locus-tag	class	description
VT48_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
VT48_00010	COG0592	DNA-directed DNA polymerase activity
VT48_00015	COG2501	S4 domain
VT48_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
VT48_00030	COG0187	DNA topoisomerase II activity
VT48_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VT48_00060	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
VT48_00065	COG3853	Toxic anion resistance protein (TelA)
VT48_00070	COG1982	Orn Lys Arg decarboxylase major
VT48_00075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
VT48_00080	COG3870	Protein conserved in bacteria
VT48_00085	COG1728	Protein conserved in bacteria
VT48_00090	COG0470	DNA polymerase III
VT48_00095	COG1774	PSP1 C-terminal conserved region
VT48_00100	COG4467	Involved in initiation control of chromosome replication
VT48_00105	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
VT48_00110	COG2827	Endonuclease containing a URI domain
VT48_00115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
VT48_00120	COG2002	toxin-antitoxin pair type II binding
VT48_00125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VT48_00125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VT48_00130	COG0084	hydrolase, TatD family'
VT48_00135	COG3584	3D domain protein
VT48_00135	COG3583	domain protein
VT48_00140	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
VT48_00145	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
VT48_00155	COG4466	Protein conserved in bacteria
VT48_00165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
VT48_00170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VT48_00175	COG0251	oxidation-reduction process
VT48_00180	COG2088	sporulation resulting in formation of a cellular spore
VT48_00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
VT48_00195	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
VT48_00200	COG0193	aminoacyl-tRNA hydrolase activity
VT48_00210	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
VT48_00215	COG2002	toxin-antitoxin pair type II binding
VT48_00220	COG2244	polysaccharide biosynthetic process
VT48_00225	COG3956	TIGRFAM MazG family protein
VT48_00230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
VT48_00245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
VT48_00250	COG1098	S1 RNA binding domain
VT48_00265	COG2208	phosphoserine phosphatase activity
VT48_00270	COG2304	oxidoreductase activity
VT48_00275	COG0515	serine threonine protein kinase
VT48_00280	COG0037	tRNA processing
VT48_00290	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
VT48_00295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
VT48_00300	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
VT48_00305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VT48_00310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VT48_00315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
VT48_00320	COG0512	Glutamine amidotransferase of anthranilate synthase
VT48_00325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VT48_00330	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
VT48_00335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
VT48_00340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
VT48_00345	COG1396	sequence-specific DNA binding
VT48_00350	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VT48_00355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
VT48_00375	COG4463	regulation of RNA biosynthetic process
VT48_00380	COG3880	PFAM UvrB UvrC protein
VT48_00385	COG3869	Catalyzes the specific phosphorylation of arginine residues in
VT48_00390	COG0542	response to heat
VT48_00395	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
VT48_00400	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
VT48_00405	COG4956	integral membrane protein (PIN domain superfamily)
VT48_00410	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
VT48_00415	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
VT48_00420	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
VT48_00425	COG1045	serine acetyltransferase
VT48_00430	COG0215	cysteine-tRNA ligase activity
VT48_00435	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
VT48_00440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VT48_00445	COG3688	RNA-binding protein containing a PIN domain
VT48_00450	COG1595	DNA-templated transcription, initiation
VT48_00455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VT48_00460	COG0250	Participates in transcription elongation, termination and antitermination
VT48_00465	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
VT48_00470	COG0081	regulation of translation
VT48_00475	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
VT48_00480	COG0222	ribosome binding
VT48_00485	COG2813	Specifically methylates the guanine in position
VT48_00490	COG0085	RNA polymerase activity
VT48_00495	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
VT48_00500	COG1358	cellular component organization or biogenesis
VT48_00505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
VT48_00510	COG0049	tRNA binding
VT48_00515	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
VT48_00520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
VT48_00525	COG0596	Alpha beta hydrolase
VT48_00530	COG0051	transcription antitermination factor activity, RNA binding
VT48_00535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
VT48_00540	COG0088	Forms part of the polypeptide exit tunnel
VT48_00545	COG0089	rRNA binding
VT48_00550	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
VT48_00555	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
VT48_00560	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
VT48_00565	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
VT48_00570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
VT48_00575	COG0255	Belongs to the universal ribosomal protein uL29 family
VT48_00580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
VT48_00585	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
VT48_00590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
VT48_00595	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
VT48_00600	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VT48_00605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
VT48_00610	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
VT48_00615	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
VT48_00620	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
VT48_00625	COG1841	ribosomal large subunit assembly
VT48_00630	COG0200	Binds to the 23S rRNA
VT48_00635	COG0201	protein transport
VT48_00640	COG0563	adenylate kinase activity
VT48_00645	COG0024	Methionine aminopeptidase
VT48_00650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
VT48_00655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
VT48_00660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
VT48_00665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
VT48_00670	COG0202	RNA polymerase activity
VT48_00675	COG0203	ribosomal protein L17
VT48_00680	COG1122	ATPase activity
VT48_00685	COG1122	ATPase activity
VT48_00690	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VT48_00695	COG0101	tRNA pseudouridine synthase activity
VT48_00700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
VT48_00705	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
VT48_00725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VT48_00755	COG0860	N-Acetylmuramoyl-L-alanine amidase
VT48_00760	COG0489	protein tyrosine kinase activity
VT48_00770	COG2194	sulfuric ester hydrolase activity
VT48_00775	COG0726	polysaccharide deacetylase
VT48_00805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VT48_00810	COG0659	secondary active sulfate transmembrane transporter activity
VT48_00815	COG0385	Bile acid
VT48_00820	COG3876	Protein conserved in bacteria
VT48_00825	COG1472	Belongs to the glycosyl hydrolase 3 family
VT48_00830	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
VT48_00835	COG1263	PTS System
VT48_00835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_00840	COG1737	Transcriptional regulator
VT48_00845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
VT48_00880	COG1595	DNA-templated transcription, initiation
VT48_00885	COG5662	AntiSigma factor
VT48_00890	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
VT48_00895	COG4856	YbbR-like protein
VT48_00900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VT48_00905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
VT48_00920	COG1131	(ABC) transporter
VT48_00930	COG0577	efflux transmembrane transporter activity
VT48_00930	COG1136	(ABC) transporter
VT48_00940	COG1695	Transcriptional regulator
VT48_00950	COG1131	(ABC) transporter
VT48_00960	COG1413	lyase activity
VT48_00965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_00985	COG1131	(ABC) transporter
VT48_01030	COG2311	Membrane
VT48_01050	COG1476	TRANSCRIPTIONal
VT48_01060	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
VT48_01065	COG2207	Transcriptional regulator
VT48_01070	COG1309	transcriptional regulator
VT48_01085	COG1113	amino acid transport
VT48_01090	COG0584	glycerophosphoryl diester phosphodiesterase
VT48_01095	COG2271	Major facilitator Superfamily
VT48_01105	COG1331	Highly conserved protein containing a thioredoxin domain
VT48_01110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VT48_01125	COG0640	Transcriptional regulator
VT48_01140	COG1937	Protein conserved in bacteria
VT48_01145	COG2210	Belongs to the sulfur carrier protein TusA family
VT48_01155	COG0425	Belongs to the sulfur carrier protein TusA family
VT48_01155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VT48_01160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VT48_01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VT48_01165	COG0425	Belongs to the sulfur carrier protein TusA family
VT48_01170	COG0730	response to heat
VT48_01175	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VT48_01180	COG2814	Major facilitator Superfamily
VT48_01195	COG1846	Transcriptional regulator
VT48_01205	COG1683	Conserved Protein
VT48_01215	COG0656	L-ascorbic acid biosynthetic process
VT48_01220	COG0371	Dehydrogenase
VT48_01230	COG0531	amino acid
VT48_01240	COG3711	transcriptional antiterminator
VT48_01245	COG1263	PTS System
VT48_01245	COG2190	(PTS) system
VT48_01245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_01250	COG2723	6-phospho-beta-galactosidase activity
VT48_01265	COG3711	transcriptional antiterminator
VT48_01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_01270	COG1940	carbohydrate kinase activity
VT48_01275	COG0383	alpha-mannosidase activity
VT48_01280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_01285	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_01290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_01290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_01295	COG1404	Belongs to the peptidase S8 family
VT48_01310	COG0833	amino acid
VT48_01315	COG2040	homocysteine
VT48_01320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VT48_01335	COG2814	Major facilitator Superfamily
VT48_01355	COG1404	Belongs to the peptidase S8 family
VT48_01365	COG1309	transcriptional regulator
VT48_01370	COG1917	Cupin 2, conserved barrel domain protein
VT48_01375	COG1063	alcohol dehydrogenase
VT48_01380	COG1846	Transcriptional regulator
VT48_01385	COG0318	PFAM AMP-dependent synthetase and ligase
VT48_01390	COG0531	amino acid
VT48_01400	COG0596	Alpha beta hydrolase
VT48_01405	COG1115	amino acid carrier protein
VT48_01410	COG2066	Belongs to the glutaminase family
VT48_01415	COG4191	Histidine kinase
VT48_01420	COG0784	Response regulator, receiver
VT48_01425	COG1405	negative regulation of cell septum assembly
VT48_01425	COG3012	SEC-C Motif Domain Protein
VT48_01435	COG0667	Aldo Keto reductase
VT48_01440	COG3290	protein histidine kinase activity
VT48_01445	COG3279	Response regulator of the LytR AlgR family
VT48_01450	COG4555	ABC transporter
VT48_01455	COG1668	transmembrane transport
VT48_01470	COG1404	Belongs to the peptidase S8 family
VT48_01480	COG3773	Cell wall hydrolase
VT48_01485	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_01495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VT48_01500	COG2310	stress, protein
VT48_01505	COG2310	stress, protein
VT48_01510	COG2310	stress, protein
VT48_01515	COG0861	Integral membrane protein TerC family
VT48_01545	COG3853	Toxic anion resistance protein (TelA)
VT48_01550	COG4175	Glycine betaine
VT48_01550	COG0517	IMP dehydrogenase activity
VT48_01555	COG4176	ABC-type proline glycine betaine transport system permease component
VT48_01560	COG2113	Glycine betaine
VT48_01575	COG1473	amidohydrolase
VT48_01580	COG1288	antiporter activity
VT48_01585	COG0039	L-malate dehydrogenase activity
VT48_01590	COG1620	l-lactate permease
VT48_01595	COG1609	Transcriptional regulator
VT48_01600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VT48_01605	COG0561	phosphatase activity
VT48_01610	COG0673	inositol 2-dehydrogenase activity
VT48_01615	COG0738	Major facilitator superfamily
VT48_01620	COG1280	lysine exporter protein (LysE YggA)
VT48_01635	COG3403	YqcI/YcgG family
VT48_01640	COG1113	amino acid transport
VT48_01645	COG3665	Urea carboxylase-associated protein
VT48_01650	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
VT48_01675	COG1012	belongs to the aldehyde dehydrogenase family
VT48_01680	COG0710	3-dehydroquinate dehydratase activity
VT48_01685	COG0028	Belongs to the TPP enzyme family
VT48_01695	COG1804	L-carnitine dehydratase bile acid-inducible protein F
VT48_01700	COG2271	Major facilitator Superfamily
VT48_01710	COG1414	Transcriptional regulator
VT48_01715	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
VT48_01720	COG2226	methyltransferase
VT48_01725	COG0583	DNA-binding transcription factor activity
VT48_01730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VT48_01735	COG3458	cephalosporin-C deacetylase activity
VT48_01745	COG3541	Predicted nucleotidyltransferase
VT48_01750	COG0506	proline dehydrogenase activity
VT48_01755	COG1012	belongs to the aldehyde dehydrogenase family
VT48_01760	COG2508	Transcriptional regulator
VT48_01765	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VT48_01770	COG0765	amino acid transport
VT48_01775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_01785	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VT48_01790	COG1522	sequence-specific DNA binding
VT48_01795	COG2746	aminoglycoside 3-N-acetyltransferase activity
VT48_01805	COG0840	transmembrane signaling receptor activity
VT48_01805	COG3290	protein histidine kinase activity
VT48_01810	COG3209	COG3209 Rhs family protein
VT48_01835	COG3842	ATPase activity
VT48_01840	COG1176	ABC-type spermidine putrescine transport system, permease component I
VT48_01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VT48_01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VT48_01860	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VT48_01875	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
VT48_01890	COG4555	ABC transporter
VT48_01905	COG0697	spore germination
VT48_01910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VT48_01920	COG2207	Transcriptional regulator
VT48_01920	COG3708	Transcriptional regulator
VT48_01930	COG2364	Membrane
VT48_01935	COG1126	abc transporter atp-binding protein
VT48_01940	COG0765	amino acid transport
VT48_01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_01950	COG0412	Dienelactone hydrolase
VT48_01955	COG0833	amino acid
VT48_01960	COG3104	oligopeptide transport
VT48_01965	COG5434	Belongs to the glycosyl hydrolase 28 family
VT48_01980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_01985	COG0765	amino acid transport
VT48_01990	COG1126	abc transporter atp-binding protein
VT48_02000	COG2079	MmgE PrpD family protein
VT48_02015	COG0745	RESPONSE REGULATOR receiver
VT48_02020	COG5002	protein histidine kinase activity
VT48_02020	COG3850	Histidine kinase
VT48_02025	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_02030	COG0527	aspartate kinase activity
VT48_02035	COG2814	Major facilitator Superfamily
VT48_02040	COG1309	transcriptional regulator
VT48_02050	COG0640	Transcriptional regulator
VT48_02060	COG0583	DNA-binding transcription factor activity
VT48_02065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VT48_02070	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
VT48_02075	COG0531	amino acid
VT48_02080	COG1012	belongs to the aldehyde dehydrogenase family
VT48_02085	COG2249	NAD(P)H dehydrogenase (quinone) activity
VT48_02090	COG4549	nuclear export factor GLE1
VT48_02095	COG1276	copper resistance
VT48_02095	COG2372	response to copper ion
VT48_02100	COG2213	PTS system mannitol-specific
VT48_02105	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_02110	COG0246	Mannitol dehydrogenase
VT48_02115	COG0840	transmembrane signaling receptor activity
VT48_02150	COG0346	lactoylglutathione lyase activity
VT48_02160	COG0561	phosphatase activity
VT48_02165	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
VT48_02170	COG1914	H( )-stimulated, divalent metal cation uptake system
VT48_02175	COG4336	lyase activity
VT48_02180	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
VT48_02185	COG1984	allophanate hydrolase subunit 2
VT48_02190	COG1414	Transcriptional regulator
VT48_02195	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VT48_02200	COG2755	lipolytic protein G-D-S-L family
VT48_02210	COG3711	transcriptional antiterminator
VT48_02215	COG2226	methyltransferase
VT48_02220	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_02225	COG3871	stress protein (general stress protein 26)
VT48_02245	COG2814	Major facilitator Superfamily
VT48_02250	COG1802	Transcriptional regulator
VT48_02255	COG2207	Transcriptional regulator
VT48_02255	COG1917	Cupin 2, conserved barrel domain protein
VT48_02260	COG0697	spore germination
VT48_02265	COG0473	3-isopropylmalate dehydrogenase activity
VT48_02270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VT48_02270	COG0551	DNA topoisomerase type I activity
VT48_02275	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
VT48_02280	COG3706	GGDEF domain
VT48_02285	COG5298	Protein conserved in bacteria
