locus-tag	class	description
UP12_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UP12_00010	COG0592	DNA-directed DNA polymerase activity
UP12_00015	COG2501	S4 domain
UP12_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UP12_00030	COG0187	DNA topoisomerase II activity
UP12_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP12_00070	COG0517	IMP dehydrogenase activity
UP12_00070	COG0516	GMP reductase activity
UP12_00075	COG1686	Belongs to the peptidase S11 family
UP12_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP12_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UP12_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
UP12_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
UP12_00100	COG0840	transmembrane signaling receptor activity
UP12_00110	COG1428	Deoxynucleoside kinase
UP12_00115	COG1428	Deoxynucleoside kinase
UP12_00120	COG1388	LysM domain
UP12_00120	COG3858	chitin binding
UP12_00125	COG1335	isochorismatase
UP12_00130	COG0590	tRNA wobble adenosine to inosine editing
UP12_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UP12_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UP12_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UP12_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
UP12_00195	COG3853	Toxic anion resistance protein (TelA)
UP12_00200	COG1982	Orn Lys Arg decarboxylase major
UP12_00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UP12_00210	COG3870	Protein conserved in bacteria
UP12_00215	COG1728	Protein conserved in bacteria
UP12_00220	COG0470	DNA polymerase III
UP12_00225	COG1774	PSP1 C-terminal conserved region
UP12_00230	COG4467	Involved in initiation control of chromosome replication
UP12_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UP12_00240	COG2827	Endonuclease containing a URI domain
UP12_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UP12_00250	COG2002	toxin-antitoxin pair type II binding
UP12_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP12_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP12_00260	COG0084	hydrolase, TatD family'
UP12_00265	COG3583	domain protein
UP12_00265	COG3584	3D domain protein
UP12_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UP12_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UP12_00285	COG4466	Protein conserved in bacteria
UP12_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
UP12_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP12_00305	COG0251	oxidation-reduction process
UP12_00310	COG2088	sporulation resulting in formation of a cellular spore
UP12_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UP12_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UP12_00330	COG0193	aminoacyl-tRNA hydrolase activity
UP12_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UP12_00345	COG2002	toxin-antitoxin pair type II binding
UP12_00350	COG2244	polysaccharide biosynthetic process
UP12_00355	COG3956	TIGRFAM MazG family protein
UP12_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UP12_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
UP12_00380	COG1098	S1 RNA binding domain
UP12_00395	COG2208	phosphoserine phosphatase activity
UP12_00400	COG2304	oxidoreductase activity
UP12_00405	COG0515	serine threonine protein kinase
UP12_00410	COG0037	tRNA processing
UP12_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UP12_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UP12_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UP12_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP12_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP12_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UP12_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
UP12_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP12_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UP12_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UP12_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UP12_00475	COG1396	sequence-specific DNA binding
UP12_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP12_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UP12_00565	COG4463	regulation of RNA biosynthetic process
UP12_00570	COG3880	PFAM UvrB UvrC protein
UP12_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
UP12_00580	COG0542	response to heat
UP12_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UP12_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
UP12_00595	COG4956	integral membrane protein (PIN domain superfamily)
UP12_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UP12_00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UP12_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UP12_00615	COG1045	serine acetyltransferase
UP12_00620	COG0215	cysteine-tRNA ligase activity
UP12_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
UP12_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP12_00635	COG3688	RNA-binding protein containing a PIN domain
UP12_00640	COG1595	DNA-templated transcription, initiation
UP12_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP12_00650	COG0250	Participates in transcription elongation, termination and antitermination
UP12_00655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UP12_00660	COG0081	regulation of translation
UP12_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UP12_00670	COG0222	ribosome binding
UP12_00675	COG2813	Specifically methylates the guanine in position
UP12_00680	COG0085	RNA polymerase activity
UP12_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UP12_00690	COG1358	cellular component organization or biogenesis
UP12_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UP12_00700	COG0049	tRNA binding
UP12_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UP12_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UP12_00715	COG0596	Alpha beta hydrolase
UP12_00720	COG0051	transcription antitermination factor activity, RNA binding
UP12_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UP12_00730	COG0088	Forms part of the polypeptide exit tunnel
UP12_00735	COG0089	rRNA binding
UP12_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UP12_00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UP12_00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UP12_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UP12_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UP12_00765	COG0255	Belongs to the universal ribosomal protein uL29 family
UP12_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UP12_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UP12_00780	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UP12_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UP12_00790	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP12_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UP12_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UP12_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UP12_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UP12_00815	COG1841	ribosomal large subunit assembly
UP12_00820	COG0200	Binds to the 23S rRNA
UP12_00825	COG0201	protein transport
UP12_00830	COG0563	adenylate kinase activity
UP12_00835	COG0024	Methionine aminopeptidase
UP12_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
UP12_00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UP12_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UP12_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UP12_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UP12_00865	COG0202	RNA polymerase activity
UP12_00870	COG0203	ribosomal protein L17
UP12_00875	COG1122	ATPase activity
UP12_00880	COG1122	ATPase activity
UP12_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP12_00890	COG0101	tRNA pseudouridine synthase activity
UP12_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UP12_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UP12_00905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP12_00935	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP12_00940	COG0489	protein tyrosine kinase activity
UP12_00950	COG2194	sulfuric ester hydrolase activity
UP12_00955	COG0726	polysaccharide deacetylase
UP12_00985	COG0659	secondary active sulfate transmembrane transporter activity
UP12_00990	COG0385	Bile acid
UP12_00995	COG3876	Protein conserved in bacteria
UP12_01000	COG1472	Belongs to the glycosyl hydrolase 3 family
UP12_01005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UP12_01010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_01010	COG1263	PTS System
UP12_01015	COG1737	Transcriptional regulator
UP12_01020	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UP12_01055	COG1595	DNA-templated transcription, initiation
UP12_01060	COG5662	AntiSigma factor
UP12_01065	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UP12_01070	COG4856	YbbR-like protein
UP12_01075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP12_01080	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UP12_01130	COG1131	(ABC) transporter
UP12_01145	COG1131	(ABC) transporter
UP12_01160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_01170	COG2311	Membrane
UP12_01190	COG1476	TRANSCRIPTIONal
UP12_01200	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
UP12_01205	COG1309	transcriptional regulator
UP12_01220	COG1113	amino acid transport
UP12_01225	COG0584	glycerophosphoryl diester phosphodiesterase
UP12_01230	COG2271	Major facilitator Superfamily
UP12_01235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP12_01240	COG1331	Highly conserved protein containing a thioredoxin domain
UP12_01250	COG1309	transcriptional regulator
UP12_01255	COG0300	oxidoreductase activity
UP12_01265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP12_01280	COG1937	Protein conserved in bacteria
UP12_01285	COG2210	Belongs to the sulfur carrier protein TusA family
UP12_01295	COG0425	Belongs to the sulfur carrier protein TusA family
UP12_01295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP12_01300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP12_01300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP12_01305	COG0425	Belongs to the sulfur carrier protein TusA family
UP12_01310	COG0730	response to heat
UP12_01315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP12_01320	COG2814	Major facilitator Superfamily
UP12_01330	COG1846	Transcriptional regulator
UP12_01340	COG1683	Conserved Protein
UP12_01350	COG0656	L-ascorbic acid biosynthetic process
UP12_01355	COG0371	Dehydrogenase
UP12_01365	COG0531	amino acid
UP12_01375	COG3711	transcriptional antiterminator
UP12_01380	COG1263	PTS System
UP12_01380	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_01380	COG2190	(PTS) system
UP12_01385	COG2723	6-phospho-beta-galactosidase activity
UP12_01405	COG3711	transcriptional antiterminator
UP12_01405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_01410	COG1940	carbohydrate kinase activity
UP12_01415	COG0383	alpha-mannosidase activity
UP12_01420	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_01425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_01435	COG1404	Belongs to the peptidase S8 family
UP12_01450	COG0833	amino acid
UP12_01455	COG2040	homocysteine
UP12_01460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP12_01465	COG1695	Transcriptional regulator
UP12_01475	COG2814	Major facilitator Superfamily
UP12_01495	COG1404	Belongs to the peptidase S8 family
UP12_01505	COG1309	transcriptional regulator
UP12_01510	COG1917	Cupin 2, conserved barrel domain protein
UP12_01515	COG1063	alcohol dehydrogenase
UP12_01520	COG1846	Transcriptional regulator
UP12_01525	COG0318	PFAM AMP-dependent synthetase and ligase
UP12_01530	COG0531	amino acid
UP12_01540	COG0596	Alpha beta hydrolase
UP12_01545	COG1115	amino acid carrier protein
UP12_01550	COG2066	Belongs to the glutaminase family
UP12_01555	COG4191	Histidine kinase
UP12_01560	COG0784	Response regulator, receiver
UP12_01565	COG3012	SEC-C Motif Domain Protein
UP12_01565	COG1405	negative regulation of cell septum assembly
UP12_01575	COG0667	Aldo Keto reductase
UP12_01580	COG3290	protein histidine kinase activity
UP12_01585	COG3279	Response regulator of the LytR AlgR family
UP12_01590	COG4555	ABC transporter
UP12_01595	COG1668	transmembrane transport
UP12_01610	COG3773	Cell wall hydrolase
UP12_01615	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_01625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP12_01630	COG2310	stress, protein
UP12_01635	COG2310	stress, protein
UP12_01640	COG2310	stress, protein
UP12_01645	COG0861	Integral membrane protein TerC family
UP12_01675	COG3853	Toxic anion resistance protein (TelA)
UP12_01680	COG4175	Glycine betaine
UP12_01680	COG0517	IMP dehydrogenase activity
UP12_01685	COG4176	ABC-type proline glycine betaine transport system permease component
UP12_01690	COG2113	Glycine betaine
UP12_01705	COG1473	amidohydrolase
UP12_01710	COG1288	antiporter activity
UP12_01715	COG0039	L-malate dehydrogenase activity
UP12_01720	COG1620	l-lactate permease
UP12_01725	COG1609	Transcriptional regulator
UP12_01730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UP12_01735	COG0561	phosphatase activity
UP12_01740	COG0673	inositol 2-dehydrogenase activity
UP12_01745	COG0738	Major facilitator superfamily
UP12_01750	COG1280	lysine exporter protein (LysE YggA)
UP12_01760	COG3403	YqcI/YcgG family
UP12_01765	COG1113	amino acid transport
UP12_01770	COG3665	Urea carboxylase-associated protein
UP12_01775	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UP12_01795	COG0457	Tetratricopeptide repeat
UP12_01810	COG1012	belongs to the aldehyde dehydrogenase family
UP12_01815	COG0710	3-dehydroquinate dehydratase activity
UP12_01820	COG0028	Belongs to the TPP enzyme family
UP12_01830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UP12_01835	COG2271	Major facilitator Superfamily
UP12_01845	COG1414	Transcriptional regulator
UP12_01850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UP12_01855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP12_01865	COG0477	Major facilitator Superfamily
UP12_01870	COG2226	methyltransferase
UP12_01875	COG0583	DNA-binding transcription factor activity
UP12_01880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP12_01885	COG3458	cephalosporin-C deacetylase activity
UP12_01895	COG3541	Predicted nucleotidyltransferase
UP12_01900	COG0506	proline dehydrogenase activity
UP12_01905	COG1012	belongs to the aldehyde dehydrogenase family
UP12_01910	COG2508	Transcriptional regulator
UP12_01915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP12_01920	COG0765	amino acid transport
UP12_01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_01935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP12_01940	COG1522	sequence-specific DNA binding
UP12_01945	COG2746	aminoglycoside 3-N-acetyltransferase activity
UP12_01955	COG3290	protein histidine kinase activity
UP12_01955	COG0840	transmembrane signaling receptor activity
UP12_01960	COG3209	COG3209 Rhs family protein
UP12_01985	COG3842	ATPase activity
UP12_01990	COG1176	ABC-type spermidine putrescine transport system, permease component I
UP12_02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP12_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP12_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP12_02025	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
UP12_02030	COG0697	spore germination
UP12_02035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP12_02050	COG2364	Membrane
UP12_02060	COG3764	Sortase (surface protein transpeptidase)
UP12_02065	COG2002	toxin-antitoxin pair type II binding
UP12_02070	COG1126	abc transporter atp-binding protein
UP12_02075	COG0765	amino acid transport
UP12_02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_02085	COG0833	amino acid
UP12_02090	COG3104	oligopeptide transport
UP12_02095	COG5434	Belongs to the glycosyl hydrolase 28 family
UP12_02110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_02115	COG0765	amino acid transport
UP12_02120	COG1126	abc transporter atp-binding protein
UP12_02130	COG2079	MmgE PrpD family protein
UP12_02135	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_02140	COG0527	aspartate kinase activity
UP12_02145	COG2814	Major facilitator Superfamily
UP12_02150	COG1309	transcriptional regulator
UP12_02160	COG0640	Transcriptional regulator
UP12_02165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP12_02170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
UP12_02175	COG0531	amino acid
UP12_02180	COG1012	belongs to the aldehyde dehydrogenase family
UP12_02185	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP12_02190	COG4549	nuclear export factor GLE1
UP12_02195	COG1276	copper resistance
UP12_02195	COG2372	response to copper ion
UP12_02200	COG2213	PTS system mannitol-specific
UP12_02205	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_02210	COG0246	Mannitol dehydrogenase
UP12_02215	COG0840	transmembrane signaling receptor activity
UP12_02235	COG0346	lactoylglutathione lyase activity
UP12_02245	COG0561	phosphatase activity
UP12_02250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UP12_02255	COG1914	H( )-stimulated, divalent metal cation uptake system
UP12_02260	COG4336	lyase activity
UP12_02265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UP12_02270	COG1984	allophanate hydrolase subunit 2
UP12_02275	COG1414	Transcriptional regulator
UP12_02280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP12_02285	COG2755	lipolytic protein G-D-S-L family
UP12_02295	COG3711	transcriptional antiterminator
UP12_02300	COG2226	methyltransferase
UP12_02305	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_02310	COG3871	stress protein (general stress protein 26)
UP12_02330	COG2814	Major facilitator Superfamily
UP12_02335	COG1802	Transcriptional regulator
UP12_02340	COG2207	Transcriptional regulator
UP12_02340	COG1917	Cupin 2, conserved barrel domain protein
UP12_02345	COG0697	spore germination
