locus-tag class description BSA41_00040 ENOG4108IUW ABC transporter BSA41_00055 ENOG4105SX7 Transporter BSA41_00080 ENOG4105CDA abc transporter atp-binding protein BSA41_00085 ENOG4105DRP amino acid AbC transporter BSA41_00095 ENOG4108IQI permease BSA41_00100 ENOG4105CT4 transporter BSA41_00105 ENOG4105DMW Dehydrogenase reductase BSA41_00110 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BSA41_00115 ENOG4107XBN GntR Family Transcriptional Regulator BSA41_00130 ENOG4105D2H Uronic isomerase BSA41_00135 ENOG4105DUX Transporter BSA41_00145 ENOG4105CPU Monooxygenase BSA41_00150 ENOG4108XSB acetyltransferase, (GNAT) family BSA41_00155 ENOG4105EAB amino acid AbC transporter BSA41_00160 ENOG4108HW4 amino acid AbC transporter BSA41_00170 ENOG4105CH2 amidohydrolase BSA41_00175 ENOG4108PGP mmge prpd family protein BSA41_00180 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSA41_00185 ENOG4105BZU Histidine kinase BSA41_00195 ENOG4105CFH Aspartokinase BSA41_00205 ENOG4105R8C Transcriptional regulator BSA41_00215 ENOG4105YVS arsR family transcriptional regulator BSA41_00225 ENOG4108JPW Aminotransferase BSA41_00230 ENOG4107QTZ amino acid BSA41_00235 ENOG4105C26 Dehydrogenase BSA41_00240 ENOG4105DYS nad(p)h dehydrogenase (quinone) BSA41_00245 ENOG4105KTB nuclear export factor GLE1 BSA41_00250 ENOG4108T5E Copper resistance protein BSA41_00270 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BSA41_00275 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_00300 ENOG4105X3H Excalibur domain protein BSA41_00310 ENOG4105E7W lamb ycsf family protein BSA41_00315 ENOG4105C5A transporter BSA41_00320 ENOG4105CFM UPF0317 protein BSA41_00325 ENOG4105P4J Allophanate hydrolase, subunit 1 BSA41_00335 ENOG4107258 Transcriptional regulator BSA41_00340 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BSA41_00345 ENOG4105XJB lipolytic protein G-D-S-L family BSA41_00355 ENOG4105ETD TRANSCRIPTIONal BSA41_00360 ENOG4105HMZ Methyltransferase BSA41_00365 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BSA41_00370 ENOG410606W general stress protein BSA41_00395 ENOG4105VCH membrane BSA41_00400 ENOG4105DRR Transcriptional regulator, GntR family BSA41_00405 ENOG4106AXJ AraC family transcriptional regulator BSA41_00410 ENOG410631K Membrane BSA41_00415 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BSA41_00420 ENOG4105C9U ATP-dependent DNA helicase RecQ BSA41_00435 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BSA41_00440 ENOG4107R8N Glycosyl transferase, family 2 BSA41_00450 ENOG4105C0X amino acid BSA41_00485 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BSA41_00490 ENOG4107BMA Transglycosylase associated protein BSA41_00495 ENOG4105EU9 BSA41_00500 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BSA41_00505 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BSA41_00510 ENOG4108MRH transcriptional regulatory protein BSA41_00515 ENOG4107QJT sodium dicarboxylate symporter BSA41_00520 ENOG4106F5Q Membrane BSA41_00530 ENOG4105CJ1 ABC, transporter BSA41_00545 ENOG4105SZ6 Thioredoxin BSA41_00550 ENOG4105CPF Cell wall formation (By similarity) BSA41_00555 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BSA41_00570 ENOG4105C1J atp-dependent rna helicase BSA41_00575 ENOG410905X membrane-flanked domain protein BSA41_00580 ENOG4105CKV Membrane BSA41_00595 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BSA41_00600 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BSA41_00610 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BSA41_00615 ENOG4107MMM Anti-sigma-factor antagonist BSA41_00620 ENOG4105FUA antagonist BSA41_00625 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BSA41_00630 ENOG4107SGM protein serine threonine phosphatase BSA41_00635 ENOG4105WN5 stage II sporulation protein BSA41_00640 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BSA41_00650 ENOG41064BQ Phosphatase BSA41_00665 ENOG4107RUY (E1 component), alpha subunit BSA41_00675 ENOG4107QKR Dehydrogenase BSA41_00685 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BSA41_00725 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BSA41_00735 ENOG4105RHY Pfam:UPF0157 BSA41_00740 ENOG4105VEQ Cold shock protein BSA41_00745 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_00755 ENOG4105DQ4 alcohol dehydrogenase BSA41_00760 ENOG4105VUF Transcriptional regulator BSA41_00775 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSA41_00800 ENOG4105EMU Dehydrogenase BSA41_00810 ENOG4107RB3 L-asparaginase BSA41_00835 ENOG4105Z7P Acetyltransferase (GNAT) family BSA41_00850 ENOG4105VDT -acetyltransferase BSA41_00855 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BSA41_00865 ENOG4105ST3 Transcriptional regulator BSA41_00870 ENOG4105NAE bifunctional deaminase-reductase domain protein BSA41_00875 ENOG41090MY MarR family Transcriptional regulator BSA41_00880 ENOG4108TVJ Nitroreductase BSA41_00890 ENOG4108JCI Transcriptional regulator BSA41_00895 ENOG4108VP3 Lysine exporter protein (LysE YggA) BSA41_00920 ENOG4108UMN azlc family BSA41_00975 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BSA41_00980 ENOG4105K8N protein family UPF0079, ATPase BSA41_00985 ENOG41072GX Peptidase M22 Glycoprotease BSA41_00990 ENOG410801F ribosomal-protein-alanine acetyltransferase BSA41_00995 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BSA41_01000 ENOG4105C5H ABC transporter BSA41_01005 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BSA41_01010 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BSA41_01015 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BSA41_01020 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BSA41_01035 ENOG4108TYN CAAX amino terminal protease family protein BSA41_01040 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BSA41_01045 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BSA41_01050 ENOG4108U05 Transcriptional regulator BSA41_01055 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BSA41_01105 ENOG4107STQ Multicopper oxidase BSA41_01110 ENOG4105C85 amino acid BSA41_01120 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BSA41_01135 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BSA41_01170 ENOG4108UIN ybak prolyl-trna synthetase associated region BSA41_01180 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BSA41_01190 ENOG4108DMH HTH_ARAC BSA41_01200 ENOG4105KNA -acetyltransferase BSA41_01210 ENOG4105JVQ RNA Polymerase BSA41_01220 ENOG4108RWP Major Facilitator Superfamily protein BSA41_01225 ENOG4105GZI Transcriptional regulator BSA41_01230 ENOG4105C7N Xanthine uracil vitamin C permease BSA41_01250 ENOG4108U5N UPF0316 protein BSA41_01260 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BSA41_01265 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BSA41_01270 ENOG4105C83 adenylosuccinate lyase BSA41_01275 ENOG4105C8V SAICAR synthetase BSA41_01280 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BSA41_01290 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BSA41_01300 ENOG4105CXB phosphoribosylaminoimidazole synthetase BSA41_01305 ENOG4108V3E phosphoribosylglycinamide formyltransferase BSA41_01310 ENOG4105DC1 bifunctional purine biosynthesis protein purh BSA41_01315 ENOG4105C12 Phosphoribosylglycinamide synthetase BSA41_01335 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSA41_01350 ENOG4107S4Y M20 DapE family protein YgeY BSA41_01365 ENOG4105KGF protein, YerC YecD BSA41_01370 ENOG4105CBC glutamate synthase BSA41_01385 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BSA41_01390 ENOG4105C4R Atp-dependent dna helicase BSA41_01395 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BSA41_01405 ENOG4105CRN Aminoglycoside phosphotransferase BSA41_01410 ENOG4105KT7 mgtC SapB transporter BSA41_01415 ENOG4105CK7 Sodium proline symporter BSA41_01420 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BSA41_01425 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BSA41_01430 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BSA41_01435 ENOG4108IG5 Transcriptional regulator BSA41_01445 ENOG4105DU0 nucleoside hydrolase BSA41_01450 ENOG4105CBD Diacylglycerol kinase BSA41_01455 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BSA41_01470 ENOG4108Q3X Transcriptional regulator BSA41_01475 ENOG4105CI1 PTS System BSA41_01480 ENOG4105F8D glycoside hydrolase family 4 BSA41_01490 ENOG41062ES Transcriptional regulator BSA41_01495 ENOG4105C3M thioredoxin reductase BSA41_01510 ENOG4105F8D glycoside hydrolase family 4 BSA41_01515 ENOG4105HX0 Transcriptional regulator BSA41_01530 ENOG4105DUM transcriptional regulator, lysR family BSA41_01540 ENOG4108R1P BSA41_01545 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BSA41_01555 ENOG41090R9 glycosyltransferase BSA41_01560 ENOG4107R51 Glycosyl transferase, family 2 BSA41_01565 ENOG41090R9 glycosyltransferase BSA41_01570 ENOG4105EU0 Major facilitator Superfamily BSA41_01575 ENOG4107RVG penicillin-binding protein BSA41_01580 ENOG4105C8P )-transporter BSA41_01610 ENOG4105CUB amino acid BSA41_01615 ENOG4107TVC Glycosyl transferase, family 2 BSA41_01620 ENOG4105C5H ABC transporter BSA41_01625 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) BSA41_01630 ENOG4107SWG transcriptional regulator MERR family BSA41_01635 ENOG4105DXB Major Facilitator superfamily BSA41_01640 ENOG4105C5H ABC transporter BSA41_01645 ENOG4105FDU atp-dependent rna helicase BSA41_01650 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BSA41_01680 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BSA41_01685 ENOG4105E6M Sulphatase-modifying factor protein BSA41_01695 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BSA41_01710 ENOG4108MRH transcriptional regulatory protein BSA41_01730 ENOG4105PY6 Phenolic acid decarboxylase BSA41_01735 ENOG4105U3E Transcriptional regulator BSA41_01745 ENOG41084AG Acylphosphatase BSA41_01750 ENOG4108RPX mosc domain containing protein BSA41_01755 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BSA41_01765 ENOG4105NX3 Membrane BSA41_01785 ENOG4105DY8 decarboxylase BSA41_01790 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_01800 ENOG4105C5Y PTS System BSA41_01805 ENOG4105CG3 alpha amylase, catalytic region BSA41_01810 ENOG4107414 GntR family transcriptional regulator BSA41_01820 ENOG4105CGH 5'-nucleotidase BSA41_01825 ENOG4107RKG DJ-1/PfpI family BSA41_01835 ENOG4105BZG amino acid carrier protein BSA41_01840 ENOG4105KJF protein tyrosine phosphatase BSA41_01850 ENOG4107U9T Pfam:Ribonuclease_BN BSA41_01855 ENOG4108Z9I -acetyltransferase BSA41_01860 ENOG4108ISG Major Facilitator BSA41_01870 ENOG4105UPD Calcium Proton BSA41_01885 ENOG4105CDY transcriptional regulatory protein BSA41_01895 ENOG4105D8X mechanosensitive ion channel BSA41_01920 ENOG4105D7N magnesium and cobalt transport protein CorA BSA41_01935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BSA41_01965 ENOG4105C22 threonyL-tRNA synthetase BSA41_01990 ENOG410839T multidrug resistance protein BSA41_02010 ENOG4107TDE lipolytic protein G-D-S-L family BSA41_02020 ENOG4105FTV AraC Family Transcriptional Regulator BSA41_02025 ENOG4108V5C ABC transporter BSA41_02030 ENOG4105BZ1 (ABC) transporter BSA41_02035 ENOG4105KK4 UPF0060 membrane protein BSA41_02040 ENOG4105K6V RNA polymerase BSA41_02060 ENOG4108YYS metal-dependent hydrolase (By similarity) BSA41_02070 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BSA41_02085 ENOG410834F Transcriptional regulator BSA41_02110 ENOG4107Y03 Nitroreductase BSA41_02120 ENOG4105ECP epimerase BSA41_02125 ENOG4105KC9 Modulates RecA activity (By similarity) BSA41_02145 ENOG4105CKK Glycosyl transferase, family 2 BSA41_02150 ENOG4105EJV Membrane BSA41_02160 ENOG4105F0F Oxalate decarboxylase BSA41_02165 ENOG4106DF4 Sigma-70, region 4 BSA41_02175 ENOG41067AE Membrane-bound metal-dependent hydrolase BSA41_02180 ENOG4105CEN a g-specific adenine glycosylase BSA41_02185 ENOG4106BXE BSA41_02190 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BSA41_02205 ENOG4105EVI UPF0374 protein BSA41_02210 ENOG4105BZ1 (ABC) transporter BSA41_02215 ENOG4105C3U ABC transporter BSA41_02220 ENOG4108JQ7 (ABC) transporter BSA41_02225 ENOG4105DEF Extracellular solute-binding protein, family 5 BSA41_02230 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSA41_02235 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSA41_02240 ENOG4107NBY Membrane BSA41_02245 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BSA41_02250 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSA41_02255 ENOG4105G5W regulator Fur family BSA41_02405 ENOG4105E0M Sulfatase BSA41_02425 ENOG4105E2Y ABC, transporter BSA41_02440 ENOG4105CJ1 ABC, transporter BSA41_02475 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BSA41_02485 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BSA41_02490 ENOG4105CYN Serine protein kinase BSA41_02495 ENOG4106AKX UPF0229 protein BSA41_02500 ENOG4105CW7 secretion protein, HlyD family BSA41_02505 ENOG4105C0R drug resistance transporter emrb qaca subfamily BSA41_02510 ENOG4105CS1 NAD(P)H quinone oxidoreductase BSA41_02520 ENOG4105VEQ Cold shock protein BSA41_02525 ENOG4105BZU Histidine kinase BSA41_02555 ENOG4105BZU Histidine kinase BSA41_02570 ENOG4108YBP pseudouridine synthase BSA41_02580 ENOG4107YBY Hydrolase BSA41_02585 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BSA41_02600 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BSA41_02605 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BSA41_02610 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BSA41_02620 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BSA41_02625 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BSA41_02635 ENOG4105BZU Histidine kinase BSA41_02640 ENOG4105WH1 Two component transcriptional regulator luxr family BSA41_02660 ENOG4105CH6 catalase BSA41_02665 ENOG4105KPV Transcriptional regulator BSA41_02670 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BSA41_02675 ENOG4105ED1 spovr family BSA41_02680 ENOG4105G6Z alkaline phosphatase BSA41_02690 ENOG4105CUB amino acid BSA41_02700 ENOG4105J37 BSA41_02705 ENOG4108AEY RNA polymerase sigma factor BSA41_02710 ENOG4105F6E Acyl-transferase BSA41_02715 ENOG4105C37 (CBS) domain BSA41_02725 ENOG4105C37 (CBS) domain BSA41_02740 ENOG4105WMR Protein CrcB homolog BSA41_02745 