locus-tag class description CWD84_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CWD84_00015 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CWD84_00030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CWD84_00035 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CWD84_00050 ENOG4107QJE Chromosome Partitioning Protein CWD84_00055 ENOG4105FA0 parb-like partition protein CWD84_00060 ENOG4108ZDA Sporulation protein YyaC CWD84_00075 ENOG4105VDK protein, conserved in bacteria CWD84_00080 ENOG4108J2R molybdopterin oxidoreductase CWD84_00085 ENOG4105C3G gtp-binding protein CWD84_00090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CWD84_00095 ENOG4108UUM single-stranded DNA-binding protein CWD84_00100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CWD84_00110 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CWD84_00115 ENOG4105CGK Exodeoxyribonuclease III CWD84_00125 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CWD84_00135 ENOG4107FCW Abortive infection protein CWD84_00140 ENOG4105C7Z Conserved Protein CWD84_00145 ENOG4105C7Z Conserved Protein CWD84_00150 ENOG41068WC Domain of unknown function (DUF955) CWD84_00155 ENOG4108IMY Transcriptional regulator CWD84_00175 ENOG4108RYM conjugative transposon protein CWD84_00185 ENOG4106BHR ftsk SpoIIIE family protein CWD84_00190 ENOG4106128 DNA-binding helix-turn-helix protein CWD84_00240 ENOG4105P1M Domain of unknown function (DUF1874) CWD84_00250 ENOG4105K4H Nlp p60 protein CWD84_00280 ENOG4105C7Z Conserved Protein CWD84_00290 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CWD84_00300 ENOG4108RDQ ABC transporter CWD84_00340 ENOG4107Y9U Membrane CWD84_00350 ENOG41082BV acetyltransferase CWD84_00355 ENOG4108U05 Transcriptional regulator CWD84_00365 ENOG4105FS7 Transcriptional regulator CWD84_00370 ENOG4108TVJ Nitroreductase CWD84_00380 ENOG4107RSM transcriptional regulator CWD84_00395 ENOG4108WYP Transcriptional regulator CWD84_00400 ENOG4108HKT sucrose-6-phosphate hydrolase CWD84_00405 ENOG4105EDQ levansucrase EC 2.4.1.10 CWD84_00410 ENOG4108UZ3 Transporter CWD84_00415 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CWD84_00420 ENOG4105KVH Transcriptional regulator CWD84_00435 ENOG4108XMW Membrane CWD84_00440 ENOG4105BZR domain protein CWD84_00460 ENOG4105CPK Glycosyl transferase (Group 1 CWD84_00465 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CWD84_00475 ENOG4105JNK Glycosyl transferase (Group 1 CWD84_00495 ENOG4105CDU Replicative dna helicase CWD84_00500 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CWD84_00505 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CWD84_00535 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CWD84_00540 ENOG4105BZU Histidine kinase CWD84_00555 ENOG4105Q2H domain protein CWD84_00560 ENOG4105C0H protease CWD84_00575 ENOG4108JUB Transcriptional regulator CWD84_00580 ENOG41082BM Transcriptional regulator, arsr family CWD84_00590 ENOG4105C8Y Acetylornithine aminotransferase CWD84_00595 ENOG4108IQI permease CWD84_00600 ENOG41066UZ arginase EC 3.5.3.1 CWD84_00610 ENOG4105WQG acetyltransferase CWD84_00615 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) CWD84_00635 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CWD84_00640 ENOG4105D9P serine threonine protein kinase CWD84_00675 ENOG4105XRQ Xanthine dehydrogenase accessory factor CWD84_00695 ENOG4108XHQ (2Fe-2S)-binding domain protein CWD84_00700 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 CWD84_00705 ENOG4105C85 amino acid CWD84_00710 ENOG4108JU3 Alkyl hydroperoxide reductase CWD84_00715 ENOG4105D3R alkyl hydroperoxide reductase CWD84_00725 ENOG41085PJ rdd domain containing protein CWD84_00730 ENOG4105F27 Major Facilitator CWD84_00735 ENOG4105WAB arsR family transcriptional regulator CWD84_00745 ENOG4108ITS PQQ enzyme repeat CWD84_00750 ENOG4105C26 Dehydrogenase CWD84_00755 ENOG4105ST3 Transcriptional regulator CWD84_00760 ENOG4105ECK Fatty Acid Desaturase CWD84_00765 ENOG4108ZGX Histidine kinase CWD84_00770 ENOG4108S01 response regulator CWD84_00775 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CWD84_00785 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CWD84_00790 ENOG4107QNK )-transporter CWD84_00795 ENOG4105CPC Aldo Keto reductase CWD84_00805 ENOG4105C26 Dehydrogenase CWD84_00815 ENOG4105EDK PfkB domain protein CWD84_00825 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CWD84_00835 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CWD84_00840 ENOG4105F0H myo-inositol catabolism protein CWD84_00845 ENOG4105WZ4 isomerase CWD84_00850 ENOG4105D2N Aldolase CWD84_00880 ENOG4108V5C ABC transporter CWD84_00910 ENOG410667J hydrolase CWD84_00915 ENOG4107RHR regulatoR CWD84_00920 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CWD84_00925 ENOG4105D9N nucleoside CWD84_00930 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CWD84_00955 ENOG4105CS2 ec 3.2.1.21 CWD84_00960 ENOG4107YZX Universal stress protein CWD84_00970 ENOG4108NR7 pectate lyase CWD84_00975 ENOG4105CNA YD repeat protein CWD84_01055 ENOG4105C1J atp-dependent rna helicase CWD84_01060 ENOG4105DEU major facilitator superfamily CWD84_01065 ENOG4105CID antiterminator CWD84_01075 ENOG4105D4T Citrate transporter CWD84_01080 ENOG4105CH6 catalase CWD84_01100 ENOG4105DHI Methyltransferase CWD84_01115 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CWD84_01120 ENOG4105CMR udp-glucose 4-epimerase CWD84_01130 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CWD84_01145 ENOG4107BJW polysaccharide deacetylase CWD84_01150 ENOG4105D2K citrate carrier protein CWD84_01155 ENOG4105C4M (Ubiquinol oxidase) subunit I CWD84_01160 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CWD84_01165 ENOG4108JJ9 ABC, transporter CWD84_01170 ENOG4108JJ8 (ABC) transporter CWD84_01175 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CWD84_01180 ENOG4105ETS cytosine purines uracil thiamine allantoin CWD84_01185 ENOG4107QHE Choloylglycine hydrolase CWD84_01190 ENOG4105CH6 catalase CWD84_01195 ENOG4107R5R arsenical pump membrane protein CWD84_01200 ENOG41082YX Transcriptional regulator, arsr family CWD84_01205 ENOG4108V5C ABC transporter CWD84_01210 ENOG4105EHG Permease protein CWD84_01215 ENOG4105DQ5 transport system permease protein CWD84_01230 ENOG4105EMD TRANSCRIPTIONal CWD84_01235 ENOG4105VZJ PTS System CWD84_01240 ENOG4105CK1 PTS System CWD84_01245 ENOG4105VCP PTS System CWD84_01250 ENOG4105F8D glycoside hydrolase family 4 CWD84_01275 ENOG4105C26 Dehydrogenase CWD84_01285 ENOG4105CM2 brancheD-chain amino acid aminotransferase CWD84_01290 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CWD84_01295 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) CWD84_01300 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CWD84_01305 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) CWD84_01325 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CWD84_01335 ENOG4105X1N Glycosyl transferase family 8 CWD84_01340 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CWD84_01345 ENOG4105CK1 PTS System CWD84_01355 ENOG4105DR4 Methyltransferase CWD84_01365 ENOG41067MG lrgb family CWD84_01370 ENOG4105VAW lrga family CWD84_01375 ENOG4105CMU LysR family (Transcriptional regulator CWD84_01380 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase CWD84_01385 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CWD84_01390 ENOG4107SJW iron permease, FTR1 CWD84_01395 ENOG410650H (LipO)protein CWD84_01400 ENOG4105DBE peroxidase CWD84_01405 ENOG4107ZXU DSBA oxidoreductase CWD84_01415 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) CWD84_01430 ENOG4105WH5 Teichoic acid glycosylation protein CWD84_01435 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CWD84_01445 ENOG4107BMA Transglycosylase associated protein CWD84_01450 ENOG4105E2S oxidase) subunit II CWD84_01455 ENOG4105BZ9 Cytochrome C oxidase, subunit I CWD84_01475 ENOG4105I4A GCN5-related N-acetyltransferase CWD84_01485 ENOG4108DBC nitroreductase CWD84_01490 ENOG4105DEN Luciferase family CWD84_01495 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CWD84_01510 ENOG4105C5Y PTS System CWD84_01525 ENOG4105DWF phosphomethylpyrimidine kinase CWD84_01545 ENOG4108RJ9 Glycosyl transferase, family 2 CWD84_01550 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CWD84_01585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CWD84_01590 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD CWD84_01600 ENOG4107TY6 Acylneuraminate cytidylyltransferase CWD84_01605 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG CWD84_01610 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CWD84_01615 ENOG4105C1B dTDP-glucose 4-6-dehydratase CWD84_01620 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CWD84_01625 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase CWD84_01630 ENOG4105D82 Glutamate dehydrogenase CWD84_01635 ENOG4105C26 Dehydrogenase CWD84_01650 ENOG4105C2C drug resistance transporter, Bcr CflA CWD84_01655 ENOG4105FCW Major Facilitator superfamily CWD84_01685 ENOG4105CHM Aminotransferase CWD84_01695 ENOG4107JTW chlorite dismutase CWD84_01700 ENOG4108IJ2 phosphate acetyltransferase CWD84_01705 ENOG4105HMI Membrane CWD84_01710 ENOG4105DUM transcriptional regulator, lysR family CWD84_01715 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CWD84_01740 ENOG4108TU7 Inherit from COG: (ABC) transporter CWD84_01745 ENOG4105CJ1 ABC, transporter CWD84_01755 ENOG4105K7K Transcriptional regulator CWD84_01760 ENOG4108VCI transcription factor, rsfa family CWD84_01770 ENOG4105DCI Phosphohydrolase CWD84_01780 ENOG4105CUB amino acid CWD84_01790 ENOG41067TZ transcriptional regulator, MarR family CWD84_01795 ENOG41069HH 4-oxalocrotonate tautomerase CWD84_01800 ENOG4108Z4T Peptidase M50 CWD84_01805 ENOG4108XFG YwhD family CWD84_01815 ENOG4105BZ4 penicillin-binding protein CWD84_01820 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CWD84_01825 ENOG4105CYW agmatinase CWD84_01835 ENOG4107JM4 Tetratricopeptide repeat CWD84_01840 ENOG410684U Domain of unknown function (DUF1934) CWD84_01845 ENOG4105C75 arginyL-tRNA synthetase CWD84_01855 ENOG4107V6Q Cyclic nucleotide-binding domain CWD84_01875 ENOG4108IUE nitrate reductase beta subunit CWD84_01880 ENOG4105R3A Nitrate reductase CWD84_01895 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CWD84_01900 ENOG4105BZ1 (ABC) transporter CWD84_01910 ENOG4105E5J UV damage endonuclease CWD84_01920 ENOG4105DF6 Fe-S oxidoreductase CWD84_01930 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CWD84_01940 ENOG410812K response regulator receiver protein CWD84_01945 ENOG4105D2N Aldolase CWD84_01955 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CWD84_01960 ENOG4105CBT Fructose-1,6-bisphosphatase CWD84_01970 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CWD84_01975 ENOG41082DI 50s ribosomal protein l31 CWD84_01980 ENOG4107104 thymidine kinase CWD84_01985 ENOG4105C6K Malic enzyme CWD84_01990 ENOG4107TT2 Auxin Efflux Carrier CWD84_02000 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CWD84_02005 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CWD84_02010 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CWD84_02025 ENOG4108ZXQ stage ii sporulation protein r CWD84_02035 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CWD84_02040 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CWD84_02045 ENOG4107WAU Protein tyrosine phosphatase CWD84_02050 ENOG4108YZG isomerase CWD84_02055 ENOG4108UIC UPF0340 protein CWD84_02060 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CWD84_02065 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CWD84_02075 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) CWD84_02090 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) CWD84_02095 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CWD84_02100 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CWD84_02105 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CWD84_02110 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CWD84_02120 ENOG4106778 Protein of unknown function (DUF1146) CWD84_02130 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CWD84_02150 ENOG4108TF4 von Willebrand factor, type A CWD84_02155 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CWD84_02160 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CWD84_02180 ENOG4108YZ9 Urea amidohydrolase subunit gamma CWD84_02185 ENOG4105KI2 Urea amidohydrolase subunit beta CWD84_02190 ENOG4105CQM Urea amidohydrolase subunit alpha CWD84_02195 ENOG4108Z40 Transcriptional regulator CWD84_02200 ENOG4107T94 Endo-14-beta-xylanase CWD84_02205 ENOG4106BRK CWD84_02210 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CWD84_02225 ENOG4107TCE N-acetyltransferase CWD84_02230 ENOG4105FRN stage II sporulation protein CWD84_02240 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CWD84_02245 ENOG4105CNI cell division protein FtsW CWD84_02255 ENOG4105BZU Histidine kinase CWD84_02260 ENOG4105D3W isochorismatase CWD84_02265 ENOG41080V3 Major Facilitator superfamily CWD84_02270 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CWD84_02275 ENOG4105CZM Major Facilitator CWD84_02280 ENOG4107MII Sugar-specific transcriptional regulator TrmB CWD84_02285 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CWD84_02290 ENOG4105DFF Rod shape-determining protein mreb CWD84_02300 ENOG4105CGA flagellar basal-body rod protein FlgG CWD84_02310 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CWD84_02315 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CWD84_02330 ENOG4105Z8H single-stranded DNA-binding protein CWD84_02335 ENOG4105E98 transcriptional regulator DeoR family CWD84_02340 ENOG410667J hydrolase CWD84_02345 ENOG4105C0D helicase CWD84_02350 ENOG4105KBK Zinc finger, swim domain protein CWD84_02360 ENOG4105HTX biosynthesis protein CWD84_02365 ENOG4107YJ4 chain length determinant protein CWD84_02370 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CWD84_02375 ENOG4105C6Y Udp-glucose 6-dehydrogenase CWD84_02410 ENOG4105FGV Chromate CWD84_02415 ENOG4105CAH Chromate CWD84_02425 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CWD84_02435 ENOG4107XC4 flavin reductase domain protein, FMN-binding CWD84_02450 ENOG4106UIA CWD84_02465 ENOG4107RSM transcriptional regulator CWD84_02475 ENOG4107FQX Alpha-acetolactate decarboxylase CWD84_02480 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CWD84_02490 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CWD84_02495 ENOG4105CNN ABC, transporter CWD84_02500 ENOG4105C2J ABC transporter CWD84_02505 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CWD84_02510 ENOG4108RVA ribokinase CWD84_02515 ENOG4105ETE Transcriptional regulator (LacI family CWD84_02530 ENOG4105N98 Capsule biosynthesis protein capB CWD84_02540 ENOG4105PNM synthesis protein