP15_12595	COG1511	domain protein
UP15_12600	COG1131	(ABC) transporter
UP15_12605	COG1063	alcohol dehydrogenase
UP15_12610	COG2226	methyltransferase
UP15_12620	COG0626	cystathionine gamma-synthase activity
UP15_12625	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP15_12630	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UP15_12635	COG2226	methyltransferase
UP15_12650	COG0768	penicillin binding
UP15_12655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UP15_12660	COG0572	uridine kinase
UP15_12680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UP15_12685	COG0183	Belongs to the thiolase family
UP15_12690	COG0318	PFAM AMP-dependent synthetase and ligase
UP15_12695	COG1268	BioY protein
UP15_12700	COG3906	Belongs to the UPF0473 family
UP15_12705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UP15_12710	COG4472	Bacterial protein of unknown function (DUF965)
UP15_12715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UP15_12720	COG0628	permease
UP15_12725	COG1126	abc transporter atp-binding protein
UP15_12730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_12735	COG0765	amino acid transport
UP15_12740	COG0765	amino acid transport
UP15_12750	COG3881	PFAM PRC-barrel domain
UP15_12755	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UP15_12760	COG0457	Tetratricopeptide repeat
UP15_12765	COG0482	sulfurtransferase activity
UP15_12770	COG1104	cysteine desulfurase activity
UP15_12775	COG1959	2 iron, 2 sulfur cluster binding
UP15_12780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UP15_12785	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UP15_12795	COG0124	histidyl-tRNA synthetase
UP15_12800	COG4991	sh3 domain protein
UP15_12800	COG3103	Sh3 type 3 domain protein
UP15_12800	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP15_12805	COG1490	D-aminoacyl-tRNA deacylase activity
UP15_12810	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UP15_12815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP15_12820	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
UP15_12820	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UP15_12825	COG5416	Lipopolysaccharide assembly protein A domain
UP15_12830	COG0490	domain, Protein
UP15_12835	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP15_12835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP15_12845	COG2244	polysaccharide biosynthetic process
UP15_12850	COG2323	membrane
UP15_12860	COG1862	Preprotein translocase
UP15_12865	COG0343	queuine tRNA-ribosyltransferase activity
UP15_12870	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UP15_12880	COG2255	four-way junction helicase activity
UP15_12885	COG0632	four-way junction helicase activity
UP15_12895	COG2112	serine threonine protein kinase
UP15_12905	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UP15_12920	COG1388	LysM domain
UP15_12925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UP15_12930	COG0157	Belongs to the NadC ModD family
UP15_12935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UP15_12940	COG1104	cysteine desulfurase activity
UP15_12945	COG1827	regulation of RNA biosynthetic process
UP15_12950	COG0077	Prephenate dehydratase
UP15_12955	COG4492	Belongs to the UPF0735 family
UP15_12960	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UP15_12965	COG3290	protein histidine kinase activity
UP15_12970	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UP15_12975	COG2868	ribosomal protein
UP15_12980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UP15_12985	COG1994	Peptidase M50
UP15_12990	COG0739	heme binding
UP15_12995	COG2894	cell division
UP15_13000	COG0850	regulation of cytokinetic process
UP15_13005	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
UP15_13010	COG1792	Involved in formation and maintenance of cell shape
UP15_13015	COG1077	Cell shape determining protein MreB Mrl
UP15_13020	COG2003	Belongs to the UPF0758 family
UP15_13025	COG0424	maF-like protein
UP15_13040	COG0285	dihydrofolate synthase activity
UP15_13045	COG0525	valine-tRNA ligase activity
UP15_13055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP15_13060	COG1388	LysM domain
UP15_13065	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP15_13070	COG0113	porphobilinogen synthase activity
UP15_13075	COG1587	Uroporphyrinogen-III synthase
UP15_13080	COG0181	hydroxymethylbilane synthase activity
UP15_13085	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP15_13090	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UP15_13110	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UP15_13115	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UP15_13120	COG0470	DNA polymerase III
UP15_13120	COG1067	ATP-dependent peptidase activity
UP15_13125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UP15_13130	COG0544	peptidyl-prolyl cis-trans isomerase activity
UP15_13135	COG1477	protein flavinylation
UP15_13135	COG0457	Tetratricopeptide repeat
UP15_13140	COG0066	3-isopropylmalate dehydratase activity
UP15_13145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UP15_13150	COG0473	3-isopropylmalate dehydrogenase activity
UP15_13155	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP15_13160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UP15_13165	COG0440	acetolactate synthase activity
UP15_13170	COG0028	Belongs to the TPP enzyme family
UP15_13175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP15_13180	COG2706	6-phosphogluconolactonase activity
UP15_13185	COG3339	Conserved Protein
UP15_13190	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
UP15_13195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP15_13200	COG1696	Membrane protein involved in D-alanine export
UP15_13205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP15_13245	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
UP15_13260	COG0622	Phosphoesterase
UP15_13265	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UP15_13270	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UP15_13275	COG5401	PFAM Sporulation and spore germination
UP15_13280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UP15_13285	COG1846	Transcriptional regulator
UP15_13290	COG2197	response regulator
UP15_13295	COG2851	Citrate transporter
UP15_13300	COG0583	DNA-binding transcription factor activity
UP15_13305	COG2828	Protein conserved in bacteria
UP15_13315	COG0824	Thioesterase
UP15_13320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UP15_13325	COG1053	succinate dehydrogenase
UP15_13330	COG2009	succinate dehydrogenase
UP15_13335	COG1719	4-vinyl reductase, 4VR
UP15_13340	COG0527	aspartate kinase activity
UP15_13345	COG0322	excinuclease ABC activity
UP15_13350	COG3118	belongs to the thioredoxin family
UP15_13355	COG3534	alpha-L-arabinofuranosidase
