locus-tag	class	description
M5E02_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M5E02_00010	COG0592	DNA-directed DNA polymerase activity
M5E02_00015	COG2501	S4 domain
M5E02_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M5E02_00030	COG0187	DNA topoisomerase II activity
M5E02_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5E02_00070	COG0516	GMP reductase activity
M5E02_00070	COG0517	IMP dehydrogenase activity
M5E02_00075	COG1686	Belongs to the peptidase S11 family
M5E02_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E02_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
M5E02_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
M5E02_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M5E02_00110	COG1428	Deoxynucleoside kinase
M5E02_00115	COG1428	Deoxynucleoside kinase
M5E02_00120	COG3858	chitin binding
M5E02_00120	COG1388	LysM domain
M5E02_00125	COG1335	isochorismatase
M5E02_00130	COG0590	tRNA wobble adenosine to inosine editing
M5E02_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M5E02_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M5E02_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M5E02_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
M5E02_00200	COG3853	Toxic anion resistance protein (TelA)
M5E02_00205	COG1982	Orn Lys Arg decarboxylase major
M5E02_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M5E02_00215	COG3870	Protein conserved in bacteria
M5E02_00220	COG1728	Protein conserved in bacteria
M5E02_00225	COG0470	DNA polymerase III
M5E02_00230	COG1774	PSP1 C-terminal conserved region
M5E02_00235	COG4467	Involved in initiation control of chromosome replication
M5E02_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
M5E02_00245	COG2827	Endonuclease containing a URI domain
M5E02_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M5E02_00255	COG2002	toxin-antitoxin pair type II binding
M5E02_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E02_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E02_00265	COG0084	hydrolase, TatD family'
M5E02_00270	COG3583	domain protein
M5E02_00270	COG3584	3D domain protein
M5E02_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5E02_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M5E02_00290	COG4466	Protein conserved in bacteria
M5E02_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
M5E02_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E02_00310	COG0251	oxidation-reduction process
M5E02_00315	COG2088	sporulation resulting in formation of a cellular spore
M5E02_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
M5E02_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M5E02_00335	COG0193	aminoacyl-tRNA hydrolase activity
M5E02_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M5E02_00350	COG2002	toxin-antitoxin pair type II binding
M5E02_00355	COG2244	polysaccharide biosynthetic process
M5E02_00360	COG3956	TIGRFAM MazG family protein
M5E02_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
M5E02_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M5E02_00385	COG1098	S1 RNA binding domain
M5E02_00400	COG2208	phosphoserine phosphatase activity
M5E02_00405	COG2304	oxidoreductase activity
M5E02_00410	COG0515	serine threonine protein kinase
M5E02_00415	COG0037	tRNA processing
M5E02_00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
M5E02_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M5E02_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
M5E02_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
M5E02_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E02_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E02_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
M5E02_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
M5E02_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E02_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
M5E02_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
M5E02_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
M5E02_00480	COG1396	sequence-specific DNA binding
M5E02_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E02_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
M5E02_00570	COG4463	regulation of RNA biosynthetic process
M5E02_00575	COG3880	PFAM UvrB UvrC protein
M5E02_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
M5E02_00585	COG0542	response to heat
M5E02_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M5E02_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
M5E02_00600	COG4956	integral membrane protein (PIN domain superfamily)
M5E02_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
M5E02_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
M5E02_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M5E02_00620	COG1045	serine acetyltransferase
M5E02_00625	COG0215	cysteine-tRNA ligase activity
M5E02_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
M5E02_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E02_00640	COG3688	RNA-binding protein containing a PIN domain
M5E02_00645	COG1595	DNA-templated transcription, initiation
M5E02_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E02_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E02_00660	COG0250	Participates in transcription elongation, termination and antitermination
M5E02_00670	COG0081	regulation of translation
M5E02_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M5E02_00680	COG0222	ribosome binding
M5E02_00685	COG2813	Specifically methylates the guanine in position
M5E02_00690	COG0085	RNA polymerase activity
M5E02_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M5E02_00700	COG1358	cellular component organization or biogenesis
M5E02_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M5E02_00710	COG0049	tRNA binding
M5E02_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M5E02_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M5E02_00725	COG0596	Alpha beta hydrolase
M5E02_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M5E02_00740	COG0088	Forms part of the polypeptide exit tunnel
M5E02_00745	COG0089	rRNA binding
M5E02_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M5E02_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M5E02_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M5E02_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M5E02_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
M5E02_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M5E02_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M5E02_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M5E02_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M5E02_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5E02_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M5E02_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M5E02_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M5E02_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M5E02_00825	COG1841	ribosomal large subunit assembly
M5E02_00830	COG0200	Binds to the 23S rRNA
M5E02_00835	COG0201	protein transport
M5E02_00840	COG0563	adenylate kinase activity
M5E02_00845	COG0024	Methionine aminopeptidase
M5E02_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M5E02_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M5E02_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M5E02_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M5E02_00875	COG0202	RNA polymerase activity
M5E02_00880	COG0203	ribosomal protein L17
M5E02_00885	COG1122	ATPase activity
M5E02_00890	COG1122	ATPase activity
M5E02_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E02_00900	COG0101	tRNA pseudouridine synthase activity
M5E02_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M5E02_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M5E02_00925	COG0464	growth
M5E02_00935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E02_00960	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E02_00965	COG0489	protein tyrosine kinase activity
M5E02_00975	COG2194	sulfuric ester hydrolase activity
M5E02_00980	COG0726	polysaccharide deacetylase
M5E02_01015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E02_01020	COG0385	Bile acid
M5E02_01025	COG3876	Protein conserved in bacteria
M5E02_01030	COG1472	Belongs to the glycosyl hydrolase 3 family
M5E02_01035	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5E02_01040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_01040	COG1263	PTS System
M5E02_01045	COG1737	Transcriptional regulator
M5E02_01050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
M5E02_01085	COG1595	DNA-templated transcription, initiation
M5E02_01090	COG5662	AntiSigma factor
M5E02_01095	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5E02_01100	COG4856	YbbR-like protein
M5E02_01105	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E02_01110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
M5E02_01130	COG1131	(ABC) transporter
M5E02_01155	COG3402	PFAM membrane-flanked domain
M5E02_01160	COG1131	(ABC) transporter
M5E02_01215	COG2311	Membrane
M5E02_01235	COG1113	amino acid transport
M5E02_01240	COG0584	glycerophosphoryl diester phosphodiesterase
M5E02_01245	COG2271	Major facilitator Superfamily
M5E02_01255	COG1331	Highly conserved protein containing a thioredoxin domain
M5E02_01265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E02_01275	COG1937	Protein conserved in bacteria
M5E02_01280	COG2210	Belongs to the sulfur carrier protein TusA family
M5E02_01290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E02_01290	COG0425	Belongs to the sulfur carrier protein TusA family
M5E02_01295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E02_01295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E02_01300	COG0425	Belongs to the sulfur carrier protein TusA family
M5E02_01305	COG0730	response to heat
M5E02_01315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E02_01320	COG2814	Major facilitator Superfamily
M5E02_01330	COG1846	Transcriptional regulator
M5E02_01340	COG1683	Conserved Protein
M5E02_01350	COG0656	L-ascorbic acid biosynthetic process
M5E02_01355	COG1054	Belongs to the UPF0176 family
M5E02_01360	COG0531	amino acid
M5E02_01370	COG3711	transcriptional antiterminator
M5E02_01375	COG1263	PTS System
M5E02_01375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_01375	COG2190	(PTS) system
M5E02_01380	COG2723	6-phospho-beta-galactosidase activity
M5E02_01400	COG3711	transcriptional antiterminator
M5E02_01400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_01405	COG1940	carbohydrate kinase activity
M5E02_01410	COG0383	alpha-mannosidase activity
M5E02_01415	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_01420	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_01430	COG1404	Belongs to the peptidase S8 family
M5E02_01440	COG0833	amino acid
M5E02_01445	COG2040	homocysteine
M5E02_01450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E02_01455	COG1695	Transcriptional regulator
M5E02_01470	COG2814	Major facilitator Superfamily
M5E02_01475	COG0456	acetyltransferase
M5E02_01490	COG1404	Belongs to the peptidase S8 family
M5E02_01500	COG1309	transcriptional regulator
M5E02_01505	COG1917	Cupin 2, conserved barrel domain protein
M5E02_01510	COG1063	alcohol dehydrogenase
M5E02_01515	COG1846	Transcriptional regulator
M5E02_01520	COG0318	PFAM AMP-dependent synthetase and ligase
M5E02_01525	COG0531	amino acid
M5E02_01535	COG0596	Alpha beta hydrolase
M5E02_01540	COG1115	amino acid carrier protein
M5E02_01545	COG2066	Belongs to the glutaminase family
M5E02_01550	COG4191	Histidine kinase
M5E02_01555	COG0784	Response regulator, receiver
M5E02_01560	COG3012	SEC-C Motif Domain Protein
M5E02_01560	COG1405	negative regulation of cell septum assembly
M5E02_01570	COG2197	response regulator
M5E02_01575	COG4585	Histidine kinase
M5E02_01585	COG0667	Aldo Keto reductase
M5E02_01590	COG3290	protein histidine kinase activity
M5E02_01595	COG3279	Response regulator of the LytR AlgR family
M5E02_01600	COG4555	ABC transporter
M5E02_01605	COG1668	transmembrane transport
M5E02_01625	COG3773	Cell wall hydrolase
M5E02_01630	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_01645	COG2310	stress, protein
M5E02_01650	COG2310	stress, protein
M5E02_01655	COG2310	stress, protein
M5E02_01660	COG0861	Integral membrane protein TerC family
M5E02_01690	COG3853	Toxic anion resistance protein (TelA)
M5E02_01695	COG0517	IMP dehydrogenase activity
M5E02_01695	COG4175	Glycine betaine
M5E02_01700	COG4176	ABC-type proline glycine betaine transport system permease component
M5E02_01705	COG2113	Glycine betaine
M5E02_01720	COG1473	amidohydrolase
M5E02_01725	COG1288	antiporter activity
M5E02_01730	COG0039	L-malate dehydrogenase activity
M5E02_01735	COG1620	l-lactate permease
M5E02_01740	COG1609	Transcriptional regulator
M5E02_01745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E02_01750	COG0561	phosphatase activity
M5E02_01755	COG0673	inositol 2-dehydrogenase activity
M5E02_01760	COG0738	Major facilitator superfamily
M5E02_01765	COG1280	lysine exporter protein (LysE YggA)
M5E02_01775	COG3403	YqcI/YcgG family
M5E02_01780	COG1113	amino acid transport
M5E02_01785	COG3665	Urea carboxylase-associated protein
M5E02_01790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
M5E02_01810	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_01815	COG0710	3-dehydroquinate dehydratase activity
M5E02_01820	COG0028	Belongs to the TPP enzyme family
M5E02_01830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
M5E02_01835	COG2271	Major facilitator Superfamily
M5E02_01850	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
M5E02_01855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E02_01865	COG0477	Major facilitator Superfamily
M5E02_01870	COG2226	methyltransferase
M5E02_01875	COG0583	DNA-binding transcription factor activity
M5E02_01880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E02_01885	COG3458	cephalosporin-C deacetylase activity
M5E02_01895	COG3541	Predicted nucleotidyltransferase
M5E02_01900	COG0506	proline dehydrogenase activity
M5E02_01905	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_01910	COG2508	Transcriptional regulator
M5E02_01915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
M5E02_01920	COG0765	amino acid transport
M5E02_01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_01935	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E02_01940	COG1522	sequence-specific DNA binding
M5E02_01945	COG2746	aminoglycoside 3-N-acetyltransferase activity
M5E02_01955	COG0840	transmembrane signaling receptor activity
M5E02_01955	COG3290	protein histidine kinase activity
M5E02_01960	COG3209	COG3209 Rhs family protein
M5E02_01980	COG3842	ATPase activity
M5E02_01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E02_02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E02_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E02_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
M5E02_02035	COG4555	ABC transporter
M5E02_02050	COG0697	spore germination
M5E02_02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E02_02070	COG2364	Membrane
M5E02_02075	COG0737	Belongs to the 5'-nucleotidase family
M5E02_02080	COG3764	Sortase (surface protein transpeptidase)
M5E02_02085	COG2002	toxin-antitoxin pair type II binding
M5E02_02090	COG1126	abc transporter atp-binding protein
M5E02_02095	COG0765	amino acid transport
M5E02_02100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_02105	COG0833	amino acid
M5E02_02110	COG3104	oligopeptide transport
M5E02_02115	COG5434	Belongs to the glycosyl hydrolase 28 family
M5E02_02120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_02125	COG0456	acetyltransferase
M5E02_02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_02135	COG0765	amino acid transport
M5E02_02140	COG1126	abc transporter atp-binding protein
M5E02_02145	COG1473	amidohydrolase
M5E02_02150	COG2079	MmgE PrpD family protein
M5E02_02155	COG0745	RESPONSE REGULATOR receiver
M5E02_02160	COG5002	protein histidine kinase activity
M5E02_02160	COG3850	Histidine kinase
M5E02_02165	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_02170	COG0527	aspartate kinase activity
M5E02_02175	COG2814	Major facilitator Superfamily
M5E02_02180	COG1309	transcriptional regulator
M5E02_02190	COG0640	Transcriptional regulator
M5E02_02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E02_02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
M5E02_02205	COG0531	amino acid
M5E02_02210	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_02215	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E02_02220	COG4549	nuclear export factor GLE1
M5E02_02225	COG2372	response to copper ion
M5E02_02225	COG1276	copper resistance
M5E02_02230	COG2213	PTS system mannitol-specific
M5E02_02235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_02240	COG0246	Mannitol dehydrogenase
M5E02_02245	COG0840	transmembrane signaling receptor activity
M5E02_02265	COG0346	lactoylglutathione lyase activity
M5E02_02275	COG0561	phosphatase activity
M5E02_02280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
M5E02_02285	COG1914	H( )-stimulated, divalent metal cation uptake system
M5E02_02290	COG4336	lyase activity
M5E02_02295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
M5E02_02300	COG1984	allophanate hydrolase subunit 2
M5E02_02305	COG1414	Transcriptional regulator
M5E02_02310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5E02_02315	COG2755	lipolytic protein G-D-S-L family
M5E02_02325	COG3711	transcriptional antiterminator
M5E02_02330	COG2226	methyltransferase
M5E02_02335	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_02340	COG3871	stress protein (general stress protein 26)
M5E02_02360	COG2814	Major facilitator Superfamily
M5E02_02365	COG1802	Transcriptional regulator
M5E02_02370	COG1917	Cupin 2, conserved barrel domain protein
M5E02_02370	COG2207	Transcriptional regulator
M5E02_02375	COG0697	spore germination
M5E02_02380	COG0473	3-isopropylmalate dehydrogenase activity
M5E02_02385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5E02_02385	COG0551	DNA topoisomerase type I activity
M5E02_02390	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
M5E02_02395	COG3706	GGDEF domain
M5E02_02400	COG5298	Protein conserved in bacteria
M5E02_02405	COG1215	transferase activity, transferring glycosyl groups
M5E02_02415	COG0531	amino acid
M5E02_02420	COG0028	Belongs to the TPP enzyme family
M5E02_02425	COG5444	nuclease activity
M5E02_02445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E02_02450	COG1914	H( )-stimulated, divalent metal cation uptake system
M5E02_02455	COG2261	transglycosylase associated protein
