locus-tag class description FX981_00002 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) FX981_00003 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) FX981_00004 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) FX981_00005 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) FX981_00006 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FX981_00007 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FX981_00008 ENOG4105CD3 dihydroorotase FX981_00009 ENOG4105CXT aspartate transcarbamylase FX981_00011 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) FX981_00012 ENOG4105C34 Pseudouridine synthase FX981_00013 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) FX981_00015 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FX981_00017 ENOG4105DBK s4 domain protein FX981_00018 ENOG41067XK integral membrane protein FX981_00019 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) FX981_00020 ENOG4105DFA alanine racemase domain protein FX981_00021 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FX981_00022 ENOG4105WR5 sporulation protein, YlmC YmxH family FX981_00023 ENOG4105DKW ABC transporter FX981_00024 ENOG4105VI0 Pts system, glucitol sorbitol-specific FX981_00025 ENOG4105DZY Pts system, glucitol sorbitol-specific FX981_00026 ENOG410787A Pts system, glucitol sorbitol-specific FX981_00029 ENOG4105DKT Transcriptional regulator FX981_00031 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX981_00032 ENOG4105FFI sigma-e processing peptidase spoiiga FX981_00034 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FX981_00035 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FX981_00036 ENOG4105K67 small basic protein FX981_00038 ENOG4108R2U division initiation protein FX981_00039 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) FX981_00040 ENOG4105D4A Cell wall formation (By similarity) FX981_00041 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) FX981_00042 ENOG4105CNI cell division protein FtsW FX981_00043 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FX981_00044 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) FX981_00045 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FX981_00046 ENOG4105CJN penicillin-binding protein FX981_00047 ENOG4105CJN penicillin-binding protein FX981_00049 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) FX981_00050 ENOG4108V6E Cell division protein mraZ FX981_00055 ENOG41067VY 50S ribosomal protein L32 FX981_00056 ENOG4105KNH Nucleic acid-binding protein FX981_00057 ENOG4105CDE UPF0348 protein FX981_00058 ENOG41063PX domain protein FX981_00059 ENOG4105D78 K07001 NTE family protein FX981_00060 ENOG4105H20 Sporulation integral membrane protein YlbJ FX981_00061 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) FX981_00062 ENOG4106H78 methyltransferase FX981_00063 ENOG4105WUC UPF0298 protein FX981_00068 ENOG4106UY4 Inherit from COG: Scp-like extracellular FX981_00069 ENOG41080XQ Signal transduction protein with cbs domains FX981_00071 ENOG4105DQ6 Transposase FX981_00074 ENOG41064X9 cytochrome C oxidase subunit IV FX981_00075 ENOG4105CCU oxidase (Subunit III) FX981_00076 ENOG4105BZ9 Cytochrome C oxidase, subunit I FX981_00078 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) FX981_00080 ENOG4105CVP deoxyribo-dipyrimidine photolyase FX981_00081 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) FX981_00082 ENOG4105CNI cell division protein FtsW FX981_00084 ENOG4105CSV Glutaminase FX981_00086 ENOG4108IAB Phoh family FX981_00089 ENOG4105QA2 FX981_00090 ENOG4105CI3 gtp-binding protein typa FX981_00097 ENOG4105ECY inositol monophosphatase FX981_00099 ENOG4108WQ8 UPF0637 protein FX981_00101 ENOG4105CXN decarboxylase FX981_00103 ENOG4107QN2 dihydrolipoyl dehydrogenase FX981_00104 ENOG4105C7S Dehydrogenase FX981_00105 ENOG4105CPP Dehydrogenase, E1 component FX981_00109 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FX981_00110 ENOG4108X4Q Hydrolase FX981_00112 ENOG4105CN5 Metallo-Beta-Lactamase FX981_00113 ENOG4105CPN adenine deaminase FX981_00114 ENOG4107ZYR domain protein FX981_00116 ENOG4105BZU Histidine kinase FX981_00121 ENOG4105C5H ABC transporter FX981_00124 ENOG4105DM4 PTS System FX981_00125 ENOG4105DE4 1-phosphofructokinase FX981_00126 ENOG4105E98 transcriptional regulator DeoR family FX981_00127 ENOG4107RBB ABC transporter, permease FX981_00128 ENOG4105C19 ABC transporter FX981_00129 ENOG4107X8C Efflux transporter RND family MFP subunit FX981_00132 ENOG41067WU Molybdopterin converting factor (Subunit 1) FX981_00133 ENOG4108ZAF Molybdopterin FX981_00134 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein FX981_00135 ENOG4105CVM Molybdenum cofactor synthesis domain protein FX981_00136 ENOG4105D06 uba thif-type nad fad binding protein FX981_00137 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FX981_00140 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FX981_00141 ENOG4105D3R alkyl hydroperoxide reductase FX981_00142 ENOG4105D8X mechanosensitive ion channel FX981_00143 ENOG4106AUC UPF0180 protein FX981_00145 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) FX981_00146 ENOG4105NQC Flavodoxin FX981_00152 ENOG4108XRC Protein of unknown function (DUF458) FX981_00153 ENOG4107IN1 Protein of unknown function (DUF1797) FX981_00154 ENOG4105WEF catalase FX981_00155 ENOG4105EPM Diguanylate phosphodiesterase FX981_00156 ENOG4105K6S Short-chain dehydrogenase reductase Sdr FX981_00158 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein FX981_00161 ENOG4108UZ3 Transporter FX981_00162 ENOG4108MCI Transcriptional regulator, ARAC family FX981_00177 ENOG4105CDU Replicative dna helicase FX981_00178 ENOG4105UIN FX981_00179 ENOG4107R88 Chemotaxis protein (CheV) FX981_00181 ENOG41085PJ rdd domain containing protein FX981_00184 ENOG4105CHM Aminotransferase FX981_00185 ENOG4105BZU Histidine kinase FX981_00187 ENOG4105K4I Scp-like extracellular FX981_00188 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FX981_00189 ENOG4105CHR reductase FX981_00190 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer FX981_00191 ENOG4105F6S Spore photoproduct lyase FX981_00193 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FX981_00194 ENOG4105KRI phosphocarrier protein (HPr FX981_00196 ENOG4105CID antiterminator FX981_00198 ENOG4105DC7 peptidase M24 FX981_00199 ENOG4105C59 p-type ATPase FX981_00202 ENOG4105F0V Cell wall hydrolase FX981_00207 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr FX981_00209 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) FX981_00210 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FX981_00211 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase FX981_00212 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) FX981_00213 ENOG4108K88 Membrane FX981_00216 ENOG4105E14 MotA TolQ exbB proton channel FX981_00217 ENOG4105ER2 Ompa motb domain protein FX981_00218 ENOG41090MY MarR family Transcriptional regulator FX981_00219 ENOG4105BZU Histidine kinase FX981_00221 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) FX981_00222 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) FX981_00223 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) FX981_00224 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate FX981_00226 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) FX981_00227 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) FX981_00229 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FX981_00230 ENOG4105BZU Histidine kinase FX981_00231 ENOG4108TGC Acyltransferase FX981_00234 ENOG410900G Protein of unknown function (DUF421) FX981_00236 ENOG4105D0M Protease HtpX homolog FX981_00238 ENOG410681C small acid-soluble spore protein FX981_00240 ENOG4108WZW RNA polymerase sigma FX981_00241 ENOG4107TS3 membrane protein, TerC FX981_00242 ENOG4107T5V SNARE associated Golgi FX981_00243 ENOG4105BZU Histidine kinase FX981_00246 ENOG4105V75 Transcriptional regulator FX981_00248 ENOG4105CJW magnesium transporter FX981_00250 ENOG4106849 propeptide, pepSY amd peptidase M4 FX981_00252 ENOG41062D9 Histidine kinase FX981_00253 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX981_00254 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_00255 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FX981_00256 ENOG4107Y2X deaminase FX981_00257 ENOG4108ZHJ Organic hydroperoxide resistance protein FX981_00258 ENOG4105K56 Transcriptional regulator FX981_00263 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FX981_00264 ENOG4105CIY formyltetrahydrofolate deformylase FX981_00266 ENOG41080TC multidrug resistance protein FX981_00267 ENOG410839T multidrug resistance protein FX981_00269 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FX981_00270 ENOG4108428 Inherit from COG: -acetyltransferase FX981_00273 ENOG4105K7K Transcriptional regulator FX981_00274 ENOG4108S4H thioesterase Superfamily protein FX981_00275 ENOG4107TUM Amidinotransferase FX981_00276 ENOG4108JQ7 (ABC) transporter FX981_00277 ENOG4107SN7 NLP P60 protein FX981_00278 ENOG4105DTQ mandelate racemase muconate lactonizing FX981_00279 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FX981_00281 ENOG4105C3U ABC transporter FX981_00282 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX981_00283 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX981_00284 ENOG4108ME1 Peptidase M55 D-aminopeptidase FX981_00286 ENOG4105C0H protease FX981_00288 ENOG4107R7I amino acid FX981_00290 ENOG4107RHR regulatoR FX981_00291 ENOG4105CHR reductase FX981_00292 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FX981_00294 ENOG4107QKR Dehydrogenase FX981_00295 ENOG4105CPP Dehydrogenase, E1 component FX981_00296 ENOG4107RUY (E1 component), alpha subunit FX981_00300 ENOG4105DT3 PTS system, galactitol-specific IIc component FX981_00302 ENOG4108IJ6 ABC transporter FX981_00303 ENOG4105ECW sulfate abc transporter FX981_00304 ENOG4108I5D sulfate abc transporter FX981_00305 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FX981_00306 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FX981_00308 ENOG4107GRR phosphate transport regulator FX981_00309 ENOG4105CJ3 phosphate transporter FX981_00313 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FX981_00314 ENOG410635T phage-like element pbsx protein FX981_00315 ENOG4105K7W phage-related replication protein FX981_00319 ENOG4105I03 Flagellin FX981_00320 ENOG4105I03 Flagellin FX981_00324 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FX981_00329 ENOG4107JM4 Tetratricopeptide repeat FX981_00331 ENOG4105DJ2 Major Facilitator Superfamily FX981_00332 ENOG4107V2S Transcriptional regulator FX981_00336 ENOG4105DUM transcriptional regulator, lysR family FX981_00352 ENOG4105I03 Flagellin FX981_00355 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) FX981_00363 ENOG4105C28 cystathionine FX981_00364 ENOG4105C28 cystathionine FX981_00367 ENOG41082BV acetyltransferase FX981_00369 ENOG4105ENA helicase FX981_00380 ENOG4107A88 FX981_00381 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FX981_00382 ENOG4105DWF phosphomethylpyrimidine kinase FX981_00383 ENOG4105D06 uba thif-type nad fad binding protein FX981_00384 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) FX981_00387 ENOG4108VEU Thiamine monophosphate synthase FX981_00388 ENOG4105ETU transcriptional activator (TenA FX981_00390 ENOG4107S1Q Phosphatase FX981_00391 ENOG4105EMS pseudouridine synthase FX981_00392 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FX981_00394 ENOG4106EFP UPF0738 protein FX981_00395 ENOG4105MIX Adenylate cyclase FX981_00396 ENOG4105E4C Lytic transglycosylase catalytic FX981_00397 ENOG4108Z18 K06886 hemoglobin FX981_00398 ENOG4105T58 Dithiol-disulfide isomerase FX981_00400 ENOG4105DPN Oligoendopeptidase f FX981_00402 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FX981_00403 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis FX981_00404 ENOG4108ZCF integral membrane protein FX981_00405 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) FX981_00408 ENOG4108JQ7 (ABC) transporter FX981_00410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX981_00411 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX981_00412 ENOG4108J59 Extracellular solute-binding protein, family 5 FX981_00413 ENOG4105C31 Tryptophanyl-tRNA synthetase FX981_00415 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX981_00418 ENOG4108JQ7 (ABC) transporter FX981_00419 ENOG4105C3U ABC transporter FX981_00421 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FX981_00422 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) FX981_00425 ENOG4107RMD Basic membrane lipoprotein FX981_00431 ENOG4105DBV ornithine carbamoyltransferase FX981_00433 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FX981_00434 ENOG4105C8Y Acetylornithine aminotransferase FX981_00435 ENOG4105CAS nag kinase FX981_00437 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FX981_00439 ENOG4105IQ5 FAD linked oxidase domain protein FX981_00440 ENOG4105VG1 fes assembly suf system protein FX981_00441 ENOG4108MXZ Esterase FX981_00442 ENOG4108KP7 hydrolase FX981_00444 ENOG41073B9 FX981_00446 ENOG4107AYK membrAne FX981_00447 ENOG4105EPR degv family FX981_00448 ENOG4105C8Q Methyl-accepting chemotaxis FX981_00449 ENOG4105DIH basic membrane FX981_00450 ENOG4105QNR S1 RNA binding domain protein FX981_00451 ENOG4108VPT UPF0234 protein FX981_00459 ENOG4105DY8 decarboxylase FX981_00465 ENOG4106HBX Transcriptional Regulator AraC Family FX981_00466 ENOG4105UQX Mate efflux family protein FX981_00470 ENOG4105CAQ asparagine synthetase FX981_00472 ENOG4106BKT UPF0344 protein FX981_00473 ENOG4105ERH Fumarylacetoacetate hydrolase FX981_00484 ENOG4105EYH Exonuclease FX981_00486 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation FX981_00490 ENOG4105D0M Protease HtpX homolog FX981_00492 ENOG4108KK1 membrane protein AbrB duplication FX981_00495 ENOG41060YP FX981_00496 ENOG4108KGH TRANSCRIPTIONal FX981_00498 ENOG4108IPW abc transporter atp-binding protein FX981_00499 ENOG4105CM4 permease protein FX981_00500 ENOG4105DHS permease protein FX981_00501 ENOG41067XF inhibitor FX981_00502 ENOG4105E5M Multidrug resistance protein D FX981_00503 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FX981_00505 ENOG4105XVF Competence transcription factor FX981_00509 ENOG4106YBV Methyl-accepting chemotaxis FX981_00510 ENOG4107TB6 phosphoglycerate mutase FX981_00512 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 FX981_00514 ENOG4105CEY Amp-dependent synthetase and ligase FX981_00515 