VT48_02290	COG1215	transferase activity, transferring glycosyl groups
VT48_02300	COG0531	amino acid
VT48_02305	COG0028	Belongs to the TPP enzyme family
VT48_02310	COG5444	nuclease activity
VT48_02340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VT48_02345	COG1914	H( )-stimulated, divalent metal cation uptake system
VT48_02350	COG2261	transglycosylase associated protein
VT48_02355	COG2217	Heavy metal translocating P-type atpase
VT48_02360	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
VT48_02365	COG3290	protein histidine kinase activity
VT48_02370	COG4565	transcriptional regulatory protein
VT48_02375	COG1301	dicarboxylic acid transport
VT48_02380	COG0628	permease
VT48_02385	COG1301	dicarboxylic acid transport
VT48_02390	COG1131	(ABC) transporter
VT48_02395	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
VT48_02405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_02410	COG1181	Belongs to the D-alanine--D-alanine ligase family
VT48_02415	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
VT48_02430	COG0513	Belongs to the DEAD box helicase family
VT48_02435	COG3402	PFAM membrane-flanked domain
VT48_02440	COG3428	Bacterial PH domain
VT48_02445	COG0705	Rhomboid family
VT48_02450	COG0736	holo-[acyl-carrier-protein] synthase activity
VT48_02455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
VT48_02460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VT48_02465	COG0864	Transcriptional regulator
VT48_02470	COG2337	Toxic component of a toxin-antitoxin (TA) module
VT48_02475	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_02480	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_02485	COG2172	sigma factor antagonist activity
VT48_02490	COG2208	phosphoserine phosphatase activity
VT48_02495	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_02500	COG2172	sigma factor antagonist activity
VT48_02505	COG1191	sigma factor activity
VT48_02510	COG2208	phosphoserine phosphatase activity
VT48_02515	COG2183	response to ionizing radiation
VT48_02520	COG3091	SprT-like family
VT48_02525	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VT48_02530	COG0022	dehydrogenase e1 component
VT48_02535	COG0508	dehydrogenase complex catalyzes the overall conversion of
VT48_02540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VT48_02545	COG3284	Transcriptional regulator
VT48_02590	COG1278	Cold shock
VT48_02595	COG1263	PTS System
VT48_02595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_02595	COG2190	(PTS) system
VT48_02600	COG3394	polysaccharide catabolic process
VT48_02605	COG3711	transcriptional antiterminator
VT48_02610	COG1064	alcohol dehydrogenase
VT48_02615	COG0789	Transcriptional regulator
VT48_02635	COG0477	Major facilitator Superfamily
VT48_02650	COG4221	oxidoreductase activity
VT48_02660	COG0252	asparaginase activity
VT48_02680	COG2814	Major facilitator Superfamily
VT48_02725	COG1309	transcriptional regulator
VT48_02730	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VT48_02735	COG1846	Transcriptional regulator
VT48_02740	COG0778	Nitroreductase
VT48_02755	COG1396	sequence-specific DNA binding
VT48_02765	COG0456	acetyltransferase
VT48_02775	COG4122	O-methyltransferase activity
VT48_02785	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
VT48_02790	COG0697	spore germination
VT48_02800	COG1301	dicarboxylic acid transport
VT48_02845	COG0517	IMP dehydrogenase activity
VT48_02845	COG0516	GMP reductase activity
VT48_02850	COG1686	Belongs to the peptidase S11 family
VT48_02855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VT48_02860	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
VT48_02865	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
VT48_02870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
VT48_02875	COG0840	transmembrane signaling receptor activity
VT48_02885	COG1428	Deoxynucleoside kinase
VT48_02890	COG1428	Deoxynucleoside kinase
VT48_02895	COG1388	LysM domain
VT48_02895	COG3858	chitin binding
VT48_02900	COG1335	isochorismatase
VT48_02905	COG0590	tRNA wobble adenosine to inosine editing
VT48_02910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
VT48_02915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
VT48_02920	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
VT48_02960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
VT48_02965	COG0802	atpase or kinase
VT48_02970	COG1214	PFAM Peptidase M22, glycoprotease
VT48_02975	COG0456	acetyltransferase
VT48_02980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
VT48_02985	COG0488	(ABC) transporter
VT48_02990	COG0315	cyclic pyranopterin monophosphate synthase activity
VT48_02995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
VT48_03000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
VT48_03005	COG0805	protein transport
VT48_03020	COG1266	CAAX protease self-immunity
VT48_03025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
VT48_03030	COG0459	protein refolding
VT48_03035	COG1846	Transcriptional regulator
VT48_03040	COG2808	Putative FMN-binding domain
VT48_03045	COG1876	peptidase activity
VT48_03070	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
VT48_03075	COG0823	Involved in the tonB-independent uptake of proteins
VT48_03085	COG2132	Multicopper oxidase
VT48_03090	COG1113	amino acid transport
VT48_03095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VT48_03100	COG0714	Associated with various cellular activities
VT48_03105	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
VT48_03110	COG1305	Transglutaminase-like
VT48_03115	COG0519	Catalyzes the synthesis of GMP from XMP
VT48_03115	COG0518	GMP synthase (glutamine-hydrolyzing) activity
VT48_03125	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
VT48_03135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VT48_03165	COG1595	DNA-templated transcription, initiation
VT48_03175	COG2814	Major facilitator Superfamily
VT48_03180	COG0583	DNA-binding transcription factor activity
VT48_03185	COG2252	PERMEase
VT48_03190	COG5583	Uncharacterized small protein (DUF2292)
VT48_03195	COG3064	Membrane
VT48_03200	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
VT48_03210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
VT48_03215	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
VT48_03220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
VT48_03225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
VT48_03230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VT48_03235	COG0047	phosphoribosylformylglycinamidine synthase activity
VT48_03240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
VT48_03245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
VT48_03250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
VT48_03255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
VT48_03260	COG0138	bifunctional purine biosynthesis protein purh
VT48_03265	COG0151	Belongs to the GarS family
VT48_03285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VT48_03290	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
VT48_03295	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
VT48_03300	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VT48_03310	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
VT48_03315	COG4496	protein, YerC YecD
VT48_03325	COG0069	glutamate synthase activity
VT48_03340	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
VT48_03345	COG0210	DNA helicase
VT48_03350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
VT48_03355	COG4851	CamS sex pheromone cAM373 precursor
VT48_03365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VT48_03370	COG1285	pathogenesis
VT48_03375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VT48_03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VT48_03385	COG0154	amidase activity
VT48_03390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
VT48_03395	COG1309	transcriptional regulator
VT48_03400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VT48_03405	COG1957	nucleoside hydrolase
VT48_03410	COG1597	lipid kinase activity
VT48_03415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VT48_03420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
VT48_03435	COG1959	2 iron, 2 sulfur cluster binding
VT48_03440	COG0492	ferredoxin-NADP+ reductase activity
VT48_03455	COG1486	melibiose metabolic process
VT48_03465	COG2211	Major facilitator Superfamily
VT48_03490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
VT48_03495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VT48_03500	COG1442	glycosyl transferase family 8
VT48_03505	COG1216	Glycosyl transferase, family 2
VT48_03510	COG1442	glycosyl transferase family 8
VT48_03515	COG2223	nitrite transmembrane transporter activity
VT48_03525	COG0471	metal ion transport
VT48_03540	COG0071	Belongs to the small heat shock protein (HSP20) family
VT48_03555	COG0531	amino acid
VT48_03560	COG0457	Tetratricopeptide repeat
VT48_03560	COG0463	Glycosyl transferase, family 2
VT48_03565	COG0488	(ABC) transporter
VT48_03570	COG1469	GTP cyclohydrolase I activity
VT48_03575	COG0789	Transcriptional regulator
VT48_03580	COG2814	Major facilitator Superfamily
VT48_03585	COG0488	(ABC) transporter
VT48_03590	COG0513	Belongs to the DEAD box helicase family
VT48_03595	COG2130	NADP-dependent
VT48_03615	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VT48_03615	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VT48_03620	COG1262	PFAM Formylglycine-generating sulfatase enzyme
VT48_03630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VT48_03630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VT48_03660	COG3290	protein histidine kinase activity
VT48_03665	COG4565	transcriptional regulatory protein
VT48_03670	COG3181	Tripartite tricarboxylate transporter family receptor
VT48_03675	COG2851	Citrate transporter
VT48_03685	COG3479	Phenolic acid decarboxylase
VT48_03690	COG1695	Transcriptional regulator
VT48_03695	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
VT48_03705	COG1254	Belongs to the acylphosphatase family
VT48_03710	COG2258	MOSC domain
VT48_03715	COG0024	Methionine aminopeptidase
VT48_03720	COG1263	PTS System
VT48_03720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_03725	COG3739	integral membrane protein
VT48_03740	COG1368	sulfuric ester hydrolase activity
VT48_03745	COG0076	glutamate decarboxylase activity
VT48_03750	COG0840	transmembrane signaling receptor activity
VT48_03760	COG1263	PTS System
VT48_03760	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_03765	COG0366	Alpha amylase catalytic
VT48_03770	COG2188	Transcriptional regulator
VT48_03780	COG0737	Belongs to the 5'-nucleotidase family
VT48_03785	COG0693	protein deglycase activity
VT48_03790	COG4840	Belongs to the UPF0435 family
VT48_03795	COG1115	amino acid carrier protein
VT48_03805	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VT48_03810	COG4980	gas vesicle protein
VT48_03815	COG1295	ribonuclease BN
VT48_03820	COG0477	Major facilitator Superfamily
VT48_03830	COG0387	Pfam Sodium calcium exchanger
VT48_03840	COG0217	transcriptional regulatory protein
VT48_03850	COG0668	transmembrane transport
VT48_03855	COG0535	radical SAM domain protein
VT48_03865	COG0726	polysaccharide deacetylase
VT48_03875	COG0598	Magnesium transport protein CorA
VT48_03885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
VT48_03890	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
VT48_03910	COG0789	Transcriptional regulator
VT48_03915	COG2814	Major facilitator Superfamily
VT48_03930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VT48_03980	COG2076	Multidrug Resistance protein
VT48_03985	COG2076	Multidrug Resistance protein
VT48_03990	COG1309	transcriptional regulator
VT48_04000	COG4637	Psort location Cytoplasmic, score
VT48_04005	COG2755	lipolytic protein G-D-S-L family
VT48_04010	COG0492	ferredoxin-NADP+ reductase activity
VT48_04015	COG2169	Transcriptional regulator
VT48_04020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VT48_04025	COG1132	(ABC) transporter
VT48_04030	COG1742	UPF0060 membrane protein
VT48_04035	COG1595	DNA-templated transcription, initiation
VT48_04055	COG2318	DinB family
VT48_04065	COG1846	Transcriptional regulator
VT48_04070	COG0392	lysyltransferase activity
VT48_04070	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
VT48_04090	COG0778	Nitroreductase
VT48_04100	COG1090	epimerase
VT48_04105	COG2137	regulation of response to DNA damage stimulus
VT48_04125	COG0463	Glycosyl transferase, family 2
VT48_04130	COG4485	Bacterial membrane protein, YfhO
VT48_04135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
VT48_04150	COG2140	Oxalate decarboxylase
VT48_04155	COG1191	sigma factor activity
VT48_04165	COG1988	membrane-bound metal-dependent
VT48_04170	COG1194	a g-specific adenine glycosylase
VT48_04180	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_04195	COG3557	Belongs to the UPF0374 family
VT48_04200	COG1132	(ABC) transporter
VT48_04205	COG0444	Belongs to the ABC transporter superfamily
VT48_04210	COG4608	Belongs to the ABC transporter superfamily
VT48_04215	COG0747	negative chemotaxis
VT48_04230	COG4129	membrane
VT48_04235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VT48_04240	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VT48_04245	COG0735	belongs to the Fur family
VT48_04400	COG1368	sulfuric ester hydrolase activity
VT48_04405	COG0681	Belongs to the peptidase S26 family
VT48_04420	COG1116	anion transmembrane transporter activity
VT48_04425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VT48_04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VT48_04435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VT48_04450	COG1131	(ABC) transporter
VT48_04480	COG3382	B3 4 domain protein
VT48_04485	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
VT48_04495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
VT48_04500	COG2766	serine protein kinase
VT48_04505	COG2718	Belongs to the UPF0229 family
VT48_04510	COG1566	PFAM secretion protein HlyD family protein
VT48_04515	COG2814	Major facilitator Superfamily
VT48_04520	COG0655	NAD(P)H dehydrogenase (quinone) activity
VT48_04530	COG1278	Cold shock
VT48_04535	COG3706	GGDEF domain
VT48_04560	COG5577	PFAM Coat F domain
VT48_04565	COG5002	protein histidine kinase activity
VT48_04570	COG0737	Belongs to the 5'-nucleotidase family
VT48_04570	COG1525	nuclease
VT48_04570	COG4085	toxin activity
VT48_04575	COG3764	Sortase (surface protein transpeptidase)
VT48_04580	COG0564	pseudouridine synthase activity
VT48_04590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
VT48_04595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
VT48_04595	COG3153	acetyltransferase
VT48_04615	COG3835	regulator
VT48_04620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
VT48_04625	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
VT48_04630	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
VT48_04635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
VT48_04640	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
VT48_04645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
VT48_04650	COG2203	Gaf domain
VT48_04650	COG4585	Histidine kinase
VT48_04655	COG2197	response regulator
VT48_04670	COG0753	catalase activity
VT48_04675	COG1959	2 iron, 2 sulfur cluster binding
VT48_04680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
VT48_04680	COG1017	nitric oxide dioxygenase activity
VT48_04685	COG2719	SpoVR family
VT48_04690	COG1785	Belongs to the alkaline phosphatase family
VT48_04695	COG0791	NLP P60 protein
VT48_04695	COG1388	LysM domain
VT48_04700	COG0531	amino acid
VT48_04715	COG1595	DNA-templated transcription, initiation
VT48_04720	COG0204	Acyl-transferase
VT48_04725	COG1253	flavin adenine dinucleotide binding
VT48_04730	COG0789	Transcriptional regulator
VT48_04735	COG1253	flavin adenine dinucleotide binding
VT48_04750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
VT48_04755	COG0584	glycerophosphoryl diester phosphodiesterase
VT48_04760	COG0668	transmembrane transport
VT48_04765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
VT48_04770	COG0726	polysaccharide deacetylase
VT48_04775	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VT48_04780	COG0589	response to stress
VT48_04785	COG1132	(ABC) transporter
VT48_04790	COG1132	(ABC) transporter
VT48_04795	COG0702	epimerase
VT48_04805	COG3842	ATPase activity
VT48_04810	COG2508	Transcriptional regulator
VT48_04820	COG0189	ligase activity
VT48_04825	COG0189	ligase activity
VT48_04830	COG4399	Belongs to the UPF0754 family
VT48_04835	COG3679	Belongs to the UPF0342 family
VT48_04840	COG0561	phosphatase activity
VT48_04845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VT48_04855	COG0475	glutathione-regulated potassium exporter activity
VT48_04860	COG0490	domain, Protein
VT48_04870	COG1024	Enoyl-CoA hydratase
VT48_04880	COG0420	3'-5' exonuclease activity
VT48_04885	COG4717	serine-type aminopeptidase activity
VT48_04890	COG3481	metal-dependent phosphohydrolase, HD sub domain
VT48_04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
VT48_04925	COG1846	Transcriptional regulator
VT48_04930	COG4980	gas vesicle protein
VT48_04945	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
VT48_04950	COG0537	adenosine 5'-monophosphoramidase activity
VT48_04955	COG1131	(ABC) transporter
VT48_04960	COG4473	ABC transporter
VT48_04970	COG1473	amidohydrolase
VT48_04980	COG2329	Antibiotic biosynthesis monooxygenase
VT48_04985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VT48_04990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
VT48_05005	COG1309	transcriptional regulator
VT48_05010	COG1511	domain protein
VT48_05015	COG1363	Peptidase, m42
VT48_05020	COG1301	dicarboxylic acid transport
VT48_05025	COG1234	tRNA 3'-trailer cleavage
VT48_05030	COG0095	Lipoate-protein ligase
VT48_05035	COG0318	PFAM AMP-dependent synthetase and ligase
VT48_05045	COG0501	Belongs to the peptidase M48B family
VT48_05050	COG1404	Belongs to the peptidase S8 family
VT48_05055	COG0406	alpha-ribazole phosphatase activity
VT48_05060	COG0840	transmembrane signaling receptor activity
VT48_05065	COG0723	plastoquinol--plastocyanin reductase activity
VT48_05065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
