locus-tag	class	description
BSM4216_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BSM4216_0002	COG0592	DNA-directed DNA polymerase activity
BSM4216_0004	COG0187	DNA topoisomerase II activity
BSM4216_0005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSM4216_0006	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BSM4216_0011	COG0517	IMP dehydrogenase activity
BSM4216_0011	COG0516	GMP reductase activity
BSM4216_0014	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BSM4216_0015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BSM4216_0017	COG1388	LysM domain
BSM4216_0017	COG3858	chitin binding
BSM4216_0018	COG0590	tRNA wobble adenosine to inosine editing
BSM4216_0019	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BSM4216_0020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BSM4216_0021	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BSM4216_0031	COG1982	Orn Lys Arg decarboxylase major
BSM4216_0032	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BSM4216_0034	COG1728	Protein conserved in bacteria
BSM4216_0035	COG0470	DNA polymerase III
BSM4216_0036	COG1774	PSP1 C-terminal conserved region
BSM4216_0037	COG4467	Involved in initiation control of chromosome replication
BSM4216_0038	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
BSM4216_0039	COG2827	Endonuclease containing a URI domain
BSM4216_0040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BSM4216_0041	COG2002	toxin-antitoxin pair type II binding
BSM4216_0044	COG0084	hydrolase, TatD family'
BSM4216_0045	COG3583	domain protein
BSM4216_0045	COG3584	3D domain protein
BSM4216_0047	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BSM4216_0050	COG4466	Protein conserved in bacteria
BSM4216_0053	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BSM4216_0054	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSM4216_0055	COG0251	oxidation-reduction process
BSM4216_0056	COG2088	sporulation resulting in formation of a cellular spore
BSM4216_0057	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BSM4216_0058	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BSM4216_0060	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BSM4216_0063	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BSM4216_0064	COG2002	toxin-antitoxin pair type II binding
BSM4216_0065	COG2244	polysaccharide biosynthetic process
BSM4216_0066	COG3956	TIGRFAM MazG family protein
BSM4216_0067	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BSM4216_0070	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BSM4216_0071	COG1098	S1 RNA binding domain
BSM4216_0074	COG2208	phosphoserine phosphatase activity
BSM4216_0075	COG2304	oxidoreductase activity
BSM4216_0076	COG0515	serine threonine protein kinase
BSM4216_0079	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BSM4216_0081	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BSM4216_0082	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BSM4216_0083	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSM4216_0084	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BSM4216_0085	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BSM4216_0086	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BSM4216_0087	COG1396	sequence-specific DNA binding
BSM4216_0088	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BSM4216_0106	COG3880	PFAM UvrB UvrC protein
BSM4216_0107	COG3869	Catalyzes the specific phosphorylation of arginine residues in
BSM4216_0108	COG0542	response to heat
BSM4216_0109	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BSM4216_0111	COG4956	integral membrane protein (PIN domain superfamily)
BSM4216_0112	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BSM4216_0113	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BSM4216_0115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BSM4216_0117	COG1045	serine acetyltransferase
BSM4216_0118	COG0215	cysteine-tRNA ligase activity
BSM4216_0119	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
BSM4216_0120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSM4216_0121	COG3688	RNA-binding protein containing a PIN domain
BSM4216_0123	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BSM4216_0124	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSM4216_0125	COG0250	Participates in transcription elongation, termination and antitermination
BSM4216_0126	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BSM4216_0127	COG0081	regulation of translation
BSM4216_0129	COG0222	ribosome binding
BSM4216_0130	COG2813	Specifically methylates the guanine in position
BSM4216_0131	COG0085	RNA polymerase activity
BSM4216_0132	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BSM4216_0133	COG1358	cellular component organization or biogenesis
BSM4216_0134	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BSM4216_0135	COG0049	tRNA binding
BSM4216_0136	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BSM4216_0137	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BSM4216_0140	COG0051	transcription antitermination factor activity, RNA binding
BSM4216_0141	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BSM4216_0142	COG0088	Forms part of the polypeptide exit tunnel
BSM4216_0143	COG0089	rRNA binding
BSM4216_0144	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BSM4216_0145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BSM4216_0146	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BSM4216_0147	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BSM4216_0148	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BSM4216_0149	COG0255	Belongs to the universal ribosomal protein uL29 family
BSM4216_0150	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BSM4216_0151	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BSM4216_0152	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BSM4216_0153	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BSM4216_0154	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSM4216_0155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BSM4216_0156	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BSM4216_0157	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BSM4216_0158	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BSM4216_0159	COG1841	ribosomal large subunit assembly
BSM4216_0160	COG0200	Binds to the 23S rRNA
BSM4216_0161	COG0201	protein transport
BSM4216_0162	COG0563	adenylate kinase activity
BSM4216_0164	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BSM4216_0165	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BSM4216_0166	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BSM4216_0167	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BSM4216_0168	COG0202	RNA polymerase activity
BSM4216_0169	COG0203	ribosomal protein L17
BSM4216_0171	COG1122	ATPase activity
BSM4216_0172	COG1122	ATPase activity
BSM4216_0173	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BSM4216_0174	COG0101	tRNA pseudouridine synthase activity
BSM4216_0175	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BSM4216_0176	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BSM4216_0179	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_0181	COG0489	protein tyrosine kinase activity
BSM4216_0183	COG2194	sulfuric ester hydrolase activity
BSM4216_0186	COG0726	polysaccharide deacetylase
BSM4216_0203	COG1595	DNA-templated transcription, initiation
BSM4216_0204	COG5662	AntiSigma factor
BSM4216_0205	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
BSM4216_0206	COG4856	YbbR-like protein
BSM4216_0207	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSM4216_0208	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BSM4216_0212	COG3973	AAA domain
BSM4216_0216	COG0346	lactoylglutathione lyase activity
BSM4216_0219	COG1819	glycosyl
BSM4216_0220	COG1247	-acetyltransferase
BSM4216_0224	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_0225	COG1960	acyl-CoA dehydrogenase activity
BSM4216_0226	COG1960	acyl-CoA dehydrogenase activity
BSM4216_0228	COG1960	acyl-CoA dehydrogenase activity
BSM4216_0230	COG0500	methyltransferase
BSM4216_0235	COG2814	Major facilitator Superfamily
BSM4216_0242	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_0246	COG4948	Mandelate Racemase Muconate Lactonizing
BSM4216_0249	COG0789	Transcriptional regulator
BSM4216_0251	COG2080	2 iron, 2 sulfur cluster binding
BSM4216_0257	COG3706	GGDEF domain
BSM4216_0257	COG0745	RESPONSE REGULATOR receiver
BSM4216_0262	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSM4216_0263	COG0022	dehydrogenase e1 component
BSM4216_0268	COG0726	polysaccharide deacetylase
BSM4216_0274	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_0275	COG4521	taurine ABC transporter
BSM4216_0277	COG2175	clavaminate synthase activity
BSM4216_0278	COG2076	Multidrug Resistance protein
BSM4216_0285	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
BSM4216_0294	COG0515	serine threonine protein kinase
BSM4216_0294	COG2815	serine threonine protein kinase
BSM4216_0295	COG2205	protein histidine kinase activity
BSM4216_0296	COG0745	RESPONSE REGULATOR receiver
BSM4216_0298	COG2814	Major facilitator Superfamily
BSM4216_0300	COG1664	Polymer-forming cytoskeletal
BSM4216_0301	COG0789	Transcriptional regulator
BSM4216_0306	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_0310	COG1335	isochorismatase
BSM4216_0314	COG3414	Phosphotransferase system galactitol-specific IIB component
BSM4216_0315	COG3775	system Galactitol-specific IIC component
BSM4216_0316	COG1063	alcohol dehydrogenase
BSM4216_0318	COG1063	alcohol dehydrogenase
BSM4216_0319	COG1349	DNA-binding transcription factor activity
BSM4216_0321	COG1070	Carbohydrate kinase
BSM4216_0322	COG4806	L-rhamnose isomerase
BSM4216_0323	COG0235	Class ii aldolase
BSM4216_0324	COG3254	rhamnose metabolic process
BSM4216_0325	COG2814	Major facilitator Superfamily
BSM4216_0326	COG0697	spore germination
BSM4216_0327	COG0204	Acyl-transferase
BSM4216_0333	COG0789	Transcriptional regulator
BSM4216_0334	COG2323	membrane
BSM4216_0335	COG0702	epimerase
BSM4216_0340	COG1404	Belongs to the peptidase S8 family
BSM4216_0346	COG0475	glutathione-regulated potassium exporter activity
BSM4216_0347	COG0527	aspartate kinase activity
BSM4216_0351	COG0693	protein deglycase activity
BSM4216_0352	COG3835	regulator
BSM4216_0353	COG0277	FAD linked oxidase domain protein
BSM4216_0354	COG0247	lactate metabolic process
BSM4216_0357	COG3655	Transcriptional regulator
BSM4216_0358	COG3739	integral membrane protein
BSM4216_0375	COG0559	Belongs to the binding-protein-dependent transport system permease family
BSM4216_0376	COG4177	L-phenylalanine transmembrane transporter activity
BSM4216_0377	COG0411	ABC transporter
BSM4216_0383	COG2353	YceI-like domain
BSM4216_0385	COG1737	Transcriptional regulator
BSM4216_0386	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BSM4216_0387	COG1268	BioY protein
BSM4216_0388	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_0389	COG0183	Belongs to the thiolase family
BSM4216_0390	COG4989	oxidoreductase activity
BSM4216_0392	COG0604	alcohol dehydrogenase
BSM4216_0405	COG1131	(ABC) transporter
BSM4216_0406	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BSM4216_0413	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BSM4216_0414	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BSM4216_0415	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
BSM4216_0419	COG0730	response to heat
BSM4216_0423	COG1609	Transcriptional regulator
BSM4216_0426	COG0235	Class ii aldolase
BSM4216_0427	COG2160	L-arabinose isomerase activity
BSM4216_0428	COG2433	Pfam Transposase IS66
BSM4216_0450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BSM4216_0452	COG3344	reverse transcriptase
BSM4216_0454	COG1297	OPT oligopeptide transporter protein
BSM4216_0457	COG3584	3D domain protein
BSM4216_0457	COG1388	LysM domain
BSM4216_0459	COG1388	LysM domain
BSM4216_0459	COG3584	3D domain protein
BSM4216_0460	COG2814	Major facilitator Superfamily
BSM4216_0465	COG0768	penicillin binding
BSM4216_0466	COG0791	NLP P60 protein
BSM4216_0466	COG1388	LysM domain
BSM4216_0468	COG3344	reverse transcriptase
BSM4216_0470	COG0653	protein targeting
BSM4216_0471	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSM4216_0472	COG1316	TRANSCRIPTIONal
BSM4216_0473	COG1739	Uncharacterized protein family UPF0029
BSM4216_0474	COG4585	Histidine kinase
BSM4216_0475	COG2197	response regulator
BSM4216_0476	COG2188	Transcriptional regulator
BSM4216_0479	COG0366	Alpha amylase catalytic
BSM4216_0481	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_0481	COG1263	PTS System
BSM4216_0482	COG1307	EDD domain protein, DegV family
BSM4216_0483	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BSM4216_0484	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
BSM4216_0485	COG1040	competence protein
BSM4216_0489	COG4786	Flagellar basal body rod
BSM4216_0489	COG1256	bacterial-type flagellum assembly