M5E02_02460	COG2217	Heavy metal translocating P-type atpase
M5E02_02465	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
M5E02_02470	COG3290	protein histidine kinase activity
M5E02_02475	COG4565	transcriptional regulatory protein
M5E02_02480	COG1301	dicarboxylic acid transport
M5E02_02485	COG0628	permease
M5E02_02490	COG1301	dicarboxylic acid transport
M5E02_02495	COG1131	(ABC) transporter
M5E02_02500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5E02_02515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_02520	COG1181	Belongs to the D-alanine--D-alanine ligase family
M5E02_02525	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M5E02_02540	COG0513	Belongs to the DEAD box helicase family
M5E02_02545	COG3402	PFAM membrane-flanked domain
M5E02_02550	COG3428	Bacterial PH domain
M5E02_02555	COG0705	Rhomboid family
M5E02_02560	COG0736	holo-[acyl-carrier-protein] synthase activity
M5E02_02565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M5E02_02570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E02_02575	COG0864	Transcriptional regulator
M5E02_02580	COG2337	Toxic component of a toxin-antitoxin (TA) module
M5E02_02585	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_02590	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_02595	COG2172	sigma factor antagonist activity
M5E02_02600	COG2208	phosphoserine phosphatase activity
M5E02_02605	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_02610	COG2172	sigma factor antagonist activity
M5E02_02615	COG1191	sigma factor activity
M5E02_02620	COG2208	phosphoserine phosphatase activity
M5E02_02625	COG2183	response to ionizing radiation
M5E02_02635	COG3091	SprT-like family
M5E02_02640	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E02_02645	COG0022	dehydrogenase e1 component
M5E02_02650	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E02_02655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E02_02660	COG3284	Transcriptional regulator
M5E02_02705	COG0456	acetyltransferase
M5E02_02705	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M5E02_02710	COG1278	Cold shock
M5E02_02715	COG1329	Transcriptional regulator
M5E02_02720	COG1064	alcohol dehydrogenase
M5E02_02725	COG0789	Transcriptional regulator
M5E02_02740	COG0477	Major facilitator Superfamily
M5E02_02745	COG0657	acetylesterase activity
M5E02_02755	COG4221	oxidoreductase activity
M5E02_02770	COG1404	Belongs to the peptidase S8 family
M5E02_02775	COG0252	asparaginase activity
M5E02_02795	COG2814	Major facilitator Superfamily
M5E02_02800	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
M5E02_02805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E02_02835	COG1309	transcriptional regulator
M5E02_02840	COG1846	Transcriptional regulator
M5E02_02845	COG0778	Nitroreductase
M5E02_02860	COG1396	sequence-specific DNA binding
M5E02_02870	COG0456	acetyltransferase
M5E02_02880	COG4122	O-methyltransferase activity
M5E02_02890	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
M5E02_02895	COG0697	spore germination
M5E02_02905	COG1301	dicarboxylic acid transport
M5E02_02945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
M5E02_02950	COG0802	atpase or kinase
M5E02_02955	COG1214	PFAM Peptidase M22, glycoprotease
M5E02_02960	COG0456	acetyltransferase
M5E02_02965	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M5E02_02970	COG0488	(ABC) transporter
M5E02_02975	COG0315	cyclic pyranopterin monophosphate synthase activity
M5E02_02980	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
M5E02_02985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M5E02_02990	COG0805	protein transport
M5E02_03005	COG1266	CAAX protease self-immunity
M5E02_03010	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M5E02_03015	COG0459	protein refolding
M5E02_03025	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5E02_03060	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M5E02_03065	COG0823	Involved in the tonB-independent uptake of proteins
M5E02_03075	COG2132	Multicopper oxidase
M5E02_03080	COG1113	amino acid transport
M5E02_03085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5E02_03090	COG0714	Associated with various cellular activities
M5E02_03095	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
M5E02_03100	COG1305	Transglutaminase-like
M5E02_03105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
M5E02_03105	COG0519	Catalyzes the synthesis of GMP from XMP
M5E02_03110	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
M5E02_03115	COG2207	Transcriptional regulator
M5E02_03115	COG1917	Cupin 2, conserved barrel domain protein
M5E02_03120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E02_03125	COG2207	Transcriptional regulator
M5E02_03150	COG1595	DNA-templated transcription, initiation
M5E02_03160	COG2814	Major facilitator Superfamily
M5E02_03165	COG0583	DNA-binding transcription factor activity
M5E02_03170	COG2252	PERMEase
M5E02_03185	COG3064	Membrane
M5E02_03190	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
M5E02_03200	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
M5E02_03205	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
M5E02_03210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
M5E02_03215	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M5E02_03220	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E02_03225	COG0047	phosphoribosylformylglycinamidine synthase activity
M5E02_03230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
M5E02_03235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
M5E02_03240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
M5E02_03245	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
M5E02_03250	COG0138	bifunctional purine biosynthesis protein purh
M5E02_03255	COG0151	Belongs to the GarS family
M5E02_03275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E02_03280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
M5E02_03285	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
M5E02_03290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E02_03300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5E02_03305	COG4496	protein, YerC YecD
M5E02_03315	COG0069	glutamate synthase activity
M5E02_03335	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
M5E02_03340	COG0210	DNA helicase
M5E02_03345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M5E02_03350	COG4851	CamS sex pheromone cAM373 precursor
M5E02_03365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E02_03370	COG1285	pathogenesis
M5E02_03375	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E02_03380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E02_03385	COG0154	amidase activity
M5E02_03390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M5E02_03395	COG1309	transcriptional regulator
M5E02_03400	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E02_03405	COG1957	nucleoside hydrolase
M5E02_03410	COG1597	lipid kinase activity
M5E02_03415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5E02_03420	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M5E02_03430	COG1737	Transcriptional regulator
M5E02_03435	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_03435	COG1263	PTS System
M5E02_03440	COG1486	melibiose metabolic process
M5E02_03450	COG1959	2 iron, 2 sulfur cluster binding
M5E02_03455	COG0492	ferredoxin-NADP+ reductase activity
M5E02_03470	COG1486	melibiose metabolic process
M5E02_03480	COG2211	Major facilitator Superfamily
M5E02_03510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
M5E02_03515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E02_03520	COG1442	glycosyl transferase family 8
M5E02_03525	COG1216	Glycosyl transferase, family 2
M5E02_03530	COG1442	glycosyl transferase family 8
M5E02_03535	COG2223	nitrite transmembrane transporter activity
M5E02_03545	COG0471	metal ion transport
M5E02_03560	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E02_03575	COG0531	amino acid
M5E02_03580	COG0463	Glycosyl transferase, family 2
M5E02_03585	COG0488	(ABC) transporter
M5E02_03590	COG1469	GTP cyclohydrolase I activity
M5E02_03595	COG0789	Transcriptional regulator
M5E02_03600	COG2814	Major facilitator Superfamily
M5E02_03605	COG0488	(ABC) transporter
M5E02_03610	COG0513	Belongs to the DEAD box helicase family
M5E02_03615	COG2130	NADP-dependent
M5E02_03640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E02_03640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E02_03645	COG1262	PFAM Formylglycine-generating sulfatase enzyme
M5E02_03655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E02_03655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E02_03665	COG3290	protein histidine kinase activity
M5E02_03670	COG4565	transcriptional regulatory protein
M5E02_03675	COG3181	Tripartite tricarboxylate transporter family receptor
M5E02_03685	COG2851	Citrate transporter
M5E02_03695	COG3479	Phenolic acid decarboxylase
M5E02_03700	COG1695	Transcriptional regulator
M5E02_03705	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
M5E02_03710	COG0477	Major facilitator Superfamily
M5E02_03715	COG0583	DNA-binding transcription factor activity
M5E02_03720	COG1254	Belongs to the acylphosphatase family
M5E02_03725	COG2258	MOSC domain
M5E02_03740	COG0024	Methionine aminopeptidase
M5E02_03745	COG1263	PTS System
M5E02_03745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_03750	COG3739	integral membrane protein
M5E02_03765	COG1368	sulfuric ester hydrolase activity
M5E02_03770	COG0076	glutamate decarboxylase activity
M5E02_03775	COG0840	transmembrane signaling receptor activity
M5E02_03785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_03785	COG1263	PTS System
M5E02_03790	COG0366	Alpha amylase catalytic
M5E02_03795	COG2188	Transcriptional regulator
M5E02_03805	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5E02_03810	COG0737	Belongs to the 5'-nucleotidase family
M5E02_03815	COG0693	protein deglycase activity
M5E02_03820	COG4840	Belongs to the UPF0435 family
M5E02_03825	COG1115	amino acid carrier protein
M5E02_03830	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E02_03835	COG4980	gas vesicle protein
M5E02_03840	COG1295	ribonuclease BN
M5E02_03845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E02_03850	COG0477	Major facilitator Superfamily
M5E02_03860	COG0387	Pfam Sodium calcium exchanger
M5E02_03870	COG0217	transcriptional regulatory protein
M5E02_03875	COG0668	transmembrane transport
M5E02_03880	COG0535	radical SAM domain protein
M5E02_03890	COG0726	polysaccharide deacetylase
M5E02_03895	COG0598	Magnesium transport protein CorA
M5E02_03905	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
M5E02_03910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
M5E02_03920	COG0583	DNA-binding transcription factor activity
M5E02_03925	COG1942	4-Oxalocrotonate Tautomerase
M5E02_03930	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E02_03935	COG0789	Transcriptional regulator
M5E02_03940	COG2814	Major facilitator Superfamily
M5E02_03950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E02_03990	COG2076	Multidrug Resistance protein
M5E02_03995	COG2076	Multidrug Resistance protein
M5E02_04000	COG1309	transcriptional regulator
M5E02_04010	COG4637	Psort location Cytoplasmic, score
M5E02_04015	COG2755	lipolytic protein G-D-S-L family
M5E02_04020	COG0492	ferredoxin-NADP+ reductase activity
M5E02_04025	COG2169	Transcriptional regulator
M5E02_04030	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_04035	COG1132	(ABC) transporter
M5E02_04040	COG1742	UPF0060 membrane protein
M5E02_04045	COG1595	DNA-templated transcription, initiation
M5E02_04060	COG2318	DinB family
M5E02_04070	COG1846	Transcriptional regulator
M5E02_04075	COG0392	lysyltransferase activity
M5E02_04075	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
M5E02_04095	COG0778	Nitroreductase
M5E02_04110	COG1090	epimerase
M5E02_04115	COG2137	regulation of response to DNA damage stimulus
M5E02_04140	COG0463	Glycosyl transferase, family 2
M5E02_04145	COG4485	Bacterial membrane protein, YfhO
M5E02_04155	COG2140	Oxalate decarboxylase
M5E02_04165	COG1191	sigma factor activity
M5E02_04175	COG1988	membrane-bound metal-dependent
M5E02_04180	COG1194	a g-specific adenine glycosylase
M5E02_04190	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_04205	COG3557	Belongs to the UPF0374 family
M5E02_04210	COG1132	(ABC) transporter
M5E02_04215	COG0444	Belongs to the ABC transporter superfamily
M5E02_04220	COG4608	Belongs to the ABC transporter superfamily
M5E02_04225	COG0747	negative chemotaxis
M5E02_04230	COG0601	transmembrane transport
M5E02_04235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E02_04240	COG4129	membrane
M5E02_04245	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E02_04250	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
M5E02_04255	COG0735	belongs to the Fur family
M5E02_04400	COG1368	sulfuric ester hydrolase activity
M5E02_04405	COG0681	Belongs to the peptidase S26 family
M5E02_04410	COG2873	o-acetylhomoserine
M5E02_04420	COG1116	anion transmembrane transporter activity
M5E02_04425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E02_04430	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E02_04445	COG1131	(ABC) transporter
M5E02_04475	COG3382	B3 4 domain protein
M5E02_04480	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M5E02_04490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
M5E02_04500	COG2766	serine protein kinase
M5E02_04505	COG2718	Belongs to the UPF0229 family
M5E02_04510	COG1566	PFAM secretion protein HlyD family protein
M5E02_04515	COG2814	Major facilitator Superfamily
M5E02_04520	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5E02_04530	COG1278	Cold shock
M5E02_04535	COG3706	GGDEF domain
M5E02_04560	COG5577	PFAM Coat F domain
M5E02_04565	COG5002	protein histidine kinase activity
M5E02_04570	COG1525	nuclease
M5E02_04570	COG4085	toxin activity
M5E02_04570	COG0737	Belongs to the 5'-nucleotidase family
M5E02_04575	COG3764	Sortase (surface protein transpeptidase)
M5E02_04580	COG0564	pseudouridine synthase activity
M5E02_04590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
M5E02_04595	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
M5E02_04595	COG3153	acetyltransferase
M5E02_04610	COG3835	regulator
M5E02_04615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
M5E02_04620	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
M5E02_04625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
M5E02_04630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
M5E02_04635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
M5E02_04640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
M5E02_04645	COG4585	Histidine kinase
M5E02_04645	COG2203	Gaf domain
M5E02_04650	COG2197	response regulator
M5E02_04670	COG0753	catalase activity
M5E02_04675	COG1959	2 iron, 2 sulfur cluster binding
M5E02_04680	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
M5E02_04680	COG1017	nitric oxide dioxygenase activity
M5E02_04685	COG2719	SpoVR family
M5E02_04690	COG1785	Belongs to the alkaline phosphatase family
M5E02_04695	COG1388	LysM domain
M5E02_04695	COG0791	NLP P60 protein
M5E02_04700	COG0531	amino acid
M5E02_04715	COG1595	DNA-templated transcription, initiation
M5E02_04720	COG0204	Acyl-transferase
M5E02_04725	COG1253	flavin adenine dinucleotide binding
M5E02_04730	COG0789	Transcriptional regulator
M5E02_04735	COG1253	flavin adenine dinucleotide binding
M5E02_04745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E02_04750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
M5E02_04755	COG0584	glycerophosphoryl diester phosphodiesterase
M5E02_04765	COG0668	transmembrane transport
M5E02_04770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
M5E02_04775	COG0726	polysaccharide deacetylase
M5E02_04780	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E02_04785	COG0589	response to stress
M5E02_04790	COG1132	(ABC) transporter
M5E02_04795	COG1132	(ABC) transporter
M5E02_04800	COG0702	epimerase
M5E02_04810	COG3842	ATPase activity
M5E02_04815	COG2508	Transcriptional regulator
M5E02_04825	COG0189	ligase activity
M5E02_04830	COG0189	ligase activity
M5E02_04835	COG4399	Belongs to the UPF0754 family
M5E02_04840	COG3679	Belongs to the UPF0342 family
M5E02_04845	COG0561	phosphatase activity
M5E02_04850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E02_04860	COG0475	glutathione-regulated potassium exporter activity
M5E02_04865	COG0490	domain, Protein
M5E02_04880	COG1024	Enoyl-CoA hydratase
M5E02_04890	COG0420	3'-5' exonuclease activity
M5E02_04895	COG4717	serine-type aminopeptidase activity
M5E02_04900	COG3481	metal-dependent phosphohydrolase, HD sub domain
M5E02_04910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M5E02_04940	COG1846	Transcriptional regulator
M5E02_04945	COG4980	gas vesicle protein
M5E02_04960	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
M5E02_04965	COG0537	adenosine 5'-monophosphoramidase activity
M5E02_04970	COG1131	(ABC) transporter
M5E02_04975	COG4473	ABC transporter
M5E02_04985	COG1473	amidohydrolase
M5E02_04995	COG2329	Antibiotic biosynthesis monooxygenase
M5E02_05000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E02_05005	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
M5E02_05010	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M5E02_05015	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
M5E02_05020	COG1309	transcriptional regulator
M5E02_05025	COG1511	domain protein
M5E02_05030	COG1363	Peptidase, m42
M5E02_05035	COG1301	dicarboxylic acid transport
M5E02_05045	COG1234	tRNA 3'-trailer cleavage
M5E02_05050	COG0095	Lipoate-protein ligase
M5E02_05055	COG0318	PFAM AMP-dependent synthetase and ligase
M5E02_05065	COG0501	Belongs to the peptidase M48B family
M5E02_05070	COG1404	Belongs to the peptidase S8 family
M5E02_05075	COG0406	alpha-ribazole phosphatase activity
M5E02_05080	COG0840	transmembrane signaling receptor activity
M5E02_05085	COG0723	plastoquinol--plastocyanin reductase activity
M5E02_05085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
M5E02_05090	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_05100	COG4903	ComK protein
M5E02_05115	COG2732	(Barnase) inhibitor
M5E02_05120	COG1316	TRANSCRIPTIONal
M5E02_05130	COG0398	Pfam SNARE associated Golgi protein
M5E02_05135	COG0681	Belongs to the peptidase S26 family
M5E02_05140	COG3180	Ammonia monooxygenase
M5E02_05150	COG0501	Belongs to the peptidase M48B family
M5E02_05155	COG2259	Doxx family
M5E02_05160	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
M5E02_05165	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
M5E02_05170	COG1074	ATP-dependent DNA helicase activity