VT48_05070	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_05080	COG4903	ComK protein
VT48_05095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VT48_05100	COG2814	Major facilitator Superfamily
VT48_05105	COG2732	(Barnase) inhibitor
VT48_05110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_05115	COG4605	iron ion homeostasis
VT48_05120	COG4604	ABC transporter, ATP-binding protein
VT48_05125	COG4607	ABC-type enterochelin transport system periplasmic component
VT48_05130	COG1316	TRANSCRIPTIONal
VT48_05145	COG0398	Pfam SNARE associated Golgi protein
VT48_05150	COG0681	Belongs to the peptidase S26 family
VT48_05155	COG3180	Ammonia monooxygenase
VT48_05170	COG2259	Doxx family
VT48_05175	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
VT48_05180	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
VT48_05185	COG1074	ATP-dependent DNA helicase activity
VT48_05190	COG0420	3'-5' exonuclease activity
VT48_05195	COG0419	ATPase involved in DNA repair
VT48_05200	COG1403	HNH endonuclease
VT48_05240	COG5337	Spore coat protein CotH
VT48_05255	COG0179	Fumarylacetoacetate (FAA) hydrolase
VT48_05270	COG0367	asparagine synthase
VT48_05285	COG1562	ergosterol biosynthetic process
VT48_05290	COG0534	Mate efflux family protein
VT48_05295	COG1917	Cupin 2, conserved barrel domain protein
VT48_05295	COG2207	Transcriptional regulator
VT48_05320	COG0076	glutamate decarboxylase activity
VT48_05355	COG1410	methionine synthase
VT48_05355	COG0646	methionine synthase
VT48_05360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
VT48_05360	COG0646	methionine synthase
VT48_05365	COG1666	GTP binding
VT48_05370	COG2996	Protein conserved in bacteria
VT48_05380	COG0840	transmembrane signaling receptor activity
VT48_05385	COG1307	EDD domain protein, DegV family
VT48_05390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VT48_05410	COG0561	phosphatase activity
VT48_05415	COG1073	alpha beta
VT48_05420	COG2151	metal-sulfur cluster biosynthetic enzyme
VT48_05425	COG0277	FAD linked oxidase domain protein
VT48_05430	COG2271	Major facilitator Superfamily
VT48_05435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
VT48_05445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
VT48_05450	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VT48_05455	COG0505	Belongs to the CarA family
VT48_05460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VT48_05465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
VT48_05475	COG2814	Major facilitator Superfamily
VT48_05485	COG2267	carboxylic ester hydrolase activity
VT48_05495	COG1744	ABC transporter substrate-binding protein PnrA-like
VT48_05510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VT48_05515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
VT48_05520	COG5504	Zn-dependent protease
VT48_05525	COG0444	Belongs to the ABC transporter superfamily
VT48_05530	COG4608	Belongs to the ABC transporter superfamily
VT48_05540	COG0601	transmembrane transport
VT48_05545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VT48_05555	COG0180	Tryptophanyl-tRNA synthetase
VT48_05560	COG4166	transmembrane transport
VT48_05565	COG0601	transmembrane transport
VT48_05570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VT48_05575	COG0444	Belongs to the ABC transporter superfamily
VT48_05580	COG4608	Belongs to the ABC transporter superfamily
VT48_05590	COG0456	acetyltransferase
VT48_05595	COG1393	Belongs to the ArsC family
VT48_05600	COG0861	Integral membrane protein TerC family
VT48_05605	COG4862	establishment of competence for transformation
VT48_05610	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VT48_05620	COG1164	Oligoendopeptidase f
VT48_05635	COG2346	COG2346, Truncated hemoglobins
VT48_05640	COG0741	lytic transglycosylase activity
VT48_05645	COG4116	CYTH
VT48_05655	COG2357	RelA SpoT domain protein
VT48_05660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VT48_05665	COG0564	pseudouridine synthase activity
VT48_05670	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
VT48_05675	COG0569	domain protein
VT48_05675	COG0475	glutathione-regulated potassium exporter activity
VT48_05680	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VT48_05685	COG0352	thiamine-phosphate diphosphorylase activity
VT48_05695	COG2104	thiamine diphosphate biosynthetic process
VT48_05700	COG2022	thiamine diphosphate biosynthetic process
VT48_05705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VT48_05710	COG0351	phosphomethylpyrimidine kinase
VT48_05715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
VT48_05770	COG0210	DNA helicase
VT48_05780	COG2153	protein acetylation
VT48_05785	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
VT48_05790	COG2382	esterase
VT48_05795	COG0626	cystathionine gamma-synthase activity
VT48_05800	COG0626	cystathionine gamma-synthase activity
VT48_05810	COG0582	viral genome integration into host DNA
VT48_05815	COG2856	Zn peptidase
VT48_05825	COG1396	sequence-specific DNA binding
VT48_05885	COG0305	Participates in initiation and elongation during chromosome replication
VT48_05895	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
VT48_05960	COG5484	DNA packaging
VT48_05965	COG1783	phage Terminase large subunit
VT48_05970	COG5518	Phage portal protein
VT48_05975	COG2369	cell adhesion
VT48_05985	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VT48_05990	COG4653	Phage capsid family
VT48_06040	COG3953	SLT domain
VT48_06040	COG5280	Phage tail tape measure protein TP901
VT48_06040	COG3953	SLT domain
VT48_06040	COG5280	Phage tail tape measure protein TP901
VT48_06045	COG1652	LysM domain
VT48_06050	COG4193	domain, Protein
VT48_06060	COG3628	GPW Gp25 family protein
VT48_06065	COG3299	homolog of phage Mu protein gp47
VT48_06070	COG3778	Protein conserved in bacteria
VT48_06105	COG3409	Peptidoglycan-binding domain 1 protein
VT48_06105	COG5632	N-Acetylmuramoyl-L-alanine amidase
VT48_06120	COG1192	Involved in chromosome partitioning
VT48_06155	COG0825	malonyl-CoA metabolic process
VT48_06170	COG0457	Tetratricopeptide repeat
VT48_06175	COG2153	protein acetylation
VT48_06180	COG2364	Membrane
VT48_06190	COG0457	Tetratricopeptide repeat
VT48_06210	COG3173	Aminoglycoside phosphotransferase
VT48_06215	COG0583	DNA-binding transcription factor activity
VT48_06235	COG0583	DNA-binding transcription factor activity
VT48_06240	COG2807	transmembrane transport
VT48_06265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
VT48_06285	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VT48_06290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VT48_06295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VT48_06300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VT48_06320	COG4195	phage-related replication protein
VT48_06325	COG2856	Zn peptidase
VT48_06330	COG5632	N-Acetylmuramoyl-L-alanine amidase
VT48_06330	COG3409	Peptidoglycan-binding domain 1 protein
VT48_06345	COG0306	phosphate transporter
VT48_06350	COG1392	Phosphate transport regulator
VT48_06360	COG0405	Gamma-glutamyltransferase
VT48_06365	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
VT48_06375	COG4208	sulfate ABC transporter
VT48_06390	COG3775	system Galactitol-specific IIC component
VT48_06405	COG1063	alcohol dehydrogenase
VT48_06410	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VT48_06415	COG0022	dehydrogenase e1 component
VT48_06415	COG0508	dehydrogenase complex catalyzes the overall conversion of
VT48_06420	COG0508	dehydrogenase complex catalyzes the overall conversion of
VT48_06425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VT48_06430	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_06435	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_06440	COG2390	Transcriptional regulator
VT48_06450	COG0531	amino acid
VT48_06455	COG0346	lactoylglutathione lyase activity
VT48_06460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VT48_06465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VT48_06470	COG2362	D-Aminopeptidase
VT48_06475	COG0601	transmembrane transport
VT48_06480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VT48_06485	COG0444	Belongs to the ABC transporter superfamily
VT48_06490	COG4166	transmembrane transport
VT48_06500	COG1619	proteins homologs of microcin C7 resistance protein MccF
VT48_06505	COG4948	Mandelate Racemase Muconate Lactonizing
VT48_06510	COG0791	NLP P60 protein
VT48_06515	COG4608	Belongs to the ABC transporter superfamily
VT48_06520	COG1834	amidinotransferase
VT48_06525	COG1607	acyl-coa hydrolase
VT48_06530	COG1695	Transcriptional regulator
VT48_06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VT48_06555	COG2076	Multidrug Resistance protein
VT48_06560	COG2076	Multidrug Resistance protein
VT48_06570	COG0788	formyltetrahydrofolate deformylase activity
VT48_06575	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VT48_06580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VT48_06585	COG0457	Tetratricopeptide repeat
VT48_06595	COG1764	response to oxidative stress
VT48_06600	COG1846	Transcriptional regulator
VT48_06605	COG1764	response to oxidative stress
VT48_06610	COG0590	tRNA wobble adenosine to inosine editing
VT48_06615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VT48_06620	COG1404	Belongs to the peptidase S8 family
VT48_06635	COG0745	RESPONSE REGULATOR receiver
VT48_06640	COG5002	protein histidine kinase activity
VT48_06640	COG3850	Histidine kinase
VT48_06645	COG3212	peptidase
VT48_06650	COG3212	peptidase
VT48_06660	COG2239	Acts as a magnesium transporter
VT48_06670	COG0583	DNA-binding transcription factor activity
VT48_06680	COG0789	Transcriptional regulator
VT48_06695	COG1846	Transcriptional regulator
VT48_06700	COG5001	Diguanylate cyclase
VT48_06700	COG3300	MHYT domain
VT48_06705	COG0586	Pfam SNARE associated Golgi protein
VT48_06710	COG0861	Integral membrane protein TerC family
VT48_06715	COG1191	sigma factor activity
VT48_06735	COG0501	Belongs to the peptidase M48B family
VT48_06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
VT48_06745	COG2323	membrane
VT48_06755	COG3594	Acyltransferase
VT48_06760	COG5002	protein histidine kinase activity
VT48_06765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
VT48_06770	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
VT48_06775	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
VT48_06780	COG0436	Aminotransferase
VT48_06785	COG1850	ribulose-bisphosphate carboxylase activity
VT48_06790	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
VT48_06795	COG0235	Class ii aldolase
VT48_06800	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
VT48_06810	COG3852	Histidine kinase
VT48_06815	COG1846	Transcriptional regulator
VT48_06820	COG1360	Flagellar Motor Protein
VT48_06825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
VT48_06830	COG0542	response to heat
VT48_06835	COG3949	Membrane
VT48_06840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
VT48_06845	COG0720	synthase
VT48_06850	COG0602	queuosine metabolic process
VT48_06855	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
VT48_06870	COG4873	Protein conserved in bacteria
VT48_06880	COG3773	Cell wall hydrolase
VT48_06885	COG2244	polysaccharide biosynthetic process
VT48_06890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_06895	COG2217	Heavy metal translocating P-type atpase
VT48_06900	COG0006	proline dipeptidase activity
VT48_06905	COG1609	Transcriptional regulator
VT48_06910	COG3711	transcriptional antiterminator
VT48_06915	COG2190	(PTS) system
VT48_06915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_06915	COG1263	PTS System
VT48_06920	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_06925	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
VT48_06935	COG1533	DNA photolyase activity
VT48_06940	COG0840	transmembrane signaling receptor activity
VT48_06950	COG2084	Dehydrogenase
VT48_06955	COG2340	Cysteine-rich secretory protein family
VT48_06960	COG0768	penicillin binding
VT48_06965	COG4191	Histidine kinase
VT48_06970	COG0436	Aminotransferase
VT48_06975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
VT48_06980	COG1714	RDD family
VT48_06990	COG0835	chemotaxis
VT48_06990	COG0784	Response regulator, receiver
VT48_07000	COG2207	Transcriptional regulator
VT48_07000	COG1917	Cupin 2, conserved barrel domain protein
VT48_07005	COG0697	spore germination
VT48_07015	COG2814	Major facilitator Superfamily
VT48_07020	COG1376	ErfK ybiS ycfS ynhG family protein
VT48_07025	COG1408	metallophosphoesterase
VT48_07030	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_07035	COG2200	EAL domain
VT48_07040	COG3546	catalase activity
VT48_07045	COG4703	Protein of unknown function (DUF1797)
VT48_07050	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
VT48_07060	COG0517	IMP dehydrogenase activity
VT48_07065	COG0583	DNA-binding transcription factor activity
VT48_07075	COG0716	FMN binding
VT48_07085	COG0716	FMN binding
VT48_07090	COG2171	N-acyltransferase activity
VT48_07095	COG1473	amidohydrolase
VT48_07105	COG0668	transmembrane transport
VT48_07110	COG0450	alkyl hydroperoxide reductase
VT48_07115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_07130	COG0746	molybdenum cofactor guanylyltransferase activity
VT48_07135	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
VT48_07140	COG0303	'Molybdopterin
VT48_07145	COG1763	Mo-molybdopterin cofactor biosynthetic process
VT48_07150	COG0314	molybdopterin synthase activity
VT48_07155	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
VT48_07170	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
VT48_07175	COG1136	(ABC) transporter
VT48_07180	COG0577	efflux transmembrane transporter activity
VT48_07185	COG1349	DNA-binding transcription factor activity
VT48_07190	COG1105	Belongs to the carbohydrate kinase PfkB family
VT48_07195	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_07195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_07195	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_07200	COG0681	Belongs to the peptidase S26 family
VT48_07210	COG0488	(ABC) transporter
VT48_07215	COG2309	aminopeptidase activity
VT48_07220	COG1077	Cell shape determining protein MreB Mrl
VT48_07225	COG2002	toxin-antitoxin pair type II binding
VT48_07230	COG3852	Histidine kinase
VT48_07235	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
VT48_07235	COG2105	PFAM AIG2 family protein
VT48_07240	COG0569	domain protein
VT48_07245	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
VT48_07250	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
VT48_07260	COG0561	phosphatase activity
VT48_07265	COG0242	peptide deformylase activity
VT48_07280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VT48_07285	COG0022	dehydrogenase e1 component
VT48_07290	COG0508	dehydrogenase complex catalyzes the overall conversion of
VT48_07295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VT48_07300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_07305	COG1982	Orn Lys Arg decarboxylase major
VT48_07310	COG4476	Belongs to the UPF0223 family
VT48_07315	COG4493	Belongs to the UPF0637 family
VT48_07325	COG0483	inositol monophosphate 1-phosphatase activity
VT48_07340	COG1595	DNA-templated transcription, initiation
VT48_07370	COG4896	Protein conserved in bacteria
VT48_07380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
VT48_07385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
VT48_07390	COG2066	Belongs to the glutaminase family
VT48_07395	COG4838	Belongs to the UPF0358 family
VT48_07400	COG0772	Belongs to the SEDS family
VT48_07405	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
VT48_07415	COG1612	heme a metabolic process
VT48_07420	COG0109	protoheme IX farnesyltransferase activity
VT48_07425	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VT48_07425	COG2010	Cytochrome c
VT48_07430	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VT48_07435	COG1845	cytochrome c oxidase, subunit III
VT48_07440	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VT48_07445	COG3336	cytochrome c oxidase
VT48_07455	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
VT48_07460	COG2340	Cysteine-rich secretory protein family
VT48_07480	COG3679	Belongs to the UPF0342 family
VT48_07485	COG4471	UPF0298 protein
VT48_07490	COG0742	ribosomal rna small subunit methyltransferase
VT48_07495	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
VT48_07500	COG3314	Sporulation integral membrane protein YlbJ
VT48_07505	COG1752	Esterase of the alpha-beta hydrolase superfamily
VT48_07510	COG3480	Lon protease (S16) C-terminal proteolytic domain
VT48_07520	COG1399	metal-binding, possibly nucleic acid-binding protein
VT48_07525	COG0333	Belongs to the bacterial ribosomal protein bL32 family
VT48_07535	COG0454	-acetyltransferase
VT48_07540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
VT48_07545	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
VT48_07550	COG2001	Belongs to the MraZ family
VT48_07555	COG0275	rRNA processing
VT48_07560	COG4839	cell division protein FtsL
VT48_07570	COG0768	penicillin binding
VT48_07575	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
VT48_07580	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VT48_07585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VT48_07590	COG0772	Belongs to the SEDS family
VT48_07595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VT48_07600	COG0812	UDP-N-acetylmuramate dehydrogenase activity
VT48_07605	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
VT48_07610	COG3879	Bacterial protein of unknown function (DUF881)
VT48_07615	COG3879	Bacterial protein of unknown function (DUF881)
VT48_07620	COG3856	small basic protein
VT48_07625	COG0849	cell division
VT48_07630	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
VT48_07635	COG1404	Belongs to the peptidase S8 family
VT48_07635	COG4412	M6 family metalloprotease domain protein
VT48_07645	COG1191	sigma factor activity
VT48_07650	COG1191	sigma factor activity
VT48_07655	COG2390	Transcriptional regulator
VT48_07670	COG3730	PTS system glucitol sorbitol-specific
VT48_07675	COG3732	PTS system glucitol sorbitol-specific
VT48_07685	COG1119	ATPase activity
VT48_07690	COG1873	PFAM PRC-barrel domain
VT48_07700	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