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BSA41_02750 ENOG4105D64 Mechanosensitive ion channel BSA41_02755 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BSA41_02760 ENOG4107VMI polysaccharide deacetylase BSA41_02765 ENOG4105F0I Aminotransferase BSA41_02775 ENOG4105BZ1 (ABC) transporter BSA41_02780 ENOG4105BZ1 (ABC) transporter BSA41_02810 ENOG410839P BSA41_02820 ENOG4108UH6 UPF0754 membrane protein BSA41_02825 ENOG4105WZB UPF0342 protein BSA41_02835 ENOG4105D4P Coproporphyrinogen iii oxidase BSA41_02845 ENOG4107S91 Sodium hydrogen exchanger BSA41_02850 ENOG4105NCW Trka-c domain protein BSA41_02860 ENOG4105CGU Enoyl-CoA hydratase BSA41_02870 ENOG4107VRP DNA repair exonuclease BSA41_02875 ENOG4106D4I domain protein BSA41_02890 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BSA41_02925 ENOG4105NBU tryptophan transport protein BSA41_02930 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BSA41_02935 ENOG4105K59 histidine triad (HIT) protein BSA41_02965 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BSA41_02970 ENOG4105BZ4 penicillin-binding protein BSA41_02975 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BSA41_02980 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BSA41_02985 ENOG4105C1Q protoporphyrinogen oxidase BSA41_02995 ENOG4105ECB domain protein BSA41_03000 ENOG4105DER m42 family BSA41_03010 ENOG4108RQ5 Beta-lactamase domain-containing protein BSA41_03015 ENOG4105DF9 Lipoate-protein, ligase BSA41_03020 ENOG4105CEY Amp-dependent synthetase and ligase BSA41_03030 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BSA41_03040 ENOG4107TB6 phosphoglycerate mutase BSA41_03045 ENOG4106YBV Methyl-accepting chemotaxis BSA41_03065 ENOG4105XVF Competence transcription factor BSA41_03070 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSA41_03075 ENOG410635T phage-like element pbsx protein BSA41_03120 ENOG4108NF7 phage-type endonuclease BSA41_03125 ENOG4108PNI recT protein BSA41_03310 ENOG4108FKH Transglycosylase SLT domain BSA41_03415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSA41_03420 ENOG4105E5M Multidrug resistance protein D BSA41_03425 ENOG41067XF inhibitor BSA41_03430 ENOG4108KGH TRANSCRIPTIONal BSA41_03435 ENOG41060YP BSA41_03450 ENOG4108KK1 membrane protein AbrB duplication BSA41_03455 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BSA41_03460 ENOG41068WC Domain of unknown function (DUF955) BSA41_03465 ENOG4108IMY Transcriptional regulator BSA41_03490 ENOG4108RYM conjugative transposon protein BSA41_03500 ENOG4106BHR ftsk SpoIIIE family protein BSA41_03505 ENOG4106128 DNA-binding helix-turn-helix protein BSA41_03600 ENOG4105K4H Nlp p60 protein BSA41_03620 ENOG4105D0M Protease HtpX homolog BSA41_03640 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BSA41_03650 ENOG4105EYH Exonuclease BSA41_03700 ENOG4105ERH Fumarylacetoacetate hydrolase BSA41_03705 ENOG4106BKT UPF0344 protein BSA41_03715 ENOG4105CAQ asparagine synthetase BSA41_03735 ENOG4105UQX Mate efflux family protein BSA41_03740 ENOG4106HBX Transcriptional Regulator AraC Family BSA41_03770 ENOG4105DY8 decarboxylase BSA41_03815 ENOG4108VPT UPF0234 protein BSA41_03820 ENOG4105QNR S1 RNA binding domain protein BSA41_03825 ENOG4105DIH basic membrane BSA41_03830 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_03835 ENOG4105EPR degv family BSA41_03840 ENOG4107AYK membrAne BSA41_03850 ENOG41073B9 BSA41_03860 ENOG4108KP7 hydrolase BSA41_03865 ENOG4108MXZ Esterase BSA41_03870 ENOG4105VG1 fes assembly suf system protein BSA41_03875 ENOG4105IQ5 FAD linked oxidase domain protein BSA41_03885 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BSA41_03895 ENOG4105CAS nag kinase BSA41_03900 ENOG4105C8Y Acetylornithine aminotransferase BSA41_03905 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BSA41_03915 ENOG4105DBV ornithine carbamoyltransferase BSA41_03945 ENOG4107RMD Basic membrane lipoprotein BSA41_03960 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BSA41_03965 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BSA41_03975 ENOG4105C3U ABC transporter BSA41_03980 ENOG4108JQ7 (ABC) transporter BSA41_03995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSA41_04015 ENOG4105C31 Tryptophanyl-tRNA synthetase BSA41_04020 ENOG4108J59 Extracellular solute-binding protein, family 5 BSA41_04025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSA41_04030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSA41_04040 ENOG4108JQ7 (ABC) transporter BSA41_04055 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BSA41_04060 ENOG4108ZCF integral membrane protein BSA41_04065 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BSA41_04070 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BSA41_04080 ENOG4105DPN Oligoendopeptidase f BSA41_04085 ENOG4105T58 Dithiol-disulfide isomerase BSA41_04090 ENOG4108Z18 K06886 hemoglobin BSA41_04095 ENOG4105E4C Lytic transglycosylase catalytic BSA41_04100 ENOG4105MIX Adenylate cyclase BSA41_04105 ENOG4106EFP UPF0738 protein BSA41_04115 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BSA41_04120 ENOG4105EMS pseudouridine synthase BSA41_04125 ENOG4107S1Q Phosphatase BSA41_04135 ENOG4105ETU transcriptional activator (TenA BSA41_04140 ENOG4108VEU Thiamine monophosphate synthase BSA41_04155 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BSA41_04160 ENOG4105D06 uba thif-type nad fad binding protein BSA41_04165 ENOG4105DWF phosphomethylpyrimidine kinase BSA41_04170 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BSA41_04175 ENOG4107A88 BSA41_04225 ENOG4105ENA helicase BSA41_04250 ENOG4105C28 cystathionine BSA41_04255 ENOG4105C28 cystathionine BSA41_04310 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BSA41_04360 ENOG4107V2S Transcriptional regulator BSA41_04365 ENOG4105DJ2 Major Facilitator Superfamily BSA41_04400 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BSA41_04410 ENOG4105I03 Flagellin BSA41_04415 ENOG4105I03 Flagellin BSA41_04430 ENOG4105K7W phage-related replication protein BSA41_04435 ENOG410635T phage-like element pbsx protein BSA41_04440 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BSA41_04455 ENOG4105CJ3 phosphate transporter BSA41_04460 ENOG4107GRR phosphate transport regulator BSA41_04470 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BSA41_04475 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BSA41_04480 ENOG4108I5D sulfate abc transporter BSA41_04485 ENOG4105ECW sulfate abc transporter BSA41_04490 ENOG4108IJ6 ABC transporter BSA41_04500 ENOG4105DT3 PTS system, galactitol-specific IIc component BSA41_04515 ENOG4105CPQ Dehydrogenase BSA41_04520 ENOG4107RUY (E1 component), alpha subunit BSA41_04525 ENOG4105CPP Dehydrogenase, E1 component BSA41_04530 ENOG4105C7S Dehydrogenase BSA41_04540 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BSA41_04545 ENOG4105CHR reductase BSA41_04550 ENOG4107RHR regulatoR BSA41_04560 ENOG4107R7I amino acid BSA41_04570 ENOG4105C0H protease BSA41_04580 ENOG4108ME1 Peptidase M55 D-aminopeptidase BSA41_04585 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSA41_04590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSA41_04595 ENOG4105C3U ABC transporter BSA41_04605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BSA41_04610 ENOG4105DTQ mandelate racemase muconate lactonizing BSA41_04615 ENOG4107SN7 NLP P60 protein BSA41_04620 ENOG4108JQ7 (ABC) transporter BSA41_04625 ENOG4107TUM Amidinotransferase BSA41_04630 ENOG4108S4H thioesterase Superfamily protein BSA41_04635 ENOG4105K7K Transcriptional regulator BSA41_04650 ENOG4108428 Inherit from COG: -acetyltransferase BSA41_04655 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BSA41_04665 ENOG410839T multidrug resistance protein BSA41_04670 ENOG41080TC multidrug resistance protein BSA41_04680 ENOG4105CIY formyltetrahydrofolate deformylase BSA41_04685 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BSA41_04690 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BSA41_04710 ENOG4105K56 Transcriptional regulator BSA41_04715 ENOG4108ZHJ Organic hydroperoxide resistance protein BSA41_04720 ENOG4107Y2X deaminase BSA41_04725 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BSA41_04730 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_04745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSA41_04750 ENOG41062D9 Histidine kinase BSA41_04760 ENOG4106849 propeptide, pepSY amd peptidase M4 BSA41_04765 ENOG4105CJW magnesium transporter BSA41_04775 ENOG4105V75 Transcriptional regulator BSA41_04790 ENOG4105BZU Histidine kinase BSA41_04795 ENOG4107T5V SNARE associated Golgi BSA41_04800 ENOG4107TS3 membrane protein, TerC BSA41_04805 ENOG4108WZW RNA polymerase sigma BSA41_04815 ENOG410681C small acid-soluble spore protein BSA41_04825 ENOG4105D0M Protease HtpX homolog BSA41_04835 ENOG410900G Protein of unknown function (DUF421) BSA41_04840 ENOG4108TGC Acyltransferase BSA41_04845 ENOG4105BZU Histidine kinase BSA41_04850 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BSA41_04855 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BSA41_04860 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BSA41_04870 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BSA41_04875 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BSA41_04880 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BSA41_04885 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BSA41_04895 ENOG4105BZU Histidine kinase BSA41_04900 ENOG41090MY MarR family Transcriptional regulator BSA41_04905 ENOG4105ER2 Ompa motb domain protein BSA41_04910 ENOG4105E14 MotA TolQ exbB proton channel BSA41_04920 ENOG4108K88 Membrane BSA41_04925 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BSA41_04930 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BSA41_04935 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BSA41_04940 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BSA41_04965 ENOG4105F0V Cell wall hydrolase BSA41_04980 ENOG4105C59 p-type ATPase BSA41_04985 ENOG4105DC7 peptidase M24 BSA41_04995 ENOG4105CID antiterminator BSA41_05005 ENOG4105KRI phosphocarrier protein (HPr BSA41_05010 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BSA41_05020 ENOG4105F6S Spore photoproduct lyase BSA41_05025 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BSA41_05030 ENOG4105CHR reductase BSA41_05035 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BSA41_05040 ENOG4105K4I Scp-like extracellular BSA41_05050 ENOG4105BZU Histidine kinase BSA41_05055 ENOG4105CHM Aminotransferase BSA41_05065 ENOG41085PJ rdd domain containing protein BSA41_05075 ENOG4107R88 Chemotaxis protein (CheV) BSA41_05080 ENOG4105UIN BSA41_05085 ENOG4108MCI Transcriptional regulator, ARAC family BSA41_05090 ENOG4108UZ3 Transporter BSA41_05105 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BSA41_05115 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BSA41_05120 ENOG4105EPM Diguanylate phosphodiesterase BSA41_05125 ENOG4105WEF catalase BSA41_05130 ENOG4107IN1 Protein of unknown function (DUF1797) BSA41_05135 ENOG4108XRC Protein of unknown function (DUF458) BSA41_05165 ENOG4105NQC Flavodoxin BSA41_05170 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BSA41_05180 ENOG4106AUC UPF0180 protein BSA41_05185 ENOG4105D8X mechanosensitive ion channel BSA41_05190 ENOG4105D3R alkyl hydroperoxide reductase BSA41_05195 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSA41_05210 ENOG41080QG Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BSA41_05215 ENOG4105D06 uba thif-type nad fad binding protein BSA41_05220 ENOG4105CVM Molybdenum cofactor synthesis domain protein BSA41_05225 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BSA41_05230 ENOG4108ZAF Molybdopterin BSA41_05235 ENOG41067WU Molybdopterin converting factor (Subunit 1) BSA41_05250 ENOG4107X8C Efflux transporter RND family MFP subunit BSA41_05255 ENOG4105C19 ABC transporter BSA41_05260 ENOG4107RBB ABC transporter, permease BSA41_05265 ENOG4105E98 transcriptional regulator DeoR family BSA41_05270 ENOG4105DE4 1-phosphofructokinase BSA41_05275 ENOG4105DM4 PTS System BSA41_05290 ENOG4105C5H ABC transporter BSA41_05310 ENOG4105BZU Histidine kinase BSA41_05320 ENOG4107ZYR domain protein BSA41_05325 ENOG4105CPN adenine deaminase BSA41_05330 ENOG4105CN5 Metallo-Beta-Lactamase BSA41_05340 ENOG4108X4Q Hydrolase BSA41_05345 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BSA41_05365 ENOG4105CPP Dehydrogenase, E1 component BSA41_05370 ENOG4105C7S Dehydrogenase BSA41_05375 ENOG4107QN2 dihydrolipoyl dehydrogenase BSA41_05390 ENOG4105CXN decarboxylase BSA41_05400 ENOG4108WQ8 UPF0637 protein BSA41_05410 ENOG4105ECY inositol monophosphatase BSA41_05425 ENOG4105CI3 gtp-binding protein typa BSA41_05430 ENOG4105QA2 BSA41_05445 ENOG4108IAB Phoh family BSA41_05455 ENOG4105CSV Glutaminase BSA41_05465 ENOG4105CNI cell division protein FtsW BSA41_05470 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BSA41_05475 ENOG4105CVP deoxyribo-dipyrimidine photolyase BSA41_05485 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BSA41_05495 ENOG4105BZ9 Cytochrome C oxidase, subunit I BSA41_05500 ENOG4105CCU oxidase (Subunit III) BSA41_05505 ENOG41064X9 cytochrome C oxidase subunit IV BSA41_05520 ENOG41080XQ Signal transduction protein with cbs domains BSA41_05525 ENOG4106UY4 Inherit from COG: Scp-like extracellular BSA41_05550 ENOG4105WUC UPF0298 protein BSA41_05555 ENOG4106H78 methyltransferase BSA41_05560 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BSA41_05565 ENOG4105H20 Sporulation integral membrane protein YlbJ BSA41_05570 ENOG4105D78 K07001 NTE family protein BSA41_05575 ENOG41063PX domain protein BSA41_05580 ENOG4105CDE UPF0348 protein BSA41_05585 ENOG4105KNH Nucleic acid-binding protein BSA41_05590 ENOG41067VY 50S ribosomal protein L32 BSA41_05615 ENOG4108V6E Cell division protein mraZ BSA41_05620 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BSA41_05630 ENOG4105CJN penicillin-binding protein BSA41_05635 ENOG4105CJN penicillin-binding protein BSA41_05640 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BSA41_05645 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BSA41_05650 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BSA41_05655 ENOG4105CNI cell division protein FtsW