ENOG4105DF9 Lipoate-protein, ligase FX981_00516 ENOG4108RQ5 Beta-lactamase domain-containing protein FX981_00517 ENOG4106AXD FX981_00519 ENOG4105DER m42 family FX981_00520 ENOG4105ECB domain protein FX981_00522 ENOG4105C1Q protoporphyrinogen oxidase FX981_00523 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) FX981_00524 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) FX981_00525 ENOG4105BZ4 penicillin-binding protein FX981_00526 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation FX981_00532 ENOG4105K59 histidine triad (HIT) protein FX981_00533 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) FX981_00534 ENOG4105NBU tryptophan transport protein FX981_00541 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) FX981_00545 ENOG4106D4I domain protein FX981_00546 ENOG4107VRP DNA repair exonuclease FX981_00548 ENOG4105CGU Enoyl-CoA hydratase FX981_00550 ENOG4105NCW Trka-c domain protein FX981_00551 ENOG4107S91 Sodium hydrogen exchanger FX981_00553 ENOG4105D4P Coproporphyrinogen iii oxidase FX981_00555 ENOG4105WZB UPF0342 protein FX981_00556 ENOG4108UH6 UPF0754 membrane protein FX981_00558 ENOG410839P FX981_00565 ENOG4105BZ1 (ABC) transporter FX981_00566 ENOG4105BZ1 (ABC) transporter FX981_00568 ENOG4105F0I Aminotransferase FX981_00569 ENOG4107VMI polysaccharide deacetylase FX981_00570 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FX981_00571 ENOG4105D64 Mechanosensitive ion channel FX981_00572 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FX981_00573 ENOG4105WMR Protein CrcB homolog FX981_00576 ENOG4105C37 (CBS) domain FX981_00578 ENOG4105C37 (CBS) domain FX981_00579 ENOG4105F6E Acyl-transferase FX981_00580 ENOG4108AEY RNA polymerase sigma factor FX981_00581 ENOG4105J37 FX981_00583 ENOG4105CUB amino acid FX981_00585 ENOG4105G6Z alkaline phosphatase FX981_00586 ENOG4105ED1 spovr family FX981_00587 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FX981_00588 ENOG4105KPV Transcriptional regulator FX981_00589 ENOG4105CH6 catalase FX981_00592 ENOG4105WH1 Two component transcriptional regulator luxr family FX981_00593 ENOG4105BZU Histidine kinase FX981_00595 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FX981_00596 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) FX981_00598 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FX981_00599 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FX981_00600 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FX981_00603 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FX981_00604 ENOG4107YBY Hydrolase FX981_00606 ENOG4108YBP pseudouridine synthase FX981_00609 ENOG4105BZU Histidine kinase FX981_00615 ENOG4105BZU Histidine kinase FX981_00616 ENOG4105VEQ Cold shock protein FX981_00619 ENOG4105CS1 NAD(P)H quinone oxidoreductase FX981_00620 ENOG4105C0R drug resistance transporter emrb qaca subfamily FX981_00621 ENOG4105CW7 secretion protein, HlyD family FX981_00622 ENOG4106AKX UPF0229 protein FX981_00623 ENOG4105CYN Serine protein kinase FX981_00624 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FX981_00626 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FX981_00633 ENOG4105CJ1 ABC, transporter FX981_00636 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FX981_00637 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein FX981_00638 ENOG4105E2Y ABC, transporter FX981_00642 ENOG4105E0M Sulfatase FX981_00673 ENOG4105G5W regulator Fur family FX981_00674 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FX981_00675 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FX981_00676 ENOG4107NBY Membrane FX981_00677 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX981_00678 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX981_00679 ENOG4105DEF Extracellular solute-binding protein, family 5 FX981_00680 ENOG4108JQ7 (ABC) transporter FX981_00681 ENOG4105C3U ABC transporter FX981_00682 ENOG4105BZ1 (ABC) transporter FX981_00683 ENOG4105EVI UPF0374 protein FX981_00686 ENOG4105CAN Short-chain dehydrogenase reductase Sdr FX981_00687 ENOG4106BXE FX981_00688 ENOG4105CEN a g-specific adenine glycosylase FX981_00689 ENOG41067AE Membrane-bound metal-dependent hydrolase FX981_00699 ENOG4106DF4 Sigma-70, region 4 FX981_00701 ENOG4105F0F Oxalate decarboxylase FX981_00703 ENOG4105EJV Membrane FX981_00704 ENOG4105CKK Glycosyl transferase, family 2 FX981_00709 ENOG4105KC9 Modulates RecA activity (By similarity) FX981_00710 ENOG4105ECP epimerase FX981_00713 ENOG4107Y03 Nitroreductase FX981_00718 ENOG410834F Transcriptional regulator FX981_00720 ENOG4108YYS metal-dependent hydrolase (By similarity) FX981_00724 ENOG4105K6V RNA polymerase FX981_00725 ENOG4105KK4 UPF0060 membrane protein FX981_00727 ENOG4107TDE lipolytic protein G-D-S-L family FX981_00731 ENOG410839T multidrug resistance protein FX981_00741 ENOG4105C22 threonyL-tRNA synthetase FX981_00743 ENOG4108RWP Major Facilitator Superfamily protein FX981_00744 ENOG4107TXC Transcriptional regulator FX981_00745 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase FX981_00746 ENOG4105MDS 4-oxalocrotonate tautomerase FX981_00750 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FX981_00753 ENOG4105D7N magnesium and cobalt transport protein CorA FX981_00758 ENOG4105D8X mechanosensitive ion channel FX981_00760 ENOG4105CDY transcriptional regulatory protein FX981_00761 ENOG4106H3A restriction FX981_00763 ENOG4105UPD Calcium Proton FX981_00765 ENOG4108ISG Major Facilitator FX981_00766 ENOG4108Z9I -acetyltransferase FX981_00768 ENOG4107U9T Pfam:Ribonuclease_BN FX981_00770 ENOG4105KJF protein tyrosine phosphatase FX981_00771 ENOG4105BZG amino acid carrier protein FX981_00773 ENOG4107RKG DJ-1/PfpI family FX981_00774 ENOG4105CGH 5'-nucleotidase FX981_00776 ENOG4107414 GntR family transcriptional regulator FX981_00777 ENOG4105CG3 alpha amylase, catalytic region FX981_00778 ENOG4105C5Y PTS System FX981_00780 ENOG4105C8Q Methyl-accepting chemotaxis FX981_00781 ENOG4105DY8 decarboxylase FX981_00785 ENOG4105NX3 Membrane FX981_00787 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) FX981_00790 ENOG4108RPX mosc domain containing protein FX981_00791 ENOG41084AG Acylphosphatase FX981_00792 ENOG4107RSM transcriptional regulator FX981_00793 ENOG41080V3 Major Facilitator superfamily FX981_00795 ENOG4105U3E Transcriptional regulator FX981_00796 ENOG4105PY6 Phenolic acid decarboxylase FX981_00800 ENOG4108MRH transcriptional regulatory protein FX981_00803 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FX981_00805 ENOG4105E6M Sulphatase-modifying factor protein FX981_00806 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FX981_00810 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FX981_00813 ENOG4105FDU atp-dependent rna helicase FX981_00814 ENOG4105C5H ABC transporter FX981_00815 ENOG4105DXB Major Facilitator superfamily FX981_00816 ENOG4107SWG transcriptional regulator MERR family FX981_00817 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) FX981_00818 ENOG4105C5H ABC transporter FX981_00819 ENOG4106WTF Glycosyl transferase, family 2 FX981_00820 ENOG4105CUB amino acid FX981_00826 ENOG4105C8P )-transporter FX981_00827 ENOG4107RVG penicillin-binding protein FX981_00828 ENOG4105EU0 Major facilitator Superfamily FX981_00829 ENOG41090R9 glycosyltransferase FX981_00830 ENOG4107R51 Glycosyl transferase, family 2 FX981_00831 ENOG41090R9 glycosyltransferase FX981_00833 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase FX981_00834 ENOG4108R1P FX981_00836 ENOG4105DUM transcriptional regulator, lysR family FX981_00839 ENOG4105HX0 Transcriptional regulator FX981_00840 ENOG4105F8D glycoside hydrolase family 4 FX981_00843 ENOG4105C3M thioredoxin reductase FX981_00844 ENOG41062ES Transcriptional regulator FX981_00846 ENOG4105F8D glycoside hydrolase family 4 FX981_00847 ENOG4105CI1 PTS System FX981_00848 ENOG4108Q3X Transcriptional regulator FX981_00852 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FX981_00853 ENOG4105CBD Diacylglycerol kinase FX981_00854 ENOG4105DU0 nucleoside hydrolase FX981_00856 ENOG4108IG5 Transcriptional regulator FX981_00857 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FX981_00858 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) FX981_00859 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) FX981_00860 ENOG4105CK7 Sodium proline symporter FX981_00861 ENOG4105KT7 mgtC SapB transporter FX981_00862 ENOG4105G6Z alkaline phosphatase FX981_00863 ENOG4105CRN Aminoglycoside phosphotransferase FX981_00869 ENOG4105C1G acyl-Coa dehydrogenase FX981_00872 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FX981_00875 ENOG4105ED2 Beta-lactamase FX981_00879 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FX981_00880 ENOG4105C4R Atp-dependent dna helicase FX981_00881 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) FX981_00884 ENOG4105CBC glutamate synthase FX981_00885 ENOG4105KGF protein, YerC YecD FX981_00888 ENOG4107S4Y M20 DapE family protein YgeY FX981_00891 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FX981_00895 ENOG4105C12 Phosphoribosylglycinamide synthetase FX981_00896 ENOG4105DC1 bifunctional purine biosynthesis protein purh FX981_00897 ENOG4108V3E phosphoribosylglycinamide formyltransferase FX981_00898 ENOG4105CXB phosphoribosylaminoimidazole synthetase FX981_00900 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii FX981_00902 ENOG4105VR9 phosphoribosylformylglycinamidine synthase FX981_00903 ENOG4105C8V SAICAR synthetase FX981_00904 ENOG4105C83 adenylosuccinate lyase FX981_00905 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FX981_00906 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FX981_00908 ENOG4108U5N UPF0316 protein FX981_00912 ENOG4105C7N Xanthine uracil vitamin C permease FX981_00913 ENOG4105GZI Transcriptional regulator FX981_00914 ENOG4108RWP Major Facilitator Superfamily protein FX981_00916 ENOG4105JVQ RNA Polymerase FX981_00919 ENOG4105KNA -acetyltransferase FX981_00920 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_00926 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FX981_00928 ENOG4108UIN ybak prolyl-trna synthetase associated region FX981_00929 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) FX981_00932 ENOG4105C7R Atpase associated with various cellular activities aaa_3 FX981_00934 ENOG4105C85 amino acid FX981_00935 ENOG4107STQ Multicopper oxidase FX981_00945 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 FX981_00946 ENOG4108U05 Transcriptional regulator FX981_00948 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) FX981_00949 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) FX981_00950 ENOG4108TYN CAAX amino terminal protease family protein FX981_00953 ENOG4105DQ6 Transposase FX981_00955 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FX981_00956 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FX981_00957 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) FX981_00958 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) FX981_00959 ENOG4105C5H ABC transporter FX981_00960 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FX981_00961 ENOG410801F ribosomal-protein-alanine acetyltransferase FX981_00962 ENOG41072GX Peptidase M22 Glycoprotease FX981_00963 ENOG4105K8N protein family UPF0079, ATPase FX981_00964 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FX981_00975 ENOG4108UMN azlc family FX981_00981 ENOG4108JCI Transcriptional regulator FX981_00984 ENOG4108TVJ Nitroreductase FX981_00985 ENOG41090MY MarR family Transcriptional regulator FX981_00986 ENOG4105NAE bifunctional deaminase-reductase domain protein FX981_00987 ENOG4105ST3 Transcriptional regulator FX981_00989 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase FX981_00990 ENOG4105VDT -acetyltransferase FX981_00993 ENOG4105Z7P Acetyltransferase (GNAT) family FX981_00995 ENOG4108IG5 Transcriptional regulator FX981_00998 ENOG4107RB3 L-asparaginase FX981_01000 ENOG4105EMU Dehydrogenase FX981_01002 ENOG4105C0R drug resistance transporter emrb qaca subfamily FX981_01007 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FX981_01009 ENOG4105VUF Transcriptional regulator FX981_01010 ENOG4105DQ4 alcohol dehydrogenase FX981_01012 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_01013 ENOG4105VEQ Cold shock protein FX981_01014 ENOG4105RHY Pfam:UPF0157 FX981_01016 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FX981_01024 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FX981_01026 ENOG4107QKR Dehydrogenase FX981_01028 ENOG4107RUY (E1 component), alpha subunit FX981_01031 ENOG41064BQ Phosphatase FX981_01033 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FX981_01034 ENOG4105WN5 stage II sporulation protein FX981_01035 ENOG4107SGM protein serine threonine phosphatase FX981_01036 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase FX981_01037 ENOG4105FUA antagonist FX981_01038 ENOG4107MMM Anti-sigma-factor antagonist FX981_01039 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) FX981_01041 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FX981_01042 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein FX981_01045 ENOG4105CKV Membrane FX981_01046 ENOG410905X membrane-flanked domain protein FX981_01047 ENOG4105C1J atp-dependent rna helicase FX981_01050 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) FX981_01051 ENOG4105CPF Cell wall formation (By similarity) FX981_01052 ENOG4105SZ6 Thioredoxin FX981_01056 ENOG4105CJ1 ABC, transporter FX981_01058 ENOG4106F5Q Membrane FX981_01059 ENOG4107QJT sodium dicarboxylate symporter FX981_01060 ENOG4108MRH transcriptional regulatory protein FX981_01061 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FX981_01062 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FX981_01063 ENOG4105EU9 FX981_01064 ENOG4107BMA Transglycosylase associated protein FX981_01065 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) FX981_01073 ENOG4105C0X amino acid FX981_01075 ENOG4107R8N Glycosyl transferase, family 2 FX981_01076 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) FX981_01079 ENOG4105C9U ATP-dependent DNA helicase RecQ FX981_01080 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FX981_01081 ENOG410631K Membrane FX981_01082 ENOG4106AXJ AraC family transcriptional regulator FX981_01083 ENOG4105DRR Transcriptional regulator, GntR family FX981_01084 ENOG4105VCH membrane FX981_01089 ENOG410606W general stress protein FX981_01091 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FX981_01092 ENOG4105HMZ Methyltransferase