UP12_02350	COG0473	3-isopropylmalate dehydrogenase activity
UP12_02355	COG0551	DNA topoisomerase type I activity
UP12_02355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP12_02360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
UP12_02365	COG3706	GGDEF domain
UP12_02370	COG5298	Protein conserved in bacteria
UP12_02375	COG1215	transferase activity, transferring glycosyl groups
UP12_02385	COG0531	amino acid
UP12_02390	COG0028	Belongs to the TPP enzyme family
UP12_02395	COG5444	nuclease activity
UP12_02415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP12_02420	COG1914	H( )-stimulated, divalent metal cation uptake system
UP12_02425	COG2261	transglycosylase associated protein
UP12_02430	COG2217	Heavy metal translocating P-type atpase
UP12_02435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UP12_02440	COG3290	protein histidine kinase activity
UP12_02445	COG4565	transcriptional regulatory protein
UP12_02450	COG1301	dicarboxylic acid transport
UP12_02455	COG0628	permease
UP12_02460	COG1301	dicarboxylic acid transport
UP12_02465	COG1131	(ABC) transporter
UP12_02470	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP12_02480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_02485	COG1181	Belongs to the D-alanine--D-alanine ligase family
UP12_02490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UP12_02505	COG0513	Belongs to the DEAD box helicase family
UP12_02510	COG3402	PFAM membrane-flanked domain
UP12_02515	COG3428	Bacterial PH domain
UP12_02520	COG0705	Rhomboid family
UP12_02525	COG0736	holo-[acyl-carrier-protein] synthase activity
UP12_02530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UP12_02535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UP12_02540	COG0864	Transcriptional regulator
UP12_02545	COG2337	Toxic component of a toxin-antitoxin (TA) module
UP12_02550	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_02555	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_02560	COG2172	sigma factor antagonist activity
UP12_02565	COG2208	phosphoserine phosphatase activity
UP12_02570	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_02575	COG2172	sigma factor antagonist activity
UP12_02580	COG1191	sigma factor activity
UP12_02585	COG2208	phosphoserine phosphatase activity
UP12_02590	COG2183	response to ionizing radiation
UP12_02595	COG3091	SprT-like family
UP12_02600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP12_02605	COG0022	dehydrogenase e1 component
UP12_02610	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP12_02615	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP12_02620	COG3284	Transcriptional regulator
UP12_02660	COG0582	viral genome integration into host DNA
UP12_02665	COG2856	Zn peptidase
UP12_02670	COG1396	sequence-specific DNA binding
UP12_02700	COG1674	ftsk spoiiie
UP12_02705	COG2946	Replication initiation factor
UP12_02785	COG0433	COG0433 Predicted ATPase
UP12_02790	COG5644	endopeptidase inhibitor activity
UP12_02795	COG0791	NLP P60 protein
UP12_02795	COG0741	lytic transglycosylase activity
UP12_02810	COG0457	Tetratricopeptide repeat
UP12_02820	COG0604	alcohol dehydrogenase
UP12_02845	COG1404	Belongs to the peptidase S8 family
UP12_02850	COG1278	Cold shock
UP12_02855	COG1329	Transcriptional regulator
UP12_02860	COG1064	alcohol dehydrogenase
UP12_02865	COG0789	Transcriptional regulator
UP12_02880	COG0477	Major facilitator Superfamily
UP12_02925	COG0252	asparaginase activity
UP12_02945	COG2814	Major facilitator Superfamily
UP12_02950	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
UP12_02955	COG2409	Drug exporters of the RND superfamily
UP12_02960	COG4585	Histidine kinase
UP12_02965	COG2197	response regulator
UP12_02995	COG1309	transcriptional regulator
UP12_03000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP12_03005	COG1846	Transcriptional regulator
UP12_03010	COG0778	Nitroreductase
UP12_03025	COG1396	sequence-specific DNA binding
UP12_03035	COG0456	acetyltransferase
UP12_03040	COG0583	DNA-binding transcription factor activity
UP12_03045	COG0667	Aldo Keto reductase
UP12_03055	COG4122	O-methyltransferase activity
UP12_03065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UP12_03070	COG0697	spore germination
UP12_03080	COG1301	dicarboxylic acid transport
UP12_03120	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
UP12_03125	COG0802	atpase or kinase
UP12_03130	COG1214	PFAM Peptidase M22, glycoprotease
UP12_03135	COG0456	acetyltransferase
UP12_03140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UP12_03145	COG0488	(ABC) transporter
UP12_03150	COG0315	cyclic pyranopterin monophosphate synthase activity
UP12_03155	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UP12_03160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP12_03165	COG0805	protein transport
UP12_03170	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
UP12_03180	COG1266	CAAX protease self-immunity
UP12_03185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UP12_03190	COG0459	protein refolding
UP12_03195	COG1846	Transcriptional regulator
UP12_03200	COG0456	acetyltransferase
UP12_03205	COG2808	Putative FMN-binding domain
UP12_03225	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UP12_03230	COG0823	Involved in the tonB-independent uptake of proteins
UP12_03240	COG2132	Multicopper oxidase
UP12_03245	COG1113	amino acid transport
UP12_03250	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP12_03255	COG0714	Associated with various cellular activities
UP12_03260	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
UP12_03265	COG1305	Transglutaminase-like
UP12_03270	COG0519	Catalyzes the synthesis of GMP from XMP
UP12_03270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UP12_03290	COG3279	Response regulator of the LytR AlgR family
UP12_03305	COG2814	Major facilitator Superfamily
UP12_03310	COG0583	DNA-binding transcription factor activity
UP12_03315	COG2252	PERMEase
UP12_03320	COG3064	Membrane
UP12_03325	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
UP12_03335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UP12_03340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UP12_03345	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UP12_03350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UP12_03355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UP12_03360	COG0047	phosphoribosylformylglycinamidine synthase activity
UP12_03365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UP12_03370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UP12_03375	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UP12_03380	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UP12_03385	COG0138	bifunctional purine biosynthesis protein purh
UP12_03390	COG0151	Belongs to the GarS family
UP12_03410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP12_03415	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP12_03420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP12_03425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP12_03435	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UP12_03440	COG4496	protein, YerC YecD
UP12_03450	COG0069	glutamate synthase activity
UP12_03465	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
UP12_03470	COG0210	DNA helicase
UP12_03475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UP12_03480	COG4851	CamS sex pheromone cAM373 precursor
UP12_03495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UP12_03510	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP12_03525	COG1960	acyl-CoA dehydrogenase activity
UP12_03535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP12_03545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP12_03545	COG0300	oxidoreductase activity
UP12_03545	COG3321	synthase
UP12_03545	COG4221	oxidoreductase activity
UP12_03555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP12_03560	COG1785	Belongs to the alkaline phosphatase family
UP12_03565	COG1285	pathogenesis
UP12_03570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP12_03575	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP12_03580	COG0154	amidase activity
UP12_03585	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP12_03590	COG1309	transcriptional regulator
UP12_03595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP12_03600	COG1957	nucleoside hydrolase
UP12_03605	COG1597	lipid kinase activity
UP12_03610	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UP12_03630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP12_03640	COG1737	Transcriptional regulator
UP12_03645	COG1263	PTS System
UP12_03645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_03650	COG1486	melibiose metabolic process
UP12_03660	COG1959	2 iron, 2 sulfur cluster binding
UP12_03665	COG0492	ferredoxin-NADP+ reductase activity
UP12_03680	COG1486	melibiose metabolic process
UP12_03690	COG2211	Major facilitator Superfamily
UP12_03715	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
UP12_03720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP12_03725	COG1442	glycosyl transferase family 8
UP12_03730	COG1216	Glycosyl transferase, family 2
UP12_03735	COG1442	glycosyl transferase family 8
UP12_03740	COG2223	nitrite transmembrane transporter activity
UP12_03750	COG0471	metal ion transport
UP12_03765	COG0071	Belongs to the small heat shock protein (HSP20) family
UP12_03780	COG0531	amino acid
UP12_03785	COG0463	Glycosyl transferase, family 2
UP12_03785	COG0457	Tetratricopeptide repeat
UP12_03790	COG0488	(ABC) transporter
UP12_03795	COG0789	Transcriptional regulator
UP12_03800	COG2814	Major facilitator Superfamily
UP12_03805	COG0488	(ABC) transporter
UP12_03810	COG0513	Belongs to the DEAD box helicase family
UP12_03815	COG2130	NADP-dependent
UP12_03835	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP12_03835	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP12_03840	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UP12_03850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP12_03850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP12_03860	COG3290	protein histidine kinase activity
UP12_03865	COG4565	transcriptional regulatory protein
UP12_03870	COG3181	Tripartite tricarboxylate transporter family receptor
UP12_03875	COG2851	Citrate transporter
UP12_03885	COG3479	Phenolic acid decarboxylase
UP12_03890	COG1695	Transcriptional regulator
UP12_03895	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
UP12_03900	COG1254	Belongs to the acylphosphatase family
UP12_03905	COG2258	MOSC domain
UP12_03910	COG0024	Methionine aminopeptidase
UP12_03915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_03915	COG1263	PTS System
UP12_03920	COG3739	integral membrane protein
UP12_03935	COG1368	sulfuric ester hydrolase activity
UP12_03940	COG0076	glutamate decarboxylase activity
UP12_03955	COG1263	PTS System
UP12_03955	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_03960	COG0366	Alpha amylase catalytic
UP12_03965	COG2188	Transcriptional regulator
UP12_03975	COG0737	Belongs to the 5'-nucleotidase family
UP12_03980	COG0693	protein deglycase activity
UP12_03985	COG4840	Belongs to the UPF0435 family
UP12_03990	COG1115	amino acid carrier protein
UP12_03995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP12_04000	COG4980	gas vesicle protein
UP12_04005	COG1295	ribonuclease BN
UP12_04010	COG0477	Major facilitator Superfamily
UP12_04020	COG0387	Pfam Sodium calcium exchanger
UP12_04030	COG0217	transcriptional regulatory protein
UP12_04040	COG0668	transmembrane transport
UP12_04045	COG0535	radical SAM domain protein
UP12_04055	COG0726	polysaccharide deacetylase
UP12_04065	COG0598	Magnesium transport protein CorA
UP12_04075	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UP12_04080	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UP12_04105	COG0789	Transcriptional regulator
UP12_04110	COG2814	Major facilitator Superfamily
UP12_04125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP12_04165	COG2076	Multidrug Resistance protein
UP12_04170	COG2076	Multidrug Resistance protein
UP12_04175	COG1309	transcriptional regulator
UP12_04185	COG4637	Psort location Cytoplasmic, score
UP12_04190	COG2755	lipolytic protein G-D-S-L family
UP12_04195	COG0492	ferredoxin-NADP+ reductase activity
UP12_04200	COG2207	Transcriptional regulator
UP12_04200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_04205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_04210	COG1132	(ABC) transporter
UP12_04215	COG1742	UPF0060 membrane protein
UP12_04220	COG1595	DNA-templated transcription, initiation
UP12_04240	COG2318	DinB family
UP12_04250	COG1846	Transcriptional regulator
UP12_04255	COG0392	lysyltransferase activity
UP12_04255	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
UP12_04280	COG0778	Nitroreductase
UP12_04290	COG1090	epimerase
UP12_04295	COG2137	regulation of response to DNA damage stimulus
UP12_04315	COG0463	Glycosyl transferase, family 2
UP12_04320	COG4485	Bacterial membrane protein, YfhO
UP12_04325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UP12_04340	COG2140	Oxalate decarboxylase
UP12_04345	COG1191	sigma factor activity
UP12_04355	COG1988	membrane-bound metal-dependent
UP12_04360	COG1194	a g-specific adenine glycosylase
UP12_04370	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_04385	COG3557	Belongs to the UPF0374 family
UP12_04390	COG1132	(ABC) transporter
UP12_04395	COG0444	Belongs to the ABC transporter superfamily
UP12_04400	COG4608	Belongs to the ABC transporter superfamily
UP12_04405	COG0747	negative chemotaxis
UP12_04420	COG4129	membrane
UP12_04425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP12_04430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UP12_04435	COG0735	belongs to the Fur family
UP12_04590	COG1368	sulfuric ester hydrolase activity
UP12_04595	COG0681	Belongs to the peptidase S26 family
UP12_04610	COG1131	(ABC) transporter
UP12_04640	COG3382	B3 4 domain protein
UP12_04645	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UP12_04655	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UP12_04665	COG2766	serine protein kinase
UP12_04670	COG2718	Belongs to the UPF0229 family
UP12_04675	COG1566	PFAM secretion protein HlyD family protein
UP12_04680	COG2814	Major facilitator Superfamily
UP12_04685	COG0655	NAD(P)H dehydrogenase (quinone) activity
UP12_04695	COG1278	Cold shock
UP12_04700	COG3706	GGDEF domain
UP12_04725	COG5577	PFAM Coat F domain
UP12_04730	COG5002	protein histidine kinase activity
UP12_04735	COG1525	nuclease
UP12_04735	COG0737	Belongs to the 5'-nucleotidase family
UP12_04735	COG4085	toxin activity
UP12_04740	COG3764	Sortase (surface protein transpeptidase)
UP12_04745	COG0564	pseudouridine synthase activity
UP12_04755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UP12_04760	COG3153	acetyltransferase
UP12_04760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP12_04775	COG3835	regulator
UP12_04780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP12_04785	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
UP12_04790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UP12_04795	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
UP12_04800	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UP12_04805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP12_04810	COG2203	Gaf domain
UP12_04810	COG4585	Histidine kinase
UP12_04815	COG2197	response regulator
UP12_04835	COG0753	catalase activity
UP12_04840	COG1959	2 iron, 2 sulfur cluster binding
UP12_04845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UP12_04845	COG1017	nitric oxide dioxygenase activity
UP12_04850	COG2719	SpoVR family
UP12_04855	COG1785	Belongs to the alkaline phosphatase family
UP12_04860	COG0791	NLP P60 protein
UP12_04860	COG1388	LysM domain
UP12_04875	COG1595	DNA-templated transcription, initiation
UP12_04880	COG0204	Acyl-transferase
UP12_04885	COG1253	flavin adenine dinucleotide binding
UP12_04890	COG0789	Transcriptional regulator
UP12_04895	COG1253	flavin adenine dinucleotide binding
UP12_04910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UP12_04930	COG0726	polysaccharide deacetylase
UP12_04935	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP12_04940	COG0589	response to stress
UP12_04945	COG1132	(ABC) transporter
UP12_04950	COG1132	(ABC) transporter
UP12_04955	COG0702	epimerase
UP12_04965	COG3842	ATPase activity
UP12_04970	COG2508	Transcriptional regulator
UP12_04980	COG0189	ligase activity
UP12_04985	COG0189	ligase activity
UP12_04990	COG4399	Belongs to the UPF0754 family
UP12_04995	COG3679	Belongs to the UPF0342 family
UP12_05000	COG0561	phosphatase activity
UP12_05005	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP12_05015	COG0475	glutathione-regulated potassium exporter activity
UP12_05020	COG0490	domain, Protein
UP12_05030	COG1024	Enoyl-CoA hydratase
UP12_05040	COG0420	3'-5' exonuclease activity
UP12_05045	COG4717	serine-type aminopeptidase activity
UP12_05050	COG3481	metal-dependent phosphohydrolase, HD sub domain
UP12_05060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP12_05085	COG1846	Transcriptional regulator
UP12_05090	COG4980	gas vesicle protein
UP12_05105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UP12_05110	COG0537	adenosine 5'-monophosphoramidase activity
UP12_05115	COG1131	(ABC) transporter
UP12_05120	COG4473	ABC transporter
UP12_05130	COG1473	amidohydrolase
UP12_05140	COG2329	Antibiotic biosynthesis monooxygenase
UP12_05145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP12_05150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UP12_05165	COG1309	transcriptional regulator
UP12_05170	COG1511	domain protein
UP12_05175	COG1363	Peptidase, m42
UP12_05180	COG1301	dicarboxylic acid transport
UP12_05185	COG1234	tRNA 3'-trailer cleavage
UP12_05190	COG0095	Lipoate-protein ligase
UP12_05195	COG0318	PFAM AMP-dependent synthetase and ligase
UP12_05205	COG0501	Belongs to the peptidase M48B family
UP12_05210	COG1404	Belongs to the peptidase S8 family