CWD84_02555 ENOG4105K4H Nlp p60 protein CWD84_02560 ENOG4106UBQ CWD84_02565 ENOG4105J7I hydrolase CWD84_02570 ENOG4108KGH TRANSCRIPTIONal CWD84_02575 ENOG4105C54 Major Facilitator superfamily CWD84_02580 ENOG4105K64 Glycosyl transferase, family 2 CWD84_02585 ENOG4108NHD germination protein CWD84_02600 ENOG4105DG6 mannose-6-phosphate isomerase CWD84_02610 ENOG4107RZX Teichoic acid biosynthesis protein CWD84_02620 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase CWD84_02630 ENOG4107SJB teichoic acid biosynthesis CWD84_02640 ENOG4105EY8 ABC transporter CWD84_02645 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CWD84_02650 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CWD84_02665 ENOG4105JFG SpoIID LytB domain protein CWD84_02670 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CWD84_02675 ENOG4105D3Q Sugar transferase CWD84_02680 ENOG4105PSV Polysaccharide Biosynthesis Protein CWD84_02685 ENOG4107RA4 Glycosyl transferase (Group 1 CWD84_02690 ENOG4105C6Y Udp-glucose 6-dehydrogenase CWD84_02695 ENOG4105QZI O-Antigen Polymerase CWD84_02710 ENOG4107EF8 Glycosyl transferase (Group 1 CWD84_02715 ENOG4105ESV Glycosyl transferase, family 4 CWD84_02720 ENOG4108KGH TRANSCRIPTIONal CWD84_02725 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CWD84_02730 ENOG4105BZU Histidine kinase CWD84_02735 ENOG4105WH1 Two component transcriptional regulator luxr family CWD84_02755 ENOG41081UC Inherit from COG: Competence protein CWD84_02760 ENOG4105RU3 CWD84_02775 ENOG4105E1Q flagellar hook-associated protein CWD84_02780 ENOG4105DTJ flagellar hook-associated protein CWD84_02790 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) CWD84_02795 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CWD84_02800 ENOG4105I03 Flagellin CWD84_02805 ENOG4107RT6 flagellar hook-associated CWD84_02810 ENOG4105MQ3 flagellar protein FliS CWD84_02825 ENOG4105MS2 ribosomal subunit Interface protein CWD84_02830 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CWD84_02850 ENOG4105CAK Cell division ATP-binding protein ftsE CWD84_02855 ENOG4105CRP Part of the ABC transporter FtsEX involved in CWD84_02860 ENOG4108M26 parallel beta-helix repeat protein CWD84_02865 ENOG4105CN1 protease CWD84_02890 ENOG4105MKU Transcriptional regulator CWD84_02905 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CWD84_02910 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CWD84_02925 ENOG4108PY7 CWD84_02930 ENOG41067S9 phage shock protein C, PspC CWD84_02935 ENOG41086DT Membrane protein of unknown function CWD84_02940 ENOG41088CQ domain protein CWD84_02945 ENOG4105J7D transcriptional regulator CWD84_02950 ENOG4105FDP GntR family transcriptional regulator CWD84_02955 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CWD84_02960 ENOG4105CE4 GlcNAc 6-P deacetylase CWD84_02965 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CWD84_02975 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) CWD84_02980 ENOG4108S4C acetyltransferase CWD84_02990 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CWD84_02995 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CWD84_03000 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CWD84_03005 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CWD84_03010 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CWD84_03015 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CWD84_03020 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CWD84_03025 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CWD84_03030 ENOG4105BZ1 (ABC) transporter CWD84_03035 ENOG4105GIG CWD84_03040 ENOG4105EFI regulatoR CWD84_03045 ENOG4105BZU Histidine kinase CWD84_03065 ENOG4105C3M thioredoxin reductase CWD84_03070 ENOG4108Z4K mutator MutT protein CWD84_03075 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CWD84_03080 ENOG4105CHW UPF0052 protein CWD84_03085 ENOG4105CIE May be required for sporulation (By similarity) CWD84_03090 ENOG4105KRI phosphocarrier protein (HPr CWD84_03095 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CWD84_03100 ENOG4105GGE ribonuclease CWD84_03105 ENOG4105C5I Dehydrogenase CWD84_03115 ENOG4108V2W Carbonate dehydratase CWD84_03120 ENOG4105CHH sulfate transporter CWD84_03125 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain CWD84_03130 ENOG4108URH decarboxylase CWD84_03145 ENOG4105C7F AcnD-accessory protein PrpF CWD84_03150 ENOG4108KAM Transcriptional regulator CWD84_03155 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CWD84_03160 ENOG4105ETE Transcriptional regulator (LacI family CWD84_03170 ENOG4108HKT sucrose-6-phosphate hydrolase CWD84_03235 ENOG4105NI3 Protein of unknown function (DUF3237) CWD84_03240 ENOG4105PY6 Phenolic acid decarboxylase CWD84_03245 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CWD84_03255 ENOG4105NAE bifunctional deaminase-reductase domain protein CWD84_03265 ENOG4105EBR Carboxylesterase CWD84_03275 ENOG4105HTX biosynthesis protein CWD84_03280 ENOG4108QV3 biosynthesis protein CWD84_03290 ENOG4108PQP glycosyl transferase group 1 CWD84_03295 ENOG4105K64 Glycosyl transferase, family 2 CWD84_03300 ENOG4108KMV Glycosyl transferase (Group 1 CWD84_03305 ENOG41068W6 Capsular polysaccharide biosynthesis protein CWD84_03310 ENOG4107QRS glycosyltransferase group 2 family protein CWD84_03320 ENOG4105K64 Glycosyl transferase, family 2 CWD84_03330 ENOG4105D3Q Sugar transferase CWD84_03335 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CWD84_03340 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CWD84_03345 ENOG4108ZPC Polysaccharide pyruvyl transferase CWD84_03355 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWD84_03360 ENOG4105DAA L-lactate CWD84_03365 ENOG4105JXH GntR family transcriptional regulator CWD84_03370 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CWD84_03375 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CWD84_03380 ENOG4107QR9 Iron-sulfur cluster binding protein CWD84_03390 ENOG4105C6Z Gluconate CWD84_03395 ENOG4105CMG Carbohydrate kinase CWD84_03400 ENOG4106KNT transcriptional regulator CWD84_03415 ENOG4107RT3 EamA-like transporter family CWD84_03420 ENOG4105GZI Transcriptional regulator CWD84_03430 ENOG4105DEN Luciferase family CWD84_03435 ENOG4105CMD Transcriptional regulator, GntR family CWD84_03450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CWD84_03460 ENOG4105BZA Phosphoglycerate kinase CWD84_03465 ENOG4105CP7 Triose-phosphate isomerase CWD84_03470 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CWD84_03475 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CWD84_03480 ENOG4108W0I acetyltransferase CWD84_03485 ENOG4105T65 Membrane-associated protein CWD84_03505 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CWD84_03510 ENOG4107HG4 Transcriptional regulator CWD84_03515 ENOG4108IJ8 ABC transporter CWD84_03520 ENOG4105E90 ABC transporter CWD84_03525 ENOG4108HQR Glycine betaine CWD84_03530 ENOG4105R40 Glycine betaine carnitine choline CWD84_03535 ENOG4107HG4 Transcriptional regulator CWD84_03540 ENOG4108IJ8 ABC transporter CWD84_03550 ENOG4108HQR Glycine betaine CWD84_03555 ENOG4105R40 Glycine betaine carnitine choline CWD84_03560 ENOG4105DA5 (ABC) transporter CWD84_03585 ENOG4105KVH Transcriptional regulator CWD84_03605 ENOG4105XZU Preprotein translocase, subunit SecG CWD84_03615 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CWD84_03620 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CWD84_03645 ENOG41067XF inhibitor CWD84_03650 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CWD84_03655 ENOG4108KSA LysR family transcriptional regulator CWD84_03660 ENOG4108XSB acetyltransferase, (GNAT) family CWD84_03685 ENOG4105CDA abc transporter atp-binding protein CWD84_03690 ENOG4105DEN Luciferase family CWD84_03730 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CWD84_03735 ENOG4105D9R oxidoreductase CWD84_03740 ENOG4105VPX protein, conserved in bacteria CWD84_03745 ENOG410681U heavy metal transport detoxification protein CWD84_03750 ENOG4105C59 p-type ATPase CWD84_03755 ENOG4105C59 p-type ATPase CWD84_03760 ENOG4107ZQN disulfide bond CWD84_03775 ENOG4105EN6 Membrane CWD84_03780 ENOG4105EEM helicase CWD84_03785 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CWD84_03790 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CWD84_03800 ENOG4105EEQ Na H antiporter CWD84_03815 ENOG4108KYE ABC-2 type transporter CWD84_03825 ENOG4105CJ1 ABC, transporter CWD84_03830 ENOG4105BZU Histidine kinase CWD84_03835 ENOG4105WH1 Two component transcriptional regulator luxr family CWD84_03840 ENOG4105E0C molybdate abc transporter CWD84_03845 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CWD84_03850 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CWD84_03860 ENOG4107QZ2 Sulfatase CWD84_03865 ENOG4107K5X Membrane-bound metal-dependent hydrolase CWD84_03880 ENOG4105D5Q Arginine ornithine antiporter CWD84_03885 ENOG4105JQZ Methyltransferase CWD84_03895 ENOG4105DQ5 transport system permease protein CWD84_03900 ENOG4105EHG Permease protein CWD84_03905 ENOG4105E0A ABC, transporter CWD84_03915 ENOG4105F0F Oxalate decarboxylase CWD84_03930 ENOG4106DF4 Sigma-70, region 4 CWD84_03940 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CWD84_03950 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CWD84_03955 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CWD84_03960 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CWD84_03965 ENOG4105EHG Permease protein CWD84_03970 ENOG4105E0A ABC, transporter CWD84_03975 ENOG4108WBT adenosyltransferase CWD84_03990 ENOG41087YS Phage shock protein A CWD84_04005 ENOG4105ENE Histidine kinase CWD84_04010 ENOG4105WH1 Two component transcriptional regulator luxr family CWD84_04035 ENOG4105C9Q fumarate hydratase class II CWD84_04040 ENOG41067SE Tetr family transcriptional regulator CWD84_04050 ENOG4105F3H Histidine kinase CWD84_04060 ENOG4105C0H protease CWD84_04065 ENOG4105HUF DNA protection during starvation protein CWD84_04070 ENOG4105E1F short-chain dehydrogenase reductase CWD84_04085 ENOG4105E0A ABC, transporter CWD84_04105 ENOG4105MDS 4-oxalocrotonate tautomerase CWD84_04110 ENOG4105C0R drug resistance transporter emrb qaca subfamily CWD84_04115 ENOG41067TZ transcriptional regulator, MarR family CWD84_04145 ENOG4105CHU acetyl-coa acetyltransferase CWD84_04150 ENOG4105C1G acyl-Coa dehydrogenase CWD84_04155 ENOG41080E8 Transcriptional regulator, Spx MgsR family CWD84_04160 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CWD84_04185 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CWD84_04190 ENOG4108UMI ABC transporter, permease CWD84_04195 ENOG4105D01 (LipO)protein CWD84_04210 ENOG4105C3K feS assembly ATPase SufC CWD84_04215 ENOG4105JRK feS assembly protein SufD CWD84_04220 ENOG4105C9B Cysteine desulfurase CWD84_04225 ENOG4108UNV SUF system FeS assembly protein, NifU family CWD84_04230 ENOG4105DIW FeS assembly protein SUFB CWD84_04265 ENOG41090VF Stage v sporulation protein ac CWD84_04270 ENOG4105CZ3 stage V sporulation protein ad CWD84_04285 ENOG4108QY0 Membrane CWD84_04320 ENOG4107VFR oxidoreductase CWD84_04325 ENOG4105PKS Excinuclease abc c subunit domain protein CWD84_04350 ENOG4108Z6Z Transcriptional regulator CWD84_04355 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine CWD84_04360 ENOG4105XN3 extracellular solute-binding protein family 1 CWD84_04365 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CWD84_04370 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CWD84_04375 ENOG4108KPW sugar kinase CWD84_04380 ENOG4105FDP GntR family transcriptional regulator CWD84_04385 ENOG4108IJ9 (ABC) transporter CWD84_04395 ENOG4105E2Y ABC, transporter CWD84_04400 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CWD84_04405 ENOG4105GVF (ABC) transporter CWD84_04415 ENOG4108K8S endonuclease I CWD84_04425 ENOG4105C5R Aminotransferase CWD84_04430 ENOG4105XRQ Xanthine dehydrogenase accessory factor CWD84_04445 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CWD84_04450 ENOG4107YV9 domain protein CWD84_04460 ENOG4105VT2 5-hydroxyisourate hydrolase CWD84_04465 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) CWD84_04480 ENOG4105G9B Transcriptional regulator CWD84_04485 ENOG4105CD3 dihydroorotase CWD84_04495 ENOG4105I3N Conserved Protein CWD84_04505 ENOG4107R8B 5'-nucleotidase CWD84_04510 ENOG4108YTE sporulation protein YunB CWD84_04515 ENOG4105FAA peptidase M23 CWD84_04520 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CWD84_04530 ENOG4105MMD transcriptional regulator CWD84_04540 ENOG4105D4U had-superfamily hydrolase, subfamily iia CWD84_04545 ENOG4108W5N phosphatidylglycerophosphatase a CWD84_04560 ENOG4105D6E homoserine dehydrogenase CWD84_04565 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CWD84_04570 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CWD84_04575 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CWD84_04580 ENOG41083MR nifu domain-containing protein CWD84_04595 ENOG4105ZKE UPF0349 protein CWD84_04605 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CWD84_04610 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CWD84_04615 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CWD84_04720 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CWD84_04745 ENOG4105CJ1 ABC, transporter CWD84_04760 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) CWD84_04775 ENOG4105CEP NADH dehydrogenase CWD84_04790 ENOG41069ER domain protein CWD84_04800 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CWD84_04820 ENOG4105NIV Esterase CWD84_04825 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CWD84_04830 ENOG4105E4F Isochorismate synthase CWD84_04835 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CWD84_04840 ENOG4105WQI isochorismatase CWD84_04845 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_04850 ENOG4105WQT MbtH domain protein CWD84_04860 ENOG4105DCF alanine dehydrogenase CWD84_04865 ENOG4108K8K Transcriptional regulator CWD84_04900 ENOG410904N short-chain dehydrogenase reductase CWD84_04915 ENOG4105C02 permease CWD84_04940 ENOG4105DAP Nicotinate phosphoribosyltransferase CWD84_04945 ENOG4105D58 Diguanylate phosphodiesterase CWD84_04975 ENOG4105BZU Histidine kinase CWD84_04985 ENOG4105KA0 thioesterase Superfamily protein CWD84_04990 ENOG4105KJM monovalent cation h antiporter subunit g CWD84_05000 ENOG4105SC1 monovalent cation H antiporter subunit E CWD84_05005 ENOG4108JPZ Monovalent cation H antiporter subunit D CWD84_05010 ENOG4108ZE9 Monovalent cation H antiporter subunit C CWD84_05015 ENOG4105HC0 Na H antiporter CWD84_05020 ENOG4105D65 subunit l CWD84_05035 ENOG4105UIB (ABC) transporter CWD84_05040 ENOG4108JQ9 ABC transporter CWD84_05045 ENOG4105DIH basic membrane CWD84_05050 ENOG4108MRH transcriptional regulatory protein CWD84_05065 ENOG4105KIR Thiol-disulfide oxidoreductase dcc