FX981_01093 ENOG4105ETD TRANSCRIPTIONal FX981_01095 ENOG4105XJB lipolytic protein G-D-S-L family FX981_01096 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FX981_01097 ENOG4107258 Transcriptional regulator FX981_01099 ENOG4105P4J Allophanate hydrolase, subunit 1 FX981_01100 ENOG4105CFM UPF0317 protein FX981_01101 ENOG4105C5A transporter FX981_01102 ENOG4105E7W lamb ycsf family protein FX981_01104 ENOG4105X3H Excalibur domain protein FX981_01109 ENOG4105E1F short-chain dehydrogenase reductase FX981_01110 ENOG4105C8Q Methyl-accepting chemotaxis FX981_01111 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase FX981_01114 ENOG4108T5E Copper resistance protein FX981_01115 ENOG4105KTB nuclear export factor GLE1 FX981_01116 ENOG4105DYS nad(p)h dehydrogenase (quinone) FX981_01117 ENOG4105C26 Dehydrogenase FX981_01118 ENOG4107QTZ amino acid FX981_01119 ENOG4108JPW Aminotransferase FX981_01121 ENOG4105YVS arsR family transcriptional regulator FX981_01123 ENOG4105R8C Transcriptional regulator FX981_01125 ENOG4105CFH Aspartokinase FX981_01127 ENOG4105BZU Histidine kinase FX981_01128 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX981_01129 ENOG4108PGP mmge prpd family protein FX981_01130 ENOG4105CH2 amidohydrolase FX981_01132 ENOG4108HW4 amino acid AbC transporter FX981_01133 ENOG4105EAB amino acid AbC transporter FX981_01134 ENOG4108XSB acetyltransferase, (GNAT) family FX981_01135 ENOG4105CPU Monooxygenase FX981_01137 ENOG4105DUX Transporter FX981_01138 ENOG4105D2H Uronic isomerase FX981_01141 ENOG4107XBN GntR Family Transcriptional Regulator FX981_01142 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) FX981_01143 ENOG4105DMW Dehydrogenase reductase FX981_01144 ENOG4105CT4 transporter FX981_01145 ENOG4108IQI permease FX981_01147 ENOG4105DRP amino acid AbC transporter FX981_01148 ENOG4105CDA abc transporter atp-binding protein FX981_01153 ENOG4105SX7 Transporter FX981_01159 ENOG4105CEY Amp-dependent synthetase and ligase FX981_01161 ENOG4105F38 ABC transporter, permease FX981_01162 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FX981_01167 ENOG4105C8Q Methyl-accepting chemotaxis FX981_01169 ENOG4108AQF aminoglycoside N(3)-acetyltransferase FX981_01171 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein FX981_01173 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein FX981_01174 ENOG4105E5Q amino acid AbC transporter FX981_01175 ENOG4107R5R arsenical pump membrane protein FX981_01176 ENOG4107YHD transcriptional regulator FX981_01177 ENOG4105C26 Dehydrogenase FX981_01179 ENOG410756H nucleotidyltransferase FX981_01181 ENOG4105I82 acetyl xylan esterase FX981_01182 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FX981_01183 ENOG4105C5Q Transcriptional regulator FX981_01184 ENOG41089UC methyltransferase, type 11 FX981_01185 ENOG41079KZ Major Facilitator Superfamily FX981_01186 ENOG4105ETE Transcriptional regulator (LacI family FX981_01187 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FX981_01188 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) FX981_01189 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region FX981_01191 ENOG4105DJB Major Facilitator Superfamily FX981_01192 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FX981_01194 ENOG4105C7K acetolactate synthase FX981_01195 ENOG4105FF2 Type I DHQase FX981_01201 ENOG4107RMH nh(3)-dependent nad( ) synthetase FX981_01202 ENOG4105EIG urea carboxylase-associated protein 1 FX981_01209 ENOG4105TRI Hydrolase FX981_01213 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FX981_01219 ENOG4107SQ8 Glycine betaine FX981_01220 ENOG4108IJ7 Glycine betaine FX981_01222 ENOG4108TTB tellurium resistance protein FX981_01227 ENOG4107TS3 membrane protein, TerC FX981_01228 ENOG4106FN3 tellurium resistance protein FX981_01229 ENOG4106FN3 tellurium resistance protein FX981_01230 ENOG4108N0M stress protein FX981_01231 ENOG4105DEN Luciferase family FX981_01233 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FX981_01237 ENOG4108SDH ABC, transporter FX981_01238 ENOG4108IUW ABC transporter FX981_01239 ENOG4107Y7X LytTR FX981_01241 ENOG4107SET aldo keto reductase FX981_01243 ENOG4105BZU Histidine kinase FX981_01244 ENOG4105WH1 Two component transcriptional regulator luxr family FX981_01246 ENOG41060AI SEC-C motif FX981_01249 ENOG4105CSV Glutaminase FX981_01251 ENOG4105D74 hydrolase FX981_01253 ENOG4105CUB amino acid FX981_01255 ENOG41067TZ transcriptional regulator, MarR family FX981_01256 ENOG4105E2A Dehydrogenase FX981_01258 ENOG4105J7D transcriptional regulator FX981_01260 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_01264 ENOG4105C2C drug resistance transporter, Bcr CflA FX981_01268 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) FX981_01269 ENOG4108J5H Homocysteine s-methyltransferase FX981_01270 ENOG4108IQI permease FX981_01273 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_01274 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FX981_01275 ENOG4108YRF PTS System FX981_01276 ENOG4105DM4 PTS System FX981_01277 ENOG4105C8I hydrolase, family 38 FX981_01278 ENOG4105EVU fructokinase FX981_01279 ENOG4105EMD TRANSCRIPTIONal FX981_01283 ENOG4105CS2 ec 3.2.1.21 FX981_01284 ENOG4105C5Y PTS System FX981_01285 ENOG4105CID antiterminator FX981_01286 ENOG4107QTZ amino acid FX981_01287 ENOG4105C72 UPF0176 protein FX981_01288 ENOG4107SCQ Iron-containing alcohol dehydrogenase FX981_01291 ENOG4105EWC Purine nucleoside phosphorylase FX981_01295 ENOG4108SUT Major Facilitator Superfamily FX981_01296 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) FX981_01298 ENOG41087NI Sulfite exporter TauE/SafE FX981_01299 ENOG4105VFE sira family FX981_01300 ENOG4107TPS domain protein FX981_01301 ENOG4105VFE sira family FX981_01303 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase FX981_01304 ENOG4105XTG Pfam:DUF156 FX981_01308 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FX981_01309 ENOG4105C7Z Conserved Protein FX981_01311 ENOG4105CXY transporter FX981_01312 ENOG4107VXM glycerophosphoryl diester phosphodiesterase FX981_01314 ENOG4105DQ6 Transposase FX981_01324 ENOG4108WUZ (ABC) transporter FX981_01327 ENOG4105DA5 (ABC) transporter FX981_01330 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FX981_01331 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FX981_01332 ENOG4107U5W ybbr family FX981_01333 ENOG4105C8B TIGR00159 family FX981_01335 ENOG4105EMN RNA polymerase sigma factor FX981_01342 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate FX981_01346 ENOG4105D17 glycoside hydrolase, family 3 domain protein FX981_01347 ENOG4105EHZ conserved protein UCP016719 FX981_01349 ENOG4105CHH sulfate transporter FX981_01355 ENOG4108NMV polysaccharide deacetylase FX981_01358 ENOG4105D1F ATP-binding protein FX981_01365 ENOG4108UJD 30S ribosomal protein S9 FX981_01366 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) FX981_01367 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) FX981_01368 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FX981_01369 ENOG4108JJB ABC transporter FX981_01370 ENOG4108JJB ABC transporter FX981_01371 ENOG4108ZT0 50S ribosomal protein l17 FX981_01372 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FX981_01373 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) FX981_01374 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FX981_01376 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FX981_01377 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FX981_01378 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) FX981_01379 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FX981_01380 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) FX981_01381 ENOG4105VPB 50S ribosomal protein L30 FX981_01382 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FX981_01383 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FX981_01384 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) FX981_01385 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FX981_01386 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FX981_01387 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits FX981_01388 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FX981_01389 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) FX981_01390 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FX981_01391 ENOG41082SA 50s ribosomal protein l29 FX981_01392 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FX981_01393 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FX981_01394 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FX981_01395 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FX981_01396 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity FX981_01397 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FX981_01398 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FX981_01399 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) FX981_01400 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) FX981_01401 ENOG4107SKW Inherit from COG: Alpha beta hydrolase FX981_01403 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) FX981_01404 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) FX981_01405 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) FX981_01406 ENOG4105XPM ribosomal protein FX981_01407 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FX981_01408 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FX981_01409 ENOG4107Y49 methyltransferase FX981_01410 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) FX981_01411 ENOG4108VZM 50s ribosomal protein L10 FX981_01412 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) FX981_01413 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) FX981_01414 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FX981_01417 ENOG4105M0M Tetracycline resistance protein FX981_01418 ENOG4105C2N RNA methyltransferase TrmH family group 3 FX981_01419 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) FX981_01420 ENOG4105C8N cysteinyl-tRNA synthetase FX981_01421 ENOG4105D7W serine acetyltransferase FX981_01422 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) FX981_01423 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) FX981_01424 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) FX981_01425 ENOG4105CTP PilT protein domain protein FX981_01426 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) FX981_01427 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FX981_01429 ENOG41066A3 ATP guanido phosphotransferase FX981_01430 ENOG4108Z0C Uvrb UvrC protein FX981_01447 ENOG4105CRK lysyL-tRNA synthetase FX981_01448 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FX981_01450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FX981_01451 ENOG4105KRF dihydroneopterin aldolase FX981_01452 ENOG4105EEI dihydropteroate synthase FX981_01453 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 FX981_01454 ENOG4105DDQ anthranilate synthase FX981_01455 ENOG4105CRQ synthase (Component I) FX981_01456 ENOG4105C6T cysteine synthase FX981_01457 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase FX981_01458 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) FX981_01459 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) FX981_01460 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FX981_01461 ENOG4108UGV hypoxanthine phosphoribosyltransferase FX981_01462 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FX981_01468 ENOG41060GV RNA binding s1 domain protein FX981_01471 ENOG4105VYY sporulation protein yabp FX981_01472 ENOG41082I2 s4 domain protein FX981_01473 ENOG4108IY2 MazG family FX981_01475 ENOG4108M14 stage v sporulation protein t FX981_01476 ENOG4108JA2 transcriptioN-repair coupling factor FX981_01478 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) FX981_01479 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) FX981_01480 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FX981_01481 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FX981_01483 ENOG4105KME endoribonuclease L-psp FX981_01484 ENOG4105DFT pur operon repressor FX981_01485 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FX981_01486 ENOG4105XEW small acid-soluble spore protein FX981_01487 ENOG4105W42 Veg protein FX981_01488 ENOG4105XFA sporulation peptidase YabG FX981_01489 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) FX981_01491 ENOG41069ER domain protein FX981_01492 ENOG4105F8V Hydrolase, tatD family FX981_01493 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) FX981_01494 ENOG4105KRN Transcriptional regulator, abrb family FX981_01495 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FX981_01496 ENOG4105VC4 domain protein FX981_01497 ENOG41060K3 Methyltransferase FX981_01498 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) FX981_01499 ENOG4105MA4 psp1 domain protein FX981_01500 ENOG4105FA2 dna polymerase iii FX981_01501 ENOG4105XVJ Protein of unknown function (DUF327) FX981_01502 ENOG4105X0R protein from nitrogen regulatory protein P-II FX981_01503 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) FX981_01504 ENOG4105CXN decarboxylase FX981_01505 ENOG4105CDW Resistance protein FX981_01513 ENOG41067KS pro-sigma K processing FX981_01515 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) FX981_01516 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) FX981_01517 ENOG4105C6E dna polymerase iii FX981_01518 ENOG4108Z6B deaminase FX981_01519 ENOG4105GTG Isochorismatase FX981_01520 ENOG4105VRS hydrolase family 18 FX981_01522 ENOG4105ZMH deoxynucleoside kinase FX981_01524 ENOG4105FKZ Methyl-accepting chemotaxis FX981_01525 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) FX981_01526 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) FX981_01527 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) FX981_01528 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FX981_01530 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FX981_01537 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX981_01538 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX981_01540 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FX981_01541 ENOG410848D S4 domain protein YaaA FX981_01542 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FX981_01543 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) FX981_01544 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) FX981_01545 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins FX981_01547 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) FX981_01548 