BSM4216_0490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSM4216_0492	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BSM4216_0493	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BSM4216_0499	COG1334	flagellar protein FlaG
BSM4216_0500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BSM4216_0501	COG1516	flagellar protein fliS
BSM4216_0506	COG0653	protein targeting
BSM4216_0507	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BSM4216_0509	COG0745	RESPONSE REGULATOR receiver
BSM4216_0510	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BSM4216_0517	COG3344	reverse transcriptase
BSM4216_0518	COG2884	Cell division ATP-binding protein ftsE
BSM4216_0519	COG2177	Part of the ABC transporter FtsEX involved in
BSM4216_0520	COG3883	PFAM NLP P60 protein
BSM4216_0520	COG0791	NLP P60 protein
BSM4216_0522	COG3328	transposase activity
BSM4216_0523	COG0456	acetyltransferase
BSM4216_0527	COG3409	Peptidoglycan-binding domain 1 protein
BSM4216_0527	COG0793	Belongs to the peptidase S41A family
BSM4216_0528	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSM4216_0533	COG0697	spore germination
BSM4216_0535	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
BSM4216_0537	COG0556	nucleotide-excision repair
BSM4216_0538	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BSM4216_0539	COG0363	glucosamine-6-phosphate deaminase activity
BSM4216_0541	COG1263	PTS System
BSM4216_0541	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_0541	COG2190	(PTS) system
BSM4216_0542	COG1609	Transcriptional regulator
BSM4216_0545	COG1983	PspC domain protein
BSM4216_0546	COG1950	PFAM Membrane protein of
BSM4216_0547	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BSM4216_0549	COG0671	phosphoesterase, PA-phosphatase related
BSM4216_0550	COG0586	Pfam SNARE associated Golgi protein
BSM4216_0554	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BSM4216_0555	COG0546	phosphoglycolate phosphatase activity
BSM4216_0556	COG0110	maltose O-acetyltransferase activity
BSM4216_0559	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BSM4216_0560	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BSM4216_0561	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BSM4216_0562	COG0131	Imidazoleglycerol-phosphate dehydratase
BSM4216_0563	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BSM4216_0564	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BSM4216_0565	COG0107	imidazoleglycerol-phosphate synthase activity
BSM4216_0566	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BSM4216_0566	COG0140	phosphoribosyl-ATP diphosphatase activity
BSM4216_0567	COG0457	Tetratricopeptide repeat
BSM4216_0568	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_0571	COG1051	belongs to the nudix hydrolase family
BSM4216_0572	COG1660	Displays ATPase and GTPase activities
BSM4216_0573	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BSM4216_0575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSM4216_0576	COG0740	serine-type endopeptidase activity
BSM4216_0579	COG2258	MOSC domain
BSM4216_0582	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BSM4216_0587	COG0126	phosphoglycerate kinase activity
BSM4216_0588	COG0149	triose-phosphate isomerase activity
BSM4216_0590	COG0148	phosphopyruvate hydratase activity
BSM4216_0591	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BSM4216_0592	COG1647	Serine aminopeptidase, S33
BSM4216_0593	COG0557	exoribonuclease II activity
BSM4216_0594	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BSM4216_0597	COG3226	Transcriptional regulator
BSM4216_0601	COG0583	DNA-binding transcription factor activity
BSM4216_0603	COG1988	membrane-bound metal-dependent
BSM4216_0606	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSM4216_0607	COG0022	dehydrogenase e1 component
BSM4216_0608	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSM4216_0609	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSM4216_0612	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_0613	COG3284	Transcriptional regulator
BSM4216_0619	COG2199	diguanylate cyclase activity
BSM4216_0619	COG2203	Gaf domain
BSM4216_0620	COG0673	inositol 2-dehydrogenase activity
BSM4216_0623	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BSM4216_0625	COG0840	transmembrane signaling receptor activity
BSM4216_0628	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSM4216_0629	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_0632	COG2204	response regulator
BSM4216_0633	COG3852	Histidine kinase
BSM4216_0636	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BSM4216_0638	COG2079	MmgE PrpD family protein
BSM4216_0640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BSM4216_0641	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
BSM4216_0642	COG1733	regulation of RNA biosynthetic process
BSM4216_0643	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSM4216_0644	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
BSM4216_0651	COG0482	sulfurtransferase activity
BSM4216_0656	COG0535	radical SAM domain protein
BSM4216_0662	COG4464	protein tyrosine phosphatase activity
BSM4216_0663	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSM4216_0666	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BSM4216_0667	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BSM4216_0670	COG0840	transmembrane signaling receptor activity
BSM4216_0671	COG1316	TRANSCRIPTIONal
BSM4216_0676	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSM4216_0677	COG2022	thiamine diphosphate biosynthetic process
BSM4216_0678	COG2104	thiamine diphosphate biosynthetic process
BSM4216_0679	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSM4216_0680	COG0352	thiamine-phosphate diphosphorylase activity
BSM4216_0682	COG4512	PFAM Accessory gene regulator B
BSM4216_0687	COG3852	Histidine kinase
BSM4216_0690	COG0531	amino acid
BSM4216_0692	COG1522	sequence-specific DNA binding
BSM4216_0693	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BSM4216_0694	COG1984	allophanate hydrolase subunit 2
BSM4216_0695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BSM4216_0700	COG1113	amino acid transport
BSM4216_0701	COG3689	TIGRFAM TIGR03943 family protein
BSM4216_0702	COG0701	Predicted permease
BSM4216_0704	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_0705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_0706	COG1116	anion transmembrane transporter activity
BSM4216_0709	COG0833	amino acid
BSM4216_0714	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BSM4216_0720	COG1215	transferase activity, transferring glycosyl groups
BSM4216_0723	COG0824	Thioesterase
BSM4216_0724	COG0431	NADPH-dependent FMN reductase
BSM4216_0725	COG4106	trans-aconitate 2-methyltransferase activity
BSM4216_0726	COG1349	DNA-binding transcription factor activity
BSM4216_0727	COG1105	Belongs to the carbohydrate kinase PfkB family
BSM4216_0728	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSM4216_0728	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSM4216_0728	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BSM4216_0729	COG0551	DNA topoisomerase type I activity
BSM4216_0729	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSM4216_0731	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BSM4216_0732	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BSM4216_0740	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_0742	COG2244	polysaccharide biosynthetic process
BSM4216_0748	COG0288	reversible hydration of carbon dioxide
BSM4216_0750	COG1410	methionine synthase
BSM4216_0750	COG0646	methionine synthase
BSM4216_0751	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BSM4216_0751	COG0646	methionine synthase
BSM4216_0752	COG1077	Cell shape determining protein MreB Mrl
BSM4216_0753	COG1607	acyl-coa hydrolase
BSM4216_0754	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BSM4216_0755	COG0493	'glutamate synthase
BSM4216_0757	COG0067	glutamate synthase
BSM4216_0757	COG0070	glutamate synthase
BSM4216_0757	COG0069	glutamate synthase activity
BSM4216_0758	COG0583	DNA-binding transcription factor activity
BSM4216_0759	COG2309	aminopeptidase activity
BSM4216_0760	COG3189	MarR family transcriptional regulator
BSM4216_0761	COG1959	2 iron, 2 sulfur cluster binding
BSM4216_0763	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSM4216_0766	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BSM4216_0767	COG1360	Flagellar Motor Protein
BSM4216_0768	COG0693	protein deglycase activity
BSM4216_0769	COG0024	Methionine aminopeptidase
BSM4216_0770	COG4840	Belongs to the UPF0435 family
BSM4216_0774	COG2217	Heavy metal translocating P-type atpase
BSM4216_0776	COG0387	Pfam Sodium calcium exchanger
BSM4216_0785	COG3093	addiction module antidote protein HigA
BSM4216_0793	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BSM4216_0794	COG1136	(ABC) transporter
BSM4216_0795	COG0577	efflux transmembrane transporter activity
BSM4216_0797	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSM4216_0805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BSM4216_0815	COG1988	membrane-bound metal-dependent
BSM4216_0817	COG1194	a g-specific adenine glycosylase
BSM4216_0820	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_0824	COG3557	Belongs to the UPF0374 family
BSM4216_0826	COG1132	(ABC) transporter
BSM4216_0827	COG4129	membrane
BSM4216_0828	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSM4216_0830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BSM4216_0833	COG2096	Adenosyltransferase
BSM4216_0834	COG0735	belongs to the Fur family
BSM4216_0858	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_0859	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_0860	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BSM4216_0861	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_0862	COG0765	amino acid transport
BSM4216_0863	COG0765	amino acid transport
BSM4216_0864	COG1126	abc transporter atp-binding protein
BSM4216_0866	COG1473	amidohydrolase
BSM4216_0873	COG3328	transposase activity
BSM4216_0877	COG1113	amino acid transport
BSM4216_0879	COG2211	Major facilitator Superfamily
BSM4216_0881	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BSM4216_0882	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BSM4216_0884	COG2808	Putative FMN-binding domain
BSM4216_0885	COG1280	lysine exporter protein (LysE YggA)
BSM4216_0886	COG0531	amino acid
BSM4216_0889	COG1247	-acetyltransferase
BSM4216_0893	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BSM4216_0897	COG0778	Nitroreductase
BSM4216_0900	COG2766	serine protein kinase
BSM4216_0908	COG1086	Polysaccharide biosynthesis protein
BSM4216_0909	COG2718	Belongs to the UPF0229 family
BSM4216_0911	COG2718	Belongs to the UPF0229 family
BSM4216_0913	COG3402	PFAM membrane-flanked domain
BSM4216_0918	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSM4216_0920	COG2323	membrane
BSM4216_0923	COG3104	oligopeptide transport
BSM4216_0926	COG2252	PERMEase
BSM4216_0929	COG0306	phosphate transporter
BSM4216_0930	COG1392	Phosphate transport regulator
BSM4216_0931	COG0656	L-ascorbic acid biosynthetic process
BSM4216_0932	COG0564	pseudouridine synthase activity
BSM4216_0937	COG2719	SpoVR family
BSM4216_0938	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSM4216_0939	COG0390	transport system, permease component
BSM4216_0944	COG1414	Transcriptional regulator
BSM4216_0952	COG2162	N-hydroxyarylamine O-acetyltransferase activity
BSM4216_0953	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSM4216_0954	COG0725	ABC transporter, periplasmic molybdate-binding protein
BSM4216_0955	COG4149	molybdate abc transporter
BSM4216_0958	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_0961	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSM4216_0962	COG0129	dihydroxy-acid dehydratase activity
BSM4216_0963	COG0028	Belongs to the TPP enzyme family
BSM4216_0964	COG0440	acetolactate synthase activity
BSM4216_0965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BSM4216_0966	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSM4216_0968	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BSM4216_0969	COG0066	3-isopropylmalate dehydratase activity
BSM4216_0971	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSM4216_0972	COG0512	Glutamine amidotransferase of anthranilate synthase
BSM4216_0973	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BSM4216_0977	COG0189	ligase activity
BSM4216_0978	COG0189	ligase activity
BSM4216_0981	COG4399	Belongs to the UPF0754 family
BSM4216_0982	COG3679	Belongs to the UPF0342 family
BSM4216_0987	COG0561	phosphatase activity
BSM4216_0988	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSM4216_0990	COG0420	3'-5' exonuclease activity
BSM4216_0991	COG4717	serine-type aminopeptidase activity
BSM4216_0993	COG3481	metal-dependent phosphohydrolase, HD sub domain
BSM4216_0995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BSM4216_1000	COG1846	Transcriptional regulator
BSM4216_1005	COG0537	adenosine 5'-monophosphoramidase activity
BSM4216_1008	COG1131	(ABC) transporter