CWD84_05070 ENOG4105BZ4 penicillin-binding protein CWD84_05085 ENOG4105Y38 Kinase-associated protein B CWD84_05090 ENOG4108HGU Histidine kinase CWD84_05095 ENOG4105C87 Aminotransferase class I and II CWD84_05105 ENOG4108MUZ hydrolase CWD84_05110 ENOG4108ZB6 transcriptional regulator AsnC family CWD84_05115 ENOG4105CHM Aminotransferase CWD84_05125 ENOG4105WG9 Conserved Protein CWD84_05130 ENOG4107QW4 alcohol dehydrogenase CWD84_05140 ENOG4105CHJ isochorismatase hydrolase CWD84_05150 ENOG4107QYV phosphohexose isomerase CWD84_05165 ENOG4107PBV potassium channel CWD84_05170 ENOG4107PBV potassium channel CWD84_05185 ENOG4105C37 (CBS) domain CWD84_05195 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CWD84_05200 ENOG4105EA8 2-Nitropropane dioxygenase CWD84_05215 ENOG4105C8Q Methyl-accepting chemotaxis CWD84_05220 ENOG4105C8Q Methyl-accepting chemotaxis CWD84_05225 ENOG4105C8Q Methyl-accepting chemotaxis CWD84_05230 ENOG4105C8Q Methyl-accepting chemotaxis CWD84_05235 ENOG4108Z0Z intracellular protease Pfpi family CWD84_05240 ENOG4105EE0 oxidoreductase CWD84_05250 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CWD84_05285 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CWD84_05290 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_05305 ENOG4105TRT Transcriptional regulator CWD84_05310 ENOG4105C26 Dehydrogenase CWD84_05315 ENOG4108JB8 alcohol dehydrogenase CWD84_05320 ENOG4108VNY MOSC domain protein CWD84_05325 ENOG4106DF1 CWD84_05335 ENOG4105DZ6 Band 7 protein CWD84_05340 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CWD84_05475 ENOG4105E4F Isochorismate synthase CWD84_05480 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CWD84_05485 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CWD84_05490 ENOG4108IPT Naphthoate synthase CWD84_05495 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_05500 ENOG4105DTQ mandelate racemase muconate lactonizing CWD84_05525 ENOG4105NRA 50s ribosomal protein l31 type b CWD84_05530 ENOG4108V2W Carbonate dehydratase CWD84_05535 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CWD84_05540 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CWD84_05555 ENOG4108RMU ferritin dps family protein CWD84_05570 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CWD84_05580 ENOG4105D2X ABC transporter substrate-binding protein CWD84_05595 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CWD84_05600 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CWD84_05605 ENOG4105CAQ asparagine synthetase CWD84_05610 ENOG4105C85 amino acid CWD84_05615 ENOG4108Z0R Transferase CWD84_05620 ENOG4105E8V Alpha Beta Hydrolase Fold protein CWD84_05645 ENOG4105N5T Radical SAM Protein CWD84_05665 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CWD84_05670 ENOG4105DVE abc transporter atp-binding protein CWD84_05690 ENOG4105C19 ABC transporter CWD84_05695 ENOG4107R34 abc transporter permease protein CWD84_05705 ENOG4105EWM Histidine kinase CWD84_05710 ENOG4105C19 ABC transporter CWD84_05725 ENOG410605W Major Facilitator CWD84_05730 ENOG4105BZU Histidine kinase CWD84_05740 ENOG4105C8T Leucyl-tRNA synthetase CWD84_05745 ENOG41085GJ domain protein CWD84_05765 ENOG4105C94 Transporter CWD84_05770 ENOG4105CBX hi0933 family CWD84_05785 ENOG4105YW5 deoR family transcriptional regulator CWD84_05800 ENOG4105C7N Xanthine uracil vitamin C permease CWD84_05805 ENOG4107QSE Dipeptidase CWD84_05810 ENOG4105C6T cysteine synthase CWD84_05815 ENOG4107F58 2'-5' rna ligase CWD84_05830 ENOG4108V15 phosphotransferase enzyme family CWD84_05840 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CWD84_05845 ENOG4105C8F Beta-lactamase domain protein CWD84_05850 ENOG4105C6K Malic enzyme CWD84_05865 ENOG4105H67 Protein of unknown function (DUF421) CWD84_05870 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CWD84_05880 ENOG4108QY0 Membrane CWD84_05895 ENOG4105CZ3 stage V sporulation protein ad CWD84_05900 ENOG41090VF Stage v sporulation protein ac CWD84_05930 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CWD84_05970 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CWD84_05985 ENOG4108VDD TRNA binding domain protein CWD84_05995 ENOG4105DFU Cell wall formation (By similarity) CWD84_06015 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CWD84_06020 ENOG4105ETE Transcriptional regulator (LacI family CWD84_06025 ENOG4107R0U MotA TolQ exbB proton channel CWD84_06030 ENOG4105ER2 Ompa motb domain protein CWD84_06035 ENOG4105DGU Histone deacetylase CWD84_06040 ENOG4105W87 Cbs domain CWD84_06045 ENOG4105F1V Acetoin utilization protein CWD84_06060 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CWD84_06075 ENOG4108NGU Transcriptional regulator CWD84_06095 ENOG4108Z0Z intracellular protease Pfpi family CWD84_06105 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CWD84_06145 ENOG4105C26 Dehydrogenase CWD84_06150 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CWD84_06160 ENOG4105BZU Histidine kinase CWD84_06170 ENOG4105U5Y Transcriptional regulator CWD84_06195 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) CWD84_06205 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CWD84_06210 ENOG4105EFZ amidohydrolase CWD84_06215 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CWD84_06220 ENOG4105D07 Signal peptide peptidase, SppA CWD84_06225 ENOG4105VK3 rdd domain containing protein CWD84_06235 ENOG4105KBJ sporulation protein ytfj CWD84_06240 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CWD84_06250 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CWD84_06255 ENOG4105EPU Molybdenum cofactor synthesis domain protein CWD84_06260 ENOG4105CDH Citrulline--aspartate ligase CWD84_06265 ENOG4105CH7 arginosuccinase CWD84_06275 ENOG4105E8R UPF0173 metal-dependent hydrolase CWD84_06290 ENOG4105SFS phosphoesterase RecJ domain protein CWD84_06295 ENOG4106EVM CWD84_06305 ENOG4105VV2 CWD84_06310 ENOG4105C0B DNA polymerase III (alpha subunit) CWD84_06315 ENOG4105C6K Malic enzyme CWD84_06320 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) CWD84_06325 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) CWD84_06330 ENOG4105CTQ phosphohexokinase CWD84_06335 ENOG4105CA9 Pyruvate kinase CWD84_06340 ENOG4105FS0 cytoplasmic membrane protein CWD84_06345 ENOG4108REF Sporulation integral membrane protein ytvi CWD84_06355 ENOG4105BZN citrate synthase CWD84_06360 ENOG4108HMX isocitrate dehydrogenase (NADP) CWD84_06370 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CWD84_06375 ENOG4105BZU Histidine kinase CWD84_06380 ENOG4105C2M dna polymerase I CWD84_06385 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CWD84_06395 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CWD84_06400 ENOG4105CV8 reductase CWD84_06405 ENOG4105F27 Major Facilitator CWD84_06410 ENOG4105KVH Transcriptional regulator CWD84_06415 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CWD84_06420 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CWD84_06445 ENOG4108TDW sporulation protein YtxC CWD84_06450 ENOG4105C22 threonyL-tRNA synthetase CWD84_06455 ENOG4105U0R haloacid dehalogenase-like hydrolase CWD84_06460 ENOG4108HRK Histidine kinase CWD84_06465 ENOG4105DY9 regulatoR CWD84_06475 ENOG41067MG lrgb family CWD84_06480 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CWD84_06485 ENOG4105VJV 50s ribosomal protein L35 CWD84_06490 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CWD84_06495 ENOG410696E Membrane CWD84_06505 ENOG4105CN9 Peptidase m42 family protein CWD84_06520 ENOG4105EF1 ribulokinase CWD84_06525 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CWD84_06535 ENOG4108MDK Dehydrogenase CWD84_06550 ENOG4105DRS transport system, permease CWD84_06555 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CWD84_06565 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CWD84_06570 ENOG4105CQB FAD linked oxidase domain protein CWD84_06580 ENOG41067MF small acid-soluble spore protein CWD84_06585 ENOG4108RWN rrna methyltransferase CWD84_06590 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CWD84_06595 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CWD84_06600 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CWD84_06615 ENOG4105DCG PHP domain protein CWD84_06620 ENOG4105C98 muts2 protein CWD84_06635 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_06640 ENOG4107Z3H Transcriptional regulator, TetR family CWD84_06645 ENOG41060WC Enoyl-CoA hydratase CWD84_06650 ENOG4105BZJ Electron transfer flavoprotein CWD84_06655 ENOG4105C10 Electron transfer flavoprotein CWD84_06660 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CWD84_06665 ENOG4105K63 Thioredoxin CWD84_06670 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CWD84_06675 ENOG4105CFH Aspartokinase CWD84_06685 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CWD84_06695 ENOG4105E33 succinate dehydrogenase CWD84_06705 ENOG4105PFC Transcriptional regulator CWD84_06710 ENOG41067TZ transcriptional regulator, MarR family CWD84_06715 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CWD84_06720 ENOG4108XJQ germination protein CWD84_06725 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CWD84_06730 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CWD84_06735 ENOG4105M59 Phosphodiesterase, mj0936 family CWD84_06750 ENOG4107SCJ type I restriction enzyme EcoKI subunit R CWD84_06790 ENOG4105C7K acetolactate synthase CWD84_06795 ENOG4108ZP8 Acetolactate synthase small subunit CWD84_06800 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CWD84_06810 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CWD84_06815 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CWD84_06820 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CWD84_06830 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CWD84_06835 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CWD84_06840 ENOG4108IUQ atp-dependent protease CWD84_06845 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CWD84_06850 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CWD84_06860 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CWD84_06870 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CWD84_06880 ENOG4105D52 delta-aminolevulinic acid dehydratase CWD84_06885 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CWD84_06890 ENOG41068KH stage VI sporulation protein D CWD84_06895 ENOG4106AR7 Spore coat protein CWD84_06905 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CWD84_06910 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CWD84_06915 ENOG4106A3R peptidase CWD84_06925 ENOG4108Z03 MAF-like protein CWD84_06930 ENOG4105W5Q DNA repair protein (RadC CWD84_06935 ENOG4105DFF Rod shape-determining protein mreb CWD84_06940 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CWD84_06945 ENOG4105YHC Rod shape-determining protein MreD CWD84_06950 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CWD84_06955 ENOG4107QMS site-determining protein CWD84_06970 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CWD84_06975 ENOG4105X36 (ribosomal) protein CWD84_06980 ENOG4105K46 50S ribosomal protein l27 CWD84_06990 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CWD84_07000 ENOG4105CQC Prephenate dehydratase CWD84_07015 ENOG4108IYU L-aspartate oxidase CWD84_07020 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CWD84_07025 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CWD84_07030 ENOG4106678 morphogenetic protein associated with SpoVID CWD84_07045 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CWD84_07050 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CWD84_07055 ENOG41061AI Protein of unknown function (DUF2905) CWD84_07060 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CWD84_07065 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CWD84_07070 ENOG4105VIE preprotein translocase, subunit YajC CWD84_07075 ENOG4105NAP CWD84_07080 ENOG4108QG2 Membrane CWD84_07085 ENOG4105CKP Polysaccharide Biosynthesis Protein CWD84_07095 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CWD84_07100 ENOG4105NCW Trka-c domain protein CWD84_07105 ENOG41067VP Protein of unknown function (DUF1049) CWD84_07110 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CWD84_07120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CWD84_07125 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) CWD84_07130 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CWD84_07135 ENOG4105CUT histidyl-tRNA synthetase CWD84_07140 ENOG4105C9M aspartyl-trna synthetase CWD84_07150 ENOG4105CUZ uba thif-type nad fad binding protein CWD84_07155 ENOG4105D1H recombination factor protein RarA CWD84_07165 ENOG4105C3J Cysteine desulfurase CWD84_07170 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CWD84_07180 ENOG4105C7H Helicase, RecD TraA family CWD84_07190 ENOG41060CR CWD84_07200 ENOG4105DRP amino acid AbC transporter CWD84_07205 ENOG4105EAD ABC transporter CWD84_07210 ENOG4105CT1 (ABC) transporter CWD84_07215 ENOG4105CDA abc transporter atp-binding protein CWD84_07220 ENOG4105C02 permease CWD84_07225 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CWD84_07230 ENOG4105VBH UPF0297 protein CWD84_07235 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CWD84_07245 ENOG4105HHA aminodeoxychorismate lyase CWD84_07250 ENOG4108VQJ O-methyltransferase CWD84_07255 ENOG4105XYU peptidase (U32 family) CWD84_07260 ENOG4105CFP Peptidase U32 CWD84_07370 ENOG410682Q Phage transcriptional regulator, ArpU CWD84_07380 ENOG4105CNU cell division protein FtsK CWD84_07480 ENOG4108FKH Transglycosylase SLT domain CWD84_07490 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_07500 ENOG41068G1 CWD84_07520 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_07650 ENOG410682Q Phage transcriptional regulator, ArpU CWD84_07660 ENOG4105CNU cell division protein FtsK CWD84_07760 ENOG4108FKH Transglycosylase SLT domain CWD84_07770 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_07780 ENOG41068G1 CWD84_07800 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_07930 ENOG410682Q Phage transcriptional regulator, ArpU CWD84_07940 ENOG4105CNU cell division protein FtsK CWD84_08040 ENOG4108FKH Transglycosylase SLT domain CWD84_08050 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_08060 ENOG41068G1 CWD84_08080 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_08210 ENOG410682Q Phage transcriptional regulator, ArpU CWD84_08220 ENOG4105CNU cell division protein FtsK CWD84_08320 ENOG4108FKH Transglycosylase SLT domain CWD84_08330 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_08340 ENOG41068G1 CWD84_08360 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_08490 ENOG410682Q Phage transcriptional regulator, ArpU CWD84_08500 ENOG4105CNU cell division protein FtsK CWD84_08600 ENOG4108FKH Transglycosylase SLT domain CWD84_08610 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_08620 