locus-tag	class	description
O0R49_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O0R49_00010	COG0592	DNA-directed DNA polymerase activity
O0R49_00015	COG2501	S4 domain
O0R49_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O0R49_00030	COG0187	DNA topoisomerase II activity
O0R49_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O0R49_00070	COG0516	GMP reductase activity
O0R49_00070	COG0517	IMP dehydrogenase activity
O0R49_00075	COG1686	Belongs to the peptidase S11 family
O0R49_00080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R49_00085	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O0R49_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
O0R49_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O0R49_00100	COG0840	transmembrane signaling receptor activity
O0R49_00110	COG1428	Deoxynucleoside kinase
O0R49_00115	COG1428	Deoxynucleoside kinase
O0R49_00120	COG3858	chitin binding
O0R49_00120	COG1388	LysM domain
O0R49_00125	COG1335	isochorismatase
O0R49_00130	COG0590	tRNA wobble adenosine to inosine editing
O0R49_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O0R49_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O0R49_00150	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O0R49_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
O0R49_00200	COG3853	Toxic anion resistance protein (TelA)
O0R49_00205	COG1982	Orn Lys Arg decarboxylase major
O0R49_00210	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
O0R49_00215	COG3870	Protein conserved in bacteria
O0R49_00220	COG1728	Protein conserved in bacteria
O0R49_00225	COG0470	DNA polymerase III
O0R49_00230	COG1774	PSP1 C-terminal conserved region
O0R49_00235	COG4467	Involved in initiation control of chromosome replication
O0R49_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O0R49_00245	COG2827	Endonuclease containing a URI domain
O0R49_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
O0R49_00255	COG2002	toxin-antitoxin pair type II binding
O0R49_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R49_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R49_00265	COG0084	hydrolase, TatD family'
O0R49_00270	COG3583	domain protein
O0R49_00270	COG3584	3D domain protein
O0R49_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O0R49_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O0R49_00290	COG4466	Protein conserved in bacteria
O0R49_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O0R49_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0R49_00310	COG0251	oxidation-reduction process
O0R49_00315	COG2088	sporulation resulting in formation of a cellular spore
O0R49_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
O0R49_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O0R49_00335	COG0193	aminoacyl-tRNA hydrolase activity
O0R49_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
O0R49_00350	COG2002	toxin-antitoxin pair type II binding
O0R49_00355	COG2244	polysaccharide biosynthetic process
O0R49_00360	COG3956	TIGRFAM MazG family protein
O0R49_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
O0R49_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
O0R49_00385	COG1098	S1 RNA binding domain
O0R49_00400	COG2208	phosphoserine phosphatase activity
O0R49_00405	COG2304	oxidoreductase activity
O0R49_00410	COG0515	serine threonine protein kinase
O0R49_00415	COG0037	tRNA processing
O0R49_00420	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
O0R49_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O0R49_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O0R49_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
O0R49_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O0R49_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R49_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O0R49_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
O0R49_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R49_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O0R49_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
O0R49_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
O0R49_00480	COG1396	sequence-specific DNA binding
O0R49_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O0R49_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O0R49_00570	COG4463	regulation of RNA biosynthetic process
O0R49_00575	COG3880	PFAM UvrB UvrC protein
O0R49_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
O0R49_00585	COG0542	response to heat
O0R49_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O0R49_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O0R49_00600	COG4956	integral membrane protein (PIN domain superfamily)
O0R49_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O0R49_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O0R49_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O0R49_00620	COG1045	serine acetyltransferase
O0R49_00625	COG0215	cysteine-tRNA ligase activity
O0R49_00630	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
O0R49_00635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O0R49_00640	COG3688	RNA-binding protein containing a PIN domain
O0R49_00645	COG1595	DNA-templated transcription, initiation
O0R49_00650	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O0R49_00655	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O0R49_00660	COG0250	Participates in transcription elongation, termination and antitermination
O0R49_00670	COG0081	regulation of translation
O0R49_00675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
O0R49_00680	COG0222	ribosome binding
O0R49_00685	COG2813	Specifically methylates the guanine in position
O0R49_00690	COG0085	RNA polymerase activity
O0R49_00695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O0R49_00700	COG1358	cellular component organization or biogenesis
O0R49_00705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O0R49_00710	COG0049	tRNA binding
O0R49_00715	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O0R49_00720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O0R49_00725	COG0596	Alpha beta hydrolase
O0R49_00735	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O0R49_00740	COG0088	Forms part of the polypeptide exit tunnel
O0R49_00745	COG0089	rRNA binding
O0R49_00750	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O0R49_00755	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O0R49_00760	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O0R49_00765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O0R49_00775	COG0255	Belongs to the universal ribosomal protein uL29 family
O0R49_00780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O0R49_00785	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O0R49_00790	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O0R49_00795	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O0R49_00800	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O0R49_00805	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O0R49_00810	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O0R49_00815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O0R49_00820	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O0R49_00825	COG1841	ribosomal large subunit assembly
O0R49_00830	COG0200	Binds to the 23S rRNA
O0R49_00835	COG0201	protein transport
O0R49_00840	COG0563	adenylate kinase activity
O0R49_00845	COG0024	Methionine aminopeptidase
O0R49_00855	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O0R49_00860	COG0257	Belongs to the bacterial ribosomal protein bL36 family
O0R49_00865	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O0R49_00870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O0R49_00875	COG0202	RNA polymerase activity
O0R49_00880	COG0203	ribosomal protein L17
O0R49_00885	COG1122	ATPase activity
O0R49_00890	COG1122	ATPase activity
O0R49_00895	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O0R49_00900	COG0101	tRNA pseudouridine synthase activity
O0R49_00905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O0R49_00910	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O0R49_00915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_00940	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_00945	COG0489	protein tyrosine kinase activity
O0R49_00955	COG2194	sulfuric ester hydrolase activity
O0R49_00960	COG0726	polysaccharide deacetylase
O0R49_00995	COG0385	Bile acid
O0R49_01000	COG3876	Protein conserved in bacteria
O0R49_01005	COG1472	Belongs to the glycosyl hydrolase 3 family
O0R49_01010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O0R49_01015	COG1263	PTS System
O0R49_01015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_01020	COG1737	Transcriptional regulator
O0R49_01025	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O0R49_01060	COG1595	DNA-templated transcription, initiation
O0R49_01065	COG5662	AntiSigma factor
O0R49_01070	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O0R49_01075	COG4856	YbbR-like protein
O0R49_01080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O0R49_01085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O0R49_01100	COG1131	(ABC) transporter
O0R49_01125	COG3402	PFAM membrane-flanked domain
O0R49_01130	COG1131	(ABC) transporter
O0R49_01185	COG2311	Membrane
O0R49_01205	COG1476	TRANSCRIPTIONal
O0R49_01215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O0R49_01220	COG1309	transcriptional regulator
O0R49_01235	COG1113	amino acid transport
O0R49_01240	COG0584	glycerophosphoryl diester phosphodiesterase
O0R49_01245	COG2271	Major facilitator Superfamily
O0R49_01255	COG1331	Highly conserved protein containing a thioredoxin domain
O0R49_01260	COG1331	Highly conserved protein containing a thioredoxin domain
O0R49_01265	COG2364	Membrane
O0R49_01270	COG2153	protein acetylation
O0R49_01275	COG1846	Transcriptional regulator
O0R49_01285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0R49_01310	COG1937	Protein conserved in bacteria
O0R49_01315	COG2210	Belongs to the sulfur carrier protein TusA family
O0R49_01325	COG0425	Belongs to the sulfur carrier protein TusA family
O0R49_01325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R49_01330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R49_01330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R49_01335	COG0425	Belongs to the sulfur carrier protein TusA family
O0R49_01340	COG0730	response to heat
O0R49_01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O0R49_01355	COG2814	Major facilitator Superfamily
O0R49_01365	COG1846	Transcriptional regulator
O0R49_01375	COG1683	Conserved Protein
O0R49_01385	COG0656	L-ascorbic acid biosynthetic process
O0R49_01390	COG0371	Dehydrogenase
O0R49_01395	COG1054	Belongs to the UPF0176 family
O0R49_01400	COG0531	amino acid
O0R49_01410	COG3711	transcriptional antiterminator
O0R49_01415	COG2190	(PTS) system
O0R49_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_01415	COG1263	PTS System
O0R49_01420	COG2723	6-phospho-beta-galactosidase activity
O0R49_01435	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_01435	COG3711	transcriptional antiterminator
O0R49_01440	COG1940	carbohydrate kinase activity
O0R49_01445	COG0383	alpha-mannosidase activity
O0R49_01450	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_01455	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_01465	COG1404	Belongs to the peptidase S8 family
O0R49_01480	COG0833	amino acid
O0R49_01485	COG2040	homocysteine
O0R49_01490	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R49_01495	COG1695	Transcriptional regulator
O0R49_01510	COG2814	Major facilitator Superfamily
O0R49_01515	COG0456	acetyltransferase
O0R49_01530	COG1404	Belongs to the peptidase S8 family
O0R49_01540	COG1309	transcriptional regulator
O0R49_01545	COG1917	Cupin 2, conserved barrel domain protein
O0R49_01550	COG1063	alcohol dehydrogenase
O0R49_01555	COG1846	Transcriptional regulator
O0R49_01560	COG0318	PFAM AMP-dependent synthetase and ligase
O0R49_01565	COG0531	amino acid
O0R49_01575	COG0596	Alpha beta hydrolase
O0R49_01580	COG1115	amino acid carrier protein
O0R49_01585	COG2066	Belongs to the glutaminase family
O0R49_01590	COG4191	Histidine kinase
O0R49_01595	COG0784	Response regulator, receiver
O0R49_01600	COG1405	negative regulation of cell septum assembly
O0R49_01600	COG3012	SEC-C Motif Domain Protein
O0R49_01610	COG2197	response regulator
O0R49_01615	COG4585	Histidine kinase
O0R49_01625	COG0667	Aldo Keto reductase
O0R49_01630	COG3290	protein histidine kinase activity
O0R49_01635	COG3279	Response regulator of the LytR AlgR family
O0R49_01640	COG4555	ABC transporter
O0R49_01645	COG1668	transmembrane transport
O0R49_01660	COG3773	Cell wall hydrolase
O0R49_01665	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_01675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_01680	COG2310	stress, protein
O0R49_01685	COG2310	stress, protein
O0R49_01690	COG2310	stress, protein
O0R49_01695	COG0861	Integral membrane protein TerC family
O0R49_01725	COG3853	Toxic anion resistance protein (TelA)
O0R49_01730	COG0517	IMP dehydrogenase activity
O0R49_01730	COG4175	Glycine betaine
O0R49_01735	COG4176	ABC-type proline glycine betaine transport system permease component
O0R49_01740	COG2113	Glycine betaine
O0R49_01755	COG1473	amidohydrolase
O0R49_01760	COG1288	antiporter activity
O0R49_01765	COG0039	L-malate dehydrogenase activity
O0R49_01770	COG1620	l-lactate permease
O0R49_01775	COG1609	Transcriptional regulator
O0R49_01780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R49_01785	COG0561	phosphatase activity
O0R49_01790	COG0673	inositol 2-dehydrogenase activity
O0R49_01795	COG0738	Major facilitator superfamily
O0R49_01800	COG1280	lysine exporter protein (LysE YggA)
O0R49_01810	COG3403	YqcI/YcgG family
O0R49_01815	COG1113	amino acid transport
O0R49_01820	COG3665	Urea carboxylase-associated protein
O0R49_01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O0R49_01835	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_01840	COG0710	3-dehydroquinate dehydratase activity
O0R49_01845	COG0028	Belongs to the TPP enzyme family
O0R49_01855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O0R49_01860	COG2271	Major facilitator Superfamily
O0R49_01875	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O0R49_01880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O0R49_01890	COG0477	Major facilitator Superfamily
O0R49_01895	COG2226	methyltransferase
O0R49_01900	COG0583	DNA-binding transcription factor activity
O0R49_01905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0R49_01910	COG3458	cephalosporin-C deacetylase activity
O0R49_01920	COG3541	Predicted nucleotidyltransferase
O0R49_01925	COG0506	proline dehydrogenase activity
O0R49_01930	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_01935	COG2508	Transcriptional regulator
O0R49_01940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O0R49_01945	COG0765	amino acid transport
O0R49_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_01960	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O0R49_01965	COG1522	sequence-specific DNA binding
O0R49_01970	COG2746	aminoglycoside 3-N-acetyltransferase activity
O0R49_01980	COG3290	protein histidine kinase activity
O0R49_01980	COG0840	transmembrane signaling receptor activity
O0R49_01985	COG3209	COG3209 Rhs family protein
O0R49_02005	COG3842	ATPase activity
O0R49_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R49_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R49_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R49_02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
O0R49_02060	COG4555	ABC transporter
O0R49_02075	COG0697	spore germination
O0R49_02080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R49_02090	COG3708	Transcriptional regulator
O0R49_02090	COG2207	Transcriptional regulator
O0R49_02100	COG2364	Membrane
O0R49_02105	COG0737	Belongs to the 5'-nucleotidase family
O0R49_02110	COG3764	Sortase (surface protein transpeptidase)
O0R49_02115	COG2002	toxin-antitoxin pair type II binding
O0R49_02120	COG1126	abc transporter atp-binding protein
O0R49_02125	COG0765	amino acid transport
O0R49_02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_02135	COG0412	Dienelactone hydrolase
O0R49_02140	COG0833	amino acid
O0R49_02145	COG3104	oligopeptide transport
O0R49_02150	COG5434	Belongs to the glycosyl hydrolase 28 family
O0R49_02155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_02160	COG0456	acetyltransferase
O0R49_02165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_02170	COG0765	amino acid transport
O0R49_02175	COG1126	abc transporter atp-binding protein
O0R49_02180	COG1473	amidohydrolase
O0R49_02185	COG2079	MmgE PrpD family protein
O0R49_02190	COG0745	RESPONSE REGULATOR receiver
O0R49_02195	COG3850	Histidine kinase
O0R49_02195	COG5002	protein histidine kinase activity
O0R49_02200	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_02205	COG0527	aspartate kinase activity
O0R49_02210	COG2814	Major facilitator Superfamily
O0R49_02215	COG1309	transcriptional regulator
O0R49_02220	COG0640	Transcriptional regulator
O0R49_02225	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R49_02230	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O0R49_02235	COG0531	amino acid
O0R49_02240	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_02245	COG2249	NAD(P)H dehydrogenase (quinone) activity
O0R49_02250	COG4549	nuclear export factor GLE1
O0R49_02255	COG1276	copper resistance
O0R49_02255	COG2372	response to copper ion
O0R49_02260	COG2213	PTS system mannitol-specific
O0R49_02265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_02270	COG0246	Mannitol dehydrogenase
O0R49_02275	COG0840	transmembrane signaling receptor activity
O0R49_02285	COG4221	oxidoreductase activity
O0R49_02305	COG0346	lactoylglutathione lyase activity
O0R49_02315	COG0561	phosphatase activity
O0R49_02320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O0R49_02325	COG1914	H( )-stimulated, divalent metal cation uptake system
O0R49_02330	COG4336	lyase activity
O0R49_02335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O0R49_02340	COG1984	allophanate hydrolase subunit 2
O0R49_02345	COG1414	Transcriptional regulator
O0R49_02350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O0R49_02355	COG2755	lipolytic protein G-D-S-L family
O0R49_02365	COG3711	transcriptional antiterminator
O0R49_02370	COG2226	methyltransferase
O0R49_02375	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_02380	COG3871	stress protein (general stress protein 26)
O0R49_02405	COG2814	Major facilitator Superfamily
O0R49_02410	COG1802	Transcriptional regulator
O0R49_02415	COG1917	Cupin 2, conserved barrel domain protein