VT48_07705	COG1799	cell septum assembly
VT48_07710	COG0762	integral membrane protein
VT48_07715	COG2302	S4 RNA-binding domain
VT48_07720	COG3599	regulation of cell shape
VT48_07725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
VT48_07730	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VT48_07735	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
VT48_07740	COG0564	pseudouridine synthase activity
VT48_07745	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
VT48_07750	COG2233	PERMEase
VT48_07755	COG0540	Belongs to the ATCase OTCase family
VT48_07760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
VT48_07765	COG0505	Belongs to the CarA family
VT48_07770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
VT48_07775	COG0543	2 iron, 2 sulfur cluster binding
VT48_07780	COG0167	dihydroorotate dehydrogenase activity
VT48_07785	COG0284	orotidine-5'-phosphate decarboxylase activity
VT48_07790	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
VT48_07795	COG0175	sulfate reduction
VT48_07800	COG0306	phosphate transporter
VT48_07805	COG2046	Belongs to the sulfate adenylyltransferase family
VT48_07810	COG0529	Catalyzes the synthesis of activated sulfate
VT48_07815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
VT48_07820	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
VT48_07825	COG1648	precorrin-2 dehydrogenase activity
VT48_07835	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
VT48_07840	COG1561	YicC-like family, N-terminal region
VT48_07845	COG2052	Domain of unknown function (DUF370)
VT48_07850	COG0194	GDP metabolic process
VT48_07855	COG1758	RNA polymerase activity
VT48_07860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VT48_07865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
VT48_07870	COG0242	peptide deformylase activity
VT48_07875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
VT48_07880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VT48_07880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
VT48_07885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
VT48_07890	COG0631	protein serine/threonine phosphatase activity
VT48_07895	COG2815	serine threonine protein kinase
VT48_07895	COG0515	serine threonine protein kinase
VT48_07900	COG1162	GTPase activity
VT48_07905	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VT48_07910	COG1564	THIamine pyrophosphokinase
VT48_07920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
VT48_07925	COG1302	Protein conserved in bacteria
VT48_07930	COG1461	Dihydroxyacetone kinase
VT48_07935	COG1760	l-serine dehydratase
VT48_07940	COG1760	l-serine dehydratase
VT48_07945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
VT48_07950	COG1349	DNA-binding transcription factor activity
VT48_07955	COG0416	fatty acid biosynthetic process
VT48_07960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
VT48_07965	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_07970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VT48_07980	COG1196	nuclear chromosome segregation
VT48_07985	COG0552	protein localization to endoplasmic reticulum
VT48_07990	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
VT48_07995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
VT48_08000	COG0228	four-way junction DNA binding
VT48_08005	COG1837	Belongs to the UPF0109 family
VT48_08015	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
VT48_08020	COG0336	Belongs to the RNA methyltransferase TrmD family
VT48_08025	COG0335	large ribosomal subunit rRNA binding
VT48_08030	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VT48_08035	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VT48_08045	COG2257	FlhB HrpN YscU SpaS Family
VT48_08050	COG0045	succinate-CoA ligase (ADP-forming) activity
VT48_08055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
VT48_08060	COG0758	DNA mediated transformation
VT48_08065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
VT48_08070	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
VT48_08075	COG4974	Belongs to the 'phage' integrase family
VT48_08080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
VT48_08085	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
VT48_08090	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
VT48_08095	COG1815	bacterial-type flagellum-dependent cell motility
VT48_08100	COG1558	bacterial-type flagellum-dependent cell motility
VT48_08105	COG1677	Flagellar hook-basal body complex protein FliE
VT48_08110	COG1766	The M ring may be actively involved in energy transduction
VT48_08115	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VT48_08120	COG1317	bacterial-type flagellum organization
VT48_08125	COG1157	protein secretion by the type III secretion system
VT48_08130	COG2882	bacterial-type flagellum organization
VT48_08135	COG3334	PFAM MgtE intracellular
VT48_08140	COG3144	bacterial-type flagellum assembly
VT48_08145	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
VT48_08150	COG4786	Flagellar basal body rod
VT48_08155	COG1582	Flagellar protein (FlbD)
VT48_08160	COG1580	Controls the rotational direction of flagella during chemotaxis
VT48_08165	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VT48_08170	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
VT48_08170	COG1776	CheC inhibitor of MCP methylation
VT48_08175	COG2201	protein-glutamate methylesterase activity
VT48_08180	COG3190	flagellar
VT48_08185	COG1338	Plays a role in the flagellum-specific transport system
VT48_08190	COG1987	bacterial-type flagellum assembly
VT48_08195	COG1684	flagellar biosynthetic protein fliR
VT48_08200	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VT48_08205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
VT48_08210	COG1419	protein localization to endoplasmic reticulum
VT48_08215	COG0455	bacterial-type flagellum organization
VT48_08220	COG2201	protein-glutamate methylesterase activity
VT48_08225	COG0643	Histidine kinase
VT48_08225	COG2198	Histidine kinase
VT48_08230	COG0835	chemotaxis
VT48_08235	COG1776	CheC inhibitor of MCP methylation
VT48_08245	COG1191	sigma factor activity
VT48_08260	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
VT48_08265	COG0528	UMP kinase activity
VT48_08270	COG0233	cytoplasmic translational termination
VT48_08275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
VT48_08280	COG4589	Belongs to the CDS family
VT48_08285	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
VT48_08290	COG0750	zinc metalloprotease
VT48_08295	COG0442	prolyl-tRNA aminoacylation
VT48_08300	COG2176	DNA-directed DNA polymerase activity
VT48_08325	COG0779	Required for maturation of 30S ribosomal subunits
VT48_08330	COG0195	Participates in both transcription termination and antitermination
VT48_08335	COG2740	Nucleic-acid-binding protein implicated in transcription termination
VT48_08340	COG1358	cellular component organization or biogenesis
VT48_08345	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
VT48_08350	COG1550	Protein conserved in bacteria
VT48_08355	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
VT48_08360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
VT48_08365	COG0196	riboflavin kinase activity
VT48_08370	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
VT48_08375	COG1185	polyribonucleotide nucleotidyltransferase activity
VT48_08380	COG0726	polysaccharide deacetylase
VT48_08385	COG0612	Peptidase, M16
VT48_08395	COG1873	PFAM PRC-barrel domain
VT48_08400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VT48_08405	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
VT48_08410	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
VT48_08415	COG0527	aspartate kinase activity
VT48_08425	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
VT48_08430	COG0740	serine-type endopeptidase activity
VT48_08440	COG4980	gas vesicle protein
VT48_08440	COG1674	ftsk spoiiie
VT48_08445	COG2188	Transcriptional regulator
VT48_08450	COG2814	Major facilitator Superfamily
VT48_08455	COG1033	growth of symbiont in host cell
VT48_08455	COG2409	Drug exporters of the RND superfamily
VT48_08460	COG0612	Peptidase, M16
VT48_08465	COG0612	Peptidase, M16
VT48_08475	COG2409	Drug exporters of the RND superfamily
VT48_08475	COG1033	growth of symbiont in host cell
VT48_08480	COG0300	oxidoreductase activity
VT48_08495	COG1426	Protein conserved in bacteria
VT48_08500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
VT48_08505	COG1058	Belongs to the CinA family
VT48_08505	COG1546	Belongs to the CinA family
VT48_08510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
VT48_08515	COG1418	mRNA catabolic process
VT48_08520	COG1692	metallophosphoesterase
VT48_08525	COG2359	stage V sporulation protein S
VT48_08530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
VT48_08535	COG1063	alcohol dehydrogenase
VT48_08540	COG0156	8-amino-7-oxononanoate synthase activity
VT48_08545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VT48_08550	COG4550	Control of competence regulator ComK, YlbF/YmcA
VT48_08560	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
VT48_08565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
VT48_08585	COG1329	Transcriptional regulator
VT48_08590	COG4195	phage-related replication protein
VT48_08595	COG0457	Tetratricopeptide repeat
VT48_08600	COG1404	Belongs to the peptidase S8 family
VT48_08605	COG4195	phage-related replication protein
VT48_08610	COG1764	response to oxidative stress
VT48_08615	COG2076	Multidrug Resistance protein
VT48_08640	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
VT48_08645	COG1923	regulation of RNA biosynthetic process
VT48_08660	COG1780	Probably involved in ribonucleotide reductase function
VT48_08665	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VT48_08670	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
VT48_08675	COG4112	unkown
VT48_08685	COG0464	growth
VT48_08690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
VT48_08695	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
VT48_08700	COG0789	Transcriptional regulator
VT48_08705	COG0174	glutamine synthetase
VT48_08730	COG0457	Tetratricopeptide repeat
VT48_08745	COG0604	alcohol dehydrogenase
VT48_08760	COG5444	nuclease activity
VT48_08785	COG5646	InterPro IPR014922
VT48_08810	COG0457	Tetratricopeptide repeat
VT48_08820	COG3619	membrane
VT48_08825	COG1793	dna ligase
VT48_08825	COG3285	dna ligase
VT48_08830	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
VT48_08835	COG4876	unkown
VT48_08845	COG1959	2 iron, 2 sulfur cluster binding
VT48_08850	COG0702	epimerase
VT48_08860	COG0247	lactate metabolic process
VT48_08865	COG1139	Iron-sulfur cluster binding protein
VT48_08870	COG1556	Lactate utilization protein
VT48_08885	COG2323	membrane
VT48_08890	COG1309	transcriptional regulator
VT48_08895	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VT48_08895	COG2124	cytochrome p450
VT48_08900	COG3591	Belongs to the peptidase S1B family
VT48_08905	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VT48_08910	COG3209	COG3209 Rhs family protein
VT48_08915	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_08930	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
VT48_08935	COG1388	LysM domain
VT48_08940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
VT48_08945	COG4224	UPF0291 protein
VT48_08950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
VT48_08960	COG3763	UPF0154 protein
VT48_08970	COG0785	Cytochrome C biogenesis protein
VT48_08975	COG4846	Membrane protein involved in cytochrome C biogenesis
VT48_08985	COG0071	Belongs to the small heat shock protein (HSP20) family
VT48_09000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
VT48_09005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_09020	COG0824	Thioesterase
VT48_09030	COG4841	protein insertion into membrane
VT48_09035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
VT48_09040	COG1832	CoA-binding protein
VT48_09045	COG0187	DNA topoisomerase II activity
VT48_09050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
VT48_09060	COG0738	Major facilitator superfamily
VT48_09065	COG0473	3-isopropylmalate dehydrogenase activity
VT48_09070	COG0110	maltose O-acetyltransferase activity
VT48_09075	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VT48_09080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
VT48_09085	COG0640	Transcriptional regulator
VT48_09095	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
VT48_09100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VT48_09110	COG1309	transcriptional regulator
VT48_09115	COG2249	NAD(P)H dehydrogenase (quinone) activity
VT48_09120	COG1733	regulation of RNA biosynthetic process
VT48_09130	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VT48_09135	COG0251	oxidation-reduction process
VT48_09170	COG0657	acetylesterase activity
VT48_09180	COG2723	6-phospho-beta-galactosidase activity
VT48_09185	COG1263	PTS System
VT48_09185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_09185	COG2190	(PTS) system
VT48_09200	COG2205	protein histidine kinase activity
VT48_09205	COG0745	RESPONSE REGULATOR receiver
VT48_09215	COG3507	Belongs to the glycosyl hydrolase 43 family
VT48_09220	COG1012	belongs to the aldehyde dehydrogenase family
VT48_09225	COG1486	melibiose metabolic process
VT48_09250	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
VT48_09265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_09275	COG0456	acetyltransferase
VT48_09280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VT48_09290	COG1846	Transcriptional regulator
VT48_09295	COG2814	Major facilitator Superfamily
VT48_09305	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_09305	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_09305	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_09310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_09310	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_09310	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
VT48_09315	COG1105	Belongs to the carbohydrate kinase PfkB family
VT48_09325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VT48_09345	COG1012	belongs to the aldehyde dehydrogenase family
VT48_09350	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
VT48_09355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VT48_09365	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VT48_09370	COG1024	Enoyl-CoA hydratase
VT48_09375	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VT48_09380	COG0511	ligase activity, forming carbon-carbon bonds
VT48_09385	COG0439	Biotin carboxylase
VT48_09390	COG0318	PFAM AMP-dependent synthetase and ligase
VT48_09395	COG1960	acyl-CoA dehydrogenase activity
VT48_09400	COG1649	PFAM Uncharacterised BCR, COG1649
VT48_09410	COG1349	DNA-binding transcription factor activity
VT48_09415	COG1942	4-Oxalocrotonate Tautomerase
VT48_09425	COG3835	regulator
VT48_09430	COG0277	FAD linked oxidase domain protein
VT48_09435	COG0247	lactate metabolic process
VT48_09455	COG0166	Belongs to the GPI family
VT48_09460	COG2246	polysaccharide biosynthetic process
VT48_09465	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VT48_09470	COG0586	Pfam SNARE associated Golgi protein
VT48_09475	COG1587	Uroporphyrinogen-III synthase
VT48_09485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VT48_09500	COG0534	Mate efflux family protein
VT48_09505	COG2027	D-alanyl-D-alanine carboxypeptidase
VT48_09510	COG4677	pectinesterase activity
VT48_09515	COG2323	membrane
VT48_09520	COG2146	nitrite reductase [NAD(P)H] activity
VT48_09525	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VT48_09530	COG0243	molybdopterin cofactor binding
VT48_09535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
VT48_09540	COG2223	nitrite transmembrane transporter activity
VT48_09545	COG0493	'glutamate synthase
VT48_09550	COG0070	glutamate synthase
VT48_09550	COG0069	glutamate synthase activity
VT48_09550	COG0067	glutamate synthase
VT48_09555	COG0583	DNA-binding transcription factor activity
VT48_09565	COG1132	(ABC) transporter
VT48_09570	COG0789	Transcriptional regulator
VT48_09570	COG4978	Transcriptional regulator
VT48_09575	COG0454	-acetyltransferase
VT48_09580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
VT48_09585	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
VT48_09590	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VT48_09600	COG0243	molybdopterin cofactor binding
VT48_09610	COG1070	Carbohydrate kinase
VT48_09615	COG2115	Belongs to the xylose isomerase family
VT48_09620	COG1940	carbohydrate kinase activity
VT48_09630	COG2211	Major facilitator Superfamily
VT48_09635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VT48_09640	COG1994	Peptidase M50
VT48_09660	COG1309	transcriptional regulator
VT48_09665	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VT48_09670	COG3708	Transcriptional regulator
VT48_09675	COG2378	regulation of single-species biofilm formation
VT48_09685	COG0640	Transcriptional regulator
VT48_09690	COG0531	amino acid
VT48_09695	COG0741	lytic transglycosylase activity
VT48_09700	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
VT48_09705	COG2079	MmgE PrpD family protein
VT48_09710	COG0372	Belongs to the citrate synthase family
VT48_09715	COG2322	membrane
VT48_09725	COG3584	3D domain protein
VT48_09725	COG1388	LysM domain
VT48_09730	COG0514	ATP-dependent DNA helicase (RecQ)
VT48_09735	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VT48_09755	COG1012	belongs to the aldehyde dehydrogenase family
VT48_09765	COG1657	PFAM Prenyltransferase squalene oxidase
VT48_09770	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VT48_09775	COG0385	Bile acid
VT48_09780	COG0508	dehydrogenase complex catalyzes the overall conversion of
VT48_09785	COG0567	Dehydrogenase, E1 component
VT48_09790	COG4548	von Willebrand factor, type A
VT48_09795	COG0714	Associated with various cellular activities
VT48_09800	COG2032	superoxide dismutase activity
VT48_09805	COG0791	NLP P60 protein
VT48_09805	COG1388	LysM domain
VT48_09810	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
VT48_09815	COG0534	Mate efflux family protein
VT48_09820	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VT48_09825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VT48_09835	COG2962	Rard protein