ENOG41068G1 CWD84_08640 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_08670 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CWD84_08675 ENOG4107XRG penicillin-binding protein CWD84_08705 ENOG4105C28 cystathionine CWD84_08720 ENOG4108JB9 formate dehydrogenase CWD84_08725 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CWD84_08730 ENOG4105TMB Formate nitrite transporter CWD84_08750 ENOG41082JN Transcriptional regulator CWD84_08755 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CWD84_08760 ENOG4105D94 Major Facilitator Superfamily CWD84_08765 ENOG4108Z66 YbaK ebsC protein CWD84_08780 ENOG4108HCJ Hydrolase CWD84_08805 ENOG4108J8C transporter major facilitator family protein CWD84_08815 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CWD84_08825 ENOG41086D8 Transcriptional regulator CWD84_08895 ENOG4107EXU Short-chain dehydrogenase reductase Sdr CWD84_08900 ENOG4105CSC Glucose uptake protein CWD84_08910 ENOG4105KVH Transcriptional regulator CWD84_08915 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWD84_08930 ENOG41080BT SNARE associated Golgi CWD84_08955 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CWD84_08960 ENOG4105CQW ribosome biogenesis GTPase YqeH CWD84_08965 ENOG4105E2X shikimate dehydrogenase CWD84_08970 ENOG410812S Rna-binding protein CWD84_08975 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CWD84_08980 ENOG4108WF2 Metal Dependent Phosphohydrolase CWD84_08990 ENOG4108D32 Methyltransferase CWD84_09000 ENOG4105KQC Competence protein CWD84_09005 ENOG4108UK2 deaminase CWD84_09010 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CWD84_09020 ENOG4105TQK DNA polymerase iii, delta' subunit CWD84_09025 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) CWD84_09030 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) CWD84_09035 ENOG4108ZRV stage ii sporulation protein p CWD84_09045 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CWD84_09050 ENOG4105CSA Coproporphyrinogen iii oxidase CWD84_09055 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CWD84_09060 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CWD84_09065 ENOG4105CFG Acts as a chaperone (By similarity) CWD84_09070 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) CWD84_09075 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CWD84_09080 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CWD84_09085 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CWD84_09100 ENOG4105KTH gatB Yqey CWD84_09105 ENOG4105F7J membrane-bound serine protease CWD84_09110 ENOG4105DI5 UPF0365 protein CWD84_09120 ENOG41068P3 sporulation protein YqfC CWD84_09125 ENOG4105EI1 sporulation protein yqfd CWD84_09130 ENOG4105C9A Phoh family CWD84_09135 ENOG4105CTJ Metal Dependent Phosphohydrolase CWD84_09140 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CWD84_09145 ENOG4107YR5 Diacylglycerol kinase CWD84_09150 ENOG4105KG3 cytidine deaminase CWD84_09155 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CWD84_09165 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CWD84_09170 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CWD84_09175 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CWD84_09185 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CWD84_09190 ENOG4108UPT UPF0178 protein CWD84_09195 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CWD84_09200 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWD84_09215 ENOG4105EGD dinuclear metal center protein, YbgI family CWD84_09220 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CWD84_09235 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CWD84_09240 ENOG41069ZM Protein of unknown function (DUF2624) CWD84_09245 ENOG4108JYZ YitT family CWD84_09250 ENOG4105N80 Ferric uptake regulator, Fur family CWD84_09255 ENOG4108U5J '-nucleotidase CWD84_09260 ENOG41063Y9 CWD84_09265 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CWD84_09280 ENOG4105SXS Protein of unknown function (DUF456) CWD84_09285 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CWD84_09295 ENOG4107RF6 penicillin-binding protein CWD84_09300 ENOG4105CVA phosphate CWD84_09305 ENOG4105C8U phosphate abc transporter CWD84_09310 ENOG4105E2Z phosphate ABC transporter (Permease CWD84_09315 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CWD84_09320 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CWD84_09325 ENOG41068DG YceG-like family CWD84_09335 ENOG4105WDJ 50S ribosomal protein L33 CWD84_09340 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CWD84_09385 ENOG4105C5X domain protein CWD84_09410 ENOG4105C37 (CBS) domain CWD84_09470 ENOG4105VFR signal peptidase CWD84_09480 ENOG4108IMY Transcriptional regulator CWD84_09495 ENOG4105C0D helicase CWD84_09500 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CWD84_09510 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CWD84_09515 ENOG4105WZW rhodanese family CWD84_09520 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CWD84_09540 ENOG4105CBJ Metal-dependent enzyme CWD84_09550 ENOG4105DC7 peptidase M24 CWD84_09555 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CWD84_09565 ENOG4105CD2 stage iii sporulation protein aa CWD84_09570 ENOG4105KR5 Stage iii sporulation protein CWD84_09575 ENOG4108CQH stage III sporulation protein AC CWD84_09580 ENOG4105KQ4 Stage iii sporulation protein ad CWD84_09590 ENOG410644B Stage III sporulation protein af CWD84_09610 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CWD84_09615 ENOG4108ZSR alkaline shock protein CWD84_09620 ENOG4105M7K Involved in the transcription termination process (By similarity) CWD84_09625 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CWD84_09630 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CWD84_09635 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CWD84_09640 ENOG4105CTB Polyprenyl synthetase CWD84_09645 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) CWD84_09650 ENOG4105DX0 Hemolysin A CWD84_09655 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CWD84_09660 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CWD84_09665 ENOG4105S1Z Stage IV sporulation protein B CWD84_09670 ENOG4107QQR Sporulation CWD84_09680 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CWD84_09695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CWD84_09715 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CWD84_09720 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CWD84_09730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CWD84_09735 ENOG4105C1G acyl-Coa dehydrogenase CWD84_09745 ENOG4105DXD 2-methylcitrate dehydratase CWD84_09750 ENOG4105CR4 methylisocitrate lyase CWD84_09755 ENOG4106CCJ Protein of unknown function (DUF2627) CWD84_09760 ENOG4108JUB Transcriptional regulator CWD84_09770 ENOG4107RDP Dehydrogenase CWD84_09775 ENOG4105CKM Branched-chain carboxylic acid kinase CWD84_09790 ENOG4105CPP Dehydrogenase, E1 component CWD84_09795 ENOG4105C7S Dehydrogenase CWD84_09800 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CWD84_09805 ENOG4108Y6J UPF0403 protein CWD84_09810 ENOG4108HW3 (ABC) transporter CWD84_09815 ENOG4105E5Q amino acid AbC transporter CWD84_09820 ENOG4105CDA abc transporter atp-binding protein CWD84_09825 ENOG4108QEG Membrane CWD84_09830 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CWD84_09835 ENOG4108ZVT methylmalonyl-coA epimerase CWD84_09840 ENOG4108HNZ carboxyl transferase CWD84_09845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CWD84_09850 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) CWD84_09860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CWD84_09865 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CWD84_09870 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CWD84_09875 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CWD84_09880 ENOG410861F 50S ribosomal protein L33 CWD84_09890 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CWD84_09900 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CWD84_09910 ENOG4107QKG PfaD family CWD84_09925 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_09930 ENOG4105CHR reductase CWD84_09940 ENOG4105C0W non-ribosomal peptide synthetase CWD84_09950 ENOG4105C0W non-ribosomal peptide synthetase CWD84_09955 ENOG4105C0W non-ribosomal peptide synthetase CWD84_09970 ENOG4106A3M Cytochrome p-450 CWD84_09975 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CWD84_09980 ENOG4108KQ6 Enoyl-CoA hydratase CWD84_09985 ENOG4105II7 pyrroline-5-carboxylate reductase CWD84_09990 ENOG41069FQ Metallo-beta-lactamase superfamily CWD84_09995 ENOG4108IXY short-chain dehydrogenase reductase CWD84_10005 ENOG4105CS9 pantothenic acid kinase CWD84_10010 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase CWD84_10020 ENOG4105C02 permease CWD84_10035 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CWD84_10040 ENOG4108XET gCN5-related N-acetyltransferase CWD84_10045 ENOG4105KAC Antibiotic biosynthesis monooxygenase CWD84_10050 ENOG4105RHY Pfam:UPF0157 CWD84_10055 ENOG4106HZJ CWD84_10075 ENOG4105CPC Aldo Keto reductase CWD84_10085 ENOG4108YZ4 nudix hydrolase CWD84_10095 ENOG4108IMY Transcriptional regulator CWD84_10100 ENOG4105HDK L-asparaginase CWD84_10105 ENOG4108IJ0 Aspartate ammonia-lyase CWD84_10110 ENOG4105DFD Na H antiporter CWD84_10130 ENOG4105MZ9 stage II sporulation protein m CWD84_10135 ENOG4105I3K Ferric uptake regulator, Fur family CWD84_10145 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CWD84_10150 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CWD84_10155 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CWD84_10160 ENOG4105DZ1 carboxypeptidase CWD84_10165 ENOG41082AN stage II sporulation protein CWD84_10170 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CWD84_10175 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWD84_10190 ENOG41090VF Stage v sporulation protein ac CWD84_10195 ENOG4105CZ3 stage V sporulation protein ad CWD84_10205 ENOG4105G6R Stage v sporulation protein ae CWD84_10215 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CWD84_10220 ENOG4105PTM secreted protein CWD84_10225 ENOG4107ZE5 PPIases accelerate the folding of proteins CWD84_10250 ENOG4108R6K riboflavin synthase, subunit alpha CWD84_10255 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CWD84_10260 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CWD84_10285 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CWD84_10290 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CWD84_10300 ENOG4105DZ1 carboxypeptidase CWD84_10305 ENOG4108JIC nucleoside recognition domain protein CWD84_10315 ENOG4105FE9 pseudouridine synthase CWD84_10325 ENOG4107TWT Cytochrome c biogenesis protein CWD84_10330 ENOG4105CRE cytochrome C CWD84_10335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CWD84_10340 ENOG4105BZU Histidine kinase CWD84_10355 ENOG4108JQ1 Dehydrogenase CWD84_10360 ENOG4108SAX Membrane CWD84_10370 ENOG4105T7X CWD84_10375 ENOG4105C9U ATP-dependent DNA helicase RecQ CWD84_10380 ENOG4105I7S Abortive infection protein CWD84_10395 ENOG4107RGJ metallophosphoesterase CWD84_10410 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CWD84_10415 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CWD84_10425 ENOG4105MSI germination protein ypeb CWD84_10435 ENOG4105CAT Cytidine monophosphate kinase CWD84_10440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CWD84_10460 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CWD84_10465 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CWD84_10480 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CWD84_10485 ENOG4105K70 DNA-binding protein CWD84_10490 ENOG4105EUJ GTP cyclohydrolase i CWD84_10495 ENOG4105WP2 Tryptophan RNA-binding attenuator protein CWD84_10500 ENOG4105XXQ heptaprenyl diphosphate synthase component I CWD84_10505 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CWD84_10510 ENOG4105EAH synthase CWD84_10515 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CWD84_10520 ENOG4105BZU Histidine kinase CWD84_10525 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CWD84_10535 ENOG4105KHN chorismate mutase CWD84_10540 ENOG4105CRQ synthase (Component I) CWD84_10550 ENOG4105DK0 Indole-3-glycerol phosphate synthase CWD84_10555 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CWD84_10560 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CWD84_10570 ENOG4105CIH Imidazole acetol-phosphate transaminase CWD84_10580 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CWD84_10585 ENOG41068YB TPR repeat-containing protein CWD84_10605 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CWD84_10625 ENOG4105F0F Oxalate decarboxylase CWD84_10630 ENOG4108JYZ YitT family CWD84_10635 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CWD84_10640 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CWD84_10645 ENOG4108Z5K methylglyoxal synthase CWD84_10650 ENOG4105FJR Lmbe family CWD84_10655 ENOG4105CPK Glycosyl transferase (Group 1 CWD84_10660 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CWD84_10665 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CWD84_10670 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CWD84_10680 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CWD84_10685 ENOG4105DVT helicase CWD84_10690 ENOG4105YAC CWD84_10700 ENOG4105CHM Aminotransferase CWD84_10705 ENOG4105C5S asparaginyl-tRNA synthetase CWD84_10715 ENOG4105CSM endonuclease III CWD84_10725 ENOG4105BZ4 penicillin-binding protein CWD84_10730 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) CWD84_10775 ENOG4108I5C dEAD DEAH box helicase CWD84_10780 ENOG4107X2U Inherit from COG: Exonuclease-like protein CWD84_10790 ENOG4108UKS UPF0398 protein CWD84_10795 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) CWD84_10805 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CWD84_10820 ENOG4105DVT helicase CWD84_10825 ENOG4105CTD carboxy-peptidase CWD84_10830 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CWD84_10835 ENOG4105C2W permease CWD84_10870 ENOG41065KQ synthase CWD84_10885 ENOG410890F Dynamin family CWD84_10910 ENOG41081VK Ribonuclease CWD84_10950 ENOG4105CVG Homoserine O-transsuccinylase CWD84_10955 ENOG4108V06 Glutathione peroxidase CWD84_10970 ENOG4105C01 Dihydroxy-acid dehydratase CWD84_10975 ENOG4108Y6J UPF0403 protein CWD84_10980 ENOG4107YX5 Pfam:DUF548 CWD84_10990 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CWD84_10995 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CWD84_11005 ENOG4108UT2 hemolysin iii CWD84_11015 ENOG4105C7B Threonine dehydratase CWD84_11025 ENOG4108KF3 Electron transport protein SCO1 SenC CWD84_11030 ENOG41090WU lipolytic protein G-D-S-L family CWD84_11035 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) CWD84_11045 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CWD84_11050 