locus-tag	class	description
M5E03_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E03_00010	COG0592	DNA-directed DNA polymerase activity
M5E03_00015	COG2501	S4 domain
M5E03_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5E03_00030	COG0187	DNA topoisomerase II activity
M5E03_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5E03_00070	COG0516	GMP reductase activity
M5E03_00070	COG0517	IMP dehydrogenase activity
M5E03_00075	COG1686	Belongs to the peptidase S11 family
M5E03_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M5E03_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M5E03_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5E03_00110	COG1428	Deoxynucleoside kinase
M5E03_00115	COG1428	Deoxynucleoside kinase
M5E03_00120	COG3858	chitin binding
M5E03_00120	COG1388	LysM domain
M5E03_00125	COG1335	isochorismatase
M5E03_00130	COG0590	tRNA wobble adenosine to inosine editing
M5E03_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5E03_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M5E03_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5E03_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M5E03_00200	COG3853	Toxic anion resistance protein (TelA)
M5E03_00205	COG1982	Orn Lys Arg decarboxylase major
M5E03_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M5E03_00215	COG3870	Protein conserved in bacteria
M5E03_00220	COG1728	Protein conserved in bacteria
M5E03_00225	COG0470	DNA polymerase III
M5E03_00230	COG1774	PSP1 C-terminal conserved region
M5E03_00235	COG4467	Involved in initiation control of chromosome replication
M5E03_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M5E03_00245	COG2827	Endonuclease containing a URI domain
M5E03_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M5E03_00255	COG2002	toxin-antitoxin pair type II binding
M5E03_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_00265	COG0084	hydrolase, TatD family'
M5E03_00280	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5E03_00285	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5E03_00295	COG4466	Protein conserved in bacteria
M5E03_00305	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M5E03_00310	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E03_00315	COG0251	oxidation-reduction process
M5E03_00320	COG2088	sporulation resulting in formation of a cellular spore
M5E03_00330	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5E03_00335	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M5E03_00340	COG0193	aminoacyl-tRNA hydrolase activity
M5E03_00350	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5E03_00355	COG2002	toxin-antitoxin pair type II binding
M5E03_00360	COG2244	polysaccharide biosynthetic process
M5E03_00365	COG3956	TIGRFAM MazG family protein
M5E03_00370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5E03_00385	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M5E03_00390	COG1098	S1 RNA binding domain
M5E03_00405	COG2208	phosphoserine phosphatase activity
M5E03_00410	COG2304	oxidoreductase activity
M5E03_00415	COG0515	serine threonine protein kinase
M5E03_00420	COG0037	tRNA processing
M5E03_00425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M5E03_00430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E03_00435	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M5E03_00440	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5E03_00445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E03_00450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_00455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5E03_00460	COG0512	Glutamine amidotransferase of anthranilate synthase
M5E03_00465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_00470	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5E03_00475	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5E03_00480	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5E03_00485	COG1396	sequence-specific DNA binding
M5E03_00490	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E03_00495	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5E03_00575	COG4463	regulation of RNA biosynthetic process
M5E03_00580	COG3880	PFAM UvrB UvrC protein
M5E03_00585	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M5E03_00590	COG0542	response to heat
M5E03_00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5E03_00600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M5E03_00605	COG4956	integral membrane protein (PIN domain superfamily)
M5E03_00610	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5E03_00615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M5E03_00620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E03_00625	COG1045	serine acetyltransferase
M5E03_00630	COG0215	cysteine-tRNA ligase activity
M5E03_00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M5E03_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E03_00645	COG3688	RNA-binding protein containing a PIN domain
M5E03_00650	COG1595	DNA-templated transcription, initiation
M5E03_00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E03_00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E03_00665	COG0250	Participates in transcription elongation, termination and antitermination
M5E03_00675	COG0081	regulation of translation
M5E03_00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5E03_00685	COG0222	ribosome binding
M5E03_00690	COG2813	Specifically methylates the guanine in position
M5E03_00695	COG0085	RNA polymerase activity
M5E03_00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M5E03_00705	COG1358	cellular component organization or biogenesis
M5E03_00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M5E03_00715	COG0049	tRNA binding
M5E03_00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5E03_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E03_00730	COG0596	Alpha beta hydrolase
M5E03_00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M5E03_00745	COG0088	Forms part of the polypeptide exit tunnel
M5E03_00750	COG0089	rRNA binding
M5E03_00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M5E03_00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5E03_00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M5E03_00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M5E03_00780	COG0255	Belongs to the universal ribosomal protein uL29 family
M5E03_00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M5E03_00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M5E03_00795	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M5E03_00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M5E03_00805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5E03_00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5E03_00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5E03_00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M5E03_00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M5E03_00830	COG1841	ribosomal large subunit assembly
M5E03_00835	COG0200	Binds to the 23S rRNA
M5E03_00840	COG0201	protein transport
M5E03_00845	COG0563	adenylate kinase activity
M5E03_00850	COG0024	Methionine aminopeptidase
M5E03_00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M5E03_00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5E03_00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5E03_00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M5E03_00880	COG0202	RNA polymerase activity
M5E03_00885	COG0203	ribosomal protein L17
M5E03_00890	COG1122	ATPase activity
M5E03_00895	COG1122	ATPase activity
M5E03_00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E03_00905	COG0101	tRNA pseudouridine synthase activity
M5E03_00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5E03_00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5E03_00960	COG2189	Belongs to the N(4) N(6)-methyltransferase family
M5E03_00965	COG3421	Type III restriction
M5E03_00975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_01000	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_01005	COG0489	protein tyrosine kinase activity
M5E03_01015	COG2194	sulfuric ester hydrolase activity
M5E03_01020	COG0726	polysaccharide deacetylase
M5E03_01050	COG0659	secondary active sulfate transmembrane transporter activity
M5E03_01055	COG0385	Bile acid
M5E03_01060	COG3876	Protein conserved in bacteria
M5E03_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
M5E03_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5E03_01075	COG1263	PTS System
M5E03_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_01080	COG1737	Transcriptional regulator
M5E03_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5E03_01120	COG1595	DNA-templated transcription, initiation
M5E03_01125	COG5662	AntiSigma factor
M5E03_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5E03_01135	COG4856	YbbR-like protein
M5E03_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E03_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5E03_01165	COG1131	(ABC) transporter
M5E03_01180	COG1131	(ABC) transporter
M5E03_01190	COG1413	lyase activity
M5E03_01220	COG2311	Membrane
M5E03_01240	COG1113	amino acid transport
M5E03_01245	COG0584	glycerophosphoryl diester phosphodiesterase
M5E03_01250	COG2271	Major facilitator Superfamily
M5E03_01260	COG1331	Highly conserved protein containing a thioredoxin domain
M5E03_01285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E03_01295	COG1331	Highly conserved protein containing a thioredoxin domain
M5E03_01310	COG1937	Protein conserved in bacteria
M5E03_01315	COG2210	Belongs to the sulfur carrier protein TusA family
M5E03_01325	COG0425	Belongs to the sulfur carrier protein TusA family
M5E03_01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_01330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_01330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_01335	COG0425	Belongs to the sulfur carrier protein TusA family
M5E03_01340	COG0730	response to heat
M5E03_01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E03_01355	COG2814	Major facilitator Superfamily
M5E03_01365	COG1846	Transcriptional regulator
M5E03_01375	COG1683	Conserved Protein
M5E03_01385	COG0656	L-ascorbic acid biosynthetic process
M5E03_01390	COG0371	Dehydrogenase
M5E03_01395	COG1054	Belongs to the UPF0176 family
M5E03_01400	COG0531	amino acid
M5E03_01410	COG3711	transcriptional antiterminator
M5E03_01415	COG1263	PTS System
M5E03_01415	COG2190	(PTS) system
M5E03_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_01420	COG2723	6-phospho-beta-galactosidase activity
M5E03_01440	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_01440	COG3711	transcriptional antiterminator
M5E03_01445	COG1940	carbohydrate kinase activity
M5E03_01450	COG0383	alpha-mannosidase activity
M5E03_01455	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_01460	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_01470	COG1404	Belongs to the peptidase S8 family
M5E03_01485	COG0833	amino acid
M5E03_01490	COG2040	homocysteine
M5E03_01495	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_01500	COG1695	Transcriptional regulator
M5E03_01515	COG2814	Major facilitator Superfamily
M5E03_01520	COG0456	acetyltransferase
M5E03_01535	COG1404	Belongs to the peptidase S8 family
M5E03_01545	COG1309	transcriptional regulator
M5E03_01550	COG1917	Cupin 2, conserved barrel domain protein
M5E03_01555	COG1063	alcohol dehydrogenase
M5E03_01560	COG1846	Transcriptional regulator
M5E03_01565	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_01570	COG0531	amino acid
M5E03_01580	COG0596	Alpha beta hydrolase
M5E03_01585	COG1115	amino acid carrier protein
M5E03_01590	COG2066	Belongs to the glutaminase family
M5E03_01595	COG4191	Histidine kinase
M5E03_01600	COG0784	Response regulator, receiver
M5E03_01605	COG1405	negative regulation of cell septum assembly
M5E03_01605	COG3012	SEC-C Motif Domain Protein
M5E03_01615	COG2197	response regulator
M5E03_01620	COG4585	Histidine kinase
M5E03_01630	COG0667	Aldo Keto reductase
M5E03_01635	COG3290	protein histidine kinase activity
M5E03_01640	COG3279	Response regulator of the LytR AlgR family
M5E03_01645	COG4555	ABC transporter
M5E03_01650	COG1668	transmembrane transport
M5E03_01660	COG3773	Cell wall hydrolase
M5E03_01665	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_01680	COG2310	stress, protein
M5E03_01685	COG2310	stress, protein
M5E03_01690	COG2310	stress, protein
M5E03_01695	COG0861	Integral membrane protein TerC family
M5E03_01725	COG3853	Toxic anion resistance protein (TelA)
M5E03_01730	COG0517	IMP dehydrogenase activity
M5E03_01730	COG4175	Glycine betaine
M5E03_01735	COG4176	ABC-type proline glycine betaine transport system permease component
M5E03_01740	COG2113	Glycine betaine
M5E03_01745	COG0596	Alpha beta hydrolase
M5E03_01755	COG1473	amidohydrolase
M5E03_01760	COG1288	antiporter activity
M5E03_01765	COG0039	L-malate dehydrogenase activity
M5E03_01770	COG1620	l-lactate permease
M5E03_01775	COG1609	Transcriptional regulator
M5E03_01780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E03_01785	COG0561	phosphatase activity
M5E03_01790	COG0673	inositol 2-dehydrogenase activity
M5E03_01795	COG0738	Major facilitator superfamily
M5E03_01800	COG1280	lysine exporter protein (LysE YggA)
M5E03_01810	COG3403	YqcI/YcgG family
M5E03_01815	COG1113	amino acid transport
M5E03_01820	COG3665	Urea carboxylase-associated protein
M5E03_01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5E03_01835	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_01840	COG0710	3-dehydroquinate dehydratase activity
M5E03_01845	COG0028	Belongs to the TPP enzyme family
M5E03_01855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E03_01875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5E03_01880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E03_01890	COG0477	Major facilitator Superfamily
M5E03_01895	COG2226	methyltransferase
M5E03_01900	COG0583	DNA-binding transcription factor activity
M5E03_01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E03_01910	COG3458	cephalosporin-C deacetylase activity
M5E03_01920	COG3541	Predicted nucleotidyltransferase
M5E03_01925	COG0506	proline dehydrogenase activity
M5E03_01930	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_01935	COG2508	Transcriptional regulator
M5E03_01940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M5E03_01945	COG0765	amino acid transport
M5E03_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_01960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E03_01965	COG1522	sequence-specific DNA binding
M5E03_01970	COG2746	aminoglycoside 3-N-acetyltransferase activity
M5E03_01980	COG0840	transmembrane signaling receptor activity
M5E03_01980	COG3290	protein histidine kinase activity
M5E03_01985	COG3209	COG3209 Rhs family protein
M5E03_02005	COG3842	ATPase activity
M5E03_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M5E03_02060	COG4555	ABC transporter
M5E03_02075	COG0697	spore germination
M5E03_02080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_02095	COG2364	Membrane
M5E03_02100	COG0737	Belongs to the 5'-nucleotidase family
M5E03_02105	COG3764	Sortase (surface protein transpeptidase)
M5E03_02110	COG2002	toxin-antitoxin pair type II binding
M5E03_02115	COG1126	abc transporter atp-binding protein
M5E03_02120	COG0765	amino acid transport
M5E03_02125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_02130	COG0412	Dienelactone hydrolase
M5E03_02135	COG0833	amino acid
M5E03_02140	COG3104	oligopeptide transport
M5E03_02145	COG5434	Belongs to the glycosyl hydrolase 28 family
M5E03_02150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_02155	COG0456	acetyltransferase
M5E03_02160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_02165	COG0765	amino acid transport
M5E03_02170	COG1126	abc transporter atp-binding protein
M5E03_02175	COG1473	amidohydrolase
M5E03_02180	COG2079	MmgE PrpD family protein
M5E03_02185	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_02190	COG0527	aspartate kinase activity
M5E03_02195	COG2814	Major facilitator Superfamily
M5E03_02200	COG1309	transcriptional regulator
M5E03_02210	COG0640	Transcriptional regulator
M5E03_02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_02220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E03_02225	COG0531	amino acid
M5E03_02230	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_02235	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E03_02240	COG4549	nuclear export factor GLE1
M5E03_02245	COG2372	response to copper ion
M5E03_02245	COG1276	copper resistance
M5E03_02250	COG2213	PTS system mannitol-specific
M5E03_02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_02260	COG0246	Mannitol dehydrogenase
M5E03_02265	COG0840	transmembrane signaling receptor activity
M5E03_02285	COG0346	lactoylglutathione lyase activity
M5E03_02295	COG0561	phosphatase activity
M5E03_02300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M5E03_02305	COG1914	H( )-stimulated, divalent metal cation uptake system
M5E03_02310	COG4336	lyase activity
M5E03_02315	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M5E03_02320	COG1984	allophanate hydrolase subunit 2
M5E03_02325	COG1414	Transcriptional regulator
M5E03_02330	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5E03_02335	COG2755	lipolytic protein G-D-S-L family
M5E03_02345	COG3711	transcriptional antiterminator
M5E03_02350	COG2226	methyltransferase
M5E03_02355	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_02360	COG3871	stress protein (general stress protein 26)
M5E03_02380	COG2814	Major facilitator Superfamily
M5E03_02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5E03_02390	COG0551	DNA topoisomerase type I activity
M5E03_02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M5E03_02405	COG3706	GGDEF domain
M5E03_02410	COG5298	Protein conserved in bacteria
M5E03_02415	COG1215	transferase activity, transferring glycosyl groups
M5E03_02425	COG0531	amino acid
M5E03_02430	COG0028	Belongs to the TPP enzyme family
M5E03_02435	COG5444	nuclease activity