BSM4216_1009	COG4473	ABC transporter
BSM4216_1010	COG3069	C4-dicarboxylate transmembrane transporter activity
BSM4216_1011	COG2329	Antibiotic biosynthesis monooxygenase
BSM4216_1013	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BSM4216_1016	COG1309	transcriptional regulator
BSM4216_1017	COG1511	domain protein
BSM4216_1019	COG1234	tRNA 3'-trailer cleavage
BSM4216_1022	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_1024	COG1024	Enoyl-CoA hydratase
BSM4216_1027	COG0501	Belongs to the peptidase M48B family
BSM4216_1029	COG5582	Belongs to the UPF0302 family
BSM4216_1030	COG4903	ComK protein
BSM4216_1032	COG0398	Pfam SNARE associated Golgi protein
BSM4216_1038	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
BSM4216_1039	COG1074	ATP-dependent DNA helicase activity
BSM4216_1047	COG2311	Membrane
BSM4216_1048	COG0179	Fumarylacetoacetate (FAA) hydrolase
BSM4216_1051	COG0367	asparagine synthase
BSM4216_1055	COG1666	GTP binding
BSM4216_1058	COG1307	EDD domain protein, DegV family
BSM4216_1059	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSM4216_1061	COG1073	alpha beta
BSM4216_1062	COG2151	metal-sulfur cluster biosynthetic enzyme
BSM4216_1065	COG0542	response to heat
BSM4216_1067	COG2267	carboxylic ester hydrolase activity
BSM4216_1070	COG1744	ABC transporter substrate-binding protein PnrA-like
BSM4216_1073	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BSM4216_1074	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BSM4216_1075	COG4585	Histidine kinase
BSM4216_1076	COG2197	response regulator
BSM4216_1078	COG1131	(ABC) transporter
BSM4216_1081	COG5504	Zn-dependent protease
BSM4216_1085	COG0180	Tryptophanyl-tRNA synthetase
BSM4216_1088	COG4166	transmembrane transport
BSM4216_1089	COG0601	transmembrane transport
BSM4216_1090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BSM4216_1091	COG0444	Belongs to the ABC transporter superfamily
BSM4216_1092	COG4608	Belongs to the ABC transporter superfamily
BSM4216_1096	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_1097	COG0765	amino acid transport
BSM4216_1098	COG0765	amino acid transport
BSM4216_1099	COG1393	Belongs to the ArsC family
BSM4216_1100	COG5002	protein histidine kinase activity
BSM4216_1101	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BSM4216_1102	COG0573	inorganic phosphate transmembrane transporter activity
BSM4216_1103	COG0581	inorganic phosphate transmembrane transporter activity
BSM4216_1104	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSM4216_1105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BSM4216_1106	COG0704	Plays a role in the regulation of phosphate uptake
BSM4216_1109	COG1349	DNA-binding transcription factor activity
BSM4216_1110	COG1276	copper resistance
BSM4216_1110	COG2372	response to copper ion
BSM4216_1111	COG4549	nuclear export factor GLE1
BSM4216_1113	COG4862	establishment of competence for transformation
BSM4216_1115	COG1164	Oligoendopeptidase f
BSM4216_1118	COG3853	Toxic anion resistance protein (TelA)
BSM4216_1119	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
BSM4216_1122	COG2346	COG2346, Truncated hemoglobins
BSM4216_1123	COG0741	lytic transglycosylase activity
BSM4216_1124	COG4116	CYTH
BSM4216_1126	COG2357	RelA SpoT domain protein
BSM4216_1127	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BSM4216_1128	COG0564	pseudouridine synthase activity
BSM4216_1130	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSM4216_1146	COG2153	protein acetylation
BSM4216_1147	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BSM4216_1148	COG2382	esterase
BSM4216_1151	COG1063	alcohol dehydrogenase
BSM4216_1156	COG0386	Belongs to the glutathione peroxidase family
BSM4216_1157	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BSM4216_1163	COG0431	NADPH-dependent FMN reductase
BSM4216_1167	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_1168	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_1175	COG1247	-acetyltransferase
BSM4216_1180	COG0531	amino acid
BSM4216_1186	COG0579	oxidoreductase
BSM4216_1192	COG0535	radical SAM domain protein
BSM4216_1194	COG1131	(ABC) transporter
BSM4216_1195	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSM4216_1197	COG0612	Peptidase, M16
BSM4216_1199	COG1959	2 iron, 2 sulfur cluster binding
BSM4216_1200	COG2910	NAD(P)H-binding
BSM4216_1202	COG1125	glycine betaine transport
BSM4216_1202	COG0517	IMP dehydrogenase activity
BSM4216_1203	COG1732	Glycine betaine
BSM4216_1220	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BSM4216_1225	COG2318	DinB family
BSM4216_1228	COG2814	Major facilitator Superfamily
BSM4216_1231	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BSM4216_1234	COG1131	(ABC) transporter
BSM4216_1237	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BSM4216_1240	COG0523	cobalamin synthesis protein
BSM4216_1241	COG2814	Major facilitator Superfamily
BSM4216_1242	COG0196	riboflavin kinase activity
BSM4216_1243	COG5583	Uncharacterized small protein (DUF2292)
BSM4216_1244	COG0778	Nitroreductase
BSM4216_1245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSM4216_1246	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BSM4216_1248	COG0561	phosphatase activity
BSM4216_1249	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BSM4216_1250	COG0803	Belongs to the bacterial solute-binding protein 9 family
BSM4216_1251	COG1121	(ABC) transporter
BSM4216_1252	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BSM4216_1254	COG0701	Predicted permease
BSM4216_1257	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSM4216_1258	COG3162	membrane
BSM4216_1261	COG0076	glutamate decarboxylase activity
BSM4216_1268	COG1120	ATPase activity
BSM4216_1269	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_1270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_1271	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSM4216_1273	COG1120	ATPase activity
BSM4216_1274	COG0778	Nitroreductase
BSM4216_1275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BSM4216_1276	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_1277	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BSM4216_1281	COG1082	Xylose isomerase domain protein TIM barrel
BSM4216_1284	COG2259	Doxx family
BSM4216_1285	COG0346	lactoylglutathione lyase activity
BSM4216_1286	COG0400	carboxylic ester hydrolase activity
BSM4216_1287	COG2514	catechol 2,3-dioxygenase activity
BSM4216_1289	COG1914	H( )-stimulated, divalent metal cation uptake system
BSM4216_1291	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSM4216_1293	COG0463	Glycosyl transferase, family 2
BSM4216_1294	COG2246	polysaccharide biosynthetic process
BSM4216_1295	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSM4216_1297	COG0039	L-malate dehydrogenase activity
BSM4216_1300	COG2135	peptidase activity
BSM4216_1302	COG1937	Protein conserved in bacteria
BSM4216_1304	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BSM4216_1305	COG0720	synthase
BSM4216_1306	COG0602	queuosine metabolic process
BSM4216_1307	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BSM4216_1312	COG3328	transposase activity
BSM4216_1314	COG1473	amidohydrolase
BSM4216_1316	COG4948	Mandelate Racemase Muconate Lactonizing
BSM4216_1320	COG3764	Sortase (surface protein transpeptidase)
BSM4216_1328	COG3383	formate dehydrogenase (NAD+) activity
BSM4216_1333	COG0753	catalase activity
BSM4216_1334	COG1126	abc transporter atp-binding protein
BSM4216_1335	COG0765	amino acid transport
BSM4216_1336	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_1339	COG0626	cystathionine gamma-synthase activity
BSM4216_1340	COG0626	cystathionine gamma-synthase activity
BSM4216_1341	COG2261	transglycosylase associated protein
BSM4216_1342	COG1363	Peptidase, m42
BSM4216_1344	COG2233	PERMEase
BSM4216_1345	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BSM4216_1348	COG0861	Integral membrane protein TerC family
BSM4216_1353	COG1032	radical SAM domain protein
BSM4216_1354	COG3594	Acyltransferase
BSM4216_1355	COG5002	protein histidine kinase activity
BSM4216_1356	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSM4216_1358	COG3852	Histidine kinase
BSM4216_1361	COG1846	Transcriptional regulator
BSM4216_1362	COG0542	response to heat
BSM4216_1363	COG3949	Membrane
BSM4216_1366	COG4873	Protein conserved in bacteria
BSM4216_1372	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BSM4216_1373	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_1374	COG2084	Dehydrogenase
BSM4216_1375	COG0436	Aminotransferase
BSM4216_1376	COG0598	Magnesium transport protein CorA
BSM4216_1377	COG0784	Response regulator, receiver
BSM4216_1377	COG0835	chemotaxis
BSM4216_1381	COG0156	8-amino-7-oxononanoate synthase activity
BSM4216_1382	COG0596	Alpha beta hydrolase
BSM4216_1384	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_1385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_1386	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_1387	COG1116	anion transmembrane transporter activity
BSM4216_1388	COG0431	NADPH-dependent FMN reductase
BSM4216_1389	COG2855	membrane
BSM4216_1391	COG1408	metallophosphoesterase
BSM4216_1394	COG2200	EAL domain
BSM4216_1396	COG4703	Protein of unknown function (DUF1797)
BSM4216_1398	COG0517	IMP dehydrogenase activity
BSM4216_1399	COG2814	Major facilitator Superfamily
BSM4216_1400	COG0583	DNA-binding transcription factor activity
BSM4216_1401	COG2171	N-acyltransferase activity
BSM4216_1402	COG1473	amidohydrolase
BSM4216_1405	COG0450	alkyl hydroperoxide reductase
BSM4216_1406	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_1408	COG1271	oxidase subunit
BSM4216_1409	COG1294	oxidase, subunit
BSM4216_1410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BSM4216_1412	COG0561	phosphatase activity
BSM4216_1421	COG1982	Orn Lys Arg decarboxylase major
BSM4216_1423	COG4476	Belongs to the UPF0223 family
BSM4216_1424	COG4493	Belongs to the UPF0637 family
BSM4216_1428	COG0483	inositol monophosphate 1-phosphatase activity
BSM4216_1433	COG4896	Protein conserved in bacteria
BSM4216_1437	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BSM4216_1439	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BSM4216_1440	COG4838	Belongs to the UPF0358 family
BSM4216_1441	COG0772	Belongs to the SEDS family
BSM4216_1443	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BSM4216_1444	COG1612	heme a metabolic process
BSM4216_1445	COG0109	protoheme IX farnesyltransferase activity
BSM4216_1451	COG3336	cytochrome c oxidase
BSM4216_1455	COG2340	Cysteine-rich secretory protein family
BSM4216_1456	COG2050	protein possibly involved in aromatic compounds catabolism
BSM4216_1461	COG3679	Belongs to the UPF0342 family
BSM4216_1464	COG0742	ribosomal rna small subunit methyltransferase
BSM4216_1465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BSM4216_1466	COG3314	Sporulation integral membrane protein YlbJ
BSM4216_1467	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSM4216_1468	COG3480	Lon protease (S16) C-terminal proteolytic domain
BSM4216_1470	COG1323	Belongs to the UPF0348 family
BSM4216_1471	COG1399	metal-binding, possibly nucleic acid-binding protein
BSM4216_1472	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BSM4216_1474	COG0454	-acetyltransferase
BSM4216_1475	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BSM4216_1476	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
BSM4216_1479	COG0275	rRNA processing
BSM4216_1480	COG4839	cell division protein FtsL
BSM4216_1482	COG0768	penicillin binding
BSM4216_1483	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BSM4216_1485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BSM4216_1486	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BSM4216_1487	COG0772	Belongs to the SEDS family
BSM4216_1489	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BSM4216_1490	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BSM4216_1491	COG0849	cell division
BSM4216_1492	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BSM4216_1494	COG1191	sigma factor activity
BSM4216_1495	COG1191	sigma factor activity
BSM4216_1496	COG1873	PFAM PRC-barrel domain
BSM4216_1498	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BSM4216_1499	COG1799	cell septum assembly
BSM4216_1500	COG0762	integral membrane protein
BSM4216_1501	COG2302	S4 RNA-binding domain
BSM4216_1502	COG3599	regulation of cell shape
BSM4216_1504	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BSM4216_1506	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BSM4216_1507	COG0564	pseudouridine synthase activity
BSM4216_1509	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BSM4216_1512	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BSM4216_1516	COG0167	dihydroorotate dehydrogenase activity
BSM4216_1517	COG0284	orotidine-5'-phosphate decarboxylase activity
BSM4216_1520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
BSM4216_1521	COG1561	YicC-like family, N-terminal region
BSM4216_1523	COG0194	GDP metabolic process