VT48_09850	COG1733	regulation of RNA biosynthetic process
VT48_09855	COG0778	Nitroreductase
VT48_09865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VT48_09870	COG3409	Peptidoglycan-binding domain 1 protein
VT48_09870	COG0793	Belongs to the peptidase S41A family
VT48_09875	COG2226	methyltransferase
VT48_09885	COG1876	peptidase activity
VT48_09890	COG0813	purine-nucleoside phosphorylase activity
VT48_09900	COG0671	phosphoesterase, PA-phosphatase related
VT48_09910	COG4479	Belongs to the UPF0346 family
VT48_09920	COG1509	lysine 2,3-aminomutase activity
VT48_09925	COG3829	transcription factor binding
VT48_09930	COG0463	Glycosyl transferase, family 2
VT48_09945	COG4641	Protein conserved in bacteria
VT48_09955	COG1086	Polysaccharide biosynthesis protein
VT48_09960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VT48_09965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
VT48_09970	COG1846	Transcriptional regulator
VT48_09990	COG4698	Protein conserved in bacteria
VT48_09995	COG2755	lipolytic protein G-D-S-L family
VT48_10000	COG1999	signal sequence binding
VT48_10015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
VT48_10020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
VT48_10025	COG1272	protein, Hemolysin III
VT48_10030	COG0204	Acyl-transferase
VT48_10035	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
VT48_10040	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
VT48_10045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VT48_10055	COG2136	Putative SAM-dependent methyltransferase
VT48_10055	COG2521	methyltransferase
VT48_10065	COG0129	dihydroxy-acid dehydratase activity
VT48_10070	COG1413	lyase activity
VT48_10075	COG1418	mRNA catabolic process
VT48_10080	COG0386	Belongs to the glutathione peroxidase family
VT48_10085	COG2759	Belongs to the formate--tetrahydrofolate ligase family
VT48_10090	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
VT48_10095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
VT48_10105	COG1278	Cold shock
VT48_10120	COG0328	RNA-DNA hybrid ribonuclease activity
VT48_10125	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
VT48_10130	COG0328	RNA-DNA hybrid ribonuclease activity
VT48_10140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VT48_10150	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VT48_10155	COG1755	Isoprenylcysteine carboxyl methyltransferase
VT48_10160	COG3424	synthase
VT48_10170	COG0726	polysaccharide deacetylase
VT48_10175	COG2233	PERMEase
VT48_10180	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VT48_10185	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
VT48_10190	COG1199	ATP-dependent helicase activity
VT48_10200	COG0116	Belongs to the methyltransferase superfamily
VT48_10205	COG3599	regulation of cell shape
VT48_10210	COG4474	Belongs to the UPF0398 family
VT48_10215	COG3359	exonuclease
VT48_10220	COG1111	helicase
VT48_10220	COG1205	dead DEAH box helicase
VT48_10225	COG1902	pentaerythritol trinitrate reductase activity
VT48_10230	COG2190	(PTS) system
VT48_10235	COG0071	Belongs to the small heat shock protein (HSP20) family
VT48_10265	COG3331	DNA recombination
VT48_10270	COG4499	WXG100 protein secretion system (Wss), protein YukC
VT48_10270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VT48_10280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
VT48_10285	COG3935	DnaD domain protein
VT48_10290	COG0017	Asparaginyl-tRNA synthetase
VT48_10295	COG5353	protein conserved in bacteria
VT48_10300	COG1199	ATP-dependent helicase activity
VT48_10300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
VT48_10305	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
VT48_10310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
VT48_10315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
VT48_10325	COG0617	tRNA 3'-terminal CCA addition
VT48_10330	COG0438	transferase activity, transferring glycosyl groups
VT48_10335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
VT48_10340	COG1803	Methylglyoxal synthase
VT48_10345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
VT48_10350	COG1694	Mazg nucleotide pyrophosphohydrolase
VT48_10355	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VT48_10365	COG4347	Protein of unknown function (DUF1405)
VT48_10370	COG2010	Cytochrome c
VT48_10370	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VT48_10375	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
VT48_10380	COG0723	plastoquinol--plastocyanin reductase activity
VT48_10390	COG5582	Belongs to the UPF0302 family
VT48_10395	COG0457	Tetratricopeptide repeat
VT48_10400	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
VT48_10405	COG0287	Prephenate dehydrogenase
VT48_10410	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
VT48_10415	COG0159	tryptophan synthase activity
VT48_10420	COG0133	tryptophan synthase activity
VT48_10425	COG0135	phosphoribosylanthranilate isomerase activity
VT48_10430	COG0134	indole-3-glycerol-phosphate synthase activity
VT48_10435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
VT48_10445	COG4401	Chorismate mutase type I
VT48_10450	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
VT48_10455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
VT48_10460	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
VT48_10465	COG0105	UTP biosynthetic process
VT48_10470	COG0142	geranyltranstransferase activity
VT48_10475	COG2226	methyltransferase
VT48_10480	COG0142	geranyltranstransferase activity
VT48_10490	COG0302	gtp cyclohydrolase
VT48_10495	COG0776	regulation of translation
VT48_10500	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
VT48_10515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
VT48_10520	COG1160	GTP binding
VT48_10540	COG1304	FMN binding
VT48_10545	COG0539	negative regulation of cytoplasmic translation
VT48_10550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
VT48_10560	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
VT48_10565	COG2959	enzyme of heme biosynthesis
VT48_10570	COG3773	Cell wall hydrolase
VT48_10570	COG3409	Peptidoglycan-binding domain 1 protein
VT48_10575	COG2339	peptidase activity
VT48_10580	COG0492	ferredoxin-NADP+ reductase activity
VT48_10585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VT48_10590	COG4862	establishment of competence for transformation
VT48_10595	COG1408	metallophosphoesterase
VT48_10605	COG1388	LysM domain
VT48_10610	COG1266	CAAX protease self-immunity
VT48_10615	COG0514	ATP-dependent DNA helicase (RecQ)
VT48_10620	COG4955	Helix-turn-helix domain
VT48_10625	COG1141	Ferredoxin
VT48_10630	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
VT48_10635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
VT48_10650	COG1595	DNA-templated transcription, initiation
VT48_10655	COG5002	protein histidine kinase activity
VT48_10660	COG0745	RESPONSE REGULATOR receiver
VT48_10665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VT48_10670	COG1333	cytochrome c biogenesis protein
VT48_10675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_10680	COG1187	pseudouridine synthase activity
VT48_10685	COG0700	Nucleoside recognition
VT48_10690	COG2715	membrane protein required for spore maturation
VT48_10695	COG1686	Belongs to the peptidase S11 family
VT48_10705	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
VT48_10710	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
VT48_10715	COG1547	Domain of unknown function (DUF309)
VT48_10720	COG0456	acetyltransferase
VT48_10725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
VT48_10735	COG0307	riboflavin synthase, alpha
VT48_10755	COG2814	Major facilitator Superfamily
VT48_10760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
VT48_10765	COG4086	secreted protein
VT48_10770	COG0019	diaminopimelate decarboxylase activity
VT48_10775	COG0697	spore germination
VT48_10790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
VT48_10810	COG1191	sigma factor activity
VT48_10815	COG2172	sigma factor antagonist activity
VT48_10825	COG1686	Belongs to the peptidase S11 family
VT48_10830	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
VT48_10835	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
VT48_10840	COG4974	Belongs to the 'phage' integrase family
VT48_10850	COG0735	belongs to the Fur family
VT48_10855	COG1300	Membrane
VT48_10860	COG1404	Belongs to the peptidase S8 family
VT48_10870	COG2153	protein acetylation
VT48_10875	COG1379	DNA repair
VT48_10880	COG0494	nUDIX hydrolase
VT48_10885	COG0667	Aldo Keto reductase
VT48_10895	COG1073	alpha beta
VT48_10900	COG0457	Tetratricopeptide repeat
VT48_10910	COG4918	Iron-sulphur cluster biosynthesis
VT48_10915	COG4305	rare lipoprotein A
VT48_10920	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
VT48_10920	COG0456	acetyltransferase
VT48_10925	COG0456	acetyltransferase
VT48_10935	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VT48_10945	COG2211	Major facilitator Superfamily
VT48_10950	COG1072	(Pantothenic acid kinase))
VT48_10955	COG0446	pyridine nucleotide-disulphide oxidoreductase
VT48_10965	COG0300	oxidoreductase activity
VT48_10970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VT48_10975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VT48_10985	COG4187	Peptidase family M20/M25/M40
VT48_10990	COG1902	pentaerythritol trinitrate reductase activity
VT48_10995	COG0596	Alpha beta hydrolase
VT48_11000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
VT48_11010	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
VT48_11015	COG2188	Transcriptional regulator
VT48_11020	COG2723	6-phospho-beta-galactosidase activity
VT48_11025	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VT48_11030	COG1447	Phosphotransferase system cellobiose-specific component IIA
VT48_11035	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VT48_11045	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_11055	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
VT48_11060	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
VT48_11070	COG0706	membrane insertase activity
VT48_11075	COG0835	chemotaxis
VT48_11080	COG2195	Cleaves the N-terminal amino acid of tripeptides
VT48_11085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
VT48_11090	COG0346	lactoylglutathione lyase activity
VT48_11095	COG1376	ErfK ybiS ycfS ynhG family protein
VT48_11100	COG4129	membrane
VT48_11105	COG1126	abc transporter atp-binding protein
VT48_11110	COG0765	amino acid transport
VT48_11115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_11125	COG1597	lipid kinase activity
VT48_11135	COG0508	dehydrogenase complex catalyzes the overall conversion of
VT48_11140	COG0022	dehydrogenase e1 component
VT48_11145	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
VT48_11150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
VT48_11155	COG3426	butyrate kinase activity
VT48_11165	COG0280	phosphate acetyltransferase
VT48_11170	COG3829	transcription factor binding
VT48_11170	COG3290	protein histidine kinase activity
VT48_11180	COG0584	glycerophosphoryl diester phosphodiesterase
VT48_11185	COG0457	Tetratricopeptide repeat
VT48_11190	COG0745	RESPONSE REGULATOR receiver
VT48_11195	COG0750	zinc metalloprotease
VT48_11200	COG0497	DNA recombination
VT48_11205	COG1438	arginine binding
VT48_11210	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
VT48_11215	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
VT48_11220	COG0142	geranyltranstransferase activity
VT48_11225	COG1722	exodeoxyribonuclease VII activity
VT48_11230	COG1570	exodeoxyribonuclease VII activity
VT48_11235	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
VT48_11240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
VT48_11245	COG1302	Protein conserved in bacteria
VT48_11250	COG0439	Biotin carboxylase
VT48_11255	COG0511	ligase activity, forming carbon-carbon bonds
VT48_11295	COG3854	ATPases associated with a variety of cellular activities
VT48_11305	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
VT48_11310	COG0006	proline dipeptidase activity
VT48_11315	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
VT48_11325	COG3872	metal-dependent enzyme
VT48_11335	COG1752	Esterase of the alpha-beta hydrolase superfamily
VT48_11340	COG1321	iron dependent repressor
VT48_11345	COG0095	Lipoate-protein ligase
VT48_11350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VT48_11355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VT48_11360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
VT48_11365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
VT48_11370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VT48_11390	COG0681	Belongs to the peptidase S26 family
VT48_11425	COG4970	Tfp pilus assembly protein FimT
VT48_11430	COG4537	Required for transformation and DNA binding
VT48_11435	COG1459	type II secretion system
VT48_11440	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
VT48_11445	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_11455	COG1393	Belongs to the ArsC family
VT48_11465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VT48_11475	COG0011	TIGRFAM Protein of
VT48_11480	COG2814	Major facilitator Superfamily
VT48_11485	COG2866	Carboxypeptidase
VT48_11490	COG1368	sulfuric ester hydrolase activity
VT48_11495	COG1940	carbohydrate kinase activity
VT48_11500	COG4483	Protein conserved in bacteria
VT48_11505	COG0705	Rhomboid family
VT48_11505	COG0457	Tetratricopeptide repeat
VT48_11515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
VT48_11520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VT48_11535	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VT48_11540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VT48_11545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
VT48_11550	COG0581	inorganic phosphate transmembrane transporter activity
VT48_11555	COG0573	inorganic phosphate transmembrane transporter activity
VT48_11560	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
VT48_11570	COG0477	Major facilitator Superfamily
VT48_11575	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
VT48_11580	COG2839	Protein conserved in bacteria
VT48_11585	COG5521	maltodextrose utilization protein MalA
VT48_11590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
VT48_11595	COG1388	LysM domain
VT48_11600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
VT48_11605	COG4709	membrane
VT48_11610	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
VT48_11615	COG1940	carbohydrate kinase activity
VT48_11620	COG0735	belongs to the Fur family
VT48_11625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VT48_11630	COG1121	(ABC) transporter
VT48_11635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VT48_11650	COG0513	Belongs to the DEAD box helicase family
VT48_11660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
VT48_11665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
VT48_11670	COG2384	SAM-dependent methyltransferase
VT48_11675	COG2010	Cytochrome c
VT48_11680	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
VT48_11685	COG0358	DNA primase activity
VT48_11690	COG1671	Belongs to the UPF0178 family
VT48_11695	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
VT48_11700	COG0517	IMP dehydrogenase activity
VT48_11705	COG0751	glycine-tRNA ligase activity
VT48_11710	COG0752	glycyl-tRNA synthetase alpha subunit
VT48_11715	COG1381	Involved in DNA repair and RecF pathway recombination
VT48_11720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
VT48_11725	COG0295	cytidine deaminase activity
VT48_11730	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
VT48_11735	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
VT48_11740	COG1480	7TM receptor with intracellular HD hydrolase
VT48_11745	COG1702	phosphate starvation-inducible protein PhoH
VT48_11750	COG0561	phosphatase activity
VT48_11765	COG4864	UPF0365 protein
VT48_11770	COG1030	water channel activity
VT48_11775	COG1610	YqeY-like protein
VT48_11780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
VT48_11785	COG1283	sodium-dependent phosphate transmembrane transporter activity
VT48_11790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
VT48_11795	COG1385	rRNA (uridine-N3-)-methyltransferase activity
VT48_11800	COG2264	protein methyltransferase activity
VT48_11805	COG0484	heat shock protein binding
VT48_11810	COG0443	Heat shock 70 kDa protein
VT48_11815	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
VT48_11820	COG1420	regulation of RNA biosynthetic process
VT48_11825	COG0635	Involved in the biosynthesis of porphyrin-containing compound
VT48_11830	COG0481	GTPase activity
VT48_11840	COG0860	N-Acetylmuramoyl-L-alanine amidase
VT48_11845	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
VT48_11850	COG0268	Binds directly to 16S ribosomal RNA
VT48_11855	COG1466	dna polymerase III delta subunit
VT48_11865	COG2333	competence protein COMEC
VT48_11865	COG0658	competence protein
VT48_11870	COG2131	deaminase
VT48_11875	COG1555	photosystem II stabilization
VT48_11875	COG1596	polysaccharide export
VT48_11880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
VT48_11885	COG2226	methyltransferase
VT48_11890	COG0799	negative regulation of ribosome biogenesis
VT48_11895	COG1713	HD superfamily hydrolase involved in NAD metabolism
VT48_11900	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
VT48_11905	COG1534	Rna-binding protein
VT48_11910	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VT48_11915	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
VT48_11920	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
VT48_11930	COG2755	lipolytic protein G-D-S-L family
VT48_11940	COG0457	Tetratricopeptide repeat
VT48_11955	COG2186	Transcriptional regulator
VT48_11965	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_11970	COG3958	Transketolase
VT48_11975	COG3959	Transketolase, thiamine diphosphate binding domain
VT48_12000	COG0726	polysaccharide deacetylase
VT48_12035	COG1131	(ABC) transporter
VT48_12060	COG2160	L-arabinose isomerase activity
VT48_12075	COG1609	Transcriptional regulator
VT48_12085	COG1846	Transcriptional regulator
VT48_12095	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
VT48_12100	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