M5E02_05175	COG0420	3'-5' exonuclease activity
M5E02_05180	COG0419	ATPase involved in DNA repair
M5E02_05185	COG1403	HNH endonuclease
M5E02_05225	COG5337	Spore coat protein CotH
M5E02_05230	COG0179	Fumarylacetoacetate (FAA) hydrolase
M5E02_05245	COG0367	asparagine synthase
M5E02_05260	COG1562	ergosterol biosynthetic process
M5E02_05265	COG0534	Mate efflux family protein
M5E02_05270	COG1917	Cupin 2, conserved barrel domain protein
M5E02_05270	COG2207	Transcriptional regulator
M5E02_05300	COG0076	glutamate decarboxylase activity
M5E02_05335	COG1410	methionine synthase
M5E02_05335	COG0646	methionine synthase
M5E02_05340	COG0646	methionine synthase
M5E02_05340	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
M5E02_05345	COG1666	GTP binding
M5E02_05350	COG2996	Protein conserved in bacteria
M5E02_05355	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E02_05360	COG0840	transmembrane signaling receptor activity
M5E02_05365	COG1307	EDD domain protein, DegV family
M5E02_05370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E02_05390	COG0561	phosphatase activity
M5E02_05395	COG1073	alpha beta
M5E02_05400	COG2151	metal-sulfur cluster biosynthetic enzyme
M5E02_05405	COG0277	FAD linked oxidase domain protein
M5E02_05410	COG2271	Major facilitator Superfamily
M5E02_05415	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
M5E02_05420	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
M5E02_05425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
M5E02_05430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E02_05435	COG0505	Belongs to the CarA family
M5E02_05440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E02_05445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
M5E02_05455	COG2814	Major facilitator Superfamily
M5E02_05465	COG2267	carboxylic ester hydrolase activity
M5E02_05475	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E02_05490	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5E02_05495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M5E02_05500	COG5504	Zn-dependent protease
M5E02_05505	COG0444	Belongs to the ABC transporter superfamily
M5E02_05510	COG4608	Belongs to the ABC transporter superfamily
M5E02_05520	COG0601	transmembrane transport
M5E02_05525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E02_05535	COG0180	Tryptophanyl-tRNA synthetase
M5E02_05540	COG4166	transmembrane transport
M5E02_05545	COG0601	transmembrane transport
M5E02_05550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E02_05555	COG0444	Belongs to the ABC transporter superfamily
M5E02_05560	COG4608	Belongs to the ABC transporter superfamily
M5E02_05575	COG0456	acetyltransferase
M5E02_05580	COG1393	Belongs to the ArsC family
M5E02_05585	COG0861	Integral membrane protein TerC family
M5E02_05590	COG4862	establishment of competence for transformation
M5E02_05595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E02_05600	COG4469	Competence protein
M5E02_05605	COG1164	Oligoendopeptidase f
M5E02_05615	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5E02_05620	COG2346	COG2346, Truncated hemoglobins
M5E02_05625	COG0741	lytic transglycosylase activity
M5E02_05630	COG4116	CYTH
M5E02_05640	COG2357	RelA SpoT domain protein
M5E02_05645	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E02_05650	COG0564	pseudouridine synthase activity
M5E02_05655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
M5E02_05660	COG0475	glutathione-regulated potassium exporter activity
M5E02_05660	COG0569	domain protein
M5E02_05665	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E02_05670	COG0352	thiamine-phosphate diphosphorylase activity
M5E02_05680	COG2104	thiamine diphosphate biosynthetic process
M5E02_05685	COG2022	thiamine diphosphate biosynthetic process
M5E02_05690	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E02_05695	COG0351	phosphomethylpyrimidine kinase
M5E02_05700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M5E02_05755	COG0210	DNA helicase
M5E02_05770	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5E02_05775	COG2382	esterase
M5E02_05780	COG0626	cystathionine gamma-synthase activity
M5E02_05785	COG0626	cystathionine gamma-synthase activity
M5E02_05800	COG0825	malonyl-CoA metabolic process
M5E02_05830	COG0300	oxidoreductase activity
M5E02_05850	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
M5E02_05855	COG3173	Aminoglycoside phosphotransferase
M5E02_05860	COG0583	DNA-binding transcription factor activity
M5E02_05880	COG0583	DNA-binding transcription factor activity
M5E02_05885	COG2807	transmembrane transport
M5E02_05905	COG0457	Tetratricopeptide repeat
M5E02_05925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M5E02_05945	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E02_05950	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E02_05970	COG4195	phage-related replication protein
M5E02_05975	COG2856	Zn peptidase
M5E02_05980	COG3409	Peptidoglycan-binding domain 1 protein
M5E02_05980	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E02_05995	COG0306	phosphate transporter
M5E02_06000	COG1392	Phosphate transport regulator
M5E02_06010	COG0405	Gamma-glutamyltransferase
M5E02_06015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
M5E02_06025	COG4208	sulfate ABC transporter
M5E02_06030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
M5E02_06040	COG3775	system Galactitol-specific IIC component
M5E02_06055	COG1063	alcohol dehydrogenase
M5E02_06060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E02_06065	COG0022	dehydrogenase e1 component
M5E02_06065	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E02_06070	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E02_06075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E02_06080	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_06085	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_06090	COG2390	Transcriptional regulator
M5E02_06100	COG0531	amino acid
M5E02_06105	COG0346	lactoylglutathione lyase activity
M5E02_06110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E02_06115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E02_06120	COG2362	D-Aminopeptidase
M5E02_06125	COG0601	transmembrane transport
M5E02_06130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E02_06135	COG0444	Belongs to the ABC transporter superfamily
M5E02_06140	COG4166	transmembrane transport
M5E02_06145	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E02_06150	COG4948	Mandelate Racemase Muconate Lactonizing
M5E02_06155	COG0791	NLP P60 protein
M5E02_06160	COG4608	Belongs to the ABC transporter superfamily
M5E02_06165	COG1834	amidinotransferase
M5E02_06170	COG1607	acyl-coa hydrolase
M5E02_06175	COG1695	Transcriptional regulator
M5E02_06190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E02_06195	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5E02_06205	COG2076	Multidrug Resistance protein
M5E02_06210	COG2076	Multidrug Resistance protein
M5E02_06220	COG0788	formyltetrahydrofolate deformylase activity
M5E02_06225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5E02_06230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5E02_06235	COG0457	Tetratricopeptide repeat
M5E02_06245	COG1764	response to oxidative stress
M5E02_06250	COG1846	Transcriptional regulator
M5E02_06255	COG1764	response to oxidative stress
M5E02_06260	COG0590	tRNA wobble adenosine to inosine editing
M5E02_06265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E02_06270	COG1404	Belongs to the peptidase S8 family
M5E02_06275	COG0745	RESPONSE REGULATOR receiver
M5E02_06280	COG3850	Histidine kinase
M5E02_06280	COG5002	protein histidine kinase activity
M5E02_06285	COG3212	peptidase
M5E02_06290	COG3212	peptidase
M5E02_06300	COG2239	Acts as a magnesium transporter
M5E02_06310	COG0583	DNA-binding transcription factor activity
M5E02_06320	COG0789	Transcriptional regulator
M5E02_06335	COG1846	Transcriptional regulator
M5E02_06340	COG3300	MHYT domain
M5E02_06340	COG5001	Diguanylate cyclase
M5E02_06345	COG0586	Pfam SNARE associated Golgi protein
M5E02_06355	COG1191	sigma factor activity
M5E02_06375	COG0501	Belongs to the peptidase M48B family
M5E02_06380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
M5E02_06385	COG2323	membrane
M5E02_06400	COG3594	Acyltransferase
M5E02_06405	COG5002	protein histidine kinase activity
M5E02_06410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
M5E02_06420	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
M5E02_06425	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
M5E02_06430	COG0436	Aminotransferase
M5E02_06435	COG1850	ribulose-bisphosphate carboxylase activity
M5E02_06440	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
M5E02_06445	COG0235	Class ii aldolase
M5E02_06450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
M5E02_06460	COG3852	Histidine kinase
M5E02_06465	COG1846	Transcriptional regulator
M5E02_06470	COG1360	Flagellar Motor Protein
M5E02_06475	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
M5E02_06480	COG0542	response to heat
M5E02_06485	COG3949	Membrane
M5E02_06490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M5E02_06495	COG0720	synthase
M5E02_06500	COG0602	queuosine metabolic process
M5E02_06505	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M5E02_06520	COG4873	Protein conserved in bacteria
M5E02_06530	COG3773	Cell wall hydrolase
M5E02_06535	COG2244	polysaccharide biosynthetic process
M5E02_06540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_06545	COG2217	Heavy metal translocating P-type atpase
M5E02_06550	COG0006	proline dipeptidase activity
M5E02_06560	COG1609	Transcriptional regulator
M5E02_06565	COG3711	transcriptional antiterminator
M5E02_06570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_06570	COG1263	PTS System
M5E02_06570	COG2190	(PTS) system
M5E02_06575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_06580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M5E02_06590	COG1533	DNA photolyase activity
M5E02_06595	COG0840	transmembrane signaling receptor activity
M5E02_06605	COG2084	Dehydrogenase
M5E02_06610	COG2340	Cysteine-rich secretory protein family
M5E02_06615	COG0768	penicillin binding
M5E02_06620	COG4191	Histidine kinase
M5E02_06625	COG0436	Aminotransferase
M5E02_06630	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M5E02_06640	COG1714	RDD family
M5E02_06650	COG0835	chemotaxis
M5E02_06650	COG0784	Response regulator, receiver
M5E02_06665	COG1917	Cupin 2, conserved barrel domain protein
M5E02_06665	COG2207	Transcriptional regulator
M5E02_06670	COG0697	spore germination
M5E02_06680	COG2814	Major facilitator Superfamily
M5E02_06685	COG1376	ErfK ybiS ycfS ynhG family protein
M5E02_06690	COG1408	metallophosphoesterase
M5E02_06695	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_06700	COG2200	EAL domain
M5E02_06705	COG3546	catalase activity
M5E02_06710	COG4703	Protein of unknown function (DUF1797)
M5E02_06715	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
M5E02_06725	COG0517	IMP dehydrogenase activity
M5E02_06730	COG0583	DNA-binding transcription factor activity
M5E02_06735	COG0716	FMN binding
M5E02_06745	COG0716	FMN binding
M5E02_06750	COG2171	N-acyltransferase activity
M5E02_06755	COG1473	amidohydrolase
M5E02_06765	COG0668	transmembrane transport
M5E02_06770	COG0450	alkyl hydroperoxide reductase
M5E02_06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_06790	COG0746	molybdenum cofactor guanylyltransferase activity
M5E02_06795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
M5E02_06800	COG0303	'Molybdopterin
M5E02_06805	COG1763	Mo-molybdopterin cofactor biosynthetic process
M5E02_06810	COG0314	molybdopterin synthase activity
M5E02_06815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
M5E02_06830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
M5E02_06835	COG1136	(ABC) transporter
M5E02_06840	COG0577	efflux transmembrane transporter activity
M5E02_06845	COG1349	DNA-binding transcription factor activity
M5E02_06850	COG1105	Belongs to the carbohydrate kinase PfkB family
M5E02_06855	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_06855	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_06855	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_06870	COG0488	(ABC) transporter
M5E02_06875	COG2309	aminopeptidase activity
M5E02_06885	COG1077	Cell shape determining protein MreB Mrl
M5E02_06890	COG2002	toxin-antitoxin pair type II binding
M5E02_06895	COG3852	Histidine kinase
M5E02_06900	COG2105	PFAM AIG2 family protein
M5E02_06900	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
M5E02_06905	COG0569	domain protein
M5E02_06910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
M5E02_06915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E02_06920	COG5503	Protein of unknown function (DUF1447)
M5E02_06925	COG0561	phosphatase activity
M5E02_06930	COG0242	peptide deformylase activity
M5E02_06945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E02_06950	COG0022	dehydrogenase e1 component
M5E02_06955	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E02_06960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E02_06965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_06975	COG1982	Orn Lys Arg decarboxylase major
M5E02_06980	COG4476	Belongs to the UPF0223 family
M5E02_06985	COG4493	Belongs to the UPF0637 family
M5E02_06995	COG0483	inositol monophosphate 1-phosphatase activity
M5E02_07010	COG1595	DNA-templated transcription, initiation
M5E02_07030	COG1217	gtp-binding protein TYPA
M5E02_07040	COG4896	Protein conserved in bacteria
M5E02_07050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
M5E02_07055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
M5E02_07060	COG2066	Belongs to the glutaminase family
M5E02_07065	COG4838	Belongs to the UPF0358 family
M5E02_07070	COG0772	Belongs to the SEDS family
M5E02_07075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
M5E02_07080	COG0415	Belongs to the DNA photolyase family
M5E02_07085	COG1612	heme a metabolic process
M5E02_07090	COG0109	protoheme IX farnesyltransferase activity
M5E02_07095	COG2010	Cytochrome c
M5E02_07095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E02_07100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E02_07105	COG1845	cytochrome c oxidase, subunit III
M5E02_07110	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E02_07115	COG3336	cytochrome c oxidase
M5E02_07125	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
M5E02_07130	COG2340	Cysteine-rich secretory protein family
M5E02_07150	COG3679	Belongs to the UPF0342 family
M5E02_07155	COG4471	UPF0298 protein
M5E02_07160	COG0742	ribosomal rna small subunit methyltransferase
M5E02_07165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
M5E02_07170	COG3314	Sporulation integral membrane protein YlbJ
M5E02_07175	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E02_07180	COG3480	Lon protease (S16) C-terminal proteolytic domain
M5E02_07190	COG1399	metal-binding, possibly nucleic acid-binding protein
M5E02_07195	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M5E02_07205	COG0454	-acetyltransferase
M5E02_07210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
M5E02_07215	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
M5E02_07220	COG2001	Belongs to the MraZ family
M5E02_07225	COG0275	rRNA processing
M5E02_07230	COG4839	cell division protein FtsL
M5E02_07235	COG0768	penicillin binding
M5E02_07240	COG0768	penicillin binding
M5E02_07245	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M5E02_07250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5E02_07255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5E02_07260	COG0772	Belongs to the SEDS family
M5E02_07265	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5E02_07270	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M5E02_07275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M5E02_07280	COG3879	Bacterial protein of unknown function (DUF881)
M5E02_07285	COG3879	Bacterial protein of unknown function (DUF881)
M5E02_07290	COG3856	small basic protein
M5E02_07295	COG0849	cell division
M5E02_07300	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M5E02_07305	COG1404	Belongs to the peptidase S8 family
M5E02_07305	COG4412	M6 family metalloprotease domain protein
M5E02_07315	COG1191	sigma factor activity
M5E02_07320	COG1191	sigma factor activity
M5E02_07325	COG2390	Transcriptional regulator
M5E02_07340	COG3730	PTS system glucitol sorbitol-specific
M5E02_07345	COG3732	PTS system glucitol sorbitol-specific
M5E02_07355	COG1119	ATPase activity
M5E02_07360	COG1873	PFAM PRC-barrel domain
M5E02_07365	COG1496	oxidoreductase activity
M5E02_07370	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
M5E02_07375	COG1799	cell septum assembly
M5E02_07380	COG0762	integral membrane protein
M5E02_07385	COG2302	S4 RNA-binding domain
M5E02_07390	COG3599	regulation of cell shape
M5E02_07395	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M5E02_07400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E02_07405	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M5E02_07410	COG0564	pseudouridine synthase activity
M5E02_07415	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
M5E02_07420	COG2233	PERMEase
M5E02_07425	COG0540	Belongs to the ATCase OTCase family
M5E02_07430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
M5E02_07435	COG0505	Belongs to the CarA family
M5E02_07440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
M5E02_07445	COG0543	2 iron, 2 sulfur cluster binding
M5E02_07450	COG0167	dihydroorotate dehydrogenase activity
M5E02_07455	COG0284	orotidine-5'-phosphate decarboxylase activity
M5E02_07460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
M5E02_07470	COG0175	sulfate reduction
M5E02_07475	COG0306	phosphate transporter
M5E02_07480	COG2046	Belongs to the sulfate adenylyltransferase family
M5E02_07485	COG0529	Catalyzes the synthesis of activated sulfate
M5E02_07490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
M5E02_07495	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
M5E02_07500	COG1648	precorrin-2 dehydrogenase activity
M5E02_07510	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
M5E02_07515	COG1561	YicC-like family, N-terminal region
M5E02_07520	COG2052	Domain of unknown function (DUF370)
M5E02_07525	COG0194	GDP metabolic process
M5E02_07530	COG1758	RNA polymerase activity
M5E02_07535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E02_07540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M5E02_07545	COG0242	peptide deformylase activity
M5E02_07550	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M5E02_07555	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