BSM4216_1525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSM4216_1526	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BSM4216_1527	COG0242	peptide deformylase activity
BSM4216_1528	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BSM4216_1529	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSM4216_1529	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSM4216_1531	COG0631	protein serine/threonine phosphatase activity
BSM4216_1532	COG0515	serine threonine protein kinase
BSM4216_1532	COG2815	serine threonine protein kinase
BSM4216_1533	COG1162	GTPase activity
BSM4216_1534	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BSM4216_1535	COG1564	THIamine pyrophosphokinase
BSM4216_1536	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BSM4216_1538	COG1302	Protein conserved in bacteria
BSM4216_1539	COG1461	Dihydroxyacetone kinase
BSM4216_1541	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BSM4216_1542	COG1349	DNA-binding transcription factor activity
BSM4216_1543	COG0416	fatty acid biosynthetic process
BSM4216_1544	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BSM4216_1545	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_1546	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BSM4216_1547	COG0571	ribonuclease III activity
BSM4216_1548	COG1196	nuclear chromosome segregation
BSM4216_1549	COG0552	protein localization to endoplasmic reticulum
BSM4216_1551	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
BSM4216_1552	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BSM4216_1553	COG0228	four-way junction DNA binding
BSM4216_1556	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BSM4216_1557	COG0336	Belongs to the RNA methyltransferase TrmD family
BSM4216_1558	COG0335	large ribosomal subunit rRNA binding
BSM4216_1561	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSM4216_1565	COG2257	FlhB HrpN YscU SpaS Family
BSM4216_1567	COG0045	succinate-CoA ligase (ADP-forming) activity
BSM4216_1568	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BSM4216_1569	COG0758	DNA mediated transformation
BSM4216_1570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BSM4216_1572	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BSM4216_1573	COG4974	Belongs to the 'phage' integrase family
BSM4216_1574	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BSM4216_1575	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BSM4216_1576	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
BSM4216_1578	COG1815	bacterial-type flagellum-dependent cell motility
BSM4216_1579	COG1558	bacterial-type flagellum-dependent cell motility
BSM4216_1580	COG1677	Flagellar hook-basal body complex protein FliE
BSM4216_1581	COG1766	The M ring may be actively involved in energy transduction
BSM4216_1582	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSM4216_1584	COG1157	protein secretion by the type III secretion system
BSM4216_1585	COG2882	bacterial-type flagellum organization
BSM4216_1588	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BSM4216_1589	COG4786	Flagellar basal body rod
BSM4216_1590	COG1582	Flagellar protein (FlbD)
BSM4216_1591	COG1580	Controls the rotational direction of flagella during chemotaxis
BSM4216_1592	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSM4216_1593	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BSM4216_1593	COG1776	CheC inhibitor of MCP methylation
BSM4216_1594	COG2201	protein-glutamate methylesterase activity
BSM4216_1595	COG3190	flagellar
BSM4216_1596	COG1338	Plays a role in the flagellum-specific transport system
BSM4216_1597	COG1987	bacterial-type flagellum assembly
BSM4216_1598	COG1684	flagellar biosynthetic protein fliR
BSM4216_1599	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSM4216_1600	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BSM4216_1601	COG1419	protein localization to endoplasmic reticulum
BSM4216_1602	COG0455	bacterial-type flagellum organization
BSM4216_1603	COG2201	protein-glutamate methylesterase activity
BSM4216_1604	COG0643	Histidine kinase
BSM4216_1604	COG2198	Histidine kinase
BSM4216_1605	COG0835	chemotaxis
BSM4216_1606	COG1776	CheC inhibitor of MCP methylation
BSM4216_1607	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BSM4216_1608	COG1191	sigma factor activity
BSM4216_1610	COG0052	Belongs to the universal ribosomal protein uS2 family
BSM4216_1611	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BSM4216_1612	COG0528	UMP kinase activity
BSM4216_1613	COG0233	cytoplasmic translational termination
BSM4216_1615	COG4589	Belongs to the CDS family
BSM4216_1616	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BSM4216_1617	COG0750	zinc metalloprotease
BSM4216_1619	COG0442	prolyl-tRNA aminoacylation
BSM4216_1620	COG2176	DNA-directed DNA polymerase activity
BSM4216_1621	COG0779	Required for maturation of 30S ribosomal subunits
BSM4216_1622	COG0195	Participates in both transcription termination and antitermination
BSM4216_1623	COG2740	Nucleic-acid-binding protein implicated in transcription termination
BSM4216_1624	COG1358	cellular component organization or biogenesis
BSM4216_1625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BSM4216_1626	COG1550	Protein conserved in bacteria
BSM4216_1627	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BSM4216_1628	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BSM4216_1629	COG0196	riboflavin kinase activity
BSM4216_1630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BSM4216_1631	COG1185	polyribonucleotide nucleotidyltransferase activity
BSM4216_1632	COG0726	polysaccharide deacetylase
BSM4216_1633	COG0612	Peptidase, M16
BSM4216_1634	COG1268	BioY protein
BSM4216_1635	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BSM4216_1638	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_1641	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BSM4216_1643	COG0303	'Molybdopterin
BSM4216_1644	COG1763	Mo-molybdopterin cofactor biosynthetic process
BSM4216_1649	COG1346	cytolysis
BSM4216_1653	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_1655	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSM4216_1661	COG2045	Belongs to the ComB family
BSM4216_1662	COG1024	Enoyl-CoA hydratase
BSM4216_1663	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_1665	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_1666	COG4191	Histidine kinase
BSM4216_1667	COG1960	acyl-CoA dehydrogenase activity
BSM4216_1668	COG0071	Belongs to the small heat shock protein (HSP20) family
BSM4216_1670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BSM4216_1672	COG2223	nitrite transmembrane transporter activity
BSM4216_1673	COG2391	methyltransferase activity
BSM4216_1675	COG4637	Psort location Cytoplasmic, score
BSM4216_1676	COG2814	Major facilitator Superfamily
BSM4216_1678	COG1272	protein, Hemolysin III
BSM4216_1680	COG0024	Methionine aminopeptidase
BSM4216_1684	COG0531	amino acid
BSM4216_1688	COG0723	plastoquinol--plastocyanin reductase activity
BSM4216_1688	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BSM4216_1697	COG0295	cytidine deaminase activity
BSM4216_1699	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BSM4216_1700	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
BSM4216_1709	COG5337	Spore coat protein CotH
BSM4216_1713	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSM4216_1714	COG1733	regulation of RNA biosynthetic process
BSM4216_1720	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BSM4216_1722	COG1113	amino acid transport
BSM4216_1723	COG1280	lysine exporter protein (LysE YggA)
BSM4216_1727	COG0243	molybdopterin cofactor binding
BSM4216_1729	COG1587	Uroporphyrinogen-III synthase
BSM4216_1732	COG3328	transposase activity
BSM4216_1733	COG0477	Major facilitator Superfamily
BSM4216_1735	COG0534	Mate efflux family protein
BSM4216_1739	COG0840	transmembrane signaling receptor activity
BSM4216_1739	COG3290	protein histidine kinase activity
BSM4216_1741	COG2427	Protein of unknown function (DUF1641)
BSM4216_1742	COG3383	formate dehydrogenase (NAD+) activity
BSM4216_1743	COG5609	conserved protein (DUF2294)
BSM4216_1745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BSM4216_1746	COG2116	formate transmembrane transporter activity
BSM4216_1748	COG3773	Cell wall hydrolase
BSM4216_1750	COG0708	Exodeoxyribonuclease III
BSM4216_1751	COG1741	Belongs to the pirin family
BSM4216_1753	COG2066	Belongs to the glutaminase family
BSM4216_1756	COG2070	2-Nitropropane dioxygenase
BSM4216_1758	COG1122	ATPase activity
BSM4216_1761	COG0640	Transcriptional regulator
BSM4216_1762	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BSM4216_1763	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BSM4216_1765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BSM4216_1766	COG0384	phenazine biosynthesis protein PhzF
BSM4216_1767	COG1279	arginine transmembrane transporter activity
BSM4216_1768	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSM4216_1770	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSM4216_1772	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BSM4216_1773	COG1937	Protein conserved in bacteria
BSM4216_1774	COG2217	Heavy metal translocating P-type atpase
BSM4216_1777	COG0702	epimerase
BSM4216_1779	COG1960	acyl-CoA dehydrogenase activity
BSM4216_1785	COG2267	carboxylic ester hydrolase activity
BSM4216_1787	COG3832	glyoxalase III activity
BSM4216_1788	COG0640	Transcriptional regulator
BSM4216_1789	COG3290	protein histidine kinase activity
BSM4216_1789	COG0840	transmembrane signaling receptor activity
BSM4216_1791	COG2226	methyltransferase
BSM4216_1792	COG1854	S-ribosylhomocysteine lyase activity
BSM4216_1793	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSM4216_1794	COG0626	cystathionine gamma-synthase activity
BSM4216_1797	COG1129	ABC transporter
BSM4216_1798	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSM4216_1799	COG1879	ABC-type sugar transport system periplasmic component
BSM4216_1800	COG1609	Transcriptional regulator
BSM4216_1801	COG0673	inositol 2-dehydrogenase activity
BSM4216_1804	COG3962	Belongs to the TPP enzyme family
BSM4216_1805	COG1082	Xylose isomerase domain protein TIM barrel
BSM4216_1806	COG3718	enzyme involved in inositol metabolism
BSM4216_1807	COG2814	Major facilitator Superfamily
BSM4216_1808	COG0673	inositol 2-dehydrogenase activity
BSM4216_1812	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_1813	COG2030	dehydratase
BSM4216_1816	COG0456	acetyltransferase
BSM4216_1835	COG1011	Hydrolase
BSM4216_1839	COG0444	Belongs to the ABC transporter superfamily
BSM4216_1840	COG4608	Belongs to the ABC transporter superfamily
BSM4216_1842	COG1464	Belongs to the NlpA lipoprotein family
BSM4216_1844	COG2011	ABC-type metal ion transport system permease component
BSM4216_1845	COG1464	Belongs to the NlpA lipoprotein family
BSM4216_1851	COG3328	transposase activity
BSM4216_1852	COG0454	-acetyltransferase
BSM4216_1867	COG0697	spore germination
BSM4216_1875	COG1607	acyl-coa hydrolase
BSM4216_1876	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BSM4216_1877	COG0531	amino acid
BSM4216_1878	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSM4216_1881	COG2376	Dihydroxyacetone kinase
BSM4216_1882	COG1461	Dihydroxyacetone kinase
BSM4216_1883	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
BSM4216_1884	COG1113	amino acid transport
BSM4216_1886	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BSM4216_1889	COG0745	RESPONSE REGULATOR receiver
BSM4216_1890	COG2205	protein histidine kinase activity
BSM4216_1891	COG1136	(ABC) transporter
BSM4216_1892	COG0577	efflux transmembrane transporter activity
BSM4216_1900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSM4216_1907	COG0488	(ABC) transporter
BSM4216_1908	COG0583	DNA-binding transcription factor activity
BSM4216_1909	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_1913	COG4372	Transposase
BSM4216_1915	COG1611	Belongs to the LOG family
BSM4216_1919	COG0515	serine threonine protein kinase
BSM4216_1920	COG2267	carboxylic ester hydrolase activity
BSM4216_1921	COG0730	response to heat
BSM4216_1922	COG1648	precorrin-2 dehydrogenase activity
BSM4216_1922	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BSM4216_1926	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BSM4216_1927	COG0529	Catalyzes the synthesis of activated sulfate
BSM4216_1928	COG2046	Belongs to the sulfate adenylyltransferase family
BSM4216_1929	COG0175	sulfate reduction
BSM4216_1932	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BSM4216_1933	COG0187	DNA topoisomerase II activity
BSM4216_1934	COG1832	CoA-binding protein
BSM4216_1936	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BSM4216_1938	COG4841	protein insertion into membrane
BSM4216_1944	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_1945	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BSM4216_1948	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_1960	COG0686	Belongs to the AlaDH PNT family
BSM4216_1962	COG1999	signal sequence binding
BSM4216_1964	COG0419	ATPase involved in DNA repair