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) FX981_01549 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) FX981_01551 ENOG4107QJE Chromosome Partitioning Protein FX981_01552 ENOG4105FA0 parb-like partition protein FX981_01553 ENOG4108ZDA Sporulation protein YyaC FX981_01557 ENOG4105VDK protein, conserved in bacteria FX981_01558 ENOG4105C3G gtp-binding protein FX981_01559 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) FX981_01560 ENOG4108UUM single-stranded DNA-binding protein FX981_01561 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FX981_01562 ENOG4108IJ8 ABC transporter FX981_01563 ENOG4105E90 ABC transporter FX981_01564 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase FX981_01565 ENOG4105FBA Phospholipase Carboxylesterase FX981_01566 ENOG4105CS1 NAD(P)H quinone oxidoreductase FX981_01567 ENOG4105CH6 catalase FX981_01569 ENOG4105JVQ RNA Polymerase FX981_01570 ENOG4108P49 AntiSigma factor FX981_01571 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase FX981_01572 ENOG4108XMW Membrane FX981_01573 ENOG4105BZR domain protein FX981_01574 ENOG4105K9Q Binds to the 23S rRNA (By similarity) FX981_01575 ENOG4105DJ2 Major Facilitator Superfamily FX981_01577 ENOG4108SA1 esterase FX981_01579 ENOG410874W AraC family transcriptional regulator FX981_01580 ENOG4105WQT MbtH domain protein FX981_01581 ENOG4105CEY Amp-dependent synthetase and ligase FX981_01582 ENOG4105WQI isochorismatase FX981_01583 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FX981_01584 ENOG4105E4F Isochorismate synthase FX981_01585 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FX981_01586 ENOG4105NIV Esterase FX981_01589 ENOG4106K80 FX981_01590 ENOG4105CDU Replicative dna helicase FX981_01591 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase FX981_01592 ENOG4106A3M Cytochrome p-450 FX981_01594 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis FX981_01597 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FX981_01602 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX981_01603 ENOG4105BZU Histidine kinase FX981_01606 ENOG4105Q2H domain protein FX981_01607 ENOG4105C0H protease FX981_01608 ENOG4105WQG acetyltransferase FX981_01612 ENOG4108V7D UPF0397 protein FX981_01614 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) FX981_01616 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) FX981_01624 ENOG4107Y5K Resolvase FX981_01627 ENOG4108JQA flagellar FX981_01632 ENOG4105WAB arsR family transcriptional regulator FX981_01633 ENOG4108RWP Major Facilitator Superfamily protein FX981_01635 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FX981_01639 ENOG41080UQ Transcriptional regulator FX981_01640 ENOG4105JAB phenazine biosynthesis protein, phzf family FX981_01642 ENOG4108S3Y transcriptional regulator FX981_01644 ENOG4105CS2 ec 3.2.1.21 FX981_01649 ENOG4105E2X shikimate dehydrogenase FX981_01652 ENOG4105ETE Transcriptional regulator (LacI family FX981_01653 ENOG4105C85 amino acid FX981_01660 ENOG410780I phosphoprotein phosphatase activity FX981_01662 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FX981_01664 ENOG4107Y80 Major Facilitator superfamily FX981_01665 ENOG4105YA8 Transcriptional regulator FX981_01666 ENOG4107VHA regulatoR FX981_01667 ENOG4107QQ0 gntp family FX981_01668 ENOG4105BZW Glycerate kinase FX981_01669 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FX981_01670 ENOG4105CJ1 ABC, transporter FX981_01671 ENOG4108TU7 Inherit from COG: (ABC) transporter FX981_01673 ENOG4105D4T Citrate transporter FX981_01676 ENOG4105EG2 ABC transporter, permease FX981_01678 ENOG4107FKK extracellular solute-binding protein family 1 FX981_01680 ENOG4105DUM transcriptional regulator, lysR family FX981_01684 ENOG4106KNT transcriptional regulator FX981_01685 ENOG4105CMG Carbohydrate kinase FX981_01686 ENOG4105C6Z Gluconate FX981_01687 ENOG4105F1N DNA alkylation repair FX981_01689 ENOG4105FKZ Methyl-accepting chemotaxis FX981_01690 ENOG4105EE0 oxidoreductase FX981_01691 ENOG4105W1Y Transcriptional regulator FX981_01692 ENOG410667J hydrolase FX981_01696 ENOG4105EXC Acyl-transferase FX981_01698 ENOG4107RHR regulatoR FX981_01699 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) FX981_01700 ENOG4105D9N nucleoside FX981_01701 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) FX981_01702 ENOG4105FS7 Transcriptional regulator FX981_01703 ENOG4108TVJ Nitroreductase FX981_01704 ENOG41067V3 Antibiotic biosynthesis monooxygenase FX981_01705 ENOG4107G87 m6 family metalloprotease domain protein FX981_01711 ENOG4105ETU transcriptional activator (TenA FX981_01712 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein FX981_01713 ENOG4108JJB ABC transporter FX981_01714 ENOG4108W7F transporter, permease FX981_01716 ENOG4108XI2 Domain of unknown function (DUF1963) FX981_01717 ENOG4105CID antiterminator FX981_01718 ENOG4105C5Y PTS System FX981_01719 ENOG4105CS2 ec 3.2.1.21 FX981_01722 ENOG4105C6Z Gluconate FX981_01724 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FX981_01725 ENOG4106KNT transcriptional regulator FX981_01728 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FX981_01734 ENOG4108IMY Transcriptional regulator FX981_01735 ENOG4105HDK L-asparaginase FX981_01736 ENOG4108IJ0 Aspartate ammonia-lyase FX981_01737 ENOG4105DFD Na H antiporter FX981_01742 ENOG4105EMD TRANSCRIPTIONal FX981_01743 ENOG4105CK1 PTS System FX981_01744 ENOG4105CS2 ec 3.2.1.21 FX981_01745 ENOG4105VZJ PTS System FX981_01746 ENOG4105VCP PTS System FX981_01747 ENOG4107BJW polysaccharide deacetylase FX981_01749 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FX981_01750 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FX981_01751 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase FX981_01752 ENOG4105KVH Transcriptional regulator FX981_01753 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) FX981_01754 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) FX981_01759 ENOG4105KFN sortase, SrtB family FX981_01761 ENOG4105S6R Iron-hydroxamate transporter permease subunit FX981_01763 ENOG4105C4M (Ubiquinol oxidase) subunit I FX981_01764 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FX981_01765 ENOG4108JJ9 ABC, transporter FX981_01766 ENOG4108JJ8 (ABC) transporter FX981_01767 ENOG4108J20 pectate lyase FX981_01771 ENOG4107R37 Glutamate dehydrogenase FX981_01775 ENOG4105EMD TRANSCRIPTIONal FX981_01776 ENOG4105VZJ PTS System FX981_01777 ENOG4105CK1 PTS System FX981_01778 ENOG4105VCP PTS System FX981_01779 ENOG4105F8D glycoside hydrolase family 4 FX981_01782 ENOG4105CM2 brancheD-chain amino acid aminotransferase FX981_01783 ENOG4108M26 parallel beta-helix repeat protein FX981_01784 ENOG4108QGH periplasmic FX981_01785 ENOG4105C2J ABC transporter FX981_01786 ENOG4105CNN ABC, transporter FX981_01790 ENOG4107R0W ABC transporter FX981_01791 ENOG4105E5Q amino acid AbC transporter FX981_01794 ENOG4105DR4 Methyltransferase FX981_01795 ENOG41067MG lrgb family FX981_01797 ENOG4105CMU LysR family (Transcriptional regulator FX981_01798 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FX981_01799 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) FX981_01808 ENOG4105WH5 Teichoic acid glycosylation protein FX981_01811 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) FX981_01812 ENOG4105CMR udp-glucose 4-epimerase FX981_01815 ENOG4105E2S oxidase) subunit II FX981_01816 ENOG4105BZ9 Cytochrome C oxidase, subunit I FX981_01817 ENOG4105CCU oxidase (Subunit III) FX981_01818 ENOG41060D1 Quinol oxidase FX981_01821 ENOG4108DBC nitroreductase FX981_01822 ENOG4105DEN Luciferase family FX981_01823 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_01826 ENOG4105C5Y PTS System FX981_01829 ENOG41069H0 dihydroorotase EC 3.5.2.3 FX981_01833 ENOG4105DWF phosphomethylpyrimidine kinase FX981_01835 ENOG4108RJ9 Glycosyl transferase, family 2 FX981_01836 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) FX981_01837 ENOG4105C26 Dehydrogenase FX981_01847 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FX981_01848 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD FX981_01850 ENOG4107TY6 Acylneuraminate cytidylyltransferase FX981_01851 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG FX981_01852 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FX981_01853 ENOG4105C1B dTDP-glucose 4-6-dehydratase FX981_01854 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FX981_01855 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase FX981_01857 ENOG4105CHM Aminotransferase FX981_01858 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase FX981_01859 ENOG4105CHR reductase FX981_01861 ENOG41061WN bacilysin biosynthesis protein FX981_01862 ENOG4105FCW Major Facilitator superfamily FX981_01864 ENOG4105F27 Major Facilitator FX981_01865 ENOG4107JTW chlorite dismutase FX981_01866 ENOG4108IJ2 phosphate acetyltransferase FX981_01869 ENOG4105JSC dimethylmenaquinone methyltransferase FX981_01881 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) FX981_01884 ENOG4107QZ7 Cellulose synthase catalytic subunit FX981_01886 ENOG4108VCI transcription factor, rsfa family FX981_01887 ENOG4105QAT UPF0741 protein FX981_01888 ENOG4105DCI Phosphohydrolase FX981_01890 ENOG4105CDA abc transporter atp-binding protein FX981_01891 ENOG4105E5Q amino acid AbC transporter FX981_01894 ENOG4108XSB acetyltransferase, (GNAT) family FX981_01896 ENOG4105DEN Luciferase family FX981_01897 ENOG4108UZX fmn reductase FX981_01898 ENOG4108KSA LysR family transcriptional regulator FX981_01901 ENOG41069HH 4-oxalocrotonate tautomerase FX981_01902 ENOG4108Z4T Peptidase M50 FX981_01903 ENOG4108XFG YwhD family FX981_01904 ENOG4105BZ4 penicillin-binding protein FX981_01905 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) FX981_01906 ENOG4105CYW agmatinase FX981_01908 ENOG410684U Domain of unknown function (DUF1934) FX981_01909 ENOG4105C75 arginyL-tRNA synthetase FX981_01911 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) FX981_01912 ENOG4105BZ1 (ABC) transporter FX981_01913 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FX981_01917 ENOG4105DF6 Fe-S oxidoreductase FX981_01919 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FX981_01920 ENOG4105C1G acyl-Coa dehydrogenase FX981_01921 ENOG4105C1G acyl-Coa dehydrogenase FX981_01930 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) FX981_01932 ENOG410812K response regulator receiver protein FX981_01933 ENOG4105D2N Aldolase FX981_01935 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FX981_01936 ENOG4105CBT Fructose-1,6-bisphosphatase FX981_01937 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) FX981_01938 ENOG41082DI 50s ribosomal protein l31 FX981_01939 ENOG4107104 thymidine kinase FX981_01940 ENOG4105C6K Malic enzyme FX981_01941 ENOG4107TT2 Auxin Efflux Carrier FX981_01943 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) FX981_01944 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FX981_01946 ENOG4108ZXQ stage ii sporulation protein r FX981_01948 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FX981_01950 ENOG4107WAU Protein tyrosine phosphatase FX981_01951 ENOG4108YZG isomerase FX981_01952 ENOG4108UIC UPF0340 protein FX981_01953 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) FX981_01954 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) FX981_01956 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) FX981_01960 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) FX981_01961 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) FX981_01962 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) FX981_01963 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) FX981_01965 ENOG4106778 Protein of unknown function (DUF1146) FX981_01967 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) FX981_01970 ENOG4108TF4 von Willebrand factor, type A FX981_01971 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FX981_01972 ENOG4105FCD Major Facilitator FX981_01973 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) FX981_01975 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) FX981_01976 ENOG4105CKI cobalamin synthesis protein FX981_01977 ENOG410861F 50S ribosomal protein L33 FX981_01985 ENOG4107TCE N-acetyltransferase FX981_01986 ENOG4105FRN stage II sporulation protein FX981_01988 ENOG4105BZU Histidine kinase FX981_01990 ENOG4105E5Q amino acid AbC transporter FX981_01991 ENOG4105EAB amino acid AbC transporter FX981_01992 ENOG41080V3 Major Facilitator superfamily FX981_01993 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FX981_01994 ENOG4105CZM Major Facilitator FX981_01995 ENOG4107MII Sugar-specific transcriptional regulator TrmB FX981_01996 ENOG4105MT0 Sporulation transcriptional regulator spoiiid FX981_01997 ENOG4105DFF Rod shape-determining protein mreb FX981_01999 ENOG4105CGA flagellar basal-body rod protein FlgG FX981_02001 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) FX981_02002 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) FX981_02005 ENOG410667J hydrolase FX981_02006 ENOG4105BZU Histidine kinase FX981_02007 ENOG4105C0D helicase FX981_02008 ENOG4105KBK Zinc finger, swim domain protein FX981_02010 ENOG4105C6Y Udp-glucose 6-dehydrogenase FX981_02011 ENOG4105FGV Chromate FX981_02012 ENOG4105CAH Chromate FX981_02014 ENOG4107FQX Alpha-acetolactate decarboxylase FX981_02016 ENOG4107RSM transcriptional regulator FX981_02017 ENOG4107XC4 flavin reductase domain protein, FMN-binding FX981_02018 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FX981_02019 ENOG4105CNN ABC, transporter FX981_02020 ENOG4105C2J ABC transporter FX981_02021 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FX981_02022 ENOG4108RVA ribokinase FX981_02023 ENOG4105ETE Transcriptional regulator (LacI family FX981_02027 ENOG4105N98 Capsule biosynthesis protein capB FX981_02029 ENOG4105PNM synthesis protein FX981_02031 ENOG4105K4H Nlp p60 protein FX981_02032 ENOG4105J7I hydrolase FX981_02033 ENOG4108KGH TRANSCRIPTIONal FX981_02034 ENOG4105C54 Major Facilitator superfamily FX981_02035 ENOG4107QJZ Glycosyl transferase, family 2 FX981_02036 ENOG4108NHD germination protein FX981_02039 ENOG4105CHR reductase FX981_02040 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) FX981_02041 ENOG4108M60 Transcriptional regulator FX981_02042 ENOG4105D7K pfkb domain protein FX981_02043 ENOG4108UHU Aldolase FX981_02044 ENOG4105I4A GCN5-related N-acetyltransferase FX981_02046 ENOG4105C2F Histidine kinase FX981_02047 ENOG4107YTP response regulator receiver protein FX981_02048 ENOG4108JP0 