BSA41_05660 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BSA41_05665 ENOG4105D4A Cell wall formation (By similarity) BSA41_05670 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BSA41_05675 ENOG4108R2U division initiation protein BSA41_05685 ENOG4105K67 small basic protein BSA41_05690 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BSA41_05695 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BSA41_05705 ENOG4105FFI sigma-e processing peptidase spoiiga BSA41_05710 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSA41_05720 ENOG4105DKT Transcriptional regulator BSA41_05735 ENOG410787A Pts system, glucitol sorbitol-specific BSA41_05740 ENOG4105DZY Pts system, glucitol sorbitol-specific BSA41_05745 ENOG4105VI0 Pts system, glucitol sorbitol-specific BSA41_05750 ENOG4105DKW ABC transporter BSA41_05755 ENOG4105WR5 sporulation protein, YlmC YmxH family BSA41_05760 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BSA41_05765 ENOG4105DFA alanine racemase domain protein BSA41_05770 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BSA41_05775 ENOG41067XK integral membrane protein BSA41_05780 ENOG4105DBK s4 domain protein BSA41_05790 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BSA41_05800 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BSA41_05805 ENOG4105C34 Pseudouridine synthase BSA41_05810 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BSA41_05820 ENOG4105CXT aspartate transcarbamylase BSA41_05825 ENOG4105CD3 dihydroorotase BSA41_05830 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BSA41_05835 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BSA41_05840 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BSA41_05845 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BSA41_05850 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BSA41_05855 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BSA41_05860 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BSA41_05870 ENOG4107RIQ Sulfate adenylate transferase BSA41_05875 ENOG4108WF4 Catalyzes the synthesis of activated sulfate (By similarity) BSA41_05880 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BSA41_05885 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BSA41_05890 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BSA41_05895 ENOG4105F23 Fibronectin-binding protein BSA41_05905 ENOG4105DSJ YicC domain protein BSA41_05910 ENOG4105KC4 UPF0296 protein BSA41_05915 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BSA41_05925 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BSA41_05930 ENOG4105C25 Primosomal protein n' BSA41_05935 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BSA41_05940 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BSA41_05945 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BSA41_05950 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BSA41_05955 ENOG4108ZF3 Phosphatase BSA41_05960 ENOG4105D9P serine threonine protein kinase BSA41_05965 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BSA41_05970 ENOG4105DJV ribulose-phosphate 3-epimerase BSA41_05975 ENOG4105FJ0 thiamine BSA41_05985 ENOG4105VB9 50S ribosomal protein l28 BSA41_05990 ENOG4108ZAA Alkaline-shock protein BSA41_05995 ENOG4105DP4 dak2 domain fusion protein ylov BSA41_06005 ENOG4105EJQ L-serine dehydratase BSA41_06010 ENOG4105CB5 ATP-dependent DNA helicase recG BSA41_06015 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BSA41_06020 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BSA41_06025 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSA41_06030 ENOG4105CHR reductase BSA41_06035 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BSA41_06040 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BSA41_06045 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BSA41_06050 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BSA41_06055 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BSA41_06065 ENOG4105K5M 30s ribosomal protein S16 BSA41_06070 ENOG4108BW8 UPF0109 protein BSA41_06080 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BSA41_06085 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BSA41_06090 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BSA41_06095 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BSA41_06105 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BSA41_06115 ENOG4105PGM cation diffusion facilitator family transporter BSA41_06120 ENOG4105KTU Transcriptional regulator, arsr family BSA41_06135 ENOG4105VM1 flagellar BSA41_06140 ENOG4105CMV Succinyl-CoA synthetase subunit beta BSA41_06145 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BSA41_06150 ENOG4105C79 DNA protecting protein DprA BSA41_06155 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BSA41_06160 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BSA41_06165 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSA41_06170 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BSA41_06175 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BSA41_06185 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BSA41_06190 ENOG4108ZC9 flagellar basal-body rod protein flgc BSA41_06195 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BSA41_06200 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BSA41_06205 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSA41_06220 ENOG4106YF4 Flagellar biosynthesis chaperone BSA41_06230 ENOG410696Y Flagellar hook-length control protein BSA41_06235 ENOG410822I Flagellar hook capping protein BSA41_06240 ENOG4108JQA flagellar BSA41_06245 ENOG41068WV flagellar FlbD family protein BSA41_06255 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BSA41_06260 ENOG4105DD5 Flagellar motor switch protein BSA41_06265 ENOG4107YTP response regulator receiver protein BSA41_06275 ENOG4105CN7 Flagellar biosynthetic protein FliP BSA41_06280 ENOG4105VS8 Flagellar biosynthetic protein fliq BSA41_06285 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BSA41_06290 ENOG4105D00 flagellar biosynthetic protein flhB BSA41_06295 ENOG4105D7B Flagellar biosynthesis protein flha BSA41_06300 ENOG4105FZW flagellar biosynthesis regulator FlhF BSA41_06310 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BSA41_06315 ENOG4105CBS Chea signal transduction histidine kinase BSA41_06320 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BSA41_06330 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BSA41_06335 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSA41_06345 ENOG4105CE9 30S ribosomal protein S2 BSA41_06350 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) BSA41_06360 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BSA41_06365 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BSA41_06370 ENOG4105KNE Phosphatidate cytidylyltransferase BSA41_06375 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BSA41_06380 ENOG4105DZP Membrane-associated zinc metalloprotease BSA41_06385 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BSA41_06390 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BSA41_06400 ENOG4105CYP glycoside hydrolase, family BSA41_06405 ENOG4105WJF BSA41_06420 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BSA41_06425 ENOG4105CHV Transcription elongation factor NusA BSA41_06430 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BSA41_06435 ENOG4105VHM ribosomal protein BSA41_06440 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BSA41_06445 ENOG4105W7A Protein of unknown function (DUF503) BSA41_06450 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BSA41_06455 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BSA41_06460 ENOG4105DTN riboflavin biosynthesis protein ribF BSA41_06465 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BSA41_06470 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BSA41_06480 ENOG4105C1V Peptidase, M16 BSA41_06495 ENOG4105E35 Dipicolinate synthase subunit A BSA41_06500 ENOG4108S0H Dipicolinic acid synthetase, b subunit BSA41_06505 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BSA41_06515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BSA41_06525 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BSA41_06535 ENOG4105CNU cell division protein FtsK BSA41_06540 ENOG4105FDP GntR family transcriptional regulator BSA41_06550 ENOG4105EYF MMPL domain protein BSA41_06570 ENOG4105EYF MMPL domain protein BSA41_06575 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BSA41_06580 ENOG4105XZV Protein of unknown function (DUF3243) BSA41_06595 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BSA41_06600 ENOG4105CEV competence damage-inducible protein BSA41_06605 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BSA41_06610 ENOG4108A04 Beta-lactamase BSA41_06615 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) BSA41_06620 ENOG4105D48 metallophosphoesterase BSA41_06625 ENOG4105MCT stage V sporulation protein S BSA41_06635 ENOG4105CPQ Dehydrogenase BSA41_06640 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BSA41_06650 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BSA41_06665 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BSA41_06670 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BSA41_06690 ENOG4108VJ1 Transcriptional regulator (CarD family BSA41_06695 ENOG4105K7W phage-related replication protein BSA41_06705 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_06710 ENOG4105K7W phage-related replication protein BSA41_06715 ENOG4108X3M OsmC Ohr family protein BSA41_06740 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BSA41_06760 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BSA41_06765 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSA41_06770 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BSA41_06775 ENOG4105U6W MutT NUDIX family protein BSA41_06785 ENOG4106F1P AAA ATPase, central domain protein BSA41_06790 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BSA41_06795 ENOG4105CXI aluminum resistance protein BSA41_06800 ENOG4105KV4 Transcriptional regulator BSA41_06805 ENOG4105C5F glutamine synthetase BSA41_06825 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_06920 ENOG4108ZMX Domain of unknown function (DU1801) BSA41_06925 ENOG410780I phosphoprotein phosphatase activity BSA41_06935 ENOG4105XPP Protein of unknown function (DUF1275) BSA41_06940 ENOG4105DQE DNA ligase BSA41_06945 ENOG4105FDF Could be involved in DNA repair (By similarity) BSA41_06950 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BSA41_06960 ENOG4108Z40 Transcriptional regulator BSA41_06965 ENOG4105ECR NmrA family BSA41_06990 ENOG41082JN Transcriptional regulator BSA41_06995 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BSA41_07000 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases BSA41_07005 ENOG4105WFK nuclease BSA41_07010 ENOG4106SCS STAS domain BSA41_07025 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BSA41_07035 ENOG4108SVB resolvase BSA41_07040 ENOG4105VPS UPF0291 protein BSA41_07045 ENOG4105CV1 Transketolase (EC 2.2.1.1) BSA41_07055 ENOG4105VXM UPF0154 protein BSA41_07065 ENOG4107QIV Cytochrome c biogenesis protein BSA41_07095 ENOG4108I0Z Aconitate hydratase BSA41_07100 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSA41_07120 ENOG4105MI2 BSA41_07125 ENOG4105W8X HesB YadR YfhF-family protein BSA41_07130 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BSA41_07135 ENOG4105K4P CoA-binding domain protein BSA41_07140 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSA41_07155 ENOG4106UW1 Major Facilitator superfamily BSA41_07160 ENOG4108QY0 Membrane BSA41_07165 ENOG4107ZYR domain protein BSA41_07170 ENOG4105CZN Potassium uptake protein BSA41_07180 ENOG4108UXE Protein tyrosine phosphatase BSA41_07185 ENOG4107R5R arsenical pump membrane protein BSA41_07190 ENOG41082YX Transcriptional regulator, arsr family BSA41_07195 ENOG41085FC arsR family transcriptional regulator BSA41_07205 ENOG4108Z7F N-acetyltransferase BSA41_07210 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BSA41_07215 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BSA41_07225 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BSA41_07230 ENOG4105F0H myo-inositol catabolism protein BSA41_07235 ENOG4105CIB oxidoreductase Domain protein BSA41_07240 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BSA41_07245 ENOG4105IE8 Alpha-ketoglutarate permease BSA41_07250 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) BSA41_07270 ENOG4105DH8 myo-inositol catabolism BSA41_07275 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BSA41_07285 ENOG4105D2N Aldolase BSA41_07295 ENOG4105C6T cysteine synthase BSA41_07300 ENOG4105KME endoribonuclease L-psp BSA41_07320 ENOG4106H6A BSA41_07325 ENOG4105N0V mono-oxygenase ydhR BSA41_07355 ENOG4108Z6Z Transcriptional regulator BSA41_07360 ENOG4105CS2 ec 3.2.1.21 BSA41_07365 ENOG4105C5Y PTS System BSA41_07385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSA41_07395 ENOG4107SYN Glycosyl hydrolases family 43 BSA41_07410 ENOG4105I1K ABC transporter BSA41_07415 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BSA41_07430 ENOG4105UP7 3-epimerase BSA41_07445 ENOG4106ETB IIa component BSA41_07490 ENOG4105D2N Aldolase BSA41_07495 ENOG4105DM4 PTS System BSA41_07500 ENOG4105DM4 PTS System BSA41_07505 ENOG4105DE4 1-phosphofructokinase BSA41_07510 ENOG4105HX0 Transcriptional regulator BSA41_07515 ENOG4107RZC phospholipase d BSA41_07535 ENOG4105C26 Dehydrogenase BSA41_07545 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BSA41_07555 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BSA41_07560 ENOG4107QX3 carboxylase BSA41_07565 ENOG4105E39 Enoyl-CoA hydratase BSA41_07570 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BSA41_07575 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BSA41_07580 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BSA41_07585 ENOG4105CEY Amp-dependent synthetase and ligase BSA41_07590 ENOG4105C1G acyl-Coa dehydrogenase BSA41_07595 ENOG4105F32 YngK protein BSA41_07620 ENOG4105CQB FAD linked oxidase domain protein BSA41_07625 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BSA41_07635 ENOG4108B31 Spore germination protein BSA41_07655 ENOG4107T5V SNARE associated Golgi BSA41_07660 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BSA41_07670 