ENOG4105E0X reductase CWD84_11055 ENOG4105C5E polysaccharide biosynthesis protein CWD84_11090 ENOG4106BHF CWD84_11095 ENOG4106ANW SMI1_KNR4 CWD84_11130 ENOG410780I phosphoprotein phosphatase activity CWD84_11170 ENOG41080V3 Major Facilitator superfamily CWD84_11220 ENOG4105FTQ Dna gyrase CWD84_11225 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CWD84_11240 ENOG4107S4Y M20 DapE family protein YgeY CWD84_11245 ENOG4108TSC N-acetyltransferase CWD84_11250 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CWD84_11275 ENOG410841Q phosphoesterase PA-phosphatase related protein CWD84_11280 ENOG4106Z5R CWD84_11290 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CWD84_11295 ENOG4108VXD carboxy-peptidase CWD84_11315 ENOG4108S3Y transcriptional regulator CWD84_11320 ENOG4105CS2 ec 3.2.1.21 CWD84_11330 ENOG4105E1V na solute symporter CWD84_11345 ENOG4105FBA Phospholipase Carboxylesterase CWD84_11390 ENOG4106SCS STAS domain CWD84_11395 ENOG4107QMU Mate efflux family protein CWD84_11405 ENOG41087PP glycosyltransferase MGT family CWD84_11410 ENOG4105K4H Nlp p60 protein CWD84_11420 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CWD84_11425 ENOG4107T89 von Willebrand factor, type A CWD84_11430 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CWD84_11435 ENOG4105C7S Dehydrogenase CWD84_11445 ENOG4105C09 Bile acid CWD84_11450 ENOG4105C8J )-transporter CWD84_11455 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CWD84_11460 ENOG4105EWU Squalene--hopene cyclase CWD84_11465 ENOG4105C26 Dehydrogenase CWD84_11510 ENOG4105SCY DNAK suppressor CWD84_11515 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CWD84_11525 ENOG4105C9U ATP-dependent DNA helicase RecQ CWD84_11530 ENOG41069ER domain protein CWD84_11555 ENOG4108SJC Membrane CWD84_11565 ENOG4105KTU Transcriptional regulator, arsr family CWD84_11575 ENOG4108W8B Beta-lactamase domain protein CWD84_11585 ENOG4105FTV AraC Family Transcriptional Regulator CWD84_11590 ENOG4108Z7R Chaperone CsaA CWD84_11595 ENOG4106BHF CWD84_11600 ENOG4106ANW SMI1_KNR4 CWD84_11625 ENOG4108J2R molybdopterin oxidoreductase CWD84_11630 ENOG4108M3J Dehydrogenase CWD84_11640 ENOG4105IE8 Alpha-ketoglutarate permease CWD84_11645 ENOG4108UB7 CWD84_11670 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CWD84_11675 ENOG4105C5Q Transcriptional regulator CWD84_11680 ENOG4105CBC glutamate synthase CWD84_11685 ENOG4105BZ8 glutamate synthase CWD84_11695 ENOG4105CB2 alcohol dehydrogenase CWD84_11700 ENOG4108KSA LysR family transcriptional regulator CWD84_11705 ENOG4105C22 threonyL-tRNA synthetase CWD84_11710 ENOG4105WAB arsR family transcriptional regulator CWD84_11715 ENOG4108RWP Major Facilitator Superfamily protein CWD84_11720 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CWD84_11745 ENOG4107QJQ Mate efflux family protein CWD84_11750 ENOG4108N2V aldose 1-epimerase CWD84_11755 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CWD84_11765 ENOG4105C0W non-ribosomal peptide synthetase CWD84_11775 ENOG4105C0W non-ribosomal peptide synthetase CWD84_11780 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_11790 ENOG4106U2H Protein of unknown function (DUF1360) CWD84_11795 ENOG4105F32 YngK protein CWD84_11800 ENOG4105C1G acyl-Coa dehydrogenase CWD84_11805 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_11810 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CWD84_11815 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CWD84_11820 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CWD84_11825 ENOG4105E39 Enoyl-CoA hydratase CWD84_11830 ENOG4107QX3 carboxylase CWD84_11835 ENOG4107T5V SNARE associated Golgi CWD84_11840 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CWD84_11855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CWD84_11860 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CWD84_11865 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) CWD84_11870 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CWD84_11875 ENOG4106A3M Cytochrome p-450 CWD84_11880 ENOG4105CY2 Citrate transporter CWD84_11885 ENOG4105D6N CoA-transferase, subunit a CWD84_11890 ENOG4108IIH CoA-transferase subunit B CWD84_11895 ENOG4105DTD Dehydrogenase CWD84_11920 ENOG4107SYN Glycosyl hydrolases family 43 CWD84_11980 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWD84_11985 ENOG4105K4P CoA-binding domain protein CWD84_11990 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CWD84_11995 ENOG4105W8X HesB YadR YfhF-family protein CWD84_12000 ENOG4105MI2 CWD84_12010 ENOG41067CD Small, acid-soluble spore protein Tlp CWD84_12025 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CWD84_12030 ENOG4108I0Z Aconitate hydratase CWD84_12065 ENOG4107QIV Cytochrome c biogenesis protein CWD84_12075 ENOG4105VXM UPF0154 protein CWD84_12085 ENOG4105CV1 Transketolase (EC 2.2.1.1) CWD84_12090 ENOG4105VPS UPF0291 protein CWD84_12095 ENOG4108SVB resolvase CWD84_12105 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CWD84_12130 ENOG4105K7W phage-related replication protein CWD84_12135 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CWD84_12165 ENOG4108M1A Chitin-binding protein CWD84_12185 ENOG4105EPI acetyltransferase, (GNAT) family CWD84_12205 ENOG4105MXK Carbon dioxide concentrating mechanism protein CWD84_12210 ENOG4105DQ4 alcohol dehydrogenase CWD84_12215 ENOG4105SF0 DinB family CWD84_12220 ENOG4105D29 Helix-turn-helix type 11 domain protein CWD84_12235 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CWD84_12240 ENOG4105CMG Carbohydrate kinase CWD84_12245 ENOG4105C93 Xylose Isomerase CWD84_12255 ENOG4105DSG hydrolase family 43 CWD84_12260 ENOG4105CT4 transporter CWD84_12315 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_12340 ENOG41068G1 CWD84_12350 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CWD84_12360 ENOG4108FKH Transglycosylase SLT domain CWD84_12510 ENOG4108ZUE Phage regulatory protein rha CWD84_12520 ENOG4108IMY Transcriptional regulator CWD84_12530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CWD84_12535 ENOG4105C5F glutamine synthetase CWD84_12540 ENOG4105KV4 Transcriptional regulator CWD84_12545 ENOG4105CXI aluminum resistance protein CWD84_12550 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CWD84_12555 ENOG4106F1P AAA ATPase, central domain protein CWD84_12565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CWD84_12570 ENOG4105U6W MutT NUDIX family protein CWD84_12575 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CWD84_12580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CWD84_12605 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CWD84_12630 ENOG4108X3M OsmC Ohr family protein CWD84_12635 ENOG4105K7W phage-related replication protein CWD84_12645 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CWD84_12660 ENOG4105XPP Protein of unknown function (DUF1275) CWD84_12665 ENOG4105WFK nuclease CWD84_12670 ENOG4106A3M Cytochrome p-450 CWD84_12680 ENOG4105C0W non-ribosomal peptide synthetase CWD84_12690 ENOG4107SQU synthase CWD84_12695 ENOG4105C0W non-ribosomal peptide synthetase CWD84_12700 ENOG4108KQ6 Enoyl-CoA hydratase CWD84_12705 ENOG4108MGH Enoyl-CoA hydratase CWD84_12710 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CWD84_12715 ENOG41062T2 Acyl carrier protein CWD84_12725 ENOG4108JA1 polyketide synthase CWD84_12730 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CWD84_12735 ENOG4108151 Beta-lactamase domain protein CWD84_12780 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CWD84_12800 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CWD84_12805 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CWD84_12810 ENOG4105CPQ Dehydrogenase CWD84_12815 ENOG4105MCT stage V sporulation protein S CWD84_12820 ENOG4105D48 metallophosphoesterase CWD84_12830 ENOG4108A04 Beta-lactamase CWD84_12835 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) CWD84_12840 ENOG4105CEV competence damage-inducible protein CWD84_12845 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CWD84_12860 ENOG4105XZV Protein of unknown function (DUF3243) CWD84_12865 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CWD84_12880 ENOG4105EYF MMPL domain protein CWD84_12895 ENOG4105FDP GntR family transcriptional regulator CWD84_12900 ENOG4105CNU cell division protein FtsK CWD84_12910 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CWD84_12920 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CWD84_12930 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CWD84_12935 ENOG4108S0H Dipicolinic acid synthetase, b subunit CWD84_12940 ENOG4105E35 Dipicolinate synthase subunit A CWD84_12950 ENOG4105C1V Peptidase, M16 CWD84_12960 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CWD84_12965 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CWD84_12970 ENOG4105DTN riboflavin biosynthesis protein ribF CWD84_12975 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CWD84_12980 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CWD84_12985 ENOG4105W7A Protein of unknown function (DUF503) CWD84_12990 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CWD84_12995 ENOG4105VHM ribosomal protein CWD84_13000 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CWD84_13005 ENOG4105CHV Transcription elongation factor NusA CWD84_13010 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CWD84_13015 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CWD84_13020 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CWD84_13025 ENOG4105DZP Membrane-associated zinc metalloprotease CWD84_13035 ENOG4105KNE Phosphatidate cytidylyltransferase CWD84_13040 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CWD84_13045 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CWD84_13050 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) CWD84_13060 ENOG4105CE9 30S ribosomal protein S2 CWD84_13070 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWD84_13075 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) CWD84_13085 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CWD84_13090 ENOG4105CBS Chea signal transduction histidine kinase CWD84_13095 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CWD84_13105 ENOG4105FZW flagellar biosynthesis regulator FlhF CWD84_13110 ENOG4105D7B Flagellar biosynthesis protein flha CWD84_13115 ENOG4105D00 flagellar biosynthetic protein flhB CWD84_13120 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CWD84_13125 ENOG4105VS8 Flagellar biosynthetic protein fliq CWD84_13130 ENOG4105CN7 Flagellar biosynthetic protein FliP CWD84_13140 ENOG4107YTP response regulator receiver protein CWD84_13145 ENOG4105DD5 Flagellar motor switch protein CWD84_13150 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CWD84_13160 ENOG41068WV flagellar FlbD family protein CWD84_13165 ENOG4108JQA flagellar CWD84_13170 ENOG410822I Flagellar hook capping protein CWD84_13175 ENOG410696Y Flagellar hook-length control protein CWD84_13185 ENOG4106YF4 Flagellar biosynthesis chaperone CWD84_13200 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CWD84_13205 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CWD84_13210 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CWD84_13215 ENOG4108ZC9 flagellar basal-body rod protein flgc CWD84_13220 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CWD84_13230 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CWD84_13235 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CWD84_13240 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CWD84_13245 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CWD84_13250 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CWD84_13255 ENOG4105C79 DNA protecting protein DprA CWD84_13260 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CWD84_13265 ENOG4105CMV Succinyl-CoA synthetase subunit beta CWD84_13270 ENOG4105VM1 flagellar CWD84_13280 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CWD84_13285 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CWD84_13290 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CWD84_13295 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CWD84_13310 ENOG4108BW8 UPF0109 protein CWD84_13315 ENOG4105K5M 30s ribosomal protein S16 CWD84_13325 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CWD84_13335 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CWD84_13340 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CWD84_13345 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CWD84_13350 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CWD84_13355 ENOG4105CHR reductase CWD84_13360 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CWD84_13365 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) CWD84_13370 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CWD84_13375 ENOG4105CB5 ATP-dependent DNA helicase recG CWD84_13380 ENOG4105EJQ L-serine dehydratase CWD84_13390 ENOG4105DP4 dak2 domain fusion protein ylov CWD84_13395 ENOG4108ZAA Alkaline-shock protein CWD84_13400 ENOG4105VB9 50S ribosomal protein l28 CWD84_13410 ENOG4105FJ0 thiamine CWD84_13415 ENOG4105DJV ribulose-phosphate 3-epimerase CWD84_13420 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CWD84_13425 ENOG4105D9P serine threonine protein kinase CWD84_13430 ENOG4108ZF3 Phosphatase CWD84_13435 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CWD84_13440 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CWD84_13445 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CWD84_13450 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CWD84_13455 ENOG4105C25 Primosomal protein n' CWD84_13460 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CWD84_13470 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CWD84_13475 ENOG4105KC4 UPF0296 protein CWD84_13480 ENOG4105DSJ YicC domain protein CWD84_13490 ENOG4105F23 Fibronectin-binding protein CWD84_13500 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CWD84_13505 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CWD84_13510 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CWD84_13520 ENOG4107RIQ Sulfate adenylate transferase CWD84_13535 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CWD84_13540 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CWD84_13545 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CWD84_13550 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CWD84_13555 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CWD84_13560 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CWD84_13570 ENOG4105CXT aspartate transcarbamylase CWD84_13580 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CWD84_13585 ENOG4105C34 Pseudouridine synthase CWD84_13590 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CWD84_13600 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CWD84_13615 ENOG4105DBK s4 domain protein