extracellular solute-binding protein family 1 FX981_02049 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component FX981_02051 ENOG4105DG6 mannose-6-phosphate isomerase FX981_02053 ENOG4107RZX Teichoic acid biosynthesis protein FX981_02055 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase FX981_02057 ENOG4107SJB teichoic acid biosynthesis FX981_02060 ENOG4105EY8 ABC transporter FX981_02061 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FX981_02062 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FX981_02065 ENOG4105JFG SpoIID LytB domain protein FX981_02066 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FX981_02067 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FX981_02069 ENOG4105D3Q Sugar transferase FX981_02070 ENOG4105PSV Polysaccharide Biosynthesis Protein FX981_02071 ENOG4107RA4 Glycosyl transferase (Group 1 FX981_02072 ENOG4105C6Y Udp-glucose 6-dehydrogenase FX981_02073 ENOG4105C1B dTDP-glucose 4-6-dehydratase FX981_02074 ENOG4105QZI O-Antigen Polymerase FX981_02077 ENOG4107EF8 Glycosyl transferase (Group 1 FX981_02078 ENOG4105ESV Glycosyl transferase, family 4 FX981_02079 ENOG4108KGH TRANSCRIPTIONal FX981_02080 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FX981_02081 ENOG4105BZU Histidine kinase FX981_02082 ENOG4105WH1 Two component transcriptional regulator luxr family FX981_02086 ENOG41081UC Inherit from COG: Competence protein FX981_02087 ENOG4105RU3 FX981_02090 ENOG4105E1Q flagellar hook-associated protein FX981_02091 ENOG4105DTJ flagellar hook-associated protein FX981_02092 ENOG4105MKD FX981_02093 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) FX981_02094 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FX981_02095 ENOG41083S7 flagellar protein FlaG FX981_02096 ENOG4107RT6 flagellar hook-associated FX981_02097 ENOG4105MQ3 flagellar protein FliS FX981_02100 ENOG4105C8Q Methyl-accepting chemotaxis FX981_02101 ENOG4105MS2 ribosomal subunit Interface protein FX981_02103 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) FX981_02108 ENOG4105CAK Cell division ATP-binding protein ftsE FX981_02109 ENOG4105CRP Part of the ABC transporter FtsEX involved in FX981_02112 ENOG4105CN1 protease FX981_02115 ENOG4105KVH Transcriptional regulator FX981_02116 ENOG4108RCM Nitroreductase FX981_02118 ENOG4105CKK Glycosyl transferase, family 2 FX981_02119 ENOG4105EDW glycosyl transferase, family 39 FX981_02120 ENOG4105BZU Histidine kinase FX981_02121 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX981_02124 ENOG4105MKU Transcriptional regulator FX981_02127 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) FX981_02128 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FX981_02131 ENOG4108PY7 FX981_02132 ENOG41067S9 phage shock protein C, PspC FX981_02133 ENOG41086DT Membrane protein of unknown function FX981_02134 ENOG41088CQ domain protein FX981_02135 ENOG4105FDP GntR family transcriptional regulator FX981_02136 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) FX981_02137 ENOG4105CE4 GlcNAc 6-P deacetylase FX981_02138 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) FX981_02140 ENOG4105HKU nucleoside recognition domain-containing protein FX981_02141 ENOG4107XGZ Hydrolase FX981_02142 ENOG4108S4C acetyltransferase FX981_02143 ENOG4108Z40 Transcriptional regulator FX981_02144 ENOG4108RYK Nad-dependent epimerase dehydratase FX981_02147 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) FX981_02148 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) FX981_02149 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FX981_02150 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FX981_02151 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FX981_02152 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase FX981_02153 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) FX981_02154 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FX981_02157 ENOG4105C3M thioredoxin reductase FX981_02158 ENOG4108Z4K mutator MutT protein FX981_02159 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) FX981_02160 ENOG4105CHW UPF0052 protein FX981_02161 ENOG4105CIE May be required for sporulation (By similarity) FX981_02162 ENOG4105KRI phosphocarrier protein (HPr FX981_02163 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FX981_02165 ENOG4105C5I Dehydrogenase FX981_02166 ENOG4108V2W Carbonate dehydratase FX981_02167 ENOG4105CHH sulfate transporter FX981_02168 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain FX981_02169 ENOG4108URH decarboxylase FX981_02170 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) FX981_02175 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) FX981_02180 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FX981_02181 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX981_02186 ENOG4108ZJ4 polysaccharide deacetylase FX981_02187 ENOG4105DQ5 transport system permease protein FX981_02188 ENOG4105EHG Permease protein FX981_02189 ENOG4108V5C ABC transporter FX981_02192 ENOG4105HTX biosynthesis protein FX981_02193 ENOG4108QV3 biosynthesis protein FX981_02195 ENOG4108PQP glycosyl transferase group 1 FX981_02196 ENOG4105K64 Glycosyl transferase, family 2 FX981_02197 ENOG4108KMV Glycosyl transferase (Group 1 FX981_02198 ENOG41068W6 Capsular polysaccharide biosynthesis protein FX981_02199 ENOG4107QRS glycosyltransferase group 2 family protein FX981_02202 ENOG4105D3Q Sugar transferase FX981_02203 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family FX981_02204 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FX981_02205 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FX981_02206 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX981_02207 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX981_02208 ENOG4105C3U ABC transporter FX981_02210 ENOG4107R73 Mate efflux family protein FX981_02212 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX981_02213 ENOG4105JXH GntR family transcriptional regulator FX981_02214 ENOG4108JUB Transcriptional regulator FX981_02215 ENOG4105C8Y Acetylornithine aminotransferase FX981_02219 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FX981_02220 ENOG4105BZA Phosphoglycerate kinase FX981_02221 ENOG4105CP7 Triose-phosphate isomerase FX981_02223 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) FX981_02225 ENOG4108JJB ABC transporter FX981_02229 ENOG4108W0I acetyltransferase FX981_02231 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FX981_02232 ENOG4107HG4 Transcriptional regulator FX981_02233 ENOG4108IJ8 ABC transporter FX981_02234 ENOG4105E90 ABC transporter FX981_02235 ENOG4108HQR Glycine betaine FX981_02236 ENOG4105R40 Glycine betaine carnitine choline FX981_02237 ENOG4105KVH Transcriptional regulator FX981_02242 ENOG4105XZU Preprotein translocase, subunit SecG FX981_02244 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FX981_02245 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) FX981_02255 ENOG4105BZU Histidine kinase FX981_02257 ENOG4105VPX protein, conserved in bacteria FX981_02258 ENOG410681U heavy metal transport detoxification protein FX981_02259 ENOG4105C59 p-type ATPase FX981_02262 ENOG4108IJ0 Aspartate ammonia-lyase FX981_02265 ENOG4105W1N transcriptional regulator FX981_02266 ENOG4105IIP Membrane FX981_02267 ENOG4105DSE periplasmic solute binding protein FX981_02268 ENOG4105CC5 ABC transporter FX981_02269 ENOG4105DIK (ABC) transporter FX981_02270 ENOG4105C59 p-type ATPase FX981_02271 ENOG4107ZQN disulfide bond FX981_02273 ENOG4105EN6 Membrane FX981_02274 ENOG4107SUZ Sodium/hydrogen exchanger family FX981_02275 ENOG4105EVU fructokinase FX981_02277 ENOG4105E0C molybdate abc transporter FX981_02278 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FX981_02279 ENOG4107QZ2 Sulfatase FX981_02280 ENOG4107K5X Membrane-bound metal-dependent hydrolase FX981_02283 ENOG4105D5Q Arginine ornithine antiporter FX981_02285 ENOG4105DQ5 transport system permease protein FX981_02286 ENOG4105EHG Permease protein FX981_02287 ENOG4105E0A ABC, transporter FX981_02288 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FX981_02290 ENOG4105D2H Uronic isomerase FX981_02291 ENOG4107KJX Transcriptional regulator FX981_02292 ENOG4107QZW Altronate oxidoreductase FX981_02293 ENOG4105CTX dehydratase FX981_02295 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FX981_02296 ENOG4105EHG Permease protein FX981_02297 ENOG4105E0A ABC, transporter FX981_02299 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FX981_02300 ENOG4105C0A alcohol dehydrogenase FX981_02303 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FX981_02304 ENOG4107S2N Type III effector Hrp-dependent FX981_02305 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) FX981_02306 ENOG4105CHR reductase FX981_02307 ENOG4108WBT adenosyltransferase FX981_02309 ENOG41087YS Phage shock protein A FX981_02312 ENOG4105ENE Histidine kinase FX981_02313 ENOG4105WH1 Two component transcriptional regulator luxr family FX981_02319 ENOG4105C9Q fumarate hydratase class II FX981_02321 ENOG41067SE Tetr family transcriptional regulator FX981_02323 ENOG4105F3H Histidine kinase FX981_02325 ENOG4105C0H protease FX981_02326 ENOG4105E1F short-chain dehydrogenase reductase FX981_02328 ENOG4105E0A ABC, transporter FX981_02334 ENOG4105CHU acetyl-coa acetyltransferase FX981_02335 ENOG4105C1G acyl-Coa dehydrogenase FX981_02336 ENOG41080E8 Transcriptional regulator, Spx MgsR family FX981_02337 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) FX981_02342 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FX981_02343 ENOG4108UMI ABC transporter, permease FX981_02344 ENOG4105D01 (LipO)protein FX981_02346 ENOG4105C3K feS assembly ATPase SufC FX981_02347 ENOG4105JRK feS assembly protein SufD FX981_02348 ENOG4105C9B Cysteine desulfurase FX981_02349 ENOG4108UNV SUF system FeS assembly protein, NifU family FX981_02350 ENOG4105DIW FeS assembly protein SUFB FX981_02351 ENOG4108IG5 Transcriptional regulator FX981_02353 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) FX981_02355 ENOG4105DHF Membrane FX981_02356 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FX981_02357 ENOG4108SWU Histidine kinase FX981_02359 ENOG4108HCJ Hydrolase FX981_02362 ENOG4108MES Periplasmic binding protein FX981_02363 ENOG4105DQ5 transport system permease protein FX981_02364 ENOG4108IHU transport system permease protein FX981_02366 ENOG4108K8S endonuclease I FX981_02367 ENOG4105C5R Aminotransferase FX981_02369 ENOG4105F0F Oxalate decarboxylase FX981_02370 ENOG4105G9B Transcriptional regulator FX981_02371 ENOG4105I3N Conserved Protein FX981_02372 ENOG4107R8B 5'-nucleotidase FX981_02373 ENOG4105KZD Domain of unknown function (DUF1805) FX981_02374 ENOG4108YTE sporulation protein YunB FX981_02375 ENOG4105FAA peptidase M23 FX981_02377 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) FX981_02378 ENOG4105MMD transcriptional regulator FX981_02380 ENOG4105D4U had-superfamily hydrolase, subfamily iia FX981_02381 ENOG4108W5N phosphatidylglycerophosphatase a FX981_02383 ENOG4105C5I Dehydrogenase FX981_02384 ENOG4105D6E homoserine dehydrogenase FX981_02385 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) FX981_02387 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein FX981_02388 ENOG41083MR nifu domain-containing protein FX981_02392 ENOG4105ZKE UPF0349 protein FX981_02393 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) FX981_02394 ENOG4108YX9 iron--sulfur cluster insertion protein erpA FX981_02395 ENOG4107TXC Transcriptional regulator FX981_02397 ENOG4105CAY ferredoxin--nadp reductase FX981_02398 ENOG4105CEP NADH dehydrogenase FX981_02401 ENOG41069ER domain protein FX981_02403 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) FX981_02405 ENOG4108N23 SpoOM-related protein FX981_02407 ENOG4105DCF alanine dehydrogenase FX981_02408 ENOG4108K8K Transcriptional regulator FX981_02415 ENOG410904N short-chain dehydrogenase reductase FX981_02419 ENOG4105C02 permease FX981_02425 ENOG4105DAP Nicotinate phosphoribosyltransferase FX981_02426 ENOG4105D58 Diguanylate phosphodiesterase FX981_02431 ENOG4105BZU Histidine kinase FX981_02433 ENOG4105KA0 thioesterase Superfamily protein FX981_02434 ENOG4105KJM monovalent cation h antiporter subunit g FX981_02436 ENOG4105SC1 monovalent cation H antiporter subunit E FX981_02437 ENOG4108JPZ Monovalent cation H antiporter subunit D FX981_02438 ENOG4108ZE9 Monovalent cation H antiporter subunit C FX981_02439 ENOG4105HC0 Na H antiporter FX981_02440 ENOG4105D65 subunit l FX981_02444 ENOG4105UIB (ABC) transporter FX981_02445 ENOG4108JQ9 ABC transporter FX981_02446 ENOG4105DIH basic membrane FX981_02447 ENOG4108MRH transcriptional regulatory protein FX981_02450 ENOG4105KIR Thiol-disulfide oxidoreductase dcc FX981_02451 ENOG4105BZ4 penicillin-binding protein FX981_02454 ENOG4105Y38 Kinase-associated protein B FX981_02456 ENOG4108HGU Histidine kinase FX981_02457 ENOG4105C87 Aminotransferase class I and II FX981_02458 ENOG4108MUZ hydrolase FX981_02459 ENOG4108ZB6 transcriptional regulator AsnC family FX981_02460 ENOG4105CHM Aminotransferase FX981_02462 ENOG4105WG9 Conserved Protein FX981_02463 ENOG4107QW4 alcohol dehydrogenase FX981_02465 ENOG4107QYV phosphohexose isomerase FX981_02468 ENOG4107PBV potassium channel FX981_02471 ENOG4105C37 (CBS) domain FX981_02472 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FX981_02473 ENOG4105EA8 2-Nitropropane dioxygenase FX981_02476 ENOG4105C8Q Methyl-accepting chemotaxis FX981_02477 ENOG4105C8Q Methyl-accepting chemotaxis FX981_02478 ENOG4105C8Q Methyl-accepting chemotaxis FX981_02479 ENOG4105C8Q Methyl-accepting chemotaxis FX981_02480 ENOG4108Z0Z intracellular protease Pfpi family FX981_02481 ENOG4105EE0 oxidoreductase FX981_02484 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FX981_02486 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) FX981_02492 ENOG4105QBX endodeoxyribonuclease RusA FX981_02496 ENOG4105IG6 Phage terminase, large subunit FX981_02497 ENOG4108MDF Phage Portal Protein FX981_02502 ENOG41060SN FX981_02504 ENOG4105PQS phage protein FX981_02505 ENOG4105FR7 XkdM protein, phage-like element PBSX FX981_02506 ENOG4105MTC XkdN-like protein FX981_02508 ENOG4108FKH Transglycosylase SLT domain FX981_02508 ENOG4108FKH Transglycosylase SLT domain FX981_02509 ENOG4108WZM domain protein FX981_02510 ENOG4105X7F FX981_02512 ENOG4105MFU Protein of unknown function (DUF2634) FX981_02513 ENOG41066EA baseplate J family protein FX981_02514 ENOG410906S phage-like element pbsx protein xkdt FX981_02518 