M5E03_02460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_02465	COG1914	H( )-stimulated, divalent metal cation uptake system
M5E03_02470	COG2261	transglycosylase associated protein
M5E03_02475	COG2217	Heavy metal translocating P-type atpase
M5E03_02480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5E03_02485	COG3290	protein histidine kinase activity
M5E03_02490	COG4565	transcriptional regulatory protein
M5E03_02495	COG1301	dicarboxylic acid transport
M5E03_02500	COG0628	permease
M5E03_02505	COG1301	dicarboxylic acid transport
M5E03_02510	COG1131	(ABC) transporter
M5E03_02515	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5E03_02530	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_02535	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5E03_02540	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5E03_02555	COG0513	Belongs to the DEAD box helicase family
M5E03_02560	COG3402	PFAM membrane-flanked domain
M5E03_02565	COG3428	Bacterial PH domain
M5E03_02570	COG0705	Rhomboid family
M5E03_02575	COG0736	holo-[acyl-carrier-protein] synthase activity
M5E03_02580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5E03_02585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E03_02590	COG0864	Transcriptional regulator
M5E03_02595	COG2337	Toxic component of a toxin-antitoxin (TA) module
M5E03_02600	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_02605	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_02610	COG2172	sigma factor antagonist activity
M5E03_02615	COG2208	phosphoserine phosphatase activity
M5E03_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_02625	COG2172	sigma factor antagonist activity
M5E03_02630	COG1191	sigma factor activity
M5E03_02635	COG2208	phosphoserine phosphatase activity
M5E03_02640	COG2183	response to ionizing radiation
M5E03_02650	COG3091	SprT-like family
M5E03_02655	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_02660	COG0022	dehydrogenase e1 component
M5E03_02665	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_02670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_02675	COG3284	Transcriptional regulator
M5E03_02720	COG1278	Cold shock
M5E03_02725	COG1329	Transcriptional regulator
M5E03_02730	COG1064	alcohol dehydrogenase
M5E03_02735	COG0789	Transcriptional regulator
M5E03_02750	COG0477	Major facilitator Superfamily
M5E03_02755	COG0657	acetylesterase activity
M5E03_02775	COG4221	oxidoreductase activity
M5E03_02790	COG0252	asparaginase activity
M5E03_02810	COG2814	Major facilitator Superfamily
M5E03_02815	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_02845	COG1309	transcriptional regulator
M5E03_02850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5E03_02855	COG1846	Transcriptional regulator
M5E03_02860	COG0778	Nitroreductase
M5E03_02875	COG1396	sequence-specific DNA binding
M5E03_02895	COG4122	O-methyltransferase activity
M5E03_02905	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E03_02910	COG0697	spore germination
M5E03_02920	COG1301	dicarboxylic acid transport
M5E03_02960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5E03_02965	COG0802	atpase or kinase
M5E03_02970	COG1214	PFAM Peptidase M22, glycoprotease
M5E03_02975	COG0456	acetyltransferase
M5E03_02980	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5E03_02985	COG0488	(ABC) transporter
M5E03_02990	COG0315	cyclic pyranopterin monophosphate synthase activity
M5E03_02995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M5E03_03000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5E03_03005	COG0805	protein transport
M5E03_03020	COG1266	CAAX protease self-immunity
M5E03_03025	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M5E03_03030	COG0459	protein refolding
M5E03_03035	COG4974	Belongs to the 'phage' integrase family
M5E03_03040	COG2856	Zn peptidase
M5E03_03050	COG1396	sequence-specific DNA binding
M5E03_03095	COG5377	YqaJ viral recombinase family
M5E03_03100	COG3723	Recombinational DNA repair protein, rece pathway
M5E03_03110	COG1484	DNA-dependent DNA replication
M5E03_03115	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M5E03_03155	COG3677	Transposase
M5E03_03170	COG5484	DNA packaging
M5E03_03275	COG4824	toxin secretion phage lysis holin
M5E03_03280	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_03280	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E03_03305	COG1487	ribonuclease activity
M5E03_03315	COG1846	Transcriptional regulator
M5E03_03320	COG0456	acetyltransferase
M5E03_03325	COG2808	Putative FMN-binding domain
M5E03_03345	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M5E03_03350	COG0823	Involved in the tonB-independent uptake of proteins
M5E03_03360	COG2132	Multicopper oxidase
M5E03_03365	COG1113	amino acid transport
M5E03_03370	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5E03_03375	COG0714	Associated with various cellular activities
M5E03_03380	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M5E03_03385	COG1305	Transglutaminase-like
M5E03_03390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E03_03390	COG0519	Catalyzes the synthesis of GMP from XMP
M5E03_03395	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5E03_03405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E03_03410	COG2207	Transcriptional regulator
M5E03_03435	COG1404	Belongs to the peptidase S8 family
M5E03_03455	COG1595	DNA-templated transcription, initiation
M5E03_03465	COG2814	Major facilitator Superfamily
M5E03_03470	COG0583	DNA-binding transcription factor activity
M5E03_03475	COG2252	PERMEase
M5E03_03490	COG3064	Membrane
M5E03_03495	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M5E03_03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5E03_03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5E03_03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5E03_03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5E03_03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E03_03530	COG0047	phosphoribosylformylglycinamidine synthase activity
M5E03_03535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E03_03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5E03_03545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M5E03_03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5E03_03555	COG0138	bifunctional purine biosynthesis protein purh
M5E03_03560	COG0151	Belongs to the GarS family
M5E03_03580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E03_03585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E03_03590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E03_03595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E03_03605	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5E03_03610	COG4496	protein, YerC YecD
M5E03_03615	COG0069	glutamate synthase activity
M5E03_03630	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M5E03_03635	COG0210	DNA helicase
M5E03_03640	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5E03_03645	COG4851	CamS sex pheromone cAM373 precursor
M5E03_03650	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E03_03655	COG1285	pathogenesis
M5E03_03660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E03_03665	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E03_03670	COG0154	amidase activity
M5E03_03675	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E03_03680	COG1309	transcriptional regulator
M5E03_03685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E03_03690	COG1957	nucleoside hydrolase
M5E03_03695	COG1597	lipid kinase activity
M5E03_03700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5E03_03730	COG0457	Tetratricopeptide repeat
M5E03_03735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E03_03745	COG1737	Transcriptional regulator
M5E03_03750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_03750	COG1263	PTS System
M5E03_03755	COG1486	melibiose metabolic process
M5E03_03765	COG1959	2 iron, 2 sulfur cluster binding
M5E03_03770	COG0492	ferredoxin-NADP+ reductase activity
M5E03_03785	COG1486	melibiose metabolic process
M5E03_03795	COG2211	Major facilitator Superfamily
M5E03_03825	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5E03_03830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E03_03835	COG1442	glycosyl transferase family 8
M5E03_03840	COG1216	Glycosyl transferase, family 2
M5E03_03845	COG1442	glycosyl transferase family 8
M5E03_03850	COG2223	nitrite transmembrane transporter activity
M5E03_03870	COG0693	protein deglycase activity
M5E03_03885	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E03_03900	COG0531	amino acid
M5E03_03905	COG0457	Tetratricopeptide repeat
M5E03_03905	COG0463	Glycosyl transferase, family 2
M5E03_03910	COG0488	(ABC) transporter
M5E03_03915	COG1469	GTP cyclohydrolase I activity
M5E03_03920	COG0789	Transcriptional regulator
M5E03_03925	COG2814	Major facilitator Superfamily
M5E03_03930	COG0488	(ABC) transporter
M5E03_03935	COG0513	Belongs to the DEAD box helicase family
M5E03_03940	COG2130	NADP-dependent
M5E03_03960	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_03960	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_03965	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M5E03_03975	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_03975	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_03985	COG3290	protein histidine kinase activity
M5E03_03990	COG4565	transcriptional regulatory protein
M5E03_03995	COG3181	Tripartite tricarboxylate transporter family receptor
M5E03_04000	COG2851	Citrate transporter
M5E03_04010	COG3479	Phenolic acid decarboxylase
M5E03_04015	COG1695	Transcriptional regulator
M5E03_04020	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M5E03_04025	COG0477	Major facilitator Superfamily
M5E03_04030	COG0583	DNA-binding transcription factor activity
M5E03_04035	COG1254	Belongs to the acylphosphatase family
M5E03_04040	COG2258	MOSC domain
M5E03_04055	COG0024	Methionine aminopeptidase
M5E03_04060	COG1263	PTS System
M5E03_04060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_04065	COG3739	integral membrane protein
M5E03_04080	COG1368	sulfuric ester hydrolase activity
M5E03_04085	COG0076	glutamate decarboxylase activity
M5E03_04100	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_04100	COG1263	PTS System
M5E03_04105	COG0366	Alpha amylase catalytic
M5E03_04110	COG2188	Transcriptional regulator
M5E03_04120	COG0737	Belongs to the 5'-nucleotidase family
M5E03_04125	COG0693	protein deglycase activity
M5E03_04130	COG4840	Belongs to the UPF0435 family
M5E03_04135	COG1115	amino acid carrier protein
M5E03_04140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E03_04145	COG4980	gas vesicle protein
M5E03_04150	COG1295	ribonuclease BN
M5E03_04165	COG0477	Major facilitator Superfamily
M5E03_04175	COG0387	Pfam Sodium calcium exchanger
M5E03_04185	COG0217	transcriptional regulatory protein
M5E03_04190	COG0668	transmembrane transport
M5E03_04195	COG0535	radical SAM domain protein
M5E03_04205	COG0726	polysaccharide deacetylase
M5E03_04210	COG0598	Magnesium transport protein CorA
M5E03_04220	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M5E03_04225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5E03_04240	COG0583	DNA-binding transcription factor activity
M5E03_04245	COG1942	4-Oxalocrotonate Tautomerase
M5E03_04250	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E03_04255	COG0789	Transcriptional regulator
M5E03_04260	COG2814	Major facilitator Superfamily
M5E03_04315	COG2076	Multidrug Resistance protein
M5E03_04320	COG2076	Multidrug Resistance protein
M5E03_04325	COG1309	transcriptional regulator
M5E03_04335	COG4637	Psort location Cytoplasmic, score
M5E03_04340	COG2755	lipolytic protein G-D-S-L family
M5E03_04345	COG0492	ferredoxin-NADP+ reductase activity
M5E03_04350	COG1742	UPF0060 membrane protein
M5E03_04355	COG1595	DNA-templated transcription, initiation
M5E03_04375	COG2318	DinB family
M5E03_04385	COG1846	Transcriptional regulator
M5E03_04390	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M5E03_04390	COG0392	lysyltransferase activity
M5E03_04410	COG0778	Nitroreductase
M5E03_04425	COG1090	epimerase
M5E03_04430	COG2137	regulation of response to DNA damage stimulus
M5E03_04455	COG0463	Glycosyl transferase, family 2
M5E03_04460	COG4485	Bacterial membrane protein, YfhO
M5E03_04465	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M5E03_04480	COG2140	Oxalate decarboxylase
M5E03_04490	COG1191	sigma factor activity
M5E03_04535	COG1988	membrane-bound metal-dependent
M5E03_04540	COG1194	a g-specific adenine glycosylase
M5E03_04550	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_04565	COG3557	Belongs to the UPF0374 family
M5E03_04570	COG1132	(ABC) transporter
M5E03_04575	COG0444	Belongs to the ABC transporter superfamily
M5E03_04580	COG4608	Belongs to the ABC transporter superfamily
M5E03_04585	COG0747	negative chemotaxis
M5E03_04590	COG0601	transmembrane transport
M5E03_04595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_04600	COG4129	membrane
M5E03_04605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E03_04610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E03_04615	COG0735	belongs to the Fur family
M5E03_04760	COG1368	sulfuric ester hydrolase activity
M5E03_04765	COG0681	Belongs to the peptidase S26 family
M5E03_04770	COG2873	o-acetylhomoserine
M5E03_04780	COG1116	anion transmembrane transporter activity
M5E03_04785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E03_04790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E03_04805	COG1131	(ABC) transporter
M5E03_04835	COG3382	B3 4 domain protein
M5E03_04840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5E03_04850	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5E03_04860	COG2766	serine protein kinase
M5E03_04865	COG2718	Belongs to the UPF0229 family
M5E03_04870	COG1566	PFAM secretion protein HlyD family protein
M5E03_04875	COG2814	Major facilitator Superfamily
M5E03_04880	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5E03_04890	COG1278	Cold shock
M5E03_04895	COG3706	GGDEF domain
M5E03_04920	COG5577	PFAM Coat F domain
M5E03_04925	COG5002	protein histidine kinase activity
M5E03_04930	COG0737	Belongs to the 5'-nucleotidase family
M5E03_04930	COG4085	toxin activity
M5E03_04930	COG1525	nuclease
M5E03_04935	COG3764	Sortase (surface protein transpeptidase)
M5E03_04940	COG0564	pseudouridine synthase activity
M5E03_04950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5E03_04955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E03_04955	COG3153	acetyltransferase
M5E03_04970	COG3835	regulator
M5E03_04975	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E03_04980	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M5E03_04985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5E03_04990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5E03_04995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5E03_05000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E03_05005	COG4585	Histidine kinase
M5E03_05005	COG2203	Gaf domain
M5E03_05010	COG2197	response regulator
M5E03_05025	COG0753	catalase activity
M5E03_05030	COG1959	2 iron, 2 sulfur cluster binding
M5E03_05035	COG1017	nitric oxide dioxygenase activity
M5E03_05035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E03_05040	COG2719	SpoVR family
M5E03_05045	COG2721	sulfolactate sulfo-lyase activity
M5E03_05050	COG2186	Transcriptional regulator
M5E03_05055	COG4948	Mandelate Racemase Muconate Lactonizing
M5E03_05060	COG2271	Major facilitator Superfamily
M5E03_05065	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_05070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E03_05075	COG1785	Belongs to the alkaline phosphatase family
M5E03_05080	COG0791	NLP P60 protein
M5E03_05080	COG1388	LysM domain
M5E03_05085	COG0531	amino acid
M5E03_05100	COG1595	DNA-templated transcription, initiation
M5E03_05105	COG0204	Acyl-transferase
M5E03_05110	COG1253	flavin adenine dinucleotide binding
M5E03_05115	COG0789	Transcriptional regulator
M5E03_05120	COG1253	flavin adenine dinucleotide binding
M5E03_05130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E03_05135	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E03_05140	COG0584	glycerophosphoryl diester phosphodiesterase
M5E03_05150	COG0668	transmembrane transport
M5E03_05155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5E03_05160	COG0726	polysaccharide deacetylase
M5E03_05165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_05170	COG0589	response to stress
M5E03_05175	COG1132	(ABC) transporter
M5E03_05180	COG1132	(ABC) transporter
M5E03_05185	COG0702	epimerase
M5E03_05195	COG3842	ATPase activity
M5E03_05200	COG2508	Transcriptional regulator
M5E03_05210	COG0189	ligase activity
M5E03_05215	COG0189	ligase activity
M5E03_05220	COG4399	Belongs to the UPF0754 family
M5E03_05225	COG3679	Belongs to the UPF0342 family
M5E03_05230	COG0561	phosphatase activity
M5E03_05235	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E03_05245	COG0475	glutathione-regulated potassium exporter activity
M5E03_05250	COG0490	domain, Protein
M5E03_05260	COG1024	Enoyl-CoA hydratase
M5E03_05270	COG0420	3'-5' exonuclease activity
M5E03_05275	COG4717	serine-type aminopeptidase activity
M5E03_05280	COG3481	metal-dependent phosphohydrolase, HD sub domain
M5E03_05290	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E03_05320	COG1846	Transcriptional regulator
M5E03_05325	COG4980	gas vesicle protein
M5E03_05340	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5E03_05345	COG0537	adenosine 5'-monophosphoramidase activity
M5E03_05350	COG1131	(ABC) transporter
M5E03_05355	COG4473	ABC transporter
M5E03_05365	COG1473	amidohydrolase
M5E03_05375	COG2329	Antibiotic biosynthesis monooxygenase
M5E03_05380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_05385	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E03_05390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5E03_05395	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M5E03_05400	COG1309	transcriptional regulator