VT48_12105	COG1733	regulation of RNA biosynthetic process
VT48_12175	COG2602	Beta-lactamase
VT48_12180	COG1960	acyl-CoA dehydrogenase activity
VT48_12185	COG1126	abc transporter atp-binding protein
VT48_12190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_12195	COG0765	amino acid transport
VT48_12205	COG3546	catalase activity
VT48_12210	COG1063	alcohol dehydrogenase
VT48_12220	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_12230	COG1115	amino acid carrier protein
VT48_12235	COG0583	DNA-binding transcription factor activity
VT48_12240	COG0842	Transport permease protein
VT48_12245	COG0842	Transport permease protein
VT48_12245	COG1511	domain protein
VT48_12250	COG1131	(ABC) transporter
VT48_12255	COG1063	alcohol dehydrogenase
VT48_12260	COG2226	methyltransferase
VT48_12270	COG0626	cystathionine gamma-synthase activity
VT48_12275	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VT48_12280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
VT48_12285	COG2226	methyltransferase
VT48_12300	COG0768	penicillin binding
VT48_12305	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
VT48_12310	COG0572	uridine kinase
VT48_12330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
VT48_12335	COG0183	Belongs to the thiolase family
VT48_12340	COG0318	PFAM AMP-dependent synthetase and ligase
VT48_12345	COG1268	BioY protein
VT48_12350	COG3906	Belongs to the UPF0473 family
VT48_12355	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
VT48_12360	COG4472	Bacterial protein of unknown function (DUF965)
VT48_12365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
VT48_12370	COG0628	permease
VT48_12375	COG1126	abc transporter atp-binding protein
VT48_12380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_12385	COG0765	amino acid transport
VT48_12390	COG0765	amino acid transport
VT48_12400	COG3881	PFAM PRC-barrel domain
VT48_12405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
VT48_12410	COG0457	Tetratricopeptide repeat
VT48_12415	COG0482	sulfurtransferase activity
VT48_12420	COG1104	cysteine desulfurase activity
VT48_12425	COG1959	2 iron, 2 sulfur cluster binding
VT48_12430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
VT48_12435	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
VT48_12445	COG0124	histidyl-tRNA synthetase
VT48_12450	COG0860	N-Acetylmuramoyl-L-alanine amidase
VT48_12450	COG3103	Sh3 type 3 domain protein
VT48_12450	COG4991	sh3 domain protein
VT48_12455	COG1490	D-aminoacyl-tRNA deacylase activity
VT48_12460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
VT48_12465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
VT48_12470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
VT48_12470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
VT48_12475	COG5416	Lipopolysaccharide assembly protein A domain
VT48_12480	COG0490	domain, Protein
VT48_12485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VT48_12485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
VT48_12495	COG2244	polysaccharide biosynthetic process
VT48_12500	COG2323	membrane
VT48_12510	COG1862	Preprotein translocase
VT48_12515	COG0343	queuine tRNA-ribosyltransferase activity
VT48_12520	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
VT48_12530	COG2255	four-way junction helicase activity
VT48_12535	COG0632	four-way junction helicase activity
VT48_12545	COG2112	serine threonine protein kinase
VT48_12555	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
VT48_12570	COG1388	LysM domain
VT48_12575	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
VT48_12580	COG0157	Belongs to the NadC ModD family
VT48_12585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
VT48_12590	COG1104	cysteine desulfurase activity
VT48_12595	COG1827	regulation of RNA biosynthetic process
VT48_12600	COG0077	Prephenate dehydratase
VT48_12605	COG4492	Belongs to the UPF0735 family
VT48_12610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
VT48_12615	COG3290	protein histidine kinase activity
VT48_12620	COG0211	Belongs to the bacterial ribosomal protein bL27 family
VT48_12625	COG2868	ribosomal protein
VT48_12630	COG0261	This protein binds to 23S rRNA in the presence of protein L20
VT48_12635	COG1994	Peptidase M50
VT48_12640	COG0739	heme binding
VT48_12645	COG2894	cell division
VT48_12650	COG0850	regulation of cytokinetic process
VT48_12655	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
VT48_12660	COG1792	Involved in formation and maintenance of cell shape
VT48_12665	COG1077	Cell shape determining protein MreB Mrl
VT48_12670	COG2003	Belongs to the UPF0758 family
VT48_12675	COG0424	maF-like protein
VT48_12690	COG0285	dihydrofolate synthase activity
VT48_12695	COG0525	valine-tRNA ligase activity
VT48_12705	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VT48_12710	COG1388	LysM domain
VT48_12715	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
VT48_12720	COG0113	porphobilinogen synthase activity
VT48_12725	COG1587	Uroporphyrinogen-III synthase
VT48_12730	COG0181	hydroxymethylbilane synthase activity
VT48_12735	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
VT48_12740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VT48_12750	COG0218	Necessary for normal cell division and for the maintenance of normal septation
VT48_12755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
VT48_12760	COG0470	DNA polymerase III
VT48_12760	COG1067	ATP-dependent peptidase activity
VT48_12765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
VT48_12770	COG0544	peptidyl-prolyl cis-trans isomerase activity
VT48_12775	COG0457	Tetratricopeptide repeat
VT48_12775	COG1477	protein flavinylation
VT48_12780	COG0066	3-isopropylmalate dehydratase activity
VT48_12785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
VT48_12790	COG0473	3-isopropylmalate dehydrogenase activity
VT48_12795	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
VT48_12800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
VT48_12805	COG0440	acetolactate synthase activity
VT48_12810	COG0028	Belongs to the TPP enzyme family
VT48_12815	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VT48_12820	COG2706	6-phosphogluconolactonase activity
VT48_12825	COG3339	Conserved Protein
VT48_12830	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
VT48_12835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
VT48_12840	COG1696	Membrane protein involved in D-alanine export
VT48_12845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
VT48_12875	COG0582	viral genome integration into host DNA
VT48_12890	COG0622	Phosphoesterase
VT48_12895	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
VT48_12900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
VT48_12905	COG5401	PFAM Sporulation and spore germination
VT48_12910	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
VT48_12915	COG1846	Transcriptional regulator
VT48_12920	COG2197	response regulator
VT48_12925	COG2851	Citrate transporter
VT48_12930	COG0583	DNA-binding transcription factor activity
VT48_12935	COG2828	Protein conserved in bacteria
VT48_12945	COG0824	Thioesterase
VT48_12950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
VT48_12955	COG1053	succinate dehydrogenase
VT48_12960	COG2009	succinate dehydrogenase
VT48_12965	COG1719	4-vinyl reductase, 4VR
VT48_12970	COG0527	aspartate kinase activity
VT48_12975	COG0322	excinuclease ABC activity
VT48_12980	COG3118	belongs to the thioredoxin family
VT48_12985	COG3534	alpha-L-arabinofuranosidase
VT48_12990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
VT48_12995	COG2086	electron transfer activity
VT48_13000	COG1024	Enoyl-CoA hydratase
VT48_13005	COG1309	transcriptional regulator
VT48_13010	COG0318	PFAM AMP-dependent synthetase and ligase
VT48_13020	COG3766	membrane
VT48_13025	COG1193	negative regulation of DNA recombination
VT48_13030	COG1796	DNA polymerase
VT48_13030	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VT48_13035	COG1286	toxin biosynthetic process
VT48_13040	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
VT48_13045	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
VT48_13050	COG0072	phenylalanine-tRNA ligase activity
VT48_13050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VT48_13055	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
VT48_13060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
VT48_13070	COG1966	Carbon starvation protein
VT48_13075	COG1363	Peptidase, m42
VT48_13085	COG3326	Membrane
VT48_13090	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
VT48_13095	COG0291	Belongs to the bacterial ribosomal protein bL35 family
VT48_13100	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
VT48_13120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
VT48_13130	COG0398	Pfam SNARE associated Golgi protein
VT48_13135	COG1484	DNA-dependent DNA replication
VT48_13140	COG3611	Membrane attachment protein
VT48_13145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
VT48_13155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
VT48_13160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VT48_13165	COG0237	dephospho-CoA kinase activity
VT48_13170	COG1971	Probably functions as a manganese efflux pump
VT48_13175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
VT48_13180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VT48_13180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
VT48_13185	COG5002	protein histidine kinase activity
VT48_13190	COG0745	RESPONSE REGULATOR receiver
VT48_13195	COG0039	L-malate dehydrogenase activity
VT48_13200	COG0538	isocitrate dehydrogenase activity
VT48_13205	COG0372	Belongs to the citrate synthase family
VT48_13210	COG2707	UPF0756 membrane protein
VT48_13215	COG0628	permease
VT48_13220	COG3030	protein affecting phage T7 exclusion by the F plasmid
VT48_13230	COG0205	6-phosphofructokinase activity
VT48_13235	COG0825	malonyl-CoA metabolic process
VT48_13240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
VT48_13245	COG0281	malic enzyme
VT48_13250	COG0587	DNA-directed DNA polymerase activity
VT48_13270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
VT48_13280	COG4109	DRTGG domain
VT48_13285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
VT48_13290	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_13300	COG0165	Argininosuccinate lyase
VT48_13305	COG0137	argininosuccinate synthase activity
VT48_13310	COG0521	Mo-molybdopterin cofactor biosynthetic process
VT48_13315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
VT48_13320	COG0827	DNA restriction-modification system
VT48_13325	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
VT48_13330	COG3874	Sporulation protein YtfJ
VT48_13340	COG1714	RDD family
VT48_13345	COG0616	signal peptide processing
VT48_13350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
VT48_13360	COG3239	Fatty acid desaturase
VT48_13365	COG4585	Histidine kinase
VT48_13370	COG2197	response regulator
VT48_13375	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_13380	COG0745	RESPONSE REGULATOR receiver
VT48_13385	COG2205	protein histidine kinase activity
VT48_13390	COG0772	Belongs to the SEDS family
VT48_13395	COG1695	Transcriptional regulator
VT48_13400	COG1136	(ABC) transporter
VT48_13405	COG0577	efflux transmembrane transporter activity
VT48_13410	COG0402	S-adenosylhomocysteine deaminase activity
VT48_13415	COG2249	NAD(P)H dehydrogenase (quinone) activity
VT48_13430	COG1279	arginine transmembrane transporter activity
VT48_13435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VT48_13445	COG0301	tRNA thio-modification
VT48_13450	COG1104	cysteine desulfurase activity
VT48_13455	COG1114	Component of the transport system for branched-chain amino acids
VT48_13460	COG1114	Component of the transport system for branched-chain amino acids
VT48_13465	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
VT48_13470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
VT48_13475	COG1309	transcriptional regulator
VT48_13480	COG1956	GAF domain-containing protein
VT48_13485	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
VT48_13495	COG1335	isochorismatase
VT48_13505	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
VT48_13510	COG0732	type I restriction modification DNA specificity domain
VT48_13525	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
VT48_13530	COG2329	Antibiotic biosynthesis monooxygenase
VT48_13535	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
VT48_13540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
VT48_13545	COG0454	-acetyltransferase
VT48_13550	COG0517	IMP dehydrogenase activity
VT48_13555	COG0123	including yeast histone deacetylase and acetoin utilization protein
VT48_13560	COG1609	Transcriptional regulator
VT48_13565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
VT48_13565	COG1605	Chorismate mutase
VT48_13570	COG3118	belongs to the thioredoxin family
VT48_13575	COG4980	gas vesicle protein
VT48_13580	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
VT48_13585	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
VT48_13590	COG1674	ftsk spoiiie
VT48_13595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
VT48_13600	COG4848	Belongs to the UPF0354 family
VT48_13605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_13620	COG1363	Peptidase, m42
VT48_13625	COG5584	Small secreted protein
VT48_13630	COG0281	malic enzyme
VT48_13635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VT48_13640	COG0220	tRNA (guanine-N7-)-methyltransferase activity
VT48_13650	COG0510	thiamine kinase activity
VT48_13655	COG1597	lipid kinase activity
VT48_13665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
VT48_13670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
VT48_13675	COG3340	Belongs to the peptidase S51 family
VT48_13680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
VT48_13685	COG2252	PERMEase
VT48_13690	COG1349	DNA-binding transcription factor activity
VT48_13695	COG1187	pseudouridine synthase activity
VT48_13700	COG2244	polysaccharide biosynthetic process
VT48_13705	COG2081	HI0933 family
VT48_13715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
VT48_13720	COG3196	Protein conserved in bacteria
VT48_13730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
VT48_13735	COG5578	integral membrane protein
VT48_13740	COG0673	inositol 2-dehydrogenase activity
VT48_13745	COG1653	transport
VT48_13750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
VT48_13755	COG4209	transmembrane transport
VT48_13760	COG2207	Transcriptional regulator
VT48_13765	COG1733	regulation of RNA biosynthetic process
VT48_13770	COG2814	Major facilitator Superfamily
VT48_13775	COG0656	L-ascorbic acid biosynthetic process
VT48_13780	COG1653	transport
VT48_13785	COG0395	ABC-type sugar transport system, permease component
VT48_13790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VT48_13795	COG1073	alpha beta
VT48_13800	COG0495	leucyl-tRNA aminoacylation
VT48_13810	COG2202	Pas domain
VT48_13810	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_13815	COG2433	Pfam Transposase IS66
VT48_13820	COG0577	efflux transmembrane transporter activity
VT48_13825	COG1136	(ABC) transporter
VT48_13835	COG1131	(ABC) transporter
VT48_13840	COG1725	Transcriptional regulator
VT48_13860	COG1242	4 iron, 4 sulfur cluster binding
VT48_13865	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
VT48_13870	COG4326	sporulation control protein
VT48_13880	COG2267	carboxylic ester hydrolase activity
VT48_13885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
VT48_13890	COG0367	asparagine synthase
VT48_13895	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
VT48_13900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
VT48_13910	COG1506	peptidase
VT48_13915	COG1233	COG1233 Phytoene dehydrogenase and related
VT48_13935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
VT48_13940	COG1116	anion transmembrane transporter activity
VT48_13945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
VT48_13950	COG0494	nUDIX hydrolase
VT48_13955	COG2310	stress, protein
VT48_13970	COG4824	toxin secretion phage lysis holin
VT48_13980	COG0783	Belongs to the Dps family
VT48_13995	COG1854	S-ribosylhomocysteine lyase activity
VT48_14000	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
VT48_14005	COG0288	reversible hydration of carbon dioxide
VT48_14010	COG0803	Belongs to the bacterial solute-binding protein 9 family
VT48_14010	COG3443	Belongs to the bacterial solute-binding protein 9 family
VT48_14020	COG1271	oxidase subunit
VT48_14025	COG1294	oxidase, subunit
VT48_14035	COG4948	Mandelate Racemase Muconate Lactonizing
VT48_14040	COG0318	PFAM AMP-dependent synthetase and ligase
VT48_14045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
VT48_14050	COG0596	Alpha beta hydrolase
VT48_14055	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
VT48_14060	COG1169	isochorismate synthase
VT48_14065	COG1575	Belongs to the MenA family. Type 1 subfamily
VT48_14070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
VT48_14200	COG3859	Proton-coupled thiamine transporter YuaJ
VT48_14205	COG1247	-acetyltransferase
VT48_14210	COG3339	Conserved Protein
VT48_14215	COG0772	Belongs to the SEDS family
VT48_14220	COG0772	Belongs to the SEDS family
VT48_14225	COG2268	Band 7 protein
VT48_14230	COG1585	Membrane protein implicated in regulation of membrane protease activity
VT48_14235	COG2318	DinB family
VT48_14240	COG1454	alcohol dehydrogenase
VT48_14250	COG1510	regulation of RNA biosynthetic process
VT48_14265	COG3409	Peptidoglycan-binding domain 1 protein
VT48_14265	COG5632	N-Acetylmuramoyl-L-alanine amidase
VT48_14315	COG3778	Protein conserved in bacteria
VT48_14320	COG3299	homolog of phage Mu protein gp47
VT48_14325	COG3628	GPW Gp25 family protein
VT48_14335	COG4193	domain, Protein
VT48_14340	COG1652	LysM domain
VT48_14345	COG3953	SLT domain
VT48_14345	COG3953	SLT domain
VT48_14345	COG5280	Phage tail tape measure protein TP901
VT48_14345	COG5280	Phage tail tape measure protein TP901
VT48_14390	COG4653	Phage capsid family
VT48_14395	COG0338	D12 class N6 adenine-specific DNA methyltransferase
VT48_14400	COG5518	Phage portal protein
VT48_14405	COG1783	phage Terminase large subunit
VT48_14410	COG5484	DNA packaging