UP15_13360	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UP15_13365	COG2086	electron transfer activity
UP15_13370	COG1024	Enoyl-CoA hydratase
UP15_13375	COG1309	transcriptional regulator
UP15_13380	COG0318	PFAM AMP-dependent synthetase and ligase
UP15_13390	COG3766	membrane
UP15_13395	COG1193	negative regulation of DNA recombination
UP15_13400	COG1796	DNA polymerase
UP15_13400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP15_13405	COG1286	toxin biosynthetic process
UP15_13410	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
UP15_13415	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP15_13420	COG0072	phenylalanine-tRNA ligase activity
UP15_13420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP15_13425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UP15_13430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP15_13440	COG1966	Carbon starvation protein
UP15_13445	COG1363	Peptidase, m42
UP15_13455	COG3326	Membrane
UP15_13460	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UP15_13465	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UP15_13470	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UP15_13475	COG1346	cytolysis
UP15_13485	COG3279	Response regulator of the LytR AlgR family
UP15_13490	COG3275	phosphorelay sensor kinase activity
UP15_13505	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP15_13515	COG0398	Pfam SNARE associated Golgi protein
UP15_13520	COG1484	DNA-dependent DNA replication
UP15_13525	COG3611	Membrane attachment protein
UP15_13530	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UP15_13540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UP15_13545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP15_13550	COG0237	dephospho-CoA kinase activity
UP15_13555	COG1971	Probably functions as a manganese efflux pump
UP15_13560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UP15_13565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP15_13565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP15_13570	COG5002	protein histidine kinase activity
UP15_13575	COG0745	RESPONSE REGULATOR receiver
UP15_13580	COG0039	L-malate dehydrogenase activity
UP15_13585	COG0538	isocitrate dehydrogenase activity
UP15_13590	COG0372	Belongs to the citrate synthase family
UP15_13595	COG2707	UPF0756 membrane protein
UP15_13600	COG0628	permease
UP15_13605	COG3030	protein affecting phage T7 exclusion by the F plasmid
UP15_13615	COG0205	6-phosphofructokinase activity
UP15_13620	COG0825	malonyl-CoA metabolic process
UP15_13625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UP15_13630	COG0281	malic enzyme
UP15_13635	COG0587	DNA-directed DNA polymerase activity
UP15_13655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UP15_13665	COG4109	DRTGG domain
UP15_13670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP15_13675	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_13685	COG0165	Argininosuccinate lyase
UP15_13690	COG0137	argininosuccinate synthase activity
UP15_13695	COG0521	Mo-molybdopterin cofactor biosynthetic process
UP15_13700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UP15_13705	COG0827	DNA restriction-modification system
UP15_13710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UP15_13715	COG3874	Sporulation protein YtfJ
UP15_13725	COG1714	RDD family
UP15_13730	COG0616	signal peptide processing
UP15_13735	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP15_13745	COG3239	Fatty acid desaturase
UP15_13750	COG4585	Histidine kinase
UP15_13755	COG2197	response regulator
UP15_13760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_13765	COG0745	RESPONSE REGULATOR receiver
UP15_13770	COG2205	protein histidine kinase activity
UP15_13775	COG0772	Belongs to the SEDS family
UP15_13780	COG1695	Transcriptional regulator
UP15_13785	COG1136	(ABC) transporter
UP15_13790	COG0577	efflux transmembrane transporter activity
UP15_13795	COG0402	S-adenosylhomocysteine deaminase activity
UP15_13800	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP15_13815	COG1279	arginine transmembrane transporter activity
UP15_13820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP15_13830	COG0301	tRNA thio-modification
UP15_13835	COG1104	cysteine desulfurase activity
UP15_13840	COG1114	Component of the transport system for branched-chain amino acids
UP15_13845	COG1114	Component of the transport system for branched-chain amino acids
UP15_13850	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
UP15_13855	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP15_13860	COG1309	transcriptional regulator
UP15_13865	COG1956	GAF domain-containing protein
UP15_13870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UP15_13880	COG1335	isochorismatase
UP15_13890	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
UP15_13895	COG2329	Antibiotic biosynthesis monooxygenase
UP15_13900	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UP15_13905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP15_13910	COG0454	-acetyltransferase
UP15_13915	COG0517	IMP dehydrogenase activity
UP15_13920	COG0123	including yeast histone deacetylase and acetoin utilization protein
UP15_13925	COG1609	Transcriptional regulator
UP15_13930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
UP15_13930	COG1605	Chorismate mutase
UP15_13935	COG3118	belongs to the thioredoxin family
UP15_13940	COG4980	gas vesicle protein
UP15_13945	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
UP15_13950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UP15_13955	COG1674	ftsk spoiiie
UP15_13960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP15_13965	COG4848	Belongs to the UPF0354 family
UP15_13970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_13985	COG1363	Peptidase, m42
UP15_13990	COG5584	Small secreted protein
UP15_13995	COG0281	malic enzyme
UP15_14000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP15_14005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UP15_14015	COG0510	thiamine kinase activity
UP15_14020	COG1597	lipid kinase activity
UP15_14030	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UP15_14035	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP15_14040	COG3340	Belongs to the peptidase S51 family
UP15_14045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP15_14050	COG2252	PERMEase
UP15_14055	COG1349	DNA-binding transcription factor activity
UP15_14060	COG1187	pseudouridine synthase activity
UP15_14065	COG2244	polysaccharide biosynthetic process
UP15_14070	COG2081	HI0933 family
UP15_14080	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UP15_14085	COG3196	Protein conserved in bacteria
UP15_14095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP15_14100	COG5578	integral membrane protein
UP15_14105	COG0673	inositol 2-dehydrogenase activity