ENOG4105DEN Luciferase family BSA41_07685 ENOG4107QJQ Mate efflux family protein BSA41_07690 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BSA41_07695 ENOG4105NBR Pectinesterase BSA41_07700 ENOG4105H67 Protein of unknown function (DUF421) BSA41_07705 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BSA41_07710 ENOG4108IFG nitrite reductase, (NAD(P)H) BSA41_07730 ENOG4105BZ8 glutamate synthase BSA41_07735 ENOG4105CBC glutamate synthase BSA41_07740 ENOG4105C5Q Transcriptional regulator BSA41_07755 ENOG41090E6 transcriptional regulator MERR family BSA41_07760 ENOG4108UYN gCN5-related N-acetyltransferase BSA41_07765 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BSA41_07770 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BSA41_07785 ENOG4108J2R molybdopterin oxidoreductase BSA41_07795 ENOG4105CMG Carbohydrate kinase BSA41_07815 ENOG4105CT4 transporter BSA41_07820 ENOG4108Z7R Chaperone CsaA BSA41_07830 ENOG4105FVX BSA41_07850 ENOG4108W8B Beta-lactamase domain protein BSA41_07860 ENOG4105D29 Helix-turn-helix type 11 domain protein BSA41_07870 ENOG4105KTU Transcriptional regulator, arsr family BSA41_07875 ENOG4105CUB amino acid BSA41_07885 ENOG4105CR4 methylisocitrate lyase BSA41_07890 ENOG4105DXD 2-methylcitrate dehydratase BSA41_07900 ENOG4108SJC Membrane BSA41_07910 ENOG41069ER domain protein BSA41_07915 ENOG4105C9U ATP-dependent DNA helicase RecQ BSA41_07925 ENOG4105SCY DNAK suppressor BSA41_07945 ENOG4105C26 Dehydrogenase BSA41_07950 ENOG4105EWU Squalene--hopene cyclase BSA41_07955 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BSA41_07960 ENOG4105C09 Bile acid BSA41_07965 ENOG4105C7S Dehydrogenase BSA41_07970 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BSA41_07975 ENOG4107T89 von Willebrand factor, type A BSA41_07980 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BSA41_07990 ENOG4105K4H Nlp p60 protein BSA41_08000 ENOG4107QMU Mate efflux family protein BSA41_08020 ENOG4105FR1 rard protein BSA41_08050 ENOG4105E1V na solute symporter BSA41_08070 ENOG4108VXD carboxy-peptidase BSA41_08075 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BSA41_08080 ENOG4106Z5R BSA41_08085 ENOG410841Q phosphoesterase PA-phosphatase related protein BSA41_08095 ENOG4105VSD UPF0346 protein BSA41_08105 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BSA41_08110 ENOG4108JUB Transcriptional regulator BSA41_08140 ENOG4105C5E polysaccharide biosynthesis protein BSA41_08145 ENOG4105E0X reductase BSA41_08150 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BSA41_08175 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BSA41_08180 ENOG41090WU lipolytic protein G-D-S-L family BSA41_08185 ENOG4108KF3 Electron transport protein SCO1 SenC BSA41_08200 ENOG4105C7B Threonine dehydratase BSA41_08210 ENOG4108UT2 hemolysin iii BSA41_08220 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BSA41_08225 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BSA41_08240 ENOG4107YX5 Pfam:DUF548 BSA41_08245 ENOG4108Y6J UPF0403 protein BSA41_08250 ENOG4105C01 Dihydroxy-acid dehydratase BSA41_08265 ENOG4108V06 Glutathione peroxidase BSA41_08270 ENOG4105CKU formyltetrahydrofolate synthetase BSA41_08275 ENOG4105CVG Homoserine O-transsuccinylase BSA41_08280 ENOG4108QBV Monogalactosyldiacylglycerol synthase BSA41_08315 ENOG41081VK Ribonuclease BSA41_08335 ENOG410890F Dynamin family BSA41_08345 ENOG41065KQ synthase BSA41_08350 ENOG4107VMI polysaccharide deacetylase BSA41_08355 ENOG4105C2W permease BSA41_08365 ENOG4105CTD carboxy-peptidase BSA41_08370 ENOG4105DVT helicase BSA41_08380 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BSA41_08390 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BSA41_08395 ENOG4108UKS UPF0398 protein BSA41_08400 ENOG4107X2U Inherit from COG: Exonuclease-like protein BSA41_08405 ENOG4108I5C dEAD DEAH box helicase BSA41_08410 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSA41_08450 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BSA41_08455 ENOG4105BZ4 penicillin-binding protein BSA41_08465 ENOG4105CSM endonuclease III BSA41_08485 ENOG4105DVT helicase BSA41_08490 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BSA41_08495 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BSA41_08500 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BSA41_08510 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BSA41_08515 ENOG4105CPK Glycosyl transferase (Group 1 BSA41_08520 ENOG4105FJR Lmbe family BSA41_08525 ENOG4108Z5K methylglyoxal synthase BSA41_08530 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BSA41_08535 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BSA41_08540 ENOG4108JYZ YitT family BSA41_08560 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BSA41_08575 ENOG4108SXZ UPF0302 protein BSA41_08580 ENOG41068YB TPR repeat-containing protein BSA41_08585 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BSA41_08595 ENOG4105CIH Imidazole acetol-phosphate transaminase BSA41_08600 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BSA41_08605 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BSA41_08610 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BSA41_08615 ENOG4105DK0 Indole-3-glycerol phosphate synthase BSA41_08630 ENOG4105KHN chorismate mutase BSA41_08635 ENOG4105D49 3-dehydroquinate synthase BSA41_08640 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BSA41_08645 ENOG4105BZU Histidine kinase BSA41_08650 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BSA41_08655 ENOG4105EAH synthase BSA41_08660 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BSA41_08665 ENOG4105XXQ heptaprenyl diphosphate synthase component I BSA41_08675 ENOG4105EUJ GTP cyclohydrolase i BSA41_08680 ENOG4105K70 DNA-binding protein BSA41_08685 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BSA41_08700 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BSA41_08705 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BSA41_08710 ENOG41065D1 BSA41_08715 ENOG4105S2F BSA41_08730 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BSA41_08735 ENOG4105CAT Cytidine monophosphate kinase BSA41_08750 ENOG4105MSI germination protein ypeb BSA41_08760 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BSA41_08765 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BSA41_08780 ENOG4107RGJ metallophosphoesterase BSA41_08795 ENOG4105I7S Abortive infection protein BSA41_08800 ENOG4105C9U ATP-dependent DNA helicase RecQ BSA41_08805 ENOG4105T7X BSA41_08815 ENOG4108SAX Membrane BSA41_08820 ENOG4108JQ1 Dehydrogenase BSA41_08825 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BSA41_08840 ENOG4105BZU Histidine kinase BSA41_08845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSA41_08850 ENOG4105CRE cytochrome C BSA41_08855 ENOG4107TWT Cytochrome c biogenesis protein BSA41_08865 ENOG4105FE9 pseudouridine synthase BSA41_08875 ENOG4108JIC nucleoside recognition domain protein BSA41_08880 ENOG4105DZ1 carboxypeptidase BSA41_08890 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BSA41_08895 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BSA41_08910 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BSA41_08920 ENOG4108R6K riboflavin synthase, subunit alpha BSA41_08945 ENOG4107ZE5 PPIases accelerate the folding of proteins BSA41_08950 ENOG4105PTM secreted protein BSA41_08955 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BSA41_08965 ENOG4105G6R Stage v sporulation protein ae BSA41_08975 ENOG4105CZ3 stage V sporulation protein ad BSA41_08980 ENOG41090VF Stage v sporulation protein ac BSA41_08995 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSA41_09000 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BSA41_09005 ENOG41082AN stage II sporulation protein BSA41_09010 ENOG4105DZ1 carboxypeptidase BSA41_09015 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BSA41_09020 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BSA41_09025 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BSA41_09035 ENOG4105I3K Ferric uptake regulator, Fur family BSA41_09040 ENOG4105MZ9 stage II sporulation protein m BSA41_09055 ENOG4107YB6 acetyltransferase, (GNAT) family BSA41_09065 ENOG4108YZ4 nudix hydrolase BSA41_09070 ENOG4105CPC Aldo Keto reductase BSA41_09100 ENOG4106HZJ BSA41_09105 ENOG4105RHY Pfam:UPF0157 BSA41_09110 ENOG4108XET gCN5-related N-acetyltransferase BSA41_09120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BSA41_09130 ENOG4105E5W Transporter BSA41_09140 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase BSA41_09145 ENOG4108IXY short-chain dehydrogenase reductase BSA41_09150 ENOG41069FQ Metallo-beta-lactamase superfamily BSA41_09155 ENOG4105II7 pyrroline-5-carboxylate reductase BSA41_09170 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BSA41_09180 ENOG4105XT2 Transcriptional regulator BSA41_09185 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BSA41_09190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BSA41_09195 ENOG4108TZY GntR Family Transcriptional Regulator BSA41_09200 ENOG4105CS2 ec 3.2.1.21 BSA41_09205 ENOG4105CK1 PTS System BSA41_09210 ENOG4105VCP PTS System BSA41_09215 ENOG4105VZJ PTS System BSA41_09220 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BSA41_09225 ENOG4105CSC Glucose uptake protein BSA41_09230 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BSA41_09235 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BSA41_09250 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BSA41_09260 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BSA41_09265 ENOG4108HNZ carboxyl transferase BSA41_09270 ENOG4108ZVT methylmalonyl-coA epimerase BSA41_09275 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BSA41_09280 ENOG4108QEG Membrane BSA41_09285 ENOG4105CDA abc transporter atp-binding protein BSA41_09290 ENOG4105E5Q amino acid AbC transporter BSA41_09295 ENOG4108HW3 (ABC) transporter BSA41_09300 ENOG4108Y6J UPF0403 protein BSA41_09305 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BSA41_09315 ENOG4105C7S Dehydrogenase BSA41_09320 ENOG4105CPP Dehydrogenase, E1 component BSA41_09335 ENOG4105CKM Branched-chain carboxylic acid kinase BSA41_09340 ENOG4107RDP Dehydrogenase BSA41_09350 ENOG4108JUB Transcriptional regulator BSA41_09355 ENOG4106CCJ Protein of unknown function (DUF2627) BSA41_09360 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BSA41_09375 ENOG4107QQR Sporulation BSA41_09380 ENOG4105S1Z Stage IV sporulation protein B BSA41_09385 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BSA41_09390 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BSA41_09395 ENOG4105DX0 Hemolysin A BSA41_09400 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BSA41_09405 ENOG4105CTB Polyprenyl synthetase BSA41_09410 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BSA41_09415 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BSA41_09420 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BSA41_09425 ENOG4105M7K Involved in the transcription termination process (By similarity) BSA41_09430 ENOG4108ZSR alkaline shock protein BSA41_09435 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BSA41_09455 ENOG410644B Stage III sporulation protein af BSA41_09465 ENOG4105KQ4 Stage iii sporulation protein ad BSA41_09470 ENOG4108CQH stage III sporulation protein AC BSA41_09475 ENOG4105KR5 Stage iii sporulation protein BSA41_09480 ENOG4105CD2 stage iii sporulation protein aa BSA41_09490 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BSA41_09495 ENOG4105DC7 peptidase M24 BSA41_09500 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BSA41_09510 ENOG4105CBJ Metal-dependent enzyme BSA41_09525 ENOG4105KST dependent repressor BSA41_09530 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BSA41_09535 ENOG4105WZW rhodanese family BSA41_09540 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BSA41_09550 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BSA41_09555 ENOG4105C0D helicase BSA41_09575 ENOG4105VFR signal peptidase BSA41_09615 ENOG4106855 Competence protein BSA41_09650 ENOG4105C5X domain protein BSA41_09670 ENOG4105E0M Sulfatase BSA41_09685 ENOG4107ZXI Rhomboid family BSA41_09695 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BSA41_09700 ENOG4105WDJ 50S ribosomal protein L33 BSA41_09710 ENOG41068DG YceG-like family BSA41_09715 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BSA41_09720 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BSA41_09725 ENOG4105E2Z phosphate ABC transporter (Permease BSA41_09730 ENOG4105C8U phosphate abc transporter BSA41_09735 ENOG4105CVA phosphate BSA41_09740 ENOG4107RF6 penicillin-binding protein BSA41_09750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BSA41_09760 ENOG4105SXS Protein of unknown function (DUF456) BSA41_09770 ENOG4105D9U N-acetyltransferase BSA41_09775 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BSA41_09780 ENOG41063Y9 BSA41_09785 ENOG4108U5J '-nucleotidase BSA41_09790 ENOG41066F8 ROK family BSA41_09795 ENOG4105N80 Ferric uptake regulator, Fur family BSA41_09800 ENOG4105FAV ABC, transporter BSA41_09805 ENOG4105FDK ABC transporter BSA41_09810 ENOG4108JYZ YitT family BSA41_09815 ENOG41069ZM Protein of unknown function (DUF2624) BSA41_09820 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BSA41_09835 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BSA41_09840 ENOG4105EGD dinuclear metal center protein, YbgI family BSA41_09855 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSA41_09860 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BSA41_09865 ENOG4108UPT UPF0178 protein BSA41_09870 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BSA41_09880 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BSA41_09885 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BSA41_09890 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BSA41_09895 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BSA41_09900 ENOG4105KG3 cytidine deaminase BSA41_09905 ENOG4107YR5 Diacylglycerol kinase BSA41_09910 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BSA41_09915 ENOG4105CTJ Metal Dependent Phosphohydrolase BSA41_09920 ENOG4105C9A Phoh family BSA41_09925 ENOG4105EI1 sporulation protein yqfd BSA41_09930 ENOG41068P3 sporulation protein YqfC BSA41_09940 ENOG4105DI5 