M5E03_05405	COG1511	domain protein
M5E03_05410	COG1363	Peptidase, m42
M5E03_05415	COG1301	dicarboxylic acid transport
M5E03_05425	COG1234	tRNA 3'-trailer cleavage
M5E03_05430	COG0095	Lipoate-protein ligase
M5E03_05435	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_05445	COG0501	Belongs to the peptidase M48B family
M5E03_05450	COG1404	Belongs to the peptidase S8 family
M5E03_05455	COG0406	alpha-ribazole phosphatase activity
M5E03_05460	COG0840	transmembrane signaling receptor activity
M5E03_05465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5E03_05465	COG0723	plastoquinol--plastocyanin reductase activity
M5E03_05470	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_05480	COG4903	ComK protein
M5E03_05490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_05495	COG2814	Major facilitator Superfamily
M5E03_05500	COG2732	(Barnase) inhibitor
M5E03_05505	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_05510	COG4605	iron ion homeostasis
M5E03_05515	COG4604	ABC transporter, ATP-binding protein
M5E03_05520	COG4607	ABC-type enterochelin transport system periplasmic component
M5E03_05525	COG1316	TRANSCRIPTIONal
M5E03_05535	COG0398	Pfam SNARE associated Golgi protein
M5E03_05540	COG0681	Belongs to the peptidase S26 family
M5E03_05545	COG3180	Ammonia monooxygenase
M5E03_05555	COG0501	Belongs to the peptidase M48B family
M5E03_05560	COG2259	Doxx family
M5E03_05565	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M5E03_05570	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M5E03_05575	COG1074	ATP-dependent DNA helicase activity
M5E03_05580	COG0420	3'-5' exonuclease activity
M5E03_05585	COG0419	ATPase involved in DNA repair
M5E03_05590	COG1403	HNH endonuclease
M5E03_05630	COG5337	Spore coat protein CotH
M5E03_05635	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5E03_05650	COG0367	asparagine synthase
M5E03_05665	COG1562	ergosterol biosynthetic process
M5E03_05670	COG0534	Mate efflux family protein
M5E03_05675	COG1917	Cupin 2, conserved barrel domain protein
M5E03_05675	COG2207	Transcriptional regulator
M5E03_05700	COG0076	glutamate decarboxylase activity
M5E03_05730	COG0646	methionine synthase
M5E03_05730	COG1410	methionine synthase
M5E03_05735	COG0646	methionine synthase
M5E03_05735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5E03_05740	COG1666	GTP binding
M5E03_05745	COG2996	Protein conserved in bacteria
M5E03_05750	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E03_05755	COG0840	transmembrane signaling receptor activity
M5E03_05760	COG1307	EDD domain protein, DegV family
M5E03_05765	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_05785	COG0561	phosphatase activity
M5E03_05790	COG1073	alpha beta
M5E03_05795	COG2151	metal-sulfur cluster biosynthetic enzyme
M5E03_05800	COG0277	FAD linked oxidase domain protein
M5E03_05805	COG2271	Major facilitator Superfamily
M5E03_05810	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M5E03_05815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M5E03_05820	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E03_05825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E03_05830	COG0505	Belongs to the CarA family
M5E03_05835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E03_05840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5E03_05850	COG2814	Major facilitator Superfamily
M5E03_05860	COG2267	carboxylic ester hydrolase activity
M5E03_05870	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E03_05885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5E03_05890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E03_05895	COG5504	Zn-dependent protease
M5E03_05900	COG0444	Belongs to the ABC transporter superfamily
M5E03_05905	COG4608	Belongs to the ABC transporter superfamily
M5E03_05915	COG0601	transmembrane transport
M5E03_05920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_05930	COG0180	Tryptophanyl-tRNA synthetase
M5E03_05935	COG4166	transmembrane transport
M5E03_05940	COG0601	transmembrane transport
M5E03_05945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_05950	COG0444	Belongs to the ABC transporter superfamily
M5E03_05955	COG4608	Belongs to the ABC transporter superfamily
M5E03_05965	COG0456	acetyltransferase
M5E03_05970	COG1393	Belongs to the ArsC family
M5E03_05975	COG0861	Integral membrane protein TerC family
M5E03_05980	COG4862	establishment of competence for transformation
M5E03_05985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_05995	COG1164	Oligoendopeptidase f
M5E03_06005	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5E03_06010	COG2346	COG2346, Truncated hemoglobins
M5E03_06015	COG0741	lytic transglycosylase activity
M5E03_06020	COG4116	CYTH
M5E03_06030	COG2357	RelA SpoT domain protein
M5E03_06035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E03_06040	COG0564	pseudouridine synthase activity
M5E03_06045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5E03_06050	COG0475	glutathione-regulated potassium exporter activity
M5E03_06050	COG0569	domain protein
M5E03_06055	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E03_06060	COG0352	thiamine-phosphate diphosphorylase activity
M5E03_06070	COG2104	thiamine diphosphate biosynthetic process
M5E03_06075	COG2022	thiamine diphosphate biosynthetic process
M5E03_06080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E03_06085	COG0351	phosphomethylpyrimidine kinase
M5E03_06090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5E03_06145	COG0210	DNA helicase
M5E03_06160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5E03_06165	COG2382	esterase
M5E03_06170	COG0626	cystathionine gamma-synthase activity
M5E03_06175	COG0626	cystathionine gamma-synthase activity
M5E03_06185	COG1280	lysine exporter protein (LysE YggA)
M5E03_06190	COG0825	malonyl-CoA metabolic process
M5E03_06210	COG0457	Tetratricopeptide repeat
M5E03_06235	COG3173	Aminoglycoside phosphotransferase
M5E03_06240	COG0583	DNA-binding transcription factor activity
M5E03_06260	COG0583	DNA-binding transcription factor activity
M5E03_06265	COG2807	transmembrane transport
M5E03_06275	COG0457	Tetratricopeptide repeat
M5E03_06295	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E03_06305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_06310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_06315	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_06335	COG4195	phage-related replication protein
M5E03_06340	COG2856	Zn peptidase
M5E03_06345	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E03_06345	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_06360	COG0306	phosphate transporter
M5E03_06365	COG1392	Phosphate transport regulator
M5E03_06375	COG0405	Gamma-glutamyltransferase
M5E03_06380	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E03_06390	COG4208	sulfate ABC transporter
M5E03_06395	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M5E03_06405	COG3775	system Galactitol-specific IIC component
M5E03_06425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_06430	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_06430	COG0022	dehydrogenase e1 component
M5E03_06435	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_06440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_06445	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_06450	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_06455	COG2390	Transcriptional regulator
M5E03_06465	COG0531	amino acid
M5E03_06470	COG0346	lactoylglutathione lyase activity
M5E03_06475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_06480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E03_06485	COG2362	D-Aminopeptidase
M5E03_06490	COG0601	transmembrane transport
M5E03_06495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_06500	COG0444	Belongs to the ABC transporter superfamily
M5E03_06505	COG4166	transmembrane transport
M5E03_06510	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E03_06515	COG4948	Mandelate Racemase Muconate Lactonizing
M5E03_06520	COG0791	NLP P60 protein
M5E03_06525	COG4608	Belongs to the ABC transporter superfamily
M5E03_06530	COG1834	amidinotransferase
M5E03_06535	COG1607	acyl-coa hydrolase
M5E03_06540	COG1695	Transcriptional regulator
M5E03_06555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_06570	COG2076	Multidrug Resistance protein
M5E03_06575	COG2076	Multidrug Resistance protein
M5E03_06585	COG0788	formyltetrahydrofolate deformylase activity
M5E03_06590	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5E03_06595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5E03_06600	COG0457	Tetratricopeptide repeat
M5E03_06610	COG1764	response to oxidative stress
M5E03_06615	COG1846	Transcriptional regulator
M5E03_06620	COG1764	response to oxidative stress
M5E03_06625	COG0590	tRNA wobble adenosine to inosine editing
M5E03_06630	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E03_06635	COG1404	Belongs to the peptidase S8 family
M5E03_06640	COG0745	RESPONSE REGULATOR receiver
M5E03_06645	COG3850	Histidine kinase
M5E03_06645	COG5002	protein histidine kinase activity
M5E03_06650	COG3212	peptidase
M5E03_06655	COG3212	peptidase
M5E03_06665	COG2239	Acts as a magnesium transporter
M5E03_06675	COG0789	Transcriptional regulator
M5E03_06690	COG1846	Transcriptional regulator
M5E03_06695	COG3300	MHYT domain
M5E03_06695	COG5001	Diguanylate cyclase
M5E03_06700	COG0586	Pfam SNARE associated Golgi protein
M5E03_06710	COG1191	sigma factor activity
M5E03_06730	COG0501	Belongs to the peptidase M48B family
M5E03_06735	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5E03_06740	COG2323	membrane
M5E03_06755	COG3594	Acyltransferase
M5E03_06760	COG5002	protein histidine kinase activity
M5E03_06765	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5E03_06775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M5E03_06780	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M5E03_06785	COG0436	Aminotransferase
M5E03_06790	COG1850	ribulose-bisphosphate carboxylase activity
M5E03_06795	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M5E03_06800	COG0235	Class ii aldolase
M5E03_06805	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M5E03_06815	COG3852	Histidine kinase
M5E03_06820	COG1846	Transcriptional regulator
M5E03_06825	COG1360	Flagellar Motor Protein
M5E03_06830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5E03_06835	COG0542	response to heat
M5E03_06840	COG3949	Membrane
M5E03_06845	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5E03_06850	COG0720	synthase
M5E03_06855	COG0602	queuosine metabolic process
M5E03_06860	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5E03_06865	COG1733	regulation of RNA biosynthetic process
M5E03_06870	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_06885	COG4873	Protein conserved in bacteria
M5E03_06895	COG3773	Cell wall hydrolase
M5E03_06900	COG2244	polysaccharide biosynthetic process
M5E03_06905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_06910	COG2217	Heavy metal translocating P-type atpase
M5E03_06915	COG0006	proline dipeptidase activity
M5E03_06925	COG1609	Transcriptional regulator
M5E03_06930	COG3711	transcriptional antiterminator
M5E03_06935	COG1263	PTS System
M5E03_06935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_06935	COG2190	(PTS) system
M5E03_06940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_06945	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5E03_06955	COG1533	DNA photolyase activity
M5E03_06960	COG0840	transmembrane signaling receptor activity
M5E03_06970	COG2084	Dehydrogenase
M5E03_06975	COG2340	Cysteine-rich secretory protein family
M5E03_06980	COG0768	penicillin binding
M5E03_06985	COG4191	Histidine kinase
M5E03_06990	COG0436	Aminotransferase
M5E03_06995	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5E03_07005	COG1714	RDD family
M5E03_07015	COG0835	chemotaxis
M5E03_07015	COG0784	Response regulator, receiver
M5E03_07030	COG1917	Cupin 2, conserved barrel domain protein
M5E03_07030	COG2207	Transcriptional regulator
M5E03_07035	COG0697	spore germination
M5E03_07045	COG2814	Major facilitator Superfamily
M5E03_07050	COG1376	ErfK ybiS ycfS ynhG family protein
M5E03_07055	COG1408	metallophosphoesterase
M5E03_07060	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_07065	COG2200	EAL domain
M5E03_07070	COG3546	catalase activity
M5E03_07075	COG4703	Protein of unknown function (DUF1797)
M5E03_07080	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M5E03_07090	COG0517	IMP dehydrogenase activity
M5E03_07095	COG0583	DNA-binding transcription factor activity
M5E03_07100	COG0716	FMN binding
M5E03_07110	COG0716	FMN binding
M5E03_07115	COG2171	N-acyltransferase activity
M5E03_07120	COG1473	amidohydrolase
M5E03_07130	COG0668	transmembrane transport
M5E03_07135	COG0450	alkyl hydroperoxide reductase
M5E03_07140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_07155	COG0746	molybdenum cofactor guanylyltransferase activity
M5E03_07160	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E03_07165	COG0303	'Molybdopterin
M5E03_07170	COG1763	Mo-molybdopterin cofactor biosynthetic process
M5E03_07175	COG0314	molybdopterin synthase activity
M5E03_07180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M5E03_07195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E03_07200	COG1136	(ABC) transporter
M5E03_07205	COG0577	efflux transmembrane transporter activity
M5E03_07210	COG1349	DNA-binding transcription factor activity
M5E03_07215	COG1105	Belongs to the carbohydrate kinase PfkB family
M5E03_07220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_07220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_07220	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_07235	COG0488	(ABC) transporter
M5E03_07240	COG2309	aminopeptidase activity
M5E03_07250	COG1077	Cell shape determining protein MreB Mrl
M5E03_07255	COG2002	toxin-antitoxin pair type II binding
M5E03_07260	COG3852	Histidine kinase
M5E03_07265	COG2105	PFAM AIG2 family protein
M5E03_07265	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M5E03_07270	COG0569	domain protein
M5E03_07275	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5E03_07280	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E03_07285	COG5503	Protein of unknown function (DUF1447)
M5E03_07290	COG0561	phosphatase activity
M5E03_07295	COG0242	peptide deformylase activity
M5E03_07310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_07315	COG0022	dehydrogenase e1 component
M5E03_07320	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_07325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_07330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_07340	COG1982	Orn Lys Arg decarboxylase major
M5E03_07345	COG4476	Belongs to the UPF0223 family
M5E03_07350	COG4493	Belongs to the UPF0637 family
M5E03_07360	COG0483	inositol monophosphate 1-phosphatase activity
M5E03_07375	COG1595	DNA-templated transcription, initiation
M5E03_07395	COG1217	gtp-binding protein TYPA
M5E03_07405	COG4896	Protein conserved in bacteria
M5E03_07415	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M5E03_07420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M5E03_07425	COG2066	Belongs to the glutaminase family
M5E03_07430	COG4838	Belongs to the UPF0358 family
M5E03_07435	COG0772	Belongs to the SEDS family
M5E03_07440	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M5E03_07445	COG0415	Belongs to the DNA photolyase family
M5E03_07450	COG1612	heme a metabolic process
M5E03_07455	COG0109	protoheme IX farnesyltransferase activity
M5E03_07460	COG2010	Cytochrome c
M5E03_07460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E03_07465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E03_07470	COG1845	cytochrome c oxidase, subunit III
M5E03_07475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E03_07480	COG3336	cytochrome c oxidase
M5E03_07490	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M5E03_07495	COG2340	Cysteine-rich secretory protein family
M5E03_07515	COG3679	Belongs to the UPF0342 family
M5E03_07520	COG4471	UPF0298 protein
M5E03_07525	COG0742	ribosomal rna small subunit methyltransferase
M5E03_07530	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M5E03_07535	COG3314	Sporulation integral membrane protein YlbJ
M5E03_07540	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E03_07545	COG3480	Lon protease (S16) C-terminal proteolytic domain
M5E03_07555	COG1399	metal-binding, possibly nucleic acid-binding protein
M5E03_07560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M5E03_07570	COG0454	-acetyltransferase
M5E03_07575	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5E03_07580	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M5E03_07585	COG2001	Belongs to the MraZ family
M5E03_07590	COG0275	rRNA processing
M5E03_07595	COG4839	cell division protein FtsL
M5E03_07600	COG0768	penicillin binding
M5E03_07605	COG0768	penicillin binding
M5E03_07615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5E03_07620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5E03_07625	COG0772	Belongs to the SEDS family
M5E03_07630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5E03_07635	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M5E03_07640	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5E03_07645	COG3879	Bacterial protein of unknown function (DUF881)
M5E03_07650	COG3879	Bacterial protein of unknown function (DUF881)
M5E03_07655	COG3856	small basic protein
M5E03_07660	COG0849	cell division
M5E03_07665	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5E03_07670	COG1404	Belongs to the peptidase S8 family
M5E03_07670	COG4412	M6 family metalloprotease domain protein
M5E03_07680	COG1191	sigma factor activity
M5E03_07685	COG1191	sigma factor activity
M5E03_07690	COG2390	Transcriptional regulator
M5E03_07705	COG3730	PTS system glucitol sorbitol-specific
M5E03_07710	COG3732	PTS system glucitol sorbitol-specific
M5E03_07720	COG1119	ATPase activity
M5E03_07725	COG1873	PFAM PRC-barrel domain