UP15_14110	COG1653	transport
UP15_14115	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
UP15_14120	COG4209	transmembrane transport
UP15_14125	COG2207	Transcriptional regulator
UP15_14130	COG1733	regulation of RNA biosynthetic process
UP15_14135	COG2814	Major facilitator Superfamily
UP15_14140	COG0656	L-ascorbic acid biosynthetic process
UP15_14145	COG1653	transport
UP15_14150	COG0395	ABC-type sugar transport system, permease component
UP15_14155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP15_14160	COG1073	alpha beta
UP15_14165	COG0495	leucyl-tRNA aminoacylation
UP15_14175	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_14175	COG2202	Pas domain
UP15_14185	COG2433	Pfam Transposase IS66
UP15_14190	COG0577	efflux transmembrane transporter activity
UP15_14195	COG1136	(ABC) transporter
UP15_14205	COG1131	(ABC) transporter
UP15_14210	COG1725	Transcriptional regulator
UP15_14235	COG1242	4 iron, 4 sulfur cluster binding
UP15_14240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
UP15_14245	COG4326	sporulation control protein
UP15_14255	COG2267	carboxylic ester hydrolase activity
UP15_14260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UP15_14265	COG0367	asparagine synthase
UP15_14270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UP15_14275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
UP15_14285	COG1506	peptidase
UP15_14290	COG1233	COG1233 Phytoene dehydrogenase and related
UP15_14310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP15_14315	COG1116	anion transmembrane transporter activity
UP15_14320	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP15_14325	COG0494	nUDIX hydrolase
UP15_14330	COG2310	stress, protein
UP15_14345	COG4824	toxin secretion phage lysis holin
UP15_14355	COG0783	Belongs to the Dps family
UP15_14370	COG1854	S-ribosylhomocysteine lyase activity
UP15_14375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UP15_14380	COG0288	reversible hydration of carbon dioxide
UP15_14385	COG0803	Belongs to the bacterial solute-binding protein 9 family
UP15_14385	COG3443	Belongs to the bacterial solute-binding protein 9 family
UP15_14395	COG1271	oxidase subunit
UP15_14400	COG1294	oxidase, subunit
UP15_14410	COG4948	Mandelate Racemase Muconate Lactonizing
UP15_14415	COG0318	PFAM AMP-dependent synthetase and ligase
UP15_14420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UP15_14425	COG0596	Alpha beta hydrolase
UP15_14430	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
UP15_14435	COG1169	isochorismate synthase
UP15_14440	COG1575	Belongs to the MenA family. Type 1 subfamily
UP15_14445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP15_14455	COG2801	Transposase and inactivated derivatives
UP15_14585	COG3859	Proton-coupled thiamine transporter YuaJ
UP15_14590	COG1247	-acetyltransferase
UP15_14595	COG3339	Conserved Protein
UP15_14600	COG0772	Belongs to the SEDS family
UP15_14605	COG0772	Belongs to the SEDS family
UP15_14610	COG2268	Band 7 protein
UP15_14615	COG1585	Membrane protein implicated in regulation of membrane protease activity
UP15_14620	COG2318	DinB family
UP15_14625	COG1454	alcohol dehydrogenase
UP15_14635	COG1510	regulation of RNA biosynthetic process
UP15_14650	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP15_14650	COG3409	Peptidoglycan-binding domain 1 protein
UP15_14715	COG3778	Protein conserved in bacteria
UP15_14720	COG3299	homolog of phage Mu protein gp47
UP15_14725	COG3628	GPW Gp25 family protein
UP15_14735	COG4193	domain, Protein
UP15_14740	COG1652	LysM domain
UP15_14745	COG5280	Phage tail tape measure protein TP901
UP15_14745	COG3953	SLT domain
UP15_14790	COG4653	Phage capsid family
UP15_14795	COG0338	D12 class N6 adenine-specific DNA methyltransferase
UP15_14800	COG5518	Phage portal protein
UP15_14805	COG1783	phage Terminase large subunit
UP15_14810	COG5484	DNA packaging
UP15_14815	COG1595	DNA-templated transcription, initiation
UP15_14825	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
UP15_14840	COG1396	sequence-specific DNA binding
UP15_14850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UP15_14865	COG0628	permease
UP15_14875	COG0673	inositol 2-dehydrogenase activity
UP15_14880	COG0693	protein deglycase activity
UP15_14885	COG0840	transmembrane signaling receptor activity
UP15_14890	COG0840	transmembrane signaling receptor activity
UP15_14895	COG0840	transmembrane signaling receptor activity
UP15_14900	COG0840	transmembrane signaling receptor activity
UP15_14915	COG2070	2-Nitropropane dioxygenase
UP15_14920	COG0432	Pfam Uncharacterised protein family UPF0047
UP15_14925	COG1253	flavin adenine dinucleotide binding
UP15_14930	COG2738	Putative neutral zinc metallopeptidase
UP15_14940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UP15_14955	COG0166	Belongs to the GPI family
UP15_14960	COG1979	alcohol dehydrogenase
UP15_14965	COG1979	alcohol dehydrogenase
UP15_14970	COG2155	Conserved Protein
UP15_14975	COG1098	S1 RNA binding domain
UP15_14980	COG0436	Aminotransferase
UP15_14985	COG1522	sequence-specific DNA binding
UP15_14990	COG2267	carboxylic ester hydrolase activity
UP15_15000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UP15_15005	COG2205	protein histidine kinase activity
UP15_15015	COG5018	Exonuclease
UP15_15020	COG2814	Major facilitator Superfamily
UP15_15025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP15_15030	COG3011	Protein conserved in bacteria
UP15_15040	COG3290	protein histidine kinase activity
UP15_15045	COG4565	transcriptional regulatory protein
UP15_15070	COG3493	citrate carrier protein
UP15_15085	COG2111	Na H antiporter
UP15_15085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UP15_15090	COG2111	Na H antiporter
UP15_15095	COG1006	Multisubunit Na H antiporter MnhC subunit
UP15_15100	COG0651	ATP synthesis coupled electron transport
UP15_15105	COG1863	multisubunit Na H antiporter MnhE subunit
UP15_15110	COG2212	antiporter activity
UP15_15115	COG1320	monovalent cation:proton antiporter activity
UP15_15120	COG2050	protein possibly involved in aromatic compounds catabolism
UP15_15125	COG2197	response regulator
UP15_15130	COG4585	Histidine kinase
UP15_15140	COG0142	geranyltranstransferase activity
UP15_15155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
UP15_15160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UP15_15165	COG1335	isochorismatase
UP15_15170	COG5506	Protein of unknown function (DUF1694)
UP15_15190	COG0628	permease
UP15_15205	COG1418	mRNA catabolic process
UP15_15210	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_15220	COG1511	domain protein
UP15_15225	COG1674	ftsk spoiiie
UP15_15225	COG0433	COG0433 Predicted ATPase
UP15_15230	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP15_15235	COG5417	Belongs to the EsaB family