O0R49_02415	COG2207	Transcriptional regulator
O0R49_02420	COG0697	spore germination
O0R49_02425	COG0473	3-isopropylmalate dehydrogenase activity
O0R49_02430	COG0551	DNA topoisomerase type I activity
O0R49_02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O0R49_02435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
O0R49_02440	COG3706	GGDEF domain
O0R49_02445	COG5298	Protein conserved in bacteria
O0R49_02450	COG1215	transferase activity, transferring glycosyl groups
O0R49_02460	COG0531	amino acid
O0R49_02465	COG0028	Belongs to the TPP enzyme family
O0R49_02470	COG5444	nuclease activity
O0R49_02495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_02500	COG1914	H( )-stimulated, divalent metal cation uptake system
O0R49_02505	COG2261	transglycosylase associated protein
O0R49_02510	COG2217	Heavy metal translocating P-type atpase
O0R49_02515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
O0R49_02520	COG3290	protein histidine kinase activity
O0R49_02525	COG4565	transcriptional regulatory protein
O0R49_02530	COG1301	dicarboxylic acid transport
O0R49_02535	COG0628	permease
O0R49_02540	COG1301	dicarboxylic acid transport
O0R49_02545	COG1131	(ABC) transporter
O0R49_02550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O0R49_02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
O0R49_02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
O0R49_02590	COG0513	Belongs to the DEAD box helicase family
O0R49_02595	COG3402	PFAM membrane-flanked domain
O0R49_02600	COG3428	Bacterial PH domain
O0R49_02605	COG0705	Rhomboid family
O0R49_02610	COG0736	holo-[acyl-carrier-protein] synthase activity
O0R49_02615	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
O0R49_02620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O0R49_02625	COG0864	Transcriptional regulator
O0R49_02630	COG2337	Toxic component of a toxin-antitoxin (TA) module
O0R49_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_02640	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_02645	COG2172	sigma factor antagonist activity
O0R49_02650	COG2208	phosphoserine phosphatase activity
O0R49_02655	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_02660	COG2172	sigma factor antagonist activity
O0R49_02665	COG1191	sigma factor activity
O0R49_02670	COG2208	phosphoserine phosphatase activity
O0R49_02675	COG2183	response to ionizing radiation
O0R49_02685	COG3091	SprT-like family
O0R49_02690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R49_02695	COG0022	dehydrogenase e1 component
O0R49_02700	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R49_02705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R49_02710	COG3284	Transcriptional regulator
O0R49_02765	COG1278	Cold shock
O0R49_02770	COG1329	Transcriptional regulator
O0R49_02775	COG1064	alcohol dehydrogenase
O0R49_02780	COG0789	Transcriptional regulator
O0R49_02795	COG0477	Major facilitator Superfamily
O0R49_02800	COG0657	acetylesterase activity
O0R49_02810	COG4221	oxidoreductase activity
O0R49_02825	COG1404	Belongs to the peptidase S8 family
O0R49_02830	COG0252	asparaginase activity
O0R49_02850	COG2814	Major facilitator Superfamily
O0R49_02855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_02885	COG1309	transcriptional regulator
O0R49_02890	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O0R49_02895	COG1846	Transcriptional regulator
O0R49_02900	COG0778	Nitroreductase
O0R49_02915	COG1396	sequence-specific DNA binding
O0R49_02925	COG0456	acetyltransferase
O0R49_02935	COG4122	O-methyltransferase activity
O0R49_02945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O0R49_02950	COG0697	spore germination
O0R49_02960	COG1301	dicarboxylic acid transport
O0R49_03000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
O0R49_03005	COG0802	atpase or kinase
O0R49_03010	COG1214	PFAM Peptidase M22, glycoprotease
O0R49_03015	COG0456	acetyltransferase
O0R49_03020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O0R49_03025	COG0488	(ABC) transporter
O0R49_03030	COG0315	cyclic pyranopterin monophosphate synthase activity
O0R49_03035	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O0R49_03040	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O0R49_03045	COG0805	protein transport
O0R49_03050	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
O0R49_03060	COG1266	CAAX protease self-immunity
O0R49_03065	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O0R49_03070	COG0459	protein refolding
O0R49_03105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
O0R49_03110	COG0823	Involved in the tonB-independent uptake of proteins
O0R49_03120	COG2132	Multicopper oxidase
O0R49_03125	COG1113	amino acid transport
O0R49_03130	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O0R49_03135	COG0714	Associated with various cellular activities
O0R49_03140	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
O0R49_03145	COG1305	Transglutaminase-like
O0R49_03150	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O0R49_03150	COG0519	Catalyzes the synthesis of GMP from XMP
O0R49_03155	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
O0R49_03165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0R49_03170	COG2207	Transcriptional regulator
O0R49_03220	COG2814	Major facilitator Superfamily
O0R49_03225	COG0583	DNA-binding transcription factor activity
O0R49_03230	COG2252	PERMEase
O0R49_03245	COG3064	Membrane
O0R49_03250	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
O0R49_03260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
O0R49_03265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O0R49_03270	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O0R49_03275	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O0R49_03280	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O0R49_03285	COG0047	phosphoribosylformylglycinamidine synthase activity
O0R49_03290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O0R49_03295	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
O0R49_03300	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O0R49_03305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
O0R49_03310	COG0138	bifunctional purine biosynthesis protein purh
O0R49_03315	COG0151	Belongs to the GarS family
O0R49_03335	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O0R49_03340	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O0R49_03345	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O0R49_03350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0R49_03360	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O0R49_03365	COG4496	protein, YerC YecD
O0R49_03375	COG0069	glutamate synthase activity
O0R49_03390	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
O0R49_03395	COG0210	DNA helicase
O0R49_03400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O0R49_03405	COG4851	CamS sex pheromone cAM373 precursor
O0R49_03410	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O0R49_03415	COG1285	pathogenesis
O0R49_03420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R49_03425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O0R49_03430	COG0154	amidase activity
O0R49_03435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O0R49_03440	COG1309	transcriptional regulator
O0R49_03445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O0R49_03450	COG1957	nucleoside hydrolase
O0R49_03455	COG1597	lipid kinase activity
O0R49_03460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O0R49_03480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
O0R49_03490	COG1737	Transcriptional regulator
O0R49_03495	COG1263	PTS System
O0R49_03495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_03500	COG1486	melibiose metabolic process
O0R49_03510	COG1959	2 iron, 2 sulfur cluster binding
O0R49_03515	COG0492	ferredoxin-NADP+ reductase activity
O0R49_03530	COG1486	melibiose metabolic process
O0R49_03540	COG2211	Major facilitator Superfamily
O0R49_03570	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O0R49_03575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R49_03580	COG1442	glycosyl transferase family 8
O0R49_03585	COG1216	Glycosyl transferase, family 2
O0R49_03590	COG1442	glycosyl transferase family 8
O0R49_03595	COG2223	nitrite transmembrane transporter activity
O0R49_03605	COG0471	metal ion transport
O0R49_03620	COG0071	Belongs to the small heat shock protein (HSP20) family
O0R49_03635	COG0531	amino acid
O0R49_03640	COG0463	Glycosyl transferase, family 2
O0R49_03645	COG0488	(ABC) transporter
O0R49_03650	COG1469	GTP cyclohydrolase I activity
O0R49_03655	COG0789	Transcriptional regulator
O0R49_03660	COG2814	Major facilitator Superfamily
O0R49_03665	COG0488	(ABC) transporter
O0R49_03670	COG0513	Belongs to the DEAD box helicase family
O0R49_03675	COG2130	NADP-dependent
O0R49_03695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0R49_03695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0R49_03700	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O0R49_03710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0R49_03710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0R49_03720	COG3290	protein histidine kinase activity
O0R49_03725	COG4565	transcriptional regulatory protein
O0R49_03730	COG3181	Tripartite tricarboxylate transporter family receptor
O0R49_03735	COG2851	Citrate transporter
O0R49_03745	COG3479	Phenolic acid decarboxylase
O0R49_03750	COG1695	Transcriptional regulator
O0R49_03755	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
O0R49_03760	COG0477	Major facilitator Superfamily
O0R49_03765	COG0583	DNA-binding transcription factor activity
O0R49_03770	COG1254	Belongs to the acylphosphatase family
O0R49_03775	COG2258	MOSC domain
O0R49_03790	COG0024	Methionine aminopeptidase
O0R49_03795	COG1263	PTS System
O0R49_03795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_03800	COG3739	integral membrane protein
O0R49_03820	COG1368	sulfuric ester hydrolase activity
O0R49_03825	COG0076	glutamate decarboxylase activity
O0R49_03840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_03840	COG1263	PTS System
O0R49_03845	COG0366	Alpha amylase catalytic
O0R49_03850	COG2188	Transcriptional regulator
O0R49_03860	COG0737	Belongs to the 5'-nucleotidase family
O0R49_03865	COG0693	protein deglycase activity
O0R49_03870	COG4840	Belongs to the UPF0435 family
O0R49_03875	COG1115	amino acid carrier protein
O0R49_03880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0R49_03885	COG4980	gas vesicle protein
O0R49_03890	COG1295	ribonuclease BN
O0R49_03895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_03900	COG0477	Major facilitator Superfamily
O0R49_03910	COG0387	Pfam Sodium calcium exchanger
O0R49_03920	COG0217	transcriptional regulatory protein
O0R49_03925	COG0668	transmembrane transport
O0R49_03930	COG0535	radical SAM domain protein
O0R49_03940	COG0726	polysaccharide deacetylase
O0R49_03950	COG0598	Magnesium transport protein CorA
O0R49_03960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
O0R49_03965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
O0R49_03980	COG0789	Transcriptional regulator
O0R49_03985	COG2814	Major facilitator Superfamily
O0R49_04000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O0R49_04040	COG2076	Multidrug Resistance protein
O0R49_04045	COG2076	Multidrug Resistance protein
O0R49_04050	COG1309	transcriptional regulator
O0R49_04060	COG4637	Psort location Cytoplasmic, score
O0R49_04065	COG2755	lipolytic protein G-D-S-L family
O0R49_04070	COG0492	ferredoxin-NADP+ reductase activity
O0R49_04075	COG2169	Transcriptional regulator
O0R49_04080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_04085	COG1132	(ABC) transporter
O0R49_04090	COG1742	UPF0060 membrane protein
O0R49_04095	COG1595	DNA-templated transcription, initiation
O0R49_04115	COG2318	DinB family
O0R49_04125	COG1846	Transcriptional regulator
O0R49_04130	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O0R49_04130	COG0392	lysyltransferase activity
O0R49_04150	COG0778	Nitroreductase
O0R49_04165	COG1090	epimerase
O0R49_04170	COG2137	regulation of response to DNA damage stimulus
O0R49_04195	COG0463	Glycosyl transferase, family 2
O0R49_04200	COG4485	Bacterial membrane protein, YfhO
O0R49_04205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O0R49_04220	COG2140	Oxalate decarboxylase
O0R49_04230	COG1191	sigma factor activity
O0R49_04240	COG1988	membrane-bound metal-dependent
O0R49_04245	COG1194	a g-specific adenine glycosylase
O0R49_04255	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_04270	COG3557	Belongs to the UPF0374 family
O0R49_04275	COG1132	(ABC) transporter
O0R49_04280	COG0444	Belongs to the ABC transporter superfamily
O0R49_04285	COG4608	Belongs to the ABC transporter superfamily
O0R49_04290	COG0747	negative chemotaxis
O0R49_04295	COG0601	transmembrane transport
O0R49_04300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R49_04305	COG4129	membrane
O0R49_04310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O0R49_04315	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O0R49_04320	COG0735	belongs to the Fur family
O0R49_04470	COG1368	sulfuric ester hydrolase activity
O0R49_04475	COG0681	Belongs to the peptidase S26 family
O0R49_04480	COG2873	o-acetylhomoserine
O0R49_04490	COG1116	anion transmembrane transporter activity
O0R49_04495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O0R49_04500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O0R49_04515	COG1131	(ABC) transporter
O0R49_04545	COG3382	B3 4 domain protein
O0R49_04550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
O0R49_04560	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O0R49_04565	COG2766	serine protein kinase
O0R49_04570	COG2718	Belongs to the UPF0229 family
O0R49_04575	COG1566	PFAM secretion protein HlyD family protein
O0R49_04580	COG2814	Major facilitator Superfamily
O0R49_04585	COG0655	NAD(P)H dehydrogenase (quinone) activity
O0R49_04595	COG1278	Cold shock
O0R49_04600	COG3706	GGDEF domain
O0R49_04625	COG5577	PFAM Coat F domain
O0R49_04630	COG5002	protein histidine kinase activity
O0R49_04635	COG0737	Belongs to the 5'-nucleotidase family
O0R49_04635	COG1525	nuclease
O0R49_04635	COG4085	toxin activity
O0R49_04640	COG3764	Sortase (surface protein transpeptidase)
O0R49_04645	COG0564	pseudouridine synthase activity
O0R49_04655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
O0R49_04660	COG3153	acetyltransferase
O0R49_04660	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O0R49_04675	COG3835	regulator
O0R49_04680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O0R49_04685	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
O0R49_04690	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O0R49_04695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O0R49_04700	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O0R49_04705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O0R49_04710	COG2203	Gaf domain
O0R49_04710	COG4585	Histidine kinase
O0R49_04715	COG2197	response regulator
O0R49_04730	COG0753	catalase activity
O0R49_04735	COG1959	2 iron, 2 sulfur cluster binding
O0R49_04740	COG1017	nitric oxide dioxygenase activity
O0R49_04740	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O0R49_04745	COG2719	SpoVR family
O0R49_04750	COG1785	Belongs to the alkaline phosphatase family
O0R49_04755	COG0791	NLP P60 protein
O0R49_04755	COG1388	LysM domain
O0R49_04760	COG0531	amino acid
O0R49_04775	COG1595	DNA-templated transcription, initiation
O0R49_04780	COG0204	Acyl-transferase
O0R49_04785	COG1253	flavin adenine dinucleotide binding
O0R49_04790	COG0789	Transcriptional regulator
O0R49_04795	COG1253	flavin adenine dinucleotide binding
O0R49_04805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O0R49_04810	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O0R49_04815	COG0584	glycerophosphoryl diester phosphodiesterase
O0R49_04825	COG0668	transmembrane transport
O0R49_04830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
O0R49_04835	COG0726	polysaccharide deacetylase
O0R49_04840	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R49_04845	COG0589	response to stress
O0R49_04850	COG1132	(ABC) transporter
O0R49_04855	COG1132	(ABC) transporter
O0R49_04860	COG0702	epimerase
O0R49_04870	COG3842	ATPase activity
O0R49_04875	COG2508	Transcriptional regulator
O0R49_04885	COG0189	ligase activity
O0R49_04890	COG0189	ligase activity
O0R49_04895	COG4399	Belongs to the UPF0754 family
O0R49_04900	COG3679	Belongs to the UPF0342 family
O0R49_04905	COG0561	phosphatase activity
O0R49_04910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O0R49_04920	COG0475	glutathione-regulated potassium exporter activity
O0R49_04925	COG0490	domain, Protein
O0R49_04935	COG1024	Enoyl-CoA hydratase
O0R49_04945	COG0420	3'-5' exonuclease activity
O0R49_04950	COG4717	serine-type aminopeptidase activity
O0R49_04955	COG3481	metal-dependent phosphohydrolase, HD sub domain
O0R49_04965	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
O0R49_04995	COG1846	Transcriptional regulator
O0R49_05000	COG4980	gas vesicle protein
O0R49_05015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O0R49_05020	COG0537	adenosine 5'-monophosphoramidase activity
O0R49_05025	COG1131	(ABC) transporter
O0R49_05030	COG4473	ABC transporter
O0R49_05040	COG1473	amidohydrolase
O0R49_05050	COG2329	Antibiotic biosynthesis monooxygenase
O0R49_05055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R49_05060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O0R49_05065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O0R49_05070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
O0R49_05075	COG1309	transcriptional regulator
O0R49_05080	COG1511	domain protein
O0R49_05085	COG1363	Peptidase, m42
O0R49_05090	COG1301	dicarboxylic acid transport
O0R49_05100	COG1234	tRNA 3'-trailer cleavage
O0R49_05105	COG0095	Lipoate-protein ligase
O0R49_05110	COG0318	PFAM AMP-dependent synthetase and ligase
O0R49_05120	COG0501	Belongs to the peptidase M48B family
O0R49_05125	COG1404	Belongs to the peptidase S8 family
O0R49_05130	COG0406	alpha-ribazole phosphatase activity
O0R49_05135	COG0840	transmembrane signaling receptor activity
O0R49_05140	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O0R49_05140	COG0723	plastoquinol--plastocyanin reductase activity
O0R49_05145	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_05165	COG2856	Zn peptidase
O0R49_05175	COG1396	sequence-specific DNA binding
O0R49_05230	COG3935	DnaD domain protein
O0R49_05235	COG1484	DNA-dependent DNA replication
O0R49_05285	COG3677	Transposase
O0R49_05295	COG5484	DNA packaging
O0R49_05410	COG4824	toxin secretion phage lysis holin