ENOG41068G1 FX981_02521 ENOG41068G1 FX981_02526 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FX981_02528 ENOG4105TRT Transcriptional regulator FX981_02529 ENOG4105C26 Dehydrogenase FX981_02530 ENOG4108JB8 alcohol dehydrogenase FX981_02531 ENOG4106DF1 FX981_02533 ENOG4105DZ6 Band 7 protein FX981_02534 ENOG4105CNI cell division protein FtsW FX981_02535 ENOG4105CNI cell division protein FtsW FX981_02537 ENOG4105VRR gCN5-related N-acetyltransferase FX981_02539 ENOG4105N67 Proton-coupled thiamine transporter YuaJ FX981_02564 ENOG4108606 TspO/MBR family FX981_02566 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FX981_02567 ENOG4105E4F Isochorismate synthase FX981_02568 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) FX981_02569 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) FX981_02570 ENOG4108IPT Naphthoate synthase FX981_02572 ENOG4105DTQ mandelate racemase muconate lactonizing FX981_02578 ENOG4105DSE periplasmic solute binding protein FX981_02579 ENOG4108V2W Carbonate dehydratase FX981_02580 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) FX981_02581 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) FX981_02584 ENOG4108RMU ferritin dps family protein FX981_02589 ENOG4106FN3 tellurium resistance protein FX981_02591 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component FX981_02593 ENOG4105D2X ABC transporter substrate-binding protein FX981_02597 ENOG4105EWK phytoene FX981_02601 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FX981_02602 ENOG4105CAQ asparagine synthetase FX981_02603 ENOG4108Z0R Transferase FX981_02604 ENOG4105E8V Alpha Beta Hydrolase Fold protein FX981_02607 ENOG4105N5T Radical SAM Protein FX981_02610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family FX981_02611 ENOG4105DVE abc transporter atp-binding protein FX981_02613 ENOG4105C19 ABC transporter FX981_02614 ENOG4107R34 abc transporter permease protein FX981_02615 ENOG4106UBQ FX981_02616 ENOG4105BZU Histidine kinase FX981_02618 ENOG4105C8T Leucyl-tRNA synthetase FX981_02619 ENOG4105NTD Inherit from COG: Hydrolase FX981_02621 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component FX981_02623 ENOG4105CV8 reductase FX981_02624 ENOG4105F27 Major Facilitator FX981_02625 ENOG4105KVH Transcriptional regulator FX981_02626 ENOG41075H3 AraC family transcriptional regulator FX981_02628 ENOG4105F5H Glycosyl Hydrolase Family 88 FX981_02630 ENOG4105DDC Oxidoreductase domain protein FX981_02631 ENOG4105MU9 integral membrane protein FX981_02632 ENOG41085GJ domain protein FX981_02634 ENOG4106611 bacteriocin immunity FX981_02635 ENOG4105C94 Transporter FX981_02637 ENOG4105CBX hi0933 family FX981_02640 ENOG4105YW5 deoR family transcriptional regulator FX981_02641 ENOG4105C7N Xanthine uracil vitamin C permease FX981_02642 ENOG4107QSE Dipeptidase FX981_02643 ENOG4107UIE peptidase FX981_02644 ENOG4105C6T cysteine synthase FX981_02645 ENOG4107F58 2'-5' rna ligase FX981_02648 ENOG4108V15 phosphotransferase enzyme family FX981_02650 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) FX981_02651 ENOG4105C8F Beta-lactamase domain protein FX981_02652 ENOG4105C6K Malic enzyme FX981_02655 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ FX981_02658 ENOG4108NKM UPF0354 protein FX981_02659 ENOG4108VDD TRNA binding domain protein FX981_02661 ENOG4105DFU Cell wall formation (By similarity) FX981_02665 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase FX981_02666 ENOG4105ETE Transcriptional regulator (LacI family FX981_02667 ENOG4105DGU Histone deacetylase FX981_02668 ENOG4105W87 Cbs domain FX981_02669 ENOG4105F1V Acetoin utilization protein FX981_02671 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) FX981_02672 ENOG4105KAC Antibiotic biosynthesis monooxygenase FX981_02673 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold FX981_02679 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FX981_02681 ENOG4105U5Y Transcriptional regulator FX981_02687 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) FX981_02689 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FX981_02690 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FX981_02693 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) FX981_02695 ENOG4105C19 ABC transporter FX981_02696 ENOG4105EWM Histidine kinase FX981_02698 ENOG4108V5C ABC transporter FX981_02699 ENOG4108S01 response regulator FX981_02700 ENOG4108ZGX Histidine kinase FX981_02701 ENOG4105ECK Fatty Acid Desaturase FX981_02702 ENOG4105C1J atp-dependent rna helicase FX981_02703 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) FX981_02704 ENOG4105D07 Signal peptide peptidase, SppA FX981_02705 ENOG4105VK3 rdd domain containing protein FX981_02707 ENOG4105KBJ sporulation protein ytfj FX981_02708 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FX981_02710 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FX981_02711 ENOG4105EPU Molybdenum cofactor synthesis domain protein FX981_02712 ENOG4105CDH Citrulline--aspartate ligase FX981_02713 ENOG4105CH7 arginosuccinase FX981_02716 ENOG4105E8R UPF0173 metal-dependent hydrolase FX981_02719 ENOG4105SFS phosphoesterase RecJ domain protein FX981_02720 ENOG4106EVM FX981_02722 ENOG4105VV2 FX981_02723 ENOG4105C0B DNA polymerase III (alpha subunit) FX981_02724 ENOG4105C6K Malic enzyme FX981_02725 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) FX981_02727 ENOG4105CTQ phosphohexokinase FX981_02728 ENOG4105CA9 Pyruvate kinase FX981_02729 ENOG4105FS0 cytoplasmic membrane protein FX981_02730 ENOG4108REF Sporulation integral membrane protein ytvi FX981_02731 ENOG4107CWS Protein of unknown function (DUF441) FX981_02732 ENOG4105BZN citrate synthase FX981_02733 ENOG4108HMX isocitrate dehydrogenase (NADP) FX981_02734 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) FX981_02735 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FX981_02736 ENOG4105BZU Histidine kinase FX981_02737 ENOG4105C2M dna polymerase I FX981_02738 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) FX981_02740 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FX981_02741 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FX981_02742 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) FX981_02744 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) FX981_02748 ENOG4108TDW sporulation protein YtxC FX981_02749 ENOG4105C22 threonyL-tRNA synthetase FX981_02750 ENOG4107SDU Methyl-accepting chemotaxis FX981_02751 ENOG4105U0R haloacid dehalogenase-like hydrolase FX981_02752 ENOG4108HRK Histidine kinase FX981_02753 ENOG4105DY9 regulatoR FX981_02755 ENOG41067MG lrgb family FX981_02756 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) FX981_02757 ENOG4105VJV 50s ribosomal protein L35 FX981_02758 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FX981_02759 ENOG410696E Membrane FX981_02761 ENOG4105CN9 Peptidase m42 family protein FX981_02763 ENOG41067MF small acid-soluble spore protein FX981_02764 ENOG4108RWN rrna methyltransferase FX981_02765 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) FX981_02766 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FX981_02767 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FX981_02768 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) FX981_02770 ENOG4105DCG PHP domain protein FX981_02771 ENOG4105C98 muts2 protein FX981_02774 ENOG4105CEY Amp-dependent synthetase and ligase FX981_02775 ENOG4107Z3H Transcriptional regulator, TetR family FX981_02776 ENOG41060WC Enoyl-CoA hydratase FX981_02777 ENOG4105BZJ Electron transfer flavoprotein FX981_02778 ENOG4105C10 Electron transfer flavoprotein FX981_02779 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) FX981_02780 ENOG4105K63 Thioredoxin FX981_02781 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) FX981_02782 ENOG4105CFH Aspartokinase FX981_02784 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit FX981_02786 ENOG4105E33 succinate dehydrogenase FX981_02788 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FX981_02789 ENOG4105C7F AcnD-accessory protein PrpF FX981_02790 ENOG4108KAM Transcriptional regulator FX981_02792 ENOG4105PFC Transcriptional regulator FX981_02793 ENOG41067TZ transcriptional regulator, MarR family FX981_02794 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) FX981_02795 ENOG4108XJQ germination protein FX981_02796 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) FX981_02797 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FX981_02798 ENOG4105M59 Phosphodiesterase, mj0936 family FX981_02801 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FX981_02810 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) FX981_02811 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein FX981_02813 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD FX981_02815 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) FX981_02816 ENOG4105CM2 brancheD-chain amino acid aminotransferase FX981_02817 ENOG4105C7K acetolactate synthase FX981_02818 ENOG4108ZP8 Acetolactate synthase small subunit FX981_02819 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase FX981_02820 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) FX981_02821 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FX981_02822 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FX981_02823 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) FX981_02825 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation FX981_02826 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) FX981_02827 ENOG4108IUQ atp-dependent protease FX981_02828 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FX981_02829 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) FX981_02831 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FX981_02833 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) FX981_02835 ENOG4105D52 delta-aminolevulinic acid dehydratase FX981_02836 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase FX981_02837 ENOG41068KH stage VI sporulation protein D FX981_02838 ENOG4106AR7 Spore coat protein FX981_02840 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FX981_02841 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FX981_02842 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FX981_02844 ENOG4108Z03 MAF-like protein FX981_02845 ENOG4105W5Q DNA repair protein (RadC FX981_02846 ENOG4105DFF Rod shape-determining protein mreb FX981_02847 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FX981_02848 ENOG4105YHC Rod shape-determining protein MreD FX981_02849 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) FX981_02850 ENOG4107QMS site-determining protein FX981_02853 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) FX981_02854 ENOG4105X36 (ribosomal) protein FX981_02855 ENOG4105K46 50S ribosomal protein l27 FX981_02857 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FX981_02859 ENOG4105CQC Prephenate dehydratase FX981_02862 ENOG4108IYU L-aspartate oxidase FX981_02863 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FX981_02864 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) FX981_02865 ENOG4106678 morphogenetic protein associated with SpoVID FX981_02865 ENOG4106678 morphogenetic protein associated with SpoVID FX981_02868 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) FX981_02873 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) FX981_02874 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) FX981_02875 ENOG41061AI Protein of unknown function (DUF2905) FX981_02876 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) FX981_02877 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) FX981_02878 ENOG4105VIE preprotein translocase, subunit YajC FX981_02879 ENOG4105NAP FX981_02880 ENOG4108QG2 Membrane FX981_02881 ENOG4105CKP Polysaccharide Biosynthesis Protein FX981_02883 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FX981_02884 ENOG4105NCW Trka-c domain protein FX981_02885 ENOG41067VP Protein of unknown function (DUF1049) FX981_02886 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FX981_02887 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) FX981_02888 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FX981_02889 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) FX981_02890 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FX981_02892 ENOG4105CUT histidyl-tRNA synthetase FX981_02893 ENOG4105C9M aspartyl-trna synthetase FX981_02894 ENOG4105CUZ uba thif-type nad fad binding protein FX981_02895 ENOG4105D1H recombination factor protein RarA FX981_02897 ENOG4105C3J Cysteine desulfurase FX981_02898 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) FX981_02900 ENOG4105C7H Helicase, RecD TraA family FX981_02902 ENOG41060CR FX981_02904 ENOG4105DRP amino acid AbC transporter FX981_02905 ENOG4105EAD ABC transporter FX981_02906 ENOG4105CT1 (ABC) transporter FX981_02907 ENOG4105CDA abc transporter atp-binding protein FX981_02908 ENOG4105C02 permease FX981_02910 ENOG4105VBH UPF0297 protein FX981_02911 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) FX981_02912 ENOG4105VPH UPF0473 protein FX981_02913 ENOG4107ZYJ bioY protein FX981_02914 ENOG4107F3J Amp-dependent synthetase and ligase FX981_02916 ENOG4105HHA aminodeoxychorismate lyase FX981_02917 ENOG4108VQJ O-methyltransferase FX981_02918 ENOG4105XYU peptidase (U32 family) FX981_02919 ENOG4105CFP Peptidase U32 FX981_02920 ENOG4107S03 uridine kinase FX981_02922 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FX981_02923 ENOG4107XRG penicillin-binding protein FX981_02926 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) FX981_02927 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) FX981_02929 ENOG4105C28 cystathionine FX981_02935 ENOG4105E2A Dehydrogenase FX981_02936 ENOG41089UC methyltransferase, type 11 FX981_02937 ENOG4105CJ1 ABC, transporter FX981_02938 ENOG41090VJ ABC-2 type transporter FX981_02939 ENOG4108KYE ABC-2 type transporter FX981_02940 ENOG4107EXU Short-chain dehydrogenase reductase Sdr FX981_02943 ENOG4105WEF catalase FX981_02944 ENOG4105E5Q amino acid AbC transporter FX981_02948 ENOG4105FDT acyl-CoA dehydrogenase FX981_02949 ENOG4108HWY Beta-lactamase FX981_02956 ENOG4105KVH Transcriptional regulator FX981_02957 ENOG4108VA3 3-hexulose-6-phosphate synthase FX981_02958 ENOG41080HJ 6-phospho 3-hexuloisomerase FX981_02960 ENOG4105CMD Transcriptional regulator, GntR family FX981_02963 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FX981_02964 ENOG4107QNK )-transporter FX981_02969 ENOG4108ZJ4 