UP12_05215	COG0406	alpha-ribazole phosphatase activity
UP12_05220	COG0840	transmembrane signaling receptor activity
UP12_05225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP12_05225	COG0723	plastoquinol--plastocyanin reductase activity
UP12_05230	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_05240	COG4903	ComK protein
UP12_05255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP12_05260	COG2814	Major facilitator Superfamily
UP12_05265	COG2732	(Barnase) inhibitor
UP12_05270	COG1316	TRANSCRIPTIONal
UP12_05280	COG0398	Pfam SNARE associated Golgi protein
UP12_05285	COG0681	Belongs to the peptidase S26 family
UP12_05290	COG3180	Ammonia monooxygenase
UP12_05300	COG0501	Belongs to the peptidase M48B family
UP12_05305	COG2259	Doxx family
UP12_05310	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
UP12_05315	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
UP12_05320	COG1074	ATP-dependent DNA helicase activity
UP12_05325	COG0420	3'-5' exonuclease activity
UP12_05330	COG0419	ATPase involved in DNA repair
UP12_05335	COG1403	HNH endonuclease
UP12_05375	COG5337	Spore coat protein CotH
UP12_05385	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP12_05400	COG0367	asparagine synthase
UP12_05415	COG1562	ergosterol biosynthetic process
UP12_05420	COG0534	Mate efflux family protein
UP12_05425	COG1917	Cupin 2, conserved barrel domain protein
UP12_05425	COG2207	Transcriptional regulator
UP12_05455	COG0076	glutamate decarboxylase activity
UP12_05485	COG1410	methionine synthase
UP12_05485	COG0646	methionine synthase
UP12_05490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UP12_05490	COG0646	methionine synthase
UP12_05495	COG1666	GTP binding
UP12_05500	COG2996	Protein conserved in bacteria
UP12_05510	COG0840	transmembrane signaling receptor activity
UP12_05515	COG1307	EDD domain protein, DegV family
UP12_05520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP12_05540	COG0561	phosphatase activity
UP12_05545	COG1073	alpha beta
UP12_05550	COG2151	metal-sulfur cluster biosynthetic enzyme
UP12_05555	COG0277	FAD linked oxidase domain protein
UP12_05560	COG2271	Major facilitator Superfamily
UP12_05565	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UP12_05575	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UP12_05580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UP12_05585	COG0505	Belongs to the CarA family
UP12_05590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UP12_05595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UP12_05605	COG2814	Major facilitator Superfamily
UP12_05615	COG2267	carboxylic ester hydrolase activity
UP12_05625	COG1744	ABC transporter substrate-binding protein PnrA-like
UP12_05640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP12_05645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP12_05650	COG5504	Zn-dependent protease
UP12_05655	COG0444	Belongs to the ABC transporter superfamily
UP12_05660	COG4608	Belongs to the ABC transporter superfamily
UP12_05670	COG0601	transmembrane transport
UP12_05675	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP12_05685	COG0180	Tryptophanyl-tRNA synthetase
UP12_05690	COG4166	transmembrane transport
UP12_05695	COG0601	transmembrane transport
UP12_05700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP12_05705	COG0444	Belongs to the ABC transporter superfamily
UP12_05710	COG4608	Belongs to the ABC transporter superfamily
UP12_05720	COG0456	acetyltransferase
UP12_05725	COG1393	Belongs to the ArsC family
UP12_05730	COG0861	Integral membrane protein TerC family
UP12_05735	COG4862	establishment of competence for transformation
UP12_05740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP12_05750	COG1164	Oligoendopeptidase f
UP12_05765	COG2346	COG2346, Truncated hemoglobins
UP12_05770	COG0741	lytic transglycosylase activity
UP12_05775	COG4116	CYTH
UP12_05785	COG2357	RelA SpoT domain protein
UP12_05790	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP12_05795	COG0564	pseudouridine synthase activity
UP12_05800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UP12_05805	COG0569	domain protein
UP12_05805	COG0475	glutathione-regulated potassium exporter activity
UP12_05810	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP12_05815	COG0352	thiamine-phosphate diphosphorylase activity
UP12_05825	COG2104	thiamine diphosphate biosynthetic process
UP12_05830	COG2022	thiamine diphosphate biosynthetic process
UP12_05835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP12_05840	COG0351	phosphomethylpyrimidine kinase
UP12_05845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UP12_05900	COG0210	DNA helicase
UP12_05910	COG2153	protein acetylation
UP12_05915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UP12_05920	COG2382	esterase
UP12_05925	COG0626	cystathionine gamma-synthase activity
UP12_05930	COG0626	cystathionine gamma-synthase activity
UP12_05940	COG0604	alcohol dehydrogenase
UP12_05950	COG0825	malonyl-CoA metabolic process
UP12_05960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP12_05970	COG2807	transmembrane transport
UP12_05980	COG0583	DNA-binding transcription factor activity
UP12_05995	COG0457	Tetratricopeptide repeat
UP12_06020	COG3173	Aminoglycoside phosphotransferase
UP12_06025	COG0583	DNA-binding transcription factor activity
UP12_06040	COG0583	DNA-binding transcription factor activity
UP12_06045	COG2807	transmembrane transport
UP12_06070	COG0457	Tetratricopeptide repeat
UP12_06090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UP12_06110	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP12_06115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP12_06120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP12_06125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP12_06145	COG4195	phage-related replication protein
UP12_06150	COG2856	Zn peptidase
UP12_06155	COG3409	Peptidoglycan-binding domain 1 protein
UP12_06155	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP12_06170	COG0306	phosphate transporter
UP12_06175	COG1392	Phosphate transport regulator
UP12_06185	COG0405	Gamma-glutamyltransferase
UP12_06195	COG3775	system Galactitol-specific IIC component
UP12_06210	COG1063	alcohol dehydrogenase
UP12_06215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP12_06220	COG0022	dehydrogenase e1 component
UP12_06220	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP12_06225	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP12_06230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP12_06235	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_06240	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_06245	COG2390	Transcriptional regulator
UP12_06255	COG0531	amino acid
UP12_06260	COG0346	lactoylglutathione lyase activity
UP12_06265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP12_06270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP12_06275	COG2362	D-Aminopeptidase
UP12_06280	COG0601	transmembrane transport
UP12_06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP12_06290	COG0444	Belongs to the ABC transporter superfamily
UP12_06295	COG4166	transmembrane transport
UP12_06300	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP12_06305	COG4948	Mandelate Racemase Muconate Lactonizing
UP12_06310	COG0791	NLP P60 protein
UP12_06315	COG4608	Belongs to the ABC transporter superfamily
UP12_06320	COG1834	amidinotransferase
UP12_06325	COG1607	acyl-coa hydrolase
UP12_06345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP12_06355	COG2076	Multidrug Resistance protein
UP12_06360	COG2076	Multidrug Resistance protein
UP12_06370	COG0788	formyltetrahydrofolate deformylase activity
UP12_06375	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP12_06380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP12_06385	COG0457	Tetratricopeptide repeat
UP12_06395	COG1764	response to oxidative stress
UP12_06400	COG1846	Transcriptional regulator
UP12_06405	COG1764	response to oxidative stress
UP12_06410	COG0590	tRNA wobble adenosine to inosine editing
UP12_06415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UP12_06420	COG1404	Belongs to the peptidase S8 family
UP12_06425	COG0745	RESPONSE REGULATOR receiver
UP12_06430	COG5002	protein histidine kinase activity
UP12_06430	COG3850	Histidine kinase
UP12_06435	COG3212	peptidase
UP12_06440	COG3212	peptidase
UP12_06450	COG2239	Acts as a magnesium transporter
UP12_06460	COG0583	DNA-binding transcription factor activity
UP12_06470	COG0789	Transcriptional regulator
UP12_06480	COG1846	Transcriptional regulator
UP12_06485	COG5001	Diguanylate cyclase
UP12_06485	COG3300	MHYT domain
UP12_06490	COG0586	Pfam SNARE associated Golgi protein
UP12_06495	COG0861	Integral membrane protein TerC family
UP12_06500	COG1191	sigma factor activity
UP12_06520	COG0501	Belongs to the peptidase M48B family
UP12_06525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP12_06530	COG2323	membrane
UP12_06540	COG3594	Acyltransferase
UP12_06545	COG5002	protein histidine kinase activity
UP12_06550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UP12_06555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UP12_06560	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
UP12_06565	COG0436	Aminotransferase
UP12_06570	COG1850	ribulose-bisphosphate carboxylase activity
UP12_06575	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
UP12_06580	COG0235	Class ii aldolase
UP12_06585	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
UP12_06595	COG3852	Histidine kinase
UP12_06600	COG1846	Transcriptional regulator
UP12_06605	COG1360	Flagellar Motor Protein
UP12_06610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UP12_06615	COG0542	response to heat
UP12_06620	COG3949	Membrane
UP12_06625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UP12_06630	COG0720	synthase
UP12_06635	COG0602	queuosine metabolic process
UP12_06640	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UP12_06655	COG4873	Protein conserved in bacteria
UP12_06665	COG3773	Cell wall hydrolase
UP12_06670	COG2244	polysaccharide biosynthetic process
UP12_06675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_06680	COG2217	Heavy metal translocating P-type atpase
UP12_06685	COG0006	proline dipeptidase activity
UP12_06690	COG1609	Transcriptional regulator
UP12_06695	COG3711	transcriptional antiterminator
UP12_06700	COG2190	(PTS) system
UP12_06700	COG1263	PTS System
UP12_06700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_06705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_06710	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UP12_06720	COG1533	DNA photolyase activity
UP12_06725	COG0840	transmembrane signaling receptor activity
UP12_06735	COG2084	Dehydrogenase
UP12_06740	COG2340	Cysteine-rich secretory protein family
UP12_06745	COG0768	penicillin binding
UP12_06750	COG4191	Histidine kinase
UP12_06755	COG0436	Aminotransferase
UP12_06760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP12_06765	COG1714	RDD family
UP12_06775	COG0835	chemotaxis
UP12_06775	COG0784	Response regulator, receiver
UP12_06795	COG2814	Major facilitator Superfamily
UP12_06800	COG1376	ErfK ybiS ycfS ynhG family protein
UP12_06805	COG1408	metallophosphoesterase
UP12_06810	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_06815	COG2200	EAL domain
UP12_06820	COG3546	catalase activity
UP12_06825	COG4703	Protein of unknown function (DUF1797)
UP12_06830	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
UP12_06840	COG0517	IMP dehydrogenase activity
UP12_06845	COG0583	DNA-binding transcription factor activity
UP12_06855	COG0716	FMN binding
UP12_06865	COG0716	FMN binding
UP12_06870	COG2171	N-acyltransferase activity
UP12_06875	COG1473	amidohydrolase
UP12_06885	COG0668	transmembrane transport
UP12_06890	COG0450	alkyl hydroperoxide reductase
UP12_06895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_06910	COG0746	molybdenum cofactor guanylyltransferase activity
UP12_06915	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP12_06920	COG0303	'Molybdopterin
UP12_06925	COG1763	Mo-molybdopterin cofactor biosynthetic process
UP12_06930	COG0314	molybdopterin synthase activity
UP12_06935	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
UP12_06950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UP12_06955	COG1136	(ABC) transporter
UP12_06960	COG0577	efflux transmembrane transporter activity
UP12_06965	COG1349	DNA-binding transcription factor activity
UP12_06970	COG1105	Belongs to the carbohydrate kinase PfkB family
UP12_06975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_06975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_06975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_06980	COG0681	Belongs to the peptidase S26 family
UP12_06990	COG0488	(ABC) transporter
UP12_06995	COG2309	aminopeptidase activity
UP12_07000	COG1077	Cell shape determining protein MreB Mrl
UP12_07005	COG2002	toxin-antitoxin pair type II binding
UP12_07010	COG3852	Histidine kinase
UP12_07015	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
UP12_07015	COG2105	PFAM AIG2 family protein
UP12_07020	COG0569	domain protein
UP12_07025	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
UP12_07030	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP12_07040	COG0561	phosphatase activity
UP12_07045	COG0242	peptide deformylase activity
UP12_07060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP12_07065	COG0022	dehydrogenase e1 component
UP12_07070	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP12_07075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP12_07080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_07090	COG1982	Orn Lys Arg decarboxylase major
UP12_07095	COG4476	Belongs to the UPF0223 family
UP12_07100	COG4493	Belongs to the UPF0637 family
UP12_07110	COG0483	inositol monophosphate 1-phosphatase activity
UP12_07125	COG1595	DNA-templated transcription, initiation
UP12_07155	COG4896	Protein conserved in bacteria
UP12_07165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UP12_07170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UP12_07175	COG2066	Belongs to the glutaminase family
UP12_07180	COG4838	Belongs to the UPF0358 family
UP12_07185	COG0772	Belongs to the SEDS family
UP12_07190	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UP12_07200	COG1612	heme a metabolic process
UP12_07205	COG0109	protoheme IX farnesyltransferase activity
UP12_07210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UP12_07210	COG2010	Cytochrome c
UP12_07215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UP12_07220	COG1845	cytochrome c oxidase, subunit III
UP12_07225	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UP12_07230	COG3336	cytochrome c oxidase
UP12_07240	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
UP12_07245	COG2340	Cysteine-rich secretory protein family
UP12_07265	COG3679	Belongs to the UPF0342 family
UP12_07270	COG4471	UPF0298 protein
UP12_07275	COG0742	ribosomal rna small subunit methyltransferase
UP12_07280	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UP12_07285	COG3314	Sporulation integral membrane protein YlbJ
UP12_07290	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP12_07295	COG3480	Lon protease (S16) C-terminal proteolytic domain
UP12_07305	COG1399	metal-binding, possibly nucleic acid-binding protein
UP12_07310	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UP12_07320	COG0454	-acetyltransferase
UP12_07325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UP12_07330	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
UP12_07335	COG2001	Belongs to the MraZ family
UP12_07340	COG0275	rRNA processing
UP12_07345	COG4839	cell division protein FtsL
UP12_07355	COG0768	penicillin binding
UP12_07360	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UP12_07365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP12_07370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UP12_07375	COG0772	Belongs to the SEDS family
UP12_07380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UP12_07385	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UP12_07390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UP12_07395	COG3879	Bacterial protein of unknown function (DUF881)
UP12_07400	COG3879	Bacterial protein of unknown function (DUF881)
UP12_07405	COG3856	small basic protein
UP12_07410	COG0849	cell division
UP12_07415	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UP12_07420	COG1404	Belongs to the peptidase S8 family
UP12_07420	COG4412	M6 family metalloprotease domain protein
UP12_07430	COG1191	sigma factor activity
UP12_07435	COG1191	sigma factor activity
UP12_07440	COG2390	Transcriptional regulator
UP12_07455	COG3730	PTS system glucitol sorbitol-specific
UP12_07460	COG3732	PTS system glucitol sorbitol-specific
UP12_07470	COG1119	ATPase activity
UP12_07475	COG1873	PFAM PRC-barrel domain
UP12_07485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UP12_07490	COG1799	cell septum assembly
UP12_07495	COG0762	integral membrane protein
UP12_07500	COG2302	S4 RNA-binding domain
UP12_07505	COG3599	regulation of cell shape
UP12_07510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UP12_07515	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP12_07520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UP12_07525	COG0564	pseudouridine synthase activity
UP12_07530	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UP12_07535	COG2233	PERMEase
UP12_07540	COG0540	Belongs to the ATCase OTCase family
UP12_07545	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UP12_07550	COG0505	Belongs to the CarA family
UP12_07555	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UP12_07560	COG0543	2 iron, 2 sulfur cluster binding
UP12_07565	COG0167	dihydroorotate dehydrogenase activity
UP12_07570	COG0284	orotidine-5'-phosphate decarboxylase activity
UP12_07575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UP12_07580	COG0175	sulfate reduction
UP12_07585	COG0306	phosphate transporter