M5E02_07555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E02_07560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
M5E02_07565	COG0631	protein serine/threonine phosphatase activity
M5E02_07570	COG2815	serine threonine protein kinase
M5E02_07570	COG0515	serine threonine protein kinase
M5E02_07575	COG1162	GTPase activity
M5E02_07580	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E02_07585	COG1564	THIamine pyrophosphokinase
M5E02_07595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M5E02_07600	COG1302	Protein conserved in bacteria
M5E02_07605	COG1461	Dihydroxyacetone kinase
M5E02_07610	COG1760	l-serine dehydratase
M5E02_07615	COG1760	l-serine dehydratase
M5E02_07620	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M5E02_07625	COG1349	DNA-binding transcription factor activity
M5E02_07630	COG0416	fatty acid biosynthetic process
M5E02_07635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M5E02_07640	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_07645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E02_07655	COG1196	nuclear chromosome segregation
M5E02_07660	COG0552	protein localization to endoplasmic reticulum
M5E02_07665	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
M5E02_07670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M5E02_07675	COG0228	four-way junction DNA binding
M5E02_07680	COG1837	Belongs to the UPF0109 family
M5E02_07690	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M5E02_07695	COG0336	Belongs to the RNA methyltransferase TrmD family
M5E02_07700	COG0335	large ribosomal subunit rRNA binding
M5E02_07705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5E02_07710	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E02_07715	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E02_07730	COG0640	Transcriptional regulator
M5E02_07745	COG2257	FlhB HrpN YscU SpaS Family
M5E02_07750	COG0045	succinate-CoA ligase (ADP-forming) activity
M5E02_07755	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M5E02_07760	COG0758	DNA mediated transformation
M5E02_07765	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M5E02_07770	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
M5E02_07775	COG4974	Belongs to the 'phage' integrase family
M5E02_07780	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M5E02_07785	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M5E02_07790	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5E02_07795	COG1815	bacterial-type flagellum-dependent cell motility
M5E02_07800	COG1558	bacterial-type flagellum-dependent cell motility
M5E02_07805	COG1677	Flagellar hook-basal body complex protein FliE
M5E02_07810	COG1766	The M ring may be actively involved in energy transduction
M5E02_07815	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E02_07820	COG1317	bacterial-type flagellum organization
M5E02_07825	COG1157	protein secretion by the type III secretion system
M5E02_07830	COG2882	bacterial-type flagellum organization
M5E02_07835	COG3334	PFAM MgtE intracellular
M5E02_07840	COG3144	bacterial-type flagellum assembly
M5E02_07845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
M5E02_07850	COG4786	Flagellar basal body rod
M5E02_07855	COG1582	Flagellar protein (FlbD)
M5E02_07860	COG1580	Controls the rotational direction of flagella during chemotaxis
M5E02_07865	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E02_07870	COG1776	CheC inhibitor of MCP methylation
M5E02_07870	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
M5E02_07875	COG2201	protein-glutamate methylesterase activity
M5E02_07880	COG3190	flagellar
M5E02_07885	COG1338	Plays a role in the flagellum-specific transport system
M5E02_07890	COG1987	bacterial-type flagellum assembly
M5E02_07895	COG1684	flagellar biosynthetic protein fliR
M5E02_07900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5E02_07905	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
M5E02_07910	COG1419	protein localization to endoplasmic reticulum
M5E02_07915	COG0455	bacterial-type flagellum organization
M5E02_07920	COG2201	protein-glutamate methylesterase activity
M5E02_07925	COG2198	Histidine kinase
M5E02_07925	COG0643	Histidine kinase
M5E02_07930	COG0835	chemotaxis
M5E02_07935	COG1776	CheC inhibitor of MCP methylation
M5E02_07940	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
M5E02_07945	COG1191	sigma factor activity
M5E02_07960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M5E02_07965	COG0528	UMP kinase activity
M5E02_07970	COG0233	cytoplasmic translational termination
M5E02_07975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M5E02_07980	COG4589	Belongs to the CDS family
M5E02_07985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
M5E02_07990	COG0750	zinc metalloprotease
M5E02_07995	COG0442	prolyl-tRNA aminoacylation
M5E02_08000	COG2176	DNA-directed DNA polymerase activity
M5E02_08015	COG3693	PFAM glycoside hydrolase, family 10
M5E02_08025	COG0779	Required for maturation of 30S ribosomal subunits
M5E02_08030	COG0195	Participates in both transcription termination and antitermination
M5E02_08035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
M5E02_08040	COG1358	cellular component organization or biogenesis
M5E02_08045	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M5E02_08050	COG1550	Protein conserved in bacteria
M5E02_08055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M5E02_08060	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M5E02_08065	COG0196	riboflavin kinase activity
M5E02_08070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M5E02_08075	COG1185	polyribonucleotide nucleotidyltransferase activity
M5E02_08080	COG0726	polysaccharide deacetylase
M5E02_08085	COG0612	Peptidase, M16
M5E02_08090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E02_08100	COG1132	(ABC) transporter
M5E02_08105	COG1132	(ABC) transporter
M5E02_08140	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
M5E02_08160	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_08165	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_08170	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E02_08175	COG1260	myo-inositol-1-phosphate synthase
M5E02_08220	COG0367	asparagine synthase
M5E02_08225	COG1873	PFAM PRC-barrel domain
M5E02_08230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E02_08235	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
M5E02_08240	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M5E02_08245	COG0527	aspartate kinase activity
M5E02_08255	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E02_08260	COG0740	serine-type endopeptidase activity
M5E02_08270	COG1674	ftsk spoiiie
M5E02_08270	COG4980	gas vesicle protein
M5E02_08275	COG2188	Transcriptional regulator
M5E02_08280	COG2814	Major facilitator Superfamily
M5E02_08285	COG2409	Drug exporters of the RND superfamily
M5E02_08285	COG1033	growth of symbiont in host cell
M5E02_08290	COG0612	Peptidase, M16
M5E02_08295	COG0612	Peptidase, M16
M5E02_08305	COG1033	growth of symbiont in host cell
M5E02_08305	COG2409	Drug exporters of the RND superfamily
M5E02_08310	COG0300	oxidoreductase activity
M5E02_08325	COG1426	Protein conserved in bacteria
M5E02_08330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M5E02_08335	COG1058	Belongs to the CinA family
M5E02_08335	COG1546	Belongs to the CinA family
M5E02_08340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M5E02_08345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M5E02_08350	COG1418	mRNA catabolic process
M5E02_08355	COG1692	metallophosphoesterase
M5E02_08360	COG2359	stage V sporulation protein S
M5E02_08365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M5E02_08370	COG1063	alcohol dehydrogenase
M5E02_08375	COG0156	8-amino-7-oxononanoate synthase activity
M5E02_08380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E02_08385	COG4550	Control of competence regulator ComK, YlbF/YmcA
M5E02_08395	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M5E02_08400	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M5E02_08425	COG1329	Transcriptional regulator
M5E02_08430	COG4195	phage-related replication protein
M5E02_08435	COG0457	Tetratricopeptide repeat
M5E02_08440	COG1404	Belongs to the peptidase S8 family
M5E02_08445	COG4195	phage-related replication protein
M5E02_08450	COG1764	response to oxidative stress
M5E02_08455	COG2076	Multidrug Resistance protein
M5E02_08485	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M5E02_08490	COG1923	regulation of RNA biosynthetic process
M5E02_08505	COG1780	Probably involved in ribonucleotide reductase function
M5E02_08510	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E02_08515	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
M5E02_08520	COG4112	unkown
M5E02_08530	COG0464	growth
M5E02_08535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
M5E02_08540	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
M5E02_08545	COG0789	Transcriptional regulator
M5E02_08550	COG0174	glutamine synthetase
M5E02_08580	COG0457	Tetratricopeptide repeat
M5E02_08585	COG5444	nuclease activity
M5E02_08610	COG5646	InterPro IPR014922
M5E02_08615	COG0457	Tetratricopeptide repeat
M5E02_08620	COG3619	membrane
M5E02_08625	COG3285	dna ligase
M5E02_08625	COG1793	dna ligase
M5E02_08630	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
M5E02_08635	COG4876	unkown
M5E02_08645	COG1959	2 iron, 2 sulfur cluster binding
M5E02_08650	COG0702	epimerase
M5E02_08655	COG0247	lactate metabolic process
M5E02_08660	COG1139	Iron-sulfur cluster binding protein
M5E02_08665	COG1556	Lactate utilization protein
M5E02_08685	COG2323	membrane
M5E02_08690	COG1309	transcriptional regulator
M5E02_08695	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E02_08695	COG2124	cytochrome p450
M5E02_08700	COG3591	Belongs to the peptidase S1B family
M5E02_08705	COG3209	COG3209 Rhs family protein
M5E02_08710	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_08725	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
M5E02_08730	COG1388	LysM domain
M5E02_08735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M5E02_08740	COG4224	UPF0291 protein
M5E02_08745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
M5E02_08755	COG3763	UPF0154 protein
M5E02_08765	COG0785	Cytochrome C biogenesis protein
M5E02_08770	COG4846	Membrane protein involved in cytochrome C biogenesis
M5E02_08780	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E02_08795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M5E02_08800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_08820	COG0824	Thioesterase
M5E02_08830	COG4841	protein insertion into membrane
M5E02_08835	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
M5E02_08840	COG1832	CoA-binding protein
M5E02_08845	COG0187	DNA topoisomerase II activity
M5E02_08850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M5E02_08860	COG0738	Major facilitator superfamily
M5E02_08875	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E02_08885	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_08890	COG1312	Catalyzes the dehydration of D-mannonate
M5E02_08895	COG1802	Transcriptional regulator
M5E02_08900	COG0673	inositol 2-dehydrogenase activity
M5E02_08910	COG1904	glucuronate isomerase
M5E02_08915	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E02_08920	COG1733	regulation of RNA biosynthetic process
M5E02_08925	COG1082	Xylose isomerase domain protein TIM barrel
M5E02_08930	COG0673	inositol 2-dehydrogenase activity
M5E02_08935	COG1082	Xylose isomerase domain protein TIM barrel
M5E02_08940	COG2814	Major facilitator Superfamily
M5E02_08950	COG2814	Major facilitator Superfamily
M5E02_08955	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_08965	COG3718	enzyme involved in inositol metabolism
M5E02_08970	COG3962	Belongs to the TPP enzyme family
M5E02_08975	COG1349	DNA-binding transcription factor activity
M5E02_08980	COG0191	fructose-bisphosphate aldolase activity
M5E02_08985	COG2197	response regulator
M5E02_08990	COG4585	Histidine kinase
M5E02_08995	COG2409	Drug exporters of the RND superfamily
M5E02_09000	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E02_09005	COG0251	oxidation-reduction process
M5E02_09045	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
M5E02_09060	COG0583	DNA-binding transcription factor activity
M5E02_09085	COG0657	acetylesterase activity
M5E02_09090	COG0789	Transcriptional regulator
M5E02_09100	COG2205	protein histidine kinase activity
M5E02_09105	COG0745	RESPONSE REGULATOR receiver
M5E02_09115	COG3507	Belongs to the glycosyl hydrolase 43 family
M5E02_09120	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_09125	COG1082	Xylose isomerase domain protein TIM barrel
M5E02_09130	COG1486	melibiose metabolic process
M5E02_09135	COG0395	ABC-type sugar transport system, permease component
M5E02_09140	COG1175	transmembrane transport
M5E02_09145	COG1653	transport
M5E02_09150	COG1609	Transcriptional regulator
M5E02_09155	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
M5E02_09170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_09175	COG0583	DNA-binding transcription factor activity
M5E02_09180	COG1053	succinate dehydrogenase
M5E02_09220	COG1846	Transcriptional regulator
M5E02_09225	COG2814	Major facilitator Superfamily
M5E02_09235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_09235	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_09235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_09240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_09240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_09240	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
M5E02_09245	COG1105	Belongs to the carbohydrate kinase PfkB family
M5E02_09255	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E02_09285	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
M5E02_09290	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
M5E02_09295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E02_09300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E02_09305	COG1024	Enoyl-CoA hydratase
M5E02_09310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E02_09315	COG0511	ligase activity, forming carbon-carbon bonds
M5E02_09320	COG0439	Biotin carboxylase
M5E02_09325	COG0318	PFAM AMP-dependent synthetase and ligase
M5E02_09330	COG1960	acyl-CoA dehydrogenase activity
M5E02_09335	COG1649	PFAM Uncharacterised BCR, COG1649
M5E02_09340	COG2365	Tyrosine phosphatase family
M5E02_09345	COG1349	DNA-binding transcription factor activity
M5E02_09355	COG3835	regulator
M5E02_09360	COG0277	FAD linked oxidase domain protein
M5E02_09365	COG0247	lactate metabolic process
M5E02_09390	COG0166	Belongs to the GPI family
M5E02_09400	COG0586	Pfam SNARE associated Golgi protein
M5E02_09405	COG1587	Uroporphyrinogen-III synthase
M5E02_09415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_09430	COG0534	Mate efflux family protein
M5E02_09435	COG2027	D-alanyl-D-alanine carboxypeptidase
M5E02_09440	COG4677	pectinesterase activity
M5E02_09445	COG2323	membrane
M5E02_09450	COG0493	'glutamate synthase
M5E02_09455	COG0067	glutamate synthase
M5E02_09455	COG0069	glutamate synthase activity
M5E02_09455	COG0070	glutamate synthase
M5E02_09460	COG0583	DNA-binding transcription factor activity
M5E02_09470	COG1132	(ABC) transporter
M5E02_09475	COG4978	Transcriptional regulator
M5E02_09475	COG0789	Transcriptional regulator
M5E02_09480	COG0454	-acetyltransferase
M5E02_09485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
M5E02_09490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
M5E02_09495	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
M5E02_09510	COG0243	molybdopterin cofactor binding
M5E02_09520	COG1070	Carbohydrate kinase
M5E02_09525	COG2115	Belongs to the xylose isomerase family
M5E02_09530	COG1940	carbohydrate kinase activity
M5E02_09540	COG2211	Major facilitator Superfamily
M5E02_09545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E02_09550	COG1994	Peptidase M50
M5E02_09570	COG1309	transcriptional regulator
M5E02_09575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E02_09580	COG3708	Transcriptional regulator
M5E02_09585	COG2378	regulation of single-species biofilm formation
M5E02_09595	COG0640	Transcriptional regulator
M5E02_09600	COG0531	amino acid
M5E02_09605	COG0741	lytic transglycosylase activity
M5E02_09610	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
M5E02_09615	COG2079	MmgE PrpD family protein
M5E02_09620	COG0372	Belongs to the citrate synthase family
M5E02_09625	COG2322	membrane
M5E02_09635	COG3584	3D domain protein
M5E02_09635	COG1388	LysM domain
M5E02_09640	COG0514	ATP-dependent DNA helicase (RecQ)
M5E02_09650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E02_09675	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_09680	COG1657	PFAM Prenyltransferase squalene oxidase
M5E02_09685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E02_09690	COG0385	Bile acid
M5E02_09695	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E02_09700	COG0567	Dehydrogenase, E1 component
M5E02_09705	COG4548	von Willebrand factor, type A
M5E02_09710	COG0714	Associated with various cellular activities
M5E02_09715	COG2032	superoxide dismutase activity
M5E02_09720	COG0791	NLP P60 protein
M5E02_09720	COG1388	LysM domain
M5E02_09725	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
M5E02_09730	COG0534	Mate efflux family protein
M5E02_09735	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E02_09740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E02_09750	COG2962	Rard protein
M5E02_09765	COG1733	regulation of RNA biosynthetic process
M5E02_09770	COG0778	Nitroreductase
M5E02_09780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E02_09785	COG0793	Belongs to the peptidase S41A family
M5E02_09785	COG3409	Peptidoglycan-binding domain 1 protein
M5E02_09790	COG2226	methyltransferase
M5E02_09800	COG1876	peptidase activity
M5E02_09805	COG0813	purine-nucleoside phosphorylase activity
M5E02_09815	COG0671	phosphoesterase, PA-phosphatase related
M5E02_09835	COG4479	Belongs to the UPF0346 family
M5E02_09845	COG1509	lysine 2,3-aminomutase activity
M5E02_09850	COG3829	transcription factor binding
M5E02_09855	COG0463	Glycosyl transferase, family 2
M5E02_09870	COG4641	Protein conserved in bacteria
M5E02_09880	COG1086	Polysaccharide biosynthesis protein
M5E02_09885	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E02_09890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
M5E02_09895	COG1846	Transcriptional regulator
M5E02_09915	COG4698	Protein conserved in bacteria
M5E02_09920	COG2755	lipolytic protein G-D-S-L family
M5E02_09925	COG1999	signal sequence binding