CWD84_13620 ENOG41067XK integral membrane protein CWD84_13625 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CWD84_13630 ENOG4105DFA alanine racemase domain protein CWD84_13635 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CWD84_13640 ENOG4105WR5 sporulation protein, YlmC YmxH family CWD84_13650 ENOG4105DKW ABC transporter CWD84_13660 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CWD84_13665 ENOG4105FFI sigma-e processing peptidase spoiiga CWD84_13675 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CWD84_13680 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CWD84_13685 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CWD84_13690 ENOG4105D4A Cell wall formation (By similarity) CWD84_13695 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CWD84_13700 ENOG4105CNI cell division protein FtsW CWD84_13705 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CWD84_13710 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CWD84_13715 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CWD84_13720 ENOG4105CJN penicillin-binding protein CWD84_13725 ENOG4105CJN penicillin-binding protein CWD84_13735 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CWD84_13740 ENOG4108V6E Cell division protein mraZ CWD84_13765 ENOG41067VY 50S ribosomal protein L32 CWD84_13770 ENOG4105KNH Nucleic acid-binding protein CWD84_13775 ENOG4105CDE UPF0348 protein CWD84_13780 ENOG41063PX domain protein CWD84_13785 ENOG4105D78 K07001 NTE family protein CWD84_13790 ENOG4105H20 Sporulation integral membrane protein YlbJ CWD84_13795 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CWD84_13800 ENOG4106H78 methyltransferase CWD84_13825 ENOG4106UY4 Inherit from COG: Scp-like extracellular CWD84_13830 ENOG41080XQ Signal transduction protein with cbs domains CWD84_13845 ENOG41064X9 cytochrome C oxidase subunit IV CWD84_13850 ENOG4105CCU oxidase (Subunit III) CWD84_13855 ENOG4105BZ9 Cytochrome C oxidase, subunit I CWD84_13865 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CWD84_13875 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CWD84_13880 ENOG4105CNI cell division protein FtsW CWD84_13890 ENOG4105CSV Glutaminase CWD84_13900 ENOG4108IAB Phoh family CWD84_13915 ENOG4105QA2 CWD84_13920 ENOG4105CI3 gtp-binding protein typa CWD84_13960 ENOG4105D4Y metalloprotease CWD84_13970 ENOG4105ECY inositol monophosphatase CWD84_13990 ENOG4105WBI UPF0223 protein CWD84_13995 ENOG4105CXN decarboxylase CWD84_14015 ENOG4107QN2 dihydrolipoyl dehydrogenase CWD84_14020 ENOG4105C7S Dehydrogenase CWD84_14025 ENOG4105CPP Dehydrogenase, E1 component CWD84_14035 ENOG4105FQP Beta-lactamase CWD84_14040 ENOG4105C0W non-ribosomal peptide synthetase CWD84_14045 ENOG4107SQU synthase CWD84_14050 ENOG4107SQU synthase CWD84_14055 ENOG4105C0W non-ribosomal peptide synthetase CWD84_14060 ENOG4105C0W non-ribosomal peptide synthetase CWD84_14065 ENOG4107SQU synthase CWD84_14070 ENOG4105C0W non-ribosomal peptide synthetase CWD84_14075 ENOG4107QKG PfaD family CWD84_14095 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CWD84_14100 ENOG4108X4Q Hydrolase CWD84_14105 ENOG4106148 UPF0356 protein CWD84_14110 ENOG4105CN5 Metallo-Beta-Lactamase CWD84_14115 ENOG4105CPN adenine deaminase CWD84_14120 ENOG4107ZYR domain protein CWD84_14130 ENOG4105BZU Histidine kinase CWD84_14160 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CWD84_14165 ENOG4105C5H ABC transporter CWD84_14180 ENOG4105DM4 PTS System CWD84_14185 ENOG4105DE4 1-phosphofructokinase CWD84_14190 ENOG4105E98 transcriptional regulator DeoR family CWD84_14195 ENOG4107RBB ABC transporter, permease CWD84_14200 ENOG4105C19 ABC transporter CWD84_14205 ENOG4107X8C Efflux transporter RND family MFP subunit CWD84_14215 ENOG41067WU Molybdopterin converting factor (Subunit 1) CWD84_14220 ENOG4108ZAF Molybdopterin CWD84_14225 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CWD84_14230 ENOG4105CVM Molybdenum cofactor synthesis domain protein CWD84_14235 ENOG4105D06 uba thif-type nad fad binding protein CWD84_14240 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CWD84_14255 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CWD84_14260 ENOG4105D8X mechanosensitive ion channel CWD84_14280 ENOG4105NQC Flavodoxin CWD84_14310 ENOG4108XRC Protein of unknown function (DUF458) CWD84_14315 ENOG4107IN1 Protein of unknown function (DUF1797) CWD84_14325 ENOG4105EPM Diguanylate phosphodiesterase CWD84_14335 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CWD84_14345 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CWD84_14355 ENOG4105UIN CWD84_14360 ENOG4107R88 Chemotaxis protein (CheV) CWD84_14365 ENOG4105CHM Aminotransferase CWD84_14370 ENOG4105BZU Histidine kinase CWD84_14380 ENOG4105K4I Scp-like extracellular CWD84_14390 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CWD84_14395 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CWD84_14400 ENOG4105F6S Spore photoproduct lyase CWD84_14410 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CWD84_14415 ENOG4105KRI phosphocarrier protein (HPr CWD84_14425 ENOG4105CID antiterminator CWD84_14435 ENOG4105DC7 peptidase M24 CWD84_14440 ENOG4105C59 p-type ATPase CWD84_14455 ENOG4105F0V Cell wall hydrolase CWD84_14480 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CWD84_14490 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CWD84_14495 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CWD84_14500 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CWD84_14505 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CWD84_14515 ENOG4108K88 Membrane CWD84_14525 ENOG4105E14 MotA TolQ exbB proton channel CWD84_14530 ENOG4105ER2 Ompa motb domain protein CWD84_14535 ENOG41090MY MarR family Transcriptional regulator CWD84_14540 ENOG4105BZU Histidine kinase CWD84_14550 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CWD84_14555 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CWD84_14560 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CWD84_14565 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate CWD84_14575 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CWD84_14585 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CWD84_14590 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CWD84_14595 ENOG4105BZU Histidine kinase CWD84_14600 ENOG4108TGC Acyltransferase CWD84_14610 ENOG410900G Protein of unknown function (DUF421) CWD84_14620 ENOG4105D0M Protease HtpX homolog CWD84_14630 ENOG410681C small acid-soluble spore protein CWD84_14640 ENOG4108WZW RNA polymerase sigma CWD84_14645 ENOG4107TS3 membrane protein, TerC CWD84_14650 ENOG4107T5V SNARE associated Golgi CWD84_14655 ENOG4105BZU Histidine kinase CWD84_14660 ENOG4105FDF Could be involved in DNA repair (By similarity) CWD84_14665 ENOG4105DQE DNA ligase CWD84_14690 ENOG4105V75 Transcriptional regulator CWD84_14695 ENOG4105CJW magnesium transporter CWD84_14700 ENOG4105VRS hydrolase family 18 CWD84_14705 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CWD84_14710 ENOG4108JJB ABC transporter CWD84_14715 ENOG4108W7F transporter, permease CWD84_14725 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CWD84_14730 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CWD84_14740 ENOG4105D8G Major Facilitator superfamily CWD84_14745 ENOG4107Y2X deaminase CWD84_14755 ENOG4107TVC Glycosyl transferase, family 2 CWD84_14770 ENOG4108ZHJ Organic hydroperoxide resistance protein CWD84_14775 ENOG4105K56 Transcriptional regulator CWD84_14790 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CWD84_14795 ENOG4105CIY formyltetrahydrofolate deformylase CWD84_14800 ENOG41080TC multidrug resistance protein CWD84_14810 ENOG4108428 Inherit from COG: -acetyltransferase CWD84_14815 ENOG4108S4H thioesterase Superfamily protein CWD84_14820 ENOG4107TUM Amidinotransferase CWD84_14825 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CWD84_14830 ENOG4108JQ7 (ABC) transporter CWD84_14835 ENOG4107SN7 NLP P60 protein CWD84_14840 ENOG4105DTQ mandelate racemase muconate lactonizing CWD84_14845 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CWD84_14855 ENOG4105C3U ABC transporter CWD84_14860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CWD84_14865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CWD84_14870 ENOG4108ME1 Peptidase M55 D-aminopeptidase CWD84_14880 ENOG4105C0H protease CWD84_14885 ENOG4105CKK Glycosyl transferase, family 2 CWD84_14890 ENOG4105EDW glycosyl transferase, family 39 CWD84_14900 ENOG4107R7I amino acid CWD84_14905 ENOG4107GRR phosphate transport regulator CWD84_14910 ENOG4105CJ3 phosphate transporter CWD84_14925 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CWD84_14955 ENOG41068G1 CWD84_14965 ENOG410906S phage-like element pbsx protein xkdt CWD84_14970 ENOG41066EA baseplate J family protein CWD84_14975 ENOG4105MFU Protein of unknown function (DUF2634) CWD84_14985 ENOG4105X7F CWD84_14990 ENOG4108WZM domain protein CWD84_14995 ENOG4108FKH Transglycosylase SLT domain CWD84_14995 ENOG4108FKH Transglycosylase SLT domain CWD84_14995 ENOG4108FKH Transglycosylase SLT domain CWD84_15005 ENOG4105MTC XkdN-like protein CWD84_15010 ENOG4105FR7 XkdM protein, phage-like element PBSX CWD84_15015 ENOG4105PQS phage protein CWD84_15030 ENOG41060SN CWD84_15055 ENOG4108MDF Phage Portal Protein CWD84_15060 ENOG4105IG6 Phage terminase, large subunit CWD84_15065 ENOG4108TFU terminase (Small subunit) CWD84_15105 ENOG410635T phage-like element pbsx protein CWD84_15110 ENOG4105K7W phage-related replication protein CWD84_15115 ENOG4105KWG Pfam:DUF1696 CWD84_15135 ENOG4107TSN permease CWD84_15145 ENOG4107KJX Transcriptional regulator CWD84_15165 ENOG4105Q95 Cupin 2, conserved barrel domain protein CWD84_15175 ENOG4108IXI (ABC) transporter CWD84_15180 ENOG4105C4B ABC transporter, permease CWD84_15185 ENOG4105EXQ uroporphyrinogen iii synthase hem4 CWD84_15195 ENOG41087PP glycosyltransferase MGT family CWD84_15200 ENOG4106A3M Cytochrome p-450 CWD84_15210 ENOG4108IEG Formate dehydrogenase Alpha subunit CWD84_15230 ENOG4105KT7 mgtC SapB transporter CWD84_15250 ENOG4105E98 transcriptional regulator DeoR family CWD84_15255 ENOG4105CS2 ec 3.2.1.21 CWD84_15260 ENOG4105VCP PTS System CWD84_15265 ENOG4105CK1 PTS System CWD84_15270 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CWD84_15275 ENOG4105CMR udp-glucose 4-epimerase CWD84_15280 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase CWD84_15295 ENOG4105C0R drug resistance transporter emrb qaca subfamily CWD84_15755 ENOG410635T phage-like element pbsx protein CWD84_15760 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) CWD84_15770 ENOG4105C28 cystathionine CWD84_15775 ENOG4105C28 cystathionine CWD84_15785 ENOG4108ZMI UPF0477 protein CWD84_15800 ENOG4105CJ1 ABC, transporter CWD84_15820 ENOG4105ENA helicase CWD84_15870 ENOG4107A88 CWD84_15875 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CWD84_15880 ENOG4105DWF phosphomethylpyrimidine kinase CWD84_15885 ENOG4105D06 uba thif-type nad fad binding protein CWD84_15905 ENOG4108VEU Thiamine monophosphate synthase CWD84_15910 ENOG4105ETU transcriptional activator (TenA CWD84_15920 ENOG4107S1Q Phosphatase CWD84_15925 ENOG4105EMS pseudouridine synthase CWD84_15930 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CWD84_15945 ENOG4105MIX Adenylate cyclase CWD84_15950 ENOG4105E4C Lytic transglycosylase catalytic CWD84_15955 ENOG4108Z18 K06886 hemoglobin CWD84_15960 ENOG4105T58 Dithiol-disulfide isomerase CWD84_15965 ENOG4105DPN Oligoendopeptidase f CWD84_15975 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis CWD84_15980 ENOG4108ZCF integral membrane protein CWD84_15985 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CWD84_16000 ENOG4108JQ7 (ABC) transporter CWD84_16010 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CWD84_16015 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CWD84_16020 ENOG4108J59 Extracellular solute-binding protein, family 5 CWD84_16030 ENOG4105C31 Tryptophanyl-tRNA synthetase CWD84_16040 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CWD84_16055 ENOG4108JQ7 (ABC) transporter CWD84_16060 ENOG4105C3U ABC transporter CWD84_16070 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CWD84_16075 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CWD84_16090 ENOG4107RMD Basic membrane lipoprotein CWD84_16120 ENOG4105DBV ornithine carbamoyltransferase CWD84_16130 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CWD84_16135 ENOG4105C8Y Acetylornithine aminotransferase CWD84_16140 ENOG4105CAS nag kinase CWD84_16150 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CWD84_16160 ENOG4105IQ5 FAD linked oxidase domain protein CWD84_16170 ENOG4105VG1 fes assembly suf system protein CWD84_16175 ENOG4108MXZ Esterase CWD84_16180 ENOG4108KP7 hydrolase CWD84_16185 ENOG41073B9 CWD84_16195 ENOG4107AYK membrAne CWD84_16200 ENOG4105EPR degv family CWD84_16210 ENOG4105QNR S1 RNA binding domain protein CWD84_16215 ENOG4108VPT UPF0234 protein CWD84_16230 ENOG4105MYW Pentapeptide repeat protein CWD84_16235 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CWD84_16240 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CWD84_16245 ENOG4105SF0 DinB family CWD84_16250 ENOG4106HBX Transcriptional Regulator AraC Family CWD84_16255 ENOG4105UQX Mate efflux family protein CWD84_16265 ENOG4105CAQ asparagine synthetase CWD84_16285 ENOG4105ERH Fumarylacetoacetate hydrolase CWD84_16330 ENOG4105EYH Exonuclease CWD84_16340 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CWD84_16345 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination CWD84_16350 ENOG4108QY0 Membrane CWD84_16360 ENOG4108IG5 Transcriptional regulator CWD84_16370 ENOG4108KK1 membrane protein AbrB duplication CWD84_16375 ENOG4108INS Transcriptional regulator CWD84_16380 ENOG4107SCK Monooxygenase CWD84_16395 ENOG41060YP CWD84_16400 ENOG4106CAD Protein of unknown function (DUF3311) CWD84_16405 ENOG4105E1V na solute symporter CWD84_16415 ENOG4105X3H Excalibur domain protein CWD84_16425 ENOG4108ZMX Domain of unknown function (DU1801) CWD84_16430 ENOG4105XVF Competence transcription factor CWD84_16450 ENOG4106YBV Methyl-accepting chemotaxis CWD84_16455 ENOG4107ZYJ bioY protein CWD84_16460 ENOG4107F3J Amp-dependent synthetase and ligase CWD84_16470 ENOG4107TB6 phosphoglycerate mutase CWD84_16475 ENOG4108HUF Transporter CWD84_16490 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CWD84_16500 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_16510 ENOG4105DF9 Lipoate-protein, ligase CWD84_16515 ENOG4108RQ5 Beta-lactamase domain-containing protein CWD84_16520 ENOG4106AXD CWD84_16530 ENOG4105DER m42 family CWD84_16545 ENOG4105ECB domain protein CWD84_16555 ENOG4105C1Q protoporphyrinogen oxidase CWD84_16560 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CWD84_16565 