polysaccharide deacetylase FX981_02975 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX981_02980 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase FX981_02981 ENOG4105CQW ribosome biogenesis GTPase YqeH FX981_02982 ENOG4105E2X shikimate dehydrogenase FX981_02983 ENOG410812S Rna-binding protein FX981_02984 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) FX981_02985 ENOG4108WF2 Metal Dependent Phosphohydrolase FX981_02987 ENOG4108D32 Methyltransferase FX981_02989 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FX981_02990 ENOG4108UK2 deaminase FX981_02991 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 FX981_02993 ENOG4105TQK DNA polymerase iii, delta' subunit FX981_02996 ENOG4108ZRV stage ii sporulation protein p FX981_02998 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) FX981_02999 ENOG4105CSA Coproporphyrinogen iii oxidase FX981_03000 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) FX981_03001 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ FX981_03003 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FX981_03004 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) FX981_03005 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FX981_03006 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FX981_03009 ENOG4105KTH gatB Yqey FX981_03010 ENOG4105F7J membrane-bound serine protease FX981_03011 ENOG4105DI5 UPF0365 protein FX981_03013 ENOG41068P3 sporulation protein YqfC FX981_03014 ENOG4105EI1 sporulation protein yqfd FX981_03015 ENOG4105C9A Phoh family FX981_03016 ENOG4105CTJ Metal Dependent Phosphohydrolase FX981_03017 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) FX981_03018 ENOG4107YR5 Diacylglycerol kinase FX981_03019 ENOG4105KG3 cytidine deaminase FX981_03020 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) FX981_03022 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) FX981_03023 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FX981_03024 ENOG4105C38 Glycyl-tRNA synthetase beta subunit FX981_03026 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) FX981_03027 ENOG4108UPT UPF0178 protein FX981_03028 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FX981_03029 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX981_03032 ENOG4105EGD dinuclear metal center protein, YbgI family FX981_03033 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) FX981_03036 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FX981_03037 ENOG41069ZM Protein of unknown function (DUF2624) FX981_03038 ENOG4108JYZ YitT family FX981_03039 ENOG4105FDK ABC transporter FX981_03040 ENOG4105FAV ABC, transporter FX981_03041 ENOG4105N80 Ferric uptake regulator, Fur family FX981_03042 ENOG41066F8 ROK family FX981_03043 ENOG4108U5J '-nucleotidase FX981_03044 ENOG41063Y9 FX981_03045 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) FX981_03047 ENOG4105D9U N-acetyltransferase FX981_03049 ENOG4105SXS Protein of unknown function (DUF456) FX981_03050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FX981_03052 ENOG4107RF6 penicillin-binding protein FX981_03053 ENOG4105CVA phosphate FX981_03054 ENOG4105C8U phosphate abc transporter FX981_03055 ENOG4105E2Z phosphate ABC transporter (Permease FX981_03056 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FX981_03057 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FX981_03058 ENOG41068DG YceG-like family FX981_03060 ENOG4105WDJ 50S ribosomal protein L33 FX981_03061 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FX981_03065 ENOG4107ZXI Rhomboid family FX981_03068 ENOG4105E0M Sulfatase FX981_03073 ENOG4105C5X domain protein FX981_03080 ENOG4106855 Competence protein FX981_03088 ENOG4105VFR signal peptidase FX981_03093 ENOG4105C0D helicase FX981_03094 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) FX981_03096 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor FX981_03097 ENOG4105WZW rhodanese family FX981_03098 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) FX981_03099 ENOG4105KST dependent repressor FX981_03102 ENOG4105CBJ Metal-dependent enzyme FX981_03104 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) FX981_03105 ENOG4105DC7 peptidase M24 FX981_03106 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) FX981_03108 ENOG4105CD2 stage iii sporulation protein aa FX981_03109 ENOG4105KR5 Stage iii sporulation protein FX981_03110 ENOG4108CQH stage III sporulation protein AC FX981_03111 ENOG4105KQ4 Stage iii sporulation protein ad FX981_03113 ENOG410644B Stage III sporulation protein af FX981_03117 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FX981_03118 ENOG4108ZSR alkaline shock protein FX981_03119 ENOG4105M7K Involved in the transcription termination process (By similarity) FX981_03120 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) FX981_03121 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FX981_03122 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) FX981_03123 ENOG4105CTB Polyprenyl synthetase FX981_03124 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) FX981_03125 ENOG4105DX0 Hemolysin A FX981_03126 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) FX981_03127 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FX981_03128 ENOG4105S1Z Stage IV sporulation protein B FX981_03129 ENOG4107QQR Sporulation FX981_03133 ENOG4108QXE glycerophosphoryl diester phosphodiesterase FX981_03134 ENOG4106CCJ Protein of unknown function (DUF2627) FX981_03135 ENOG4108JUB Transcriptional regulator FX981_03137 ENOG4107RDP Dehydrogenase FX981_03138 ENOG4105CKM Branched-chain carboxylic acid kinase FX981_03141 ENOG4105CPP Dehydrogenase, E1 component FX981_03142 ENOG4105C7S Dehydrogenase FX981_03144 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) FX981_03145 ENOG4108Y6J UPF0403 protein FX981_03146 ENOG4108HW3 (ABC) transporter FX981_03147 ENOG4105E5Q amino acid AbC transporter FX981_03148 ENOG4105CDA abc transporter atp-binding protein FX981_03149 ENOG4108QEG Membrane FX981_03150 ENOG4108VZI ErfK ybiS ycfS ynhG family protein FX981_03151 ENOG4108ZVT methylmalonyl-coA epimerase FX981_03152 ENOG4108HNZ carboxyl transferase FX981_03153 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) FX981_03155 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) FX981_03158 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FX981_03159 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FX981_03160 ENOG4105CSC Glucose uptake protein FX981_03161 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FX981_03162 ENOG4105VZJ PTS System FX981_03163 ENOG4105VCP PTS System FX981_03164 ENOG4105CK1 PTS System FX981_03165 ENOG4105CS2 ec 3.2.1.21 FX981_03166 ENOG4108TZY GntR Family Transcriptional Regulator FX981_03167 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FX981_03168 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) FX981_03169 ENOG4105XT2 Transcriptional regulator FX981_03171 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FX981_03173 ENOG4105D4P Coproporphyrinogen iii oxidase FX981_03177 ENOG4105II7 pyrroline-5-carboxylate reductase FX981_03178 ENOG41069FQ Metallo-beta-lactamase superfamily FX981_03179 ENOG4108IXY short-chain dehydrogenase reductase FX981_03180 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase FX981_03182 ENOG4105E5W Transporter FX981_03184 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FX981_03186 ENOG4108XET gCN5-related N-acetyltransferase FX981_03187 ENOG4105RHY Pfam:UPF0157 FX981_03188 ENOG4106HZJ FX981_03194 ENOG4105CPC Aldo Keto reductase FX981_03195 ENOG4108YZ4 nudix hydrolase FX981_03197 ENOG4107YB6 acetyltransferase, (GNAT) family FX981_03200 ENOG4105MZ9 stage II sporulation protein m FX981_03201 ENOG4105I3K Ferric uptake regulator, Fur family FX981_03203 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FX981_03204 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FX981_03205 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FX981_03206 ENOG4105DZ1 carboxypeptidase FX981_03207 ENOG41082AN stage II sporulation protein FX981_03208 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) FX981_03209 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX981_03212 ENOG41090VF Stage v sporulation protein ac FX981_03213 ENOG4105CZ3 stage V sporulation protein ad FX981_03215 ENOG4105G6R Stage v sporulation protein ae FX981_03217 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FX981_03218 ENOG4105PTM secreted protein FX981_03219 ENOG4107ZE5 PPIases accelerate the folding of proteins FX981_03224 ENOG4108R6K riboflavin synthase, subunit alpha FX981_03225 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) FX981_03226 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FX981_03230 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) FX981_03231 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) FX981_03233 ENOG4105DZ1 carboxypeptidase FX981_03234 ENOG4108JIC nucleoside recognition domain protein FX981_03236 ENOG4105FE9 pseudouridine synthase FX981_03238 ENOG4107TWT Cytochrome c biogenesis protein FX981_03239 ENOG4105CRE cytochrome C FX981_03240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX981_03241 ENOG4105BZU Histidine kinase FX981_03244 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase FX981_03245 ENOG4108JQ1 Dehydrogenase FX981_03246 ENOG4108SAX Membrane FX981_03248 ENOG4105T7X FX981_03249 ENOG4105C9U ATP-dependent DNA helicase RecQ FX981_03250 ENOG4105I7S Abortive infection protein FX981_03253 ENOG4107RGJ metallophosphoesterase FX981_03256 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase FX981_03257 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) FX981_03259 ENOG4105MSI germination protein ypeb FX981_03262 ENOG4105CAT Cytidine monophosphate kinase FX981_03263 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FX981_03267 ENOG4105S2F FX981_03268 ENOG41065D1 FX981_03269 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) FX981_03270 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase FX981_03273 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) FX981_03274 ENOG4105K70 DNA-binding protein FX981_03275 ENOG4105EUJ GTP cyclohydrolase i FX981_03277 ENOG4105XXQ heptaprenyl diphosphate synthase component I FX981_03278 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) FX981_03279 ENOG4105EAH synthase FX981_03280 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) FX981_03281 ENOG4105BZU Histidine kinase FX981_03282 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase FX981_03283 ENOG4105D49 3-dehydroquinate synthase FX981_03284 ENOG4105KHN chorismate mutase FX981_03287 ENOG4105DK0 Indole-3-glycerol phosphate synthase FX981_03288 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase FX981_03289 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) FX981_03290 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) FX981_03291 ENOG4105CIH Imidazole acetol-phosphate transaminase FX981_03293 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase FX981_03294 ENOG41068YB TPR repeat-containing protein FX981_03295 ENOG4108SXZ UPF0302 protein FX981_03298 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) FX981_03302 ENOG4108JYZ YitT family FX981_03303 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase FX981_03304 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) FX981_03305 ENOG4108Z5K methylglyoxal synthase FX981_03306 ENOG4105FJR Lmbe family FX981_03307 ENOG4105CPK Glycosyl transferase (Group 1 FX981_03308 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate FX981_03310 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) FX981_03311 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) FX981_03312 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) FX981_03313 ENOG4105DVT helicase FX981_03314 ENOG4105YAC FX981_03318 ENOG4105CSM endonuclease III FX981_03320 ENOG4105BZ4 penicillin-binding protein FX981_03321 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) FX981_03329 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FX981_03330 ENOG4108I5C dEAD DEAH box helicase FX981_03331 ENOG4107X2U Inherit from COG: Exonuclease-like protein FX981_03334 ENOG4108UKS UPF0398 protein FX981_03335 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) FX981_03336 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FX981_03338 ENOG4105DVT helicase FX981_03339 ENOG4105CTD carboxy-peptidase FX981_03341 ENOG4105C2W permease FX981_03342 ENOG4107VMI polysaccharide deacetylase FX981_03344 ENOG41065KQ synthase FX981_03346 ENOG410890F Dynamin family FX981_03351 ENOG41081VK Ribonuclease FX981_03358 ENOG4108QBV Monogalactosyldiacylglycerol synthase FX981_03359 ENOG4105CVG Homoserine O-transsuccinylase FX981_03360 ENOG4105CKU formyltetrahydrofolate synthetase FX981_03361 ENOG4108V06 Glutathione peroxidase FX981_03364 ENOG4105C01 Dihydroxy-acid dehydratase FX981_03365 ENOG4108Y6J UPF0403 protein FX981_03366 ENOG4107YX5 Pfam:DUF548 FX981_03369 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) FX981_03370 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FX981_03372 ENOG4108UT2 hemolysin iii FX981_03374 ENOG4105C7B Threonine dehydratase FX981_03377 ENOG4108KF3 Electron transport protein SCO1 SenC FX981_03378 ENOG41090WU lipolytic protein G-D-S-L family FX981_03379 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) FX981_03384 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) FX981_03385 ENOG4105E0X reductase FX981_03386 ENOG4105C5E polysaccharide biosynthesis protein FX981_03392 ENOG4108JUB Transcriptional regulator FX981_03393 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FX981_03395 ENOG4105VSD UPF0346 protein FX981_03398 ENOG410841Q phosphoesterase PA-phosphatase related protein FX981_03399 ENOG4106Z5R FX981_03400 ENOG4105D3A purine nucleoside phosphorylase DeoD-type FX981_03401 ENOG4108VXD carboxy-peptidase FX981_03405 ENOG4105E1V na solute symporter FX981_03411 ENOG4105FR1 rard protein FX981_03415 ENOG4107QMU Mate efflux family protein FX981_03418 ENOG4105K4H Nlp p60 protein FX981_03420 ENOG4105GMT ATPase associated with various cellular activities aaa_5 FX981_03421 ENOG4107T89 von Willebrand factor, type A FX981_03422 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FX981_03423 ENOG4105C7S Dehydrogenase FX981_03424 ENOG4105C09 Bile acid FX981_03425 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FX981_03426 ENOG4105EWU Squalene--hopene cyclase FX981_03427 ENOG4105C26 Dehydrogenase FX981_03432 ENOG4105SCY DNAK suppressor FX981_03433 ENOG4105C9U ATP-dependent