UP12_07590	COG2046	Belongs to the sulfate adenylyltransferase family
UP12_07595	COG0529	Catalyzes the synthesis of activated sulfate
UP12_07600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UP12_07605	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
UP12_07610	COG1648	precorrin-2 dehydrogenase activity
UP12_07620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UP12_07625	COG1561	YicC-like family, N-terminal region
UP12_07630	COG2052	Domain of unknown function (DUF370)
UP12_07635	COG0194	GDP metabolic process
UP12_07640	COG1758	RNA polymerase activity
UP12_07645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP12_07650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UP12_07655	COG0242	peptide deformylase activity
UP12_07660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UP12_07665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP12_07665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UP12_07670	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UP12_07675	COG0631	protein serine/threonine phosphatase activity
UP12_07680	COG0515	serine threonine protein kinase
UP12_07680	COG2815	serine threonine protein kinase
UP12_07685	COG1162	GTPase activity
UP12_07690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UP12_07695	COG1564	THIamine pyrophosphokinase
UP12_07705	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UP12_07710	COG1302	Protein conserved in bacteria
UP12_07715	COG1461	Dihydroxyacetone kinase
UP12_07720	COG1760	l-serine dehydratase
UP12_07725	COG1760	l-serine dehydratase
UP12_07730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UP12_07735	COG1349	DNA-binding transcription factor activity
UP12_07740	COG0416	fatty acid biosynthetic process
UP12_07745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UP12_07750	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_07755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP12_07765	COG1196	nuclear chromosome segregation
UP12_07770	COG0552	protein localization to endoplasmic reticulum
UP12_07775	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
UP12_07780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UP12_07785	COG0228	four-way junction DNA binding
UP12_07790	COG1837	Belongs to the UPF0109 family
UP12_07800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UP12_07805	COG0336	Belongs to the RNA methyltransferase TrmD family
UP12_07810	COG0335	large ribosomal subunit rRNA binding
UP12_07815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP12_07820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP12_07830	COG2257	FlhB HrpN YscU SpaS Family
UP12_07835	COG0045	succinate-CoA ligase (ADP-forming) activity
UP12_07840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UP12_07845	COG0758	DNA mediated transformation
UP12_07850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP12_07855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
UP12_07860	COG4974	Belongs to the 'phage' integrase family
UP12_07865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
UP12_07870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UP12_07875	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP12_07880	COG1815	bacterial-type flagellum-dependent cell motility
UP12_07885	COG1558	bacterial-type flagellum-dependent cell motility
UP12_07890	COG1677	Flagellar hook-basal body complex protein FliE
UP12_07895	COG1766	The M ring may be actively involved in energy transduction
UP12_07900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP12_07905	COG1317	bacterial-type flagellum organization
UP12_07910	COG1157	protein secretion by the type III secretion system
UP12_07915	COG2882	bacterial-type flagellum organization
UP12_07925	COG3144	bacterial-type flagellum assembly
UP12_07930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UP12_07935	COG4786	Flagellar basal body rod
UP12_07940	COG1582	Flagellar protein (FlbD)
UP12_07945	COG1580	Controls the rotational direction of flagella during chemotaxis
UP12_07950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP12_07955	COG1776	CheC inhibitor of MCP methylation
UP12_07955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP12_07960	COG2201	protein-glutamate methylesterase activity
UP12_07965	COG3190	flagellar
UP12_07970	COG1338	Plays a role in the flagellum-specific transport system
UP12_07975	COG1987	bacterial-type flagellum assembly
UP12_07980	COG1684	flagellar biosynthetic protein fliR
UP12_07985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP12_07990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP12_07995	COG1419	protein localization to endoplasmic reticulum
UP12_08000	COG0455	bacterial-type flagellum organization
UP12_08005	COG2201	protein-glutamate methylesterase activity
UP12_08010	COG2198	Histidine kinase
UP12_08010	COG0643	Histidine kinase
UP12_08015	COG0835	chemotaxis
UP12_08020	COG1776	CheC inhibitor of MCP methylation
UP12_08030	COG1191	sigma factor activity
UP12_08040	COG0052	Belongs to the universal ribosomal protein uS2 family
UP12_08045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UP12_08050	COG0528	UMP kinase activity
UP12_08055	COG0233	cytoplasmic translational termination
UP12_08060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
UP12_08065	COG4589	Belongs to the CDS family
UP12_08070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UP12_08075	COG0750	zinc metalloprotease
UP12_08080	COG0442	prolyl-tRNA aminoacylation
UP12_08085	COG2176	DNA-directed DNA polymerase activity
UP12_08110	COG0779	Required for maturation of 30S ribosomal subunits
UP12_08115	COG0195	Participates in both transcription termination and antitermination
UP12_08120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
UP12_08125	COG1358	cellular component organization or biogenesis
UP12_08130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UP12_08135	COG1550	Protein conserved in bacteria
UP12_08140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UP12_08145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UP12_08150	COG0196	riboflavin kinase activity
UP12_08155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UP12_08160	COG1185	polyribonucleotide nucleotidyltransferase activity
UP12_08165	COG0726	polysaccharide deacetylase
UP12_08170	COG0612	Peptidase, M16
UP12_08180	COG1873	PFAM PRC-barrel domain
UP12_08185	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP12_08190	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP12_08195	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UP12_08200	COG0527	aspartate kinase activity
UP12_08210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP12_08215	COG0740	serine-type endopeptidase activity
UP12_08225	COG4980	gas vesicle protein
UP12_08225	COG1674	ftsk spoiiie
UP12_08230	COG2188	Transcriptional regulator
UP12_08235	COG2814	Major facilitator Superfamily
UP12_08240	COG2409	Drug exporters of the RND superfamily
UP12_08240	COG1033	growth of symbiont in host cell
UP12_08245	COG0612	Peptidase, M16
UP12_08250	COG0612	Peptidase, M16
UP12_08260	COG2409	Drug exporters of the RND superfamily
UP12_08260	COG1033	growth of symbiont in host cell
UP12_08265	COG0300	oxidoreductase activity
UP12_08280	COG1426	Protein conserved in bacteria
UP12_08285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UP12_08290	COG1546	Belongs to the CinA family
UP12_08290	COG1058	Belongs to the CinA family
UP12_08295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UP12_08300	COG1418	mRNA catabolic process
UP12_08305	COG1692	metallophosphoesterase
UP12_08315	COG2359	stage V sporulation protein S
UP12_08320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP12_08325	COG1063	alcohol dehydrogenase
UP12_08330	COG0156	8-amino-7-oxononanoate synthase activity
UP12_08340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP12_08345	COG4550	Control of competence regulator ComK, YlbF/YmcA
UP12_08355	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
UP12_08360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UP12_08380	COG1329	Transcriptional regulator
UP12_08385	COG4195	phage-related replication protein
UP12_08390	COG0457	Tetratricopeptide repeat
UP12_08395	COG1404	Belongs to the peptidase S8 family
UP12_08400	COG4195	phage-related replication protein
UP12_08405	COG1764	response to oxidative stress
UP12_08410	COG2076	Multidrug Resistance protein
UP12_08435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
UP12_08440	COG1923	regulation of RNA biosynthetic process
UP12_08455	COG1780	Probably involved in ribonucleotide reductase function
UP12_08460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP12_08465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP12_08470	COG4112	unkown
UP12_08480	COG0464	growth
UP12_08485	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UP12_08490	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
UP12_08495	COG0789	Transcriptional regulator
UP12_08500	COG0174	glutamine synthetase
UP12_08520	COG5444	nuclease activity
UP12_08555	COG5646	InterPro IPR014922
UP12_08565	COG0457	Tetratricopeptide repeat
UP12_08575	COG3619	membrane
UP12_08580	COG3285	dna ligase
UP12_08580	COG1793	dna ligase
UP12_08585	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
UP12_08590	COG4876	unkown
UP12_08600	COG1959	2 iron, 2 sulfur cluster binding
UP12_08605	COG0702	epimerase
UP12_08610	COG0247	lactate metabolic process
UP12_08615	COG1139	Iron-sulfur cluster binding protein
UP12_08620	COG1556	Lactate utilization protein
UP12_08640	COG2323	membrane
UP12_08645	COG1309	transcriptional regulator
UP12_08650	COG2124	cytochrome p450
UP12_08650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UP12_08655	COG3591	Belongs to the peptidase S1B family
UP12_08660	COG3209	COG3209 Rhs family protein
UP12_08665	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_08680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UP12_08685	COG1388	LysM domain
UP12_08690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UP12_08695	COG4224	UPF0291 protein
UP12_08700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UP12_08710	COG3763	UPF0154 protein
UP12_08720	COG0785	Cytochrome C biogenesis protein
UP12_08725	COG4846	Membrane protein involved in cytochrome C biogenesis
UP12_08735	COG0071	Belongs to the small heat shock protein (HSP20) family
UP12_08750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UP12_08755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_08770	COG0824	Thioesterase
UP12_08780	COG4841	protein insertion into membrane
UP12_08785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UP12_08790	COG1832	CoA-binding protein
UP12_08800	COG0187	DNA topoisomerase II activity
UP12_08805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP12_08815	COG0738	Major facilitator superfamily
UP12_08825	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP12_08830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP12_08835	COG0640	Transcriptional regulator
UP12_08845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP12_08850	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP12_08860	COG1309	transcriptional regulator
UP12_08865	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP12_08870	COG1733	regulation of RNA biosynthetic process
UP12_08880	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP12_08885	COG0251	oxidation-reduction process
UP12_08955	COG0657	acetylesterase activity
UP12_08970	COG2205	protein histidine kinase activity
UP12_08975	COG0745	RESPONSE REGULATOR receiver
UP12_08985	COG3507	Belongs to the glycosyl hydrolase 43 family
UP12_08990	COG1012	belongs to the aldehyde dehydrogenase family
UP12_08995	COG1486	melibiose metabolic process
UP12_09020	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UP12_09035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_09045	COG5444	nuclease activity
UP12_09050	COG1846	Transcriptional regulator
UP12_09055	COG2814	Major facilitator Superfamily
UP12_09065	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_09065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_09065	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_09070	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_09070	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_09070	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP12_09075	COG1105	Belongs to the carbohydrate kinase PfkB family
UP12_09085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP12_09105	COG1012	belongs to the aldehyde dehydrogenase family
UP12_09110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UP12_09115	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP12_09125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP12_09130	COG1024	Enoyl-CoA hydratase
UP12_09135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP12_09140	COG0511	ligase activity, forming carbon-carbon bonds
UP12_09145	COG0439	Biotin carboxylase
UP12_09150	COG0318	PFAM AMP-dependent synthetase and ligase
UP12_09155	COG1960	acyl-CoA dehydrogenase activity
UP12_09160	COG1649	PFAM Uncharacterised BCR, COG1649
UP12_09170	COG1349	DNA-binding transcription factor activity
UP12_09175	COG1942	4-Oxalocrotonate Tautomerase
UP12_09185	COG3835	regulator
UP12_09190	COG0277	FAD linked oxidase domain protein
UP12_09195	COG0247	lactate metabolic process
UP12_09215	COG0166	Belongs to the GPI family
UP12_09225	COG0586	Pfam SNARE associated Golgi protein
UP12_09230	COG1587	Uroporphyrinogen-III synthase
UP12_09240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP12_09260	COG0534	Mate efflux family protein
UP12_09265	COG2027	D-alanyl-D-alanine carboxypeptidase
UP12_09270	COG4677	pectinesterase activity
UP12_09275	COG2323	membrane
UP12_09280	COG2146	nitrite reductase [NAD(P)H] activity
UP12_09285	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP12_09290	COG0493	'glutamate synthase
UP12_09295	COG0070	glutamate synthase
UP12_09295	COG0069	glutamate synthase activity
UP12_09295	COG0067	glutamate synthase
UP12_09300	COG0583	DNA-binding transcription factor activity
UP12_09315	COG4978	Transcriptional regulator
UP12_09315	COG0789	Transcriptional regulator
UP12_09320	COG0454	-acetyltransferase
UP12_09325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP12_09330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP12_09335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP12_09350	COG0243	molybdopterin cofactor binding
UP12_09360	COG1070	Carbohydrate kinase
UP12_09365	COG2115	Belongs to the xylose isomerase family
UP12_09370	COG1940	carbohydrate kinase activity
UP12_09380	COG2211	Major facilitator Superfamily
UP12_09385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP12_09390	COG1994	Peptidase M50
UP12_09410	COG1309	transcriptional regulator
UP12_09415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP12_09420	COG3708	Transcriptional regulator
UP12_09425	COG2378	regulation of single-species biofilm formation
UP12_09435	COG0640	Transcriptional regulator
UP12_09440	COG0531	amino acid
UP12_09445	COG0741	lytic transglycosylase activity
UP12_09450	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
UP12_09455	COG2079	MmgE PrpD family protein
UP12_09460	COG0372	Belongs to the citrate synthase family
UP12_09465	COG2322	membrane
UP12_09475	COG3584	3D domain protein
UP12_09475	COG1388	LysM domain
UP12_09480	COG0514	ATP-dependent DNA helicase (RecQ)
UP12_09485	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP12_09505	COG1012	belongs to the aldehyde dehydrogenase family
UP12_09510	COG1657	PFAM Prenyltransferase squalene oxidase
UP12_09515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UP12_09520	COG0385	Bile acid
UP12_09525	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP12_09530	COG0567	Dehydrogenase, E1 component
UP12_09535	COG4548	von Willebrand factor, type A
UP12_09540	COG0714	Associated with various cellular activities
UP12_09545	COG2032	superoxide dismutase activity
UP12_09550	COG1388	LysM domain
UP12_09550	COG0791	NLP P60 protein
UP12_09555	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UP12_09560	COG0534	Mate efflux family protein
UP12_09565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP12_09570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP12_09580	COG2962	Rard protein
UP12_09595	COG1733	regulation of RNA biosynthetic process
UP12_09600	COG0778	Nitroreductase
UP12_09610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP12_09615	COG0793	Belongs to the peptidase S41A family
UP12_09615	COG3409	Peptidoglycan-binding domain 1 protein
UP12_09620	COG2226	methyltransferase
UP12_09630	COG1876	peptidase activity
UP12_09635	COG0813	purine-nucleoside phosphorylase activity
UP12_09645	COG0671	phosphoesterase, PA-phosphatase related
UP12_09655	COG4479	Belongs to the UPF0346 family
UP12_09665	COG1509	lysine 2,3-aminomutase activity
UP12_09670	COG3829	transcription factor binding
UP12_09675	COG0463	Glycosyl transferase, family 2
UP12_09690	COG4641	Protein conserved in bacteria
UP12_09700	COG1086	Polysaccharide biosynthesis protein
UP12_09705	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP12_09710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP12_09715	COG1846	Transcriptional regulator
UP12_09735	COG4698	Protein conserved in bacteria
UP12_09740	COG2755	lipolytic protein G-D-S-L family
UP12_09745	COG1999	signal sequence binding
UP12_09760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UP12_09765	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
UP12_09770	COG1272	protein, Hemolysin III
UP12_09775	COG0204	Acyl-transferase
UP12_09780	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP12_09785	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
UP12_09790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP12_09800	COG2521	methyltransferase
UP12_09800	COG2136	Putative SAM-dependent methyltransferase
UP12_09810	COG0129	dihydroxy-acid dehydratase activity
UP12_09815	COG1413	lyase activity
UP12_09820	COG1418	mRNA catabolic process