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CWD84_16570 ENOG4105BZ4 penicillin-binding protein CWD84_16575 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CWD84_16605 ENOG4105K59 histidine triad (HIT) protein CWD84_16610 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CWD84_16615 ENOG4105NBU tryptophan transport protein CWD84_16665 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CWD84_16675 ENOG4105EQI Metal Dependent Phosphohydrolase CWD84_16680 ENOG4106D4I domain protein CWD84_16685 ENOG4107VRP DNA repair exonuclease CWD84_16690 ENOG4105RHA ABC transporter, permease CWD84_16695 ENOG4108IUX (ABC) transporter CWD84_16705 ENOG4105CGU Enoyl-CoA hydratase CWD84_16715 ENOG4105NCW Trka-c domain protein CWD84_16720 ENOG4107S91 Sodium hydrogen exchanger CWD84_16730 ENOG4105D4P Coproporphyrinogen iii oxidase CWD84_16740 ENOG4105F1N DNA alkylation repair CWD84_16745 ENOG4105WZB UPF0342 protein CWD84_16750 ENOG4106MP8 UPF0754 membrane protein CWD84_16760 ENOG410839P CWD84_16785 ENOG4105BZ1 (ABC) transporter CWD84_16790 ENOG4105BZ1 (ABC) transporter CWD84_16800 ENOG4105IIP Membrane CWD84_16805 ENOG4105W1N transcriptional regulator CWD84_16810 ENOG4105F0I Aminotransferase CWD84_16815 ENOG4107VMI polysaccharide deacetylase CWD84_16820 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CWD84_16825 ENOG4105D64 Mechanosensitive ion channel CWD84_16835 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CWD84_16840 ENOG4105WMR Protein CrcB homolog CWD84_16850 ENOG4105C37 (CBS) domain CWD84_16855 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase CWD84_16860 ENOG4105CHM Aminotransferase CWD84_16870 ENOG4105C37 (CBS) domain CWD84_16875 ENOG4105F6E Acyl-transferase CWD84_16880 ENOG4108AEY RNA polymerase sigma factor CWD84_16885 ENOG4105J37 CWD84_16900 ENOG4105C8J )-transporter CWD84_16905 ENOG4105CUB amino acid CWD84_16915 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CWD84_16920 ENOG4105BZN citrate synthase CWD84_16935 ENOG4105G6Z alkaline phosphatase CWD84_16940 ENOG4105ED1 spovr family CWD84_16980 ENOG4105BZU Histidine kinase CWD84_16990 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CWD84_16995 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CWD84_17005 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CWD84_17010 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CWD84_17015 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CWD84_17020 ENOG4107YBY Hydrolase CWD84_17025 ENOG41080XP Cbs domain CWD84_17035 ENOG4108YBP pseudouridine synthase CWD84_17075 ENOG4105BZU Histidine kinase CWD84_17090 ENOG4105VEQ Cold shock protein CWD84_17095 ENOG4108TU7 Inherit from COG: (ABC) transporter CWD84_17100 ENOG4105CJ1 ABC, transporter CWD84_17105 ENOG4105CZV ABC transporter CWD84_17110 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CWD84_17125 ENOG4105CS1 NAD(P)H quinone oxidoreductase CWD84_17130 ENOG4105C0R drug resistance transporter emrb qaca subfamily CWD84_17135 ENOG4105CW7 secretion protein, HlyD family CWD84_17140 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CWD84_17150 ENOG4105CYN Serine protein kinase CWD84_17175 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CWD84_17185 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CWD84_17200 ENOG4105VZ8 Transcriptional regulator CWD84_17205 ENOG4107D63 CWD84_17210 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CWD84_17225 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CWD84_17230 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CWD84_17235 ENOG4105E2Y ABC, transporter CWD84_17250 ENOG4108JQ7 (ABC) transporter CWD84_17255 ENOG4105C3U ABC transporter CWD84_17260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CWD84_17280 ENOG4105DNP FAD linked oxidase domain protein CWD84_17285 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CWD84_17290 ENOG4105EC3 peptidase S51, dipeptidase E CWD84_17435 ENOG4105TUA UPF0295 protein CWD84_17440 ENOG4105G5W regulator Fur family CWD84_17445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CWD84_17450 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CWD84_17455 ENOG4107NBY Membrane CWD84_17460 ENOG4105BZ1 (ABC) transporter CWD84_17480 ENOG4105CAN Short-chain dehydrogenase reductase Sdr CWD84_17485 ENOG4106BXE CWD84_17490 ENOG4105CEN a g-specific adenine glycosylase CWD84_17495 ENOG410780I phosphoprotein phosphatase activity CWD84_17555 ENOG4108FKH Transglycosylase SLT domain CWD84_17595 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CWD84_17660 ENOG4105CDU Replicative dna helicase CWD84_17685 ENOG4108ZUE Phage regulatory protein rha CWD84_17720 ENOG4105VTR Integrase CWD84_17730 ENOG41067AE Membrane-bound metal-dependent hydrolase CWD84_17735 ENOG4105EJV Membrane CWD84_17740 ENOG4105CKK Glycosyl transferase, family 2 CWD84_17745 ENOG4105D74 hydrolase CWD84_17750 ENOG4106AKJ CWD84_17770 ENOG4105F27 Major Facilitator CWD84_17780 ENOG410902V Modulates RecA activity (By similarity) CWD84_17785 ENOG4105ECP epimerase CWD84_17800 ENOG4107Y03 Nitroreductase CWD84_17805 ENOG4105JAB phenazine biosynthesis protein, phzf family CWD84_17815 ENOG410834F Transcriptional regulator CWD84_17820 ENOG4105C0R drug resistance transporter emrb qaca subfamily CWD84_17825 ENOG4108YYS metal-dependent hydrolase (By similarity) CWD84_17840 ENOG4105H93 Acyltransferase family CWD84_17845 ENOG4105DYS nad(p)h dehydrogenase (quinone) CWD84_17850 ENOG4105U3E Transcriptional regulator CWD84_17855 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CWD84_17865 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CWD84_17875 ENOG4105BZ1 (ABC) transporter CWD84_17880 ENOG4105BZ1 (ABC) transporter CWD84_17890 ENOG4105CI1 PTS System CWD84_17895 ENOG4108Q3X Transcriptional regulator CWD84_17900 ENOG4105F8D glycoside hydrolase family 4 CWD84_17910 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CWD84_17920 ENOG4107QKR Dehydrogenase CWD84_17930 ENOG4107RUY (E1 component), alpha subunit CWD84_17960 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CWD84_17970 ENOG4105D7N magnesium and cobalt transport protein CorA CWD84_17980 ENOG4106KE4 Dehydrogenase CWD84_18000 ENOG4105D8X mechanosensitive ion channel CWD84_18010 ENOG4105UPD Calcium Proton CWD84_18015 ENOG4108ISG Major Facilitator CWD84_18020 ENOG4107U9T Pfam:Ribonuclease_BN CWD84_18030 ENOG4105KJF protein tyrosine phosphatase CWD84_18045 ENOG4105FF2 Type I DHQase CWD84_18050 ENOG4105E2X shikimate dehydrogenase CWD84_18055 ENOG4105ETE Transcriptional regulator (LacI family CWD84_18060 ENOG4107RKG DJ-1/PfpI family CWD84_18065 ENOG4105CGH 5'-nucleotidase CWD84_18080 ENOG4108RCM Nitroreductase CWD84_18125 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CWD84_18145 ENOG4108RPX mosc domain containing protein CWD84_18150 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) CWD84_18175 ENOG4108MRH transcriptional regulatory protein CWD84_18195 ENOG4107QPK )-transporter CWD84_18200 ENOG4108J20 pectate lyase CWD84_18215 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CWD84_18225 ENOG4105FDU atp-dependent rna helicase CWD84_18230 ENOG4105C5H ABC transporter CWD84_18235 ENOG4105DXB Major Facilitator superfamily CWD84_18240 ENOG4107SWG transcriptional regulator MERR family CWD84_18260 ENOG4105C5H ABC transporter CWD84_18265 ENOG4107TVC Glycosyl transferase, family 2 CWD84_18270 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CWD84_18275 ENOG4105FKZ Methyl-accepting chemotaxis CWD84_18280 ENOG4105C26 Dehydrogenase CWD84_18285 ENOG4105CUB amino acid CWD84_18290 ENOG4105EU0 Major facilitator Superfamily CWD84_18295 ENOG41090R9 glycosyltransferase CWD84_18300 ENOG4107R51 Glycosyl transferase, family 2 CWD84_18305 ENOG41090R9 glycosyltransferase CWD84_18315 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CWD84_18320 ENOG4105E0M Sulfatase CWD84_18325 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CWD84_18330 ENOG4108R1P CWD84_18335 ENOG41061H0 Monooxygenase CWD84_18340 ENOG41082F9 transcriptional regulator CWD84_18345 ENOG4106I4J membrane CWD84_18365 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CWD84_18370 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CWD84_18375 ENOG4105H67 Protein of unknown function (DUF421) CWD84_18385 ENOG4105M18 -acetyltransferase CWD84_18390 ENOG4105WEF catalase CWD84_18410 ENOG4105CDY transcriptional regulatory protein CWD84_18440 ENOG4105D9P serine threonine protein kinase CWD84_18455 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CWD84_18460 ENOG4105CBD Diacylglycerol kinase CWD84_18470 ENOG4108IG5 Transcriptional regulator CWD84_18475 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CWD84_18480 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CWD84_18485 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CWD84_18490 ENOG4105CK7 Sodium proline symporter CWD84_18495 ENOG4105KT7 mgtC SapB transporter CWD84_18500 ENOG4105CRN Aminoglycoside phosphotransferase CWD84_18510 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CWD84_18515 ENOG4105C4R Atp-dependent dna helicase CWD84_18530 ENOG4105CBC glutamate synthase CWD84_18535 ENOG4105KGF protein, YerC YecD CWD84_18540 ENOG4108R5T secreted protein CWD84_18555 ENOG4105C12 Phosphoribosylglycinamide synthetase CWD84_18560 ENOG4105DC1 bifunctional purine biosynthesis protein purh CWD84_18565 ENOG4108V3E phosphoribosylglycinamide formyltransferase CWD84_18570 ENOG4105CXB phosphoribosylaminoimidazole synthetase CWD84_18580 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CWD84_18585 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CWD84_18590 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CWD84_18595 ENOG4105C8V SAICAR synthetase CWD84_18600 ENOG4105C83 adenylosuccinate lyase CWD84_18605 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CWD84_18610 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CWD84_18635 ENOG4105C7N Xanthine uracil vitamin C permease CWD84_18650 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CWD84_18665 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CWD84_18685 ENOG4106IBS oxygenase CWD84_18690 ENOG4105CPF Cell wall formation (By similarity) CWD84_18705 ENOG4105C5S asparaginyl-tRNA synthetase CWD84_18715 ENOG4105C85 amino acid CWD84_18720 ENOG4107STQ Multicopper oxidase CWD84_18745 ENOG4105JVQ RNA Polymerase CWD84_18750 ENOG4108P49 AntiSigma factor CWD84_18755 ENOG4105EXC Acyl-transferase CWD84_18765 ENOG4108WV1 Pfam:DUF477 CWD84_18770 ENOG4105DQX Zinc finger domain CWD84_18775 ENOG41087YS Phage shock protein A CWD84_18790 ENOG4105CT4 transporter CWD84_18795 ENOG4105CPQ Dehydrogenase CWD84_18800 ENOG4105PGZ NB-ARC domain CWD84_18815 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CWD84_18820 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CWD84_18825 ENOG4108TYN CAAX amino terminal protease family protein CWD84_18835 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CWD84_18840 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CWD84_18845 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CWD84_18850 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CWD84_18855 ENOG4105C5H ABC transporter CWD84_18860 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CWD84_18865 ENOG410801F ribosomal-protein-alanine acetyltransferase CWD84_18870 ENOG41072GX Peptidase M22 Glycoprotease CWD84_18875 ENOG4105K8N protein family UPF0079, ATPase CWD84_18880 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CWD84_18920 ENOG4107QNK )-transporter CWD84_18940 ENOG4107QTZ amino acid CWD84_18960 ENOG4105DJ2 Major Facilitator Superfamily CWD84_18965 ENOG4105JXH GntR family transcriptional regulator CWD84_18975 ENOG4108SUT Major Facilitator Superfamily CWD84_18980 ENOG41090UD (LipO)protein CWD84_18985 ENOG4105FQP Beta-lactamase CWD84_19005 ENOG4105DRR Transcriptional regulator, GntR family CWD84_19010 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CWD84_19015 ENOG4105EBM Alpha Beta Hydrolase Fold protein CWD84_19040 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CWD84_19045 ENOG4105C2C drug resistance transporter, Bcr CflA CWD84_19055 ENOG4108JYZ YitT family CWD84_19075 ENOG4105EYF MMPL domain protein CWD84_19080 ENOG4108VB1 regulatoR CWD84_19085 ENOG4105ENE Histidine kinase CWD84_19090 ENOG4108UW5 maltose o-acetyltransferase CWD84_19100 ENOG4106UW1 Major Facilitator superfamily CWD84_19110 ENOG4105PGS Spore coat protein CWD84_19115 ENOG4105E2A Dehydrogenase CWD84_19160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CWD84_19170 ENOG4105VUF Transcriptional regulator CWD84_19175 ENOG4105DQ4 alcohol dehydrogenase CWD84_19195 ENOG4108U7W acetyltransferase CWD84_19200 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CWD84_19210 ENOG4105PGM cation diffusion facilitator family transporter CWD84_19220 ENOG4105DNP FAD linked oxidase domain protein CWD84_19235 ENOG41082W1 Cupin 2, conserved barrel domain protein CWD84_19245 ENOG4105IRW patatin-like phospholipase family protein CWD84_19250 ENOG4105DCM major facilitator superfamily CWD84_19255 ENOG410645S MarR family Transcriptional regulator CWD84_19275 ENOG4105CIH Imidazole acetol-phosphate transaminase CWD84_19280 ENOG4105CSH Transporter CWD84_19300 ENOG4105C0R drug resistance transporter emrb qaca subfamily CWD84_19305 ENOG4105DJ2 Major Facilitator Superfamily CWD84_19310 ENOG4108J2R molybdopterin oxidoreductase CWD84_19315 ENOG4105GZI Transcriptional regulator CWD84_19320 ENOG4108VJ1 Transcriptional regulator (CarD family CWD84_19325 ENOG4105VEQ Cold shock protein CWD84_19330 ENOG4108NEM leader-binding protein dmsD CWD84_19340 ENOG4108RYK Nad-dependent epimerase dehydratase CWD84_19345 ENOG4108Z40 Transcriptional regulator CWD84_19350 ENOG4108ZMQ domain protein CWD84_19360 ENOG4105K56 Transcriptional regulator CWD84_19395 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CWD84_19415 ENOG410847I Transcriptional regulator, BadM Rrf2 family CWD84_19425 ENOG4105I1F Resistance protein CWD84_19470 ENOG410906U SprT-like CWD84_19485 ENOG41064BQ Phosphatase CWD84_19495 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CWD84_19500 ENOG4105WN5 stage II sporulation protein CWD84_19505 ENOG4107SGM protein serine threonine phosphatase CWD84_19510 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CWD84_19515 ENOG4105FUA antagonist CWD84_19520 ENOG4107MMM Anti-sigma-factor antagonist CWD84_19525 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CWD84_19535 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CWD84_19540 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CWD84_19545 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CWD84_19555 ENOG4105CKV Membrane CWD84_19560 ENOG410905X membrane-flanked domain protein CWD84_19565 ENOG4105C1J atp-dependent rna helicase CWD84_19570 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CWD84_19575 