M5E02_09940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M5E02_09945	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
M5E02_09950	COG1272	protein, Hemolysin III
M5E02_09955	COG0204	Acyl-transferase
M5E02_09960	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
M5E02_09965	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
M5E02_09970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E02_09980	COG2136	Putative SAM-dependent methyltransferase
M5E02_09980	COG2521	methyltransferase
M5E02_09990	COG0129	dihydroxy-acid dehydratase activity
M5E02_09995	COG1413	lyase activity
M5E02_10000	COG1418	mRNA catabolic process
M5E02_10005	COG0386	Belongs to the glutathione peroxidase family
M5E02_10010	COG2759	Belongs to the formate--tetrahydrofolate ligase family
M5E02_10015	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
M5E02_10020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M5E02_10030	COG1278	Cold shock
M5E02_10045	COG0328	RNA-DNA hybrid ribonuclease activity
M5E02_10055	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_10060	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
M5E02_10065	COG0328	RNA-DNA hybrid ribonuclease activity
M5E02_10075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E02_10085	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5E02_10090	COG1755	Isoprenylcysteine carboxyl methyltransferase
M5E02_10095	COG3424	synthase
M5E02_10110	COG0726	polysaccharide deacetylase
M5E02_10115	COG2233	PERMEase
M5E02_10120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E02_10125	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
M5E02_10130	COG1199	ATP-dependent helicase activity
M5E02_10140	COG0116	Belongs to the methyltransferase superfamily
M5E02_10150	COG3599	regulation of cell shape
M5E02_10155	COG4474	Belongs to the UPF0398 family
M5E02_10165	COG3359	exonuclease
M5E02_10170	COG1205	dead DEAH box helicase
M5E02_10170	COG1111	helicase
M5E02_10175	COG1902	pentaerythritol trinitrate reductase activity
M5E02_10180	COG2190	(PTS) system
M5E02_10185	COG0071	Belongs to the small heat shock protein (HSP20) family
M5E02_10215	COG3331	DNA recombination
M5E02_10220	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E02_10220	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5E02_10230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M5E02_10235	COG3935	DnaD domain protein
M5E02_10240	COG0017	Asparaginyl-tRNA synthetase
M5E02_10245	COG5353	protein conserved in bacteria
M5E02_10255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M5E02_10255	COG1199	ATP-dependent helicase activity
M5E02_10260	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
M5E02_10265	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
M5E02_10270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
M5E02_10280	COG0617	tRNA 3'-terminal CCA addition
M5E02_10285	COG0438	transferase activity, transferring glycosyl groups
M5E02_10290	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
M5E02_10295	COG1803	Methylglyoxal synthase
M5E02_10300	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M5E02_10305	COG1694	Mazg nucleotide pyrophosphohydrolase
M5E02_10310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E02_10320	COG4347	Protein of unknown function (DUF1405)
M5E02_10325	COG2010	Cytochrome c
M5E02_10325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5E02_10330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M5E02_10335	COG0723	plastoquinol--plastocyanin reductase activity
M5E02_10345	COG5582	Belongs to the UPF0302 family
M5E02_10350	COG0457	Tetratricopeptide repeat
M5E02_10355	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
M5E02_10360	COG0287	Prephenate dehydrogenase
M5E02_10365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
M5E02_10370	COG0159	tryptophan synthase activity
M5E02_10375	COG0133	tryptophan synthase activity
M5E02_10380	COG0135	phosphoribosylanthranilate isomerase activity
M5E02_10385	COG0134	indole-3-glycerol-phosphate synthase activity
M5E02_10400	COG4401	Chorismate mutase type I
M5E02_10405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
M5E02_10410	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
M5E02_10415	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
M5E02_10420	COG0105	UTP biosynthetic process
M5E02_10425	COG0142	geranyltranstransferase activity
M5E02_10430	COG2226	methyltransferase
M5E02_10435	COG0142	geranyltranstransferase activity
M5E02_10445	COG0302	gtp cyclohydrolase
M5E02_10450	COG0776	regulation of translation
M5E02_10455	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
M5E02_10470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M5E02_10475	COG1160	GTP binding
M5E02_10500	COG1304	FMN binding
M5E02_10505	COG0539	negative regulation of cytoplasmic translation
M5E02_10510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M5E02_10520	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
M5E02_10525	COG2959	enzyme of heme biosynthesis
M5E02_10530	COG3773	Cell wall hydrolase
M5E02_10530	COG3409	Peptidoglycan-binding domain 1 protein
M5E02_10535	COG2339	peptidase activity
M5E02_10540	COG0492	ferredoxin-NADP+ reductase activity
M5E02_10545	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E02_10550	COG4862	establishment of competence for transformation
M5E02_10555	COG1408	metallophosphoesterase
M5E02_10565	COG1388	LysM domain
M5E02_10570	COG1266	CAAX protease self-immunity
M5E02_10575	COG0514	ATP-dependent DNA helicase (RecQ)
M5E02_10580	COG4955	Helix-turn-helix domain
M5E02_10585	COG1141	Ferredoxin
M5E02_10590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
M5E02_10595	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
M5E02_10600	COG0791	NLP P60 protein
M5E02_10600	COG1388	LysM domain
M5E02_10610	COG1595	DNA-templated transcription, initiation
M5E02_10615	COG5002	protein histidine kinase activity
M5E02_10620	COG0745	RESPONSE REGULATOR receiver
M5E02_10625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5E02_10630	COG1333	cytochrome c biogenesis protein
M5E02_10635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_10640	COG1187	pseudouridine synthase activity
M5E02_10645	COG0700	Nucleoside recognition
M5E02_10650	COG2715	membrane protein required for spore maturation
M5E02_10655	COG1686	Belongs to the peptidase S11 family
M5E02_10665	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
M5E02_10670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
M5E02_10680	COG1547	Domain of unknown function (DUF309)
M5E02_10685	COG0456	acetyltransferase
M5E02_10690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
M5E02_10700	COG0307	riboflavin synthase, alpha
M5E02_10720	COG2814	Major facilitator Superfamily
M5E02_10725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
M5E02_10730	COG4086	secreted protein
M5E02_10735	COG0019	diaminopimelate decarboxylase activity
M5E02_10740	COG0697	spore germination
M5E02_10755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M5E02_10775	COG1191	sigma factor activity
M5E02_10780	COG2172	sigma factor antagonist activity
M5E02_10790	COG1686	Belongs to the peptidase S11 family
M5E02_10795	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
M5E02_10800	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
M5E02_10805	COG4974	Belongs to the 'phage' integrase family
M5E02_10815	COG0735	belongs to the Fur family
M5E02_10820	COG1300	Membrane
M5E02_10825	COG1404	Belongs to the peptidase S8 family
M5E02_10835	COG2153	protein acetylation
M5E02_10840	COG1379	DNA repair
M5E02_10845	COG0494	nUDIX hydrolase
M5E02_10850	COG0667	Aldo Keto reductase
M5E02_10860	COG1073	alpha beta
M5E02_10865	COG0457	Tetratricopeptide repeat
M5E02_10875	COG4918	Iron-sulphur cluster biosynthesis
M5E02_10880	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
M5E02_10880	COG0456	acetyltransferase
M5E02_10885	COG0456	acetyltransferase
M5E02_10895	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E02_10905	COG2211	Major facilitator Superfamily
M5E02_10910	COG1072	(Pantothenic acid kinase))
M5E02_10915	COG0446	pyridine nucleotide-disulphide oxidoreductase
M5E02_10920	COG0300	oxidoreductase activity
M5E02_10925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E02_10930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E02_10950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E02_10955	COG4187	Peptidase family M20/M25/M40
M5E02_10960	COG1902	pentaerythritol trinitrate reductase activity
M5E02_10965	COG0596	Alpha beta hydrolase
M5E02_10970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
M5E02_10980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
M5E02_10985	COG2188	Transcriptional regulator
M5E02_10990	COG2723	6-phospho-beta-galactosidase activity
M5E02_10995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E02_11000	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E02_11005	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E02_11010	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_11020	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
M5E02_11025	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
M5E02_11040	COG0706	membrane insertase activity
M5E02_11050	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5E02_11055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M5E02_11060	COG0346	lactoylglutathione lyase activity
M5E02_11070	COG1376	ErfK ybiS ycfS ynhG family protein
M5E02_11075	COG4129	membrane
M5E02_11080	COG1126	abc transporter atp-binding protein
M5E02_11085	COG0765	amino acid transport
M5E02_11090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_11100	COG1597	lipid kinase activity
M5E02_11110	COG0508	dehydrogenase complex catalyzes the overall conversion of
M5E02_11115	COG0022	dehydrogenase e1 component
M5E02_11120	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M5E02_11125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M5E02_11130	COG3426	butyrate kinase activity
M5E02_11135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E02_11140	COG0280	phosphate acetyltransferase
M5E02_11145	COG3290	protein histidine kinase activity
M5E02_11145	COG3829	transcription factor binding
M5E02_11155	COG0584	glycerophosphoryl diester phosphodiesterase
M5E02_11160	COG0457	Tetratricopeptide repeat
M5E02_11165	COG0745	RESPONSE REGULATOR receiver
M5E02_11170	COG0750	zinc metalloprotease
M5E02_11175	COG0497	DNA recombination
M5E02_11180	COG1438	arginine binding
M5E02_11185	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
M5E02_11190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
M5E02_11195	COG0142	geranyltranstransferase activity
M5E02_11200	COG1722	exodeoxyribonuclease VII activity
M5E02_11205	COG1570	exodeoxyribonuclease VII activity
M5E02_11210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M5E02_11215	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M5E02_11220	COG1302	Protein conserved in bacteria
M5E02_11225	COG0439	Biotin carboxylase
M5E02_11230	COG0511	ligase activity, forming carbon-carbon bonds
M5E02_11270	COG3854	ATPases associated with a variety of cellular activities
M5E02_11280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M5E02_11285	COG0006	proline dipeptidase activity
M5E02_11290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
M5E02_11300	COG3872	metal-dependent enzyme
M5E02_11310	COG1752	Esterase of the alpha-beta hydrolase superfamily
M5E02_11315	COG1321	iron dependent repressor
M5E02_11320	COG0095	Lipoate-protein ligase
M5E02_11325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E02_11330	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5E02_11335	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
M5E02_11340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
M5E02_11350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5E02_11375	COG0681	Belongs to the peptidase S26 family
M5E02_11410	COG4970	Tfp pilus assembly protein FimT
M5E02_11415	COG4537	Required for transformation and DNA binding
M5E02_11420	COG1459	type II secretion system
M5E02_11425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
M5E02_11430	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_11440	COG1393	Belongs to the ArsC family
M5E02_11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E02_11460	COG0011	TIGRFAM Protein of
M5E02_11465	COG2814	Major facilitator Superfamily
M5E02_11470	COG2866	Carboxypeptidase
M5E02_11475	COG1368	sulfuric ester hydrolase activity
M5E02_11480	COG1940	carbohydrate kinase activity
M5E02_11485	COG4483	Protein conserved in bacteria
M5E02_11490	COG0457	Tetratricopeptide repeat
M5E02_11490	COG0705	Rhomboid family
M5E02_11510	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M5E02_11515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E02_11525	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E02_11530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E02_11535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
M5E02_11540	COG0581	inorganic phosphate transmembrane transporter activity
M5E02_11545	COG0573	inorganic phosphate transmembrane transporter activity
M5E02_11550	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
M5E02_11555	COG0768	penicillin binding
M5E02_11560	COG0477	Major facilitator Superfamily
M5E02_11565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M5E02_11570	COG2839	Protein conserved in bacteria
M5E02_11575	COG5521	maltodextrose utilization protein MalA
M5E02_11580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
M5E02_11585	COG1388	LysM domain
M5E02_11590	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
M5E02_11595	COG4709	membrane
M5E02_11600	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
M5E02_11605	COG1940	carbohydrate kinase activity
M5E02_11610	COG0735	belongs to the Fur family
M5E02_11615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E02_11620	COG1121	(ABC) transporter
M5E02_11625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E02_11635	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
M5E02_11640	COG0513	Belongs to the DEAD box helicase family
M5E02_11650	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
M5E02_11655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
M5E02_11660	COG2384	SAM-dependent methyltransferase
M5E02_11665	COG2010	Cytochrome c
M5E02_11670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M5E02_11675	COG0358	DNA primase activity
M5E02_11680	COG1671	Belongs to the UPF0178 family
M5E02_11685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M5E02_11690	COG0517	IMP dehydrogenase activity
M5E02_11695	COG0751	glycine-tRNA ligase activity
M5E02_11700	COG0752	glycyl-tRNA synthetase alpha subunit
M5E02_11705	COG1381	Involved in DNA repair and RecF pathway recombination
M5E02_11715	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M5E02_11720	COG0295	cytidine deaminase activity
M5E02_11725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
M5E02_11730	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M5E02_11735	COG1480	7TM receptor with intracellular HD hydrolase
M5E02_11740	COG1702	phosphate starvation-inducible protein PhoH
M5E02_11745	COG0561	phosphatase activity
M5E02_11760	COG4864	UPF0365 protein
M5E02_11765	COG1030	water channel activity
M5E02_11770	COG1610	YqeY-like protein
M5E02_11780	COG1283	sodium-dependent phosphate transmembrane transporter activity
M5E02_11785	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M5E02_11790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M5E02_11795	COG2264	protein methyltransferase activity
M5E02_11800	COG0484	heat shock protein binding
M5E02_11805	COG0443	Heat shock 70 kDa protein
M5E02_11810	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M5E02_11815	COG1420	regulation of RNA biosynthetic process
M5E02_11820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M5E02_11825	COG0481	GTPase activity
M5E02_11835	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E02_11840	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
M5E02_11845	COG0268	Binds directly to 16S ribosomal RNA
M5E02_11850	COG1466	dna polymerase III delta subunit
M5E02_11860	COG0658	competence protein
M5E02_11860	COG2333	competence protein COMEC
M5E02_11865	COG2131	deaminase
M5E02_11870	COG1555	photosystem II stabilization
M5E02_11875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
M5E02_11880	COG2226	methyltransferase
M5E02_11885	COG0799	negative regulation of ribosome biogenesis
M5E02_11890	COG1713	HD superfamily hydrolase involved in NAD metabolism
M5E02_11895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
M5E02_11900	COG1534	Rna-binding protein
M5E02_11905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
M5E02_11910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
M5E02_11915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
M5E02_11930	COG2755	lipolytic protein G-D-S-L family
M5E02_11940	COG0457	Tetratricopeptide repeat
M5E02_11980	COG0726	polysaccharide deacetylase
M5E02_12010	COG2160	L-arabinose isomerase activity
M5E02_12025	COG1609	Transcriptional regulator
M5E02_12035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M5E02_12040	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
M5E02_12045	COG1733	regulation of RNA biosynthetic process
M5E02_12050	COG0657	acetylesterase activity
M5E02_12065	COG2602	Beta-lactamase
M5E02_12070	COG1960	acyl-CoA dehydrogenase activity
M5E02_12075	COG1126	abc transporter atp-binding protein
M5E02_12080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_12085	COG0765	amino acid transport
M5E02_12095	COG3546	catalase activity
M5E02_12100	COG1063	alcohol dehydrogenase
M5E02_12110	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_12115	COG0842	Transport permease protein
M5E02_12120	COG0842	Transport permease protein
M5E02_12120	COG1511	domain protein
M5E02_12125	COG1131	(ABC) transporter
M5E02_12130	COG2226	methyltransferase
M5E02_12135	COG1063	alcohol dehydrogenase
M5E02_12140	COG2226	methyltransferase
M5E02_12165	COG0626	cystathionine gamma-synthase activity
M5E02_12170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E02_12175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
M5E02_12180	COG2226	methyltransferase
M5E02_12195	COG0768	penicillin binding
M5E02_12200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M5E02_12210	COG0572	uridine kinase
M5E02_12215	COG0826	peptidase U32
M5E02_12220	COG0826	peptidase U32
M5E02_12225	COG4122	O-methyltransferase activity
M5E02_12230	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M5E02_12235	COG0183	Belongs to the thiolase family
M5E02_12240	COG0318	PFAM AMP-dependent synthetase and ligase
M5E02_12245	COG1268	BioY protein