O0R49_05415	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R49_05415	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_05455	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R49_05460	COG2814	Major facilitator Superfamily
O0R49_05465	COG2732	(Barnase) inhibitor
O0R49_05470	COG1316	TRANSCRIPTIONal
O0R49_05480	COG0398	Pfam SNARE associated Golgi protein
O0R49_05485	COG0681	Belongs to the peptidase S26 family
O0R49_05490	COG3180	Ammonia monooxygenase
O0R49_05500	COG0501	Belongs to the peptidase M48B family
O0R49_05505	COG2259	Doxx family
O0R49_05510	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
O0R49_05515	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O0R49_05520	COG1074	ATP-dependent DNA helicase activity
O0R49_05525	COG0420	3'-5' exonuclease activity
O0R49_05530	COG0419	ATPase involved in DNA repair
O0R49_05535	COG1403	HNH endonuclease
O0R49_05575	COG5337	Spore coat protein CotH
O0R49_05585	COG0179	Fumarylacetoacetate (FAA) hydrolase
O0R49_05600	COG0367	asparagine synthase
O0R49_05615	COG1562	ergosterol biosynthetic process
O0R49_05620	COG0534	Mate efflux family protein
O0R49_05625	COG1917	Cupin 2, conserved barrel domain protein
O0R49_05625	COG2207	Transcriptional regulator
O0R49_05655	COG0076	glutamate decarboxylase activity
O0R49_05690	COG1410	methionine synthase
O0R49_05690	COG0646	methionine synthase
O0R49_05695	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
O0R49_05695	COG0646	methionine synthase
O0R49_05700	COG1666	GTP binding
O0R49_05705	COG2996	Protein conserved in bacteria
O0R49_05710	COG1744	ABC transporter substrate-binding protein PnrA-like
O0R49_05715	COG0840	transmembrane signaling receptor activity
O0R49_05720	COG1307	EDD domain protein, DegV family
O0R49_05725	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R49_05745	COG0561	phosphatase activity
O0R49_05750	COG1073	alpha beta
O0R49_05755	COG2151	metal-sulfur cluster biosynthetic enzyme
O0R49_05760	COG0277	FAD linked oxidase domain protein
O0R49_05765	COG2271	Major facilitator Superfamily
O0R49_05770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O0R49_05775	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O0R49_05780	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O0R49_05785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O0R49_05790	COG0505	Belongs to the CarA family
O0R49_05795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O0R49_05800	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O0R49_05810	COG2814	Major facilitator Superfamily
O0R49_05820	COG2267	carboxylic ester hydrolase activity
O0R49_05830	COG1744	ABC transporter substrate-binding protein PnrA-like
O0R49_05845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O0R49_05850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O0R49_05855	COG5504	Zn-dependent protease
O0R49_05860	COG0444	Belongs to the ABC transporter superfamily
O0R49_05865	COG4608	Belongs to the ABC transporter superfamily
O0R49_05875	COG0601	transmembrane transport
O0R49_05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R49_05890	COG0180	Tryptophanyl-tRNA synthetase
O0R49_05895	COG4166	transmembrane transport
O0R49_05900	COG0601	transmembrane transport
O0R49_05905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R49_05910	COG0444	Belongs to the ABC transporter superfamily
O0R49_05915	COG4608	Belongs to the ABC transporter superfamily
O0R49_05925	COG0456	acetyltransferase
O0R49_05930	COG1393	Belongs to the ArsC family
O0R49_05935	COG0861	Integral membrane protein TerC family
O0R49_05940	COG4862	establishment of competence for transformation
O0R49_05945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R49_05955	COG1164	Oligoendopeptidase f
O0R49_05965	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O0R49_05970	COG2346	COG2346, Truncated hemoglobins
O0R49_05975	COG0741	lytic transglycosylase activity
O0R49_05980	COG4116	CYTH
O0R49_05990	COG2357	RelA SpoT domain protein
O0R49_05995	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O0R49_06000	COG0564	pseudouridine synthase activity
O0R49_06005	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O0R49_06010	COG0475	glutathione-regulated potassium exporter activity
O0R49_06010	COG0569	domain protein
O0R49_06015	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O0R49_06020	COG0352	thiamine-phosphate diphosphorylase activity
O0R49_06030	COG2104	thiamine diphosphate biosynthetic process
O0R49_06035	COG2022	thiamine diphosphate biosynthetic process
O0R49_06040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O0R49_06045	COG0351	phosphomethylpyrimidine kinase
O0R49_06050	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
O0R49_06110	COG0210	DNA helicase
O0R49_06125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O0R49_06130	COG2382	esterase
O0R49_06135	COG0626	cystathionine gamma-synthase activity
O0R49_06140	COG0626	cystathionine gamma-synthase activity
O0R49_06185	COG0825	malonyl-CoA metabolic process
O0R49_06195	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R49_06210	COG2807	transmembrane transport
O0R49_06220	COG0583	DNA-binding transcription factor activity
O0R49_06235	COG0457	Tetratricopeptide repeat
O0R49_06245	COG5444	nuclease activity
O0R49_06270	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
O0R49_06280	COG0583	DNA-binding transcription factor activity
O0R49_06300	COG0583	DNA-binding transcription factor activity
O0R49_06305	COG2807	transmembrane transport
O0R49_06325	COG0457	Tetratricopeptide repeat
O0R49_06350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O0R49_06370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R49_06375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R49_06380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R49_06385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O0R49_06400	COG4195	phage-related replication protein
O0R49_06405	COG2856	Zn peptidase
O0R49_06410	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_06410	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R49_06430	COG0306	phosphate transporter
O0R49_06435	COG1392	Phosphate transport regulator
O0R49_06445	COG0405	Gamma-glutamyltransferase
O0R49_06450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
O0R49_06460	COG4208	sulfate ABC transporter
O0R49_06465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
O0R49_06475	COG3775	system Galactitol-specific IIC component
O0R49_06490	COG1063	alcohol dehydrogenase
O0R49_06495	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R49_06500	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R49_06500	COG0022	dehydrogenase e1 component
O0R49_06505	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R49_06510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R49_06515	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_06520	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_06525	COG2390	Transcriptional regulator
O0R49_06535	COG0531	amino acid
O0R49_06540	COG0346	lactoylglutathione lyase activity
O0R49_06545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R49_06550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0R49_06555	COG2362	D-Aminopeptidase
O0R49_06560	COG0601	transmembrane transport
O0R49_06565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R49_06570	COG0444	Belongs to the ABC transporter superfamily
O0R49_06575	COG4166	transmembrane transport
O0R49_06580	COG1619	proteins homologs of microcin C7 resistance protein MccF
O0R49_06585	COG4948	Mandelate Racemase Muconate Lactonizing
O0R49_06590	COG0791	NLP P60 protein
O0R49_06595	COG4608	Belongs to the ABC transporter superfamily
O0R49_06600	COG1834	amidinotransferase
O0R49_06605	COG1607	acyl-coa hydrolase
O0R49_06610	COG1695	Transcriptional regulator
O0R49_06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_06640	COG2076	Multidrug Resistance protein
O0R49_06645	COG2076	Multidrug Resistance protein
O0R49_06655	COG0788	formyltetrahydrofolate deformylase activity
O0R49_06660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O0R49_06665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O0R49_06670	COG0457	Tetratricopeptide repeat
O0R49_06680	COG1764	response to oxidative stress
O0R49_06685	COG1846	Transcriptional regulator
O0R49_06690	COG1764	response to oxidative stress
O0R49_06695	COG0590	tRNA wobble adenosine to inosine editing
O0R49_06700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O0R49_06705	COG1404	Belongs to the peptidase S8 family
O0R49_06720	COG0745	RESPONSE REGULATOR receiver
O0R49_06725	COG3850	Histidine kinase
O0R49_06725	COG5002	protein histidine kinase activity
O0R49_06730	COG3212	peptidase
O0R49_06735	COG3212	peptidase
O0R49_06745	COG2239	Acts as a magnesium transporter
O0R49_06755	COG0583	DNA-binding transcription factor activity
O0R49_06765	COG0789	Transcriptional regulator
O0R49_06780	COG1846	Transcriptional regulator
O0R49_06785	COG3300	MHYT domain
O0R49_06785	COG5001	Diguanylate cyclase
O0R49_06790	COG0586	Pfam SNARE associated Golgi protein
O0R49_06800	COG1191	sigma factor activity
O0R49_06820	COG0501	Belongs to the peptidase M48B family
O0R49_06825	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
O0R49_06830	COG2323	membrane
O0R49_06845	COG3594	Acyltransferase
O0R49_06850	COG5002	protein histidine kinase activity
O0R49_06855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O0R49_06865	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O0R49_06870	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
O0R49_06875	COG0436	Aminotransferase
O0R49_06880	COG1850	ribulose-bisphosphate carboxylase activity
O0R49_06885	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
O0R49_06890	COG0235	Class ii aldolase
O0R49_06895	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
O0R49_06905	COG3852	Histidine kinase
O0R49_06910	COG1846	Transcriptional regulator
O0R49_06915	COG1360	Flagellar Motor Protein
O0R49_06920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
O0R49_06925	COG0542	response to heat
O0R49_06930	COG3949	Membrane
O0R49_06935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
O0R49_06940	COG0720	synthase
O0R49_06945	COG0602	queuosine metabolic process
O0R49_06950	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
O0R49_06960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_06965	COG4873	Protein conserved in bacteria
O0R49_06975	COG3773	Cell wall hydrolase
O0R49_06990	COG0457	Tetratricopeptide repeat
O0R49_07000	COG2244	polysaccharide biosynthetic process
O0R49_07005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_07010	COG2217	Heavy metal translocating P-type atpase
O0R49_07015	COG0006	proline dipeptidase activity
O0R49_07025	COG1609	Transcriptional regulator
O0R49_07030	COG3711	transcriptional antiterminator
O0R49_07035	COG1263	PTS System
O0R49_07035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_07035	COG2190	(PTS) system
O0R49_07040	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_07045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O0R49_07055	COG1533	DNA photolyase activity
O0R49_07060	COG0840	transmembrane signaling receptor activity
O0R49_07070	COG2084	Dehydrogenase
O0R49_07075	COG2340	Cysteine-rich secretory protein family
O0R49_07080	COG0768	penicillin binding
O0R49_07085	COG4191	Histidine kinase
O0R49_07090	COG0436	Aminotransferase
O0R49_07095	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
O0R49_07105	COG1714	RDD family
O0R49_07115	COG0835	chemotaxis
O0R49_07115	COG0784	Response regulator, receiver
O0R49_07140	COG2814	Major facilitator Superfamily
O0R49_07145	COG1376	ErfK ybiS ycfS ynhG family protein
O0R49_07150	COG1408	metallophosphoesterase
O0R49_07155	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_07160	COG2200	EAL domain
O0R49_07165	COG3546	catalase activity
O0R49_07170	COG4703	Protein of unknown function (DUF1797)
O0R49_07175	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
O0R49_07185	COG0517	IMP dehydrogenase activity
O0R49_07190	COG0583	DNA-binding transcription factor activity
O0R49_07195	COG0716	FMN binding
O0R49_07205	COG0716	FMN binding
O0R49_07210	COG2171	N-acyltransferase activity
O0R49_07215	COG1473	amidohydrolase
O0R49_07225	COG0668	transmembrane transport
O0R49_07230	COG0450	alkyl hydroperoxide reductase
O0R49_07235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_07250	COG0746	molybdenum cofactor guanylyltransferase activity
O0R49_07255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
O0R49_07260	COG0303	'Molybdopterin
O0R49_07265	COG1763	Mo-molybdopterin cofactor biosynthetic process
O0R49_07270	COG0314	molybdopterin synthase activity
O0R49_07275	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
O0R49_07290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
O0R49_07295	COG1136	(ABC) transporter
O0R49_07300	COG0577	efflux transmembrane transporter activity
O0R49_07305	COG1349	DNA-binding transcription factor activity
O0R49_07310	COG1105	Belongs to the carbohydrate kinase PfkB family
O0R49_07315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_07315	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_07315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_07330	COG0488	(ABC) transporter
O0R49_07335	COG2309	aminopeptidase activity
O0R49_07345	COG1077	Cell shape determining protein MreB Mrl
O0R49_07350	COG2002	toxin-antitoxin pair type II binding
O0R49_07355	COG3852	Histidine kinase
O0R49_07360	COG2105	PFAM AIG2 family protein
O0R49_07360	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
O0R49_07365	COG0569	domain protein
O0R49_07370	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
O0R49_07375	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O0R49_07380	COG5503	Protein of unknown function (DUF1447)
O0R49_07385	COG0561	phosphatase activity
O0R49_07390	COG0242	peptide deformylase activity
O0R49_07405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R49_07410	COG0022	dehydrogenase e1 component
O0R49_07415	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R49_07420	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R49_07425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_07435	COG1982	Orn Lys Arg decarboxylase major
O0R49_07440	COG4476	Belongs to the UPF0223 family
O0R49_07445	COG4493	Belongs to the UPF0637 family
O0R49_07455	COG0483	inositol monophosphate 1-phosphatase activity
O0R49_07470	COG1595	DNA-templated transcription, initiation
O0R49_07490	COG1217	gtp-binding protein TYPA
O0R49_07500	COG4896	Protein conserved in bacteria
O0R49_07510	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O0R49_07515	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
O0R49_07520	COG2066	Belongs to the glutaminase family
O0R49_07525	COG4838	Belongs to the UPF0358 family
O0R49_07530	COG0772	Belongs to the SEDS family
O0R49_07535	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O0R49_07540	COG0415	Belongs to the DNA photolyase family
O0R49_07545	COG1612	heme a metabolic process
O0R49_07550	COG0109	protoheme IX farnesyltransferase activity
O0R49_07555	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O0R49_07555	COG2010	Cytochrome c
O0R49_07560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O0R49_07565	COG1845	cytochrome c oxidase, subunit III
O0R49_07570	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O0R49_07575	COG3336	cytochrome c oxidase
O0R49_07585	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O0R49_07590	COG2340	Cysteine-rich secretory protein family
O0R49_07610	COG3679	Belongs to the UPF0342 family
O0R49_07615	COG4471	UPF0298 protein
O0R49_07620	COG0742	ribosomal rna small subunit methyltransferase
O0R49_07625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O0R49_07630	COG3314	Sporulation integral membrane protein YlbJ
O0R49_07635	COG1752	Esterase of the alpha-beta hydrolase superfamily
O0R49_07640	COG3480	Lon protease (S16) C-terminal proteolytic domain
O0R49_07650	COG1399	metal-binding, possibly nucleic acid-binding protein
O0R49_07655	COG0333	Belongs to the bacterial ribosomal protein bL32 family
O0R49_07665	COG0454	-acetyltransferase
O0R49_07670	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
O0R49_07675	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
O0R49_07680	COG2001	Belongs to the MraZ family
O0R49_07685	COG0275	rRNA processing
O0R49_07690	COG4839	cell division protein FtsL
O0R49_07695	COG0768	penicillin binding
O0R49_07700	COG0768	penicillin binding
O0R49_07710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O0R49_07715	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O0R49_07720	COG0772	Belongs to the SEDS family
O0R49_07725	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O0R49_07730	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O0R49_07735	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O0R49_07740	COG3879	Bacterial protein of unknown function (DUF881)
O0R49_07745	COG3879	Bacterial protein of unknown function (DUF881)
O0R49_07750	COG3856	small basic protein
O0R49_07755	COG0849	cell division
O0R49_07760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O0R49_07765	COG1404	Belongs to the peptidase S8 family
O0R49_07765	COG4412	M6 family metalloprotease domain protein
O0R49_07775	COG1191	sigma factor activity
O0R49_07780	COG1191	sigma factor activity
O0R49_07785	COG2390	Transcriptional regulator
O0R49_07800	COG3730	PTS system glucitol sorbitol-specific
O0R49_07805	COG3732	PTS system glucitol sorbitol-specific
O0R49_07815	COG1119	ATPase activity
O0R49_07820	COG1873	PFAM PRC-barrel domain
O0R49_07825	COG1496	oxidoreductase activity
O0R49_07830	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
O0R49_07835	COG1799	cell septum assembly
O0R49_07840	COG0762	integral membrane protein
O0R49_07845	COG2302	S4 RNA-binding domain
O0R49_07850	COG3599	regulation of cell shape
O0R49_07855	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O0R49_07860	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O0R49_07865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O0R49_07870	COG0564	pseudouridine synthase activity
O0R49_07875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O0R49_07880	COG2233	PERMEase
O0R49_07885	COG0540	Belongs to the ATCase OTCase family
O0R49_07890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O0R49_07895	COG0505	Belongs to the CarA family
O0R49_07900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
O0R49_07905	COG0543	2 iron, 2 sulfur cluster binding
O0R49_07910	COG0167	dihydroorotate dehydrogenase activity
O0R49_07915	COG0284	orotidine-5'-phosphate decarboxylase activity
O0R49_07920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
O0R49_07930	COG0175	sulfate reduction
O0R49_07935	COG0306	phosphate transporter