M5E03_07730	COG1496	oxidoreductase activity
M5E03_07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M5E03_07740	COG1799	cell septum assembly
M5E03_07745	COG0762	integral membrane protein
M5E03_07750	COG2302	S4 RNA-binding domain
M5E03_07755	COG3599	regulation of cell shape
M5E03_07760	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5E03_07765	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E03_07770	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M5E03_07775	COG0564	pseudouridine synthase activity
M5E03_07780	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M5E03_07785	COG2233	PERMEase
M5E03_07790	COG0540	Belongs to the ATCase OTCase family
M5E03_07795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M5E03_07800	COG0505	Belongs to the CarA family
M5E03_07805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E03_07810	COG0543	2 iron, 2 sulfur cluster binding
M5E03_07815	COG0167	dihydroorotate dehydrogenase activity
M5E03_07820	COG0284	orotidine-5'-phosphate decarboxylase activity
M5E03_07825	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5E03_07835	COG0175	sulfate reduction
M5E03_07840	COG0306	phosphate transporter
M5E03_07845	COG2046	Belongs to the sulfate adenylyltransferase family
M5E03_07850	COG0529	Catalyzes the synthesis of activated sulfate
M5E03_07855	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5E03_07860	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M5E03_07865	COG1648	precorrin-2 dehydrogenase activity
M5E03_07875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M5E03_07880	COG1561	YicC-like family, N-terminal region
M5E03_07885	COG2052	Domain of unknown function (DUF370)
M5E03_07890	COG0194	GDP metabolic process
M5E03_07895	COG1758	RNA polymerase activity
M5E03_07900	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E03_07905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5E03_07910	COG0242	peptide deformylase activity
M5E03_07915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M5E03_07920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5E03_07920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E03_07925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M5E03_07930	COG0631	protein serine/threonine phosphatase activity
M5E03_07935	COG2815	serine threonine protein kinase
M5E03_07935	COG0515	serine threonine protein kinase
M5E03_07940	COG1162	GTPase activity
M5E03_07945	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E03_07950	COG1564	THIamine pyrophosphokinase
M5E03_07960	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5E03_07965	COG1302	Protein conserved in bacteria
M5E03_07970	COG1461	Dihydroxyacetone kinase
M5E03_07975	COG1760	l-serine dehydratase
M5E03_07980	COG1760	l-serine dehydratase
M5E03_07985	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5E03_07990	COG1349	DNA-binding transcription factor activity
M5E03_07995	COG0416	fatty acid biosynthetic process
M5E03_08000	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M5E03_08005	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_08010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E03_08020	COG1196	nuclear chromosome segregation
M5E03_08025	COG0552	protein localization to endoplasmic reticulum
M5E03_08030	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M5E03_08035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5E03_08040	COG0228	four-way junction DNA binding
M5E03_08045	COG1837	Belongs to the UPF0109 family
M5E03_08055	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5E03_08060	COG0336	Belongs to the RNA methyltransferase TrmD family
M5E03_08065	COG0335	large ribosomal subunit rRNA binding
M5E03_08070	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5E03_08075	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E03_08085	COG2257	FlhB HrpN YscU SpaS Family
M5E03_08090	COG0045	succinate-CoA ligase (ADP-forming) activity
M5E03_08095	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M5E03_08100	COG0758	DNA mediated transformation
M5E03_08105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5E03_08110	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M5E03_08115	COG4974	Belongs to the 'phage' integrase family
M5E03_08120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M5E03_08125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M5E03_08130	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5E03_08135	COG1815	bacterial-type flagellum-dependent cell motility
M5E03_08140	COG1558	bacterial-type flagellum-dependent cell motility
M5E03_08145	COG1677	Flagellar hook-basal body complex protein FliE
M5E03_08150	COG1766	The M ring may be actively involved in energy transduction
M5E03_08155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E03_08160	COG1317	bacterial-type flagellum organization
M5E03_08165	COG1157	protein secretion by the type III secretion system
M5E03_08170	COG2882	bacterial-type flagellum organization
M5E03_08175	COG3334	PFAM MgtE intracellular
M5E03_08180	COG3144	bacterial-type flagellum assembly
M5E03_08185	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M5E03_08190	COG4786	Flagellar basal body rod
M5E03_08195	COG1582	Flagellar protein (FlbD)
M5E03_08200	COG1580	Controls the rotational direction of flagella during chemotaxis
M5E03_08205	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E03_08210	COG1776	CheC inhibitor of MCP methylation
M5E03_08210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E03_08215	COG2201	protein-glutamate methylesterase activity
M5E03_08220	COG3190	flagellar
M5E03_08225	COG1338	Plays a role in the flagellum-specific transport system
M5E03_08230	COG1987	bacterial-type flagellum assembly
M5E03_08235	COG1684	flagellar biosynthetic protein fliR
M5E03_08240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5E03_08245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5E03_08250	COG1419	protein localization to endoplasmic reticulum
M5E03_08255	COG0455	bacterial-type flagellum organization
M5E03_08260	COG2201	protein-glutamate methylesterase activity
M5E03_08265	COG0643	Histidine kinase
M5E03_08265	COG2198	Histidine kinase
M5E03_08270	COG0835	chemotaxis
M5E03_08275	COG1776	CheC inhibitor of MCP methylation
M5E03_08285	COG1191	sigma factor activity
M5E03_08300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M5E03_08305	COG0528	UMP kinase activity
M5E03_08310	COG0233	cytoplasmic translational termination
M5E03_08315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5E03_08320	COG4589	Belongs to the CDS family
M5E03_08325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M5E03_08330	COG0750	zinc metalloprotease
M5E03_08335	COG0442	prolyl-tRNA aminoacylation
M5E03_08340	COG2176	DNA-directed DNA polymerase activity
M5E03_08355	COG3693	PFAM glycoside hydrolase, family 10
M5E03_08375	COG1131	(ABC) transporter
M5E03_08425	COG0779	Required for maturation of 30S ribosomal subunits
M5E03_08430	COG0195	Participates in both transcription termination and antitermination
M5E03_08435	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M5E03_08440	COG1358	cellular component organization or biogenesis
M5E03_08445	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5E03_08450	COG1550	Protein conserved in bacteria
M5E03_08455	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5E03_08460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5E03_08465	COG0196	riboflavin kinase activity
M5E03_08470	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5E03_08475	COG1185	polyribonucleotide nucleotidyltransferase activity
M5E03_08480	COG0726	polysaccharide deacetylase
M5E03_08485	COG0612	Peptidase, M16
M5E03_08495	COG1873	PFAM PRC-barrel domain
M5E03_08500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E03_08505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E03_08510	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5E03_08515	COG0527	aspartate kinase activity
M5E03_08525	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E03_08530	COG0740	serine-type endopeptidase activity
M5E03_08540	COG1674	ftsk spoiiie
M5E03_08540	COG4980	gas vesicle protein
M5E03_08545	COG2188	Transcriptional regulator
M5E03_08550	COG2814	Major facilitator Superfamily
M5E03_08555	COG1033	growth of symbiont in host cell
M5E03_08555	COG2409	Drug exporters of the RND superfamily
M5E03_08560	COG0612	Peptidase, M16
M5E03_08565	COG0612	Peptidase, M16
M5E03_08575	COG1033	growth of symbiont in host cell
M5E03_08575	COG2409	Drug exporters of the RND superfamily
M5E03_08580	COG0300	oxidoreductase activity
M5E03_08595	COG1426	Protein conserved in bacteria
M5E03_08600	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E03_08605	COG1058	Belongs to the CinA family
M5E03_08605	COG1546	Belongs to the CinA family
M5E03_08610	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5E03_08615	COG1418	mRNA catabolic process
M5E03_08620	COG1692	metallophosphoesterase
M5E03_08625	COG2359	stage V sporulation protein S
M5E03_08630	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E03_08635	COG1063	alcohol dehydrogenase
M5E03_08640	COG0156	8-amino-7-oxononanoate synthase activity
M5E03_08645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E03_08650	COG4550	Control of competence regulator ComK, YlbF/YmcA
M5E03_08660	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M5E03_08665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5E03_08680	COG1329	Transcriptional regulator
M5E03_08685	COG4195	phage-related replication protein
M5E03_08690	COG0457	Tetratricopeptide repeat
M5E03_08695	COG1404	Belongs to the peptidase S8 family
M5E03_08700	COG4195	phage-related replication protein
M5E03_08705	COG1764	response to oxidative stress
M5E03_08710	COG2076	Multidrug Resistance protein
M5E03_08740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5E03_08745	COG1923	regulation of RNA biosynthetic process
M5E03_08760	COG1780	Probably involved in ribonucleotide reductase function
M5E03_08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E03_08770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E03_08775	COG4112	unkown
M5E03_08785	COG0464	growth
M5E03_08790	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5E03_08795	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M5E03_08800	COG0789	Transcriptional regulator
M5E03_08805	COG0174	glutamine synthetase
M5E03_08830	COG0457	Tetratricopeptide repeat
M5E03_08835	COG5444	nuclease activity
M5E03_08855	COG5646	InterPro IPR014922
M5E03_08860	COG0457	Tetratricopeptide repeat
M5E03_08865	COG3619	membrane
M5E03_08870	COG1793	dna ligase
M5E03_08870	COG3285	dna ligase
M5E03_08875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M5E03_08880	COG4876	unkown
M5E03_08890	COG1959	2 iron, 2 sulfur cluster binding
M5E03_08895	COG0702	epimerase
M5E03_08900	COG0247	lactate metabolic process
M5E03_08905	COG1139	Iron-sulfur cluster binding protein
M5E03_08910	COG1556	Lactate utilization protein
M5E03_08930	COG2323	membrane
M5E03_08935	COG1309	transcriptional regulator
M5E03_08940	COG2124	cytochrome p450
M5E03_08940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E03_08945	COG3591	Belongs to the peptidase S1B family
M5E03_08950	COG3209	COG3209 Rhs family protein
M5E03_08955	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_08970	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5E03_08975	COG1388	LysM domain
M5E03_08980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M5E03_08985	COG4224	UPF0291 protein
M5E03_08990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5E03_09000	COG3763	UPF0154 protein
M5E03_09010	COG0785	Cytochrome C biogenesis protein
M5E03_09015	COG4846	Membrane protein involved in cytochrome C biogenesis
M5E03_09025	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E03_09040	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5E03_09045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_09065	COG0824	Thioesterase
M5E03_09075	COG4841	protein insertion into membrane
M5E03_09080	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M5E03_09085	COG1832	CoA-binding protein
M5E03_09090	COG0187	DNA topoisomerase II activity
M5E03_09095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5E03_09105	COG0738	Major facilitator superfamily
M5E03_09110	COG0110	maltose O-acetyltransferase activity
M5E03_09115	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E03_09120	COG1733	regulation of RNA biosynthetic process
M5E03_09130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_09135	COG0251	oxidation-reduction process
M5E03_09160	COG0583	DNA-binding transcription factor activity
M5E03_09165	COG2851	Citrate transporter
M5E03_09170	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E03_09175	COG0183	Belongs to the thiolase family
M5E03_09180	COG1024	Enoyl-CoA hydratase
M5E03_09185	COG1024	Enoyl-CoA hydratase
M5E03_09190	COG1024	Enoyl-CoA hydratase
M5E03_09195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E03_09220	COG0657	acetylesterase activity
M5E03_09230	COG2723	6-phospho-beta-galactosidase activity
M5E03_09235	COG1263	PTS System
M5E03_09235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_09235	COG2190	(PTS) system
M5E03_09250	COG2205	protein histidine kinase activity
M5E03_09255	COG0745	RESPONSE REGULATOR receiver
M5E03_09265	COG3507	Belongs to the glycosyl hydrolase 43 family
M5E03_09270	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_09275	COG1486	melibiose metabolic process
M5E03_09280	COG0395	ABC-type sugar transport system, permease component
M5E03_09285	COG1175	transmembrane transport
M5E03_09290	COG1653	transport
M5E03_09295	COG1609	Transcriptional regulator
M5E03_09300	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E03_09315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_09355	COG5444	nuclease activity
M5E03_09360	COG1846	Transcriptional regulator
M5E03_09365	COG2814	Major facilitator Superfamily
M5E03_09375	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_09375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_09375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_09380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_09380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E03_09380	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_09385	COG1105	Belongs to the carbohydrate kinase PfkB family
M5E03_09395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_09425	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E03_09430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E03_09435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E03_09440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E03_09445	COG1024	Enoyl-CoA hydratase
M5E03_09450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E03_09455	COG0511	ligase activity, forming carbon-carbon bonds
M5E03_09460	COG0439	Biotin carboxylase
M5E03_09465	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_09470	COG1960	acyl-CoA dehydrogenase activity
M5E03_09475	COG1649	PFAM Uncharacterised BCR, COG1649
M5E03_09480	COG2365	Tyrosine phosphatase family
M5E03_09485	COG1349	DNA-binding transcription factor activity
M5E03_09495	COG3835	regulator
M5E03_09500	COG0277	FAD linked oxidase domain protein
M5E03_09505	COG0247	lactate metabolic process
M5E03_09535	COG0166	Belongs to the GPI family
M5E03_09540	COG0586	Pfam SNARE associated Golgi protein
M5E03_09545	COG1587	Uroporphyrinogen-III synthase
M5E03_09555	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_09570	COG0534	Mate efflux family protein
M5E03_09575	COG2027	D-alanyl-D-alanine carboxypeptidase
M5E03_09580	COG4677	pectinesterase activity
M5E03_09585	COG2323	membrane
M5E03_09590	COG2146	nitrite reductase [NAD(P)H] activity
M5E03_09595	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E03_09600	COG0243	molybdopterin cofactor binding
M5E03_09605	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E03_09610	COG2223	nitrite transmembrane transporter activity
M5E03_09615	COG0493	'glutamate synthase
M5E03_09620	COG0067	glutamate synthase
M5E03_09620	COG0069	glutamate synthase activity
M5E03_09620	COG0070	glutamate synthase
M5E03_09625	COG0583	DNA-binding transcription factor activity
M5E03_09640	COG4978	Transcriptional regulator
M5E03_09640	COG0789	Transcriptional regulator
M5E03_09645	COG0454	-acetyltransferase
M5E03_09650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5E03_09655	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5E03_09670	COG0243	molybdopterin cofactor binding
M5E03_09680	COG1070	Carbohydrate kinase
M5E03_09685	COG2115	Belongs to the xylose isomerase family
M5E03_09700	COG2211	Major facilitator Superfamily
M5E03_09705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_09710	COG1994	Peptidase M50
M5E03_09730	COG1309	transcriptional regulator
M5E03_09735	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_09740	COG3708	Transcriptional regulator
M5E03_09745	COG2378	regulation of single-species biofilm formation
M5E03_09755	COG0640	Transcriptional regulator
M5E03_09760	COG0531	amino acid
M5E03_09765	COG0741	lytic transglycosylase activity
M5E03_09770	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M5E03_09775	COG2079	MmgE PrpD family protein
M5E03_09780	COG0372	Belongs to the citrate synthase family
M5E03_09785	COG2322	membrane
M5E03_09795	COG1388	LysM domain
M5E03_09795	COG3584	3D domain protein
M5E03_09800	COG0514	ATP-dependent DNA helicase (RecQ)
M5E03_09810	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E03_09835	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_09840	COG1657	PFAM Prenyltransferase squalene oxidase
M5E03_09845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E03_09850	COG0385	Bile acid
M5E03_09855	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_09860	COG0567	Dehydrogenase, E1 component
M5E03_09865	COG4548	von Willebrand factor, type A
M5E03_09870	COG0714	Associated with various cellular activities
M5E03_09875	COG2032	superoxide dismutase activity
M5E03_09880	COG1388	LysM domain
M5E03_09880	COG0791	NLP P60 protein