BSM4216_1965	COG0420	3'-5' exonuclease activity
BSM4216_1967	COG4846	Membrane protein involved in cytochrome C biogenesis
BSM4216_1970	COG0785	Cytochrome C biogenesis protein
BSM4216_1971	COG0583	DNA-binding transcription factor activity
BSM4216_1973	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSM4216_1974	COG3763	UPF0154 protein
BSM4216_1978	COG4224	UPF0291 protein
BSM4216_1979	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BSM4216_1981	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BSM4216_1985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_1986	COG0640	Transcriptional regulator
BSM4216_1990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BSM4216_1991	COG2169	Transcriptional regulator
BSM4216_1992	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BSM4216_1997	COG2333	competence protein COMEC
BSM4216_1997	COG0658	competence protein
BSM4216_2001	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSM4216_2002	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BSM4216_2010	COG3328	transposase activity
BSM4216_2011	COG0174	glutamine synthetase
BSM4216_2012	COG0789	Transcriptional regulator
BSM4216_2013	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
BSM4216_2014	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BSM4216_2016	COG0464	growth
BSM4216_2017	COG1923	regulation of RNA biosynthetic process
BSM4216_2018	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BSM4216_2025	COG3328	transposase activity
BSM4216_2029	COG1376	ErfK ybiS ycfS ynhG family protein
BSM4216_2031	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BSM4216_2032	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BSM4216_2035	COG4550	Control of competence regulator ComK, YlbF/YmcA
BSM4216_2036	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSM4216_2037	COG1013	pyruvate-flavodoxin oxidoreductase activity
BSM4216_2038	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BSM4216_2038	COG0674	pyruvate-flavodoxin oxidoreductase activity
BSM4216_2040	COG2359	stage V sporulation protein S
BSM4216_2041	COG1692	metallophosphoesterase
BSM4216_2042	COG1418	mRNA catabolic process
BSM4216_2044	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BSM4216_2048	COG1058	Belongs to the CinA family
BSM4216_2048	COG1546	Belongs to the CinA family
BSM4216_2049	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BSM4216_2050	COG1426	Protein conserved in bacteria
BSM4216_2053	COG0300	oxidoreductase activity
BSM4216_2054	COG0612	Peptidase, M16
BSM4216_2055	COG0612	Peptidase, M16
BSM4216_2056	COG1674	ftsk spoiiie
BSM4216_2056	COG4980	gas vesicle protein
BSM4216_2058	COG0740	serine-type endopeptidase activity
BSM4216_2063	COG0527	aspartate kinase activity
BSM4216_2064	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BSM4216_2065	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BSM4216_2066	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BSM4216_2067	COG1873	PFAM PRC-barrel domain
BSM4216_2073	COG0706	membrane insertase activity
BSM4216_2077	COG1114	Component of the transport system for branched-chain amino acids
BSM4216_2080	COG4548	von Willebrand factor, type A
BSM4216_2081	COG0714	Associated with various cellular activities
BSM4216_2091	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BSM4216_2094	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSM4216_2095	COG0567	Dehydrogenase, E1 component
BSM4216_2097	COG1119	ATPase activity
BSM4216_2098	COG1295	ribonuclease BN
BSM4216_2104	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BSM4216_2104	COG0512	Glutamine amidotransferase of anthranilate synthase
BSM4216_2105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BSM4216_2109	COG0083	homoserine kinase activity
BSM4216_2110	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BSM4216_2111	COG0460	homoserine dehydrogenase
BSM4216_2116	COG1331	Highly conserved protein containing a thioredoxin domain
BSM4216_2118	COG4372	Transposase
BSM4216_2122	COG0840	transmembrane signaling receptor activity
BSM4216_2124	COG0840	transmembrane signaling receptor activity
BSM4216_2126	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BSM4216_2127	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BSM4216_2128	COG0438	transferase activity, transferring glycosyl groups
BSM4216_2129	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSM4216_2131	COG0456	acetyltransferase
BSM4216_2136	COG2814	Major facilitator Superfamily
BSM4216_2137	COG1070	Carbohydrate kinase
BSM4216_2138	COG2115	Belongs to the xylose isomerase family
BSM4216_2140	COG2017	converts alpha-aldose to the beta-anomer
BSM4216_2141	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BSM4216_2142	COG1953	Uracil, thiamine, allantoin
BSM4216_2143	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSM4216_2145	COG2508	Transcriptional regulator
BSM4216_2146	COG2233	PERMEase
BSM4216_2148	COG2351	hydroxyisourate hydrolase activity
BSM4216_2149	COG2080	2 iron, 2 sulfur cluster binding
BSM4216_2150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BSM4216_2151	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
BSM4216_2152	COG0402	S-adenosylhomocysteine deaminase activity
BSM4216_2156	COG2226	methyltransferase
BSM4216_2157	COG1378	Sugar-specific transcriptional regulator TrmB
BSM4216_2159	COG0579	oxidoreductase
BSM4216_2160	COG2186	Transcriptional regulator
BSM4216_2161	COG0277	FAD linked oxidase domain protein
BSM4216_2162	COG0247	lactate metabolic process
BSM4216_2175	COG0656	L-ascorbic acid biosynthetic process
BSM4216_2177	COG2368	4-hydroxyphenylacetate
BSM4216_2179	COG2848	UPF0210 protein
BSM4216_2180	COG3830	Belongs to the UPF0237 family
BSM4216_2181	COG0765	amino acid transport
BSM4216_2182	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_2183	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_2186	COG2966	Psort location CytoplasmicMembrane, score
BSM4216_2187	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BSM4216_2189	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BSM4216_2190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BSM4216_2191	COG2329	Antibiotic biosynthesis monooxygenase
BSM4216_2194	COG0351	phosphomethylpyrimidine kinase
BSM4216_2196	COG0671	phosphoesterase, PA-phosphatase related
BSM4216_2197	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
BSM4216_2198	COG3285	dna ligase
BSM4216_2198	COG1793	dna ligase
BSM4216_2199	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BSM4216_2200	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BSM4216_2201	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSM4216_2201	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BSM4216_2202	COG0307	riboflavin synthase, alpha
BSM4216_2203	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSM4216_2203	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BSM4216_2208	COG0586	Pfam SNARE associated Golgi protein
BSM4216_2212	COG0534	Mate efflux family protein
BSM4216_2213	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_2214	COG2340	Cysteine-rich secretory protein family
BSM4216_2216	COG1846	Transcriptional regulator
BSM4216_2217	COG3409	Peptidoglycan-binding domain 1 protein
BSM4216_2217	COG0793	Belongs to the peptidase S41A family
BSM4216_2220	COG1876	peptidase activity
BSM4216_2221	COG0813	purine-nucleoside phosphorylase activity
BSM4216_2225	COG4326	sporulation control protein
BSM4216_2231	COG4479	Belongs to the UPF0346 family
BSM4216_2232	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
BSM4216_2235	COG2190	(PTS) system
BSM4216_2236	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSM4216_2237	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BSM4216_2239	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BSM4216_2239	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
BSM4216_2244	COG2755	lipolytic protein G-D-S-L family
BSM4216_2249	COG1125	glycine betaine transport
BSM4216_2249	COG0517	IMP dehydrogenase activity
BSM4216_2253	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BSM4216_2257	COG0166	Belongs to the GPI family
BSM4216_2258	COG0861	Integral membrane protein TerC family
BSM4216_2260	COG1413	lyase activity
BSM4216_2261	COG0488	(ABC) transporter
BSM4216_2265	COG2226	methyltransferase
BSM4216_2267	COG1321	iron dependent repressor
BSM4216_2268	COG1278	Cold shock
BSM4216_2270	COG0328	RNA-DNA hybrid ribonuclease activity
BSM4216_2272	COG0697	spore germination
BSM4216_2275	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSM4216_2277	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSM4216_2281	COG3424	synthase
BSM4216_2282	COG2233	PERMEase
BSM4216_2283	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSM4216_2285	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BSM4216_2287	COG0116	Belongs to the methyltransferase superfamily
BSM4216_2292	COG3359	exonuclease
BSM4216_2293	COG1111	helicase
BSM4216_2293	COG1205	dead DEAH box helicase
BSM4216_2302	COG3331	DNA recombination
BSM4216_2303	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_2303	COG4499	WXG100 protein secretion system (Wss), protein YukC
BSM4216_2305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BSM4216_2306	COG3935	DnaD domain protein
BSM4216_2307	COG0017	Asparaginyl-tRNA synthetase
BSM4216_2308	COG5353	protein conserved in bacteria
BSM4216_2311	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BSM4216_2311	COG1199	ATP-dependent helicase activity
BSM4216_2312	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BSM4216_2313	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BSM4216_2314	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BSM4216_2316	COG0617	tRNA 3'-terminal CCA addition
BSM4216_2317	COG0438	transferase activity, transferring glycosyl groups
BSM4216_2319	COG1803	Methylglyoxal synthase
BSM4216_2320	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BSM4216_2321	COG1694	Mazg nucleotide pyrophosphohydrolase
BSM4216_2322	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BSM4216_2323	COG2738	Putative neutral zinc metallopeptidase
BSM4216_2325	COG4347	Protein of unknown function (DUF1405)
BSM4216_2326	COG2010	Cytochrome c
BSM4216_2326	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSM4216_2327	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BSM4216_2331	COG0457	Tetratricopeptide repeat
BSM4216_2333	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BSM4216_2334	COG0287	Prephenate dehydrogenase
BSM4216_2335	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BSM4216_2336	COG4401	Chorismate mutase type I
BSM4216_2338	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BSM4216_2339	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BSM4216_2340	COG0105	UTP biosynthetic process
BSM4216_2341	COG0142	geranyltranstransferase activity
BSM4216_2342	COG2226	methyltransferase
BSM4216_2343	COG0142	geranyltranstransferase activity
BSM4216_2346	COG0302	gtp cyclohydrolase
BSM4216_2347	COG0776	regulation of translation
BSM4216_2348	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
BSM4216_2354	COG1160	GTP binding
BSM4216_2361	COG0539	negative regulation of cytoplasmic translation
BSM4216_2362	COG0204	Acyl-transferase
BSM4216_2363	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BSM4216_2367	COG2959	enzyme of heme biosynthesis
BSM4216_2368	COG3773	Cell wall hydrolase
BSM4216_2368	COG3409	Peptidoglycan-binding domain 1 protein
BSM4216_2369	COG2339	peptidase activity
BSM4216_2370	COG0252	asparaginase activity
BSM4216_2371	COG0517	IMP dehydrogenase activity
BSM4216_2374	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_2377	COG4862	establishment of competence for transformation
BSM4216_2378	COG0789	Transcriptional regulator
BSM4216_2380	COG0531	amino acid
BSM4216_2381	COG4302	ethanolamine ammonia-lyase activity
BSM4216_2382	COG4303	Ethanolamine ammonia lyase large subunit
BSM4216_2387	COG3546	catalase activity
BSM4216_2389	COG1388	LysM domain
BSM4216_2390	COG1266	CAAX protease self-immunity
BSM4216_2391	COG0514	ATP-dependent DNA helicase (RecQ)
BSM4216_2392	COG4955	Helix-turn-helix domain
BSM4216_2393	COG1141	Ferredoxin
BSM4216_2394	COG0840	transmembrane signaling receptor activity
BSM4216_2399	COG5002	protein histidine kinase activity
BSM4216_2400	COG0745	RESPONSE REGULATOR receiver
BSM4216_2402	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSM4216_2403	COG1333	cytochrome c biogenesis protein
BSM4216_2404	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_2406	COG1187	pseudouridine synthase activity
BSM4216_2407	COG0700	Nucleoside recognition
BSM4216_2408	COG2715	membrane protein required for spore maturation
BSM4216_2409	COG1686	Belongs to the peptidase S11 family
BSM4216_2411	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BSM4216_2412	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BSM4216_2413	COG1547	Domain of unknown function (DUF309)
BSM4216_2416	COG0697	spore germination
BSM4216_2420	COG2172	sigma factor antagonist activity
BSM4216_2427	COG4974	Belongs to the 'phage' integrase family
BSM4216_2429	COG0735	belongs to the Fur family
BSM4216_2432	COG1300	Membrane
BSM4216_2436	COG0667	Aldo Keto reductase
BSM4216_2438	COG1073	alpha beta
BSM4216_2442	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSM4216_2445	COG0300	oxidoreductase activity
BSM4216_2448	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSM4216_2449	COG1902	pentaerythritol trinitrate reductase activity
BSM4216_2450	COG1234	tRNA 3'-trailer cleavage
BSM4216_2451	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BSM4216_2453	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BSM4216_2456	COG0351	phosphomethylpyrimidine kinase
BSM4216_2457	COG0561	phosphatase activity
BSM4216_2460	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_2460	COG1263	PTS System
BSM4216_2461	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BSM4216_2462	COG1737	Transcriptional regulator
BSM4216_2463	COG1132	(ABC) transporter
BSM4216_2468	COG1953	Uracil, thiamine, allantoin
BSM4216_2470	COG1454	alcohol dehydrogenase
BSM4216_2471	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BSM4216_2473	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BSM4216_2475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BSM4216_2476	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BSM4216_2477	COG1960	acyl-CoA dehydrogenase activity
BSM4216_2478	COG0835	chemotaxis
BSM4216_2478	COG0784	Response regulator, receiver
BSM4216_2479	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSM4216_2482	COG1376	ErfK ybiS ycfS ynhG family protein
BSM4216_2483	COG4129	membrane
BSM4216_2487	COG4086	secreted protein
BSM4216_2488	COG0508	dehydrogenase complex catalyzes the overall conversion of
BSM4216_2489	COG0022	dehydrogenase e1 component
BSM4216_2490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BSM4216_2491	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BSM4216_2494	COG3290	protein histidine kinase activity
BSM4216_2494	COG3829	transcription factor binding
BSM4216_2498	COG0584	glycerophosphoryl diester phosphodiesterase
BSM4216_2499	COG0745	RESPONSE REGULATOR receiver
BSM4216_2500	COG0750	zinc metalloprotease
BSM4216_2501	COG0497	DNA recombination
BSM4216_2503	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BSM4216_2504	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BSM4216_2507	COG1722	exodeoxyribonuclease VII activity
BSM4216_2509	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BSM4216_2510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BSM4216_2511	COG1302	Protein conserved in bacteria
BSM4216_2512	COG0439	Biotin carboxylase
BSM4216_2513	COG0511	ligase activity, forming carbon-carbon bonds
BSM4216_2522	COG3854	ATPases associated with a variety of cellular activities
BSM4216_2523	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BSM4216_2524	COG0006	proline dipeptidase activity
BSM4216_2525	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BSM4216_2527	COG3872	metal-dependent enzyme
BSM4216_2529	COG1752	Esterase of the alpha-beta hydrolase superfamily
BSM4216_2530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSM4216_2532	COG0095	Lipoate-protein ligase
BSM4216_2533	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSM4216_2535	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSM4216_2536	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BSM4216_2537	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BSM4216_2539	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSM4216_2542	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BSM4216_2547	COG4537	Required for transformation and DNA binding
BSM4216_2548	COG1459	type II secretion system
BSM4216_2549	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BSM4216_2550	COG0737	Belongs to the 5'-nucleotidase family
BSM4216_2553	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BSM4216_2557	COG1368	sulfuric ester hydrolase activity
BSM4216_2558	COG1940	carbohydrate kinase activity
BSM4216_2559	COG4483	Protein conserved in bacteria
BSM4216_2561	COG0705	Rhomboid family
BSM4216_2561	COG0457	Tetratricopeptide repeat
BSM4216_2564	COG1836	PFAM Integral membrane protein DUF92
BSM4216_2565	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BSM4216_2568	COG0438	transferase activity, transferring glycosyl groups
BSM4216_2583	COG2839	Protein conserved in bacteria
BSM4216_2585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BSM4216_2586	COG4709	membrane
BSM4216_2588	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
BSM4216_2589	COG0735	belongs to the Fur family
BSM4216_2592	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BSM4216_2596	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BSM4216_2597	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BSM4216_2598	COG2384	SAM-dependent methyltransferase
BSM4216_2599	COG2010	Cytochrome c
BSM4216_2602	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BSM4216_2603	COG0358	DNA primase activity
BSM4216_2604	COG1671	Belongs to the UPF0178 family
BSM4216_2605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BSM4216_2606	COG0517	IMP dehydrogenase activity
BSM4216_2607	COG0751	glycine-tRNA ligase activity
BSM4216_2608	COG0752	glycyl-tRNA synthetase alpha subunit
BSM4216_2609	COG1381	Involved in DNA repair and RecF pathway recombination
BSM4216_2613	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BSM4216_2615	COG1480	7TM receptor with intracellular HD hydrolase
BSM4216_2616	COG1702	phosphate starvation-inducible protein PhoH
BSM4216_2620	COG4864	UPF0365 protein
BSM4216_2621	COG1030	water channel activity
BSM4216_2624	COG1610	YqeY-like protein
BSM4216_2625	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BSM4216_2626	COG0697	spore germination
BSM4216_2627	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BSM4216_2628	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BSM4216_2629	COG2264	protein methyltransferase activity
BSM4216_2630	COG0484	heat shock protein binding
BSM4216_2631	COG0443	Heat shock 70 kDa protein
BSM4216_2632	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BSM4216_2634	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BSM4216_2636	COG0481	GTPase activity
BSM4216_2638	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_2640	COG0268	Binds directly to 16S ribosomal RNA
BSM4216_2642	COG1466	dna polymerase III delta subunit
BSM4216_2644	COG2333	competence protein COMEC
BSM4216_2644	COG0658	competence protein
BSM4216_2645	COG2131	deaminase
BSM4216_2646	COG1596	polysaccharide export
BSM4216_2646	COG1555	photosystem II stabilization
BSM4216_2647	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BSM4216_2648	COG2226	methyltransferase
BSM4216_2649	COG0799	negative regulation of ribosome biogenesis
BSM4216_2650	COG1713	HD superfamily hydrolase involved in NAD metabolism
BSM4216_2651	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BSM4216_2652	COG1534	Rna-binding protein
BSM4216_2654	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BSM4216_2655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
BSM4216_2663	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BSM4216_2665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BSM4216_2666	COG0572	uridine kinase
BSM4216_2671	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BSM4216_2672	COG3906	Belongs to the UPF0473 family
BSM4216_2673	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BSM4216_2674	COG4472	Bacterial protein of unknown function (DUF965)
BSM4216_2675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BSM4216_2678	COG0628	permease
BSM4216_2682	COG3881	PFAM PRC-barrel domain
BSM4216_2683	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BSM4216_2686	COG0482	sulfurtransferase activity
BSM4216_2687	COG1104	cysteine desulfurase activity
BSM4216_2688	COG1959	2 iron, 2 sulfur cluster binding
BSM4216_2689	COG2364	Membrane
BSM4216_2690	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BSM4216_2693	COG0477	Major facilitator Superfamily
BSM4216_2695	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BSM4216_2696	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BSM4216_2697	COG0124	histidyl-tRNA synthetase
BSM4216_2699	COG3103	Sh3 type 3 domain protein
BSM4216_2699	COG4991	sh3 domain protein
BSM4216_2699	COG0860	N-Acetylmuramoyl-L-alanine amidase
BSM4216_2700	COG1490	D-aminoacyl-tRNA deacylase activity
BSM4216_2701	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BSM4216_2702	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BSM4216_2703	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BSM4216_2703	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BSM4216_2704	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSM4216_2704	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BSM4216_2706	COG2244	polysaccharide biosynthetic process
BSM4216_2709	COG1862	Preprotein translocase
BSM4216_2710	COG0343	queuine tRNA-ribosyltransferase activity
BSM4216_2711	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BSM4216_2722	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
BSM4216_2722	COG0392	lysyltransferase activity
BSM4216_2724	COG0217	transcriptional regulatory protein
BSM4216_2727	COG1388	LysM domain
BSM4216_2729	COG0157	Belongs to the NadC ModD family
BSM4216_2730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BSM4216_2731	COG1104	cysteine desulfurase activity
BSM4216_2732	COG1827	regulation of RNA biosynthetic process
BSM4216_2734	COG0077	Prephenate dehydratase
BSM4216_2735	COG4492	Belongs to the UPF0735 family
BSM4216_2736	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BSM4216_2737	COG3290	protein histidine kinase activity
BSM4216_2738	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BSM4216_2739	COG2868	ribosomal protein
BSM4216_2740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BSM4216_2741	COG1530	ribonuclease E activity
BSM4216_2742	COG1994	Peptidase M50
BSM4216_2744	COG2894	cell division
BSM4216_2745	COG0850	regulation of cytokinetic process
BSM4216_2746	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
BSM4216_2747	COG1792	Involved in formation and maintenance of cell shape
BSM4216_2748	COG1077	Cell shape determining protein MreB Mrl
BSM4216_2749	COG2003	Belongs to the UPF0758 family
BSM4216_2757	COG0285	dihydrofolate synthase activity
BSM4216_2762	COG1301	dicarboxylic acid transport
BSM4216_2764	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSM4216_2765	COG1388	LysM domain
BSM4216_2765	COG1388	LysM domain
BSM4216_2768	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BSM4216_2769	COG0113	porphobilinogen synthase activity
BSM4216_2771	COG0181	hydroxymethylbilane synthase activity
BSM4216_2772	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BSM4216_2775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BSM4216_2776	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BSM4216_2778	COG1067	ATP-dependent peptidase activity
BSM4216_2778	COG0470	DNA polymerase III
BSM4216_2779	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BSM4216_2780	COG0544	peptidyl-prolyl cis-trans isomerase activity
BSM4216_2781	COG0457	Tetratricopeptide repeat
BSM4216_2781	COG1477	protein flavinylation
BSM4216_2788	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BSM4216_2789	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BSM4216_2790	COG5401	PFAM Sporulation and spore germination
BSM4216_2791	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BSM4216_2795	COG1695	Transcriptional regulator
BSM4216_2800	COG2197	response regulator
BSM4216_2802	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BSM4216_2803	COG1053	succinate dehydrogenase
BSM4216_2804	COG2009	succinate dehydrogenase
BSM4216_2805	COG1719	4-vinyl reductase, 4VR
BSM4216_2808	COG0322	excinuclease ABC activity
BSM4216_2810	COG3118	belongs to the thioredoxin family
BSM4216_2812	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BSM4216_2813	COG2086	electron transfer activity
BSM4216_2814	COG1024	Enoyl-CoA hydratase
BSM4216_2815	COG1309	transcriptional regulator
BSM4216_2816	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_2818	COG1193	negative regulation of DNA recombination
BSM4216_2819	COG1796	DNA polymerase
BSM4216_2819	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSM4216_2821	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BSM4216_2823	COG0072	phenylalanine-tRNA ligase activity
BSM4216_2823	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSM4216_2824	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BSM4216_2826	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BSM4216_2828	COG1363	Peptidase, m42
BSM4216_2831	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BSM4216_2834	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BSM4216_2837	COG1484	DNA-dependent DNA replication
BSM4216_2838	COG3611	Membrane attachment protein
BSM4216_2839	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BSM4216_2840	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BSM4216_2841	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BSM4216_2842	COG0237	dephospho-CoA kinase activity
BSM4216_2843	COG1971	Probably functions as a manganese efflux pump
BSM4216_2844	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BSM4216_2845	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSM4216_2845	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BSM4216_2848	COG0745	RESPONSE REGULATOR receiver
BSM4216_2849	COG0039	L-malate dehydrogenase activity
BSM4216_2851	COG0538	isocitrate dehydrogenase activity
BSM4216_2852	COG0372	Belongs to the citrate synthase family
BSM4216_2853	COG2707	UPF0756 membrane protein
BSM4216_2855	COG0628	permease
BSM4216_2859	COG0205	6-phosphofructokinase activity
BSM4216_2860	COG0825	malonyl-CoA metabolic process
BSM4216_2861	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BSM4216_2862	COG1725	Transcriptional regulator
BSM4216_2864	COG0281	malic enzyme
BSM4216_2865	COG0587	DNA-directed DNA polymerase activity
BSM4216_2868	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BSM4216_2870	COG4109	DRTGG domain
BSM4216_2871	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BSM4216_2872	COG0006	proline dipeptidase activity
BSM4216_2875	COG0589	response to stress
BSM4216_2876	COG0165	Argininosuccinate lyase
BSM4216_2877	COG0137	argininosuccinate synthase activity
BSM4216_2879	COG0521	Mo-molybdopterin cofactor biosynthetic process
BSM4216_2881	COG0827	DNA restriction-modification system
BSM4216_2883	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BSM4216_2884	COG3874	Sporulation protein YtfJ
BSM4216_2886	COG1714	RDD family
BSM4216_2887	COG0616	signal peptide processing
BSM4216_2893	COG2962	Rard protein
BSM4216_2894	COG1574	metal-dependent hydrolase with the TIM-barrel fold
BSM4216_2895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSM4216_2897	COG0301	tRNA thio-modification
BSM4216_2898	COG1104	cysteine desulfurase activity
BSM4216_2899	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
BSM4216_2900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BSM4216_2901	COG1309	transcriptional regulator
BSM4216_2902	COG1956	GAF domain-containing protein
BSM4216_2903	COG2203	Gaf domain
BSM4216_2903	COG2199	diguanylate cyclase activity
BSM4216_2905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BSM4216_2909	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BSM4216_2911	COG0454	-acetyltransferase
BSM4216_2912	COG0517	IMP dehydrogenase activity
BSM4216_2913	COG0123	including yeast histone deacetylase and acetoin utilization protein
BSM4216_2915	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
BSM4216_2915	COG1605	Chorismate mutase
BSM4216_2920	COG1028	Short-chain dehydrogenase reductase Sdr
BSM4216_2921	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BSM4216_2923	COG1674	ftsk spoiiie
BSM4216_2924	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BSM4216_2925	COG4848	Belongs to the UPF0354 family
BSM4216_2926	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_2927	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
BSM4216_2928	COG1363	Peptidase, m42
BSM4216_2932	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BSM4216_2934	COG0510	thiamine kinase activity
BSM4216_2936	COG1523	belongs to the glycosyl hydrolase 13 family
BSM4216_2939	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BSM4216_2942	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BSM4216_2943	COG1349	DNA-binding transcription factor activity
BSM4216_2944	COG1187	pseudouridine synthase activity
BSM4216_2945	COG2244	polysaccharide biosynthetic process
BSM4216_2946	COG2081	HI0933 family
BSM4216_2947	COG2081	HI0933 family
BSM4216_2950	COG2059	Chromate
BSM4216_2951	COG2059	Chromate
BSM4216_2952	COG0840	transmembrane signaling receptor activity
BSM4216_2954	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_2955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BSM4216_2956	COG0495	leucyl-tRNA aminoacylation
BSM4216_2960	COG1242	4 iron, 4 sulfur cluster binding
BSM4216_2961	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
BSM4216_2962	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BSM4216_2964	COG2267	carboxylic ester hydrolase activity
BSM4216_2966	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BSM4216_2967	COG4990	cell redox homeostasis
BSM4216_2968	COG0367	asparagine synthase
BSM4216_2970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BSM4216_2972	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BSM4216_2975	COG1506	peptidase
BSM4216_2976	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_2977	COG1116	anion transmembrane transporter activity
BSM4216_2978	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_2979	COG0494	nUDIX hydrolase
BSM4216_2982	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BSM4216_2984	COG0697	spore germination
BSM4216_2987	COG0783	Belongs to the Dps family
BSM4216_2988	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BSM4216_2990	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_2991	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BSM4216_2992	COG0596	Alpha beta hydrolase
BSM4216_2993	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
BSM4216_2994	COG1169	isochorismate synthase
BSM4216_2995	COG1575	Belongs to the MenA family. Type 1 subfamily
BSM4216_2998	COG0058	SHG alpha-glucan phosphorylase activity
BSM4216_2999	COG0297	glycogen (starch) synthase activity
BSM4216_3000	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BSM4216_3026	COG1285	pathogenesis
BSM4216_3030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSM4216_3032	COG2814	Major facilitator Superfamily
BSM4216_3033	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSM4216_3039	COG1979	alcohol dehydrogenase
BSM4216_3040	COG2155	Conserved Protein
BSM4216_3042	COG1012	belongs to the aldehyde dehydrogenase family
BSM4216_3043	COG1098	S1 RNA binding domain
BSM4216_3044	COG0436	Aminotransferase
BSM4216_3045	COG1522	sequence-specific DNA binding
BSM4216_3046	COG2267	carboxylic ester hydrolase activity
BSM4216_3048	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BSM4216_3058	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BSM4216_3065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_3067	COG2050	protein possibly involved in aromatic compounds catabolism
BSM4216_3070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BSM4216_3072	COG3584	3D domain protein
BSM4216_3073	COG1764	response to oxidative stress
BSM4216_3075	COG1252	NADH dehydrogenase
BSM4216_3076	COG0492	ferredoxin-NADP+ reductase activity
BSM4216_3081	COG0316	Belongs to the HesB IscA family
BSM4216_3083	COG4844	belongs to the
BSM4216_3084	COG1252	NADH dehydrogenase
BSM4216_3085	COG4837	Protein of unknown function (DUF1462)
BSM4216_3086	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BSM4216_3087	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BSM4216_3089	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BSM4216_3090	COG0647	UMP catabolic process
BSM4216_3091	COG2445	Protein of unknown function DUF86
BSM4216_3094	COG4470	Protein conserved in bacteria
BSM4216_3098	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BSM4216_3099	COG0739	heme binding
BSM4216_3101	COG0737	Belongs to the 5'-nucleotidase family
BSM4216_3102	COG1801	Protein of unknown function DUF72
BSM4216_3107	COG0719	Fe-S assembly protein
BSM4216_3108	COG0822	iron-sulfur transferase activity
BSM4216_3109	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BSM4216_3110	COG0719	Fe-S assembly protein
BSM4216_3111	COG0396	ATPase activity
BSM4216_3113	COG1464	Belongs to the NlpA lipoprotein family
BSM4216_3114	COG2011	ABC-type metal ion transport system permease component
BSM4216_3115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BSM4216_3119	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BSM4216_3120	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
BSM4216_3121	COG0509	glycine decarboxylation via glycine cleavage system
BSM4216_3122	COG1393	Belongs to the ArsC family
BSM4216_3123	COG1960	acyl-CoA dehydrogenase activity
BSM4216_3124	COG0183	Belongs to the thiolase family
BSM4216_3126	COG3328	transposase activity
BSM4216_3130	COG5577	PFAM Coat F domain
BSM4216_3131	COG1556	Lactate utilization protein
BSM4216_3132	COG1139	Iron-sulfur cluster binding protein
BSM4216_3133	COG0247	lactate metabolic process
BSM4216_3134	COG2186	Transcriptional regulator
BSM4216_3135	COG2814	Major facilitator Superfamily
BSM4216_3136	COG0772	Belongs to the SEDS family
BSM4216_3138	COG0778	Nitroreductase
BSM4216_3145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BSM4216_3146	COG1024	Enoyl-CoA hydratase
BSM4216_3147	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BSM4216_3148	COG0511	ligase activity, forming carbon-carbon bonds
BSM4216_3149	COG0439	Biotin carboxylase
BSM4216_3150	COG0318	PFAM AMP-dependent synthetase and ligase
BSM4216_3151	COG1960	acyl-CoA dehydrogenase activity
BSM4216_3152	COG1309	transcriptional regulator
BSM4216_3153	COG2996	Protein conserved in bacteria
BSM4216_3154	COG1388	LysM domain
BSM4216_3154	COG3858	chitin binding
BSM4216_3156	COG1473	amidohydrolase
BSM4216_3157	COG1619	proteins homologs of microcin C7 resistance protein MccF
BSM4216_3158	COG1742	UPF0060 membrane protein
BSM4216_3159	COG3037	sugar-specific permease SgaT UlaA
BSM4216_3161	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BSM4216_3162	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BSM4216_3163	COG0628	permease
BSM4216_3167	COG2267	carboxylic ester hydrolase activity
BSM4216_3172	COG0765	amino acid transport
BSM4216_3183	COG3344	reverse transcriptase
BSM4216_3185	COG2723	6-phospho-beta-galactosidase activity
BSM4216_3189	COG0531	amino acid
BSM4216_3191	COG3290	protein histidine kinase activity
BSM4216_3191	COG3829	transcription factor binding
BSM4216_3194	COG0442	prolyl-tRNA aminoacylation
BSM4216_3196	COG1309	transcriptional regulator
BSM4216_3200	COG4372	Transposase
BSM4216_3207	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BSM4216_3210	COG1203	CRISPR-associated helicase, Cas3
BSM4216_3217	COG1388	LysM domain
BSM4216_3217	COG0791	NLP P60 protein
BSM4216_3227	COG0840	transmembrane signaling receptor activity
BSM4216_3229	COG5577	PFAM Coat F domain
BSM4216_3234	COG3764	Sortase (surface protein transpeptidase)
BSM4216_3238	COG1595	DNA-templated transcription, initiation
BSM4216_3242	COG0726	polysaccharide deacetylase
BSM4216_3243	COG0586	Pfam SNARE associated Golgi protein
BSM4216_3244	COG2094	Belongs to the DNA glycosylase MPG family
BSM4216_3248	COG0672	)-iron permease
BSM4216_3249	COG2837	iron assimilation
BSM4216_3250	COG2822	iron ion transport
BSM4216_3255	COG0655	NAD(P)H dehydrogenase (quinone) activity
BSM4216_3256	COG2814	Major facilitator Superfamily
BSM4216_3257	COG1566	PFAM secretion protein HlyD family protein
BSM4216_3261	COG1846	Transcriptional regulator
BSM4216_3262	COG3842	ATPase activity
BSM4216_3264	COG0010	Belongs to the arginase family
BSM4216_3267	COG3328	transposase activity
BSM4216_3273	COG0347	Belongs to the P(II) protein family
BSM4216_3274	COG0004	ammonium transporteR
BSM4216_3275	COG0385	Bile acid
BSM4216_3285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BSM4216_3286	COG2089	acid synthase
BSM4216_3288	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
BSM4216_3293	COG1216	Glycosyl transferase, family 2
BSM4216_3298	COG1086	Polysaccharide biosynthesis protein
BSM4216_3299	COG2604	Protein of unknown function DUF115
BSM4216_3301	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BSM4216_3312	COG0531	amino acid
BSM4216_3313	COG0531	amino acid
BSM4216_3314	COG2172	sigma factor antagonist activity
BSM4216_3315	COG1366	Belongs to the anti-sigma-factor antagonist family
BSM4216_3316	COG0531	amino acid
BSM4216_3317	COG0473	3-isopropylmalate dehydrogenase activity
BSM4216_3319	COG3180	Ammonia monooxygenase
BSM4216_3320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BSM4216_3321	COG1929	Belongs to the glycerate kinase type-1 family
BSM4216_3322	COG2610	gluconate transmembrane transporter activity
BSM4216_3325	COG2132	Multicopper oxidase
BSM4216_3328	COG2814	Major facilitator Superfamily
BSM4216_3342	COG3711	transcriptional antiterminator
BSM4216_3348	COG1346	cytolysis
BSM4216_3349	COG1380	Effector of murein hydrolase LrgA
BSM4216_3350	COG1846	Transcriptional regulator
BSM4216_3354	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSM4216_3356	COG0531	amino acid
BSM4216_3357	COG0655	NAD(P)H dehydrogenase (quinone) activity
BSM4216_3361	COG0667	Aldo Keto reductase
BSM4216_3364	COG1280	lysine exporter protein (LysE YggA)
BSM4216_3369	COG4372	Transposase
BSM4216_3390	COG1396	sequence-specific DNA binding
BSM4216_3392	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSM4216_3393	COG2132	Multicopper oxidase
BSM4216_3394	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BSM4216_3395	COG1597	lipid kinase activity
BSM4216_3398	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BSM4216_3399	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BSM4216_3400	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BSM4216_3401	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BSM4216_3403	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSM4216_3404	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BSM4216_3405	COG3344	reverse transcriptase
BSM4216_3407	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSM4216_3408	COG0154	amidase activity
BSM4216_3409	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BSM4216_3410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BSM4216_3411	COG2224	Isocitrate lyase
BSM4216_3412	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BSM4216_3413	COG4851	CamS sex pheromone cAM373 precursor
BSM4216_3414	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BSM4216_3415	COG0210	DNA helicase
BSM4216_3418	COG4496	protein, YerC YecD
BSM4216_3422	COG0151	Belongs to the GarS family
BSM4216_3424	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BSM4216_3425	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BSM4216_3426	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BSM4216_3428	COG0047	phosphoribosylformylglycinamidine synthase activity
BSM4216_3429	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BSM4216_3430	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BSM4216_3431	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BSM4216_3432	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BSM4216_3433	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BSM4216_3439	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_3439	COG1263	PTS System
BSM4216_3439	COG2190	(PTS) system
BSM4216_3440	COG3711	transcriptional antiterminator
BSM4216_3441	COG2252	PERMEase
BSM4216_3442	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BSM4216_3442	COG0519	Catalyzes the synthesis of GMP from XMP
BSM4216_3444	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BSM4216_3445	COG1335	isochorismatase
BSM4216_3451	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BSM4216_3452	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
BSM4216_3454	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BSM4216_3455	COG0436	Aminotransferase
BSM4216_3456	COG1850	ribulose-bisphosphate carboxylase activity
BSM4216_3457	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
BSM4216_3458	COG0235	Class ii aldolase
BSM4216_3459	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
BSM4216_3460	COG2201	protein-glutamate methylesterase activity
BSM4216_3462	COG1525	nuclease
BSM4216_3463	COG3328	transposase activity
BSM4216_3465	COG0459	protein refolding
BSM4216_3466	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BSM4216_3468	COG1266	CAAX protease self-immunity
BSM4216_3473	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSM4216_3476	COG0745	RESPONSE REGULATOR receiver
BSM4216_3477	COG0577	efflux transmembrane transporter activity
BSM4216_3477	COG1136	(ABC) transporter
BSM4216_3478	COG1136	(ABC) transporter
BSM4216_3480	COG0805	protein transport
BSM4216_3481	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BSM4216_3482	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BSM4216_3485	COG0488	(ABC) transporter
BSM4216_3487	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BSM4216_3488	COG0456	acetyltransferase
BSM4216_3489	COG1214	PFAM Peptidase M22, glycoprotease
BSM4216_3490	COG0802	atpase or kinase
BSM4216_3509	COG2183	response to ionizing radiation
BSM4216_3511	COG1191	sigma factor activity
BSM4216_3512	COG2172	sigma factor antagonist activity
BSM4216_3515	COG2337	Toxic component of a toxin-antitoxin (TA) module
BSM4216_3516	COG0864	Transcriptional regulator
BSM4216_3519	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BSM4216_3520	COG0736	holo-[acyl-carrier-protein] synthase activity
BSM4216_3521	COG0705	Rhomboid family
BSM4216_3523	COG0513	Belongs to the DEAD box helicase family
BSM4216_3526	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BSM4216_3527	COG1181	Belongs to the D-alanine--D-alanine ligase family
BSM4216_3528	COG2814	Major facilitator Superfamily
BSM4216_3530	COG2239	Acts as a magnesium transporter
BSM4216_3531	COG1253	flavin adenine dinucleotide binding
BSM4216_3532	COG1253	flavin adenine dinucleotide binding
BSM4216_3534	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSM4216_3538	COG1253	flavin adenine dinucleotide binding
BSM4216_3539	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BSM4216_3544	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BSM4216_3546	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BSM4216_3547	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BSM4216_3549	COG1966	Carbon starvation protein
BSM4216_3551	COG1164	Oligoendopeptidase f
BSM4216_3553	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BSM4216_3554	COG0791	NLP P60 protein
BSM4216_3555	COG0726	polysaccharide deacetylase
BSM4216_3557	COG0347	Belongs to the P(II) protein family
BSM4216_3558	COG0004	ammonium transporteR
BSM4216_3563	COG1472	Belongs to the glycosyl hydrolase 3 family
BSM4216_3566	COG0438	transferase activity, transferring glycosyl groups
BSM4216_3569	COG0297	glycogen (starch) synthase activity
BSM4216_3572	COG0728	peptidoglycan biosynthetic process
BSM4216_3576	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BSM4216_3576	COG1263	PTS System
BSM4216_3578	COG1486	melibiose metabolic process
BSM4216_3579	COG1737	Transcriptional regulator
BSM4216_3580	COG2190	(PTS) system
BSM4216_3582	COG2076	Multidrug Resistance protein
BSM4216_3584	COG0463	Glycosyl transferase, family 2
BSM4216_3587	COG0670	Belongs to the BI1 family
BSM4216_3594	COG4990	cell redox homeostasis
BSM4216_3595	COG0475	glutathione-regulated potassium exporter activity
BSM4216_3595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BSM4216_3598	COG0840	transmembrane signaling receptor activity
BSM4216_3609	COG5002	protein histidine kinase activity
BSM4216_3618	COG0728	peptidoglycan biosynthetic process
BSM4216_3624	COG5263	repeat protein
BSM4216_3624	COG4193	domain, Protein
BSM4216_3626	COG0791	NLP P60 protein
BSM4216_3627	COG1404	Belongs to the peptidase S8 family
BSM4216_3630	COG1785	Belongs to the alkaline phosphatase family
BSM4216_3631	COG4715	Zinc finger, swim domain protein
BSM4216_3632	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BSM4216_3635	COG0629	single-stranded DNA binding
BSM4216_3645	COG4786	Flagellar basal body rod
BSM4216_3646	COG4786	Flagellar basal body rod
BSM4216_3647	COG1077	Cell shape determining protein MreB Mrl
BSM4216_3648	COG1609	Transcriptional regulator
BSM4216_3649	COG0739	heme binding
BSM4216_3650	COG2385	sporulation resulting in formation of a cellular spore
BSM4216_3652	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSM4216_3654	COG4836	Membrane
BSM4216_3656	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BSM4216_3657	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BSM4216_3658	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BSM4216_3659	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BSM4216_3660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSM4216_3661	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BSM4216_3662	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BSM4216_3663	COG0356	it plays a direct role in the translocation of protons across the membrane
BSM4216_3665	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BSM4216_3666	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BSM4216_3669	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BSM4216_3672	COG0698	ribose 5-phosphate isomerase
BSM4216_3673	COG0840	transmembrane signaling receptor activity
BSM4216_3675	COG1971	Probably functions as a manganese efflux pump
BSM4216_3677	COG0009	L-threonylcarbamoyladenylate synthase
BSM4216_3678	COG1668	transmembrane transport
BSM4216_3679	COG4152	abc transporter atp-binding protein
BSM4216_3683	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BSM4216_3685	COG1435	thymidine kinase activity
BSM4216_3687	COG0254	rRNA binding
BSM4216_3688	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BSM4216_3689	COG1494	fructose-1,6-bisphosphatase
BSM4216_3690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BSM4216_3692	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BSM4216_3693	COG0191	fructose-bisphosphate aldolase activity
BSM4216_3694	COG2204	response regulator
BSM4216_3696	COG0504	CTP synthase activity
BSM4216_3697	COG3343	RNA polymerase activity
BSM4216_3703	COG1960	acyl-CoA dehydrogenase activity
BSM4216_3704	COG1960	acyl-CoA dehydrogenase activity
BSM4216_3705	COG1250	3-hydroxyacyl-CoA dehydrogenase
BSM4216_3706	COG0183	Belongs to the thiolase family
BSM4216_3707	COG0247	lactate metabolic process
BSM4216_3707	COG2181	nitrate reductase activity
BSM4216_3708	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BSM4216_3711	COG0018	arginyl-trna synthetase
BSM4216_3712	COG4506	Protein conserved in bacteria
BSM4216_3713	COG0010	Belongs to the arginase family
BSM4216_3714	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BSM4216_3715	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BSM4216_3718	COG1994	Peptidase M50
BSM4216_3721	COG3465	dGTPase activity
BSM4216_3722	COG1078	dGTPase activity
BSM4216_3725	COG4844	belongs to the
BSM4216_3727	COG1879	ABC-type sugar transport system periplasmic component
BSM4216_3728	COG1172	Belongs to the binding-protein-dependent transport system permease family
BSM4216_3729	COG1129	ABC transporter
BSM4216_3730	COG1869	D-ribose catabolic process
BSM4216_3731	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BSM4216_3732	COG1609	Transcriptional regulator
BSM4216_3738	COG2363	Small membrane protein
BSM4216_3740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BSM4216_3742	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BSM4216_3744	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BSM4216_3745	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BSM4216_3746	COG0314	molybdopterin synthase activity
BSM4216_3747	COG0746	molybdenum cofactor guanylyltransferase activity
BSM4216_3749	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BSM4216_3754	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BSM4216_3755	COG0561	phosphatase activity
BSM4216_3760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BSM4216_3761	COG3279	Response regulator of the LytR AlgR family
BSM4216_3763	COG0427	acetyl-CoA hydrolase
BSM4216_3766	COG3328	transposase activity
BSM4216_3767	COG1368	sulfuric ester hydrolase activity
BSM4216_3768	COG2226	methyltransferase
BSM4216_3772	COG1388	LysM domain
BSM4216_3772	COG3858	chitin binding
BSM4216_3777	COG2851	Citrate transporter
BSM4216_3778	COG1470	cell adhesion involved in biofilm formation
BSM4216_3780	COG5434	Belongs to the glycosyl hydrolase 28 family
BSM4216_3783	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSM4216_3784	COG1442	glycosyl transferase family 8
BSM4216_3791	COG2195	Cleaves the N-terminal amino acid of tripeptides
BSM4216_3792	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BSM4216_3793	COG0697	spore germination
BSM4216_3794	COG2140	Oxalate decarboxylase
BSM4216_3796	COG1309	transcriptional regulator
BSM4216_3797	COG1846	Transcriptional regulator
BSM4216_3798	COG0477	Major facilitator Superfamily
BSM4216_3813	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BSM4216_3818	COG1428	Deoxynucleoside kinase
BSM4216_3820	COG1620	l-lactate permease
BSM4216_3824	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BSM4216_3826	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BSM4216_3827	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BSM4216_3830	COG5002	protein histidine kinase activity
BSM4216_3831	COG0745	RESPONSE REGULATOR receiver
BSM4216_3838	COG0305	Participates in initiation and elongation during chromosome replication
BSM4216_3839	COG0359	binds to the 23S rRNA
BSM4216_3840	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
BSM4216_3841	COG4241	membrane
BSM4216_3842	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BSM4216_3843	COG0629	single-stranded DNA binding
BSM4216_3844	COG0360	Binds together with S18 to 16S ribosomal RNA
BSM4216_3846	COG0012	GTP binding
BSM4216_3849	COG4481	Protein conserved in bacteria
BSM4216_3850	COG0668	transmembrane transport
BSM4216_3853	COG1475	DNA binding
BSM4216_3854	COG1192	Involved in chromosome partitioning
BSM4216_3855	COG1475	DNA binding
BSM4216_3856	COG0357	Ribosomal RNA small subunit methyltransferase G
BSM4216_3857	COG0445	tRNA wobble uridine modification
BSM4216_3858	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BSM4216_3861	COG0594	ribonuclease P activity
BSM4216_3862	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BSM4216_3871	COG0582	viral genome integration into host DNA
BSM4216_3873	COG2336	PFAM SpoVT AbrB
BSM4216_3874	COG2337	Toxic component of a toxin-antitoxin (TA) module
BSM4216_3880	COG4372	Transposase