O0R49_07940	COG2046	Belongs to the sulfate adenylyltransferase family
O0R49_07945	COG0529	Catalyzes the synthesis of activated sulfate
O0R49_07950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O0R49_07955	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
O0R49_07960	COG1648	precorrin-2 dehydrogenase activity
O0R49_07970	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O0R49_07975	COG1561	YicC-like family, N-terminal region
O0R49_07980	COG2052	Domain of unknown function (DUF370)
O0R49_07985	COG0194	GDP metabolic process
O0R49_07990	COG1758	RNA polymerase activity
O0R49_07995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O0R49_08000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
O0R49_08005	COG0242	peptide deformylase activity
O0R49_08010	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O0R49_08015	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
O0R49_08015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O0R49_08020	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O0R49_08025	COG0631	protein serine/threonine phosphatase activity
O0R49_08030	COG2815	serine threonine protein kinase
O0R49_08030	COG0515	serine threonine protein kinase
O0R49_08035	COG1162	GTPase activity
O0R49_08040	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O0R49_08045	COG1564	THIamine pyrophosphokinase
O0R49_08055	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O0R49_08060	COG1302	Protein conserved in bacteria
O0R49_08065	COG1461	Dihydroxyacetone kinase
O0R49_08070	COG1760	l-serine dehydratase
O0R49_08075	COG1760	l-serine dehydratase
O0R49_08080	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O0R49_08085	COG1349	DNA-binding transcription factor activity
O0R49_08090	COG0416	fatty acid biosynthetic process
O0R49_08095	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O0R49_08100	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_08105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R49_08115	COG1196	nuclear chromosome segregation
O0R49_08120	COG0552	protein localization to endoplasmic reticulum
O0R49_08125	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
O0R49_08130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
O0R49_08135	COG0228	four-way junction DNA binding
O0R49_08140	COG1837	Belongs to the UPF0109 family
O0R49_08150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O0R49_08155	COG0336	Belongs to the RNA methyltransferase TrmD family
O0R49_08160	COG0335	large ribosomal subunit rRNA binding
O0R49_08165	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O0R49_08170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O0R49_08180	COG2257	FlhB HrpN YscU SpaS Family
O0R49_08185	COG0045	succinate-CoA ligase (ADP-forming) activity
O0R49_08190	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
O0R49_08195	COG0758	DNA mediated transformation
O0R49_08200	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O0R49_08205	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
O0R49_08210	COG4974	Belongs to the 'phage' integrase family
O0R49_08215	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
O0R49_08220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
O0R49_08225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O0R49_08230	COG1815	bacterial-type flagellum-dependent cell motility
O0R49_08235	COG1558	bacterial-type flagellum-dependent cell motility
O0R49_08240	COG1677	Flagellar hook-basal body complex protein FliE
O0R49_08245	COG1766	The M ring may be actively involved in energy transduction
O0R49_08250	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0R49_08255	COG1317	bacterial-type flagellum organization
O0R49_08260	COG1157	protein secretion by the type III secretion system
O0R49_08265	COG2882	bacterial-type flagellum organization
O0R49_08270	COG3334	PFAM MgtE intracellular
O0R49_08275	COG3144	bacterial-type flagellum assembly
O0R49_08280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
O0R49_08285	COG4786	Flagellar basal body rod
O0R49_08290	COG1582	Flagellar protein (FlbD)
O0R49_08295	COG1580	Controls the rotational direction of flagella during chemotaxis
O0R49_08300	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0R49_08305	COG1776	CheC inhibitor of MCP methylation
O0R49_08305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
O0R49_08310	COG2201	protein-glutamate methylesterase activity
O0R49_08315	COG3190	flagellar
O0R49_08320	COG1338	Plays a role in the flagellum-specific transport system
O0R49_08325	COG1987	bacterial-type flagellum assembly
O0R49_08330	COG1684	flagellar biosynthetic protein fliR
O0R49_08335	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0R49_08340	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
O0R49_08345	COG1419	protein localization to endoplasmic reticulum
O0R49_08350	COG0455	bacterial-type flagellum organization
O0R49_08355	COG2201	protein-glutamate methylesterase activity
O0R49_08360	COG0643	Histidine kinase
O0R49_08360	COG2198	Histidine kinase
O0R49_08365	COG0835	chemotaxis
O0R49_08370	COG1776	CheC inhibitor of MCP methylation
O0R49_08375	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
O0R49_08380	COG1191	sigma factor activity
O0R49_08395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O0R49_08400	COG0528	UMP kinase activity
O0R49_08405	COG0233	cytoplasmic translational termination
O0R49_08410	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O0R49_08415	COG4589	Belongs to the CDS family
O0R49_08420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O0R49_08425	COG0750	zinc metalloprotease
O0R49_08430	COG0442	prolyl-tRNA aminoacylation
O0R49_08435	COG2176	DNA-directed DNA polymerase activity
O0R49_08450	COG3693	PFAM glycoside hydrolase, family 10
O0R49_08470	COG1131	(ABC) transporter
O0R49_08520	COG0779	Required for maturation of 30S ribosomal subunits
O0R49_08525	COG0195	Participates in both transcription termination and antitermination
O0R49_08530	COG2740	Nucleic-acid-binding protein implicated in transcription termination
O0R49_08535	COG1358	cellular component organization or biogenesis
O0R49_08540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O0R49_08545	COG1550	Protein conserved in bacteria
O0R49_08550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O0R49_08555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O0R49_08560	COG0196	riboflavin kinase activity
O0R49_08565	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O0R49_08570	COG1185	polyribonucleotide nucleotidyltransferase activity
O0R49_08575	COG0726	polysaccharide deacetylase
O0R49_08580	COG0612	Peptidase, M16
O0R49_08585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R49_08595	COG1132	(ABC) transporter
O0R49_08600	COG1132	(ABC) transporter
O0R49_08635	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
O0R49_08655	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_08660	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_08665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O0R49_08670	COG1260	myo-inositol-1-phosphate synthase
O0R49_08715	COG0367	asparagine synthase
O0R49_08720	COG1873	PFAM PRC-barrel domain
O0R49_08725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0R49_08730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
O0R49_08735	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
O0R49_08740	COG0527	aspartate kinase activity
O0R49_08750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O0R49_08755	COG0740	serine-type endopeptidase activity
O0R49_08765	COG4980	gas vesicle protein
O0R49_08765	COG1674	ftsk spoiiie
O0R49_08770	COG2188	Transcriptional regulator
O0R49_08775	COG2814	Major facilitator Superfamily
O0R49_08780	COG1033	growth of symbiont in host cell
O0R49_08780	COG2409	Drug exporters of the RND superfamily
O0R49_08785	COG0612	Peptidase, M16
O0R49_08790	COG0612	Peptidase, M16
O0R49_08800	COG1033	growth of symbiont in host cell
O0R49_08800	COG2409	Drug exporters of the RND superfamily
O0R49_08805	COG0300	oxidoreductase activity
O0R49_08820	COG1426	Protein conserved in bacteria
O0R49_08825	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
O0R49_08830	COG1546	Belongs to the CinA family
O0R49_08830	COG1058	Belongs to the CinA family
O0R49_08835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O0R49_08840	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O0R49_08845	COG1418	mRNA catabolic process
O0R49_08850	COG1692	metallophosphoesterase
O0R49_08855	COG2359	stage V sporulation protein S
O0R49_08860	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O0R49_08865	COG1063	alcohol dehydrogenase
O0R49_08870	COG0156	8-amino-7-oxononanoate synthase activity
O0R49_08875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0R49_08880	COG4550	Control of competence regulator ComK, YlbF/YmcA
O0R49_08890	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
O0R49_08895	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O0R49_08910	COG1329	Transcriptional regulator
O0R49_08915	COG4195	phage-related replication protein
O0R49_08920	COG0457	Tetratricopeptide repeat
O0R49_08925	COG1404	Belongs to the peptidase S8 family
O0R49_08930	COG4195	phage-related replication protein
O0R49_08935	COG1764	response to oxidative stress
O0R49_08940	COG2076	Multidrug Resistance protein
O0R49_08965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O0R49_08970	COG1923	regulation of RNA biosynthetic process
O0R49_08985	COG1780	Probably involved in ribonucleotide reductase function
O0R49_08990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0R49_08995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O0R49_09000	COG4112	unkown
O0R49_09005	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_09010	COG0464	growth
O0R49_09015	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O0R49_09020	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
O0R49_09025	COG0789	Transcriptional regulator
O0R49_09030	COG0174	glutamine synthetase
O0R49_09040	COG4282	regulation of fungal-type cell wall biogenesis
O0R49_09070	COG1783	phage Terminase large subunit
O0R49_09110	COG0457	Tetratricopeptide repeat
O0R49_09120	COG5444	nuclease activity
O0R49_09145	COG5646	InterPro IPR014922
O0R49_09150	COG0457	Tetratricopeptide repeat
O0R49_09160	COG3619	membrane
O0R49_09165	COG1793	dna ligase
O0R49_09165	COG3285	dna ligase
O0R49_09170	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O0R49_09175	COG4876	unkown
O0R49_09180	COG0346	lactoylglutathione lyase activity
O0R49_09185	COG1959	2 iron, 2 sulfur cluster binding
O0R49_09190	COG0702	epimerase
O0R49_09195	COG0247	lactate metabolic process
O0R49_09200	COG1139	Iron-sulfur cluster binding protein
O0R49_09205	COG1556	Lactate utilization protein
O0R49_09225	COG2323	membrane
O0R49_09230	COG1309	transcriptional regulator
O0R49_09235	COG2124	cytochrome p450
O0R49_09235	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O0R49_09240	COG3591	Belongs to the peptidase S1B family
O0R49_09245	COG3209	COG3209 Rhs family protein
O0R49_09250	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_09265	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O0R49_09270	COG1388	LysM domain
O0R49_09275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
O0R49_09280	COG4224	UPF0291 protein
O0R49_09285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
O0R49_09295	COG3763	UPF0154 protein
O0R49_09305	COG0785	Cytochrome C biogenesis protein
O0R49_09310	COG4846	Membrane protein involved in cytochrome C biogenesis
O0R49_09320	COG0071	Belongs to the small heat shock protein (HSP20) family
O0R49_09335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O0R49_09340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_09360	COG0824	Thioesterase
O0R49_09370	COG4841	protein insertion into membrane
O0R49_09375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
O0R49_09385	COG1832	CoA-binding protein
O0R49_09390	COG0187	DNA topoisomerase II activity
O0R49_09395	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O0R49_09410	COG0738	Major facilitator superfamily
O0R49_09420	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_09425	COG1312	Catalyzes the dehydration of D-mannonate
O0R49_09430	COG1802	Transcriptional regulator
O0R49_09435	COG0673	inositol 2-dehydrogenase activity
O0R49_09445	COG1904	glucuronate isomerase
O0R49_09450	COG2249	NAD(P)H dehydrogenase (quinone) activity
O0R49_09455	COG1733	regulation of RNA biosynthetic process
O0R49_09465	COG2197	response regulator
O0R49_09470	COG4585	Histidine kinase
O0R49_09475	COG2409	Drug exporters of the RND superfamily
O0R49_09480	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R49_09485	COG0251	oxidation-reduction process
O0R49_09525	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O0R49_09540	COG0583	DNA-binding transcription factor activity
O0R49_09565	COG0657	acetylesterase activity
O0R49_09570	COG0789	Transcriptional regulator
O0R49_09580	COG2205	protein histidine kinase activity
O0R49_09585	COG0745	RESPONSE REGULATOR receiver
O0R49_09595	COG3507	Belongs to the glycosyl hydrolase 43 family
O0R49_09600	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_09605	COG1486	melibiose metabolic process
O0R49_09610	COG0395	ABC-type sugar transport system, permease component
O0R49_09615	COG1175	transmembrane transport
O0R49_09620	COG1653	transport
O0R49_09625	COG1609	Transcriptional regulator
O0R49_09630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
O0R49_09645	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_09655	COG0456	acetyltransferase
O0R49_09660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R49_09695	COG5444	nuclease activity
O0R49_09715	COG1846	Transcriptional regulator
O0R49_09720	COG2814	Major facilitator Superfamily
O0R49_09730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_09730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_09730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_09735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_09735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O0R49_09735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_09740	COG1105	Belongs to the carbohydrate kinase PfkB family
O0R49_09750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R49_09780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O0R49_09785	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0R49_09790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O0R49_09795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O0R49_09800	COG1024	Enoyl-CoA hydratase
O0R49_09805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0R49_09810	COG0511	ligase activity, forming carbon-carbon bonds
O0R49_09815	COG0439	Biotin carboxylase
O0R49_09820	COG0318	PFAM AMP-dependent synthetase and ligase
O0R49_09825	COG1960	acyl-CoA dehydrogenase activity
O0R49_09830	COG1649	PFAM Uncharacterised BCR, COG1649
O0R49_09835	COG2365	Tyrosine phosphatase family
O0R49_09840	COG1349	DNA-binding transcription factor activity
O0R49_09850	COG3835	regulator
O0R49_09855	COG0277	FAD linked oxidase domain protein
O0R49_09860	COG0247	lactate metabolic process
O0R49_09890	COG0166	Belongs to the GPI family
O0R49_09895	COG2246	polysaccharide biosynthetic process
O0R49_09900	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O0R49_09905	COG0586	Pfam SNARE associated Golgi protein
O0R49_09910	COG1587	Uroporphyrinogen-III synthase
O0R49_09920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_09935	COG0534	Mate efflux family protein
O0R49_09940	COG2027	D-alanyl-D-alanine carboxypeptidase
O0R49_09945	COG4677	pectinesterase activity
O0R49_09950	COG2323	membrane
O0R49_09955	COG2146	nitrite reductase [NAD(P)H] activity
O0R49_09960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0R49_09965	COG0243	molybdopterin cofactor binding
O0R49_09970	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O0R49_09975	COG2223	nitrite transmembrane transporter activity
O0R49_09980	COG0493	'glutamate synthase
O0R49_09985	COG0070	glutamate synthase
O0R49_09985	COG0067	glutamate synthase
O0R49_09985	COG0069	glutamate synthase activity
O0R49_09990	COG0583	DNA-binding transcription factor activity
O0R49_10000	COG1132	(ABC) transporter
O0R49_10005	COG0789	Transcriptional regulator
O0R49_10005	COG4978	Transcriptional regulator
O0R49_10010	COG0454	-acetyltransferase
O0R49_10015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O0R49_10020	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O0R49_10025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
O0R49_10040	COG0243	molybdopterin cofactor binding
O0R49_10050	COG1070	Carbohydrate kinase
O0R49_10055	COG2115	Belongs to the xylose isomerase family
O0R49_10060	COG1940	carbohydrate kinase activity
O0R49_10070	COG2211	Major facilitator Superfamily
O0R49_10080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R49_10085	COG1994	Peptidase M50
O0R49_10105	COG1309	transcriptional regulator
O0R49_10110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R49_10115	COG3708	Transcriptional regulator
O0R49_10120	COG2378	regulation of single-species biofilm formation
O0R49_10130	COG0640	Transcriptional regulator
O0R49_10135	COG0531	amino acid
O0R49_10140	COG0741	lytic transglycosylase activity
O0R49_10145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O0R49_10150	COG2079	MmgE PrpD family protein
O0R49_10155	COG0372	Belongs to the citrate synthase family
O0R49_10160	COG2322	membrane
O0R49_10170	COG3584	3D domain protein
O0R49_10170	COG1388	LysM domain
O0R49_10175	COG0514	ATP-dependent DNA helicase (RecQ)
O0R49_10185	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O0R49_10210	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_10215	COG1657	PFAM Prenyltransferase squalene oxidase
O0R49_10220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O0R49_10225	COG0385	Bile acid
O0R49_10230	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R49_10235	COG0567	Dehydrogenase, E1 component
O0R49_10240	COG4548	von Willebrand factor, type A
O0R49_10245	COG0714	Associated with various cellular activities
O0R49_10250	COG2032	superoxide dismutase activity
O0R49_10255	COG0791	NLP P60 protein
O0R49_10255	COG1388	LysM domain
O0R49_10260	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
O0R49_10270	COG0534	Mate efflux family protein
O0R49_10275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R49_10280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R49_10290	COG2962	Rard protein
O0R49_10305	COG1733	regulation of RNA biosynthetic process
O0R49_10310	COG0778	Nitroreductase
O0R49_10320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R49_10325	COG0793	Belongs to the peptidase S41A family
O0R49_10325	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_10330	COG2226	methyltransferase
