locus-tag class description BS1321_00055 ENOG4108VXD carboxy-peptidase BS1321_00060 ENOG4108KGH TRANSCRIPTIONal BS1321_00080 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_00095 ENOG4105C5E polysaccharide biosynthesis protein BS1321_00115 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BS1321_00155 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BS1321_00160 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BS1321_00165 ENOG4105DUM transcriptional regulator, lysR family BS1321_00180 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BS1321_00185 ENOG4105RHY Pfam:UPF0157 BS1321_00215 ENOG4107RB3 L-asparaginase BS1321_00220 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BS1321_00235 ENOG4105DEN Luciferase family BS1321_00245 ENOG4105F27 Major Facilitator BS1321_00255 ENOG4105WAB arsR family transcriptional regulator BS1321_00270 ENOG4108UW5 maltose o-acetyltransferase BS1321_00280 ENOG4107HP6 Transcriptional regulator BS1321_00285 ENOG4105F27 Major Facilitator BS1321_00295 ENOG41061CK Antibiotic biosynthesis monooxygenase BS1321_00300 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BS1321_00315 ENOG4105EMU Dehydrogenase BS1321_00320 ENOG4108RWP Major Facilitator Superfamily protein BS1321_00325 ENOG4105CF7 AraC family transcriptional regulator BS1321_00340 ENOG4105CHR reductase BS1321_00345 ENOG4105VI0 Pts system, glucitol sorbitol-specific BS1321_00350 ENOG4105DZY Pts system, glucitol sorbitol-specific BS1321_00355 ENOG410787A Pts system, glucitol sorbitol-specific BS1321_00365 ENOG4105DKT Transcriptional regulator BS1321_00370 ENOG4105QIV RNA polymerase BS1321_00380 ENOG4105K6H D-cysteine desulfhydrase BS1321_00390 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase BS1321_00395 ENOG4105XRQ Xanthine dehydrogenase accessory factor BS1321_00430 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase BS1321_00440 ENOG4105FUY alpha subunit BS1321_00455 ENOG4105C7K acetolactate synthase BS1321_00460 ENOG4105CHR reductase BS1321_00475 ENOG4107HP6 Transcriptional regulator BS1321_00495 ENOG4105C6Z Gluconate BS1321_00500 ENOG4105FDP GntR family transcriptional regulator BS1321_00520 ENOG41069H0 dihydroorotase EC 3.5.2.3 BS1321_00535 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_00550 ENOG4105D9R oxidoreductase BS1321_00565 ENOG4105EHZ conserved protein UCP016719 BS1321_00570 ENOG4105D17 glycoside hydrolase, family 3 domain protein BS1321_00590 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BS1321_00600 ENOG4108IV0 ABC, transporter BS1321_00605 ENOG4105C0Z ABC transporter BS1321_00610 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BS1321_00615 ENOG4105C32 Amino acid ABC transporter (Permease) BS1321_00635 ENOG410900P UPF0336 protein BS1321_00640 ENOG4105CHR reductase BS1321_00645 ENOG4105C1G acyl-Coa dehydrogenase BS1321_00650 ENOG4105C1G acyl-Coa dehydrogenase BS1321_00655 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_00665 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS1321_00670 ENOG4105K4P CoA-binding domain protein BS1321_00675 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BS1321_00680 ENOG4106YBV Methyl-accepting chemotaxis BS1321_00695 ENOG4105E09 nadh pyrophosphatase BS1321_00700 ENOG4105W8X HesB YadR YfhF-family protein BS1321_00705 ENOG4105MI2 BS1321_00715 ENOG41067CD Small, acid-soluble spore protein Tlp BS1321_00730 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS1321_00735 ENOG4108I0Z Aconitate hydratase BS1321_00740 ENOG410746C Acid-soluble spore protein O BS1321_00750 ENOG41076DU acid-soluble spore protein P BS1321_00755 ENOG4105D06 uba thif-type nad fad binding protein BS1321_00760 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BS1321_00765 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BS1321_00770 ENOG41080HI glycine oxidase BS1321_00775 ENOG4108VEU Thiamine monophosphate synthase BS1321_00780 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BS1321_00785 ENOG4108JJB ABC transporter BS1321_00790 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BS1321_00795 ENOG4105ETU transcriptional activator (TenA BS1321_00805 ENOG4105D2S major facilitator superfamily BS1321_00835 ENOG4105KME endoribonuclease L-psp BS1321_00855 ENOG4105EFA 4-hydroxyphenylacetate BS1321_00865 ENOG4105G0J serine threonine protein kinase BS1321_00875 ENOG4105K70 DNA-binding protein BS1321_00880 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BS1321_00885 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BS1321_00895 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS1321_00900 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BS1321_00905 ENOG4108P62 biosynthesis protein (CbiG) BS1321_00910 ENOG4105CIA precorrin-4 C(11)-methyltransferase BS1321_00915 ENOG4105DVK Precorrin-2 c20-methyltransferase BS1321_00920 ENOG4105CX4 Precorrin-6y C5,15-methyltransferase BS1321_00925 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) BS1321_00930 ENOG41081F0 Precorrin-8x methylmutase BS1321_00935 ENOG4108JTQ reductase BS1321_00940 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BS1321_00945 ENOG4105E4R Precorrin-3B C17-methyltransferase BS1321_00955 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) BS1321_00965 ENOG4108V4M Cobalt abc transporter BS1321_00970 ENOG4108JJB ABC transporter BS1321_00985 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_00995 ENOG4107F9Y LysR family transcriptional regulator BS1321_01000 ENOG4108I5G Major Facilitator superfamily BS1321_01005 ENOG4105EUZ Beta-lactamase domain protein BS1321_01010 ENOG4105DUM transcriptional regulator, lysR family BS1321_01030 ENOG4108RAV Conserved protein BS1321_01035 ENOG41088SP formiminoglutamate hydrolase BS1321_01045 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS1321_01065 ENOG4105HEI LysR family (Transcriptional regulator BS1321_01080 ENOG4105DYB Isoaspartyl dipeptidase BS1321_01100 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase BS1321_01105 ENOG4105DJB Major Facilitator Superfamily BS1321_01115 ENOG4107258 Transcriptional regulator BS1321_01130 ENOG4105WH1 Two component transcriptional regulator luxr family BS1321_01170 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BS1321_01185 ENOG4105P4J Allophanate hydrolase, subunit 1 BS1321_01190 ENOG4105CFM UPF0317 protein BS1321_01195 ENOG4105C5A transporter BS1321_01200 ENOG4105E7W lamb ycsf family protein BS1321_01210 ENOG4105C84 Histidine ammonia-lyase BS1321_01215 ENOG4105C54 Major Facilitator superfamily BS1321_01220 ENOG4105CI2 imidazolone-5-propionate hydrolase BS1321_01225 ENOG4105CGP Urocanate hydratase BS1321_01230 ENOG4105ECQ AraC Family Transcriptional Regulator BS1321_01250 ENOG4105IQ5 FAD linked oxidase domain protein BS1321_01265 ENOG4105SX7 Transporter BS1321_01295 ENOG4105CY2 Citrate transporter BS1321_01300 ENOG4105E39 Enoyl-CoA hydratase BS1321_01310 ENOG4108JUB Transcriptional regulator BS1321_01315 ENOG4105CPP Dehydrogenase, E1 component BS1321_01335 ENOG4105BZ1 (ABC) transporter BS1321_01340 ENOG4108U05 Transcriptional regulator BS1321_01345 ENOG41082BV acetyltransferase BS1321_01385 ENOG4105D4T Citrate transporter BS1321_01390 ENOG4108JUB Transcriptional regulator BS1321_01395 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BS1321_01410 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS1321_01430 ENOG4105C85 amino acid BS1321_01440 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS1321_01445 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_01450 ENOG4105DGI Alkaline phosphatase BS1321_01460 ENOG4108JQ7 (ABC) transporter BS1321_01470 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS1321_01475 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS1321_01480 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BS1321_01485 ENOG4105C5I Dehydrogenase BS1321_01490 ENOG4105DJB Major Facilitator Superfamily BS1321_01505 ENOG4105C59 p-type ATPase BS1321_01510 ENOG410681U heavy metal transport detoxification protein BS1321_01515 ENOG4105VPX protein, conserved in bacteria BS1321_01520 ENOG4105DUM transcriptional regulator, lysR family BS1321_01530 ENOG4105CHU acetyl-coa acetyltransferase BS1321_01540 ENOG4105C1G acyl-Coa dehydrogenase BS1321_01545 ENOG4108W6C Dehydrogenase BS1321_01555 ENOG4108R85 Short chain dehydrogenase BS1321_01560 ENOG4107RSM transcriptional regulator BS1321_01575 ENOG4105DJB Major Facilitator Superfamily BS1321_01585 ENOG4105CHR reductase BS1321_01600 ENOG4105DJB Major Facilitator Superfamily BS1321_01610 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_01625 ENOG4105RHA ABC transporter, permease BS1321_01630 ENOG4108IUX (ABC) transporter BS1321_01635 ENOG4105E98 transcriptional regulator DeoR family BS1321_01640 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BS1321_01645 ENOG4105DET Rhamnulokinase BS1321_01650 ENOG4105EF1 ribulokinase BS1321_01655 ENOG4105D4B ABC, transporter BS1321_01660 ENOG4105F5R ABC transporter BS1321_01665 ENOG4105CNN ABC, transporter BS1321_01670 ENOG4105C2J ABC transporter BS1321_01675 ENOG4108RVA ribokinase BS1321_01680 ENOG4105DJV ribulose-phosphate 3-epimerase BS1321_01685 ENOG4107XVH Transcriptional regulator BS1321_01690 ENOG4105C2F Histidine kinase BS1321_01695 ENOG4105D4B ABC, transporter BS1321_01705 ENOG4105DKG l-rhamnose isomerase BS1321_01720 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BS1321_01735 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_01745 ENOG4108ZDA Sporulation protein YyaC BS1321_01755 ENOG4108KAM Transcriptional regulator BS1321_01760 ENOG4105C7F AcnD-accessory protein PrpF BS1321_01765 ENOG4107EFR Flavocytochrome c BS1321_01770 ENOG4108KAM Transcriptional regulator BS1321_01790 ENOG4105CV8 reductase BS1321_01810 ENOG4108Z7R Chaperone CsaA BS1321_01815 ENOG4108NIW Leucine export protein LeuE BS1321_01860 ENOG4105QIV RNA polymerase BS1321_01920 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BS1321_01925 ENOG41068WN BS1321_01940 ENOG4105D0M Protease HtpX homolog BS1321_01960 ENOG41087NI Sulfite exporter TauE/SafE BS1321_01965 ENOG4105VFE sira family BS1321_01970 ENOG4107TPS domain protein BS1321_01980 ENOG4105VFE sira family BS1321_01990 ENOG4107YZP Rhodanese domain protein BS1321_01995 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase BS1321_02005 ENOG4105XTG Pfam:DUF156 BS1321_02020 ENOG4105CUB amino acid BS1321_02025 ENOG4105C6F GntR Family Transcriptional Regulator BS1321_02030 ENOG4105CG9 aspartate racemase BS1321_02035 ENOG4105DUM transcriptional regulator, lysR family BS1321_02055 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein BS1321_02065 ENOG4105DJB Major Facilitator Superfamily BS1321_02075 ENOG4108QMY dioxygenase BS1321_02080 ENOG4105CHU acetyl-coa acetyltransferase BS1321_02090 ENOG4105DTQ mandelate racemase muconate lactonizing BS1321_02100 ENOG4107QP7 CoA-transferase subunit A BS1321_02115 ENOG4105F2Z 3-oxoadipate enol-lactonase BS1321_02120 ENOG41069ZX BS1321_02125 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BS1321_02130 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BS1321_02140 ENOG4105E98 transcriptional regulator DeoR family BS1321_02145 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS1321_02150 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_02155 ENOG4105DZC cytosine deaminase BS1321_02175 ENOG4105DXI Major Facilitator superfamily BS1321_02185 ENOG4108YXU transcriptional regulator AsnC family BS1321_02205 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BS1321_02210 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BS1321_02215 ENOG4108I5G Major Facilitator superfamily BS1321_02230 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BS1321_02245 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BS1321_02270 ENOG4105CSH Transporter BS1321_02280 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BS1321_02285 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_02290 ENOG4107U9B transcriptional regulator BS1321_02330 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_02345 ENOG4105D6U Sodium Glutamate Symporter BS1321_02350 ENOG41088SP formiminoglutamate hydrolase BS1321_02355 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BS1321_02360 ENOG4105BZU Histidine kinase BS1321_02365 ENOG4105DTQ mandelate racemase muconate lactonizing BS1321_02375 ENOG4108IQI permease BS1321_02410 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_02420 ENOG4105CHU acetyl-coa acetyltransferase BS1321_02425 ENOG4105C1G acyl-Coa dehydrogenase BS1321_02430 ENOG4105CHU acetyl-coa acetyltransferase BS1321_02440 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_02450 ENOG4105ERH Fumarylacetoacetate hydrolase BS1321_02455 ENOG4107GFK fumarate BS1321_02460 ENOG4106DSS Tartrate dehydratase subunit alpha BS1321_02465 ENOG4105D4T Citrate transporter BS1321_02475 ENOG4105CPU Monooxygenase BS1321_02480 ENOG4105CPU Monooxygenase BS1321_02500 ENOG4105DSG hydrolase family 43 BS1321_02520 ENOG4107HP6 Transcriptional regulator BS1321_02525 ENOG4105C01 Dihydroxy-acid dehydratase BS1321_02540 ENOG4107QTZ amino acid BS1321_02555 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS1321_02565 ENOG4105JZI cytochrome P450 BS1321_02575 ENOG4107STQ Multicopper oxidase BS1321_02580 ENOG4105DUX Transporter BS1321_02585 ENOG4105BZU Histidine kinase BS1321_02590 ENOG4105BZU Histidine kinase BS1321_02675 ENOG4105DVE abc transporter atp-binding protein BS1321_02700 ENOG4105C26 Dehydrogenase BS1321_02705 ENOG4105C85 amino acid BS1321_02710 ENOG4108JUB Transcriptional regulator BS1321_02715 ENOG4108JPW Aminotransferase BS1321_02740 ENOG4105PNM synthesis protein BS1321_02805 ENOG41060WC Enoyl-CoA hydratase BS1321_02815 ENOG4105EYH Exonuclease BS1321_02840 ENOG4105CUC YeeE YedE family protein BS1321_02855 ENOG4107QIV Cytochrome c biogenesis protein BS1321_02860 ENOG4108VGI doxx family BS1321_02870 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS1321_02875 ENOG4105K63 Thioredoxin BS1321_02905 ENOG4105VPS UPF0291 protein BS1321_02910 ENOG4108SVB resolvase BS1321_02920 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BS1321_02925 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BS1321_02950 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BS1321_02965 ENOG4108KN0 Choline kinase BS1321_02980 ENOG4107E54 Small Multidrug Resistance protein BS1321_02985 ENOG4107414 GntR family transcriptional regulator BS1321_02990 ENOG4105CG3 alpha amylase, catalytic region BS1321_02995 ENOG4105C5Y PTS System BS1321_03010 ENOG4105F1N DNA alkylation repair BS1321_03015 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family BS1321_03030 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BS1321_03040 ENOG4107QM2 Aldo Keto reductase BS1321_03045 ENOG4105VCP PTS System BS1321_03050 ENOG4105VZJ PTS System BS1321_03065 ENOG4105CK1 PTS System BS1321_03080 ENOG4107RGD Major Facilitator superfamily BS1321_03085 ENOG4108JUB Transcriptional regulator BS1321_03130 ENOG4105KAC Antibiotic biosynthesis monooxygenase BS1321_03135 ENOG4105KNA -acetyltransferase BS1321_03145 ENOG4108NHD germination protein BS1321_03150 ENOG4105E1K spore germination protein BS1321_03155 ENOG41088CQ domain protein BS1321_03160 ENOG4107Y9U Membrane BS1321_03165 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BS1321_03185 ENOG4105CT4 transporter BS1321_03190 ENOG4105D2H Uronic isomerase BS1321_03195 ENOG4105E2R ROK family BS1321_03205 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BS1321_03210 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS1321_03215 ENOG4107VQW regulatoR BS1321_03230 ENOG4107RCV ABC transporter, permease BS1321_03235 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS1321_03255 ENOG4105DKQ ROK family BS1321_03285 ENOG4105ETE Transcriptional regulator (LacI family BS1321_03290 ENOG4107YY3 extracellular solute-binding protein family 1 BS1321_03300 ENOG4105I1K ABC transporter BS1321_03305 ENOG4105CG3 alpha amylase, catalytic region BS1321_03320 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BS1321_03330 ENOG4105WH1 Two component transcriptional regulator luxr family BS1321_03350 ENOG4105C94 Transporter BS1321_03355 ENOG4105DVW rieske (2Fe-2S) BS1321_03365 ENOG4107TS3 membrane protein, TerC BS1321_03370 ENOG4108HWY Beta-lactamase BS1321_03405 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BS1321_03415 ENOG4105KPY Small multidrug resistance protein BS1321_03420 ENOG4105KPY Small multidrug resistance protein BS1321_03425 ENOG410667J hydrolase BS1321_03435 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS1321_03460 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BS1321_03480 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_03485 ENOG4107QNK )-transporter BS1321_03490 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BS1321_03495 ENOG4105CMG Carbohydrate kinase BS1321_03505 ENOG4105E2R ROK family BS1321_03535 ENOG4105ECR NmrA family BS1321_03540 ENOG4105KVH Transcriptional regulator BS1321_03570 ENOG4105T38 integral membrane protein BS1321_03590 ENOG4108J9Q DNA ligase BS1321_03605 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) BS1321_03610 ENOG4105C5F glutamine synthetase BS1321_03615 ENOG4105KV4 Transcriptional regulator BS1321_03620 ENOG4105CXI aluminum resistance protein BS1321_03625 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BS1321_03630 ENOG4105EN6 Membrane BS1321_03635 ENOG4106F1P AAA ATPase, central domain protein BS1321_03640 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BS1321_03645 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BS1321_03660 ENOG4105C19 ABC transporter BS1321_03665 ENOG4105EWM Histidine kinase BS1321_03705 ENOG4105F8D glycoside hydrolase family 4 BS1321_03710 ENOG4105VCP PTS System BS1321_03715 ENOG4105CK1 PTS System BS1321_03720 ENOG4105VZJ PTS System BS1321_03725 ENOG4108X79 transcriptional regulator BS1321_03730 ENOG4105CAQ asparagine synthetase BS1321_03750 ENOG4105EPD Oligopeptide transporter, Opt family BS1321_03760 