UP12_09825	COG0386	Belongs to the glutathione peroxidase family
UP12_09830	COG2759	Belongs to the formate--tetrahydrofolate ligase family
UP12_09835	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
UP12_09840	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
UP12_09850	COG1278	Cold shock
UP12_09865	COG0328	RNA-DNA hybrid ribonuclease activity
UP12_09870	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
UP12_09875	COG0328	RNA-DNA hybrid ribonuclease activity
UP12_09885	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP12_09895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP12_09900	COG1755	Isoprenylcysteine carboxyl methyltransferase
UP12_09905	COG3424	synthase
UP12_09910	COG0726	polysaccharide deacetylase
UP12_09915	COG2233	PERMEase
UP12_09920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP12_09925	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
UP12_09930	COG1199	ATP-dependent helicase activity
UP12_09940	COG0116	Belongs to the methyltransferase superfamily
UP12_09945	COG3599	regulation of cell shape
UP12_09950	COG4474	Belongs to the UPF0398 family
UP12_09955	COG3359	exonuclease
UP12_09960	COG1205	dead DEAH box helicase
UP12_09960	COG1111	helicase
UP12_09965	COG1902	pentaerythritol trinitrate reductase activity
UP12_09970	COG2190	(PTS) system
UP12_09975	COG0071	Belongs to the small heat shock protein (HSP20) family
UP12_10005	COG3331	DNA recombination
UP12_10010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP12_10010	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP12_10020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UP12_10025	COG3935	DnaD domain protein
UP12_10030	COG0017	Asparaginyl-tRNA synthetase
UP12_10035	COG5353	protein conserved in bacteria
UP12_10040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UP12_10040	COG1199	ATP-dependent helicase activity
UP12_10045	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UP12_10050	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
UP12_10055	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UP12_10065	COG0617	tRNA 3'-terminal CCA addition
UP12_10070	COG0438	transferase activity, transferring glycosyl groups
UP12_10075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP12_10080	COG1803	Methylglyoxal synthase
UP12_10085	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
UP12_10090	COG1694	Mazg nucleotide pyrophosphohydrolase
UP12_10095	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP12_10105	COG4347	Protein of unknown function (DUF1405)
UP12_10110	COG2010	Cytochrome c
UP12_10110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UP12_10115	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UP12_10120	COG0723	plastoquinol--plastocyanin reductase activity
UP12_10130	COG5582	Belongs to the UPF0302 family
UP12_10135	COG0457	Tetratricopeptide repeat
UP12_10140	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UP12_10145	COG0287	Prephenate dehydrogenase
UP12_10150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP12_10155	COG0159	tryptophan synthase activity
UP12_10160	COG0133	tryptophan synthase activity
UP12_10165	COG0135	phosphoribosylanthranilate isomerase activity
UP12_10170	COG0134	indole-3-glycerol-phosphate synthase activity
UP12_10175	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UP12_10185	COG4401	Chorismate mutase type I
UP12_10190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UP12_10195	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UP12_10200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UP12_10205	COG0105	UTP biosynthetic process
UP12_10210	COG0142	geranyltranstransferase activity
UP12_10215	COG2226	methyltransferase
UP12_10220	COG0142	geranyltranstransferase activity
UP12_10230	COG0302	gtp cyclohydrolase
UP12_10235	COG0776	regulation of translation
UP12_10240	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP12_10255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UP12_10260	COG1160	GTP binding
UP12_10280	COG1304	FMN binding
UP12_10285	COG0539	negative regulation of cytoplasmic translation
UP12_10290	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UP12_10300	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
UP12_10305	COG2959	enzyme of heme biosynthesis
UP12_10310	COG3409	Peptidoglycan-binding domain 1 protein
UP12_10310	COG3773	Cell wall hydrolase
UP12_10315	COG2339	peptidase activity
UP12_10320	COG0492	ferredoxin-NADP+ reductase activity
UP12_10325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP12_10330	COG4862	establishment of competence for transformation
UP12_10335	COG1408	metallophosphoesterase
UP12_10345	COG1388	LysM domain
UP12_10350	COG1266	CAAX protease self-immunity
UP12_10355	COG0514	ATP-dependent DNA helicase (RecQ)
UP12_10360	COG4955	Helix-turn-helix domain
UP12_10365	COG1141	Ferredoxin
UP12_10370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
UP12_10375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UP12_10380	COG3409	Peptidoglycan-binding domain 1 protein
UP12_10380	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP12_10390	COG1595	DNA-templated transcription, initiation
UP12_10395	COG5002	protein histidine kinase activity
UP12_10400	COG0745	RESPONSE REGULATOR receiver
UP12_10405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP12_10410	COG1333	cytochrome c biogenesis protein
UP12_10415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_10420	COG1187	pseudouridine synthase activity
UP12_10425	COG0700	Nucleoside recognition
UP12_10430	COG2715	membrane protein required for spore maturation
UP12_10435	COG1686	Belongs to the peptidase S11 family
UP12_10445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UP12_10450	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
UP12_10455	COG1547	Domain of unknown function (DUF309)
UP12_10460	COG0456	acetyltransferase
UP12_10465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UP12_10475	COG0307	riboflavin synthase, alpha
UP12_10495	COG2814	Major facilitator Superfamily
UP12_10500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UP12_10505	COG4086	secreted protein
UP12_10510	COG0019	diaminopimelate decarboxylase activity
UP12_10515	COG0697	spore germination
UP12_10530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP12_10550	COG1191	sigma factor activity
UP12_10555	COG2172	sigma factor antagonist activity
UP12_10565	COG1686	Belongs to the peptidase S11 family
UP12_10570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
UP12_10575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
UP12_10580	COG4974	Belongs to the 'phage' integrase family
UP12_10590	COG0735	belongs to the Fur family
UP12_10595	COG1300	Membrane
UP12_10600	COG1404	Belongs to the peptidase S8 family
UP12_10610	COG2153	protein acetylation
UP12_10615	COG1379	DNA repair
UP12_10620	COG0494	nUDIX hydrolase
UP12_10625	COG0667	Aldo Keto reductase
UP12_10630	COG1733	regulation of RNA biosynthetic process
UP12_10635	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP12_10645	COG1073	alpha beta
UP12_10650	COG0457	Tetratricopeptide repeat
UP12_10660	COG4918	Iron-sulphur cluster biosynthesis
UP12_10665	COG4305	rare lipoprotein A
UP12_10670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP12_10670	COG0456	acetyltransferase
UP12_10675	COG0456	acetyltransferase
UP12_10685	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP12_10695	COG2211	Major facilitator Superfamily
UP12_10700	COG1072	(Pantothenic acid kinase))
UP12_10705	COG0446	pyridine nucleotide-disulphide oxidoreductase
UP12_10710	COG0300	oxidoreductase activity
UP12_10715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP12_10720	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP12_10730	COG4187	Peptidase family M20/M25/M40
UP12_10735	COG1902	pentaerythritol trinitrate reductase activity
UP12_10740	COG0596	Alpha beta hydrolase
UP12_10745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP12_10750	COG1234	tRNA 3'-trailer cleavage
UP12_10755	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UP12_10760	COG2188	Transcriptional regulator
UP12_10765	COG2723	6-phospho-beta-galactosidase activity
UP12_10770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP12_10775	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP12_10780	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP12_10785	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_10790	COG4975	Glucose uptake
UP12_10795	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UP12_10800	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP12_10815	COG0706	membrane insertase activity
UP12_10825	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP12_10830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP12_10835	COG0346	lactoylglutathione lyase activity
UP12_10840	COG1376	ErfK ybiS ycfS ynhG family protein
UP12_10845	COG4129	membrane
UP12_10850	COG1126	abc transporter atp-binding protein
UP12_10855	COG0765	amino acid transport
UP12_10860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_10870	COG1597	lipid kinase activity
UP12_10880	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP12_10885	COG0022	dehydrogenase e1 component
UP12_10890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP12_10895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP12_10900	COG3426	butyrate kinase activity
UP12_10905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP12_10910	COG0280	phosphate acetyltransferase
UP12_10915	COG3829	transcription factor binding
UP12_10915	COG3290	protein histidine kinase activity
UP12_10925	COG0584	glycerophosphoryl diester phosphodiesterase
UP12_10930	COG0457	Tetratricopeptide repeat
UP12_10940	COG0745	RESPONSE REGULATOR receiver
UP12_10945	COG0750	zinc metalloprotease
UP12_10950	COG0497	DNA recombination
UP12_10955	COG1438	arginine binding
UP12_10960	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
UP12_10965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UP12_10970	COG0142	geranyltranstransferase activity
UP12_10975	COG1722	exodeoxyribonuclease VII activity
UP12_10980	COG1570	exodeoxyribonuclease VII activity
UP12_10985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UP12_10990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP12_10995	COG1302	Protein conserved in bacteria
UP12_11000	COG0439	Biotin carboxylase
UP12_11005	COG0511	ligase activity, forming carbon-carbon bonds
UP12_11045	COG3854	ATPases associated with a variety of cellular activities
UP12_11055	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UP12_11060	COG0006	proline dipeptidase activity
UP12_11065	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UP12_11075	COG3872	metal-dependent enzyme
UP12_11085	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP12_11090	COG1321	iron dependent repressor
UP12_11095	COG0095	Lipoate-protein ligase
UP12_11100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP12_11105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP12_11110	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP12_11115	COG0404	The glycine cleavage system catalyzes the degradation of glycine
UP12_11120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP12_11130	COG1396	sequence-specific DNA binding
UP12_11140	COG0681	Belongs to the peptidase S26 family
UP12_11175	COG4970	Tfp pilus assembly protein FimT
UP12_11180	COG4537	Required for transformation and DNA binding
UP12_11185	COG1459	type II secretion system
UP12_11190	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UP12_11200	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_11210	COG1393	Belongs to the ArsC family
UP12_11220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP12_11230	COG0011	TIGRFAM Protein of
UP12_11235	COG2814	Major facilitator Superfamily
UP12_11240	COG2866	Carboxypeptidase
UP12_11245	COG1368	sulfuric ester hydrolase activity
UP12_11250	COG1940	carbohydrate kinase activity
UP12_11255	COG4483	Protein conserved in bacteria
UP12_11260	COG0705	Rhomboid family
UP12_11260	COG0457	Tetratricopeptide repeat
UP12_11270	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UP12_11275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UP12_11285	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UP12_11290	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UP12_11295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UP12_11300	COG0581	inorganic phosphate transmembrane transporter activity
UP12_11305	COG0573	inorganic phosphate transmembrane transporter activity
UP12_11310	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UP12_11320	COG0477	Major facilitator Superfamily
UP12_11325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UP12_11330	COG2839	Protein conserved in bacteria
UP12_11335	COG5521	maltodextrose utilization protein MalA
UP12_11340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP12_11345	COG1388	LysM domain
UP12_11350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UP12_11355	COG4709	membrane
UP12_11360	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
UP12_11365	COG1940	carbohydrate kinase activity
UP12_11370	COG0735	belongs to the Fur family
UP12_11375	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UP12_11380	COG1121	(ABC) transporter
UP12_11385	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP12_11395	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
UP12_11400	COG0513	Belongs to the DEAD box helicase family
UP12_11410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
UP12_11415	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UP12_11420	COG2384	SAM-dependent methyltransferase
UP12_11425	COG2010	Cytochrome c
UP12_11430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UP12_11435	COG0358	DNA primase activity
UP12_11440	COG1671	Belongs to the UPF0178 family
UP12_11445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UP12_11450	COG0517	IMP dehydrogenase activity
UP12_11455	COG0751	glycine-tRNA ligase activity
UP12_11460	COG0752	glycyl-tRNA synthetase alpha subunit
UP12_11465	COG1381	Involved in DNA repair and RecF pathway recombination
UP12_11470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UP12_11475	COG0295	cytidine deaminase activity
UP12_11480	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UP12_11485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
UP12_11490	COG1480	7TM receptor with intracellular HD hydrolase
UP12_11495	COG1702	phosphate starvation-inducible protein PhoH
UP12_11500	COG0561	phosphatase activity
UP12_11515	COG4864	UPF0365 protein
UP12_11520	COG1030	water channel activity
UP12_11525	COG1610	YqeY-like protein
UP12_11530	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UP12_11535	COG1283	sodium-dependent phosphate transmembrane transporter activity
UP12_11540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP12_11545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UP12_11550	COG2264	protein methyltransferase activity
UP12_11555	COG0484	heat shock protein binding
UP12_11560	COG0443	Heat shock 70 kDa protein
UP12_11565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UP12_11570	COG1420	regulation of RNA biosynthetic process
UP12_11575	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP12_11580	COG0481	GTPase activity
UP12_11590	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP12_11595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UP12_11600	COG0268	Binds directly to 16S ribosomal RNA
UP12_11605	COG1466	dna polymerase III delta subunit
UP12_11615	COG2333	competence protein COMEC
UP12_11615	COG0658	competence protein
UP12_11620	COG2131	deaminase
UP12_11625	COG1555	photosystem II stabilization
UP12_11630	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP12_11635	COG2226	methyltransferase
UP12_11640	COG0799	negative regulation of ribosome biogenesis
UP12_11645	COG1713	HD superfamily hydrolase involved in NAD metabolism
UP12_11650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UP12_11655	COG1534	Rna-binding protein
UP12_11660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UP12_11665	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP12_11670	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
UP12_11680	COG2755	lipolytic protein G-D-S-L family
UP12_11690	COG0457	Tetratricopeptide repeat
UP12_11720	COG0726	polysaccharide deacetylase
UP12_11750	COG2160	L-arabinose isomerase activity
UP12_11765	COG1609	Transcriptional regulator
UP12_11775	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
UP12_11780	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
UP12_11785	COG1733	regulation of RNA biosynthetic process
UP12_11805	COG2602	Beta-lactamase
UP12_11810	COG1960	acyl-CoA dehydrogenase activity
UP12_11815	COG1126	abc transporter atp-binding protein
UP12_11820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_11825	COG0765	amino acid transport
UP12_11835	COG3546	catalase activity
UP12_11840	COG1063	alcohol dehydrogenase
UP12_11850	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_11860	COG1115	amino acid carrier protein
UP12_11865	COG0583	DNA-binding transcription factor activity
UP12_11870	COG1063	alcohol dehydrogenase
UP12_11875	COG2226	methyltransferase
UP12_11885	COG0626	cystathionine gamma-synthase activity
UP12_11890	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP12_11895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UP12_11900	COG2226	methyltransferase
UP12_11915	COG0768	penicillin binding
UP12_11920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UP12_11930	COG0572	uridine kinase
UP12_11950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UP12_11955	COG0183	Belongs to the thiolase family
UP12_11960	COG0318	PFAM AMP-dependent synthetase and ligase
UP12_11965	COG1268	BioY protein
UP12_11970	COG3906	Belongs to the UPF0473 family
UP12_11975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UP12_11980	COG4472	Bacterial protein of unknown function (DUF965)
UP12_11985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