O0R49_10340	COG1876	peptidase activity
O0R49_10345	COG0813	purine-nucleoside phosphorylase activity
O0R49_10355	COG0671	phosphoesterase, PA-phosphatase related
O0R49_10375	COG4479	Belongs to the UPF0346 family
O0R49_10385	COG1509	lysine 2,3-aminomutase activity
O0R49_10390	COG3829	transcription factor binding
O0R49_10395	COG0463	Glycosyl transferase, family 2
O0R49_10410	COG4641	Protein conserved in bacteria
O0R49_10420	COG1086	Polysaccharide biosynthesis protein
O0R49_10425	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O0R49_10430	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O0R49_10435	COG1846	Transcriptional regulator
O0R49_10455	COG4698	Protein conserved in bacteria
O0R49_10460	COG2755	lipolytic protein G-D-S-L family
O0R49_10465	COG1999	signal sequence binding
O0R49_10480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O0R49_10485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
O0R49_10490	COG1272	protein, Hemolysin III
O0R49_10495	COG0204	Acyl-transferase
O0R49_10500	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O0R49_10505	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O0R49_10510	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O0R49_10520	COG2521	methyltransferase
O0R49_10520	COG2136	Putative SAM-dependent methyltransferase
O0R49_10530	COG0129	dihydroxy-acid dehydratase activity
O0R49_10535	COG1413	lyase activity
O0R49_10540	COG1418	mRNA catabolic process
O0R49_10545	COG0386	Belongs to the glutathione peroxidase family
O0R49_10550	COG2759	Belongs to the formate--tetrahydrofolate ligase family
O0R49_10555	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
O0R49_10560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O0R49_10570	COG1278	Cold shock
O0R49_10585	COG0328	RNA-DNA hybrid ribonuclease activity
O0R49_10590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
O0R49_10595	COG0328	RNA-DNA hybrid ribonuclease activity
O0R49_10605	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O0R49_10615	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O0R49_10625	COG1755	Isoprenylcysteine carboxyl methyltransferase
O0R49_10630	COG3424	synthase
O0R49_10635	COG0726	polysaccharide deacetylase
O0R49_10640	COG2233	PERMEase
O0R49_10645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0R49_10650	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
O0R49_10655	COG1199	ATP-dependent helicase activity
O0R49_10665	COG0116	Belongs to the methyltransferase superfamily
O0R49_10675	COG3599	regulation of cell shape
O0R49_10680	COG4474	Belongs to the UPF0398 family
O0R49_10690	COG3359	exonuclease
O0R49_10710	COG0457	Tetratricopeptide repeat
O0R49_10725	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_10730	COG4824	toxin secretion phage lysis holin
O0R49_10755	COG1705	Flagellar rod assembly protein muramidase FlgJ
O0R49_10755	COG1388	LysM domain
O0R49_10835	COG4626	Terminase
O0R49_10835	COG1802	Transcriptional regulator
O0R49_10935	COG3620	sequence-specific DNA binding
O0R49_10950	COG1902	pentaerythritol trinitrate reductase activity
O0R49_10955	COG2190	(PTS) system
O0R49_10960	COG0071	Belongs to the small heat shock protein (HSP20) family
O0R49_10990	COG3331	DNA recombination
O0R49_10995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R49_10995	COG4499	WXG100 protein secretion system (Wss), protein YukC
O0R49_11005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
O0R49_11010	COG3935	DnaD domain protein
O0R49_11015	COG0017	Asparaginyl-tRNA synthetase
O0R49_11020	COG5353	protein conserved in bacteria
O0R49_11030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
O0R49_11030	COG1199	ATP-dependent helicase activity
O0R49_11035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O0R49_11040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O0R49_11045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O0R49_11055	COG0617	tRNA 3'-terminal CCA addition
O0R49_11060	COG0438	transferase activity, transferring glycosyl groups
O0R49_11065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O0R49_11070	COG1803	Methylglyoxal synthase
O0R49_11075	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O0R49_11080	COG1694	Mazg nucleotide pyrophosphohydrolase
O0R49_11085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R49_11095	COG4347	Protein of unknown function (DUF1405)
O0R49_11100	COG2010	Cytochrome c
O0R49_11100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O0R49_11105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O0R49_11110	COG0723	plastoquinol--plastocyanin reductase activity
O0R49_11120	COG5582	Belongs to the UPF0302 family
O0R49_11125	COG0457	Tetratricopeptide repeat
O0R49_11130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O0R49_11135	COG0287	Prephenate dehydrogenase
O0R49_11140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O0R49_11145	COG0159	tryptophan synthase activity
O0R49_11150	COG0133	tryptophan synthase activity
O0R49_11155	COG0135	phosphoribosylanthranilate isomerase activity
O0R49_11160	COG0134	indole-3-glycerol-phosphate synthase activity
O0R49_11175	COG4401	Chorismate mutase type I
O0R49_11180	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O0R49_11185	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O0R49_11190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
O0R49_11195	COG0105	UTP biosynthetic process
O0R49_11200	COG0142	geranyltranstransferase activity
O0R49_11205	COG2226	methyltransferase
O0R49_11210	COG0142	geranyltranstransferase activity
O0R49_11220	COG0302	gtp cyclohydrolase
O0R49_11225	COG0776	regulation of translation
O0R49_11230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
O0R49_11245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O0R49_11250	COG1160	GTP binding
O0R49_11275	COG1304	FMN binding
O0R49_11280	COG0539	negative regulation of cytoplasmic translation
O0R49_11285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O0R49_11295	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
O0R49_11300	COG2959	enzyme of heme biosynthesis
O0R49_11305	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_11305	COG3773	Cell wall hydrolase
O0R49_11310	COG2339	peptidase activity
O0R49_11315	COG0492	ferredoxin-NADP+ reductase activity
O0R49_11320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0R49_11325	COG4862	establishment of competence for transformation
O0R49_11330	COG1408	metallophosphoesterase
O0R49_11340	COG1388	LysM domain
O0R49_11345	COG1266	CAAX protease self-immunity
O0R49_11350	COG0514	ATP-dependent DNA helicase (RecQ)
O0R49_11355	COG4955	Helix-turn-helix domain
O0R49_11360	COG1141	Ferredoxin
O0R49_11365	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
O0R49_11370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O0R49_11375	COG0791	NLP P60 protein
O0R49_11375	COG1388	LysM domain
O0R49_11385	COG1595	DNA-templated transcription, initiation
O0R49_11390	COG5002	protein histidine kinase activity
O0R49_11395	COG0745	RESPONSE REGULATOR receiver
O0R49_11400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O0R49_11405	COG1333	cytochrome c biogenesis protein
O0R49_11410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_11415	COG1187	pseudouridine synthase activity
O0R49_11420	COG0700	Nucleoside recognition
O0R49_11425	COG2715	membrane protein required for spore maturation
O0R49_11430	COG1686	Belongs to the peptidase S11 family
O0R49_11440	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O0R49_11445	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O0R49_11455	COG1547	Domain of unknown function (DUF309)
O0R49_11460	COG0456	acetyltransferase
O0R49_11465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
O0R49_11475	COG0307	riboflavin synthase, alpha
O0R49_11495	COG2814	Major facilitator Superfamily
O0R49_11500	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O0R49_11505	COG4086	secreted protein
O0R49_11510	COG0019	diaminopimelate decarboxylase activity
O0R49_11515	COG0697	spore germination
O0R49_11530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O0R49_11550	COG1191	sigma factor activity
O0R49_11555	COG2172	sigma factor antagonist activity
O0R49_11565	COG1686	Belongs to the peptidase S11 family
O0R49_11570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
O0R49_11575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
O0R49_11580	COG4974	Belongs to the 'phage' integrase family
O0R49_11590	COG0735	belongs to the Fur family
O0R49_11595	COG1300	Membrane
O0R49_11600	COG1404	Belongs to the peptidase S8 family
O0R49_11610	COG2153	protein acetylation
O0R49_11615	COG1379	DNA repair
O0R49_11620	COG0494	nUDIX hydrolase
O0R49_11625	COG0667	Aldo Keto reductase
O0R49_11635	COG1073	alpha beta
O0R49_11640	COG0457	Tetratricopeptide repeat
O0R49_11650	COG4918	Iron-sulphur cluster biosynthesis
O0R49_11655	COG0456	acetyltransferase
O0R49_11655	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O0R49_11660	COG0456	acetyltransferase
O0R49_11670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O0R49_11680	COG2211	Major facilitator Superfamily
O0R49_11685	COG1072	(Pantothenic acid kinase))
O0R49_11690	COG0446	pyridine nucleotide-disulphide oxidoreductase
O0R49_11695	COG0300	oxidoreductase activity
O0R49_11700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R49_11705	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0R49_11715	COG4187	Peptidase family M20/M25/M40
O0R49_11720	COG1902	pentaerythritol trinitrate reductase activity
O0R49_11725	COG0596	Alpha beta hydrolase
O0R49_11730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O0R49_11740	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
O0R49_11745	COG2188	Transcriptional regulator
O0R49_11750	COG2723	6-phospho-beta-galactosidase activity
O0R49_11755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R49_11760	COG1447	Phosphotransferase system cellobiose-specific component IIA
O0R49_11765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R49_11770	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_11780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O0R49_11785	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O0R49_11800	COG0706	membrane insertase activity
O0R49_11810	COG2195	Cleaves the N-terminal amino acid of tripeptides
O0R49_11815	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O0R49_11820	COG0346	lactoylglutathione lyase activity
O0R49_11830	COG1376	ErfK ybiS ycfS ynhG family protein
O0R49_11835	COG4129	membrane
O0R49_11840	COG1126	abc transporter atp-binding protein
O0R49_11845	COG0765	amino acid transport
O0R49_11850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_11860	COG1597	lipid kinase activity
O0R49_11870	COG0508	dehydrogenase complex catalyzes the overall conversion of
O0R49_11875	COG0022	dehydrogenase e1 component
O0R49_11880	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O0R49_11885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O0R49_11890	COG3426	butyrate kinase activity
O0R49_11895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0R49_11900	COG0280	phosphate acetyltransferase
O0R49_11905	COG3829	transcription factor binding
O0R49_11905	COG3290	protein histidine kinase activity
O0R49_11915	COG0584	glycerophosphoryl diester phosphodiesterase
O0R49_11920	COG0457	Tetratricopeptide repeat
O0R49_11925	COG0745	RESPONSE REGULATOR receiver
O0R49_11930	COG0750	zinc metalloprotease
O0R49_11935	COG0497	DNA recombination
O0R49_11940	COG1438	arginine binding
O0R49_11945	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
O0R49_11950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O0R49_11955	COG0142	geranyltranstransferase activity
O0R49_11960	COG1722	exodeoxyribonuclease VII activity
O0R49_11965	COG1570	exodeoxyribonuclease VII activity
O0R49_11970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O0R49_11975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O0R49_11980	COG1302	Protein conserved in bacteria
O0R49_11985	COG0439	Biotin carboxylase
O0R49_11990	COG0511	ligase activity, forming carbon-carbon bonds
O0R49_12030	COG3854	ATPases associated with a variety of cellular activities
O0R49_12040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O0R49_12045	COG0006	proline dipeptidase activity
O0R49_12050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O0R49_12060	COG3872	metal-dependent enzyme
O0R49_12070	COG1752	Esterase of the alpha-beta hydrolase superfamily
O0R49_12075	COG1321	iron dependent repressor
O0R49_12080	COG0095	Lipoate-protein ligase
O0R49_12085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R49_12090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O0R49_12095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
O0R49_12100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O0R49_12105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O0R49_12130	COG0681	Belongs to the peptidase S26 family
O0R49_12165	COG4970	Tfp pilus assembly protein FimT
O0R49_12170	COG4537	Required for transformation and DNA binding
O0R49_12175	COG1459	type II secretion system
O0R49_12180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
O0R49_12185	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_12195	COG1393	Belongs to the ArsC family
O0R49_12205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R49_12215	COG0011	TIGRFAM Protein of
O0R49_12220	COG2814	Major facilitator Superfamily
O0R49_12225	COG2866	Carboxypeptidase
O0R49_12230	COG1368	sulfuric ester hydrolase activity
O0R49_12235	COG1940	carbohydrate kinase activity
O0R49_12240	COG4483	Protein conserved in bacteria
O0R49_12245	COG0705	Rhomboid family
O0R49_12245	COG0457	Tetratricopeptide repeat
O0R49_12255	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O0R49_12260	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O0R49_12270	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O0R49_12275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O0R49_12280	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O0R49_12285	COG0581	inorganic phosphate transmembrane transporter activity
O0R49_12290	COG0573	inorganic phosphate transmembrane transporter activity
O0R49_12295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
O0R49_12300	COG0768	penicillin binding
O0R49_12305	COG0477	Major facilitator Superfamily
O0R49_12310	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O0R49_12315	COG2839	Protein conserved in bacteria
O0R49_12320	COG5521	maltodextrose utilization protein MalA
O0R49_12325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O0R49_12330	COG1388	LysM domain
O0R49_12335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
O0R49_12340	COG4709	membrane
O0R49_12345	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
O0R49_12350	COG1940	carbohydrate kinase activity
O0R49_12360	COG0735	belongs to the Fur family
O0R49_12365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O0R49_12370	COG1121	(ABC) transporter
O0R49_12375	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R49_12385	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
O0R49_12390	COG0513	Belongs to the DEAD box helicase family
O0R49_12400	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O0R49_12405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O0R49_12410	COG2384	SAM-dependent methyltransferase
O0R49_12415	COG2010	Cytochrome c
O0R49_12420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
O0R49_12425	COG0358	DNA primase activity
O0R49_12430	COG1671	Belongs to the UPF0178 family
O0R49_12435	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
O0R49_12440	COG0517	IMP dehydrogenase activity
O0R49_12445	COG0751	glycine-tRNA ligase activity
O0R49_12450	COG0752	glycyl-tRNA synthetase alpha subunit
O0R49_12455	COG1381	Involved in DNA repair and RecF pathway recombination
O0R49_12465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
O0R49_12470	COG0295	cytidine deaminase activity
O0R49_12475	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
O0R49_12480	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O0R49_12485	COG1480	7TM receptor with intracellular HD hydrolase
O0R49_12490	COG1702	phosphate starvation-inducible protein PhoH
O0R49_12495	COG0561	phosphatase activity
O0R49_12510	COG4864	UPF0365 protein
O0R49_12515	COG1030	water channel activity
O0R49_12520	COG1610	YqeY-like protein
O0R49_12530	COG1283	sodium-dependent phosphate transmembrane transporter activity
O0R49_12535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O0R49_12540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
O0R49_12545	COG2264	protein methyltransferase activity
O0R49_12550	COG0484	heat shock protein binding
O0R49_12555	COG0443	Heat shock 70 kDa protein
O0R49_12560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O0R49_12565	COG1420	regulation of RNA biosynthetic process
O0R49_12570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
O0R49_12575	COG0481	GTPase activity
O0R49_12585	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_12590	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
O0R49_12595	COG0268	Binds directly to 16S ribosomal RNA
O0R49_12600	COG1466	dna polymerase III delta subunit
O0R49_12610	COG0658	competence protein
O0R49_12610	COG2333	competence protein COMEC
O0R49_12615	COG2131	deaminase
O0R49_12620	COG1555	photosystem II stabilization
O0R49_12625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
O0R49_12630	COG2226	methyltransferase
O0R49_12635	COG0799	negative regulation of ribosome biogenesis
O0R49_12640	COG1713	HD superfamily hydrolase involved in NAD metabolism
O0R49_12645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O0R49_12650	COG1534	Rna-binding protein
O0R49_12655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O0R49_12660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
O0R49_12665	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
O0R49_12680	COG2755	lipolytic protein G-D-S-L family
O0R49_12690	COG0457	Tetratricopeptide repeat
O0R49_12710	COG2318	DinB family
O0R49_12735	COG0726	polysaccharide deacetylase
O0R49_12765	COG2160	L-arabinose isomerase activity
O0R49_12780	COG1609	Transcriptional regulator
O0R49_12790	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
O0R49_12795	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
O0R49_12800	COG1733	regulation of RNA biosynthetic process
O0R49_12805	COG0657	acetylesterase activity
O0R49_12825	COG2602	Beta-lactamase
O0R49_12830	COG1960	acyl-CoA dehydrogenase activity
O0R49_12835	COG1126	abc transporter atp-binding protein
O0R49_12840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_12845	COG0765	amino acid transport
O0R49_12855	COG3546	catalase activity
O0R49_12860	COG1063	alcohol dehydrogenase
