locus-tag class description S101395_00001 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) S101395_00002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) S101395_00003 ENOG410848D S4 domain protein YaaA S101395_00004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) S101395_00005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101395_00006 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101395_00013 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) S101395_00015 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) S101395_00016 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) S101395_00017 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) S101395_00018 ENOG4105BZW Glycerate kinase S101395_00019 ENOG4107QQ0 gntp family S101395_00020 ENOG4107VHA regulatoR S101395_00023 ENOG4105ZMH deoxynucleoside kinase S101395_00025 ENOG4105VRS hydrolase family 18 S101395_00026 ENOG4105GTG Isochorismatase S101395_00027 ENOG4108Z6B deaminase S101395_00028 ENOG4105C6E dna polymerase iii S101395_00029 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) S101395_00030 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) S101395_00032 ENOG41067KS pro-sigma K processing S101395_00040 ENOG4105CDW Resistance protein S101395_00041 ENOG4105CXN decarboxylase S101395_00042 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) S101395_00043 ENOG4105X0R protein from nitrogen regulatory protein P-II S101395_00044 ENOG4105XVJ Protein of unknown function (DUF327) S101395_00045 ENOG4105FA2 dna polymerase iii S101395_00046 ENOG4105MA4 psp1 domain protein S101395_00047 ENOG41063V3 Involved in initiation control of chromosome replication (By similarity) S101395_00048 ENOG41060K3 Methyltransferase S101395_00049 ENOG4105VC4 domain protein S101395_00050 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) S101395_00051 ENOG4105KRN Transcriptional regulator, abrb family S101395_00052 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) S101395_00053 ENOG4105F8V Hydrolase, tatD family S101395_00054 ENOG41069ER domain protein S101395_00056 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) S101395_00057 ENOG4105XFA sporulation peptidase YabG S101395_00058 ENOG4105W42 Veg protein S101395_00059 ENOG4105XEW small acid-soluble spore protein S101395_00060 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) S101395_00061 ENOG4105DFT pur operon repressor S101395_00062 ENOG4105KME endoribonuclease L-psp S101395_00063 ENOG4105K4W Could be involved in septation (By similarity) S101395_00064 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) S101395_00065 ENOG4105C5T Phosphoribosyl pyrophosphate synthase S101395_00066 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) S101395_00069 ENOG4108JA2 transcriptioN-repair coupling factor S101395_00070 ENOG4108M14 stage v sporulation protein t S101395_00072 ENOG4108IY2 MazG family S101395_00073 ENOG41082I2 s4 domain protein S101395_00074 ENOG4105VYY sporulation protein yabp S101395_00077 ENOG41060GV RNA binding s1 domain protein S101395_00083 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) S101395_00084 ENOG4108UGV hypoxanthine phosphoribosyltransferase S101395_00085 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) S101395_00086 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) S101395_00087 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) S101395_00088 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase S101395_00089 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase S101395_00090 ENOG4105C6T cysteine synthase S101395_00091 ENOG4105CRQ synthase (Component I) S101395_00092 ENOG4105DDQ anthranilate synthase S101395_00093 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 S101395_00094 ENOG4105EEI dihydropteroate synthase S101395_00095 ENOG4105KRF dihydroneopterin aldolase S101395_00096 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase S101395_00098 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) S101395_00099 ENOG4105CRK lysyL-tRNA synthetase S101395_00100 ENOG4105CRK lysyL-tRNA synthetase S101395_00117 ENOG4108Z0C Uvrb UvrC protein S101395_00118 ENOG41066A3 ATP guanido phosphotransferase S101395_00120 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) S101395_00121 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) S101395_00122 ENOG4105CTP PilT protein domain protein S101395_00123 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) S101395_00124 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) S101395_00125 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) S101395_00126 ENOG4105D7W serine acetyltransferase S101395_00127 ENOG4105C8N cysteinyl-tRNA synthetase S101395_00128 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) S101395_00129 ENOG4105C2N RNA methyltransferase TrmH family group 3 S101395_00130 ENOG4105M0M Tetracycline resistance protein S101395_00131 ENOG4105QIV RNA polymerase S101395_00132 ENOG410683Z Preprotein translocase SecE subunit S101395_00133 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) S101395_00134 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) S101395_00135 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) S101395_00136 ENOG4108VZM 50s ribosomal protein L10 S101395_00137 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) S101395_00138 ENOG4107Y49 methyltransferase S101395_00139 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101395_00140 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101395_00141 ENOG4105XPM ribosomal protein S101395_00142 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) S101395_00143 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) S101395_00144 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) S101395_00145 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) S101395_00146 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) S101395_00147 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) S101395_00148 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) S101395_00149 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity S101395_00150 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) S101395_00151 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) S101395_00152 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) S101395_00153 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) S101395_00154 ENOG41082SA 50s ribosomal protein l29 S101395_00155 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal S101395_00156 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) S101395_00157 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) S101395_00158 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits S101395_00159 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S101395_00160 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) S101395_00161 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) S101395_00162 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) S101395_00163 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) S101395_00164 ENOG4105VPB 50S ribosomal protein L30 S101395_00165 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) S101395_00166 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) S101395_00167 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) S101395_00168 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) S101395_00170 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) S101395_00172 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits S101395_00173 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) S101395_00174 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) S101395_00175 ENOG4108ZT0 50S ribosomal protein l17 S101395_00176 ENOG4108JJB ABC transporter S101395_00177 ENOG4108JJB ABC transporter S101395_00178 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) S101395_00179 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) S101395_00180 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) S101395_00181 ENOG4108UJD 30S ribosomal protein S9 S101395_00192 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism S101395_00198 ENOG4105D1F ATP-binding protein S101395_00201 ENOG4108NMV polysaccharide deacetylase S101395_00208 ENOG4105ETE Transcriptional regulator (LacI family S101395_00210 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component S101395_00211 ENOG4105DRS transport system, permease S101395_00213 ENOG4108HKT sucrose-6-phosphate hydrolase S101395_00214 ENOG4105D7K pfkb domain protein S101395_00215 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S101395_00217 ENOG4105JVQ RNA Polymerase S101395_00220 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101395_00224 ENOG4105CK1 PTS System S101395_00225 ENOG4105CS2 ec 3.2.1.21 S101395_00227 ENOG4105C5B carbamate kinase S101395_00229 ENOG4105DBV ornithine carbamoyltransferase S101395_00230 ENOG4105CEU Arginine dihydrolase S101395_00231 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) S101395_00232 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) S101395_00234 ENOG4105E0M Sulfatase S101395_00239 ENOG4105X3H Excalibur domain protein S101395_00240 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101395_00241 ENOG4105D2K citrate carrier protein S101395_00247 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101395_00248 ENOG4107BJW polysaccharide deacetylase S101395_00257 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) S101395_00258 ENOG4108IMY Transcriptional regulator S101395_00259 ENOG4105HDK L-asparaginase S101395_00260 ENOG4108IJ0 Aspartate ammonia-lyase S101395_00261 ENOG4105DFD Na H antiporter S101395_00264 ENOG4108QTI )-transporter S101395_00266 ENOG4105C4M (Ubiquinol oxidase) subunit I S101395_00267 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii S101395_00268 ENOG4108JJ9 ABC, transporter S101395_00269 ENOG4108JJ8 (ABC) transporter S101395_00271 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) S101395_00272 ENOG4108J20 pectate lyase S101395_00273 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S101395_00276 ENOG4105CH6 catalase S101395_00281 ENOG41069JR S101395_00282 ENOG4105DA5 (ABC) transporter S101395_00284 ENOG4105C2C drug resistance transporter, Bcr CflA S101395_00286 ENOG4107TDE lipolytic protein G-D-S-L family S101395_00287 ENOG4105BZ1 (ABC) transporter S101395_00290 ENOG4105CR4 methylisocitrate lyase S101395_00291 ENOG4105DXD 2-methylcitrate dehydratase S101395_00293 ENOG4108QBF Transcriptional regulator S101395_00295 ENOG4105C5E polysaccharide biosynthesis protein S101395_00296 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase S101395_00297 ENOG4108VX5 3-methyladenine DNA glycosylase S101395_00299 ENOG4105EMD TRANSCRIPTIONal S101395_00300 ENOG4105VZJ PTS System S101395_00301 ENOG4105CK1 PTS System S101395_00302 ENOG4105VCP PTS System S101395_00303 ENOG4105F8D glycoside hydrolase family 4 S101395_00305 ENOG4105CM2 brancheD-chain amino acid aminotransferase S101395_00306 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD S101395_00307 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) S101395_00308 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein S101395_00309 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) S101395_00313 ENOG4105D3W isochorismatase S101395_00314 ENOG41080V3 Major Facilitator superfamily S101395_00319 ENOG4105IIU Aminopeptidase S101395_00320 ENOG4105J4Q Transcriptional regulator S101395_00321 ENOG4105D7K pfkb domain protein S101395_00322 ENOG4108UHU Aldolase S101395_00323 ENOG4105CXK mandelate racemase muconate lactonizing S101395_00324 ENOG4105DJB Major Facilitator Superfamily S101395_00326 ENOG4105EYF MMPL domain protein S101395_00327 ENOG4108VB1 regulatoR S101395_00328 ENOG4105ENE Histidine kinase S101395_00331 ENOG4105X1N Glycosyl transferase family 8 S101395_00332 ENOG4105C5I Dehydrogenase S101395_00334 ENOG4105DR4 Methyltransferase S101395_00335 ENOG4105CK7 Sodium proline symporter S101395_00336 ENOG41067MG lrgb family S101395_00340 ENOG4105CMU LysR family (Transcriptional regulator S101395_00341 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase S101395_00342 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) S101395_00343 ENOG4105E2R ROK family S101395_00344 ENOG4105C93 Xylose Isomerase S101395_00345 ENOG4105CMG Carbohydrate kinase S101395_00348 ENOG4108WS4 fmn reductase S101395_00350 ENOG4105CMR udp-glucose 4-epimerase S101395_00351 ENOG4105E2S oxidase) subunit II S101395_00352 ENOG4105BZ9 Cytochrome C oxidase, subunit I S101395_00354 ENOG41060D1 Quinol oxidase S101395_00358 ENOG4105DWD nucleoside recognition domain protein S101395_00362 ENOG4108DBC nitroreductase S101395_00364 ENOG4105DEN Luciferase family S101395_00366 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin S101395_00369 ENOG4105C5Y PTS System S101395_00372 ENOG4105DWF phosphomethylpyrimidine kinase S101395_00373 ENOG4108RJ9 Glycosyl transferase, family 2 S101395_00374 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) S101395_00381 ENOG4105CJ1 ABC, transporter S101395_00385 ENOG4105CZN Potassium uptake protein S101395_00387 ENOG4107JTW chlorite dismutase S101395_00388 ENOG4108IJ2 phosphate acetyltransferase S101395_00390 ENOG4108FUF Transcriptional regulator, IclR family S101395_00395 ENOG4105D2S major facilitator superfamily S101395_00397 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) S101395_00399 ENOG4108VCI transcription factor, rsfa family S101395_00401 ENOG4105DCI Phosphohydrolase S101395_00404 ENOG41069HH 4-oxalocrotonate tautomerase S101395_00405 ENOG4108Z4T Peptidase M50 S101395_00406 ENOG4108XFG YwhD family S101395_00407 ENOG4105BZ4 penicillin-binding protein S101395_00410 ENOG4105CJ1 ABC, transporter S101395_00413 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) S101395_00414 ENOG4105CYW agmatinase S101395_00415 ENOG410684U Domain of unknown function (DUF1934) S101395_00416 ENOG4105C75 arginyL-tRNA synthetase S101395_00420 ENOG4105DF6 Fe-S oxidoreductase S101395_00422 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase S101395_00423 ENOG4105C1G acyl-Coa dehydrogenase S101395_00424 ENOG4105C1G acyl-Coa dehydrogenase S101395_00426 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) S101395_00428 ENOG410812K response regulator receiver protein S101395_00429 ENOG4105D2N Aldolase S101395_00430 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway S101395_00431 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S101395_00432 ENOG4105CBT Fructose-1,6-bisphosphatase S101395_00433 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) S101395_00434 ENOG41082DI 50s ribosomal protein l31 S101395_00435 ENOG4107104 thymidine kinase S101395_00436 ENOG4105C6K Malic enzyme S101395_00437 ENOG4107TT2 Auxin Efflux Carrier S101395_00439 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase S101395_00440 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) S101395_00441 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) S101395_00444 ENOG4105TRI Hydrolase S101395_00448 ENOG4108ZXQ stage ii sporulation protein r S101395_00450 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S101395_00451 ENOG410815N Probably functions as a manganese efflux pump (By similarity) S101395_00452 ENOG4107WAU Protein tyrosine phosphatase S101395_00453 ENOG4108YZG isomerase S101395_00454 ENOG4108UIC UPF0340 protein S101395_00455 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) S101395_00456 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) S101395_00458 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) S101395_00461 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) S101395_00462 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) S101395_00463 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) S101395_00464 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) S101395_00465 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) S101395_00466 ENOG4106778 Protein of unknown function (DUF1146) S101395_00468 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) S101395_00471 ENOG4108TF4 von Willebrand factor, type A S101395_00473 ENOG4105FCD Major Facilitator S101395_00474 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) S101395_00475 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) S101395_00479 ENOG4108Z40 Transcriptional regulator S101395_00480 ENOG4108RYK Nad-dependent epimerase dehydratase S101395_00481 ENOG4106BRK S101395_00482 ENOG410874W AraC family transcriptional regulator S101395_00486 ENOG4105NIV Esterase S101395_00487 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase S101395_00488 ENOG4105E4F Isochorismate synthase S101395_00489 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase S101395_00490 ENOG4105WQI isochorismatase S101395_00491 ENOG4105CEY Amp-dependent synthetase and ligase S101395_00492 ENOG4105WQT MbtH domain protein S101395_00493 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101395_00494 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) S101395_00496 ENOG4107TCE N-acetyltransferase S101395_00497 ENOG4105FRN stage II sporulation protein S101395_00501 ENOG4105BZU Histidine kinase S101395_00502 ENOG4105C37 (CBS) domain S101395_00504 ENOG41080XP Cbs domain S101395_00507 ENOG4108NA0 Uncharacterized conserved protein (COG2071) S101395_00509 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase S101395_00510 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase S101395_00511 ENOG4105CZM Major Facilitator S101395_00512 ENOG4107MII Sugar-specific transcriptional regulator TrmB S101395_00513 ENOG4105MT0 Sporulation transcriptional regulator spoiiid S101395_00514 ENOG4105DFF Rod shape-determining protein mreb S101395_00516 ENOG4105CGA flagellar basal-body rod protein FlgG S101395_00517 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) S101395_00520 ENOG4105Z8H single-stranded DNA-binding protein S101395_00521 ENOG4105DKT Transcriptional regulator S101395_00523 ENOG410787A Pts system, glucitol sorbitol-specific S101395_00524 ENOG4105DZY Pts system, glucitol sorbitol-specific S101395_00525 ENOG4105VI0 Pts system, glucitol sorbitol-specific S101395_00526 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase S101395_00527 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) S101395_00528 ENOG4105E98 transcriptional regulator DeoR family S101395_00529 ENOG4105E98 transcriptional regulator DeoR family S101395_00530 ENOG410667J hydrolase S101395_00531 ENOG4105CQM Urea amidohydrolase subunit alpha S101395_00532 ENOG4105KI2 Urea amidohydrolase subunit beta S101395_00533 ENOG4108YZ9 Urea amidohydrolase subunit gamma S101395_00534 ENOG4105C0D helicase S101395_00535 ENOG4105KBK Zinc finger, swim domain protein S101395_00537 ENOG4105HTX biosynthesis protein S101395_00538 ENOG4105HTX biosynthesis protein S101395_00539 ENOG4108RB3 Capsular polysaccharide biosynthesis protein S101395_00540 ENOG4105C6Y Udp-glucose 6-dehydrogenase S101395_00541 ENOG4105FGV Chromate S101395_00542 ENOG4105CAH Chromate S101395_00545 ENOG4107RSM transcriptional regulator S101395_00547 ENOG4107FQX Alpha-acetolactate decarboxylase S101395_00548 ENOG41089UC methyltransferase, type 11 S101395_00549 ENOG41089UC methyltransferase, type 11 S101395_00550 ENOG4105C5Q Transcriptional regulator S101395_00551 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator S101395_00552 ENOG4105CNN ABC, transporter S101395_00553 ENOG4105CNN ABC, transporter S101395_00554 ENOG4105C2J ABC transporter S101395_00555 ENOG4105C2J ABC transporter S101395_00556 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) S101395_00557 ENOG4108RVA ribokinase S101395_00558 ENOG4105ETE Transcriptional regulator (LacI family S101395_00559 ENOG4105N98 Capsule biosynthesis protein capB S101395_00561 ENOG4105PNM synthesis protein S101395_00563 ENOG4105K4H Nlp p60 protein S101395_00564 ENOG4105J7I hydrolase S101395_00565 ENOG4108KGH TRANSCRIPTIONal S101395_00566 ENOG4105C54 Major Facilitator superfamily S101395_00568 ENOG4105E2A Dehydrogenase S101395_00569 ENOG4105CHR reductase S101395_00571 ENOG4108M60 Transcriptional regulator S101395_00572 ENOG4105D7K pfkb domain protein S101395_00573 ENOG4108UHU Aldolase S101395_00574 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) S101395_00575 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase S101395_00576 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) S101395_00577 ENOG4105DG6 mannose-6-phosphate isomerase S101395_00580 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) S101395_00582 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase S101395_00587 ENOG4105EY8 ABC transporter S101395_00589 ENOG4107SJB teichoic acid biosynthesis S101395_00591 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase S101395_00593 ENOG4107RZX Teichoic acid biosynthesis protein S101395_00594 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S101395_00595 ENOG4108KGH TRANSCRIPTIONal S101395_00597 ENOG4105JFG SpoIID LytB domain protein S101395_00598 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101395_00599 ENOG4105D3Q Sugar transferase S101395_00600 ENOG4105PSV Polysaccharide Biosynthesis Protein S101395_00601 ENOG4107RA4 Glycosyl transferase (Group 1 S101395_00602 ENOG4105C6Y Udp-glucose 6-dehydrogenase S101395_00603 ENOG4105C1B dTDP-glucose 4-6-dehydratase S101395_00604 ENOG4105QZI O-Antigen Polymerase S101395_00607 ENOG4107EF8 Glycosyl transferase (Group 1 S101395_00608 ENOG4105ESV Glycosyl transferase, family 4 S101395_00609 ENOG4108KGH TRANSCRIPTIONal S101395_00610 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein S101395_00611 ENOG4105BZU Histidine kinase S101395_00612 ENOG4105WH1 Two component transcriptional regulator luxr family S101395_00616 ENOG41081UC Inherit from COG: Competence protein S101395_00617 ENOG4105RU3 S101395_00620 ENOG4105E1Q flagellar hook-associated protein S101395_00621 ENOG4105DTJ flagellar hook-associated protein S101395_00622 ENOG4105MKD S101395_00623 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) S101395_00624 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) S101395_00625 ENOG4105I03 Flagellin S101395_00626 ENOG4105I03 Flagellin S101395_00627 ENOG4105I03 Flagellin S101395_00628 ENOG41083S7 flagellar protein FlaG S101395_00629 ENOG4107RT6 flagellar hook-associated S101395_00630 ENOG4105MQ3 flagellar protein FliS S101395_00633 ENOG4105MS2 ribosomal subunit Interface protein S101395_00634 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving S101395_00635 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) S101395_00638 ENOG4105CAK Cell division ATP-binding protein ftsE S101395_00639 ENOG4105CRP Part of the ABC transporter FtsEX involved in S101395_00641 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S101395_00642 ENOG4105CN1 protease S101395_00647 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) S101395_00648 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) S101395_00651 ENOG4108PY7 S101395_00652 ENOG41067S9 phage shock protein C, PspC S101395_00653 ENOG41086DT Membrane protein of unknown function S101395_00654 ENOG41088CQ domain protein S101395_00655 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101395_00656 ENOG410834F Transcriptional regulator S101395_00657 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) S101395_00659 ENOG4105HKU nucleoside recognition domain-containing protein S101395_00660 ENOG4107XGZ Hydrolase S101395_00661 ENOG4108S4C acetyltransferase S101395_00662 ENOG4108E16 pectate lyase S101395_00663 ENOG4105VRS hydrolase family 18 S101395_00665 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) S101395_00666 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) S101395_00667 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) S101395_00668 ENOG4105ECC imidazole-glycerol-phosphate dehydratase S101395_00669 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) S101395_00670 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase S101395_00671 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) S101395_00672 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase S101395_00674 ENOG4105C3M thioredoxin reductase S101395_00675 ENOG4108Z4K mutator MutT protein S101395_00676 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) S101395_00677 ENOG4105CHW UPF0052 protein S101395_00678 ENOG4105CIE May be required for sporulation (By similarity) S101395_00679 ENOG4105KRI phosphocarrier protein (HPr S101395_00680 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase S101395_00682 ENOG4105EWM Histidine kinase S101395_00683 ENOG4105C19 ABC transporter S101395_00685 ENOG4108ZHR arsR family transcriptional regulator S101395_00686 ENOG4108SQ9 flavin reductase domain protein, FMN-binding S101395_00687 ENOG4105C5I Dehydrogenase S101395_00688 ENOG4108V2W Carbonate dehydratase S101395_00689 ENOG4105CHH sulfate transporter S101395_00690 ENOG4107TVP HD domain protein S101395_00691 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain S101395_00692 ENOG4108URH decarboxylase S101395_00694 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101395_00696 ENOG4106ANW SMI1_KNR4 S101395_00699 ENOG4108HKT sucrose-6-phosphate hydrolase S101395_00700 ENOG4105EDQ levansucrase EC 2.4.1.10 S101395_00701 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101395_00703 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S101395_00706 ENOG4105HTX biosynthesis protein S101395_00707 ENOG4108QV3 biosynthesis protein S101395_00709 ENOG4108PQP glycosyl transferase group 1 S101395_00710 ENOG4105K64 Glycosyl transferase, family 2 S101395_00711 ENOG4108KMV Glycosyl transferase (Group 1 S101395_00712 ENOG41068W6 Capsular polysaccharide biosynthesis protein S101395_00713 ENOG4107QRS glycosyltransferase group 2 family protein S101395_00715 ENOG4105K64 Glycosyl transferase, family 2 S101395_00717 ENOG4105D3Q Sugar transferase S101395_00718 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family S101395_00719 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase S101395_00720 ENOG4108ZPC Polysaccharide pyruvyl transferase S101395_00722 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101395_00723 ENOG4105DAA L-lactate S101395_00724 ENOG4105JXH GntR family transcriptional regulator S101395_00725 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S101395_00732 ENOG4105CIG ABC transporter S101395_00735 ENOG4105DEN Luciferase family S101395_00738 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S101395_00739 ENOG4105BZA Phosphoglycerate kinase S101395_00740 ENOG4105CP7 Triose-phosphate isomerase S101395_00741 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) S101395_00742 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) S101395_00744 ENOG4108MES Periplasmic binding protein S101395_00745 ENOG4105T65 Membrane-associated protein S101395_00747 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein S101395_00748 ENOG4107HG4 Transcriptional regulator S101395_00749 ENOG4108IJ8 ABC transporter S101395_00750 ENOG4105E90 ABC transporter S101395_00751 ENOG4108HQR Glycine betaine S101395_00752 ENOG4105R40 Glycine betaine carnitine choline S101395_00757 ENOG4105XZU Preprotein translocase, subunit SecG S101395_00759 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) S101395_00760 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) S101395_00795 ENOG4105CAR Terminase, large subunit S101395_00798 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101395_00808 ENOG4108FKH Transglycosylase SLT domain S101395_00810 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101395_00812 ENOG41068G1 S101395_00828 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) S101395_00833 ENOG4108X07 Tetr family transcriptional regulator S101395_00834 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S101395_00837 ENOG4105K78 MarR family Transcriptional regulator S101395_00838 ENOG4108VHC Short-chain dehydrogenase reductase Sdr S101395_00839 ENOG4105EBR Carboxylesterase S101395_00842 ENOG41082BM Transcriptional regulator, arsr family S101395_00844 ENOG4108NGU Transcriptional regulator S101395_00845 ENOG4105N14 lysine exporter protein LysE YggA S101395_00846 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S101395_00852 ENOG4108ZJ4 polysaccharide deacetylase S101395_00854 ENOG4105FKQ transcriptional regulator S101395_00855 ENOG4108IUK alpha amylase, catalytic S101395_00856 ENOG4107FKK extracellular solute-binding protein family 1 S101395_00857 ENOG4105D56 permease protein S101395_00858 ENOG4105EG2 ABC transporter, permease S101395_00861 ENOG4105CG3 alpha amylase, catalytic region S101395_00862 ENOG4107URF beta-phospho-glucomutase S101395_00867 ENOG4105VMP Transcriptional regulator S101395_00868 ENOG4105NX3 Membrane S101395_00876 ENOG4107STQ Multicopper oxidase S101395_00879 ENOG4105C7R Atpase associated with various cellular activities aaa_3 S101395_00882 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) S101395_00883 ENOG4105C7N Xanthine uracil vitamin C permease S101395_00886 ENOG4108U5N UPF0316 protein S101395_00888 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) S101395_00889 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit S101395_00890 ENOG4105C83 adenylosuccinate lyase S101395_00891 ENOG4105C8V SAICAR synthetase S101395_00892 ENOG4105VR9 phosphoribosylformylglycinamidine synthase S101395_00894 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii S101395_00896 ENOG4105CXB phosphoribosylaminoimidazole synthetase S101395_00897 ENOG4108V3E phosphoribosylglycinamide formyltransferase S101395_00898 ENOG4105DC1 bifunctional purine biosynthesis protein purh S101395_00899 ENOG4105C12 Phosphoribosylglycinamide synthetase S101395_00901 ENOG4106A3M Cytochrome p-450 S101395_00904 ENOG4108R5T secreted protein S101395_00905 ENOG4105KGF protein, YerC YecD S101395_00907 ENOG4105C4R Atp-dependent dna helicase S101395_00908 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) S101395_00911 ENOG4108M21 S101395_00913 ENOG4105MUZ Protein of unknown function DUF2620 S101395_00914 ENOG4106M0N transport system permease protein S101395_00915 ENOG41080QX K07048 phosphotriesterase-related protein S101395_00916 ENOG4106PKC pyridoxal phosphate binding S101395_00917 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S101395_00918 ENOG4108626 Racemase S101395_00920 ENOG4105KT7 mgtC SapB transporter S101395_00922 ENOG4105CK7 Sodium proline symporter S101395_00923 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S101395_00924 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) S101395_00925 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) S101395_00926 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S101395_00928 ENOG4108IG5 Transcriptional regulator S101395_00930 ENOG4105D9U N-acetyltransferase S101395_00931 ENOG4105DU0 nucleoside hydrolase S101395_00932 ENOG4105CBD Diacylglycerol kinase S101395_00933 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S101395_00936 ENOG4105C5Y PTS System S101395_00937 ENOG4105CS2 ec 3.2.1.21 S101395_00938 ENOG4105CID antiterminator S101395_00940 ENOG4108HFV S101395_00941 ENOG4107Y9U Membrane S101395_00943 ENOG4105CDY transcriptional regulatory protein S101395_00947 ENOG4107QPK )-transporter S101395_00948 ENOG4105C6K Malic enzyme S101395_00949 ENOG4107ZGM malolactic fermentation system S101395_00950 ENOG4105C26 Dehydrogenase S101395_00951 ENOG4105FKZ Methyl-accepting chemotaxis S101395_00952 ENOG4106BHF S101395_00953 ENOG4105C8P )-transporter S101395_00954 ENOG4105C5H ABC transporter S101395_00955 ENOG4105YVS arsR family transcriptional regulator S101395_00956 ENOG4107XZQ multidrug resistance protein S101395_00957 ENOG4105DZA Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity) S101395_00958 ENOG4107T5J pyridine nucleotide-disulfide oxidoreductase S101395_00960 ENOG4105CKI cobalamin synthesis protein S101395_00961 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) S101395_00962 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101395_00963 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S101395_00964 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) S101395_00965 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) S101395_00966 ENOG4106A3M Cytochrome p-450 S101395_00967 ENOG4107SWG transcriptional regulator MERR family S101395_00968 ENOG4105DXB Major Facilitator superfamily S101395_00969 ENOG4105C5H ABC transporter S101395_00970 ENOG4105FDU atp-dependent rna helicase S101395_00971 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S101395_00972 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S101395_00973 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein S101395_00976 ENOG4107QPK )-transporter S101395_00982 ENOG4105VRS hydrolase family 18 S101395_00985 ENOG41082BM Transcriptional regulator, arsr family S101395_00986 ENOG410855V Acylphosphatase S101395_00987 ENOG4108RPX mosc domain containing protein S101395_00990 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) S101395_00995 ENOG4105C5Y PTS System S101395_00996 ENOG4105CG3 alpha amylase, catalytic region S101395_00997 ENOG4107414 GntR family transcriptional regulator S101395_01001 ENOG4105K64 Glycosyl transferase, family 2 S101395_01002 ENOG4107TVC Glycosyl transferase, family 2 S101395_01006 ENOG4107QQG Dehydrogenase S101395_01008 ENOG4105KVH Transcriptional regulator S101395_01009 ENOG4108RCM Nitroreductase S101395_01010 ENOG4105CGH 5'-nucleotidase S101395_01011 ENOG4107RKG DJ-1/PfpI family S101395_01013 ENOG4105BZG amino acid carrier protein S101395_01014 ENOG4105KJF protein tyrosine phosphatase S101395_01016 ENOG4107U9T Pfam:Ribonuclease_BN S101395_01018 ENOG4108ISG Major Facilitator S101395_01020 ENOG4105UPD Calcium Proton S101395_01025 ENOG4105DCT glycerol dehydrogenase S101395_01026 ENOG41068VA S101395_01028 ENOG4105D7N magnesium and cobalt transport protein CorA S101395_01030 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) S101395_01034 ENOG41079KZ Major Facilitator Superfamily S101395_01039 ENOG4107RUY (E1 component), alpha subunit S101395_01041 ENOG4107QKR Dehydrogenase S101395_01043 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family S101395_01044 ENOG4105KK4 UPF0060 membrane protein S101395_01045 ENOG4105F8D glycoside hydrolase family 4 S101395_01046 ENOG4108Q3X Transcriptional regulator S101395_01047 ENOG4105CI1 PTS System S101395_01048 ENOG4105CI1 PTS System S101395_01049 ENOG4105CI1 PTS System S101395_01051 ENOG4105KVH Transcriptional regulator S101395_01053 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase S101395_01054 ENOG4105E4I Glycoside hydrolase family 28 S101395_01056 ENOG4105DSG hydrolase family 43 S101395_01057 ENOG4106HBX Transcriptional Regulator AraC Family S101395_01059 ENOG4105YA8 Transcriptional regulator S101395_01060 ENOG4107Y80 Major Facilitator superfamily S101395_01061 ENOG4105DYS nad(p)h dehydrogenase (quinone) S101395_01065 ENOG4105JAB phenazine biosynthesis protein, phzf family S101395_01066 ENOG4107Y03 Nitroreductase S101395_01070 ENOG4105ECP epimerase S101395_01071 ENOG410691R Modulates RecA activity (By similarity) S101395_01076 ENOG4107VFR oxidoreductase S101395_01077 ENOG4105CKK Glycosyl transferase, family 2 S101395_01079 ENOG4105EJV Membrane S101395_01080 ENOG4105EJV Membrane S101395_01081 ENOG41067AE Membrane-bound metal-dependent hydrolase S101395_01082 ENOG4105CEN a g-specific adenine glycosylase S101395_01083 ENOG4106BXE S101395_01084 ENOG4105CAN Short-chain dehydrogenase reductase Sdr S101395_01088 ENOG4105BZ1 (ABC) transporter S101395_01089 ENOG4105C3U ABC transporter S101395_01090 ENOG4108JQ7 (ABC) transporter S101395_01091 ENOG4105DEF Extracellular solute-binding protein, family 5 S101395_01092 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101395_01093 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101395_01094 ENOG4107NBY Membrane S101395_01095 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S101395_01096 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101395_01097 ENOG4105G5W regulator Fur family S101395_01098 ENOG4105TUA UPF0295 protein S101395_01118 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101395_01140 ENOG4108IMY Transcriptional regulator S101395_01158 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S101395_01159 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_01160 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_01213 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101395_01221 ENOG4105TRT Transcriptional regulator S101395_01222 ENOG4105C26 Dehydrogenase S101395_01223 ENOG4108JB8 alcohol dehydrogenase S101395_01224 ENOG4108VNY MOSC domain protein S101395_01225 ENOG4106DF1 S101395_01226 ENOG4106DF1 S101395_01227 ENOG4105CZN Potassium uptake protein S101395_01228 ENOG4107ZYR domain protein S101395_01229 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) S101395_01235 ENOG4105N67 Proton-coupled thiamine transporter YuaJ S101395_01236 ENOG4105CMD Transcriptional regulator, GntR family S101395_01267 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase S101395_01268 ENOG4105E4F Isochorismate synthase S101395_01269 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) S101395_01270 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) S101395_01271 ENOG4108IPT Naphthoate synthase S101395_01272 ENOG4105CEY Amp-dependent synthetase and ligase S101395_01273 ENOG4105DTQ mandelate racemase muconate lactonizing S101395_01274 ENOG4105CPU Monooxygenase S101395_01275 ENOG4108XSB acetyltransferase, (GNAT) family S101395_01276 ENOG4105EAB amino acid AbC transporter S101395_01277 ENOG4108HW4 amino acid AbC transporter S101395_01279 ENOG4105CH2 amidohydrolase S101395_01280 ENOG4108PGP mmge prpd family protein S101395_01286 ENOG4105DSE periplasmic solute binding protein S101395_01287 ENOG4108V2W Carbonate dehydratase S101395_01288 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) S101395_01289 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) S101395_01292 ENOG4108RMU ferritin dps family protein S101395_01297 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component S101395_01299 ENOG4105D2X ABC transporter substrate-binding protein S101395_01304 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP S101395_01305 ENOG4105CAQ asparagine synthetase S101395_01307 ENOG4105BZF Glycosyl transferase (Group 1 S101395_01308 ENOG4105YVM Phosphoesterase, PA-phosphatase related S101395_01309 ENOG4108Z0R Transferase S101395_01310 ENOG4105E8V Alpha Beta Hydrolase Fold protein S101395_01314 ENOG4105N5T Radical SAM Protein S101395_01317 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S101395_01318 ENOG4105DVE abc transporter atp-binding protein S101395_01320 ENOG4105C19 ABC transporter S101395_01321 ENOG4107R34 abc transporter permease protein S101395_01324 ENOG4105D01 (LipO)protein S101395_01325 ENOG410605W Major Facilitator S101395_01327 ENOG4105C8T Leucyl-tRNA synthetase S101395_01328 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase S101395_01329 ENOG4107V2S Transcriptional regulator S101395_01331 ENOG4105NTD Inherit from COG: Hydrolase S101395_01333 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S101395_01335 ENOG41075H3 AraC family transcriptional regulator S101395_01337 ENOG4105F5H Glycosyl Hydrolase Family 88 S101395_01339 ENOG4105DDC Oxidoreductase domain protein S101395_01340 ENOG4105DDC Oxidoreductase domain protein S101395_01341 ENOG4105MU9 integral membrane protein S101395_01345 ENOG41085GJ domain protein S101395_01346 ENOG4107QPK )-transporter S101395_01347 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) S101395_01348 ENOG4105E33 succinate dehydrogenase S101395_01349 ENOG41086B8 CoB-CoM heterodisulfide reductase S101395_01353 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) S101395_01354 ENOG4105G63 Type III effector Hrp-dependent S101395_01355 ENOG4105E98 transcriptional regulator DeoR family S101395_01356 ENOG4105C94 Transporter S101395_01357 ENOG4105CBX hi0933 family S101395_01360 ENOG4105YW5 deoR family transcriptional regulator S101395_01361 ENOG4105C7N Xanthine uracil vitamin C permease S101395_01362 ENOG4107QSE Dipeptidase S101395_01363 ENOG4105C6T cysteine synthase S101395_01364 ENOG4107F58 2'-5' rna ligase S101395_01367 ENOG4108V15 phosphotransferase enzyme family S101395_01369 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) S101395_01370 ENOG4105C8F Beta-lactamase domain protein S101395_01371 ENOG4105C6K Malic enzyme S101395_01374 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ S101395_01377 ENOG4108VDD TRNA binding domain protein S101395_01379 ENOG4105DFU Cell wall formation (By similarity) S101395_01384 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase S101395_01385 ENOG4105ETE Transcriptional regulator (LacI family S101395_01386 ENOG4107R0U MotA TolQ exbB proton channel S101395_01387 ENOG4105ER2 Ompa motb domain protein S101395_01388 ENOG4105DGU Histone deacetylase S101395_01389 ENOG4105W87 Cbs domain S101395_01390 ENOG4105F1V Acetoin utilization protein S101395_01392 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S101395_01394 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) S101395_01395 ENOG4105BZU Histidine kinase S101395_01397 ENOG4105U5Y Transcriptional regulator S101395_01402 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) S101395_01404 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S101395_01407 ENOG4105D07 Signal peptide peptidase, SppA S101395_01408 ENOG4105VK3 rdd domain containing protein S101395_01410 ENOG4105KBJ sporulation protein ytfj S101395_01411 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) S101395_01413 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) S101395_01414 ENOG4105EPU Molybdenum cofactor synthesis domain protein S101395_01415 ENOG4105CDH Citrulline--aspartate ligase S101395_01416 ENOG4105CH7 arginosuccinase S101395_01419 ENOG4105E8R UPF0173 metal-dependent hydrolase S101395_01420 ENOG4105U3E Transcriptional regulator S101395_01423 ENOG4105SFS phosphoesterase RecJ domain protein S101395_01424 ENOG4106EVM S101395_01426 ENOG4105VV2 S101395_01427 ENOG4105C0B DNA polymerase III (alpha subunit) S101395_01428 ENOG4105C6K Malic enzyme S101395_01430 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) S101395_01431 ENOG4105CTQ phosphohexokinase S101395_01432 ENOG4105CA9 Pyruvate kinase S101395_01433 ENOG4105FS0 cytoplasmic membrane protein S101395_01434 ENOG4108REF Sporulation integral membrane protein ytvi S101395_01435 ENOG4108VMM UPF0756 membrane protein S101395_01436 ENOG4105BZN citrate synthase S101395_01437 ENOG4108HMX isocitrate dehydrogenase (NADP) S101395_01438 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) S101395_01439 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101395_01440 ENOG4105BZU Histidine kinase S101395_01441 ENOG4105C2M dna polymerase I S101395_01442 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) S101395_01444 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) S101395_01445 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase S101395_01446 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) S101395_01448 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) S101395_01453 ENOG4108TDW sporulation protein YtxC S101395_01454 ENOG4105C22 threonyL-tRNA synthetase S101395_01455 ENOG4105U0R haloacid dehalogenase-like hydrolase S101395_01457 ENOG4108HRK Histidine kinase S101395_01458 ENOG4105DY9 regulatoR S101395_01459 ENOG4105DGI Alkaline phosphatase S101395_01460 ENOG41083D3 Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like protein CidA. The LrgAB and CidA proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses (By similarity) S101395_01461 ENOG41067MG lrgb family S101395_01462 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) S101395_01463 ENOG4105VJV 50s ribosomal protein L35 S101395_01464 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) S101395_01465 ENOG410696E Membrane S101395_01467 ENOG4105CN9 Peptidase m42 family protein S101395_01468 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase S101395_01469 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) S101395_01470 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) S101395_01471 ENOG4105EF1 ribulokinase S101395_01472 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase S101395_01473 ENOG4108MDK Dehydrogenase S101395_01476 ENOG4105DRS transport system, permease S101395_01480 ENOG410905X membrane-flanked domain protein S101395_01481 ENOG4107Z3H Transcriptional regulator, TetR family S101395_01483 ENOG41067MF small acid-soluble spore protein S101395_01484 ENOG4108RWN rrna methyltransferase S101395_01485 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) S101395_01486 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) S101395_01490 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S101395_01491 ENOG410687F Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) S101395_01493 ENOG4105DCG PHP domain protein S101395_01494 ENOG4105C98 muts2 protein S101395_01496 ENOG4105CEY Amp-dependent synthetase and ligase S101395_01497 ENOG4107Z3H Transcriptional regulator, TetR family S101395_01498 ENOG41060WC Enoyl-CoA hydratase S101395_01499 ENOG4105BZJ Electron transfer flavoprotein S101395_01500 ENOG4105C10 Electron transfer flavoprotein S101395_01501 ENOG4105K63 Thioredoxin S101395_01502 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) S101395_01503 ENOG4105CFH Aspartokinase S101395_01505 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit S101395_01507 ENOG4105E33 succinate dehydrogenase S101395_01509 ENOG4107JEE Short-chain dehydrogenase reductase Sdr S101395_01510 ENOG4105PFC Transcriptional regulator S101395_01511 ENOG41067TZ transcriptional regulator, MarR family S101395_01512 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) S101395_01513 ENOG4108M26 parallel beta-helix repeat protein S101395_01514 ENOG4108XJQ germination protein S101395_01515 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) S101395_01516 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) S101395_01517 ENOG4105M59 Phosphodiesterase, mj0936 family S101395_01525 ENOG4107R37 Glutamate dehydrogenase S101395_01527 ENOG4105CM2 brancheD-chain amino acid aminotransferase S101395_01528 ENOG4105C7K acetolactate synthase S101395_01529 ENOG4108ZP8 Acetolactate synthase small subunit S101395_01530 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase S101395_01531 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) S101395_01532 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) S101395_01533 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S101395_01534 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) S101395_01536 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation S101395_01537 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) S101395_01538 ENOG4108IUQ atp-dependent protease S101395_01539 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) S101395_01540 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) S101395_01542 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) S101395_01544 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) S101395_01546 ENOG4105D52 delta-aminolevulinic acid dehydratase S101395_01547 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase S101395_01548 ENOG41068KH stage VI sporulation protein D S101395_01549 ENOG4106AR7 Spore coat protein S101395_01551 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) S101395_01552 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase S101395_01553 ENOG4106A3R peptidase S101395_01555 ENOG4108Z03 MAF-like protein S101395_01556 ENOG4105W5Q DNA repair protein (RadC S101395_01557 ENOG4105DFF Rod shape-determining protein mreb S101395_01558 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) S101395_01559 ENOG4105YHC Rod shape-determining protein MreD S101395_01560 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) S101395_01561 ENOG4107QMS site-determining protein S101395_01562 ENOG41082BM Transcriptional regulator, arsr family S101395_01566 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) S101395_01567 ENOG4105X36 (ribosomal) protein S101395_01568 ENOG4105K46 50S ribosomal protein l27 S101395_01570 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control S101395_01571 ENOG41090I5 UPF0735 ACT domain-containing protein S101395_01572 ENOG4105CQC Prephenate dehydratase S101395_01575 ENOG4108IYU L-aspartate oxidase S101395_01576 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase S101395_01577 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) S101395_01578 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) S101395_01579 ENOG4106678 morphogenetic protein associated with SpoVID S101395_01581 ENOG4105CDY transcriptional regulatory protein S101395_01584 ENOG4105K7W phage-related replication protein S101395_01586 ENOG41069DP small acid-soluble spore protein S101395_01590 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) S101395_01591 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) S101395_01592 ENOG41061AI Protein of unknown function (DUF2905) S101395_01593 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) S101395_01594 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) S101395_01595 ENOG4105VIE preprotein translocase, subunit YajC S101395_01596 ENOG4105NAP S101395_01597 ENOG4108QG2 Membrane S101395_01598 ENOG4105CKP Polysaccharide Biosynthesis Protein S101395_01600 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) S101395_01601 ENOG4105NCW Trka-c domain protein S101395_01602 ENOG41067VP Protein of unknown function (DUF1049) S101395_01603 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) S101395_01604 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) S101395_01605 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) S101395_01606 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) S101395_01607 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101395_01609 ENOG4105CUT histidyl-tRNA synthetase S101395_01610 ENOG4105C9M aspartyl-trna synthetase S101395_01611 ENOG4105CUZ uba thif-type nad fad binding protein S101395_01614 ENOG4105D1H recombination factor protein RarA S101395_01616 ENOG4105C3J Cysteine desulfurase S101395_01617 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) S101395_01619 ENOG4105C7H Helicase, RecD TraA family S101395_01621 ENOG41060CR S101395_01622 ENOG4105C02 permease S101395_01623 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) S101395_01624 ENOG4105VBH UPF0297 protein S101395_01625 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) S101395_01626 ENOG4105HHA aminodeoxychorismate lyase S101395_01627 ENOG4108VQJ O-methyltransferase S101395_01628 ENOG4105XYU peptidase (U32 family) S101395_01629 ENOG4105CFP Peptidase U32 S101395_01631 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) S101395_01632 ENOG4107XRG penicillin-binding protein S101395_01635 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) S101395_01636 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) S101395_01638 ENOG4105C28 cystathionine S101395_01644 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101395_01645 ENOG41082JN Transcriptional regulator S101395_01646 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101395_01648 ENOG4105D94 Major Facilitator Superfamily S101395_01649 ENOG4107RSM transcriptional regulator S101395_01651 ENOG4105EXQ uroporphyrinogen iii synthase hem4 S101395_01652 ENOG4105KVH Transcriptional regulator S101395_01653 ENOG4105F27 Major Facilitator S101395_01654 ENOG4105CV8 reductase S101395_01659 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S101395_01664 ENOG41068K0 YCII-related domain S101395_01667 ENOG4107Y9E nuclease S101395_01669 ENOG4105G7B Protein of unknown function (DUF2992) S101395_01670 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family S101395_01671 ENOG4105YHU PTS system S101395_01672 ENOG4108IQ3 PTS system S101395_01673 ENOG4105ETZ PTS System S101395_01674 ENOG4105F3R pts system mannose fructose sorbose family iid S101395_01675 ENOG4108HKT sucrose-6-phosphate hydrolase S101395_01676 ENOG4105CIB oxidoreductase Domain protein S101395_01677 ENOG4107QP6 Xylose isomerase domain protein TIM barrel S101395_01678 ENOG4105ID8 Transcriptional regulator, ARAC family S101395_01679 ENOG4105CT4 transporter S101395_01680 ENOG4105DSG hydrolase family 43 S101395_01682 ENOG4105D82 Glutamate dehydrogenase S101395_01689 ENOG4105C5X domain protein S101395_01692 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) S101395_01693 ENOG4105GVJ transcriptional regulator S101395_01694 ENOG4108V4B ThiJ pfpI S101395_01697 ENOG4105CI1 PTS System S101395_01701 ENOG4105C6Z Gluconate S101395_01702 ENOG41090U3 tautomerase S101395_01704 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101395_01706 ENOG4105DET Rhamnulokinase S101395_01707 ENOG4105DKG l-rhamnose isomerase S101395_01708 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) S101395_01709 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) S101395_01712 ENOG4105CAY ferredoxin--nadp reductase S101395_01714 ENOG41083Q9 chitosanase S101395_01718 ENOG4108S01 response regulator S101395_01719 ENOG4108ZGX Histidine kinase S101395_01720 ENOG4105ECK Fatty Acid Desaturase S101395_01721 ENOG4105KVH Transcriptional regulator S101395_01722 ENOG4108VA3 3-hexulose-6-phosphate synthase S101395_01723 ENOG41080HJ 6-phospho 3-hexuloisomerase S101395_01730 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) S101395_01731 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) S101395_01732 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) S101395_01736 ENOG4105KFN sortase, SrtB family S101395_01737 ENOG4105J76 Periplasmic binding protein S101395_01738 ENOG4105DQ5 transport system permease protein S101395_01739 ENOG4105E0A ABC, transporter S101395_01740 ENOG4105P9G heme-degrading monooxygenase IsdG S101395_01744 ENOG4107RHR regulatoR S101395_01746 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) S101395_01753 ENOG4105EA8 2-Nitropropane dioxygenase S101395_01756 ENOG4105DJ2 Major Facilitator Superfamily S101395_01758 ENOG4105KBH arsR family transcriptional regulator S101395_01759 ENOG4105C7F AcnD-accessory protein PrpF S101395_01760 ENOG4105JSC dimethylmenaquinone methyltransferase S101395_01761 ENOG4108KAM Transcriptional regulator S101395_01763 ENOG41068WN S101395_01764 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101395_01766 ENOG4108JB9 formate dehydrogenase S101395_01767 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) S101395_01771 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase S101395_01772 ENOG4105CQW ribosome biogenesis GTPase YqeH S101395_01773 ENOG4105CQW ribosome biogenesis GTPase YqeH S101395_01774 ENOG4105E2X shikimate dehydrogenase S101395_01775 ENOG410812S Rna-binding protein S101395_01776 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) S101395_01777 ENOG4108WF2 Metal Dependent Phosphohydrolase S101395_01779 ENOG4108D32 Methyltransferase S101395_01781 ENOG4105KQC Competence protein S101395_01782 ENOG4108UK2 deaminase S101395_01783 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 S101395_01785 ENOG4105TQK DNA polymerase iii, delta' subunit S101395_01788 ENOG4108ZRV stage ii sporulation protein p S101395_01790 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) S101395_01791 ENOG4105CSA Coproporphyrinogen iii oxidase S101395_01792 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) S101395_01793 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ S101395_01794 ENOG4105CFG Acts as a chaperone (By similarity) S101395_01795 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) S101395_01796 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) S101395_01797 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) S101395_01798 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S101395_01799 ENOG4105VRR gCN5-related N-acetyltransferase S101395_01801 ENOG4105VCC 30S ribosomal protein S21 S101395_01802 ENOG4105KTH gatB Yqey S101395_01803 ENOG4105F7J membrane-bound serine protease S101395_01804 ENOG4105DI5 UPF0365 protein S101395_01806 ENOG41068P3 sporulation protein YqfC S101395_01807 ENOG4105EI1 sporulation protein yqfd S101395_01808 ENOG4105C9A Phoh family S101395_01809 ENOG4105CTJ Metal Dependent Phosphohydrolase S101395_01810 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) S101395_01811 ENOG4107YR5 Diacylglycerol kinase S101395_01812 ENOG4105KG3 cytidine deaminase S101395_01813 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) S101395_01815 ENOG4108SAY Involved in DNA repair and RecF pathway recombination (By similarity) S101395_01816 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit S101395_01817 ENOG4105C38 Glycyl-tRNA synthetase beta subunit S101395_01819 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) S101395_01821 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) S101395_01822 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101395_01827 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) S101395_01829 ENOG4105EGD dinuclear metal center protein, YbgI family S101395_01830 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) S101395_01833 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) S101395_01834 ENOG41069ZM Protein of unknown function (DUF2624) S101395_01835 ENOG4108JYZ YitT family S101395_01836 ENOG4105FDK ABC transporter S101395_01837 ENOG4105FAV ABC, transporter S101395_01838 ENOG4105N80 Ferric uptake regulator, Fur family S101395_01839 ENOG4108U5J '-nucleotidase S101395_01840 ENOG41063Y9 S101395_01841 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) S101395_01844 ENOG4105SXS Protein of unknown function (DUF456) S101395_01845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S101395_01847 ENOG4107RF6 penicillin-binding protein S101395_01848 ENOG4105CVA phosphate S101395_01849 ENOG4105C8U phosphate abc transporter S101395_01850 ENOG4105E2Z phosphate ABC transporter (Permease S101395_01851 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S101395_01852 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) S101395_01853 ENOG41068DG YceG-like family S101395_01855 ENOG4105WDJ 50S ribosomal protein L33 S101395_01856 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase S101395_01858 ENOG4107ZXI Rhomboid family S101395_01862 ENOG4105E0M Sulfatase S101395_01869 ENOG4105C5X domain protein S101395_01879 ENOG410635T phage-like element pbsx protein S101395_01889 ENOG4108NF7 phage-type endonuclease S101395_01890 ENOG4108PNI recT protein S101395_01893 ENOG4105CDU Replicative dna helicase S101395_01897 ENOG4105QBX endodeoxyribonuclease RusA S101395_01916 ENOG4105IG6 Phage terminase, large subunit S101395_01917 ENOG4108MDF Phage Portal Protein S101395_01918 ENOG4106CGH Phage Mu protein F like protein S101395_01925 ENOG41060SN S101395_01927 ENOG4105PQS phage protein S101395_01928 ENOG4105FR7 XkdM protein, phage-like element PBSX S101395_01930 ENOG4105MTC XkdN-like protein S101395_01932 ENOG4108FKH Transglycosylase SLT domain S101395_01932 ENOG4108FKH Transglycosylase SLT domain S101395_01933 ENOG4108WZM domain protein S101395_01934 ENOG4105X7F S101395_01936 ENOG4105MFU Protein of unknown function (DUF2634) S101395_01937 ENOG41066EA baseplate J family protein S101395_01938 ENOG410906S phage-like element pbsx protein xkdt S101395_01955 ENOG4106855 Competence protein S101395_01963 ENOG4105VFR signal peptidase S101395_01968 ENOG4105C0D helicase S101395_01969 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) S101395_01971 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor S101395_01972 ENOG4105WZW rhodanese family S101395_01973 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) S101395_01974 ENOG4105KST dependent repressor S101395_01977 ENOG4105CBJ Metal-dependent enzyme S101395_01979 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) S101395_01980 ENOG4105DC7 peptidase M24 S101395_01981 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) S101395_01983 ENOG4105CD2 stage iii sporulation protein aa S101395_01984 ENOG4105KR5 Stage iii sporulation protein S101395_01985 ENOG4108CQH stage III sporulation protein AC S101395_01986 ENOG4105KQ4 Stage iii sporulation protein ad S101395_01988 ENOG410644B Stage III sporulation protein af S101395_01992 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S101395_01993 ENOG4108ZSR alkaline shock protein S101395_01994 ENOG4105M7K Involved in the transcription termination process (By similarity) S101395_01995 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) S101395_01996 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S101395_01997 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) S101395_01998 ENOG4105CTB Polyprenyl synthetase S101395_01999 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) S101395_02000 ENOG4105DX0 Hemolysin A S101395_02001 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) S101395_02002 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) S101395_02003 ENOG4105S1Z Stage IV sporulation protein B S101395_02004 ENOG4107QQR Sporulation S101395_02008 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A S101395_02010 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase S101395_02011 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101395_02012 ENOG4106CCJ Protein of unknown function (DUF2627) S101395_02013 ENOG4108JUB Transcriptional regulator S101395_02015 ENOG4107RDP Dehydrogenase S101395_02016 ENOG4105CKM Branched-chain carboxylic acid kinase S101395_02019 ENOG4105CPP Dehydrogenase, E1 component S101395_02020 ENOG4105C7S Dehydrogenase S101395_02021 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) S101395_02022 ENOG4108Y6J UPF0403 protein S101395_02023 ENOG4108HW3 (ABC) transporter S101395_02024 ENOG4105E5Q amino acid AbC transporter S101395_02025 ENOG4105CDA abc transporter atp-binding protein S101395_02026 ENOG4108QEG Membrane S101395_02027 ENOG4108HNZ carboxyl transferase S101395_02028 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) S101395_02030 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) S101395_02032 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101395_02033 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S101395_02034 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S101395_02035 ENOG4105G6Z alkaline phosphatase S101395_02036 ENOG4105VZJ PTS System S101395_02037 ENOG4105VCP PTS System S101395_02038 ENOG4105CK1 PTS System S101395_02039 ENOG4105CS2 ec 3.2.1.21 S101395_02041 ENOG4108TZY GntR Family Transcriptional Regulator S101395_02045 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase S101395_02046 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) S101395_02047 ENOG4105WDJ 50S ribosomal protein L33 S101395_02049 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101395_02051 ENOG4105II7 pyrroline-5-carboxylate reductase S101395_02052 ENOG41069FQ Metallo-beta-lactamase superfamily S101395_02053 ENOG4108IXY short-chain dehydrogenase reductase S101395_02054 ENOG4105K7W phage-related replication protein S101395_02066 ENOG4108M15 ABC transporter S101395_02069 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase S101395_02070 ENOG4105E5W Transporter S101395_02074 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) S101395_02078 ENOG4107R73 Mate efflux family protein S101395_02080 ENOG4108RZA ABC transporter S101395_02081 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101395_02082 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101395_02083 ENOG4107RRN ABC transporter substrate-binding protein S101395_02085 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold S101395_02087 ENOG4108XET gCN5-related N-acetyltransferase S101395_02088 ENOG4105KAC Antibiotic biosynthesis monooxygenase S101395_02089 ENOG4105RHY Pfam:UPF0157 S101395_02091 ENOG4106HZJ S101395_02095 ENOG4105CPC Aldo Keto reductase S101395_02097 ENOG4105PF9 Transcriptional regulator S101395_02099 ENOG4108YZ4 nudix hydrolase S101395_02101 ENOG4107YB6 acetyltransferase, (GNAT) family S101395_02104 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease S101395_02106 ENOG4105CK1 PTS System S101395_02107 ENOG4105MZ9 stage II sporulation protein m S101395_02108 ENOG4105I3K Ferric uptake regulator, Fur family S101395_02110 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101395_02111 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) S101395_02112 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) S101395_02113 ENOG4105DZ1 carboxypeptidase S101395_02114 ENOG41082AN stage II sporulation protein S101395_02115 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) S101395_02116 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101395_02119 ENOG41090VF Stage v sporulation protein ac S101395_02120 ENOG4105CZ3 stage V sporulation protein ad S101395_02122 ENOG4105G6R Stage v sporulation protein ae S101395_02125 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) S101395_02126 ENOG4105K7W phage-related replication protein S101395_02127 ENOG4105PTM secreted protein S101395_02128 ENOG4107ZE5 PPIases accelerate the folding of proteins S101395_02131 ENOG4105MYT Heat shock protein S101395_02134 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) S101395_02135 ENOG4108R6K riboflavin synthase, subunit alpha S101395_02136 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) S101395_02137 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) S101395_02141 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) S101395_02142 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) S101395_02144 ENOG4105DZ1 carboxypeptidase S101395_02145 ENOG4108JIC nucleoside recognition domain protein S101395_02147 ENOG4105FE9 pseudouridine synthase S101395_02148 ENOG4108IFH alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101395_02149 ENOG4107TWT Cytochrome c biogenesis protein S101395_02150 ENOG4105CRE cytochrome C S101395_02151 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101395_02152 ENOG4105BZU Histidine kinase S101395_02153 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101395_02154 ENOG4105US7 Histidine kinase S101395_02157 ENOG4108KGH TRANSCRIPTIONal S101395_02160 ENOG4105DR5 peptidase S101395_02161 ENOG4108JQ1 Dehydrogenase S101395_02162 ENOG4108SAX Membrane S101395_02164 ENOG4105T7X S101395_02165 ENOG4105C9U ATP-dependent DNA helicase RecQ S101395_02166 ENOG4105I7S Abortive infection protein S101395_02169 ENOG4107RGJ metallophosphoesterase S101395_02172 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase S101395_02173 ENOG4105HDK L-asparaginase S101395_02176 ENOG4105MSI germination protein ypeb S101395_02178 ENOG4105CAT Cytidine monophosphate kinase S101395_02179 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) S101395_02180 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) S101395_02182 ENOG4105S2F S101395_02183 ENOG41065D1 S101395_02184 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) S101395_02185 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase S101395_02188 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) S101395_02189 ENOG4105K70 DNA-binding protein S101395_02190 ENOG4105EUJ GTP cyclohydrolase i S101395_02192 ENOG4105XXQ heptaprenyl diphosphate synthase component I S101395_02193 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) S101395_02194 ENOG4105EAH synthase S101395_02195 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) S101395_02196 ENOG4105BZU Histidine kinase S101395_02197 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase S101395_02198 ENOG4105D49 3-dehydroquinate synthase S101395_02199 ENOG4105KHN chorismate mutase S101395_02201 ENOG4105CRQ synthase (Component I) S101395_02202 ENOG4108I0Q anthranilate phosphoribosyltransferase S101395_02203 ENOG4105DK0 Indole-3-glycerol phosphate synthase S101395_02205 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) S101395_02206 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) S101395_02207 ENOG4105CIH Imidazole acetol-phosphate transaminase S101395_02210 ENOG41068YB TPR repeat-containing protein S101395_02211 ENOG4108SXZ UPF0302 protein S101395_02214 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) S101395_02218 ENOG4108JYZ YitT family S101395_02219 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase S101395_02220 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) S101395_02221 ENOG4108Z5K methylglyoxal synthase S101395_02222 ENOG4105FJR Lmbe family S101395_02223 ENOG4105CPK Glycosyl transferase (Group 1 S101395_02224 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate S101395_02226 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) S101395_02227 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) S101395_02228 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) S101395_02229 ENOG4105DVT helicase S101395_02230 ENOG4105YAC S101395_02232 ENOG4105CHM Aminotransferase S101395_02236 ENOG4105CSM endonuclease III S101395_02238 ENOG4105BZ4 penicillin-binding protein S101395_02247 ENOG4108I5C dEAD DEAH box helicase S101395_02248 ENOG4107X2U Inherit from COG: Exonuclease-like protein S101395_02251 ENOG4108UKS UPF0398 protein S101395_02252 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) S101395_02253 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) S101395_02256 ENOG4105DVT helicase S101395_02257 ENOG4105CTD carboxy-peptidase S101395_02258 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) S101395_02259 ENOG4105C2W permease S101395_02260 ENOG4105WCN acetyltransferase S101395_02261 ENOG41065KQ synthase S101395_02263 ENOG410890F Dynamin family S101395_02268 ENOG41081VK Ribonuclease S101395_02276 ENOG4108QBV Monogalactosyldiacylglycerol synthase S101395_02277 ENOG4105CVG Homoserine O-transsuccinylase S101395_02278 ENOG4105CKU formyltetrahydrofolate synthetase S101395_02279 ENOG4108V06 Glutathione peroxidase S101395_02282 ENOG4105C01 Dihydroxy-acid dehydratase S101395_02284 ENOG4107YX5 Pfam:DUF548 S101395_02287 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) S101395_02289 ENOG4108UT2 hemolysin iii S101395_02291 ENOG4105C7B Threonine dehydratase S101395_02293 ENOG4108RCR degv family S101395_02294 ENOG4108KF3 Electron transport protein SCO1 SenC S101395_02295 ENOG41090WU lipolytic protein G-D-S-L family S101395_02296 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) S101395_02303 ENOG4105E0X reductase S101395_02305 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101395_02308 ENOG4107S4Y M20 DapE family protein YgeY S101395_02309 ENOG4108TSC N-acetyltransferase S101395_02310 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein S101395_02312 ENOG4105VSD UPF0346 protein S101395_02316 ENOG410841Q phosphoesterase PA-phosphatase related protein S101395_02317 ENOG4106Z5R S101395_02320 ENOG4108PJD permease S101395_02321 ENOG4105D3A purine nucleoside phosphorylase DeoD-type S101395_02322 ENOG4108VXD carboxy-peptidase S101395_02326 ENOG4105E1V na solute symporter S101395_02329 ENOG4105FBA Phospholipase Carboxylesterase S101395_02332 ENOG4107EXU Short-chain dehydrogenase reductase Sdr S101395_02334 ENOG4108YQE rare lipoprotein a S101395_02336 ENOG4105FR1 rard protein S101395_02342 ENOG4105K4H Nlp p60 protein S101395_02344 ENOG4105GMT ATPase associated with various cellular activities aaa_5 S101395_02345 ENOG4107T89 von Willebrand factor, type A S101395_02346 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 S101395_02347 ENOG4105C7S Dehydrogenase S101395_02348 ENOG4105C09 Bile acid S101395_02349 ENOG4105C8J )-transporter S101395_02350 ENOG4105C8J )-transporter S101395_02351 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) S101395_02352 ENOG4105EWU Squalene--hopene cyclase S101395_02353 ENOG4105EWU Squalene--hopene cyclase S101395_02356 ENOG4105CPC Aldo Keto reductase S101395_02360 ENOG4105C26 Dehydrogenase S101395_02363 ENOG4105F0F Oxalate decarboxylase S101395_02364 ENOG4105SCY DNAK suppressor S101395_02365 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) S101395_02372 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) S101395_02374 ENOG4108IUW ABC transporter S101395_02377 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) S101395_02378 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S101395_02380 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S101395_02383 ENOG4105ST3 Transcriptional regulator S101395_02385 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S101395_02386 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S101395_02387 ENOG410829K Lysine exporter protein (Lyse ygga) S101395_02390 ENOG4105DDN Pentapeptide repeat-containing protein S101395_02391 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101395_02398 ENOG41090VF Stage v sporulation protein ac S101395_02399 ENOG4105CZ3 stage V sporulation protein ad S101395_02402 ENOG4108QY0 Membrane S101395_02407 ENOG4105I1F Resistance protein S101395_02408 ENOG4105VUF Transcriptional regulator S101395_02409 ENOG4105EMU Dehydrogenase S101395_02412 ENOG4108ZMX Domain of unknown function (DU1801) S101395_02420 ENOG4105C9U ATP-dependent DNA helicase RecQ S101395_02421 ENOG41069ER domain protein S101395_02422 ENOG4107RUZ Sss sodium solute transporter superfamily S101395_02424 ENOG4108SJC Membrane S101395_02425 ENOG4107T8Q Glycosyl transferase (Group 1 S101395_02428 ENOG4105C5E polysaccharide biosynthesis protein S101395_02430 ENOG4105CUB amino acid S101395_02433 ENOG4105KTU Transcriptional regulator, arsr family S101395_02435 ENOG4105D29 Helix-turn-helix type 11 domain protein S101395_02438 ENOG4108W8B Beta-lactamase domain protein S101395_02441 ENOG4108RZE Tetr family transcriptional regulator S101395_02443 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101395_02445 ENOG4108Z7R Chaperone CsaA S101395_02446 ENOG4105C8Q Methyl-accepting chemotaxis S101395_02448 ENOG4105E1K spore germination protein S101395_02453 ENOG4108Q8B Spore germination protein S101395_02454 ENOG4108Q8B Spore germination protein S101395_02455 ENOG4108NHD germination protein S101395_02456 ENOG4108Q8B Spore germination protein S101395_02457 ENOG4108Q8B Spore germination protein S101395_02460 ENOG4105I03 Flagellin S101395_02461 ENOG4108J2R molybdopterin oxidoreductase S101395_02462 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101395_02465 ENOG4105DGI Alkaline phosphatase S101395_02466 ENOG4105BZ1 (ABC) transporter S101395_02472 ENOG4105C5Q Transcriptional regulator S101395_02473 ENOG4105CBC glutamate synthase S101395_02474 ENOG4105BZ8 glutamate synthase S101395_02478 ENOG4107RCC Major Facilitator Superfamily S101395_02479 ENOG4105DIA mandelate racemase muconate lactonizing S101395_02481 ENOG41061P3 phosphosulfolactate synthase S101395_02482 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S101395_02484 ENOG4107RIQ Sulfate adenylate transferase S101395_02485 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) S101395_02486 ENOG4105H67 Protein of unknown function (DUF421) S101395_02487 ENOG4105II7 pyrroline-5-carboxylate reductase S101395_02488 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S101395_02489 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) S101395_02490 ENOG4105C1G acyl-Coa dehydrogenase S101395_02491 ENOG4105CEY Amp-dependent synthetase and ligase S101395_02492 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase S101395_02493 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit S101395_02494 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase S101395_02495 ENOG4105E39 Enoyl-CoA hydratase S101395_02496 ENOG4107QX3 carboxylase S101395_02497 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) S101395_02502 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family S101395_02503 ENOG4105C6N Formate acetyltransferase S101395_02504 ENOG4105F1A Pyruvate formate-lyase S101395_02506 ENOG4105F32 YngK protein S101395_02507 ENOG4105CSC Glucose uptake protein S101395_02509 ENOG41082YX Transcriptional regulator, arsr family S101395_02510 ENOG4107R5R arsenical pump membrane protein S101395_02511 ENOG4108UXE Protein tyrosine phosphatase S101395_02512 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S101395_02518 ENOG4105VCH membrane S101395_02519 ENOG4107QIV Cytochrome c biogenesis protein S101395_02520 ENOG41060BG Tetr family transcriptional regulator S101395_02522 ENOG4107E54 Small Multidrug Resistance protein S101395_02524 ENOG4105DM4 PTS System S101395_02525 ENOG4105DG6 mannose-6-phosphate isomerase S101395_02526 ENOG410904A RNA polymerase S101395_02527 ENOG4105CPC Aldo Keto reductase S101395_02528 ENOG4105C1G acyl-Coa dehydrogenase S101395_02529 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S101395_02530 ENOG4105C26 Dehydrogenase S101395_02531 ENOG41060WC Enoyl-CoA hydratase S101395_02539 ENOG4108IUE nitrate reductase beta subunit S101395_02540 ENOG4105R3A Nitrate reductase S101395_02543 ENOG4108IJ8 ABC transporter S101395_02544 ENOG4105E90 ABC transporter S101395_02546 ENOG4107U9B transcriptional regulator S101395_02547 ENOG4108UMN azlc family S101395_02548 ENOG4105KMT branched-chain amino acid S101395_02554 ENOG4105GPN Uncharacterized conserved protein (DUF2294) S101395_02555 ENOG4108TWJ NADH dehydrogenase subunit 5 S101395_02556 ENOG4105EVH UPF0753 protein S101395_02559 ENOG4105ENX hydrolase S101395_02564 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component S101395_02565 ENOG4105E2Y ABC, transporter S101395_02566 ENOG4108428 Inherit from COG: -acetyltransferase S101395_02568 ENOG4107QWR cellulase (EC 3.2.1.4) S101395_02569 ENOG4106U2H Protein of unknown function (DUF1360) S101395_02570 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) S101395_02571 ENOG4105DSQ Nitric oxide reductase S101395_02575 ENOG4107V6Q Cyclic nucleotide-binding domain S101395_02581 ENOG4108IUE nitrate reductase beta subunit S101395_02582 ENOG4105R3A Nitrate reductase S101395_02589 ENOG4105CHR reductase S101395_02590 ENOG4107QNK )-transporter S101395_02591 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) S101395_02594 ENOG4105CMD Transcriptional regulator, GntR family S101395_02596 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) S101395_02597 ENOG4105K4P CoA-binding domain protein S101395_02598 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) S101395_02599 ENOG4105W8X HesB YadR YfhF-family protein S101395_02600 ENOG4105MI2 S101395_02602 ENOG41067CD Small, acid-soluble spore protein Tlp S101395_02605 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101395_02606 ENOG4108I0Z Aconitate hydratase S101395_02607 ENOG41076DU acid-soluble spore protein P S101395_02612 ENOG4107QIV Cytochrome c biogenesis protein S101395_02614 ENOG4105VXM UPF0154 protein S101395_02616 ENOG4105CV1 Transketolase (EC 2.2.1.1) S101395_02617 ENOG4105VPS UPF0291 protein S101395_02618 ENOG4108SVB resolvase S101395_02620 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) S101395_02622 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) S101395_02627 ENOG41062JF Transcriptional regulator S101395_02630 ENOG4105WEF catalase S101395_02630 ENOG4105WEF catalase S101395_02633 ENOG4108MK9 spermidine N(1)-acetyltransferase S101395_02642 ENOG4107QM2 Aldo Keto reductase S101395_02645 ENOG4105CHR reductase S101395_02653 ENOG4105DQ4 alcohol dehydrogenase S101395_02656 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S101395_02659 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S101395_02662 ENOG4107S91 Sodium hydrogen exchanger S101395_02663 ENOG4105NCW Trka-c domain protein S101395_02673 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) S101395_02678 ENOG4105F3R pts system mannose fructose sorbose family iid S101395_02679 ENOG4105ETZ PTS System S101395_02685 ENOG4105K59 histidine triad (HIT) protein S101395_02686 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S101395_02689 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S101395_02719 ENOG4105VTR Integrase S101395_02720 ENOG4105C5F glutamine synthetase S101395_02721 ENOG4105KV4 Transcriptional regulator S101395_02722 ENOG4105CXI aluminum resistance protein S101395_02723 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) S101395_02724 ENOG4106F1P AAA ATPase, central domain protein S101395_02727 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) S101395_02736 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) S101395_02739 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S101395_02743 ENOG4106ITI Glutaredoxin S101395_02744 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_02746 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_02747 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_02748 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S101395_02769 ENOG4106J9J DNA polymerase S101395_02771 ENOG4106J9J DNA polymerase S101395_02773 ENOG4106IVX S101395_02774 ENOG4106PTB DnaB-like helicase C terminal domain S101395_02776 ENOG41088HM S101395_02777 ENOG4106YR8 S101395_02792 ENOG4108J9Q DNA ligase S101395_02804 ENOG4105GJD protein, conserved in bacteria S101395_02820 ENOG4107D0N S101395_02833 ENOG4107NTZ S101395_02848 ENOG4108NE4 S101395_02853 ENOG4105K59 histidine triad (HIT) protein S101395_02854 ENOG4105FDK ABC transporter S101395_02862 ENOG4106QVS S101395_02881 ENOG41068G1 S101395_02900 ENOG4105E4C Lytic transglycosylase catalytic S101395_02901 ENOG4105E4C Lytic transglycosylase catalytic S101395_02902 ENOG4105E4C Lytic transglycosylase catalytic S101395_02908 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase S101395_02916 ENOG4106ANW SMI1_KNR4 S101395_02919 ENOG4107EV6 Inherit from COG: YD repeat protein S101395_02925 ENOG4106F1P AAA ATPase, central domain protein S101395_02930 ENOG4105DRR Transcriptional regulator, GntR family S101395_02931 ENOG4105U6W MutT NUDIX family protein S101395_02932 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_02933 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_02934 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S101395_02936 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) S101395_02937 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) S101395_02941 ENOG4107E54 Small Multidrug Resistance protein S101395_02942 ENOG4108X3M OsmC Ohr family protein S101395_02944 ENOG4107S9F NmrA family S101395_02945 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein S101395_02946 ENOG4105M4P Tetr family transcriptional regulator S101395_02947 ENOG4105VRS hydrolase family 18 S101395_02950 ENOG4107QTZ amino acid S101395_02951 ENOG41087PP glycosyltransferase MGT family S101395_02952 ENOG4108A04 Beta-lactamase S101395_02953 ENOG41080BT SNARE associated Golgi S101395_02960 ENOG4105U6C Alpha beta hydrolase fold protein S101395_02961 ENOG4108J8C transporter major facilitator family protein S101395_02963 ENOG4105CEY Amp-dependent synthetase and ligase S101395_02964 ENOG4105C0W non-ribosomal peptide synthetase S101395_02966 ENOG4105C0W non-ribosomal peptide synthetase S101395_02967 ENOG4105C0W non-ribosomal peptide synthetase S101395_02968 ENOG4105C0W non-ribosomal peptide synthetase S101395_02970 ENOG4105C3N Participates in control of cell volume in low-osmolarity conditions (By similarity) S101395_02971 ENOG4105XPP Protein of unknown function (DUF1275) S101395_02974 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase S101395_02975 ENOG4108RAV Conserved protein S101395_02987 ENOG4106BHF S101395_02988 ENOG4107EV6 Inherit from COG: YD repeat protein S101395_02989 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase S101395_03006 ENOG4108S9F abc transporter, atp-binding protein S101395_03007 ENOG4108RZA ABC transporter S101395_03008 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101395_03009 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101395_03010 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein S101395_03015 ENOG4105CKI cobalamin synthesis protein S101395_03016 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S101395_03017 ENOG4105NZG Ferredoxin S101395_03018 ENOG4105CKI cobalamin synthesis protein S101395_03019 ENOG4108UNV SUF system FeS assembly protein, NifU family S101395_03023 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) S101395_03024 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) S101395_03027 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) S101395_03028 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) S101395_03029 ENOG4105CPQ Dehydrogenase S101395_03030 ENOG4108IGT Dipeptidase S101395_03031 ENOG4105MCT stage V sporulation protein S S101395_03032 ENOG4105D48 metallophosphoesterase S101395_03033 ENOG4105D48 metallophosphoesterase S101395_03035 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) S101395_03036 ENOG4105CEV competence damage-inducible protein S101395_03037 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase S101395_03040 ENOG4105XZV Protein of unknown function (DUF3243) S101395_03041 ENOG4108RKS Short-chain dehydrogenase reductase Sdr S101395_03045 ENOG4105FDP GntR family transcriptional regulator S101395_03046 ENOG4105CNU cell division protein FtsK S101395_03048 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit S101395_03050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) S101395_03052 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) S101395_03053 ENOG4108S0H Dipicolinic acid synthetase, b subunit S101395_03054 ENOG4105E35 Dipicolinate synthase subunit A S101395_03056 ENOG4105C1V Peptidase, M16 S101395_03058 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) S101395_03059 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) S101395_03060 ENOG4105DTN riboflavin biosynthesis protein ribF S101395_03061 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) S101395_03062 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) S101395_03063 ENOG4105W7A Protein of unknown function (DUF503) S101395_03064 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) S101395_03065 ENOG4105VHM ribosomal protein S101395_03066 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination S101395_03067 ENOG4105CHV Transcription elongation factor NusA S101395_03068 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) S101395_03071 ENOG4105CYP glycoside hydrolase, family S101395_03073 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) S101395_03075 ENOG4105DZP Membrane-associated zinc metalloprotease S101395_03077 ENOG4105KNE Phosphatidate cytidylyltransferase S101395_03078 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) S101395_03079 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) S101395_03081 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) S101395_03082 ENOG4105CE9 30S ribosomal protein S2 S101395_03084 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101395_03085 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) S101395_03087 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis S101395_03088 ENOG4105CBS Chea signal transduction histidine kinase S101395_03089 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) S101395_03091 ENOG4105FZW flagellar biosynthesis regulator FlhF S101395_03092 ENOG4105D7B Flagellar biosynthesis protein flha S101395_03093 ENOG4105D00 flagellar biosynthetic protein flhB S101395_03094 ENOG4105D19 Role in flagellar biosynthesis (By similarity) S101395_03095 ENOG4105VS8 Flagellar biosynthetic protein fliq S101395_03096 ENOG4105CN7 Flagellar biosynthetic protein FliP S101395_03098 ENOG4107YTP response regulator receiver protein S101395_03099 ENOG4105DD5 Flagellar motor switch protein S101395_03100 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S101395_03102 ENOG4108JQA flagellar S101395_03103 ENOG410822I Flagellar hook capping protein S101395_03104 ENOG410696Y Flagellar hook-length control protein S101395_03106 ENOG4106YF4 Flagellar biosynthesis chaperone S101395_03107 ENOG4106YF4 Flagellar biosynthesis chaperone S101395_03110 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) S101395_03111 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) S101395_03112 ENOG4105VQ0 flagellar hook-basal body complex protein fliE S101395_03113 ENOG4108ZC9 flagellar basal-body rod protein flgc S101395_03114 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) S101395_03116 ENOG4105EUM DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity) S101395_03117 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) S101395_03118 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) S101395_03119 ENOG4108HE4 integrase family S101395_03120 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) S101395_03121 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) S101395_03122 ENOG4105C79 DNA protecting protein DprA S101395_03123 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha S101395_03124 ENOG4105CMV Succinyl-CoA synthetase subunit beta S101395_03125 ENOG4105VM1 flagellar S101395_03127 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) S101395_03128 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) S101395_03129 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) S101395_03130 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) S101395_03131 ENOG4107Z8R An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) S101395_03133 ENOG4108BW8 UPF0109 protein S101395_03134 ENOG4105K5M 30s ribosomal protein S16 S101395_03136 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) S101395_03137 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) S101395_03138 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) S101395_03139 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) S101395_03140 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) S101395_03141 ENOG4105CHR reductase S101395_03142 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase S101395_03143 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) S101395_03144 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) S101395_03145 ENOG4105CB5 ATP-dependent DNA helicase recG S101395_03146 ENOG4105EJQ L-serine dehydratase S101395_03148 ENOG4105DP4 dak2 domain fusion protein ylov S101395_03149 ENOG4108ZAA Alkaline-shock protein S101395_03150 ENOG4105VB9 50S ribosomal protein l28 S101395_03151 ENOG4105FJ0 thiamine S101395_03152 ENOG4105DJV ribulose-phosphate 3-epimerase S101395_03153 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) S101395_03154 ENOG4105D9P serine threonine protein kinase S101395_03155 ENOG4108ZF3 Phosphatase S101395_03156 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs S101395_03157 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B S101395_03158 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) S101395_03159 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101395_03160 ENOG4105C25 Primosomal protein n' S101395_03161 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase S101395_03162 ENOG4105ZAD Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) S101395_03163 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) S101395_03164 ENOG4105KC4 UPF0296 protein S101395_03165 ENOG4105DSJ YicC domain protein S101395_03168 ENOG4105F23 Fibronectin-binding protein S101395_03169 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein S101395_03170 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein S101395_03171 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S101395_03175 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) S101395_03179 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) S101395_03180 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) S101395_03181 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) S101395_03182 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain S101395_03183 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S101395_03184 ENOG4105CD3 dihydroorotase S101395_03185 ENOG4105CXT aspartate transcarbamylase S101395_03187 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) S101395_03188 ENOG4105C34 Pseudouridine synthase S101395_03189 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) S101395_03193 ENOG4105DBK s4 domain protein S101395_03194 ENOG41067XK integral membrane protein S101395_03195 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) S101395_03196 ENOG4105DFA alanine racemase domain protein S101395_03197 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase S101395_03198 ENOG4105WR5 sporulation protein, YlmC YmxH family S101395_03199 ENOG4105DHI Methyltransferase S101395_03201 ENOG4105DKW ABC transporter S101395_03203 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) S101395_03204 ENOG4105FFI sigma-e processing peptidase spoiiga S101395_03207 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) S101395_03208 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) S101395_03209 ENOG4105K67 small basic protein S101395_03211 ENOG4108R2U division initiation protein S101395_03212 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) S101395_03213 ENOG4105D4A Cell wall formation (By similarity) S101395_03214 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) S101395_03215 ENOG4105CNI cell division protein FtsW S101395_03216 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) S101395_03217 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) S101395_03218 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) S101395_03219 ENOG4105CJN penicillin-binding protein S101395_03220 ENOG4105CJN penicillin-binding protein S101395_03222 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) S101395_03223 ENOG4108V6E Cell division protein mraZ S101395_03224 ENOG41074B2 UPF0747 protein S101395_03228 ENOG41067VY 50S ribosomal protein L32 S101395_03229 ENOG4105KNH Nucleic acid-binding protein S101395_03230 ENOG4105CDE UPF0348 protein S101395_03231 ENOG41063PX domain protein S101395_03232 ENOG4105H20 Sporulation integral membrane protein YlbJ S101395_03233 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) S101395_03234 ENOG4106H78 methyltransferase S101395_03240 ENOG4105CE7 Amidase, hydantoinase carbamoylase family S101395_03241 ENOG4107QN1 sodium solute S101395_03242 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family S101395_03243 ENOG4106UY4 Inherit from COG: Scp-like extracellular S101395_03244 ENOG41080XQ Signal transduction protein with cbs domains S101395_03247 ENOG41064X9 cytochrome C oxidase subunit IV S101395_03248 ENOG4105CCU oxidase (Subunit III) S101395_03249 ENOG4105BZ9 Cytochrome C oxidase, subunit I S101395_03251 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) S101395_03253 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) S101395_03254 ENOG4105CNI cell division protein FtsW S101395_03255 ENOG4105ZPI UPF0358 protein S101395_03256 ENOG4105CSV Glutaminase S101395_03258 ENOG4108IAB Phoh family S101395_03261 ENOG4107SCK Monooxygenase S101395_03262 ENOG4108INS Transcriptional regulator S101395_03263 ENOG4105QA2 S101395_03264 ENOG4105CI3 gtp-binding protein typa S101395_03267 ENOG4105ECY inositol monophosphatase S101395_03269 ENOG4105WBI UPF0223 protein S101395_03270 ENOG4105CXN decarboxylase S101395_03273 ENOG4107QN2 dihydrolipoyl dehydrogenase S101395_03274 ENOG4105C7S Dehydrogenase S101395_03275 ENOG4105CPP Dehydrogenase, E1 component S101395_03279 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101395_03280 ENOG4108X4Q Hydrolase S101395_03281 ENOG4108X4Q Hydrolase S101395_03283 ENOG4105CN5 Metallo-Beta-Lactamase S101395_03285 ENOG4107ZYR domain protein S101395_03286 ENOG4105BZU Histidine kinase S101395_03292 ENOG4105C5H ABC transporter S101395_03295 ENOG4105C3F Signal peptidase i S101395_03296 ENOG4105DM4 PTS System S101395_03297 ENOG4105DE4 1-phosphofructokinase S101395_03298 ENOG4105E98 transcriptional regulator DeoR family S101395_03301 ENOG4107RBB ABC transporter, permease S101395_03302 ENOG4105C19 ABC transporter S101395_03303 ENOG4107X8C Efflux transporter RND family MFP subunit S101395_03305 ENOG4105BZ1 (ABC) transporter S101395_03306 ENOG4105BZ1 (ABC) transporter S101395_03308 ENOG41067WU Molybdopterin converting factor (Subunit 1) S101395_03309 ENOG4108ZAF Molybdopterin S101395_03310 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein S101395_03311 ENOG4105CVM Molybdenum cofactor synthesis domain protein S101395_03312 ENOG4105D06 uba thif-type nad fad binding protein S101395_03313 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) S101395_03316 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen S101395_03317 ENOG4105D3R alkyl hydroperoxide reductase S101395_03320 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) S101395_03321 ENOG4105NQC Flavodoxin S101395_03327 ENOG4108XRC Protein of unknown function (DUF458) S101395_03329 ENOG4107IN1 Protein of unknown function (DUF1797) S101395_03332 ENOG4105EPM Diguanylate phosphodiesterase S101395_03333 ENOG4105K6S Short-chain dehydrogenase reductase Sdr S101395_03335 ENOG4108QQZ ErfK YbiS YcfS YnhG family protein S101395_03337 ENOG4105UIN S101395_03338 ENOG4107R88 Chemotaxis protein (CheV) S101395_03340 ENOG41085PJ rdd domain containing protein S101395_03342 ENOG4105CHM Aminotransferase S101395_03343 ENOG4105BZU Histidine kinase S101395_03344 ENOG4105BZU Histidine kinase S101395_03346 ENOG4105K4I Scp-like extracellular S101395_03347 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase S101395_03348 ENOG4105CHR reductase S101395_03349 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer S101395_03351 ENOG4105F6S Spore photoproduct lyase S101395_03353 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) S101395_03354 ENOG4105KRI phosphocarrier protein (HPr S101395_03356 ENOG4105CID antiterminator S101395_03360 ENOG4105DC7 peptidase M24 S101395_03361 ENOG4105C59 p-type ATPase S101395_03364 ENOG4105F0V Cell wall hydrolase S101395_03368 ENOG4108YM7 Gcn5-related n-acetyltransferase S101395_03370 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein S101395_03374 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) S101395_03380 ENOG4105D29 Helix-turn-helix type 11 domain protein S101395_03383 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) S101395_03384 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) S101395_03385 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase S101395_03386 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) S101395_03387 ENOG4108K88 Membrane S101395_03389 ENOG4105E14 MotA TolQ exbB proton channel S101395_03390 ENOG4105ER2 Ompa motb domain protein S101395_03391 ENOG41090MY MarR family Transcriptional regulator S101395_03392 ENOG4105BZU Histidine kinase S101395_03393 ENOG4105BZU Histidine kinase S101395_03396 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) S101395_03397 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) S101395_03400 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate S101395_03402 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S101395_03404 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) S101395_03406 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) S101395_03407 ENOG4105BZU Histidine kinase S101395_03408 ENOG4108TGC Acyltransferase S101395_03411 ENOG4107RVG penicillin-binding protein S101395_03413 ENOG4105D0M Protease HtpX homolog S101395_03415 ENOG410681C small acid-soluble spore protein S101395_03417 ENOG4108WZW RNA polymerase sigma S101395_03418 ENOG4107TS3 membrane protein, TerC S101395_03419 ENOG4107T5V SNARE associated Golgi S101395_03420 ENOG4105BZU Histidine kinase S101395_03422 ENOG4105FDF Could be involved in DNA repair (By similarity) S101395_03423 ENOG4105DQE DNA ligase S101395_03427 ENOG4105V75 Transcriptional regulator S101395_03429 ENOG4105CJW magnesium transporter S101395_03432 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101395_03433 ENOG4107QYE Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) S101395_03437 ENOG4107Y2X deaminase S101395_03439 ENOG4108ZHJ Organic hydroperoxide resistance protein S101395_03440 ENOG4105K56 Transcriptional regulator S101395_03442 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) S101395_03443 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) S101395_03444 ENOG4105CIY formyltetrahydrofolate deformylase S101395_03445 ENOG41080TC multidrug resistance protein S101395_03446 ENOG410839T multidrug resistance protein S101395_03448 ENOG4108J20 pectate lyase S101395_03450 ENOG4108S4H thioesterase Superfamily protein S101395_03451 ENOG4107TUM Amidinotransferase S101395_03452 ENOG4108JQ7 (ABC) transporter S101395_03453 ENOG4107SN7 NLP P60 protein S101395_03454 ENOG4105DTQ mandelate racemase muconate lactonizing S101395_03455 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A S101395_03457 ENOG4105C3U ABC transporter S101395_03458 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101395_03459 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101395_03460 ENOG4108ME1 Peptidase M55 D-aminopeptidase S101395_03462 ENOG4105C0H protease S101395_03464 ENOG4107R7I amino acid S101395_03465 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component S101395_03467 ENOG4105E0S extracellular solute-binding protein family 1 S101395_03468 ENOG4105EKC S101395_03470 ENOG4107TDE lipolytic protein G-D-S-L family S101395_03471 ENOG4107TDE lipolytic protein G-D-S-L family S101395_03472 ENOG4105CX8 fg-gap repeat protein S101395_03475 ENOG4107TDE lipolytic protein G-D-S-L family S101395_03476 ENOG41075H3 AraC family transcriptional regulator S101395_03477 ENOG4105F5H Glycosyl Hydrolase Family 88 S101395_03478 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component S101395_03479 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component S101395_03480 ENOG410769Z extracellular solute-binding protein family 1 S101395_03481 ENOG4105EQD regulatoR S101395_03482 ENOG4105C2F Histidine kinase S101395_03486 ENOG4105ECW sulfate abc transporter S101395_03487 ENOG4108I5D sulfate abc transporter S101395_03488 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein S101395_03489 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) S101395_03490 ENOG4107GRR phosphate transport regulator S101395_03491 ENOG4105CJ3 phosphate transporter S101395_03494 ENOG4108I5G Major Facilitator superfamily S101395_03495 ENOG4105CPQ Dehydrogenase S101395_03496 ENOG4105DMW Dehydrogenase reductase S101395_03497 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) S101395_03498 ENOG4105CPQ Dehydrogenase S101395_03499 ENOG4107XBN GntR Family Transcriptional Regulator S101395_03511 ENOG410635T phage-like element pbsx protein S101395_03512 ENOG4105K7W phage-related replication protein S101395_03515 ENOG4108Z7R Chaperone CsaA S101395_03518 ENOG4105J7D transcriptional regulator S101395_03522 ENOG41069ER domain protein S101395_03524 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase S101395_03525 ENOG4108Q5Y Membrane S101395_03526 ENOG4108Q5Y Membrane S101395_03528 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) S101395_03529 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) S101395_03530 ENOG4105DUM transcriptional regulator, lysR family S101395_03532 ENOG4108UW5 maltose o-acetyltransferase S101395_03537 ENOG4107S9D Alpha beta hydrolase S101395_03538 ENOG4105JQZ Methyltransferase S101395_03539 ENOG4105C01 Dihydroxy-acid dehydratase S101395_03541 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase S101395_03545 ENOG4108Z66 YbaK ebsC protein S101395_03547 ENOG4105DQ6 Transposase S101395_03552 ENOG4106ANW SMI1_KNR4 S101395_03553 ENOG4106ANW SMI1_KNR4 S101395_03554 ENOG4106BHF S101395_03556 ENOG4107EV6 Inherit from COG: YD repeat protein S101395_03561 ENOG4105JHY Membrane S101395_03562 ENOG4105C28 cystathionine S101395_03563 ENOG4105C28 cystathionine S101395_03565 ENOG4108ZMI UPF0477 protein S101395_03568 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase S101395_03569 ENOG4105CMR udp-glucose 4-epimerase S101395_03570 ENOG4107T5V SNARE associated Golgi S101395_03572 ENOG4105ENA helicase S101395_03582 ENOG4107A88 S101395_03583 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH S101395_03584 ENOG4105DWF phosphomethylpyrimidine kinase S101395_03585 ENOG4105D06 uba thif-type nad fad binding protein S101395_03586 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) S101395_03589 ENOG4108VEU Thiamine monophosphate synthase S101395_03590 ENOG4105ETU transcriptional activator (TenA S101395_03592 ENOG4107S1Q Phosphatase S101395_03593 ENOG4105EMS pseudouridine synthase S101395_03594 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) S101395_03596 ENOG4106EFP UPF0738 protein S101395_03597 ENOG4105MIX Adenylate cyclase S101395_03598 ENOG4105E4C Lytic transglycosylase catalytic S101395_03599 ENOG4108Z18 K06886 hemoglobin S101395_03600 ENOG4105T58 Dithiol-disulfide isomerase S101395_03602 ENOG4105DPN Oligoendopeptidase f S101395_03604 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis S101395_03605 ENOG4108ZCF integral membrane protein S101395_03606 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) S101395_03608 ENOG4108JQ7 (ABC) transporter S101395_03610 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101395_03611 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component S101395_03612 ENOG4108J59 Extracellular solute-binding protein, family 5 S101395_03613 ENOG4105C31 Tryptophanyl-tRNA synthetase S101395_03615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component S101395_03618 ENOG4108JQ7 (ABC) transporter S101395_03619 ENOG4105C3U ABC transporter S101395_03621 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) S101395_03622 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) S101395_03625 ENOG4107RMD Basic membrane lipoprotein S101395_03630 ENOG4105DBV ornithine carbamoyltransferase S101395_03632 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain S101395_03633 ENOG4105C8Y Acetylornithine aminotransferase S101395_03634 ENOG4105CAS nag kinase S101395_03635 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) S101395_03636 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase S101395_03638 ENOG4105VG1 fes assembly suf system protein S101395_03639 ENOG4108MXZ Esterase S101395_03640 ENOG4108KP7 hydrolase S101395_03641 ENOG41073B9 S101395_03642 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) S101395_03644 ENOG4107AYK membrAne S101395_03645 ENOG4105EPR degv family S101395_03647 ENOG4105QNR S1 RNA binding domain protein S101395_03648 ENOG4108VPT UPF0234 protein S101395_03655 ENOG4105DY8 decarboxylase S101395_03657 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101395_03658 ENOG4108ZUB Lysine exporter protein (Lyse ygga) S101395_03659 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101395_03660 ENOG4105ETE Transcriptional regulator (LacI family S101395_03662 ENOG4106HBX Transcriptional Regulator AraC Family S101395_03663 ENOG4105UQX Mate efflux family protein S101395_03664 ENOG4105CAQ asparagine synthetase S101395_03668 ENOG4105ERH Fumarylacetoacetate hydrolase S101395_03672 ENOG410751J S101395_03678 ENOG4105EYH Exonuclease S101395_03680 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation S101395_03682 ENOG4105E0C molybdate abc transporter S101395_03683 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein S101395_03685 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101395_03686 ENOG4105BZU Histidine kinase S101395_03687 ENOG41073R8 VanW family S101395_03689 ENOG4106K7D Major facilitator family transporter S101395_03690 ENOG4105CEY Amp-dependent synthetase and ligase S101395_03691 ENOG4105WEF catalase S101395_03694 ENOG4108KK1 membrane protein AbrB duplication S101395_03695 ENOG4105C5B carbamate kinase S101395_03696 ENOG4105G5A Protein of unknown function (DUF2877) S101395_03697 ENOG4107REC cytoplasmic protein S101395_03698 ENOG4107R1Q Membrane protein FdrA S101395_03699 ENOG4105DG4 malate L-lactate dehydrogenase S101395_03700 ENOG4105DG4 malate L-lactate dehydrogenase S101395_03701 ENOG4105S0E allantoin catabolism protein S101395_03702 ENOG4105CE7 Amidase, hydantoinase carbamoylase family S101395_03703 ENOG4107RNN dihydropyrimidinase (EC 3.5.2.2) S101395_03705 ENOG4105G9B Transcriptional regulator S101395_03708 ENOG4107J0C type IIi S101395_03709 ENOG4107QMH DNA methylase S101395_03711 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin S101395_03714 ENOG41060YP S101395_03715 ENOG4105XVF Competence transcription factor S101395_03719 ENOG4106YBV Methyl-accepting chemotaxis S101395_03720 ENOG4107TB6 phosphoglycerate mutase S101395_03721 ENOG4108U1V ABC transporter, permease S101395_03722 ENOG4105DQ5 transport system permease protein S101395_03723 ENOG4108HUF Transporter S101395_03724 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin S101395_03725 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 S101395_03728 ENOG4108JCI Transcriptional regulator S101395_03730 ENOG4105CEY Amp-dependent synthetase and ligase S101395_03731 ENOG4105DF9 Lipoate-protein, ligase S101395_03732 ENOG4108RQ5 Beta-lactamase domain-containing protein S101395_03733 ENOG4106AXD S101395_03736 ENOG4105DER m42 family S101395_03738 ENOG4105ECB domain protein S101395_03740 ENOG4105C1Q protoporphyrinogen oxidase S101395_03741 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) S101395_03742 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) S101395_03743 ENOG4105BZ4 penicillin-binding protein S101395_03744 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation S101395_03750 ENOG4105K59 histidine triad (HIT) protein S101395_03751 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) S101395_03752 ENOG4105NBU tryptophan transport protein S101395_03759 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) S101395_03761 ENOG4105EQI Metal Dependent Phosphohydrolase S101395_03762 ENOG4106D4I domain protein S101395_03763 ENOG4107VRP DNA repair exonuclease S101395_03764 ENOG4105RHA ABC transporter, permease S101395_03765 ENOG4108IUX (ABC) transporter S101395_03767 ENOG4105CGU Enoyl-CoA hydratase S101395_03769 ENOG4105NCW Trka-c domain protein S101395_03770 ENOG4107S91 Sodium hydrogen exchanger S101395_03771 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) S101395_03773 ENOG4105D4P Coproporphyrinogen iii oxidase S101395_03775 ENOG4105WZB UPF0342 protein S101395_03776 ENOG4106MP8 UPF0754 membrane protein S101395_03778 ENOG410839P S101395_03786 ENOG4105BZ1 (ABC) transporter S101395_03787 ENOG4105BZ1 (ABC) transporter S101395_03792 ENOG4108N2V aldose 1-epimerase S101395_03794 ENOG4105F0I Aminotransferase S101395_03795 ENOG4107VMI polysaccharide deacetylase S101395_03797 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) S101395_03798 ENOG4105D64 Mechanosensitive ion channel S101395_03800 ENOG4108QXE glycerophosphoryl diester phosphodiesterase S101395_03806 ENOG4105C37 (CBS) domain S101395_03808 ENOG4105C37 (CBS) domain S101395_03809 ENOG4105U5Y Transcriptional regulator S101395_03811 ENOG4105F6E Acyl-transferase S101395_03812 ENOG4108AEY RNA polymerase sigma factor S101395_03813 ENOG4105J37 S101395_03816 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family S101395_03817 ENOG41086D8 Transcriptional regulator S101395_03819 ENOG4105C8J )-transporter S101395_03820 ENOG4105CUB amino acid S101395_03822 ENOG4105BZN citrate synthase S101395_03826 ENOG4105ED1 spovr family S101395_03827 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) S101395_03828 ENOG4105KPV Transcriptional regulator S101395_03832 ENOG4105WH1 Two component transcriptional regulator luxr family S101395_03833 ENOG4105BZU Histidine kinase S101395_03838 ENOG4105C6V Glycerol-3-phosphate dehydrogenase S101395_03839 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S101395_03840 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S101395_03842 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator S101395_03843 ENOG4105CB2 alcohol dehydrogenase S101395_03844 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) S101395_03845 ENOG4105RK9 auxin efflux carrier S101395_03847 ENOG4105C5H ABC transporter S101395_03849 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase S101395_03850 ENOG4107YBY Hydrolase S101395_03851 ENOG41080XP Cbs domain S101395_03853 ENOG4108YBP pseudouridine synthase S101395_03854 ENOG4105R40 Glycine betaine carnitine choline S101395_03855 ENOG4108HQR Glycine betaine S101395_03856 ENOG4105E90 ABC transporter S101395_03857 ENOG4108IJ8 ABC transporter S101395_03860 ENOG4105BZU Histidine kinase S101395_03867 ENOG4107R6U sodium dicarboxylate symporter S101395_03869 ENOG4108UMI ABC transporter, permease S101395_03870 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S101395_03871 ENOG4105VEQ Cold shock protein S101395_03872 ENOG4108TU7 Inherit from COG: (ABC) transporter S101395_03873 ENOG4105CJ1 ABC, transporter S101395_03874 ENOG4105CZV ABC transporter S101395_03875 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family S101395_03878 ENOG4105CS1 NAD(P)H quinone oxidoreductase S101395_03879 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101395_03880 ENOG4105C0R drug resistance transporter emrb qaca subfamily S101395_03881 ENOG4105CW7 secretion protein, HlyD family S101395_03882 ENOG4106AKX UPF0229 protein S101395_03883 ENOG4105CYN Serine protein kinase S101395_03887 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) S101395_03889 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) S101395_03892 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) S101395_03893 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) S101395_03894 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component S101395_03895 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein S101395_03896 ENOG4105D7T ABC transporter S101395_03897 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) S101395_03898 ENOG4108N23 SpoOM-related protein S101395_03899 ENOG4105FF2 Type I DHQase S101395_03903 ENOG4105C22 threonyL-tRNA synthetase S101395_03911 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase S101395_03958 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) S101395_03960 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) S101395_03961 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_03962 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) S101395_03963 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) S101395_03982 ENOG4108IMY Transcriptional regulator S101395_04002 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101395_04020 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) S101395_04022 ENOG4105EE0 oxidoreductase S101395_04023 ENOG4105C8Q Methyl-accepting chemotaxis S101395_04024 ENOG4105C8Q Methyl-accepting chemotaxis S101395_04025 ENOG4105C8Q Methyl-accepting chemotaxis S101395_04026 ENOG4105C8Q Methyl-accepting chemotaxis S101395_04028 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme S101395_04030 ENOG4105C37 (CBS) domain S101395_04032 ENOG4107PBV potassium channel S101395_04033 ENOG4107PBV potassium channel S101395_04035 ENOG410900G Protein of unknown function (DUF421) S101395_04036 ENOG4107QYV phosphohexose isomerase S101395_04037 ENOG4107QW4 alcohol dehydrogenase S101395_04038 ENOG4105WG9 Conserved Protein S101395_04040 ENOG4105CHM Aminotransferase S101395_04041 ENOG4108ZB6 transcriptional regulator AsnC family S101395_04042 ENOG4108MUZ hydrolase S101395_04045 ENOG4105C87 Aminotransferase class I and II S101395_04047 ENOG4105Y38 Kinase-associated protein B S101395_04050 ENOG4105BZ4 penicillin-binding protein S101395_04051 ENOG4105KIR Thiol-disulfide oxidoreductase dcc S101395_04054 ENOG4108MRH transcriptional regulatory protein S101395_04055 ENOG4105DIH basic membrane S101395_04056 ENOG4108JQ9 ABC transporter S101395_04057 ENOG4105UIB (ABC) transporter S101395_04060 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase S101395_04061 ENOG4107ZTW SNARE associated Golgi S101395_04062 ENOG4105DJ4 phosphatidylserine decarboxylase S101395_04065 ENOG4105D65 subunit l S101395_04066 ENOG4105D65 subunit l S101395_04067 ENOG4105HC0 Na H antiporter S101395_04068 ENOG4108ZE9 Monovalent cation H antiporter subunit C S101395_04069 ENOG4108JPZ Monovalent cation H antiporter subunit D S101395_04070 ENOG4105SC1 monovalent cation H antiporter subunit E S101395_04072 ENOG4105KJM monovalent cation h antiporter subunit g S101395_04073 ENOG4105KA0 thioesterase Superfamily protein S101395_04075 ENOG4105BZU Histidine kinase S101395_04076 ENOG4105BZU Histidine kinase S101395_04081 ENOG4105D58 Diguanylate phosphodiesterase S101395_04082 ENOG4105DAP Nicotinate phosphoribosyltransferase S101395_04087 ENOG4105C02 permease S101395_04088 ENOG4108Z40 Transcriptional regulator S101395_04093 ENOG410904N short-chain dehydrogenase reductase S101395_04102 ENOG4105BZG amino acid carrier protein S101395_04103 ENOG4108K8K Transcriptional regulator S101395_04104 ENOG4105DCF alanine dehydrogenase S101395_04109 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) S101395_04111 ENOG41069ER domain protein S101395_04113 ENOG4105CEP NADH dehydrogenase S101395_04114 ENOG4105CAY ferredoxin--nadp reductase S101395_04117 ENOG4108YX9 iron--sulfur cluster insertion protein erpA S101395_04125 ENOG4105PY6 Phenolic acid decarboxylase S101395_04128 ENOG41083MR nifu domain-containing protein S101395_04129 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein S101395_04130 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) S101395_04131 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) S101395_04132 ENOG4105D6E homoserine dehydrogenase S101395_04133 ENOG4105C5I Dehydrogenase S101395_04135 ENOG4108W5N phosphatidylglycerophosphatase a S101395_04136 ENOG4105D4U had-superfamily hydrolase, subfamily iia S101395_04138 ENOG4105MMD transcriptional regulator S101395_04139 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) S101395_04140 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) S101395_04141 ENOG4105FAA peptidase M23 S101395_04143 ENOG4105C8J )-transporter S101395_04144 ENOG4108YTE sporulation protein YunB S101395_04145 ENOG4105KZD Domain of unknown function (DUF1805) S101395_04146 ENOG4107R8B 5'-nucleotidase S101395_04148 ENOG4105I3N Conserved Protein S101395_04149 ENOG4105IIP Membrane S101395_04150 ENOG4105W1N transcriptional regulator S101395_04151 ENOG4105CD3 dihydroorotase S101395_04152 ENOG4105CD3 dihydroorotase S101395_04153 ENOG4105C5R Aminotransferase S101395_04155 ENOG4105G9B Transcriptional regulator S101395_04159 ENOG4108I0Q anthranilate phosphoribosyltransferase S101395_04160 ENOG4108K8S endonuclease I S101395_04161 ENOG4108IJ9 (ABC) transporter S101395_04162 ENOG4105FDP GntR family transcriptional regulator S101395_04163 ENOG4108KPW sugar kinase S101395_04164 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S101395_04165 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S101395_04166 ENOG4105XN3 extracellular solute-binding protein family 1 S101395_04167 ENOG4105XN3 extracellular solute-binding protein family 1 S101395_04168 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine S101395_04169 ENOG4107VFR oxidoreductase S101395_04172 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) S101395_04175 ENOG4105CFC Transporter S101395_04176 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) S101395_04181 ENOG4105DIW FeS assembly protein SUFB S101395_04182 ENOG4108UNV SUF system FeS assembly protein, NifU family S101395_04183 ENOG4105C9B Cysteine desulfurase S101395_04184 ENOG4105JRK feS assembly protein SufD S101395_04185 ENOG4105C3K feS assembly ATPase SufC S101395_04186 ENOG4105PGM cation diffusion facilitator family transporter S101395_04188 ENOG4105D01 (LipO)protein S101395_04189 ENOG4108UMI ABC transporter, permease S101395_04190 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) S101395_04196 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) S101395_04197 ENOG41080E8 Transcriptional regulator, Spx MgsR family S101395_04198 ENOG4105C1G acyl-Coa dehydrogenase S101395_04199 ENOG4105CHU acetyl-coa acetyltransferase S101395_04206 ENOG4105E0A ABC, transporter S101395_04207 ENOG4108IHU transport system permease protein S101395_04208 ENOG4105DQ5 transport system permease protein S101395_04209 ENOG4108MES Periplasmic binding protein S101395_04212 ENOG4105DZ1 carboxypeptidase S101395_04213 ENOG4105E1F short-chain dehydrogenase reductase S101395_04214 ENOG4105HUF DNA protection during starvation protein S101395_04215 ENOG4105C0H protease S101395_04217 ENOG4105F3H Histidine kinase S101395_04218 ENOG41067SE Tetr family transcriptional regulator S101395_04219 ENOG4105C9Q fumarate hydratase class II S101395_04225 ENOG4105WH1 Two component transcriptional regulator luxr family S101395_04226 ENOG4105ENE Histidine kinase S101395_04229 ENOG41087YS Phage shock protein A S101395_04232 ENOG4108WBT adenosyltransferase S101395_04233 ENOG4105E0A ABC, transporter S101395_04234 ENOG4105EHG Permease protein S101395_04235 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) S101395_04236 ENOG4105EWI Short-chain dehydrogenase reductase Sdr S101395_04237 ENOG4108RPX mosc domain containing protein S101395_04238 ENOG4105DUM transcriptional regulator, lysR family S101395_04241 ENOG4105CTX dehydratase S101395_04242 ENOG4107QZW Altronate oxidoreductase S101395_04243 ENOG4107KJX Transcriptional regulator S101395_04244 ENOG4105CT4 transporter S101395_04245 ENOG4105D2H Uronic isomerase S101395_04247 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101395_04248 ENOG4105E0A ABC, transporter S101395_04249 ENOG4105EHG Permease protein S101395_04250 ENOG4105DQ5 transport system permease protein S101395_04251 ENOG4105D5Q Arginine ornithine antiporter S101395_04253 ENOG4107K5X Membrane-bound metal-dependent hydrolase S101395_04254 ENOG4107QZ2 Sulfatase S101395_04257 ENOG4105EVU fructokinase S101395_04258 ENOG4105EEQ Na H antiporter S101395_04259 ENOG4107EPV Aminotransferase class V S101395_04261 ENOG4105EEM helicase S101395_04262 ENOG4105EN6 Membrane S101395_04270 ENOG4107ZQN disulfide bond S101395_04271 ENOG4105C59 p-type ATPase S101395_04273 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component S101395_04274 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component S101395_04275 ENOG4105CJQ hydrolase, family 31 S101395_04277 ENOG4105DIK (ABC) transporter S101395_04278 ENOG4105CC5 ABC transporter S101395_04279 ENOG4105DSE periplasmic solute binding protein S101395_04280 ENOG4105DSE periplasmic solute binding protein S101395_04281 ENOG4105HX0 Transcriptional regulator S101395_04282 ENOG4105DE4 1-phosphofructokinase S101395_04283 ENOG4105DM4 PTS System S101395_04284 ENOG4105DM4 PTS System S101395_04286 ENOG4105C59 p-type ATPase S101395_04287 ENOG410681U heavy metal transport detoxification protein S101395_04288 ENOG4105VPX protein, conserved in bacteria S101395_04289 ENOG4108Z0Z intracellular protease Pfpi family S101395_04290 ENOG4105E98 transcriptional regulator DeoR family S101395_04291 ENOG4105DET Rhamnulokinase S101395_04293 ENOG4105F27 Major Facilitator S101395_04294 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) S101395_04298 ENOG4105D9R oxidoreductase S101395_04300 ENOG4105C72 UPF0176 protein S101395_04302 ENOG4106DF4 Sigma-70, region 4 S101395_04304 ENOG4105F0F Oxalate decarboxylase S101395_04312 ENOG4107EV6 Inherit from COG: YD repeat protein S101395_04321 ENOG41068G1 S101395_04323 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj S101395_04325 ENOG4108FKH Transglycosylase SLT domain S101395_04335 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) S101395_04338 ENOG4105CAR Terminase, large subunit S101395_04362 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) S101395_04363 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) S101395_04364 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) S101395_04365 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) S101395_04366 ENOG4108TYN CAAX amino terminal protease family protein S101395_04368 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S101395_04369 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S101395_04370 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) S101395_04372 ENOG4105C5H ABC transporter S101395_04373 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) S101395_04374 ENOG410801F ribosomal-protein-alanine acetyltransferase S101395_04375 ENOG41072GX Peptidase M22 Glycoprotease S101395_04376 ENOG4105K8N protein family UPF0079, ATPase S101395_04377 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) S101395_04385 ENOG4107QNK )-transporter S101395_04386 ENOG4108Z6X (sortase) family S101395_04390 ENOG4105C2C drug resistance transporter, Bcr CflA S101395_04392 ENOG4105EXC Acyl-transferase S101395_04393 ENOG4108P49 AntiSigma factor S101395_04394 ENOG4105JVQ RNA Polymerase S101395_04395 ENOG4105X5K response regulator receiver protein S101395_04396 ENOG4108VQT Alpha beta hydrolase fold protein S101395_04397 ENOG4105CHR reductase S101395_04398 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) S101395_04403 ENOG4105C85 amino acid S101395_04404 ENOG4105FQP Beta-lactamase S101395_04405 ENOG4108TVJ Nitroreductase S101395_04406 ENOG4105FS7 Transcriptional regulator S101395_04408 ENOG4108VP3 Lysine exporter protein (LysE YggA) S101395_04409 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase S101395_04411 ENOG4108JGH Tetr family transcriptional regulator S101395_04412 ENOG4105EQ0 Major Facilitator superfamily S101395_04413 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein S101395_04414 ENOG4105KVH Transcriptional regulator S101395_04415 ENOG41090E6 transcriptional regulator MERR family S101395_04418 ENOG4105KME endoribonuclease L-psp S101395_04419 ENOG4105C6T cysteine synthase S101395_04422 ENOG4105KVH Transcriptional regulator S101395_04426 ENOG4105D3P Mannan endo-1,4-beta-mannosidase S101395_04427 ENOG4105CZ9 Domain of unknown function (DU1801) S101395_04428 ENOG4105KBH arsR family transcriptional regulator S101395_04429 ENOG4105DXI Major Facilitator superfamily S101395_04430 ENOG4107U9B transcriptional regulator S101395_04431 ENOG4105VEQ Cold shock protein S101395_04432 ENOG4105ECK Fatty Acid Desaturase S101395_04433 ENOG4107T94 Endo-14-beta-xylanase S101395_04446 ENOG4105EYF MMPL domain protein S101395_04447 ENOG4105ST3 Transcriptional regulator S101395_04449 ENOG41064BQ Phosphatase S101395_04453 ENOG4107SGM protein serine threonine phosphatase S101395_04454 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase S101395_04455 ENOG4105FUA antagonist S101395_04456 ENOG4107MMM Anti-sigma-factor antagonist S101395_04457 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) S101395_04459 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) S101395_04460 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein S101395_04462 ENOG4105CKV Membrane S101395_04463 ENOG410905X membrane-flanked domain protein S101395_04464 ENOG4105C1J atp-dependent rna helicase S101395_04466 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) S101395_04467 ENOG4105CPF Cell wall formation (By similarity) S101395_04468 ENOG4105SZ6 Thioredoxin S101395_04471 ENOG4105FDT acyl-CoA dehydrogenase S101395_04474 ENOG4105CJ1 ABC, transporter S101395_04475 ENOG4105CK2 sodium dicarboxylate symporter S101395_04476 ENOG4106F5Q Membrane S101395_04477 ENOG4106F5Q Membrane S101395_04481 ENOG4105EU9 S101395_04482 ENOG41087PP glycosyltransferase MGT family S101395_04483 ENOG4108IJ0 Aspartate ammonia-lyase S101395_04484 ENOG4107BMA Transglycosylase associated protein S101395_04485 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) S101395_04488 ENOG4105CHR reductase S101395_04491 ENOG4105C0X amino acid S101395_04493 ENOG41089UC methyltransferase, type 11 S101395_04495 ENOG4105C9U ATP-dependent DNA helicase RecQ S101395_04498 ENOG4105VCH membrane S101395_04499 ENOG4108RCF TRANSCRIPTIONal S101395_04501 ENOG410606W general stress protein S101395_04503 ENOG4105CYX Short-chain dehydrogenase reductase Sdr S101395_04504 ENOG4105ETD TRANSCRIPTIONal S101395_04505 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase S101395_04508 ENOG4105XJB lipolytic protein G-D-S-L family S101395_04509 ENOG4107258 Transcriptional regulator S101395_04511 ENOG4105P4J Allophanate hydrolase, subunit 1 S101395_04512 ENOG4105CFM UPF0317 protein S101395_04513 ENOG4105C5A transporter S101395_04514 ENOG4105E7W lamb ycsf family protein S101395_04527 ENOG4105C8P )-transporter S101395_04528 ENOG4105DRR Transcriptional regulator, GntR family S101395_04530 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) S101395_04532 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit S101395_04533 ENOG4108IFG nitrite reductase, (NAD(P)H) S101395_04534 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) S101395_04538 ENOG4108ZYE Transcriptional regulator S101395_04539 ENOG4108T5E Copper resistance protein S101395_04540 ENOG4105KTB nuclear export factor GLE1 S101395_04541 ENOG4108RNG Permease of the drug metabolite transporter S101395_04542 ENOG4105C26 Dehydrogenase S101395_04543 ENOG4107QTZ amino acid S101395_04544 ENOG4108JPW Aminotransferase S101395_04545 ENOG4108JPW Aminotransferase S101395_04548 ENOG4105YVS arsR family transcriptional regulator S101395_04549 ENOG41067V3 Antibiotic biosynthesis monooxygenase S101395_04550 ENOG4108DBC nitroreductase S101395_04552 ENOG4105R8C Transcriptional regulator S101395_04556 ENOG4108IPW abc transporter atp-binding protein S101395_04557 ENOG4105CM4 permease protein S101395_04558 ENOG4105CM4 permease protein S101395_04559 ENOG4105DHS permease protein S101395_04560 ENOG4105CFH Aspartokinase S101395_04561 ENOG4105CFH Aspartokinase S101395_04562 ENOG4105EC8 Methyl-accepting chemotaxis S101395_04563 ENOG4105BZU Histidine kinase S101395_04564 ENOG4105BZU Histidine kinase S101395_04565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101395_04566 ENOG4107WD8 ABC transporter, permease S101395_04570 ENOG4107TXC Transcriptional regulator S101395_04574 ENOG4105E1K spore germination protein S101395_04577 ENOG4105DUX Transporter S101395_04578 ENOG4107T32 3-phytase (EC 3.1.3.8) S101395_04579 ENOG4105C4C beta-galactosidase S101395_04580 ENOG410645S MarR family Transcriptional regulator S101395_04581 ENOG410645S MarR family Transcriptional regulator S101395_04582 ENOG4105DCM major facilitator superfamily S101395_04583 ENOG4108HWW ABC transporter S101395_04585 ENOG4105DFW ABC transporter S101395_04586 ENOG4105EQD regulatoR S101395_04587 ENOG4105C2F Histidine kinase S101395_04588 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator S101395_04591 ENOG4107EV6 Inherit from COG: YD repeat protein S101395_04596 ENOG41069ZX S101395_04597 ENOG41069ZX S101395_04598 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) S101395_04599 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase S101395_04600 ENOG4106P55 Transcriptional regulator S101395_04601 ENOG4106P55 Transcriptional regulator S101395_04603 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 S101395_04605 ENOG4108U05 Transcriptional regulator S101395_04607 ENOG41066UZ arginase EC 3.5.3.1 S101395_04608 ENOG4108IQI permease S101395_04609 ENOG4105C8Y Acetylornithine aminotransferase S101395_04610 ENOG4108JUB Transcriptional regulator S101395_04612 ENOG4105DRP amino acid AbC transporter S101395_04613 ENOG4105CDA abc transporter atp-binding protein S101395_04623 ENOG41086D8 Transcriptional regulator S101395_04624 ENOG4108SA1 esterase S101395_04625 ENOG4105W8Z 4'-phosphopantetheinyl transferase S101395_04627 ENOG4105SX7 Transporter S101395_04631 ENOG4105CEY Amp-dependent synthetase and ligase S101395_04632 ENOG4105D94 Major Facilitator Superfamily S101395_04635 ENOG4105F38 ABC transporter, permease S101395_04637 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) S101395_04644 ENOG4105CS2 ec 3.2.1.21 S101395_04646 ENOG4105E0A ABC, transporter S101395_04647 ENOG4108U1V ABC transporter, permease S101395_04648 ENOG4105DQ5 transport system permease protein S101395_04649 ENOG4108HUF Transporter S101395_04651 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein S101395_04652 ENOG4105E5Q amino acid AbC transporter S101395_04657 ENOG4105I82 acetyl xylan esterase S101395_04658 ENOG4107XC4 flavin reductase domain protein, FMN-binding S101395_04659 ENOG4108PJD permease S101395_04661 ENOG4107YHD transcriptional regulator S101395_04662 ENOG4105CK7 Sodium proline symporter S101395_04663 ENOG4105CK7 Sodium proline symporter S101395_04664 ENOG4105C26 Dehydrogenase S101395_04666 ENOG410756H nucleotidyltransferase S101395_04667 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) S101395_04678 ENOG4107SQ8 Glycine betaine S101395_04679 ENOG4108IJ7 Glycine betaine S101395_04681 ENOG4108TTB tellurium resistance protein S101395_04687 ENOG4107TS3 membrane protein, TerC S101395_04688 ENOG4106FN3 tellurium resistance protein S101395_04689 ENOG4106FN3 tellurium resistance protein S101395_04690 ENOG4108N0M stress protein S101395_04693 ENOG4108RZE Tetr family transcriptional regulator S101395_04694 ENOG4105CIG ABC transporter S101395_04696 ENOG4105Z8B NlpC/P60 family S101395_04697 ENOG4105DEN Luciferase family S101395_04699 ENOG4105KHC sulfurtransferase S101395_04702 ENOG4105H9W Short-chain dehydrogenase reductase Sdr S101395_04703 ENOG4108CHM Preferentially cleaves peptide bonds on the carboxyl- terminal side of aspartate and glutamate. Along with other extracellular proteases it is involved in colonization and infection of human tissues. Required for proteolytic maturation of thiol protease SspB and inactivation of SspC, an inhibitor of SspB. It is the most important protease for degradation of fibronectin-binding protein (FnBP) and surface protein A, which are involved in adherence to host cells. May also protect bacteria against host defense mechanism by cleaving the immunoglobulin classes IgG, IgA and IgM. May be involved in the stability of secreted lipases S101395_04704 ENOG4105CQB FAD linked oxidase domain protein S101395_04705 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) S101395_04707 ENOG4107BMA Transglycosylase associated protein S101395_04708 ENOG4105DPN Oligoendopeptidase f S101395_04710 ENOG4108W0I acetyltransferase S101395_04711 ENOG4107RB3 L-asparaginase S101395_04719 ENOG4105MDS 4-oxalocrotonate tautomerase S101395_04720 ENOG4107RSM transcriptional regulator S101395_04721 ENOG41060AI SEC-C motif S101395_04723 ENOG4106UX7 integral membrane protein S101395_04725 ENOG4107TXC Transcriptional regulator S101395_04730 ENOG41067TZ transcriptional regulator, MarR family S101395_04733 ENOG4106K80 S101395_04734 ENOG4108R1P S101395_04739 ENOG4105DPZ Two component transcriptional regulator (Winged helix family S101395_04741 ENOG4106FGC S101395_04743 ENOG4105CTX dehydratase S101395_04744 ENOG41073TP transcriptional regulator S101395_04745 ENOG4105EQX glucarate dehydratase S101395_04746 ENOG4105DJB Major Facilitator Superfamily S101395_04747 ENOG4105C26 Dehydrogenase S101395_04748 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase S101395_04749 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) S101395_04750 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) S101395_04751 ENOG4105DGI Alkaline phosphatase S101395_04752 ENOG4105KNA -acetyltransferase S101395_04755 ENOG4105CSV Glutaminase S101395_04760 ENOG4105CUB amino acid S101395_04761 ENOG4107TXC Transcriptional regulator S101395_04764 ENOG410901P UPF0249 protein S101395_04765 ENOG4108X79 transcriptional regulator S101395_04766 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S101395_04767 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane S101395_04769 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid S101395_04771 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) S101395_04772 ENOG4107SCQ Iron-containing alcohol dehydrogenase S101395_04776 ENOG4106AXJ AraC family transcriptional regulator S101395_04777 ENOG410631K Membrane S101395_04782 ENOG4107I77 yiaA/B two helix domain S101395_04786 ENOG4105DRR Transcriptional regulator, GntR family S101395_04787 ENOG4108TVJ Nitroreductase S101395_04795 ENOG4108WC5 Alpha Beta Hydrolase Fold protein S101395_04797 ENOG4108UZ3 Transporter S101395_04798 ENOG4108MCI Transcriptional regulator, ARAC family S101395_04800 ENOG4105FTQ Dna gyrase S101395_04801 ENOG4105C7Z Conserved Protein S101395_04802 ENOG4105ED2 Beta-lactamase S101395_04804 ENOG4105FTQ Dna gyrase S101395_04805 ENOG4105C7Z Conserved Protein S101395_04808 ENOG4105C7Z Conserved Protein S101395_04809 ENOG4105C7Z Conserved Protein S101395_04813 ENOG4106DDH Sporulation-specific SASP protein S101395_04820 ENOG41075D4 Aminoglycoside 6-adenylyltransferase S101395_04825 ENOG4107ZXU DSBA oxidoreductase S101395_04827 ENOG4105CJ1 ABC, transporter S101395_04830 ENOG4105BZ1 (ABC) transporter S101395_04835 ENOG4105DA5 (ABC) transporter S101395_04841 ENOG4105D9U N-acetyltransferase S101395_04842 ENOG4108XG4 DNA-binding transcriptional regulator S101395_04843 ENOG4108RWP Major Facilitator Superfamily protein S101395_04844 ENOG4105WAB arsR family transcriptional regulator S101395_04846 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family S101395_04851 ENOG4105CS2 ec 3.2.1.21 S101395_04852 ENOG4105C5Y PTS System S101395_04854 ENOG4105C5Y PTS System S101395_04855 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) S101395_04856 ENOG4108IUS Transketolase S101395_04857 ENOG4108HHA Transketolase S101395_04859 ENOG4105ETE Transcriptional regulator (LacI family S101395_04860 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) S101395_04861 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) S101395_04862 ENOG4107U5W ybbr family S101395_04863 ENOG4105C8B TIGR00159 family S101395_04865 ENOG4105EMN RNA polymerase sigma factor S101395_04872 ENOG4105EWC Purine nucleoside phosphorylase S101395_04873 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S101395_04877 ENOG4105D17 glycoside hydrolase, family 3 domain protein S101395_04878 ENOG4105EHZ conserved protein UCP016719 S101395_04881 ENOG4108A04 Beta-lactamase S101395_04886 ENOG4107EV6 Inherit from COG: YD repeat protein S101395_04892 ENOG4105EDW glycosyl transferase, family 39 S101395_04893 ENOG4105CKK Glycosyl transferase, family 2 S101395_04894 ENOG4105CMR udp-glucose 4-epimerase S101395_04896 ENOG4105CH6 catalase S101395_04897 ENOG4105D4T Citrate transporter S101395_04898 ENOG4105CS2 ec 3.2.1.21 S101395_04899 ENOG4105C5Y PTS System S101395_04900 ENOG4105CID antiterminator S101395_04901 ENOG4108W7F transporter, permease S101395_04902 ENOG4108JJB ABC transporter S101395_04903 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein S101395_04904 ENOG4105ETU transcriptional activator (TenA S101395_04907 ENOG4105D2M Aldolase S101395_04908 ENOG4106VEM tagatose-6-phosphate kinase S101395_04909 ENOG4108YZG isomerase S101395_04910 ENOG4105RSI Galactose-6-phosphate isomerase subunit LacA S101395_04911 ENOG4105E98 transcriptional regulator DeoR family S101395_04914 ENOG4105DT3 PTS system, galactitol-specific IIc component S101395_04915 ENOG410667J hydrolase S101395_04917 ENOG4107QP3 malate synthase g S101395_04919 ENOG4105EDW glycosyl transferase, family 39 S101395_04921 ENOG4105C19 ABC transporter S101395_04922 ENOG4105EWM Histidine kinase S101395_04924 ENOG4105CS2 ec 3.2.1.21 S101395_04925 ENOG4105C5Y PTS System S101395_04928 ENOG4107QHE Choloylglycine hydrolase S101395_04930 ENOG4106Z5D Glycoside Hydrolase Family 43 S101395_04931 ENOG4105C1J atp-dependent rna helicase S101395_04937 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) S101395_04938 ENOG4105D9N nucleoside S101395_04939 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) S101395_04940 ENOG4107RHR regulatoR S101395_04947 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) S101395_04948 ENOG4107R8N Glycosyl transferase, family 2 S101395_04950 ENOG4105JKW Valine--pyruvate aminotransferase S101395_04955 ENOG4105D2N Aldolase S101395_04956 ENOG4107TRN Xylose isomerase domain protein TIM barrel S101395_04957 ENOG4105F0H myo-inositol catabolism protein S101395_04958 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101395_04959 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) S101395_04961 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) S101395_04962 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) S101395_04963 ENOG4105D7K pfkb domain protein S101395_04964 ENOG4105DH8 myo-inositol catabolism S101395_04965 ENOG4105C26 Dehydrogenase S101395_04967 ENOG4105CPC Aldo Keto reductase S101395_04968 ENOG4107VXM glycerophosphoryl diester phosphodiesterase S101395_04969 ENOG4105CXY transporter S101395_04970 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) S101395_04971 ENOG4105C5H ABC transporter S101395_04972 ENOG410667J hydrolase S101395_04974 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) S101395_04976 ENOG4108V5C ABC transporter S101395_04981 ENOG4105H93 Acyltransferase family S101395_04987 ENOG4105EC8 Methyl-accepting chemotaxis S101395_04988 ENOG4105BZG amino acid carrier protein S101395_04989 ENOG4105DCF alanine dehydrogenase S101395_04992 ENOG4105EG2 ABC transporter, permease S101395_04994 ENOG4107FKK extracellular solute-binding protein family 1 S101395_04996 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) S101395_04997 ENOG4105CMR udp-glucose 4-epimerase S101395_04998 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase S101395_04999 ENOG4105E2R ROK family S101395_05001 ENOG41082J7 Rhodanese domain protein S101395_05004 ENOG4105CMG Carbohydrate kinase S101395_05005 ENOG4105C6Z Gluconate S101395_05006 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) S101395_05007 ENOG4108EKI Dehydrogenase S101395_05008 ENOG4105D3R alkyl hydroperoxide reductase S101395_05009 ENOG4108JU3 Alkyl hydroperoxide reductase S101395_05011 ENOG4105DQ5 transport system permease protein S101395_05012 ENOG4105EHG Permease protein S101395_05015 ENOG4108M15 ABC transporter S101395_05016 ENOG4105KCT ABC transporter S101395_05017 ENOG4105BZU Histidine kinase S101395_05025 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) S101395_05028 ENOG4105WQG acetyltransferase S101395_05031 ENOG4105C0H protease S101395_05032 ENOG4105Q2H domain protein S101395_05035 ENOG4105BZU Histidine kinase S101395_05036 ENOG4105CK6 Two component transcriptional regulator (Winged helix family S101395_05041 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis S101395_05043 ENOG4105CDU Replicative dna helicase S101395_05047 ENOG4105DJ2 Major Facilitator Superfamily S101395_05048 ENOG4105CE4 GlcNAc 6-P deacetylase S101395_05049 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) S101395_05050 ENOG4105FDP GntR family transcriptional regulator S101395_05051 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate S101395_05053 ENOG4105K9Q Binds to the 23S rRNA (By similarity) S101395_05054 ENOG4105BZR domain protein S101395_05055 ENOG4108XMW Membrane S101395_05058 ENOG4105CHH sulfate transporter S101395_05060 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) S101395_05061 ENOG4108UUM single-stranded DNA-binding protein S101395_05062 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) S101395_05063 ENOG4105C3G gtp-binding protein S101395_05064 ENOG4105VDK protein, conserved in bacteria S101395_05066 ENOG4108ZDA Sporulation protein YyaC S101395_05067 ENOG4105FA0 parb-like partition protein S101395_05068 ENOG4107QJE Chromosome Partitioning Protein S101395_05069 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) S101395_05071 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) S101395_05073 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) S101395_05074 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) S101395_05077 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)