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BS1321_03765 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BS1321_03780 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BS1321_03785 ENOG4105CPQ Dehydrogenase BS1321_03790 ENOG4105DQU oxidoreductase, subunit beta BS1321_03795 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein BS1321_03805 ENOG4105MCT stage V sporulation protein S BS1321_03810 ENOG4105D48 metallophosphoesterase BS1321_03820 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BS1321_03825 ENOG4105CEV competence damage-inducible protein BS1321_03830 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BS1321_03845 ENOG4105XZV Protein of unknown function (DUF3243) BS1321_03850 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BS1321_03870 ENOG4105UIB (ABC) transporter BS1321_03875 ENOG4108JQ9 ABC transporter BS1321_03880 ENOG4105DIH basic membrane BS1321_03885 ENOG4105FDP GntR family transcriptional regulator BS1321_03895 ENOG4105CNU cell division protein FtsK BS1321_03905 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BS1321_03915 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS1321_03925 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BS1321_03930 ENOG4108S0H Dipicolinic acid synthetase, b subunit BS1321_03935 ENOG4105E35 Dipicolinate synthase subunit A BS1321_03945 ENOG4105C1V Peptidase, M16 BS1321_03955 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BS1321_03960 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BS1321_03965 ENOG4105DTN riboflavin biosynthesis protein ribF BS1321_03970 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BS1321_03975 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BS1321_03980 ENOG4105W7A Protein of unknown function (DUF503) BS1321_03985 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BS1321_03990 ENOG4105VHM ribosomal protein BS1321_03995 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BS1321_04000 ENOG4105CHV Transcription elongation factor NusA BS1321_04005 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BS1321_04010 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BS1321_04020 ENOG4105DZP Membrane-associated zinc metalloprotease BS1321_04030 ENOG4105KNE Phosphatidate cytidylyltransferase BS1321_04035 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BS1321_04055 ENOG4105CE9 30S ribosomal protein S2 BS1321_04065 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_04070 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BS1321_04080 ENOG4108V3W Chemotaxis protein, CheW BS1321_04085 ENOG4105CBS Chea signal transduction histidine kinase BS1321_04100 ENOG4105FZW flagellar biosynthesis regulator FlhF BS1321_04105 ENOG4105D7B Flagellar biosynthesis protein flha BS1321_04110 ENOG4105D00 flagellar biosynthetic protein flhB BS1321_04115 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BS1321_04120 ENOG4105VS8 Flagellar biosynthetic protein fliq BS1321_04125 ENOG4105CN7 Flagellar biosynthetic protein FliP BS1321_04135 ENOG4107YTP response regulator receiver protein BS1321_04140 ENOG4105DD5 Flagellar motor switch protein BS1321_04145 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BS1321_04155 ENOG41068WV flagellar FlbD family protein BS1321_04160 ENOG4105BZE flagellar hook protein, FlgE BS1321_04170 ENOG410822I Flagellar hook capping protein BS1321_04185 ENOG4106YF4 Flagellar biosynthesis chaperone BS1321_04200 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BS1321_04205 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BS1321_04210 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BS1321_04215 ENOG4108ZC9 flagellar basal-body rod protein flgc BS1321_04220 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BS1321_04225 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) BS1321_04230 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BS1321_04240 ENOG4108HE4 integrase family BS1321_04250 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BS1321_04255 ENOG4105C79 DNA protecting protein DprA BS1321_04260 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BS1321_04265 ENOG4105CMV Succinyl-CoA synthetase subunit beta BS1321_04270 ENOG4105D00 flagellar biosynthetic protein flhB BS1321_04280 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BS1321_04285 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BS1321_04295 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BS1321_04300 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BS1321_04305 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BS1321_04315 ENOG4105VB6 UPF0109 protein BS1321_04320 ENOG4105K5M 30s ribosomal protein S16 BS1321_04335 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BS1321_04340 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BS1321_04345 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BS1321_04350 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BS1321_04355 ENOG4105CHR reductase BS1321_04360 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BS1321_04370 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BS1321_04375 ENOG4105CB5 ATP-dependent DNA helicase recG BS1321_04380 ENOG4105EJQ L-serine dehydratase BS1321_04390 ENOG4105DP4 dak2 domain fusion protein ylov BS1321_04395 ENOG4108ZAA Alkaline-shock protein BS1321_04400 ENOG4105VB9 50S ribosomal protein l28 BS1321_04410 ENOG4105FJ0 thiamine BS1321_04415 ENOG4105DJV ribulose-phosphate 3-epimerase BS1321_04420 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BS1321_04425 ENOG4105D9P serine threonine protein kinase BS1321_04430 ENOG4108ZF3 Phosphatase BS1321_04435 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BS1321_04440 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BS1321_04445 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BS1321_04455 ENOG4105C25 Primosomal protein n' BS1321_04460 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BS1321_04475 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BS1321_04485 ENOG4105DSJ YicC domain protein BS1321_04495 ENOG4105F23 Fibronectin-binding protein BS1321_04500 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BS1321_04510 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BS1321_04515 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BS1321_04520 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BS1321_04525 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BS1321_04535 ENOG4105CXT aspartate transcarbamylase BS1321_04545 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BS1321_04550 ENOG4105C34 Pseudouridine synthase BS1321_04555 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BS1321_04570 ENOG4105DBK s4 domain protein BS1321_04575 ENOG41067XK integral membrane protein BS1321_04580 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BS1321_04585 ENOG4105DFA alanine racemase domain protein BS1321_04590 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BS1321_04595 ENOG4105WR5 sporulation protein, YlmC YmxH family BS1321_04605 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_04610 ENOG4108AWX Sporulation factor SpoIIGA BS1321_04615 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BS1321_04620 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BS1321_04625 ENOG4105K67 small basic protein BS1321_04635 ENOG4108R2U division initiation protein BS1321_04640 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BS1321_04645 ENOG4105D4A Cell wall formation (By similarity) BS1321_04650 ENOG4105CNI cell division protein FtsW BS1321_04655 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BS1321_04660 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BS1321_04665 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BS1321_04670 ENOG4105CJN penicillin-binding protein BS1321_04675 ENOG4105CJN penicillin-binding protein BS1321_04690 ENOG4108V6E Cell division protein mraZ BS1321_04695 ENOG41074B2 UPF0747 protein BS1321_04720 ENOG4105E39 Enoyl-CoA hydratase BS1321_04730 ENOG4105KNH Nucleic acid-binding protein BS1321_04735 ENOG4105CDE UPF0348 protein BS1321_04740 ENOG41063PX domain protein BS1321_04745 ENOG4105D78 K07001 NTE family protein BS1321_04750 ENOG4105H20 Sporulation integral membrane protein YlbJ BS1321_04755 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BS1321_04760 ENOG4106H78 methyltransferase BS1321_04805 ENOG4106UY4 Inherit from COG: Scp-like extracellular BS1321_04845 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BS1321_04850 ENOG4107SGF Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity) BS1321_04855 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BS1321_04870 ENOG4108IAB Phoh family BS1321_04890 ENOG4105QA2 BS1321_04895 ENOG4105CI3 gtp-binding protein typa BS1321_04905 ENOG4105ECY inositol monophosphatase BS1321_04935 ENOG4105DK0 Indole-3-glycerol phosphate synthase BS1321_04940 ENOG4108I0Q anthranilate phosphoribosyltransferase BS1321_04945 ENOG4105DDQ anthranilate synthase BS1321_04950 ENOG4105CRQ synthase (Component I) BS1321_04955 ENOG4105WBI UPF0223 protein BS1321_04960 ENOG4105EA8 2-Nitropropane dioxygenase BS1321_04965 ENOG4105CXN decarboxylase BS1321_04975 ENOG4108ZJ4 polysaccharide deacetylase BS1321_04990 ENOG4105C7S Dehydrogenase BS1321_04995 ENOG4105CPP Dehydrogenase, E1 component BS1321_05020 ENOG4108X4Q Hydrolase BS1321_05025 ENOG4106EHS UPF0356 protein BS1321_05030 ENOG4105CN5 Metallo-Beta-Lactamase BS1321_05035 ENOG4107ZYR domain protein BS1321_05040 ENOG4105CH2 amidohydrolase BS1321_05045 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) BS1321_05060 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_05070 ENOG4107IN1 Protein of unknown function (DUF1797) BS1321_05095 ENOG4105EPM Diguanylate phosphodiesterase BS1321_05100 ENOG4107QWE )-transporter BS1321_05110 ENOG4105WMR Protein CrcB homolog BS1321_05125 ENOG4105UIN BS1321_05130 ENOG4107R88 Chemotaxis protein (CheV) BS1321_05135 ENOG4105D7N magnesium and cobalt transport protein CorA BS1321_05140 ENOG4105CHM Aminotransferase BS1321_05150 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BS1321_05155 ENOG4105CHR reductase BS1321_05160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BS1321_05165 ENOG4105KRI phosphocarrier protein (HPr BS1321_05170 ENOG4105C4B ABC transporter, permease BS1321_05175 ENOG4108T5I Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BS1321_05180 ENOG4107Y9E nuclease BS1321_05205 ENOG4108K88 Membrane BS1321_05210 ENOG4105DPN Oligoendopeptidase f BS1321_05215 ENOG41090MY MarR family Transcriptional regulator BS1321_05220 ENOG4105BZU Histidine kinase BS1321_05225 ENOG4105EU0 Major facilitator Superfamily BS1321_05240 ENOG4105BZU Histidine kinase BS1321_05245 ENOG4108TGC Acyltransferase BS1321_05260 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BS1321_05265 ENOG4105E39 Enoyl-CoA hydratase BS1321_05270 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BS1321_05290 ENOG4105E39 Enoyl-CoA hydratase BS1321_05295 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BS1321_05305 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_05310 ENOG4105CHR reductase BS1321_05315 ENOG4105C1G acyl-Coa dehydrogenase BS1321_05320 ENOG4105BZU Histidine kinase BS1321_05340 ENOG4108WZW RNA polymerase sigma BS1321_05345 ENOG4107TS3 membrane protein, TerC BS1321_05355 ENOG4105CNI cell division protein FtsW BS1321_05360 ENOG4105DFD Na H antiporter BS1321_05365 ENOG4107TT2 Auxin Efflux Carrier BS1321_05370 ENOG4105C6K Malic enzyme BS1321_05375 ENOG4108MRH transcriptional regulatory protein BS1321_05390 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BS1321_05405 ENOG4105DVE abc transporter atp-binding protein BS1321_05410 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BS1321_05425 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS1321_05450 ENOG4105D9M gamma-glutamylcysteine synthetase BS1321_05460 ENOG410606W general stress protein BS1321_05465 ENOG4105DER m42 family BS1321_05475 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BS1321_05480 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS1321_05485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS1321_05490 ENOG4108JQ7 (ABC) transporter BS1321_05500 ENOG4106I4J membrane BS1321_05505 ENOG4108S4H thioesterase Superfamily protein BS1321_05515 ENOG4106DF1 BS1321_05520 ENOG4105BZ1 (ABC) transporter BS1321_05530 ENOG4107TCE N-acetyltransferase BS1321_05545 ENOG4105ETU transcriptional activator (TenA BS1321_05555 ENOG4105DWF phosphomethylpyrimidine kinase BS1321_05560 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BS1321_05565 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BS1321_05570 ENOG41079KZ Major Facilitator Superfamily BS1321_05575 ENOG4105C26 Dehydrogenase BS1321_05585 ENOG4105VEQ Cold shock protein BS1321_05610 ENOG4105D5Q Arginine ornithine antiporter BS1321_05615 ENOG4108N2V aldose 1-epimerase BS1321_05640 ENOG4105ECW sulfate abc transporter BS1321_05645 ENOG4108I5D sulfate abc transporter BS1321_05650 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BS1321_05655 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BS1321_05660 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BS1321_05665 ENOG4105C85 amino acid BS1321_05670 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BS1321_05675 ENOG4105EBR Carboxylesterase BS1321_05685 ENOG4105CHH sulfate transporter BS1321_05690 ENOG4105CS2 ec 3.2.1.21 BS1321_05695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS1321_05705 ENOG4105EE0 oxidoreductase BS1321_05710 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BS1321_05715 ENOG4105C2C drug resistance transporter, Bcr CflA BS1321_05720 ENOG4105C5I Dehydrogenase BS1321_05725 ENOG41069FQ Metallo-beta-lactamase superfamily BS1321_05750 ENOG4105C1G acyl-Coa dehydrogenase BS1321_05755 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F BS1321_05760 ENOG4105SFS phosphoesterase RecJ domain protein BS1321_05785 ENOG4105H67 Protein of unknown function (DUF421) BS1321_05790 ENOG4108Z0Z intracellular protease Pfpi family BS1321_05825 ENOG4108W5N phosphatidylglycerophosphatase a BS1321_05835 ENOG4108ZMI UPF0477 protein BS1321_05860 ENOG4105ENA helicase BS1321_05875 ENOG4105CZ3 stage V sporulation protein ad BS1321_05880 ENOG41090VF Stage v sporulation protein ac BS1321_05910 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BS1321_05915 ENOG4105CJW magnesium transporter BS1321_05925 ENOG4105EMS pseudouridine synthase BS1321_05930 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BS1321_05940 ENOG4105MIX Adenylate cyclase BS1321_05945 ENOG4105E4C Lytic transglycosylase catalytic BS1321_05950 ENOG4108Z18 K06886 hemoglobin BS1321_05955 ENOG4105T58 Dithiol-disulfide isomerase BS1321_05965 ENOG4105DPN Oligoendopeptidase f BS1321_05975 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS1321_05980 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BS1321_05985 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BS1321_06010 ENOG4105C31 Tryptophanyl-tRNA synthetase BS1321_06015 ENOG4108KU1 UPF0736 protein BS1321_06025 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BS1321_06030 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BS1321_06060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BS1321_06065 ENOG4105MSY salicylate hydroxylase BS1321_06080 ENOG4105ERH Fumarylacetoacetate hydrolase BS1321_06095 ENOG4105DBV ornithine carbamoyltransferase BS1321_06105 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BS1321_06115 ENOG4105CAS nag kinase BS1321_06120 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) BS1321_06125 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BS1321_06130 ENOG4107V6Q Cyclic nucleotide-binding domain BS1321_06135 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BS1321_06140 ENOG4105VG1 fes assembly suf system protein BS1321_06145 ENOG4108MXZ Esterase BS1321_06150 ENOG4108KP7 hydrolase BS1321_06160 ENOG4105QVS general stress protein BS1321_06165 ENOG4107AYK membrAne BS1321_06170 ENOG4105EPR degv family BS1321_06175 ENOG4108VPT UPF0234 protein BS1321_06185 ENOG4105C5X domain protein BS1321_06190 ENOG4105FKQ transcriptional regulator BS1321_06200 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BS1321_06205 ENOG4107FKK extracellular solute-binding protein family 1 BS1321_06215 ENOG4105CAQ asparagine synthetase BS1321_06225 ENOG4105YHS UPF0344 protein BS1321_06235 ENOG4105DCM major facilitator superfamily BS1321_06300 ENOG41060YP BS1321_06310 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BS1321_06320 ENOG4105XVF Competence transcription factor BS1321_06330 ENOG4107AYK membrAne BS1321_06335 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BS1321_06350 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_06355 ENOG4105DF9 Lipoate-protein, ligase BS1321_06360 ENOG4108RQ5 Beta-lactamase domain-containing protein BS1321_06365 ENOG4106AXD BS1321_06375 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BS1321_06380 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BS1321_06385 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BS1321_06390 ENOG4105YVM Phosphoesterase, PA-phosphatase related BS1321_06415 ENOG4105K59 histidine triad (HIT) protein BS1321_06420 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BS1321_06425 ENOG4105NBU tryptophan transport protein BS1321_06440 ENOG41088ZC Negative regulator of protease production and sporulation (By similarity) BS1321_06465 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BS1321_06475 ENOG4105EQI Metal Dependent Phosphohydrolase BS1321_06485 ENOG4105E0A ABC, transporter BS1321_06495 ENOG4106D4I domain protein BS1321_06500 ENOG4107VRP DNA repair exonuclease BS1321_06505 ENOG4105C6T cysteine synthase BS1321_06515 ENOG4105CGU Enoyl-CoA hydratase BS1321_06520 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_06530 ENOG4107TUM Amidinotransferase BS1321_06575 ENOG4105KI2 Urea amidohydrolase subunit beta BS1321_06600 ENOG4105WZB UPF0342 protein BS1321_06615 ENOG410839P