O0R49_12870	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_12875	COG0842	Transport permease protein
O0R49_12880	COG1511	domain protein
O0R49_12880	COG0842	Transport permease protein
O0R49_12885	COG1131	(ABC) transporter
O0R49_12890	COG2226	methyltransferase
O0R49_12895	COG1063	alcohol dehydrogenase
O0R49_12900	COG2226	methyltransferase
O0R49_12925	COG0626	cystathionine gamma-synthase activity
O0R49_12930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R49_12935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
O0R49_12940	COG2226	methyltransferase
O0R49_12955	COG0768	penicillin binding
O0R49_12960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O0R49_12970	COG0572	uridine kinase
O0R49_12975	COG0826	peptidase U32
O0R49_12980	COG0826	peptidase U32
O0R49_12985	COG4122	O-methyltransferase activity
O0R49_12990	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
O0R49_12995	COG0183	Belongs to the thiolase family
O0R49_13000	COG0318	PFAM AMP-dependent synthetase and ligase
O0R49_13005	COG1268	BioY protein
O0R49_13010	COG3906	Belongs to the UPF0473 family
O0R49_13015	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O0R49_13020	COG4472	Bacterial protein of unknown function (DUF965)
O0R49_13025	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O0R49_13030	COG0628	permease
O0R49_13035	COG1126	abc transporter atp-binding protein
O0R49_13040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_13045	COG0765	amino acid transport
O0R49_13050	COG0765	amino acid transport
O0R49_13065	COG3881	PFAM PRC-barrel domain
O0R49_13070	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
O0R49_13075	COG0457	Tetratricopeptide repeat
O0R49_13080	COG0482	sulfurtransferase activity
O0R49_13085	COG1104	cysteine desulfurase activity
O0R49_13090	COG1959	2 iron, 2 sulfur cluster binding
O0R49_13095	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
O0R49_13100	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
O0R49_13115	COG0124	histidyl-tRNA synthetase
O0R49_13125	COG3103	Sh3 type 3 domain protein
O0R49_13125	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_13125	COG4991	sh3 domain protein
O0R49_13130	COG1490	D-aminoacyl-tRNA deacylase activity
O0R49_13135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O0R49_13140	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O0R49_13145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
O0R49_13145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
O0R49_13150	COG5416	Lipopolysaccharide assembly protein A domain
O0R49_13155	COG0490	domain, Protein
O0R49_13160	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O0R49_13160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O0R49_13170	COG2244	polysaccharide biosynthetic process
O0R49_13175	COG2323	membrane
O0R49_13185	COG1862	Preprotein translocase
O0R49_13190	COG0343	queuine tRNA-ribosyltransferase activity
O0R49_13195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
O0R49_13205	COG2255	four-way junction helicase activity
O0R49_13210	COG0632	four-way junction helicase activity
O0R49_13220	COG2112	serine threonine protein kinase
O0R49_13235	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O0R49_13250	COG1388	LysM domain
O0R49_13250	COG1388	LysM domain
O0R49_13255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
O0R49_13260	COG0157	Belongs to the NadC ModD family
O0R49_13265	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
O0R49_13270	COG1104	cysteine desulfurase activity
O0R49_13275	COG1827	regulation of RNA biosynthetic process
O0R49_13280	COG0077	Prephenate dehydratase
O0R49_13285	COG4492	Belongs to the UPF0735 family
O0R49_13290	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O0R49_13295	COG3290	protein histidine kinase activity
O0R49_13300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O0R49_13305	COG2868	ribosomal protein
O0R49_13310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O0R49_13315	COG1994	Peptidase M50
O0R49_13320	COG0739	heme binding
O0R49_13325	COG2894	cell division
O0R49_13330	COG0850	regulation of cytokinetic process
O0R49_13335	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
O0R49_13345	COG1077	Cell shape determining protein MreB Mrl
O0R49_13375	COG0457	Tetratricopeptide repeat
O0R49_13385	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R49_13385	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_13430	COG3953	SLT domain
O0R49_13430	COG5280	Phage tail tape measure protein TP901
O0R49_13600	COG0424	maF-like protein
O0R49_13610	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
O0R49_13615	COG0285	dihydrofolate synthase activity
O0R49_13620	COG0525	valine-tRNA ligase activity
O0R49_13630	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O0R49_13635	COG1388	LysM domain
O0R49_13640	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O0R49_13645	COG0113	porphobilinogen synthase activity
O0R49_13650	COG1587	Uroporphyrinogen-III synthase
O0R49_13655	COG0181	hydroxymethylbilane synthase activity
O0R49_13660	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O0R49_13665	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O0R49_13675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
O0R49_13680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
O0R49_13685	COG0470	DNA polymerase III
O0R49_13685	COG1067	ATP-dependent peptidase activity
O0R49_13690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O0R49_13695	COG0544	peptidyl-prolyl cis-trans isomerase activity
O0R49_13700	COG0457	Tetratricopeptide repeat
O0R49_13700	COG1477	protein flavinylation
O0R49_13705	COG0066	3-isopropylmalate dehydratase activity
O0R49_13710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O0R49_13715	COG0473	3-isopropylmalate dehydrogenase activity
O0R49_13720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O0R49_13725	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O0R49_13730	COG0440	acetolactate synthase activity
O0R49_13735	COG0028	Belongs to the TPP enzyme family
O0R49_13740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R49_13745	COG2706	6-phosphogluconolactonase activity
O0R49_13750	COG3339	Conserved Protein
O0R49_13755	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
O0R49_13760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O0R49_13765	COG1696	Membrane protein involved in D-alanine export
O0R49_13790	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_13800	COG0622	Phosphoesterase
O0R49_13805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O0R49_13810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O0R49_13815	COG5401	PFAM Sporulation and spore germination
O0R49_13820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O0R49_13825	COG1846	Transcriptional regulator
O0R49_13850	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_13850	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R49_13940	COG0740	serine-type endopeptidase activity
O0R49_13985	COG0582	viral genome integration into host DNA
O0R49_13990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
O0R49_14130	COG2197	response regulator
O0R49_14135	COG2851	Citrate transporter
O0R49_14140	COG0583	DNA-binding transcription factor activity
O0R49_14145	COG2828	Protein conserved in bacteria
O0R49_14155	COG0824	Thioesterase
O0R49_14160	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O0R49_14165	COG1053	succinate dehydrogenase
O0R49_14170	COG2009	succinate dehydrogenase
O0R49_14175	COG1719	4-vinyl reductase, 4VR
O0R49_14180	COG0527	aspartate kinase activity
O0R49_14185	COG0322	excinuclease ABC activity
O0R49_14190	COG3118	belongs to the thioredoxin family
O0R49_14195	COG3534	alpha-L-arabinofuranosidase
O0R49_14200	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O0R49_14205	COG2086	electron transfer activity
O0R49_14210	COG1024	Enoyl-CoA hydratase
O0R49_14215	COG1309	transcriptional regulator
O0R49_14220	COG0318	PFAM AMP-dependent synthetase and ligase
O0R49_14230	COG3766	membrane
O0R49_14235	COG1193	negative regulation of DNA recombination
O0R49_14240	COG1796	DNA polymerase
O0R49_14240	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O0R49_14245	COG1286	toxin biosynthetic process
O0R49_14250	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
O0R49_14255	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O0R49_14260	COG0072	phenylalanine-tRNA ligase activity
O0R49_14260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R49_14265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O0R49_14270	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O0R49_14280	COG1966	Carbon starvation protein
O0R49_14285	COG1363	Peptidase, m42
O0R49_14295	COG3326	Membrane
O0R49_14300	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O0R49_14305	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O0R49_14310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
O0R49_14315	COG1346	cytolysis
O0R49_14325	COG3279	Response regulator of the LytR AlgR family
O0R49_14330	COG3275	phosphorelay sensor kinase activity
O0R49_14335	COG1011	Hydrolase
O0R49_14345	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O0R49_14355	COG0398	Pfam SNARE associated Golgi protein
O0R49_14360	COG1484	DNA-dependent DNA replication
O0R49_14365	COG3611	Membrane attachment protein
O0R49_14370	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O0R49_14380	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
O0R49_14385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O0R49_14390	COG0237	dephospho-CoA kinase activity
O0R49_14395	COG1971	Probably functions as a manganese efflux pump
O0R49_14400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O0R49_14405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O0R49_14405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
O0R49_14410	COG5002	protein histidine kinase activity
O0R49_14415	COG0745	RESPONSE REGULATOR receiver
O0R49_14420	COG0039	L-malate dehydrogenase activity
O0R49_14425	COG0538	isocitrate dehydrogenase activity
O0R49_14430	COG0372	Belongs to the citrate synthase family
O0R49_14435	COG2707	UPF0756 membrane protein
O0R49_14440	COG0628	permease
O0R49_14445	COG3030	protein affecting phage T7 exclusion by the F plasmid
O0R49_14455	COG0205	6-phosphofructokinase activity
O0R49_14460	COG0825	malonyl-CoA metabolic process
O0R49_14465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
O0R49_14470	COG0281	malic enzyme
O0R49_14475	COG0587	DNA-directed DNA polymerase activity
O0R49_14495	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O0R49_14505	COG4109	DRTGG domain
O0R49_14510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O0R49_14515	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_14525	COG0165	Argininosuccinate lyase
O0R49_14530	COG0137	argininosuccinate synthase activity
O0R49_14535	COG0521	Mo-molybdopterin cofactor biosynthetic process
O0R49_14540	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O0R49_14545	COG0827	DNA restriction-modification system
O0R49_14550	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
O0R49_14555	COG3874	Sporulation protein YtfJ
O0R49_14565	COG1714	RDD family
O0R49_14570	COG0616	signal peptide processing
O0R49_14575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O0R49_14585	COG3239	Fatty acid desaturase
O0R49_14590	COG4585	Histidine kinase
O0R49_14595	COG2197	response regulator
O0R49_14600	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_14605	COG0745	RESPONSE REGULATOR receiver
O0R49_14610	COG0642	Histidine kinase
O0R49_14615	COG0772	Belongs to the SEDS family
O0R49_14620	COG1695	Transcriptional regulator
O0R49_14625	COG1136	(ABC) transporter
O0R49_14630	COG0577	efflux transmembrane transporter activity
O0R49_14635	COG0402	S-adenosylhomocysteine deaminase activity
O0R49_14640	COG2249	NAD(P)H dehydrogenase (quinone) activity
O0R49_14650	COG1279	arginine transmembrane transporter activity
O0R49_14655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O0R49_14665	COG0301	tRNA thio-modification
O0R49_14670	COG1104	cysteine desulfurase activity
O0R49_14675	COG1114	Component of the transport system for branched-chain amino acids
O0R49_14680	COG1114	Component of the transport system for branched-chain amino acids
O0R49_14685	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
O0R49_14690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O0R49_14695	COG1309	transcriptional regulator
O0R49_14700	COG1956	GAF domain-containing protein
O0R49_14705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O0R49_14720	COG1335	isochorismatase
O0R49_14725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
O0R49_14730	COG2329	Antibiotic biosynthesis monooxygenase
O0R49_14735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O0R49_14740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O0R49_14745	COG0454	-acetyltransferase
O0R49_14750	COG0517	IMP dehydrogenase activity
O0R49_14755	COG0123	including yeast histone deacetylase and acetoin utilization protein
O0R49_14760	COG1609	Transcriptional regulator
O0R49_14765	COG1605	Chorismate mutase
O0R49_14765	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
O0R49_14770	COG3118	belongs to the thioredoxin family
O0R49_14775	COG4980	gas vesicle protein
O0R49_14780	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
O0R49_14785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O0R49_14790	COG1674	ftsk spoiiie
O0R49_14795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O0R49_14800	COG4848	Belongs to the UPF0354 family
O0R49_14805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_14820	COG1363	Peptidase, m42
O0R49_14825	COG5584	Small secreted protein
O0R49_14830	COG0281	malic enzyme
O0R49_14835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O0R49_14840	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O0R49_14850	COG0510	thiamine kinase activity
O0R49_14855	COG1597	lipid kinase activity
O0R49_14865	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
O0R49_14870	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O0R49_14875	COG3340	Belongs to the peptidase S51 family
O0R49_14880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O0R49_14885	COG2252	PERMEase
O0R49_14890	COG1349	DNA-binding transcription factor activity
O0R49_14895	COG1187	pseudouridine synthase activity
O0R49_14900	COG2244	polysaccharide biosynthetic process
O0R49_14905	COG2081	HI0933 family
O0R49_14915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O0R49_14920	COG3196	Protein conserved in bacteria
O0R49_14930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O0R49_14935	COG5578	integral membrane protein
O0R49_14940	COG0673	inositol 2-dehydrogenase activity
O0R49_14945	COG1653	transport
O0R49_14950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
O0R49_14955	COG4209	transmembrane transport
O0R49_14960	COG2207	Transcriptional regulator
O0R49_14965	COG1733	regulation of RNA biosynthetic process
O0R49_14970	COG2814	Major facilitator Superfamily
O0R49_14975	COG0656	L-ascorbic acid biosynthetic process
O0R49_14980	COG1653	transport
O0R49_14985	COG0395	ABC-type sugar transport system, permease component
O0R49_14990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R49_14995	COG1073	alpha beta
O0R49_15000	COG0495	leucyl-tRNA aminoacylation
O0R49_15010	COG2202	Pas domain
O0R49_15010	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_15015	COG2433	Pfam Transposase IS66
O0R49_15020	COG0577	efflux transmembrane transporter activity
O0R49_15025	COG1136	(ABC) transporter
O0R49_15035	COG1131	(ABC) transporter
O0R49_15040	COG1725	Transcriptional regulator
O0R49_15055	COG1242	4 iron, 4 sulfur cluster binding
O0R49_15060	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
O0R49_15070	COG2267	carboxylic ester hydrolase activity
O0R49_15075	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
O0R49_15080	COG0367	asparagine synthase
O0R49_15085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O0R49_15090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
O0R49_15100	COG1506	peptidase
O0R49_15105	COG1233	COG1233 Phytoene dehydrogenase and related
O0R49_15125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O0R49_15130	COG1116	anion transmembrane transporter activity
O0R49_15135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O0R49_15140	COG0494	nUDIX hydrolase
O0R49_15145	COG2310	stress, protein
O0R49_15160	COG4824	toxin secretion phage lysis holin
O0R49_15170	COG0783	Belongs to the Dps family
O0R49_15185	COG1854	S-ribosylhomocysteine lyase activity
O0R49_15190	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
O0R49_15195	COG0288	reversible hydration of carbon dioxide
O0R49_15200	COG0803	Belongs to the bacterial solute-binding protein 9 family
O0R49_15200	COG3443	Belongs to the bacterial solute-binding protein 9 family
O0R49_15205	COG0254	rRNA binding
O0R49_15210	COG1271	oxidase subunit
O0R49_15215	COG1294	oxidase, subunit
O0R49_15230	COG4948	Mandelate Racemase Muconate Lactonizing
O0R49_15235	COG0318	PFAM AMP-dependent synthetase and ligase
O0R49_15240	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
O0R49_15245	COG0596	Alpha beta hydrolase
O0R49_15250	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O0R49_15255	COG1169	isochorismate synthase
O0R49_15260	COG1575	Belongs to the MenA family. Type 1 subfamily
O0R49_15265	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
O0R49_15395	COG3859	Proton-coupled thiamine transporter YuaJ
O0R49_15400	COG1247	-acetyltransferase
O0R49_15405	COG3339	Conserved Protein
O0R49_15410	COG0772	Belongs to the SEDS family
O0R49_15415	COG0772	Belongs to the SEDS family
O0R49_15420	COG2268	Band 7 protein
O0R49_15425	COG1585	Membrane protein implicated in regulation of membrane protease activity
O0R49_15430	COG2318	DinB family
O0R49_15435	COG1454	alcohol dehydrogenase
O0R49_15440	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_15445	COG1510	regulation of RNA biosynthetic process
O0R49_15460	COG5632	N-Acetylmuramoyl-L-alanine amidase
O0R49_15460	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_15530	COG3778	Protein conserved in bacteria
O0R49_15535	COG3299	homolog of phage Mu protein gp47
O0R49_15540	COG3628	GPW Gp25 family protein
O0R49_15550	COG4193	domain, Protein
O0R49_15555	COG1652	LysM domain
O0R49_15560	COG3953	SLT domain
O0R49_15560	COG5280	Phage tail tape measure protein TP901
O0R49_15610	COG4653	Phage capsid family
O0R49_15615	COG0338	D12 class N6 adenine-specific DNA methyltransferase
O0R49_15620	COG5518	Phage portal protein
O0R49_15625	COG1783	phage Terminase large subunit
O0R49_15630	COG5484	DNA packaging
O0R49_15635	COG1595	DNA-templated transcription, initiation
O0R49_15645	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