ENOG4105CPF Cell wall formation (By similarity) CWD84_19580 ENOG4105SZ6 Thioredoxin CWD84_19600 ENOG4105FDT acyl-CoA dehydrogenase CWD84_19615 ENOG4105CJ1 ABC, transporter CWD84_19620 ENOG4106F5Q Membrane CWD84_19625 ENOG4107QJT sodium dicarboxylate symporter CWD84_19630 ENOG4108MRH transcriptional regulatory protein CWD84_19635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CWD84_19640 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CWD84_19655 ENOG41082W1 Cupin 2, conserved barrel domain protein CWD84_19660 ENOG4105QVS general stress protein CWD84_19665 ENOG4105EU9 CWD84_19670 ENOG4105KPY Small multidrug resistance protein CWD84_19675 ENOG4105RXJ CWD84_19680 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CWD84_19695 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CWD84_19750 ENOG4105C0X amino acid CWD84_19760 ENOG4107R8N Glycosyl transferase, family 2 CWD84_19765 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CWD84_19780 ENOG4105C9U ATP-dependent DNA helicase RecQ CWD84_19790 ENOG4105VCH membrane CWD84_19800 ENOG410606W general stress protein CWD84_19805 ENOG4108Z9I -acetyltransferase CWD84_19815 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CWD84_19825 ENOG4105ETD TRANSCRIPTIONal CWD84_19830 ENOG4107QM2 Aldo Keto reductase CWD84_19835 ENOG4107RVG penicillin-binding protein CWD84_19840 ENOG41061CK Antibiotic biosynthesis monooxygenase CWD84_19850 ENOG4105XJB lipolytic protein G-D-S-L family CWD84_19855 ENOG4107258 Transcriptional regulator CWD84_19865 ENOG4105P4J Allophanate hydrolase, subunit 1 CWD84_19870 ENOG4105CFM UPF0317 protein CWD84_19875 ENOG4105C5A transporter CWD84_19880 ENOG4105E7W lamb ycsf family protein CWD84_19900 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase CWD84_19920 ENOG4108ZYE Transcriptional regulator CWD84_19925 ENOG4108T5E Copper resistance protein CWD84_19930 ENOG4105KTB nuclear export factor GLE1 CWD84_19935 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CWD84_19945 ENOG4105C26 Dehydrogenase CWD84_19950 ENOG4108JPW Aminotransferase CWD84_19960 ENOG4105YVS arsR family transcriptional regulator CWD84_19965 ENOG41067V3 Antibiotic biosynthesis monooxygenase CWD84_19970 ENOG4108DBC nitroreductase CWD84_19975 ENOG4105R8C Transcriptional regulator CWD84_19990 ENOG4108IPW abc transporter atp-binding protein CWD84_19995 ENOG4105CM4 permease protein CWD84_20000 ENOG4105DHS permease protein CWD84_20005 ENOG4105CFH Aspartokinase CWD84_20025 ENOG4105BZU Histidine kinase CWD84_20030 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CWD84_20035 ENOG4107WD8 ABC transporter, permease CWD84_20045 ENOG4108PGP mmge prpd family protein CWD84_20050 ENOG4105CH2 amidohydrolase CWD84_20060 ENOG4108HW4 amino acid AbC transporter CWD84_20065 ENOG4105EAB amino acid AbC transporter CWD84_20070 ENOG4108XSB acetyltransferase, (GNAT) family CWD84_20075 ENOG4105CPU Monooxygenase CWD84_20090 ENOG4105E1K spore germination protein CWD84_20105 ENOG4105DUX Transporter CWD84_20110 ENOG41069ZX CWD84_20115 ENOG41069ZX CWD84_20120 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CWD84_20125 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CWD84_20130 ENOG4106P55 Transcriptional regulator CWD84_20140 ENOG4105DRP amino acid AbC transporter CWD84_20145 ENOG4105CDA abc transporter atp-binding protein CWD84_20160 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CWD84_20180 ENOG4105CEY Amp-dependent synthetase and ligase CWD84_20185 ENOG4105KVH Transcriptional regulator CWD84_20190 ENOG4108VA3 3-hexulose-6-phosphate synthase CWD84_20195 ENOG41080HJ 6-phospho 3-hexuloisomerase CWD84_20220 ENOG4105HHM rdd domain containing protein CWD84_20225 ENOG4105E2A Dehydrogenase CWD84_20230 ENOG4105CKI cobalamin synthesis protein CWD84_20235 ENOG4108IFG nitrite reductase, (NAD(P)H) CWD84_20240 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CWD84_20245 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CWD84_20250 ENOG4105CAY ferredoxin--nadp reductase CWD84_20255 ENOG4107YHD transcriptional regulator CWD84_20260 ENOG4105CK7 Sodium proline symporter CWD84_20265 ENOG4105C26 Dehydrogenase CWD84_20275 ENOG410756H nucleotidyltransferase CWD84_20280 ENOG4105I82 acetyl xylan esterase CWD84_20285 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CWD84_20290 ENOG4105DJB Major Facilitator Superfamily CWD84_20305 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CWD84_20310 ENOG4105EIG urea carboxylase-associated protein 1 CWD84_20340 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CWD84_20375 ENOG4107SQ8 Glycine betaine CWD84_20380 ENOG4108IJ7 Glycine betaine CWD84_20385 ENOG41079KZ Major Facilitator Superfamily CWD84_20395 ENOG4108TTB tellurium resistance protein CWD84_20400 ENOG4107TS3 membrane protein, TerC CWD84_20405 ENOG4106FN3 tellurium resistance protein CWD84_20410 ENOG4106FN3 tellurium resistance protein CWD84_20415 ENOG4108N0M stress protein CWD84_20430 ENOG4105DIK (ABC) transporter CWD84_20435 ENOG4105DSE periplasmic solute binding protein CWD84_20455 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CWD84_20485 ENOG4107SET aldo keto reductase CWD84_20490 ENOG41060AI SEC-C motif CWD84_20500 ENOG4107RB3 L-asparaginase CWD84_20505 ENOG4105J7D transcriptional regulator CWD84_20510 ENOG4105C0R drug resistance transporter emrb qaca subfamily CWD84_20515 ENOG4107EPV Aminotransferase class V CWD84_20520 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CWD84_20525 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CWD84_20530 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CWD84_20535 ENOG4105DGI Alkaline phosphatase CWD84_20560 ENOG4105XXY Thioredoxin CWD84_20565 ENOG4108VGI doxx family CWD84_20570 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CWD84_20575 ENOG4108TVJ Nitroreductase CWD84_20580 ENOG41076HS cation diffusion facilitator family transporter CWD84_20595 ENOG4105CSV Glutaminase CWD84_20605 ENOG4108J5H Homocysteine s-methyltransferase CWD84_20610 ENOG4108IQI permease CWD84_20615 ENOG4105CM2 brancheD-chain amino acid aminotransferase CWD84_20625 ENOG4105C72 UPF0176 protein CWD84_20640 ENOG4107ZTW SNARE associated Golgi CWD84_20645 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CWD84_20650 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CWD84_20655 ENOG4107SCQ Iron-containing alcohol dehydrogenase CWD84_20665 ENOG4106BHF CWD84_20700 ENOG4105CXY transporter CWD84_20705 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CWD84_20720 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) CWD84_20725 ENOG4107QTZ amino acid CWD84_20740 ENOG4106DDH Sporulation-specific SASP protein CWD84_20755 ENOG41090VJ ABC-2 type transporter CWD84_20765 ENOG4105CJ1 ABC, transporter CWD84_20770 ENOG4105WH1 Two component transcriptional regulator luxr family CWD84_20775 ENOG4105BZU Histidine kinase CWD84_20790 ENOG41061AU MarR family Transcriptional regulator CWD84_20800 ENOG41067MG lrgb family CWD84_20810 ENOG4106K80 CWD84_20825 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CWD84_20835 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CWD84_20840 ENOG4107U5W ybbr family CWD84_20845 ENOG4105C8B TIGR00159 family CWD84_20855 ENOG4105EMN RNA polymerase sigma factor CWD84_20885 ENOG4105EWC Purine nucleoside phosphorylase CWD84_20895 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CWD84_20910 ENOG4105D17 glycoside hydrolase, family 3 domain protein CWD84_20915 ENOG4105EHZ conserved protein UCP016719 CWD84_20920 ENOG410874W AraC family transcriptional regulator CWD84_20940 ENOG4108SA1 esterase CWD84_20955 ENOG4105CPQ Dehydrogenase CWD84_20965 ENOG4108JPW Aminotransferase CWD84_21030 ENOG4108NMV polysaccharide deacetylase CWD84_21045 ENOG4105D1F ATP-binding protein CWD84_21065 ENOG4108I0C methyltransferase CWD84_21070 ENOG4108UJD 30S ribosomal protein S9 CWD84_21075 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CWD84_21080 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CWD84_21085 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CWD84_21090 ENOG4108JJB ABC transporter CWD84_21095 ENOG4108JJB ABC transporter CWD84_21100 ENOG4108ZT0 50S ribosomal protein l17 CWD84_21105 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CWD84_21110 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CWD84_21115 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CWD84_21125 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CWD84_21135 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CWD84_21140 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CWD84_21145 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CWD84_21150 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CWD84_21155 ENOG4105VPB 50S ribosomal protein L30 CWD84_21160 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CWD84_21165 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CWD84_21170 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CWD84_21175 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CWD84_21185 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CWD84_21200 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CWD84_21205 ENOG41082SA 50s ribosomal protein l29 CWD84_21210 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CWD84_21215 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CWD84_21220 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CWD84_21225 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CWD84_21230 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CWD84_21235 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CWD84_21240 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CWD84_21245 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CWD84_21250 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CWD84_21255 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CWD84_21260 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CWD84_21265 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CWD84_21270 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CWD84_21275 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CWD84_21280 ENOG4105XPM ribosomal protein CWD84_21285 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CWD84_21290 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CWD84_21295 ENOG4107Y49 methyltransferase CWD84_21300 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CWD84_21305 ENOG4108VZM 50s ribosomal protein L10 CWD84_21315 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CWD84_21320 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CWD84_21340 ENOG4105M0M Tetracycline resistance protein CWD84_21345 ENOG4105C2N RNA methyltransferase TrmH family group 3 CWD84_21350 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CWD84_21360 ENOG4105D7W serine acetyltransferase CWD84_21365 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CWD84_21370 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CWD84_21375 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CWD84_21380 ENOG4105CTP PilT protein domain protein CWD84_21385 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CWD84_21390 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CWD84_21400 ENOG41066A3 ATP guanido phosphotransferase CWD84_21405 ENOG4108Z0C Uvrb UvrC protein CWD84_21495 ENOG4105CRK lysyL-tRNA synthetase CWD84_21500 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CWD84_21510 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CWD84_21515 ENOG4105KRF dihydroneopterin aldolase CWD84_21520 ENOG4105EEI dihydropteroate synthase CWD84_21525 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CWD84_21530 ENOG4105DDQ anthranilate synthase CWD84_21535 ENOG4105CRQ synthase (Component I) CWD84_21540 ENOG4105C6T cysteine synthase CWD84_21545 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase CWD84_21550 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CWD84_21555 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) CWD84_21560 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CWD84_21565 ENOG4108UGV hypoxanthine phosphoribosyltransferase CWD84_21570 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CWD84_21600 ENOG41060GV RNA binding s1 domain protein CWD84_21615 ENOG4105VYY sporulation protein yabp CWD84_21620 ENOG41082I2 s4 domain protein CWD84_21625 ENOG4108IY2 MazG family CWD84_21635 ENOG4108M14 stage v sporulation protein t CWD84_21640 ENOG4108JA2 transcriptioN-repair coupling factor CWD84_21655 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CWD84_21660 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CWD84_21665 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CWD84_21670 ENOG4105K4W Could be involved in septation (By similarity) CWD84_21675 ENOG4105KME endoribonuclease L-psp CWD84_21680 ENOG4105DFT pur operon repressor CWD84_21685 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CWD84_21690 ENOG4105XEW small acid-soluble spore protein CWD84_21695 ENOG4105W42 Veg protein CWD84_21700 ENOG4105XFA sporulation peptidase YabG CWD84_21705 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CWD84_21715 ENOG41069ER domain protein CWD84_21720 ENOG4105F8V Hydrolase, tatD family CWD84_21725 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CWD84_21730 ENOG4105KRN Transcriptional regulator, abrb family CWD84_21735 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CWD84_21740 ENOG4105VC4 domain protein CWD84_21745 ENOG41060K3 Methyltransferase CWD84_21755 ENOG4105MA4 psp1 domain protein CWD84_21760 ENOG4105FA2 dna polymerase iii CWD84_21765 ENOG4105XVJ Protein of unknown function (DUF327) CWD84_21770 ENOG4105X0R protein from nitrogen regulatory protein P-II CWD84_21775 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CWD84_21780 ENOG4105CXN decarboxylase CWD84_21785 ENOG4105CDW Resistance protein CWD84_21825 ENOG41067KS pro-sigma K processing CWD84_21835 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CWD84_21840 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CWD84_21845 ENOG4105C6E dna polymerase iii CWD84_21855 ENOG4108Z6B deaminase CWD84_21860 ENOG4105GTG Isochorismatase CWD84_21865 ENOG4105VRS hydrolase family 18 CWD84_21875 ENOG4105ZMH deoxynucleoside kinase CWD84_21885 ENOG4105BZW Glycerate kinase CWD84_21890 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CWD84_21895 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CWD84_21900 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CWD84_21910 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CWD84_21945 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWD84_21950 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CWD84_21960 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) CWD84_21965 ENOG410848D S4 domain protein YaaA CWD84_21970 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)