VT48_14415	COG1595	DNA-templated transcription, initiation
VT48_14425	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
VT48_14440	COG1396	sequence-specific DNA binding
VT48_14450	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
VT48_14465	COG0628	permease
VT48_14475	COG0673	inositol 2-dehydrogenase activity
VT48_14480	COG0693	protein deglycase activity
VT48_14485	COG0840	transmembrane signaling receptor activity
VT48_14490	COG0840	transmembrane signaling receptor activity
VT48_14495	COG0840	transmembrane signaling receptor activity
VT48_14500	COG0840	transmembrane signaling receptor activity
VT48_14515	COG2070	2-Nitropropane dioxygenase
VT48_14520	COG0432	Pfam Uncharacterised protein family UPF0047
VT48_14525	COG1253	flavin adenine dinucleotide binding
VT48_14530	COG2738	Putative neutral zinc metallopeptidase
VT48_14540	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
VT48_14555	COG0166	Belongs to the GPI family
VT48_14560	COG1979	alcohol dehydrogenase
VT48_14565	COG1979	alcohol dehydrogenase
VT48_14570	COG2155	Conserved Protein
VT48_14575	COG1098	S1 RNA binding domain
VT48_14580	COG0436	Aminotransferase
VT48_14585	COG1522	sequence-specific DNA binding
VT48_14590	COG2267	carboxylic ester hydrolase activity
VT48_14600	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
VT48_14605	COG2205	protein histidine kinase activity
VT48_14615	COG5018	Exonuclease
VT48_14620	COG2814	Major facilitator Superfamily
VT48_14625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VT48_14630	COG3011	Protein conserved in bacteria
VT48_14640	COG3290	protein histidine kinase activity
VT48_14645	COG4565	transcriptional regulatory protein
VT48_14670	COG3493	citrate carrier protein
VT48_14685	COG2111	Na H antiporter
VT48_14685	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
VT48_14690	COG2111	Na H antiporter
VT48_14695	COG1006	Multisubunit Na H antiporter MnhC subunit
VT48_14700	COG0651	ATP synthesis coupled electron transport
VT48_14705	COG1863	multisubunit Na H antiporter MnhE subunit
VT48_14710	COG2212	antiporter activity
VT48_14715	COG1320	monovalent cation:proton antiporter activity
VT48_14720	COG2050	protein possibly involved in aromatic compounds catabolism
VT48_14725	COG2197	response regulator
VT48_14730	COG4585	Histidine kinase
VT48_14740	COG0142	geranyltranstransferase activity
VT48_14755	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
VT48_14760	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
VT48_14765	COG1335	isochorismatase
VT48_14770	COG5506	Protein of unknown function (DUF1694)
VT48_14790	COG0628	permease
VT48_14805	COG1418	mRNA catabolic process
VT48_14810	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_14820	COG1511	domain protein
VT48_14825	COG0433	COG0433 Predicted ATPase
VT48_14825	COG1674	ftsk spoiiie
VT48_14830	COG4499	WXG100 protein secretion system (Wss), protein YukC
VT48_14835	COG5417	Belongs to the EsaB family
VT48_14840	COG4842	Belongs to the WXG100 family
VT48_14845	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
VT48_14845	COG2508	Transcriptional regulator
VT48_14850	COG0686	Belongs to the AlaDH PNT family
VT48_14855	COG1268	BioY protein
VT48_14860	COG2056	Na+-H+ antiporter family
VT48_14865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
VT48_14870	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
VT48_14875	COG3584	3D domain protein
VT48_14885	COG1252	NADH dehydrogenase
VT48_14890	COG0492	ferredoxin-NADP+ reductase activity
VT48_14905	COG0316	Belongs to the HesB IscA family
VT48_14910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
VT48_14915	COG4844	belongs to the
VT48_14920	COG1252	NADH dehydrogenase
VT48_14930	COG4837	Protein of unknown function (DUF1462)
VT48_14935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
VT48_14940	COG1506	peptidase
VT48_14940	COG4946	Tricorn protease homolog
VT48_14940	COG0823	Involved in the tonB-independent uptake of proteins
VT48_14945	COG0083	homoserine kinase activity
VT48_14950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
VT48_14955	COG0460	homoserine dehydrogenase
VT48_14960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VT48_14965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
VT48_14970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
VT48_14975	COG0647	UMP catabolic process
VT48_14980	COG2445	Protein of unknown function DUF86
VT48_14985	COG4470	Protein conserved in bacteria
VT48_14995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
VT48_15000	COG0739	heme binding
VT48_15020	COG3377	Domain of unknown function (DUF1805)
VT48_15025	COG0737	Belongs to the 5'-nucleotidase family
VT48_15030	COG1801	Protein of unknown function DUF72
VT48_15035	COG2508	Transcriptional regulator
VT48_15040	COG2140	Oxalate decarboxylase
VT48_15045	COG2814	Major facilitator Superfamily
VT48_15050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
VT48_15055	COG2356	endonuclease I
VT48_15070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_15100	COG0642	Histidine kinase
VT48_15100	COG5002	protein histidine kinase activity
VT48_15105	COG0745	RESPONSE REGULATOR receiver
VT48_15110	COG2311	Membrane
VT48_15120	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
VT48_15125	COG1090	epimerase
VT48_15145	COG0719	Fe-S assembly protein
VT48_15150	COG0822	iron-sulfur transferase activity
VT48_15155	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
VT48_15160	COG0719	Fe-S assembly protein
VT48_15165	COG0396	ATPase activity
VT48_15175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
VT48_15180	COG1464	Belongs to the NlpA lipoprotein family
VT48_15185	COG2011	ABC-type metal ion transport system permease component
VT48_15190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
VT48_15200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
VT48_15205	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
VT48_15215	COG0509	glycine decarboxylation via glycine cleavage system
VT48_15220	COG1393	Belongs to the ArsC family
VT48_15225	COG1960	acyl-CoA dehydrogenase activity
VT48_15230	COG0183	Belongs to the thiolase family
VT48_15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
VT48_15235	COG1024	Enoyl-CoA hydratase
VT48_15245	COG5577	PFAM Coat F domain
VT48_15255	COG1120	ATPase activity
VT48_15265	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_15270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VT48_15275	COG0745	RESPONSE REGULATOR receiver
VT48_15280	COG2205	protein histidine kinase activity
VT48_15280	COG2770	Histidine kinase
VT48_15285	COG1309	transcriptional regulator
VT48_15290	COG0114	fumarate hydratase activity
VT48_15295	COG0697	spore germination
VT48_15300	COG0814	amino acid
VT48_15315	COG2197	response regulator
VT48_15320	COG4585	Histidine kinase
VT48_15325	COG4758	membrane
VT48_15335	COG1842	Phage shock protein A
VT48_15340	COG4758	membrane
VT48_15345	COG2096	Adenosyltransferase
VT48_15350	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_15355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
VT48_15365	COG3604	Transcriptional regulator
VT48_15380	COG1454	alcohol dehydrogenase
VT48_15385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
VT48_15390	COG1120	ATPase activity
VT48_15395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_15410	COG2721	sulfolactate sulfo-lyase activity
VT48_15415	COG0246	Mannitol dehydrogenase
VT48_15420	COG1609	Transcriptional regulator
VT48_15425	COG1904	glucuronate isomerase
VT48_15430	COG2205	protein histidine kinase activity
VT48_15435	COG0745	RESPONSE REGULATOR receiver
VT48_15440	COG1120	ATPase activity
VT48_15445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_15460	COG0531	amino acid
VT48_15475	COG1988	membrane-bound metal-dependent
VT48_15480	COG1368	sulfuric ester hydrolase activity
VT48_15485	COG0725	ABC transporter, periplasmic molybdate-binding protein
VT48_15490	COG4149	molybdate abc transporter
VT48_15495	COG0656	L-ascorbic acid biosynthetic process
VT48_15500	COG1940	carbohydrate kinase activity
VT48_15505	COG0025	NhaP-type Na H and K H
VT48_15510	COG2860	membrane
VT48_15515	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
VT48_15520	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
VT48_15525	COG2217	Heavy metal translocating P-type atpase
VT48_15530	COG1121	(ABC) transporter
VT48_15535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
VT48_15540	COG0803	Belongs to the bacterial solute-binding protein 9 family
VT48_15550	COG3226	Transcriptional regulator
VT48_15555	COG0784	Response regulator, receiver
VT48_15560	COG4191	Histidine kinase
VT48_15565	COG1027	Aspartate ammonia-lyase
VT48_15580	COG2217	Heavy metal translocating P-type atpase
VT48_15585	COG2608	mercury ion transmembrane transporter activity
VT48_15590	COG1937	Protein conserved in bacteria
VT48_15600	COG3706	GGDEF domain
VT48_15600	COG0745	RESPONSE REGULATOR receiver
VT48_15620	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
VT48_15625	COG0557	exoribonuclease II activity
VT48_15630	COG1647	Serine aminopeptidase, S33
VT48_15635	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
VT48_15640	COG2002	toxin-antitoxin pair type II binding
VT48_15645	COG1476	TRANSCRIPTIONal
VT48_15650	COG1396	sequence-specific DNA binding
VT48_15655	COG1396	sequence-specific DNA binding
VT48_15660	COG1733	regulation of RNA biosynthetic process
VT48_15665	COG1174	glycine betaine transport
VT48_15670	COG1732	Glycine betaine
VT48_15675	COG1174	glycine betaine transport
VT48_15680	COG0517	IMP dehydrogenase activity
VT48_15680	COG1125	glycine betaine transport
VT48_15685	COG1510	regulation of RNA biosynthetic process
VT48_15690	COG2095	MarC family integral membrane protein
VT48_15700	COG0456	acetyltransferase
VT48_15720	COG1131	(ABC) transporter
VT48_15730	COG0148	phosphopyruvate hydratase activity
VT48_15735	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
VT48_15740	COG0149	triose-phosphate isomerase activity
VT48_15745	COG0126	phosphoglycerate kinase activity
VT48_15750	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
VT48_15755	COG2390	Transcriptional regulator
VT48_15760	COG0833	amino acid
VT48_15765	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
VT48_15770	COG3829	transcription factor binding
VT48_15775	COG2186	Transcriptional regulator
VT48_15780	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
VT48_15790	COG0534	Mate efflux family protein
VT48_15795	COG4608	Belongs to the ABC transporter superfamily
VT48_15800	COG0444	Belongs to the ABC transporter superfamily
VT48_15805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
VT48_15810	COG0601	transmembrane transport
VT48_15815	COG0747	negative chemotaxis
VT48_15820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VT48_15825	COG0110	maltose O-acetyltransferase activity
VT48_15830	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
VT48_15835	COG2244	polysaccharide biosynthetic process
VT48_15840	COG5039	Polysaccharide pyruvyl transferase
VT48_15845	COG1216	Glycosyl transferase, family 2
VT48_15855	COG0438	transferase activity, transferring glycosyl groups
VT48_15860	COG1215	transferase activity, transferring glycosyl groups
VT48_15865	COG0438	transferase activity, transferring glycosyl groups
VT48_15870	COG1086	Polysaccharide biosynthesis protein
VT48_15875	COG0489	protein tyrosine kinase activity
VT48_15880	COG3944	biosynthesis protein
VT48_15885	COG1396	sequence-specific DNA binding
VT48_15895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_15900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_15910	COG0726	polysaccharide deacetylase
VT48_15920	COG1819	glycosyl
VT48_15925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_15940	COG0740	serine-type endopeptidase activity
VT48_15945	COG1611	Belongs to the LOG family
VT48_15950	COG1694	Mazg nucleotide pyrophosphohydrolase
VT48_15955	COG0659	secondary active sulfate transmembrane transporter activity
VT48_15960	COG0288	reversible hydration of carbon dioxide
VT48_15965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
VT48_15975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
VT48_15980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_15985	COG1481	regulation of sporulation
VT48_15990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
VT48_15995	COG1660	Displays ATPase and GTPase activities
VT48_16000	COG1051	belongs to the nudix hydrolase family
VT48_16005	COG0492	ferredoxin-NADP+ reductase activity
VT48_16010	COG0791	NLP P60 protein
VT48_16010	COG3883	PFAM NLP P60 protein
VT48_16015	COG0457	Tetratricopeptide repeat
VT48_16020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
VT48_16020	COG0140	phosphoribosyl-ATP diphosphatase activity
VT48_16025	COG0107	imidazoleglycerol-phosphate synthase activity
VT48_16030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
VT48_16035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
VT48_16040	COG0131	Imidazoleglycerol-phosphate dehydratase
VT48_16045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
VT48_16050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
VT48_16055	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
VT48_16060	COG4990	cell redox homeostasis
VT48_16070	COG2910	NAD(P)H-binding
VT48_16075	COG1959	2 iron, 2 sulfur cluster binding
VT48_16080	COG0110	maltose O-acetyltransferase activity
VT48_16085	COG0546	phosphoglycolate phosphatase activity
VT48_16090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
VT48_16095	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
VT48_16100	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
VT48_16105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
VT48_16110	COG0363	glucosamine-6-phosphate deaminase activity
VT48_16120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
VT48_16125	COG1950	PFAM Membrane protein of
VT48_16130	COG1983	PspC domain protein
VT48_16135	COG3595	metallopeptidase activity
VT48_16150	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
VT48_16160	COG4897	Protein conserved in bacteria
VT48_16165	COG0574	Belongs to the PEP-utilizing enzyme family
VT48_16165	COG3848	Pyruvate phosphate dikinase
VT48_16170	COG1309	transcriptional regulator
VT48_16175	COG2814	Major facilitator Superfamily
VT48_16185	COG0745	RESPONSE REGULATOR receiver
VT48_16190	COG5002	protein histidine kinase activity
VT48_16195	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
VT48_16200	COG0463	Glycosyl transferase, family 2
VT48_16205	COG1113	amino acid transport
VT48_16210	COG0778	Nitroreductase
VT48_16215	COG1733	regulation of RNA biosynthetic process
VT48_16220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VT48_16230	COG3409	Peptidoglycan-binding domain 1 protein
VT48_16230	COG0793	Belongs to the peptidase S41A family
VT48_16235	COG0730	response to heat
VT48_16240	COG3883	PFAM NLP P60 protein
VT48_16240	COG0791	NLP P60 protein
VT48_16245	COG2177	Part of the ABC transporter FtsEX involved in
VT48_16250	COG2884	Cell division ATP-binding protein ftsE
VT48_16255	COG2010	Cytochrome c
VT48_16260	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
VT48_16275	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
VT48_16280	COG0653	protein targeting
VT48_16285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
VT48_16290	COG0840	transmembrane signaling receptor activity
VT48_16305	COG1516	flagellar protein fliS
VT48_16310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
VT48_16315	COG1334	flagellar protein FlaG
VT48_16320	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
VT48_16325	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
VT48_16335	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
VT48_16340	COG4786	Flagellar basal body rod
VT48_16340	COG1256	bacterial-type flagellum assembly
VT48_16345	COG3418	PFAM FlgN family protein
VT48_16360	COG1040	competence protein
VT48_16370	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
VT48_16375	COG1307	EDD domain protein, DegV family
VT48_16380	COG2197	response regulator
VT48_16385	COG4585	Histidine kinase
VT48_16390	COG1739	Uncharacterized protein family UPF0029
VT48_16395	COG1316	TRANSCRIPTIONal
VT48_16400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
VT48_16405	COG0438	transferase activity, transferring glycosyl groups
VT48_16410	COG1215	transferase activity, transferring glycosyl groups
VT48_16415	COG3206	protein involved in exopolysaccharide biosynthesis
VT48_16420	COG3307	-O-antigen
VT48_16425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
VT48_16430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VT48_16435	COG0438	transferase activity, transferring glycosyl groups
VT48_16435	COG0297	glycogen (starch) synthase activity
VT48_16440	COG2244	polysaccharide biosynthetic process
VT48_16455	COG0860	N-Acetylmuramoyl-L-alanine amidase
VT48_16455	COG2247	cell wall binding repeat
VT48_16460	COG2247	cell wall binding repeat
VT48_16460	COG0860	N-Acetylmuramoyl-L-alanine amidase
VT48_16465	COG2385	sporulation resulting in formation of a cellular spore
VT48_16465	COG2247	cell wall binding repeat
VT48_16475	COG1316	TRANSCRIPTIONal
VT48_16480	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
VT48_16485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
VT48_16490	COG1134	teichoic acid transport
VT48_16495	COG1682	transport, permease protein
VT48_16505	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
VT48_16515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
VT48_16520	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
VT48_16525	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
VT48_16530	COG4193	domain, Protein
VT48_16535	COG1482	cell wall glycoprotein biosynthetic process
VT48_16545	COG1175	transmembrane transport
VT48_16550	COG1653	transport
VT48_16555	COG2197	response regulator
VT48_16560	COG2972	Histidine kinase
VT48_16570	COG0454	-acetyltransferase
VT48_16575	COG0800	Aldolase
VT48_16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VT48_16585	COG1609	Transcriptional regulator
VT48_16590	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
VT48_16595	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_16600	COG0697	spore germination
VT48_16605	COG0814	amino acid
VT48_16620	COG2814	Major facilitator Superfamily