O0R49_15665	COG1396	sequence-specific DNA binding
O0R49_15690	COG0628	permease
O0R49_15700	COG0673	inositol 2-dehydrogenase activity
O0R49_15705	COG0693	protein deglycase activity
O0R49_15710	COG0840	transmembrane signaling receptor activity
O0R49_15715	COG0840	transmembrane signaling receptor activity
O0R49_15720	COG0840	transmembrane signaling receptor activity
O0R49_15725	COG0840	transmembrane signaling receptor activity
O0R49_15740	COG2070	2-Nitropropane dioxygenase
O0R49_15745	COG0432	Pfam Uncharacterised protein family UPF0047
O0R49_15750	COG1253	flavin adenine dinucleotide binding
O0R49_15755	COG2738	Putative neutral zinc metallopeptidase
O0R49_15765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
O0R49_15780	COG0166	Belongs to the GPI family
O0R49_15785	COG1979	alcohol dehydrogenase
O0R49_15790	COG1979	alcohol dehydrogenase
O0R49_15795	COG2155	Conserved Protein
O0R49_15800	COG1098	S1 RNA binding domain
O0R49_15805	COG0436	Aminotransferase
O0R49_15810	COG1522	sequence-specific DNA binding
O0R49_15815	COG2267	carboxylic ester hydrolase activity
O0R49_15825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
O0R49_15830	COG2205	protein histidine kinase activity
O0R49_15845	COG5018	Exonuclease
O0R49_15850	COG2814	Major facilitator Superfamily
O0R49_15855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R49_15860	COG3011	Protein conserved in bacteria
O0R49_15870	COG3290	protein histidine kinase activity
O0R49_15875	COG4565	transcriptional regulatory protein
O0R49_15880	COG1744	ABC transporter substrate-binding protein PnrA-like
O0R49_15885	COG3845	ABC transporter
O0R49_15890	COG4603	Belongs to the binding-protein-dependent transport system permease family
O0R49_15895	COG1079	Belongs to the binding-protein-dependent transport system permease family
O0R49_15900	COG3493	citrate carrier protein
O0R49_15910	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O0R49_15910	COG2111	Na H antiporter
O0R49_15915	COG2111	Na H antiporter
O0R49_15920	COG1006	Multisubunit Na H antiporter MnhC subunit
O0R49_15925	COG0651	ATP synthesis coupled electron transport
O0R49_15930	COG1863	multisubunit Na H antiporter MnhE subunit
O0R49_15935	COG2212	antiporter activity
O0R49_15940	COG1320	monovalent cation:proton antiporter activity
O0R49_15945	COG2050	protein possibly involved in aromatic compounds catabolism
O0R49_15950	COG2197	response regulator
O0R49_15955	COG4585	Histidine kinase
O0R49_15965	COG0142	geranyltranstransferase activity
O0R49_15980	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
O0R49_15985	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O0R49_15990	COG1335	isochorismatase
O0R49_15995	COG5506	Protein of unknown function (DUF1694)
O0R49_16015	COG0628	permease
O0R49_16030	COG1418	mRNA catabolic process
O0R49_16035	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_16045	COG1511	domain protein
O0R49_16050	COG0433	COG0433 Predicted ATPase
O0R49_16050	COG1674	ftsk spoiiie
O0R49_16055	COG4499	WXG100 protein secretion system (Wss), protein YukC
O0R49_16060	COG5417	Belongs to the EsaB family
O0R49_16065	COG4842	Belongs to the WXG100 family
O0R49_16070	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O0R49_16070	COG2508	Transcriptional regulator
O0R49_16075	COG0686	Belongs to the AlaDH PNT family
O0R49_16080	COG1268	BioY protein
O0R49_16085	COG4326	sporulation control protein
O0R49_16090	COG2056	Na+-H+ antiporter family
O0R49_16095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O0R49_16100	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
O0R49_16105	COG3584	3D domain protein
O0R49_16120	COG1252	NADH dehydrogenase
O0R49_16125	COG0492	ferredoxin-NADP+ reductase activity
O0R49_16150	COG0316	Belongs to the HesB IscA family
O0R49_16155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O0R49_16160	COG4844	belongs to the
O0R49_16165	COG1252	NADH dehydrogenase
O0R49_16175	COG4837	Protein of unknown function (DUF1462)
O0R49_16185	COG4946	Tricorn protease homolog
O0R49_16185	COG1506	peptidase
O0R49_16185	COG0823	Involved in the tonB-independent uptake of proteins
O0R49_16190	COG0083	homoserine kinase activity
O0R49_16195	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O0R49_16200	COG0460	homoserine dehydrogenase
O0R49_16205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0R49_16210	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
O0R49_16215	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
O0R49_16220	COG0647	UMP catabolic process
O0R49_16225	COG2445	Protein of unknown function DUF86
O0R49_16230	COG4470	Protein conserved in bacteria
O0R49_16240	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O0R49_16245	COG0739	heme binding
O0R49_16260	COG3377	Domain of unknown function (DUF1805)
O0R49_16265	COG0737	Belongs to the 5'-nucleotidase family
O0R49_16270	COG1801	Protein of unknown function DUF72
O0R49_16275	COG2508	Transcriptional regulator
O0R49_16280	COG2140	Oxalate decarboxylase
O0R49_16290	COG2814	Major facilitator Superfamily
O0R49_16295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
O0R49_16300	COG2356	endonuclease I
O0R49_16310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_16315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_16320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_16340	COG0642	Histidine kinase
O0R49_16340	COG5002	protein histidine kinase activity
O0R49_16345	COG0745	RESPONSE REGULATOR receiver
O0R49_16350	COG2311	Membrane
O0R49_16360	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O0R49_16365	COG1090	epimerase
O0R49_16370	COG1309	transcriptional regulator
O0R49_16380	COG0719	Fe-S assembly protein
O0R49_16385	COG0822	iron-sulfur transferase activity
O0R49_16390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
O0R49_16395	COG0719	Fe-S assembly protein
O0R49_16400	COG0396	ATPase activity
O0R49_16410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O0R49_16415	COG1464	Belongs to the NlpA lipoprotein family
O0R49_16420	COG2011	ABC-type metal ion transport system permease component
O0R49_16425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
O0R49_16435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_16440	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
O0R49_16450	COG0509	glycine decarboxylation via glycine cleavage system
O0R49_16455	COG1393	Belongs to the ArsC family
O0R49_16460	COG1960	acyl-CoA dehydrogenase activity
O0R49_16465	COG0183	Belongs to the thiolase family
O0R49_16470	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0R49_16470	COG1024	Enoyl-CoA hydratase
O0R49_16485	COG5577	PFAM Coat F domain
O0R49_16495	COG1120	ATPase activity
O0R49_16505	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_16510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R49_16515	COG0745	RESPONSE REGULATOR receiver
O0R49_16520	COG2205	protein histidine kinase activity
O0R49_16520	COG2770	Histidine kinase
O0R49_16530	COG1309	transcriptional regulator
O0R49_16535	COG0114	fumarate hydratase activity
O0R49_16545	COG0697	spore germination
O0R49_16550	COG0814	amino acid
O0R49_16565	COG2197	response regulator
O0R49_16570	COG4585	Histidine kinase
O0R49_16575	COG4758	membrane
O0R49_16585	COG1842	Phage shock protein A
O0R49_16590	COG4758	membrane
O0R49_16600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_16605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_16610	COG0492	ferredoxin-NADP+ reductase activity
O0R49_16615	COG2096	Adenosyltransferase
O0R49_16620	COG1120	ATPase activity
O0R49_16625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_16630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_16640	COG2721	sulfolactate sulfo-lyase activity
O0R49_16645	COG0246	Mannitol dehydrogenase
O0R49_16650	COG1609	Transcriptional regulator
O0R49_16655	COG1904	glucuronate isomerase
O0R49_16660	COG2205	protein histidine kinase activity
O0R49_16665	COG0745	RESPONSE REGULATOR receiver
O0R49_16670	COG1120	ATPase activity
O0R49_16675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_16680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_16685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_16690	COG0531	amino acid
O0R49_16705	COG1988	membrane-bound metal-dependent
O0R49_16710	COG1368	sulfuric ester hydrolase activity
O0R49_16715	COG0725	ABC transporter, periplasmic molybdate-binding protein
O0R49_16720	COG4149	molybdate abc transporter
O0R49_16725	COG0656	L-ascorbic acid biosynthetic process
O0R49_16730	COG1940	carbohydrate kinase activity
O0R49_16735	COG0025	NhaP-type Na H and K H
O0R49_16740	COG2860	membrane
O0R49_16745	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
O0R49_16750	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
O0R49_16755	COG2217	Heavy metal translocating P-type atpase
O0R49_16760	COG1121	(ABC) transporter
O0R49_16765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O0R49_16770	COG0803	Belongs to the bacterial solute-binding protein 9 family
O0R49_16780	COG3226	Transcriptional regulator
O0R49_16785	COG0784	Response regulator, receiver
O0R49_16790	COG4191	Histidine kinase
O0R49_16795	COG1027	Aspartate ammonia-lyase
O0R49_16810	COG2217	Heavy metal translocating P-type atpase
O0R49_16815	COG2608	mercury ion transmembrane transporter activity
O0R49_16820	COG1937	Protein conserved in bacteria
O0R49_16850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O0R49_16855	COG0557	exoribonuclease II activity
O0R49_16860	COG1647	Serine aminopeptidase, S33
O0R49_16865	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
O0R49_16870	COG2002	toxin-antitoxin pair type II binding
O0R49_16875	COG1476	TRANSCRIPTIONal
O0R49_16880	COG1396	sequence-specific DNA binding
O0R49_16885	COG1396	sequence-specific DNA binding
O0R49_16890	COG1733	regulation of RNA biosynthetic process
O0R49_16895	COG1174	glycine betaine transport
O0R49_16900	COG1732	Glycine betaine
O0R49_16905	COG1174	glycine betaine transport
O0R49_16910	COG0517	IMP dehydrogenase activity
O0R49_16910	COG1125	glycine betaine transport
O0R49_16915	COG1510	regulation of RNA biosynthetic process
O0R49_16920	COG2095	MarC family integral membrane protein
O0R49_16930	COG0456	acetyltransferase
O0R49_16950	COG1122	ATPase activity
O0R49_16960	COG0148	phosphopyruvate hydratase activity
O0R49_16965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
O0R49_16970	COG0149	triose-phosphate isomerase activity
O0R49_16975	COG0126	phosphoglycerate kinase activity
O0R49_16980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O0R49_16985	COG2390	Transcriptional regulator
O0R49_16990	COG0833	amino acid
O0R49_16995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O0R49_17000	COG3829	transcription factor binding
O0R49_17005	COG2186	Transcriptional regulator
O0R49_17010	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
O0R49_17020	COG0534	Mate efflux family protein
O0R49_17030	COG0444	Belongs to the ABC transporter superfamily
O0R49_17035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O0R49_17040	COG0601	transmembrane transport
O0R49_17045	COG0747	negative chemotaxis
O0R49_17050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R49_17055	COG0110	maltose O-acetyltransferase activity
O0R49_17060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
O0R49_17065	COG2244	polysaccharide biosynthetic process
O0R49_17070	COG5039	Polysaccharide pyruvyl transferase
O0R49_17075	COG1216	Glycosyl transferase, family 2
O0R49_17085	COG0438	transferase activity, transferring glycosyl groups
O0R49_17090	COG1215	transferase activity, transferring glycosyl groups
O0R49_17095	COG0438	transferase activity, transferring glycosyl groups
O0R49_17100	COG1086	Polysaccharide biosynthesis protein
O0R49_17105	COG0489	protein tyrosine kinase activity
O0R49_17110	COG3944	biosynthesis protein
O0R49_17115	COG1396	sequence-specific DNA binding
O0R49_17125	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_17130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_17135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_17140	COG0726	polysaccharide deacetylase
O0R49_17145	COG0488	(ABC) transporter
O0R49_17150	COG1819	glycosyl
O0R49_17165	COG0740	serine-type endopeptidase activity
O0R49_17170	COG1611	Belongs to the LOG family
O0R49_17175	COG1694	Mazg nucleotide pyrophosphohydrolase
O0R49_17180	COG0659	secondary active sulfate transmembrane transporter activity
O0R49_17185	COG0288	reversible hydration of carbon dioxide
O0R49_17190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
O0R49_17200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
O0R49_17205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_17210	COG1481	regulation of sporulation
O0R49_17215	COG0391	Required for morphogenesis under gluconeogenic growth conditions
O0R49_17220	COG1660	Displays ATPase and GTPase activities
O0R49_17225	COG1051	belongs to the nudix hydrolase family
O0R49_17230	COG0492	ferredoxin-NADP+ reductase activity
O0R49_17235	COG0791	NLP P60 protein
O0R49_17235	COG3883	PFAM NLP P60 protein
O0R49_17240	COG0457	Tetratricopeptide repeat
O0R49_17245	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O0R49_17245	COG0140	phosphoribosyl-ATP diphosphatase activity
O0R49_17250	COG0107	imidazoleglycerol-phosphate synthase activity
O0R49_17255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O0R49_17260	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O0R49_17265	COG0131	Imidazoleglycerol-phosphate dehydratase
O0R49_17270	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O0R49_17275	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O0R49_17280	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
O0R49_17285	COG4990	cell redox homeostasis
O0R49_17295	COG2910	NAD(P)H-binding
O0R49_17300	COG1959	2 iron, 2 sulfur cluster binding
O0R49_17305	COG0110	maltose O-acetyltransferase activity
O0R49_17310	COG0546	phosphoglycolate phosphatase activity
O0R49_17315	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
O0R49_17320	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O0R49_17325	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
O0R49_17330	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O0R49_17335	COG0363	glucosamine-6-phosphate deaminase activity
O0R49_17340	COG2188	Transcriptional regulator
O0R49_17345	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O0R49_17350	COG1950	PFAM Membrane protein of
O0R49_17355	COG1983	PspC domain protein
O0R49_17360	COG3595	metallopeptidase activity
O0R49_17375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O0R49_17385	COG4897	Protein conserved in bacteria
O0R49_17390	COG0574	Belongs to the PEP-utilizing enzyme family
O0R49_17390	COG3848	Pyruvate phosphate dikinase
O0R49_17395	COG1309	transcriptional regulator
O0R49_17400	COG2814	Major facilitator Superfamily
O0R49_17410	COG0745	RESPONSE REGULATOR receiver
O0R49_17415	COG5002	protein histidine kinase activity
O0R49_17420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O0R49_17425	COG0463	Glycosyl transferase, family 2
O0R49_17430	COG1113	amino acid transport
O0R49_17435	COG0778	Nitroreductase
O0R49_17440	COG1733	regulation of RNA biosynthetic process
O0R49_17445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R49_17455	COG0793	Belongs to the peptidase S41A family
O0R49_17455	COG3409	Peptidoglycan-binding domain 1 protein
O0R49_17460	COG0730	response to heat
O0R49_17465	COG0791	NLP P60 protein
O0R49_17465	COG3883	PFAM NLP P60 protein
O0R49_17470	COG2177	Part of the ABC transporter FtsEX involved in
O0R49_17475	COG2884	Cell division ATP-binding protein ftsE
O0R49_17480	COG2010	Cytochrome c
O0R49_17485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
O0R49_17505	COG0653	protein targeting
O0R49_17510	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O0R49_17515	COG0840	transmembrane signaling receptor activity
O0R49_17530	COG1516	flagellar protein fliS
O0R49_17535	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
O0R49_17540	COG1334	flagellar protein FlaG
O0R49_17545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
O0R49_17550	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
O0R49_17560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
O0R49_17565	COG1256	bacterial-type flagellum assembly
O0R49_17565	COG4786	Flagellar basal body rod
O0R49_17570	COG3418	PFAM FlgN family protein
O0R49_17585	COG1040	competence protein
O0R49_17595	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
O0R49_17600	COG1307	EDD domain protein, DegV family
O0R49_17605	COG2197	response regulator
O0R49_17610	COG4585	Histidine kinase
O0R49_17615	COG1739	Uncharacterized protein family UPF0029
O0R49_17620	COG1316	TRANSCRIPTIONal
O0R49_17625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O0R49_17630	COG0438	transferase activity, transferring glycosyl groups
O0R49_17635	COG1215	transferase activity, transferring glycosyl groups
O0R49_17640	COG3206	protein involved in exopolysaccharide biosynthesis
O0R49_17645	COG3307	-O-antigen
O0R49_17650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O0R49_17655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O0R49_17660	COG0438	transferase activity, transferring glycosyl groups
O0R49_17660	COG0297	glycogen (starch) synthase activity
O0R49_17665	COG2244	polysaccharide biosynthetic process
O0R49_17680	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_17680	COG2247	cell wall binding repeat
O0R49_17685	COG0860	N-Acetylmuramoyl-L-alanine amidase
O0R49_17685	COG2247	cell wall binding repeat
O0R49_17690	COG2247	cell wall binding repeat
O0R49_17690	COG2385	sporulation resulting in formation of a cellular spore
O0R49_17700	COG1316	TRANSCRIPTIONal
O0R49_17705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
O0R49_17710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O0R49_17715	COG1134	teichoic acid transport
O0R49_17720	COG1682	transport, permease protein
O0R49_17730	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R49_17735	COG0438	transferase activity, transferring glycosyl groups
O0R49_17740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
O0R49_17745	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O0R49_17750	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R49_17755	COG4193	domain, Protein
O0R49_17760	COG1482	cell wall glycoprotein biosynthetic process
O0R49_17770	COG1175	transmembrane transport
O0R49_17775	COG1653	transport
O0R49_17780	COG2197	response regulator
O0R49_17785	COG2972	Histidine kinase
O0R49_17795	COG0454	-acetyltransferase
O0R49_17800	COG0800	Aldolase
O0R49_17805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R49_17810	COG1609	Transcriptional regulator
O0R49_17815	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