M5E02_12250	COG3906	Belongs to the UPF0473 family
M5E02_12255	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M5E02_12260	COG4472	Bacterial protein of unknown function (DUF965)
M5E02_12265	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M5E02_12270	COG0628	permease
M5E02_12275	COG1126	abc transporter atp-binding protein
M5E02_12280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_12285	COG0765	amino acid transport
M5E02_12290	COG0765	amino acid transport
M5E02_12305	COG3881	PFAM PRC-barrel domain
M5E02_12310	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
M5E02_12315	COG0457	Tetratricopeptide repeat
M5E02_12320	COG0482	sulfurtransferase activity
M5E02_12325	COG1104	cysteine desulfurase activity
M5E02_12330	COG1959	2 iron, 2 sulfur cluster binding
M5E02_12335	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
M5E02_12340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
M5E02_12355	COG0124	histidyl-tRNA synthetase
M5E02_12365	COG3103	Sh3 type 3 domain protein
M5E02_12365	COG4991	sh3 domain protein
M5E02_12365	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E02_12370	COG1490	D-aminoacyl-tRNA deacylase activity
M5E02_12375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M5E02_12380	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
M5E02_12385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
M5E02_12385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
M5E02_12390	COG5416	Lipopolysaccharide assembly protein A domain
M5E02_12395	COG0490	domain, Protein
M5E02_12400	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5E02_12400	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M5E02_12410	COG2244	polysaccharide biosynthetic process
M5E02_12415	COG2323	membrane
M5E02_12425	COG1862	Preprotein translocase
M5E02_12430	COG0343	queuine tRNA-ribosyltransferase activity
M5E02_12435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M5E02_12445	COG2255	four-way junction helicase activity
M5E02_12450	COG0632	four-way junction helicase activity
M5E02_12460	COG2112	serine threonine protein kinase
M5E02_12475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
M5E02_12490	COG1388	LysM domain
M5E02_12490	COG1388	LysM domain
M5E02_12495	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
M5E02_12500	COG0157	Belongs to the NadC ModD family
M5E02_12505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
M5E02_12510	COG1104	cysteine desulfurase activity
M5E02_12515	COG1827	regulation of RNA biosynthetic process
M5E02_12520	COG0077	Prephenate dehydratase
M5E02_12525	COG4492	Belongs to the UPF0735 family
M5E02_12530	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M5E02_12535	COG3290	protein histidine kinase activity
M5E02_12540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M5E02_12545	COG2868	ribosomal protein
M5E02_12550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M5E02_12555	COG1994	Peptidase M50
M5E02_12560	COG0739	heme binding
M5E02_12565	COG2894	cell division
M5E02_12570	COG0850	regulation of cytokinetic process
M5E02_12575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
M5E02_12585	COG1077	Cell shape determining protein MreB Mrl
M5E02_12590	COG2003	Belongs to the UPF0758 family
M5E02_12595	COG0424	maF-like protein
M5E02_12610	COG0285	dihydrofolate synthase activity
M5E02_12615	COG0525	valine-tRNA ligase activity
M5E02_12625	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E02_12630	COG1388	LysM domain
M5E02_12635	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
M5E02_12640	COG0113	porphobilinogen synthase activity
M5E02_12645	COG1587	Uroporphyrinogen-III synthase
M5E02_12650	COG0181	hydroxymethylbilane synthase activity
M5E02_12655	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M5E02_12660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
M5E02_12670	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M5E02_12675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M5E02_12680	COG0470	DNA polymerase III
M5E02_12680	COG1067	ATP-dependent peptidase activity
M5E02_12685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M5E02_12690	COG0544	peptidyl-prolyl cis-trans isomerase activity
M5E02_12695	COG0457	Tetratricopeptide repeat
M5E02_12695	COG1477	protein flavinylation
M5E02_12700	COG0066	3-isopropylmalate dehydratase activity
M5E02_12705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
M5E02_12710	COG0473	3-isopropylmalate dehydrogenase activity
M5E02_12715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
M5E02_12720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
M5E02_12725	COG0440	acetolactate synthase activity
M5E02_12730	COG0028	Belongs to the TPP enzyme family
M5E02_12735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E02_12740	COG2706	6-phosphogluconolactonase activity
M5E02_12745	COG3339	Conserved Protein
M5E02_12750	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
M5E02_12755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M5E02_12760	COG1696	Membrane protein involved in D-alanine export
M5E02_12840	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_12855	COG0622	Phosphoesterase
M5E02_12860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
M5E02_12865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M5E02_12870	COG5401	PFAM Sporulation and spore germination
M5E02_12875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
M5E02_12880	COG1846	Transcriptional regulator
M5E02_12885	COG2197	response regulator
M5E02_12890	COG2851	Citrate transporter
M5E02_12895	COG0583	DNA-binding transcription factor activity
M5E02_12900	COG2828	Protein conserved in bacteria
M5E02_12910	COG0824	Thioesterase
M5E02_12915	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M5E02_12920	COG1053	succinate dehydrogenase
M5E02_12925	COG2009	succinate dehydrogenase
M5E02_12930	COG1719	4-vinyl reductase, 4VR
M5E02_12940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E02_12945	COG0601	transmembrane transport
M5E02_12955	COG0527	aspartate kinase activity
M5E02_12960	COG0322	excinuclease ABC activity
M5E02_12965	COG3118	belongs to the thioredoxin family
M5E02_12970	COG3534	alpha-L-arabinofuranosidase
M5E02_12975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
M5E02_12980	COG2086	electron transfer activity
M5E02_12985	COG1024	Enoyl-CoA hydratase
M5E02_12990	COG1309	transcriptional regulator
M5E02_12995	COG0318	PFAM AMP-dependent synthetase and ligase
M5E02_13005	COG3766	membrane
M5E02_13010	COG1193	negative regulation of DNA recombination
M5E02_13015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E02_13015	COG1796	DNA polymerase
M5E02_13020	COG1286	toxin biosynthetic process
M5E02_13025	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M5E02_13030	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M5E02_13035	COG0072	phenylalanine-tRNA ligase activity
M5E02_13035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E02_13040	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M5E02_13045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M5E02_13055	COG1966	Carbon starvation protein
M5E02_13060	COG1363	Peptidase, m42
M5E02_13070	COG3326	Membrane
M5E02_13075	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M5E02_13080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M5E02_13085	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M5E02_13090	COG1346	cytolysis
M5E02_13100	COG3279	Response regulator of the LytR AlgR family
M5E02_13105	COG3275	phosphorelay sensor kinase activity
M5E02_13110	COG1011	Hydrolase
M5E02_13120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M5E02_13130	COG0398	Pfam SNARE associated Golgi protein
M5E02_13135	COG1484	DNA-dependent DNA replication
M5E02_13140	COG3611	Membrane attachment protein
M5E02_13145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
M5E02_13155	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
M5E02_13160	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E02_13165	COG0237	dephospho-CoA kinase activity
M5E02_13170	COG1971	Probably functions as a manganese efflux pump
M5E02_13175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
M5E02_13180	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E02_13180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M5E02_13185	COG5002	protein histidine kinase activity
M5E02_13190	COG0745	RESPONSE REGULATOR receiver
M5E02_13195	COG0039	L-malate dehydrogenase activity
M5E02_13200	COG0538	isocitrate dehydrogenase activity
M5E02_13205	COG0372	Belongs to the citrate synthase family
M5E02_13210	COG2707	UPF0756 membrane protein
M5E02_13215	COG0628	permease
M5E02_13220	COG3030	protein affecting phage T7 exclusion by the F plasmid
M5E02_13230	COG0205	6-phosphofructokinase activity
M5E02_13235	COG0825	malonyl-CoA metabolic process
M5E02_13240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
M5E02_13245	COG0281	malic enzyme
M5E02_13250	COG0587	DNA-directed DNA polymerase activity
M5E02_13270	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
M5E02_13280	COG4109	DRTGG domain
M5E02_13285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
M5E02_13290	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_13295	COG0165	Argininosuccinate lyase
M5E02_13300	COG0137	argininosuccinate synthase activity
M5E02_13305	COG0521	Mo-molybdopterin cofactor biosynthetic process
M5E02_13310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M5E02_13315	COG0827	DNA restriction-modification system
M5E02_13320	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
M5E02_13325	COG3874	Sporulation protein YtfJ
M5E02_13335	COG1714	RDD family
M5E02_13340	COG0616	signal peptide processing
M5E02_13345	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M5E02_13355	COG3239	Fatty acid desaturase
M5E02_13360	COG4585	Histidine kinase
M5E02_13365	COG2197	response regulator
M5E02_13370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_13375	COG0745	RESPONSE REGULATOR receiver
M5E02_13380	COG0642	Histidine kinase
M5E02_13385	COG0772	Belongs to the SEDS family
M5E02_13390	COG1695	Transcriptional regulator
M5E02_13395	COG1136	(ABC) transporter
M5E02_13400	COG0577	efflux transmembrane transporter activity
M5E02_13405	COG0402	S-adenosylhomocysteine deaminase activity
M5E02_13410	COG2249	NAD(P)H dehydrogenase (quinone) activity
M5E02_13420	COG1279	arginine transmembrane transporter activity
M5E02_13425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E02_13435	COG0301	tRNA thio-modification
M5E02_13440	COG1104	cysteine desulfurase activity
M5E02_13445	COG1114	Component of the transport system for branched-chain amino acids
M5E02_13450	COG1114	Component of the transport system for branched-chain amino acids
M5E02_13455	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
M5E02_13460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
M5E02_13465	COG1309	transcriptional regulator
M5E02_13470	COG1956	GAF domain-containing protein
M5E02_13475	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M5E02_13490	COG1335	isochorismatase
M5E02_13495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
M5E02_13500	COG2329	Antibiotic biosynthesis monooxygenase
M5E02_13505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M5E02_13510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
M5E02_13515	COG0454	-acetyltransferase
M5E02_13520	COG0517	IMP dehydrogenase activity
M5E02_13525	COG0123	including yeast histone deacetylase and acetoin utilization protein
M5E02_13530	COG1609	Transcriptional regulator
M5E02_13535	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
M5E02_13535	COG1605	Chorismate mutase
M5E02_13540	COG3118	belongs to the thioredoxin family
M5E02_13545	COG4980	gas vesicle protein
M5E02_13550	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
M5E02_13555	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M5E02_13560	COG1674	ftsk spoiiie
M5E02_13565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M5E02_13570	COG4848	Belongs to the UPF0354 family
M5E02_13575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_13590	COG1363	Peptidase, m42
M5E02_13595	COG5584	Small secreted protein
M5E02_13600	COG0281	malic enzyme
M5E02_13605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
M5E02_13610	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M5E02_13620	COG0510	thiamine kinase activity
M5E02_13630	COG1597	lipid kinase activity
M5E02_13640	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
M5E02_13645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
M5E02_13650	COG3340	Belongs to the peptidase S51 family
M5E02_13655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M5E02_13660	COG2252	PERMEase
M5E02_13665	COG1349	DNA-binding transcription factor activity
M5E02_13670	COG1187	pseudouridine synthase activity
M5E02_13675	COG2244	polysaccharide biosynthetic process
M5E02_13680	COG2081	HI0933 family
M5E02_13690	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
M5E02_13695	COG3196	Protein conserved in bacteria
M5E02_13705	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M5E02_13710	COG5578	integral membrane protein
M5E02_13715	COG0673	inositol 2-dehydrogenase activity
M5E02_13720	COG1653	transport
M5E02_13725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
M5E02_13730	COG4209	transmembrane transport
M5E02_13735	COG2207	Transcriptional regulator
M5E02_13740	COG1733	regulation of RNA biosynthetic process
M5E02_13745	COG2814	Major facilitator Superfamily
M5E02_13750	COG0656	L-ascorbic acid biosynthetic process
M5E02_13755	COG1653	transport
M5E02_13760	COG0395	ABC-type sugar transport system, permease component
M5E02_13765	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E02_13770	COG1073	alpha beta
M5E02_13775	COG0495	leucyl-tRNA aminoacylation
M5E02_13785	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_13785	COG2202	Pas domain
M5E02_13790	COG2433	Pfam Transposase IS66
M5E02_13795	COG0577	efflux transmembrane transporter activity
M5E02_13800	COG1136	(ABC) transporter
M5E02_13810	COG1131	(ABC) transporter
M5E02_13815	COG1725	Transcriptional regulator
M5E02_13830	COG1242	4 iron, 4 sulfur cluster binding
M5E02_13835	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
M5E02_13845	COG2267	carboxylic ester hydrolase activity
M5E02_13850	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M5E02_13855	COG0367	asparagine synthase
M5E02_13860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
M5E02_13865	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
M5E02_13875	COG1506	peptidase
M5E02_13880	COG1233	COG1233 Phytoene dehydrogenase and related
M5E02_13900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
M5E02_13905	COG1116	anion transmembrane transporter activity
M5E02_13910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
M5E02_13915	COG0494	nUDIX hydrolase
M5E02_13920	COG2310	stress, protein
M5E02_13935	COG4824	toxin secretion phage lysis holin
M5E02_13945	COG0783	Belongs to the Dps family
M5E02_13960	COG1854	S-ribosylhomocysteine lyase activity
M5E02_13965	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M5E02_13970	COG0288	reversible hydration of carbon dioxide
M5E02_13975	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5E02_13975	COG3443	Belongs to the bacterial solute-binding protein 9 family
M5E02_13980	COG0254	rRNA binding
M5E02_13985	COG1271	oxidase subunit
M5E02_13990	COG1294	oxidase, subunit
M5E02_14005	COG4948	Mandelate Racemase Muconate Lactonizing
M5E02_14010	COG0318	PFAM AMP-dependent synthetase and ligase
M5E02_14015	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
M5E02_14020	COG0596	Alpha beta hydrolase
M5E02_14025	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
M5E02_14030	COG1169	isochorismate synthase
M5E02_14035	COG1575	Belongs to the MenA family. Type 1 subfamily
M5E02_14040	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
M5E02_14170	COG3859	Proton-coupled thiamine transporter YuaJ
M5E02_14175	COG1247	-acetyltransferase
M5E02_14180	COG3339	Conserved Protein
M5E02_14185	COG0772	Belongs to the SEDS family
M5E02_14190	COG0772	Belongs to the SEDS family
M5E02_14195	COG2268	Band 7 protein
M5E02_14200	COG1585	Membrane protein implicated in regulation of membrane protease activity
M5E02_14205	COG2318	DinB family
M5E02_14210	COG1454	alcohol dehydrogenase
M5E02_14215	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_14220	COG1510	regulation of RNA biosynthetic process
M5E02_14230	COG0457	Tetratricopeptide repeat
M5E02_14250	COG3409	Peptidoglycan-binding domain 1 protein
M5E02_14250	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E02_14285	COG3778	Protein conserved in bacteria
M5E02_14290	COG3299	homolog of phage Mu protein gp47
M5E02_14295	COG3628	GPW Gp25 family protein
M5E02_14305	COG4193	domain, Protein
M5E02_14310	COG1652	LysM domain
M5E02_14315	COG5280	Phage tail tape measure protein TP901
M5E02_14315	COG3953	SLT domain
M5E02_14315	COG5280	Phage tail tape measure protein TP901
M5E02_14315	COG3953	SLT domain
M5E02_14370	COG4653	Phage capsid family
M5E02_14375	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5E02_14380	COG2369	cell adhesion
M5E02_14385	COG5518	Phage portal protein
M5E02_14390	COG1783	phage Terminase large subunit
M5E02_14425	COG4282	regulation of fungal-type cell wall biogenesis
M5E02_14525	COG0305	Participates in initiation and elongation during chromosome replication
M5E02_14590	COG1396	sequence-specific DNA binding
M5E02_14600	COG2856	Zn peptidase
M5E02_14605	COG0582	viral genome integration into host DNA
M5E02_14615	COG5632	N-Acetylmuramoyl-L-alanine amidase
M5E02_14615	COG3409	Peptidoglycan-binding domain 1 protein
M5E02_14670	COG3778	Protein conserved in bacteria
M5E02_14675	COG3299	homolog of phage Mu protein gp47
M5E02_14680	COG3628	GPW Gp25 family protein
M5E02_14690	COG4193	domain, Protein
M5E02_14695	COG1652	LysM domain
M5E02_14700	COG5280	Phage tail tape measure protein TP901
M5E02_14700	COG3953	SLT domain
M5E02_14700	COG5280	Phage tail tape measure protein TP901
M5E02_14700	COG3953	SLT domain
M5E02_14750	COG4653	Phage capsid family
M5E02_14755	COG0338	D12 class N6 adenine-specific DNA methyltransferase
M5E02_14760	COG5518	Phage portal protein
M5E02_14765	COG1783	phage Terminase large subunit
M5E02_14770	COG5484	DNA packaging
M5E02_14775	COG1595	DNA-templated transcription, initiation
M5E02_14785	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
M5E02_14805	COG1396	sequence-specific DNA binding
M5E02_14815	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
M5E02_14830	COG0628	permease
M5E02_14840	COG0673	inositol 2-dehydrogenase activity
M5E02_14845	COG0693	protein deglycase activity
M5E02_14850	COG0840	transmembrane signaling receptor activity