VT48_16625	COG1316	TRANSCRIPTIONal
VT48_16630	COG0561	phosphatase activity
VT48_16635	COG0791	NLP P60 protein
VT48_16640	COG2843	Capsule synthesis protein
VT48_16650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
VT48_16655	COG0697	spore germination
VT48_16670	COG1609	Transcriptional regulator
VT48_16675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
VT48_16680	COG1869	D-ribose catabolic process
VT48_16685	COG1129	ABC transporter
VT48_16690	COG1172	Belongs to the binding-protein-dependent transport system permease family
VT48_16695	COG1879	ABC-type sugar transport system periplasmic component
VT48_16700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
VT48_16705	COG0583	DNA-binding transcription factor activity
VT48_16710	COG0028	Belongs to the TPP enzyme family
VT48_16715	COG3527	Alpha-acetolactate decarboxylase
VT48_16720	COG1522	sequence-specific DNA binding
VT48_16725	COG2059	Chromate
VT48_16730	COG2059	Chromate
VT48_16735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
VT48_16740	COG4715	Zinc finger, swim domain protein
VT48_16745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
VT48_16750	COG2202	Pas domain
VT48_16750	COG1366	Belongs to the anti-sigma-factor antagonist family
VT48_16755	COG0561	phosphatase activity
VT48_16770	COG1970	mechanosensitive ion channel activity
VT48_16775	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
VT48_16780	COG0457	Tetratricopeptide repeat
VT48_16785	COG4786	Flagellar basal body rod
VT48_16790	COG4786	Flagellar basal body rod
VT48_16795	COG1077	Cell shape determining protein MreB Mrl
VT48_16800	COG1609	Transcriptional regulator
VT48_16805	COG1846	Transcriptional regulator
VT48_16810	COG2814	Major facilitator Superfamily
VT48_16815	COG0671	phosphoesterase, PA-phosphatase related
VT48_16820	COG0477	Major facilitator Superfamily
VT48_16825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_16830	COG0765	amino acid transport
VT48_16835	COG1126	abc transporter atp-binding protein
VT48_16840	COG0004	ammonium transporteR
VT48_16845	COG0347	Belongs to the P(II) protein family
VT48_16850	COG0739	heme binding
VT48_16855	COG1247	-acetyltransferase
VT48_16890	COG0267	Belongs to the bacterial ribosomal protein bL33 family
VT48_16895	COG0523	cobalamin synthesis protein
VT48_16900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
VT48_16905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
VT48_16910	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
VT48_16925	COG2304	oxidoreductase activity
VT48_16930	COG2304	oxidoreductase activity
VT48_16935	COG2385	sporulation resulting in formation of a cellular spore
VT48_16940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VT48_16950	COG4836	Membrane
VT48_16960	COG0355	proton-transporting ATP synthase activity, rotational mechanism
VT48_16965	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
VT48_16970	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
VT48_16975	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
VT48_16980	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VT48_16985	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
VT48_16990	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
VT48_16995	COG0356	it plays a direct role in the translocation of protons across the membrane
VT48_17005	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
VT48_17010	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
VT48_17015	COG4475	Protein of unknown function (DUF436)
VT48_17020	COG0698	ribose 5-phosphate isomerase
VT48_17025	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
VT48_17030	COG1971	Probably functions as a manganese efflux pump
VT48_17035	COG0009	L-threonylcarbamoyladenylate synthase
VT48_17040	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
VT48_17055	COG2890	protein-(glutamine-N5) methyltransferase activity
VT48_17060	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
VT48_17065	COG0789	Transcriptional regulator
VT48_17070	COG0679	Auxin Efflux Carrier
VT48_17075	COG0281	malic enzyme
VT48_17080	COG1435	thymidine kinase activity
VT48_17085	COG0254	rRNA binding
VT48_17090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
VT48_17095	COG1494	fructose-1,6-bisphosphatase
VT48_17100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
VT48_17105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
VT48_17110	COG0191	fructose-bisphosphate aldolase activity
VT48_17115	COG2204	response regulator
VT48_17120	COG4821	SIS domain
VT48_17125	COG0504	CTP synthase activity
VT48_17130	COG3343	RNA polymerase activity
VT48_17145	COG1960	acyl-CoA dehydrogenase activity
VT48_17150	COG1960	acyl-CoA dehydrogenase activity
VT48_17155	COG1250	3-hydroxyacyl-CoA dehydrogenase
VT48_17160	COG0183	Belongs to the thiolase family
VT48_17165	COG0247	lactate metabolic process
VT48_17165	COG2181	nitrate reductase activity
VT48_17170	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VT48_17175	COG4294	response to UV
VT48_17185	COG1619	proteins homologs of microcin C7 resistance protein MccF
VT48_17195	COG1132	(ABC) transporter
VT48_17200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
VT48_17205	COG1619	proteins homologs of microcin C7 resistance protein MccF
VT48_17215	COG0018	arginyl-trna synthetase
VT48_17220	COG4506	Protein conserved in bacteria
VT48_17230	COG0010	Belongs to the arginase family
VT48_17235	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
VT48_17240	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
VT48_17250	COG1994	Peptidase M50
VT48_17255	COG1942	4-Oxalocrotonate Tautomerase
VT48_17265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VT48_17270	COG0583	DNA-binding transcription factor activity
VT48_17275	COG0431	NADPH-dependent FMN reductase
VT48_17280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VT48_17285	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
VT48_17290	COG0454	-acetyltransferase
VT48_17295	COG0765	amino acid transport
VT48_17305	COG0765	amino acid transport
VT48_17310	COG1126	abc transporter atp-binding protein
VT48_17315	COG3465	dGTPase activity
VT48_17320	COG1078	dGTPase activity
VT48_17325	COG4844	belongs to the
VT48_17375	COG5444	nuclease activity
VT48_17405	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
VT48_17415	COG0280	phosphate acetyltransferase
VT48_17425	COG2814	Major facilitator Superfamily
VT48_17430	COG1522	sequence-specific DNA binding
VT48_17435	COG2814	Major facilitator Superfamily
VT48_17440	COG0077	Prephenate dehydratase
VT48_17445	COG1917	Cupin 2, conserved barrel domain protein
VT48_17450	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_17455	COG0151	Belongs to the GarS family
VT48_17460	COG0436	Aminotransferase
VT48_17465	COG1028	Short-chain dehydrogenase reductase Sdr
VT48_17470	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
VT48_17475	COG1091	dTDP-4-dehydrorhamnose reductase activity
VT48_17480	COG1088	dTDP-glucose 4,6-dehydratase activity
VT48_17485	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
VT48_17490	COG3980	spore coat polysaccharide biosynthesis protein
VT48_17495	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
VT48_17500	COG2089	acid synthase
VT48_17505	COG0456	acetyltransferase
VT48_17510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
VT48_17515	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
VT48_17520	COG0463	Glycosyl transferase, family 2
VT48_17540	COG2363	Small membrane protein
VT48_17545	COG2233	PERMEase
VT48_17555	COG1012	belongs to the aldehyde dehydrogenase family
VT48_17560	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
VT48_17565	COG1216	Glycosyl transferase, family 2
VT48_17575	COG0351	phosphomethylpyrimidine kinase
VT48_17590	COG1621	beta-fructofuranosidase activity
VT48_17595	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_17595	COG1263	PTS System
VT48_17600	COG3711	transcriptional antiterminator
VT48_17610	COG1404	Belongs to the peptidase S8 family
VT48_17620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
VT48_17625	COG0778	Nitroreductase
VT48_17630	COG0772	Belongs to the SEDS family
VT48_17640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
VT48_17645	COG1845	cytochrome c oxidase, subunit III
VT48_17650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
VT48_17655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
VT48_17665	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
VT48_17670	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
VT48_17675	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
VT48_17690	COG2246	polysaccharide biosynthetic process
VT48_17720	COG0457	Tetratricopeptide repeat
VT48_17735	COG3162	membrane
VT48_17740	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
VT48_17755	COG0352	thiamine-phosphate diphosphorylase activity
VT48_17760	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
VT48_17765	COG0583	DNA-binding transcription factor activity
VT48_17770	COG1380	Effector of murein hydrolase LrgA
VT48_17775	COG1346	cytolysis
VT48_17780	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
VT48_17785	COG0346	lactoylglutathione lyase activity
VT48_17795	COG0765	amino acid transport
VT48_17800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
VT48_17805	COG0457	Tetratricopeptide repeat
VT48_17810	COG2357	RelA SpoT domain protein
VT48_17815	COG1172	Belongs to the binding-protein-dependent transport system permease family
VT48_17820	COG1129	ABC transporter
VT48_17830	COG3420	alginic acid biosynthetic process
VT48_17835	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
VT48_17850	COG1486	melibiose metabolic process
VT48_17855	COG1447	Phosphotransferase system cellobiose-specific component IIA
VT48_17860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VT48_17865	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VT48_17870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_17870	COG3711	transcriptional antiterminator
VT48_17885	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
VT48_17900	COG1595	DNA-templated transcription, initiation
VT48_17905	COG3866	Pectate lyase
VT48_17910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
VT48_17915	COG4988	ABC transporter
VT48_17920	COG1294	oxidase, subunit
VT48_17925	COG1271	oxidase subunit
VT48_17930	COG1120	ATPase activity
VT48_17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
VT48_17940	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
VT48_17945	COG4509	Sortase family
VT48_17970	COG5386	Cell surface protein
VT48_17975	COG5386	Cell surface protein
VT48_17980	COG1733	regulation of RNA biosynthetic process
VT48_17985	COG2514	catechol 2,3-dioxygenase activity
VT48_17990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VT48_17990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
VT48_17995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VT48_17995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
VT48_18000	COG0346	lactoylglutathione lyase activity
VT48_18005	COG0726	polysaccharide deacetylase
VT48_18010	COG1447	Phosphotransferase system cellobiose-specific component IIA
VT48_18015	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VT48_18020	COG2723	6-phospho-beta-galactosidase activity
VT48_18025	COG1312	Catalyzes the dehydration of D-mannonate
VT48_18030	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
VT48_18035	COG3711	transcriptional antiterminator
VT48_18035	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
VT48_18060	COG1757	Na H antiporter
VT48_18065	COG1027	Aspartate ammonia-lyase
VT48_18070	COG0252	asparaginase activity
VT48_18075	COG1396	sequence-specific DNA binding
VT48_18100	COG4842	Belongs to the WXG100 family
VT48_18105	COG2195	Cleaves the N-terminal amino acid of tripeptides
VT48_18120	COG1737	Transcriptional regulator
VT48_18125	COG2084	Dehydrogenase
VT48_18135	COG2610	gluconate transmembrane transporter activity
VT48_18140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
VT48_18145	COG2723	6-phospho-beta-galactosidase activity
VT48_18150	COG2190	(PTS) system
VT48_18150	COG1263	PTS System
VT48_18150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_18155	COG3711	transcriptional antiterminator
VT48_18160	COG3878	Protein conserved in bacteria
VT48_18170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VT48_18175	COG1122	ATPase activity
VT48_18180	COG4721	ABC-type cobalt transport system, permease component
VT48_18185	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
VT48_18210	COG3291	Pkd domain containing protein
VT48_18210	COG4412	M6 family metalloprotease domain protein
VT48_18215	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
VT48_18220	COG0778	Nitroreductase
VT48_18225	COG1846	Transcriptional regulator
VT48_18230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
VT48_18235	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
VT48_18240	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
VT48_18245	COG2390	Transcriptional regulator
VT48_18255	COG2755	lipolytic protein G-D-S-L family
VT48_18255	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
VT48_18260	COG0477	Major facilitator Superfamily
VT48_18265	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
VT48_18270	COG2226	methyltransferase
VT48_18280	COG0561	phosphatase activity
VT48_18285	COG0789	Transcriptional regulator
VT48_18290	COG0673	inositol 2-dehydrogenase activity
VT48_18295	COG0840	transmembrane signaling receptor activity
VT48_18300	COG1113	amino acid transport
VT48_18305	COG4335	DNA alkylation repair
VT48_18315	COG1070	Carbohydrate kinase
VT48_18320	COG1737	Transcriptional regulator
VT48_18360	COG0583	DNA-binding transcription factor activity
VT48_18365	COG1609	Transcriptional regulator
VT48_18370	COG2182	Extracellular solute-binding protein
VT48_18375	COG1175	transmembrane transport
VT48_18380	COG3833	ABC-type maltose transport systems, permease component
VT48_18390	COG1874	Beta-galactosidase
VT48_18395	COG2851	Citrate transporter
VT48_18405	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
VT48_18410	COG1131	(ABC) transporter
VT48_18415	COG2824	Alkylphosphonate utilization operon protein PhnA
VT48_18420	COG1929	Belongs to the glycerate kinase type-1 family
VT48_18425	COG2610	gluconate transmembrane transporter activity
VT48_18430	COG3835	regulator
VT48_18435	COG1309	transcriptional regulator
VT48_18440	COG2814	Major facilitator Superfamily
VT48_18450	COG1136	(ABC) transporter
VT48_18460	COG0457	Tetratricopeptide repeat
VT48_18465	COG3711	transcriptional antiterminator
VT48_18470	COG2723	6-phospho-beta-galactosidase activity
VT48_18475	COG2190	(PTS) system
VT48_18475	COG1263	PTS System
VT48_18475	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_18500	COG0494	nUDIX hydrolase
VT48_18515	COG1113	amino acid transport
VT48_18525	COG2814	Major facilitator Superfamily
VT48_18530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
VT48_18535	COG2814	Major facilitator Superfamily
VT48_18540	COG2723	6-phospho-beta-galactosidase activity
VT48_18550	COG1263	PTS System
VT48_18550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_18550	COG2190	(PTS) system
VT48_18595	COG2723	6-phospho-beta-galactosidase activity
VT48_18600	COG1263	PTS System
VT48_18600	COG2190	(PTS) system
VT48_18600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
VT48_18605	COG2188	Transcriptional regulator
VT48_18620	COG0384	phenazine biosynthesis protein PhzF
VT48_18625	COG0583	DNA-binding transcription factor activity
VT48_18645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
VT48_18660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
VT48_18670	COG1401	restriction endodeoxyribonuclease activity
VT48_18700	COG0641	radical SAM
VT48_18705	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
VT48_18710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
VT48_18720	COG4720	Psort location CytoplasmicMembrane, score
VT48_18740	COG0456	acetyltransferase
VT48_18745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
VT48_18750	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
VT48_18755	COG4853	Protein conserved in bacteria
VT48_18760	COG4863	YycH protein
VT48_18765	COG5002	protein histidine kinase activity
VT48_18770	COG0745	RESPONSE REGULATOR receiver
VT48_18795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
VT48_18805	COG2311	Membrane
VT48_18810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
VT48_18815	COG1309	transcriptional regulator
VT48_18820	COG2124	cytochrome p450
VT48_18825	COG0346	lactoylglutathione lyase activity
VT48_18830	COG0305	Participates in initiation and elongation during chromosome replication
VT48_18845	COG2819	hydrolase of the alpha beta superfamily
VT48_18850	COG2207	Transcriptional regulator
VT48_18850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_18855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
VT48_18860	COG2819	hydrolase of the alpha beta superfamily
VT48_18865	COG2807	transmembrane transport
VT48_18870	COG0359	binds to the 23S rRNA
VT48_18875	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
VT48_18880	COG4241	membrane
VT48_18885	COG1227	inorganic diphosphatase activity
VT48_18895	COG1595	DNA-templated transcription, initiation
VT48_18905	COG0753	catalase activity
VT48_18910	COG0655	NAD(P)H dehydrogenase (quinone) activity
VT48_18915	COG0400	carboxylic ester hydrolase activity
VT48_18920	COG0346	lactoylglutathione lyase activity
VT48_18925	COG1174	glycine betaine transport
VT48_18930	COG0517	IMP dehydrogenase activity
VT48_18930	COG1125	glycine betaine transport
VT48_18935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
VT48_18940	COG0629	single-stranded DNA binding
VT48_18945	COG0360	Binds together with S18 to 16S ribosomal RNA
VT48_18950	COG0012	GTP binding
VT48_18955	COG4481	Protein conserved in bacteria
VT48_18970	COG3949	Membrane
VT48_18980	COG1475	DNA binding
VT48_18985	COG1192	Involved in chromosome partitioning
VT48_18995	COG1475	DNA binding
VT48_19000	COG0357	Ribosomal RNA small subunit methyltransferase G
VT48_19005	COG0445	tRNA wobble uridine modification
VT48_19010	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
VT48_19015	COG1847	R3H domain protein
VT48_19020	COG0706	membrane insertase activity
VT48_19025	COG0594	ribonuclease P activity