UPF0365 protein BSA41_09945 ENOG4105F7J membrane-bound serine protease BSA41_09950 ENOG4105KTH gatB Yqey BSA41_09965 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BSA41_09970 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BSA41_09975 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BSA41_09980 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BSA41_09990 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BSA41_09995 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BSA41_10000 ENOG4105CSA Coproporphyrinogen iii oxidase BSA41_10005 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BSA41_10015 ENOG4108ZRV stage ii sporulation protein p BSA41_10030 ENOG4105TQK DNA polymerase iii, delta' subunit BSA41_10035 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BSA41_10045 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BSA41_10055 ENOG4108D32 Methyltransferase BSA41_10065 ENOG4108WF2 Metal Dependent Phosphohydrolase BSA41_10070 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BSA41_10075 ENOG410812S Rna-binding protein BSA41_10080 ENOG4105E2X shikimate dehydrogenase BSA41_10085 ENOG4105CQW ribosome biogenesis GTPase YqeH BSA41_10090 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BSA41_10115 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSA41_10145 ENOG4108ZJ4 polysaccharide deacetylase BSA41_10180 ENOG4105CJ1 ABC, transporter BSA41_10195 ENOG4107QNK )-transporter BSA41_10200 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BSA41_10215 ENOG4105CMD Transcriptional regulator, GntR family BSA41_10235 ENOG41080HJ 6-phospho 3-hexuloisomerase BSA41_10240 ENOG4108VA3 3-hexulose-6-phosphate synthase BSA41_10245 ENOG4105KVH Transcriptional regulator BSA41_10270 ENOG4108HWY Beta-lactamase BSA41_10275 ENOG4105FDT acyl-CoA dehydrogenase BSA41_10295 ENOG4105E5Q amino acid AbC transporter BSA41_10300 ENOG4105WEF catalase BSA41_10315 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BSA41_10320 ENOG4108KYE ABC-2 type transporter BSA41_10325 ENOG41090VJ ABC-2 type transporter BSA41_10330 ENOG4105CJ1 ABC, transporter BSA41_10335 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BSA41_10345 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase BSA41_10350 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BSA41_10355 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BSA41_10360 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BSA41_10375 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BSA41_10380 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BSA41_10385 ENOG4105CHR reductase BSA41_10390 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BSA41_10400 ENOG4105E2A Dehydrogenase BSA41_10420 ENOG4105C28 cystathionine BSA41_10430 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BSA41_10435 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BSA41_10450 ENOG4107XRG penicillin-binding protein BSA41_10455 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BSA41_10460 ENOG4107S03 uridine kinase BSA41_10465 ENOG4105CFP Peptidase U32 BSA41_10470 ENOG4105XYU peptidase (U32 family) BSA41_10475 ENOG4108VQJ O-methyltransferase BSA41_10480 ENOG4105HHA aminodeoxychorismate lyase BSA41_10490 ENOG4107F3J Amp-dependent synthetase and ligase BSA41_10495 ENOG4107ZYJ bioY protein BSA41_10500 ENOG4105VPH UPF0473 protein BSA41_10505 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BSA41_10510 ENOG4105VBH UPF0297 protein BSA41_10520 ENOG4105C02 permease BSA41_10525 ENOG4105CDA abc transporter atp-binding protein BSA41_10530 ENOG4105CT1 (ABC) transporter BSA41_10535 ENOG4105EAD ABC transporter BSA41_10540 ENOG4105DRP amino acid AbC transporter BSA41_10545 ENOG41060CR BSA41_10555 ENOG4105C7H Helicase, RecD TraA family BSA41_10565 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BSA41_10570 ENOG4105C3J Cysteine desulfurase BSA41_10580 ENOG4105D1H recombination factor protein RarA BSA41_10585 ENOG4105CUZ uba thif-type nad fad binding protein BSA41_10595 ENOG4105C9M aspartyl-trna synthetase BSA41_10600 ENOG4105CUT histidyl-tRNA synthetase BSA41_10605 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSA41_10610 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BSA41_10615 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BSA41_10620 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BSA41_10625 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BSA41_10630 ENOG41067VP Protein of unknown function (DUF1049) BSA41_10635 ENOG4105NCW Trka-c domain protein BSA41_10640 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BSA41_10650 ENOG4105CKP Polysaccharide Biosynthesis Protein BSA41_10655 ENOG4108QG2 Membrane BSA41_10660 ENOG4105NAP BSA41_10665 ENOG4105VIE preprotein translocase, subunit YajC BSA41_10670 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BSA41_10675 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BSA41_10680 ENOG41061AI Protein of unknown function (DUF2905) BSA41_10685 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BSA41_10690 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BSA41_10710 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BSA41_10725 ENOG4106678 morphogenetic protein associated with SpoVID BSA41_10725 ENOG4106678 morphogenetic protein associated with SpoVID BSA41_10730 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BSA41_10735 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BSA41_10740 ENOG4108IYU L-aspartate oxidase BSA41_10755 ENOG4105CQC Prephenate dehydratase BSA41_10765 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BSA41_10775 ENOG4105K46 50S ribosomal protein l27 BSA41_10780 ENOG4105X36 (ribosomal) protein BSA41_10785 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BSA41_10800 ENOG4107QMS site-determining protein BSA41_10805 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BSA41_10810 ENOG4105YHC Rod shape-determining protein MreD BSA41_10815 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BSA41_10820 ENOG4105DFF Rod shape-determining protein mreb BSA41_10825 ENOG4105W5Q DNA repair protein (RadC BSA41_10830 ENOG4108Z03 MAF-like protein BSA41_10845 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BSA41_10850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BSA41_10860 ENOG4106AR7 Spore coat protein BSA41_10865 ENOG41068KH stage VI sporulation protein D BSA41_10870 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BSA41_10875 ENOG4105D52 delta-aminolevulinic acid dehydratase BSA41_10885 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BSA41_10895 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BSA41_10905 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BSA41_10910 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BSA41_10915 ENOG4108IUQ atp-dependent protease BSA41_10920 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BSA41_10925 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BSA41_10935 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BSA41_10940 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BSA41_10945 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BSA41_10950 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BSA41_10955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BSA41_10960 ENOG4108ZP8 Acetolactate synthase small subunit BSA41_10965 ENOG4105C7K acetolactate synthase BSA41_10970 ENOG4105CM2 brancheD-chain amino acid aminotransferase BSA41_10975 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BSA41_10985 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BSA41_10995 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BSA41_11000 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BSA41_11010 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BSA41_11035 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BSA41_11055 ENOG4105M59 Phosphodiesterase, mj0936 family BSA41_11060 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BSA41_11065 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BSA41_11070 ENOG4108XJQ germination protein BSA41_11075 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BSA41_11080 ENOG41067TZ transcriptional regulator, MarR family BSA41_11085 ENOG4105PFC Transcriptional regulator BSA41_11095 ENOG4108KAM Transcriptional regulator BSA41_11100 ENOG4105C7F AcnD-accessory protein PrpF BSA41_11105 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BSA41_11115 ENOG4105E33 succinate dehydrogenase BSA41_11125 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BSA41_11135 ENOG4105CFH Aspartokinase BSA41_11140 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BSA41_11145 ENOG4105K63 Thioredoxin BSA41_11150 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BSA41_11155 ENOG4105C10 Electron transfer flavoprotein BSA41_11160 ENOG4105BZJ Electron transfer flavoprotein BSA41_11165 ENOG41060WC Enoyl-CoA hydratase BSA41_11170 ENOG4107Z3H Transcriptional regulator, TetR family BSA41_11175 ENOG4105CEY Amp-dependent synthetase and ligase BSA41_11190 ENOG4105C98 muts2 protein BSA41_11195 ENOG4105DCG PHP domain protein BSA41_11205 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BSA41_11210 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BSA41_11215 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BSA41_11220 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BSA41_11225 ENOG4108RWN rrna methyltransferase BSA41_11230 ENOG41067MF small acid-soluble spore protein BSA41_11240 ENOG4105CN9 Peptidase m42 family protein BSA41_11250 ENOG410696E Membrane BSA41_11255 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BSA41_11260 ENOG4105VJV 50s ribosomal protein L35 BSA41_11265 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BSA41_11270 ENOG41067MG lrgb family BSA41_11280 ENOG4105DY9 regulatoR BSA41_11285 ENOG4108HRK Histidine kinase BSA41_11290 ENOG4105U0R haloacid dehalogenase-like hydrolase BSA41_11295 ENOG4107SDU Methyl-accepting chemotaxis BSA41_11300 ENOG4105C22 threonyL-tRNA synthetase BSA41_11305 ENOG4108TDW sporulation protein YtxC BSA41_11325 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BSA41_11335 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BSA41_11340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSA41_11345 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BSA41_11355 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BSA41_11360 ENOG4105C2M dna polymerase I BSA41_11365 ENOG4105BZU Histidine kinase BSA41_11370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSA41_11375 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BSA41_11380 ENOG4108HMX isocitrate dehydrogenase (NADP) BSA41_11385 ENOG4105BZN citrate synthase BSA41_11390 ENOG4107CWS Protein of unknown function (DUF441) BSA41_11395 ENOG4108REF Sporulation integral membrane protein ytvi BSA41_11400 ENOG4105FS0 cytoplasmic membrane protein BSA41_11405 ENOG4105CA9 Pyruvate kinase BSA41_11410 ENOG4105CTQ phosphohexokinase BSA41_11420 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BSA41_11425 ENOG4105C6K Malic enzyme BSA41_11430 ENOG4105C0B DNA polymerase III (alpha subunit) BSA41_11435 ENOG4105VV2 BSA41_11445 ENOG4106EVM BSA41_11450 ENOG4105SFS phosphoesterase RecJ domain protein BSA41_11465 ENOG4105E8R UPF0173 metal-dependent hydrolase BSA41_11480 ENOG4105CH7 arginosuccinase BSA41_11485 ENOG4105CDH Citrulline--aspartate ligase BSA41_11490 ENOG4105EPU Molybdenum cofactor synthesis domain protein BSA41_11495 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BSA41_11505 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BSA41_11510 ENOG4105KBJ sporulation protein ytfj BSA41_11520 ENOG4105VK3 rdd domain containing protein BSA41_11525 ENOG4105D07 Signal peptide peptidase, SppA BSA41_11530 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BSA41_11535 ENOG4105C1J atp-dependent rna helicase BSA41_11540 ENOG4105ECK Fatty Acid Desaturase BSA41_11545 ENOG4108ZGX Histidine kinase BSA41_11550 ENOG4108S01 response regulator BSA41_11555 ENOG4108V5C ABC transporter BSA41_11565 ENOG4105EWM Histidine kinase BSA41_11570 ENOG4105C19 ABC transporter BSA41_11580 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BSA41_11585 ENOG4108X0B nad(p)h dehydrogenase (quinone) BSA41_11595 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BSA41_11600 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BSA41_11610 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BSA41_11640 ENOG4105U5Y Transcriptional regulator BSA41_11650 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BSA41_11670 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BSA41_11675 ENOG4105KAC Antibiotic biosynthesis monooxygenase BSA41_11680 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BSA41_11690 ENOG4105F1V Acetoin utilization protein BSA41_11695 ENOG4105W87 Cbs domain BSA41_11700 ENOG4105DGU Histone deacetylase BSA41_11705 ENOG4105ETE Transcriptional regulator (LacI family BSA41_11710 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BSA41_11730 ENOG4105DFU Cell wall formation (By similarity) BSA41_11740 ENOG4108VDD TRNA binding domain protein BSA41_11745 ENOG4108NKM UPF0354 protein BSA41_11760 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BSA41_11775 ENOG4105C6K Malic enzyme BSA41_11780 ENOG4105C8F Beta-lactamase domain protein BSA41_11785 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BSA41_11795 ENOG4108V15 phosphotransferase enzyme family BSA41_11815 ENOG4107F58 2'-5' rna ligase BSA41_11820 ENOG4105C6T cysteine synthase BSA41_11825 ENOG4107XNU peptidase BSA41_11830 ENOG4107QSE Dipeptidase BSA41_11835 ENOG4105C7N Xanthine uracil vitamin C permease BSA41_11840 ENOG4105YW5 deoR family transcriptional regulator BSA41_11855 ENOG4105CBX hi0933 family BSA41_11865 ENOG4105C94 Transporter BSA41_11870 ENOG4106611 bacteriocin immunity BSA41_11880 ENOG41085GJ domain protein BSA41_11885 ENOG4105MU9 integral membrane protein BSA41_11890 ENOG4105DDC Oxidoreductase domain protein BSA41_11900 ENOG4105F5H Glycosyl Hydrolase Family 88 BSA41_11910 ENOG41075H3 AraC family transcriptional regulator BSA41_11915 ENOG4105KVH Transcriptional regulator BSA41_11920 ENOG4105F27 Major Facilitator BSA41_11925 ENOG4105CV8 reductase BSA41_11935 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component BSA41_11945 