UP12_11990	COG0628	permease
UP12_11995	COG1126	abc transporter atp-binding protein
UP12_12000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_12005	COG0765	amino acid transport
UP12_12010	COG0765	amino acid transport
UP12_12020	COG3881	PFAM PRC-barrel domain
UP12_12025	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UP12_12030	COG0457	Tetratricopeptide repeat
UP12_12035	COG0482	sulfurtransferase activity
UP12_12040	COG1104	cysteine desulfurase activity
UP12_12045	COG1959	2 iron, 2 sulfur cluster binding
UP12_12050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UP12_12055	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UP12_12065	COG0124	histidyl-tRNA synthetase
UP12_12070	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP12_12070	COG3103	Sh3 type 3 domain protein
UP12_12070	COG4991	sh3 domain protein
UP12_12075	COG1490	D-aminoacyl-tRNA deacylase activity
UP12_12080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UP12_12085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP12_12090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UP12_12090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
UP12_12095	COG5416	Lipopolysaccharide assembly protein A domain
UP12_12100	COG0490	domain, Protein
UP12_12105	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP12_12105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP12_12115	COG2244	polysaccharide biosynthetic process
UP12_12120	COG2323	membrane
UP12_12130	COG1862	Preprotein translocase
UP12_12135	COG0343	queuine tRNA-ribosyltransferase activity
UP12_12140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UP12_12150	COG2255	four-way junction helicase activity
UP12_12155	COG0632	four-way junction helicase activity
UP12_12165	COG2112	serine threonine protein kinase
UP12_12175	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UP12_12190	COG1388	LysM domain
UP12_12195	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
UP12_12200	COG0157	Belongs to the NadC ModD family
UP12_12205	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UP12_12210	COG1104	cysteine desulfurase activity
UP12_12215	COG1827	regulation of RNA biosynthetic process
UP12_12220	COG0077	Prephenate dehydratase
UP12_12225	COG4492	Belongs to the UPF0735 family
UP12_12230	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UP12_12235	COG3290	protein histidine kinase activity
UP12_12240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UP12_12245	COG2868	ribosomal protein
UP12_12250	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UP12_12255	COG1994	Peptidase M50
UP12_12260	COG0739	heme binding
UP12_12265	COG2894	cell division
UP12_12270	COG0850	regulation of cytokinetic process
UP12_12275	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
UP12_12280	COG1792	Involved in formation and maintenance of cell shape
UP12_12285	COG1077	Cell shape determining protein MreB Mrl
UP12_12290	COG2003	Belongs to the UPF0758 family
UP12_12295	COG0424	maF-like protein
UP12_12305	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
UP12_12310	COG0285	dihydrofolate synthase activity
UP12_12315	COG0525	valine-tRNA ligase activity
UP12_12325	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP12_12330	COG1388	LysM domain
UP12_12335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP12_12340	COG0113	porphobilinogen synthase activity
UP12_12345	COG1587	Uroporphyrinogen-III synthase
UP12_12350	COG0181	hydroxymethylbilane synthase activity
UP12_12355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP12_12360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
UP12_12370	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UP12_12375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UP12_12380	COG0470	DNA polymerase III
UP12_12380	COG1067	ATP-dependent peptidase activity
UP12_12385	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UP12_12390	COG0544	peptidyl-prolyl cis-trans isomerase activity
UP12_12395	COG1477	protein flavinylation
UP12_12395	COG0457	Tetratricopeptide repeat
UP12_12400	COG0066	3-isopropylmalate dehydratase activity
UP12_12405	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UP12_12410	COG0473	3-isopropylmalate dehydrogenase activity
UP12_12415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP12_12420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UP12_12425	COG0440	acetolactate synthase activity
UP12_12430	COG0028	Belongs to the TPP enzyme family
UP12_12435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP12_12440	COG2706	6-phosphogluconolactonase activity
UP12_12445	COG3339	Conserved Protein
UP12_12450	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
UP12_12455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP12_12460	COG1696	Membrane protein involved in D-alanine export
UP12_12475	COG5444	nuclease activity
UP12_12510	COG0622	Phosphoesterase
UP12_12515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UP12_12520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
UP12_12525	COG5401	PFAM Sporulation and spore germination
UP12_12530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UP12_12535	COG1846	Transcriptional regulator
UP12_12560	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP12_12565	COG4824	toxin secretion phage lysis holin
UP12_12585	COG1388	LysM domain
UP12_12585	COG1705	Flagellar rod assembly protein muramidase FlgJ
UP12_12595	COG5412	phage tail tape measure protein
UP12_12595	COG3953	SLT domain
UP12_12695	COG0582	viral genome integration into host DNA
UP12_12700	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
UP12_12785	COG2197	response regulator
UP12_12790	COG2851	Citrate transporter
UP12_12795	COG0583	DNA-binding transcription factor activity
UP12_12800	COG2828	Protein conserved in bacteria
UP12_12810	COG0824	Thioesterase
UP12_12815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UP12_12820	COG1053	succinate dehydrogenase
UP12_12825	COG2009	succinate dehydrogenase
UP12_12830	COG1719	4-vinyl reductase, 4VR
UP12_12835	COG0527	aspartate kinase activity
UP12_12840	COG0322	excinuclease ABC activity
UP12_12845	COG3118	belongs to the thioredoxin family
UP12_12850	COG3534	alpha-L-arabinofuranosidase
UP12_12855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UP12_12860	COG2086	electron transfer activity
UP12_12865	COG1024	Enoyl-CoA hydratase
UP12_12870	COG1309	transcriptional regulator
UP12_12875	COG0318	PFAM AMP-dependent synthetase and ligase
UP12_12885	COG3766	membrane
UP12_12890	COG1193	negative regulation of DNA recombination
UP12_12895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP12_12895	COG1796	DNA polymerase
UP12_12900	COG1286	toxin biosynthetic process
UP12_12905	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
UP12_12910	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP12_12915	COG0072	phenylalanine-tRNA ligase activity
UP12_12915	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP12_12920	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UP12_12925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP12_12935	COG1966	Carbon starvation protein
UP12_12940	COG1363	Peptidase, m42
UP12_12950	COG3326	Membrane
UP12_12955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UP12_12960	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UP12_12965	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UP12_12970	COG1346	cytolysis
UP12_12980	COG3279	Response regulator of the LytR AlgR family
UP12_12985	COG3275	phosphorelay sensor kinase activity
UP12_13000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP12_13010	COG0398	Pfam SNARE associated Golgi protein
UP12_13015	COG1484	DNA-dependent DNA replication
UP12_13020	COG3611	Membrane attachment protein
UP12_13025	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UP12_13035	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UP12_13040	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP12_13045	COG0237	dephospho-CoA kinase activity
UP12_13050	COG1971	Probably functions as a manganese efflux pump
UP12_13055	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UP12_13060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP12_13060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP12_13065	COG5002	protein histidine kinase activity
UP12_13070	COG0745	RESPONSE REGULATOR receiver
UP12_13075	COG0039	L-malate dehydrogenase activity
UP12_13080	COG0538	isocitrate dehydrogenase activity
UP12_13085	COG0372	Belongs to the citrate synthase family
UP12_13090	COG2707	UPF0756 membrane protein
UP12_13095	COG0628	permease
UP12_13100	COG3030	protein affecting phage T7 exclusion by the F plasmid
UP12_13110	COG0205	6-phosphofructokinase activity
UP12_13115	COG0825	malonyl-CoA metabolic process
UP12_13120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UP12_13125	COG0281	malic enzyme
UP12_13130	COG0587	DNA-directed DNA polymerase activity
UP12_13150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UP12_13160	COG4109	DRTGG domain
UP12_13165	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP12_13170	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_13180	COG0165	Argininosuccinate lyase
UP12_13185	COG0137	argininosuccinate synthase activity
UP12_13190	COG0521	Mo-molybdopterin cofactor biosynthetic process
UP12_13195	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UP12_13200	COG0827	DNA restriction-modification system
UP12_13205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UP12_13210	COG3874	Sporulation protein YtfJ
UP12_13220	COG1714	RDD family
UP12_13225	COG0616	signal peptide processing
UP12_13230	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP12_13240	COG3239	Fatty acid desaturase
UP12_13245	COG4585	Histidine kinase
UP12_13250	COG2197	response regulator
UP12_13255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_13260	COG0745	RESPONSE REGULATOR receiver
UP12_13265	COG2205	protein histidine kinase activity
UP12_13270	COG0772	Belongs to the SEDS family
UP12_13275	COG1695	Transcriptional regulator
UP12_13280	COG1136	(ABC) transporter
UP12_13285	COG0577	efflux transmembrane transporter activity
UP12_13290	COG0402	S-adenosylhomocysteine deaminase activity
UP12_13295	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP12_13305	COG1279	arginine transmembrane transporter activity
UP12_13310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP12_13320	COG0301	tRNA thio-modification
UP12_13325	COG1104	cysteine desulfurase activity
UP12_13330	COG1114	Component of the transport system for branched-chain amino acids
UP12_13335	COG1114	Component of the transport system for branched-chain amino acids
UP12_13340	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
UP12_13345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP12_13350	COG1309	transcriptional regulator
UP12_13355	COG1956	GAF domain-containing protein
UP12_13360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UP12_13375	COG1335	isochorismatase
UP12_13385	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
UP12_13390	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UP12_13395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP12_13400	COG0454	-acetyltransferase
UP12_13405	COG0517	IMP dehydrogenase activity
UP12_13410	COG0123	including yeast histone deacetylase and acetoin utilization protein
UP12_13415	COG1609	Transcriptional regulator
UP12_13420	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
UP12_13420	COG1605	Chorismate mutase
UP12_13425	COG3118	belongs to the thioredoxin family
UP12_13430	COG4980	gas vesicle protein
UP12_13435	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
UP12_13440	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
UP12_13445	COG1674	ftsk spoiiie
UP12_13450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP12_13455	COG4848	Belongs to the UPF0354 family
UP12_13460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_13475	COG1363	Peptidase, m42
UP12_13480	COG5584	Small secreted protein
UP12_13485	COG0281	malic enzyme
UP12_13490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP12_13495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UP12_13505	COG0510	thiamine kinase activity
UP12_13510	COG1597	lipid kinase activity
UP12_13520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UP12_13525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP12_13530	COG3340	Belongs to the peptidase S51 family
UP12_13535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP12_13540	COG2252	PERMEase
UP12_13545	COG1349	DNA-binding transcription factor activity
UP12_13550	COG1187	pseudouridine synthase activity
UP12_13555	COG2244	polysaccharide biosynthetic process
UP12_13560	COG2081	HI0933 family
UP12_13570	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
UP12_13575	COG3196	Protein conserved in bacteria
UP12_13585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP12_13590	COG5578	integral membrane protein
UP12_13595	COG0673	inositol 2-dehydrogenase activity
UP12_13600	COG1653	transport
UP12_13605	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
UP12_13610	COG4209	transmembrane transport
UP12_13615	COG2207	Transcriptional regulator
UP12_13620	COG1733	regulation of RNA biosynthetic process
UP12_13625	COG2814	Major facilitator Superfamily
UP12_13630	COG0656	L-ascorbic acid biosynthetic process
UP12_13635	COG1653	transport
UP12_13640	COG0395	ABC-type sugar transport system, permease component
UP12_13645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP12_13650	COG1073	alpha beta
UP12_13655	COG0495	leucyl-tRNA aminoacylation
UP12_13665	COG2202	Pas domain
UP12_13665	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_13670	COG2433	Pfam Transposase IS66
UP12_13675	COG0577	efflux transmembrane transporter activity
UP12_13680	COG1136	(ABC) transporter
UP12_13690	COG1131	(ABC) transporter
UP12_13695	COG1725	Transcriptional regulator
UP12_13710	COG1242	4 iron, 4 sulfur cluster binding
UP12_13715	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
UP12_13725	COG2267	carboxylic ester hydrolase activity
UP12_13730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UP12_13735	COG0367	asparagine synthase
UP12_13740	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UP12_13745	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
UP12_13755	COG1506	peptidase
UP12_13760	COG1233	COG1233 Phytoene dehydrogenase and related
UP12_13780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP12_13785	COG1116	anion transmembrane transporter activity
UP12_13790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP12_13795	COG0494	nUDIX hydrolase
UP12_13800	COG2310	stress, protein
UP12_13815	COG4824	toxin secretion phage lysis holin
UP12_13825	COG0783	Belongs to the Dps family
UP12_13840	COG1854	S-ribosylhomocysteine lyase activity
UP12_13845	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UP12_13850	COG0288	reversible hydration of carbon dioxide
UP12_13855	COG0803	Belongs to the bacterial solute-binding protein 9 family
UP12_13855	COG3443	Belongs to the bacterial solute-binding protein 9 family
UP12_13870	COG1271	oxidase subunit
UP12_13875	COG1294	oxidase, subunit
UP12_13890	COG4948	Mandelate Racemase Muconate Lactonizing
UP12_13895	COG0318	PFAM AMP-dependent synthetase and ligase
UP12_13900	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UP12_13905	COG0596	Alpha beta hydrolase
UP12_13910	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
UP12_13915	COG1169	isochorismate synthase
UP12_13920	COG1575	Belongs to the MenA family. Type 1 subfamily
UP12_13925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP12_14055	COG3859	Proton-coupled thiamine transporter YuaJ
UP12_14065	COG1247	-acetyltransferase
UP12_14070	COG3339	Conserved Protein
UP12_14075	COG0772	Belongs to the SEDS family
UP12_14080	COG0772	Belongs to the SEDS family
UP12_14085	COG2268	Band 7 protein
UP12_14090	COG1585	Membrane protein implicated in regulation of membrane protease activity
UP12_14095	COG2318	DinB family
UP12_14100	COG1454	alcohol dehydrogenase
UP12_14110	COG1510	regulation of RNA biosynthetic process
UP12_14115	COG0457	Tetratricopeptide repeat
UP12_14135	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP12_14135	COG3409	Peptidoglycan-binding domain 1 protein
UP12_14170	COG3778	Protein conserved in bacteria
UP12_14175	COG3299	homolog of phage Mu protein gp47
UP12_14180	COG3628	GPW Gp25 family protein
UP12_14190	COG4193	domain, Protein
UP12_14195	COG1652	LysM domain
UP12_14200	COG3953	SLT domain
UP12_14200	COG3953	SLT domain
UP12_14200	COG5280	Phage tail tape measure protein TP901
UP12_14200	COG5280	Phage tail tape measure protein TP901
UP12_14255	COG4653	Phage capsid family
UP12_14260	COG0338	D12 class N6 adenine-specific DNA methyltransferase
UP12_14270	COG2369	cell adhesion
UP12_14275	COG5518	Phage portal protein
UP12_14280	COG1783	phage Terminase large subunit
UP12_14415	COG0305	Participates in initiation and elongation during chromosome replication
UP12_14490	COG2856	Zn peptidase
UP12_14495	COG0582	viral genome integration into host DNA
UP12_14510	COG5632	N-Acetylmuramoyl-L-alanine amidase
UP12_14510	COG3409	Peptidoglycan-binding domain 1 protein
UP12_14550	COG3778	Protein conserved in bacteria
UP12_14555	COG3299	homolog of phage Mu protein gp47
UP12_14560	COG3628	GPW Gp25 family protein
UP12_14570	COG4193	domain, Protein
UP12_14575	COG1652	LysM domain
UP12_14580	COG3953	SLT domain
UP12_14580	COG5280	Phage tail tape measure protein TP901
UP12_14580	COG3953	SLT domain
UP12_14580	COG5280	Phage tail tape measure protein TP901
UP12_14625	COG4653	Phage capsid family
UP12_14630	COG0338	D12 class N6 adenine-specific DNA methyltransferase
UP12_14635	COG5518	Phage portal protein
UP12_14640	COG1783	phage Terminase large subunit
UP12_14645	COG5484	DNA packaging
UP12_14650	COG1595	DNA-templated transcription, initiation
UP12_14660	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
UP12_14675	COG1396	sequence-specific DNA binding