UP15_15240	COG4842	Belongs to the WXG100 family
UP15_15245	COG2508	Transcriptional regulator
UP15_15245	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP15_15250	COG0686	Belongs to the AlaDH PNT family
UP15_15255	COG1268	BioY protein
UP15_15260	COG2056	Na+-H+ antiporter family
UP15_15265	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UP15_15270	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
UP15_15275	COG3584	3D domain protein
UP15_15285	COG1252	NADH dehydrogenase
UP15_15290	COG0492	ferredoxin-NADP+ reductase activity
UP15_15305	COG0789	Transcriptional regulator
UP15_15310	COG5504	Zn-dependent protease
UP15_15315	COG0316	Belongs to the HesB IscA family
UP15_15320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UP15_15325	COG4844	belongs to the
UP15_15330	COG1252	NADH dehydrogenase
UP15_15340	COG4837	Protein of unknown function (DUF1462)
UP15_15345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
UP15_15350	COG4946	Tricorn protease homolog
UP15_15350	COG1506	peptidase
UP15_15350	COG0823	Involved in the tonB-independent uptake of proteins
UP15_15355	COG0083	homoserine kinase activity
UP15_15360	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UP15_15365	COG0460	homoserine dehydrogenase
UP15_15370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP15_15375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP15_15380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP15_15385	COG0647	UMP catabolic process
UP15_15390	COG2445	Protein of unknown function DUF86
UP15_15395	COG4470	Protein conserved in bacteria
UP15_15405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UP15_15410	COG0739	heme binding
UP15_15430	COG3377	Domain of unknown function (DUF1805)
UP15_15435	COG0737	Belongs to the 5'-nucleotidase family
UP15_15440	COG1801	Protein of unknown function DUF72
UP15_15445	COG2508	Transcriptional regulator
UP15_15450	COG2140	Oxalate decarboxylase
UP15_15455	COG2814	Major facilitator Superfamily
UP15_15460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
UP15_15465	COG2356	endonuclease I
UP15_15475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_15480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_15485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_15505	COG0642	Histidine kinase
UP15_15505	COG5002	protein histidine kinase activity
UP15_15510	COG0745	RESPONSE REGULATOR receiver
UP15_15515	COG2311	Membrane
UP15_15525	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP15_15530	COG1090	epimerase
UP15_15540	COG0719	Fe-S assembly protein
UP15_15545	COG0822	iron-sulfur transferase activity
UP15_15550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UP15_15555	COG0719	Fe-S assembly protein
UP15_15560	COG0396	ATPase activity
UP15_15565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UP15_15570	COG1464	Belongs to the NlpA lipoprotein family
UP15_15575	COG2011	ABC-type metal ion transport system permease component
UP15_15580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UP15_15590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_15595	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UP15_15605	COG0509	glycine decarboxylation via glycine cleavage system
UP15_15610	COG1393	Belongs to the ArsC family
UP15_15615	COG1960	acyl-CoA dehydrogenase activity
UP15_15620	COG0183	Belongs to the thiolase family
UP15_15625	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP15_15625	COG1024	Enoyl-CoA hydratase
UP15_15635	COG5577	PFAM Coat F domain
UP15_15645	COG1120	ATPase activity
UP15_15655	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_15660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP15_15665	COG0745	RESPONSE REGULATOR receiver
UP15_15670	COG2205	protein histidine kinase activity
UP15_15670	COG2770	Histidine kinase
UP15_15675	COG1309	transcriptional regulator
UP15_15680	COG0114	fumarate hydratase activity
UP15_15685	COG0697	spore germination
UP15_15690	COG0814	amino acid
UP15_15705	COG2197	response regulator
UP15_15710	COG4585	Histidine kinase
UP15_15715	COG4758	membrane
UP15_15725	COG1842	Phage shock protein A
UP15_15730	COG4758	membrane
UP15_15735	COG2096	Adenosyltransferase
UP15_15740	COG1120	ATPase activity
UP15_15745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_15750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_15760	COG2721	sulfolactate sulfo-lyase activity
UP15_15765	COG0246	Mannitol dehydrogenase
UP15_15770	COG1609	Transcriptional regulator
UP15_15775	COG1904	glucuronate isomerase
UP15_15780	COG2205	protein histidine kinase activity
UP15_15785	COG0745	RESPONSE REGULATOR receiver
UP15_15790	COG1120	ATPase activity
UP15_15795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_15800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_15805	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_15810	COG0531	amino acid
UP15_15825	COG1988	membrane-bound metal-dependent
UP15_15830	COG1368	sulfuric ester hydrolase activity
UP15_15835	COG0725	ABC transporter, periplasmic molybdate-binding protein
UP15_15840	COG4149	molybdate abc transporter
UP15_15845	COG0656	L-ascorbic acid biosynthetic process
UP15_15850	COG1940	carbohydrate kinase activity
UP15_15855	COG0025	NhaP-type Na H and K H
UP15_15860	COG2860	membrane
UP15_15865	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
UP15_15870	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UP15_15875	COG2217	Heavy metal translocating P-type atpase
UP15_15880	COG1121	(ABC) transporter
UP15_15885	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UP15_15890	COG0803	Belongs to the bacterial solute-binding protein 9 family
UP15_15900	COG3226	Transcriptional regulator
UP15_15905	COG0784	Response regulator, receiver
UP15_15910	COG4191	Histidine kinase
UP15_15915	COG1027	Aspartate ammonia-lyase
UP15_15925	COG2217	Heavy metal translocating P-type atpase
UP15_15930	COG2608	mercury ion transmembrane transporter activity
UP15_15935	COG1937	Protein conserved in bacteria
UP15_15945	COG3706	GGDEF domain
UP15_15945	COG0745	RESPONSE REGULATOR receiver
UP15_15955	COG0463	Glycosyl transferase, family 2
UP15_15955	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP15_15960	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UP15_15965	COG0557	exoribonuclease II activity
UP15_15970	COG1647	Serine aminopeptidase, S33
UP15_15975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP15_15980	COG2002	toxin-antitoxin pair type II binding
UP15_15985	COG1476	TRANSCRIPTIONal
UP15_15990	COG1396	sequence-specific DNA binding
UP15_15995	COG1396	sequence-specific DNA binding
UP15_16000	COG1733	regulation of RNA biosynthetic process
UP15_16005	COG1174	glycine betaine transport
UP15_16010	COG1732	Glycine betaine
UP15_16015	COG1174	glycine betaine transport