ENOG4105NTD Inherit from COG: Hydrolase BSA41_11950 ENOG4105C8T Leucyl-tRNA synthetase BSA41_11960 ENOG4105BZU Histidine kinase BSA41_11965 ENOG4106UBQ BSA41_11970 ENOG4107R34 abc transporter permease protein BSA41_11975 ENOG4105C19 ABC transporter BSA41_11985 ENOG4105DVE abc transporter atp-binding protein BSA41_11990 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BSA41_12005 ENOG4105N5T Radical SAM Protein BSA41_12020 ENOG4105E8V Alpha Beta Hydrolase Fold protein BSA41_12025 ENOG4108Z0R Transferase BSA41_12030 ENOG4105CAQ asparagine synthetase BSA41_12035 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BSA41_12055 ENOG4105EWK phytoene BSA41_12075 ENOG4105D2X ABC transporter substrate-binding protein BSA41_12085 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BSA41_12095 ENOG4106FN3 tellurium resistance protein BSA41_12120 ENOG4108RMU ferritin dps family protein BSA41_12135 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BSA41_12140 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BSA41_12145 ENOG4108V2W Carbonate dehydratase BSA41_12150 ENOG4105DSE periplasmic solute binding protein BSA41_12180 ENOG4105DTQ mandelate racemase muconate lactonizing BSA41_12190 ENOG4108IPT Naphthoate synthase BSA41_12195 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BSA41_12200 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BSA41_12205 ENOG4105E4F Isochorismate synthase BSA41_12210 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BSA41_12220 ENOG4108606 TspO/MBR family BSA41_12345 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BSA41_12355 ENOG4105VRR gCN5-related N-acetyltransferase BSA41_12360 ENOG4105DZ6 Band 7 protein BSA41_12370 ENOG4106DF1 BSA41_12375 ENOG4108JB8 alcohol dehydrogenase BSA41_12380 ENOG4105C26 Dehydrogenase BSA41_12385 ENOG4105TRT Transcriptional regulator BSA41_12415 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BSA41_12440 ENOG41068G1 BSA41_12470 ENOG410906S phage-like element pbsx protein xkdt BSA41_12475 ENOG41066EA baseplate J family protein BSA41_12480 ENOG4105MFU Protein of unknown function (DUF2634) BSA41_12490 ENOG4105X7F BSA41_12495 ENOG4108WZM domain protein BSA41_12500 ENOG4108FKH Transglycosylase SLT domain BSA41_12505 ENOG4105MTC XkdN-like protein BSA41_12510 ENOG4105FR7 XkdM protein, phage-like element PBSX BSA41_12515 ENOG4105PQS phage protein BSA41_12530 ENOG41060SN BSA41_12555 ENOG4108MDF Phage Portal Protein BSA41_12560 ENOG4105IG6 Phage terminase, large subunit BSA41_12580 ENOG4105QBX endodeoxyribonuclease RusA BSA41_12605 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BSA41_12615 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BSA41_12630 ENOG4105EE0 oxidoreductase BSA41_12635 ENOG4108Z0Z intracellular protease Pfpi family BSA41_12640 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_12645 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_12650 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_12655 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_12670 ENOG4105EA8 2-Nitropropane dioxygenase BSA41_12675 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BSA41_12680 ENOG4105C37 (CBS) domain BSA41_12695 ENOG4107PBV potassium channel BSA41_12710 ENOG4107QYV phosphohexose isomerase BSA41_12720 ENOG4107QW4 alcohol dehydrogenase BSA41_12725 ENOG4105WG9 Conserved Protein BSA41_12735 ENOG4105CHM Aminotransferase BSA41_12740 ENOG4108ZB6 transcriptional regulator AsnC family BSA41_12745 ENOG4108MUZ hydrolase BSA41_12755 ENOG4105C87 Aminotransferase class I and II BSA41_12760 ENOG4108HGU Histidine kinase BSA41_12765 ENOG4105Y38 Kinase-associated protein B BSA41_12780 ENOG4105BZ4 penicillin-binding protein BSA41_12785 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BSA41_12800 ENOG4108MRH transcriptional regulatory protein BSA41_12805 ENOG4105DIH basic membrane BSA41_12810 ENOG4108JQ9 ABC transporter BSA41_12815 ENOG4105UIB (ABC) transporter BSA41_12835 ENOG4105D65 subunit l BSA41_12840 ENOG4105HC0 Na H antiporter BSA41_12845 ENOG4108ZE9 Monovalent cation H antiporter subunit C BSA41_12850 ENOG4108JPZ Monovalent cation H antiporter subunit D BSA41_12855 ENOG4105SC1 monovalent cation H antiporter subunit E BSA41_12865 ENOG4105KJM monovalent cation h antiporter subunit g BSA41_12870 ENOG4105KA0 thioesterase Superfamily protein BSA41_12880 ENOG4105BZU Histidine kinase BSA41_12900 ENOG4105D58 Diguanylate phosphodiesterase BSA41_12905 ENOG4105DAP Nicotinate phosphoribosyltransferase BSA41_12930 ENOG4105C02 permease BSA41_12950 ENOG410904N short-chain dehydrogenase reductase BSA41_12985 ENOG4108K8K Transcriptional regulator BSA41_12990 ENOG4105DCF alanine dehydrogenase BSA41_13000 ENOG4108N23 SpoOM-related protein BSA41_13010 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BSA41_13020 ENOG41069ER domain protein BSA41_13030 ENOG4105CEP NADH dehydrogenase BSA41_13035 ENOG4105CAY ferredoxin--nadp reductase BSA41_13045 ENOG4107TXC Transcriptional regulator BSA41_13050 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BSA41_13055 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BSA41_13060 ENOG4105ZKE UPF0349 protein BSA41_13080 ENOG41083MR nifu domain-containing protein BSA41_13085 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BSA41_13095 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BSA41_13100 ENOG4105D6E homoserine dehydrogenase BSA41_13105 ENOG4105C5I Dehydrogenase BSA41_13115 ENOG4108W5N phosphatidylglycerophosphatase a BSA41_13120 ENOG4105D4U had-superfamily hydrolase, subfamily iia BSA41_13130 ENOG4105MMD transcriptional regulator BSA41_13135 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BSA41_13145 ENOG4105FAA peptidase M23 BSA41_13150 ENOG4108YTE sporulation protein YunB BSA41_13155 ENOG4105KZD Domain of unknown function (DUF1805) BSA41_13160 ENOG4107R8B 5'-nucleotidase BSA41_13165 ENOG4105I3N Conserved Protein BSA41_13170 ENOG4105G9B Transcriptional regulator BSA41_13175 ENOG4105F0F Oxalate decarboxylase BSA41_13190 ENOG4105C5R Aminotransferase BSA41_13195 ENOG4108K8S endonuclease I BSA41_13205 ENOG4108IHU transport system permease protein BSA41_13210 ENOG4105DQ5 transport system permease protein BSA41_13215 ENOG4108MES Periplasmic binding protein BSA41_13220 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BSA41_13230 ENOG4108SWU Histidine kinase BSA41_13235 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSA41_13240 ENOG4105DHF Membrane BSA41_13250 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BSA41_13260 ENOG4108IG5 Transcriptional regulator BSA41_13265 ENOG4105DIW FeS assembly protein SUFB BSA41_13270 ENOG4108UNV SUF system FeS assembly protein, NifU family BSA41_13275 ENOG4105C9B Cysteine desulfurase BSA41_13280 ENOG4105JRK feS assembly protein SufD BSA41_13285 ENOG4105C3K feS assembly ATPase SufC BSA41_13295 ENOG4105D01 (LipO)protein BSA41_13300 ENOG4108UMI ABC transporter, permease BSA41_13305 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BSA41_13330 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BSA41_13335 ENOG41080E8 Transcriptional regulator, Spx MgsR family BSA41_13340 ENOG4105C1G acyl-Coa dehydrogenase BSA41_13345 ENOG4105CHU acetyl-coa acetyltransferase BSA41_13370 ENOG4105E0A ABC, transporter BSA41_13380 ENOG4105E1F short-chain dehydrogenase reductase BSA41_13385 ENOG4105C0H protease BSA41_13395 ENOG4105F3H Histidine kinase BSA41_13400 ENOG41067SE Tetr family transcriptional regulator BSA41_13405 ENOG4105C9Q fumarate hydratase class II BSA41_13430 ENOG4105WH1 Two component transcriptional regulator luxr family BSA41_13435 ENOG4105ENE Histidine kinase BSA41_13450 ENOG41087YS Phage shock protein A BSA41_13460 ENOG4105ID8 Transcriptional regulator, ARAC family BSA41_13465 ENOG4105CPU Monooxygenase BSA41_13475 ENOG4105CAY ferredoxin--nadp reductase BSA41_13480 ENOG4108WBT adenosyltransferase BSA41_13485 ENOG4105E0A ABC, transporter BSA41_13490 ENOG4105EHG Permease protein BSA41_13495 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BSA41_13505 ENOG4105CTX dehydratase BSA41_13510 ENOG4107QZW Altronate oxidoreductase BSA41_13515 ENOG4107KJX Transcriptional regulator BSA41_13520 ENOG4105D2H Uronic isomerase BSA41_13530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BSA41_13535 ENOG4105E0A ABC, transporter BSA41_13540 ENOG4105EHG Permease protein BSA41_13545 ENOG4105DQ5 transport system permease protein BSA41_13555 ENOG4105D5Q Arginine ornithine antiporter BSA41_13570 ENOG4107K5X Membrane-bound metal-dependent hydrolase BSA41_13575 ENOG4107QZ2 Sulfatase BSA41_13580 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BSA41_13585 ENOG4105E0C molybdate abc transporter BSA41_13595 ENOG4105EVU fructokinase BSA41_13600 ENOG4107SUZ Sodium/hydrogen exchanger family BSA41_13605 ENOG4105EN6 Membrane BSA41_13615 ENOG4107ZQN disulfide bond BSA41_13620 ENOG4105C59 p-type ATPase BSA41_13625 ENOG4105DIK (ABC) transporter BSA41_13630 ENOG4105CC5 ABC transporter BSA41_13635 ENOG4105DSE periplasmic solute binding protein BSA41_13640 ENOG4105IIP Membrane BSA41_13645 ENOG4105W1N transcriptional regulator BSA41_13660 ENOG4108IJ0 Aspartate ammonia-lyase BSA41_13670 ENOG4105C59 p-type ATPase BSA41_13675 ENOG410681U heavy metal transport detoxification protein BSA41_13680 ENOG4105VPX protein, conserved in bacteria BSA41_13690 ENOG4105BZU Histidine kinase BSA41_13715 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BSA41_13720 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BSA41_13730 ENOG4105XZU Preprotein translocase, subunit SecG BSA41_13755 ENOG4105KVH Transcriptional regulator BSA41_13760 ENOG4105R40 Glycine betaine carnitine choline BSA41_13765 ENOG4108HQR Glycine betaine BSA41_13770 ENOG4105E90 ABC transporter BSA41_13775 ENOG4108IJ8 ABC transporter BSA41_13780 ENOG4107HG4 Transcriptional regulator BSA41_13785 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BSA41_13795 ENOG4108W0I acetyltransferase BSA41_13815 ENOG4108JJB ABC transporter BSA41_13825 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BSA41_13835 ENOG4105CP7 Triose-phosphate isomerase BSA41_13840 ENOG4105BZA Phosphoglycerate kinase BSA41_13845 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BSA41_13860 ENOG4105C8Y Acetylornithine aminotransferase BSA41_13865 ENOG4108JUB Transcriptional regulator BSA41_13870 ENOG4105JXH GntR family transcriptional regulator BSA41_13875 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BSA41_13885 ENOG4107R73 Mate efflux family protein BSA41_13890 ENOG4108JQ7 (ABC) transporter BSA41_13900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BSA41_13905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSA41_13910 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BSA41_13915 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BSA41_13920 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BSA41_13925 ENOG4105D3Q Sugar transferase BSA41_13940 ENOG4107QRS glycosyltransferase group 2 family protein BSA41_13945 ENOG41068W6 Capsular polysaccharide biosynthesis protein BSA41_13950 ENOG4108KMV Glycosyl transferase (Group 1 BSA41_13955 ENOG4105K64 Glycosyl transferase, family 2 BSA41_13960 ENOG4108PQP glycosyl transferase group 1 BSA41_13970 ENOG4108QV3 biosynthesis protein BSA41_13975 ENOG4105HTX biosynthesis protein BSA41_13990 ENOG4108V5C ABC transporter BSA41_13995 ENOG4105EHG Permease protein BSA41_14000 ENOG4105DQ5 transport system permease protein BSA41_14005 ENOG4108ZJ4 polysaccharide deacetylase BSA41_14030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BSA41_14035 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BSA41_14055 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BSA41_14080 ENOG4106128 DNA-binding helix-turn-helix protein BSA41_14085 ENOG41068WC Domain of unknown function (DUF955) BSA41_14125 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BSA41_14130 ENOG4108URH decarboxylase BSA41_14135 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BSA41_14140 ENOG4105CHH sulfate transporter BSA41_14145 ENOG4108V2W Carbonate dehydratase BSA41_14150 ENOG4105C5I Dehydrogenase BSA41_14160 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BSA41_14165 ENOG4105KRI phosphocarrier protein (HPr BSA41_14170 ENOG4105CIE May be required for sporulation (By similarity) BSA41_14175 ENOG4105CHW UPF0052 protein BSA41_14180 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BSA41_14185 ENOG4108Z4K mutator MutT protein BSA41_14190 ENOG4105C3M thioredoxin reductase BSA41_14205 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BSA41_14210 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BSA41_14215 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BSA41_14220 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BSA41_14225 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BSA41_14230 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BSA41_14235 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BSA41_14240 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BSA41_14255 ENOG4108RYK Nad-dependent epimerase dehydratase BSA41_14260 ENOG4108Z40 Transcriptional regulator BSA41_14265 ENOG4108S4C acetyltransferase BSA41_14270 ENOG4107XGZ Hydrolase BSA41_14275 ENOG4105HKU nucleoside recognition domain-containing protein BSA41_14285 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BSA41_14290 ENOG4105CE4 GlcNAc 6-P deacetylase BSA41_14295 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BSA41_14300 ENOG4105FDP GntR family transcriptional regulator BSA41_14305 ENOG41088CQ domain protein BSA41_14310 ENOG41086DT Membrane protein of unknown function BSA41_14315 ENOG41067S9 phage shock protein C, PspC BSA41_14320 ENOG4108PY7 BSA41_14335 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BSA41_14340 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BSA41_14355 ENOG4105MKU Transcriptional regulator BSA41_14370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSA41_14375 ENOG4105BZU Histidine kinase BSA41_14380 ENOG4105EDW glycosyl transferase, family 39 BSA41_14385 ENOG4105CKK Glycosyl transferase, family 2 BSA41_14395 ENOG4108RCM Nitroreductase BSA41_14400 ENOG4105KVH Transcriptional regulator BSA41_14415 ENOG4105CN1 protease BSA41_14430 ENOG4105CRP Part of the ABC transporter FtsEX involved