BS1321_06625 ENOG410839P BS1321_06630 ENOG410839P BS1321_06660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BS1321_06665 ENOG4108UMI ABC transporter, permease BS1321_06670 ENOG4105D01 (LipO)protein BS1321_06675 ENOG4107SCQ Iron-containing alcohol dehydrogenase BS1321_06700 ENOG4105C9Q fumarate hydratase class II BS1321_06705 ENOG4105C28 cystathionine BS1321_06710 ENOG4105C28 cystathionine BS1321_06715 ENOG4105NRA 50s ribosomal protein l31 type b BS1321_06720 ENOG4105BZ1 (ABC) transporter BS1321_06725 ENOG4105BZ1 (ABC) transporter BS1321_06740 ENOG4107RF6 penicillin-binding protein BS1321_06745 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BS1321_06750 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BS1321_06765 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BS1321_06780 ENOG4107VGR Catalase BS1321_06800 ENOG4105CIH Imidazole acetol-phosphate transaminase BS1321_06815 ENOG4105C7S Dehydrogenase BS1321_06820 ENOG4105CPP Dehydrogenase, E1 component BS1321_06835 ENOG4105DYB Isoaspartyl dipeptidase BS1321_06845 ENOG4105BZ4 penicillin-binding protein BS1321_06860 ENOG4105BZU Histidine kinase BS1321_06865 ENOG4105C37 (CBS) domain BS1321_06870 ENOG4107T5V SNARE associated Golgi BS1321_06880 ENOG4108JYZ YitT family BS1321_06885 ENOG4105C37 (CBS) domain BS1321_06890 ENOG4108REF Sporulation integral membrane protein ytvi BS1321_06905 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_06915 ENOG4108W0I acetyltransferase BS1321_06925 ENOG4105C72 UPF0176 protein BS1321_06935 ENOG4105D4T Citrate transporter BS1321_06945 ENOG4105CSP Major Facilitator Superfamily BS1321_06955 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_06960 ENOG4105CHU acetyl-coa acetyltransferase BS1321_06965 ENOG4105E39 Enoyl-CoA hydratase BS1321_06970 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BS1321_06975 ENOG4105C1G acyl-Coa dehydrogenase BS1321_06990 ENOG4105CHH sulfate transporter BS1321_06995 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BS1321_07000 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS1321_07005 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS1321_07015 ENOG4105VEQ Cold shock protein BS1321_07030 ENOG4105E0C molybdate abc transporter BS1321_07035 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BS1321_07040 ENOG4105BZU Histidine kinase BS1321_07050 ENOG4105PGM cation diffusion facilitator family transporter BS1321_07070 ENOG4108Z0R Transferase BS1321_07075 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein BS1321_07080 ENOG4105E39 Enoyl-CoA hydratase BS1321_07085 ENOG4105CHU acetyl-coa acetyltransferase BS1321_07090 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BS1321_07095 ENOG4105C26 Dehydrogenase BS1321_07100 ENOG4105CGU Enoyl-CoA hydratase BS1321_07105 ENOG4105E39 Enoyl-CoA hydratase BS1321_07130 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BS1321_07140 ENOG4105DZS Phenylacetate-CoA ligase BS1321_07160 ENOG4105CD3 dihydroorotase BS1321_07165 ENOG4105C5R Aminotransferase BS1321_07180 ENOG4105G9B Transcriptional regulator BS1321_07190 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) BS1321_07215 ENOG4105EFA 4-hydroxyphenylacetate BS1321_07240 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS1321_07245 ENOG4105CAH Chromate BS1321_07250 ENOG4105FGV Chromate BS1321_07260 ENOG4105GR3 Histidine kinase BS1321_07265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_07270 ENOG41080BT SNARE associated Golgi BS1321_07285 ENOG4105D2S major facilitator superfamily BS1321_07295 ENOG4105J4Q Transcriptional regulator BS1321_07300 ENOG4105D7K pfkb domain protein BS1321_07305 ENOG4108UHU Aldolase BS1321_07310 ENOG4105CXK mandelate racemase muconate lactonizing BS1321_07315 ENOG4105DJB Major Facilitator Superfamily BS1321_07405 ENOG4105JVQ RNA Polymerase BS1321_07420 ENOG4105EKQ RNA-directed DNA polymerase BS1321_07430 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BS1321_07435 ENOG4108UXE Protein tyrosine phosphatase BS1321_07440 ENOG4107R5R arsenical pump membrane protein BS1321_07445 ENOG41082YX Transcriptional regulator, arsr family BS1321_07455 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BS1321_07490 ENOG4105ED1 spovr family BS1321_07495 ENOG4108K88 Membrane BS1321_07500 ENOG4105DTQ mandelate racemase muconate lactonizing BS1321_07520 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BS1321_07550 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BS1321_07570 ENOG4108YBP pseudouridine synthase BS1321_07575 ENOG4107BMA Transglycosylase associated protein BS1321_07585 ENOG4105CJ3 phosphate transporter BS1321_07590 ENOG4107GRR phosphate transport regulator BS1321_07595 ENOG4105CJ3 phosphate transporter BS1321_07600 ENOG4108K8K Transcriptional regulator BS1321_07605 ENOG4105EU9 BS1321_07610 ENOG4105DCF alanine dehydrogenase BS1321_07615 ENOG4105CQB FAD linked oxidase domain protein BS1321_07620 ENOG4105II7 pyrroline-5-carboxylate reductase BS1321_07625 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_07630 ENOG4108VX5 3-methyladenine DNA glycosylase BS1321_07635 ENOG4108PJD permease BS1321_07655 ENOG4107RA9 decarboxylase BS1321_07665 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BS1321_07695 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BS1321_07700 ENOG4105CSC Glucose uptake protein BS1321_07730 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS1321_07745 ENOG41073TP transcriptional regulator BS1321_07750 ENOG4105DJ2 Major Facilitator Superfamily BS1321_07765 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BS1321_07775 ENOG4105D3Q Sugar transferase BS1321_07785 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BS1321_07790 ENOG4107YJ4 chain length determinant protein BS1321_07800 ENOG4107QQG Dehydrogenase BS1321_07840 ENOG4105CYN Serine protein kinase BS1321_07845 ENOG4107QTZ amino acid BS1321_07850 ENOG4105CSV Glutaminase BS1321_07865 ENOG4105EHG Permease protein BS1321_07870 ENOG4105DQ5 transport system permease protein BS1321_07880 ENOG4105E0A ABC, transporter BS1321_07885 ENOG4108DBC nitroreductase BS1321_07890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BS1321_07900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BS1321_07925 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BS1321_07930 ENOG4105CJW magnesium transporter BS1321_07940 ENOG4105E1V na solute symporter BS1321_07945 ENOG4106CAD Protein of unknown function (DUF3311) BS1321_07985 ENOG4105C26 Dehydrogenase BS1321_07990 ENOG4105MWK D-amino acid dehydrogenase, small subunit BS1321_08005 ENOG4108SUT Major Facilitator Superfamily BS1321_08015 ENOG4105CFC Transporter BS1321_08025 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BS1321_08035 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS1321_08040 ENOG4105D7V transposase BS1321_08045 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_08050 ENOG4105J7D transcriptional regulator BS1321_08080 ENOG4105ETE Transcriptional regulator (LacI family BS1321_08090 ENOG4105D2N Aldolase BS1321_08095 ENOG4107VG4 Xylose isomerase domain protein TIM barrel BS1321_08100 ENOG4105F0H myo-inositol catabolism protein BS1321_08105 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BS1321_08110 ENOG4107QNK )-transporter BS1321_08115 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BS1321_08120 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) BS1321_08125 ENOG4105D7K pfkb domain protein BS1321_08130 ENOG4105DH8 myo-inositol catabolism BS1321_08145 ENOG4105CSH Transporter BS1321_08150 ENOG4105PAD Hydrolase BS1321_08155 ENOG4105E1V na solute symporter BS1321_08170 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS1321_08180 ENOG4105DVW rieske (2Fe-2S) BS1321_08195 ENOG4108JUB Transcriptional regulator BS1321_08205 ENOG4105K6V RNA polymerase BS1321_08215 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BS1321_08220 ENOG4108Q8B Spore germination protein BS1321_08240 ENOG4105E1K spore germination protein BS1321_08245 ENOG4105EEQ Na H antiporter BS1321_08295 ENOG41090UD (LipO)protein BS1321_08320 ENOG4105WEF catalase BS1321_08345 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BS1321_08350 ENOG4105U0R haloacid dehalogenase-like hydrolase BS1321_08365 ENOG4105E2A Dehydrogenase BS1321_08370 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BS1321_08375 ENOG4108HGU Histidine kinase BS1321_08390 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BS1321_08410 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BS1321_08435 ENOG4105CSV Glutaminase BS1321_08450 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS1321_08550 ENOG4105TUA UPF0295 protein BS1321_08555 ENOG4105G5W regulator Fur family BS1321_08570 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS1321_08585 ENOG4108S4H thioesterase Superfamily protein BS1321_08600 ENOG4108IUW ABC transporter BS1321_08610 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BS1321_08615 ENOG4105CBC glutamate synthase BS1321_08620 ENOG4107NBY Membrane BS1321_08630 ENOG4105CW7 secretion protein, HlyD family BS1321_08635 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_08640 ENOG4105CS1 NAD(P)H quinone oxidoreductase BS1321_08655 ENOG4105BZ1 (ABC) transporter BS1321_08660 ENOG4105EVI UPF0374 protein BS1321_08675 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BS1321_08680 ENOG4106BXE BS1321_08690 ENOG4105CEN a g-specific adenine glycosylase BS1321_08695 ENOG41067AE Membrane-bound metal-dependent hydrolase BS1321_08705 ENOG4105XHU Acid-soluble spore protein K BS1321_08715 ENOG410902V Modulates RecA activity (By similarity) BS1321_08720 ENOG4105ECP epimerase BS1321_08735 ENOG4105CHU acetyl-coa acetyltransferase BS1321_08740 ENOG4105C1G acyl-Coa dehydrogenase BS1321_08760 ENOG4105CMU LysR family (Transcriptional regulator BS1321_08770 ENOG4105CDA abc transporter atp-binding protein BS1321_08775 ENOG4105E5Q amino acid AbC transporter BS1321_08780 ENOG4106PMH Extracellular solute-binding protein family 3 BS1321_08785 ENOG4106F5Q Membrane BS1321_08805 ENOG4105CZM Major Facilitator BS1321_08810 ENOG4105BZU Histidine kinase BS1321_08830 ENOG4105K7K Transcriptional regulator BS1321_08855 ENOG4107T0D ABC, transporter BS1321_08865 ENOG4105CHM Aminotransferase BS1321_08905 ENOG4105DRP amino acid AbC transporter BS1321_08910 ENOG4105CDA abc transporter atp-binding protein BS1321_08920 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS1321_08935 ENOG4108HVR ABC transporter, permease BS1321_08940 ENOG4105C19 ABC transporter BS1321_08965 ENOG4105DA5 (ABC) transporter BS1321_08990 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BS1321_08995 ENOG4105CPU Monooxygenase BS1321_09005 ENOG4108UMI ABC transporter, permease BS1321_09015 ENOG4105D01 (LipO)protein BS1321_09020 ENOG4105DEN Luciferase family BS1321_09025 ENOG4105CH2 amidohydrolase BS1321_09030 ENOG4108R6G acetyltransferase BS1321_09035 ENOG4105CDA abc transporter atp-binding protein BS1321_09055 ENOG4108XSB acetyltransferase, (GNAT) family BS1321_09070 ENOG4105DEN Luciferase family BS1321_09085 ENOG4105DNP FAD linked oxidase domain protein BS1321_09095 ENOG4105C85 amino acid BS1321_09105 ENOG4105E1V na solute symporter BS1321_09115 ENOG4106IQC argininosuccinate lyase BS1321_09120 ENOG4108I5D sulfate abc transporter BS1321_09125 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS1321_09145 ENOG4105CDA abc transporter atp-binding protein BS1321_09150 ENOG4105E5Q amino acid AbC transporter BS1321_09155 ENOG4107R0W ABC transporter BS1321_09160 ENOG4108JQ7 (ABC) transporter BS1321_09170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS1321_09175 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS1321_09180 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein BS1321_09185 ENOG4105DWD nucleoside recognition domain protein BS1321_09195 ENOG4105DWT malate dehydrogenase (quinone) BS1321_09200 ENOG4105CS9 pantothenic acid kinase BS1321_09235 ENOG4108W15 Protein of unknown function (DUF1456) BS1321_09240 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BS1321_09280 ENOG4105UPD Calcium Proton BS1321_09285 ENOG4108ISG Major Facilitator BS1321_09290 ENOG4105C59 p-type ATPase BS1321_09295 ENOG4107U9T Pfam:Ribonuclease_BN BS1321_09305 ENOG41068PA UPF0435 protein BS1321_09310 ENOG4105CVM Molybdenum cofactor synthesis domain protein BS1321_09315 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b BS1321_09325 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BS1321_09330 ENOG4107RKG DJ-1/PfpI family BS1321_09340 ENOG4105ER2 Ompa motb domain protein BS1321_09345 ENOG4105E14 MotA TolQ exbB proton channel BS1321_09350 ENOG4108KK1 membrane protein AbrB duplication BS1321_09365 ENOG4105NCW Trka-c domain protein BS1321_09370 ENOG4107S91 Sodium hydrogen exchanger BS1321_09380 ENOG4107U9T Pfam:Ribonuclease_BN BS1321_09400 ENOG4108R6K riboflavin synthase, subunit alpha BS1321_09410 ENOG4105C28 cystathionine BS1321_09415 ENOG4108594 Permease of the drug metabolite transporter BS1321_09420 ENOG4105FDU atp-dependent rna helicase BS1321_09425 ENOG4105BZU Histidine kinase BS1321_09430 ENOG4105CK7 Sodium proline symporter BS1321_09435 ENOG4108J2R molybdopterin oxidoreductase BS1321_09445 ENOG4105C26 Dehydrogenase BS1321_09455 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS1321_09460 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_09465 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase BS1321_09475 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BS1321_09490 ENOG4105C8Q Methyl-accepting chemotaxis BS1321_09495 ENOG4107KM7 Heat induced stress protein YflT BS1321_09505 ENOG41069ER domain protein BS1321_09510 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BS1321_09515 ENOG4107QJT sodium dicarboxylate symporter BS1321_09520 ENOG4105C26 Dehydrogenase BS1321_09525 ENOG4105C02 permease BS1321_09530 ENOG4105CYC Transferase BS1321_09535 ENOG4105DY9 regulatoR BS1321_09550 ENOG4105BZU Histidine kinase BS1321_09555 ENOG4105VCD cytoplasmic protein BS1321_09560 ENOG4105D22 carbon starvation protein BS1321_09565 ENOG4105BZ1 (ABC) transporter BS1321_09570 ENOG4105BZ1 (ABC) transporter BS1321_09575 ENOG4107Y03 Nitroreductase BS1321_09580 ENOG4105CFH Aspartokinase BS1321_09585 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BS1321_09610 ENOG4105CCU oxidase (Subunit III) BS1321_09620 ENOG4105E2S oxidase) subunit II BS1321_09630 ENOG4105C0H protease BS1321_09645 ENOG41067QW Transcriptional regulator BS1321_09655 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BS1321_09665 ENOG4105KVH Transcriptional regulator BS1321_09670 ENOG4105CNN ABC, transporter BS1321_09675 ENOG4105C2J ABC transporter BS1321_09695 ENOG4105CPC Aldo Keto reductase BS1321_09700 ENOG4108IPJ Membrane BS1321_09705 ENOG4105FE9 pseudouridine synthase BS1321_09715 ENOG4105CK5 oxidoreductase BS1321_09730 ENOG4105FKQ transcriptional regulator BS1321_09755 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BS1321_09765 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BS1321_09775 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) BS1321_09780 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) BS1321_09785 ENOG4105BZU Histidine kinase BS1321_09795 ENOG4105C09 Bile acid BS1321_09800 ENOG4106BRA Membrane BS1321_09835 ENOG41065RQ ADP-ribosylation crystallin J1 BS1321_09870 ENOG4105IIU Aminopeptidase BS1321_09880 ENOG4105BZU Histidine kinase BS1321_09885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BS1321_09905 ENOG4108UIN ybak prolyl-trna synthetase associated region BS1321_09910 ENOG410807C QueT transporter BS1321_09920 ENOG4105BZU Histidine kinase BS1321_09930 ENOG4108T5E Copper resistance protein BS1321_09935 ENOG4105KTB nuclear export factor GLE1 BS1321_09945 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BS1321_09950 ENOG41069NU Nitroreductase BS1321_09955 ENOG4105CDW Resistance protein BS1321_10000 ENOG4105CZ3 stage V sporulation protein ad BS1321_10010 ENOG4108QY0 Membrane BS1321_10015 ENOG4108JYZ YitT family BS1321_10020 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BS1321_10030 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) BS1321_10035 ENOG4105CBD Diacylglycerol kinase BS1321_10055 ENOG4105DU6 RNA polymerase BS1321_10060 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BS1321_10065 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BS1321_10070 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BS1321_10080 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BS1321_10085 ENOG4105C4R Atp-dependent dna helicase BS1321_10090 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) BS1321_10095 ENOG4105KGF protein, YerC YecD BS1321_10100 ENOG4108R5T secreted protein BS1321_10115 ENOG4105C12 Phosphoribosylglycinamide synthetase BS1321_10120 ENOG4105DC1 bifunctional purine biosynthesis protein purh BS1321_10125 ENOG4108V3E phosphoribosylglycinamide formyltransferase BS1321_10145 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BS1321_10150 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BS1321_10160 ENOG4105C83 adenylosuccinate lyase BS1321_10165 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BS1321_10170 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BS1321_10195 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BS1321_10200 ENOG4105ETE Transcriptional regulator (LacI family BS1321_10210 ENOG4105E2X shikimate dehydrogenase BS1321_10215 ENOG4105FF2 Type I DHQase BS1321_10245 ENOG4105CID antiterminator BS1321_10250 ENOG4105C7N Xanthine uracil vitamin C permease BS1321_10255 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BS1321_10270 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BS1321_10280 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BS1321_10295 ENOG4105EC2 ftsk spoIIIe BS1321_10330 ENOG4108IJ7 Glycine betaine BS1321_10335 ENOG4108IQI permease BS1321_10340 ENOG4105C84 Histidine ammonia-lyase BS1321_10345 ENOG4105U7G Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization (By similarity) BS1321_10365 ENOG4108Q8B Spore germination protein BS1321_10370 ENOG4108NHD germination protein BS1321_10390 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BS1321_10400 ENOG4105CMG Carbohydrate kinase BS1321_10435 ENOG4105D2N Aldolase BS1321_10455 ENOG4105ETD TRANSCRIPTIONal BS1321_10460 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS1321_10465 ENOG4105DJB Major Facilitator Superfamily BS1321_10480 ENOG4105JFG SpoIID LytB domain protein BS1321_10490 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BS1321_10500 ENOG4108TYN CAAX amino terminal protease family protein BS1321_10510 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BS1321_10520 ENOG4105C5H ABC transporter BS1321_10525 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BS1321_10530 ENOG410801F ribosomal-protein-alanine acetyltransferase BS1321_10535 ENOG41072GX Peptidase M22 Glycoprotease BS1321_10540 ENOG4105K8N protein family UPF0079, ATPase BS1321_10630 ENOG410906U SprT-like BS1321_10640 ENOG41064BQ Phosphatase BS1321_10650 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BS1321_10655 ENOG4105WN5 stage II sporulation protein BS1321_10660 ENOG4107SGM protein serine threonine phosphatase BS1321_10665 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BS1321_10670 ENOG4105FUA antagonist BS1321_10675 ENOG4107MMM Anti-sigma-factor antagonist BS1321_10680 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BS1321_10695 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BS1321_10700 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BS1321_10710 ENOG4105CKV Membrane BS1321_10715 ENOG410905X membrane-flanked domain protein BS1321_10720 ENOG4105C1J atp-dependent rna helicase BS1321_10725 ENOG4108MJI response regulator BS1321_10730 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BS1321_10735 ENOG4105CPF Cell wall formation (By similarity) BS1321_10765 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BS1321_10770 ENOG41067SE Tetr family transcriptional regulator BS1321_10780 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS1321_10830 ENOG4108MJI response regulator BS1321_10835 ENOG4105BZU Histidine kinase BS1321_10840 ENOG4105BZU Histidine kinase BS1321_10845 ENOG4105C37 (CBS) domain BS1321_10860 ENOG4107SJW iron permease, FTR1 BS1321_10865 ENOG4105DBE peroxidase BS1321_10870 ENOG410650H (LipO)protein BS1321_10890 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BS1321_10900 ENOG4105NIV Esterase BS1321_10920 ENOG4105E0A ABC, transporter BS1321_10925 ENOG4105CI1 PTS System BS1321_10930 ENOG4105CE4 GlcNAc 6-P deacetylase BS1321_10935 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BS1321_10940 ENOG4105FDP GntR family transcriptional regulator BS1321_10945 ENOG4108SU4 UPF0309 protein BS1321_10950 ENOG4105EYF MMPL domain protein BS1321_10965 ENOG41085KW ppic-type peptidyL-prolyl cis-trans isomerase BS1321_10970 ENOG4107RUE extracellular solute-binding protein family 1 BS1321_10975 ENOG4105D38 putrescine abc transporter BS1321_10980 ENOG4105F38 ABC transporter, permease BS1321_10985 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS1321_10995 ENOG4105C1Q protoporphyrinogen oxidase BS1321_11000 ENOG41080E2 ribosomal-protein-alanine acetyltransferase BS1321_11005 ENOG4107SUZ Sodium/hydrogen exchanger family BS1321_11010 ENOG4105CBD Diacylglycerol kinase BS1321_11015 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BS1321_11035 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BS1321_11045 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BS1321_11065 ENOG4105C8Q Methyl-accepting chemotaxis BS1321_11070 ENOG4105CPF Cell wall formation (By similarity) BS1321_11095 ENOG4105BZ1 (ABC) transporter BS1321_11105 ENOG4105BZU Histidine kinase BS1321_11110 ENOG4108ZMX Domain of unknown function (DU1801) BS1321_11115 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BS1321_11120 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BS1321_11125 ENOG4107U5W ybbr family BS1321_11130 ENOG4105C8B TIGR00159 family BS1321_11140 ENOG4105EMN RNA polymerase sigma factor BS1321_11220 ENOG4108NMV polysaccharide deacetylase BS1321_11235 ENOG4105D1F ATP-binding protein BS1321_11260 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_11265 ENOG4108UJD 30S ribosomal protein S9 BS1321_11270 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BS1321_11280 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BS1321_11285 ENOG4108JJB ABC transporter BS1321_11290 ENOG4108JJB ABC transporter BS1321_11295 ENOG4108ZT0 50S ribosomal protein l17 BS1321_11300 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS1321_11305 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BS1321_11320 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BS1321_11330 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BS1321_11335 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BS1321_11340 ENOG4105VPB 50S ribosomal protein L30 BS1321_11345 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BS1321_11350 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BS1321_11355 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BS1321_11360 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BS1321_11365 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BS1321_11375 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BS1321_11385 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BS1321_11390 ENOG41082SA 50s ribosomal protein l29 BS1321_11395 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BS1321_11400 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BS1321_11405 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BS1321_11410 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BS1321_11415 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BS1321_11420 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BS1321_11425 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BS1321_11430 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BS1321_11445 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BS1321_11450 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BS1321_11455 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BS1321_11460 ENOG4105XPM ribosomal protein BS1321_11465 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS1321_11470 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BS1321_11475 ENOG4107Y49 methyltransferase BS1321_11480 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BS1321_11490 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BS1321_11500 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BS1321_11510 ENOG4105QIV RNA polymerase BS1321_11515 ENOG4105M0M Tetracycline resistance protein BS1321_11520 ENOG4105C2N RNA methyltransferase TrmH family group 3 BS1321_11530 ENOG4105C8N cysteinyl-tRNA synthetase BS1321_11535 ENOG4105D7W serine acetyltransferase BS1321_11540 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BS1321_11545 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BS1321_11550 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BS1321_11555 ENOG4105CTP PilT protein domain protein BS1321_11560 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BS1321_11565 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BS1321_11575 ENOG41066A3 ATP guanido phosphotransferase BS1321_11580 ENOG4108Z0C Uvrb UvrC protein BS1321_11605 ENOG4105CRK lysyL-tRNA synthetase BS1321_11610 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BS1321_11620 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BS1321_11625 ENOG4105KRF dihydroneopterin aldolase BS1321_11630 ENOG4105EEI dihydropteroate synthase BS1321_11635 ENOG4105C6T cysteine synthase BS1321_11640 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BS1321_11645 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BS1321_11650 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BS1321_11660 ENOG4108UGV hypoxanthine phosphoribosyltransferase BS1321_11665 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BS1321_11695 ENOG41060GV RNA binding s1 domain protein BS1321_11710 ENOG4105VYY sporulation protein yabp BS1321_11715 ENOG41082I2 s4 domain protein BS1321_11720 ENOG4108IY2 MazG family BS1321_11730 ENOG4108M14 stage v sporulation protein t BS1321_11735 ENOG4108JA2 transcriptioN-repair coupling factor BS1321_11750 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BS1321_11755 ENOG4105E2Y ABC, transporter BS1321_11760 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BS1321_11765 ENOG4105FBW Monooxygenase BS1321_11770 ENOG4105GVF (ABC) transporter BS1321_11775 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BS1321_11780 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BS1321_11790 ENOG4105K4W Could be involved in septation (By similarity) BS1321_11795 ENOG4105KME endoribonuclease L-psp BS1321_11800 ENOG4105DFT pur operon repressor BS1321_11805 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BS1321_11815 ENOG4105W42 Veg protein BS1321_11820 ENOG4105XFA sporulation peptidase YabG BS1321_11825 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BS1321_11830 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) BS1321_11835 ENOG41069ER domain protein BS1321_11840 ENOG4105F8V Hydrolase, tatD family BS1321_11850 ENOG4105KRN Transcriptional regulator, abrb family BS1321_11855 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BS1321_11865 ENOG41060K3 Methyltransferase BS1321_11870 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) BS1321_11875 ENOG4105MA4 psp1 domain protein BS1321_11880 ENOG4105FA2 dna polymerase iii BS1321_11890 ENOG4105X0R protein from nitrogen regulatory protein P-II BS1321_11895 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BS1321_11900 ENOG4105CXN decarboxylase BS1321_11940 ENOG41067KS pro-sigma K processing BS1321_11950 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BS1321_11955 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BS1321_11960 ENOG4105C6E dna polymerase iii BS1321_11970 ENOG4108Z6B deaminase BS1321_11975 ENOG4105GTG Isochorismatase BS1321_11985 ENOG4105ZMH deoxynucleoside kinase BS1321_11995 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BS1321_12005 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BS1321_12045 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS1321_12050 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BS1321_12060 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BS1321_12065 ENOG410848D S4 domain protein YaaA BS1321_12070 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BS1321_12075 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BS1321_12085 ENOG4105VG0 50S ribosomal protein l34 BS1321_12090 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) BS1321_12095 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BS1321_12105 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BS1321_12110 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BS1321_12115 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BS1321_12120 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) BS1321_12125 ENOG4107QJE Chromosome Partitioning Protein BS1321_12130 ENOG4105FA0 parb-like partition protein BS1321_12140 ENOG4108ZDA Sporulation protein YyaC BS1321_12145 ENOG4105D8X mechanosensitive ion channel BS1321_12150 ENOG4105VDK protein, conserved in bacteria BS1321_12155 ENOG4105C3G gtp-binding protein BS1321_12160 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BS1321_12165 ENOG4108UUM single-stranded DNA-binding protein BS1321_12170 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BS1321_12180 ENOG4105BZR domain protein BS1321_12185 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BS1321_12190 ENOG4105CDU Replicative dna helicase BS1321_12195 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BS1321_12220 ENOG4105E4C Lytic transglycosylase catalytic BS1321_12225 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_12230 ENOG4105BZU Histidine kinase BS1321_12245 ENOG4105Q2H domain protein BS1321_12250 ENOG4105C0H protease BS1321_12260 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BS1321_12265 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BS1321_12275 ENOG4105C1J atp-dependent rna helicase BS1321_12280 ENOG4105CH6 catalase BS1321_12285 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BS1321_12315 ENOG4105DY8 decarboxylase BS1321_12340 ENOG4105ETE Transcriptional regulator (LacI family BS1321_12345 ENOG4108RVA ribokinase BS1321_12350 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BS1321_12355 ENOG4105C2J ABC transporter BS1321_12360 ENOG4105CNN ABC, transporter BS1321_12365 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BS1321_12370 ENOG4105D82 Glutamate dehydrogenase BS1321_12375 ENOG4105C5Q Transcriptional regulator BS1321_12385 ENOG4105DR4 Methyltransferase BS1321_12395 ENOG4105CK2 sodium dicarboxylate symporter BS1321_12400 ENOG4107YUH hydrolase BS1321_12430 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BS1321_12435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) BS1321_12440 ENOG4108STX response regulator BS1321_12445 ENOG4105GR3 Histidine kinase BS1321_12455 ENOG4105D9N nucleoside BS1321_12460 ENOG4105E0X reductase BS1321_12470 ENOG4105CX6 glutaminyL-tRNA synthetase BS1321_12480 ENOG4105E5Q amino acid AbC transporter BS1321_12485 ENOG4105EAB amino acid AbC transporter BS1321_12500 ENOG4105CIY formyltetrahydrofolate deformylase BS1321_12540 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BS1321_12550 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BS1321_12575 ENOG4105D7W serine acetyltransferase BS1321_12580 ENOG4105C7N Xanthine uracil vitamin C permease BS1321_12585 ENOG4105C1J atp-dependent rna helicase BS1321_12605 ENOG4105C5H ABC transporter BS1321_12610 ENOG4105C9U ATP-dependent DNA helicase RecQ BS1321_12620 ENOG4107BJW polysaccharide deacetylase BS1321_12625 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BS1321_12630 ENOG4105EHG Permease protein BS1321_12635 ENOG4105E0A ABC, transporter BS1321_12640 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BS1321_12645 ENOG4107QZB decarboxylase BS1321_12655 ENOG4107XPA Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) BS1321_12670 ENOG4108WBT adenosyltransferase BS1321_12685 ENOG4105C6Z Gluconate BS1321_12690 ENOG4105CMG Carbohydrate kinase BS1321_12695 ENOG4108Z66 YbaK ebsC protein BS1321_12705 ENOG4105J7I hydrolase BS1321_12710 ENOG4105D8V Glucose sorbosone dehydrogenase BS1321_12720 ENOG4107MII Sugar-specific transcriptional regulator TrmB BS1321_12725 ENOG4105CZM Major Facilitator BS1321_12730 ENOG4108TN2 lmbE family BS1321_12740 ENOG4105DWF phosphomethylpyrimidine kinase BS1321_12745 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BS1321_12750 ENOG4108ZAF Molybdopterin BS1321_12755 ENOG41067WU Molybdopterin converting factor (Subunit 1) BS1321_12760 ENOG4105D06 uba thif-type nad fad binding protein BS1321_12775 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BS1321_12800 ENOG4107JTW chlorite dismutase BS1321_12805 ENOG4108IJ2 phosphate acetyltransferase BS1321_12810 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BS1321_12820 ENOG4108VCI transcription factor, rsfa family BS1321_12830 ENOG4105DCI Phosphohydrolase BS1321_12840 ENOG41069HH 4-oxalocrotonate tautomerase BS1321_12845 ENOG4108Z4T Peptidase M50 BS1321_12850 ENOG4108XFG YwhD family BS1321_12855 ENOG4105BZ4 penicillin-binding protein BS1321_12860 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BS1321_12865 ENOG4105CYW agmatinase BS1321_12875 ENOG4105C75 arginyL-tRNA synthetase BS1321_12890 ENOG4105DF6 Fe-S oxidoreductase BS1321_12900 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BS1321_12905 ENOG4105C1G acyl-Coa dehydrogenase BS1321_12910 ENOG4105C1G acyl-Coa dehydrogenase BS1321_12920 ENOG4105D5P Methylmalonyl-coA mutase BS1321_12930 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BS1321_12940 ENOG410812K response regulator receiver protein BS1321_12950 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BS1321_12955 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BS1321_12960 ENOG4105CBT Fructose-1,6-bisphosphatase BS1321_12965 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BS1321_12970 ENOG4105VFB Binds the 23S rRNA (By similarity) BS1321_12975 ENOG4107104 thymidine kinase BS1321_12985 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BS1321_12990 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BS1321_12995 ENOG4108ZXQ stage ii sporulation protein r BS1321_13005 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BS1321_13010 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BS1321_13025 ENOG4108YZG isomerase BS1321_13030 ENOG4108UIC UPF0340 protein BS1321_13040 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BS1321_13045 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BS1321_13050 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BS1321_13060 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BS1321_13065 ENOG4105WS6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BS1321_13075 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BS1321_13080 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BS1321_13085 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BS1321_13090 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BS1321_13095 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BS1321_13100 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BS1321_13105 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BS1321_13110 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BS1321_13115 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BS1321_13125 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BS1321_13135 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BS1321_13140 ENOG4105D65 subunit l BS1321_13145 ENOG4105C8S subunit m BS1321_13150 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BS1321_13155 ENOG4106778 