M5E03_09885	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5E03_09890	COG0534	Mate efflux family protein
M5E03_09895	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E03_09900	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E03_09910	COG2962	Rard protein
M5E03_09925	COG1733	regulation of RNA biosynthetic process
M5E03_09930	COG0778	Nitroreductase
M5E03_09940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E03_09945	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_09945	COG0793	Belongs to the peptidase S41A family
M5E03_09950	COG2226	methyltransferase
M5E03_09960	COG1876	peptidase activity
M5E03_09965	COG0813	purine-nucleoside phosphorylase activity
M5E03_09975	COG0671	phosphoesterase, PA-phosphatase related
M5E03_09990	COG4479	Belongs to the UPF0346 family
M5E03_10000	COG1509	lysine 2,3-aminomutase activity
M5E03_10005	COG3829	transcription factor binding
M5E03_10010	COG0463	Glycosyl transferase, family 2
M5E03_10025	COG4641	Protein conserved in bacteria
M5E03_10035	COG1086	Polysaccharide biosynthesis protein
M5E03_10040	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E03_10045	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E03_10050	COG1846	Transcriptional regulator
M5E03_10070	COG4698	Protein conserved in bacteria
M5E03_10075	COG2755	lipolytic protein G-D-S-L family
M5E03_10080	COG1999	signal sequence binding
M5E03_10095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M5E03_10100	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M5E03_10105	COG1272	protein, Hemolysin III
M5E03_10110	COG0204	Acyl-transferase
M5E03_10115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5E03_10120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5E03_10125	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E03_10135	COG2521	methyltransferase
M5E03_10135	COG2136	Putative SAM-dependent methyltransferase
M5E03_10145	COG0129	dihydroxy-acid dehydratase activity
M5E03_10150	COG1413	lyase activity
M5E03_10155	COG1418	mRNA catabolic process
M5E03_10160	COG0386	Belongs to the glutathione peroxidase family
M5E03_10165	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M5E03_10170	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M5E03_10175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5E03_10185	COG1278	Cold shock
M5E03_10200	COG0328	RNA-DNA hybrid ribonuclease activity
M5E03_10205	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M5E03_10210	COG0328	RNA-DNA hybrid ribonuclease activity
M5E03_10220	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E03_10230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5E03_10235	COG1755	Isoprenylcysteine carboxyl methyltransferase
M5E03_10240	COG3424	synthase
M5E03_10245	COG0726	polysaccharide deacetylase
M5E03_10250	COG2233	PERMEase
M5E03_10255	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E03_10260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M5E03_10265	COG1199	ATP-dependent helicase activity
M5E03_10275	COG0116	Belongs to the methyltransferase superfamily
M5E03_10285	COG3599	regulation of cell shape
M5E03_10290	COG4474	Belongs to the UPF0398 family
M5E03_10300	COG3359	exonuclease
M5E03_10305	COG1111	helicase
M5E03_10305	COG1205	dead DEAH box helicase
M5E03_10310	COG1902	pentaerythritol trinitrate reductase activity
M5E03_10315	COG2190	(PTS) system
M5E03_10320	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E03_10350	COG3331	DNA recombination
M5E03_10355	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5E03_10355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_10365	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5E03_10370	COG3935	DnaD domain protein
M5E03_10375	COG0017	Asparaginyl-tRNA synthetase
M5E03_10380	COG5353	protein conserved in bacteria
M5E03_10390	COG1199	ATP-dependent helicase activity
M5E03_10390	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E03_10395	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M5E03_10400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M5E03_10405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M5E03_10415	COG0617	tRNA 3'-terminal CCA addition
M5E03_10420	COG0438	transferase activity, transferring glycosyl groups
M5E03_10425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E03_10430	COG1803	Methylglyoxal synthase
M5E03_10435	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5E03_10440	COG1694	Mazg nucleotide pyrophosphohydrolase
M5E03_10445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_10455	COG4347	Protein of unknown function (DUF1405)
M5E03_10460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5E03_10460	COG2010	Cytochrome c
M5E03_10465	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5E03_10470	COG0723	plastoquinol--plastocyanin reductase activity
M5E03_10480	COG5582	Belongs to the UPF0302 family
M5E03_10485	COG0457	Tetratricopeptide repeat
M5E03_10490	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5E03_10495	COG0287	Prephenate dehydrogenase
M5E03_10500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M5E03_10505	COG0159	tryptophan synthase activity
M5E03_10510	COG0133	tryptophan synthase activity
M5E03_10515	COG0135	phosphoribosylanthranilate isomerase activity
M5E03_10520	COG0134	indole-3-glycerol-phosphate synthase activity
M5E03_10535	COG4401	Chorismate mutase type I
M5E03_10540	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M5E03_10545	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M5E03_10550	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M5E03_10555	COG0105	UTP biosynthetic process
M5E03_10560	COG0142	geranyltranstransferase activity
M5E03_10565	COG2226	methyltransferase
M5E03_10570	COG0142	geranyltranstransferase activity
M5E03_10580	COG0302	gtp cyclohydrolase
M5E03_10585	COG0776	regulation of translation
M5E03_10590	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5E03_10605	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M5E03_10610	COG1160	GTP binding
M5E03_10635	COG1304	FMN binding
M5E03_10640	COG0539	negative regulation of cytoplasmic translation
M5E03_10645	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M5E03_10655	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M5E03_10660	COG2959	enzyme of heme biosynthesis
M5E03_10665	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_10665	COG3773	Cell wall hydrolase
M5E03_10670	COG2339	peptidase activity
M5E03_10675	COG0492	ferredoxin-NADP+ reductase activity
M5E03_10680	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E03_10685	COG4862	establishment of competence for transformation
M5E03_10690	COG1408	metallophosphoesterase
M5E03_10700	COG1388	LysM domain
M5E03_10705	COG1266	CAAX protease self-immunity
M5E03_10710	COG0514	ATP-dependent DNA helicase (RecQ)
M5E03_10715	COG4955	Helix-turn-helix domain
M5E03_10720	COG1141	Ferredoxin
M5E03_10725	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M5E03_10730	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5E03_10735	COG1388	LysM domain
M5E03_10735	COG0791	NLP P60 protein
M5E03_10745	COG1595	DNA-templated transcription, initiation
M5E03_10750	COG5002	protein histidine kinase activity
M5E03_10755	COG0745	RESPONSE REGULATOR receiver
M5E03_10760	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5E03_10765	COG1333	cytochrome c biogenesis protein
M5E03_10770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_10775	COG1187	pseudouridine synthase activity
M5E03_10780	COG0700	Nucleoside recognition
M5E03_10785	COG2715	membrane protein required for spore maturation
M5E03_10790	COG1686	Belongs to the peptidase S11 family
M5E03_10800	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M5E03_10805	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M5E03_10815	COG1547	Domain of unknown function (DUF309)
M5E03_10820	COG0456	acetyltransferase
M5E03_10825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M5E03_10835	COG0307	riboflavin synthase, alpha
M5E03_10855	COG2814	Major facilitator Superfamily
M5E03_10860	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5E03_10865	COG4086	secreted protein
M5E03_10870	COG0019	diaminopimelate decarboxylase activity
M5E03_10875	COG0697	spore germination
M5E03_10890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5E03_10910	COG1191	sigma factor activity
M5E03_10915	COG2172	sigma factor antagonist activity
M5E03_10925	COG1686	Belongs to the peptidase S11 family
M5E03_10930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M5E03_10935	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M5E03_10940	COG4974	Belongs to the 'phage' integrase family
M5E03_10950	COG0735	belongs to the Fur family
M5E03_10955	COG1300	Membrane
M5E03_10960	COG1404	Belongs to the peptidase S8 family
M5E03_10970	COG2153	protein acetylation
M5E03_10975	COG1379	DNA repair
M5E03_10980	COG0494	nUDIX hydrolase
M5E03_10985	COG0667	Aldo Keto reductase
M5E03_11000	COG1073	alpha beta
M5E03_11005	COG0457	Tetratricopeptide repeat
M5E03_11015	COG4918	Iron-sulphur cluster biosynthesis
M5E03_11020	COG0456	acetyltransferase
M5E03_11020	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M5E03_11025	COG0456	acetyltransferase
M5E03_11035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E03_11045	COG2211	Major facilitator Superfamily
M5E03_11050	COG1072	(Pantothenic acid kinase))
M5E03_11055	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E03_11060	COG0300	oxidoreductase activity
M5E03_11065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_11070	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E03_11080	COG4187	Peptidase family M20/M25/M40
M5E03_11085	COG1902	pentaerythritol trinitrate reductase activity
M5E03_11090	COG0596	Alpha beta hydrolase
M5E03_11095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E03_11105	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M5E03_11110	COG2188	Transcriptional regulator
M5E03_11115	COG2723	6-phospho-beta-galactosidase activity
M5E03_11120	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_11125	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E03_11130	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_11135	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_11145	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5E03_11150	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E03_11165	COG0706	membrane insertase activity
M5E03_11175	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5E03_11180	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E03_11185	COG0346	lactoylglutathione lyase activity
M5E03_11195	COG1376	ErfK ybiS ycfS ynhG family protein
M5E03_11200	COG4129	membrane
M5E03_11205	COG1126	abc transporter atp-binding protein
M5E03_11210	COG0765	amino acid transport
M5E03_11215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_11225	COG1597	lipid kinase activity
M5E03_11235	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E03_11240	COG0022	dehydrogenase e1 component
M5E03_11245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E03_11250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E03_11255	COG3426	butyrate kinase activity
M5E03_11260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E03_11265	COG0280	phosphate acetyltransferase
M5E03_11270	COG3290	protein histidine kinase activity
M5E03_11270	COG3829	transcription factor binding
M5E03_11280	COG0584	glycerophosphoryl diester phosphodiesterase
M5E03_11285	COG0457	Tetratricopeptide repeat
M5E03_11295	COG0745	RESPONSE REGULATOR receiver
M5E03_11300	COG0750	zinc metalloprotease
M5E03_11305	COG0497	DNA recombination
M5E03_11310	COG1438	arginine binding
M5E03_11315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M5E03_11320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5E03_11325	COG0142	geranyltranstransferase activity
M5E03_11330	COG1722	exodeoxyribonuclease VII activity
M5E03_11335	COG1570	exodeoxyribonuclease VII activity
M5E03_11340	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M5E03_11345	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E03_11350	COG1302	Protein conserved in bacteria
M5E03_11355	COG0439	Biotin carboxylase
M5E03_11360	COG0511	ligase activity, forming carbon-carbon bonds
M5E03_11400	COG3854	ATPases associated with a variety of cellular activities
M5E03_11410	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5E03_11415	COG0006	proline dipeptidase activity
M5E03_11420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M5E03_11430	COG3872	metal-dependent enzyme
M5E03_11440	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E03_11445	COG1321	iron dependent repressor
M5E03_11450	COG0095	Lipoate-protein ligase
M5E03_11455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_11460	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5E03_11465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5E03_11470	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M5E03_11475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5E03_11500	COG0681	Belongs to the peptidase S26 family
M5E03_11530	COG4970	Tfp pilus assembly protein FimT
M5E03_11535	COG4537	Required for transformation and DNA binding
M5E03_11540	COG1459	type II secretion system
M5E03_11545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5E03_11550	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_11560	COG1393	Belongs to the ArsC family
M5E03_11570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_11580	COG0011	TIGRFAM Protein of
M5E03_11585	COG2814	Major facilitator Superfamily
M5E03_11590	COG2866	Carboxypeptidase
M5E03_11595	COG1368	sulfuric ester hydrolase activity
M5E03_11600	COG1940	carbohydrate kinase activity
M5E03_11605	COG4483	Protein conserved in bacteria
M5E03_11610	COG0457	Tetratricopeptide repeat
M5E03_11610	COG0705	Rhomboid family
M5E03_11625	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5E03_11630	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E03_11640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E03_11645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E03_11650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E03_11655	COG0581	inorganic phosphate transmembrane transporter activity
M5E03_11660	COG0573	inorganic phosphate transmembrane transporter activity
M5E03_11665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5E03_11670	COG0768	penicillin binding
M5E03_11675	COG0477	Major facilitator Superfamily
M5E03_11680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E03_11685	COG2839	Protein conserved in bacteria
M5E03_11690	COG5521	maltodextrose utilization protein MalA
M5E03_11695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E03_11700	COG1388	LysM domain
M5E03_11705	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M5E03_11710	COG4709	membrane
M5E03_11715	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M5E03_11720	COG1940	carbohydrate kinase activity
M5E03_11725	COG0735	belongs to the Fur family
M5E03_11730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E03_11735	COG1121	(ABC) transporter
M5E03_11740	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_11755	COG0513	Belongs to the DEAD box helicase family
M5E03_11765	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M5E03_11770	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E03_11775	COG2384	SAM-dependent methyltransferase
M5E03_11780	COG2010	Cytochrome c
M5E03_11785	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5E03_11790	COG0358	DNA primase activity
M5E03_11795	COG1671	Belongs to the UPF0178 family
M5E03_11800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M5E03_11805	COG0517	IMP dehydrogenase activity
M5E03_11810	COG0751	glycine-tRNA ligase activity
M5E03_11815	COG0752	glycyl-tRNA synthetase alpha subunit
M5E03_11820	COG1381	Involved in DNA repair and RecF pathway recombination
M5E03_11830	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5E03_11835	COG0295	cytidine deaminase activity
M5E03_11840	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5E03_11845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5E03_11850	COG1480	7TM receptor with intracellular HD hydrolase
M5E03_11855	COG1702	phosphate starvation-inducible protein PhoH
M5E03_11860	COG0561	phosphatase activity
M5E03_11875	COG4864	UPF0365 protein
M5E03_11880	COG1030	water channel activity
M5E03_11885	COG1610	YqeY-like protein
M5E03_11895	COG1283	sodium-dependent phosphate transmembrane transporter activity
M5E03_11900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E03_11905	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E03_11910	COG2264	protein methyltransferase activity
M5E03_11915	COG0484	heat shock protein binding
M5E03_11920	COG0443	Heat shock 70 kDa protein
M5E03_11925	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M5E03_11930	COG1420	regulation of RNA biosynthetic process
M5E03_11935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E03_11940	COG0481	GTPase activity
M5E03_11950	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_11955	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M5E03_11960	COG0268	Binds directly to 16S ribosomal RNA
M5E03_11965	COG1466	dna polymerase III delta subunit
M5E03_11975	COG0658	competence protein
M5E03_11975	COG2333	competence protein COMEC
M5E03_11980	COG2131	deaminase
M5E03_11985	COG1555	photosystem II stabilization
M5E03_11990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E03_11995	COG2226	methyltransferase
M5E03_12000	COG0799	negative regulation of ribosome biogenesis
M5E03_12005	COG1713	HD superfamily hydrolase involved in NAD metabolism
M5E03_12010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5E03_12015	COG1534	Rna-binding protein
M5E03_12020	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M5E03_12025	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5E03_12030	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M5E03_12045	COG2755	lipolytic protein G-D-S-L family
M5E03_12055	COG0457	Tetratricopeptide repeat
M5E03_12065	COG2318	DinB family
M5E03_12090	COG0726	polysaccharide deacetylase
M5E03_12125	COG1131	(ABC) transporter
M5E03_12145	COG2160	L-arabinose isomerase activity