UP15_16020	COG0517	IMP dehydrogenase activity
UP15_16020	COG1125	glycine betaine transport
UP15_16025	COG1510	regulation of RNA biosynthetic process
UP15_16030	COG2095	MarC family integral membrane protein
UP15_16040	COG0456	acetyltransferase
UP15_16060	COG1131	(ABC) transporter
UP15_16070	COG0148	phosphopyruvate hydratase activity
UP15_16075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
UP15_16080	COG0149	triose-phosphate isomerase activity
UP15_16085	COG0126	phosphoglycerate kinase activity
UP15_16090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP15_16095	COG2390	Transcriptional regulator
UP15_16100	COG0833	amino acid
UP15_16105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UP15_16110	COG3829	transcription factor binding
UP15_16115	COG2186	Transcriptional regulator
UP15_16120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UP15_16130	COG0534	Mate efflux family protein
UP15_16135	COG4608	Belongs to the ABC transporter superfamily
UP15_16140	COG0444	Belongs to the ABC transporter superfamily
UP15_16145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP15_16150	COG0601	transmembrane transport
UP15_16155	COG0747	negative chemotaxis
UP15_16160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UP15_16165	COG0110	maltose O-acetyltransferase activity
UP15_16170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UP15_16175	COG2244	polysaccharide biosynthetic process
UP15_16180	COG5039	Polysaccharide pyruvyl transferase
UP15_16185	COG1216	Glycosyl transferase, family 2
UP15_16195	COG0438	transferase activity, transferring glycosyl groups
UP15_16200	COG1215	transferase activity, transferring glycosyl groups
UP15_16205	COG0438	transferase activity, transferring glycosyl groups
UP15_16210	COG1086	Polysaccharide biosynthesis protein
UP15_16215	COG0489	protein tyrosine kinase activity
UP15_16220	COG3944	biosynthesis protein
UP15_16225	COG1396	sequence-specific DNA binding
UP15_16235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_16240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_16245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_16250	COG0726	polysaccharide deacetylase
UP15_16260	COG1124	(ABC) transporter
UP15_16275	COG0601	transmembrane transport
UP15_16280	COG0747	negative chemotaxis
UP15_16285	COG1819	glycosyl
UP15_16290	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_16305	COG0740	serine-type endopeptidase activity
UP15_16310	COG1611	Belongs to the LOG family
UP15_16315	COG1694	Mazg nucleotide pyrophosphohydrolase
UP15_16320	COG0659	secondary active sulfate transmembrane transporter activity
UP15_16325	COG0288	reversible hydration of carbon dioxide
UP15_16330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP15_16340	COG2162	N-hydroxyarylamine O-acetyltransferase activity
UP15_16345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_16350	COG1481	regulation of sporulation
UP15_16355	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UP15_16360	COG1660	Displays ATPase and GTPase activities
UP15_16365	COG1051	belongs to the nudix hydrolase family
UP15_16370	COG0492	ferredoxin-NADP+ reductase activity
UP15_16375	COG0791	NLP P60 protein
UP15_16375	COG3883	PFAM NLP P60 protein
UP15_16380	COG0457	Tetratricopeptide repeat
UP15_16385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UP15_16385	COG0140	phosphoribosyl-ATP diphosphatase activity
UP15_16390	COG0107	imidazoleglycerol-phosphate synthase activity
UP15_16395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UP15_16400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UP15_16405	COG0131	Imidazoleglycerol-phosphate dehydratase
UP15_16410	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UP15_16415	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UP15_16420	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
UP15_16425	COG4990	cell redox homeostasis
UP15_16430	COG2910	NAD(P)H-binding
UP15_16435	COG1959	2 iron, 2 sulfur cluster binding
UP15_16440	COG0110	maltose O-acetyltransferase activity
UP15_16445	COG0546	phosphoglycolate phosphatase activity
UP15_16450	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UP15_16455	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UP15_16460	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
UP15_16465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP15_16470	COG0363	glucosamine-6-phosphate deaminase activity
UP15_16480	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UP15_16485	COG1950	PFAM Membrane protein of
UP15_16490	COG1983	PspC domain protein
UP15_16495	COG3595	metallopeptidase activity
UP15_16510	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UP15_16520	COG4897	Protein conserved in bacteria
UP15_16525	COG0574	Belongs to the PEP-utilizing enzyme family
UP15_16525	COG3848	Pyruvate phosphate dikinase
UP15_16530	COG1309	transcriptional regulator
UP15_16535	COG2814	Major facilitator Superfamily
UP15_16545	COG0745	RESPONSE REGULATOR receiver
UP15_16550	COG5002	protein histidine kinase activity
UP15_16555	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
UP15_16560	COG0463	Glycosyl transferase, family 2
UP15_16565	COG1113	amino acid transport
UP15_16570	COG0778	Nitroreductase
UP15_16575	COG1733	regulation of RNA biosynthetic process
UP15_16580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP15_16590	COG0793	Belongs to the peptidase S41A family
UP15_16590	COG3409	Peptidoglycan-binding domain 1 protein
UP15_16595	COG0730	response to heat
UP15_16600	COG0791	NLP P60 protein
UP15_16600	COG3883	PFAM NLP P60 protein
UP15_16605	COG2177	Part of the ABC transporter FtsEX involved in
UP15_16610	COG2884	Cell division ATP-binding protein ftsE
UP15_16615	COG2010	Cytochrome c
UP15_16620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP15_16635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UP15_16640	COG0653	protein targeting
UP15_16645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UP15_16650	COG0840	transmembrane signaling receptor activity
UP15_16665	COG1516	flagellar protein fliS
UP15_16670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UP15_16675	COG1334	flagellar protein FlaG
UP15_16680	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UP15_16685	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UP15_16695	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP15_16700	COG4786	Flagellar basal body rod
UP15_16700	COG1256	bacterial-type flagellum assembly
UP15_16705	COG3418	PFAM FlgN family protein
UP15_16720	COG1040	competence protein
UP15_16730	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
UP15_16735	COG1307	EDD domain protein, DegV family
UP15_16740	COG2197	response regulator
UP15_16745	COG4585	Histidine kinase
UP15_16750	COG1739	Uncharacterized protein family UPF0029
UP15_16760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP15_16765	COG0438	transferase activity, transferring glycosyl groups
UP15_16770	COG1215	transferase activity, transferring glycosyl groups
UP15_16775	COG3206	protein involved in exopolysaccharide biosynthesis
UP15_16780	COG3307	-O-antigen
UP15_16785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP15_16790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UP15_16795	COG0438	transferase activity, transferring glycosyl groups
UP15_16795	COG0297	glycogen (starch) synthase activity
UP15_16800	COG2244	polysaccharide biosynthetic process
UP15_16815	COG2247	cell wall binding repeat
UP15_16815	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP15_16820	COG2247	cell wall binding repeat
UP15_16820	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP15_16825	COG2247	cell wall binding repeat
UP15_16825	COG2385	sporulation resulting in formation of a cellular spore
UP15_16835	COG1316	TRANSCRIPTIONal
UP15_16840	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UP15_16845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP15_16850	COG1134	teichoic acid transport
UP15_16855	COG1682	transport, permease protein
UP15_16860	COG1215	transferase activity, transferring glycosyl groups
UP15_16895	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UP15_16900	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
UP15_16905	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP15_16910	COG4193	domain, Protein
UP15_16915	COG1482	cell wall glycoprotein biosynthetic process
UP15_16925	COG1175	transmembrane transport
UP15_16930	COG1653	transport
UP15_16935	COG2197	response regulator
UP15_16940	COG2972	Histidine kinase
UP15_16950	COG0454	-acetyltransferase
UP15_16955	COG0800	Aldolase
UP15_16960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP15_16965	COG1609	Transcriptional regulator
UP15_16970	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
UP15_16975	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_16980	COG0697	spore germination
UP15_16985	COG0814	amino acid
UP15_17000	COG2814	Major facilitator Superfamily
UP15_17005	COG1316	TRANSCRIPTIONal
UP15_17010	COG0561	phosphatase activity
UP15_17015	COG0791	NLP P60 protein
UP15_17020	COG2843	Capsule synthesis protein
UP15_17030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UP15_17035	COG0697	spore germination
UP15_17050	COG1609	Transcriptional regulator
UP15_17055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP15_17060	COG1869	D-ribose catabolic process
UP15_17065	COG1129	ABC transporter
UP15_17070	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP15_17075	COG1879	ABC-type sugar transport system periplasmic component
UP15_17080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UP15_17085	COG0583	DNA-binding transcription factor activity
UP15_17090	COG0028	Belongs to the TPP enzyme family
UP15_17095	COG3527	Alpha-acetolactate decarboxylase
UP15_17100	COG1522	sequence-specific DNA binding
UP15_17105	COG2059	Chromate
UP15_17110	COG2059	Chromate
UP15_17115	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UP15_17120	COG4715	Zinc finger, swim domain protein
UP15_17125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP15_17130	COG1366	Belongs to the anti-sigma-factor antagonist family
UP15_17130	COG2202	Pas domain
UP15_17135	COG0561	phosphatase activity
UP15_17150	COG1970	mechanosensitive ion channel activity
UP15_17155	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UP15_17160	COG0457	Tetratricopeptide repeat
UP15_17165	COG4786	Flagellar basal body rod
UP15_17170	COG4786	Flagellar basal body rod
UP15_17175	COG1077	Cell shape determining protein MreB Mrl
UP15_17180	COG1609	Transcriptional regulator
UP15_17185	COG1846	Transcriptional regulator
UP15_17190	COG2814	Major facilitator Superfamily
UP15_17195	COG0671	phosphoesterase, PA-phosphatase related
UP15_17200	COG0477	Major facilitator Superfamily
UP15_17205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_17210	COG0765	amino acid transport
UP15_17215	COG1126	abc transporter atp-binding protein
UP15_17220	COG0004	ammonium transporteR
UP15_17225	COG0347	Belongs to the P(II) protein family
UP15_17230	COG0739	heme binding
UP15_17235	COG1247	-acetyltransferase
UP15_17245	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UP15_17250	COG0523	cobalamin synthesis protein
UP15_17255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP15_17260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UP15_17265	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UP15_17280	COG2304	oxidoreductase activity
UP15_17285	COG2304	oxidoreductase activity
UP15_17290	COG2385	sporulation resulting in formation of a cellular spore
UP15_17295	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UP15_17305	COG4836	Membrane
UP15_17315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UP15_17320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UP15_17325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UP15_17330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UP15_17335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP15_17340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UP15_17345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP15_17350	COG0356	it plays a direct role in the translocation of protons across the membrane
UP15_17360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UP15_17365	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UP15_17370	COG4475	Protein of unknown function (DUF436)
UP15_17375	COG0698	ribose 5-phosphate isomerase
UP15_17380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP15_17385	COG1971	Probably functions as a manganese efflux pump
UP15_17390	COG0009	L-threonylcarbamoyladenylate synthase
UP15_17395	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UP15_17410	COG2890	protein-(glutamine-N5) methyltransferase activity
UP15_17415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UP15_17420	COG0789	Transcriptional regulator
UP15_17425	COG0679	Auxin Efflux Carrier
UP15_17430	COG0281	malic enzyme
UP15_17435	COG1435	thymidine kinase activity
UP15_17440	COG0254	rRNA binding
UP15_17445	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UP15_17450	COG1494	fructose-1,6-bisphosphatase
UP15_17455	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UP15_17460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UP15_17465	COG0191	fructose-bisphosphate aldolase activity
UP15_17470	COG2204	response regulator
UP15_17475	COG4821	SIS domain
UP15_17480	COG0504	CTP synthase activity
UP15_17485	COG3343	RNA polymerase activity
UP15_17525	COG1960	acyl-CoA dehydrogenase activity
UP15_17530	COG1960	acyl-CoA dehydrogenase activity
UP15_17535	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP15_17540	COG0183	Belongs to the thiolase family
UP15_17545	COG0247	lactate metabolic process
UP15_17545	COG2181	nitrate reductase activity
UP15_17550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP15_17555	COG4294	response to UV
UP15_17565	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP15_17575	COG1132	(ABC) transporter
UP15_17580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP15_17585	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP15_17600	COG0018	arginyl-trna synthetase
UP15_17605	COG4506	Protein conserved in bacteria
UP15_17615	COG0010	Belongs to the arginase family
UP15_17620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UP15_17625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP15_17635	COG1994	Peptidase M50
UP15_17640	COG1942	4-Oxalocrotonate Tautomerase
UP15_17650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP15_17655	COG0583	DNA-binding transcription factor activity
UP15_17660	COG0431	NADPH-dependent FMN reductase
UP15_17665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP15_17670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
UP15_17675	COG0454	-acetyltransferase
UP15_17680	COG0765	amino acid transport
UP15_17690	COG0765	amino acid transport
UP15_17695	COG1126	abc transporter atp-binding protein
UP15_17700	COG3465	dGTPase activity
UP15_17705	COG1078	dGTPase activity
UP15_17710	COG4844	belongs to the
UP15_17760	COG5444	nuclease activity
UP15_17800	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UP15_17810	COG0280	phosphate acetyltransferase
UP15_17820	COG1073	alpha beta
UP15_17825	COG1522	sequence-specific DNA binding
UP15_17830	COG2814	Major facilitator Superfamily
UP15_17835	COG0077	Prephenate dehydratase
UP15_17840	COG1917	Cupin 2, conserved barrel domain protein
UP15_17845	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_17850	COG0151	Belongs to the GarS family
UP15_17855	COG0436	Aminotransferase
UP15_17860	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_17865	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
UP15_17870	COG1091	dTDP-4-dehydrorhamnose reductase activity
UP15_17875	COG1088	dTDP-glucose 4,6-dehydratase activity
UP15_17880	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UP15_17885	COG3980	spore coat polysaccharide biosynthesis protein
UP15_17890	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
UP15_17895	COG2089	acid synthase
UP15_17900	COG0456	acetyltransferase
UP15_17905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UP15_17910	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP15_17915	COG0463	Glycosyl transferase, family 2
UP15_17935	COG2363	Small membrane protein
UP15_17940	COG2233	PERMEase
UP15_17950	COG1012	belongs to the aldehyde dehydrogenase family
UP15_17955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UP15_17960	COG1216	Glycosyl transferase, family 2
UP15_17970	COG0351	phosphomethylpyrimidine kinase
UP15_17995	COG1621	beta-fructofuranosidase activity
UP15_18000	COG1263	PTS System
UP15_18000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_18005	COG3711	transcriptional antiterminator
UP15_18015	COG1404	Belongs to the peptidase S8 family
UP15_18025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP15_18030	COG0778	Nitroreductase
UP15_18035	COG0772	Belongs to the SEDS family
UP15_18045	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UP15_18050	COG1845	cytochrome c oxidase, subunit III
UP15_18055	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UP15_18060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UP15_18070	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
UP15_18075	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UP15_18080	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
UP15_18095	COG2246	polysaccharide biosynthetic process
UP15_18125	COG0457	Tetratricopeptide repeat
UP15_18145	COG3162	membrane
UP15_18150	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP15_18160	COG2801	Transposase and inactivated derivatives
UP15_18175	COG0352	thiamine-phosphate diphosphorylase activity
UP15_18180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
UP15_18185	COG0583	DNA-binding transcription factor activity
UP15_18190	COG1380	Effector of murein hydrolase LrgA
UP15_18195	COG1346	cytolysis
UP15_18200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UP15_18205	COG0346	lactoylglutathione lyase activity
UP15_18215	COG0765	amino acid transport
UP15_18220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP15_18230	COG0457	Tetratricopeptide repeat
UP15_18235	COG2357	RelA SpoT domain protein
UP15_18240	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP15_18245	COG1129	ABC transporter
UP15_18255	COG3420	alginic acid biosynthetic process
UP15_18260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP15_18275	COG1486	melibiose metabolic process
UP15_18280	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP15_18285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP15_18290	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP15_18295	COG3711	transcriptional antiterminator
UP15_18295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_18310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP15_18325	COG1595	DNA-templated transcription, initiation
UP15_18330	COG3866	Pectate lyase
UP15_18335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UP15_18340	COG4988	ABC transporter
UP15_18345	COG1294	oxidase, subunit
UP15_18350	COG1271	oxidase subunit
UP15_18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP15_18365	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
UP15_18370	COG4509	Sortase family
UP15_18390	COG5386	Cell surface protein
UP15_18395	COG5386	Cell surface protein
UP15_18400	COG5386	Cell surface protein
UP15_18405	COG1733	regulation of RNA biosynthetic process
UP15_18410	COG2514	catechol 2,3-dioxygenase activity
UP15_18415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP15_18415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP15_18420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP15_18420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP15_18430	COG0726	polysaccharide deacetylase
UP15_18435	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP15_18440	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP15_18445	COG2723	6-phospho-beta-galactosidase activity
UP15_18450	COG1312	Catalyzes the dehydration of D-mannonate
UP15_18455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP15_18460	COG3711	transcriptional antiterminator
UP15_18460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP15_18485	COG1757	Na H antiporter
UP15_18490	COG1027	Aspartate ammonia-lyase
UP15_18495	COG0252	asparaginase activity
UP15_18500	COG1396	sequence-specific DNA binding
UP15_18525	COG4842	Belongs to the WXG100 family
UP15_18530	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP15_18545	COG1737	Transcriptional regulator
UP15_18550	COG2084	Dehydrogenase
UP15_18560	COG2610	gluconate transmembrane transporter activity
UP15_18565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UP15_18590	COG2723	6-phospho-beta-galactosidase activity
UP15_18595	COG2190	(PTS) system
UP15_18595	COG1263	PTS System
UP15_18595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_18600	COG3711	transcriptional antiterminator
UP15_18610	COG3878	Protein conserved in bacteria
UP15_18620	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP15_18625	COG1122	ATPase activity
UP15_18630	COG4721	ABC-type cobalt transport system, permease component
UP15_18635	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP15_18660	COG4412	M6 family metalloprotease domain protein
UP15_18660	COG3291	Pkd domain containing protein
UP15_18665	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
UP15_18670	COG0778	Nitroreductase
UP15_18675	COG1846	Transcriptional regulator
UP15_18680	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
UP15_18685	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UP15_18690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
UP15_18695	COG2390	Transcriptional regulator
UP15_18705	COG2755	lipolytic protein G-D-S-L family
UP15_18705	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UP15_18710	COG0477	Major facilitator Superfamily
UP15_18720	COG2226	methyltransferase
UP15_18730	COG0561	phosphatase activity
UP15_18735	COG0789	Transcriptional regulator
UP15_18740	COG0673	inositol 2-dehydrogenase activity
UP15_18745	COG0840	transmembrane signaling receptor activity
UP15_18750	COG1113	amino acid transport
UP15_18755	COG4335	DNA alkylation repair
UP15_18765	COG1070	Carbohydrate kinase
UP15_18770	COG1737	Transcriptional regulator
UP15_18810	COG0583	DNA-binding transcription factor activity
UP15_18815	COG1609	Transcriptional regulator
UP15_18820	COG2182	Extracellular solute-binding protein
UP15_18825	COG1175	transmembrane transport
UP15_18830	COG3833	ABC-type maltose transport systems, permease component
UP15_18840	COG1874	Beta-galactosidase
UP15_18875	COG2851	Citrate transporter
UP15_18885	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP15_18890	COG1131	(ABC) transporter
UP15_18895	COG2824	Alkylphosphonate utilization operon protein PhnA
UP15_18900	COG1929	Belongs to the glycerate kinase type-1 family
UP15_18905	COG2610	gluconate transmembrane transporter activity
UP15_18910	COG3835	regulator
UP15_18915	COG1309	transcriptional regulator
UP15_18920	COG2814	Major facilitator Superfamily
UP15_18930	COG1136	(ABC) transporter
UP15_18940	COG0457	Tetratricopeptide repeat
UP15_18945	COG3711	transcriptional antiterminator
UP15_18950	COG2723	6-phospho-beta-galactosidase activity
UP15_18955	COG2190	(PTS) system
UP15_18955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_18955	COG1263	PTS System
UP15_18980	COG0494	nUDIX hydrolase
UP15_18995	COG1113	amino acid transport
UP15_19005	COG2814	Major facilitator Superfamily
UP15_19010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UP15_19015	COG2814	Major facilitator Superfamily
UP15_19030	COG5444	nuclease activity
UP15_19045	COG2723	6-phospho-beta-galactosidase activity
UP15_19050	COG1263	PTS System
UP15_19050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP15_19050	COG2190	(PTS) system
UP15_19055	COG2188	Transcriptional regulator
UP15_19065	COG0384	phenazine biosynthesis protein PhzF
UP15_19070	COG0583	DNA-binding transcription factor activity
UP15_19090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UP15_19095	COG3850	Histidine kinase
UP15_19095	COG5002	protein histidine kinase activity
UP15_19105	COG2409	Drug exporters of the RND superfamily
UP15_19110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP15_19130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UP15_19135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP15_19145	COG4720	Psort location CytoplasmicMembrane, score
UP15_19165	COG0456	acetyltransferase
UP15_19170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP15_19175	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UP15_19180	COG4853	Protein conserved in bacteria
UP15_19185	COG4863	YycH protein
UP15_19190	COG5002	protein histidine kinase activity
UP15_19195	COG0745	RESPONSE REGULATOR receiver
UP15_19220	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP15_19230	COG2311	Membrane
UP15_19235	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UP15_19240	COG1309	transcriptional regulator
UP15_19245	COG2124	cytochrome p450
UP15_19250	COG0346	lactoylglutathione lyase activity
UP15_19255	COG0305	Participates in initiation and elongation during chromosome replication
UP15_19270	COG2819	hydrolase of the alpha beta superfamily
UP15_19275	COG1028	Short-chain dehydrogenase reductase Sdr
UP15_19280	COG1169	isochorismate synthase
UP15_19285	COG1021	2,3-dihydroxybenzoate-AMP ligase
UP15_19290	COG1535	isochorismatase
UP15_19290	COG3433	isochorismatase activity
UP15_19295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP15_19300	COG3251	PFAM MbtH domain protein
UP15_19305	COG2207	Transcriptional regulator
UP15_19305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_19310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP15_19315	COG2819	hydrolase of the alpha beta superfamily
UP15_19320	COG2807	transmembrane transport
UP15_19325	COG0359	binds to the 23S rRNA
UP15_19330	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
UP15_19335	COG4241	membrane
UP15_19340	COG1227	inorganic diphosphatase activity
UP15_19350	COG1595	DNA-templated transcription, initiation
UP15_19360	COG0753	catalase activity
UP15_19365	COG0655	NAD(P)H dehydrogenase (quinone) activity
UP15_19370	COG0400	carboxylic ester hydrolase activity
UP15_19375	COG0346	lactoylglutathione lyase activity
UP15_19380	COG1174	glycine betaine transport
UP15_19385	COG0517	IMP dehydrogenase activity
UP15_19385	COG1125	glycine betaine transport
UP15_19390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UP15_19395	COG0629	single-stranded DNA binding
UP15_19400	COG0360	Binds together with S18 to 16S ribosomal RNA
UP15_19405	COG0012	GTP binding
UP15_19410	COG4481	Protein conserved in bacteria
UP15_19425	COG3949	Membrane
UP15_19435	COG1475	DNA binding
UP15_19440	COG1192	Involved in chromosome partitioning
UP15_19450	COG1475	DNA binding
UP15_19455	COG0357	Ribosomal RNA small subunit methyltransferase G
UP15_19460	COG0445	tRNA wobble uridine modification
UP15_19465	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UP15_19470	COG1847	R3H domain protein
UP15_19475	COG0706	membrane insertase activity
UP15_19480	COG0594	ribonuclease P activity