in BSA41_14435 ENOG4105CAK Cell division ATP-binding protein ftsE BSA41_14460 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BSA41_14470 ENOG4105MS2 ribosomal subunit Interface protein BSA41_14475 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_14490 ENOG4105MQ3 flagellar protein FliS BSA41_14495 ENOG4107RT6 flagellar hook-associated BSA41_14500 ENOG41083S7 flagellar protein FlaG BSA41_14505 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BSA41_14510 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BSA41_14515 ENOG4105MKD BSA41_14520 ENOG4105DTJ flagellar hook-associated protein BSA41_14525 ENOG4105E1Q flagellar hook-associated protein BSA41_14540 ENOG4105RU3 BSA41_14545 ENOG41081UC Inherit from COG: Competence protein BSA41_14565 ENOG4105WH1 Two component transcriptional regulator luxr family BSA41_14570 ENOG4105BZU Histidine kinase BSA41_14575 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BSA41_14580 ENOG4108KGH TRANSCRIPTIONal BSA41_14585 ENOG4105ESV Glycosyl transferase, family 4 BSA41_14590 ENOG4107EF8 Glycosyl transferase (Group 1 BSA41_14605 ENOG4105QZI O-Antigen Polymerase BSA41_14610 ENOG4105C1B dTDP-glucose 4-6-dehydratase BSA41_14615 ENOG4105C6Y Udp-glucose 6-dehydrogenase BSA41_14620 ENOG4107RA4 Glycosyl transferase (Group 1 BSA41_14625 ENOG4105PSV Polysaccharide Biosynthesis Protein BSA41_14630 ENOG4105D3Q Sugar transferase BSA41_14640 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSA41_14645 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BSA41_14650 ENOG4105JFG SpoIID LytB domain protein BSA41_14665 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BSA41_14670 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BSA41_14675 ENOG4105EY8 ABC transporter BSA41_14690 ENOG4107SJB teichoic acid biosynthesis BSA41_14695 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BSA41_14700 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BSA41_14710 ENOG4107RZX Teichoic acid biosynthesis protein BSA41_14720 ENOG4105DG6 mannose-6-phosphate isomerase BSA41_14730 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BSA41_14735 ENOG4108JP0 extracellular solute-binding protein family 1 BSA41_14740 ENOG4107YTP response regulator receiver protein BSA41_14745 ENOG4105C2F Histidine kinase BSA41_14755 ENOG4105I4A GCN5-related N-acetyltransferase BSA41_14760 ENOG4108UHU Aldolase BSA41_14765 ENOG4105D7K pfkb domain protein BSA41_14770 ENOG4108M60 Transcriptional regulator BSA41_14775 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BSA41_14780 ENOG4105CHR reductase BSA41_14795 ENOG4108NHD germination protein BSA41_14800 ENOG4107QJZ Glycosyl transferase, family 2 BSA41_14805 ENOG4105C54 Major Facilitator superfamily BSA41_14810 ENOG4108KGH TRANSCRIPTIONal BSA41_14815 ENOG4105J7I hydrolase BSA41_14820 ENOG4105K4H Nlp p60 protein BSA41_14825 ENOG4105PNM synthesis protein BSA41_14835 ENOG4105N98 Capsule biosynthesis protein capB BSA41_14855 ENOG4105ETE Transcriptional regulator (LacI family BSA41_14860 ENOG4108RVA ribokinase BSA41_14865 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BSA41_14870 ENOG4105C2J ABC transporter BSA41_14875 ENOG4105CNN ABC, transporter BSA41_14880 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BSA41_14885 ENOG4107XC4 flavin reductase domain protein, FMN-binding BSA41_14890 ENOG4107RSM transcriptional regulator BSA41_14900 ENOG4107FQX Alpha-acetolactate decarboxylase BSA41_14910 ENOG4105CAH Chromate BSA41_14915 ENOG4105FGV Chromate BSA41_14920 ENOG4105C6Y Udp-glucose 6-dehydrogenase BSA41_14925 ENOG4105KBK Zinc finger, swim domain protein BSA41_14930 ENOG4105C0D helicase BSA41_14935 ENOG4105BZU Histidine kinase BSA41_14940 ENOG410667J hydrolase BSA41_14955 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BSA41_14960 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BSA41_14970 ENOG4105CGA flagellar basal-body rod protein FlgG BSA41_14980 ENOG4105DFF Rod shape-determining protein mreb BSA41_14985 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BSA41_14990 ENOG4107MII Sugar-specific transcriptional regulator TrmB BSA41_14995 ENOG4105CZM Major Facilitator BSA41_15000 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BSA41_15005 ENOG41080V3 Major Facilitator superfamily BSA41_15010 ENOG4105EAB amino acid AbC transporter BSA41_15015 ENOG4105E5Q amino acid AbC transporter BSA41_15025 ENOG4105BZU Histidine kinase BSA41_15035 ENOG4105FRN stage II sporulation protein BSA41_15040 ENOG4107TCE N-acetyltransferase BSA41_15075 ENOG4105WDJ 50S ribosomal protein L33 BSA41_15080 ENOG4105CKI cobalamin synthesis protein BSA41_15085 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BSA41_15095 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BSA41_15100 ENOG4105FCD Major Facilitator BSA41_15105 ENOG4108J2R molybdopterin oxidoreductase BSA41_15110 ENOG4108TF4 von Willebrand factor, type A BSA41_15125 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BSA41_15135 ENOG4106778 Protein of unknown function (DUF1146) BSA41_15145 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BSA41_15150 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BSA41_15155 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BSA41_15160 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BSA41_15180 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BSA41_15190 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BSA41_15195 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BSA41_15200 ENOG4108UIC UPF0340 protein BSA41_15205 ENOG4108YZG isomerase BSA41_15210 ENOG4107WAU Protein tyrosine phosphatase BSA41_15220 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BSA41_15230 ENOG4108ZXQ stage ii sporulation protein r BSA41_15240 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BSA41_15245 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BSA41_15255 ENOG4107TT2 Auxin Efflux Carrier BSA41_15260 ENOG4105C6K Malic enzyme BSA41_15265 ENOG4107104 thymidine kinase BSA41_15270 ENOG41082DI 50s ribosomal protein l31 BSA41_15275 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BSA41_15280 ENOG4105CBT Fructose-1,6-bisphosphatase BSA41_15285 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BSA41_15295 ENOG4105D2N Aldolase BSA41_15300 ENOG410812K response regulator receiver protein BSA41_15310 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BSA41_15350 ENOG4105C1G acyl-Coa dehydrogenase BSA41_15355 ENOG4105C1G acyl-Coa dehydrogenase BSA41_15360 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BSA41_15370 ENOG4105DF6 Fe-S oxidoreductase BSA41_15400 ENOG4105BZ1 (ABC) transporter BSA41_15405 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BSA41_15420 ENOG4105C75 arginyL-tRNA synthetase BSA41_15425 ENOG410684U Domain of unknown function (DUF1934) BSA41_15435 ENOG4105CYW agmatinase BSA41_15440 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BSA41_15445 ENOG4105BZ4 penicillin-binding protein BSA41_15450 ENOG4108XFG YwhD family BSA41_15455 ENOG4108Z4T Peptidase M50 BSA41_15460 ENOG41069HH 4-oxalocrotonate tautomerase BSA41_15495 ENOG4105DCI Phosphohydrolase BSA41_15500 ENOG4105QAT UPF0741 protein BSA41_15505 ENOG4108VCI transcription factor, rsfa family BSA41_15515 ENOG4107QZ7 Cellulose synthase catalytic subunit BSA41_15530 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BSA41_15550 ENOG4107EV6 Inherit from COG: YD repeat protein BSA41_15580 ENOG4105JSC dimethylmenaquinone methyltransferase BSA41_15590 ENOG4108IJ2 phosphate acetyltransferase BSA41_15595 ENOG4107JTW chlorite dismutase BSA41_15600 ENOG4105F27 Major Facilitator BSA41_15610 ENOG4105FCW Major Facilitator superfamily BSA41_15615 ENOG41061WN bacilysin biosynthesis protein BSA41_15625 ENOG4105CHR reductase BSA41_15630 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase BSA41_15635 ENOG4105CHM Aminotransferase BSA41_15645 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BSA41_15650 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BSA41_15655 ENOG4105C1B dTDP-glucose 4-6-dehydratase BSA41_15660 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BSA41_15665 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BSA41_15670 ENOG4107TY6 Acylneuraminate cytidylyltransferase BSA41_15680 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BSA41_15685 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BSA41_15730 ENOG4105C26 Dehydrogenase BSA41_15735 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BSA41_15740 ENOG4108RJ9 Glycosyl transferase, family 2 BSA41_15750 ENOG4105DWF phosphomethylpyrimidine kinase BSA41_15770 ENOG41069H0 dihydroorotase EC 3.5.2.3 BSA41_15780 ENOG4105C5Y PTS System BSA41_15795 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_15805 ENOG4105DEN Luciferase family BSA41_15810 ENOG4108DBC nitroreductase BSA41_15825 ENOG41060D1 Quinol oxidase BSA41_15830 ENOG4105CCU oxidase (Subunit III) BSA41_15835 ENOG4105BZ9 Cytochrome C oxidase, subunit I BSA41_15840 ENOG4105E2S oxidase) subunit II BSA41_15855 ENOG4105CMR udp-glucose 4-epimerase BSA41_15860 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BSA41_15875 ENOG4105WH5 Teichoic acid glycosylation protein BSA41_15915 ENOG4107U6I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BSA41_15920 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BSA41_15925 ENOG4105CMU LysR family (Transcriptional regulator BSA41_15935 ENOG41067MG lrgb family BSA41_15940 ENOG4105DR4 Methyltransferase BSA41_15955 ENOG4105E5Q amino acid AbC transporter BSA41_15960 ENOG4107R0W ABC transporter BSA41_15975 ENOG4105CNN ABC, transporter BSA41_15980 ENOG4105C2J ABC transporter BSA41_15985 ENOG4108QGH periplasmic BSA41_15990 ENOG4108M26 parallel beta-helix repeat protein BSA41_15995 ENOG4105CM2 brancheD-chain amino acid aminotransferase BSA41_16010 ENOG4105F8D glycoside hydrolase family 4 BSA41_16015 ENOG4105VCP PTS System BSA41_16020 ENOG4105CK1 PTS System BSA41_16025 ENOG4105VZJ PTS System BSA41_16030 ENOG4105EMD TRANSCRIPTIONal BSA41_16045 ENOG4107R37 Glutamate dehydrogenase BSA41_16065 ENOG4108J20 pectate lyase BSA41_16070 ENOG4108JJ8 (ABC) transporter BSA41_16075 ENOG4108JJ9 ABC, transporter BSA41_16080 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BSA41_16085 ENOG4105C4M (Ubiquinol oxidase) subunit I BSA41_16095 ENOG4105DQ5 transport system permease protein BSA41_16105 ENOG4105KFN sortase, SrtB family BSA41_16130 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) BSA41_16135 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) BSA41_16140 ENOG4105KVH Transcriptional regulator BSA41_16145 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BSA41_16150 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BSA41_16155 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BSA41_16165 ENOG4107BJW polysaccharide deacetylase BSA41_16170 ENOG4105VCP PTS System BSA41_16175 ENOG4105VZJ PTS System BSA41_16180 ENOG4105CS2 ec 3.2.1.21 BSA41_16185 ENOG4105CK1 PTS System BSA41_16190 ENOG4105EMD TRANSCRIPTIONal BSA41_16215 ENOG4105DFD Na H antiporter BSA41_16220 ENOG4108IJ0 Aspartate ammonia-lyase BSA41_16225 ENOG4105HDK L-asparaginase BSA41_16230 ENOG4108IMY Transcriptional regulator BSA41_16260 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BSA41_16275 ENOG4106KNT transcriptional regulator BSA41_16280 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BSA41_16290 ENOG4105C6Z Gluconate BSA41_16305 ENOG4105CS2 ec 3.2.1.21 BSA41_16310 ENOG4105C5Y PTS System BSA41_16315 ENOG4105CID antiterminator BSA41_16320 ENOG4108XI2 Domain of unknown function (DUF1963) BSA41_16330 ENOG4108W7F transporter, permease BSA41_16335 ENOG4108JJB ABC transporter BSA41_16340 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BSA41_16345 ENOG4105ETU transcriptional activator (TenA BSA41_16370 ENOG4107G87 m6 family metalloprotease domain protein BSA41_16375 ENOG41067V3 Antibiotic biosynthesis monooxygenase BSA41_16380 ENOG4108TVJ Nitroreductase BSA41_16385 ENOG4105FS7 Transcriptional regulator BSA41_16390 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BSA41_16395 ENOG4105D9N nucleoside BSA41_16400 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BSA41_16405 ENOG4107RHR regulatoR BSA41_16415 ENOG4105EXC Acyl-transferase BSA41_16420 ENOG4105DXI Major Facilitator superfamily BSA41_16440 ENOG410667J hydrolase BSA41_16445 ENOG4105W1Y Transcriptional regulator BSA41_16450 ENOG4105EE0 oxidoreductase BSA41_16455 ENOG4105FKZ Methyl-accepting chemotaxis BSA41_16465 ENOG4105F1N DNA alkylation repair BSA41_16470 ENOG4105C6Z Gluconate BSA41_16475 ENOG4105CMG Carbohydrate kinase BSA41_16480 ENOG4106KNT transcriptional regulator BSA41_16510 ENOG4105DUM transcriptional regulator, lysR family BSA41_16520 ENOG4107FKK extracellular solute-binding protein family 1 BSA41_16530 ENOG4105EG2 ABC transporter, permease BSA41_16540 ENOG4105C4C beta-galactosidase BSA41_16555 ENOG4108TU7 Inherit from COG: (ABC) transporter BSA41_16560 ENOG4105CJ1 ABC, transporter BSA41_16565 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BSA41_16570 ENOG4105BZW Glycerate kinase BSA41_16575 ENOG4107QQ0 gntp family BSA41_16580 ENOG4107VHA regulatoR BSA41_16585 ENOG4105YA8 Transcriptional regulator BSA41_16590 ENOG4107Y80 Major Facilitator superfamily BSA41_16600 ENOG4105C19 ABC transporter BSA41_16605 ENOG410780I phosphoprotein phosphatase activity BSA41_16610 ENOG4105CID antiterminator BSA41_16615 ENOG4105CS2 ec 3.2.1.21 BSA41_16620 ENOG4105C5Y PTS System BSA41_16650 ENOG4105C85 amino acid BSA41_16655 ENOG4105ETE Transcriptional regulator (LacI family BSA41_16670 ENOG4105E2X shikimate dehydrogenase BSA41_16705 ENOG4105CS2 ec 3.2.1.21 BSA41_16715 ENOG4108S3Y transcriptional regulator BSA41_16725 ENOG4105JAB phenazine biosynthesis protein, phzf family BSA41_16730 ENOG41080UQ Transcriptional regulator BSA41_16760 ENOG4108IMY Transcriptional regulator BSA41_16770 ENOG4108RWP Major Facilitator Superfamily protein BSA41_16775 ENOG4105WAB arsR family transcriptional regulator BSA41_16790 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BSA41_16795 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BSA41_16805 ENOG4108V7D UPF0397 protein BSA41_16825 ENOG4105WQG acetyltransferase BSA41_16830 ENOG4105C0H protease BSA41_16835 ENOG4105Q2H domain protein BSA41_16850 