M5E03_12160	COG1609	Transcriptional regulator
M5E03_12170	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5E03_12175	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M5E03_12180	COG1733	regulation of RNA biosynthetic process
M5E03_12185	COG0657	acetylesterase activity
M5E03_12230	COG1309	transcriptional regulator
M5E03_12235	COG0109	protoheme IX farnesyltransferase activity
M5E03_12240	COG2602	Beta-lactamase
M5E03_12245	COG1960	acyl-CoA dehydrogenase activity
M5E03_12250	COG1126	abc transporter atp-binding protein
M5E03_12255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_12260	COG0765	amino acid transport
M5E03_12270	COG3546	catalase activity
M5E03_12275	COG1063	alcohol dehydrogenase
M5E03_12285	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_12290	COG1132	(ABC) transporter
M5E03_12295	COG0454	-acetyltransferase
M5E03_12300	COG2226	methyltransferase
M5E03_12305	COG1063	alcohol dehydrogenase
M5E03_12310	COG2226	methyltransferase
M5E03_12335	COG0626	cystathionine gamma-synthase activity
M5E03_12340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_12345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5E03_12350	COG2226	methyltransferase
M5E03_12365	COG0768	penicillin binding
M5E03_12370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E03_12380	COG0572	uridine kinase
M5E03_12385	COG0826	peptidase U32
M5E03_12390	COG0826	peptidase U32
M5E03_12395	COG4122	O-methyltransferase activity
M5E03_12400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E03_12405	COG0183	Belongs to the thiolase family
M5E03_12410	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_12415	COG1268	BioY protein
M5E03_12420	COG3906	Belongs to the UPF0473 family
M5E03_12425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5E03_12430	COG4472	Bacterial protein of unknown function (DUF965)
M5E03_12435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5E03_12440	COG0628	permease
M5E03_12445	COG1126	abc transporter atp-binding protein
M5E03_12450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_12455	COG0765	amino acid transport
M5E03_12460	COG0765	amino acid transport
M5E03_12475	COG3881	PFAM PRC-barrel domain
M5E03_12480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E03_12485	COG0457	Tetratricopeptide repeat
M5E03_12490	COG0482	sulfurtransferase activity
M5E03_12495	COG1104	cysteine desulfurase activity
M5E03_12500	COG1959	2 iron, 2 sulfur cluster binding
M5E03_12505	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5E03_12510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5E03_12525	COG0124	histidyl-tRNA synthetase
M5E03_12535	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_12535	COG3103	Sh3 type 3 domain protein
M5E03_12535	COG4991	sh3 domain protein
M5E03_12540	COG1490	D-aminoacyl-tRNA deacylase activity
M5E03_12545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E03_12550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E03_12555	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5E03_12555	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M5E03_12560	COG5416	Lipopolysaccharide assembly protein A domain
M5E03_12565	COG0490	domain, Protein
M5E03_12570	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5E03_12570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5E03_12580	COG2244	polysaccharide biosynthetic process
M5E03_12585	COG2323	membrane
M5E03_12595	COG1862	Preprotein translocase
M5E03_12600	COG0343	queuine tRNA-ribosyltransferase activity
M5E03_12605	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5E03_12615	COG2255	four-way junction helicase activity
M5E03_12620	COG0632	four-way junction helicase activity
M5E03_12630	COG2112	serine threonine protein kinase
M5E03_12645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M5E03_12660	COG1388	LysM domain
M5E03_12660	COG1388	LysM domain
M5E03_12665	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5E03_12670	COG0157	Belongs to the NadC ModD family
M5E03_12675	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M5E03_12680	COG1104	cysteine desulfurase activity
M5E03_12685	COG1827	regulation of RNA biosynthetic process
M5E03_12690	COG0077	Prephenate dehydratase
M5E03_12695	COG4492	Belongs to the UPF0735 family
M5E03_12700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M5E03_12705	COG3290	protein histidine kinase activity
M5E03_12710	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M5E03_12715	COG2868	ribosomal protein
M5E03_12720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5E03_12725	COG1994	Peptidase M50
M5E03_12730	COG0739	heme binding
M5E03_12735	COG2894	cell division
M5E03_12740	COG0850	regulation of cytokinetic process
M5E03_12745	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5E03_12755	COG1077	Cell shape determining protein MreB Mrl
M5E03_12760	COG2003	Belongs to the UPF0758 family
M5E03_12765	COG0424	maF-like protein
M5E03_12775	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
M5E03_12785	COG0285	dihydrofolate synthase activity
M5E03_12790	COG0525	valine-tRNA ligase activity
M5E03_12800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E03_12805	COG1388	LysM domain
M5E03_12810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E03_12815	COG0113	porphobilinogen synthase activity
M5E03_12820	COG1587	Uroporphyrinogen-III synthase
M5E03_12825	COG0181	hydroxymethylbilane synthase activity
M5E03_12830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5E03_12835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M5E03_12845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M5E03_12850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M5E03_12855	COG0470	DNA polymerase III
M5E03_12855	COG1067	ATP-dependent peptidase activity
M5E03_12860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5E03_12865	COG0544	peptidyl-prolyl cis-trans isomerase activity
M5E03_12870	COG0457	Tetratricopeptide repeat
M5E03_12870	COG1477	protein flavinylation
M5E03_12875	COG0066	3-isopropylmalate dehydratase activity
M5E03_12880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M5E03_12885	COG0473	3-isopropylmalate dehydrogenase activity
M5E03_12890	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E03_12895	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M5E03_12900	COG0440	acetolactate synthase activity
M5E03_12905	COG0028	Belongs to the TPP enzyme family
M5E03_12910	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_12915	COG2706	6-phosphogluconolactonase activity
M5E03_12920	COG3339	Conserved Protein
M5E03_12925	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M5E03_12930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E03_12935	COG1696	Membrane protein involved in D-alanine export
M5E03_12975	COG0622	Phosphoesterase
M5E03_12980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5E03_12985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5E03_12990	COG5401	PFAM Sporulation and spore germination
M5E03_12995	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E03_13000	COG1846	Transcriptional regulator
M5E03_13005	COG2197	response regulator
M5E03_13010	COG2851	Citrate transporter
M5E03_13015	COG0583	DNA-binding transcription factor activity
M5E03_13020	COG2828	Protein conserved in bacteria
M5E03_13030	COG0824	Thioesterase
M5E03_13035	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5E03_13040	COG1053	succinate dehydrogenase
M5E03_13045	COG2009	succinate dehydrogenase
M5E03_13050	COG1719	4-vinyl reductase, 4VR
M5E03_13055	COG0527	aspartate kinase activity
M5E03_13060	COG0322	excinuclease ABC activity
M5E03_13065	COG3118	belongs to the thioredoxin family
M5E03_13070	COG3534	alpha-L-arabinofuranosidase
M5E03_13075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M5E03_13080	COG2086	electron transfer activity
M5E03_13085	COG1024	Enoyl-CoA hydratase
M5E03_13090	COG1309	transcriptional regulator
M5E03_13095	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_13105	COG3766	membrane
M5E03_13110	COG1193	negative regulation of DNA recombination
M5E03_13115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E03_13115	COG1796	DNA polymerase
M5E03_13120	COG1286	toxin biosynthetic process
M5E03_13125	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M5E03_13130	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E03_13135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_13135	COG0072	phenylalanine-tRNA ligase activity
M5E03_13140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M5E03_13145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E03_13155	COG1966	Carbon starvation protein
M5E03_13160	COG1363	Peptidase, m42
M5E03_13170	COG3326	Membrane
M5E03_13175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M5E03_13180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M5E03_13185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5E03_13190	COG1346	cytolysis
M5E03_13200	COG3279	Response regulator of the LytR AlgR family
M5E03_13205	COG3275	phosphorelay sensor kinase activity
M5E03_13210	COG1011	Hydrolase
M5E03_13220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E03_13230	COG0398	Pfam SNARE associated Golgi protein
M5E03_13235	COG1484	DNA-dependent DNA replication
M5E03_13240	COG3611	Membrane attachment protein
M5E03_13245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5E03_13255	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M5E03_13260	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E03_13265	COG0237	dephospho-CoA kinase activity
M5E03_13270	COG1971	Probably functions as a manganese efflux pump
M5E03_13275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5E03_13280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E03_13280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E03_13285	COG5002	protein histidine kinase activity
M5E03_13290	COG0745	RESPONSE REGULATOR receiver
M5E03_13295	COG0039	L-malate dehydrogenase activity
M5E03_13300	COG0538	isocitrate dehydrogenase activity
M5E03_13305	COG0372	Belongs to the citrate synthase family
M5E03_13310	COG2707	UPF0756 membrane protein
M5E03_13315	COG0628	permease
M5E03_13320	COG3030	protein affecting phage T7 exclusion by the F plasmid
M5E03_13330	COG0205	6-phosphofructokinase activity
M5E03_13335	COG0825	malonyl-CoA metabolic process
M5E03_13340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5E03_13345	COG0281	malic enzyme
M5E03_13350	COG0587	DNA-directed DNA polymerase activity
M5E03_13370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M5E03_13380	COG4109	DRTGG domain
M5E03_13385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E03_13390	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_13400	COG0165	Argininosuccinate lyase
M5E03_13405	COG0137	argininosuccinate synthase activity
M5E03_13410	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5E03_13415	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5E03_13420	COG0827	DNA restriction-modification system
M5E03_13425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M5E03_13430	COG3874	Sporulation protein YtfJ
M5E03_13440	COG1714	RDD family
M5E03_13445	COG0616	signal peptide processing
M5E03_13450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E03_13460	COG3239	Fatty acid desaturase
M5E03_13465	COG4585	Histidine kinase
M5E03_13470	COG2197	response regulator
M5E03_13475	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_13480	COG0745	RESPONSE REGULATOR receiver
M5E03_13485	COG0642	Histidine kinase
M5E03_13490	COG0772	Belongs to the SEDS family
M5E03_13495	COG1695	Transcriptional regulator
M5E03_13500	COG1136	(ABC) transporter
M5E03_13505	COG0577	efflux transmembrane transporter activity
M5E03_13510	COG0402	S-adenosylhomocysteine deaminase activity
M5E03_13515	COG1279	arginine transmembrane transporter activity
M5E03_13520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E03_13530	COG0301	tRNA thio-modification
M5E03_13535	COG1104	cysteine desulfurase activity
M5E03_13540	COG1114	Component of the transport system for branched-chain amino acids
M5E03_13545	COG1114	Component of the transport system for branched-chain amino acids
M5E03_13550	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M5E03_13555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E03_13560	COG1309	transcriptional regulator
M5E03_13565	COG1956	GAF domain-containing protein
M5E03_13570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M5E03_13580	COG1335	isochorismatase
M5E03_13585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E03_13590	COG2329	Antibiotic biosynthesis monooxygenase
M5E03_13595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5E03_13600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E03_13605	COG0454	-acetyltransferase
M5E03_13610	COG0517	IMP dehydrogenase activity
M5E03_13615	COG0123	including yeast histone deacetylase and acetoin utilization protein
M5E03_13620	COG1609	Transcriptional regulator
M5E03_13625	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M5E03_13625	COG1605	Chorismate mutase
M5E03_13630	COG3118	belongs to the thioredoxin family
M5E03_13635	COG4980	gas vesicle protein
M5E03_13640	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M5E03_13645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E03_13650	COG1674	ftsk spoiiie
M5E03_13655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E03_13660	COG4848	Belongs to the UPF0354 family
M5E03_13665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_13680	COG1363	Peptidase, m42
M5E03_13685	COG5584	Small secreted protein
M5E03_13690	COG0281	malic enzyme
M5E03_13695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E03_13700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5E03_13710	COG0510	thiamine kinase activity
M5E03_13715	COG1597	lipid kinase activity
M5E03_13725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5E03_13730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E03_13735	COG3340	Belongs to the peptidase S51 family
M5E03_13740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E03_13745	COG2252	PERMEase
M5E03_13750	COG1349	DNA-binding transcription factor activity
M5E03_13755	COG1187	pseudouridine synthase activity
M5E03_13760	COG2244	polysaccharide biosynthetic process
M5E03_13765	COG2081	HI0933 family
M5E03_13775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5E03_13790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E03_13795	COG5578	integral membrane protein
M5E03_13800	COG0673	inositol 2-dehydrogenase activity
M5E03_13805	COG1653	transport
M5E03_13810	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M5E03_13815	COG4209	transmembrane transport
M5E03_13820	COG2207	Transcriptional regulator
M5E03_13825	COG1733	regulation of RNA biosynthetic process
M5E03_13830	COG2814	Major facilitator Superfamily
M5E03_13835	COG0656	L-ascorbic acid biosynthetic process
M5E03_13840	COG1653	transport
M5E03_13845	COG0395	ABC-type sugar transport system, permease component
M5E03_13850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E03_13855	COG1073	alpha beta
M5E03_13860	COG0495	leucyl-tRNA aminoacylation
M5E03_13870	COG2202	Pas domain
M5E03_13870	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_13875	COG2433	Pfam Transposase IS66
M5E03_13880	COG0577	efflux transmembrane transporter activity
M5E03_13885	COG1136	(ABC) transporter
M5E03_13895	COG1131	(ABC) transporter
M5E03_13900	COG1725	Transcriptional regulator
M5E03_13915	COG1242	4 iron, 4 sulfur cluster binding
M5E03_13920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M5E03_13930	COG2267	carboxylic ester hydrolase activity
M5E03_13935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5E03_13940	COG0367	asparagine synthase
M5E03_13945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M5E03_13950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M5E03_13960	COG1506	peptidase
M5E03_13965	COG1233	COG1233 Phytoene dehydrogenase and related
M5E03_13985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E03_13990	COG1116	anion transmembrane transporter activity
M5E03_13995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E03_14000	COG0494	nUDIX hydrolase
M5E03_14005	COG2310	stress, protein
M5E03_14020	COG4824	toxin secretion phage lysis holin
M5E03_14030	COG0783	Belongs to the Dps family
M5E03_14045	COG1854	S-ribosylhomocysteine lyase activity
M5E03_14050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M5E03_14055	COG0288	reversible hydration of carbon dioxide
M5E03_14060	COG3443	Belongs to the bacterial solute-binding protein 9 family
M5E03_14060	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5E03_14065	COG0254	rRNA binding
M5E03_14070	COG1271	oxidase subunit
M5E03_14075	COG1294	oxidase, subunit
M5E03_14090	COG4948	Mandelate Racemase Muconate Lactonizing
M5E03_14095	COG0318	PFAM AMP-dependent synthetase and ligase
M5E03_14100	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5E03_14105	COG0596	Alpha beta hydrolase
M5E03_14110	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M5E03_14115	COG1169	isochorismate synthase
M5E03_14120	COG1575	Belongs to the MenA family. Type 1 subfamily
M5E03_14125	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E03_14255	COG3859	Proton-coupled thiamine transporter YuaJ
M5E03_14265	COG1247	-acetyltransferase
M5E03_14270	COG2268	Band 7 protein
M5E03_14275	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E03_14280	COG2318	DinB family
M5E03_14285	COG1454	alcohol dehydrogenase
M5E03_14290	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_14295	COG1510	regulation of RNA biosynthetic process
M5E03_14310	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_14310	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E03_14355	COG3778	Protein conserved in bacteria
M5E03_14360	COG3299	homolog of phage Mu protein gp47
M5E03_14365	COG3628	GPW Gp25 family protein
M5E03_14375	COG4193	domain, Protein
M5E03_14380	COG1652	LysM domain
M5E03_14385	COG3953	SLT domain
M5E03_14385	COG5280	Phage tail tape measure protein TP901
M5E03_14435	COG4653	Phage capsid family