Protein of unknown function (DUF1146) BS1321_13180 ENOG4105FRN stage II sporulation protein BS1321_13185 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BS1321_13190 ENOG4105DFF Rod shape-determining protein mreb BS1321_13200 ENOG4105CGA flagellar basal-body rod protein FlgG BS1321_13225 ENOG4105Z8H single-stranded DNA-binding protein BS1321_13230 ENOG4105C3U ABC transporter BS1321_13235 ENOG4108JQ7 (ABC) transporter BS1321_13240 ENOG4105DEF Extracellular solute-binding protein, family 5 BS1321_13245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS1321_13250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS1321_13265 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_13270 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BS1321_13275 ENOG4105C0D helicase BS1321_13280 ENOG4105KBK Zinc finger, swim domain protein BS1321_13305 ENOG4107RVG penicillin-binding protein BS1321_13315 ENOG4105JFG SpoIID LytB domain protein BS1321_13320 ENOG4105G6Z alkaline phosphatase BS1321_13325 ENOG4106KBF Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane (By similarity) BS1321_13340 ENOG4105E0M Sulfatase BS1321_13345 ENOG4108KGH TRANSCRIPTIONal BS1321_13355 ENOG4107RZX Teichoic acid biosynthesis protein BS1321_13360 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BS1321_13365 ENOG4107SJB teichoic acid biosynthesis BS1321_13375 ENOG4107SJB teichoic acid biosynthesis BS1321_13385 ENOG4105EY8 ABC transporter BS1321_13390 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) BS1321_13395 ENOG4105CJR Integral membrane protein (MviN BS1321_13415 ENOG4105ESV Glycosyl transferase, family 4 BS1321_13420 ENOG4108KGH TRANSCRIPTIONal BS1321_13425 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BS1321_13430 ENOG4105BZU Histidine kinase BS1321_13435 ENOG4105WH1 Two component transcriptional regulator luxr family BS1321_13475 ENOG4105E1Q flagellar hook-associated protein BS1321_13480 ENOG4105DTJ flagellar hook-associated protein BS1321_13490 ENOG4105D7V transposase BS1321_13495 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BS1321_13500 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BS1321_13505 ENOG4105I03 Flagellin BS1321_13515 ENOG41083S7 flagellar protein FlaG BS1321_13520 ENOG4107RT6 flagellar hook-associated BS1321_13525 ENOG4105MQ3 flagellar protein FliS BS1321_13535 ENOG4105MS2 ribosomal subunit Interface protein BS1321_13540 ENOG4108IMY Transcriptional regulator BS1321_13545 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BS1321_13550 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BS1321_13565 ENOG4105CAK Cell division ATP-binding protein ftsE BS1321_13570 ENOG4105CRP Part of the ABC transporter FtsEX involved in BS1321_13580 ENOG4105CN1 protease BS1321_13590 ENOG4108MES Periplasmic binding protein BS1321_13595 ENOG4108MES Periplasmic binding protein BS1321_13600 ENOG4105DQ5 transport system permease protein BS1321_13605 ENOG4108IHU transport system permease protein BS1321_13610 ENOG4108YYC ycei family BS1321_13615 ENOG4105EYF MMPL domain protein BS1321_13620 ENOG4105CH6 catalase BS1321_13630 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BS1321_13635 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BS1321_13640 ENOG4108PY7 BS1321_13650 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BS1321_13660 ENOG4105HKU nucleoside recognition domain-containing protein BS1321_13665 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BS1321_13670 ENOG4108S4C acetyltransferase BS1321_13685 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BS1321_13690 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BS1321_13695 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BS1321_13700 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BS1321_13705 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BS1321_13710 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BS1321_13715 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BS1321_13720 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BS1321_13730 ENOG4105C3M thioredoxin reductase BS1321_13735 ENOG4108Z4K mutator MutT protein BS1321_13740 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BS1321_13745 ENOG4105CHW UPF0052 protein BS1321_13755 ENOG4105KRI phosphocarrier protein (HPr BS1321_13760 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BS1321_13770 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_13785 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BS1321_13790 ENOG4105BZA Phosphoglycerate kinase BS1321_13795 ENOG4105CP7 Triose-phosphate isomerase BS1321_13800 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BS1321_13815 ENOG4108VXD carboxy-peptidase BS1321_13825 ENOG4105XZU Preprotein translocase, subunit SecG BS1321_13835 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BS1321_13840 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BS1321_13860 ENOG4108JB9 formate dehydrogenase BS1321_13865 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BS1321_13870 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BS1321_13875 ENOG4108KAM Transcriptional regulator BS1321_13885 ENOG4105JN3 extra-cytoplasmic solute receptor family protein BS1321_13900 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BS1321_13905 ENOG4108MRH transcriptional regulatory protein BS1321_13910 ENOG4105ECK Fatty Acid Desaturase BS1321_13915 ENOG4108ZGX Histidine kinase BS1321_13920 ENOG4108S01 response regulator BS1321_13925 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BS1321_13930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_13935 ENOG41062D9 Histidine kinase BS1321_13950 ENOG4105EWU Squalene--hopene cyclase BS1321_13960 ENOG4105ZKE UPF0349 protein BS1321_13965 ENOG4105DHS permease protein BS1321_13970 ENOG4105CM4 permease protein BS1321_13975 ENOG4108IPW abc transporter atp-binding protein BS1321_13990 ENOG4105E0M Sulfatase BS1321_13995 ENOG4105JSC dimethylmenaquinone methyltransferase BS1321_14025 ENOG4108B31 Spore germination protein BS1321_14035 ENOG4105CG3 alpha amylase, catalytic region BS1321_14040 ENOG4108IQI permease BS1321_14050 ENOG4105DSE periplasmic solute binding protein BS1321_14055 ENOG4105DIK (ABC) transporter BS1321_14060 ENOG4105CC5 ABC transporter BS1321_14065 ENOG4105CC5 ABC transporter BS1321_14095 ENOG4105CHU acetyl-coa acetyltransferase BS1321_14100 ENOG4105C1G acyl-Coa dehydrogenase BS1321_14105 ENOG41080E8 Transcriptional regulator, Spx MgsR family BS1321_14110 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BS1321_14130 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BS1321_14135 ENOG4108UMI ABC transporter, permease BS1321_14140 ENOG4105D01 (LipO)protein BS1321_14145 ENOG4105C3K feS assembly ATPase SufC BS1321_14150 ENOG4105JRK feS assembly protein SufD BS1321_14160 ENOG4108UNV SUF system FeS assembly protein, NifU family BS1321_14165 ENOG4105DIW FeS assembly protein SUFB BS1321_14170 ENOG4105I3N Conserved Protein BS1321_14180 ENOG4107R8B 5'-nucleotidase BS1321_14185 ENOG4105KZD Domain of unknown function (DUF1805) BS1321_14190 ENOG4105CPI Metal Dependent Phosphohydrolase BS1321_14195 ENOG4108YTE sporulation protein YunB BS1321_14200 ENOG4105FAA peptidase M23 BS1321_14205 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BS1321_14210 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) BS1321_14215 ENOG4105MMD transcriptional regulator BS1321_14235 ENOG4105D4U had-superfamily hydrolase, subfamily iia BS1321_14240 ENOG4108W5N phosphatidylglycerophosphatase a BS1321_14255 ENOG4105D6E homoserine dehydrogenase BS1321_14260 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BS1321_14265 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BS1321_14270 ENOG41083MR nifu domain-containing protein BS1321_14285 ENOG4105ZKE UPF0349 protein BS1321_14295 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BS1321_14305 ENOG4105CAY ferredoxin--nadp reductase BS1321_14310 ENOG4105CEP NADH dehydrogenase BS1321_14325 ENOG41069ER domain protein BS1321_14340 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BS1321_14350 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BS1321_14355 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BS1321_14365 ENOG4108UX3 '-nucleotidase BS1321_14370 ENOG4105KA0 thioesterase Superfamily protein BS1321_14380 ENOG4105KJM monovalent cation h antiporter subunit g BS1321_14390 ENOG4105SC1 monovalent cation H antiporter subunit E BS1321_14395 ENOG4108JPZ Monovalent cation H antiporter subunit D BS1321_14400 ENOG4108ZE9 Monovalent cation H antiporter subunit C BS1321_14405 ENOG4105HC0 Na H antiporter BS1321_14410 ENOG4105D65 subunit l BS1321_14420 ENOG4105BZ4 penicillin-binding protein BS1321_14430 ENOG4105Y38 Kinase-associated protein B BS1321_14435 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BS1321_14445 ENOG4108YM7 Gcn5-related n-acetyltransferase BS1321_14450 ENOG4108QCI YvbH-like oligomerisation region BS1321_14465 ENOG4105C87 Aminotransferase class I and II BS1321_14475 ENOG4108MUZ hydrolase BS1321_14480 ENOG4108ZB6 transcriptional regulator AsnC family BS1321_14485 ENOG4105CHM Aminotransferase BS1321_14495 ENOG4105C8J )-transporter BS1321_14505 ENOG4105WG9 Conserved Protein BS1321_14510 ENOG4107QW4 alcohol dehydrogenase BS1321_14530 ENOG4107PBV potassium channel BS1321_14535 ENOG4105VRS hydrolase family 18 BS1321_14545 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS1321_14550 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BS1321_14555 ENOG4107R7I amino acid BS1321_14560 ENOG4105D94 Major Facilitator Superfamily BS1321_14590 ENOG4106DF4 Sigma-70, region 4 BS1321_14605 ENOG4105CGH 5'-nucleotidase BS1321_14620 ENOG4105C85 amino acid BS1321_14625 ENOG4108K8S endonuclease I BS1321_14630 ENOG41086DT Membrane protein of unknown function BS1321_14665 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BS1321_14670 ENOG4105G6Z alkaline phosphatase BS1321_14680 ENOG4105PKS Excinuclease abc c subunit domain protein BS1321_14685 ENOG4105CKI cobalamin synthesis protein BS1321_14690 ENOG4105WDJ 50S ribosomal protein L33 BS1321_14695 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BS1321_14705 ENOG41085AS UPF0473 protein BS1321_14715 ENOG4105BZU Histidine kinase BS1321_14725 ENOG4107ZE5 PPIases accelerate the folding of proteins BS1321_14765 ENOG4108IQI permease BS1321_14780 ENOG4108RWP Major Facilitator Superfamily protein BS1321_14785 ENOG4105WAB arsR family transcriptional regulator BS1321_14800 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BS1321_14815 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BS1321_14820 ENOG4107YHD transcriptional regulator BS1321_14825 ENOG4105CK7 Sodium proline symporter BS1321_14830 ENOG4105C26 Dehydrogenase BS1321_14845 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_14865 ENOG4105KT7 mgtC SapB transporter BS1321_15005 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BS1321_15010 ENOG4105E4F Isochorismate synthase BS1321_15015 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BS1321_15020 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BS1321_15025 ENOG4108IPT Naphthoate synthase BS1321_15030 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_15035 ENOG4105DTQ mandelate racemase muconate lactonizing BS1321_15045 ENOG4108MRH transcriptional regulatory protein BS1321_15050 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BS1321_15055 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BS1321_15060 ENOG4105DSE periplasmic solute binding protein BS1321_15065 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BS1321_15070 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BS1321_15075 ENOG4108RMU ferritin dps family protein BS1321_15090 ENOG41062IR nudix hydrolase BS1321_15095 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BS1321_15105 ENOG4105D2X ABC transporter substrate-binding protein BS1321_15120 ENOG4105EWC Purine nucleoside phosphorylase BS1321_15140 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BS1321_15165 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BS1321_15170 ENOG4108Z0R Transferase BS1321_15175 ENOG4105E8V Alpha Beta Hydrolase Fold protein BS1321_15190 ENOG4105N5T Radical SAM Protein BS1321_15205 ENOG4105C8T Leucyl-tRNA synthetase BS1321_15210 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BS1321_15220 ENOG4106NWU BS1321_15235 ENOG4108RDQ ABC transporter BS1321_15255 ENOG4105C5Q Transcriptional regulator BS1321_15260 ENOG4105CBC glutamate synthase BS1321_15265 ENOG4105BZ8 glutamate synthase BS1321_15270 ENOG4108PGP mmge prpd family protein BS1321_15280 ENOG4108HW4 amino acid AbC transporter BS1321_15285 ENOG4105EAB amino acid AbC transporter BS1321_15290 ENOG4108XSB acetyltransferase, (GNAT) family BS1321_15295 ENOG4105CPU Monooxygenase BS1321_15300 ENOG4105CH2 amidohydrolase BS1321_15315 ENOG4105X5K response regulator receiver protein BS1321_15325 ENOG4108UW5 maltose o-acetyltransferase BS1321_15335 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BS1321_15340 ENOG4107T89 von Willebrand factor, type A BS1321_15355 ENOG4107EXU Short-chain dehydrogenase reductase Sdr BS1321_15375 ENOG4105ENY Ethanolamine utilization protein eutH BS1321_15380 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase BS1321_15385 ENOG4105CPD ethanolamine ammonia-lyase BS1321_15405 ENOG4108ZJ4 polysaccharide deacetylase BS1321_15410 ENOG4105JVQ RNA Polymerase BS1321_15415 ENOG4108P49 AntiSigma factor BS1321_15425 ENOG4105DUX Transporter BS1321_15455 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS1321_15460 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BS1321_15480 ENOG4107ZTW SNARE associated Golgi BS1321_15490 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BS1321_15495 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BS1321_15510 ENOG4105RHY Pfam:UPF0157 BS1321_15520 ENOG4105CHR reductase BS1321_15530 ENOG4105D7K pfkb domain protein BS1321_15535 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BS1321_15540 ENOG4105RHY Pfam:UPF0157 BS1321_15560 ENOG4105CZV ABC transporter BS1321_15575 ENOG4105CZM Major Facilitator BS1321_15620 ENOG4105SZ6 Thioredoxin BS1321_15625 ENOG41062ES Transcriptional regulator BS1321_15630 ENOG4105ECB domain protein BS1321_15635 ENOG41082BM Transcriptional regulator, arsr family BS1321_15660 ENOG4108Z40 Transcriptional regulator BS1321_15665 ENOG4107ZQN disulfide bond BS1321_15675 ENOG4108RYK Nad-dependent epimerase dehydratase BS1321_15685 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS1321_15690 ENOG4107SJB teichoic acid biosynthesis BS1321_15695 ENOG4105CMR udp-glucose 4-epimerase BS1321_15705 ENOG4105JAB phenazine biosynthesis protein, phzf family BS1321_15720 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BS1321_15725 ENOG41088CC tellurite resistance protein tehB BS1321_15730 ENOG4106SCS STAS domain BS1321_15735 ENOG4107ZYR domain protein BS1321_15740 ENOG4105CZN Potassium uptake protein BS1321_15775 ENOG4105CIN aminoacyl-histidine dipeptidase BS1321_15780 ENOG4108S3Y transcriptional regulator BS1321_15785 ENOG4105VRS hydrolase family 18 BS1321_15790 ENOG4107TIF Phenazine biosynthesis protein, PhzF family BS1321_15800 ENOG4105CIG ABC transporter BS1321_15805 ENOG4105DIM ABC transporter BS1321_15820 ENOG4108JCI Transcriptional regulator BS1321_15825 ENOG4105CGH 5'-nucleotidase BS1321_15830 ENOG4108K8S endonuclease I BS1321_15840 ENOG4105EJQ L-serine dehydratase BS1321_15865 ENOG4105ENX hydrolase BS1321_15870 ENOG4105ST3 Transcriptional regulator BS1321_15880 ENOG4105CUB amino acid BS1321_15925 ENOG4108B31 Spore germination protein BS1321_15930 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BS1321_15945 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BS1321_15990 ENOG4105VUF Transcriptional regulator BS1321_15995 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS1321_16005 ENOG4108KS4 Spore coat protein BS1321_16010 ENOG4107SBE Glycosyl transferase (Group 1 BS1321_16015 ENOG4108IAJ Nad-dependent epimerase dehydratase BS1321_16030 ENOG41073R8 VanW family BS1321_16035 ENOG4108DMH HTH_ARAC BS1321_16040 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BS1321_16045 ENOG4105NPE arsR family transcriptional regulator BS1321_16050 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase BS1321_16105 ENOG4108U05 Transcriptional regulator BS1321_16110 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BS1321_16115 ENOG4105JAB phenazine biosynthesis protein, phzf family BS1321_16120 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_16125 ENOG4108VP3 Lysine exporter protein (LysE YggA) BS1321_16145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_16160 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BS1321_16195 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BS1321_16250 ENOG4105CNI cell division protein FtsW BS1321_16280 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BS1321_16345 ENOG4105ERH Fumarylacetoacetate hydrolase BS1321_16355 ENOG4105KVH Transcriptional regulator BS1321_16385 ENOG4108XET gCN5-related N-acetyltransferase BS1321_16390 ENOG4105DFD Na H antiporter BS1321_16395 ENOG4105DCF alanine dehydrogenase BS1321_16400 ENOG4108JUB Transcriptional regulator BS1321_16430 ENOG4105EA8 2-Nitropropane dioxygenase BS1321_16435 ENOG4105CBP Major Facilitator BS1321_16440 ENOG41090U3 tautomerase BS1321_16460 ENOG41090MY MarR family Transcriptional regulator BS1321_16465 ENOG41087PP glycosyltransferase MGT family BS1321_16500 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BS1321_16505 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BS1321_16530 ENOG4105CRN Aminoglycoside phosphotransferase BS1321_16535 ENOG4105WCN acetyltransferase BS1321_16540 ENOG41069ER domain protein BS1321_16545 ENOG4107YBY Hydrolase BS1321_16560 ENOG4105CJ1 ABC, transporter BS1321_16565 ENOG4108TU7 Inherit from COG: (ABC) transporter BS1321_16595 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) BS1321_16600 ENOG4105GZI