M5E02_14855	COG0840	transmembrane signaling receptor activity
M5E02_14860	COG0840	transmembrane signaling receptor activity
M5E02_14865	COG0840	transmembrane signaling receptor activity
M5E02_14880	COG2070	2-Nitropropane dioxygenase
M5E02_14885	COG0432	Pfam Uncharacterised protein family UPF0047
M5E02_14890	COG1253	flavin adenine dinucleotide binding
M5E02_14895	COG2738	Putative neutral zinc metallopeptidase
M5E02_14905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
M5E02_14920	COG0166	Belongs to the GPI family
M5E02_14925	COG1979	alcohol dehydrogenase
M5E02_14930	COG1979	alcohol dehydrogenase
M5E02_14935	COG2155	Conserved Protein
M5E02_14940	COG1098	S1 RNA binding domain
M5E02_14945	COG0436	Aminotransferase
M5E02_14950	COG1522	sequence-specific DNA binding
M5E02_14955	COG2267	carboxylic ester hydrolase activity
M5E02_14965	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
M5E02_14970	COG2205	protein histidine kinase activity
M5E02_14985	COG5018	Exonuclease
M5E02_14990	COG2814	Major facilitator Superfamily
M5E02_14995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E02_15000	COG3011	Protein conserved in bacteria
M5E02_15010	COG3290	protein histidine kinase activity
M5E02_15015	COG4565	transcriptional regulatory protein
M5E02_15020	COG1744	ABC transporter substrate-binding protein PnrA-like
M5E02_15025	COG3845	ABC transporter
M5E02_15030	COG4603	Belongs to the binding-protein-dependent transport system permease family
M5E02_15035	COG1079	Belongs to the binding-protein-dependent transport system permease family
M5E02_15040	COG3493	citrate carrier protein
M5E02_15050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M5E02_15050	COG2111	Na H antiporter
M5E02_15055	COG2111	Na H antiporter
M5E02_15060	COG1006	Multisubunit Na H antiporter MnhC subunit
M5E02_15065	COG0651	ATP synthesis coupled electron transport
M5E02_15070	COG1863	multisubunit Na H antiporter MnhE subunit
M5E02_15075	COG2212	antiporter activity
M5E02_15080	COG1320	monovalent cation:proton antiporter activity
M5E02_15085	COG2050	protein possibly involved in aromatic compounds catabolism
M5E02_15090	COG2197	response regulator
M5E02_15095	COG4585	Histidine kinase
M5E02_15105	COG0142	geranyltranstransferase activity
M5E02_15120	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
M5E02_15125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
M5E02_15130	COG1335	isochorismatase
M5E02_15135	COG5506	Protein of unknown function (DUF1694)
M5E02_15155	COG0628	permease
M5E02_15170	COG1418	mRNA catabolic process
M5E02_15175	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_15185	COG1511	domain protein
M5E02_15190	COG0433	COG0433 Predicted ATPase
M5E02_15190	COG1674	ftsk spoiiie
M5E02_15195	COG4499	WXG100 protein secretion system (Wss), protein YukC
M5E02_15200	COG5417	Belongs to the EsaB family
M5E02_15205	COG4842	Belongs to the WXG100 family
M5E02_15210	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
M5E02_15210	COG2508	Transcriptional regulator
M5E02_15215	COG0686	Belongs to the AlaDH PNT family
M5E02_15220	COG1268	BioY protein
M5E02_15225	COG4326	sporulation control protein
M5E02_15230	COG2056	Na+-H+ antiporter family
M5E02_15235	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M5E02_15240	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
M5E02_15245	COG3584	3D domain protein
M5E02_15260	COG1252	NADH dehydrogenase
M5E02_15265	COG0492	ferredoxin-NADP+ reductase activity
M5E02_15275	COG0789	Transcriptional regulator
M5E02_15280	COG5504	Zn-dependent protease
M5E02_15305	COG0316	Belongs to the HesB IscA family
M5E02_15310	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M5E02_15315	COG4844	belongs to the
M5E02_15320	COG1252	NADH dehydrogenase
M5E02_15330	COG4837	Protein of unknown function (DUF1462)
M5E02_15340	COG0823	Involved in the tonB-independent uptake of proteins
M5E02_15340	COG1506	peptidase
M5E02_15340	COG4946	Tricorn protease homolog
M5E02_15345	COG0083	homoserine kinase activity
M5E02_15350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
M5E02_15355	COG0460	homoserine dehydrogenase
M5E02_15360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E02_15365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
M5E02_15370	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M5E02_15375	COG0647	UMP catabolic process
M5E02_15380	COG2445	Protein of unknown function DUF86
M5E02_15385	COG4470	Protein conserved in bacteria
M5E02_15395	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M5E02_15400	COG0739	heme binding
M5E02_15415	COG3377	Domain of unknown function (DUF1805)
M5E02_15420	COG0737	Belongs to the 5'-nucleotidase family
M5E02_15425	COG1801	Protein of unknown function DUF72
M5E02_15430	COG2508	Transcriptional regulator
M5E02_15435	COG2140	Oxalate decarboxylase
M5E02_15445	COG2814	Major facilitator Superfamily
M5E02_15450	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
M5E02_15455	COG2356	endonuclease I
M5E02_15470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_15475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_15480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_15500	COG0642	Histidine kinase
M5E02_15500	COG5002	protein histidine kinase activity
M5E02_15505	COG0745	RESPONSE REGULATOR receiver
M5E02_15510	COG2311	Membrane
M5E02_15520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
M5E02_15530	COG1309	transcriptional regulator
M5E02_15535	COG0719	Fe-S assembly protein
M5E02_15540	COG0822	iron-sulfur transferase activity
M5E02_15545	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
M5E02_15550	COG0719	Fe-S assembly protein
M5E02_15555	COG0396	ATPase activity
M5E02_15565	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
M5E02_15570	COG1464	Belongs to the NlpA lipoprotein family
M5E02_15575	COG2011	ABC-type metal ion transport system permease component
M5E02_15580	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
M5E02_15590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_15595	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
M5E02_15605	COG0509	glycine decarboxylation via glycine cleavage system
M5E02_15610	COG1393	Belongs to the ArsC family
M5E02_15615	COG1960	acyl-CoA dehydrogenase activity
M5E02_15620	COG0183	Belongs to the thiolase family
M5E02_15625	COG1024	Enoyl-CoA hydratase
M5E02_15625	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E02_15640	COG5577	PFAM Coat F domain
M5E02_15650	COG1120	ATPase activity
M5E02_15660	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_15665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E02_15670	COG0745	RESPONSE REGULATOR receiver
M5E02_15675	COG2205	protein histidine kinase activity
M5E02_15675	COG2770	Histidine kinase
M5E02_15685	COG1309	transcriptional regulator
M5E02_15690	COG0114	fumarate hydratase activity
M5E02_15700	COG0697	spore germination
M5E02_15705	COG0814	amino acid
M5E02_15720	COG2197	response regulator
M5E02_15725	COG4585	Histidine kinase
M5E02_15730	COG4758	membrane
M5E02_15740	COG1842	Phage shock protein A
M5E02_15745	COG4758	membrane
M5E02_15750	COG1917	Cupin 2, conserved barrel domain protein
M5E02_15750	COG4977	sequence-specific DNA binding
M5E02_15760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_15765	COG0492	ferredoxin-NADP+ reductase activity
M5E02_15770	COG2096	Adenosyltransferase
M5E02_15780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
M5E02_15790	COG2204	response regulator
M5E02_15805	COG1454	alcohol dehydrogenase
M5E02_15810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M5E02_15820	COG1120	ATPase activity
M5E02_15825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_15830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_15840	COG2721	sulfolactate sulfo-lyase activity
M5E02_15845	COG0246	Mannitol dehydrogenase
M5E02_15850	COG1609	Transcriptional regulator
M5E02_15855	COG1904	glucuronate isomerase
M5E02_15860	COG2205	protein histidine kinase activity
M5E02_15865	COG0745	RESPONSE REGULATOR receiver
M5E02_15870	COG1120	ATPase activity
M5E02_15875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_15880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_15885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_15890	COG0531	amino acid
M5E02_15905	COG1988	membrane-bound metal-dependent
M5E02_15910	COG1368	sulfuric ester hydrolase activity
M5E02_15915	COG0725	ABC transporter, periplasmic molybdate-binding protein
M5E02_15920	COG4149	molybdate abc transporter
M5E02_15925	COG0656	L-ascorbic acid biosynthetic process
M5E02_15930	COG1940	carbohydrate kinase activity
M5E02_15935	COG0025	NhaP-type Na H and K H
M5E02_15940	COG2860	membrane
M5E02_15945	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M5E02_15950	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M5E02_15955	COG2217	Heavy metal translocating P-type atpase
M5E02_15960	COG1121	(ABC) transporter
M5E02_15965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M5E02_15970	COG0803	Belongs to the bacterial solute-binding protein 9 family
M5E02_15980	COG3226	Transcriptional regulator
M5E02_15985	COG0784	Response regulator, receiver
M5E02_15990	COG4191	Histidine kinase
M5E02_15995	COG1027	Aspartate ammonia-lyase
M5E02_16005	COG2217	Heavy metal translocating P-type atpase
M5E02_16010	COG2608	mercury ion transmembrane transporter activity
M5E02_16015	COG1937	Protein conserved in bacteria
M5E02_16045	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M5E02_16050	COG0557	exoribonuclease II activity
M5E02_16055	COG1647	Serine aminopeptidase, S33
M5E02_16060	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M5E02_16065	COG2002	toxin-antitoxin pair type II binding
M5E02_16070	COG1476	TRANSCRIPTIONal
M5E02_16075	COG1396	sequence-specific DNA binding
M5E02_16080	COG1396	sequence-specific DNA binding
M5E02_16085	COG1733	regulation of RNA biosynthetic process
M5E02_16090	COG1174	glycine betaine transport
M5E02_16095	COG1732	Glycine betaine
M5E02_16100	COG1174	glycine betaine transport
M5E02_16105	COG1125	glycine betaine transport
M5E02_16105	COG0517	IMP dehydrogenase activity
M5E02_16110	COG1510	regulation of RNA biosynthetic process
M5E02_16115	COG2095	MarC family integral membrane protein
M5E02_16125	COG0456	acetyltransferase
M5E02_16145	COG1122	ATPase activity
M5E02_16155	COG0148	phosphopyruvate hydratase activity
M5E02_16160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
M5E02_16165	COG0149	triose-phosphate isomerase activity
M5E02_16170	COG0126	phosphoglycerate kinase activity
M5E02_16175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
M5E02_16180	COG2390	Transcriptional regulator
M5E02_16185	COG0833	amino acid
M5E02_16190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
M5E02_16195	COG3829	transcription factor binding
M5E02_16200	COG2186	Transcriptional regulator
M5E02_16205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
M5E02_16215	COG0534	Mate efflux family protein
M5E02_16225	COG0444	Belongs to the ABC transporter superfamily
M5E02_16230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
M5E02_16235	COG0601	transmembrane transport
M5E02_16240	COG0747	negative chemotaxis
M5E02_16245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E02_16250	COG0110	maltose O-acetyltransferase activity
M5E02_16255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
M5E02_16260	COG2244	polysaccharide biosynthetic process
M5E02_16265	COG5039	Polysaccharide pyruvyl transferase
M5E02_16270	COG1216	Glycosyl transferase, family 2
M5E02_16280	COG0438	transferase activity, transferring glycosyl groups
M5E02_16285	COG1215	transferase activity, transferring glycosyl groups
M5E02_16290	COG0438	transferase activity, transferring glycosyl groups
M5E02_16295	COG1086	Polysaccharide biosynthesis protein
M5E02_16300	COG0489	protein tyrosine kinase activity
M5E02_16305	COG3944	biosynthesis protein
M5E02_16310	COG1396	sequence-specific DNA binding
M5E02_16320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_16325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_16330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
M5E02_16335	COG0726	polysaccharide deacetylase
M5E02_16340	COG0488	(ABC) transporter
M5E02_16350	COG1819	glycosyl
M5E02_16355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_16365	COG0740	serine-type endopeptidase activity
M5E02_16370	COG1611	Belongs to the LOG family
M5E02_16375	COG1694	Mazg nucleotide pyrophosphohydrolase
M5E02_16380	COG0659	secondary active sulfate transmembrane transporter activity
M5E02_16385	COG0288	reversible hydration of carbon dioxide
M5E02_16390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
M5E02_16410	COG2162	N-hydroxyarylamine O-acetyltransferase activity
M5E02_16415	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_16420	COG1481	regulation of sporulation
M5E02_16425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
M5E02_16430	COG1660	Displays ATPase and GTPase activities
M5E02_16435	COG1051	belongs to the nudix hydrolase family
M5E02_16440	COG0492	ferredoxin-NADP+ reductase activity
M5E02_16445	COG0791	NLP P60 protein
M5E02_16445	COG3883	PFAM NLP P60 protein
M5E02_16450	COG0457	Tetratricopeptide repeat
M5E02_16455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
M5E02_16455	COG0140	phosphoribosyl-ATP diphosphatase activity
M5E02_16460	COG0107	imidazoleglycerol-phosphate synthase activity
M5E02_16465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
M5E02_16470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
M5E02_16475	COG0131	Imidazoleglycerol-phosphate dehydratase
M5E02_16480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
M5E02_16485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
M5E02_16490	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
M5E02_16495	COG4990	cell redox homeostasis
M5E02_16505	COG2910	NAD(P)H-binding
M5E02_16510	COG1959	2 iron, 2 sulfur cluster binding
M5E02_16515	COG0110	maltose O-acetyltransferase activity
M5E02_16520	COG0546	phosphoglycolate phosphatase activity
M5E02_16525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
M5E02_16535	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
M5E02_16540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
M5E02_16545	COG0363	glucosamine-6-phosphate deaminase activity
M5E02_16550	COG2188	Transcriptional regulator
M5E02_16555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
M5E02_16560	COG1950	PFAM Membrane protein of
M5E02_16565	COG1983	PspC domain protein
M5E02_16570	COG3595	metallopeptidase activity
M5E02_16585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M5E02_16595	COG4897	Protein conserved in bacteria
M5E02_16600	COG0574	Belongs to the PEP-utilizing enzyme family
M5E02_16600	COG3848	Pyruvate phosphate dikinase
M5E02_16605	COG1309	transcriptional regulator
M5E02_16610	COG2814	Major facilitator Superfamily
M5E02_16620	COG0745	RESPONSE REGULATOR receiver
M5E02_16625	COG5002	protein histidine kinase activity
M5E02_16630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
M5E02_16635	COG0463	Glycosyl transferase, family 2
M5E02_16640	COG1113	amino acid transport
M5E02_16645	COG0778	Nitroreductase
M5E02_16650	COG1733	regulation of RNA biosynthetic process
M5E02_16655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E02_16665	COG0793	Belongs to the peptidase S41A family
M5E02_16665	COG3409	Peptidoglycan-binding domain 1 protein
M5E02_16670	COG0730	response to heat
M5E02_16675	COG0791	NLP P60 protein
M5E02_16675	COG3883	PFAM NLP P60 protein
M5E02_16680	COG2177	Part of the ABC transporter FtsEX involved in
M5E02_16685	COG2884	Cell division ATP-binding protein ftsE
M5E02_16690	COG2010	Cytochrome c
M5E02_16695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
M5E02_16715	COG0653	protein targeting
M5E02_16720	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
M5E02_16725	COG0840	transmembrane signaling receptor activity
M5E02_16740	COG1516	flagellar protein fliS
M5E02_16745	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
M5E02_16750	COG1334	flagellar protein FlaG
M5E02_16755	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
M5E02_16760	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
M5E02_16770	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
M5E02_16775	COG4786	Flagellar basal body rod
M5E02_16775	COG1256	bacterial-type flagellum assembly
M5E02_16780	COG3418	PFAM FlgN family protein
M5E02_16795	COG1040	competence protein
M5E02_16805	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
M5E02_16810	COG1307	EDD domain protein, DegV family
M5E02_16815	COG2197	response regulator
M5E02_16820	COG4585	Histidine kinase
M5E02_16825	COG1739	Uncharacterized protein family UPF0029
M5E02_16830	COG1316	TRANSCRIPTIONal
M5E02_16835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M5E02_16840	COG0438	transferase activity, transferring glycosyl groups
M5E02_16845	COG1215	transferase activity, transferring glycosyl groups
M5E02_16850	COG3206	protein involved in exopolysaccharide biosynthesis
M5E02_16855	COG3307	-O-antigen
M5E02_16860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
M5E02_16865	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5E02_16870	COG0297	glycogen (starch) synthase activity
M5E02_16870	COG0438	transferase activity, transferring glycosyl groups
M5E02_16875	COG2244	polysaccharide biosynthetic process
M5E02_16890	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E02_16890	COG2247	cell wall binding repeat
M5E02_16895	COG0860	N-Acetylmuramoyl-L-alanine amidase
M5E02_16895	COG2247	cell wall binding repeat
M5E02_16900	COG2247	cell wall binding repeat
M5E02_16900	COG2385	sporulation resulting in formation of a cellular spore
M5E02_16910	COG1316	TRANSCRIPTIONal
M5E02_16915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
M5E02_16920	COG1210	Utp--glucose-1-phosphate uridylyltransferase
M5E02_16925	COG1134	teichoic acid transport
M5E02_16930	COG1682	transport, permease protein
M5E02_16935	COG0463	Glycosyl transferase, family 2
M5E02_16935	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E02_16940	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E02_16950	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
M5E02_16955	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
M5E02_16960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E02_16965	COG4193	domain, Protein
M5E02_16970	COG1482	cell wall glycoprotein biosynthetic process
M5E02_16980	COG1175	transmembrane transport
M5E02_16985	COG1653	transport
M5E02_16990	COG2197	response regulator
M5E02_16995	COG2972	Histidine kinase
M5E02_17005	COG0454	-acetyltransferase
M5E02_17010	COG0800	Aldolase
M5E02_17015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E02_17020	COG1609	Transcriptional regulator