M5E03_14440	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5E03_14445	COG5518	Phage portal protein
M5E03_14450	COG1783	phage Terminase large subunit
M5E03_14455	COG5484	DNA packaging
M5E03_14460	COG1595	DNA-templated transcription, initiation
M5E03_14490	COG1396	sequence-specific DNA binding
M5E03_14500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5E03_14510	COG1968	undecaprenyl-diphosphatase activity
M5E03_14515	COG0628	permease
M5E03_14525	COG0673	inositol 2-dehydrogenase activity
M5E03_14530	COG0693	protein deglycase activity
M5E03_14535	COG0840	transmembrane signaling receptor activity
M5E03_14540	COG0840	transmembrane signaling receptor activity
M5E03_14545	COG0840	transmembrane signaling receptor activity
M5E03_14550	COG0840	transmembrane signaling receptor activity
M5E03_14565	COG2070	2-Nitropropane dioxygenase
M5E03_14570	COG0432	Pfam Uncharacterised protein family UPF0047
M5E03_14575	COG1253	flavin adenine dinucleotide binding
M5E03_14580	COG2738	Putative neutral zinc metallopeptidase
M5E03_14590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E03_14605	COG0166	Belongs to the GPI family
M5E03_14610	COG1979	alcohol dehydrogenase
M5E03_14615	COG1979	alcohol dehydrogenase
M5E03_14620	COG2155	Conserved Protein
M5E03_14625	COG1098	S1 RNA binding domain
M5E03_14630	COG0436	Aminotransferase
M5E03_14635	COG1522	sequence-specific DNA binding
M5E03_14640	COG2267	carboxylic ester hydrolase activity
M5E03_14650	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M5E03_14655	COG2205	protein histidine kinase activity
M5E03_14670	COG5018	Exonuclease
M5E03_14675	COG2814	Major facilitator Superfamily
M5E03_14680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_14685	COG3011	Protein conserved in bacteria
M5E03_14695	COG3290	protein histidine kinase activity
M5E03_14700	COG4565	transcriptional regulatory protein
M5E03_14705	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E03_14710	COG3845	ABC transporter
M5E03_14715	COG4603	Belongs to the binding-protein-dependent transport system permease family
M5E03_14720	COG1079	Belongs to the binding-protein-dependent transport system permease family
M5E03_14725	COG3493	citrate carrier protein
M5E03_14735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E03_14735	COG2111	Na H antiporter
M5E03_14740	COG2111	Na H antiporter
M5E03_14745	COG1006	Multisubunit Na H antiporter MnhC subunit
M5E03_14750	COG0651	ATP synthesis coupled electron transport
M5E03_14755	COG1863	multisubunit Na H antiporter MnhE subunit
M5E03_14760	COG2212	antiporter activity
M5E03_14765	COG1320	monovalent cation:proton antiporter activity
M5E03_14770	COG2050	protein possibly involved in aromatic compounds catabolism
M5E03_14775	COG2197	response regulator
M5E03_14780	COG4585	Histidine kinase
M5E03_14790	COG0142	geranyltranstransferase activity
M5E03_14805	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5E03_14810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5E03_14815	COG1335	isochorismatase
M5E03_14820	COG5506	Protein of unknown function (DUF1694)
M5E03_14840	COG0628	permease
M5E03_14855	COG1418	mRNA catabolic process
M5E03_14860	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_14870	COG1511	domain protein
M5E03_14875	COG0433	COG0433 Predicted ATPase
M5E03_14875	COG1674	ftsk spoiiie
M5E03_14880	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5E03_14885	COG5417	Belongs to the EsaB family
M5E03_14890	COG4842	Belongs to the WXG100 family
M5E03_14895	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5E03_14895	COG2508	Transcriptional regulator
M5E03_14900	COG0686	Belongs to the AlaDH PNT family
M5E03_14905	COG1268	BioY protein
M5E03_14910	COG4326	sporulation control protein
M5E03_14915	COG2056	Na+-H+ antiporter family
M5E03_14920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5E03_14925	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M5E03_14930	COG3584	3D domain protein
M5E03_14945	COG1252	NADH dehydrogenase
M5E03_14950	COG0492	ferredoxin-NADP+ reductase activity
M5E03_14960	COG0789	Transcriptional regulator
M5E03_14995	COG0316	Belongs to the HesB IscA family
M5E03_15000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M5E03_15005	COG4844	belongs to the
M5E03_15010	COG1252	NADH dehydrogenase
M5E03_15020	COG4837	Protein of unknown function (DUF1462)
M5E03_15030	COG1506	peptidase
M5E03_15030	COG4946	Tricorn protease homolog
M5E03_15030	COG0823	Involved in the tonB-independent uptake of proteins
M5E03_15035	COG0083	homoserine kinase activity
M5E03_15040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5E03_15045	COG0460	homoserine dehydrogenase
M5E03_15050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E03_15055	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E03_15060	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E03_15065	COG0647	UMP catabolic process
M5E03_15070	COG2445	Protein of unknown function DUF86
M5E03_15075	COG4470	Protein conserved in bacteria
M5E03_15085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E03_15090	COG0739	heme binding
M5E03_15100	COG3377	Domain of unknown function (DUF1805)
M5E03_15105	COG0737	Belongs to the 5'-nucleotidase family
M5E03_15110	COG1801	Protein of unknown function DUF72
M5E03_15115	COG2508	Transcriptional regulator
M5E03_15120	COG2140	Oxalate decarboxylase
M5E03_15130	COG2814	Major facilitator Superfamily
M5E03_15135	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M5E03_15140	COG2356	endonuclease I
M5E03_15150	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_15175	COG0561	phosphatase activity
M5E03_15185	COG0642	Histidine kinase
M5E03_15185	COG5002	protein histidine kinase activity
M5E03_15190	COG0745	RESPONSE REGULATOR receiver
M5E03_15195	COG2311	Membrane
M5E03_15215	COG1309	transcriptional regulator
M5E03_15220	COG0719	Fe-S assembly protein
M5E03_15225	COG0822	iron-sulfur transferase activity
M5E03_15230	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5E03_15235	COG0719	Fe-S assembly protein
M5E03_15240	COG0396	ATPase activity
M5E03_15245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E03_15250	COG1464	Belongs to the NlpA lipoprotein family
M5E03_15255	COG2011	ABC-type metal ion transport system permease component
M5E03_15260	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E03_15270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_15275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5E03_15285	COG0509	glycine decarboxylation via glycine cleavage system
M5E03_15290	COG1393	Belongs to the ArsC family
M5E03_15295	COG1960	acyl-CoA dehydrogenase activity
M5E03_15300	COG0183	Belongs to the thiolase family
M5E03_15305	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E03_15305	COG1024	Enoyl-CoA hydratase
M5E03_15320	COG5577	PFAM Coat F domain
M5E03_15330	COG1120	ATPase activity
M5E03_15340	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_15345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_15350	COG0745	RESPONSE REGULATOR receiver
M5E03_15355	COG2205	protein histidine kinase activity
M5E03_15355	COG2770	Histidine kinase
M5E03_15365	COG1309	transcriptional regulator
M5E03_15370	COG0114	fumarate hydratase activity
M5E03_15380	COG0697	spore germination
M5E03_15385	COG0814	amino acid
M5E03_15400	COG2197	response regulator
M5E03_15405	COG4585	Histidine kinase
M5E03_15410	COG4758	membrane
M5E03_15420	COG1842	Phage shock protein A
M5E03_15425	COG4758	membrane
M5E03_15430	COG2096	Adenosyltransferase
M5E03_15440	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5E03_15450	COG2204	response regulator
M5E03_15465	COG1454	alcohol dehydrogenase
M5E03_15470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E03_15475	COG1120	ATPase activity
M5E03_15480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_15495	COG2721	sulfolactate sulfo-lyase activity
M5E03_15500	COG0246	Mannitol dehydrogenase
M5E03_15505	COG1609	Transcriptional regulator
M5E03_15510	COG1904	glucuronate isomerase
M5E03_15515	COG2205	protein histidine kinase activity
M5E03_15520	COG0745	RESPONSE REGULATOR receiver
M5E03_15525	COG1120	ATPase activity
M5E03_15530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_15545	COG0531	amino acid
M5E03_15560	COG1988	membrane-bound metal-dependent
M5E03_15565	COG1368	sulfuric ester hydrolase activity
M5E03_15570	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5E03_15575	COG4149	molybdate abc transporter
M5E03_15580	COG0656	L-ascorbic acid biosynthetic process
M5E03_15585	COG1940	carbohydrate kinase activity
M5E03_15590	COG0025	NhaP-type Na H and K H
M5E03_15595	COG2860	membrane
M5E03_15600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5E03_15605	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E03_15610	COG2217	Heavy metal translocating P-type atpase
M5E03_15615	COG1121	(ABC) transporter
M5E03_15620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E03_15625	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5E03_15635	COG3226	Transcriptional regulator
M5E03_15640	COG0784	Response regulator, receiver
M5E03_15645	COG4191	Histidine kinase
M5E03_15650	COG1027	Aspartate ammonia-lyase
M5E03_15660	COG2217	Heavy metal translocating P-type atpase
M5E03_15665	COG2608	mercury ion transmembrane transporter activity
M5E03_15670	COG1937	Protein conserved in bacteria
M5E03_15695	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5E03_15700	COG0557	exoribonuclease II activity
M5E03_15705	COG1647	Serine aminopeptidase, S33
M5E03_15710	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E03_15715	COG2002	toxin-antitoxin pair type II binding
M5E03_15720	COG1476	TRANSCRIPTIONal
M5E03_15725	COG1396	sequence-specific DNA binding
M5E03_15730	COG1396	sequence-specific DNA binding
M5E03_15735	COG1733	regulation of RNA biosynthetic process
M5E03_15740	COG1174	glycine betaine transport
M5E03_15745	COG1732	Glycine betaine
M5E03_15750	COG1174	glycine betaine transport
M5E03_15755	COG0517	IMP dehydrogenase activity
M5E03_15755	COG1125	glycine betaine transport
M5E03_15760	COG1510	regulation of RNA biosynthetic process
M5E03_15765	COG2095	MarC family integral membrane protein
M5E03_15775	COG0456	acetyltransferase
M5E03_15795	COG1122	ATPase activity
M5E03_15805	COG0148	phosphopyruvate hydratase activity
M5E03_15810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5E03_15815	COG0149	triose-phosphate isomerase activity
M5E03_15820	COG0126	phosphoglycerate kinase activity
M5E03_15825	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E03_15830	COG2390	Transcriptional regulator
M5E03_15835	COG0833	amino acid
M5E03_15840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E03_15845	COG3829	transcription factor binding
M5E03_15850	COG2186	Transcriptional regulator
M5E03_15855	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M5E03_15865	COG0534	Mate efflux family protein
M5E03_15875	COG0444	Belongs to the ABC transporter superfamily
M5E03_15880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E03_15885	COG0601	transmembrane transport
M5E03_15890	COG0747	negative chemotaxis
M5E03_15895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E03_15900	COG0110	maltose O-acetyltransferase activity
M5E03_15905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E03_15910	COG2244	polysaccharide biosynthetic process
M5E03_15915	COG5039	Polysaccharide pyruvyl transferase
M5E03_15920	COG1216	Glycosyl transferase, family 2
M5E03_15930	COG0438	transferase activity, transferring glycosyl groups
M5E03_15935	COG1215	transferase activity, transferring glycosyl groups
M5E03_15940	COG0438	transferase activity, transferring glycosyl groups
M5E03_15945	COG1086	Polysaccharide biosynthesis protein
M5E03_15950	COG0489	protein tyrosine kinase activity
M5E03_15955	COG3944	biosynthesis protein
M5E03_15960	COG1396	sequence-specific DNA binding
M5E03_15970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_15975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E03_15985	COG0726	polysaccharide deacetylase
M5E03_15990	COG0488	(ABC) transporter
M5E03_16010	COG0601	transmembrane transport
M5E03_16015	COG0747	negative chemotaxis
M5E03_16020	COG1819	glycosyl
M5E03_16025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_16035	COG0740	serine-type endopeptidase activity
M5E03_16040	COG1611	Belongs to the LOG family
M5E03_16045	COG1694	Mazg nucleotide pyrophosphohydrolase
M5E03_16050	COG0659	secondary active sulfate transmembrane transporter activity
M5E03_16055	COG0288	reversible hydration of carbon dioxide
M5E03_16060	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E03_16070	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M5E03_16075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_16080	COG1481	regulation of sporulation
M5E03_16085	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M5E03_16090	COG1660	Displays ATPase and GTPase activities
M5E03_16095	COG1051	belongs to the nudix hydrolase family
M5E03_16100	COG0492	ferredoxin-NADP+ reductase activity
M5E03_16105	COG0791	NLP P60 protein
M5E03_16105	COG3883	PFAM NLP P60 protein
M5E03_16110	COG0457	Tetratricopeptide repeat
M5E03_16115	COG0140	phosphoribosyl-ATP diphosphatase activity
M5E03_16115	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5E03_16120	COG0107	imidazoleglycerol-phosphate synthase activity
M5E03_16125	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M5E03_16130	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5E03_16135	COG0131	Imidazoleglycerol-phosphate dehydratase
M5E03_16140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5E03_16145	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5E03_16150	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M5E03_16155	COG4990	cell redox homeostasis
M5E03_16170	COG2910	NAD(P)H-binding
M5E03_16175	COG1959	2 iron, 2 sulfur cluster binding
M5E03_16180	COG0110	maltose O-acetyltransferase activity
M5E03_16185	COG0546	phosphoglycolate phosphatase activity
M5E03_16190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M5E03_16200	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M5E03_16205	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M5E03_16210	COG0363	glucosamine-6-phosphate deaminase activity
M5E03_16215	COG2188	Transcriptional regulator
M5E03_16220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M5E03_16225	COG1950	PFAM Membrane protein of
M5E03_16230	COG1983	PspC domain protein
M5E03_16235	COG3595	metallopeptidase activity
M5E03_16250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5E03_16260	COG4897	Protein conserved in bacteria
M5E03_16265	COG0574	Belongs to the PEP-utilizing enzyme family
M5E03_16265	COG3848	Pyruvate phosphate dikinase
M5E03_16270	COG1309	transcriptional regulator
M5E03_16275	COG2814	Major facilitator Superfamily
M5E03_16285	COG0745	RESPONSE REGULATOR receiver
M5E03_16290	COG5002	protein histidine kinase activity
M5E03_16295	COG1113	amino acid transport
M5E03_16300	COG0778	Nitroreductase
M5E03_16305	COG1733	regulation of RNA biosynthetic process
M5E03_16310	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_16320	COG3409	Peptidoglycan-binding domain 1 protein
M5E03_16320	COG0793	Belongs to the peptidase S41A family
M5E03_16325	COG0730	response to heat
M5E03_16330	COG0791	NLP P60 protein
M5E03_16330	COG3883	PFAM NLP P60 protein
M5E03_16335	COG2177	Part of the ABC transporter FtsEX involved in
M5E03_16340	COG2884	Cell division ATP-binding protein ftsE
M5E03_16345	COG2010	Cytochrome c
M5E03_16350	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E03_16370	COG0653	protein targeting
M5E03_16375	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5E03_16380	COG0840	transmembrane signaling receptor activity
M5E03_16395	COG1516	flagellar protein fliS
M5E03_16400	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5E03_16405	COG1334	flagellar protein FlaG
M5E03_16410	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M5E03_16415	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M5E03_16425	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E03_16430	COG1256	bacterial-type flagellum assembly
M5E03_16430	COG4786	Flagellar basal body rod
M5E03_16435	COG3418	PFAM FlgN family protein
M5E03_16450	COG1040	competence protein
M5E03_16460	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M5E03_16465	COG1307	EDD domain protein, DegV family
M5E03_16470	COG2197	response regulator
M5E03_16475	COG4585	Histidine kinase
M5E03_16480	COG1739	Uncharacterized protein family UPF0029
M5E03_16485	COG1316	TRANSCRIPTIONal
M5E03_16490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5E03_16495	COG0438	transferase activity, transferring glycosyl groups
M5E03_16500	COG1215	transferase activity, transferring glycosyl groups
M5E03_16505	COG3206	protein involved in exopolysaccharide biosynthesis
M5E03_16510	COG3307	-O-antigen
M5E03_16515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E03_16520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5E03_16525	COG0297	glycogen (starch) synthase activity
M5E03_16525	COG0438	transferase activity, transferring glycosyl groups
M5E03_16530	COG2244	polysaccharide biosynthetic process
M5E03_16545	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_16545	COG2247	cell wall binding repeat
M5E03_16550	COG2247	cell wall binding repeat
M5E03_16550	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E03_16555	COG2247	cell wall binding repeat
M5E03_16555	COG2385	sporulation resulting in formation of a cellular spore
M5E03_16565	COG1316	TRANSCRIPTIONal
M5E03_16570	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5E03_16575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5E03_16580	COG1134	teichoic acid transport
M5E03_16585	COG1682	transport, permease protein
M5E03_16590	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_16595	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_16605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5E03_16610	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M5E03_16615	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_16620	COG4193	domain, Protein