Transcriptional regulator BS1321_16605 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS1321_16615 ENOG4105K4H Nlp p60 protein BS1321_16625 ENOG4105ECK Fatty Acid Desaturase BS1321_16630 ENOG4108S01 response regulator BS1321_16635 ENOG4105C75 arginyL-tRNA synthetase BS1321_16640 ENOG4108M60 Transcriptional regulator BS1321_16650 ENOG4105D7K pfkb domain protein BS1321_16660 ENOG4108VA3 3-hexulose-6-phosphate synthase BS1321_16665 ENOG41080HJ 6-phospho 3-hexuloisomerase BS1321_16680 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BS1321_16695 ENOG41068WN BS1321_16725 ENOG4105CNG UPF0061 protein BS1321_16735 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS1321_16745 ENOG41075H3 AraC family transcriptional regulator BS1321_16750 ENOG4105C2F Histidine kinase BS1321_16755 ENOG4108JQ7 (ABC) transporter BS1321_16760 ENOG4105C3U ABC transporter BS1321_16770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS1321_16775 ENOG4105DEF Extracellular solute-binding protein, family 5 BS1321_16780 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BS1321_16790 ENOG4105DEF Extracellular solute-binding protein, family 5 BS1321_16795 ENOG4105DZC cytosine deaminase BS1321_16800 ENOG4105DZC cytosine deaminase BS1321_16805 ENOG4105DZC cytosine deaminase BS1321_16810 ENOG4105DTE Xanthine uracil vitamin C permease BS1321_16815 ENOG41086KC Transcriptional regulator BS1321_16820 ENOG4105C26 Dehydrogenase BS1321_16825 ENOG4105F11 amine oxidase BS1321_16855 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_16875 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BS1321_16895 ENOG4105DU0 nucleoside hydrolase BS1321_16900 ENOG4105F38 ABC transporter, permease BS1321_16905 ENOG4105F38 ABC transporter, permease BS1321_16910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS1321_16915 ENOG4105CPN adenine deaminase BS1321_16920 ENOG4105C98 muts2 protein BS1321_16930 ENOG4105EGI Transcriptional regulator BS1321_16935 ENOG4108KAM Transcriptional regulator BS1321_16950 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BS1321_16965 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BS1321_16975 ENOG41083I7 UPF0145 protein BS1321_16980 ENOG4108KQI regulatory protein luxr BS1321_16995 ENOG4108HRK Histidine kinase BS1321_17000 ENOG4105DY9 regulatoR BS1321_17015 ENOG4108VQJ O-methyltransferase BS1321_17025 ENOG4105J7D transcriptional regulator BS1321_17030 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_17050 ENOG4105CHJ isochorismatase hydrolase BS1321_17055 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BS1321_17075 ENOG4105J7I hydrolase BS1321_17080 ENOG4105ETE Transcriptional regulator (LacI family BS1321_17085 ENOG4105CHR reductase BS1321_17090 ENOG4105C0A alcohol dehydrogenase BS1321_17105 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) BS1321_17110 ENOG4105CNV Aldolase BS1321_17120 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BS1321_17135 ENOG4108HUF Transporter BS1321_17140 ENOG4105DQ5 transport system permease protein BS1321_17145 ENOG4108U1V ABC transporter, permease BS1321_17150 ENOG4105E0A ABC, transporter BS1321_17155 ENOG4105F0F Oxalate decarboxylase BS1321_17165 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BS1321_17170 ENOG4105D7V transposase BS1321_17185 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BS1321_17190 ENOG4108UMI ABC transporter, permease BS1321_17245 ENOG4108URH decarboxylase BS1321_17250 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BS1321_17255 ENOG41067SE Tetr family transcriptional regulator BS1321_17260 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BS1321_17300 ENOG4107U9B transcriptional regulator BS1321_17305 ENOG4108UMN azlc family BS1321_17310 ENOG4105KMT branched-chain amino acid BS1321_17325 ENOG4105BZC d-serine deaminase BS1321_17340 ENOG4107WCI zn-dependent hydrolase of the beta-lactamase fold-like protein BS1321_17405 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BS1321_17415 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_17420 ENOG41062D9 Histidine kinase BS1321_17430 ENOG4108V2W Carbonate dehydratase BS1321_17435 ENOG4105CHH sulfate transporter BS1321_17440 ENOG4108HWY Beta-lactamase BS1321_17480 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BS1321_17485 ENOG4108JQ1 Dehydrogenase BS1321_17510 ENOG4105X3H Excalibur domain protein BS1321_17520 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BS1321_17530 ENOG4108IJ0 Aspartate ammonia-lyase BS1321_17555 ENOG4105EEM helicase BS1321_17565 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BS1321_17570 ENOG4108HGU Histidine kinase BS1321_17590 ENOG4105CIF Ornithine Cyclodeaminase BS1321_17595 ENOG4105CSH Transporter BS1321_17610 ENOG4108SA1 esterase BS1321_17620 ENOG4108UMI ABC transporter, permease BS1321_17625 ENOG4105D01 (LipO)protein BS1321_17630 ENOG4106BHF BS1321_17660 ENOG4106ANW SMI1_KNR4 BS1321_17720 ENOG4105CFI type iii restriction protein res subunit BS1321_17745 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BS1321_17770 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BS1321_17785 ENOG4105NAE bifunctional deaminase-reductase domain protein BS1321_17810 ENOG4105GZI Transcriptional regulator BS1321_17850 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BS1321_17855 ENOG4108TGC Acyltransferase BS1321_17860 ENOG4105DZ1 carboxypeptidase BS1321_17885 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid BS1321_17905 ENOG41069DP small acid-soluble spore protein BS1321_17915 ENOG41086D8 Transcriptional regulator BS1321_17955 ENOG4105DTD Dehydrogenase BS1321_17960 ENOG4105F35 Catalyzes the NAD( )-dependent oxidation of L-carnitine to 3-dehydrocarnitine (By similarity) BS1321_17965 ENOG4105CHU acetyl-coa acetyltransferase BS1321_17970 ENOG4108JUB Transcriptional regulator BS1321_17980 ENOG4105CY2 Citrate transporter BS1321_17985 ENOG4105D6N CoA-transferase, subunit a BS1321_17990 ENOG4108IIH CoA-transferase subunit B BS1321_18005 ENOG4108JUB Transcriptional regulator BS1321_18010 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BS1321_18030 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS1321_18045 ENOG4105CHU acetyl-coa acetyltransferase BS1321_18050 ENOG4107S4Y M20 DapE family protein YgeY BS1321_18070 ENOG4105C22 threonyL-tRNA synthetase BS1321_18090 ENOG4105CN5 Metallo-Beta-Lactamase BS1321_18095 ENOG41067SE Tetr family transcriptional regulator BS1321_18100 ENOG4105C0R drug resistance transporter emrb qaca subfamily BS1321_18105 ENOG4105ECB domain protein BS1321_18110 ENOG4107RSM transcriptional regulator BS1321_18125 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BS1321_18130 ENOG41073TP transcriptional regulator BS1321_18140 ENOG4105DJB Major Facilitator Superfamily BS1321_18145 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase BS1321_18150 ENOG4105C26 Dehydrogenase BS1321_18160 ENOG4105DJB Major Facilitator Superfamily BS1321_18165 ENOG4105CTX dehydratase BS1321_18195 ENOG4107S1Q Phosphatase BS1321_18210 ENOG4107ZXU DSBA oxidoreductase BS1321_18215 ENOG4108TVJ Nitroreductase BS1321_18230 ENOG4108R5S membrane BS1321_18235 ENOG4105F2Z 3-oxoadipate enol-lactonase BS1321_18250 ENOG4107RZC phospholipase d BS1321_18255 ENOG4107YH7 Beta-lactamase (EC 3.5.2.6) BS1321_18265 ENOG4105N14 lysine exporter protein LysE YggA BS1321_18270 ENOG4106IPI cyclase, family BS1321_18275 ENOG4105HJ8 Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity) BS1321_18280 ENOG4105C85 amino acid BS1321_18285 ENOG4105CKY Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity) BS1321_18310 ENOG4105ENE Histidine kinase BS1321_18315 ENOG4105WH1 Two component transcriptional regulator luxr family BS1321_18360 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BS1321_18365 ENOG4108MRH transcriptional regulatory protein BS1321_18370 ENOG4105D4T Citrate transporter BS1321_18375 ENOG4108ZDA Sporulation protein YyaC BS1321_18380 ENOG4105DDN Pentapeptide repeat-containing protein BS1321_18385 ENOG4107TXC Transcriptional regulator BS1321_18390 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BS1321_18400 ENOG4106N3A copper homeostasis protein cutc BS1321_18410 ENOG41081VB Hydrolase BS1321_18415 ENOG4107CUJ Protein of unknown function (DUF2690) BS1321_18420 ENOG4107CUJ Protein of unknown function (DUF2690) BS1321_18425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BS1321_18435 ENOG4105D03 DNA-3-methyladenine glycosylase II BS1321_18450 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BS1321_18455 ENOG4108MRH transcriptional regulatory protein BS1321_18460 ENOG4105D4T Citrate transporter BS1321_18465 ENOG4105CTS PTS system mannitol-specific BS1321_18470 ENOG4105ETD TRANSCRIPTIONal BS1321_18475 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BS1321_18485 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS1321_18495 ENOG4105C3U ABC transporter BS1321_18500 ENOG4108JQ7 (ABC) transporter BS1321_18505 ENOG4107R73 Mate efflux family protein BS1321_18510 ENOG410642S Nicotianamine synthase protein BS1321_18520 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BS1321_18530 ENOG4108JUB Transcriptional regulator BS1321_18535 ENOG4105C26 Dehydrogenase BS1321_18540 ENOG4105C8Y Acetylornithine aminotransferase BS1321_18570 ENOG410841Q phosphoesterase PA-phosphatase related protein BS1321_18575 ENOG4107T5V SNARE associated Golgi BS1321_18580 ENOG4105E1K spore germination protein BS1321_18610 ENOG4105VMP Transcriptional regulator BS1321_18615 ENOG4105NX3 Membrane BS1321_18620 ENOG41080TC multidrug resistance protein BS1321_18635 ENOG4105KRN Transcriptional regulator, abrb family BS1321_18640 ENOG4105KD7 acetyltransferase BS1321_18660 ENOG4108YYS metal-dependent hydrolase (By similarity) BS1321_18695 ENOG4105K7W phage-related replication protein BS1321_18725 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BS1321_18735 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BS1321_18745 ENOG4108IG5 Transcriptional regulator BS1321_18755 ENOG4107TVP HD domain protein BS1321_18805 ENOG4105KVH Transcriptional regulator BS1321_18810 ENOG4105F27 Major Facilitator BS1321_18815 ENOG4105CV8 reductase BS1321_18820 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BS1321_18825 ENOG41085GJ domain protein BS1321_18830 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS1321_18840 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BS1321_18855 ENOG4105CBX hi0933 family BS1321_18870 ENOG4105YW5 deoR family transcriptional regulator BS1321_18880 ENOG4105MVE transcriptional regulator BS1321_18890 ENOG4107RCV ABC transporter, permease BS1321_18900 ENOG4107STF Involved in phosphonate degradation (By similarity) BS1321_18905 ENOG4108KAZ Involved in phosphonate degradation (By similarity) BS1321_18910 ENOG4105CUB amino acid BS1321_18915 ENOG4105DCF alanine dehydrogenase BS1321_18920 ENOG4105G9B Transcriptional regulator BS1321_18925 ENOG4105CAY ferredoxin--nadp reductase BS1321_18930 ENOG4108HVR ABC transporter, permease BS1321_18935 ENOG4105C19 ABC transporter BS1321_18940 ENOG4105EWM Histidine kinase BS1321_18945 ENOG4105CJZ response regulator BS1321_18950 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BS1321_18960 ENOG4105DB7 PHP domain protein BS1321_18985 ENOG4105FT8 Phosphonate metabolism BS1321_18990 ENOG4105ENV phosphonate C-P lyase system protein PhnK BS1321_18995 ENOG4105FD8 phosphonate metabolism protein PhnM BS1321_19000 ENOG4105HRV phosphonate c-p lyase system protein phnl BS1321_19010 ENOG4105D5T phosphonate abc transporter BS1321_19020 ENOG4105S7S phosphonate abc transporter BS1321_19035 ENOG4108PJD permease BS1321_19045 ENOG4105C26 Dehydrogenase BS1321_19055 ENOG4108RNG Permease of the drug metabolite transporter BS1321_19065 ENOG4107ZXU DSBA oxidoreductase BS1321_19075 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BS1321_19080 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS1321_19110 ENOG4107ZTW SNARE associated Golgi BS1321_19120 ENOG4107R73 Mate efflux family protein BS1321_19125 ENOG4107QSE Dipeptidase BS1321_19140 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BS1321_19160 ENOG4108V15 phosphotransferase enzyme family BS1321_19170 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BS1321_19175 ENOG4105C8F Beta-lactamase domain protein BS1321_19190 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BS1321_19195 ENOG41086D8 Transcriptional regulator BS1321_19200 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BS1321_19215 ENOG4108NKM UPF0354 protein BS1321_19230 ENOG4105DFU Cell wall formation (By similarity) BS1321_19235 ENOG4105C88 aminopeptidase BS1321_19255 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BS1321_19260 ENOG4105ETE Transcriptional regulator (LacI family BS1321_19265 ENOG4105DGU Histone deacetylase BS1321_19270 ENOG4105W87 Cbs domain BS1321_19275 ENOG4105F1V Acetoin utilization protein BS1321_19290 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BS1321_19295 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BS1321_19305 ENOG41082JN Transcriptional regulator BS1321_19310 ENOG4108W76 histidinol phosphate phosphatase hisj family BS1321_19315 ENOG4105DGY modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity) BS1321_19325 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BS1321_19335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BS1321_19340 ENOG4105EFZ amidohydrolase BS1321_19345 ENOG4105FR1 rard protein BS1321_19355 ENOG4105D2X ABC transporter substrate-binding protein BS1321_19365 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BS1321_19375 ENOG4108RE7 deoxyribonuclease BS1321_19380 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BS1321_19390 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BS1321_19395 ENOG4107S2N Type III effector Hrp-dependent BS1321_19400 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BS1321_19405 ENOG4105D07 Signal peptide peptidase, SppA BS1321_19410 ENOG4105VK3 rdd domain containing protein BS1321_19420 ENOG4105KBJ sporulation protein ytfj BS1321_19425 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BS1321_19440 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BS1321_19450 ENOG4105EPU Molybdenum cofactor synthesis domain protein BS1321_19460 ENOG4105CDH Citrulline--aspartate ligase BS1321_19465 ENOG4105CH7 arginosuccinase BS1321_19470 ENOG4107YZX Universal stress protein BS1321_19475 ENOG4105DC7 peptidase M24 BS1321_19480 ENOG4105E8R UPF0173 metal-dependent hydrolase BS1321_19500 ENOG4105SFS phosphoesterase RecJ domain protein BS1321_19510 ENOG4105VV2 BS1321_19515 ENOG4105C0B DNA polymerase III (alpha subunit) BS1321_19520 ENOG4105C6K Malic enzyme BS1321_19525 ENOG4107YCY Transcriptional regulator BS1321_19530 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BS1321_19535 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BS1321_19540 ENOG4105CTQ phosphohexokinase BS1321_19545 ENOG4105CA9 Pyruvate kinase BS1321_19555 ENOG4107QP3 malate synthase g BS1321_19565 ENOG4108REF Sporulation integral membrane protein ytvi BS1321_19570 ENOG4107CWS Protein of unknown function (DUF441) BS1321_19575 ENOG4105BZN citrate synthase BS1321_19580 ENOG4108HMX isocitrate dehydrogenase (NADP) BS1321_19590 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS1321_19595 ENOG4105BZU Histidine kinase BS1321_19605 ENOG4105EPW hflc protein BS1321_19610 ENOG4105C2M dna polymerase I BS1321_19615 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BS1321_19625 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BS1321_19630 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BS1321_19635 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BS1321_19640 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) BS1321_19655 ENOG4108TDW sporulation protein YtxC BS1321_19660 ENOG4105C22 threonyL-tRNA synthetase BS1321_19670 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BS1321_19680 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BS1321_19685 ENOG410696E Membrane BS1321_19705 ENOG4105CN9 Peptidase m42 family protein BS1321_19715 ENOG4107QR9 Iron-sulfur cluster binding protein BS1321_19720 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BS1321_19725 ENOG4105JXH GntR family transcriptional regulator BS1321_19730 ENOG4105DAA L-lactate BS1321_19740 ENOG4105CQB FAD linked oxidase domain protein BS1321_19745 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BS1321_19750 ENOG4107KM7 Heat induced stress protein YflT BS1321_19770 ENOG41067MF small acid-soluble spore protein BS1321_19775 ENOG4108RWN rrna methyltransferase BS1321_19780 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BS1321_19785 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BS1321_19790 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BS1321_19795 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BS1321_19805 ENOG4105DCG PHP domain protein BS1321_19810 ENOG4105C98 muts2 protein BS1321_19825 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_19830 ENOG4107Z3H Transcriptional regulator, TetR family BS1321_19835 ENOG41060WC Enoyl-CoA hydratase BS1321_19840 ENOG4105BZJ Electron transfer flavoprotein BS1321_19845 ENOG4105C10 Electron transfer flavoprotein BS1321_19850 ENOG4105K63 Thioredoxin BS1321_19870 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BS1321_19880 ENOG4105E33 succinate dehydrogenase BS1321_19890 ENOG4105PFC Transcriptional regulator BS1321_19895 ENOG41067TZ transcriptional regulator, MarR family BS1321_19910 ENOG4108XJQ germination protein BS1321_19930 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BS1321_19935 ENOG4105M59 Phosphodiesterase, mj0936 family BS1321_20025 ENOG4105C7K acetolactate synthase BS1321_20030 ENOG4108ZP8 Acetolactate synthase small subunit BS1321_20035 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BS1321_20040 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BS1321_20045 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BS1321_20050 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BS1321_20055 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BS1321_20065 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BS1321_20070 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BS1321_20075 ENOG4108IUQ atp-dependent protease BS1321_20080 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BS1321_20085 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BS1321_20095 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BS1321_20105 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BS1321_20115 ENOG4105D52 delta-aminolevulinic acid dehydratase BS1321_20120 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BS1321_20125 ENOG41068KH stage VI sporulation protein D BS1321_20130 ENOG4106AR7 Spore coat protein BS1321_20145 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BS1321_20155 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BS1321_20160 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BS1321_20165 ENOG4106A3R peptidase BS1321_20180 ENOG4105W5Q DNA repair protein (RadC BS1321_20185 ENOG4105DFF Rod shape-determining protein mreb BS1321_20190 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BS1321_20200 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BS1321_20205 ENOG4107QMS site-determining protein BS1321_20210 ENOG41060GV RNA binding s1 domain protein BS1321_20225 ENOG4105C03 ribonuclease BS1321_20230 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BS1321_20235 ENOG4105X36 (ribosomal) protein BS1321_20240 ENOG4105K46 50S ribosomal protein l27 BS1321_20250 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BS1321_20255 ENOG41090I5 UPF0735 ACT domain-containing protein BS1321_20260 ENOG4105CQC Prephenate dehydratase BS1321_20280 ENOG4108IYU L-aspartate oxidase BS1321_20285 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BS1321_20295 ENOG4105CGZ zinc metallopeptidase BS1321_20320 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BS1321_20330 ENOG41061AI Protein of unknown function (DUF2905) BS1321_20335 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BS1321_20340 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BS1321_20345 ENOG4105VIE preprotein translocase, subunit YajC BS1321_20350 ENOG4105NAP BS1321_20355 ENOG4108QG2 Membrane BS1321_20360 ENOG4105CKP Polysaccharide Biosynthesis Protein BS1321_20370 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BS1321_20375 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BS1321_20380 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BS1321_20385 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BS1321_20390 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BS1321_20395 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BS1321_20400 ENOG4105CUT histidyl-tRNA synthetase BS1321_20405 ENOG4105C9M aspartyl-trna synthetase BS1321_20435 ENOG4105CUZ uba thif-type nad fad binding protein BS1321_20440 ENOG4105CP9 extracellular ligand-binding receptor BS1321_20445 ENOG4105C32 Amino acid ABC transporter (Permease) BS1321_20450 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BS1321_20455 ENOG4105C0Z ABC transporter BS1321_20460 ENOG4108IV0 ABC, transporter BS1321_20465 ENOG4105CP9 extracellular ligand-binding receptor BS1321_20470 ENOG4105C32 Amino acid ABC transporter (Permease) BS1321_20475 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BS1321_20480 ENOG4105C0Z ABC transporter BS1321_20485 ENOG4108IV0 ABC, transporter BS1321_20510 ENOG4105CZM Major Facilitator BS1321_20525 ENOG4105HTX biosynthesis protein BS1321_20530 ENOG4107YJ4 chain length determinant protein BS1321_20535 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BS1321_20545 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS1321_20550 ENOG4105D3Q Sugar transferase BS1321_20560 ENOG4108PQP glycosyl transferase group 1 BS1321_20570 ENOG4105K64 Glycosyl transferase, family 2 BS1321_20580 ENOG4105D7W serine acetyltransferase BS1321_20640 ENOG4105BZ1 (ABC) transporter BS1321_20655 ENOG4105BZ1 (ABC) transporter BS1321_20665 ENOG4108KGH TRANSCRIPTIONal BS1321_20670 ENOG4105CZV ABC transporter BS1321_20685 ENOG4105D1H recombination factor protein RarA BS1321_20695 ENOG4105C3J Cysteine desulfurase BS1321_20700 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BS1321_20710 ENOG4105C7H Helicase, RecD TraA family BS1321_20715 ENOG4108V0P LemA family BS1321_20730 ENOG41060CR BS1321_20735 ENOG4105C02 permease BS1321_20745 ENOG4105VBH UPF0297 protein BS1321_20750 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BS1321_20755 ENOG4105VPH UPF0473 protein BS1321_20760 ENOG4105HHA aminodeoxychorismate lyase BS1321_20765 ENOG4108VQJ O-methyltransferase BS1321_20770 ENOG4105XYU peptidase (U32 family) BS1321_20775 ENOG4105CFP Peptidase U32 BS1321_20785 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BS1321_20790 ENOG4107XRG penicillin-binding protein BS1321_20805 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) BS1321_20810 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) BS1321_20820 ENOG4105C28 cystathionine BS1321_20835 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_20850 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BS1321_20855 ENOG4105DJ4 phosphatidylserine decarboxylase BS1321_20860 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BS1321_20865 ENOG4105CQW ribosome biogenesis GTPase YqeH BS1321_20875 ENOG410812S Rna-binding protein BS1321_20880 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BS1321_20885 ENOG4108WF2 Metal Dependent Phosphohydrolase BS1321_20895 ENOG4105DXX methyltransferase BS1321_20905 ENOG4105KQC Competence protein BS1321_20910 ENOG4108UK2 deaminase BS1321_20915 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BS1321_20920 ENOG4105TQK DNA polymerase iii, delta' subunit BS1321_20935 ENOG4108ZRV stage ii sporulation protein p BS1321_20945 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BS1321_20950 ENOG4105CSA Coproporphyrinogen iii oxidase BS1321_20955 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BS1321_20960 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BS1321_20965 ENOG4105CFG Acts as a chaperone (By similarity) BS1321_20970 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BS1321_20975 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BS1321_20980 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BS1321_20985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BS1321_20990 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BS1321_21005 ENOG4105VCC 30S ribosomal protein S21 BS1321_21010 ENOG4105KTH gatB Yqey BS1321_21015 ENOG4105F7J membrane-bound serine protease BS1321_21020 ENOG4105DI5 UPF0365 protein BS1321_21030 ENOG41068P3 sporulation protein YqfC BS1321_21040 ENOG4105C9A Phoh family BS1321_21045 ENOG4105CTJ Metal Dependent Phosphohydrolase BS1321_21050 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BS1321_21055 ENOG4107YR5 Diacylglycerol kinase BS1321_21060 ENOG4105KG3 cytidine deaminase BS1321_21065 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BS1321_21075 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) BS1321_21080 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BS1321_21085 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BS1321_21095 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BS1321_21100 ENOG4107XJU UPF0178 protein BS1321_21105 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BS1321_21110 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_21130 ENOG4105EGD dinuclear metal center protein, YbgI family BS1321_21135 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BS1321_21150 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BS1321_21160 ENOG4105FDK ABC transporter BS1321_21165 ENOG4105FAV ABC, transporter BS1321_21170 ENOG4105N80 Ferric uptake regulator, Fur family BS1321_21175 ENOG4108U5J '-nucleotidase BS1321_21180 ENOG41063Y9 BS1321_21185 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BS1321_21205 ENOG4105SXS Protein of unknown function (DUF456) BS1321_21220 ENOG4107RF6 penicillin-binding protein BS1321_21225 ENOG4105EXS phosphate abc transporter BS1321_21230 ENOG4105C8U phosphate abc transporter BS1321_21235 ENOG4105E2Z phosphate ABC transporter (Permease BS1321_21240 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BS1321_21245 ENOG4108UTW Plays a role in the regulation of phosphate uptake BS1321_21270 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BS1321_21280 ENOG4107ZXI Rhomboid family BS1321_21295 ENOG4105DKQ ROK family BS1321_21300 ENOG4105E0M Sulfatase BS1321_21320 ENOG4105C5X domain protein BS1321_21355 ENOG4106855 Competence protein BS1321_21390 ENOG4105C0D helicase BS1321_21400 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BS1321_21405 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BS1321_21410 ENOG4105WZW rhodanese family BS1321_21415 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BS1321_21420 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BS1321_21445 ENOG4105CBJ Metal-dependent enzyme BS1321_21460 ENOG4105DC7 peptidase M24 BS1321_21465 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BS1321_21470 ENOG4105CD2 stage iii sporulation protein aa BS1321_21475 ENOG4105KR5 Stage iii sporulation protein BS1321_21480 ENOG4108CQH stage III sporulation protein AC BS1321_21485 ENOG4105KQ4 Stage iii sporulation protein ad BS1321_21495 ENOG410644B Stage III sporulation protein af BS1321_21515 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BS1321_21520 ENOG4108ZSR alkaline shock protein BS1321_21525 ENOG4105M7K Involved in the transcription termination process (By similarity) BS1321_21530 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BS1321_21535 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BS1321_21540 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BS1321_21550 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BS1321_21555 ENOG4105DX0 Hemolysin A BS1321_21560 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BS1321_21565 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BS1321_21570 ENOG4105S1Z Stage IV sporulation protein B BS1321_21575 ENOG4107QQR Sporulation BS1321_21585 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BS1321_21590 ENOG4106CCJ Protein of unknown function (DUF2627) BS1321_21595 ENOG4108JUB Transcriptional regulator BS1321_21600 ENOG4107RDP Dehydrogenase BS1321_21615 ENOG4105CPP Dehydrogenase, E1 component BS1321_21620 ENOG4105C7S Dehydrogenase BS1321_21625 ENOG4105CMN Methylmalonyl-coA mutase BS1321_21630 ENOG4105D5P Methylmalonyl-coA mutase BS1321_21640 ENOG4108Y6J UPF0403 protein BS1321_21645 ENOG4108HW3 (ABC) transporter BS1321_21650 ENOG4105E5Q amino acid AbC transporter BS1321_21655 ENOG4105CDA abc transporter atp-binding protein BS1321_21660 ENOG4108QEG Membrane BS1321_21665 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BS1321_21670 ENOG4108ZVT methylmalonyl-coA epimerase BS1321_21675 ENOG4108HNZ carboxyl transferase BS1321_21680 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BS1321_21690 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS1321_21695 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BS1321_21705 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BS1321_21740 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase BS1321_21745 ENOG4105II7 pyrroline-5-carboxylate reductase BS1321_21750 ENOG41069FQ Metallo-beta-lactamase superfamily BS1321_21755 ENOG4108IXY short-chain dehydrogenase reductase BS1321_21770 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BS1321_21780 ENOG4106HZJ BS1321_21795 ENOG4105K56 Transcriptional regulator BS1321_21805 ENOG4105CPC Aldo Keto reductase BS1321_21825 ENOG4105MZ9 stage II sporulation protein m BS1321_21830 ENOG4105I3K Ferric uptake regulator, Fur family BS1321_21840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS1321_21860 ENOG4105DZ1 carboxypeptidase BS1321_21865 ENOG41082AN stage II sporulation protein BS1321_21870 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BS1321_21875 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BS1321_21880 ENOG4105C7N Xanthine uracil vitamin C permease BS1321_21895 ENOG4105G6R Stage v sporulation protein ae BS1321_21910 ENOG4105PTM secreted protein BS1321_21925 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BS1321_21930 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BS1321_21945 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BS1321_21950 ENOG4105D3R alkyl hydroperoxide reductase BS1321_21960 ENOG4105DZ1 carboxypeptidase BS1321_21965 ENOG4108JIC nucleoside recognition domain protein BS1321_21975 ENOG4105FE9 pseudouridine synthase BS1321_21980 ENOG4105KJP alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BS1321_21985 ENOG4107TWT Cytochrome c biogenesis protein BS1321_21990 ENOG4105CRE cytochrome C BS1321_21995 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_22000 ENOG4105BZU Histidine kinase BS1321_22015 ENOG4108JQ1 Dehydrogenase BS1321_22020 ENOG4108SAX Membrane BS1321_22030 ENOG4105T7X BS1321_22035 ENOG4105C9U ATP-dependent DNA helicase RecQ BS1321_22040 ENOG4105I7S Abortive infection protein BS1321_22055 ENOG4107RGJ metallophosphoesterase BS1321_22075 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BS1321_22080 ENOG4105HDK L-asparaginase BS1321_22090 ENOG4105F0V Cell wall hydrolase BS1321_22095 ENOG4105MSI germination protein ypeb BS1321_22110 ENOG4105CAT Cytidine monophosphate kinase BS1321_22115 ENOG4105E9Q Acyl-transferase BS1321_22120 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BS1321_22145 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BS1321_22150 ENOG4105CUB amino acid BS1321_22160 ENOG4108JUB Transcriptional regulator BS1321_22180 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BS1321_22185 ENOG4105K70 DNA-binding protein BS1321_22190 ENOG4105EUJ GTP cyclohydrolase i BS1321_22200 ENOG4105XXQ heptaprenyl diphosphate synthase component I BS1321_22205 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BS1321_22210 ENOG4105EAH synthase BS1321_22215 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BS1321_22220 ENOG4105BZU Histidine kinase BS1321_22225 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BS1321_22230 ENOG4105D49 3-dehydroquinate synthase BS1321_22235 ENOG4105KHN chorismate mutase BS1321_22240 ENOG4105CIH Imidazole acetol-phosphate transaminase BS1321_22250 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BS1321_22255 ENOG41068YB TPR repeat-containing protein BS1321_22270 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) BS1321_22275 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BS1321_22300 ENOG4108JYZ YitT family BS1321_22305 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BS1321_22315 ENOG4108Z5K methylglyoxal synthase BS1321_22320 ENOG4105FJR Lmbe family BS1321_22325 ENOG4105CPK Glycosyl transferase (Group 1 BS1321_22330 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BS1321_22340 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BS1321_22345 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) BS1321_22350 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BS1321_22355 ENOG4105DVT helicase BS1321_22360 ENOG4105YAC BS1321_22370 ENOG4105CHM Aminotransferase BS1321_22380 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS1321_22385 ENOG4105C26 Dehydrogenase BS1321_22395 ENOG4105DTN riboflavin biosynthesis protein ribF BS1321_22410 ENOG4106P55 Transcriptional regulator BS1321_22430 ENOG4105ERH Fumarylacetoacetate hydrolase BS1321_22445 ENOG4105C5S asparaginyl-tRNA synthetase BS1321_22455 ENOG4105CSM endonuclease III BS1321_22465 ENOG4105BZ4 penicillin-binding protein BS1321_22495 ENOG4105MYT Heat shock protein BS1321_22505 ENOG4108I5C dEAD DEAH box helicase BS1321_22510 ENOG4107X2U Inherit from COG: Exonuclease-like protein BS1321_22520 ENOG4108UKS UPF0398 protein BS1321_22525 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BS1321_22535 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BS1321_22545 ENOG4105DVT helicase BS1321_22550 ENOG4105CTD carboxy-peptidase BS1321_22560 ENOG4105C2W permease BS1321_22570 ENOG41065KQ synthase BS1321_22580 ENOG410890F Dynamin family BS1321_22590 ENOG4105KHC sulfurtransferase BS1321_22610 ENOG41081VK Ribonuclease BS1321_22630 ENOG4105KPV Transcriptional regulator BS1321_22645 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BS1321_22665 ENOG4108JQ1 Dehydrogenase BS1321_22675 ENOG4105E1V na solute symporter BS1321_22680 ENOG4105C7K acetolactate synthase BS1321_22690 ENOG4108IQI permease BS1321_22700 ENOG4105DVW rieske (2Fe-2S) BS1321_22745 ENOG4105E1K spore germination protein BS1321_22785 ENOG4105CUB amino acid BS1321_22790 ENOG4105D82 Glutamate dehydrogenase BS1321_22810 ENOG4105CEU Arginine dihydrolase BS1321_22830 ENOG4106V2I dimethylaminohydrolase BS1321_22835 ENOG4108IQI permease BS1321_22870 ENOG4105E3J oxidoreductase BS1321_22875 ENOG4105C26 Dehydrogenase BS1321_22885 ENOG4105C0A alcohol dehydrogenase BS1321_22895 ENOG4105C26 Dehydrogenase BS1321_22905 ENOG4105F32 YngK protein BS1321_22920 ENOG4105CK1 PTS System BS1321_22930 ENOG4105F8D glycoside hydrolase family 4 BS1321_22935 ENOG4105VCP PTS System BS1321_22945 ENOG4105RD7 BadF BadG BcrA BcrD BS1321_22950 ENOG4106KNT transcriptional regulator BS1321_22955 ENOG4105FDP GntR family transcriptional regulator BS1321_22965 ENOG4108RZE Tetr family transcriptional regulator BS1321_23005 ENOG4105FDP GntR family transcriptional regulator BS1321_23010 ENOG4105ETE Transcriptional regulator (LacI family BS1321_23025 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BS1321_23030 ENOG4105DRS transport system, permease BS1321_23035 ENOG4105DKQ ROK family BS1321_23040 ENOG4105E70 isomerase BS1321_23050 ENOG4105D2M Aldolase BS1321_23055 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB BS1321_23060 ENOG4105ETZ PTS System BS1321_23065 ENOG4105F3R pts system mannose fructose sorbose family iid BS1321_23075 ENOG4105CE4 GlcNAc 6-P deacetylase BS1321_23095 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BS1321_23130 ENOG4108WYP Transcriptional regulator BS1321_23135 ENOG4107VAM peptidase, m28 BS1321_23140 ENOG4105F38 ABC transporter, permease BS1321_23145 ENOG4105ECW sulfate abc transporter BS1321_23150 ENOG4105DP9 ABC transporter BS1321_23165 ENOG4105VUF Transcriptional regulator BS1321_23170 ENOG4105F27 Major Facilitator BS1321_23175 ENOG4105DQ4 alcohol dehydrogenase BS1321_23185 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BS1321_23190 ENOG4108N23 SpoOM-related protein BS1321_23195 ENOG4105K4H Nlp p60 protein BS1321_23205 ENOG4105KME endoribonuclease L-psp BS1321_23210 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BS1321_23215 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BS1321_23265 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BS1321_23330 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_23335 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS1321_23370 ENOG4105YWU small acid-soluble spore protein BS1321_23380 ENOG4105VRR gCN5-related N-acetyltransferase BS1321_23405 ENOG4107STQ Multicopper oxidase BS1321_23425 ENOG4105KST dependent repressor BS1321_23430 ENOG4108D32 Methyltransferase BS1321_23440 ENOG4105CVG Homoserine O-transsuccinylase BS1321_23450 ENOG4108V06 Glutathione peroxidase BS1321_23455 ENOG4105EPR degv family BS1321_23465 ENOG4105C5H ABC transporter BS1321_23475 ENOG4105C01 Dihydroxy-acid dehydratase BS1321_23480 ENOG4108Y6J UPF0403 protein BS1321_23485 ENOG4107YX5 Pfam:DUF548 BS1321_23490 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BS1321_23500 ENOG4107TS3 membrane protein, TerC BS1321_23505 ENOG4105NAE bifunctional deaminase-reductase domain protein BS1321_23520 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BS1321_23525 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BS1321_23530 ENOG4105C7B Threonine dehydratase BS1321_23535 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_23540 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BS1321_23550 ENOG4108RCR degv family BS1321_23555 ENOG4108KF3 Electron transport protein SCO1 SenC BS1321_23560 ENOG41090WU lipolytic protein G-D-S-L family BS1321_23575 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BS1321_23580 ENOG4105E0X reductase BS1321_23710 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS1321_23725 ENOG4107S4Y M20 DapE family protein YgeY BS1321_23730 ENOG4108TSC N-acetyltransferase BS1321_23735 ENOG4108JUB Transcriptional regulator BS1321_23740 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BS1321_23755 ENOG4105BZU Histidine kinase BS1321_23770 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BS1321_23780 ENOG4108KGH TRANSCRIPTIONal BS1321_23785 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BS1321_23790 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) BS1321_23795 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BS1321_23805 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BS1321_23810 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BS1321_23815 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BS1321_23820 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BS1321_23825 ENOG4105CKI cobalamin synthesis protein BS1321_23840 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_23845 ENOG4105BZU Histidine kinase BS1321_23855 ENOG4105K4I Scp-like extracellular BS1321_23870 ENOG4107QMU Mate efflux family protein BS1321_23875 ENOG4105D64 Mechanosensitive ion channel BS1321_23880 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BS1321_23885 ENOG41067MG lrgb family BS1321_23890 ENOG4105VAW lrga family BS1321_23915 ENOG4108V2W Carbonate dehydratase BS1321_23925 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BS1321_23930 ENOG4105DQE DNA ligase BS1321_23935 ENOG4105FDF Could be involved in DNA repair (By similarity) BS1321_23940 ENOG4108RPX mosc domain containing protein BS1321_23955 ENOG4107VMI polysaccharide deacetylase BS1321_23960 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BS1321_23965 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BS1321_23970 ENOG4105C7S Dehydrogenase BS1321_23975 ENOG4105E98 transcriptional regulator DeoR family BS1321_23980 ENOG4105DE4 1-phosphofructokinase BS1321_23985 ENOG4105DM4 PTS System BS1321_24005 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BS1321_24015 ENOG4105F0V Cell wall hydrolase BS1321_24020 ENOG4105KTU Transcriptional regulator, arsr family BS1321_24025 ENOG4108UT2 hemolysin iii BS1321_24035 ENOG4105VKD bioY protein BS1321_24045 ENOG4105DZ6 Band 7 protein BS1321_24070 ENOG4108TVJ Nitroreductase BS1321_24075 ENOG4105FS7 Transcriptional regulator BS1321_24110 ENOG4108Q8B Spore germination protein BS1321_24115 ENOG4105E1K spore germination protein BS1321_24145 ENOG4105E1K spore germination protein BS1321_24155 ENOG4105C5H ABC transporter BS1321_24160 ENOG4105HHM rdd domain containing protein BS1321_24170 ENOG4105EEM helicase BS1321_24190 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BS1321_24200 ENOG4105QNR S1 RNA binding domain protein BS1321_24205 ENOG4105WEF catalase BS1321_24220 ENOG41069ER domain protein BS1321_24225 ENOG4105C9U ATP-dependent DNA helicase RecQ BS1321_24240 ENOG4108JYZ YitT family BS1321_24245 ENOG4105BZU Histidine kinase BS1321_24250 ENOG4105D8G Major Facilitator superfamily BS1321_24260 ENOG4105CJ1 ABC, transporter BS1321_24265 ENOG4108TU7 Inherit from COG: (ABC) transporter BS1321_24280 ENOG41080XQ Signal transduction protein with cbs domains BS1321_24285 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BS1321_24300 ENOG4105KVH Transcriptional regulator BS1321_24325 ENOG4106AUC UPF0180 protein BS1321_24330 ENOG4108X3M OsmC Ohr family protein BS1321_24360 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BS1321_24365 ENOG4105FBA Phospholipase Carboxylesterase BS1321_24370 ENOG4107XWI flavin reductase domain protein, FMN-binding BS1321_24375 ENOG4108IQI permease BS1321_24380 ENOG4108J5H Homocysteine s-methyltransferase BS1321_24385 ENOG4108IMY Transcriptional regulator BS1321_24390 ENOG4105HDK L-asparaginase BS1321_24395 ENOG4108IJ0 Aspartate ammonia-lyase BS1321_24410 ENOG4105XTG Pfam:DUF156 BS1321_24415 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS1321_24420 ENOG410904N short-chain dehydrogenase reductase BS1321_24425 ENOG4105VRS hydrolase family 18 BS1321_24435 ENOG4105D7V transposase BS1321_24440 ENOG4105BZ1 (ABC) transporter BS1321_24445 ENOG4105DG6 mannose-6-phosphate isomerase BS1321_24450 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BS1321_24455 ENOG4105C1B dTDP-glucose 4-6-dehydratase BS1321_24460 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BS1321_24465 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BS1321_24480 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BS1321_24485 ENOG4105C0K Gdp-mannose 4,6-dehydratase BS1321_24530 ENOG4107QQG Dehydrogenase BS1321_24595 ENOG4106U2H Protein of unknown function (DUF1360) BS1321_24600 ENOG4105CIS alcohol dehydrogenase BS1321_24605 ENOG41068WN BS1321_24615 ENOG4105W4W Transcriptional regulator BS1321_24620 ENOG4105DJB Major Facilitator Superfamily BS1321_24630 ENOG4105EJQ L-serine dehydratase BS1321_24645 ENOG4105BZU Histidine kinase BS1321_24650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BS1321_24655 ENOG4107SNB ankyrin repeat protein YahD BS1321_24665 ENOG4105C8Q Methyl-accepting chemotaxis BS1321_24670 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit BS1321_24675 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter BS1321_24680 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BS1321_24685 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BS1321_24695 ENOG4105C01 Dihydroxy-acid dehydratase BS1321_24700 ENOG4107HP6 Transcriptional regulator BS1321_24710 ENOG4105CTX dehydratase BS1321_24715 ENOG4105CTX dehydratase BS1321_24720 ENOG4105C26 Dehydrogenase BS1321_24725 ENOG4105CXK mandelate racemase muconate lactonizing BS1321_24730 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BS1321_24745 ENOG4105ERH Fumarylacetoacetate hydrolase BS1321_24755 ENOG4105DTC 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase BS1321_24760 ENOG4105C8M UPF0272 protein BS1321_24765 ENOG4105C8M UPF0272 protein BS1321_24785 ENOG4105DG4 malate L-lactate dehydrogenase BS1321_24790 ENOG4105CPQ Dehydrogenase BS1321_24795 ENOG4108UHU Aldolase BS1321_24800 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BS1321_24805 ENOG4105DMW Dehydrogenase reductase BS1321_24815 ENOG4108I5G Major Facilitator superfamily BS1321_24820 ENOG4105UEI Transcriptional Regulator AraC Family BS1321_24825 ENOG4105CTX dehydratase BS1321_24830 ENOG4105CPQ Dehydrogenase BS1321_24835 ENOG4107QZW Altronate oxidoreductase BS1321_24840 ENOG4108ZCF integral membrane protein BS1321_24845 ENOG4105C26 Dehydrogenase BS1321_24855 ENOG4105CUX Signal transduction histidine kinase BS1321_24860 ENOG4105C85 amino acid BS1321_24875 ENOG41076HS cation diffusion facilitator family transporter BS1321_24890 ENOG4105ECB domain protein BS1321_24895 ENOG4107S1V Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BS1321_24910 ENOG4105K4I Scp-like extracellular BS1321_24930 ENOG4108J59 Extracellular solute-binding protein, family 5 BS1321_24935 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BS1321_24940 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BS1321_24950 ENOG4108JQ7 (ABC) transporter BS1321_24955 ENOG4105E39 Enoyl-CoA hydratase BS1321_24970 ENOG41068WN BS1321_24975 ENOG4105C26 Dehydrogenase BS1321_24980 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BS1321_24995 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BS1321_25005 ENOG4107Y2X deaminase BS1321_25010 ENOG4107TT2 Auxin Efflux Carrier BS1321_25020 ENOG4105CDA abc transporter atp-binding protein BS1321_25025 ENOG4105CT1 (ABC) transporter BS1321_25030 ENOG4105EAD ABC transporter BS1321_25035 ENOG4105DRP amino acid AbC transporter BS1321_25060 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BS1321_25070 ENOG4105C02 permease BS1321_25075 ENOG4105FCD Major Facilitator BS1321_25080 ENOG4105CM2 brancheD-chain amino acid aminotransferase BS1321_25090 ENOG4105WH1 Two component transcriptional regulator luxr family BS1321_25120 ENOG4105DPN Oligoendopeptidase f BS1321_25130 ENOG4105DEN Luciferase family BS1321_25135 ENOG4105DEN Luciferase family BS1321_25140 ENOG4105CRQ synthase (Component I) BS1321_25145 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BS1321_25150 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BS1321_25155 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BS1321_25170 ENOG4108UZX fmn reductase BS1321_25180 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BS1321_25185 ENOG4107RIQ Sulfate adenylate transferase BS1321_25190 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) BS1321_25195 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BS1321_25205 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS1321_25210 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BS1321_25215 ENOG4108Z73 Siroheme synthase BS1321_25220 ENOG410635A Membrane BS1321_25225 ENOG4108VCA G U mismatch-specific DNA glycosylase BS1321_25245 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BS1321_25250 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) BS1321_25260 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BS1321_25265 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BS1321_25270 ENOG4105CGK Exodeoxyribonuclease III BS1321_25280 ENOG4108U5N UPF0316 protein BS1321_25290 ENOG4107TB6 phosphoglycerate mutase BS1321_25295 ENOG4105K4T epimerase BS1321_25305 ENOG4105D0M Protease HtpX homolog BS1321_25340 ENOG4107T8Q Glycosyl transferase (Group 1 BS1321_25365 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BS1321_25370 ENOG4105C6Y Udp-glucose 6-dehydrogenase BS1321_25395 ENOG4107T8Q Glycosyl transferase (Group 1 BS1321_25415 ENOG4108RWP Major Facilitator Superfamily protein BS1321_25430 ENOG4105NQC Flavodoxin BS1321_25440 ENOG4105C1G acyl-Coa dehydrogenase BS1321_25445 ENOG4108IJ8 ABC transporter BS1321_25450 ENOG4105E90 ABC transporter BS1321_25455 ENOG4108HQR Glycine betaine BS1321_25460 ENOG4105R40 Glycine betaine carnitine choline BS1321_25465 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BS1321_25470 ENOG4105HMI Membrane BS1321_25475 ENOG4105DUM transcriptional regulator, lysR family BS1321_25505 ENOG4108IUM Glycogen debranching enzyme BS1321_25510 ENOG4108IEG Formate dehydrogenase Alpha subunit BS1321_25515 ENOG4108IEG Formate dehydrogenase Alpha subunit BS1321_25525 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BS1321_25535 ENOG4105E1K spore germination protein BS1321_25540 ENOG4108Q5U germination protein, ger(x)c family BS1321_25580 ENOG4108PVQ transcriptional regulator BS1321_25585 ENOG4105D5U fad dependent oxidoreductase BS1321_25595 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) BS1321_25605 ENOG4108UB7 BS1321_25615 ENOG4107VFR oxidoreductase BS1321_25635 ENOG4105CBC glutamate synthase BS1321_25640 ENOG4105G9B Transcriptional regulator BS1321_25645 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BS1321_25650 ENOG4105BZW Glycerate kinase BS1321_25655 ENOG4105C6Z Gluconate BS1321_25660 ENOG4105DQ6 Transposase BS1321_25690 ENOG4105D8X mechanosensitive ion channel BS1321_25700 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BS1321_25710 ENOG4108XRC Protein of unknown function (DUF458) BS1321_25715 ENOG4105CMD Transcriptional regulator, GntR family BS1321_25725 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BS1321_25735 ENOG4105DME alpha-galactosidase BS1321_25740 ENOG4105EF1 ribulokinase BS1321_25765 ENOG4108IFG nitrite reductase, (NAD(P)H) BS1321_25770 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BS1321_25775 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BS1321_25785 ENOG4108IFG nitrite reductase, (NAD(P)H) BS1321_25790 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BS1321_25820 ENOG41082BM Transcriptional regulator, arsr family BS1321_25825 ENOG4105CZ9 Domain of unknown function (DU1801) BS1321_25835 ENOG4105BZU Histidine kinase BS1321_25840 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BS1321_25855 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BS1321_25860 ENOG4105F38 ABC transporter, permease BS1321_25865 ENOG4105D38 putrescine abc transporter BS1321_25875 ENOG4105CQB FAD linked oxidase domain protein BS1321_25880 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BS1321_25885 ENOG4105N14 lysine exporter protein LysE YggA BS1321_25890 ENOG4108NGU Transcriptional regulator BS1321_25900 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BS1321_25905 ENOG4107XBN GntR Family Transcriptional Regulator BS1321_25910 ENOG4108UZ3 Transporter BS1321_25915 ENOG4105EMU Dehydrogenase BS1321_25925 ENOG4105VUF Transcriptional regulator BS1321_25930 ENOG4105BZU Histidine kinase BS1321_25945 ENOG4108YYS metal-dependent hydrolase (By similarity) BS1321_25975 ENOG4105EA8 2-Nitropropane dioxygenase BS1321_25980 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BS1321_25985 ENOG4105CHR reductase BS1321_25995 ENOG4107QKR Dehydrogenase BS1321_26005 ENOG4107RUY (E1 component), alpha subunit BS1321_26015 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BS1321_26020 ENOG4108HGU Histidine kinase BS1321_26025 ENOG4105FDT acyl-CoA dehydrogenase BS1321_26040 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BS1321_26090 ENOG4105CHR reductase BS1321_26100 ENOG4105DRR Transcriptional regulator, GntR family BS1321_26110 ENOG4105E6M Sulphatase-modifying factor protein BS1321_26120 ENOG4108PCX Major Facilitator BS1321_26125 ENOG4105BZU Histidine kinase BS1321_26145 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BS1321_26150 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BS1321_26155 ENOG4105GPN Uncharacterized conserved protein (DUF2294) BS1321_26170 ENOG4105E1V na solute symporter BS1321_26175 ENOG4106CAD Protein of unknown function (DUF3311) BS1321_26180 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BS1321_26210 ENOG4108IQI permease BS1321_26265 ENOG4105BZU Histidine kinase BS1321_26285 ENOG4105SX7 Transporter BS1321_26290 ENOG4105KK4 UPF0060 membrane protein BS1321_26295 ENOG4105D2S major facilitator superfamily BS1321_26305 ENOG4105D2S major facilitator superfamily BS1321_26315 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BS1321_26320 ENOG4106YBV Methyl-accepting chemotaxis BS1321_26325 ENOG4105CUB amino acid BS1321_26330 ENOG4108R1P BS1321_26345 ENOG4108IG5 Transcriptional regulator BS1321_26375 ENOG4107R6F Alpha Beta Hydrolase Fold protein BS1321_26380 ENOG4108MJI response regulator BS1321_26395 ENOG41090U3 tautomerase BS1321_26400 ENOG4105ID8 Transcriptional regulator, ARAC family BS1321_26405 ENOG4107QNK )-transporter BS1321_26410 ENOG4105CIB oxidoreductase Domain protein BS1321_26415 ENOG4107QP6 Xylose isomerase domain protein TIM barrel BS1321_26420 ENOG4105D7V transposase BS1321_26500 ENOG4107S1E Beta-lactamase BS1321_26505 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BS1321_26510 ENOG4105DAP Nicotinate phosphoribosyltransferase BS1321_26525 ENOG4107QX3 carboxylase BS1321_26530 ENOG4105E39 Enoyl-CoA hydratase BS1321_26535 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BS1321_26540 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BS1321_26545 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BS1321_26550 ENOG4105CEY Amp-dependent synthetase and ligase BS1321_26555 ENOG4105C1G acyl-Coa dehydrogenase BS1321_26590 ENOG4108S4H thioesterase Superfamily protein BS1321_26610 ENOG4108NHD germination protein BS1321_26630 ENOG4108B31 Spore germination protein BS1321_26650 ENOG4108VXD carboxy-peptidase BS1321_26655 ENOG4108KGH TRANSCRIPTIONal BS1321_26675 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BS1321_26690 ENOG4105C5E polysaccharide biosynthesis protein