O0R49_17820	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_17825	COG0697	spore germination
O0R49_17830	COG0814	amino acid
O0R49_17845	COG2814	Major facilitator Superfamily
O0R49_17850	COG1316	TRANSCRIPTIONal
O0R49_17855	COG0561	phosphatase activity
O0R49_17860	COG0791	NLP P60 protein
O0R49_17870	COG2843	Capsule synthesis protein
O0R49_17880	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O0R49_17885	COG0697	spore germination
O0R49_17900	COG1609	Transcriptional regulator
O0R49_17905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O0R49_17910	COG1869	D-ribose catabolic process
O0R49_17915	COG1129	ABC transporter
O0R49_17920	COG1172	Belongs to the binding-protein-dependent transport system permease family
O0R49_17925	COG1879	ABC-type sugar transport system periplasmic component
O0R49_17930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O0R49_17935	COG0583	DNA-binding transcription factor activity
O0R49_17940	COG0028	Belongs to the TPP enzyme family
O0R49_17945	COG3527	Alpha-acetolactate decarboxylase
O0R49_17950	COG1522	sequence-specific DNA binding
O0R49_17955	COG2059	Chromate
O0R49_17960	COG2059	Chromate
O0R49_17965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O0R49_17975	COG4715	Zinc finger, swim domain protein
O0R49_17980	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O0R49_17985	COG1366	Belongs to the anti-sigma-factor antagonist family
O0R49_17985	COG2202	Pas domain
O0R49_17990	COG0561	phosphatase activity
O0R49_18005	COG1970	mechanosensitive ion channel activity
O0R49_18010	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
O0R49_18015	COG0457	Tetratricopeptide repeat
O0R49_18020	COG4786	Flagellar basal body rod
O0R49_18025	COG4786	Flagellar basal body rod
O0R49_18030	COG1077	Cell shape determining protein MreB Mrl
O0R49_18035	COG1609	Transcriptional regulator
O0R49_18040	COG1846	Transcriptional regulator
O0R49_18045	COG2814	Major facilitator Superfamily
O0R49_18050	COG0671	phosphoesterase, PA-phosphatase related
O0R49_18055	COG0477	Major facilitator Superfamily
O0R49_18060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_18065	COG0765	amino acid transport
O0R49_18075	COG0004	ammonium transporteR
O0R49_18080	COG0347	Belongs to the P(II) protein family
O0R49_18085	COG0739	heme binding
O0R49_18090	COG1247	-acetyltransferase
O0R49_18130	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O0R49_18135	COG0523	cobalamin synthesis protein
O0R49_18140	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O0R49_18145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O0R49_18150	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O0R49_18155	COG2223	nitrite transmembrane transporter activity
O0R49_18160	COG0243	molybdopterin cofactor binding
O0R49_18165	COG2304	oxidoreductase activity
O0R49_18170	COG2304	oxidoreductase activity
O0R49_18175	COG2385	sporulation resulting in formation of a cellular spore
O0R49_18180	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O0R49_18190	COG4836	Membrane
O0R49_18200	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O0R49_18205	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O0R49_18210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O0R49_18215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O0R49_18220	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O0R49_18225	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O0R49_18230	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O0R49_18235	COG0356	it plays a direct role in the translocation of protons across the membrane
O0R49_18245	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O0R49_18250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O0R49_18255	COG4475	Protein of unknown function (DUF436)
O0R49_18260	COG0698	ribose 5-phosphate isomerase
O0R49_18265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O0R49_18270	COG1971	Probably functions as a manganese efflux pump
O0R49_18275	COG0009	L-threonylcarbamoyladenylate synthase
O0R49_18280	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O0R49_18295	COG2890	protein-(glutamine-N5) methyltransferase activity
O0R49_18300	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O0R49_18305	COG0789	Transcriptional regulator
O0R49_18310	COG0679	Auxin Efflux Carrier
O0R49_18315	COG0281	malic enzyme
O0R49_18320	COG1435	thymidine kinase activity
O0R49_18325	COG0254	rRNA binding
O0R49_18330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
O0R49_18335	COG1494	fructose-1,6-bisphosphatase
O0R49_18340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O0R49_18345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O0R49_18350	COG0191	fructose-bisphosphate aldolase activity
O0R49_18355	COG2204	response regulator
O0R49_18360	COG4821	SIS domain
O0R49_18365	COG0504	CTP synthase activity
O0R49_18370	COG3343	RNA polymerase activity
O0R49_18380	COG1960	acyl-CoA dehydrogenase activity
O0R49_18385	COG1960	acyl-CoA dehydrogenase activity
O0R49_18390	COG1250	3-hydroxyacyl-CoA dehydrogenase
O0R49_18395	COG0183	Belongs to the thiolase family
O0R49_18400	COG0247	lactate metabolic process
O0R49_18400	COG2181	nitrate reductase activity
O0R49_18405	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R49_18410	COG4294	response to UV
O0R49_18420	COG1619	proteins homologs of microcin C7 resistance protein MccF
O0R49_18430	COG1132	(ABC) transporter
O0R49_18435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O0R49_18440	COG1619	proteins homologs of microcin C7 resistance protein MccF
O0R49_18445	COG0018	arginyl-trna synthetase
O0R49_18450	COG4506	Protein conserved in bacteria
O0R49_18460	COG0010	Belongs to the arginase family
O0R49_18465	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
O0R49_18470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O0R49_18480	COG1994	Peptidase M50
O0R49_18485	COG1942	4-Oxalocrotonate Tautomerase
O0R49_18495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_18500	COG0583	DNA-binding transcription factor activity
O0R49_18505	COG0431	NADPH-dependent FMN reductase
O0R49_18510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_18515	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
O0R49_18520	COG0454	-acetyltransferase
O0R49_18525	COG0765	amino acid transport
O0R49_18530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_18540	COG1126	abc transporter atp-binding protein
O0R49_18545	COG3465	dGTPase activity
O0R49_18550	COG1078	dGTPase activity
O0R49_18555	COG4844	belongs to the
O0R49_18605	COG5444	nuclease activity
O0R49_18635	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O0R49_18645	COG0280	phosphate acetyltransferase
O0R49_18655	COG2814	Major facilitator Superfamily
O0R49_18660	COG1522	sequence-specific DNA binding
O0R49_18665	COG2814	Major facilitator Superfamily
O0R49_18670	COG0077	Prephenate dehydratase
O0R49_18680	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_18685	COG0151	Belongs to the GarS family
O0R49_18690	COG0436	Aminotransferase
O0R49_18695	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_18700	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
O0R49_18705	COG1091	dTDP-4-dehydrorhamnose reductase activity
O0R49_18710	COG1088	dTDP-glucose 4,6-dehydratase activity
O0R49_18715	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O0R49_18720	COG3980	spore coat polysaccharide biosynthesis protein
O0R49_18725	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
O0R49_18730	COG2089	acid synthase
O0R49_18740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O0R49_18745	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
O0R49_18750	COG0463	Glycosyl transferase, family 2
O0R49_18770	COG2363	Small membrane protein
O0R49_18775	COG2233	PERMEase
O0R49_18785	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_18790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O0R49_18795	COG1216	Glycosyl transferase, family 2
O0R49_18805	COG0351	phosphomethylpyrimidine kinase
O0R49_18825	COG3964	amidohydrolase
O0R49_18835	COG1621	beta-fructofuranosidase activity
O0R49_18840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_18840	COG1263	PTS System
O0R49_18845	COG3711	transcriptional antiterminator
O0R49_18855	COG1404	Belongs to the peptidase S8 family
O0R49_18860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O0R49_18865	COG0778	Nitroreductase
O0R49_18870	COG0772	Belongs to the SEDS family
O0R49_18880	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
O0R49_18885	COG1845	cytochrome c oxidase, subunit III
O0R49_18890	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O0R49_18895	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O0R49_18905	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
O0R49_18910	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
O0R49_18915	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O0R49_18930	COG2246	polysaccharide biosynthetic process
O0R49_18950	COG3162	membrane
O0R49_18955	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O0R49_18965	COG0352	thiamine-phosphate diphosphorylase activity
O0R49_18970	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O0R49_18975	COG0583	DNA-binding transcription factor activity
O0R49_18980	COG1380	Effector of murein hydrolase LrgA
O0R49_18985	COG1346	cytolysis
O0R49_18990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
O0R49_18995	COG0346	lactoylglutathione lyase activity
O0R49_19005	COG0765	amino acid transport
O0R49_19010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O0R49_19015	COG0457	Tetratricopeptide repeat
O0R49_19025	COG2357	RelA SpoT domain protein
O0R49_19030	COG1172	Belongs to the binding-protein-dependent transport system permease family
O0R49_19035	COG1129	ABC transporter
O0R49_19045	COG3420	alginic acid biosynthetic process
O0R49_19050	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O0R49_19060	COG1486	melibiose metabolic process
O0R49_19065	COG1447	Phosphotransferase system cellobiose-specific component IIA
O0R49_19070	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R49_19075	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R49_19080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_19080	COG3711	transcriptional antiterminator
O0R49_19100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O0R49_19115	COG1595	DNA-templated transcription, initiation
O0R49_19125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O0R49_19130	COG4988	ABC transporter
O0R49_19135	COG1294	oxidase, subunit
O0R49_19140	COG1271	oxidase subunit
O0R49_19155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O0R49_19165	COG4509	Sortase family
O0R49_19190	COG5386	Cell surface protein
O0R49_19195	COG5386	Cell surface protein
O0R49_19200	COG1733	regulation of RNA biosynthetic process
O0R49_19205	COG2514	catechol 2,3-dioxygenase activity
O0R49_19210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0R49_19210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O0R49_19215	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0R49_19215	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
O0R49_19225	COG0726	polysaccharide deacetylase
O0R49_19230	COG1447	Phosphotransferase system cellobiose-specific component IIA
O0R49_19235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R49_19240	COG2723	6-phospho-beta-galactosidase activity
O0R49_19245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
O0R49_19250	COG3711	transcriptional antiterminator
O0R49_19250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
O0R49_19275	COG1757	Na H antiporter
O0R49_19280	COG1027	Aspartate ammonia-lyase
O0R49_19285	COG0252	asparaginase activity
O0R49_19290	COG1396	sequence-specific DNA binding
O0R49_19315	COG4842	Belongs to the WXG100 family
O0R49_19320	COG2195	Cleaves the N-terminal amino acid of tripeptides
O0R49_19335	COG1737	Transcriptional regulator
O0R49_19340	COG2084	Dehydrogenase
O0R49_19350	COG2610	gluconate transmembrane transporter activity
O0R49_19355	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O0R49_19360	COG2723	6-phospho-beta-galactosidase activity
O0R49_19365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_19365	COG1263	PTS System
O0R49_19365	COG2190	(PTS) system
O0R49_19370	COG3711	transcriptional antiterminator
O0R49_19375	COG3878	Protein conserved in bacteria
O0R49_19385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O0R49_19390	COG1122	ATPase activity
O0R49_19395	COG4721	ABC-type cobalt transport system, permease component
O0R49_19400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O0R49_19435	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
O0R49_19440	COG0778	Nitroreductase
O0R49_19450	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
O0R49_19455	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
O0R49_19460	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O0R49_19465	COG2390	Transcriptional regulator
O0R49_19475	COG2755	lipolytic protein G-D-S-L family
O0R49_19475	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
O0R49_19495	COG0561	phosphatase activity
O0R49_19500	COG0789	Transcriptional regulator
O0R49_19505	COG0673	inositol 2-dehydrogenase activity
O0R49_19510	COG0840	transmembrane signaling receptor activity
O0R49_19515	COG1113	amino acid transport
O0R49_19520	COG4335	DNA alkylation repair
O0R49_19530	COG1070	Carbohydrate kinase
O0R49_19535	COG1737	Transcriptional regulator
O0R49_19570	COG0583	DNA-binding transcription factor activity
O0R49_19575	COG1609	Transcriptional regulator
O0R49_19580	COG2182	Extracellular solute-binding protein
O0R49_19585	COG1175	transmembrane transport
O0R49_19590	COG3833	ABC-type maltose transport systems, permease component
O0R49_19600	COG1874	Beta-galactosidase
O0R49_19605	COG2851	Citrate transporter
O0R49_19615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
O0R49_19620	COG1131	(ABC) transporter
O0R49_19625	COG2824	Alkylphosphonate utilization operon protein PhnA
O0R49_19630	COG1929	Belongs to the glycerate kinase type-1 family
O0R49_19635	COG2610	gluconate transmembrane transporter activity
O0R49_19640	COG3835	regulator
O0R49_19645	COG1309	transcriptional regulator
O0R49_19650	COG2814	Major facilitator Superfamily
O0R49_19660	COG1136	(ABC) transporter
O0R49_19660	COG0577	efflux transmembrane transporter activity
O0R49_19670	COG0457	Tetratricopeptide repeat
O0R49_19675	COG3711	transcriptional antiterminator
O0R49_19680	COG2723	6-phospho-beta-galactosidase activity
O0R49_19685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_19685	COG1263	PTS System
O0R49_19685	COG2190	(PTS) system
O0R49_19720	COG1113	amino acid transport
O0R49_19725	COG1609	Transcriptional regulator
O0R49_19730	COG2814	Major facilitator Superfamily
O0R49_19740	COG2814	Major facilitator Superfamily
O0R49_19745	COG2723	6-phospho-beta-galactosidase activity
O0R49_19755	COG1263	PTS System
O0R49_19755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O0R49_19755	COG2190	(PTS) system
O0R49_19770	COG1012	belongs to the aldehyde dehydrogenase family
O0R49_19790	COG0163	prenyltransferase activity
O0R49_19795	COG0583	DNA-binding transcription factor activity
O0R49_19800	COG2723	6-phospho-beta-galactosidase activity
O0R49_19810	COG2188	Transcriptional regulator
O0R49_19825	COG0384	phenazine biosynthesis protein PhzF
O0R49_19830	COG0583	DNA-binding transcription factor activity
O0R49_19855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O0R49_19865	COG2814	Major facilitator Superfamily
O0R49_19870	COG0640	Transcriptional regulator
O0R49_19880	COG1234	tRNA 3'-trailer cleavage
O0R49_19900	COG1404	Belongs to the peptidase S8 family
O0R49_19920	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
O0R49_19930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O0R49_19940	COG4720	Psort location CytoplasmicMembrane, score
O0R49_19960	COG0456	acetyltransferase
O0R49_19965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O0R49_19970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
O0R49_19975	COG4853	Protein conserved in bacteria
O0R49_19980	COG4863	YycH protein
O0R49_19985	COG5002	protein histidine kinase activity
O0R49_19990	COG0745	RESPONSE REGULATOR receiver
O0R49_20015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O0R49_20025	COG2311	Membrane
O0R49_20030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O0R49_20035	COG1309	transcriptional regulator
O0R49_20040	COG2124	cytochrome p450
O0R49_20045	COG0346	lactoylglutathione lyase activity
O0R49_20050	COG0305	Participates in initiation and elongation during chromosome replication
O0R49_20075	COG2819	hydrolase of the alpha beta superfamily
O0R49_20080	COG1028	Short-chain dehydrogenase reductase Sdr
O0R49_20085	COG1169	isochorismate synthase
O0R49_20090	COG1021	2,3-dihydroxybenzoate-AMP ligase
O0R49_20095	COG1535	isochorismatase
O0R49_20095	COG3433	isochorismatase activity
O0R49_20100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O0R49_20105	COG3251	PFAM MbtH domain protein
O0R49_20110	COG2207	Transcriptional regulator
O0R49_20110	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_20115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O0R49_20120	COG2819	hydrolase of the alpha beta superfamily
O0R49_20125	COG3093	addiction module antidote protein HigA
O0R49_20130	COG2807	transmembrane transport
O0R49_20135	COG0359	binds to the 23S rRNA
O0R49_20140	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
O0R49_20145	COG4241	membrane
O0R49_20150	COG1227	inorganic diphosphatase activity
O0R49_20160	COG1595	DNA-templated transcription, initiation
O0R49_20170	COG0753	catalase activity
O0R49_20175	COG0655	NAD(P)H dehydrogenase (quinone) activity
O0R49_20180	COG0400	carboxylic ester hydrolase activity
O0R49_20185	COG0346	lactoylglutathione lyase activity
O0R49_20190	COG1174	glycine betaine transport
O0R49_20195	COG1125	glycine betaine transport
O0R49_20195	COG0517	IMP dehydrogenase activity
O0R49_20200	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O0R49_20205	COG0629	single-stranded DNA binding
O0R49_20210	COG0360	Binds together with S18 to 16S ribosomal RNA
O0R49_20215	COG0012	GTP binding
O0R49_20220	COG4481	Protein conserved in bacteria
O0R49_20235	COG3949	Membrane
O0R49_20245	COG1475	DNA binding
O0R49_20250	COG1192	Involved in chromosome partitioning
O0R49_20255	COG1475	DNA binding
O0R49_20260	COG0357	Ribosomal RNA small subunit methyltransferase G
O0R49_20265	COG0445	tRNA wobble uridine modification
O0R49_20270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
O0R49_20275	COG1847	R3H domain protein
O0R49_20280	COG0706	membrane insertase activity
O0R49_20285	COG0594	ribonuclease P activity
O0R49_20290	COG0230	Belongs to the bacterial ribosomal protein bL34 family