M5E02_17025	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
M5E02_17030	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_17035	COG0697	spore germination
M5E02_17040	COG0814	amino acid
M5E02_17055	COG2814	Major facilitator Superfamily
M5E02_17060	COG1316	TRANSCRIPTIONal
M5E02_17065	COG0561	phosphatase activity
M5E02_17070	COG0791	NLP P60 protein
M5E02_17080	COG2843	Capsule synthesis protein
M5E02_17090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M5E02_17095	COG0697	spore germination
M5E02_17110	COG1609	Transcriptional regulator
M5E02_17115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
M5E02_17120	COG1869	D-ribose catabolic process
M5E02_17125	COG1129	ABC transporter
M5E02_17130	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5E02_17135	COG1879	ABC-type sugar transport system periplasmic component
M5E02_17140	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
M5E02_17145	COG0583	DNA-binding transcription factor activity
M5E02_17150	COG0028	Belongs to the TPP enzyme family
M5E02_17155	COG3527	Alpha-acetolactate decarboxylase
M5E02_17160	COG1522	sequence-specific DNA binding
M5E02_17165	COG2059	Chromate
M5E02_17170	COG2059	Chromate
M5E02_17175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M5E02_17185	COG4715	Zinc finger, swim domain protein
M5E02_17190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
M5E02_17195	COG2202	Pas domain
M5E02_17195	COG1366	Belongs to the anti-sigma-factor antagonist family
M5E02_17200	COG0561	phosphatase activity
M5E02_17215	COG1970	mechanosensitive ion channel activity
M5E02_17220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M5E02_17225	COG0457	Tetratricopeptide repeat
M5E02_17230	COG4786	Flagellar basal body rod
M5E02_17235	COG4786	Flagellar basal body rod
M5E02_17240	COG1077	Cell shape determining protein MreB Mrl
M5E02_17245	COG1609	Transcriptional regulator
M5E02_17255	COG1846	Transcriptional regulator
M5E02_17260	COG2814	Major facilitator Superfamily
M5E02_17265	COG0671	phosphoesterase, PA-phosphatase related
M5E02_17270	COG0477	Major facilitator Superfamily
M5E02_17275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_17280	COG0765	amino acid transport
M5E02_17290	COG0004	ammonium transporteR
M5E02_17295	COG0347	Belongs to the P(II) protein family
M5E02_17300	COG0739	heme binding
M5E02_17305	COG1247	-acetyltransferase
M5E02_17345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M5E02_17350	COG0523	cobalamin synthesis protein
M5E02_17355	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M5E02_17360	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
M5E02_17365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
M5E02_17370	COG2223	nitrite transmembrane transporter activity
M5E02_17375	COG3383	formate dehydrogenase (NAD+) activity
M5E02_17380	COG2304	oxidoreductase activity
M5E02_17385	COG2304	oxidoreductase activity
M5E02_17390	COG2385	sporulation resulting in formation of a cellular spore
M5E02_17395	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5E02_17405	COG4836	Membrane
M5E02_17415	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M5E02_17420	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M5E02_17425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M5E02_17430	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M5E02_17435	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5E02_17440	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M5E02_17445	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M5E02_17450	COG0356	it plays a direct role in the translocation of protons across the membrane
M5E02_17460	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
M5E02_17465	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M5E02_17470	COG4475	Protein of unknown function (DUF436)
M5E02_17475	COG0698	ribose 5-phosphate isomerase
M5E02_17480	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
M5E02_17485	COG1971	Probably functions as a manganese efflux pump
M5E02_17490	COG0009	L-threonylcarbamoyladenylate synthase
M5E02_17495	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
M5E02_17510	COG2890	protein-(glutamine-N5) methyltransferase activity
M5E02_17515	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M5E02_17520	COG0789	Transcriptional regulator
M5E02_17525	COG0679	Auxin Efflux Carrier
M5E02_17530	COG0281	malic enzyme
M5E02_17535	COG1435	thymidine kinase activity
M5E02_17540	COG0254	rRNA binding
M5E02_17545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M5E02_17550	COG1494	fructose-1,6-bisphosphatase
M5E02_17555	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M5E02_17560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
M5E02_17565	COG0191	fructose-bisphosphate aldolase activity
M5E02_17570	COG2204	response regulator
M5E02_17575	COG4821	SIS domain
M5E02_17580	COG0504	CTP synthase activity
M5E02_17585	COG3343	RNA polymerase activity
M5E02_17595	COG1960	acyl-CoA dehydrogenase activity
M5E02_17600	COG1960	acyl-CoA dehydrogenase activity
M5E02_17605	COG1250	3-hydroxyacyl-CoA dehydrogenase
M5E02_17610	COG0183	Belongs to the thiolase family
M5E02_17615	COG0247	lactate metabolic process
M5E02_17615	COG2181	nitrate reductase activity
M5E02_17620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E02_17625	COG4294	response to UV
M5E02_17635	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E02_17640	COG1132	(ABC) transporter
M5E02_17645	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M5E02_17650	COG1619	proteins homologs of microcin C7 resistance protein MccF
M5E02_17660	COG0018	arginyl-trna synthetase
M5E02_17665	COG4506	Protein conserved in bacteria
M5E02_17675	COG0010	Belongs to the arginase family
M5E02_17680	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
M5E02_17685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M5E02_17695	COG1994	Peptidase M50
M5E02_17700	COG1942	4-Oxalocrotonate Tautomerase
M5E02_17710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_17715	COG0583	DNA-binding transcription factor activity
M5E02_17720	COG0431	NADPH-dependent FMN reductase
M5E02_17725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_17730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M5E02_17735	COG0454	-acetyltransferase
M5E02_17740	COG0765	amino acid transport
M5E02_17745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_17755	COG1126	abc transporter atp-binding protein
M5E02_17760	COG3465	dGTPase activity
M5E02_17765	COG1078	dGTPase activity
M5E02_17770	COG4844	belongs to the
M5E02_17820	COG5444	nuclease activity
M5E02_17850	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
M5E02_17860	COG0280	phosphate acetyltransferase
M5E02_17870	COG2814	Major facilitator Superfamily
M5E02_17875	COG1522	sequence-specific DNA binding
M5E02_17880	COG2814	Major facilitator Superfamily
M5E02_17885	COG0077	Prephenate dehydratase
M5E02_17895	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_17900	COG0151	Belongs to the GarS family
M5E02_17905	COG0436	Aminotransferase
M5E02_17910	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_17915	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
M5E02_17920	COG1091	dTDP-4-dehydrorhamnose reductase activity
M5E02_17925	COG1088	dTDP-glucose 4,6-dehydratase activity
M5E02_17930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
M5E02_17935	COG3980	spore coat polysaccharide biosynthesis protein
M5E02_17940	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
M5E02_17945	COG2089	acid synthase
M5E02_17950	COG0456	acetyltransferase
M5E02_17955	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
M5E02_17960	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
M5E02_17965	COG0463	Glycosyl transferase, family 2
M5E02_17985	COG2363	Small membrane protein
M5E02_17990	COG2233	PERMEase
M5E02_18000	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_18005	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
M5E02_18010	COG1216	Glycosyl transferase, family 2
M5E02_18020	COG0351	phosphomethylpyrimidine kinase
M5E02_18040	COG3964	amidohydrolase
M5E02_18045	COG1621	beta-fructofuranosidase activity
M5E02_18050	COG1263	PTS System
M5E02_18050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_18055	COG3711	transcriptional antiterminator
M5E02_18065	COG1404	Belongs to the peptidase S8 family
M5E02_18070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_18075	COG0778	Nitroreductase
M5E02_18080	COG0772	Belongs to the SEDS family
M5E02_18090	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
M5E02_18095	COG1845	cytochrome c oxidase, subunit III
M5E02_18100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M5E02_18105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M5E02_18115	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
M5E02_18120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
M5E02_18125	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
M5E02_18140	COG2246	polysaccharide biosynthetic process
M5E02_18160	COG3162	membrane
M5E02_18165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M5E02_18175	COG0352	thiamine-phosphate diphosphorylase activity
M5E02_18180	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
M5E02_18185	COG0583	DNA-binding transcription factor activity
M5E02_18190	COG1380	Effector of murein hydrolase LrgA
M5E02_18195	COG1346	cytolysis
M5E02_18200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
M5E02_18205	COG0346	lactoylglutathione lyase activity
M5E02_18215	COG0765	amino acid transport
M5E02_18220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M5E02_18225	COG0457	Tetratricopeptide repeat
M5E02_18235	COG2357	RelA SpoT domain protein
M5E02_18240	COG1172	Belongs to the binding-protein-dependent transport system permease family
M5E02_18245	COG1129	ABC transporter
M5E02_18255	COG3420	alginic acid biosynthetic process
M5E02_18260	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M5E02_18270	COG1486	melibiose metabolic process
M5E02_18275	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E02_18280	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E02_18285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E02_18290	COG3711	transcriptional antiterminator
M5E02_18290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_18310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
M5E02_18325	COG1595	DNA-templated transcription, initiation
M5E02_18335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
M5E02_18340	COG4988	ABC transporter
M5E02_18345	COG1294	oxidase, subunit
M5E02_18350	COG1271	oxidase subunit
M5E02_18375	COG4509	Sortase family
M5E02_18400	COG5386	Cell surface protein
M5E02_18405	COG5386	Cell surface protein
M5E02_18410	COG1733	regulation of RNA biosynthetic process
M5E02_18415	COG2514	catechol 2,3-dioxygenase activity
M5E02_18420	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E02_18420	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
M5E02_18425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E02_18425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
M5E02_18435	COG0726	polysaccharide deacetylase
M5E02_18440	COG1447	Phosphotransferase system cellobiose-specific component IIA
M5E02_18445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E02_18450	COG2723	6-phospho-beta-galactosidase activity
M5E02_18455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
M5E02_18460	COG3711	transcriptional antiterminator
M5E02_18460	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
M5E02_18485	COG1757	Na H antiporter
M5E02_18490	COG1027	Aspartate ammonia-lyase
M5E02_18495	COG0252	asparaginase activity
M5E02_18500	COG1396	sequence-specific DNA binding
M5E02_18525	COG4842	Belongs to the WXG100 family
M5E02_18530	COG2195	Cleaves the N-terminal amino acid of tripeptides
M5E02_18545	COG1737	Transcriptional regulator
M5E02_18550	COG2084	Dehydrogenase
M5E02_18560	COG2610	gluconate transmembrane transporter activity
M5E02_18565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
M5E02_18570	COG2723	6-phospho-beta-galactosidase activity
M5E02_18575	COG1263	PTS System
M5E02_18575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_18575	COG2190	(PTS) system
M5E02_18580	COG3711	transcriptional antiterminator
M5E02_18585	COG2011	ABC-type metal ion transport system permease component
M5E02_18595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_18610	COG1464	Belongs to the NlpA lipoprotein family
M5E02_18615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
M5E02_18620	COG0583	DNA-binding transcription factor activity
M5E02_18625	COG3878	Protein conserved in bacteria
M5E02_18635	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E02_18640	COG1122	ATPase activity
M5E02_18645	COG4721	ABC-type cobalt transport system, permease component
M5E02_18650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
M5E02_18685	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
M5E02_18690	COG0778	Nitroreductase
M5E02_18700	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
M5E02_18705	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
M5E02_18710	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
M5E02_18715	COG2390	Transcriptional regulator
M5E02_18725	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
M5E02_18725	COG2755	lipolytic protein G-D-S-L family
M5E02_18745	COG0561	phosphatase activity
M5E02_18750	COG0789	Transcriptional regulator
M5E02_18755	COG0673	inositol 2-dehydrogenase activity
M5E02_18760	COG0840	transmembrane signaling receptor activity
M5E02_18765	COG1113	amino acid transport
M5E02_18770	COG4335	DNA alkylation repair
M5E02_18780	COG1070	Carbohydrate kinase
M5E02_18785	COG1737	Transcriptional regulator
M5E02_18790	COG1957	nucleoside hydrolase
M5E02_18815	COG0583	DNA-binding transcription factor activity
M5E02_18820	COG1609	Transcriptional regulator
M5E02_18825	COG2182	Extracellular solute-binding protein
M5E02_18830	COG1175	transmembrane transport
M5E02_18835	COG3833	ABC-type maltose transport systems, permease component
M5E02_18845	COG1874	Beta-galactosidase
M5E02_18850	COG2851	Citrate transporter
M5E02_18860	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
M5E02_18865	COG1131	(ABC) transporter
M5E02_18870	COG2824	Alkylphosphonate utilization operon protein PhnA
M5E02_18875	COG1929	Belongs to the glycerate kinase type-1 family
M5E02_18880	COG2610	gluconate transmembrane transporter activity
M5E02_18885	COG3835	regulator
M5E02_18890	COG1309	transcriptional regulator
M5E02_18895	COG2814	Major facilitator Superfamily
M5E02_18905	COG0577	efflux transmembrane transporter activity
M5E02_18905	COG1136	(ABC) transporter
M5E02_18915	COG0457	Tetratricopeptide repeat
M5E02_18960	COG1113	amino acid transport
M5E02_18965	COG1609	Transcriptional regulator
M5E02_18970	COG2814	Major facilitator Superfamily
M5E02_18980	COG2814	Major facilitator Superfamily
M5E02_18985	COG2723	6-phospho-beta-galactosidase activity
M5E02_18995	COG2190	(PTS) system
M5E02_18995	COG1263	PTS System
M5E02_18995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
M5E02_19005	COG1012	belongs to the aldehyde dehydrogenase family
M5E02_19020	COG0163	prenyltransferase activity
M5E02_19025	COG0583	DNA-binding transcription factor activity
M5E02_19030	COG2723	6-phospho-beta-galactosidase activity
M5E02_19040	COG2188	Transcriptional regulator
M5E02_19055	COG0384	phenazine biosynthesis protein PhzF
M5E02_19060	COG0583	DNA-binding transcription factor activity
M5E02_19075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
M5E02_19085	COG2814	Major facilitator Superfamily
M5E02_19090	COG0640	Transcriptional regulator
M5E02_19110	COG0210	DNA helicase
M5E02_19120	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
M5E02_19130	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
M5E02_19140	COG4720	Psort location CytoplasmicMembrane, score
M5E02_19160	COG0456	acetyltransferase
M5E02_19165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M5E02_19170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
M5E02_19175	COG4853	Protein conserved in bacteria
M5E02_19180	COG4863	YycH protein
M5E02_19185	COG5002	protein histidine kinase activity
M5E02_19190	COG0745	RESPONSE REGULATOR receiver
M5E02_19215	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
M5E02_19225	COG2311	Membrane
M5E02_19230	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
M5E02_19235	COG0346	lactoylglutathione lyase activity
M5E02_19240	COG0305	Participates in initiation and elongation during chromosome replication
M5E02_19260	COG2819	hydrolase of the alpha beta superfamily
M5E02_19265	COG1028	Short-chain dehydrogenase reductase Sdr
M5E02_19270	COG1169	isochorismate synthase
M5E02_19275	COG1021	2,3-dihydroxybenzoate-AMP ligase
M5E02_19280	COG1535	isochorismatase
M5E02_19280	COG3433	isochorismatase activity
M5E02_19285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
M5E02_19290	COG3251	PFAM MbtH domain protein
M5E02_19295	COG2207	Transcriptional regulator
M5E02_19295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_19300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
M5E02_19305	COG2819	hydrolase of the alpha beta superfamily
M5E02_19310	COG3093	addiction module antidote protein HigA
M5E02_19315	COG2807	transmembrane transport
M5E02_19320	COG0359	binds to the 23S rRNA
M5E02_19325	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
M5E02_19330	COG4241	membrane
M5E02_19335	COG1227	inorganic diphosphatase activity
M5E02_19345	COG1595	DNA-templated transcription, initiation
M5E02_19355	COG0753	catalase activity
M5E02_19360	COG0655	NAD(P)H dehydrogenase (quinone) activity
M5E02_19365	COG0400	carboxylic ester hydrolase activity
M5E02_19370	COG0346	lactoylglutathione lyase activity
M5E02_19375	COG1174	glycine betaine transport
M5E02_19380	COG0517	IMP dehydrogenase activity
M5E02_19380	COG1125	glycine betaine transport
M5E02_19385	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M5E02_19390	COG0629	single-stranded DNA binding
M5E02_19395	COG0360	Binds together with S18 to 16S ribosomal RNA
M5E02_19400	COG0012	GTP binding
M5E02_19405	COG4481	Protein conserved in bacteria
M5E02_19420	COG3949	Membrane
M5E02_19430	COG1475	DNA binding
M5E02_19435	COG1192	Involved in chromosome partitioning
M5E02_19440	COG1475	DNA binding
M5E02_19445	COG0357	Ribosomal RNA small subunit methyltransferase G
M5E02_19450	COG0445	tRNA wobble uridine modification
M5E02_19455	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M5E02_19460	COG1847	R3H domain protein
M5E02_19465	COG0706	membrane insertase activity
M5E02_19470	COG0594	ribonuclease P activity
M5E02_19475	COG0230	Belongs to the bacterial ribosomal protein bL34 family