M5E03_16625	COG1482	cell wall glycoprotein biosynthetic process
M5E03_16635	COG1175	transmembrane transport
M5E03_16640	COG1653	transport
M5E03_16645	COG2197	response regulator
M5E03_16650	COG2972	Histidine kinase
M5E03_16660	COG0454	-acetyltransferase
M5E03_16665	COG0800	Aldolase
M5E03_16670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E03_16675	COG1609	Transcriptional regulator
M5E03_16680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M5E03_16685	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_16690	COG0697	spore germination
M5E03_16695	COG0814	amino acid
M5E03_16710	COG2814	Major facilitator Superfamily
M5E03_16715	COG1316	TRANSCRIPTIONal
M5E03_16720	COG0561	phosphatase activity
M5E03_16725	COG0791	NLP P60 protein
M5E03_16735	COG2843	Capsule synthesis protein
M5E03_16750	COG0697	spore germination
M5E03_16765	COG1609	Transcriptional regulator
M5E03_16770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E03_16775	COG1869	D-ribose catabolic process
M5E03_16780	COG1129	ABC transporter
M5E03_16785	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5E03_16790	COG1879	ABC-type sugar transport system periplasmic component
M5E03_16795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E03_16800	COG0583	DNA-binding transcription factor activity
M5E03_16805	COG0028	Belongs to the TPP enzyme family
M5E03_16810	COG3527	Alpha-acetolactate decarboxylase
M5E03_16815	COG1522	sequence-specific DNA binding
M5E03_16820	COG2059	Chromate
M5E03_16825	COG2059	Chromate
M5E03_16830	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5E03_16840	COG4715	Zinc finger, swim domain protein
M5E03_16845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5E03_16850	COG2202	Pas domain
M5E03_16850	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E03_16855	COG0561	phosphatase activity
M5E03_16870	COG1970	mechanosensitive ion channel activity
M5E03_16875	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5E03_16880	COG0457	Tetratricopeptide repeat
M5E03_16885	COG4786	Flagellar basal body rod
M5E03_16890	COG4786	Flagellar basal body rod
M5E03_16895	COG1077	Cell shape determining protein MreB Mrl
M5E03_16900	COG1609	Transcriptional regulator
M5E03_16905	COG1846	Transcriptional regulator
M5E03_16910	COG2814	Major facilitator Superfamily
M5E03_16915	COG0671	phosphoesterase, PA-phosphatase related
M5E03_16920	COG0477	Major facilitator Superfamily
M5E03_16925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_16930	COG0765	amino acid transport
M5E03_16940	COG0004	ammonium transporteR
M5E03_16945	COG0347	Belongs to the P(II) protein family
M5E03_16950	COG0739	heme binding
M5E03_16955	COG1247	-acetyltransferase
M5E03_16970	COG0523	cobalamin synthesis protein
M5E03_16975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5E03_16980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5E03_16985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5E03_16990	COG2223	nitrite transmembrane transporter activity
M5E03_16995	COG0243	molybdopterin cofactor binding
M5E03_17000	COG2304	oxidoreductase activity
M5E03_17005	COG2304	oxidoreductase activity
M5E03_17010	COG2385	sporulation resulting in formation of a cellular spore
M5E03_17015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5E03_17025	COG4836	Membrane
M5E03_17035	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M5E03_17040	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5E03_17045	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M5E03_17050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M5E03_17055	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5E03_17060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M5E03_17065	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5E03_17070	COG0356	it plays a direct role in the translocation of protons across the membrane
M5E03_17080	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5E03_17085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5E03_17090	COG4475	Protein of unknown function (DUF436)
M5E03_17095	COG0698	ribose 5-phosphate isomerase
M5E03_17100	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E03_17105	COG1971	Probably functions as a manganese efflux pump
M5E03_17110	COG0009	L-threonylcarbamoyladenylate synthase
M5E03_17115	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5E03_17130	COG2890	protein-(glutamine-N5) methyltransferase activity
M5E03_17135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5E03_17140	COG0789	Transcriptional regulator
M5E03_17145	COG0679	Auxin Efflux Carrier
M5E03_17150	COG0281	malic enzyme
M5E03_17155	COG1435	thymidine kinase activity
M5E03_17160	COG0254	rRNA binding
M5E03_17165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M5E03_17170	COG1494	fructose-1,6-bisphosphatase
M5E03_17175	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5E03_17180	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5E03_17185	COG0191	fructose-bisphosphate aldolase activity
M5E03_17190	COG2204	response regulator
M5E03_17195	COG4821	SIS domain
M5E03_17200	COG0504	CTP synthase activity
M5E03_17205	COG3343	RNA polymerase activity
M5E03_17215	COG1960	acyl-CoA dehydrogenase activity
M5E03_17220	COG1960	acyl-CoA dehydrogenase activity
M5E03_17225	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E03_17230	COG0183	Belongs to the thiolase family
M5E03_17235	COG0247	lactate metabolic process
M5E03_17235	COG2181	nitrate reductase activity
M5E03_17240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_17245	COG4294	response to UV
M5E03_17255	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E03_17265	COG1132	(ABC) transporter
M5E03_17270	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E03_17275	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E03_17285	COG0018	arginyl-trna synthetase
M5E03_17290	COG4506	Protein conserved in bacteria
M5E03_17300	COG0010	Belongs to the arginase family
M5E03_17305	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M5E03_17310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E03_17320	COG1994	Peptidase M50
M5E03_17325	COG1942	4-Oxalocrotonate Tautomerase
M5E03_17355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_17360	COG0583	DNA-binding transcription factor activity
M5E03_17365	COG0431	NADPH-dependent FMN reductase
M5E03_17370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_17375	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5E03_17380	COG0454	-acetyltransferase
M5E03_17385	COG0765	amino acid transport
M5E03_17390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_17395	COG0765	amino acid transport
M5E03_17400	COG1126	abc transporter atp-binding protein
M5E03_17405	COG3465	dGTPase activity
M5E03_17410	COG1078	dGTPase activity
M5E03_17415	COG4844	belongs to the
M5E03_17495	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5E03_17505	COG0280	phosphate acetyltransferase
M5E03_17515	COG1073	alpha beta
M5E03_17520	COG1522	sequence-specific DNA binding
M5E03_17525	COG2814	Major facilitator Superfamily
M5E03_17530	COG0077	Prephenate dehydratase
M5E03_17540	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_17545	COG0151	Belongs to the GarS family
M5E03_17550	COG0436	Aminotransferase
M5E03_17555	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_17560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M5E03_17565	COG1091	dTDP-4-dehydrorhamnose reductase activity
M5E03_17570	COG1088	dTDP-glucose 4,6-dehydratase activity
M5E03_17575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M5E03_17580	COG3980	spore coat polysaccharide biosynthesis protein
M5E03_17585	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M5E03_17590	COG2089	acid synthase
M5E03_17595	COG0456	acetyltransferase
M5E03_17600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E03_17605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E03_17610	COG0463	Glycosyl transferase, family 2
M5E03_17630	COG2363	Small membrane protein
M5E03_17635	COG2233	PERMEase
M5E03_17645	COG1012	belongs to the aldehyde dehydrogenase family
M5E03_17650	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M5E03_17655	COG1216	Glycosyl transferase, family 2
M5E03_17665	COG0351	phosphomethylpyrimidine kinase
M5E03_17680	COG1621	beta-fructofuranosidase activity
M5E03_17685	COG1263	PTS System
M5E03_17685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_17690	COG3711	transcriptional antiterminator
M5E03_17700	COG1404	Belongs to the peptidase S8 family
M5E03_17705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E03_17710	COG0778	Nitroreductase
M5E03_17715	COG0772	Belongs to the SEDS family
M5E03_17725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E03_17730	COG1845	cytochrome c oxidase, subunit III
M5E03_17735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E03_17740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E03_17750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M5E03_17755	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E03_17760	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5E03_17775	COG2246	polysaccharide biosynthetic process
M5E03_17795	COG3162	membrane
M5E03_17800	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E03_17810	COG0352	thiamine-phosphate diphosphorylase activity
M5E03_17815	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M5E03_17820	COG0583	DNA-binding transcription factor activity
M5E03_17825	COG1380	Effector of murein hydrolase LrgA
M5E03_17830	COG1346	cytolysis
M5E03_17835	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5E03_17840	COG0346	lactoylglutathione lyase activity
M5E03_17850	COG0765	amino acid transport
M5E03_17855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E03_17860	COG0457	Tetratricopeptide repeat
M5E03_17870	COG2357	RelA SpoT domain protein
M5E03_17875	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5E03_17880	COG1129	ABC transporter
M5E03_17890	COG3420	alginic acid biosynthetic process
M5E03_17895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E03_17905	COG1486	melibiose metabolic process
M5E03_17910	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E03_17915	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_17920	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_17925	COG3711	transcriptional antiterminator
M5E03_17925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_17945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E03_17960	COG1595	DNA-templated transcription, initiation
M5E03_17970	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5E03_17975	COG4988	ABC transporter
M5E03_17980	COG1294	oxidase, subunit
M5E03_17985	COG1271	oxidase subunit
M5E03_18010	COG4509	Sortase family
M5E03_18035	COG5386	Cell surface protein
M5E03_18040	COG5386	Cell surface protein
M5E03_18045	COG1733	regulation of RNA biosynthetic process
M5E03_18050	COG2514	catechol 2,3-dioxygenase activity
M5E03_18055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_18055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E03_18060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_18060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E03_18070	COG0726	polysaccharide deacetylase
M5E03_18075	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E03_18080	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_18085	COG2723	6-phospho-beta-galactosidase activity
M5E03_18090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E03_18095	COG3711	transcriptional antiterminator
M5E03_18095	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E03_18120	COG1757	Na H antiporter
M5E03_18125	COG1027	Aspartate ammonia-lyase
M5E03_18130	COG0252	asparaginase activity
M5E03_18135	COG1396	sequence-specific DNA binding
M5E03_18160	COG4842	Belongs to the WXG100 family
M5E03_18165	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5E03_18180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E03_18185	COG2723	6-phospho-beta-galactosidase activity
M5E03_18190	COG1263	PTS System
M5E03_18190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_18190	COG2190	(PTS) system
M5E03_18195	COG3711	transcriptional antiterminator
M5E03_18200	COG3878	Protein conserved in bacteria
M5E03_18210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E03_18215	COG1122	ATPase activity
M5E03_18220	COG4721	ABC-type cobalt transport system, permease component
M5E03_18225	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E03_18260	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5E03_18265	COG0778	Nitroreductase
M5E03_18275	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M5E03_18280	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5E03_18285	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M5E03_18290	COG2390	Transcriptional regulator
M5E03_18300	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M5E03_18300	COG2755	lipolytic protein G-D-S-L family
M5E03_18320	COG0561	phosphatase activity
M5E03_18325	COG0789	Transcriptional regulator
M5E03_18330	COG0673	inositol 2-dehydrogenase activity
M5E03_18335	COG0840	transmembrane signaling receptor activity
M5E03_18340	COG1113	amino acid transport
M5E03_18345	COG4335	DNA alkylation repair
M5E03_18355	COG1070	Carbohydrate kinase
M5E03_18360	COG1737	Transcriptional regulator
M5E03_18380	COG0583	DNA-binding transcription factor activity
M5E03_18385	COG1609	Transcriptional regulator
M5E03_18390	COG2182	Extracellular solute-binding protein
M5E03_18395	COG1175	transmembrane transport
M5E03_18400	COG3833	ABC-type maltose transport systems, permease component
M5E03_18410	COG1874	Beta-galactosidase
M5E03_18415	COG2851	Citrate transporter
M5E03_18425	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5E03_18430	COG1131	(ABC) transporter
M5E03_18435	COG2824	Alkylphosphonate utilization operon protein PhnA
M5E03_18440	COG1929	Belongs to the glycerate kinase type-1 family
M5E03_18445	COG2610	gluconate transmembrane transporter activity
M5E03_18450	COG3835	regulator
M5E03_18455	COG1309	transcriptional regulator
M5E03_18460	COG2814	Major facilitator Superfamily
M5E03_18470	COG1136	(ABC) transporter
M5E03_18470	COG0577	efflux transmembrane transporter activity
M5E03_18475	COG0457	Tetratricopeptide repeat
M5E03_18480	COG3711	transcriptional antiterminator
M5E03_18485	COG2723	6-phospho-beta-galactosidase activity
M5E03_18490	COG2190	(PTS) system
M5E03_18490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E03_18490	COG1263	PTS System
M5E03_18525	COG1113	amino acid transport
M5E03_18530	COG1609	Transcriptional regulator
M5E03_18535	COG2814	Major facilitator Superfamily
M5E03_18545	COG2814	Major facilitator Superfamily
M5E03_18565	COG5444	nuclease activity
M5E03_18580	COG2723	6-phospho-beta-galactosidase activity
M5E03_18590	COG2188	Transcriptional regulator
M5E03_18600	COG0384	phenazine biosynthesis protein PhzF
M5E03_18605	COG0583	DNA-binding transcription factor activity
M5E03_18625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5E03_18635	COG2814	Major facilitator Superfamily
M5E03_18640	COG0640	Transcriptional regulator
M5E03_18660	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M5E03_18670	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E03_18680	COG4720	Psort location CytoplasmicMembrane, score
M5E03_18700	COG0456	acetyltransferase
M5E03_18705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E03_18710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M5E03_18715	COG4853	Protein conserved in bacteria
M5E03_18720	COG4863	YycH protein
M5E03_18725	COG5002	protein histidine kinase activity
M5E03_18730	COG0745	RESPONSE REGULATOR receiver
M5E03_18755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E03_18765	COG2311	Membrane
M5E03_18770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5E03_18775	COG0346	lactoylglutathione lyase activity
M5E03_18780	COG0305	Participates in initiation and elongation during chromosome replication
M5E03_18800	COG2819	hydrolase of the alpha beta superfamily
M5E03_18805	COG1028	Short-chain dehydrogenase reductase Sdr
M5E03_18810	COG1169	isochorismate synthase
M5E03_18815	COG1021	2,3-dihydroxybenzoate-AMP ligase
M5E03_18820	COG1535	isochorismatase
M5E03_18820	COG3433	isochorismatase activity
M5E03_18825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E03_18830	COG3251	PFAM MbtH domain protein
M5E03_18835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_18835	COG2207	Transcriptional regulator
M5E03_18840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E03_18845	COG2819	hydrolase of the alpha beta superfamily
M5E03_18850	COG3093	addiction module antidote protein HigA
M5E03_18855	COG2807	transmembrane transport
M5E03_18860	COG0359	binds to the 23S rRNA
M5E03_18865	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M5E03_18870	COG4241	membrane
M5E03_18875	COG1227	inorganic diphosphatase activity
M5E03_18885	COG1595	DNA-templated transcription, initiation
M5E03_18895	COG0753	catalase activity
M5E03_18900	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5E03_18905	COG0400	carboxylic ester hydrolase activity
M5E03_18910	COG0346	lactoylglutathione lyase activity
M5E03_18915	COG1174	glycine betaine transport
M5E03_18920	COG0517	IMP dehydrogenase activity
M5E03_18920	COG1125	glycine betaine transport
M5E03_18925	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M5E03_18930	COG0629	single-stranded DNA binding
M5E03_18935	COG0360	Binds together with S18 to 16S ribosomal RNA
M5E03_18940	COG0012	GTP binding
M5E03_18945	COG4481	Protein conserved in bacteria
M5E03_18960	COG3949	Membrane
M5E03_18970	COG1475	DNA binding
M5E03_18975	COG1192	Involved in chromosome partitioning
M5E03_18980	COG1475	DNA binding
M5E03_18985	COG0357	Ribosomal RNA small subunit methyltransferase G
M5E03_18990	COG0445	tRNA wobble uridine modification
M5E03_18995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M5E03_19000	COG1847	R3H domain protein
M5E03_19005	COG0706	membrane insertase activity
M5E03_19010	COG0594	ribonuclease P activity
M5E03_19015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M5E03_19040	COG0457	Tetratricopeptide repeat