ENOG4105BZU Histidine kinase BSA41_16855 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BSA41_16880 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BSA41_16895 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BSA41_16900 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BSA41_16905 ENOG4105CDU Replicative dna helicase BSA41_16910 ENOG4106K80 BSA41_16915 ENOG4106K80 BSA41_16930 ENOG4105NIV Esterase BSA41_16935 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BSA41_16940 ENOG4105E4F Isochorismate synthase BSA41_16945 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BSA41_16950 ENOG4105WQI isochorismatase BSA41_16955 ENOG4105CEY Amp-dependent synthetase and ligase BSA41_16960 ENOG4105WQT MbtH domain protein BSA41_16965 ENOG410874W AraC family transcriptional regulator BSA41_16975 ENOG4108SA1 esterase BSA41_16980 ENOG4105DJ2 Major Facilitator Superfamily BSA41_16985 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BSA41_16990 ENOG4105BZR domain protein BSA41_16995 ENOG4108XMW Membrane BSA41_17000 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BSA41_17005 ENOG4108P49 AntiSigma factor BSA41_17010 ENOG4105JVQ RNA Polymerase BSA41_17020 ENOG4105CH6 catalase BSA41_17025 ENOG4105CS1 NAD(P)H quinone oxidoreductase BSA41_17030 ENOG4105FBA Phospholipase Carboxylesterase BSA41_17035 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BSA41_17040 ENOG4105E90 ABC transporter BSA41_17045 ENOG4108IJ8 ABC transporter BSA41_17055 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BSA41_17060 ENOG4108UUM single-stranded DNA-binding protein BSA41_17065 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BSA41_17070 ENOG4105C3G gtp-binding protein BSA41_17075 ENOG4105VDK protein, conserved in bacteria BSA41_17095 ENOG4108ZDA Sporulation protein YyaC BSA41_17100 ENOG4105FA0 parb-like partition protein BSA41_17105 ENOG4107QJE Chromosome Partitioning Protein BSA41_17120 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BSA41_17125 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BSA41_17130 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BSA41_17140 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BSA41_17145 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BSA41_17150 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BSA41_17155 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BSA41_17160 ENOG410848D S4 domain protein YaaA BSA41_17165 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BSA41_17175 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSA41_17180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BSA41_17215 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BSA41_17225 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BSA41_17230 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BSA41_17235 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BSA41_17240 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BSA41_17245 ENOG4105FKZ Methyl-accepting chemotaxis BSA41_17255 ENOG4105ZMH deoxynucleoside kinase BSA41_17265 ENOG4105VRS hydrolase family 18 BSA41_17270 ENOG4105GTG Isochorismatase BSA41_17275 ENOG4108Z6B deaminase BSA41_17285 ENOG4105C6E dna polymerase iii BSA41_17290 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BSA41_17295 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BSA41_17305 ENOG41067KS pro-sigma K processing BSA41_17345 ENOG4105CDW Resistance protein BSA41_17350 ENOG4105CXN decarboxylase BSA41_17355 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BSA41_17360 ENOG4105X0R protein from nitrogen regulatory protein P-II BSA41_17365 ENOG4105XVJ Protein of unknown function (DUF327) BSA41_17370 ENOG4105FA2 dna polymerase iii BSA41_17375 ENOG4105MA4 psp1 domain protein BSA41_17380 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) BSA41_17385 ENOG41060K3 Methyltransferase BSA41_17390 ENOG4105VC4 domain protein BSA41_17395 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BSA41_17400 ENOG4105KRN Transcriptional regulator, abrb family BSA41_17405 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BSA41_17410 ENOG4105F8V Hydrolase, tatD family BSA41_17415 ENOG41069ER domain protein BSA41_17425 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BSA41_17430 ENOG4105XFA sporulation peptidase YabG BSA41_17435 ENOG4105W42 Veg protein BSA41_17440 ENOG4105XEW small acid-soluble spore protein BSA41_17445 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BSA41_17450 ENOG4105DFT pur operon repressor BSA41_17455 ENOG4105KME endoribonuclease L-psp BSA41_17465 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BSA41_17470 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BSA41_17475 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BSA41_17480 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BSA41_17490 ENOG4108JA2 transcriptioN-repair coupling factor BSA41_17495 ENOG4108M14 stage v sporulation protein t BSA41_17505 ENOG4108IY2 MazG family BSA41_17510 ENOG41082I2 s4 domain protein BSA41_17515 ENOG4105VYY sporulation protein yabp BSA41_17530 ENOG41060GV RNA binding s1 domain protein BSA41_17560 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BSA41_17565 ENOG4108UGV hypoxanthine phosphoribosyltransferase BSA41_17570 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BSA41_17575 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BSA41_17580 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BSA41_17585 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BSA41_17590 ENOG4105C6T cysteine synthase BSA41_17595 ENOG4105CRQ synthase (Component I) BSA41_17600 ENOG4105DDQ anthranilate synthase BSA41_17605 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BSA41_17610 ENOG4105EEI dihydropteroate synthase BSA41_17615 ENOG4105KRF dihydroneopterin aldolase BSA41_17620 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BSA41_17630 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BSA41_17635 ENOG4105CRK lysyL-tRNA synthetase BSA41_17720 ENOG4108Z0C Uvrb UvrC protein BSA41_17725 ENOG41066A3 ATP guanido phosphotransferase BSA41_17735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BSA41_17740 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BSA41_17745 ENOG4105CTP PilT protein domain protein BSA41_17750 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BSA41_17755 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BSA41_17760 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BSA41_17765 ENOG4105D7W serine acetyltransferase BSA41_17770 ENOG4105C8N cysteinyl-tRNA synthetase BSA41_17775 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BSA41_17780 ENOG4105C2N RNA methyltransferase TrmH family group 3 BSA41_17785 ENOG4105M0M Tetracycline resistance protein BSA41_17800 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BSA41_17805 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BSA41_17810 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BSA41_17815 ENOG4108VZM 50s ribosomal protein L10 BSA41_17820 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BSA41_17825 ENOG4107Y49 methyltransferase BSA41_17830 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSA41_17835 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSA41_17840 ENOG4105XPM ribosomal protein BSA41_17845 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BSA41_17850 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BSA41_17855 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BSA41_17865 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BSA41_17870 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BSA41_17875 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BSA41_17880 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BSA41_17885 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BSA41_17890 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BSA41_17895 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BSA41_17900 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BSA41_17905 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BSA41_17910 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BSA41_17915 ENOG41082SA 50s ribosomal protein l29 BSA41_17920 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BSA41_17925 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BSA41_17930 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BSA41_17935 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BSA41_17945 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BSA41_17950 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BSA41_17955 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BSA41_17960 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BSA41_17965 ENOG4105VPB 50S ribosomal protein L30 BSA41_17970 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BSA41_17975 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BSA41_17980 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BSA41_17985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BSA41_17990 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BSA41_18000 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BSA41_18005 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BSA41_18010 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BSA41_18015 ENOG4108ZT0 50S ribosomal protein l17 BSA41_18020 ENOG4108JJB ABC transporter BSA41_18025 ENOG4108JJB ABC transporter BSA41_18030 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BSA41_18035 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BSA41_18040 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BSA41_18045 ENOG4108UJD 30S ribosomal protein S9 BSA41_18090 ENOG4105D1F ATP-binding protein BSA41_18105 ENOG4108NMV polysaccharide deacetylase BSA41_18135 ENOG4105CHH sulfate transporter BSA41_18145 ENOG4105EHZ conserved protein UCP016719 BSA41_18150 ENOG4105D17 glycoside hydrolase, family 3 domain protein BSA41_18170 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BSA41_18205 ENOG4105EMN RNA polymerase sigma factor BSA41_18215 ENOG4105C8B TIGR00159 family BSA41_18220 ENOG4107U5W ybbr family BSA41_18225 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BSA41_18230 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BSA41_18245 ENOG4105DA5 (ABC) transporter BSA41_18260 ENOG4108WUZ (ABC) transporter BSA41_18295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BSA41_18300 ENOG4105CXY transporter BSA41_18310 ENOG4105C7Z Conserved Protein BSA41_18325 ENOG4105XTG Pfam:DUF156 BSA41_18330 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BSA41_18335 ENOG4105WZW rhodanese family BSA41_18340 ENOG4105VFE sira family BSA41_18345 ENOG4107TPS domain protein BSA41_18350 ENOG4105VFE sira family BSA41_18355 ENOG41087NI Sulfite exporter TauE/SafE BSA41_18360 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) BSA41_18365 ENOG4108SUT Major Facilitator Superfamily BSA41_18385 ENOG4105EWC Purine nucleoside phosphorylase BSA41_18400 ENOG4107SCQ Iron-containing alcohol dehydrogenase BSA41_18405 ENOG4105C72 UPF0176 protein BSA41_18410 ENOG4107QTZ amino acid BSA41_18420 ENOG4105CID antiterminator BSA41_18425 ENOG4105C5Y PTS System BSA41_18430 ENOG4105CS2 ec 3.2.1.21 BSA41_18445 ENOG4105EMD TRANSCRIPTIONal BSA41_18455 ENOG4105C8I hydrolase, family 38 BSA41_18460 ENOG4105DM4 PTS System BSA41_18465 ENOG4108YRF PTS System BSA41_18470 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BSA41_18475 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_18490 ENOG4108IQI permease BSA41_18495 ENOG4108J5H Homocysteine s-methyltransferase BSA41_18500 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BSA41_18515 ENOG4105C2C drug resistance transporter, Bcr CflA BSA41_18535 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BSA41_18545 ENOG4105J7D transcriptional regulator BSA41_18555 ENOG4105E2A Dehydrogenase BSA41_18560 ENOG41067TZ transcriptional regulator, MarR family BSA41_18570 ENOG4105CUB amino acid BSA41_18580 ENOG4105D74 hydrolase BSA41_18590 ENOG4105CSV Glutaminase BSA41_18605 ENOG41060AI SEC-C motif BSA41_18615 ENOG4105WH1 Two component transcriptional regulator luxr family BSA41_18620 ENOG4105BZU Histidine kinase BSA41_18630 ENOG4107SET aldo keto reductase BSA41_18640 ENOG4107Y7X LytTR BSA41_18645 ENOG4108IUW ABC transporter BSA41_18650 ENOG4108SDH ABC, transporter BSA41_18670 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BSA41_18680 ENOG4105DEN Luciferase family BSA41_18685 ENOG4108N0M stress protein BSA41_18690 ENOG4106FN3 tellurium resistance protein BSA41_18695 ENOG4106FN3 tellurium resistance protein BSA41_18700 ENOG4107TS3 membrane protein, TerC BSA41_18725 ENOG4108TTB tellurium resistance protein BSA41_18735 ENOG4108IJ7 Glycine betaine BSA41_18740 ENOG4107SQ8 Glycine betaine BSA41_18770 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BSA41_18790 ENOG4105TRI Hydrolase BSA41_18825 ENOG4105EIG urea carboxylase-associated protein 1 BSA41_18830 ENOG4107RMH nh(3)-dependent nad( ) synthetase BSA41_18845 ENOG4105FF2 Type I DHQase BSA41_18850 ENOG4105C7K acetolactate synthase BSA41_18860 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BSA41_18865 ENOG4105DJB Major Facilitator Superfamily BSA41_18875 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region BSA41_18880 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BSA41_18885 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BSA41_18895 ENOG41079KZ Major Facilitator Superfamily BSA41_18900 ENOG41089UC methyltransferase, type 11 BSA41_18905 ENOG4105C5Q Transcriptional regulator BSA41_18910 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BSA41_18915 ENOG4105I82 acetyl xylan esterase BSA41_18925 ENOG410756H nucleotidyltransferase BSA41_18935 ENOG4105C26 Dehydrogenase BSA41_18940 ENOG4107YHD transcriptional regulator BSA41_18950 ENOG4105E5Q amino acid AbC transporter BSA41_18955 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein BSA41_18965 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein BSA41_18975 ENOG4108AQF aminoglycoside N(3)-acetyltransferase BSA41_18985 ENOG4105C8Q Methyl-accepting chemotaxis BSA41_19010 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BSA41_19015 ENOG4105F38 ABC transporter, permease BSA41_19025 ENOG4105CEY Amp-dependent synthetase and ligase