UP12_14685	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UP12_14695	COG1968	undecaprenyl-diphosphatase activity
UP12_14700	COG0628	permease
UP12_14710	COG0673	inositol 2-dehydrogenase activity
UP12_14715	COG0693	protein deglycase activity
UP12_14720	COG0840	transmembrane signaling receptor activity
UP12_14725	COG0840	transmembrane signaling receptor activity
UP12_14730	COG0840	transmembrane signaling receptor activity
UP12_14735	COG0840	transmembrane signaling receptor activity
UP12_14750	COG2070	2-Nitropropane dioxygenase
UP12_14755	COG0432	Pfam Uncharacterised protein family UPF0047
UP12_14760	COG1253	flavin adenine dinucleotide binding
UP12_14765	COG2738	Putative neutral zinc metallopeptidase
UP12_14775	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UP12_14790	COG0166	Belongs to the GPI family
UP12_14795	COG1979	alcohol dehydrogenase
UP12_14800	COG1979	alcohol dehydrogenase
UP12_14805	COG2155	Conserved Protein
UP12_14810	COG1098	S1 RNA binding domain
UP12_14815	COG0436	Aminotransferase
UP12_14820	COG1522	sequence-specific DNA binding
UP12_14825	COG2267	carboxylic ester hydrolase activity
UP12_14835	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UP12_14840	COG2205	protein histidine kinase activity
UP12_14855	COG5018	Exonuclease
UP12_14860	COG2814	Major facilitator Superfamily
UP12_14865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP12_14870	COG3011	Protein conserved in bacteria
UP12_14880	COG3290	protein histidine kinase activity
UP12_14885	COG4565	transcriptional regulatory protein
UP12_14910	COG3493	citrate carrier protein
UP12_14920	COG2111	Na H antiporter
UP12_14920	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UP12_14925	COG2111	Na H antiporter
UP12_14930	COG1006	Multisubunit Na H antiporter MnhC subunit
UP12_14935	COG0651	ATP synthesis coupled electron transport
UP12_14940	COG1863	multisubunit Na H antiporter MnhE subunit
UP12_14945	COG2212	antiporter activity
UP12_14950	COG1320	monovalent cation:proton antiporter activity
UP12_14955	COG2050	protein possibly involved in aromatic compounds catabolism
UP12_14960	COG2197	response regulator
UP12_14965	COG4585	Histidine kinase
UP12_14970	COG0142	geranyltranstransferase activity
UP12_14985	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
UP12_14990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UP12_14995	COG1335	isochorismatase
UP12_15000	COG5506	Protein of unknown function (DUF1694)
UP12_15020	COG0628	permease
UP12_15035	COG1418	mRNA catabolic process
UP12_15040	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_15050	COG1511	domain protein
UP12_15055	COG1674	ftsk spoiiie
UP12_15055	COG0433	COG0433 Predicted ATPase
UP12_15060	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP12_15065	COG5417	Belongs to the EsaB family
UP12_15070	COG4842	Belongs to the WXG100 family
UP12_15075	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP12_15075	COG2508	Transcriptional regulator
UP12_15080	COG0686	Belongs to the AlaDH PNT family
UP12_15085	COG1268	BioY protein
UP12_15090	COG4326	sporulation control protein
UP12_15095	COG2056	Na+-H+ antiporter family
UP12_15100	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UP12_15105	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
UP12_15110	COG3584	3D domain protein
UP12_15120	COG1252	NADH dehydrogenase
UP12_15125	COG0492	ferredoxin-NADP+ reductase activity
UP12_15140	COG0316	Belongs to the HesB IscA family
UP12_15145	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UP12_15150	COG4844	belongs to the
UP12_15155	COG1252	NADH dehydrogenase
UP12_15165	COG4837	Protein of unknown function (DUF1462)
UP12_15170	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
UP12_15175	COG0823	Involved in the tonB-independent uptake of proteins
UP12_15175	COG4946	Tricorn protease homolog
UP12_15175	COG1506	peptidase
UP12_15180	COG0083	homoserine kinase activity
UP12_15185	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UP12_15190	COG0460	homoserine dehydrogenase
UP12_15195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP12_15200	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP12_15205	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP12_15210	COG0647	UMP catabolic process
UP12_15215	COG2445	Protein of unknown function DUF86
UP12_15220	COG4470	Protein conserved in bacteria
UP12_15230	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UP12_15240	COG0739	heme binding
UP12_15250	COG3377	Domain of unknown function (DUF1805)
UP12_15255	COG0737	Belongs to the 5'-nucleotidase family
UP12_15260	COG1801	Protein of unknown function DUF72
UP12_15265	COG2508	Transcriptional regulator
UP12_15270	COG2140	Oxalate decarboxylase
UP12_15275	COG2814	Major facilitator Superfamily
UP12_15280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
UP12_15285	COG2356	endonuclease I
UP12_15295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_15300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_15305	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_15325	COG0642	Histidine kinase
UP12_15325	COG5002	protein histidine kinase activity
UP12_15330	COG0745	RESPONSE REGULATOR receiver
UP12_15335	COG2311	Membrane
UP12_15345	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP12_15365	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
UP12_15375	COG0719	Fe-S assembly protein
UP12_15380	COG0822	iron-sulfur transferase activity
UP12_15385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UP12_15390	COG0719	Fe-S assembly protein
UP12_15395	COG0396	ATPase activity
UP12_15400	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UP12_15405	COG1464	Belongs to the NlpA lipoprotein family
UP12_15410	COG2011	ABC-type metal ion transport system permease component
UP12_15415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UP12_15425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_15430	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UP12_15440	COG0509	glycine decarboxylation via glycine cleavage system
UP12_15445	COG1393	Belongs to the ArsC family
UP12_15450	COG1960	acyl-CoA dehydrogenase activity
UP12_15455	COG0183	Belongs to the thiolase family
UP12_15460	COG1024	Enoyl-CoA hydratase
UP12_15460	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP12_15470	COG5577	PFAM Coat F domain
UP12_15480	COG1120	ATPase activity
UP12_15490	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_15495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP12_15500	COG0745	RESPONSE REGULATOR receiver
UP12_15505	COG2205	protein histidine kinase activity
UP12_15505	COG2770	Histidine kinase
UP12_15510	COG1309	transcriptional regulator
UP12_15515	COG0114	fumarate hydratase activity
UP12_15520	COG0697	spore germination
UP12_15525	COG0814	amino acid
UP12_15540	COG2197	response regulator
UP12_15545	COG4585	Histidine kinase
UP12_15550	COG4758	membrane
UP12_15560	COG1842	Phage shock protein A
UP12_15565	COG4758	membrane
UP12_15575	COG1120	ATPase activity
UP12_15580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_15585	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_15595	COG2721	sulfolactate sulfo-lyase activity
UP12_15600	COG0246	Mannitol dehydrogenase
UP12_15605	COG1609	Transcriptional regulator
UP12_15610	COG1904	glucuronate isomerase
UP12_15615	COG2205	protein histidine kinase activity
UP12_15620	COG0745	RESPONSE REGULATOR receiver
UP12_15625	COG1120	ATPase activity
UP12_15630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_15635	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_15640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_15645	COG0531	amino acid
UP12_15665	COG1988	membrane-bound metal-dependent
UP12_15670	COG1368	sulfuric ester hydrolase activity
UP12_15675	COG0725	ABC transporter, periplasmic molybdate-binding protein
UP12_15680	COG4149	molybdate abc transporter
UP12_15685	COG0656	L-ascorbic acid biosynthetic process
UP12_15690	COG1940	carbohydrate kinase activity
UP12_15695	COG0025	NhaP-type Na H and K H
UP12_15700	COG2860	membrane
UP12_15705	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
UP12_15710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
UP12_15715	COG2217	Heavy metal translocating P-type atpase
UP12_15720	COG1121	(ABC) transporter
UP12_15725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UP12_15730	COG0803	Belongs to the bacterial solute-binding protein 9 family
UP12_15740	COG3226	Transcriptional regulator
UP12_15745	COG0784	Response regulator, receiver
UP12_15750	COG4191	Histidine kinase
UP12_15755	COG1027	Aspartate ammonia-lyase
UP12_15765	COG2217	Heavy metal translocating P-type atpase
UP12_15770	COG2608	mercury ion transmembrane transporter activity
UP12_15775	COG1937	Protein conserved in bacteria
UP12_15785	COG0745	RESPONSE REGULATOR receiver
UP12_15785	COG3706	GGDEF domain
UP12_15800	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UP12_15805	COG0557	exoribonuclease II activity
UP12_15810	COG1647	Serine aminopeptidase, S33
UP12_15815	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP12_15820	COG2002	toxin-antitoxin pair type II binding
UP12_15825	COG1476	TRANSCRIPTIONal
UP12_15830	COG1396	sequence-specific DNA binding
UP12_15835	COG1396	sequence-specific DNA binding
UP12_15840	COG1733	regulation of RNA biosynthetic process
UP12_15845	COG1174	glycine betaine transport
UP12_15850	COG1732	Glycine betaine
UP12_15855	COG1174	glycine betaine transport
UP12_15860	COG1125	glycine betaine transport
UP12_15860	COG0517	IMP dehydrogenase activity
UP12_15865	COG1510	regulation of RNA biosynthetic process
UP12_15870	COG2095	MarC family integral membrane protein
UP12_15880	COG0456	acetyltransferase
UP12_15900	COG1131	(ABC) transporter
UP12_15910	COG0148	phosphopyruvate hydratase activity
UP12_15915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
UP12_15920	COG0149	triose-phosphate isomerase activity
UP12_15925	COG0126	phosphoglycerate kinase activity
UP12_15930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP12_15935	COG2390	Transcriptional regulator
UP12_15940	COG0833	amino acid
UP12_15945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UP12_15950	COG3829	transcription factor binding
UP12_15955	COG2186	Transcriptional regulator
UP12_15960	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UP12_15970	COG0534	Mate efflux family protein
UP12_15975	COG4608	Belongs to the ABC transporter superfamily
UP12_15980	COG0444	Belongs to the ABC transporter superfamily
UP12_15985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP12_15990	COG0601	transmembrane transport
UP12_15995	COG0747	negative chemotaxis
UP12_16000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UP12_16005	COG0110	maltose O-acetyltransferase activity
UP12_16010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UP12_16015	COG2244	polysaccharide biosynthetic process
UP12_16020	COG5039	Polysaccharide pyruvyl transferase
UP12_16025	COG1216	Glycosyl transferase, family 2
UP12_16035	COG0438	transferase activity, transferring glycosyl groups
UP12_16040	COG1215	transferase activity, transferring glycosyl groups
UP12_16045	COG0438	transferase activity, transferring glycosyl groups
UP12_16050	COG1086	Polysaccharide biosynthesis protein
UP12_16055	COG0489	protein tyrosine kinase activity
UP12_16060	COG3944	biosynthesis protein
UP12_16065	COG1396	sequence-specific DNA binding
UP12_16075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_16080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_16085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP12_16090	COG0726	polysaccharide deacetylase
UP12_16100	COG1124	(ABC) transporter
UP12_16115	COG0601	transmembrane transport
UP12_16120	COG0747	negative chemotaxis
UP12_16125	COG1819	glycosyl
UP12_16150	COG0740	serine-type endopeptidase activity
UP12_16155	COG1611	Belongs to the LOG family
UP12_16160	COG1694	Mazg nucleotide pyrophosphohydrolase
UP12_16165	COG0659	secondary active sulfate transmembrane transporter activity
UP12_16170	COG0288	reversible hydration of carbon dioxide
UP12_16175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP12_16185	COG1301	dicarboxylic acid transport
UP12_16190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UP12_16200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
UP12_16205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_16210	COG1481	regulation of sporulation
UP12_16215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UP12_16220	COG1660	Displays ATPase and GTPase activities
UP12_16225	COG1051	belongs to the nudix hydrolase family
UP12_16230	COG0492	ferredoxin-NADP+ reductase activity
UP12_16235	COG3883	PFAM NLP P60 protein
UP12_16235	COG0791	NLP P60 protein
UP12_16240	COG0457	Tetratricopeptide repeat
UP12_16245	COG0140	phosphoribosyl-ATP diphosphatase activity
UP12_16245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UP12_16250	COG0107	imidazoleglycerol-phosphate synthase activity
UP12_16255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UP12_16260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UP12_16265	COG0131	Imidazoleglycerol-phosphate dehydratase
UP12_16270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UP12_16275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UP12_16280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
UP12_16285	COG4990	cell redox homeostasis
UP12_16295	COG2910	NAD(P)H-binding
UP12_16300	COG1959	2 iron, 2 sulfur cluster binding
UP12_16305	COG0110	maltose O-acetyltransferase activity
UP12_16310	COG0546	phosphoglycolate phosphatase activity
UP12_16315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UP12_16320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UP12_16325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
UP12_16330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP12_16335	COG0363	glucosamine-6-phosphate deaminase activity
UP12_16345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UP12_16350	COG1950	PFAM Membrane protein of
UP12_16355	COG1983	PspC domain protein
UP12_16360	COG3595	metallopeptidase activity
UP12_16375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UP12_16385	COG4897	Protein conserved in bacteria
UP12_16395	COG3848	Pyruvate phosphate dikinase
UP12_16395	COG0574	Belongs to the PEP-utilizing enzyme family
UP12_16400	COG1309	transcriptional regulator
UP12_16405	COG2814	Major facilitator Superfamily
UP12_16415	COG0745	RESPONSE REGULATOR receiver
UP12_16420	COG5002	protein histidine kinase activity
UP12_16425	COG1113	amino acid transport
UP12_16430	COG0778	Nitroreductase
UP12_16435	COG1733	regulation of RNA biosynthetic process
UP12_16440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP12_16450	COG0793	Belongs to the peptidase S41A family
UP12_16450	COG3409	Peptidoglycan-binding domain 1 protein
UP12_16455	COG0730	response to heat
UP12_16460	COG3883	PFAM NLP P60 protein
UP12_16460	COG0791	NLP P60 protein
UP12_16465	COG2177	Part of the ABC transporter FtsEX involved in
UP12_16470	COG2884	Cell division ATP-binding protein ftsE
UP12_16475	COG2010	Cytochrome c
UP12_16480	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP12_16495	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UP12_16500	COG0653	protein targeting
UP12_16505	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UP12_16510	COG0840	transmembrane signaling receptor activity
UP12_16525	COG1516	flagellar protein fliS
UP12_16530	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UP12_16535	COG1334	flagellar protein FlaG
UP12_16540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UP12_16545	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UP12_16555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP12_16560	COG4786	Flagellar basal body rod
UP12_16560	COG1256	bacterial-type flagellum assembly
UP12_16565	COG3418	PFAM FlgN family protein
UP12_16580	COG1040	competence protein
UP12_16590	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
UP12_16595	COG1307	EDD domain protein, DegV family
UP12_16600	COG2197	response regulator
UP12_16605	COG4585	Histidine kinase
UP12_16610	COG1739	Uncharacterized protein family UPF0029
UP12_16615	COG1316	TRANSCRIPTIONal
UP12_16620	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP12_16625	COG0438	transferase activity, transferring glycosyl groups
UP12_16630	COG1215	transferase activity, transferring glycosyl groups
UP12_16635	COG3206	protein involved in exopolysaccharide biosynthesis
UP12_16640	COG3307	-O-antigen
UP12_16645	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP12_16650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UP12_16655	COG0438	transferase activity, transferring glycosyl groups
UP12_16655	COG0297	glycogen (starch) synthase activity
UP12_16660	COG2244	polysaccharide biosynthetic process
UP12_16675	COG2247	cell wall binding repeat
UP12_16675	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP12_16680	COG2385	sporulation resulting in formation of a cellular spore
UP12_16680	COG2247	cell wall binding repeat
UP12_16690	COG1316	TRANSCRIPTIONal
UP12_16695	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UP12_16700	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP12_16705	COG1134	teichoic acid transport
UP12_16710	COG1682	transport, permease protein
UP12_16715	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP12_16715	COG0463	Glycosyl transferase, family 2
UP12_16720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP12_16730	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UP12_16735	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
UP12_16740	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP12_16745	COG4193	domain, Protein
UP12_16750	COG1482	cell wall glycoprotein biosynthetic process
UP12_16760	COG1175	transmembrane transport
UP12_16765	COG1653	transport
UP12_16770	COG2197	response regulator
UP12_16775	COG2972	Histidine kinase
UP12_16785	COG0454	-acetyltransferase
UP12_16790	COG0800	Aldolase
UP12_16795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP12_16800	COG1609	Transcriptional regulator
UP12_16805	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
UP12_16810	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_16815	COG0697	spore germination
UP12_16820	COG0814	amino acid
UP12_16830	COG1215	transferase activity, transferring glycosyl groups
UP12_16835	COG2814	Major facilitator Superfamily
UP12_16840	COG1316	TRANSCRIPTIONal
UP12_16845	COG0561	phosphatase activity
UP12_16850	COG0791	NLP P60 protein
UP12_16855	COG2843	Capsule synthesis protein
UP12_16865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UP12_16870	COG0697	spore germination
UP12_16885	COG1609	Transcriptional regulator
UP12_16890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP12_16895	COG1869	D-ribose catabolic process
UP12_16900	COG1129	ABC transporter
UP12_16905	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP12_16910	COG1879	ABC-type sugar transport system periplasmic component
UP12_16915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UP12_16920	COG0583	DNA-binding transcription factor activity
UP12_16925	COG0028	Belongs to the TPP enzyme family
UP12_16930	COG3527	Alpha-acetolactate decarboxylase
UP12_16935	COG1522	sequence-specific DNA binding
UP12_16940	COG2059	Chromate
UP12_16945	COG2059	Chromate
UP12_16950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UP12_16955	COG4715	Zinc finger, swim domain protein
UP12_16960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP12_16965	COG1366	Belongs to the anti-sigma-factor antagonist family
UP12_16965	COG2202	Pas domain
UP12_16970	COG0561	phosphatase activity
UP12_16985	COG1970	mechanosensitive ion channel activity
UP12_16990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
UP12_16995	COG0457	Tetratricopeptide repeat
UP12_17000	COG4786	Flagellar basal body rod
UP12_17005	COG4786	Flagellar basal body rod
UP12_17010	COG1077	Cell shape determining protein MreB Mrl
UP12_17015	COG1609	Transcriptional regulator
UP12_17020	COG1846	Transcriptional regulator
UP12_17025	COG2814	Major facilitator Superfamily
UP12_17030	COG0671	phosphoesterase, PA-phosphatase related
UP12_17035	COG0477	Major facilitator Superfamily
UP12_17040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_17045	COG0765	amino acid transport
UP12_17050	COG1126	abc transporter atp-binding protein
UP12_17055	COG0004	ammonium transporteR
UP12_17060	COG0347	Belongs to the P(II) protein family
UP12_17065	COG0739	heme binding
UP12_17070	COG1247	-acetyltransferase
UP12_17105	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UP12_17110	COG0523	cobalamin synthesis protein
UP12_17115	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP12_17120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UP12_17125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UP12_17135	COG0243	molybdopterin cofactor binding
UP12_17140	COG2304	oxidoreductase activity
UP12_17145	COG2304	oxidoreductase activity
UP12_17150	COG2385	sporulation resulting in formation of a cellular spore
UP12_17155	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UP12_17165	COG4836	Membrane
UP12_17175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UP12_17180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UP12_17185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UP12_17190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
UP12_17195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP12_17200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UP12_17205	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP12_17210	COG0356	it plays a direct role in the translocation of protons across the membrane
UP12_17220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UP12_17225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UP12_17230	COG4475	Protein of unknown function (DUF436)
UP12_17235	COG0698	ribose 5-phosphate isomerase
UP12_17240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP12_17245	COG1971	Probably functions as a manganese efflux pump
UP12_17250	COG0009	L-threonylcarbamoyladenylate synthase
UP12_17255	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
UP12_17270	COG2890	protein-(glutamine-N5) methyltransferase activity
UP12_17275	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UP12_17280	COG0789	Transcriptional regulator
UP12_17285	COG0679	Auxin Efflux Carrier
UP12_17290	COG0281	malic enzyme
UP12_17295	COG1435	thymidine kinase activity
UP12_17300	COG0254	rRNA binding
UP12_17305	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UP12_17310	COG1494	fructose-1,6-bisphosphatase
UP12_17315	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UP12_17320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UP12_17325	COG0191	fructose-bisphosphate aldolase activity
UP12_17330	COG2204	response regulator
UP12_17335	COG4821	SIS domain
UP12_17340	COG0504	CTP synthase activity
UP12_17345	COG3343	RNA polymerase activity
UP12_17380	COG1960	acyl-CoA dehydrogenase activity
UP12_17385	COG1960	acyl-CoA dehydrogenase activity
UP12_17390	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP12_17395	COG0183	Belongs to the thiolase family
UP12_17400	COG0247	lactate metabolic process
UP12_17400	COG2181	nitrate reductase activity
UP12_17405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP12_17410	COG4294	response to UV
UP12_17420	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP12_17425	COG1132	(ABC) transporter
UP12_17430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP12_17435	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP12_17440	COG0018	arginyl-trna synthetase
UP12_17445	COG4506	Protein conserved in bacteria
UP12_17455	COG0010	Belongs to the arginase family
UP12_17460	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UP12_17465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP12_17475	COG1994	Peptidase M50
UP12_17480	COG1942	4-Oxalocrotonate Tautomerase
UP12_17490	COG3465	dGTPase activity
UP12_17495	COG1078	dGTPase activity
UP12_17500	COG4844	belongs to the
UP12_17515	COG1215	transferase activity, transferring glycosyl groups
UP12_17540	COG5444	nuclease activity
UP12_17570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UP12_17580	COG0280	phosphate acetyltransferase
UP12_17590	COG2814	Major facilitator Superfamily
UP12_17595	COG1522	sequence-specific DNA binding
UP12_17600	COG2814	Major facilitator Superfamily
UP12_17605	COG0077	Prephenate dehydratase
UP12_17610	COG1917	Cupin 2, conserved barrel domain protein
UP12_17615	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_17620	COG0151	Belongs to the GarS family
UP12_17625	COG0436	Aminotransferase
UP12_17630	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_17635	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
UP12_17640	COG1091	dTDP-4-dehydrorhamnose reductase activity
UP12_17645	COG1088	dTDP-glucose 4,6-dehydratase activity
UP12_17650	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
UP12_17655	COG3980	spore coat polysaccharide biosynthesis protein
UP12_17660	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
UP12_17665	COG2089	acid synthase
UP12_17670	COG0456	acetyltransferase
UP12_17675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UP12_17680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP12_17685	COG0463	Glycosyl transferase, family 2
UP12_17705	COG2363	Small membrane protein
UP12_17710	COG2233	PERMEase
UP12_17720	COG1012	belongs to the aldehyde dehydrogenase family
UP12_17725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UP12_17730	COG1216	Glycosyl transferase, family 2
UP12_17740	COG0351	phosphomethylpyrimidine kinase
UP12_17750	COG1621	beta-fructofuranosidase activity
UP12_17755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_17755	COG1263	PTS System
UP12_17760	COG3711	transcriptional antiterminator
UP12_17770	COG1404	Belongs to the peptidase S8 family
UP12_17780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP12_17785	COG0778	Nitroreductase
UP12_17790	COG0772	Belongs to the SEDS family
UP12_17800	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UP12_17805	COG1845	cytochrome c oxidase, subunit III
UP12_17810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
UP12_17815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UP12_17825	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
UP12_17830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UP12_17835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
UP12_17850	COG2246	polysaccharide biosynthetic process
UP12_17870	COG3162	membrane
UP12_17875	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP12_17890	COG0352	thiamine-phosphate diphosphorylase activity
UP12_17895	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
UP12_17900	COG0583	DNA-binding transcription factor activity
UP12_17905	COG1380	Effector of murein hydrolase LrgA
UP12_17910	COG1346	cytolysis
UP12_17915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UP12_17920	COG0346	lactoylglutathione lyase activity
UP12_17930	COG0765	amino acid transport
UP12_17935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP12_17940	COG0457	Tetratricopeptide repeat
UP12_17945	COG2357	RelA SpoT domain protein
UP12_17950	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP12_17955	COG1129	ABC transporter
UP12_17965	COG3420	alginic acid biosynthetic process
UP12_17970	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP12_17985	COG1486	melibiose metabolic process
UP12_17990	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP12_17995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP12_18000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP12_18005	COG3711	transcriptional antiterminator
UP12_18005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_18020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP12_18035	COG1595	DNA-templated transcription, initiation
UP12_18040	COG3866	Pectate lyase
UP12_18045	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
UP12_18050	COG4988	ABC transporter
UP12_18055	COG1294	oxidase, subunit
UP12_18060	COG1271	oxidase subunit
UP12_18080	COG4509	Sortase family
UP12_18105	COG5386	Cell surface protein
UP12_18110	COG5386	Cell surface protein
UP12_18115	COG1733	regulation of RNA biosynthetic process
UP12_18120	COG2514	catechol 2,3-dioxygenase activity
UP12_18125	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP12_18125	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP12_18130	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP12_18130	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP12_18135	COG0346	lactoylglutathione lyase activity
UP12_18140	COG0726	polysaccharide deacetylase
UP12_18145	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP12_18150	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP12_18155	COG2723	6-phospho-beta-galactosidase activity
UP12_18160	COG1312	Catalyzes the dehydration of D-mannonate
UP12_18165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP12_18170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP12_18170	COG3711	transcriptional antiterminator
UP12_18195	COG1757	Na H antiporter
UP12_18200	COG1027	Aspartate ammonia-lyase
UP12_18205	COG0252	asparaginase activity
UP12_18210	COG1396	sequence-specific DNA binding
UP12_18235	COG4842	Belongs to the WXG100 family
UP12_18240	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP12_18255	COG1737	Transcriptional regulator
UP12_18260	COG2084	Dehydrogenase
UP12_18270	COG2610	gluconate transmembrane transporter activity
UP12_18275	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UP12_18280	COG2723	6-phospho-beta-galactosidase activity
UP12_18285	COG1263	PTS System
UP12_18285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_18285	COG2190	(PTS) system
UP12_18290	COG3711	transcriptional antiterminator
UP12_18295	COG3878	Protein conserved in bacteria
UP12_18305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP12_18310	COG1122	ATPase activity
UP12_18315	COG4721	ABC-type cobalt transport system, permease component
UP12_18320	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP12_18345	COG4412	M6 family metalloprotease domain protein
UP12_18345	COG3291	Pkd domain containing protein
UP12_18350	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
UP12_18355	COG0778	Nitroreductase
UP12_18360	COG1846	Transcriptional regulator
UP12_18365	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
UP12_18370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UP12_18375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
UP12_18380	COG2390	Transcriptional regulator
UP12_18405	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
UP12_18405	COG2755	lipolytic protein G-D-S-L family
UP12_18410	COG0477	Major facilitator Superfamily
UP12_18430	COG0561	phosphatase activity
UP12_18435	COG0789	Transcriptional regulator
UP12_18440	COG0673	inositol 2-dehydrogenase activity
UP12_18445	COG0840	transmembrane signaling receptor activity
UP12_18450	COG1113	amino acid transport
UP12_18455	COG4335	DNA alkylation repair
UP12_18465	COG1070	Carbohydrate kinase
UP12_18470	COG1737	Transcriptional regulator
UP12_18505	COG0583	DNA-binding transcription factor activity
UP12_18510	COG1609	Transcriptional regulator
UP12_18515	COG2182	Extracellular solute-binding protein
UP12_18520	COG1175	transmembrane transport
UP12_18525	COG3833	ABC-type maltose transport systems, permease component
UP12_18535	COG1874	Beta-galactosidase
UP12_18540	COG2851	Citrate transporter
UP12_18550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP12_18555	COG1131	(ABC) transporter
UP12_18565	COG2824	Alkylphosphonate utilization operon protein PhnA
UP12_18570	COG1929	Belongs to the glycerate kinase type-1 family
UP12_18575	COG2610	gluconate transmembrane transporter activity
UP12_18580	COG3835	regulator
UP12_18585	COG1309	transcriptional regulator
UP12_18590	COG2814	Major facilitator Superfamily
UP12_18600	COG1136	(ABC) transporter
UP12_18610	COG0457	Tetratricopeptide repeat
UP12_18615	COG3711	transcriptional antiterminator
UP12_18620	COG2723	6-phospho-beta-galactosidase activity
UP12_18625	COG2190	(PTS) system
UP12_18625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP12_18625	COG1263	PTS System
UP12_18650	COG0494	nUDIX hydrolase
UP12_18665	COG1113	amino acid transport
UP12_18680	COG2814	Major facilitator Superfamily
UP12_18685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UP12_18690	COG2814	Major facilitator Superfamily
UP12_18715	COG2723	6-phospho-beta-galactosidase activity
UP12_18720	COG2188	Transcriptional regulator
UP12_18730	COG0384	phenazine biosynthesis protein PhzF
UP12_18735	COG0583	DNA-binding transcription factor activity
UP12_18755	COG5002	protein histidine kinase activity
UP12_18755	COG3850	Histidine kinase
UP12_18765	COG2409	Drug exporters of the RND superfamily
UP12_18775	COG2814	Major facilitator Superfamily
UP12_18780	COG0640	Transcriptional regulator
UP12_18830	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UP12_18835	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP12_18845	COG4720	Psort location CytoplasmicMembrane, score
UP12_18865	COG0456	acetyltransferase
UP12_18870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP12_18875	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UP12_18880	COG4853	Protein conserved in bacteria
UP12_18885	COG4863	YycH protein
UP12_18890	COG5002	protein histidine kinase activity
UP12_18895	COG0745	RESPONSE REGULATOR receiver
UP12_18920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP12_18930	COG2311	Membrane
UP12_18935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
UP12_18940	COG1309	transcriptional regulator
UP12_18945	COG2124	cytochrome p450
UP12_18950	COG0346	lactoylglutathione lyase activity
UP12_18955	COG0305	Participates in initiation and elongation during chromosome replication
UP12_18970	COG2819	hydrolase of the alpha beta superfamily
UP12_18975	COG1028	Short-chain dehydrogenase reductase Sdr
UP12_18980	COG1169	isochorismate synthase
UP12_18985	COG1021	2,3-dihydroxybenzoate-AMP ligase
UP12_18990	COG1535	isochorismatase
UP12_18990	COG3433	isochorismatase activity
UP12_18995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
UP12_19000	COG3251	PFAM MbtH domain protein
UP12_19005	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_19005	COG2207	Transcriptional regulator
UP12_19010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP12_19015	COG2819	hydrolase of the alpha beta superfamily
UP12_19020	COG2807	transmembrane transport
UP12_19025	COG0359	binds to the 23S rRNA
UP12_19030	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
UP12_19035	COG4241	membrane
UP12_19040	COG1227	inorganic diphosphatase activity
UP12_19050	COG1595	DNA-templated transcription, initiation
UP12_19060	COG0753	catalase activity
UP12_19065	COG0655	NAD(P)H dehydrogenase (quinone) activity
UP12_19070	COG0400	carboxylic ester hydrolase activity
UP12_19075	COG0346	lactoylglutathione lyase activity
UP12_19080	COG1174	glycine betaine transport
UP12_19085	COG1125	glycine betaine transport
UP12_19085	COG0517	IMP dehydrogenase activity
UP12_19090	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UP12_19095	COG0629	single-stranded DNA binding
UP12_19100	COG0360	Binds together with S18 to 16S ribosomal RNA
UP12_19105	COG0012	GTP binding
UP12_19110	COG4481	Protein conserved in bacteria
UP12_19125	COG3949	Membrane
UP12_19135	COG1475	DNA binding
UP12_19140	COG1192	Involved in chromosome partitioning
UP12_19150	COG1475	DNA binding
UP12_19155	COG0357	Ribosomal RNA small subunit methyltransferase G
UP12_19160	COG0445	tRNA wobble uridine modification
UP12_19165	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
UP12_19170	COG1847	R3H domain protein
UP12_19175	COG0706	membrane insertase activity
UP12_19180	COG0594	ribonuclease P activity
UP12_19300	COG0791	NLP P60 protein
UP12_19300	COG0741	lytic transglycosylase activity
UP12_19385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP12_19455	COG0629	single-stranded DNA binding
UP12_19585	COG0457	Tetratricopeptide repeat