DNA helicase RecQ FX981_03434 ENOG41069ER domain protein FX981_03436 ENOG4108SJC Membrane FX981_03438 ENOG4105DXD 2-methylcitrate dehydratase FX981_03439 ENOG4105CR4 methylisocitrate lyase FX981_03441 ENOG4105CUB amino acid FX981_03442 ENOG4105KTU Transcriptional regulator, arsr family FX981_03444 ENOG4105D29 Helix-turn-helix type 11 domain protein FX981_03446 ENOG4108W8B Beta-lactamase domain protein FX981_03450 ENOG4105FVX FX981_03452 ENOG4108Z7R Chaperone CsaA FX981_03453 ENOG4105CT4 transporter FX981_03457 ENOG4105CMG Carbohydrate kinase FX981_03459 ENOG4108J2R molybdopterin oxidoreductase FX981_03462 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) FX981_03463 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) FX981_03464 ENOG4108UYN gCN5-related N-acetyltransferase FX981_03465 ENOG41090E6 transcriptional regulator MERR family FX981_03466 ENOG4105BZ1 (ABC) transporter FX981_03468 ENOG4105C5Q Transcriptional regulator FX981_03469 ENOG4105CBC glutamate synthase FX981_03470 ENOG4105BZ8 glutamate synthase FX981_03473 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) FX981_03474 ENOG4108IFG nitrite reductase, (NAD(P)H) FX981_03475 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit FX981_03476 ENOG4105H67 Protein of unknown function (DUF421) FX981_03477 ENOG4105NBR Pectinesterase FX981_03478 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family FX981_03479 ENOG4107QJQ Mate efflux family protein FX981_03482 ENOG4105DEN Luciferase family FX981_03484 ENOG4105EXQ uroporphyrinogen iii synthase hem4 FX981_03485 ENOG4107T5V SNARE associated Golgi FX981_03486 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FX981_03492 ENOG4108B31 Spore germination protein FX981_03495 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FX981_03496 ENOG4105CQB FAD linked oxidase domain protein FX981_03501 ENOG4105F32 YngK protein FX981_03502 ENOG4105C1G acyl-Coa dehydrogenase FX981_03503 ENOG4105CEY Amp-dependent synthetase and ligase FX981_03504 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FX981_03505 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit FX981_03506 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase FX981_03507 ENOG4105E39 Enoyl-CoA hydratase FX981_03508 ENOG4107QX3 carboxylase FX981_03509 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FX981_03511 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FX981_03513 ENOG4105C26 Dehydrogenase FX981_03517 ENOG4107RZC phospholipase d FX981_03518 ENOG4105HX0 Transcriptional regulator FX981_03519 ENOG4105DE4 1-phosphofructokinase FX981_03520 ENOG4105DM4 PTS System FX981_03521 ENOG4105DM4 PTS System FX981_03533 ENOG4107EFR Flavocytochrome c FX981_03534 ENOG4108KAM Transcriptional regulator FX981_03535 ENOG4106ETB IIa component FX981_03538 ENOG4105UP7 3-epimerase FX981_03541 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component FX981_03542 ENOG4105I1K ABC transporter FX981_03545 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) FX981_03546 ENOG4107QNK )-transporter FX981_03547 ENOG4105D2N Aldolase FX981_03549 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) FX981_03550 ENOG4105DH8 myo-inositol catabolism FX981_03553 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) FX981_03554 ENOG4107SYN Glycosyl hydrolases family 43 FX981_03556 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FX981_03560 ENOG4105C5Y PTS System FX981_03561 ENOG4105CS2 ec 3.2.1.21 FX981_03562 ENOG4108Z6Z Transcriptional regulator FX981_03565 ENOG4105ES4 Nitrilase FX981_03566 ENOG4105N0V mono-oxygenase ydhR FX981_03567 ENOG4106H6A FX981_03572 ENOG4107RQD Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid (By similarity) FX981_03575 ENOG4105KME endoribonuclease L-psp FX981_03576 ENOG4105C6T cysteine synthase FX981_03577 ENOG4105EYF MMPL domain protein FX981_03578 ENOG4105ENE Histidine kinase FX981_03579 ENOG4108VB1 regulatoR FX981_03580 ENOG4105ID8 Transcriptional regulator, ARAC family FX981_03581 ENOG4105DET Rhamnulokinase FX981_03582 ENOG4105DKG l-rhamnose isomerase FX981_03584 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FX981_03585 ENOG4107QR9 Iron-sulfur cluster binding protein FX981_03588 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) FX981_03589 ENOG4105E98 transcriptional regulator DeoR family FX981_03590 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) FX981_03591 ENOG4105C26 Dehydrogenase FX981_03592 ENOG4105KVH Transcriptional regulator FX981_03593 ENOG4105DYS nad(p)h dehydrogenase (quinone) FX981_03594 ENOG4108UW5 maltose o-acetyltransferase FX981_03595 ENOG4106UW1 Major Facilitator superfamily FX981_03599 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX981_03600 ENOG4105K4P CoA-binding domain protein FX981_03601 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) FX981_03602 ENOG4105W8X HesB YadR YfhF-family protein FX981_03603 ENOG4105MI2 FX981_03608 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FX981_03609 ENOG4108I0Z Aconitate hydratase FX981_03615 ENOG4107QIV Cytochrome c biogenesis protein FX981_03616 ENOG4105VXM UPF0154 protein FX981_03618 ENOG4105CV1 Transketolase (EC 2.2.1.1) FX981_03619 ENOG4105VPS UPF0291 protein FX981_03620 ENOG4108SVB resolvase FX981_03622 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FX981_03624 ENOG4106SCS STAS domain FX981_03625 ENOG4105WFK nuclease FX981_03626 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases FX981_03627 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FX981_03628 ENOG41082JN Transcriptional regulator FX981_03629 ENOG4108QY0 Membrane FX981_03633 ENOG4105ECR NmrA family FX981_03634 ENOG4108Z40 Transcriptional regulator FX981_03635 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) FX981_03636 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) FX981_03637 ENOG4105FDF Could be involved in DNA repair (By similarity) FX981_03638 ENOG4105DQE DNA ligase FX981_03639 ENOG4105XPP Protein of unknown function (DUF1275) FX981_03641 ENOG410780I phosphoprotein phosphatase activity FX981_03642 ENOG4108ZMX Domain of unknown function (DU1801) FX981_03648 ENOG410780I phosphoprotein phosphatase activity FX981_03653 ENOG4106CGH Phage Mu protein F like protein FX981_03656 ENOG4105DQ6 Transposase FX981_03663 ENOG4105C5F glutamine synthetase FX981_03664 ENOG4105KV4 Transcriptional regulator FX981_03665 ENOG4105CXI aluminum resistance protein FX981_03666 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FX981_03667 ENOG4106F1P AAA ATPase, central domain protein FX981_03668 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FX981_03669 ENOG4105U6W MutT NUDIX family protein FX981_03670 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FX981_03671 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FX981_03672 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FX981_03676 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) FX981_03681 ENOG410814C multidrug resistance protein FX981_03682 ENOG4108X3M OsmC Ohr family protein FX981_03683 ENOG4105K7W phage-related replication protein FX981_03684 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin FX981_03686 ENOG4105K7W phage-related replication protein FX981_03687 ENOG4108VJ1 Transcriptional regulator (CarD family FX981_03690 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) FX981_03691 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) FX981_03694 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) FX981_03695 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FX981_03696 ENOG4105CPQ Dehydrogenase FX981_03698 ENOG4105MCT stage V sporulation protein S FX981_03699 ENOG4105D48 metallophosphoesterase FX981_03700 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) FX981_03701 ENOG4108A04 Beta-lactamase FX981_03703 ENOG4105CEV competence damage-inducible protein FX981_03704 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FX981_03707 ENOG4105XZV Protein of unknown function (DUF3243) FX981_03708 ENOG4108RKS Short-chain dehydrogenase reductase Sdr FX981_03709 ENOG4105EYF MMPL domain protein FX981_03713 ENOG4105EYF MMPL domain protein FX981_03715 ENOG4105FDP GntR family transcriptional regulator FX981_03716 ENOG4105CNU cell division protein FtsK FX981_03718 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit FX981_03720 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FX981_03722 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FX981_03723 ENOG4108S0H Dipicolinic acid synthetase, b subunit FX981_03724 ENOG4105E35 Dipicolinate synthase subunit A FX981_03727 ENOG4105C1V Peptidase, M16 FX981_03729 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) FX981_03730 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) FX981_03731 ENOG4105DTN riboflavin biosynthesis protein ribF FX981_03732 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FX981_03733 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) FX981_03734 ENOG4105W7A Protein of unknown function (DUF503) FX981_03735 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) FX981_03736 ENOG4105VHM ribosomal protein FX981_03737 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination FX981_03738 ENOG4105CHV Transcription elongation factor NusA FX981_03739 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) FX981_03740 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FX981_03748 ENOG4105CJ1 ABC, transporter FX981_03752 ENOG4105WJF FX981_03753 ENOG4105CYP glycoside hydrolase, family FX981_03755 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) FX981_03756 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) FX981_03757 ENOG4105DZP Membrane-associated zinc metalloprotease FX981_03758 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FX981_03759 ENOG4105KNE Phosphatidate cytidylyltransferase FX981_03760 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FX981_03761 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) FX981_03763 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) FX981_03764 ENOG4105CE9 30S ribosomal protein S2 FX981_03766 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX981_03767 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) FX981_03769 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis FX981_03770 ENOG4105CBS Chea signal transduction histidine kinase FX981_03771 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FX981_03773 ENOG4105FZW flagellar biosynthesis regulator FlhF FX981_03774 ENOG4105D7B Flagellar biosynthesis protein flha FX981_03775 ENOG4105D00 flagellar biosynthetic protein flhB FX981_03776 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FX981_03777 ENOG4105VS8 Flagellar biosynthetic protein fliq FX981_03778 ENOG4105CN7 Flagellar biosynthetic protein FliP FX981_03780 ENOG4107YTP response regulator receiver protein FX981_03781 ENOG4105DD5 Flagellar motor switch protein FX981_03782 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FX981_03784 ENOG41068WV flagellar FlbD family protein FX981_03785 ENOG4108JQA flagellar FX981_03786 ENOG410822I Flagellar hook capping protein FX981_03787 ENOG410696Y Flagellar hook-length control protein FX981_03789 ENOG4106YF4 Flagellar biosynthesis chaperone FX981_03792 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FX981_03793 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FX981_03794 ENOG4105VQ0 flagellar hook-basal body complex protein fliE FX981_03795 ENOG4108ZC9 flagellar basal-body rod protein flgc FX981_03796 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FX981_03798 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FX981_03799 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) FX981_03800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FX981_03801 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) FX981_03802 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FX981_03803 ENOG4105C79 DNA protecting protein DprA FX981_03804 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FX981_03805 ENOG4105CMV Succinyl-CoA synthetase subunit beta FX981_03806 ENOG4105VM1 flagellar FX981_03808 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) FX981_03809 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) FX981_03810 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) FX981_03811 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) FX981_03812 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) FX981_03814 ENOG4108BW8 UPF0109 protein FX981_03815 ENOG4105K5M 30s ribosomal protein S16 FX981_03817 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) FX981_03818 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FX981_03819 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) FX981_03820 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) FX981_03821 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FX981_03822 ENOG4105CHR reductase FX981_03823 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FX981_03824 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) FX981_03825 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) FX981_03826 ENOG4105CB5 ATP-dependent DNA helicase recG FX981_03827 ENOG4105EJQ L-serine dehydratase FX981_03829 ENOG4105DP4 dak2 domain fusion protein ylov FX981_03830 ENOG4108ZAA Alkaline-shock protein FX981_03831 ENOG4105VB9 50S ribosomal protein l28 FX981_03832 ENOG4105FJ0 thiamine FX981_03833 ENOG4105DJV ribulose-phosphate 3-epimerase FX981_03834 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) FX981_03835 ENOG4105D9P serine threonine protein kinase FX981_03836 ENOG4108ZF3 Phosphatase FX981_03837 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs FX981_03838 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B FX981_03839 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) FX981_03840 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) FX981_03841 ENOG4105C25 Primosomal protein n' FX981_03842 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FX981_03844 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FX981_03845 ENOG4105KC4 UPF0296 protein FX981_03846 ENOG4105DSJ YicC domain protein FX981_03848 ENOG4105F23 Fibronectin-binding protein FX981_03849 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein FX981_03850 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein FX981_03851 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) FX981_03852 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) FX981_03853 ENOG4107RIQ Sulfate adenylate transferase FX981_03855 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity)