locus-tag	class	description
UP17_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UP17_00010	COG0592	DNA-directed DNA polymerase activity
UP17_00015	COG2501	S4 domain
UP17_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
UP17_00030	COG0187	DNA topoisomerase II activity
UP17_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP17_00070	COG0516	GMP reductase activity
UP17_00070	COG0517	IMP dehydrogenase activity
UP17_00090	COG1428	Deoxynucleoside kinase
UP17_00120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UP17_00130	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UP17_00175	COG1982	Orn Lys Arg decarboxylase major
UP17_00180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
UP17_00185	COG3870	Protein conserved in bacteria
UP17_00190	COG1728	Protein conserved in bacteria
UP17_00195	COG0470	DNA polymerase III
UP17_00200	COG1774	PSP1 C-terminal conserved region
UP17_00205	COG4467	Involved in initiation control of chromosome replication
UP17_00210	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
UP17_00220	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UP17_00225	COG2002	toxin-antitoxin pair type II binding
UP17_00235	COG0084	hydrolase, TatD family'
UP17_00240	COG3584	3D domain protein
UP17_00240	COG3583	domain protein
UP17_00260	COG4466	Protein conserved in bacteria
UP17_00275	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP17_00280	COG0251	oxidation-reduction process
UP17_00285	COG2088	sporulation resulting in formation of a cellular spore
UP17_00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
UP17_00295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UP17_00305	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
UP17_00320	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UP17_00325	COG2002	toxin-antitoxin pair type II binding
UP17_00330	COG2244	polysaccharide biosynthetic process
UP17_00335	COG3956	TIGRFAM MazG family protein
UP17_00340	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UP17_00360	COG1098	S1 RNA binding domain
UP17_00375	COG2208	phosphoserine phosphatase activity
UP17_00380	COG2304	oxidoreductase activity
UP17_00385	COG0515	serine threonine protein kinase
UP17_00390	COG0037	tRNA processing
UP17_00405	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UP17_00410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
UP17_00415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP17_00420	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP17_00425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UP17_00430	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
UP17_00435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UP17_00440	COG1396	sequence-specific DNA binding
UP17_00445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP17_00450	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
UP17_00535	COG3880	PFAM UvrB UvrC protein
UP17_00540	COG3869	Catalyzes the specific phosphorylation of arginine residues in
UP17_00545	COG0542	response to heat
UP17_00550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UP17_00560	COG4956	integral membrane protein (PIN domain superfamily)
UP17_00570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UP17_00575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UP17_00585	COG1045	serine acetyltransferase
UP17_00590	COG0215	cysteine-tRNA ligase activity
UP17_00600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP17_00605	COG3688	RNA-binding protein containing a PIN domain
UP17_00615	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP17_00620	COG0250	Participates in transcription elongation, termination and antitermination
UP17_00630	COG0081	regulation of translation
UP17_00645	COG2813	Specifically methylates the guanine in position
UP17_00650	COG0085	RNA polymerase activity
UP17_00655	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
UP17_00660	COG1358	cellular component organization or biogenesis
UP17_00665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UP17_00670	COG0049	tRNA binding
UP17_00675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
UP17_00685	COG0051	transcription antitermination factor activity, RNA binding
UP17_00690	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UP17_00695	COG0088	Forms part of the polypeptide exit tunnel
UP17_00705	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
UP17_00710	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UP17_00715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
UP17_00720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UP17_00725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UP17_00730	COG0255	Belongs to the universal ribosomal protein uL29 family
UP17_00735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UP17_00740	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UP17_00745	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UP17_00755	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP17_00760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UP17_00765	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UP17_00770	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UP17_00775	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UP17_00780	COG1841	ribosomal large subunit assembly
UP17_00790	COG0201	protein transport
UP17_00800	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UP17_00805	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UP17_00810	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
UP17_00815	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UP17_00820	COG0202	RNA polymerase activity
UP17_00825	COG0203	ribosomal protein L17
UP17_00830	COG1122	ATPase activity
UP17_00835	COG1122	ATPase activity
UP17_00840	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
UP17_00855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UP17_00870	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP17_00875	COG0489	protein tyrosine kinase activity
UP17_00885	COG2194	sulfuric ester hydrolase activity
UP17_00890	COG0726	polysaccharide deacetylase
UP17_00970	COG1595	DNA-templated transcription, initiation
UP17_00975	COG5662	AntiSigma factor
UP17_00980	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
UP17_00985	COG4856	YbbR-like protein
UP17_00990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_00995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UP17_01000	COG5646	InterPro IPR014922
UP17_01015	COG5002	protein histidine kinase activity
UP17_01025	COG1132	(ABC) transporter
UP17_01040	COG1278	Cold shock
UP17_01060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UP17_01065	COG0493	'glutamate synthase
UP17_01070	COG0167	dihydroorotate dehydrogenase activity
UP17_01090	COG3835	regulator
UP17_01095	COG1597	lipid kinase activity
UP17_01100	COG0025	NhaP-type Na H and K H
UP17_01120	COG3842	ATPase activity
UP17_01125	COG1176	ABC-type spermidine putrescine transport system, permease component I
UP17_01135	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
UP17_01140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP17_01160	COG4821	SIS domain
UP17_01170	COG0363	glucosamine-6-phosphate deaminase activity
UP17_01175	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP17_01180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_01180	COG2190	(PTS) system
UP17_01180	COG1263	PTS System
UP17_01185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UP17_01200	COG2814	Major facilitator Superfamily
UP17_01205	COG1846	Transcriptional regulator
UP17_01210	COG2822	iron ion transport
UP17_01215	COG2837	iron assimilation
UP17_01220	COG0672	)-iron permease
UP17_01230	COG0789	Transcriptional regulator
UP17_01235	COG1253	flavin adenine dinucleotide binding
UP17_01245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UP17_01250	COG2208	phosphoserine phosphatase activity
UP17_01290	COG4974	Belongs to the 'phage' integrase family
UP17_01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP17_01305	COG1597	lipid kinase activity
UP17_01335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UP17_01345	COG0513	Belongs to the DEAD box helicase family
UP17_01350	COG3402	PFAM membrane-flanked domain
UP17_01355	COG3428	Bacterial PH domain
UP17_01360	COG0705	Rhomboid family
UP17_01365	COG0736	holo-[acyl-carrier-protein] synthase activity
UP17_01370	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UP17_01380	COG0864	Transcriptional regulator
UP17_01385	COG2337	Toxic component of a toxin-antitoxin (TA) module
UP17_01390	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_01395	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_01400	COG2172	sigma factor antagonist activity
UP17_01405	COG2208	phosphoserine phosphatase activity
UP17_01410	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_01415	COG2172	sigma factor antagonist activity
UP17_01420	COG1191	sigma factor activity
UP17_01425	COG2208	phosphoserine phosphatase activity
UP17_01430	COG2183	response to ionizing radiation
UP17_01515	COG0802	atpase or kinase
UP17_01520	COG1214	PFAM Peptidase M22, glycoprotease
UP17_01525	COG0456	acetyltransferase
UP17_01535	COG0488	(ABC) transporter
UP17_01540	COG0315	cyclic pyranopterin monophosphate synthase activity
UP17_01545	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
UP17_01555	COG1266	CAAX protease self-immunity
UP17_01575	COG2205	protein histidine kinase activity
UP17_01585	COG3104	oligopeptide transport
UP17_01600	COG1070	Carbohydrate kinase
UP17_01610	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UP17_01630	COG0772	Belongs to the SEDS family
UP17_01640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_01640	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP17_01655	COG2318	DinB family
UP17_01685	COG2964	Protein conserved in bacteria
UP17_01690	COG0251	oxidation-reduction process
UP17_01695	COG2271	Major facilitator Superfamily
UP17_01730	COG0531	amino acid
UP17_01735	COG0697	spore germination
UP17_01740	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
UP17_01755	COG2986	histidine ammonia-lyase
UP17_01760	COG0833	amino acid
UP17_01765	COG0825	malonyl-CoA metabolic process
UP17_01770	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UP17_01785	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP17_01790	COG1288	antiporter activity
UP17_01800	COG4175	Glycine betaine
UP17_01800	COG0517	IMP dehydrogenase activity
UP17_01820	COG1957	nucleoside hydrolase
UP17_01825	COG4842	Belongs to the WXG100 family
UP17_01830	COG5417	Belongs to the EsaB family
UP17_01835	COG4499	WXG100 protein secretion system (Wss), protein YukC
UP17_01840	COG1674	ftsk spoiiie
UP17_01845	COG1511	domain protein
UP17_01855	COG0714	Associated with various cellular activities
UP17_01865	COG1305	Transglutaminase-like
UP17_01870	COG0519	Catalyzes the synthesis of GMP from XMP
UP17_01870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
UP17_01875	COG2252	PERMEase
UP17_01880	COG3711	transcriptional antiterminator
UP17_01885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_01885	COG2190	(PTS) system
UP17_01885	COG1263	PTS System
UP17_01925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UP17_01950	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UP17_01955	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
UP17_01960	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UP17_01970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UP17_01975	COG0047	phosphoribosylformylglycinamidine synthase activity
UP17_01985	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UP17_01995	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UP17_02005	COG0151	Belongs to the GarS family
UP17_02020	COG1470	cell adhesion involved in biofilm formation
UP17_02025	COG4496	protein, YerC YecD
UP17_02030	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
UP17_02035	COG0210	DNA helicase
UP17_02040	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UP17_02045	COG4851	CamS sex pheromone cAM373 precursor
UP17_02050	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP17_02055	COG0154	amidase activity
UP17_02060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UP17_02070	COG1597	lipid kinase activity
UP17_02075	COG0456	acetyltransferase
UP17_02090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_02095	COG2323	membrane
UP17_02110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_02145	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
UP17_02150	COG3853	Toxic anion resistance protein (TelA)
UP17_02160	COG0653	protein targeting
UP17_02165	COG1404	Belongs to the peptidase S8 family
UP17_02170	COG4549	nuclear export factor GLE1
UP17_02175	COG2372	response to copper ion
UP17_02175	COG1276	copper resistance
UP17_02180	COG5002	protein histidine kinase activity
UP17_02190	COG4708	membrane
UP17_02195	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UP17_02215	COG2204	response regulator
UP17_02220	COG3852	Histidine kinase
UP17_02230	COG2234	aminopeptidase activity
UP17_02255	COG0577	efflux transmembrane transporter activity
UP17_02260	COG1136	(ABC) transporter
UP17_02270	COG2226	methyltransferase
UP17_02270	COG1073	alpha beta
UP17_02275	COG0156	8-amino-7-oxononanoate synthase activity
UP17_02280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_02290	COG1653	transport
UP17_02305	COG1609	Transcriptional regulator
UP17_02315	COG0673	inositol 2-dehydrogenase activity
UP17_02320	COG0673	inositol 2-dehydrogenase activity
UP17_02330	COG1187	pseudouridine synthase activity
UP17_02340	COG0667	Aldo Keto reductase
UP17_02345	COG1114	Component of the transport system for branched-chain amino acids
UP17_02360	COG1129	ABC transporter
UP17_02365	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP17_02380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP17_02400	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
UP17_02410	COG1845	cytochrome c oxidase, subunit III
UP17_02435	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UP17_02440	COG0527	aspartate kinase activity
UP17_02445	COG0778	Nitroreductase
UP17_02455	COG1132	(ABC) transporter
UP17_02460	COG1132	(ABC) transporter
UP17_02475	COG1966	Carbon starvation protein
UP17_02485	COG0004	ammonium transporteR
UP17_02490	COG0347	Belongs to the P(II) protein family
UP17_02500	COG3279	Response regulator of the LytR AlgR family
UP17_02505	COG0427	acetyl-CoA hydrolase
UP17_02510	COG0628	permease
UP17_02515	COG1012	belongs to the aldehyde dehydrogenase family
UP17_02520	COG1301	dicarboxylic acid transport
UP17_02525	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UP17_02530	COG1388	LysM domain
UP17_02530	COG3584	3D domain protein
UP17_02535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_02565	COG2027	D-alanyl-D-alanine carboxypeptidase
UP17_02570	COG0546	phosphoglycolate phosphatase activity
UP17_02580	COG0778	Nitroreductase
UP17_02590	COG1012	belongs to the aldehyde dehydrogenase family
UP17_02600	COG0243	molybdopterin cofactor binding
UP17_02605	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_02610	COG5002	protein histidine kinase activity
UP17_02615	COG0513	Belongs to the DEAD box helicase family
UP17_02625	COG0626	cystathionine gamma-synthase activity
UP17_02635	COG0307	riboflavin synthase, alpha
UP17_02650	COG2404	hydrolase activity, acting on ester bonds
UP17_02655	COG1295	ribonuclease BN
UP17_02665	COG0475	glutathione-regulated potassium exporter activity
UP17_02670	COG0490	domain, Protein
UP17_02675	COG0582	viral genome integration into host DNA
UP17_02680	COG1077	Cell shape determining protein MreB Mrl
UP17_02690	COG3180	Ammonia monooxygenase
UP17_02695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UP17_02700	COG1360	Flagellar Motor Protein
UP17_02705	COG0693	protein deglycase activity
UP17_02710	COG0024	Methionine aminopeptidase
UP17_02720	COG1763	Mo-molybdopterin cofactor biosynthetic process
UP17_02725	COG0303	'Molybdopterin
UP17_02730	COG4840	Belongs to the UPF0435 family
UP17_02740	COG1295	ribonuclease BN
UP17_02750	COG2217	Heavy metal translocating P-type atpase
UP17_02755	COG0477	Major facilitator Superfamily
UP17_02760	COG0387	Pfam Sodium calcium exchanger
UP17_02770	COG0535	radical SAM domain protein
UP17_02800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UP17_02805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
UP17_02810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UP17_02815	COG4807	Protein conserved in bacteria
UP17_02825	COG0156	8-amino-7-oxononanoate synthase activity
UP17_02830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP17_02835	COG1113	amino acid transport
UP17_02845	COG1072	(Pantothenic acid kinase))
UP17_02875	COG1733	regulation of RNA biosynthetic process
UP17_02880	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP17_02905	COG1686	Belongs to the peptidase S11 family
UP17_02915	COG0579	oxidoreductase
UP17_02925	COG2801	Transposase and inactivated derivatives
UP17_02930	COG2832	Protein of unknown function (DUF454)
UP17_02935	COG2814	Major facilitator Superfamily
UP17_02990	COG3344	reverse transcriptase
UP17_03005	COG3344	reverse transcriptase
UP17_03020	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_03045	COG3344	reverse transcriptase
UP17_03070	COG1309	transcriptional regulator
UP17_03090	COG0640	Transcriptional regulator
UP17_03110	COG2801	Transposase and inactivated derivatives
UP17_03145	COG2801	Transposase and inactivated derivatives
UP17_03175	COG0662	Cupin 2, conserved barrel domain protein
UP17_03185	COG4221	oxidoreductase activity
UP17_03195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_03200	COG3344	reverse transcriptase
UP17_03205	COG2364	Membrane
UP17_03210	COG1846	Transcriptional regulator
UP17_03215	COG0456	acetyltransferase
UP17_03230	COG3344	reverse transcriptase
UP17_03255	COG2207	Transcriptional regulator
UP17_03260	COG0477	Major facilitator Superfamily
UP17_03265	COG2986	histidine ammonia-lyase
UP17_03275	COG1280	lysine exporter protein (LysE YggA)
UP17_03295	COG0789	Transcriptional regulator
UP17_03295	COG4978	Transcriptional regulator
UP17_03300	COG1811	Na channel or pump
UP17_03305	COG0425	Belongs to the sulfur carrier protein TusA family
UP17_03305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_03310	COG0477	Major facilitator Superfamily
UP17_03315	COG2814	Major facilitator Superfamily
UP17_03325	COG4413	Urea transporter
UP17_03330	COG0831	urea catabolic process
UP17_03340	COG0804	urea catabolic process
UP17_03345	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
UP17_03350	COG0830	nickel cation binding
UP17_03355	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
UP17_03360	COG0829	nickel cation binding
UP17_03385	COG1840	ABC-type Fe3 transport system, periplasmic component
UP17_03390	COG3842	ATPase activity
UP17_03400	COG0165	Argininosuccinate lyase
UP17_03415	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_03425	COG1113	amino acid transport
UP17_03430	COG1113	amino acid transport
UP17_03435	COG0531	amino acid
UP17_03440	COG0277	FAD linked oxidase domain protein
UP17_03470	COG1131	(ABC) transporter
UP17_03475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP17_03540	COG3069	C4-dicarboxylate transmembrane transporter activity
UP17_03560	COG1136	(ABC) transporter
UP17_03565	COG0577	efflux transmembrane transporter activity
UP17_03575	COG2205	protein histidine kinase activity
UP17_03580	COG0745	RESPONSE REGULATOR receiver
UP17_03590	COG1126	abc transporter atp-binding protein
UP17_03595	COG0765	amino acid transport
UP17_03600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP17_03620	COG0436	Aminotransferase
UP17_03635	COG0791	NLP P60 protein
UP17_03635	COG1388	LysM domain
UP17_03650	COG1695	Transcriptional regulator
UP17_03665	COG2814	Major facilitator Superfamily
UP17_03685	COG2124	cytochrome p450
UP17_03690	COG0166	Belongs to the GPI family
UP17_03695	COG0628	permease
UP17_03705	COG0765	amino acid transport
UP17_03710	COG1126	abc transporter atp-binding protein
UP17_03720	COG0583	DNA-binding transcription factor activity
UP17_03740	COG1960	acyl-CoA dehydrogenase activity
UP17_03745	COG0183	Belongs to the thiolase family
UP17_03760	COG1090	epimerase
UP17_03785	COG1988	membrane-bound metal-dependent
UP17_03790	COG1194	a g-specific adenine glycosylase
UP17_03800	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_03815	COG3557	Belongs to the UPF0374 family
UP17_03820	COG1132	(ABC) transporter
UP17_03835	COG0655	NAD(P)H dehydrogenase (quinone) activity
UP17_03840	COG2814	Major facilitator Superfamily
UP17_03845	COG1566	PFAM secretion protein HlyD family protein
UP17_03855	COG4129	membrane
UP17_03860	COG0067	glutamate synthase
UP17_03860	COG0070	glutamate synthase
UP17_03860	COG0069	glutamate synthase activity
UP17_03865	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP17_03875	COG4555	ABC transporter
UP17_03890	COG1607	acyl-coa hydrolase
UP17_03905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UP17_03915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_03920	COG0735	belongs to the Fur family
UP17_04045	COG0582	viral genome integration into host DNA
UP17_04070	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP17_04080	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_04110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UP17_04120	COG5577	PFAM Coat F domain
UP17_04125	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
UP17_04150	COG2162	N-hydroxyarylamine O-acetyltransferase activity
UP17_04165	COG1388	LysM domain
UP17_04225	COG0697	spore germination
UP17_04240	COG0531	amino acid
UP17_04245	COG0531	amino acid
UP17_04250	COG0725	ABC transporter, periplasmic molybdate-binding protein
UP17_04260	COG1595	DNA-templated transcription, initiation
UP17_04270	COG1011	Hydrolase
UP17_04275	COG0477	Major facilitator Superfamily
UP17_04285	COG2204	response regulator
UP17_04310	COG1309	transcriptional regulator
UP17_04315	COG0477	Major facilitator Superfamily
UP17_04330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_04345	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UP17_04355	COG0833	amino acid
UP17_04360	COG0251	oxidation-reduction process
UP17_04365	COG2515	1-aminocyclopropane-1-carboxylate deaminase
UP17_04375	COG2239	Acts as a magnesium transporter
UP17_04380	COG2130	NADP-dependent
UP17_04385	COG1289	transmembrane transporter activity
UP17_04400	COG3382	B3 4 domain protein
UP17_04405	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UP17_04410	COG2323	membrane
UP17_04420	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UP17_04425	COG0778	Nitroreductase
UP17_04435	COG0784	Response regulator, receiver
UP17_04440	COG4191	Histidine kinase
UP17_04450	COG0531	amino acid
UP17_04455	COG2766	serine protein kinase
UP17_04475	COG2807	transmembrane transport
UP17_04480	COG2186	Transcriptional regulator
UP17_04490	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_04500	COG0463	Glycosyl transferase, family 2
UP17_04510	COG0531	amino acid
UP17_04535	COG0385	Bile acid
UP17_04550	COG0778	Nitroreductase
UP17_04570	COG3961	Belongs to the TPP enzyme family
UP17_04580	COG1388	LysM domain
UP17_04580	COG0791	NLP P60 protein
UP17_04585	COG3689	TIGRFAM TIGR03943 family protein
UP17_04590	COG0701	Predicted permease
UP17_04595	COG2094	Belongs to the DNA glycosylase MPG family
UP17_04600	COG0477	Major facilitator Superfamily
UP17_04605	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_04610	COG0277	FAD linked oxidase domain protein
UP17_04615	COG0686	Belongs to the AlaDH PNT family
UP17_04620	COG2217	Heavy metal translocating P-type atpase
UP17_04625	COG2508	Transcriptional regulator
UP17_04625	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP17_04630	COG0306	phosphate transporter
UP17_04635	COG1392	Phosphate transport regulator
UP17_04640	COG0306	phosphate transporter
UP17_04645	COG0656	L-ascorbic acid biosynthetic process
UP17_04650	COG2261	transglycosylase associated protein
UP17_04655	COG0564	pseudouridine synthase activity
UP17_04675	COG3153	acetyltransferase
UP17_04675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP17_04680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_04685	COG0431	NADPH-dependent FMN reductase
UP17_04705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UP17_04715	COG1473	amidohydrolase
UP17_04725	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_04730	COG3949	Membrane
UP17_04735	COG2719	SpoVR family
UP17_04740	COG0640	Transcriptional regulator
UP17_04745	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP17_04750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UP17_04760	COG2801	Transposase and inactivated derivatives
UP17_04775	COG0398	Pfam SNARE associated Golgi protein
UP17_04780	COG0745	RESPONSE REGULATOR receiver
UP17_04785	COG5002	protein histidine kinase activity
UP17_04805	COG1522	sequence-specific DNA binding
UP17_04810	COG2059	Chromate
UP17_04815	COG2059	Chromate
UP17_04820	COG0405	Gamma-glutamyltransferase
UP17_04825	COG0697	spore germination
UP17_04840	COG0531	amino acid
UP17_04855	COG2508	Transcriptional regulator
UP17_04860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_04865	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
UP17_04870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UP17_04880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_04890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
UP17_04905	COG3396	Phenylacetate-CoA oxygenase
UP17_04930	COG1024	Enoyl-CoA hydratase
UP17_04935	COG1024	Enoyl-CoA hydratase
UP17_04940	COG1012	belongs to the aldehyde dehydrogenase family
UP17_04945	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_04950	COG0183	Belongs to the thiolase family
UP17_04955	COG1024	Enoyl-CoA hydratase
UP17_04970	COG2070	2-Nitropropane dioxygenase
UP17_04975	COG0586	Pfam SNARE associated Golgi protein
UP17_04995	COG0745	RESPONSE REGULATOR receiver
UP17_05000	COG5002	protein histidine kinase activity
UP17_05025	COG1393	Belongs to the ArsC family
UP17_05030	COG4149	molybdate abc transporter
UP17_05045	COG1278	Cold shock
UP17_05050	COG0716	FMN binding
UP17_05055	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP17_05060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP17_05065	COG1227	inorganic diphosphatase activity
UP17_05070	COG0659	secondary active sulfate transmembrane transporter activity
UP17_05085	COG2814	Major facilitator Superfamily
UP17_05090	COG2851	Citrate transporter
UP17_05110	COG0456	acetyltransferase
UP17_05120	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_05140	COG1253	flavin adenine dinucleotide binding
UP17_05145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_05155	COG0586	Pfam SNARE associated Golgi protein
UP17_05160	COG1253	flavin adenine dinucleotide binding
UP17_05165	COG3852	Histidine kinase
UP17_05170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP17_05180	COG3859	Proton-coupled thiamine transporter YuaJ
UP17_05185	COG0589	response to stress
UP17_05190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_05200	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
UP17_05220	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_05235	COG1113	amino acid transport
UP17_05240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP17_05245	COG1522	sequence-specific DNA binding
UP17_05255	COG1522	sequence-specific DNA binding
UP17_05265	COG0393	Putative heavy-metal-binding
UP17_05270	COG0753	catalase activity
UP17_05275	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
UP17_05285	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_05305	COG0516	GMP reductase activity
UP17_05305	COG0517	IMP dehydrogenase activity
UP17_05325	COG1132	(ABC) transporter
UP17_05330	COG1132	(ABC) transporter
UP17_05335	COG0254	rRNA binding
UP17_05340	COG0626	cystathionine gamma-synthase activity
UP17_05345	COG0626	cystathionine gamma-synthase activity
UP17_05350	COG0114	fumarate hydratase activity
UP17_05365	COG2508	Transcriptional regulator
UP17_05400	COG0189	ligase activity
UP17_05405	COG0189	ligase activity
UP17_05410	COG0189	ligase activity
UP17_05425	COG3679	Belongs to the UPF0342 family
UP17_05430	COG0561	phosphatase activity
UP17_05460	COG1834	amidinotransferase
UP17_05465	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_05470	COG1024	Enoyl-CoA hydratase
UP17_05490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP17_05500	COG0420	3'-5' exonuclease activity
UP17_05505	COG4717	serine-type aminopeptidase activity
UP17_05515	COG1120	ATPase activity
UP17_05535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UP17_05565	COG1846	Transcriptional regulator
UP17_05570	COG4980	gas vesicle protein
UP17_05590	COG0537	adenosine 5'-monophosphoramidase activity
UP17_05595	COG1131	(ABC) transporter
UP17_05600	COG4473	ABC transporter
UP17_05610	COG1473	amidohydrolase
UP17_05620	COG2329	Antibiotic biosynthesis monooxygenase
UP17_05625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UP17_05635	COG1309	transcriptional regulator
UP17_05640	COG1234	tRNA 3'-trailer cleavage
UP17_05645	COG0095	Lipoate-protein ligase
UP17_05650	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_05655	COG1418	mRNA catabolic process
UP17_05665	COG0501	Belongs to the peptidase M48B family
UP17_05670	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_05680	COG4903	ComK protein
UP17_05690	COG0398	Pfam SNARE associated Golgi protein
UP17_05700	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
UP17_05705	COG1074	ATP-dependent DNA helicase activity
UP17_05750	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_05755	COG2271	Major facilitator Superfamily
UP17_05760	COG2311	Membrane
UP17_05775	COG0367	asparagine synthase
UP17_05785	COG2182	Extracellular solute-binding protein
UP17_05790	COG0366	Alpha amylase catalytic
UP17_05790	COG1874	Beta-galactosidase
UP17_05795	COG0366	Alpha amylase catalytic
UP17_05800	COG1609	Transcriptional regulator
UP17_05810	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_05820	COG1307	EDD domain protein, DegV family
UP17_05825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_05835	COG0561	phosphatase activity
UP17_05840	COG1073	alpha beta
UP17_05845	COG2151	metal-sulfur cluster biosynthetic enzyme
UP17_05850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UP17_05855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
UP17_05860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
UP17_05865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
UP17_05870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UP17_05880	COG0505	Belongs to the CarA family
UP17_05890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
UP17_05905	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_05920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
UP17_05935	COG2267	carboxylic ester hydrolase activity
UP17_05955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_05960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP17_05965	COG5504	Zn-dependent protease
UP17_05975	COG0180	Tryptophanyl-tRNA synthetase
UP17_05990	COG0456	acetyltransferase
UP17_06000	COG1393	Belongs to the ArsC family
UP17_06005	COG4862	establishment of competence for transformation
UP17_06010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_06015	COG4469	Competence protein
UP17_06020	COG1164	Oligoendopeptidase f
UP17_06035	COG2346	COG2346, Truncated hemoglobins
UP17_06040	COG0741	lytic transglycosylase activity
UP17_06045	COG4116	CYTH
UP17_06050	COG2357	RelA SpoT domain protein
UP17_06055	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP17_06060	COG0564	pseudouridine synthase activity
UP17_06065	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
UP17_06070	COG2239	Acts as a magnesium transporter
UP17_06075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UP17_06120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UP17_06140	COG0210	DNA helicase
UP17_06160	COG2153	protein acetylation
UP17_06165	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
UP17_06170	COG2382	esterase
UP17_06175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP17_06195	COG0693	protein deglycase activity
UP17_06200	COG2323	membrane
UP17_06225	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UP17_06230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
UP17_06235	COG1960	acyl-CoA dehydrogenase activity
UP17_06250	COG5337	Spore coat protein CotH
UP17_06265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_06270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_06275	COG2814	Major facilitator Superfamily
UP17_06285	COG0673	inositol 2-dehydrogenase activity
UP17_06295	COG1902	pentaerythritol trinitrate reductase activity
UP17_06300	COG2723	6-phospho-beta-galactosidase activity
UP17_06305	COG0659	secondary active sulfate transmembrane transporter activity
UP17_06310	COG0789	Transcriptional regulator
UP17_06315	COG2272	Belongs to the type-B carboxylesterase lipase family
UP17_06325	COG1113	amino acid transport
UP17_06330	COG3483	tryptophan 2,3-dioxygenase activity
UP17_06335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UP17_06340	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
UP17_06350	COG4208	sulfate ABC transporter
UP17_06360	COG3883	PFAM NLP P60 protein
UP17_06360	COG0791	NLP P60 protein
UP17_06380	COG2017	converts alpha-aldose to the beta-anomer
UP17_06385	COG0531	amino acid
UP17_06405	COG1278	Cold shock
UP17_06415	COG2309	aminopeptidase activity
UP17_06420	COG1012	belongs to the aldehyde dehydrogenase family
UP17_06425	COG0477	Major facilitator Superfamily
UP17_06440	COG0352	thiamine-phosphate diphosphorylase activity
UP17_06440	COG0351	phosphomethylpyrimidine kinase
UP17_06450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP17_06465	COG1247	-acetyltransferase
UP17_06485	COG1876	peptidase activity
UP17_06490	COG1607	acyl-coa hydrolase
UP17_06495	COG0670	Belongs to the BI1 family
UP17_06505	COG4608	Belongs to the ABC transporter superfamily
UP17_06510	COG0601	transmembrane transport
UP17_06515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_06530	COG1363	Peptidase, m42
UP17_06535	COG3871	stress protein (general stress protein 26)
UP17_06550	COG4412	M6 family metalloprotease domain protein
UP17_06550	COG1404	Belongs to the peptidase S8 family
UP17_06555	COG0706	membrane insertase activity
UP17_06575	COG1764	response to oxidative stress
UP17_06580	COG1725	Transcriptional regulator
UP17_06585	COG1131	(ABC) transporter
UP17_06600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
UP17_06610	COG3290	protein histidine kinase activity
UP17_06615	COG4565	transcriptional regulatory protein
UP17_06620	COG0281	malic enzyme
UP17_06625	COG0679	Auxin Efflux Carrier
UP17_06635	COG0772	Belongs to the SEDS family
UP17_06650	COG0861	Integral membrane protein TerC family
UP17_06655	COG1191	sigma factor activity
UP17_06670	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP17_06675	COG3852	Histidine kinase
UP17_06715	COG3594	Acyltransferase
UP17_06720	COG5002	protein histidine kinase activity
UP17_06735	COG2223	nitrite transmembrane transporter activity
UP17_06740	COG3852	Histidine kinase
UP17_06745	COG1846	Transcriptional regulator
UP17_06755	COG3949	Membrane
UP17_06775	COG1525	nuclease
UP17_06780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
UP17_06785	COG0390	transport system, permease component
UP17_06790	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_06795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
UP17_06805	COG2084	Dehydrogenase
UP17_06815	COG0436	Aminotransferase
UP17_06820	COG0598	Magnesium transport protein CorA
UP17_06835	COG0835	chemotaxis
UP17_06835	COG0784	Response regulator, receiver
UP17_06850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UP17_06855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
UP17_06860	COG1408	metallophosphoesterase
UP17_06865	COG0471	metal ion transport
UP17_06865	COG0490	domain, Protein
UP17_06870	COG2200	EAL domain
UP17_06895	COG4703	Protein of unknown function (DUF1797)
UP17_06900	COG0517	IMP dehydrogenase activity
UP17_06905	COG0477	Major facilitator Superfamily
UP17_06910	COG0583	DNA-binding transcription factor activity
UP17_06915	COG2171	N-acyltransferase activity
UP17_06920	COG1473	amidohydrolase
UP17_06925	COG0569	domain protein
UP17_06930	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP17_06940	COG0561	phosphatase activity
UP17_06950	COG0497	DNA recombination
UP17_06960	COG0022	dehydrogenase e1 component
UP17_06965	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_06990	COG1982	Orn Lys Arg decarboxylase major
UP17_07000	COG4476	Belongs to the UPF0223 family
UP17_07010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UP17_07010	COG0512	Glutamine amidotransferase of anthranilate synthase
UP17_07015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UP17_07050	COG0483	inositol monophosphate 1-phosphatase activity
UP17_07080	COG4896	Protein conserved in bacteria
UP17_07090	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
UP17_07095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UP17_07100	COG4838	Belongs to the UPF0358 family
UP17_07105	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
UP17_07110	COG1612	heme a metabolic process
UP17_07115	COG0109	protoheme IX farnesyltransferase activity
UP17_07140	COG3336	cytochrome c oxidase
UP17_07155	COG2340	Cysteine-rich secretory protein family
UP17_07175	COG3679	Belongs to the UPF0342 family
UP17_07185	COG4471	UPF0298 protein
UP17_07195	COG0742	ribosomal rna small subunit methyltransferase
UP17_07200	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UP17_07205	COG3314	Sporulation integral membrane protein YlbJ
UP17_07210	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP17_07215	COG3480	Lon protease (S16) C-terminal proteolytic domain
UP17_07225	COG1323	Belongs to the UPF0348 family
UP17_07230	COG1399	metal-binding, possibly nucleic acid-binding protein
UP17_07240	COG1024	Enoyl-CoA hydratase
UP17_07250	COG0454	-acetyltransferase
UP17_07255	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
UP17_07265	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
UP17_07270	COG2001	Belongs to the MraZ family
UP17_07280	COG4839	cell division protein FtsL
UP17_07295	COG0768	penicillin binding
UP17_07305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP17_07310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UP17_07315	COG0772	Belongs to the SEDS family
UP17_07320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
UP17_07325	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
UP17_07330	COG3879	Bacterial protein of unknown function (DUF881)
UP17_07335	COG3879	Bacterial protein of unknown function (DUF881)
UP17_07340	COG3856	small basic protein
UP17_07345	COG0849	cell division
UP17_07350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UP17_07360	COG1191	sigma factor activity
UP17_07365	COG1191	sigma factor activity
UP17_07370	COG1873	PFAM PRC-barrel domain
UP17_07380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UP17_07385	COG1799	cell septum assembly
UP17_07390	COG0762	integral membrane protein
UP17_07395	COG2302	S4 RNA-binding domain
UP17_07400	COG3599	regulation of cell shape
UP17_07410	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
UP17_07415	COG0564	pseudouridine synthase activity
UP17_07420	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
UP17_07430	COG0540	Belongs to the ATCase OTCase family
UP17_07435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UP17_07440	COG0505	Belongs to the CarA family
UP17_07445	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UP17_07455	COG0167	dihydroorotate dehydrogenase activity
UP17_07465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
UP17_07475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
UP17_07480	COG1561	YicC-like family, N-terminal region
UP17_07490	COG0194	GDP metabolic process
UP17_07500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP17_07505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UP17_07520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
UP17_07520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP17_07525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UP17_07530	COG0631	protein serine/threonine phosphatase activity
UP17_07535	COG2815	serine threonine protein kinase
UP17_07535	COG0515	serine threonine protein kinase
UP17_07545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UP17_07550	COG1564	THIamine pyrophosphokinase
UP17_07560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UP17_07565	COG1302	Protein conserved in bacteria
UP17_07570	COG1461	Dihydroxyacetone kinase
UP17_07575	COG1760	l-serine dehydratase
UP17_07580	COG1760	l-serine dehydratase
UP17_07585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UP17_07590	COG1349	DNA-binding transcription factor activity
UP17_07600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UP17_07605	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_07610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP17_07615	COG0571	ribonuclease III activity
UP17_07620	COG1196	nuclear chromosome segregation
UP17_07625	COG0552	protein localization to endoplasmic reticulum
UP17_07635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UP17_07640	COG0228	four-way junction DNA binding
UP17_07645	COG1837	Belongs to the UPF0109 family
UP17_07655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UP17_07660	COG0336	Belongs to the RNA methyltransferase TrmD family
UP17_07665	COG0335	large ribosomal subunit rRNA binding
UP17_07675	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP17_07680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP17_07705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP17_07710	COG0045	succinate-CoA ligase (ADP-forming) activity
UP17_07715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UP17_07720	COG0758	DNA mediated transformation
UP17_07725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP17_07730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
UP17_07735	COG4974	Belongs to the 'phage' integrase family
UP17_07745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UP17_07750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
UP17_07755	COG1815	bacterial-type flagellum-dependent cell motility
UP17_07760	COG1558	bacterial-type flagellum-dependent cell motility
UP17_07765	COG1677	Flagellar hook-basal body complex protein FliE
UP17_07770	COG1766	The M ring may be actively involved in energy transduction
UP17_07775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP17_07780	COG1317	bacterial-type flagellum organization
UP17_07785	COG1157	protein secretion by the type III secretion system
UP17_07790	COG2882	bacterial-type flagellum organization
UP17_07805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UP17_07820	COG1582	Flagellar protein (FlbD)
UP17_07830	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP17_07835	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UP17_07835	COG1776	CheC inhibitor of MCP methylation
UP17_07840	COG2201	protein-glutamate methylesterase activity
UP17_07845	COG3190	flagellar
UP17_07850	COG1338	Plays a role in the flagellum-specific transport system
UP17_07855	COG1987	bacterial-type flagellum assembly
UP17_07860	COG1684	flagellar biosynthetic protein fliR
UP17_07865	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP17_07870	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UP17_07875	COG1419	protein localization to endoplasmic reticulum
UP17_07880	COG0455	bacterial-type flagellum organization
UP17_07885	COG2201	protein-glutamate methylesterase activity
UP17_07890	COG0643	Histidine kinase
UP17_07890	COG2198	Histidine kinase
UP17_07895	COG0835	chemotaxis
UP17_07900	COG1776	CheC inhibitor of MCP methylation
UP17_07905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
UP17_07910	COG1191	sigma factor activity
UP17_07935	COG0528	UMP kinase activity
UP17_07950	COG4589	Belongs to the CDS family
UP17_07955	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UP17_07960	COG0750	zinc metalloprotease
UP17_07970	COG2176	DNA-directed DNA polymerase activity
UP17_07975	COG0779	Required for maturation of 30S ribosomal subunits
UP17_07980	COG0195	Participates in both transcription termination and antitermination
UP17_07985	COG2740	Nucleic-acid-binding protein implicated in transcription termination
UP17_07990	COG1358	cellular component organization or biogenesis
UP17_07995	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
UP17_08000	COG1550	Protein conserved in bacteria
UP17_08005	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
UP17_08010	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
UP17_08015	COG0196	riboflavin kinase activity
UP17_08025	COG1185	polyribonucleotide nucleotidyltransferase activity
UP17_08035	COG0726	polysaccharide deacetylase
UP17_08040	COG0612	Peptidase, M16
UP17_08045	COG1873	PFAM PRC-barrel domain
UP17_08050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_08055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
UP17_08060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UP17_08065	COG0527	aspartate kinase activity
UP17_08070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP17_08075	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP17_08080	COG0740	serine-type endopeptidase activity
UP17_08090	COG4980	gas vesicle protein
UP17_08090	COG1674	ftsk spoiiie
UP17_08100	COG2188	Transcriptional regulator
UP17_08125	COG0612	Peptidase, M16
UP17_08130	COG0612	Peptidase, M16
UP17_08135	COG0300	oxidoreductase activity
UP17_08150	COG1426	Protein conserved in bacteria
UP17_08155	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
UP17_08160	COG1058	Belongs to the CinA family
UP17_08160	COG1546	Belongs to the CinA family
UP17_08170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UP17_08180	COG1692	metallophosphoesterase
UP17_08185	COG2359	stage V sporulation protein S
UP17_08195	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UP17_08195	COG0674	pyruvate-flavodoxin oxidoreductase activity
UP17_08200	COG1013	pyruvate-flavodoxin oxidoreductase activity
UP17_08210	COG1063	alcohol dehydrogenase
UP17_08215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP17_08220	COG4550	Control of competence regulator ComK, YlbF/YmcA
UP17_08240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
UP17_08245	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
UP17_08255	COG1297	OPT oligopeptide transporter protein
UP17_08270	COG0367	asparagine synthase
UP17_08280	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP17_08285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP17_08290	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP17_08295	COG1486	melibiose metabolic process
UP17_08305	COG1252	NADH dehydrogenase
UP17_08320	COG2801	Transposase and inactivated derivatives
UP17_08330	COG0745	RESPONSE REGULATOR receiver
UP17_08360	COG1923	regulation of RNA biosynthetic process
UP17_08365	COG0464	growth
UP17_08370	COG2860	membrane
UP17_08375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
UP17_08380	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
UP17_08385	COG0789	Transcriptional regulator
UP17_08390	COG0174	glutamine synthetase
UP17_08400	COG4974	Belongs to the 'phage' integrase family
UP17_08450	COG1595	DNA-templated transcription, initiation
UP17_08460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_08470	COG1131	(ABC) transporter
UP17_08485	COG1136	(ABC) transporter
UP17_08490	COG0577	efflux transmembrane transporter activity
UP17_08500	COG5002	protein histidine kinase activity
UP17_08515	COG1609	Transcriptional regulator
UP17_08520	COG1263	PTS System
UP17_08520	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_08525	COG1621	beta-fructofuranosidase activity
UP17_08530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_08535	COG2190	(PTS) system
UP17_08550	COG0662	Cupin 2, conserved barrel domain protein
UP17_08560	COG2323	membrane
UP17_08570	COG2801	Transposase and inactivated derivatives
UP17_08625	COG2801	Transposase and inactivated derivatives
UP17_08660	COG0277	FAD linked oxidase domain protein
UP17_08665	COG2801	Transposase and inactivated derivatives
UP17_08695	COG3848	Pyruvate phosphate dikinase
UP17_08695	COG0574	Belongs to the PEP-utilizing enzyme family
UP17_08730	COG1335	isochorismatase
UP17_08740	COG0346	lactoylglutathione lyase activity
UP17_08745	COG0346	lactoylglutathione lyase activity
UP17_08750	COG0400	carboxylic ester hydrolase activity
UP17_08755	COG2267	carboxylic ester hydrolase activity
UP17_08790	COG1114	Component of the transport system for branched-chain amino acids
UP17_08800	COG1595	DNA-templated transcription, initiation
UP17_08820	COG1733	regulation of RNA biosynthetic process
UP17_08825	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_08835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP17_08835	COG0456	acetyltransferase
UP17_08880	COG3764	Sortase (surface protein transpeptidase)
UP17_08905	COG2814	Major facilitator Superfamily
UP17_08915	COG0531	amino acid
UP17_08925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_08930	COG2188	Transcriptional regulator
UP17_08935	COG2318	DinB family
UP17_08975	COG2801	Transposase and inactivated derivatives
UP17_08990	COG0252	asparaginase activity
UP17_08995	COG1115	amino acid carrier protein
UP17_09000	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_09010	COG0861	Integral membrane protein TerC family
UP17_09015	COG1335	isochorismatase
UP17_09045	COG0697	spore germination
UP17_09055	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
UP17_09075	COG2329	Antibiotic biosynthesis monooxygenase
UP17_09100	COG0642	Histidine kinase
UP17_09105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UP17_09115	COG0789	Transcriptional regulator
UP17_09115	COG4978	Transcriptional regulator
UP17_09150	COG4989	oxidoreductase activity
UP17_09170	COG1288	antiporter activity
UP17_09175	COG1473	amidohydrolase
UP17_09195	COG1011	Hydrolase
UP17_09200	COG4335	DNA alkylation repair
UP17_09215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_09215	COG1263	PTS System
UP17_09220	COG0366	Alpha amylase catalytic
UP17_09225	COG2188	Transcriptional regulator
UP17_09230	COG2076	Multidrug Resistance protein
UP17_09235	COG2076	Multidrug Resistance protein
UP17_09290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
UP17_09300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
UP17_09305	COG4224	UPF0291 protein
UP17_09345	COG5577	PFAM Coat F domain
UP17_09360	COG3118	belongs to the thioredoxin family
UP17_09365	COG1902	pentaerythritol trinitrate reductase activity
UP17_09370	COG2259	Doxx family
UP17_09375	COG0785	Cytochrome C biogenesis protein
UP17_09385	COG4846	Membrane protein involved in cytochrome C biogenesis
UP17_09405	COG0419	ATPase involved in DNA repair
UP17_09410	COG0071	Belongs to the small heat shock protein (HSP20) family
UP17_09425	COG1012	belongs to the aldehyde dehydrogenase family
UP17_09430	COG0028	Belongs to the TPP enzyme family
UP17_09435	COG0069	glutamate synthase activity
UP17_09440	COG2066	Belongs to the glutaminase family
UP17_09460	COG0460	homoserine dehydrogenase
UP17_09465	COG1012	belongs to the aldehyde dehydrogenase family
UP17_09470	COG0833	amino acid
UP17_09490	COG0833	amino acid
UP17_09500	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_09510	COG4319	ketosteroid isomerase
UP17_09535	COG1937	Protein conserved in bacteria
UP17_09545	COG2210	Belongs to the sulfur carrier protein TusA family
UP17_09555	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_09560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_09560	COG0425	Belongs to the sulfur carrier protein TusA family
UP17_09570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_09570	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_09575	COG0425	Belongs to the sulfur carrier protein TusA family
UP17_09580	COG0730	response to heat
UP17_09630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_09640	COG4152	abc transporter atp-binding protein
UP17_09645	COG1668	transmembrane transport
UP17_09660	COG1937	Protein conserved in bacteria
UP17_09665	COG2608	mercury ion transmembrane transporter activity
UP17_09670	COG2217	Heavy metal translocating P-type atpase
UP17_09675	COG2318	DinB family
UP17_09685	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP17_09705	COG3540	Alkaline phosphatase
UP17_09710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_09715	COG0805	protein transport
UP17_09725	COG1113	amino acid transport
UP17_09745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_09750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP17_09760	COG2186	Transcriptional regulator
UP17_09775	COG2153	protein acetylation
UP17_09780	COG1846	Transcriptional regulator
UP17_09785	COG1132	(ABC) transporter
UP17_09795	COG1846	Transcriptional regulator
UP17_09800	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP17_09805	COG0022	dehydrogenase e1 component
UP17_09815	COG0346	lactoylglutathione lyase activity
UP17_09830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_09835	COG0697	spore germination
UP17_09845	COG2271	Major facilitator Superfamily
UP17_09850	COG0277	FAD linked oxidase domain protein
UP17_09855	COG1309	transcriptional regulator
UP17_09870	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
UP17_09880	COG2271	Major facilitator Superfamily
UP17_09895	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
UP17_09900	COG1914	H( )-stimulated, divalent metal cation uptake system
UP17_09905	COG4336	lyase activity
UP17_09910	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UP17_09915	COG1984	allophanate hydrolase subunit 2
UP17_09925	COG0243	molybdopterin cofactor binding
UP17_09955	COG2223	nitrite transmembrane transporter activity
UP17_09965	COG2197	response regulator
UP17_09975	COG4585	Histidine kinase
UP17_09980	COG1414	Transcriptional regulator
UP17_09995	COG1280	lysine exporter protein (LysE YggA)
UP17_10000	COG1378	Sugar-specific transcriptional regulator TrmB
UP17_10010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP17_10015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_10020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_10050	COG0405	Gamma-glutamyltransferase
UP17_10060	COG0010	Belongs to the arginase family
UP17_10065	COG0786	glutamate:sodium symporter activity
UP17_10070	COG2135	peptidase activity
UP17_10080	COG0561	phosphatase activity
UP17_10085	COG2271	Major facilitator Superfamily
UP17_10115	COG1846	Transcriptional regulator
UP17_10135	COG0583	DNA-binding transcription factor activity
UP17_10145	COG2801	Transposase and inactivated derivatives
UP17_10150	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_10160	COG2271	Major facilitator Superfamily
UP17_10175	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_10185	COG2271	Major facilitator Superfamily
UP17_10195	COG0583	DNA-binding transcription factor activity
UP17_10200	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_10210	COG0300	oxidoreductase activity
UP17_10215	COG1960	acyl-CoA dehydrogenase activity
UP17_10225	COG0439	Biotin carboxylase
UP17_10230	COG0511	ligase activity, forming carbon-carbon bonds
UP17_10235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP17_10240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_10245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_10245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_10265	COG1404	Belongs to the peptidase S8 family
UP17_10280	COG0697	spore germination
UP17_10320	COG1349	DNA-binding transcription factor activity
UP17_10325	COG0561	phosphatase activity
UP17_10330	COG2076	Multidrug Resistance protein
UP17_10335	COG2076	Multidrug Resistance protein
UP17_10365	COG1115	amino acid carrier protein
UP17_10375	COG1122	ATPase activity
UP17_10390	COG0310	cobalt ion transport
UP17_10465	COG1492	cobalamin metabolic process
UP17_10475	COG0515	serine threonine protein kinase
UP17_10485	COG2368	4-hydroxyphenylacetate
UP17_10535	COG2814	Major facilitator Superfamily
UP17_10550	COG1309	transcriptional regulator
UP17_10565	COG0300	oxidoreductase activity
UP17_10575	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UP17_10580	COG4721	ABC-type cobalt transport system, permease component
UP17_10595	COG0352	thiamine-phosphate diphosphorylase activity
UP17_10600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_10610	COG2022	thiamine diphosphate biosynthetic process
UP17_10615	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP17_10630	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
UP17_10635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_10650	COG0824	Thioesterase
UP17_10660	COG4841	protein insertion into membrane
UP17_10670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UP17_10675	COG1832	CoA-binding protein
UP17_10680	COG0187	DNA topoisomerase II activity
UP17_10685	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UP17_10690	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
UP17_10695	COG1737	Transcriptional regulator
UP17_10700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_10700	COG1263	PTS System
UP17_10715	COG3876	Protein conserved in bacteria
UP17_10720	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_10720	COG1263	PTS System
UP17_10730	COG0673	inositol 2-dehydrogenase activity
UP17_10765	COG3279	Response regulator of the LytR AlgR family
UP17_10775	COG3290	protein histidine kinase activity
UP17_10795	COG0738	Major facilitator superfamily
UP17_10820	COG2801	Transposase and inactivated derivatives
UP17_10840	COG0789	Transcriptional regulator
UP17_10845	COG2814	Major facilitator Superfamily
UP17_10855	COG3964	amidohydrolase
UP17_10900	COG1414	Transcriptional regulator
UP17_10915	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_10920	COG0028	Belongs to the TPP enzyme family
UP17_10930	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
UP17_10945	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_10955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_10990	COG1819	glycosyl
UP17_10995	COG2801	Transposase and inactivated derivatives
UP17_11030	COG0672	)-iron permease
UP17_11040	COG0583	DNA-binding transcription factor activity
UP17_11045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
UP17_11050	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP17_11075	COG1231	oxidoreductase activity
UP17_11085	COG1309	transcriptional regulator
UP17_11090	COG1960	acyl-CoA dehydrogenase activity
UP17_11095	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_11100	COG0439	Biotin carboxylase
UP17_11105	COG0511	ligase activity, forming carbon-carbon bonds
UP17_11110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP17_11115	COG1024	Enoyl-CoA hydratase
UP17_11120	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP17_11130	COG1335	isochorismatase
UP17_11135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
UP17_11140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UP17_11235	COG2801	Transposase and inactivated derivatives
UP17_11240	COG2851	Citrate transporter
UP17_11250	COG0583	DNA-binding transcription factor activity
UP17_11255	COG1053	succinate dehydrogenase
UP17_11260	COG2828	Protein conserved in bacteria
UP17_11265	COG0583	DNA-binding transcription factor activity
UP17_11270	COG2851	Citrate transporter
UP17_11285	COG0583	DNA-binding transcription factor activity
UP17_11325	COG3344	reverse transcriptase
UP17_11340	COG2801	Transposase and inactivated derivatives
UP17_11355	COG0456	acetyltransferase
UP17_11380	COG3344	reverse transcriptase
UP17_11410	COG3409	Peptidoglycan-binding domain 1 protein
UP17_11410	COG3773	Cell wall hydrolase
UP17_11440	COG1733	regulation of RNA biosynthetic process
UP17_11445	COG0778	Nitroreductase
UP17_11460	COG2318	DinB family
UP17_11480	COG1522	sequence-specific DNA binding
UP17_11560	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_11565	COG2814	Major facilitator Superfamily
UP17_11575	COG1742	UPF0060 membrane protein
UP17_11580	COG0697	spore germination
UP17_11650	COG2244	polysaccharide biosynthetic process
UP17_11660	COG0833	amino acid
UP17_11700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_11725	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_11740	COG1262	PFAM Formylglycine-generating sulfatase enzyme
UP17_11750	COG0741	lytic transglycosylase activity
UP17_11765	COG2318	DinB family
UP17_11785	COG0024	Methionine aminopeptidase
UP17_11790	COG2801	Transposase and inactivated derivatives
UP17_11810	COG2801	Transposase and inactivated derivatives
UP17_11820	COG1160	GTP binding
UP17_11825	COG1960	acyl-CoA dehydrogenase activity
UP17_11835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP17_11840	COG1473	amidohydrolase
UP17_11855	COG1113	amino acid transport
UP17_11865	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UP17_11875	COG0509	glycine decarboxylation via glycine cleavage system
UP17_11880	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP17_11885	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP17_11890	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UP17_11900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP17_11905	COG0788	formyltetrahydrofolate deformylase activity
UP17_11915	COG1760	l-serine dehydratase
UP17_11920	COG1760	l-serine dehydratase
UP17_11925	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP17_11930	COG0022	dehydrogenase e1 component
UP17_11935	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_11940	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP17_11945	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_11950	COG3284	Transcriptional regulator
UP17_11960	COG2720	vancomycin resistance protein
UP17_11970	COG0586	Pfam SNARE associated Golgi protein
UP17_11975	COG1183	phosphatidylcholine synthase activity
UP17_11980	COG0586	Pfam SNARE associated Golgi protein
UP17_11990	COG0697	spore germination
UP17_11995	COG1802	Transcriptional regulator
UP17_12000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
UP17_12030	COG2068	MobA-Related Protein
UP17_12035	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
UP17_12045	COG0247	lactate metabolic process
UP17_12050	COG0277	FAD linked oxidase domain protein
UP17_12060	COG1177	transmembrane transport
UP17_12065	COG1176	ABC-type spermidine putrescine transport system, permease component I
UP17_12075	COG1840	ABC-type Fe3 transport system, periplasmic component
UP17_12085	COG2204	response regulator
UP17_12090	COG3852	Histidine kinase
UP17_12095	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
UP17_12105	COG0640	Transcriptional regulator
UP17_12130	COG2223	nitrite transmembrane transporter activity
UP17_12135	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
UP17_12150	COG0668	transmembrane transport
UP17_12175	COG2610	gluconate transmembrane transporter activity
UP17_12180	COG1929	Belongs to the glycerate kinase type-1 family
UP17_12190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_12220	COG0579	oxidoreductase
UP17_12225	COG1802	Transcriptional regulator
UP17_12245	COG1309	transcriptional regulator
UP17_12250	COG0582	viral genome integration into host DNA
UP17_12255	COG4294	response to UV
UP17_12260	COG0626	cystathionine gamma-synthase activity
UP17_12280	COG1131	(ABC) transporter
UP17_12285	COG1725	Transcriptional regulator
UP17_12305	COG0542	response to heat
UP17_12310	COG1388	LysM domain
UP17_12310	COG0791	NLP P60 protein
UP17_12330	COG0583	DNA-binding transcription factor activity
UP17_12340	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UP17_12345	COG1174	glycine betaine transport
UP17_12350	COG1732	Glycine betaine
UP17_12355	COG1174	glycine betaine transport
UP17_12360	COG1125	glycine betaine transport
UP17_12360	COG0517	IMP dehydrogenase activity
UP17_12365	COG1960	acyl-CoA dehydrogenase activity
UP17_12390	COG5002	protein histidine kinase activity
UP17_12395	COG0745	RESPONSE REGULATOR receiver
UP17_12415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP17_12420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP17_12425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_12455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_12455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_12460	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_12495	COG1819	glycosyl
UP17_12525	COG4412	M6 family metalloprotease domain protein
UP17_12525	COG3291	Pkd domain containing protein
UP17_12560	COG2610	gluconate transmembrane transporter activity
UP17_12570	COG3829	transcription factor binding
UP17_12570	COG3290	protein histidine kinase activity
UP17_12585	COG2234	aminopeptidase activity
UP17_12615	COG0671	phosphoesterase, PA-phosphatase related
UP17_12665	COG2304	oxidoreductase activity
UP17_12685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_12720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
UP17_12725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_12750	COG2801	Transposase and inactivated derivatives
UP17_12815	COG2259	Doxx family
UP17_12820	COG0501	Belongs to the peptidase M48B family
UP17_12830	COG0702	epimerase
UP17_12835	COG0406	alpha-ribazole phosphatase activity
UP17_12855	COG0708	Exodeoxyribonuclease III
UP17_12860	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_12865	COG0297	glycogen (starch) synthase activity
UP17_12870	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UP17_12875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
UP17_12880	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
UP17_12900	COG3663	DNA glycosylase
UP17_12925	COG0730	response to heat
UP17_12950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
UP17_12955	COG0529	Catalyzes the synthesis of activated sulfate
UP17_12960	COG2046	Belongs to the sulfate adenylyltransferase family
UP17_12965	COG0175	sulfate reduction
UP17_12970	COG0431	NADPH-dependent FMN reductase
UP17_12985	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
UP17_12990	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
UP17_12995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_13010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP17_13015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
UP17_13025	COG1164	Oligoendopeptidase f
UP17_13035	COG3403	YqcI/YcgG family
UP17_13060	COG2197	response regulator
UP17_13070	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP17_13080	COG0628	permease
UP17_13090	COG1376	ErfK ybiS ycfS ynhG family protein
UP17_13115	COG0679	Auxin Efflux Carrier
UP17_13120	COG0590	tRNA wobble adenosine to inosine editing
UP17_13130	COG2706	6-phosphogluconolactonase activity
UP17_13145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_13150	COG1012	belongs to the aldehyde dehydrogenase family
UP17_13155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_13165	COG1278	Cold shock
UP17_13170	COG1024	Enoyl-CoA hydratase
UP17_13175	COG4608	Belongs to the ABC transporter superfamily
UP17_13180	COG0444	Belongs to the ABC transporter superfamily
UP17_13185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_13190	COG0601	transmembrane transport
UP17_13195	COG4166	transmembrane transport
UP17_13215	COG2340	Cysteine-rich secretory protein family
UP17_13225	COG2176	DNA-directed DNA polymerase activity
UP17_13230	COG1511	domain protein
UP17_13240	COG0561	phosphatase activity
UP17_13275	COG1012	belongs to the aldehyde dehydrogenase family
UP17_13280	COG0861	Integral membrane protein TerC family
UP17_13290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_13295	COG0604	alcohol dehydrogenase
UP17_13300	COG2046	Belongs to the sulfate adenylyltransferase family
UP17_13305	COG0529	Catalyzes the synthesis of activated sulfate
UP17_13310	COG0730	response to heat
UP17_13315	COG1216	Glycosyl transferase, family 2
UP17_13315	COG0463	Glycosyl transferase, family 2
UP17_13320	COG0438	transferase activity, transferring glycosyl groups
UP17_13350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UP17_13355	COG1086	Polysaccharide biosynthesis protein
UP17_13365	COG1132	(ABC) transporter
UP17_13380	COG1388	LysM domain
UP17_13380	COG3858	chitin binding
UP17_13385	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_13390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_13395	COG1937	Protein conserved in bacteria
UP17_13405	COG1027	Aspartate ammonia-lyase
UP17_13410	COG0252	asparaginase activity
UP17_13430	COG2040	homocysteine
UP17_13435	COG0833	amino acid
UP17_13440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
UP17_13445	COG0400	carboxylic ester hydrolase activity
UP17_13450	COG0346	lactoylglutathione lyase activity
UP17_13455	COG0346	lactoylglutathione lyase activity
UP17_13475	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_13480	COG1764	response to oxidative stress
UP17_13485	COG3344	reverse transcriptase
UP17_13510	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
UP17_13515	COG1733	regulation of RNA biosynthetic process
UP17_13530	COG1506	peptidase
UP17_13530	COG0823	Involved in the tonB-independent uptake of proteins
UP17_13530	COG4946	Tricorn protease homolog
UP17_13535	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
UP17_13540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_13545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP17_13550	COG1131	(ABC) transporter
UP17_13560	COG0385	Bile acid
UP17_13565	COG2814	Major facilitator Superfamily
UP17_13570	COG5002	protein histidine kinase activity
UP17_13575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_13590	COG0514	ATP-dependent DNA helicase (RecQ)
UP17_13595	COG1388	LysM domain
UP17_13595	COG3584	3D domain protein
UP17_13610	COG3546	catalase activity
UP17_13615	COG2996	Protein conserved in bacteria
UP17_13640	COG1247	-acetyltransferase
UP17_13645	COG3973	AAA domain
UP17_13655	COG1714	RDD family
UP17_13660	COG0488	(ABC) transporter
UP17_13675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_13685	COG1172	Belongs to the binding-protein-dependent transport system permease family
UP17_13695	COG1879	ABC-type sugar transport system periplasmic component
UP17_13700	COG1349	DNA-binding transcription factor activity
UP17_13705	COG1621	beta-fructofuranosidase activity
UP17_13710	COG1621	beta-fructofuranosidase activity
UP17_13715	COG2182	Extracellular solute-binding protein
UP17_13720	COG4753	response regulator
UP17_13720	COG2207	Transcriptional regulator
UP17_13725	COG2972	Histidine kinase
UP17_13740	COG2801	Transposase and inactivated derivatives
UP17_13750	COG0069	glutamate synthase activity
UP17_13765	COG2268	Band 7 protein
UP17_13815	COG2801	Transposase and inactivated derivatives
UP17_13840	COG0697	spore germination
UP17_13845	COG1012	belongs to the aldehyde dehydrogenase family
UP17_13860	COG1454	alcohol dehydrogenase
UP17_13865	COG1012	belongs to the aldehyde dehydrogenase family
UP17_13880	COG1063	alcohol dehydrogenase
UP17_13885	COG5577	PFAM Coat F domain
UP17_13920	COG2268	Band 7 protein
UP17_13925	COG1585	Membrane protein implicated in regulation of membrane protease activity
UP17_13930	COG1268	BioY protein
UP17_13940	COG1272	protein, Hemolysin III
UP17_13950	COG3773	Cell wall hydrolase
UP17_13960	COG0432	Pfam Uncharacterised protein family UPF0047
UP17_13970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP17_13970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
UP17_13970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_13975	COG1105	Belongs to the carbohydrate kinase PfkB family
UP17_13980	COG1349	DNA-binding transcription factor activity
UP17_13985	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_13990	COG0567	Dehydrogenase, E1 component
UP17_13995	COG3384	dioxygenase
UP17_14005	COG0646	methionine synthase
UP17_14005	COG1410	methionine synthase
UP17_14010	COG0646	methionine synthase
UP17_14010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UP17_14015	COG2258	MOSC domain
UP17_14020	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
UP17_14025	COG3285	dna ligase
UP17_14025	COG1793	dna ligase
UP17_14035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
UP17_14045	COG0288	reversible hydration of carbon dioxide
UP17_14075	COG1346	cytolysis
UP17_14085	COG0668	transmembrane transport
UP17_14090	COG0534	Mate efflux family protein
UP17_14095	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_14105	COG2340	Cysteine-rich secretory protein family
UP17_14115	COG5002	protein histidine kinase activity
UP17_14120	COG0745	RESPONSE REGULATOR receiver
UP17_14140	COG0523	cobalamin synthesis protein
UP17_14145	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
UP17_14150	COG0235	Class ii aldolase
UP17_14155	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
UP17_14160	COG1850	ribulose-bisphosphate carboxylase activity
UP17_14165	COG0436	Aminotransferase
UP17_14170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
UP17_14180	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
UP17_14185	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
UP17_14195	COG0793	Belongs to the peptidase S41A family
UP17_14195	COG3409	Peptidoglycan-binding domain 1 protein
UP17_14200	COG0813	purine-nucleoside phosphorylase activity
UP17_14215	COG4479	Belongs to the UPF0346 family
UP17_14225	COG1509	lysine 2,3-aminomutase activity
UP17_14230	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
UP17_14235	COG1845	cytochrome c oxidase, subunit III
UP17_14260	COG1509	lysine 2,3-aminomutase activity
UP17_14265	COG3829	transcription factor binding
UP17_14270	COG0456	acetyltransferase
UP17_14275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_14280	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP17_14285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP17_14290	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_14300	COG1619	proteins homologs of microcin C7 resistance protein MccF
UP17_14310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_14330	COG2755	lipolytic protein G-D-S-L family
UP17_14335	COG1999	signal sequence binding
UP17_14340	COG1307	EDD domain protein, DegV family
UP17_14350	COG0805	protein transport
UP17_14355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UP17_14360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UP17_14365	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP17_14390	COG0861	Integral membrane protein TerC family
UP17_14400	COG0405	Gamma-glutamyltransferase
UP17_14405	COG2521	methyltransferase
UP17_14405	COG2136	Putative SAM-dependent methyltransferase
UP17_14415	COG0129	dihydroxy-acid dehydratase activity
UP17_14420	COG1413	lyase activity
UP17_14425	COG0488	(ABC) transporter
UP17_14430	COG1418	mRNA catabolic process
UP17_14435	COG1307	EDD domain protein, DegV family
UP17_14440	COG0386	Belongs to the glutathione peroxidase family
UP17_14450	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
UP17_14465	COG1321	iron dependent repressor
UP17_14475	COG1396	sequence-specific DNA binding
UP17_14480	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
UP17_14490	COG1620	l-lactate permease
UP17_14500	COG2205	protein histidine kinase activity
UP17_14510	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
UP17_14515	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UP17_14525	COG5609	conserved protein (DUF2294)
UP17_14535	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP17_14565	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_14580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_14620	COG0569	domain protein
UP17_14625	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP17_14635	COG2814	Major facilitator Superfamily
UP17_14640	COG4565	transcriptional regulatory protein
UP17_14645	COG3290	protein histidine kinase activity
UP17_14655	COG3493	citrate carrier protein
UP17_14685	COG2814	Major facilitator Superfamily
UP17_14720	COG0640	Transcriptional regulator
UP17_14740	COG0702	epimerase
UP17_14745	COG1737	Transcriptional regulator
UP17_14750	COG2971	BadF BadG BcrA BcrD
UP17_14760	COG1447	Phosphotransferase system cellobiose-specific component IIA
UP17_14775	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
UP17_14805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
UP17_14845	COG0833	amino acid
UP17_14850	COG1834	amidinotransferase
UP17_14860	COG1288	antiporter activity
UP17_14865	COG4187	Peptidase family M20/M25/M40
UP17_14870	COG2235	arginine
UP17_14895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_14900	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
UP17_14905	COG3716	PTS system mannose fructose sorbose family IID component
UP17_14910	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_14920	COG1737	Transcriptional regulator
UP17_14930	COG0531	amino acid
UP17_14970	COG1511	domain protein
UP17_14990	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UP17_14995	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
UP17_15005	COG1959	2 iron, 2 sulfur cluster binding
UP17_15020	COG0328	RNA-DNA hybrid ribonuclease activity
UP17_15025	COG0328	RNA-DNA hybrid ribonuclease activity
UP17_15040	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP17_15055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP17_15060	COG1755	Isoprenylcysteine carboxyl methyltransferase
UP17_15065	COG3424	synthase
UP17_15070	COG2233	PERMEase
UP17_15080	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
UP17_15085	COG1199	ATP-dependent helicase activity
UP17_15090	COG1278	Cold shock
UP17_15095	COG0116	Belongs to the methyltransferase superfamily
UP17_15100	COG3599	regulation of cell shape
UP17_15110	COG3359	exonuclease
UP17_15115	COG1205	dead DEAH box helicase
UP17_15115	COG1111	helicase
UP17_15165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UP17_15170	COG3935	DnaD domain protein
UP17_15175	COG0017	Asparaginyl-tRNA synthetase
UP17_15180	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_15200	COG0583	DNA-binding transcription factor activity
UP17_15205	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_15230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP17_15240	COG0436	Aminotransferase
UP17_15250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
UP17_15250	COG1199	ATP-dependent helicase activity
UP17_15255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
UP17_15265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
UP17_15275	COG0617	tRNA 3'-terminal CCA addition
UP17_15280	COG0438	transferase activity, transferring glycosyl groups
UP17_15285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP17_15290	COG1803	Methylglyoxal synthase
UP17_15300	COG1694	Mazg nucleotide pyrophosphohydrolase
UP17_15305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
UP17_15315	COG2738	Putative neutral zinc metallopeptidase
UP17_15325	COG4347	Protein of unknown function (DUF1405)
UP17_15330	COG2010	Cytochrome c
UP17_15330	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UP17_15350	COG5582	Belongs to the UPF0302 family
UP17_15355	COG0457	Tetratricopeptide repeat
UP17_15360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
UP17_15365	COG0287	Prephenate dehydrogenase
UP17_15370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP17_15375	COG4401	Chorismate mutase type I
UP17_15380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
UP17_15385	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UP17_15390	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UP17_15395	COG0105	UTP biosynthetic process
UP17_15400	COG0142	geranyltranstransferase activity
UP17_15405	COG2226	methyltransferase
UP17_15420	COG0302	gtp cyclohydrolase
UP17_15425	COG0776	regulation of translation
UP17_15430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
UP17_15455	COG3290	protein histidine kinase activity
UP17_15455	COG3829	transcription factor binding
UP17_15470	COG0531	amino acid
UP17_15475	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
UP17_15495	COG0539	negative regulation of cytoplasmic translation
UP17_15505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
UP17_15515	COG2959	enzyme of heme biosynthesis
UP17_15520	COG3409	Peptidoglycan-binding domain 1 protein
UP17_15520	COG3773	Cell wall hydrolase
UP17_15525	COG2339	peptidase activity
UP17_15535	COG0492	ferredoxin-NADP+ reductase activity
UP17_15540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_15545	COG4862	establishment of competence for transformation
UP17_15570	COG1266	CAAX protease self-immunity
UP17_15575	COG0514	ATP-dependent DNA helicase (RecQ)
UP17_15580	COG4955	Helix-turn-helix domain
UP17_15590	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
UP17_15600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UP17_15610	COG1595	DNA-templated transcription, initiation
UP17_15615	COG5002	protein histidine kinase activity
UP17_15620	COG0745	RESPONSE REGULATOR receiver
UP17_15625	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP17_15630	COG1333	cytochrome c biogenesis protein
UP17_15635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_15640	COG1187	pseudouridine synthase activity
UP17_15645	COG0700	Nucleoside recognition
UP17_15650	COG2715	membrane protein required for spore maturation
UP17_15655	COG1686	Belongs to the peptidase S11 family
UP17_15665	COG0450	alkyl hydroperoxide reductase
UP17_15670	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UP17_15685	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
UP17_15695	COG1547	Domain of unknown function (DUF309)
UP17_15705	COG4086	secreted protein
UP17_15715	COG0697	spore germination
UP17_15735	COG2252	PERMEase
UP17_15745	COG2172	sigma factor antagonist activity
UP17_15755	COG1686	Belongs to the peptidase S11 family
UP17_15775	COG4974	Belongs to the 'phage' integrase family
UP17_15785	COG0735	belongs to the Fur family
UP17_15790	COG1300	Membrane
UP17_15800	COG1379	DNA repair
UP17_15810	COG0667	Aldo Keto reductase
UP17_15815	COG1764	response to oxidative stress
UP17_15820	COG1846	Transcriptional regulator
UP17_15830	COG1073	alpha beta
UP17_15835	COG4918	Iron-sulphur cluster biosynthesis
UP17_15845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP17_15850	COG0791	NLP P60 protein
UP17_15850	COG1388	LysM domain
UP17_15860	COG0300	oxidoreductase activity
UP17_15865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_15870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_15910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
UP17_15920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
UP17_15925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
UP17_15930	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP17_15935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
UP17_15940	COG0346	lactoylglutathione lyase activity
UP17_15945	COG1376	ErfK ybiS ycfS ynhG family protein
UP17_15950	COG4129	membrane
UP17_15955	COG1126	abc transporter atp-binding protein
UP17_15960	COG0765	amino acid transport
UP17_15965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP17_15980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_15980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_15985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_15995	COG0508	dehydrogenase complex catalyzes the overall conversion of
UP17_16000	COG0022	dehydrogenase e1 component
UP17_16005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
UP17_16010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
UP17_16035	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_16045	COG0745	RESPONSE REGULATOR receiver
UP17_16050	COG0750	zinc metalloprotease
UP17_16055	COG0497	DNA recombination
UP17_16060	COG1438	arginine binding
UP17_16065	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
UP17_16070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UP17_16080	COG1722	exodeoxyribonuclease VII activity
UP17_16085	COG1570	exodeoxyribonuclease VII activity
UP17_16095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UP17_16100	COG1302	Protein conserved in bacteria
UP17_16105	COG0439	Biotin carboxylase
UP17_16110	COG0511	ligase activity, forming carbon-carbon bonds
UP17_16150	COG3854	ATPases associated with a variety of cellular activities
UP17_16155	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UP17_16160	COG0006	proline dipeptidase activity
UP17_16175	COG3872	metal-dependent enzyme
UP17_16185	COG1752	Esterase of the alpha-beta hydrolase superfamily
UP17_16200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UP17_16205	COG0095	Lipoate-protein ligase
UP17_16210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_16220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
UP17_16230	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP17_16265	COG4537	Required for transformation and DNA binding
UP17_16270	COG1459	type II secretion system
UP17_16405	COG1393	Belongs to the ArsC family
UP17_16425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_16450	COG1368	sulfuric ester hydrolase activity
UP17_16455	COG1940	carbohydrate kinase activity
UP17_16470	COG0457	Tetratricopeptide repeat
UP17_16470	COG0705	Rhomboid family
UP17_16480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
UP17_16505	COG0704	Plays a role in the regulation of phosphate uptake
UP17_16515	COG0581	inorganic phosphate transmembrane transporter activity
UP17_16520	COG0573	inorganic phosphate transmembrane transporter activity
UP17_16525	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UP17_16535	COG0477	Major facilitator Superfamily
UP17_16545	COG2839	Protein conserved in bacteria
UP17_16550	COG5521	maltodextrose utilization protein MalA
UP17_16560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UP17_16565	COG4709	membrane
UP17_16570	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
UP17_16575	COG0735	belongs to the Fur family
UP17_16580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UP17_16585	COG1121	(ABC) transporter
UP17_16595	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
UP17_16600	COG0513	Belongs to the DEAD box helicase family
UP17_16615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UP17_16620	COG2384	SAM-dependent methyltransferase
UP17_16625	COG2010	Cytochrome c
UP17_16635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UP17_16640	COG0358	DNA primase activity
UP17_16645	COG1671	Belongs to the UPF0178 family
UP17_16650	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
UP17_16655	COG0517	IMP dehydrogenase activity
UP17_16660	COG0751	glycine-tRNA ligase activity
UP17_16665	COG0752	glycyl-tRNA synthetase alpha subunit
UP17_16670	COG1381	Involved in DNA repair and RecF pathway recombination
UP17_16675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UP17_16680	COG0295	cytidine deaminase activity
UP17_16685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UP17_16695	COG1480	7TM receptor with intracellular HD hydrolase
UP17_16700	COG1702	phosphate starvation-inducible protein PhoH
UP17_16720	COG4864	UPF0365 protein
UP17_16725	COG1030	water channel activity
UP17_16730	COG1610	YqeY-like protein
UP17_16735	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UP17_16740	COG1283	sodium-dependent phosphate transmembrane transporter activity
UP17_16745	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
UP17_16750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP17_16755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UP17_16760	COG2264	protein methyltransferase activity
UP17_16770	COG0443	Heat shock 70 kDa protein
UP17_16775	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
UP17_16785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UP17_16800	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP17_16810	COG0268	Binds directly to 16S ribosomal RNA
UP17_16815	COG1466	dna polymerase III delta subunit
UP17_16825	COG0658	competence protein
UP17_16825	COG2333	competence protein COMEC
UP17_16830	COG2131	deaminase
UP17_16835	COG1596	polysaccharide export
UP17_16835	COG1555	photosystem II stabilization
UP17_16840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UP17_16845	COG2226	methyltransferase
UP17_16850	COG0799	negative regulation of ribosome biogenesis
UP17_16855	COG1713	HD superfamily hydrolase involved in NAD metabolism
UP17_16860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
UP17_16865	COG1534	Rna-binding protein
UP17_16875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
UP17_16880	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
UP17_16885	COG0688	phosphatidylethanolamine metabolic process
UP17_16890	COG1183	phosphatidylcholine synthase activity
UP17_16915	COG0626	cystathionine gamma-synthase activity
UP17_16920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UP17_16930	COG2226	methyltransferase
UP17_16945	COG0768	penicillin binding
UP17_16950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UP17_16970	COG0572	uridine kinase
UP17_16995	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
UP17_17000	COG3906	Belongs to the UPF0473 family
UP17_17005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
UP17_17020	COG0628	permease
UP17_17030	COG3881	PFAM PRC-barrel domain
UP17_17035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
UP17_17040	COG1704	LemA family
UP17_17045	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UP17_17055	COG0482	sulfurtransferase activity
UP17_17060	COG1104	cysteine desulfurase activity
UP17_17065	COG1959	2 iron, 2 sulfur cluster binding
UP17_17075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UP17_17090	COG1131	(ABC) transporter
UP17_17095	COG1725	Transcriptional regulator
UP17_17105	COG1316	TRANSCRIPTIONal
UP17_17120	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UP17_17125	COG1132	(ABC) transporter
UP17_17200	COG0438	transferase activity, transferring glycosyl groups
UP17_17210	COG0438	transferase activity, transferring glycosyl groups
UP17_17215	COG0438	transferase activity, transferring glycosyl groups
UP17_17225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UP17_17230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_17245	COG4464	protein tyrosine phosphatase activity
UP17_17250	COG0489	protein tyrosine kinase activity
UP17_17280	COG2814	Major facilitator Superfamily
UP17_17300	COG0411	ABC transporter
UP17_17310	COG0559	Belongs to the binding-protein-dependent transport system permease family
UP17_17330	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
UP17_17345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
UP17_17350	COG0124	histidyl-tRNA synthetase
UP17_17360	COG0860	N-Acetylmuramoyl-L-alanine amidase
UP17_17360	COG3103	Sh3 type 3 domain protein
UP17_17360	COG4991	sh3 domain protein
UP17_17365	COG1490	D-aminoacyl-tRNA deacylase activity
UP17_17370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UP17_17375	COG2801	Transposase and inactivated derivatives
UP17_17385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
UP17_17390	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
UP17_17390	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
UP17_17395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP17_17395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UP17_17405	COG2244	polysaccharide biosynthetic process
UP17_17410	COG2323	membrane
UP17_17420	COG1862	Preprotein translocase
UP17_17430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UP17_17475	COG0157	Belongs to the NadC ModD family
UP17_17480	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
UP17_17485	COG1104	cysteine desulfurase activity
UP17_17490	COG1827	regulation of RNA biosynthetic process
UP17_17495	COG0077	Prephenate dehydratase
UP17_17500	COG4492	Belongs to the UPF0735 family
UP17_17505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
UP17_17510	COG3290	protein histidine kinase activity
UP17_17520	COG2868	ribosomal protein
UP17_17525	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UP17_17530	COG1530	ribonuclease E activity
UP17_17535	COG1994	Peptidase M50
UP17_17540	COG0739	heme binding
UP17_17550	COG1098	S1 RNA binding domain
UP17_17555	COG2894	cell division
UP17_17570	COG1792	Involved in formation and maintenance of cell shape
UP17_17580	COG1077	Cell shape determining protein MreB Mrl
UP17_17585	COG2003	Belongs to the UPF0758 family
UP17_17600	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
UP17_17610	COG0285	dihydrofolate synthase activity
UP17_17620	COG0189	ligase activity
UP17_17625	COG0525	valine-tRNA ligase activity
UP17_17635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP17_17645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
UP17_17650	COG0113	porphobilinogen synthase activity
UP17_17660	COG0181	hydroxymethylbilane synthase activity
UP17_17665	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UP17_17680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UP17_17685	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UP17_17690	COG0470	DNA polymerase III
UP17_17690	COG1067	ATP-dependent peptidase activity
UP17_17700	COG0544	peptidyl-prolyl cis-trans isomerase activity
UP17_17710	COG0066	3-isopropylmalate dehydratase activity
UP17_17715	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UP17_17725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UP17_17730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UP17_17735	COG0440	acetolactate synthase activity
UP17_17740	COG0028	Belongs to the TPP enzyme family
UP17_17805	COG0622	Phosphoesterase
UP17_17810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
UP17_17830	COG5401	PFAM Sporulation and spore germination
UP17_17840	COG1846	Transcriptional regulator
UP17_17845	COG2197	response regulator
UP17_17850	COG0824	Thioesterase
UP17_17855	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UP17_17860	COG1053	succinate dehydrogenase
UP17_17865	COG2009	succinate dehydrogenase
UP17_17870	COG1719	4-vinyl reductase, 4VR
UP17_17885	COG3118	belongs to the thioredoxin family
UP17_17890	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
UP17_17895	COG2086	electron transfer activity
UP17_17900	COG1024	Enoyl-CoA hydratase
UP17_17905	COG1309	transcriptional regulator
UP17_17910	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_17920	COG3766	membrane
UP17_17930	COG1796	DNA polymerase
UP17_17930	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP17_17935	COG1286	toxin biosynthetic process
UP17_17940	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
UP17_17945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UP17_17950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UP17_17950	COG0072	phenylalanine-tRNA ligase activity
UP17_17955	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UP17_17960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UP17_17980	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
UP17_17985	COG0247	lactate metabolic process
UP17_17990	COG0277	FAD linked oxidase domain protein
UP17_17995	COG3835	regulator
UP17_18000	COG1620	l-lactate permease
UP17_18005	COG2186	Transcriptional regulator
UP17_18010	COG0247	lactate metabolic process
UP17_18015	COG1139	Iron-sulfur cluster binding protein
UP17_18020	COG1556	Lactate utilization protein
UP17_18025	COG1363	Peptidase, m42
UP17_18045	COG3326	Membrane
UP17_18050	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UP17_18060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UP17_18065	COG1247	-acetyltransferase
UP17_18070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP17_18080	COG1484	DNA-dependent DNA replication
UP17_18085	COG3611	Membrane attachment protein
UP17_18090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
UP17_18095	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
UP17_18105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP17_18110	COG0237	dephospho-CoA kinase activity
UP17_18115	COG1971	Probably functions as a manganese efflux pump
UP17_18120	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
UP17_18125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP17_18125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
UP17_18130	COG0330	HflC and HflK could
UP17_18140	COG5002	protein histidine kinase activity
UP17_18145	COG0745	RESPONSE REGULATOR receiver
UP17_18155	COG0538	isocitrate dehydrogenase activity
UP17_18160	COG0372	Belongs to the citrate synthase family
UP17_18165	COG2707	UPF0756 membrane protein
UP17_18170	COG0628	permease
UP17_18175	COG2224	Isocitrate lyase
UP17_18180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
UP17_18195	COG0205	6-phosphofructokinase activity
UP17_18200	COG0825	malonyl-CoA metabolic process
UP17_18205	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UP17_18210	COG2186	Transcriptional regulator
UP17_18215	COG0281	malic enzyme
UP17_18220	COG0587	DNA-directed DNA polymerase activity
UP17_18235	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
UP17_18245	COG4109	DRTGG domain
UP17_18255	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP17_18260	COG0006	proline dipeptidase activity
UP17_18270	COG0589	response to stress
UP17_18275	COG0165	Argininosuccinate lyase
UP17_18280	COG0137	argininosuccinate synthase activity
UP17_18290	COG0521	Mo-molybdopterin cofactor biosynthetic process
UP17_18300	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
UP17_18305	COG0827	DNA restriction-modification system
UP17_18310	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UP17_18315	COG3874	Sporulation protein YtfJ
UP17_18325	COG1714	RDD family
UP17_18330	COG0616	signal peptide processing
UP17_18335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
UP17_18340	COG0084	hydrolase, TatD family'
UP17_18350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP17_18360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP17_18375	COG2962	Rard protein
UP17_18380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
UP17_18385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP17_18395	COG0301	tRNA thio-modification
UP17_18400	COG1104	cysteine desulfurase activity
UP17_18405	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
UP17_18410	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
UP17_18415	COG1309	transcriptional regulator
UP17_18420	COG1956	GAF domain-containing protein
UP17_18425	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UP17_18430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UP17_18440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
UP17_18445	COG0454	-acetyltransferase
UP17_18450	COG0517	IMP dehydrogenase activity
UP17_18455	COG0123	including yeast histone deacetylase and acetoin utilization protein
UP17_18460	COG1609	Transcriptional regulator
UP17_18465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
UP17_18465	COG1605	Chorismate mutase
UP17_18470	COG3118	belongs to the thioredoxin family
UP17_18475	COG4980	gas vesicle protein
UP17_18485	COG2309	aminopeptidase activity
UP17_18505	COG4848	Belongs to the UPF0354 family
UP17_18510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_18525	COG3708	Transcriptional regulator
UP17_18525	COG2207	Transcriptional regulator
UP17_18530	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
UP17_18535	COG1363	Peptidase, m42
UP17_18545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_18550	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UP17_18560	COG0510	thiamine kinase activity
UP17_18580	COG1914	H( )-stimulated, divalent metal cation uptake system
UP17_18590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
UP17_18595	COG0534	Mate efflux family protein
UP17_18600	COG0586	Pfam SNARE associated Golgi protein
UP17_18615	COG3344	reverse transcriptase
UP17_18625	COG3344	reverse transcriptase
UP17_18630	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
UP17_18630	COG1587	Uroporphyrinogen-III synthase
UP17_18635	COG1587	Uroporphyrinogen-III synthase
UP17_18650	COG0039	L-malate dehydrogenase activity
UP17_18655	COG1620	l-lactate permease
UP17_18660	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP17_18670	COG2814	Major facilitator Superfamily
UP17_18680	COG4221	oxidoreductase activity
UP17_18690	COG1309	transcriptional regulator
UP17_18700	COG0701	Predicted permease
UP17_18730	COG2824	Alkylphosphonate utilization operon protein PhnA
UP17_18735	COG0745	RESPONSE REGULATOR receiver
UP17_18740	COG2205	protein histidine kinase activity
UP17_18745	COG1136	(ABC) transporter
UP17_18750	COG0577	efflux transmembrane transporter activity
UP17_18765	COG1349	DNA-binding transcription factor activity
UP17_18770	COG1187	pseudouridine synthase activity
UP17_18775	COG2244	polysaccharide biosynthetic process
UP17_18780	COG2081	HI0933 family
UP17_18795	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_18805	COG0473	3-isopropylmalate dehydrogenase activity
UP17_18815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UP17_18820	COG1902	pentaerythritol trinitrate reductase activity
UP17_18830	COG0656	L-ascorbic acid biosynthetic process
UP17_18835	COG2814	Major facilitator Superfamily
UP17_18840	COG1733	regulation of RNA biosynthetic process
UP17_18855	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UP17_18870	COG1647	Serine aminopeptidase, S33
UP17_18875	COG1695	Transcriptional regulator
UP17_18900	COG1309	transcriptional regulator
UP17_18915	COG0720	synthase
UP17_18925	COG0840	transmembrane signaling receptor activity
UP17_18955	COG4195	phage-related replication protein
UP17_18960	COG0791	NLP P60 protein
UP17_18960	COG1388	LysM domain
UP17_18975	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UP17_18995	COG0456	acetyltransferase
UP17_19000	COG2002	toxin-antitoxin pair type II binding
UP17_19005	COG0697	spore germination
UP17_19015	COG2076	Multidrug Resistance protein
UP17_19020	COG2076	Multidrug Resistance protein
UP17_19025	COG3739	integral membrane protein
UP17_19030	COG3655	Transcriptional regulator
UP17_19040	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP17_19050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UP17_19060	COG0697	spore germination
UP17_19065	COG0586	Pfam SNARE associated Golgi protein
UP17_19070	COG0671	phosphoesterase, PA-phosphatase related
UP17_19105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_19110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UP17_19115	COG1012	belongs to the aldehyde dehydrogenase family
UP17_19120	COG3829	transcription factor binding
UP17_19125	COG2801	Transposase and inactivated derivatives
UP17_19140	COG2514	catechol 2,3-dioxygenase activity
UP17_19145	COG2259	Doxx family
UP17_19155	COG0246	Mannitol dehydrogenase
UP17_19160	COG3711	transcriptional antiterminator
UP17_19165	COG2213	PTS system mannitol-specific
UP17_19165	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_19170	COG2851	Citrate transporter
UP17_19175	COG2207	Transcriptional regulator
UP17_19180	COG4565	transcriptional regulatory protein
UP17_19185	COG3290	protein histidine kinase activity
UP17_19195	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
UP17_19200	COG2169	Transcriptional regulator
UP17_19205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UP17_19220	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
UP17_19230	COG3142	Participates in the control of copper homeostasis
UP17_19245	COG0789	Transcriptional regulator
UP17_19260	COG1357	PFAM Pentapeptide repeats (8 copies)
UP17_19285	COG1823	symporter activity
UP17_19310	COG1113	amino acid transport
UP17_19345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UP17_19350	COG0477	Major facilitator Superfamily
UP17_19370	COG2197	response regulator
UP17_19375	COG4585	Histidine kinase
UP17_19400	COG3844	kynureninase activity
UP17_19410	COG3483	tryptophan 2,3-dioxygenase activity
UP17_19415	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
UP17_19420	COG1280	lysine exporter protein (LysE YggA)
UP17_19435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_19450	COG0778	Nitroreductase
UP17_19455	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UP17_19460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
UP17_19505	COG2801	Transposase and inactivated derivatives
UP17_19515	COG2721	sulfolactate sulfo-lyase activity
UP17_19520	COG1012	belongs to the aldehyde dehydrogenase family
UP17_19525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UP17_19530	COG2271	Major facilitator Superfamily
UP17_19540	COG2186	Transcriptional regulator
UP17_19545	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_19560	COG0583	DNA-binding transcription factor activity
UP17_19565	COG1511	domain protein
UP17_19570	COG2814	Major facilitator Superfamily
UP17_19575	COG1309	transcriptional regulator
UP17_19580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UP17_19585	COG1113	amino acid transport
UP17_19595	COG2814	Major facilitator Superfamily
UP17_19605	COG1280	lysine exporter protein (LysE YggA)
UP17_19610	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
UP17_19630	COG0833	amino acid
UP17_19640	COG0183	Belongs to the thiolase family
UP17_19645	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP17_19650	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP17_19655	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_19660	COG1141	Ferredoxin
UP17_19680	COG3829	transcription factor binding
UP17_19695	COG1609	Transcriptional regulator
UP17_19700	COG0561	phosphatase activity
UP17_19715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
UP17_19720	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
UP17_19725	COG2610	gluconate transmembrane transporter activity
UP17_19730	COG3290	protein histidine kinase activity
UP17_19730	COG3829	transcription factor binding
UP17_19740	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_19745	COG1028	Short-chain dehydrogenase reductase Sdr
UP17_19760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UP17_19765	COG1846	Transcriptional regulator
UP17_19780	COG0024	Methionine aminopeptidase
UP17_19785	COG2315	Protein conserved in bacteria
UP17_19815	COG3344	reverse transcriptase
UP17_19825	COG1876	peptidase activity
UP17_19840	COG3011	Protein conserved in bacteria
UP17_19845	COG0179	Fumarylacetoacetate (FAA) hydrolase
UP17_19900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
UP17_19915	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UP17_19945	COG2031	fatty acid transporter
UP17_19965	COG1687	branched-chain amino acid
UP17_19970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
UP17_19975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_19980	COG1476	TRANSCRIPTIONal
UP17_20100	COG5444	nuclease activity
UP17_20110	COG2205	protein histidine kinase activity
UP17_20135	COG0784	Response regulator, receiver
UP17_20140	COG4191	Histidine kinase
UP17_20155	COG3973	AAA domain
UP17_20180	COG1966	Carbon starvation protein
UP17_20185	COG3279	Response regulator of the LytR AlgR family
UP17_20190	COG3275	phosphorelay sensor kinase activity
UP17_20245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UP17_20255	COG0346	lactoylglutathione lyase activity
UP17_20270	COG2190	(PTS) system
UP17_20285	COG2602	Beta-lactamase
UP17_20295	COG0659	secondary active sulfate transmembrane transporter activity
UP17_20300	COG0288	reversible hydration of carbon dioxide
UP17_20310	COG5002	protein histidine kinase activity
UP17_20310	COG3850	Histidine kinase
UP17_20315	COG0745	RESPONSE REGULATOR receiver
UP17_20320	COG0697	spore germination
UP17_20330	COG1051	belongs to the nudix hydrolase family
UP17_20345	COG1694	Mazg nucleotide pyrophosphohydrolase
UP17_20365	COG0412	Dienelactone hydrolase
UP17_20385	COG1464	Belongs to the NlpA lipoprotein family
UP17_20390	COG2011	ABC-type metal ion transport system permease component
UP17_20395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UP17_20435	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_20460	COG0561	phosphatase activity
UP17_20480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_20500	COG0477	Major facilitator Superfamily
UP17_20505	COG1309	transcriptional regulator
UP17_20515	COG0583	DNA-binding transcription factor activity
UP17_20520	COG0697	spore germination
UP17_20525	COG1193	negative regulation of DNA recombination
UP17_20530	COG3842	ATPase activity
UP17_20540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
UP17_20540	COG1263	PTS System
UP17_20540	COG2190	(PTS) system
UP17_20545	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
UP17_20570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_20595	COG2233	PERMEase
UP17_20600	COG0402	S-adenosylhomocysteine deaminase activity
UP17_20605	COG0402	S-adenosylhomocysteine deaminase activity
UP17_20610	COG0402	S-adenosylhomocysteine deaminase activity
UP17_20615	COG0747	negative chemotaxis
UP17_20630	COG0747	negative chemotaxis
UP17_20645	COG0444	Belongs to the ABC transporter superfamily
UP17_20650	COG4608	Belongs to the ABC transporter superfamily
UP17_20655	COG2972	Histidine kinase
UP17_20660	COG2207	Transcriptional regulator
UP17_20670	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP17_20680	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
UP17_20740	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_20745	COG1522	sequence-specific DNA binding
UP17_20775	COG1252	NADH dehydrogenase
UP17_20785	COG0018	arginyl-trna synthetase
UP17_20790	COG2197	response regulator
UP17_20795	COG3239	Fatty acid desaturase
UP17_20800	COG3858	chitin binding
UP17_20805	COG0697	spore germination
UP17_20810	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
UP17_20825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
UP17_20830	COG1131	(ABC) transporter
UP17_20845	COG3583	domain protein
UP17_20845	COG3584	3D domain protein
UP17_20850	COG1247	-acetyltransferase
UP17_20860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP17_20900	COG1301	dicarboxylic acid transport
UP17_20930	COG0583	DNA-binding transcription factor activity
UP17_20940	COG3773	Cell wall hydrolase
UP17_20945	COG3344	reverse transcriptase
UP17_20950	COG1522	sequence-specific DNA binding
UP17_20975	COG2801	Transposase and inactivated derivatives
UP17_20995	COG1522	sequence-specific DNA binding
UP17_21000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
UP17_21005	COG2814	Major facilitator Superfamily
UP17_21020	COG3773	Cell wall hydrolase
UP17_21020	COG3409	Peptidoglycan-binding domain 1 protein
UP17_21045	COG0402	S-adenosylhomocysteine deaminase activity
UP17_21055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
UP17_21065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_21125	COG0822	iron-sulfur transferase activity
UP17_21135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UP17_21140	COG2072	flavoprotein involved in K transport
UP17_21145	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_21165	COG3344	reverse transcriptase
UP17_21185	COG1595	DNA-templated transcription, initiation
UP17_21205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_21210	COG0346	lactoylglutathione lyase activity
UP17_21235	COG1511	domain protein
UP17_21250	COG3655	Transcriptional regulator
UP17_21270	COG1464	Belongs to the NlpA lipoprotein family
UP17_21300	COG0671	phosphoesterase, PA-phosphatase related
UP17_21310	COG0024	Methionine aminopeptidase
UP17_21315	COG2318	DinB family
UP17_21385	COG0384	phenazine biosynthesis protein PhzF
UP17_21420	COG1114	Component of the transport system for branched-chain amino acids
UP17_21430	COG1760	l-serine dehydratase
UP17_21435	COG1760	l-serine dehydratase
UP17_21455	COG0737	Belongs to the 5'-nucleotidase family
UP17_21460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_21465	COG0697	spore germination
UP17_21470	COG0384	phenazine biosynthesis protein PhzF
UP17_21480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_21490	COG2188	Transcriptional regulator
UP17_21505	COG1131	(ABC) transporter
UP17_21510	COG1309	transcriptional regulator
UP17_21525	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UP17_21530	COG0569	domain protein
UP17_21540	COG1366	Belongs to the anti-sigma-factor antagonist family
UP17_21545	COG0500	methyltransferase
UP17_21545	COG3615	Tellurite resistance protein tehB
UP17_21550	COG2226	methyltransferase
UP17_21555	COG2226	methyltransferase
UP17_21575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UP17_21580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
UP17_21585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UP17_21590	COG2910	NAD(P)H-binding
UP17_21595	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
UP17_21605	COG1959	2 iron, 2 sulfur cluster binding
UP17_21610	COG4193	domain, Protein
UP17_21615	COG2112	serine threonine protein kinase
UP17_21625	COG3832	glyoxalase III activity
UP17_21630	COG0640	Transcriptional regulator
UP17_21635	COG1511	domain protein
UP17_21640	COG1959	2 iron, 2 sulfur cluster binding
UP17_21645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_21660	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
UP17_21665	COG4122	O-methyltransferase activity
UP17_21690	COG0346	lactoylglutathione lyase activity
UP17_21695	COG1846	Transcriptional regulator
UP17_21700	COG2814	Major facilitator Superfamily
UP17_21715	COG1131	(ABC) transporter
UP17_21735	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
UP17_21735	COG0456	acetyltransferase
UP17_21745	COG2197	response regulator
UP17_21755	COG0586	Pfam SNARE associated Golgi protein
UP17_21770	COG0726	polysaccharide deacetylase
UP17_21775	COG3850	Histidine kinase
UP17_21775	COG5002	protein histidine kinase activity
UP17_21780	COG0745	RESPONSE REGULATOR receiver
UP17_21795	COG0725	ABC transporter, periplasmic molybdate-binding protein
UP17_21800	COG1910	domain protein
UP17_21820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UP17_21825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UP17_21840	COG3104	oligopeptide transport
UP17_21855	COG1595	DNA-templated transcription, initiation
UP17_21860	COG0726	polysaccharide deacetylase
UP17_21880	COG4303	Ethanolamine ammonia lyase large subunit
UP17_21885	COG4819	ethanolamine utilization protein
UP17_21890	COG3192	ethanolamine utilization protein
UP17_21915	COG4548	von Willebrand factor, type A
UP17_21920	COG0714	Associated with various cellular activities
UP17_21925	COG1114	Component of the transport system for branched-chain amino acids
UP17_21930	COG0110	maltose O-acetyltransferase activity
UP17_21935	COG0702	epimerase
UP17_21940	COG5566	PFAM Mor transcription activator
UP17_21960	COG0493	'glutamate synthase
UP17_21965	COG0067	glutamate synthase
UP17_21965	COG0069	glutamate synthase activity
UP17_21965	COG0070	glutamate synthase
UP17_21970	COG0583	DNA-binding transcription factor activity
UP17_21975	COG5577	PFAM Coat F domain
UP17_21990	COG1404	Belongs to the peptidase S8 family
UP17_21995	COG0495	leucyl-tRNA aminoacylation
UP17_22010	COG1242	4 iron, 4 sulfur cluster binding
UP17_22015	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
UP17_22025	COG2267	carboxylic ester hydrolase activity
UP17_22030	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UP17_22060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UP17_22090	COG1683	Conserved Protein
UP17_22100	COG1506	peptidase
UP17_22105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
UP17_22110	COG1116	anion transmembrane transporter activity
UP17_22115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
UP17_22135	COG0783	Belongs to the Dps family
UP17_22140	COG1854	S-ribosylhomocysteine lyase activity
UP17_22145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UP17_22155	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
UP17_22160	COG3290	protein histidine kinase activity
UP17_22165	COG4565	transcriptional regulatory protein
UP17_22170	COG4948	Mandelate Racemase Muconate Lactonizing
UP17_22175	COG0318	PFAM AMP-dependent synthetase and ligase
UP17_22180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
UP17_22190	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
UP17_22195	COG1169	isochorismate synthase
UP17_22200	COG1575	Belongs to the MenA family. Type 1 subfamily
UP17_22205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP17_22340	COG1285	pathogenesis
UP17_22355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_22380	COG0506	proline dehydrogenase activity
UP17_22385	COG1012	belongs to the aldehyde dehydrogenase family
UP17_22390	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_22395	COG2508	Transcriptional regulator
UP17_22400	COG1959	2 iron, 2 sulfur cluster binding
UP17_22405	COG5553	Cysteine dioxygenase type I
UP17_22410	COG2368	4-hydroxyphenylacetate
UP17_22415	COG1309	transcriptional regulator
UP17_22420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UP17_22425	COG1115	amino acid carrier protein
UP17_22430	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
UP17_22440	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
UP17_22445	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
UP17_22455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
UP17_22460	COG0640	Transcriptional regulator
UP17_22465	COG2814	Major facilitator Superfamily
UP17_22470	COG1994	Peptidase M50
UP17_22475	COG0833	amino acid
UP17_22505	COG1378	Sugar-specific transcriptional regulator TrmB
UP17_22520	COG3344	reverse transcriptase
UP17_22525	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UP17_22530	COG0604	alcohol dehydrogenase
UP17_22540	COG3773	Cell wall hydrolase
UP17_22545	COG3906	Belongs to the UPF0473 family
UP17_22550	COG1595	DNA-templated transcription, initiation
UP17_22560	COG0346	lactoylglutathione lyase activity
UP17_22565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UP17_22575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UP17_22580	COG0523	cobalamin synthesis protein
UP17_22585	COG0322	excinuclease ABC activity
UP17_22595	COG1785	Belongs to the alkaline phosphatase family
UP17_22605	COG3344	reverse transcriptase
UP17_22610	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
UP17_22620	COG0753	catalase activity
UP17_22630	COG1950	PFAM Membrane protein of
UP17_22635	COG0640	Transcriptional regulator
UP17_22640	COG2814	Major facilitator Superfamily
UP17_22650	COG1113	amino acid transport
UP17_22660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
UP17_22680	COG0697	spore germination
UP17_22690	COG2318	DinB family
UP17_22695	COG0456	acetyltransferase
UP17_22700	COG1191	sigma factor activity
UP17_22735	COG2814	Major facilitator Superfamily
UP17_22740	COG0531	amino acid
UP17_22745	COG1968	undecaprenyl-diphosphatase activity
UP17_22750	COG0584	glycerophosphoryl diester phosphodiesterase
UP17_22760	COG1388	LysM domain
UP17_22760	COG3858	chitin binding
UP17_22765	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UP17_22780	COG1979	alcohol dehydrogenase
UP17_22785	COG2155	Conserved Protein
UP17_22790	COG1098	S1 RNA binding domain
UP17_22795	COG0733	neurotransmitter:sodium symporter activity
UP17_22805	COG0436	Aminotransferase
UP17_22810	COG1522	sequence-specific DNA binding
UP17_22815	COG2267	carboxylic ester hydrolase activity
UP17_22825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
UP17_22830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UP17_22845	COG0456	acetyltransferase
UP17_22855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UP17_22865	COG5018	Exonuclease
UP17_22885	COG2111	Na H antiporter
UP17_22890	COG1006	Multisubunit Na H antiporter MnhC subunit
UP17_22895	COG0651	ATP synthesis coupled electron transport
UP17_22900	COG1863	multisubunit Na H antiporter MnhE subunit
UP17_22905	COG2212	antiporter activity
UP17_22920	COG2050	protein possibly involved in aromatic compounds catabolism
UP17_22935	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP17_22935	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UP17_22940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_22940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UP17_22950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UP17_22955	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
UP17_22965	COG3584	3D domain protein
UP17_22970	COG3344	reverse transcriptase
UP17_22985	COG1252	NADH dehydrogenase
UP17_22990	COG0492	ferredoxin-NADP+ reductase activity
UP17_22995	COG0316	Belongs to the HesB IscA family
UP17_23010	COG1252	NADH dehydrogenase
UP17_23015	COG4837	Protein of unknown function (DUF1462)
UP17_23020	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
UP17_23025	COG0083	homoserine kinase activity
UP17_23030	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UP17_23035	COG0460	homoserine dehydrogenase
UP17_23045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
UP17_23050	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UP17_23055	COG0647	UMP catabolic process
UP17_23060	COG2445	Protein of unknown function DUF86
UP17_23075	COG4470	Protein conserved in bacteria
UP17_23085	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
UP17_23090	COG0739	heme binding
UP17_23100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
UP17_23105	COG3377	Domain of unknown function (DUF1805)
UP17_23110	COG0737	Belongs to the 5'-nucleotidase family
UP17_23115	COG0730	response to heat
UP17_23120	COG1801	Protein of unknown function DUF72
UP17_23125	COG0719	Fe-S assembly protein
UP17_23130	COG0822	iron-sulfur transferase activity
UP17_23135	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UP17_23140	COG0719	Fe-S assembly protein
UP17_23145	COG0396	ATPase activity
UP17_23150	COG1464	Belongs to the NlpA lipoprotein family
UP17_23155	COG2011	ABC-type metal ion transport system permease component
UP17_23160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UP17_23170	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
UP17_23175	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
UP17_23180	COG0509	glycine decarboxylation via glycine cleavage system
UP17_23185	COG1393	Belongs to the ArsC family
UP17_23190	COG1960	acyl-CoA dehydrogenase activity
UP17_23195	COG0183	Belongs to the thiolase family
UP17_23200	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_23200	COG1024	Enoyl-CoA hydratase
UP17_23215	COG5577	PFAM Coat F domain
UP17_23220	COG0772	Belongs to the SEDS family
UP17_23225	COG1609	Transcriptional regulator
UP17_23230	COG0833	amino acid
UP17_23270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
UP17_23275	COG1368	sulfuric ester hydrolase activity
UP17_23280	COG4607	ABC-type enterochelin transport system periplasmic component
UP17_23285	COG4604	ABC transporter, ATP-binding protein
UP17_23290	COG4605	iron ion homeostasis
UP17_23295	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_23310	COG1657	PFAM Prenyltransferase squalene oxidase
UP17_23325	COG5002	protein histidine kinase activity
UP17_23325	COG3850	Histidine kinase
UP17_23330	COG0745	RESPONSE REGULATOR receiver
UP17_23335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_23340	COG2197	response regulator
UP17_23345	COG4585	Histidine kinase
UP17_23350	COG3239	Fatty acid desaturase
UP17_23360	COG3290	protein histidine kinase activity
UP17_23385	COG0583	DNA-binding transcription factor activity
UP17_23390	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UP17_23395	COG5609	conserved protein (DUF2294)
UP17_23400	COG3383	formate dehydrogenase (NAD+) activity
UP17_23405	COG2427	Protein of unknown function (DUF1641)
UP17_23425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UP17_23430	COG0557	exoribonuclease II activity
UP17_23435	COG1647	Serine aminopeptidase, S33
UP17_23440	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UP17_23450	COG1876	peptidase activity
UP17_23460	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
UP17_23465	COG0149	triose-phosphate isomerase activity
UP17_23470	COG0126	phosphoglycerate kinase activity
UP17_23475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UP17_23490	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UP17_23500	COG0740	serine-type endopeptidase activity
UP17_23505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
UP17_23515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
UP17_23520	COG1660	Displays ATPase and GTPase activities
UP17_23525	COG1051	belongs to the nudix hydrolase family
UP17_23530	COG0492	ferredoxin-NADP+ reductase activity
UP17_23535	COG0457	Tetratricopeptide repeat
UP17_23540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UP17_23540	COG0140	phosphoribosyl-ATP diphosphatase activity
UP17_23545	COG0107	imidazoleglycerol-phosphate synthase activity
UP17_23550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
UP17_23555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UP17_23560	COG0131	Imidazoleglycerol-phosphate dehydratase
UP17_23565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
UP17_23570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UP17_23575	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
UP17_23585	COG3764	Sortase (surface protein transpeptidase)
UP17_23590	COG0110	maltose O-acetyltransferase activity
UP17_23595	COG0546	phosphoglycolate phosphatase activity
UP17_23600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UP17_23605	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UP17_23615	COG3595	metallopeptidase activity
UP17_23620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UP17_23625	COG0556	nucleotide-excision repair
UP17_23630	COG4897	Protein conserved in bacteria
UP17_23635	COG0753	catalase activity
UP17_23645	COG2353	YceI-like domain
UP17_23650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_23655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_23660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP17_23665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP17_23670	COG0793	Belongs to the peptidase S41A family
UP17_23670	COG3409	Peptidoglycan-binding domain 1 protein
UP17_23675	COG3883	PFAM NLP P60 protein
UP17_23675	COG0791	NLP P60 protein
UP17_23680	COG2177	Part of the ABC transporter FtsEX involved in
UP17_23685	COG2884	Cell division ATP-binding protein ftsE
UP17_23700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
UP17_23705	COG0653	protein targeting
UP17_23710	COG1396	sequence-specific DNA binding
UP17_23715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
UP17_23725	COG1516	flagellar protein fliS
UP17_23730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UP17_23735	COG1334	flagellar protein FlaG
UP17_23745	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
UP17_23750	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UP17_23760	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UP17_23765	COG4786	Flagellar basal body rod
UP17_23765	COG1256	bacterial-type flagellum assembly
UP17_23775	COG2747	anti-sigma28 factor FlgM
UP17_23790	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
UP17_23795	COG1307	EDD domain protein, DegV family
UP17_23800	COG2197	response regulator
UP17_23805	COG4585	Histidine kinase
UP17_23810	COG1739	Uncharacterized protein family UPF0029
UP17_23815	COG1316	TRANSCRIPTIONal
UP17_23820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
UP17_23840	COG0728	peptidoglycan biosynthetic process
UP17_23845	COG0438	transferase activity, transferring glycosyl groups
UP17_23850	COG1134	teichoic acid transport
UP17_23855	COG1682	transport, permease protein
UP17_23875	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
UP17_23880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UP17_23885	COG1388	LysM domain
UP17_23885	COG0791	NLP P60 protein
UP17_23890	COG1316	TRANSCRIPTIONal
UP17_23895	COG1368	sulfuric ester hydrolase activity
UP17_23910	COG0653	protein targeting
UP17_23930	COG0768	penicillin binding
UP17_23950	COG4715	Zinc finger, swim domain protein
UP17_23955	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
UP17_23960	COG1279	arginine transmembrane transporter activity
UP17_23965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_23990	COG0747	negative chemotaxis
UP17_23995	COG4608	Belongs to the ABC transporter superfamily
UP17_24000	COG0444	Belongs to the ABC transporter superfamily
UP17_24010	COG0629	single-stranded DNA binding
UP17_24035	COG4786	Flagellar basal body rod
UP17_24040	COG4786	Flagellar basal body rod
UP17_24045	COG1077	Cell shape determining protein MreB Mrl
UP17_24050	COG1609	Transcriptional regulator
UP17_24055	COG0739	heme binding
UP17_24065	COG2385	sporulation resulting in formation of a cellular spore
UP17_24080	COG4836	Membrane
UP17_24085	COG1007	ATP synthesis coupled electron transport
UP17_24090	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_24095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UP17_24100	COG0713	ATP synthesis coupled electron transport
UP17_24110	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_24120	COG0649	NAD binding
UP17_24125	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_24130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_24135	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UP17_24145	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UP17_24150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
UP17_24160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP17_24170	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UP17_24175	COG0356	it plays a direct role in the translocation of protons across the membrane
UP17_24185	COG1404	Belongs to the peptidase S8 family
UP17_24190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UP17_24195	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UP17_24210	COG0698	ribose 5-phosphate isomerase
UP17_24225	COG1971	Probably functions as a manganese efflux pump
UP17_24230	COG0009	L-threonylcarbamoyladenylate synthase
UP17_24240	COG2890	protein-(glutamine-N5) methyltransferase activity
UP17_24245	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UP17_24255	COG1435	thymidine kinase activity
UP17_24265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UP17_24270	COG1494	fructose-1,6-bisphosphatase
UP17_24275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
UP17_24280	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
UP17_24290	COG2204	response regulator
UP17_24295	COG4821	SIS domain
UP17_24300	COG0504	CTP synthase activity
UP17_24305	COG3343	RNA polymerase activity
UP17_24310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_24310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
UP17_24310	COG1703	isobutyryl-CoA mutase activity
UP17_24320	COG1960	acyl-CoA dehydrogenase activity
UP17_24325	COG1960	acyl-CoA dehydrogenase activity
UP17_24330	COG1250	3-hydroxyacyl-CoA dehydrogenase
UP17_24335	COG0183	Belongs to the thiolase family
UP17_24340	COG2181	nitrate reductase activity
UP17_24340	COG0247	lactate metabolic process
UP17_24345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
UP17_24355	COG0018	arginyl-trna synthetase
UP17_24365	COG0010	Belongs to the arginase family
UP17_24370	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
UP17_24375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
UP17_24385	COG1994	Peptidase M50
UP17_24395	COG3465	dGTPase activity
UP17_24400	COG1078	dGTPase activity
UP17_24405	COG4844	belongs to the
UP17_24420	COG0280	phosphate acetyltransferase
UP17_24435	COG2363	Small membrane protein
UP17_24445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UP17_24460	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
UP17_24465	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
UP17_24470	COG0314	molybdopterin synthase activity
UP17_24475	COG0746	molybdenum cofactor guanylyltransferase activity
UP17_24480	COG0351	phosphomethylpyrimidine kinase
UP17_24485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
UP17_24495	COG2814	Major facilitator Superfamily
UP17_24500	COG1846	Transcriptional regulator
UP17_24510	COG0561	phosphatase activity
UP17_24520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
UP17_24545	COG2096	Adenosyltransferase
UP17_24555	COG0588	phosphoglycerate mutase activity
UP17_24560	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
UP17_24570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UP17_24575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
UP17_24580	COG1120	ATPase activity
UP17_24585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UP17_24590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UP17_24605	COG3397	chitin binding
UP17_24610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UP17_24620	COG0551	DNA topoisomerase type I activity
UP17_24620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UP17_24625	COG0488	(ABC) transporter
UP17_24635	COG3173	Aminoglycoside phosphotransferase
UP17_24645	COG2252	PERMEase
UP17_24670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UP17_24670	COG0723	plastoquinol--plastocyanin reductase activity
UP17_24675	COG4895	conserved protein (DUF2196)
UP17_24685	COG0788	formyltetrahydrofolate deformylase activity
UP17_24690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UP17_24705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UP17_24710	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_24710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UP17_24715	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
UP17_24720	COG5002	protein histidine kinase activity
UP17_24725	COG0745	RESPONSE REGULATOR receiver
UP17_24740	COG3162	membrane
UP17_24745	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UP17_24760	COG2267	carboxylic ester hydrolase activity
UP17_24765	COG1301	dicarboxylic acid transport
UP17_24775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
UP17_24785	COG0583	DNA-binding transcription factor activity
UP17_24790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
UP17_24800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
UP17_24825	COG4264	IucA IucC family
UP17_24830	COG0076	glutamate decarboxylase activity
UP17_24845	COG2195	Cleaves the N-terminal amino acid of tripeptides
UP17_24850	COG0693	protein deglycase activity
UP17_24850	COG0753	catalase activity
UP17_24860	COG2329	Antibiotic biosynthesis monooxygenase
UP17_24865	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UP17_24870	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
UP17_24875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UP17_24880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
UP17_24885	COG4853	Protein conserved in bacteria
UP17_24895	COG5002	protein histidine kinase activity
UP17_24900	COG0745	RESPONSE REGULATOR receiver
UP17_24905	COG0739	heme binding
UP17_24905	COG0741	lytic transglycosylase activity
UP17_24905	COG1196	nuclear chromosome segregation
UP17_24935	COG0305	Participates in initiation and elongation during chromosome replication
UP17_24940	COG0359	binds to the 23S rRNA
UP17_24945	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
UP17_24955	COG3344	reverse transcriptase
UP17_24960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UP17_24965	COG0629	single-stranded DNA binding
UP17_24970	COG0360	Binds together with S18 to 16S ribosomal RNA
UP17_24975	COG0012	GTP binding
UP17_24980	COG4481	Protein conserved in bacteria
UP17_24985	COG0668	transmembrane transport
UP17_25000	COG1475	DNA binding
UP17_25005	COG1192	Involved in chromosome partitioning
UP17_25010	COG1475	DNA binding
UP17_25015	COG0357	Ribosomal RNA small subunit methyltransferase G
UP17_25020	COG0445	tRNA wobble uridine modification
UP17_25030	COG3344	reverse transcriptase
UP17_25035	COG1847	R3H domain protein
UP17_25040	COG0706	membrane insertase activity
UP17_25045	COG0594	ribonuclease P activity
UP17_25075	COG3706	GGDEF domain
UP17_25095	COG1309	transcriptional regulator
UP17_25160	COG2801	Transposase and inactivated derivatives
UP17_25210	COG0456	acetyltransferase
UP17_25220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
UP17_25235	COG0789	Transcriptional regulator
UP17_25235	COG4978	Transcriptional regulator
UP17_25240	COG1811	Na channel or pump
UP17_25260	COG3708	Transcriptional regulator
UP17_25260	COG2207	Transcriptional regulator
UP17_25280	COG4974	Belongs to the 'phage' integrase family
UP17_25290	COG1525	nuclease
UP17_25325	COG1401	restriction endodeoxyribonuclease activity
UP17_25340	COG1396	sequence-specific DNA binding
UP17_25430	COG4974	Belongs to the 'phage' integrase family
UP17_25435	COG3654	unkown
UP17_25455	COG3634	alkyl hydroperoxide reductase activity
UP17_25460	COG0450	alkyl hydroperoxide reductase
UP17_25465	COG0833	amino acid
UP17_25475	COG1982	Orn Lys Arg decarboxylase major
UP17_25480	COG2249	NAD(P)H dehydrogenase (quinone) activity
UP17_25485	COG1733	regulation of RNA biosynthetic process
UP17_25490	COG0110	maltose O-acetyltransferase activity
UP17_25535	COG0534	Mate efflux family protein
UP17_25540	COG4608	Belongs to the ABC transporter superfamily
UP17_25550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UP17_25555	COG0601	transmembrane transport
UP17_25560	COG0747	negative chemotaxis
UP17_25670	COG0791	NLP P60 protein
UP17_25670	COG0741	lytic transglycosylase activity
UP17_25785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
UP17_25795	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
UP17_25835	COG4974	Belongs to the 'phage' integrase family